% alzhub.org topic: repurposing
% Source: https://alzhub.org/topic/repurposing
% 234 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{ugur2026-bb2a526b,
  author  = {Ugur, S. and Onal Suzek, T.},
  title   = {{Integrated Transcriptomic and Structural Prioritization of Sulforaphane Targets in Neurodegeneration: A Multi-Dataset In Silico Study}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.20.760417},
  url     = {https://doi.org/10.64898/2026.10.20.760417}
}

@article{iftikhar2026-5f7606f8,
  author  = {Iftikhar, H. and Ejaz, M. M. and Al-Namshah, K. S. and Khan, S. and Ashraf, S. and Meer, N. and Riaz, M. and Saleem, M.},
  title   = {{Natural Sesquiterpenoids from Laggera pterodonta as bioactive Acetylcholinesterase Inhibitors: Insights from DFT, Molecular Docking, and ADMET Profiling}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11218173/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11218173/v1}
}

@article{kaur2026-c1b494a3,
  author  = {Kaur, B. and Abdo, A. N. and Cho, S. and Gabr, M. T.},
  title   = {{DNA-Encoded Library-Guided Discovery of a First-in-Class Molecular Glue of the NOS1AP-SCRIB Complex in Alzheimer’s Disease Patient-Derived Neurons}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.12.758423},
  url     = {https://doi.org/10.64898/2026.10.12.758423}
}

@article{nago2026-f876eb5b,
  author  = {Nago, B. and Qu, C.},
  title   = {{Simulating the Effects of Gamma Oscillation Treatment on Selective Neurotransmitters Using The Virtual Brain and Complex Pathway Simulator}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11199141/v2},
  url     = {https://doi.org/10.21203/rs.3.rs-11199141/v2}
}

@article{dasgupta2026-cfdd9ac7,
  author  = {Dasgupta, M. and Konar, A. and Nagar, A.},
  title   = {{Magnetic Field–Enhanced Docosahexaenoic Acid Delivery for Acetylcholine Restoration in Alzheimer’s Disease: an In Silico Study}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.755051},
  url     = {https://doi.org/10.64898/2026.09.28.755051}
}

@article{etukudo2026-c4612b37,
  author  = {Etukudo, E. M. and Usman, I. M. and Oviosun, A. and Ojiakor, V. O. and Owembabazi, E. and Aja, P. M. and Anyanwu, E.},
  title   = {{Multi-Target Neuroprotection by Syzygium aromaticum Ethyl Acetate Fraction Against Mercuric Chloride-Induced Hippocampal Toxicity: Insights from Network Pharmacology, Molecular Docking, and In Vivo Evaluation}},
  journal = {F1000Res},
  year    = {2026},
  doi     = {10.12688/f1000research.186494.1},
  url     = {https://doi.org/10.12688/f1000research.186494.1}
}

@article{ejaz2026-f06e02fb,
  author  = {Ejaz, M. M. and Iftikhar, H. and Al-Namshah, K. and Khan, S. and Ashraf, S. and Meer, N. and Riaz, M. and Saleem, M. and others},
  title   = {{Substituent Effects on Electronic Properties and Acetylcholinesterase Inhibitory Potential of Donepezil Analogues: A DFT, Molecular Docking, and ADMET Study with Dynamics Validation of the Lead Candidate}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11082767/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11082767/v1}
}

@article{dange2026-86ec91fb,
  author  = {Dange¹, R. T. and Jadhav², S. B. and RAj, rupali},
  title   = {{Docking-Guided Design and Biological Evaluation of a Lead Convolvine-Based Acetylcholinesterase Inhibitor for Alzheimer's Disease}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10890265/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10890265/v1}
}

@article{patil2026-039d6010,
  author  = {Patil, S. P. and Kuehn, B. and Schlosser, R. and Samohod, J.},
  title   = {{Discovery of Bavachin as a Dual Trk-A/Trk-B Agonist via Integrated Computational Screening and Experimental Validation}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.10.750759},
  url     = {https://doi.org/10.64898/2026.09.10.750759}
}

@article{holtz2026-d33b0eda,
  author  = {Holtz, M. and de Haan, S. and Castellví Domingo, C. and Madsen, N. G. and Salazar, M. D. F. and Hansson, F. G. and van Aalst, A. C. A. and Arnesen, J. A. and others},
  title   = {{Biocatalytic Production of Galantamine in Yeast through Cytochrome P450 Optimization}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.09.750345},
  url     = {https://doi.org/10.64898/2026.09.09.750345}
}

@article{ban2026-0ffeafec,
  author  = {Ban, K. and Kajiwara, S. and Hashizume, T. and Ninomiya, M. and Koketsu, M.},
  title   = {{Structural optimization of coumarin-pyridine hybrid derivative salts as potent acetylcholinesterase inhibitors}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10583076/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10583076/v1}
}

@article{baral2026-e2e1ba0c,
  author  = {Baral, D. S. and Verma, R.},
  title   = {{Exploring the Molecular and Biochemical Mechanisms of Aromasin in Modulating COX-2/iNOS for Alzheimer’s Disease-Associated Synaptic Dysfunction: An In Silico Drug Repurposing Study}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10701602/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10701602/v1}
}

@article{rautela2026-3e3bf661,
  author  = {Rautela, R. and Gupta, S. M. and Gaurav, A.},
  title   = {{Discovery of Natural Cholinesterase Inhibitors via Integrated Computational Studies using Labdane-Related Diterpenoids-based Pharmacophore Model and in-vitro studies}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10417596/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10417596/v1}
}

@article{rathi2026-5bb621f8,
  author  = {Rathi, R.},
  title   = {{Computational Screening of 1,348 FDA-Approved Drugs as Potential BACE1 Inhibitors for Alzheimer's Disease Drug Repurposing}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10484841/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10484841/v1}
}

