% alzhub.org topic: myeloid
% Source: https://alzhub.org/topic/myeloid
% 747 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{badachhape2026-78820a75,
  author  = {Badachhape, A. A. and Bhandari, P. and Khan, R. and Bhavane, R. and Menon, R. and Parekh, P. and Admane, P. and Ngan, E. and others},
  title   = {{Molecular MRI of Neuroinflammation in Alzheimer's Disease using a Folate-targeted Nanoprobe}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.27.761963},
  url     = {https://doi.org/10.64898/2026.10.27.761963}
}

@article{mercado2026-398d9a8d,
  author  = {Mercado, G. and Stetzik, L. and Schulz, E. and Meyerdirk, L. and Lindquist, A. and Cohen, L. and Escobar Galvis, M. L. and Steiner, J. A. and others},
  title   = {{Neuroinflammation is an early pathological process in a mouse model of prodromal Parkinsons disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.29.762888},
  url     = {https://doi.org/10.64898/2026.10.29.762888}
}

@article{dekleijn2026-4fee9899,
  author  = {de Kleijn, K. and Weller, S. and Klaassen, R. and Koopmans, F. and Smit, A. and Wijdeven, R.},
  title   = {{The TREM-receptor family interactome in the human brain}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.28.762136},
  url     = {https://doi.org/10.64898/2026.10.28.762136}
}

@article{devlin2026-50f6f595,
  author  = {Devlin, M. and Rodstrom, K. and Benkerdagh, C. and Ber, S. and Ramsden, N. and Rowlett, M. and Cordeiro, S. and Hayre, M. and others},
  title   = {{A Binding Site for CVN293 Reveals a Mechanism for Allosteric Control of THIK-1 K2P Channel Gating}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.27.761881},
  url     = {https://doi.org/10.64898/2026.10.27.761881}
}

@article{zott2026-90b7bcf3,
  author  = {Zott, B. and Unger, F. and Wolf, C. and Schlepckow, K. and Ulmer, N. and Rossignol, P. and Pousinha, P. and Chen, L. and others},
  title   = {{Soluble TREM2 suppresses neuronal activity}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11388834/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11388834/v1}
}

@article{quang2026-09848cb6,
  author  = {Quang, D. and Summers, R. and Dooling, B. R. and Esquer, H. and Zhou, Q. and LaBarbera, D. V. and Vergara, M. N. and Chial, H. J. and others},
  title   = {{High-content imaging of live microglia-containing Alzheimer’s disease brain organoids}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.26.761970},
  url     = {https://doi.org/10.64898/2026.10.26.761970}
}

@article{danhash2026-f606cf98,
  author  = {Danhash, E. P. and Verbeck, A. C. and Iyer, A. K. and Karch, C. M.},
  title   = {{Ms4a4a loss preferentially remodels microglia with limited, compartment-specific effects across central and peripheral immune compartments in 5xFAD mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.26.762005},
  url     = {https://doi.org/10.64898/2026.10.26.762005}
}

@article{upadhyay2026-fce28563,
  author  = {Upadhyay, S. and Zhang, L. and Kaur, B. and Calvo-Barreiro, L. and Teplova, M. and Gabr, M.},
  title   = {{Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.15.759511},
  url     = {https://doi.org/10.64898/2026.10.15.759511}
}

@article{ghosh2026-549141c1,
  author  = {Ghosh, B. and Wang, S. and Qi, C. and Ghosh, A. and Comerota, M. and Rajpurohit, C. S. and Zeldin, D. C. and Zheng, H.},
  title   = {{Astrocytic sEH–EET signaling regulates microglial lysosomal function and suppresses the STING–Type I interferon pathway in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.16.759679},
  url     = {https://doi.org/10.64898/2026.10.16.759679}
}

@article{juardar2026-b4b52380,
  author  = {Juardar, P. P. and George, K. and Roy, R. K.},
  title   = {{Protective or Pathogenic? Microglial Responses at the Intersection of Amyloid-β, Tau, and Neuroinflammation in Alzheimer’s Disease}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202610.1771.v1},
  url     = {https://doi.org/10.20944/preprints202610.1771.v1}
}

@article{tan2026-437238a8,
  author  = {Tan, Q. and Xie, A. and Chen, J. and Wei, S. and Guo, Y. and Liu, G. and Wang, L. and Liu, X. and others},
  title   = {{Electroacupuncture alleviate cognitive impairment via activation of TREM2-positive microglia in APP/PS1 mice}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11138446/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11138446/v1}
}

@article{aggarwal2026-715fc47c,
  author  = {Aggarwal, G. and Banerjee, S. and Bhadra, A. K. and Hwang, J. J. and Malabana, D. A. O. and Nagarajan, N. and Smith, D. M. and Kollarapu, J. and others},
  title   = {{Progranulin deficiency promotes neuroinflammation through cathepsin B-mediated activation of the NLRP3 inflammasome}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.11.758389},
  url     = {https://doi.org/10.64898/2026.10.11.758389}
}

@article{lee2026-ce9e4ee2,
  author  = {Lee, H. and Peppler, G. B. and Sewell, M. and Münch, A. and Podleśny-Drabiniok, A. and Kim, J. J. and Orrick, J. and Marcora, E. and others},
  title   = {{A rapid, genetically-tractable human iPSC-derived model for studying tissue-resident macrophage biology in Alzheimer’s and other diseases}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.08.757653},
  url     = {https://doi.org/10.64898/2026.10.08.757653}
}

@article{liu2026-6e29bce4,
  author  = {Liu, X. and Liu, Z. and Lv, Z. and Lei, Y. and Zhou, Z. and Xu, Z. and Duan, J. and Xing, W. and others},
  title   = {{Mechanistic study of PHLDA1 in cognitive dysfunction of Alzheimer’s disease model mice via FoxO1‑mediated neuroinflammation}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10948741/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10948741/v1}
}

@article{leon2026-1faaf0d8,
  author  = {Leon, J. and Yoshinaga, S. and Koya, I. and Palafox, G. and Ando, Y. and Kubo, K. and Moody, J. and Takao, M. and others},
  title   = {{DAP12-deficient microglia adopt a TREM2-independent antigen-presenting state with a glial-to-neuronal cascade in Nasu-Hakola disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.07.757387},
  url     = {https://doi.org/10.64898/2026.10.07.757387}
}

@article{thakur2026-ca6358d7,
  author  = {Thakur, K. and Péladeau, C. and Hewitt, M. and Baumann, K. and Cai, D. and Woulfe, J. M. and Tomlinson, J. J. and Schlossmacher, M. G. and others},
  title   = {{ASC specks and α-synuclein amplify microglial NLRP3 inflammasome activation and co-localize with Lewy body pathology}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.02.756339},
  url     = {https://doi.org/10.64898/2026.10.02.756339}
}

@article{kim2026-376fe0f8,
  author  = {Kim, N. and Jeong, D. S. and Lee, Y. and Oh, C.},
  title   = {{Human multiscale transcriptomics identifies the NLRP3 inflammasome as a convergent druggable target in Alzheimer’s disease: validation with dimethyl itaconate in 5xFAD mice}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11103693/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11103693/v1}
}

@article{huang2026-f63e9b8e,
  author  = {Huang, E. and Lu, R. and Choi, J. and Jahan, N. and Imhof, I. and Collo, S. and Eguiguren, S. and Zhang, J. and others},
  title   = {{TLR7-mediated autoimmunity targets Robo3 to drive astrogliosis in frontotemporal dementia}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11236688/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11236688/v1}
}

@article{lv2026-42865133,
  author  = {Lv, Yaqing and Shi, Mingpeng and Zhao, Yongfei and Yu, Yi and Lv, Jiawei and Zhao, Hai},
  title   = {{Context-dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer}},
  journal = {Clinical and translational medicine},
  year    = {2026},
  doi     = {10.1002/ctm2.70863},
  pmid    = {42865133},
  url     = {https://doi.org/10.1002/ctm2.70863}
}

@article{vanschaik2026-b4bfc569,
  author  = {van Schaik, M. and Lai, K. O. and Shapiro, N. L. and Jäck, A. and Goddard, J. and Crook, H. and Frohn, R. and Jones, P. S. and others},
  title   = {{Plasma immune signatures associate with neurodegeneration in frontotemporal lobar degeneration}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.26364155},
  url     = {https://doi.org/10.64898/2026.09.28.26364155}
}

@article{sharma2026-c554220d,
  author  = {Sharma, A. and Aylar, D. and Lapin, D. and Marambaud, P. and Wang, P.},
  title   = {{Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.18.752724},
  url     = {https://doi.org/10.64898/2026.09.18.752724}
}

@article{lin2026-703e2eb0,
  author  = {Lin, D. and Atkinson, JR. and Wu, W. and Chen, M. and Jayasekara, S. and Segal, B. M. and Ma, A. and Gao, J.},
  title   = {{A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.16.752098},
  url     = {https://doi.org/10.64898/2026.09.16.752098}
}

@article{antonbarros2026-0ceb195a,
  author  = {Antón-Barros, C. and Villarejo-Zori, B. and Carmona-Lorenzo, S. and Barbero-Paredes, J. M. and González-Díaz, D. and Uceda, M. and Fernàndez-Bernal, A. and Portero-Otín, M. and others},
  title   = {{A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.10.750647},
  url     = {https://doi.org/10.64898/2026.09.10.750647}
}

@article{algamal2026-005bc584,
  author  = {Algamal, M. and Yokomizo, S. and Ndambakuwa, W. and Abdallah, S. and Sanchez-Mico, M. V. and Gillani, R. and da Silva, P. and Rajput, A. and others},
  title   = {{Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.07.749938},
  url     = {https://doi.org/10.64898/2026.09.07.749938}
}

@article{kuhnau2026-4fd9d702,
  author  = {Kuhnau, L. and Jimenez, G. A. and Hack, W. and Varada, S. and Gladen-Kolarsky, N. and Kim, S. and Klein, F. and Banerji, T. and others},
  title   = {{The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.31.741838},
  url     = {https://doi.org/10.64898/2026.07.31.741838}
}

@article{rodriguez2026-ef1dd141,
  author  = {Rodríguez, E. M. and Zaragoza-Ballester, P. and Alcolea, D. and Esteller-Gauxax, D. and Nuscher, B. and Chacón, S. and Á, Fernández-León and Í, Rodríguez-Baz and others},
  title   = {{APOEε4 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodies}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10429506/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10429506/v1}
}

@article{krunic2026-ec5a997c,
  author  = {Krunic, A. and Umesh Ganesh, N. and Coskun, U. and Brennan, W. and Patel, C. and Joshi, O. and Lee, J. and Gu, T. S. and others},
  title   = {{MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer’s Disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.20.738977},
  url     = {https://doi.org/10.64898/2026.07.20.738977}
}

@article{shen2026-42489128,
  author  = {Shen, Qi and Chang, Haocai and Li, Junyu and Guo, Haoyun and Shi, Wenbin and Yan, Yihua and Ouyang, Wenwen and Zhang, Zhan and others},
  title   = {{Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag247},
  pmid    = {42489128},
  url     = {https://doi.org/10.1093/brain/awag247}
}

@article{srikanth2026-e12d5e2b,
  author  = {Srikanth, M. and Jiang, S. and Wellman, S. M. and Sarkar, S. and Lorman, D. E. and Lantin, T. and Runyan, A. M. and Kumar, M. and others},
  title   = {{Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.14.738427},
  url     = {https://doi.org/10.64898/2026.07.14.738427}
}

@article{chen2026-b03c3c29,
  author  = {Chen, X. and Munoz-Mayorga, D. and Lyu, X. and Jati, S. and Zhang, J. and Rossitto, L. and Tao, Y. and Zhao, S. and others},
  title   = {{A non-canonical androgen signaling pathway drives microglial activation and tau pathology in females}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10286730/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10286730/v1}
}

@article{balistreri2026-20d3f448,
  author  = {Balistreri, A. and Gomulinski, M. and Chapman, M. R. and Kelly, J. W.},
  title   = {{The Microglial Protein sTREM2 Inhibits the Bacterial Functional Amyloid CsgA and Suppresses Amyloid-Dependent Biofilm Formation}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.03.736422},
  url     = {https://doi.org/10.64898/2026.07.03.736422}
}

@article{zeenny2026-42377782,
  author  = {Zeenny, Marie-Noel and Salame, Ingrid and Maatouk, Lynn and Akoury, Elias},
  title   = {{Neuroinflammation and Tauopathies}},
  journal = {Molecular biology reports},
  year    = {2026},
  doi     = {10.1007/s11033-026-12253-4},
  pmid    = {42377782},
  url     = {https://doi.org/10.1007/s11033-026-12253-4}
}

@article{belmontrausch2026-42265098,
  author  = {Belmont-Rausch, Dylan M and Ludwig, Mette Q and Bentsen, Marie A and Hansen, Stine N and Secher, Anna and Holst, Dorte and Moreno, Jaime and Das, Vivek and others},
  title   = {{Semaglutide attenuates neuroinflammation in male mice}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-74038-4},
  pmid    = {42265098},
  url     = {https://doi.org/10.1038/s41467-026-74038-4}
}

@article{liao2026-42230432,
  author  = {Liao, Y. and Ye, S. and Zhao, L. and Zhou, M. and Wen, Y. and Zhu, Y. and Huang, J. and Zhang, L. and others},
  title   = {{Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies}},
  journal = {Molecular neurobiology},
  year    = {2026},
  doi     = {10.1007/s12035-026-05925-6},
  pmid    = {42230432},
  url     = {https://doi.org/10.1007/s12035-026-05925-6}
}

@article{ouyang2026-42150695,
  author  = {Ouyang, Xiaoxue and Chia, Rachel S L and Chai, Yuek Ling and Chong, Joyce R and Sim, Ming Ann and Jo, Dong-Gyu and Arumugam, Thiruma V and Sethi, Gautam and others},
  title   = {{Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia}},
  journal = {Biochemical pharmacology},
  year    = {2026},
  doi     = {10.1016/j.bcp.2026.118077},
  pmid    = {42150695},
  url     = {https://doi.org/10.1016/j.bcp.2026.118077}
}

@article{lee2026-41789727,
  author  = {Lee, Jeongmi and Cho, Yongeun and Choi, Bo Youn and Kim, Hark Kyun and Lee, Yeongyeong and Kim, Eunae and Han, Jihoon and Sul, Jae Hoon and others},
  title   = {{HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag089},
  pmid    = {41789727},
  url     = {https://doi.org/10.1093/brain/awag089}
}

@article{abdulkhaliq2026-41792456,
  author  = {Abdulkhaliq, Altaf A and Alasiri, Glowi and Kim, Bonglee and Khan, Johra and Ajoolabady, Amir and Yousof, Shimaa Mohammad and Ren, Jun and Tuomilehto, Jaakko and others},
  title   = {{TREM2 in neurodegeneration and diseases}},
  journal = {Molecular psychiatry},
  year    = {2026},
  doi     = {10.1038/s41380-026-03505-7},
  pmid    = {41792456},
  url     = {https://doi.org/10.1038/s41380-026-03505-7}
}

@article{mummery2026-41787076,
  author  = {Mummery, C. J. and Mayorga, A. J. and Simmons, A. and Chow, T. W. and Burgess, B. and Nguyen, T. and Gao, J. and Budda, B. and Park, L. Q. and Gupta, R. and Li, C. and Shi, L. and others},
  title   = {{The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial}},
  journal = {Nature Medicine},
  year    = {2026},
  doi     = {10.1038/s41591-026-04273-1},
  pmid    = {41787076},
  url     = {https://doi.org/10.1038/s41591-026-04273-1}
}

@article{konstantoulea2026-41770935,
  author  = {Konstantoulea, Katerina and Ramakers, Meine and Borrie, Sarah C and T'Syen, Dries and Moechars, Daan and Sliwinska, Malgorzata A and Pradhan, Brajabandhu and Albertini, Giulia and others},
  title   = {{Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2026},
  doi     = {10.1073/pnas.2516774123},
  pmid    = {41770935},
  url     = {https://doi.org/10.1073/pnas.2516774123}
}

@article{li2026-41734021,
  author  = {Li, Tao and Castro-Gomez, Sergio and Lucena, Pablo Botella and Vieira-Saecker, Ana and Schwartz, Stephanie and Ding, Yingying and Deng, Yushuang and Gou, Maling and others},
  title   = {{Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model}},
  journal = {The Journal of clinical investigation},
  year    = {2026},
  doi     = {10.1172/jci199818},
  pmid    = {41734021},
  url     = {https://doi.org/10.1172/jci199818}
}

@article{kim2026-41673711,
  author  = {Kim, Yeji and Ha, Tae-Young and Kondaurova, Oksana and Lee, Myung-Shik and Chang, Keun-A},
  title   = {{Microglia TFEB activation attenuates Alzheimer's disease pathology by enhancing autophagy-lysosomal function}},
  journal = {Journal of neuroinflammation},
  year    = {2026},
  doi     = {10.1186/s12974-026-03728-z},
  pmid    = {41673711},
  url     = {https://doi.org/10.1186/s12974-026-03728-z}
}

@article{feiten2026-41580393,
  author  = {Feiten, Astrid F and Dahm, Kilian and Schlepckow, Kai and van Lengerich, Bettina and Suh, Jung H and Reifschneider, Anika and Wefers, Benedikt and Bartos, Laura M and others},
  title   = {{TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68706-8},
  pmid    = {41580393},
  url     = {https://doi.org/10.1038/s41467-026-68706-8}
}

@article{gaire2026-41571675,
  author  = {Gaire, Bhakta Prasad and Koronyo, Yosef and Vit, Jean-Philippe and Hutton, Alexandre and Subedi, Lalita and Fuchs, Dieu-Trang and Swerdlow, Natalie and Rentsendorj, Altan and others},
  title   = {{Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68580-4},
  pmid    = {41571675},
  url     = {https://doi.org/10.1038/s41467-026-68580-4}
}

@article{rausch2026-a2d21860,
  author  = {Rausch, D. M. and Ludwig, M. Q. and Bentsen, M. A. and Hansen, S. N. and Secher, A. and Holst, D. and Moreno, J. and Das, V. and others},
  title   = {{Semaglutide Attenuates Neuroinflammation in Mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.01.10.698763},
  url     = {https://doi.org/10.64898/2026.01.10.698763}
}

