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Home › Research › What the research found › Every row

Every row of the evidence table

One row per finding: what was tested, which way the result went, and how the study was built. The answer by area, and where the studies disagree, are on the main page.

Every row

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Area All 382 Care, carers and services 140 Medicines 85 Genes (not modifiable) 35 All modifiable factors together 27 Diet and supplements 23 Exercise and activity 21 Sleep, mood and social life 19 Hearing and vision 8 Alcohol, tobacco and cannabis 6 Infection and vaccination 5 Heart and metabolic health 4 Injury, delirium and falls 4 Environment 3 Cognitive activity 2
Question Both Prevention 190 Treatment 192
Direction Any Benefit 144 Harm 105 No effect 38 Mixed 37 No direction reported 58
Design Any meta-analysis 57 randomised trial 44 phase 3 trial 15 systematic review 9 phase 2 trial 10 cohort study 136 phase 1 trial 2 cross-sectional study 31 case-control study 14 modelling study 20 regulatory decision 7 company announcement 1 coverage determination 1 None 35
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Showing 1 of 382 rows for Severe (hospital-treated) infection. One row per study per exposure: a study that tested two different things appears twice, once for each.

Scroll the table sideways to see every column.

Research and outcomes, 1 row. Every row links to its source.
Exposure Question Direction Outcome measured Design People Effect size, as the source reported it Source
Severe (hospital-treated) infection Infection and vaccination Prevention Harm
why

Direction is for a hospital-treated infection: the raised dementia hazard (1.54) was barely attenuated by adjustment for frailty (1.49) and persisted among non-frail participants (1.34), so pre-existing frailty and comorbidity did not explain it.

 Incident dementia after a 5-year exposure window and 2-year washout, adjusted for frailty and comorbidity cohort study 449,223 Adjustment for frailty resulted in no statistically significant attenuation of the infection and dementia association (adjusted hazard ratio [HR] 1·54 [95% CI 1·43-1·67] for presence vs absence of severe infections before adjustment for frailty and 1·49 [1·37-1·61] after adjustment). The association was also evident within a subgroup of non-frail participants (1·34 [1·18-1·53]) The lancet. Healthy longevity 2026
✓ Peer-reviewed PMID 41969011

How this table was built, and where it is weak →