@article{rathi2026-2e030f13,
  author  = {Rathi, R.},
  title   = {{Computational Screening of FDA-Approved Drugs as Potential BACE1 Inhibitors for Alzheimer's Disease Drug Repurposing}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10465925/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10465925/v1}
}

@article{shimbara2026-f6000fdf,
  author  = {Shimbara, K.},
  title   = {{Network Pharmacology and Molecular Docking Uncover Novel Candidate Compound-Target Actions of Yokukansan (Yi-Gan San) in the Behavioral and Psychological Symptoms of Dementia}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202607.1493.v1},
  url     = {https://doi.org/10.20944/preprints202607.1493.v1}
}

@article{ivanova2025-41096712,
  author  = {Ivanova, Anna V and Kutuzova, Alexandra D and Kuzmichev, Ilia A and Abakumov, Maxim A},
  title   = {{Alzheimer's Disease: From Molecular Mechanisms to Promising Therapeutic Strategies}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26199444},
  pmid    = {41096712},
  url     = {https://doi.org/10.3390/ijms26199444}
}

@article{ota2025-41047647,
  author  = {Ota, Miho and Arai, Tetsuaki},
  title   = {{[Pharmacological Interventions in Dementia]}},
  journal = {No shinkei geka. Neurological surgery},
  year    = {2025},
  doi     = {10.11477/mf.030126030530050943},
  pmid    = {41047647},
  url     = {https://doi.org/10.11477/mf.030126030530050943}
}

@article{office2025-40429612,
  author  = {Office, Internation Journal Of Molecular Sciences Editorial},
  title   = {{Expression of Concern: Paladugu et al. Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer's Disease. Int. J. Mol. Sci. 2021, 22, 860}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26104467},
  pmid    = {40429612},
  url     = {https://doi.org/10.3390/ijms26104467}
}

@article{cummings2025-39971900,
  author  = {Cummings, Jeffrey L and Zhou, Yadi and Van Stone, Alexandra and Cammann, Davis and Tonegawa-Kuji, Reina and Fonseca, Jorge and Cheng, Feixiong},
  title   = {{Drug repurposing for Alzheimer's disease and other neurodegenerative disorders}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-56690-4},
  pmid    = {39971900},
  url     = {https://doi.org/10.1038/s41467-025-56690-4}
}

@article{barkerhaliski2025-39784685,
  author  = {Barker-Haliski, Melissa},
  title   = {{Seizing the opportunity to therapeutically address neuronal hyperexcitability in Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877241305740},
  pmid    = {39784685},
  url     = {https://doi.org/10.1177/13872877241305740}
}

@article{ma2025-39714451,
  author  = {Ma, Mengmeng and Wang, Jing and Guo, Kaiming and Zhong, Wenbin and Cheng, Yu and Lin, Li and Zhao, Yanli},
  title   = {{A Self-Reinforced "Microglia Energy Modulator" for Synergistic Amyloid-β Clearance in Alzheimer's Disease Model}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2025},
  doi     = {10.1002/anie.202420547},
  pmid    = {39714451},
  url     = {https://doi.org/10.1002/anie.202420547}
}

@article{frost2024-39766362,
  author  = {Frost, Emma D and Shi, Swanny X and Byroju, Vishnu V and Rissardo, Jamir Pitton and Donlon, Jack and Vigilante, Nicholas and Murray, Briana P and Walker, Ian M and others},
  title   = {{Galantamine-Memantine Combination in the Treatment of Parkinson's Disease Dementia}},
  journal = {Brain sciences},
  year    = {2024},
  doi     = {10.3390/brainsci14121163},
  pmid    = {39766362},
  url     = {https://doi.org/10.3390/brainsci14121163}
}

@article{masters2025-39668075,
  author  = {Masters, Colin L},
  title   = {{Neuropathology meets chemical and genetic pathology head-on: a personal perspective}},
  journal = {Pathology},
  year    = {2025},
  doi     = {10.1016/j.pathol.2024.11.001},
  pmid    = {39668075},
  url     = {https://doi.org/10.1016/j.pathol.2024.11.001}
}

@article{conceicao2024-39525305,
  author  = {Conceição, Mariana and Di Filippo, Leonardo Delello and Duarte, Jonatas Lobato and Beserra, Fernando Pereira and Gremião, Maria Palmira Daflon and Chorilli, Marlus},
  title   = {{Repurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective}},
  journal = {Brain, behavior, \& immunity - health},
  year    = {2024},
  doi     = {10.1016/j.bbih.2024.100894},
  pmid    = {39525305},
  url     = {https://doi.org/10.1016/j.bbih.2024.100894}
}

@article{zhang2024-39405916,
  author  = {Zhang, Yinbing and Tang, Cheng and He, Yao and Zhang, Yingqian and Li, Qinxi and Zhang, Ting and Zhao, Bangcheng and Tong, Aiping and others},
  title   = {{Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and human brain organoid models}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2024},
  doi     = {10.1016/j.biopha.2024.117540},
  pmid    = {39405916},
  url     = {https://doi.org/10.1016/j.biopha.2024.117540}
}

@article{kumar2024-38270120,
  author  = {Kumar, Ashish and Kim, Fred and Song, Dong-Keun and Choung, Jai Jun},
  title   = {{Polypharmacological Potential of Phosphodiesterase 5 Inhibitors for the Treatment of Neurocognitive Disorders}},
  journal = {Aging and disease},
  year    = {2024},
  doi     = {10.14336/ad.2023.1129},
  pmid    = {38270120},
  url     = {https://doi.org/10.14336/ad.2023.1129}
}