@article{che2026-41512220,
  author  = {Che, Yanfei and Yu, Ziman and Ji, Songjie and Yang, Dan},
  title   = {{Decoding TREM2 Signaling Pathways}},
  journal = {Neurology Neuroimmunology \& Neuroinflammation},
  year    = {2026},
  doi     = {10.1212/nxi.0000000000200527},
  pmid    = {41512220},
  url     = {https://doi.org/10.1212/nxi.0000000000200527}
}

@article{rosner2026-41435829,
  author  = {Rosner, Dalya and Sun, Jiahong and Cacace, Rita and Yee, Angie and Wagh, Chaitanya and Rychkova, Anna and Dunlap, Mariah and Gulbranson, Daniel and others},
  title   = {{The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states}},
  journal = {Neuron},
  year    = {2026},
  doi     = {10.1016/j.neuron.2025.11.022},
  pmid    = {41435829},
  url     = {https://doi.org/10.1016/j.neuron.2025.11.022}
}

@article{abel2025-41446157,
  author  = {Abel, Tamar R and Pandey, Ravi S and Haber, Annat and Garceau, Dylan and Sasner, Michael and Kotredes, Kevin P and Cary, Gregory A and Oblak, Adrian and others},
  title   = {{Trem2R47H and reduced TREM2 expression both mimic human Alzheimer's disease signatures in mice}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.64898/2025.12.17.694758},
  pmid    = {41446157},
  url     = {https://doi.org/10.64898/2025.12.17.694758}
}

@article{philippe2025-41394664,
  author  = {Philippe, Tristan J and Avey, Denis R and Kearns, Nicola A and Vyas, Himanshu and De Tissera, Sashini and Xu, Jishu and Ng, Bernard and Saunders, Devin M and others},
  title   = {{A Multi-omic Atlas of Human Choroid Plexus in Alzheimer's Disease}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.1101/2025.11.23.690014},
  pmid    = {41394664},
  url     = {https://doi.org/10.1101/2025.11.23.690014}
}

@article{gallo2025-41390810,
  author  = {Gallo, Carmela and Verrillo, Lucia and Manzo, Emiliano and Cauzzi, Emma and La Barbera, Livia and Sabatino, Giuseppina and De Paolis, Maria Luisa and Sciacca, Michele Francesco Maria and others},
  title   = {{Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03634-w},
  pmid    = {41390810},
  url     = {https://doi.org/10.1186/s12974-025-03634-w}
}

@article{cho2025-41337883,
  author  = {Cho, Sungwoo and El Gaamouch, Farida and Upadhyay, Saurabh and Nada, Hossam and Kuncewicz, Katarzyna and Gabr, Moustafa T},
  title   = {{As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2025},
  doi     = {10.1016/j.biopha.2025.118862},
  pmid    = {41337883},
  url     = {https://doi.org/10.1016/j.biopha.2025.118862}
}

@article{polydoro2025-41447159,
  author  = {Polydoro, Manuela and Geric, Ivana and Zheng, Jin and Bisgaard, Tina Sommer and Comer, Ashley L. and Sans, Laura and Lu, Ashley and Vilstrup, Joachim and others},
  title   = {{A Novel TREM2 Small Molecule Agonist MTX46943 Re‐Programs Human Microglia and Reduces Amyloid Pathology In Vivo}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_100777},
  pmid    = {41447159},
  url     = {https://doi.org/10.1002/alz70859_100777}
}

@article{tuil2025-41447298,
  author  = {Tuil, Marie Emilie and Allehyany, Bshaier and Punnota, Rifa Sanjida and Edison, Paul},
  title   = {{CSF sTREM2 is associated with distinct microglial responses with separate effects on Alzheimer's pathology in the disease's trajectory}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_100766},
  pmid    = {41447298},
  url     = {https://doi.org/10.1002/alz70856_100766}
}

@article{ravichandran2025-41206011,
  author  = {Ravichandran, Kishore Aravind and Brosseron, Frederic and McManus, Róisín M and Ising, Christina and Görgen, Simon and Schmidt, Susanne V and Santarelli, Fracesco and Lee, Se Young and others},
  title   = {{Enhancing Tyro3 signaling ameliorates IL-1β production through STAT1 in Alzheimer's disease models}},
  journal = {Journal of leukocyte biology},
  year    = {2025},
  doi     = {10.1093/jleuko/qiaf157},
  pmid    = {41206011},
  url     = {https://doi.org/10.1093/jleuko/qiaf157}
}

@article{akgun2025-41444117,
  author  = {Akgün, Bilçağ and Cornejo-Olivas, Mario R and Mena, Pedro Ramon and Adams, Larry Deon and Celis, Katrina and Whitehead, Patrice G. and Hamilton‐Nelson, Kara L. and Ríos‐Pinto, Julia and others},
  title   = {{Peruvian Population Empowers Discovery of a TREM2 Missense Variant in Alzheimer Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_105970},
  pmid    = {41444117},
  url     = {https://doi.org/10.1002/alz70855_105970}
}

@article{peng2025-41261263,
  author  = {Peng, Xiao-Qian and Yang, Zi-Kang and Guo, Hong-Song and Wu, Xiang-Yuan and Ruganzu, John Bosco and Liu, Zhong-Zhong and Wu, Song-Di and Yang, Wei-Na},
  title   = {{TREM2 Alleviates Neuroinflammation and Improves Neurogenesis in ApoE-/- Mice by Regulating M1/M2 Microglial Polarization}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-05449-5},
  pmid    = {41261263},
  url     = {https://doi.org/10.1007/s12035-025-05449-5}
}

@article{abdulkhaliq2026-41213496,
  author  = {Abdulkhaliq, Altaf A and Alasiri, Glowi and Almoghrabi, Yousef and Kim, Bonglee and Khan, Johra and Ajoolabady, Amir and Ren, Jun and Tuomilehto, Jaakko and others},
  title   = {{Role of TREM2 in neuroinflammation}},
  journal = {Experimental neurology},
  year    = {2026},
  doi     = {10.1016/j.expneurol.2025.115547},
  pmid    = {41213496},
  url     = {https://doi.org/10.1016/j.expneurol.2025.115547}
}

@article{boreland2025-41205777,
  author  = {Boreland, Andrew J. and Abbo, Yara and Li, Xindi and Stillitano, Alessandro C. and Zhang, Siwei and Duan, Jubao and Pang, Zhiping P. and Hart, Ronald P.},
  title   = {{Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model}},
  journal = {Alcohol},
  year    = {2025},
  doi     = {10.1016/j.alcohol.2025.10.006},
  pmid    = {41205777},
  url     = {https://doi.org/10.1016/j.alcohol.2025.10.006}
}

@article{hovde2025-41216966,
  author  = {Hovde, Moriah J and Maaser-Hecker, Anna and Bae, Jun-Seok and Tanzi, Rudolph E},
  title   = {{Inhibition of Acyl-CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low-density lipoprotein receptor 1 (LRP1)-dependent phagocytosis of amyloid beta protein in microglia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70879},
  pmid    = {41216966},
  url     = {https://doi.org/10.1002/alz.70879}
}

@article{qi2025-41168805,
  author  = {Qi, Xiaoshan and Zhu, Kedong and Ke, Wei and Wang, Junjie and Mao, Shanping and Chen, Guiqin},
  title   = {{Roles of TREM2 in Alzheimer's disease}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00515-3},
  pmid    = {41168805},
  url     = {https://doi.org/10.1186/s40035-025-00515-3}
}

@article{xu2025-41175591,
  author  = {Xu, Ziwei and Huang, Feijun and Wu, Zheming and Xu, Ke and Huang, Liping},
  title   = {{Syringin attenuates Alzheimer's disease-associated neuroinflammation by inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.157454},
  pmid    = {41175591},
  url     = {https://doi.org/10.1016/j.phymed.2025.157454}
}

@article{pilat2026-41109213,
  author  = {Pilat, D. J. and Le, H. and Prokopenko, D. and Lin, C. J. and Eimer, W. A. and Quinti, L. and Gavrilles, E. P. and Garcia, S. N. and Heitman, S. N. and McGinty, D. and Cetinbas, M. and others},
  title   = {{The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease by impairing microglial function}},
  journal = {Neuron},
  year    = {2026},
  doi     = {10.1016/j.neuron.2025.09.032},
  pmid    = {41109213},
  url     = {https://doi.org/10.1016/j.neuron.2025.09.032}
}

@article{wang2025-41062518,
  author  = {Wang, Xiaoxuan and Tian, Haozhe and Chen, Shifei and Ying, Liangliang and Zheng, Juan and Song, Yaya and Xi, Jin and Zhang, Yuxin and others},
  title   = {{Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells}},
  journal = {Scientific reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-19015-5},
  pmid    = {41062518},
  url     = {https://doi.org/10.1038/s41598-025-19015-5}
}

@article{bedford2025-41066163,
  author  = {Bedford, Logan M and Tutrow, Kaylee D and Hooper, Karly and Messenger, Evan J and Hernandez, Melody and Lamb, Bruce T and Meyer, Jason S and Richardson, Timothy I and others},
  title   = {{Alzheimer's disease-associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell-derived microglia-like cells}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70772},
  pmid    = {41066163},
  url     = {https://doi.org/10.1002/alz.70772}
}

@article{njoku2025-41009633,
  author  = {Njoku, George Chigozie and Kanmogne, Georgette Djuidje},
  title   = {{Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer's Disease and HIV-Associated Neurocognitive Disorders}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26189069},
  pmid    = {41009633},
  url     = {https://doi.org/10.3390/ijms26189069}
}

@article{li2025-40940798,
  author  = {Li, Ling and Zheng, Xiaoxiao and Ma, Hongyue and Zhu, Mingxia and Li, Xiuli and Sun, Xiaodan and Feng, Xinhong},
  title   = {{TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14171387},
  pmid    = {40940798},
  url     = {https://doi.org/10.3390/cells14171387}
}

@article{wang2025-40847374,
  author  = {Wang, Jie and Ni, Hong and Wang, Yu and Wei, Luyao and Ding, Hanqing and Guo, Zhongzhao and Pan, Hao and Yu, Ying and others},
  title   = {{Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00501-9},
  pmid    = {40847374},
  url     = {https://doi.org/10.1186/s40035-025-00501-9}
}

@article{jin2025-40801241,
  author  = {Jin, Zhihui and Lu, Yan and Tang, Huifang and Cui, Huashun},
  title   = {{Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non-human primate models}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70472},
  pmid    = {40801241},
  url     = {https://doi.org/10.1002/alz.70472}
}

@article{danhash2025-40843775,
  author  = {Danhash, Emma P and Verbeck, Anthony C and Western, Daniel and Díaz-Pacheco, Andrea S and Galasso, Grant and You, Shih-Feng and Huang, Guangming and Starr, Emma and others},
  title   = {{Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70580},
  pmid    = {40843775},
  url     = {https://doi.org/10.1002/alz.70580}
}

@article{albanus2025-40737431,
  author  = {Albanus, Ricardo D’Oliveira and Finan, Gina M. and Brase, Logan and Sweeney, Nicholas and Kim, Tae Yeon and Chen, Shuo and Ryoo, Yeonsu and others},
  title   = {{Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease}},
  journal = {Science Translational Medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.adx0027},
  pmid    = {40737431},
  url     = {https://doi.org/10.1126/scitranslmed.adx0027}
}

@article{gomez2025-40490625,
  author  = {Gomez, Andrew R and Byun, Hyae Ran and Wu, Shaogen and Muhammad, A K M Ghulam and Ikbariyeh, Jasmine and Chen, Jaelin and Muro, Alek and Li, Lin and others},
  title   = {{Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice}},
  journal = {Nature aging},
  year    = {2025},
  doi     = {10.1038/s43587-025-00879-1},
  pmid    = {40490625},
  url     = {https://doi.org/10.1038/s43587-025-00879-1}
}

@article{guo2025-40541122,
  author  = {Guo, Minsong and Wang, Zhengqin and Zhou, Xiaogang and Yu, Chonglin and Wu, Jianming and Yu, Lu and Mi, Jianing and Ren, Fang and others},
  title   = {{Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.156928},
  pmid    = {40541122},
  url     = {https://doi.org/10.1016/j.phymed.2025.156928}
}

@article{kraller2025-40405265,
  author  = {Kraller, Markus and Faßbender, Julia and Jabali, Ammar and Kroeger, Joseph A. and Fink, Barbara and Popper, Bastian and Ungerer, Martin and Christlmeier, Miriam A.},
  title   = {{Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01759-x},
  pmid    = {40405265},
  url     = {https://doi.org/10.1186/s13195-025-01759-x}
}

@article{han2025-40400619,
  author  = {Han, Jialin and Zhang, Zhi and Zhang, Pengfei and Yu, Qian and Cheng, Qian and Lu, Zhiming and Zong, Shuai},
  title   = {{The roles of microglia and astrocytes in neuroinflammation of Alzheimer's disease}},
  journal = {Frontiers in neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1575453},
  pmid    = {40400619},
  url     = {https://doi.org/10.3389/fnins.2025.1575453}
}

@article{butovsky2025-40324382,
  author  = {Butovsky, Oleg and Rosenzweig, Neta},
  title   = {{Alzheimer's disease and age-related macular degeneration: Shared and distinct immune mechanisms}},
  journal = {Immunity},
  year    = {2025},
  doi     = {10.1016/j.immuni.2025.04.013},
  pmid    = {40324382},
  url     = {https://doi.org/10.1016/j.immuni.2025.04.013}
}

@article{olejnik2025-40405515,
  author  = {Olejnik, Beata and Ferens-Sieczkowska, Mirosława},
  title   = {{Lectins and neurodegeneration: A glycobiologist's perspective}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2025},
  doi     = {10.17219/acem/204107},
  pmid    = {40405515},
  url     = {https://doi.org/10.17219/acem/204107}
}

@article{messenger2025-40346446,
  author  = {Messenger, Evan J and Baar, Sydney A and Bedford, Logan M and Tsai, Andy P and Lin, Peter Bor-Chian and Ferguson, Chloe A and Xu, Guixiang and Wallace, Abigail and others},
  title   = {{PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70231},
  pmid    = {40346446},
  url     = {https://doi.org/10.1002/alz.70231}
}

@article{chen2025-40305572,
  author  = {Chen, Dadian and Wang, Chen and Chen, Xi and Li, Jiayu and Chen, Shuai and Li, Yanzhong and Ma, Fangling and Li, Tingting and others},
  title   = {{Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders}},
  journal = {Science translational medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.ads6111},
  pmid    = {40305572},
  url     = {https://doi.org/10.1126/scitranslmed.ads6111}
}

@article{zhang2025-40247363,
  author  = {Zhang, L. and Xiang, X. and Li, Y. and Bu, G. and Chen, X. F.},
  title   = {{TREM2 and sTREM2 in Alzheimer's disease: from mechanisms to therapies}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00834-z},
  pmid    = {40247363},
  url     = {https://doi.org/10.1186/s13024-025-00834-z}
}

@article{li2025-40260242,
  author  = {Li, Zhitao and Gong, Chunrong},
  title   = {{NLRP3 inflammasome in Alzheimer's disease: molecular mechanisms and emerging therapies}},
  journal = {Frontiers in immunology},
  year    = {2025},
  doi     = {10.3389/fimmu.2025.1583886},
  pmid    = {40260242},
  url     = {https://doi.org/10.3389/fimmu.2025.1583886}
}

@article{yagi2025-40143815,
  author  = {Yagi, Hitomi and Boeck, Myriam and Neilsen, Katherine and Yang, Jay and Ko, Minji and Tomita, Yohei and Negishi, Kazuno and Fu, Zhongjie and others},
  title   = {{Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes—Brief Report}},
  journal = {Arteriosclerosis Thrombosis and Vascular Biology},
  year    = {2025},
  doi     = {10.1161/atvbaha.124.321809},
  pmid    = {40143815},
  url     = {https://doi.org/10.1161/atvbaha.124.321809}
}

@article{chen2025-40122810,
  author  = {Chen, Kai and Li, Fuyao and Zhang, Shuwen and Chen, Yixing and Ikezu, Tadafumi C and Li, Zonghua and Martens, Yuka A and Qiao, Wenhui and others},
  title   = {{Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03420-8},
  pmid    = {40122810},
  url     = {https://doi.org/10.1186/s12974-025-03420-8}
}

@article{xu2025-40075143,
  author  = {Xu, Wen and Huang, Yi and Zhou, Rongbin},
  title   = {{NLRP3 inflammasome in neuroinflammation and central nervous system diseases}},
  journal = {Cellular \& molecular immunology},
  year    = {2025},
  doi     = {10.1038/s41423-025-01275-w},
  pmid    = {40075143},
  url     = {https://doi.org/10.1038/s41423-025-01275-w}
}

@article{cui2025-39971937,
  author  = {Cui, H. and Banerjee, S. and Xie, N. and Hussain, M. and Jaiswal, A. and Liu, H. and Kulkarni, T. and Antony, V. B. and others},
  title   = {{TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-57024-0},
  pmid    = {39971937},
  url     = {https://doi.org/10.1038/s41467-025-57024-0}
}

@article{cai2025-39945772,
  author  = {Cai, Zhangying and Wang, Shoutang and Cao, Siyan and Chen, Yun and Penati, Silvia and Peng, Vincent and Yuede, Carla M and Beatty, Wandy L and others},
  title   = {{Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control}},
  journal = {The Journal of experimental medicine},
  year    = {2025},
  doi     = {10.1084/jem.20230173},
  pmid    = {39945772},
  url     = {https://doi.org/10.1084/jem.20230173}
}

@article{martinsferreira2025-39820004,
  author  = {Martins-Ferreira, Ricardo and Calafell-Segura, Josep and Leal, Bárbara and Rodríguez-Ubreva, Javier and Martínez-Saez, Elena and Mereu, Elisabetta and Costa, Paulo Pinho E and Laguna, Ariadna and others},
  title   = {{The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-56124-1},
  pmid    = {39820004},
  url     = {https://doi.org/10.1038/s41467-025-56124-1}
}

@article{fremuth2025-39817909,
  author  = {Fremuth, L. E. and Hu, H. and van de Vlekkert, D. and Annunziata, I. and Weesner, J. A. and d'Azzo, Alessandra},
  title   = {{Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation}},
  journal = {Cell reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2024.115204},
  pmid    = {39817909},
  url     = {https://doi.org/10.1016/j.celrep.2024.115204}
}

@article{long2024-39444037,
  author  = {Long, H. and Simmons, A. and Mayorga, A. and Burgess, B. and Nguyen, T. and Budda, B. and Rychkova, A. and Rhinn, H. and others},
  title   = {{Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01599-1},
  pmid    = {39444037},
  url     = {https://doi.org/10.1186/s13195-024-01599-1}
}

@article{koychev2024-39358806,
  author  = {Koychev, Ivan and Reid, Graham and Nguyen, Maggie and Mentz, Robert J and Joyce, Dan and Shah, Svati H and Holman, Rury R},
  title   = {{Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01573-x},
  pmid    = {39358806},
  url     = {https://doi.org/10.1186/s13195-024-01573-x}
}

@article{shojaei2024-39431020,
  author  = {Shojaei, Monireh and Schaefer, Rebecca and Schlepckow, Kai and Kunze, Lea H and Struebing, Felix L and Brunner, Bettina and Willem, Michael and Bartos, Laura M and others},
  title   = {{PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies}},
  journal = {Theranostics},
  year    = {2024},
  doi     = {10.7150/thno.97149},
  pmid    = {39431020},
  url     = {https://doi.org/10.7150/thno.97149}
}

@article{bosco2025-39353548,
  author  = {Bosco, Dale B and Kremen, Vaclav and Haruwaka, Koichiro and Zhao, Shunyi and Wang, Lingxiao and Ebner, Blake A and Zheng, Jiaying and Xie, Manling and others},
  title   = {{Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus}},
  journal = {Brain, behavior, and immunity},
  year    = {2025},
  doi     = {10.1016/j.bbi.2024.09.034},
  pmid    = {39353548},
  url     = {https://doi.org/10.1016/j.bbi.2024.09.034}
}

@article{joshi2024-39215356,
  author  = {Joshi, Radhika and Brezani, Veronika and Mey, Gabrielle M and Guixé-Muntet, Sergi and Ortega-Ribera, Marti and Zhuang, Yuan and Zivny, Adam and Werneburg, Sebastian and others},
  title   = {{IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2024},
  doi     = {10.1186/s12974-024-03203-7},
  pmid    = {39215356},
  url     = {https://doi.org/10.1186/s12974-024-03203-7}
}

@article{serradas2024-39272998,
  author  = {Serradas, Maria L and Ding, Yingying and Martorell, Paula V and Kulińska, Ida and Castro-Gomez, Sergio},
  title   = {{Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease}},
  journal = {Cells},
  year    = {2024},
  doi     = {10.3390/cells13171426},
  pmid    = {39272998},
  url     = {https://doi.org/10.3390/cells13171426}
}

@article{ganguly2024-39172787,
  author  = {Ganguly, S. and Rosenthal, S. B. and Ishizuka, K. and Troutman, T. D. and Rohm, T. V. and Khader, N. and Aleman-Muench, G. and Sano, Y. and others},
  title   = {{Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2024},
  doi     = {10.1073/pnas.2405746121},
  pmid    = {39172787},
  url     = {https://doi.org/10.1073/pnas.2405746121}
}

@article{riversauty2024-39229486,
  author  = {Rivers-Auty, Jack and Hoyle, Christopher and Pointer, Ayesha and Lawrence, Catherine and Pickering-Brown, Stuart and Brough, David and Ryan, Sarah},
  title   = {{C9orf72 dipeptides activate the NLRP3 inflammasome}},
  journal = {Brain communications},
  year    = {2024},
  doi     = {10.1093/braincomms/fcae282},
  pmid    = {39229486},
  url     = {https://doi.org/10.1093/braincomms/fcae282}
}

@article{schauer2024-39090679,
  author  = {Schauer, Stephen P and Cho, Chang Hoon and Novikova, Gloriia and Roth, Gillie A and Lee, Julie and Sharma, Anup D and Foley, Alejandro R and Ng, Carl and others},
  title   = {{Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13921},
  pmid    = {39090679},
  url     = {https://doi.org/10.1002/alz.13921}
}

@article{dean2024-39032157,
  author  = {Dean, Hunter B and Greer, Rory A and Yang, Shan-Zhong and Elston, Daniel S and Brett, Thomas J and Roberson, Erik D and Song, Yuhua},
  title   = {{Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14124},
  pmid    = {39032157},
  url     = {https://doi.org/10.1002/alz.14124}
}

@article{sun2024-39062547,
  author  = {Sun, Zhongqing and Zhang, Xin and So, Kwok-Fai and Jiang, Wen and Chiu, Kin},
  title   = {{Targeting Microglia in Alzheimer's Disease: Pathogenesis and Potential Therapeutic Strategies}},
  journal = {Biomolecules},
  year    = {2024},
  doi     = {10.3390/biom14070833},
  pmid    = {39062547},
  url     = {https://doi.org/10.3390/biom14070833}
}

@article{yin2024-38915213,
  author  = {Yin, Y. and Yang, H. and Li, R. and Wu, G. and Qin, Q. and Tang, Y.},
  title   = {{A systematic review of the role of TREM2 in Alzheimer's disease}},
  journal = {Chinese medical journal},
  year    = {2024},
  doi     = {10.1097/cm9.0000000000003000},
  pmid    = {38915213},
  url     = {https://doi.org/10.1097/cm9.0000000000003000}
}

@article{cui2024-38849370,
  author  = {Cui, Y. and Chen, C. and Tang, Z. and Yuan, W. and Yue, K. and Cui, P. and Qiu, X. and Zhang, H. and others},
  title   = {{TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice}},
  journal = {Cell death \& disease},
  year    = {2024},
  doi     = {10.1038/s41419-024-06756-w},
  pmid    = {38849370},
  url     = {https://doi.org/10.1038/s41419-024-06756-w}
}

@article{wang2024-38831312,
  author  = {Wang, Xueting and Xie, Yuqi and Fan, Xiaoyang and Wu, Xiaomei and Wang, Dan and Zhu, Li},
  title   = {{Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01489-6},
  pmid    = {38831312},
  url     = {https://doi.org/10.1186/s13195-024-01489-6}
}

@article{zhong2024-38788719,
  author  = {Zhong, J. and Xing, X. and Gao, Y. and Pei, L. and Lu, C. and Sun, H. and Lai, Y. and Du, K. and others},
  title   = {{Distinct roles of TREM2 in central nervous system cancers and peripheral cancers}},
  journal = {Cancer cell},
  year    = {2024},
  doi     = {10.1016/j.ccell.2024.05.001},
  pmid    = {38788719},
  url     = {https://doi.org/10.1016/j.ccell.2024.05.001}
}

@article{wang2024-38841103,
  author  = {Wang, R. and Zhan, Y. and Zhu, W. and Yang, Q. and Pei, J.},
  title   = {{Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2024},
  doi     = {10.3389/fnagi.2024.1407980},
  pmid    = {38841103},
  url     = {https://doi.org/10.3389/fnagi.2024.1407980}
}

@article{shi2025-38769824,
  author  = {Shi, Q. and Gutierrez, R. A. and Bhat, M. A.},
  title   = {{Microglia, Trem2, and Neurodegeneration}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2025},
  doi     = {10.1177/10738584241254118},
  pmid    = {38769824},
  url     = {https://doi.org/10.1177/10738584241254118}
}

@article{diluccia2024-38758808,
  author  = {Di Luccia, B. and Molgora, M. and Khantakova, D. and Jaeger, N. and Chang, H. W. and Czepielewski, R. S. and Helmink, B. A. and Onufer, E. J. and others},
  title   = {{TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy}},
  journal = {Science immunology},
  year    = {2024},
  doi     = {10.1126/sciimmunol.adi5374},
  pmid    = {38758808},
  url     = {https://doi.org/10.1126/sciimmunol.adi5374}
}

@article{vanwetering2024-38715119,
  author  = {van Wetering, Janna and Geut, Hanne and Bol, John J and Galis, Yvon and Timmermans, Evelien and Twisk, Jos W R and Hepp, Dagmar H and Morella, Martino L and others},
  title   = {{Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies}},
  journal = {Acta neuropathologica communications},
  year    = {2024},
  doi     = {10.1186/s40478-024-01786-z},
  pmid    = {38715119},
  url     = {https://doi.org/10.1186/s40478-024-01786-z}
}

@article{patterson2024-38695172,
  author  = {Patterson, M. T. and Xu, Y. and Hillman, H. and Osinski, V. and Schrank, P. R. and Kennedy, A. E. and Barrow, F. and Zhu, A. and others},
  title   = {{Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2024},
  doi     = {10.1161/atvbaha.124.320797},
  pmid    = {38695172},
  url     = {https://doi.org/10.1161/atvbaha.124.320797}
}

@article{vandermeulen2024-38654375,
  author  = {Vandermeulen, Lina and Geric, Ivana and Fumagalli, Laura and Kreir, Mohamed and Lu, Ashley and Nonneman, Annelies and Premereur, Jessie and Wolfs, Leen and others},
  title   = {{Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-024-00725-9},
  pmid    = {38654375},
  url     = {https://doi.org/10.1186/s13024-024-00725-9}
}

@article{rachmian2024-38637622,
  author  = {Rachmian, N. and Medina, S. and Cherqui, U. and Akiva, H. and Deitch, D. and Edilbi, D. and Croese, T. and Salame, T. M. and others},
  title   = {{Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain}},
  journal = {Nature neuroscience},
  year    = {2024},
  doi     = {10.1038/s41593-024-01620-8},
  pmid    = {38637622},
  url     = {https://doi.org/10.1038/s41593-024-01620-8}
}

@article{aldalahmah2024-38626772,
  author  = {Al-Dalahmah, Osama and Lam, Matti and McInvale, Julie J and Qu, Wenhui and Nguyen, Trang and Mun, Jeong-Yeon and Kwon, Sam and Ifediora, Nkechime and others},
  title   = {{Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons}},
  journal = {Cell stem cell},
  year    = {2024},
  doi     = {10.1016/j.stem.2024.03.013},
  pmid    = {38626772},
  url     = {https://doi.org/10.1016/j.stem.2024.03.013}
}

@article{ramakrishnan2024-38613944,
  author  = {Ramakrishnan, Gautham S and Berry, William L and Pacherille, Angela and Kerr, William G and Chisholm, John D and Pedicone, Chiara and Humphrey, Mary Beth},
  title   = {{SHIP inhibition mediates select TREM2-induced microglial functions}},
  journal = {Molecular immunology},
  year    = {2024},
  doi     = {10.1016/j.molimm.2024.04.002},
  pmid    = {38613944},
  url     = {https://doi.org/10.1016/j.molimm.2024.04.002}
}

@article{hartmann2024-38528004,
  author  = {Hartmann, Jakob and Bajaj, Thomas and Otten, Joy and Klengel, Claudia and Ebert, Tim and Gellner, Anne-Kathrin and Junglas, Ellen and Hafner, Kathrin and others},
  title   = {{SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-46953-x},
  pmid    = {38528004},
  url     = {https://doi.org/10.1038/s41467-024-46953-x}
}

@article{verma2024-38507186,
  author  = {Verma, Ambika and Azhar, Gohar and Patyal, Pankaj and Zhang, Wei and Zhang, Xiaomin and Wei, Jeanne Y},
  title   = {{Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells}},
  journal = {GeroScience},
  year    = {2024},
  doi     = {10.1007/s11357-024-01117-z},
  pmid    = {38507186},
  url     = {https://doi.org/10.1007/s11357-024-01117-z}
}

@article{zhou2024-38478630,
  author  = {Zhou, L. and Qiu, X. and Meng, Z. and Liu, T. and Chen, Z. and Zhang, P. and Kuang, H. and Pan, T. and others},
  title   = {{Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adk1866},
  pmid    = {38478630},
  url     = {https://doi.org/10.1126/scitranslmed.adk1866}
}

@article{piollet2024-38974464,
  author  = {Piollet, M. and Porsch, F. and Rizzo, G. and Kapser, F. and Schulz, D. J. J. and Kiss, M. G. and Schlepckow, K. and Morenas-Rodriguez, E. and others},
  title   = {{TREM2 protects from atherosclerosis by limiting necrotic core formation}},
  journal = {Nature cardiovascular research},
  year    = {2024},
  doi     = {10.1038/s44161-024-00429-9},
  pmid    = {38974464},
  url     = {https://doi.org/10.1038/s44161-024-00429-9}
}

@article{fang2024-38617547,
  author  = {Fang, C. and Zhong, R. and Lu, S. and Yu, G. and Liu, Z. and Yan, C. and Gao, J. and Tang, Y. and others},
  title   = {{TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis}},
  journal = {International journal of biological sciences},
  year    = {2024},
  doi     = {10.7150/ijbs.91519},
  pmid    = {38617547},
  url     = {https://doi.org/10.7150/ijbs.91519}
}

@article{yin2024-38347225,
  author  = {Yin, Tao and Yesiltepe, Metin and D'Adamio, Luciano},
  title   = {{Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias}},
  journal = {EMBO reports},
  year    = {2024},
  doi     = {10.1038/s44319-024-00077-x},
  pmid    = {38347225},
  url     = {https://doi.org/10.1038/s44319-024-00077-x}
}

@article{yu2024-38289348,
  author  = {Yu, C. and Lad, E. M. and Mathew, R. and Shiraki, N. and Littleton, S. and Chen, Y. and Hou, J. and Schlepckow, K. and others},
  title   = {{Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231011},
  pmid    = {38289348},
  url     = {https://doi.org/10.1084/jem.20231011}
}

@article{zgorzynska2024-38244651,
  author  = {Zgorzynska, Emilia},
  title   = {{TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges}},
  journal = {Molecular and cellular neurosciences},
  year    = {2024},
  doi     = {10.1016/j.mcn.2024.103917},
  pmid    = {38244651},
  url     = {https://doi.org/10.1016/j.mcn.2024.103917}
}

@article{cadiz2024-38226975,
  author  = {Cadiz, Mika P and Gibson, Katelin A and Todd, Kennedi T and Nascari, David G and Massa, Nashali and Lilley, Meredith T and Olney, Kimberly C and Al-Amin, Md Mamun and others},
  title   = {{Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231363},
  pmid    = {38226975},
  url     = {https://doi.org/10.1084/jem.20231363}
}

@article{kiianitsa2024-9e48f8fa,
  author  = {Kiianitsa, K. and Lukes, M. E. and Hayes, B. J. and Brutman, J. N. and Valdmanis, P. N. and Bird, T. D. and Raskind, W. H. and Korvatska, O.},
  title   = {{TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing}},
  journal = {Brain},
  year    = {2024}
}

@article{gong2024-38182899,
  author  = {Gong, S. and Zhai, M. and Shi, J. and Yu, G. and Lei, Z. and Shi, Y. and Zeng, Y. and Ju, P. and others},
  title   = {{TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53}},
  journal = {Cell death and differentiation},
  year    = {2024},
  doi     = {10.1038/s41418-023-01252-8},
  pmid    = {38182899},
  url     = {https://doi.org/10.1038/s41418-023-01252-8}
}

@article{wang2024-38172904,
  author  = {Wang, L. and Nykänen, N. P. and Western, D. and Gorijala, P. and Timsina, J. and Li, F. and Wang, Z. and Ali, M. and others},
  title   = {{Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-023-00687-4},
  pmid    = {38172904},
  url     = {https://doi.org/10.1186/s13024-023-00687-4}
}

@article{bosco2024-38260601,
  author  = {Bosco, Dale B and Kremen, Vaclav and Haruwaka, Koichiro and Zhao, Shunyi and Wang, Lingxiao and Ebner, Blake A and Zheng, Jiaying and Dheer, Aastha and others},
  title   = {{Impaired microglial phagocytosis promotes seizure development}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2024},
  doi     = {10.1101/2023.12.31.573794},
  pmid    = {38260601},
  url     = {https://doi.org/10.1101/2023.12.31.573794}
}

@article{chiang2024-38592304,
  author  = {Chiang, Yi-Kuan and Lin, Yung-Shuan and Chen, Chun-Yu and Lirng, Jiing-Feng and Yang, Yu-Hsiu and Lee, Wei-Ju and Fuh, Jong-Ling},
  title   = {{Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2024},
  doi     = {10.1177/15333175241243183},
  pmid    = {38592304},
  url     = {https://doi.org/10.1177/15333175241243183}
}

@article{li2024-38043010,
  author  = {Li, Yunfeng and Chen, Xiongjin and Zhou, Mulan and Feng, Sifan and Peng, Xiaoping and Wang, Yan},
  title   = {{Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-230273},
  pmid    = {38043010},
  url     = {https://doi.org/10.3233/jad-230273}
}

@article{tagliatti2024-38159572,
  author  = {Tagliatti, E. and Desiato, G. and Mancinelli, S. and Bizzotto, M. and Gagliani, M. C. and Faggiani, E. and Hernández-Soto, R. and Cugurra, A. and others},
  title   = {{Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development}},
  journal = {Immunity},
  year    = {2024},
  doi     = {10.1016/j.immuni.2023.12.002},
  pmid    = {38159572},
  url     = {https://doi.org/10.1016/j.immuni.2023.12.002}
}

@article{degea2023-38162003,
  author  = {de Gea, Priscille and Benkeder, Sarah and Bouvet, Pauline and Aimard, Mélanie and Chounlamountri, Naura and Honnorat, Jérôme and Do, Le Duy and Meissirel, Claire},
  title   = {{VEGF controls microglial phagocytic response to amyloid-β}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2023},
  doi     = {10.3389/fncel.2023.1264402},
  pmid    = {38162003},
  url     = {https://doi.org/10.3389/fncel.2023.1264402}
}

@article{yofe2023-37756565,
  author  = {Yofe, I. and Shami, T. and Cohen, N. and Landsberger, T. and Sheban, F. and Stoler-Barak, L. and Yalin, A. and Phan, T. S. and others},
  title   = {{Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary}},
  journal = {Cancer discovery},
  year    = {2023},
  doi     = {10.1158/2159-8290.cd-23-0299},
  pmid    = {37756565},
  url     = {https://doi.org/10.1158/2159-8290.cd-23-0299}
}

@article{wei2024-38042110,
  author  = {Wei, W. and Zhang, L. and Xin, W. and Pan, Y. and Tatenhorst, L. and Hao, Z. and Gerner, S. T. and Huber, S. and others},
  title   = {{TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2024},
  doi     = {10.1016/j.biopha.2023.115962},
  pmid    = {38042110},
  url     = {https://doi.org/10.1016/j.biopha.2023.115962}
}