@article{zhang2024-39174535,
  author  = {Zhang, J. and Zhang, Y. and Wang, J. and Xia, Y. and Chen, L.},
  title   = {{Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies}},
  journal = {Signal transduction and targeted therapy},
  year    = {2024},
  doi     = {10.1038/s41392-024-01911-3},
  pmid    = {39174535},
  url     = {https://doi.org/10.1038/s41392-024-01911-3}
}

@article{alhorani2024-40828109,
  author  = {Al-Horani, Rami A},
  title   = {{Sulfopropanoic acid derivatives for treating neurodegenerative disorders: a patent spotlight}},
  journal = {Pharmaceutical patent analyst},
  year    = {2024},
  doi     = {10.1080/20468954.2024.2363657},
  pmid    = {40828109},
  url     = {https://doi.org/10.1080/20468954.2024.2363657}
}

@article{shukla2024-38942541,
  author  = {Shukla, Halak and John, Diana and Banerjee, Shuvomoy and Tiwari, Anand Krishna},
  title   = {{Drug repurposing for neurodegenerative diseases}},
  journal = {Progress in molecular biology and translational science},
  year    = {2024},
  doi     = {10.1016/bs.pmbts.2024.03.035},
  pmid    = {38942541},
  url     = {https://doi.org/10.1016/bs.pmbts.2024.03.035}
}

@article{weber2024-38763001,
  author  = {Weber, Patrick and Bojarová, Pavla and Brouzdová, Jitka and Křen, Vladimír and Kulik, Natalia and Stütz, Arnold E and Thonhofer, Martin and Wrodnigg, Tanja M},
  title   = {{Diaminocyclopentane - l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase}},
  journal = {Bioorganic chemistry},
  year    = {2024},
  doi     = {10.1016/j.bioorg.2024.107452},
  pmid    = {38763001},
  url     = {https://doi.org/10.1016/j.bioorg.2024.107452}
}

@article{ramos2024-38674150,
  author  = {Ramos, Raquel and Vale, Nuno},
  title   = {{Dual Drug Repurposing: The Example of Saracatinib}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25084565},
  pmid    = {38674150},
  url     = {https://doi.org/10.3390/ijms25084565}
}

@article{singh2024-38286338,
  author  = {Singh, B. and Day, C. M. and Abdella, S. and Garg, S.},
  title   = {{Alzheimer's disease current therapies, novel drug delivery systems and future directions for better disease management}},
  journal = {Journal of controlled release : official journal of the Controlled Release Society},
  year    = {2024},
  doi     = {10.1016/j.jconrel.2024.01.047},
  pmid    = {38286338},
  url     = {https://doi.org/10.1016/j.jconrel.2024.01.047}
}

@article{rohilla2024-38629171,
  author  = {Rohilla, Ankur and Rohilla, Seema},
  title   = {{Drug Repositioning: A Monetary Stratagem to Discover a New Application of Drugs}},
  journal = {Current drug discovery technologies},
  year    = {2024},
  doi     = {10.2174/0115701638253929230922115127},
  pmid    = {38629171},
  url     = {https://doi.org/10.2174/0115701638253929230922115127}
}

@article{basso2024-37990896,
  author  = {Basso, Letícia and Fagundes, Silvia Cristina and Staudt, Tatiana and da Rosa, Karini and Langaro, Elizane and Omidian, Hamid and Bertol, Charise Dallazem},
  title   = {{Transdermal Therapeutic Systems for the Treatment of Alzheimer's Disease: A Patent Review}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2024},
  doi     = {10.2174/0118715273275957231102044934},
  pmid    = {37990896},
  url     = {https://doi.org/10.2174/0118715273275957231102044934}
}

@article{rhea2024-38095516,
  author  = {Rhea, E. M. and Babin, A. and Thomas, P. and Omer, M. and Weaver, R. and Hansen, K. and Banks, W. A. and Talbot, K.},
  title   = {{Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases}},
  journal = {Tissue barriers},
  year    = {2024},
  doi     = {10.1080/21688370.2023.2292461},
  pmid    = {38095516},
  url     = {https://doi.org/10.1080/21688370.2023.2292461}
}

@article{vanderoovaart2023-38004378,
  author  = {Van de Roovaart, Hannah J and Nguyen, Nguyen and Veenstra, Timothy D},
  title   = {{Huntington's Disease Drug Development: A Phase 3 Pipeline Analysis}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/ph16111513},
  pmid    = {38004378},
  url     = {https://doi.org/10.3390/ph16111513}
}

@article{basagni2023-37734258,
  author  = {Basagni, Filippo and Ortega, Jose A and Bertozzi, Sine M and Armirotti, Andrea and Summa, Maria and Bertorelli, Rosalia and Bartolini, Manuela and Mellor, Ian R and others},
  title   = {{Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties}},
  journal = {European journal of medicinal chemistry},
  year    = {2023},
  doi     = {10.1016/j.ejmech.2023.115803},
  pmid    = {37734258},
  url     = {https://doi.org/10.1016/j.ejmech.2023.115803}
}

@article{singh2023-37694498,
  author  = {Singh, Yash Pal and Kumar, Navneet and Chauhan, Brijesh Singh and Garg, Prabha},
  title   = {{Carbamate as a potential anti-Alzheimer's pharmacophore: A review}},
  journal = {Drug development research},
  year    = {2023},
  doi     = {10.1002/ddr.22113},
  pmid    = {37694498},
  url     = {https://doi.org/10.1002/ddr.22113}
}

@article{bourdakou2023-37696195,
  author  = {Bourdakou, Marilena M and Fernández-Ginés, Raquel and Cuadrado, Antonio and Spyrou, George M},
  title   = {{Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood}},
  journal = {Redox biology},
  year    = {2023},
  doi     = {10.1016/j.redox.2023.102881},
  pmid    = {37696195},
  url     = {https://doi.org/10.1016/j.redox.2023.102881}
}