@article{chou2023-38016942,
  author  = {Chou, Vicky and Pearse, Richard V and Aylward, Aimee J and Ashour, Nancy and Taga, Mariko and Terzioglu, Gizem and Fujita, Masashi and Fancher, Seeley B and others},
  title   = {{INPP5D regulates inflammasome activation in human microglia}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-42819-w},
  pmid    = {38016942},
  url     = {https://doi.org/10.1038/s41467-023-42819-w}
}

@article{vilella2024-37967665,
  author  = {Vilella, Antonietta and Bodria, Martina and Papotti, Bianca and Zanotti, Ilaria and Zimetti, Francesca and Remaggi, Giulia and Elviri, Lisa and Potì, Francesco and others},
  title   = {{PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2024},
  doi     = {10.1016/j.bbi.2023.11.008},
  pmid    = {37967665},
  url     = {https://doi.org/10.1016/j.bbi.2023.11.008}
}

@article{jakimovski2024-37949093,
  author  = {Jakimovski, D. and Bittner, S. and Zivadinov, R. and Morrow, S. A. and Benedict, R. H. and Zipp, F. and Weinstock-Guttman, B.},
  title   = {{Multiple sclerosis}},
  journal = {Lancet (London, England)},
  year    = {2024},
  doi     = {10.1016/s0140-6736(23)01473-3},
  pmid    = {37949093},
  url     = {https://doi.org/10.1016/s0140-6736(23)01473-3}
}

@article{zhang2023-37926352,
  author  = {Zhang, Xin and Chen, Xue and Zhang, Ling and Sun, Yuqing and Liang, Ying and Li, Huan and Zhang, Yulin},
  title   = {{Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia}},
  journal = {Neurochemistry international},
  year    = {2023},
  doi     = {10.1016/j.neuint.2023.105639},
  pmid    = {37926352},
  url     = {https://doi.org/10.1016/j.neuint.2023.105639}
}

@article{huang2024-37917301,
  author  = {Huang, P. and Zhang, Z. and Zhang, P. and Feng, J. and Xie, J. and Zheng, Y. and Liang, X. and Zhu, B. and others},
  title   = {{TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells}},
  journal = {Molecular neurobiology},
  year    = {2024},
  doi     = {10.1007/s12035-023-03713-0},
  pmid    = {37917301},
  url     = {https://doi.org/10.1007/s12035-023-03713-0}
}

@article{schlepckow2023-37863592,
  author  = {Schlepckow, K. and Morenas-Rodríguez, E. and Hong, S. and Haass, C.},
  title   = {{Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease}},
  journal = {The Lancet. Neurology},
  year    = {2023},
  doi     = {10.1016/s1474-4422(23)00247-8},
  pmid    = {37863592},
  url     = {https://doi.org/10.1016/s1474-4422(23)00247-8}
}

@article{liu2023-38176932,
  author  = {Liu, Guangtong and Zhang, Linlin and Fan, Yongzhao and Ji, Wenliang},
  title   = {{The Pathogenesis in Alzheimer's Disease: TREM2 as a Potential Target}},
  journal = {Journal of integrative neuroscience},
  year    = {2023},
  doi     = {10.31083/j.jin2206150},
  pmid    = {38176932},
  url     = {https://doi.org/10.31083/j.jin2206150}
}

@article{patterson2023-38646596,
  author  = {Patterson, M. T. and Firulyova, M. M. and Xu, Y. and Hillman, H. and Bishop, C. and Zhu, A. and Hickok, G. H. and Schrank, P. R. and others},
  title   = {{Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis}},
  journal = {Nature cardiovascular research},
  year    = {2023},
  doi     = {10.1038/s44161-023-00354-3},
  pmid    = {38646596},
  url     = {https://doi.org/10.1038/s44161-023-00354-3}
}

@article{zhang2023-37865646,
  author  = {Zhang, X. and Tang, L. and Yang, J. and Meng, L. and Chen, J. and Zhou, L. and Wang, J. and Xiong, M. and others},
  title   = {{Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-42505-x},
  pmid    = {37865646},
  url     = {https://doi.org/10.1038/s41467-023-42505-x}
}

@article{han2023-37725102,
  author  = {Han, Ying-Hao and Liu, Xiao-Dong and Jin, Mei-Hua and Sun, Hu-Nan and Kwon, Taeho},
  title   = {{Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases}},
  journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]},
  year    = {2023},
  doi     = {10.1007/s00011-023-01790-4},
  pmid    = {37725102},
  url     = {https://doi.org/10.1007/s00011-023-01790-4}
}

@article{jia2023-37721665,
  author  = {Jia, Yue-Ran and Guo, Zi-Qing and Guo, Qian and Wang, Xiao-Chuan},
  title   = {{Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer's Disease}},
  journal = {Current medical science},
  year    = {2023},
  doi     = {10.1007/s11596-023-2788-4},
  pmid    = {37721665},
  url     = {https://doi.org/10.1007/s11596-023-2788-4}
}

@article{yao2023-37670126,
  author  = {Yao, Jing and Wang, Zhe and Song, Weihong and Zhang, Yun},
  title   = {{Targeting NLRP3 inflammasome for neurodegenerative disorders}},
  journal = {Molecular psychiatry},
  year    = {2023},
  doi     = {10.1038/s41380-023-02239-0},
  pmid    = {37670126},
  url     = {https://doi.org/10.1038/s41380-023-02239-0}
}

@article{sun2023-37774678,
  author  = {Sun, N. and Victor, M. B. and Park, Y. P. and Xiong, X. and Scannail, A. N. and Leary, N. and Prosper, S. and Viswanathan, S. and others},
  title   = {{Human microglial state dynamics in Alzheimer's disease progression}},
  journal = {Cell},
  year    = {2023},
  doi     = {10.1016/j.cell.2023.08.037},
  pmid    = {37774678},
  url     = {https://doi.org/10.1016/j.cell.2023.08.037}
}

@article{mamsa2023-37652164,
  author  = {Mamsa, Rumaiza and Prabhavalkar, Kedar S and Bhatt, Lokesh Kumar},
  title   = {{Crosstalk between NLRP3 inflammasome and calpain in Alzheimer's disease}},
  journal = {The European journal of neuroscience},
  year    = {2023},
  doi     = {10.1111/ejn.16139},
  pmid    = {37652164},
  url     = {https://doi.org/10.1111/ejn.16139}
}

@article{ruedacarrasco2023-37575021,
  author  = {Rueda-Carrasco, J. and Sokolova, D. and Lee, S. E. and Childs, T. and Jurčáková, N. and Crowley, G. and De Schepper, S. and Ge, J. Z. and others},
  title   = {{Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models}},
  journal = {The EMBO journal},
  year    = {2023},
  doi     = {10.15252/embj.2022113246},
  pmid    = {37575021},
  url     = {https://doi.org/10.15252/embj.2022113246}
}

@article{chen2023-37563723,
  author  = {Chen, J. and Zhu, T. and Jiang, G. and Zeng, Q. and Li, Z. and Huang, X.},
  title   = {{Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer}},
  journal = {Molecular cancer},
  year    = {2023},
  doi     = {10.1186/s12943-023-01830-x},
  pmid    = {37563723},
  url     = {https://doi.org/10.1186/s12943-023-01830-x}
}

@article{yoo2023-37541210,
  author  = {Yoo, Y. and Neumayer, G. and Shibuya, Y. and Mader, M. M. and Wernig, M.},
  title   = {{A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease}},
  journal = {Cell stem cell},
  year    = {2023},
  doi     = {10.1016/j.stem.2023.07.006},
  pmid    = {37541210},
  url     = {https://doi.org/10.1016/j.stem.2023.07.006}
}

@article{li2023-37517293,
  author  = {Li, Y. and Xu, H. and Wang, H. and Yang, K. and Luan, J. and Wang, S.},
  title   = {{TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2023},
  doi     = {10.1016/j.biopha.2023.115218},
  pmid    = {37517293},
  url     = {https://doi.org/10.1016/j.biopha.2023.115218}
}

@article{biundo2023-37626591,
  author  = {Biundo, Fabrizio and Chitu, Violeta and Gökhan, Şölen and Chen, Edward and Oppong-Asare, Jude and Stanley, E Richard},
  title   = {{Trem2 Enhances Demyelination in the Csf1r+/- Mouse Model of Leukoencephalopathy}},
  journal = {Biomedicines},
  year    = {2023},
  doi     = {10.3390/biomedicines11082094},
  pmid    = {37626591},
  url     = {https://doi.org/10.3390/biomedicines11082094}
}

@article{zhang2023-37433768,
  author  = {Zhang, W. and Xiao, D. and Mao, Q. and Xia, H.},
  title   = {{Role of neuroinflammation in neurodegeneration development}},
  journal = {Signal transduction and targeted therapy},
  year    = {2023},
  doi     = {10.1038/s41392-023-01486-5},
  pmid    = {37433768},
  url     = {https://doi.org/10.1038/s41392-023-01486-5}
}

@article{zhong2023-37442133,
  author  = {Zhong, L. and Sheng, X. and Wang, W. and Li, Y. and Zhuo, R. and Wang, K. and Zhang, L. and Hu, D. D. and others},
  title   = {{TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration}},
  journal = {Immunity},
  year    = {2023},
  doi     = {10.1016/j.immuni.2023.06.016},
  pmid    = {37442133},
  url     = {https://doi.org/10.1016/j.immuni.2023.06.016}
}

@article{gao2023-37328043,
  author  = {Gao, Dan and Hao, Jin-Ping and Li, Bo-Ya and Zheng, Ceng-Ceng and Miao, Bei-Bei and Zhang, Li and Li, Ya-Li and Li, Lin and others},
  title   = {{Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING}},
  journal = {European journal of pharmacology},
  year    = {2023},
  doi     = {10.1016/j.ejphar.2023.175809},
  pmid    = {37328043},
  url     = {https://doi.org/10.1016/j.ejphar.2023.175809}
}

@article{nott2023-37359515,
  author  = {Nott, Alexi and Holtman, Inge R},
  title   = {{Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease}},
  journal = {Frontiers in immunology},
  year    = {2023},
  doi     = {10.3389/fimmu.2023.1168539},
  pmid    = {37359515},
  url     = {https://doi.org/10.3389/fimmu.2023.1168539}
}

@article{zhou2023-37268807,
  author  = {Zhou, Ran and Chen, Shih-Heng and Zhao, Zhan and Tu, Dezhen and Song, Sheng and Wang, Yubao and Wang, Qingshan and Feng, Jing and others},
  title   = {{Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-023-03393-w},
  pmid    = {37268807},
  url     = {https://doi.org/10.1007/s12035-023-03393-w}
}

@article{wijegunawardena2023-37235776,
  author  = {Wijegunawardena, Gayani and Castillo, Erika and Henrickson, Brandy and Davis, Regan and Condello, Carlo and Wu, Haifan},
  title   = {{Total Chemical Synthesis of Glycosylated TREM2 Ectodomain}},
  journal = {ACS chemical neuroscience},
  year    = {2023},
  doi     = {10.1021/acschemneuro.3c00257},
  pmid    = {37235776},
  url     = {https://doi.org/10.1021/acschemneuro.3c00257}
}

@article{sun2023-37172094,
  author  = {Sun, R. and Han, R. and McCornack, C. and Khan, S. and Tabor, G. T. and Chen, Y. and Hou, J. and Jiang, H. and others},
  title   = {{TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma}},
  journal = {Science advances},
  year    = {2023},
  doi     = {10.1126/sciadv.ade3559},
  pmid    = {37172094},
  url     = {https://doi.org/10.1126/sciadv.ade3559}
}

@article{larosa2023-37239970,
  author  = {La Rosa, Francesca and Agostini, Simone and Piancone, Federica and Marventano, Ivana and Hernis, Ambra and Fenoglio, Chiara and Galimberti, Daniela and Scarpini, Elio and others},
  title   = {{TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24108626},
  pmid    = {37239970},
  url     = {https://doi.org/10.3390/ijms24108626}
}

@article{li2023-37165444,
  author  = {Li, Jia-Mei and Hu, Ting and Zhou, Xiao-Na and Zhang, Ting and Guo, Jia-Hui and Wang, Min-Yuan and Wu, Yi-Lin and Su, Wen-Jun and others},
  title   = {{The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02791-0},
  pmid    = {37165444},
  url     = {https://doi.org/10.1186/s12974-023-02791-0}
}

@article{guo2023-37133566,
  author  = {Guo, X. and Li, B. and Wen, C. and Zhang, F. and Xiang, X. and Nie, L. and Chen, J. and Mao, L.},
  title   = {{TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2023},
  doi     = {10.1007/s00018-023-04786-9},
  pmid    = {37133566},
  url     = {https://doi.org/10.1007/s00018-023-04786-9}
}

@article{filipello2023-37115208,
  author  = {Filipello, F. and You, S. F. and Mirfakhar, F. S. and Mahali, S. and Bollman, B. and Acquarone, M. and Korvatska, O. and Marsh, J. A. and others},
  title   = {{Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation}},
  journal = {Acta neuropathologica},
  year    = {2023},
  doi     = {10.1007/s00401-023-02568-y},
  pmid    = {37115208},
  url     = {https://doi.org/10.1007/s00401-023-02568-y}
}

@article{parhizkar2023-37099634,
  author  = {Parhizkar, S. and Gent, G. and Chen, Y. and Rensing, N. and Gratuze, M. and Strout, G. and Sviben, S. and Tycksen, E. and others},
  title   = {{Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice}},
  journal = {Science translational medicine},
  year    = {2023},
  doi     = {10.1126/scitranslmed.ade6285},
  pmid    = {37099634},
  url     = {https://doi.org/10.1126/scitranslmed.ade6285}
}

@article{park2023-37081148,
  author  = {Park, M. D. and Reyes-Torres, I. and LeBerichel, J. and Hamon, P. and LaMarche, N. M. and Hegde, S. and Belabed, M. and Troncoso, L. and others},
  title   = {{TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-023-01475-4},
  pmid    = {37081148},
  url     = {https://doi.org/10.1038/s41590-023-01475-4}
}

@article{fu2023-37190607,
  author  = {Fu, Xin-Xin and Chen, Shuai-Yu and Lian, Hui-Wen and Deng, Yang and Duan, Rui and Zhang, Ying-Dong and Jiang, Teng},
  title   = {{The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release}},
  journal = {Brain sciences},
  year    = {2023},
  doi     = {10.3390/brainsci13040642},
  pmid    = {37190607},
  url     = {https://doi.org/10.3390/brainsci13040642}
}

@article{luo2023-37003186,
  author  = {Luo, Q. and Deng, D. and Li, Y. and Shi, H. and Zhao, J. and Qian, Q. and Wang, W. and Cai, J. and others},
  title   = {{TREM2 Insufficiency Protects against Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization}},
  journal = {International immunopharmacology},
  year    = {2023},
  doi     = {10.1016/j.intimp.2023.110070},
  pmid    = {37003186},
  url     = {https://doi.org/10.1016/j.intimp.2023.110070}
}

@article{kloske2023-36975090,
  author  = {Kloske, Courtney M and Barnum, Christopher J and Batista, Andre F and Bradshaw, Elizabeth M and Brickman, Adam M and Bu, Guojun and Dennison, Jessica and Gearon, Mary D and others},
  title   = {{APOE and immunity: Research highlights}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.13020},
  pmid    = {36975090},
  url     = {https://doi.org/10.1002/alz.13020}
}

@article{molgora2023-36989543,
  author  = {Molgora, M. and Liu, Y. A. and Colonna, M. and Cella, M.},
  title   = {{TREM2: A new player in the tumor microenvironment}},
  journal = {Seminars in immunology},
  year    = {2023},
  doi     = {10.1016/j.smim.2023.101739},
  pmid    = {36989543},
  url     = {https://doi.org/10.1016/j.smim.2023.101739}
}

@article{braatz2024-36799439,
  author  = {Braatz, Charlotte and Komes, Max P and Ravichandran, Kishore Aravind and de Fragas, Matheus Garcia and Griep, Angelika and Schwartz, Stephanie and McManus, Róisín M and Heneka, Michael T},
  title   = {{NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro}},
  journal = {Journal of neurochemistry},
  year    = {2024},
  doi     = {10.1111/jnc.15778},
  pmid    = {36799439},
  url     = {https://doi.org/10.1111/jnc.15778}
}

@article{baughn2023-36927019,
  author  = {Baughn, M. W. and Melamed, Z. and López-Erauskin, J. and Beccari, M. S. and Ling, K. and Zuberi, A. and Presa, M. and Gonzalo-Gil, E. and others},
  title   = {{Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies}},
  journal = {Science (New York, N.Y.)},
  year    = {2023},
  doi     = {10.1126/science.abq5622},
  pmid    = {36927019},
  url     = {https://doi.org/10.1126/science.abq5622}
}

@article{dedios2023-36895045,
  author  = {de Dios, Cristina and Abadin, Xenia and Roca-Agujetas, Vicente and Jimenez-Martinez, Marina and Morales, Albert and Trullas, Ramon and Mari, Montserrat and Colell, Anna},
  title   = {{Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis}},
  journal = {Translational neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s40035-023-00343-3},
  pmid    = {36895045},
  url     = {https://doi.org/10.1186/s40035-023-00343-3}
}

@article{tan2023-36889359,
  author  = {Tan, J. and Fan, W. and Liu, T. and Zhu, B. and Liu, Y. and Wang, S. and Wu, J. and Liu, J. and others},
  title   = {{TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma}},
  journal = {Journal of hepatology},
  year    = {2023},
  doi     = {10.1016/j.jhep.2023.02.032},
  pmid    = {36889359},
  url     = {https://doi.org/10.1016/j.jhep.2023.02.032}
}

@article{chen2023-36018184,
  author  = {Chen, Feng and Liu, Jing and Li, Fa-Qiang and Wang, Shuai-Shuai and Zhang, Yan-Yan and Lu, Yun-Yun and Hu, Fang-Fang and Yao, Rui-Qin},
  title   = {{β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats}},
  journal = {Neural regeneration research},
  year    = {2023},
  doi     = {10.4103/1673-5374.350204},
  pmid    = {36018184},
  url     = {https://doi.org/10.4103/1673-5374.350204}
}