@article{singh2023-37675624,
  author  = {Singh, Yash P and Kumar, Harish},
  title   = {{Tryptamine: A privileged scaffold for the management of Alzheimer's disease}},
  journal = {Drug development research},
  year    = {2023},
  doi     = {10.1002/ddr.22111},
  pmid    = {37675624},
  url     = {https://doi.org/10.1002/ddr.22111}
}

@article{weber2023-37666109,
  author  = {Weber, Patrick and Mészáros, Zuzana and Bojarová, Pavla and Ebner, Manuel and Fischer, Roland and Křen, Vladimír and Kulik, Natalia and Müller, Philipp and others},
  title   = {{Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase}},
  journal = {Bioorganic chemistry},
  year    = {2023},
  doi     = {10.1016/j.bioorg.2023.106819},
  pmid    = {37666109},
  url     = {https://doi.org/10.1016/j.bioorg.2023.106819}
}

@article{peng2023-37600514,
  author  = {Peng, Y. and Jin, H. and Xue, Y. H. and Chen, Q. and Yao, S. Y. and Du, M. Q. and Liu, S.},
  title   = {{Current and future therapeutic strategies for Alzheimer's disease: an overview of drug development bottlenecks}},
  journal = {Frontiers in aging neuroscience},
  year    = {2023},
  doi     = {10.3389/fnagi.2023.1206572},
  pmid    = {37600514},
  url     = {https://doi.org/10.3389/fnagi.2023.1206572}
}

@article{mohle2023-37508364,
  author  = {Möhle, Luisa and Stefan, Katja and Bascuñana, Pablo and Brackhan, Mirjam and Brüning, Thomas and Eiriz, Ivan and El Menuawy, Ahmed and van Genderen, Sylvie and others},
  title   = {{ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer's Disease}},
  journal = {Biology},
  year    = {2023},
  doi     = {10.3390/biology12070932},
  pmid    = {37508364},
  url     = {https://doi.org/10.3390/biology12070932}
}

@article{bayraktar2023-37210557,
  author  = {Bayraktar, Abdulahad and Li, Xiangyu and Kim, Woonghee and Zhang, Cheng and Turkez, Hasan and Shoaie, Saeed and Mardinoglu, Adil},
  title   = {{Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients}},
  journal = {Journal of translational medicine},
  year    = {2023},
  doi     = {10.1186/s12967-023-04192-6},
  pmid    = {37210557},
  url     = {https://doi.org/10.1186/s12967-023-04192-6}
}

@article{kassa2023-37051629,
  author  = {Kassa, Jiri and Karasova, Jana Zdarova},
  title   = {{Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice}},
  journal = {Toxicology mechanisms and methods},
  year    = {2023},
  doi     = {10.1080/15376516.2023.2202730},
  pmid    = {37051629},
  url     = {https://doi.org/10.1080/15376516.2023.2202730}
}

@article{jimenez2023-36677633,
  author  = {Jiménez, Elvia Mera and Żołek, Teresa and Perez, Paola Gabriela Hernández and Ruvalcaba, Rene Miranda and Nicolás-Vázquez, María Inés and Hernández-Rodríguez, Maricarmen},
  title   = {{Drug Repurposing to Inhibit Histamine N-Methyl Transferase}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/molecules28020576},
  pmid    = {36677633},
  url     = {https://doi.org/10.3390/molecules28020576}
}

@article{agarwal2023-35733313,
  author  = {Agarwal, Kritie and Katare, Deepshikha Pande and Jakhmola-Mani, Ruchi},
  title   = {{Foresee Novel Targets for Alzheimer's Disease by Investigating Repurposed Drugs}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2023},
  doi     = {10.2174/1871527321666220622162622},
  pmid    = {35733313},
  url     = {https://doi.org/10.2174/1871527321666220622162622}
}

@article{neha2023-36529440,
  author  = {Neha and Parvez, Suhel},
  title   = {{Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer's disease}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2022.101815},
  pmid    = {36529440},
  url     = {https://doi.org/10.1016/j.arr.2022.101815}
}

@article{jang2022-36440278,
  author  = {Jang, Ha Young and Oh, Jung Mi and Kim, In-Wha},
  title   = {{Drug repurposing using meta-analysis of gene expression in Alzheimer's disease}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.989174},
  pmid    = {36440278},
  url     = {https://doi.org/10.3389/fnins.2022.989174}
}

@article{nunes2022-36365114,
  author  = {Nunes, Débora and Loureiro, Joana A and Pereira, Maria Carmo},
  title   = {{Drug Delivery Systems as a Strategy to Improve the Efficacy of FDA-Approved Alzheimer's Drugs}},
  journal = {Pharmaceutics},
  year    = {2022},
  doi     = {10.3390/pharmaceutics14112296},
  pmid    = {36365114},
  url     = {https://doi.org/10.3390/pharmaceutics14112296}
}

@article{kakoti2022-36263141,
  author  = {Kakoti, Bibhuti Bhusan and Bezbaruah, Rajashri and Ahmed, Nasima},
  title   = {{Therapeutic drug repositioning with special emphasis on neurodegenerative diseases: Threats and issues}},
  journal = {Frontiers in pharmacology},
  year    = {2022},
  doi     = {10.3389/fphar.2022.1007315},
  pmid    = {36263141},
  url     = {https://doi.org/10.3389/fphar.2022.1007315}
}