@article{chou2023-36865139,
  author  = {Chou, Vicky and Fancher, Seeley B and Pearse, Richard V and Lee, Hyo and Lam, Matti and Seyfried, Nicholas T and Bennett, David A and De Jager, Phillip L and others},
  title   = {{INPP5D/SHIP1 regulates inflammasome activation in human microglia}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2023},
  doi     = {10.1101/2023.02.25.530025},
  pmid    = {36865139},
  url     = {https://doi.org/10.1101/2023.02.25.530025}
}

@article{xu2023-36829205,
  author  = {Xu, J. and Zhang, L. and Li, M. and He, X. and Luo, J. and Wu, R. and Hong, Z. and Zheng, H. and others},
  title   = {{TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02741-w},
  pmid    = {36829205},
  url     = {https://doi.org/10.1186/s12974-023-02741-w}
}

@article{tran2023-36803190,
  author  = {Tran, K. M. and Kawauchi, S. and Kramár, E. A. and Rezaie, N. and Liang, H. Y. and Sakr, J. S. and Gomez-Arboledas, A. and Arreola, M. A. and others},
  title   = {{A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00598-4},
  pmid    = {36803190},
  url     = {https://doi.org/10.1186/s13024-023-00598-4}
}

@article{chen2023-36835494,
  author  = {Chen, Yi-Chun and Chang, Shih-Cheng and Lee, Yun-Shien and Ho, Wei-Min and Huang, Yu-Hua and Wu, Yah-Yuan and Chu, Yi-Chuan and Wu, Kuan-Hsuan and others},
  title   = {{TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24044085},
  pmid    = {36835494},
  url     = {https://doi.org/10.3390/ijms24044085}
}

@article{shu2023-36800288,
  author  = {Shu, Xiaoqiu and Wei, Chen and Tu, Wen-Yo and Zhong, Keke and Qi, Shuyuan and Wang, Ailian and Bai, Lei and Zhang, Shan-Xin and others},
  title   = {{Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome}},
  journal = {Cell reports},
  year    = {2023},
  doi     = {10.1016/j.celrep.2023.112133},
  pmid    = {36800288},
  url     = {https://doi.org/10.1016/j.celrep.2023.112133}
}

@article{bohlson2023-36750318,
  author  = {Bohlson, Suzanne S and Tenner, Andrea J},
  title   = {{Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation}},
  journal = {Annual review of immunology},
  year    = {2023},
  doi     = {10.1146/annurev-immunol-101921-035639},
  pmid    = {36750318},
  url     = {https://doi.org/10.1146/annurev-immunol-101921-035639}
}

@article{deschepper2023-36747024,
  author  = {De Schepper, S. and Ge, J. Z. and Sierksma, A. and Crowley, G. and Ferreira, L. S. S. and Garceau, D. and Toomey, C. E. and Sokolova, D. and others},
  title   = {{Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease}},
  journal = {Nature neuroscience},
  year    = {2023},
  doi     = {10.1038/s41593-023-01257-z},
  pmid    = {36747024},
  url     = {https://doi.org/10.1038/s41593-023-01257-z}
}

@article{qiao2023-36721205,
  author  = {Qiao, Wenhui and Chen, Yixing and Zhong, Jun and Madden, Benjamin J and Charlesworth, Cristine M and Martens, Yuka A and Liu, Chia-Chen and Knight, Joshua and others},
  title   = {{Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00599-3},
  pmid    = {36721205},
  url     = {https://doi.org/10.1186/s13024-023-00599-3}
}

@article{peng2023-36662361,
  author  = {Peng, X. and Guo, H. and Zhang, X. and Yang, Z. and Ruganzu, J. B. and Wu, X. and Bi, W. and others},
  title   = {{TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-023-03217-x},
  pmid    = {36662361},
  url     = {https://doi.org/10.1007/s12035-023-03217-x}
}

@article{liebold2023-36766683,
  author  = {Liebold, I. and Meyer, S. and Heine, M. and Kuhl, A. and Witt, J. and Eissing, L. and Fischer, A. W. and Koop, A. C. and others},
  title   = {{TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD}},
  journal = {Cells},
  year    = {2023},
  doi     = {10.3390/cells12030341},
  pmid    = {36766683},
  url     = {https://doi.org/10.3390/cells12030341}
}

@article{vanlengerich2023-36635496,
  author  = {van Lengerich, B. and Zhan, L. and Xia, D. and Chan, D. and Joy, D. and Park, J. I. and Tatarakis, D. and Calvert, M. and others},
  title   = {{A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models}},
  journal = {Nature neuroscience},
  year    = {2023},
  doi     = {10.1038/s41593-022-01240-0},
  pmid    = {36635496},
  url     = {https://doi.org/10.1038/s41593-022-01240-0}
}

@article{zhang2023-36635449,
  author  = {Zhang, K. and Wang, Y. and Chen, S. and Mao, J. and Jin, Y. and Ye, H. and Zhang, Y. and Liu, X. and others},
  title   = {{TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis}},
  journal = {Nature metabolism},
  year    = {2023},
  doi     = {10.1038/s42255-022-00715-5},
  pmid    = {36635449},
  url     = {https://doi.org/10.1038/s42255-022-00715-5}
}

@article{biel2023-36620941,
  author  = {Biel, D. and Suárez-Calvet, M. and Hager, P. and Rubinski, A. and Dewenter, A. and Steward, A. and Roemer, S. and Ewers, M. and others},
  title   = {{sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease}},
  journal = {EMBO molecular medicine},
  year    = {2023},
  doi     = {10.15252/emmm.202216987},
  pmid    = {36620941},
  url     = {https://doi.org/10.15252/emmm.202216987}
}

@article{chu2023-37525057,
  author  = {Chu, Yung Ning and Akahori, Aika and Takatori, Sho and Tomita, Taisuke},
  title   = {{Pathological Roles of INPP5D in Alzheimer's Disease}},
  journal = {Advances in experimental medicine and biology},
  year    = {2023},
  doi     = {10.1007/978-3-031-31978-5_30},
  pmid    = {37525057},
  url     = {https://doi.org/10.1007/978-3-031-31978-5_30}
}

@article{hou2022-36564824,
  author  = {Hou, J. and Chen, Y. and Grajales-Reyes, G. and Colonna, M.},
  title   = {{TREM2 dependent and independent functions of microglia in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00588-y},
  pmid    = {36564824},
  url     = {https://doi.org/10.1186/s13024-022-00588-y}
}

@article{zhao2022-36519540,
  author  = {Zhao, A. and Jiao, Y. and Ye, G. and Kang, W. and Tan, L. and Li, Y. and Deng, Y. and Liu, J. and others},
  title   = {{Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease}},
  journal = {The Journal of clinical investigation},
  year    = {2022},
  doi     = {10.1172/jci158708},
  pmid    = {36519540},
  url     = {https://doi.org/10.1172/jci158708}
}

@article{wang2023-36521495,
  author  = {Wang, X. and He, Q. and Zhou, C. and Xu, Y. and Liu, D. and Fujiwara, N. and Kubota, N. and Click, A. and others},
  title   = {{Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development}},
  journal = {Immunity},
  year    = {2023},
  doi     = {10.1016/j.immuni.2022.11.013},
  pmid    = {36521495},
  url     = {https://doi.org/10.1016/j.immuni.2022.11.013}
}

@article{moonen2023-36481964,
  author  = {Moonen, Sebastiaan and Koper, Marta J and Van Schoor, Evelien and Schaeverbeke, Jolien M and Vandenberghe, Rik and von Arnim, Christine A F and Tousseyn, Thomas and De Strooper, Bart and others},
  title   = {{Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons}},
  journal = {Acta neuropathologica},
  year    = {2023},
  doi     = {10.1007/s00401-022-02528-y},
  pmid    = {36481964},
  url     = {https://doi.org/10.1007/s00401-022-02528-y}
}

@article{yang2023-36259513,
  author  = {Yang, T. and Zhang, S. and Yuan, H. and Wang, Y. and Cai, L. and Chen, H. and Wang, X. and Song, D. and others},
  title   = {{Platinum-Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2023},
  doi     = {10.1002/anie.202213337},
  pmid    = {36259513},
  url     = {https://doi.org/10.1002/anie.202213337}
}

@article{rikos2024-36408688,
  author  = {Rikos, D. and Siokas, V. and Mentis, A. A. and Aloizou, A. M. and Liampas, I. and Tsouris, Z. and Peristeri, E. and Stamati, P. and others},
  title   = {{TREM2 R47H variant and risk for Alzheimer's disease: assessment in a Greek population and updated meta-analysis}},
  journal = {The International journal of neuroscience},
  year    = {2024},
  doi     = {10.1080/00207454.2022.2150844},
  pmid    = {36408688},
  url     = {https://doi.org/10.1080/00207454.2022.2150844}
}

@article{yan2022-36463233,
  author  = {Yan, J. and Zhang, Y. and Wang, L. and Li, Z. and Tang, S. and Wang, Y. and Gu, N. and Sun, X. and others},
  title   = {{TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02651-3},
  pmid    = {36463233},
  url     = {https://doi.org/10.1186/s12974-022-02651-3}
}

@article{amanollahi2023-36383328,
  author  = {Amanollahi, M. and Jameie, M. and Heidari, A. and Rezaei, N.},
  title   = {{The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-022-03102-z},
  pmid    = {36383328},
  url     = {https://doi.org/10.1007/s12035-022-03102-z}
}

@article{gratuze2023-36368315,
  author  = {Gratuze, M. and Schlachetzki, J. C. M. and D'Oliveira Albanus, R. and Jain, N. and Novotny, B. and Brase, L. and Rodriguez, L. and Mansel, C. and others},
  title   = {{TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4}},
  journal = {Neuron},
  year    = {2023},
  doi     = {10.1016/j.neuron.2022.10.022},
  pmid    = {36368315},
  url     = {https://doi.org/10.1016/j.neuron.2022.10.022}
}

@article{shi2022-36408515,
  author  = {Shi, Xiaolei and Zhong, Xiaomei and Zhou, Huarong and Zhou, Nan and Hu, Yachun and Ning, Yuping and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum}},
  journal = {Frontiers in neurology},
  year    = {2022},
  doi     = {10.3389/fneur.2022.961842},
  pmid    = {36408515},
  url     = {https://doi.org/10.3389/fneur.2022.961842}
}

@article{wood2022-36417868,
  author  = {Wood, J. I. and Wong, E. and Joghee, R. and Balbaa, A. and Vitanova, K. S. and Stringer, K. M. and Vanshoiack, A. and Phelan, S. J. and others},
  title   = {{Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology}},
  journal = {Cell reports},
  year    = {2022},
  doi     = {10.1016/j.celrep.2022.111686},
  pmid    = {36417868},
  url     = {https://doi.org/10.1016/j.celrep.2022.111686}
}

@article{yu2023-36318443,
  author  = {Yu, Chao-Ji and Wang, Meng and Li, Rui-Yang and Wei, Tao and Yang, Han-Chen and Yin, Yun-Si and Mi, Ying-Xin and Qin, Qi and others},
  title   = {{TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-022-03100-1},
  pmid    = {36318443},
  url     = {https://doi.org/10.1007/s12035-022-03100-1}
}

@article{katsumoto2022-36389767,
  author  = {Katsumoto, Atsuko and Kokiko-Cochran, Olga N and Bemiller, Shane M and Xu, Guixiang and Ransohoff, Richard M and Lamb, Bruce T},
  title   = {{Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.978423},
  pmid    = {36389767},
  url     = {https://doi.org/10.3389/fimmu.2022.978423}
}

@article{he2022-36316319,
  author  = {He, L. and Zheng, Y. and Huang, L. and Ye, J. and Ye, Y. and Luo, H. and Chen, X. and Yao, W. and others},
  title   = {{Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice}},
  journal = {Translational psychiatry},
  year    = {2022},
  doi     = {10.1038/s41398-022-02227-y},
  pmid    = {36316319},
  url     = {https://doi.org/10.1038/s41398-022-02227-y}
}

@article{merighi2022-36361780,
  author  = {Merighi, Stefania and Nigro, Manuela and Travagli, Alessia and Gessi, Stefania},
  title   = {{Microglia and Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms232112990},
  pmid    = {36361780},
  url     = {https://doi.org/10.3390/ijms232112990}
}

@article{yang2022-36353359,
  author  = {Yang, J. and Ran, M. and Li, H. and Lin, Y. and Ma, K. and Yang, Y. and Fu, X. and Yang, S.},
  title   = {{New insight into neurological degeneration: Inflammatory cytokines and blood-brain barrier}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2022},
  doi     = {10.3389/fnmol.2022.1013933},
  pmid    = {36353359},
  url     = {https://doi.org/10.3389/fnmol.2022.1013933}
}

@article{kann2022-36283867,
  author  = {Kann, O. and Almouhanna, F. and Chausse, B.},
  title   = {{Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration}},
  journal = {Trends in neurosciences},
  year    = {2022},
  doi     = {10.1016/j.tins.2022.10.007},
  pmid    = {36283867},
  url     = {https://doi.org/10.1016/j.tins.2022.10.007}
}

@article{satohasahara2022-36272585,
  author  = {Satoh-Asahara, N. and Yamakage, H. and Tanaka, M. and Kawasaki, T. and Matsuura, S. and Tatebe, H. and Akiguchi, I. and Tokuda, T.},
  title   = {{Soluble TREM2 and Alzheimer-related biomarker trajectories in the blood of patients with diabetes based on their cognitive status}},
  journal = {Diabetes research and clinical practice},
  year    = {2022},
  doi     = {10.1016/j.diabres.2022.110121},
  pmid    = {36272585},
  url     = {https://doi.org/10.1016/j.diabres.2022.110121}
}

@article{bandow2022-36283335,
  author  = {Bandow, Kenjiro and Smith, Avi and Garlick, Jonathan},
  title   = {{Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) positively regulates lipopolysaccharide-induced expression of CXC chemokine ligand 10 and 11 in mouse macrophages}},
  journal = {Biochemical and biophysical research communications},
  year    = {2022},
  doi     = {10.1016/j.bbrc.2022.10.048},
  pmid    = {36283335},
  url     = {https://doi.org/10.1016/j.bbrc.2022.10.048}
}

@article{jain2023-36219197,
  author  = {Jain, N. and Lewis, C. A. and Ulrich, J. D. and Holtzman, D. M.},
  title   = {{Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading}},
  journal = {The Journal of experimental medicine},
  year    = {2023},
  doi     = {10.1084/jem.20220654},
  pmid    = {36219197},
  url     = {https://doi.org/10.1084/jem.20220654}
}

@article{wang2022-36306735,
  author  = {Wang, S. and Sudan, R. and Peng, V. and Zhou, Y. and Du, S. and Yuede, C. M. and Lei, T. and Hou, J. and others},
  title   = {{TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways}},
  journal = {Cell},
  year    = {2022},
  doi     = {10.1016/j.cell.2022.09.033},
  pmid    = {36306735},
  url     = {https://doi.org/10.1016/j.cell.2022.09.033}
}

@article{zhao2022-36107206,
  author  = {Zhao, N. and Qiao, W. and Li, F. and Ren, Y. and Zheng, J. and Martens, Y. A. and Wang, X. and Li, L. and others},
  title   = {{Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia}},
  journal = {The Journal of experimental medicine},
  year    = {2022},
  doi     = {10.1084/jem.20212479},
  pmid    = {36107206},
  url     = {https://doi.org/10.1084/jem.20212479}
}

@article{kosyreva2022-36138973,
  author  = {Kosyreva, Anna Mikhailovna and Sentyabreva, Alexandra Vladislavovna and Tsvetkov, Ivan Sergeevich and Makarova, Olga Vasilievna},
  title   = {{Alzheimer's Disease and Inflammaging}},
  journal = {Brain sciences},
  year    = {2022},
  doi     = {10.3390/brainsci12091237},
  pmid    = {36138973},
  url     = {https://doi.org/10.3390/brainsci12091237}
}

@article{zhao2022-36070367,
  author  = {Zhao, P. and Xu, Y. and Jiang, L. and Fan, X. and Li, L. and Li, X. and Arase, H. and Zhao, Y. and others},
  title   = {{A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease}},
  journal = {Science translational medicine},
  year    = {2022},
  doi     = {10.1126/scitranslmed.abq0095},
  pmid    = {36070367},
  url     = {https://doi.org/10.1126/scitranslmed.abq0095}
}

@article{wang2022-36068223,
  author  = {Wang, Y. and Cao, C. and Zhu, Y. and Fan, H. and Liu, Q. and Liu, Y. and Chen, K. and Wu, Y. and others},
  title   = {{TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria}},
  journal = {Cell death \& disease},
  year    = {2022},
  doi     = {10.1038/s41419-022-05193-x},
  pmid    = {36068223},
  url     = {https://doi.org/10.1038/s41419-022-05193-x}
}

@article{wolf2022-36119485,
  author  = {Wolf, Elysa M and Fingleton, Barbara and Hasty, Alyssa H},
  title   = {{The therapeutic potential of TREM2 in cancer}},
  journal = {Frontiers in oncology},
  year    = {2022},
  doi     = {10.3389/fonc.2022.984193},
  pmid    = {36119485},
  url     = {https://doi.org/10.3389/fonc.2022.984193}
}

@article{zhu2022-36056435,
  author  = {Zhu, B. and Liu, Y. and Hwang, S. and Archuleta, K. and Huang, H. and Campos, A. and Murad, R. and Piña-Crespo, J. and others},
  title   = {{Trem2 deletion enhances tau dispersion and pathology through microglia exosomes}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00562-8},
  pmid    = {36056435},
  url     = {https://doi.org/10.1186/s13024-022-00562-8}
}

@article{han2022-36041498,
  author  = {Han, X. and Cheng, X. and Xu, J. and Liu, Y. and Zhou, J. and Jiang, L. and Gu, X. and Xia, T.},
  title   = {{Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice}},
  journal = {Neuropharmacology},
  year    = {2022},
  doi     = {10.1016/j.neuropharm.2022.109231},
  pmid    = {36041498},
  url     = {https://doi.org/10.1016/j.neuropharm.2022.109231}
}

@article{hauremirande2022-36002854,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Ehrlich, M. E. and Gandy, S.},
  title   = {{Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00552-w},
  pmid    = {36002854},
  url     = {https://doi.org/10.1186/s13024-022-00552-w}
}

@article{barczuk2022-36012243,
  author  = {Barczuk, Julia and Siwecka, Natalia and Lusa, Weronika and Rozpędek-Kamińska, Wioletta and Kucharska, Ewa and Majsterek, Ireneusz},
  title   = {{Targeting NLRP3-Mediated Neuroinflammation in Alzheimer's Disease Treatment}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23168979},
  pmid    = {36012243},
  url     = {https://doi.org/10.3390/ijms23168979}
}