@article{siddique2022-35992376,
  author  = {Siddique, Yasir Hasan and Naz, Falaq and Rahul and Varshney, Himanshi},
  title   = {{Comparative study of rivastigmine and galantamine on the transgenic Drosophila model of Alzheimer's disease}},
  journal = {Current research in pharmacology and drug discovery},
  year    = {2022},
  doi     = {10.1016/j.crphar.2022.100120},
  pmid    = {35992376},
  url     = {https://doi.org/10.1016/j.crphar.2022.100120}
}

@article{giacobini2022-35289363,
  author  = {Giacobini, E. and Cuello, A. C. and Fisher, A.},
  title   = {{Reimagining cholinergic therapy for Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awac096},
  pmid    = {35289363},
  url     = {https://doi.org/10.1093/brain/awac096}
}

@article{savva2022-35386099,
  author  = {Savva, Kyriaki and Zachariou, Margarita and Bourdakou, Marilena M and Dietis, Nikolas and Spyrou, George M},
  title   = {{Network-based stage-specific drug repurposing for Alzheimer's disease}},
  journal = {Computational and structural biotechnology journal},
  year    = {2022},
  doi     = {10.1016/j.csbj.2022.03.013},
  pmid    = {35386099},
  url     = {https://doi.org/10.1016/j.csbj.2022.03.013}
}

@article{lamptey2022-35163773,
  author  = {Lamptey, R. N. L. and Chaulagain, B. and Trivedi, R. and Gothwal, A. and Layek, B. and Singh, J.},
  title   = {{A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23031851},
  pmid    = {35163773},
  url     = {https://doi.org/10.3390/ijms23031851}
}

@article{xie2022-34992270,
  author  = {Xie, C. and Zhuang, X. X. and Niu, Z. and Ai, R. and Lautrup, S. and Zheng, S. and Jiang, Y. and Han, R. and others},
  title   = {{Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow}},
  journal = {Nature biomedical engineering},
  year    = {2022},
  doi     = {10.1038/s41551-021-00819-5},
  pmid    = {34992270},
  url     = {https://doi.org/10.1038/s41551-021-00819-5}
}

@article{sivaraman2022-34602041,
  author  = {Sivaraman, Bhuvaneswari and Raji, Vijaykumar and Velmurugan, Bala Aakash and Natarajan, Ramalakshmi},
  title   = {{Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2022},
  doi     = {10.2174/1871527320666210928160159},
  pmid    = {34602041},
  url     = {https://doi.org/10.2174/1871527320666210928160159}
}

@article{hua2022-35180125,
  author  = {Hua, Xue and Church, Kevin and Walker, William and L'Hostis, Philippe and Viardot, Geoffrey and Danjou, Philippe and Hendrix, Suzanne and Moebius, Hans J},
  title   = {{Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer's Disease: Randomized, Placebo-Controlled, Double-Blind, Phase I Clinical Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-215511},
  pmid    = {35180125},
  url     = {https://doi.org/10.3233/jad-215511}
}

@article{holm2022-35482908,
  author  = {Holm, A. and Hansen, S. N. and Klitgaard, H. and Kauppinen, S.},
  title   = {{Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases}},
  journal = {RNA biology},
  year    = {2022},
  doi     = {10.1080/15476286.2022.2066334},
  pmid    = {35482908},
  url     = {https://doi.org/10.1080/15476286.2022.2066334}
}

@article{nam2021-34482237,
  author  = {Nam, Geewoo and Suh, Jong-Min and Yi, Yelim and Lim, Mi Hee},
  title   = {{Drug repurposing: small molecules against Cu(II)-amyloid-β and free radicals}},
  journal = {Journal of inorganic biochemistry},
  year    = {2021},
  doi     = {10.1016/j.jinorgbio.2021.111592},
  pmid    = {34482237},
  url     = {https://doi.org/10.1016/j.jinorgbio.2021.111592}
}

@article{yu2021-34360973,
  author  = {Yu, T. W. and Lane, H. Y. and Lin, C. H.},
  title   = {{Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22158208},
  pmid    = {34360973},
  url     = {https://doi.org/10.3390/ijms22158208}
}

@article{athar2021-34181171,
  author  = {Athar, T. and Al Balushi, K. and Khan, S. A.},
  title   = {{Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease}},
  journal = {Molecular biology reports},
  year    = {2021},
  doi     = {10.1007/s11033-021-06512-9},
  pmid    = {34181171},
  url     = {https://doi.org/10.1007/s11033-021-06512-9}
}

@article{vargassoria2021-34118986,
  author  = {Vargas-Soria, Maria and Carranza-Naval, Maria Jose and Del Marco, Angel and Garcia-Alloza, Monica},
  title   = {{Role of liraglutide in Alzheimer's disease pathology}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00853-0},
  pmid    = {34118986},
  url     = {https://doi.org/10.1186/s13195-021-00853-0}
}

@article{ahmed2021-33915501,
  author  = {Ahmed, Sagheer and Khan, Sidrah Tariq and Zargaham, Muhammad Kazim and Khan, Arif Ullah and Khan, Saeed and Hussain, Abrar and Uddin, Jalal and Khan, Ajmal and others},
  title   = {{Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2021},
  doi     = {10.1016/j.biopha.2021.111609},
  pmid    = {33915501},
  url     = {https://doi.org/10.1016/j.biopha.2021.111609}
}

@article{zhang2021-33503372,
  author  = {Zhang, Qian Jiang and Fu, Caixia and Guo, Xinjie and Gao, Jian and Zhang, Peng and Ding, Caifeng},
  title   = {{Fluorescent Determination of Butyrylcholinesterase Activity and Its Application in Biological Imaging and Pesticide Residue Detection}},
  journal = {ACS Sensors},
  year    = {2021},
  doi     = {10.1021/acssensors.0c02398},
  pmid    = {33503372},
  url     = {https://doi.org/10.1021/acssensors.0c02398}
}

@article{liu2021-33406172,
  author  = {Liu, Chang and Luo, Yuxin and Wen, Huijie and Qi, Yanxia and Shi, Guoyue and Deng, Jingjing and Zhou, Tianshu},
  title   = {{Red-to-blue paper-based colorimetric sensor integrated with smartphone for point-of-use analysis of cerebral AChE upon Cd2+ exposure}},
  journal = {Nanoscale},
  year    = {2021},
  doi     = {10.1039/d0nr07449g},
  pmid    = {33406172},
  url     = {https://doi.org/10.1039/d0nr07449g}
}

@article{przybylowska2021-33342413,
  author  = {Przybyłowska, Maja and Dzierzbicka, Krystyna and Kowalski, Szymon and Chmielewska, Klaudia and Inkielewicz-Stepniak, Iwona},
  title   = {{Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors}},
  journal = {Current neuropharmacology},
  year    = {2021},
  doi     = {10.2174/1570159x19666201218103434},
  pmid    = {33342413},
  url     = {https://doi.org/10.2174/1570159x19666201218103434}
}

@article{viayna2021-33356266,
  author  = {Viayna, E. and Coquelle, N. and Cieslikiewicz-Bouet, M. and Cisternas, P. and Oliva, C. A. and Sánchez-López, E. and Ettcheto, M. and Bartolini, M. and others},
  title   = {{Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice}},
  journal = {Journal of medicinal chemistry},
  year    = {2021},
  doi     = {10.1021/acs.jmedchem.0c01775},
  pmid    = {33356266},
  url     = {https://doi.org/10.1021/acs.jmedchem.0c01775}
}

@article{marucci2021-33035532,
  author  = {Marucci, G. and Buccioni, M. and Ben, D. D. and Lambertucci, C. and Volpini, R. and Amenta, F.},
  title   = {{Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease}},
  journal = {Neuropharmacology},
  year    = {2021},
  doi     = {10.1016/j.neuropharm.2020.108352},
  pmid    = {33035532},
  url     = {https://doi.org/10.1016/j.neuropharm.2020.108352}
}

@article{wang2020-32928279,
  author  = {Wang, Tao and Kuang, Weihong and Chen, Wei and Xu, Wenwei and Zhang, Liming and Li, Yingjie and Li, Hailin and Peng, Ying and others},
  title   = {{A phase II randomized trial of sodium oligomannate in Alzheimer's dementia}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00678-3},
  pmid    = {32928279},
  url     = {https://doi.org/10.1186/s13195-020-00678-3}
}

@article{martins2020-32933034,
  author  = {Martins, Márcia and Silva, Renata and Pinto, Madalena M M and Sousa, Emília},
  title   = {{Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer's Disease}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2020},
  doi     = {10.3390/ph13090242},
  pmid    = {32933034},
  url     = {https://doi.org/10.3390/ph13090242}
}

@article{koola2020-32829072,
  author  = {Koola, Maju Mathew},
  title   = {{Galantamine-Memantine combination in the treatment of Alzheimer's disease and beyond}},
  journal = {Psychiatry research},
  year    = {2020},
  doi     = {10.1016/j.psychres.2020.113409},
  pmid    = {32829072},
  url     = {https://doi.org/10.1016/j.psychres.2020.113409}
}

@article{cacabelos2020-32520597,
  author  = {Cacabelos, Ramón},
  title   = {{Pharmacogenetic considerations when prescribing cholinesterase inhibitors for the treatment of Alzheimer's disease}},
  journal = {Expert opinion on drug metabolism \& toxicology},
  year    = {2020},
  doi     = {10.1080/17425255.2020.1779700},
  pmid    = {32520597},
  url     = {https://doi.org/10.1080/17425255.2020.1779700}
}

@article{yiannopoulou2020-32165850,
  author  = {Yiannopoulou, K. G. and Papageorgiou, S. G.},
  title   = {{Current and Future Treatments in Alzheimer Disease: An Update}},
  journal = {Journal of central nervous system disease},
  year    = {2020},
  doi     = {10.1177/1179573520907397},
  pmid    = {32165850},
  url     = {https://doi.org/10.1177/1179573520907397}
}

@article{conway2020-32048098,
  author  = {Conway, M. E.},
  title   = {{Alzheimer's disease: targeting the glutamatergic system}},
  journal = {Biogerontology},
  year    = {2020},
  doi     = {10.1007/s10522-020-09860-4},
  pmid    = {32048098},
  url     = {https://doi.org/10.1007/s10522-020-09860-4}
}

@article{dembitsky2020-32037088,
  author  = {Dembitsky, Valery M and Dzhemileva, Lilya and Gloriozova, Tatyana and D'yakonov, Vladimir},
  title   = {{Natural and synthetic drugs used for the treatment of the dementia}},
  journal = {Biochemical and biophysical research communications},
  year    = {2020},
  doi     = {10.1016/j.bbrc.2020.01.123},
  pmid    = {32037088},
  url     = {https://doi.org/10.1016/j.bbrc.2020.01.123}
}

@article{sharma2020-31773661,
  author  = {Sharma, Piyoosh and Tripathi, Manish Kumar and Shrivastava, Sushant Kumar},
  title   = {{Cholinesterase as a Target for Drug Development in Alzheimer's Disease}},
  journal = {Methods in molecular biology (Clifton, N.J.)},
  year    = {2020},
  doi     = {10.1007/978-1-0716-0163-1_18},
  pmid    = {31773661},
  url     = {https://doi.org/10.1007/978-1-0716-0163-1_18}
}