@article{gong2022-36017373,
  author  = {Gong, Ting and Chen, Qi and Mao, Hongchen and Zhang, Yao and Ren, Huan and Xu, Mengmeng and Chen, Hong and Yang, Deqin},
  title   = {{Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice}},
  journal = {Frontiers in cellular and infection microbiology},
  year    = {2022},
  doi     = {10.3389/fcimb.2022.925435},
  pmid    = {36017373},
  url     = {https://doi.org/10.3389/fcimb.2022.925435}
}

@article{jung2022-35933399,
  author  = {Jung, S. H. and Hwang, B. H. and Shin, S. and Park, E. H. and Park, S. H. and Kim, C. W. and Kim, E. and Choo, E. and others},
  title   = {{Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts}},
  journal = {Nature communications},
  year    = {2022},
  doi     = {10.1038/s41467-022-32284-2},
  pmid    = {35933399},
  url     = {https://doi.org/10.1038/s41467-022-32284-2}
}

@article{dabla2022-35924849,
  author  = {Dabla, A. and Liang, Y. C. and Rajabalee, N. and Irwin, C. and Moonen, C. G. J. and Willis, J. V. and Berton, S. and Sun, J.},
  title   = {{TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages}},
  journal = {mBio},
  year    = {2022},
  doi     = {10.1128/mbio.01456-22},
  pmid    = {35924849},
  url     = {https://doi.org/10.1128/mbio.01456-22}
}

@article{boudesco2022-35912412,
  author  = {Boudesco, Christophe and Nonneman, Annelies and Cinti, Alessandro and Picardi, Paola and Redaelli, Loredana and Swijsen, Sofie and Roewe, Julian and Reinhardt, Peter and others},
  title   = {{Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells}},
  journal = {Glia},
  year    = {2022},
  doi     = {10.1002/glia.24252},
  pmid    = {35912412},
  url     = {https://doi.org/10.1002/glia.24252}
}

@article{do2022-35867799,
  author  = {Do, T. H. and Ma, F. and Andrade, P. R. and Teles, R. and de Andrade Silva, B. J. and Hu, C. and Espinoza, A. and Hsu, J. E. and others},
  title   = {{TREM2 macrophages induced by human lipids drive inflammation in acne lesions}},
  journal = {Science immunology},
  year    = {2022},
  doi     = {10.1126/sciimmunol.abo2787},
  pmid    = {35867799},
  url     = {https://doi.org/10.1126/sciimmunol.abo2787}
}

@article{indirachandran2023-35712786,
  author  = {Indira Chandran, V. and Wernberg, C. W. and Lauridsen, M. M. and Skytthe, M. K. and Bendixen, S. M. and Larsen, F. T. and Hansen, C. D. and Grønkjær, L. L. and others},
  title   = {{Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness}},
  journal = {Hepatology (Baltimore, Md.)},
  year    = {2023},
  doi     = {10.1002/hep.32620},
  pmid    = {35712786},
  url     = {https://doi.org/10.1002/hep.32620}
}

@article{fracassi2023-35816404,
  author  = {Fracassi, A. and Marcatti, M. and Tumurbaatar, B. and Woltjer, R. and Moreno, S. and Taglialatela, G.},
  title   = {{TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2023},
  doi     = {10.1111/bpa.13108},
  pmid    = {35816404},
  url     = {https://doi.org/10.1111/bpa.13108}
}

@article{freitag2022-35780157,
  author  = {Freitag, Kiara and Sterczyk, Nele and Wendlinger, Sarah and Obermayer, Benedikt and Schulz, Julia and Farztdinov, Vadim and Mülleder, Michael and Ralser, Markus and others},
  title   = {{Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02534-7},
  pmid    = {35780157},
  url     = {https://doi.org/10.1186/s12974-022-02534-7}
}

@article{jin2022-35803230,
  author  = {Jin, M. and Xu, R. and Wang, L. and Alam, M. M. and Ma, Z. and Zhu, S. and Martini, A. C. and Jadali, A. and others},
  title   = {{Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease}},
  journal = {Cell stem cell},
  year    = {2022},
  doi     = {10.1016/j.stem.2022.06.007},
  pmid    = {35803230},
  url     = {https://doi.org/10.1016/j.stem.2022.06.007}
}

@article{wendimu2022-35805174,
  author  = {Wendimu, M. Y. and Hooks, S. B.},
  title   = {{Microglia Phenotypes in Aging and Neurodegenerative Diseases}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11132091},
  pmid    = {35805174},
  url     = {https://doi.org/10.3390/cells11132091}
}

@article{schwarz2022-35752274,
  author  = {Schwarz, Hannah and Bässler, Sarah and Balta, Denise and Socher, Eileen and Zunke, Friederike and Arnold, Philipp},
  title   = {{The role of triggering receptor expressed on myeloid cells 2 in Parkinson's disease and other neurodegenerative disorders}},
  journal = {Behavioural brain research},
  year    = {2022},
  doi     = {10.1016/j.bbr.2022.113977},
  pmid    = {35752274},
  url     = {https://doi.org/10.1016/j.bbr.2022.113977}
}

@article{hendrikx2022-35750138,
  author  = {Hendrikx, T. and Porsch, F. and Kiss, M. G. and Rajcic, D. and Papac-Miličević, N. and Hoebinger, C. and Goederle, L. and Hladik, A. and others},
  title   = {{Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH}},
  journal = {Journal of hepatology},
  year    = {2022},
  doi     = {10.1016/j.jhep.2022.06.004},
  pmid    = {35750138},
  url     = {https://doi.org/10.1016/j.jhep.2022.06.004}
}

@article{zhao2022-35717259,
  author  = {Zhao, P. and Xu, Y. and Jiang, L. L. and Fan, X. and Ku, Z. and Li, L. and Liu, X. and Deng, M. and others},
  title   = {{LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00550-y},
  pmid    = {35717259},
  url     = {https://doi.org/10.1186/s13024-022-00550-y}
}

@article{jantti2022-35706029,
  author  = {Jäntti, H. and Sitnikova, V. and Ishchenko, Y. and Shakirzyanova, A. and Giudice, L. and Ugidos, I. F. and Gómez-Budia, M. and Korvenlaita, N. and others},
  title   = {{Microglial amyloid beta clearance is driven by PIEZO1 channels}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02486-y},
  pmid    = {35706029},
  url     = {https://doi.org/10.1186/s12974-022-02486-y}
}

@article{khantakova2022-35746551,
  author  = {Khantakova, D. and Brioschi, S. and Molgora, M.},
  title   = {{Exploring the Impact of TREM2 in Tumor-Associated Macrophages}},
  journal = {Vaccines},
  year    = {2022},
  doi     = {10.3390/vaccines10060943},
  pmid    = {35746551},
  url     = {https://doi.org/10.3390/vaccines10060943}
}

@article{rajesh2022-35741014,
  author  = {Rajesh, Y. and Kanneganti, T. D.},
  title   = {{Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11121885},
  pmid    = {35741014},
  url     = {https://doi.org/10.3390/cells11121885}
}

@article{shi2022-35672148,
  author  = {Shi, Q. and Chang, C. and Saliba, A. and Bhat, M. A.},
  title   = {{Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2022},
  doi     = {10.1523/jneurosci.2427-21.2022},
  pmid    = {35672148},
  url     = {https://doi.org/10.1523/jneurosci.2427-21.2022}
}

@article{essex2022-35575023,
  author  = {Essex, Alyson L and Huot, Joshua R and Deosthale, Padmini and Wagner, Alison and Figueras, Jorge and Davis, Azaria and Damrath, John and Pin, Fabrizio and others},
  title   = {{Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice}},
  journal = {Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year    = {2022},
  doi     = {10.1002/jbmr.4572},
  pmid    = {35575023},
  url     = {https://doi.org/10.1002/jbmr.4572}
}

@article{li2022-35658903,
  author  = {Li, R. Y. and Qin, Q. and Yang, H. C. and Wang, Y. Y. and Mi, Y. X. and Yin, Y. S. and Wang, M. and Yu, C. J. and others},
  title   = {{TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00542-y},
  pmid    = {35658903},
  url     = {https://doi.org/10.1186/s13024-022-00542-y}
}

@article{jung2022-35474599,
  author  = {Jung, Eun Sun and Suh, Kyujin and Han, Jihui and Kim, Heyyoung and Kang, Hyung-Sik and Choi, Won-Seok and Mook-Jung, Inhee},
  title   = {{Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway}},
  journal = {Aging cell},
  year    = {2022},
  doi     = {10.1111/acel.13623},
  pmid    = {35474599},
  url     = {https://doi.org/10.1111/acel.13623}
}

@article{cornell2022-34472455,
  author  = {Cornell, J. and Salinas, S. and Huang, H. Y. and Zhou, M.},
  title   = {{Microglia regulation of synaptic plasticity and learning and memory}},
  journal = {Neural regeneration research},
  year    = {2022},
  doi     = {10.4103/1673-5374.322423},
  pmid    = {34472455},
  url     = {https://doi.org/10.4103/1673-5374.322423}
}

@article{morenasrodriguez2022-35305339,
  author  = {Morenas-Rodríguez, E. and Li, Y. and Nuscher, B. and Franzmeier, N. and Xiong, C. and Suárez-Calvet, M. and Fagan, A. M. and Schultz, S. and others},
  title   = {{Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study}},
  journal = {The Lancet. Neurology},
  year    = {2022},
  doi     = {10.1016/s1474-4422(22)00027-8},
  pmid    = {35305339},
  url     = {https://doi.org/10.1016/s1474-4422(22)00027-8}
}

@article{amin2022-35314318,
  author  = {Amin, Jay and Erskine, Daniel and Donaghy, Paul C and Surendranathan, Ajenthan and Swann, Peter and Kunicki, Amy P and Boche, Delphine and Holmes, Clive and others},
  title   = {{Inflammation in dementia with Lewy bodies}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105698},
  pmid    = {35314318},
  url     = {https://doi.org/10.1016/j.nbd.2022.105698}
}

@article{pan2022-35303422,
  author  = {Pan, R. Y. and He, L. and Zhang, J. and Liu, X. and Liao, Y. and Gao, J. and Yan, Y. and others},
  title   = {{Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease}},
  journal = {Cell metabolism},
  year    = {2022},
  doi     = {10.1016/j.cmet.2022.02.013},
  pmid    = {35303422},
  url     = {https://doi.org/10.1016/j.cmet.2022.02.013}
}

@article{zhou2022-35359989,
  author  = {Zhou, L. and Wang, M. and Guo, H. and Hou, J. and Zhang, Y. and Li, M. and Wu, X. and Chen, X. and others},
  title   = {{Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.848367},
  pmid    = {35359989},
  url     = {https://doi.org/10.3389/fimmu.2022.848367}
}

@article{zhang2022-35278107,
  author  = {Zhang, H. and Liu, Z. and Wen, H. and Guo, Y. and Xu, F. and Zhu, Q. and Yuan, W. and Luo, R. and others},
  title   = {{Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer}},
  journal = {Cancer immunology, immunotherapy : CII},
  year    = {2022},
  doi     = {10.1007/s00262-022-03173-w},
  pmid    = {35278107},
  url     = {https://doi.org/10.1007/s00262-022-03173-w}
}

@article{jairaman2022-35191835,
  author  = {Jairaman, A. and McQuade, A. and Granzotto, A. and Kang, Y. J. and Chadarevian, J. P. and Gandhi, S. and Parker, I. and Smith, I. and others},
  title   = {{TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia}},
  journal = {eLife},
  year    = {2022},
  doi     = {10.7554/elife.73021},
  pmid    = {35191835},
  url     = {https://doi.org/10.7554/elife.73021}
}

@article{guo2022-35250543,
  author  = {Guo, S. and Wang, H. and Yin, Y.},
  title   = {{Microglia Polarization From M1 to M2 in Neurodegenerative Diseases}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.815347},
  pmid    = {35250543},
  url     = {https://doi.org/10.3389/fnagi.2022.815347}
}

@article{belsare2022-35082148,
  author  = {Belsare, K. D. and Wu, H. and Mondal, D. and Bond, A. and Castillo, E. and Jin, J. and Jo, H. and Roush, A. E. and others},
  title   = {{Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2022},
  doi     = {10.1073/pnas.2114486119},
  pmid    = {35082148},
  url     = {https://doi.org/10.1073/pnas.2114486119}
}

@article{olufunmilayo2022-35120968,
  author  = {Olufunmilayo, Edward O and Holsinger, R M Damian},
  title   = {{Variant TREM2 Signaling in Alzheimer's Disease}},
  journal = {Journal of molecular biology},
  year    = {2022},
  doi     = {10.1016/j.jmb.2022.167470},
  pmid    = {35120968},
  url     = {https://doi.org/10.1016/j.jmb.2022.167470}
}

@article{jonas2022-35078351,
  author  = {Jonas, Lauren A and Jain, Tanya and Li, Yue-Ming},
  title   = {{Functional insight into LOAD-associated microglial response genes}},
  journal = {Open biology},
  year    = {2022},
  doi     = {10.1098/rsob.210280},
  pmid    = {35078351},
  url     = {https://doi.org/10.1098/rsob.210280}
}

@article{brahadeeswaran2022-35066762,
  author  = {Brahadeeswaran, Subhashini and Sivagurunathan, Narmadhaa and Calivarathan, Latchoumycandane},
  title   = {{Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases}},
  journal = {Molecular neurobiology},
  year    = {2022},
  doi     = {10.1007/s12035-021-02683-5},
  pmid    = {35066762},
  url     = {https://doi.org/10.1007/s12035-021-02683-5}
}

@article{filipello2022-35041990,
  author  = {Filipello, F. and Goldsbury, C. and You, S. F. and Locca, A. and Karch, C. M. and Piccio, L.},
  title   = {{Soluble TREM2: Innocent bystander or active player in neurological diseases?}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105630},
  pmid    = {35041990},
  url     = {https://doi.org/10.1016/j.nbd.2022.105630}
}

@article{reifschneider2022-35019161,
  author  = {Reifschneider, A. and Robinson, S. and van Lengerich, B. and Gnörich, J. and Logan, T. and Heindl, S. and Vogt, M. A. and Weidinger, E. and others},
  title   = {{Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency}},
  journal = {The EMBO journal},
  year    = {2022},
  doi     = {10.15252/embj.2021109108},
  pmid    = {35019161},
  url     = {https://doi.org/10.15252/embj.2021109108}
}

@article{xie2021-35069578,
  author  = {Xie, J. and Van Hoecke, L. and Vandenbroucke, R. E.},
  title   = {{The Impact of Systemic Inflammation on Alzheimer's Disease Pathology}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.796867},
  pmid    = {35069578},
  url     = {https://doi.org/10.3389/fimmu.2021.796867}
}

@article{chappie2022-35059124,
  author  = {Chappie, Thomas A and Abdelmessih, Mario and Ambroise, Claude W and Boehm, Markus and Cai, Mi and Green, Michael and Guilmette, Edward and Steppan, Claire M and others},
  title   = {{Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators}},
  journal = {ACS medicinal chemistry letters},
  year    = {2022},
  doi     = {10.1021/acsmedchemlett.1c00396},
  pmid    = {35059124},
  url     = {https://doi.org/10.1021/acsmedchemlett.1c00396}
}

@article{ruganzu2022-34959070,
  author  = {Ruganzu, J. B. and Peng, X. and He, Y. and Wu, X. and Zheng, Q. and Ding, B. and Lin, C. and Guo, H. and others},
  title   = {{Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease}},
  journal = {Molecular immunology},
  year    = {2022},
  doi     = {10.1016/j.molimm.2021.12.018},
  pmid    = {34959070},
  url     = {https://doi.org/10.1016/j.molimm.2021.12.018}
}

@article{ravichandran2021-34846519,
  author  = {Ravichandran, Kishore Aravind and Heneka, Michael T},
  title   = {{Inflammasome activation in neurodegenerative diseases}},
  journal = {Essays in biochemistry},
  year    = {2021},
  doi     = {10.1042/ebc20210021},
  pmid    = {34846519},
  url     = {https://doi.org/10.1042/ebc20210021}
}

@article{shah2021-34948444,
  author  = {Shah, Akash and Kishore, Uday and Shastri, Abhishek},
  title   = {{Complement System in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222413647},
  pmid    = {34948444},
  url     = {https://doi.org/10.3390/ijms222413647}
}

@article{xie2022-34916658,
  author  = {Xie, M. and Liu, Y. U. and Zhao, S. and Zhang, L. and Bosco, D. B. and Pang, Y. P. and Zhong, J. and Sheth, U. and others},
  title   = {{TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration}},
  journal = {Nature neuroscience},
  year    = {2022},
  doi     = {10.1038/s41593-021-00975-6},
  pmid    = {34916658},
  url     = {https://doi.org/10.1038/s41593-021-00975-6}
}

@article{demiguel2021-34880498,
  author  = {De Miguel, Z. and Khoury, N. and Betley, M. J. and Lehallier, B. and Willoughby, D. and Olsson, N. and Yang, A. C. and Hahn, O. and others},
  title   = {{Exercise plasma boosts memory and dampens brain inflammation via clusterin}},
  journal = {Nature},
  year    = {2021},
  doi     = {10.1038/s41586-021-04183-x},
  pmid    = {34880498},
  url     = {https://doi.org/10.1038/s41586-021-04183-x}
}

@article{koh2021-34884940,
  author  = {Koh, Han Seok and Lee, SangJoon and Lee, Hyo Jin and Min, Jae-Woong and Iwatsubo, Takeshi and Teunissen, Charlotte E and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222313136},
  pmid    = {34884940},
  url     = {https://doi.org/10.3390/ijms222313136}
}

@article{sayed2021-34851693,
  author  = {Sayed, F. A. and Kodama, L. and Fan, L. and Carling, G. K. and Udeochu, J. C. and Le, D. and Li, Q. and Zhou, L. and others},
  title   = {{AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation}},
  journal = {Science translational medicine},
  year    = {2021},
  doi     = {10.1126/scitranslmed.abe3947},
  pmid    = {34851693},
  url     = {https://doi.org/10.1126/scitranslmed.abe3947}
}

@article{lee2021-34965428,
  author  = {Lee, S. H. and Rezzonico, M. G. and Friedman, B. A. and Huntley, M. H. and Meilandt, W. J. and Pandey, S. and Chen, Y. J. and Easton, A. and others},
  title   = {{TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.110158},
  pmid    = {34965428},
  url     = {https://doi.org/10.1016/j.celrep.2021.110158}
}

@article{henn2021-34851663,
  author  = {Henn, D. and Chen, K. and Fehlmann, T. and Trotsyuk, A. A. and Sivaraj, D. and Maan, Z. N. and Bonham, C. A. and Barrera, J. A. and others},
  title   = {{Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2+ macrophages}},
  journal = {Science advances},
  year    = {2021},
  doi     = {10.1126/sciadv.abi4528},
  pmid    = {34851663},
  url     = {https://doi.org/10.1126/sciadv.abi4528}
}

@article{lichtenthaler2022-34689040,
  author  = {Lichtenthaler, S. F. and Tschirner, S. K. and Steiner, H.},
  title   = {{Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2}},
  journal = {Current opinion in neurobiology},
  year    = {2022},
  doi     = {10.1016/j.conb.2021.09.003},
  pmid    = {34689040},
  url     = {https://doi.org/10.1016/j.conb.2021.09.003}
}

@article{xue2022-35847502,
  author  = {Xue, T. and Ji, J. and Sun, Y. and Huang, X. and Cai, Z. and Yang, J. and Guo, W. and Guo, R. and others},
  title   = {{Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury}},
  journal = {Acta pharmaceutica Sinica. B},
  year    = {2022},
  doi     = {10.1016/j.apsb.2021.10.012},
  pmid    = {35847502},
  url     = {https://doi.org/10.1016/j.apsb.2021.10.012}
}

@article{gate2021-34648304,
  author  = {Gate, D. and Tapp, E. and Leventhal, O. and Shahid, M. and Nonninger, T. J. and Yang, A. C. and Strempfl, K. and Unger, M. S. and others},
  title   = {{CD4 + T cells contribute to neurodegeneration in Lewy body dementia}},
  journal = {Science (New York, N.Y.)},
  year    = {2021},
  doi     = {10.1126/science.abf7266},
  pmid    = {34648304},
  url     = {https://doi.org/10.1126/science.abf7266}
}

@article{ghosh2021-34656693,
  author  = {Ghosh, Powsali and Singh, Ravi and Ganeshpurkar, Ankit and Pokle, Ankit Vyankatrao and Singh, Ravi Bhushan and Singh, Sushil Kumar and Kumar, Ashok},
  title   = {{Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts \& roles}},
  journal = {Neurochemistry international},
  year    = {2021},
  doi     = {10.1016/j.neuint.2021.105212},
  pmid    = {34656693},
  url     = {https://doi.org/10.1016/j.neuint.2021.105212}
}

@article{kotredes2021-34707490,
  author  = {Kotredes, K. P. and Oblak, A. and Pandey, R. S. and Lin, P. B. and Garceau, D. and Williams, H. and Uyar, A. and O'Rourke, R. and others},
  title   = {{Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.735524},
  pmid    = {34707490},
  url     = {https://doi.org/10.3389/fnagi.2021.735524}
}

@article{binnewies2021-34686340,
  author  = {Binnewies, M. and Pollack, J. L. and Rudolph, J. and Dash, S. and Abushawish, M. and Lee, T. and Jahchan, N. S. and Canaday, P. and others},
  title   = {{Targeting TREM2 on tumor-associated macrophages enhances immunotherapy}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.109844},
  pmid    = {34686340},
  url     = {https://doi.org/10.1016/j.celrep.2021.109844}
}

@article{kim2021-34638977,
  author  = {Kim, Jieun and Lee, Hyun-Ju and Park, Seon Kyeong and Park, Jin-Hee and Jeong, Ha-Ram and Lee, Soojung and Lee, Heeyong and Seol, Eunyoung and others},
  title   = {{Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms221910637},
  pmid    = {34638977},
  url     = {https://doi.org/10.3390/ijms221910637}
}

@article{okuzono2021-34523252,
  author  = {Okuzono, Yuumi and Sakuma, Hiroyuki and Miyakawa, Shuuichi and Ifuku, Masataka and Lee, Jonghun and Das, Debashree and Banerjee, Antara and Zhao, Yang and others},
  title   = {{Reduced TREM2 activation in microglia of patients with Alzheimer's disease}},
  journal = {FEBS open bio},
  year    = {2021},
  doi     = {10.1002/2211-5463.13300},
  pmid    = {34523252},
  url     = {https://doi.org/10.1002/2211-5463.13300}
}

@article{muzio2021-34630027,
  author  = {Muzio, L. and Viotti, A. and Martino, G.},
  title   = {{Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy}},
  journal = {Frontiers in neuroscience},
  year    = {2021},
  doi     = {10.3389/fnins.2021.742065},
  pmid    = {34630027},
  url     = {https://doi.org/10.3389/fnins.2021.742065}
}

@article{qu2023-34470515,
  author  = {Qu, Wenhui and Li, Ling},
  title   = {{Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2023},
  doi     = {10.1177/10738584211040786},
  pmid    = {34470515},
  url     = {https://doi.org/10.1177/10738584211040786}
}

@article{lier2021-34571885,
  author  = {Lier, J. and Streit, W. J. and Bechmann, I.},
  title   = {{Beyond Activation: Characterizing Microglial Functional Phenotypes}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10092236},
  pmid    = {34571885},
  url     = {https://doi.org/10.3390/cells10092236}
}

@article{joshi2021-34427354,
  author  = {Joshi, Pranav and Riffel, Florian and Satoh, Kanayo and Enomoto, Masahiro and Qamar, Seema and Scheiblich, Hannah and Villacampa, Nàdia and Kumar, Sathish and others},
  title   = {{Differential interaction with TREM2 modulates microglial uptake of modified Aβ species}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.24077},
  pmid    = {34427354},
  url     = {https://doi.org/10.1002/glia.24077}
}

@article{gouna2021-34424266,
  author  = {Gouna, G. and Klose, C. and Bosch-Queralt, M. and Liu, L. and Gokce, O. and Schifferer, M. and Cantuti-Castelvetri, L. and Simons, M.},
  title   = {{TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination}},
  journal = {The Journal of experimental medicine},
  year    = {2021},
  doi     = {10.1084/jem.20210227},
  pmid    = {34424266},
  url     = {https://doi.org/10.1084/jem.20210227}
}

@article{zhang2021-34430820,
  author  = {Zhang, Liansheng and Qian, Yun and Li, Jie and Zhou, Xuan and Xu, He and Yan, Jie and Xiang, Jialing and Yuan, Xiang and others},
  title   = {{BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology}},
  journal = {iScience},
  year    = {2021},
  doi     = {10.1016/j.isci.2021.102942},
  pmid    = {34430820},
  url     = {https://doi.org/10.1016/j.isci.2021.102942}
}

@article{rather2021-34381308,
  author  = {Rather, Mashoque Ahmad and Khan, Andleeb and Alshahrani, Saeed and Rashid, Hina and Qadri, Marwa and Rashid, Summya and Alsaffar, Rana M and Kamal, Mohammad Amjad and others},
  title   = {{Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products}},
  journal = {Mediators of inflammation},
  year    = {2021},
  doi     = {10.1155/2021/9982954},
  pmid    = {34381308},
  url     = {https://doi.org/10.1155/2021/9982954}
}

@article{huang2021-34321623,
  author  = {Huang, Y. and Xu, W. and Zhou, R.},
  title   = {{NLRP3 inflammasome activation and cell death}},
  journal = {Cellular \& molecular immunology},
  year    = {2021},
  doi     = {10.1038/s41423-021-00740-6},
  pmid    = {34321623},
  url     = {https://doi.org/10.1038/s41423-021-00740-6}
}

@article{kulkarni2021-34275100,
  author  = {Kulkarni, Bhargavi and Kumar, Dileep and Cruz-Martins, Natália and Sellamuthu, Satheeshkumar},
  title   = {{Role of TREM2 in Alzheimer's Disease: A Long Road Ahead}},
  journal = {Molecular neurobiology},
  year    = {2021},
  doi     = {10.1007/s12035-021-02477-9},
  pmid    = {34275100},
  url     = {https://doi.org/10.1007/s12035-021-02477-9}
}

@article{xu2021-34187889,
  author  = {Xu, Yin and Propson, Nicholas E and Du, Shuqi and Xiong, Wen and Zheng, Hui},
  title   = {{Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2023418118},
  pmid    = {34187889},
  url     = {https://doi.org/10.1073/pnas.2023418118}
}

@article{schoch2021-34187891,
  author  = {Schoch, K. M. and Ezerskiy, L. A. and Morhaus, M. M. and Bannon, R. N. and Sauerbeck, A. D. and Shabsovich, M. and Jafar-Nejad, P. and Rigo, F. and others},
  title   = {{Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2100356118},
  pmid    = {34187891},
  url     = {https://doi.org/10.1073/pnas.2100356118}
}

@article{sita2021-34209586,
  author  = {Sita, Giulia and Graziosi, Agnese and Hrelia, Patrizia and Morroni, Fabiana},
  title   = {{NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22136984},
  pmid    = {34209586},
  url     = {https://doi.org/10.3390/ijms22136984}
}

@article{mansour2021-34139302,
  author  = {Mansour, Heba M and Fawzy, Hala M and El-Khatib, Aiman S and Khattab, Mahmoud M},
  title   = {{Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer's Disease: Current Perspectives and Challenging Prospects}},
  journal = {Neuroscience},
  year    = {2021},
  doi     = {10.1016/j.neuroscience.2021.06.013},
  pmid    = {34139302},
  url     = {https://doi.org/10.1016/j.neuroscience.2021.06.013}
}

@article{fernandez2021-34177557,
  author  = {Fernández, Dominique and Geisse, Antonia and Bernales, Jose Ignacio and Lira, Alonso and Osorio, Fabiola},
  title   = {{The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.682633},
  pmid    = {34177557},
  url     = {https://doi.org/10.3389/fnagi.2021.682633}
}

@article{lopezrodriguez2021-34080771,
  author  = {Lopez-Rodriguez, Ana Belen and Hennessy, Edel and Murray, Carol L and Nazmi, Arshed and Delaney, Hugh J and Healy, Dáire and Fagan, Steven G and Rooney, Michael and others},
  title   = {{Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12341},
  pmid    = {34080771},
  url     = {https://doi.org/10.1002/alz.12341}
}

@article{grubman2021-34021136,
  author  = {Grubman, A. and Choo, X. Y. and Chew, G. and Ouyang, J. F. and Sun, G. and Croft, N. P. and Rossello, F. J. and Simmons, R. and others},
  title   = {{Transcriptional signature in microglia associated with Aβ plaque phagocytosis}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-23111-1},
  pmid    = {34021136},
  url     = {https://doi.org/10.1038/s41467-021-23111-1}
}

@article{lee2021-33980160,
  author  = {Lee, Hwa-Youn and Lee, Eun-Hee and Yi, Jawoon and Ji, Kon-Young and Kim, Su-Man and Choi, Ha-Rim and Yee, Su-Min and Kang, Hyung-Sik and others},
  title   = {{TREM2 promotes natural killer cell development in CD3-CD122+NK1.1+ pNK cells}},
  journal = {BMC immunology},
  year    = {2021},
  doi     = {10.1186/s12865-021-00420-0},
  pmid    = {33980160},
  url     = {https://doi.org/10.1186/s12865-021-00420-0}
}

@article{shafi2021-33786894,
  author  = {Shafi, Sadat and Singh, Archu and Ibrahim, Abdallah Mohammad and Alhajri, Noora and Izneid, Tareq Abu and Pottoo, Faheem Hyder},
  title   = {{Role of triggering receptor expressed on myeloid cells 2 (TREM2) in neurodegenerative dementias}},
  journal = {The European journal of neuroscience},
  year    = {2021},
  doi     = {10.1111/ejn.15215},
  pmid    = {33786894},
  url     = {https://doi.org/10.1111/ejn.15215}
}

@article{diazlucena2021-33881612,
  author  = {Diaz-Lucena, Daniela and Kruse, Niels and Thüne, Katrin and Schmitz, Matthias and Villar-Piqué, Anna and da Cunha, Jose Eriton Gomes and Hermann, Peter and López-Pérez, Óscar and others},
  title   = {{TREM2 expression in the brain and biological fluids in prion diseases}},
  journal = {Acta neuropathologica},
  year    = {2021},
  doi     = {10.1007/s00401-021-02296-1},
  pmid    = {33881612},
  url     = {https://doi.org/10.1007/s00401-021-02296-1}
}

@article{iizasa2021-33863908,
  author  = {Iizasa, E. and Chuma, Y. and Uematsu, T. and Kubota, M. and Kawaguchi, H. and Umemura, M. and Toyonaga, K. and Kiyohara, H. and others},
  title   = {{TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-22620-3},
  pmid    = {33863908},
  url     = {https://doi.org/10.1038/s41467-021-22620-3}
}

@article{trudler2021-33833060,
  author  = {Trudler, Dorit and Nazor, Kristopher L and Eisele, Yvonne S and Grabauskas, Titas and Dolatabadi, Nima and Parker, James and Sultan, Abdullah and Zhong, Zhenyu and others},
  title   = {{Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2025847118},
  pmid    = {33833060},
  url     = {https://doi.org/10.1073/pnas.2025847118}
}

@article{magno2021-33823896,
  author  = {Magno, Lorenza and Bunney, Tom D and Mead, Emma and Svensson, Fredrik and Bictash, Magda N},
  title   = {{TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00436-5},
  pmid    = {33823896},
  url     = {https://doi.org/10.1186/s13024-021-00436-5}
}

@article{cheng2021-33841415,
  author  = {Cheng, Baoying and Li, Xin and Dai, Kai and Duan, Shengshun and Rong, Zhouyi and Chen, Yingmin and Lü, Liangcheng and Liu, Zhaoji and others},
  title   = {{Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.633796},
  pmid    = {33841415},
  url     = {https://doi.org/10.3389/fimmu.2021.633796}
}

@article{potter2021-33778150,
  author  = {Potter, H. and Woodcock, J. H. and Boyd, T. D. and Coughlan, C. M. and O'Shaughnessy, JR. and Borges, M. T. and Thaker, A. A. and Raj, B. A. and others},
  title   = {{Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12158},
  pmid    = {33778150},
  url     = {https://doi.org/10.1002/trc2.12158}
}

@article{butler2021-33608912,
  author  = {Butler, C. A. and Popescu, A. S. and Kitchener, E. J. A. and Allendorf, D. H. and Puigdellívol, M. and Brown, G. C.},
  title   = {{Microglial phagocytosis of neurons in neurodegeneration, and its regulation}},
  journal = {Journal of neurochemistry},
  year    = {2021},
  doi     = {10.1111/jnc.15327},
  pmid    = {33608912},
  url     = {https://doi.org/10.1111/jnc.15327}
}

@article{holbrook2021-33776778,
  author  = {Holbrook, Jonathan A and Jarosz-Griffiths, Heledd H and Caseley, Emily and Lara-Reyna, Samuel and Poulter, James A and Williams-Gray, Caroline H and Peckham, Daniel and McDermott, Michael F},
  title   = {{Neurodegenerative Disease and the NLRP3 Inflammasome}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.643254},
  pmid    = {33776778},
  url     = {https://doi.org/10.3389/fphar.2021.643254}
}

@article{ferri2020-33768114,
  author  = {Ferri, Evelyn and Rossi, Paolo Dionigi and Geraci, Annalisa and Ciccone, Simona and Cesari, Matteo and Arosio, Beatrice},
  title   = {{The sTREM2 Concentrations in the Blood: A Marker of Neurodegeneration?}},
  journal = {Frontiers in molecular biosciences},
  year    = {2020},
  doi     = {10.3389/fmolb.2020.627931},
  pmid    = {33768114},
  url     = {https://doi.org/10.3389/fmolb.2020.627931}
}

@article{lee2021-33675684,
  author  = {Lee, S. H. and Meilandt, W. J. and Xie, L. and Gandham, V. D. and Ngu, H. and Barck, K. H. and Rezzonico, M. G. and Imperio, J. and others},
  title   = {{Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2021.02.010},
  pmid    = {33675684},
  url     = {https://doi.org/10.1016/j.neuron.2021.02.010}
}

@article{schindler2021-33884297,
  author  = {Schindler, S. E. and Cruchaga, C. and Joseph, A. and McCue, L. and Farias, F. H. G. and Wilkins, C. H. and Deming, Y. and Henson, R. L. and others},
  title   = {{African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants}},
  journal = {Neurology. Genetics},
  year    = {2021},
  doi     = {10.1212/nxg.0000000000000571},
  pmid    = {33884297},
  url     = {https://doi.org/10.1212/nxg.0000000000000571}
}

@article{vanderende2021-33896652,
  author  = {van der Ende, Emma L and Morenas-Rodriguez, Estrella and McMillan, Corey and Grossman, Murray and Irwin, David and Sanchez-Valle, Raquel and Graff, Caroline and Vandenberghe, Rik and others},
  title   = {{CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2021.02.024},
  pmid    = {33896652},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2021.02.024}
}

@article{kim2021-33382892,
  author  = {Kim, Jong-Heon and Afridi, Ruqayya and Han, Jin and Jung, Hyun-Gug and Kim, Seung-Chan and Hwang, Eun Mi and Shim, Hyun Soo and Ryu, Hoon and others},
  title   = {{Gamma subunit of complement component 8 is a neuroinflammation inhibitor}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awaa425},
  pmid    = {33382892},
  url     = {https://doi.org/10.1093/brain/awaa425}
}

@article{sharif2021-33627323,
  author  = {Sharif, O. and Brunner, J. S. and Korosec, A. and Martins, R. and Jais, A. and Snijder, B. and Vogel, A. and Caldera, M. and others},
  title   = {{Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages}},
  journal = {Diabetes},
  year    = {2021},
  doi     = {10.2337/db20-0572},
  pmid    = {33627323},
  url     = {https://doi.org/10.2337/db20-0572}
}

@article{cheng2021-33679809,
  author  = {Cheng, X. and Wang, X. and Nie, K. and Cheng, L. and Zhang, Z. and Hu, Y. and Peng, W.},
  title   = {{Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.646523},
  pmid    = {33679809},
  url     = {https://doi.org/10.3389/fimmu.2021.646523}
}