@article{siafaka2020-32552655,
  author  = {Siafaka, Panoraia I and Bülbül, Ece Ö and Mutlu, Gökce and Okur, Mehmet E and Karantas, Ioannis D and Okur, Neslihan Ü},
  title   = {{Transdermal Drug Delivery Systems and their Potential in Alzheimer's Disease Management}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2020},
  doi     = {10.2174/1871527319666200618150046},
  pmid    = {32552655},
  url     = {https://doi.org/10.2174/1871527319666200618150046}
}

@article{joe2019-31810978,
  author  = {Joe, E. and Ringman, J. M.},
  title   = {{Cognitive symptoms of Alzheimer's disease: clinical management and prevention}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2019},
  doi     = {10.1136/bmj.l6217},
  pmid    = {31810978},
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@article{paranjpe2019-31326236,
  author  = {Paranjpe, Manish D and Taubes, Alice and Sirota, Marina},
  title   = {{Insights into Computational Drug Repurposing for Neurodegenerative Disease}},
  journal = {Trends in pharmacological sciences},
  year    = {2019},
  doi     = {10.1016/j.tips.2019.06.003},
  pmid    = {31326236},
  url     = {https://doi.org/10.1016/j.tips.2019.06.003}
}

@article{bennett2019-31283897,
  author  = {Bennett, C. F. and Krainer, A. R. and Cleveland, D. W.},
  title   = {{Antisense Oligonucleotide Therapies for Neurodegenerative Diseases}},
  journal = {Annual review of neuroscience},
  year    = {2019},
  doi     = {10.1146/annurev-neuro-070918-050501},
  pmid    = {31283897},
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}

@article{kabir2019-31593530,
  author  = {Kabir, Md Tanvir and Uddin, Md Sahab and Begum, Mst Marium and Thangapandiyan, Shanmugam and Rahman, Md Sohanur and Aleya, Lotfi and Mathew, Bijo and Ahmed, Muniruddin and others},
  title   = {{Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning}},
  journal = {Current pharmaceutical design},
  year    = {2019},
  doi     = {10.2174/1381612825666191008103141},
  pmid    = {31593530},
  url     = {https://doi.org/10.2174/1381612825666191008103141}
}

@article{hampel2019-30569080,
  author  = {Hampel, H. and Mesulam, M. M. and Cuello, A. C. and Khachaturian, A. S. and Vergallo, A. and Farlow, M. R. and Snyder, P. J. and Giacobini, E. and others},
  title   = {{Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2019},
  doi     = {10.14283/jpad.2018.43},
  pmid    = {30569080},
  url     = {https://doi.org/10.14283/jpad.2018.43}
}

@article{hassan2019-30551512,
  author  = {Hassan, Mubashir and Raza, Hussain and Abbasi, Muhammad Athar and Moustafa, Ahmed A and Seo, Sung-Yum},
  title   = {{The exploration of novel Alzheimer's therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2019},
  doi     = {10.1016/j.biopha.2018.11.115},
  pmid    = {30551512},
  url     = {https://doi.org/10.1016/j.biopha.2018.11.115}
}

@article{dossantos2018-30405413,
  author  = {Dos Santos, T. C. and Gomes, T. M. and Pinto, B. A. S. and Camara, A. L. and Paes, A. M. A.},
  title   = {{Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy}},
  journal = {Frontiers in pharmacology},
  year    = {2018},
  doi     = {10.3389/fphar.2018.01192},
  pmid    = {30405413},
  url     = {https://doi.org/10.3389/fphar.2018.01192}
}

@article{agatonovickustrin2018-29990843,
  author  = {Agatonovic-Kustrin, Snezana and Kettle, Christine and Morton, David W},
  title   = {{A molecular approach in drug development for Alzheimer's disease}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2018},
  doi     = {10.1016/j.biopha.2018.06.147},
  pmid    = {29990843},
  url     = {https://doi.org/10.1016/j.biopha.2018.06.147}
}

@article{hampel2018-29850777,
  author  = {Hampel, H. and Mesulam, M. M. and Cuello, A. C. and Farlow, M. R. and Giacobini, E. and Grossberg, G. T. and Khachaturian, A. S. and Vergallo, A. and others},
  title   = {{The cholinergic system in the pathophysiology and treatment of Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awy132},
  pmid    = {29850777},
  url     = {https://doi.org/10.1093/brain/awy132}
}

@article{lao2019-29732929,
  author  = {Lao, K. and Ji, N. and Zhang, X. and Qiao, W. and Tang, Z. and Gou, X.},
  title   = {{Drug development for Alzheimer's disease: review}},
  journal = {Journal of drug targeting},
  year    = {2019},
  doi     = {10.1080/1061186x.2018.1474361},
  pmid    = {29732929},
  url     = {https://doi.org/10.1080/1061186x.2018.1474361}
}

@article{goyal2018-29742314,
  author  = {Goyal, Deepti and Kaur, Amandeep and Goyal, Bhupesh},
  title   = {{Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease}},
  journal = {ChemMedChem},
  year    = {2018},
  doi     = {10.1002/cmdc.201800156},
  pmid    = {29742314},
  url     = {https://doi.org/10.1002/cmdc.201800156}
}

@article{agrawal2018-29772289,
  author  = {Agrawal, M. and Saraf, S. and Antimisiaris, S. G. and Chougule, M. B. and Shoyele, S. A. and Alexander, A.},
  title   = {{Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs}},
  journal = {Journal of controlled release : official journal of the Controlled Release Society},
  year    = {2018},
  doi     = {10.1016/j.jconrel.2018.05.011},
  pmid    = {29772289},
  url     = {https://doi.org/10.1016/j.jconrel.2018.05.011}
}

@article{duraes2018-29751602,
  author  = {Durães, F. and Pinto, M. and Sousa, E.},
  title   = {{Old Drugs as New Treatments for Neurodegenerative Diseases}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2018},
  doi     = {10.3390/ph11020044},
  pmid    = {29751602},
  url     = {https://doi.org/10.3390/ph11020044}
}

@article{song2018-29670280,
  author  = {Song, X. and MØ, Jensen and Jogini, V. and Stein, R. A. and Lee, C. H. and Mchaourab, H. S. and Shaw, D. E. and Gouaux, E.},
  title   = {{Mechanism of NMDA receptor channel block by MK-801 and memantine}},
  journal = {Nature},
  year    = {2018},
  doi     = {10.1038/s41586-018-0039-9},
  pmid    = {29670280},
  url     = {https://doi.org/10.1038/s41586-018-0039-9}
}

@article{sanchezlopez2018-29587747,
  author  = {Sánchez‐López, Elena and Ettcheto, Miren and Egea, María Antonia and Espina, Marta and Cano, Amanda C. and Calpena, Ana Cristina and Camins, Antoni and Carmona-Ule, Nuria and others},
  title   = {{Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization}},
  journal = {Journal of Nanobiotechnology},
  year    = {2018},
  doi     = {10.1186/s12951-018-0356-z},
  pmid    = {29587747},
  url     = {https://doi.org/10.1186/s12951-018-0356-z}
}

@article{li2018-29486118,
  author  = {Li, Y. and Ji, W. and Lu, Z. and Liu, L. and Shi, Y. and Ma, G. and Zhang, X.},
  title   = {{Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy}},
  journal = {Journal of the American Chemical Society},
  year    = {2018},
  doi     = {10.1021/jacs.8b01641},
  pmid    = {29486118},
  url     = {https://doi.org/10.1021/jacs.8b01641}
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@article{darrigo2018-31105226,
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  title   = {{Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing}},
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  title   = {{The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents}},
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@article{pohanka2011-21731462,
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  title   = {{Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method}},
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@article{rissman2011-21388375,
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  title   = {{Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease}},
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@article{sierra2011-21098985,
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  title   = {{Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death}},
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@article{xia2010-20720132,
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  title   = {{Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses}},
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@article{prvulovic2010-20113148,
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@article{ribeiro2010-20164566,
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@article{faux2010-20164561,
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  title   = {{PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses}},
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  title   = {{Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system}},
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@article{kotermanski2009-19261873,
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  title   = {{Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine}},
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  title   = {{Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients}},
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@article{hanson2008-19091002,
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  title   = {{Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease}},
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@article{supuran2008-18167490,
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@article{wilson2008-18291351,
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  title   = {{Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease}},
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@article{munoztorrero2008-18855672,
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  title   = {{Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease}},
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  title   = {{Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease}},
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  title   = {{Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease}},
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@article{parsons2007-17904591,
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  title   = {{Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse}},
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  year    = {2007},
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  pmid    = {17904591},
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  title   = {{Effects of TC-1734 (AZD3480), a selective neuronal nicotinic receptor agonist, on cognitive performance and the EEG of young healthy male volunteers}},
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  year    = {2007},
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  pmid    = {17225162},
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@article{creeley2008-17112636,
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  title   = {{Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain}},
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  year    = {2008},
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  pmid    = {17112636},
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@article{schliebs2006-17039298,
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  title   = {{The significance of the cholinergic system in the brain during aging and in Alzheimer's disease}},
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@article{gotti2006-16876883,
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  title   = {{Brain nicotinic acetylcholine receptors: native subtypes and their relevance}},
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@article{chen2006-16805772,
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@article{lipton2006-16424917,
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  title   = {{Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond}},
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@article{robinson2006-16906789,
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  title   = {{Memantine: a review of its use in Alzheimer's disease}},
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  pmid    = {16906789},
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@article{johnson2006-16368266,
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  title   = {{Mechanism of action of memantine}},
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  year    = {2006},
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  pmid    = {16368266},
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@article{francis2005-16273023,
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@article{casida2005-16243304,
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  title   = {{Serine hydrolase targets of organophosphorus toxicants}},
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  year    = {2005},
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@article{pollak2005-15852394,
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  title   = {{Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production}},
  journal = {Annals of neurology},
  year    = {2005},
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@article{lipton2005-15974913,
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  title   = {{The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism}},
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@article{vandam2005-15654502,
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  title   = {{Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model}},
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@article{houghton2005-15956811,
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  title   = {{Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease}},
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@article{greig2004-15681814,
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  title   = {{New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists}},
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  year    = {2004},
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  pmid    = {15681814},
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@article{javitt2004-15278097,
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@article{racchi2004-15304241,
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  title   = {{Acetylcholinesterase inhibitors: novel activities of old molecules}},
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@article{hynd2004-15234100,
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  title   = {{Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease}},
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  pmid    = {15234100},
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@article{wilkinson2004-15132713,
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  title   = {{Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy}},
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  pmid    = {15132713},
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@article{danysz2003-12973747,
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  title   = {{The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence}},
  journal = {International journal of geriatric psychiatry},
  year    = {2003},
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  pmid    = {12973747},
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@article{scarpini2003-12941576,
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  title   = {{Treatment of Alzheimer's disease: current status and new perspectives}},
  journal = {The Lancet. Neurology},
  year    = {2003},
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  pmid    = {12941576},
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@article{samochocki2003-12649296,
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  title   = {{Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors}},
  journal = {The Journal of pharmacology and experimental therapeutics},
  year    = {2003},
  doi     = {10.1124/jpet.102.045773},
  pmid    = {12649296},
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@article{butterfield2003-12828500,
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  title   = {{The glutamatergic system and Alzheimer's disease: therapeutic implications}},
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  pmid    = {12828500},
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@article{rogawski2003-14530799,
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  title   = {{The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease}},
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  year    = {2003},
  doi     = {10.1111/j.1527-3458.2003.tb00254.x},
  pmid    = {14530799},
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