@article{xue2021-33557250,
  author  = {Xue, Feng and Du, Heng},
  title   = {{TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10020321},
  pmid    = {33557250},
  url     = {https://doi.org/10.3390/cells10020321}
}

@article{reich2020-33613545,
  author  = {Reich, M. and Paris, I. and Ebeling, M. and Dahm, N. and Schweitzer, C. and Reinhardt, D. and Schmucki, R. and Prasad, M. and others},
  title   = {{Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.617860},
  pmid    = {33613545},
  url     = {https://doi.org/10.3389/fimmu.2020.617860}
}

@article{mallach2021-34704019,
  author  = {Mallach, Anna and Gobom, Johan and Zetterberg, Henrik and Hardy, John and Piers, Thomas M and Wray, Selina and Pocock, Jennifer M},
  title   = {{The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles}},
  journal = {Brain communications},
  year    = {2021},
  doi     = {10.1093/braincomms/fcab009},
  pmid    = {34704019},
  url     = {https://doi.org/10.1093/braincomms/fcab009}
}

@article{lei2021-33641782,
  author  = {Lei, Li-Yan and Wang, Rui-Cheng and Pan, Ya-Lei and Yue, Zheng-Gang and Zhou, Rui and Xie, Pei and Tang, Zhi-Shu},
  title   = {{Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway}},
  journal = {Chinese journal of natural medicines},
  year    = {2021},
  doi     = {10.1016/s1875-5364(21)60012-2},
  pmid    = {33641782},
  url     = {https://doi.org/10.1016/s1875-5364(21)60012-2}
}

@article{hou2021-33586673,
  author  = {Hou, J. and Zhang, J. and Cui, P. and Zhou, Y. and Liu, C. and Wu, X. and Ji, Y. and Wang, S. and others},
  title   = {{TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis}},
  journal = {The Journal of clinical investigation},
  year    = {2021},
  doi     = {10.1172/jci135197},
  pmid    = {33586673},
  url     = {https://doi.org/10.1172/jci135197}
}

@article{qin2021-33516818,
  author  = {Qin, Q. and Teng, Z. and Liu, C. and Li, Q. and Yin, Y. and Tang, Y.},
  title   = {{TREM2, microglia, and Alzheimer's disease}},
  journal = {Mechanisms of ageing and development},
  year    = {2021},
  doi     = {10.1016/j.mad.2021.111438},
  pmid    = {33516818},
  url     = {https://doi.org/10.1016/j.mad.2021.111438}
}

@article{sandhu2021-33499208,
  author  = {Sandhu, Jagdeep K and Kulka, Marianna},
  title   = {{Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22031093},
  pmid    = {33499208},
  url     = {https://doi.org/10.3390/ijms22031093}
}

@article{minhas2021-33473210,
  author  = {Minhas, P. S. and Latif-Hernandez, A. and McReynolds, M. R. and Durairaj, A. S. and Wang, Q. and Rubin, A. and Joshi, A. U. and He, J. Q. and others},
  title   = {{Restoring metabolism of myeloid cells reverses cognitive decline in ageing}},
  journal = {Nature},
  year    = {2021},
  doi     = {10.1038/s41586-020-03160-0},
  pmid    = {33473210},
  url     = {https://doi.org/10.1038/s41586-020-03160-0}
}

@article{akhter2021-33461764,
  author  = {Akhter, R. and Shao, Y. and Formica, S. and Khrestian, M. and Bekris, L. M.},
  title   = {{TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells}},
  journal = {Molecular immunology},
  year    = {2021},
  doi     = {10.1016/j.molimm.2020.12.035},
  pmid    = {33461764},
  url     = {https://doi.org/10.1016/j.molimm.2020.12.035}
}

@article{fassler2021-33422057,
  author  = {Fassler, M. and Rappaport, M. S. and Cuño, C. B. and George, J.},
  title   = {{Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-020-01980-5},
  pmid    = {33422057},
  url     = {https://doi.org/10.1186/s12974-020-01980-5}
}

@article{lee2021-34668411,
  author  = {Lee, SangJoon and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Innate Immunity and Cell Death in Alzheimer's Disease}},
  journal = {ASN neuro},
  year    = {2021},
  doi     = {10.1177/17590914211051908},
  pmid    = {34668411},
  url     = {https://doi.org/10.1177/17590914211051908}
}

@article{liang2021-34749609,
  author  = {Liang, Xinyan and Wu, Haijian and Colt, Mark and Guo, Xinying and Pluimer, Brock and Zeng, Jianxiong and Dong, Shupeng and Zhao, Zhen},
  title   = {{Microglia and its Genetics in Alzheimer's Disease}},
  journal = {Current Alzheimer research},
  year    = {2021},
  doi     = {10.2174/1567205018666211105140732},
  pmid    = {34749609},
  url     = {https://doi.org/10.2174/1567205018666211105140732}
}

@article{toscano2021-34530705,
  author  = {Toscano, Eliana C de Brito and Rocha, Natalia P and Lopes, Beatriz N A and Suemoto, Claudia K and Teixeira, Antonio L},
  title   = {{Neuroinflammation in Alzheimer's Disease: Focus on NLRP1 and NLRP3 Inflammasomes}},
  journal = {Current protein \& peptide science},
  year    = {2021},
  doi     = {10.2174/1389203722666210916141436},
  pmid    = {34530705},
  url     = {https://doi.org/10.2174/1389203722666210916141436}
}

@article{vanzeller2021-34366341,
  author  = {Van Zeller, Mariana and Dias, Diogo and Sebastião, Ana M and Valente, Cláudia A},
  title   = {{NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210268},
  pmid    = {34366341},
  url     = {https://doi.org/10.3233/jad-210268}
}

@article{ellwanger2021-33446504,
  author  = {Ellwanger, D. C. and Wang, S. and Brioschi, S. and Shao, Z. and Green, L. and Case, R. and Yoo, D. and Weishuhn, D. and others},
  title   = {{Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2017742118},
  pmid    = {33446504},
  url     = {https://doi.org/10.1073/pnas.2017742118}
}

@article{golzarisorkheh2021-34569958,
  author  = {Golzari-Sorkheh, Mahdieh and Brown, Carla E and Weaver, Donald F and Reed, Mark A},
  title   = {{The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210660},
  pmid    = {34569958},
  url     = {https://doi.org/10.3233/jad-210660}
}

@article{vilalta2021-33823153,
  author  = {Vilalta, A. and Zhou, Y. and Sevalle, J. and Griffin, J. K. and Satoh, K. and Allendorf, D. H. and De, S. and Puigdellívol, M. and others},
  title   = {{Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation}},
  journal = {The Journal of biological chemistry},
  year    = {2021},
  doi     = {10.1016/j.jbc.2021.100631},
  pmid    = {33823153},
  url     = {https://doi.org/10.1016/j.jbc.2021.100631}
}

@article{weng2021-33486152,
  author  = {Weng, Y. and Wang, H. and Li, L. and Feng, Y. and Xu, S. and Wang, Z.},
  title   = {{Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment}},
  journal = {Redox biology},
  year    = {2021},
  doi     = {10.1016/j.redox.2020.101849},
  pmid    = {33486152},
  url     = {https://doi.org/10.1016/j.redox.2020.101849}
}

@article{delaney2021-33350588,
  author  = {Delaney, Conor and Farrell, Michael and Doherty, Colin P and Brennan, Kiva and O'Keeffe, Eoin and Greene, Chris and Byrne, Kieva and Kelly, Eoin and others},
  title   = {{Attenuated CSF-1R signalling drives cerebrovascular pathology}},
  journal = {EMBO molecular medicine},
  year    = {2021},
  doi     = {10.15252/emmm.202012889},
  pmid    = {33350588},
  url     = {https://doi.org/10.15252/emmm.202012889}
}

@article{ibach2021-33314333,
  author  = {Ibach, Melanie and Mathews, Mona and Linnartz-Gerlach, Bettina and Theil, Sandra and Kumar, Sathish and Feederle, Regina and Brüstle, Oliver and Neumann, Harald and others},
  title   = {{A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.23953},
  pmid    = {33314333},
  url     = {https://doi.org/10.1002/glia.23953}
}

@article{audrain2021-33314529,
  author  = {Audrain, M. and Haure-Mirande, J. V. and Mleczko, J. and Wang, M. and Griffin, J. K. and St George-Hyslop, P. H. and Fraser, P. and Zhang, B. and others},
  title   = {{Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12256},
  pmid    = {33314529},
  url     = {https://doi.org/10.1002/alz.12256}
}

@article{sun2020-33297569,
  author  = {Sun, H. and Feng, J. and Tang, L.},
  title   = {{Function of TREM1 and TREM2 in Liver-Related Diseases}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9122626},
  pmid    = {33297569},
  url     = {https://doi.org/10.3390/cells9122626}
}

@article{kwon2020-33239064,
  author  = {Kwon, H. S. and Koh, S. H.},
  title   = {{Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes}},
  journal = {Translational neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s40035-020-00221-2},
  pmid    = {33239064},
  url     = {https://doi.org/10.1186/s40035-020-00221-2}
}

@article{giorgi2020-33207731,
  author  = {Giorgi, Filippo Sean and Biagioni, Francesca and Galgani, Alessandro and Pavese, Nicola and Lazzeri, Gloria and Fornai, Francesco},
  title   = {{Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21228630},
  pmid    = {33207731},
  url     = {https://doi.org/10.3390/ijms21228630}
}

@article{hallroberts2020-33198789,
  author  = {Hall-Roberts, H. and Agarwal, D. and Obst, J. and Smith, T. B. and Monzón-Sandoval, J. and Di Daniel, E. and Webber, C. and James, W. S. and others},
  title   = {{TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00709-z},
  pmid    = {33198789},
  url     = {https://doi.org/10.1186/s13195-020-00709-z}
}

@article{milner2021-33181351,
  author  = {Milner, Mark T and Maddugoda, Madhavi and Götz, Jürgen and Burgener, Sabrina S and Schroder, Kate},
  title   = {{The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease}},
  journal = {Current opinion in immunology},
  year    = {2021},
  doi     = {10.1016/j.coi.2020.10.011},
  pmid    = {33181351},
  url     = {https://doi.org/10.1016/j.coi.2020.10.011}
}

@article{qu2020-33139402,
  author  = {Qu, W. and Li, L.},
  title   = {{Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.2193-20.2020},
  pmid    = {33139402},
  url     = {https://doi.org/10.1523/jneurosci.2193-20.2020}
}

@article{liu2020-32959884,
  author  = {Liu, W. and Taso, O. and Wang, R. and Bayram, S. and Graham, A. C. and Garcia-Reitboeck, P. and Mallach, A. and Andrews, W. D. and others},
  title   = {{Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions}},
  journal = {Human molecular genetics},
  year    = {2020},
  doi     = {10.1093/hmg/ddaa209},
  pmid    = {32959884},
  url     = {https://doi.org/10.1093/hmg/ddaa209}
}

@article{elsahar2020-33125461,
  author  = {El-Sahar, Ayman E. and Shiha, Nesma A. and El Sayed, Nesrine S. and Ahmed, Lamiaa A.},
  title   = {{Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways}},
  journal = {The International Journal of Neuropsychopharmacology},
  year    = {2020},
  doi     = {10.1093/ijnp/pyaa078},
  pmid    = {33125461},
  url     = {https://doi.org/10.1093/ijnp/pyaa078}
}

@article{jadhav2020-33115519,
  author  = {Jadhav, V. S. and Lin, P. B. C. and Pennington, T. and Di Prisco, G. V. and Jannu, A. J. and Xu, G. and Moutinho, M. and Zhang, J. and others},
  title   = {{Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00409-0},
  pmid    = {33115519},
  url     = {https://doi.org/10.1186/s13024-020-00409-0}
}

@article{podlesnydrabiniok2020-33127097,
  author  = {Podleśny-Drabiniok, A. and Marcora, E. and Goate, A. M.},
  title   = {{Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics}},
  journal = {Trends in neurosciences},
  year    = {2020},
  doi     = {10.1016/j.tins.2020.10.002},
  pmid    = {33127097},
  url     = {https://doi.org/10.1016/j.tins.2020.10.002}
}

@article{mcquade2020-33097708,
  author  = {McQuade, A. and Kang, Y. J. and Hasselmann, J. and Jairaman, A. and Sotelo, A. and Coburn, M. and Shabestari, S. K. and Chadarevian, J. P. and others},
  title   = {{Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-19227-5},
  pmid    = {33097708},
  url     = {https://doi.org/10.1038/s41467-020-19227-5}
}

@article{wang2020-33065553,
  author  = {Wang, Y. and Lin, Y. and Wang, L. and Zhan, H. and Luo, X. and Zeng, Y. and Wu, W. and Zhang, X. and others},
  title   = {{TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice}},
  journal = {Aging},
  year    = {2020},
  doi     = {10.18632/aging.104104},
  pmid    = {33065553},
  url     = {https://doi.org/10.18632/aging.104104}
}

@article{ruganzu2021-33065077,
  author  = {Ruganzu, J. B. and Zheng, Q. and Wu, X. and He, Y. and Peng, X. and Jin, H. and Zhou, J. and Ma, R. and others},
  title   = {{TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway}},
  journal = {Experimental neurology},
  year    = {2021},
  doi     = {10.1016/j.expneurol.2020.113506},
  pmid    = {33065077},
  url     = {https://doi.org/10.1016/j.expneurol.2020.113506}
}

@article{xiong2020-33033253,
  author  = {Xiong, D. and Wang, Y. and You, M.},
  title   = {{A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-18546-x},
  pmid    = {33033253},
  url     = {https://doi.org/10.1038/s41467-020-18546-x}
}

@article{kober2020-33090700,
  author  = {Kober, D. L. and Stuchell-Brereton, M. D. and Kluender, C. E. and Dean, H. B. and Strickland, M. R. and Steinberg, D. F. and Nelson, S. S. and Baban, B. and others},
  title   = {{Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12194},
  pmid    = {33090700},
  url     = {https://doi.org/10.1002/alz.12194}
}

@article{franzmeier2020-33032659,
  author  = {Franzmeier, N. and Suárez-Calvet, M. and Frontzkowski, L. and Moore, A. and Hohman, T. J. and Morenas-Rodriguez, E. and Nuscher, B. and Shaw, L. and others},
  title   = {{Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00407-2},
  pmid    = {33032659},
  url     = {https://doi.org/10.1186/s13024-020-00407-2}
}

@article{olsen2020-33062201,
  author  = {Olsen, Ingar and Singhrao, Sim K},
  title   = {{Interaction between genetic factors, Porphyromonas gingivalis and microglia to promote Alzheimer's disease}},
  journal = {Journal of oral microbiology},
  year    = {2020},
  doi     = {10.1080/20002297.2020.1820834},
  pmid    = {33062201},
  url     = {https://doi.org/10.1080/20002297.2020.1820834}
}

@article{wang2020-32579671,
  author  = {Wang, S. and Mustafa, M. and Yuede, C. M. and Salazar, S. V. and Kong, P. and Long, H. and Ward, M. and Siddiqui, O. and others},
  title   = {{Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model}},
  journal = {The Journal of experimental medicine},
  year    = {2020},
  doi     = {10.1084/jem.20200785},
  pmid    = {32579671},
  url     = {https://doi.org/10.1084/jem.20200785}
}

@article{gratuze2020-32544086,
  author  = {Gratuze, M. and Leyns, C. E. and Sauerbeck, A. D. and St-Pierre, M. K. and Xiong, M. and Kim, N. and Serrano, JR. and MÈ, Tremblay and others},
  title   = {{Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration}},
  journal = {The Journal of clinical investigation},
  year    = {2020},
  doi     = {10.1172/jci138179},
  pmid    = {32544086},
  url     = {https://doi.org/10.1172/jci138179}
}

@article{nguyen2020-32840654,
  author  = {Nguyen, A. T. and Wang, K. and Hu, G. and Wang, X. and Miao, Z. and Azevedo, J. A. and Suh, E. and Van Deerlin, V. M. and others},
  title   = {{APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02200-3},
  pmid    = {32840654},
  url     = {https://doi.org/10.1007/s00401-020-02200-3}
}

@article{price2020-32795308,
  author  = {Price, B. R. and Sudduth, T. L. and Weekman, E. M. and Johnson, S. and Hawthorne, D. and Woolums, A. and Wilcock, D. M.},
  title   = {{Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01915-0},
  pmid    = {32795308},
  url     = {https://doi.org/10.1186/s12974-020-01915-0}
}

@article{simpson2020-32823544,
  author  = {Simpson, D. S. A. and Oliver, P. L.},
  title   = {{ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2020},
  doi     = {10.3390/antiox9080743},
  pmid    = {32823544},
  url     = {https://doi.org/10.3390/antiox9080743}
}

@article{katzenelenbogen2020-32783915,
  author  = {Katzenelenbogen, Y. and Sheban, F. and Yalin, A. and Yofe, I. and Svetlichnyy, D. and Jaitin, D. A. and Bornstein, C. and Moshe, A. and others},
  title   = {{Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.06.032},
  pmid    = {32783915},
  url     = {https://doi.org/10.1016/j.cell.2020.06.032}
}

@article{molgora2020-32783918,
  author  = {Molgora, M. and Esaulova, E. and Vermi, W. and Hou, J. and Chen, Y. and Luo, J. and Brioschi, S. and Bugatti, M. and others},
  title   = {{TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.07.013},
  pmid    = {32783918},
  url     = {https://doi.org/10.1016/j.cell.2020.07.013}
}

@article{cignarella2020-32772264,
  author  = {Cignarella, F. and Filipello, F. and Bollman, B. and Cantoni, C. and Locca, A. and Mikesell, R. and Manis, M. and Ibrahim, A. and others},
  title   = {{TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02193-z},
  pmid    = {32772264},
  url     = {https://doi.org/10.1007/s00401-020-02193-z}
}

@article{taylor2020-32711525,
  author  = {Taylor, X. and Cisternas, P. and You, Y. and Xiang, S. and Marambio, Y. and Zhang, J. and Vidal, R. and others},
  title   = {{A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01900-7},
  pmid    = {32711525},
  url     = {https://doi.org/10.1186/s12974-020-01900-7}
}

@article{guan2020-32792920,
  author  = {Guan, Yadi and Han, Fang},
  title   = {{Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases}},
  journal = {Frontiers in integrative neuroscience},
  year    = {2020},
  doi     = {10.3389/fnint.2020.00037},
  pmid    = {32792920},
  url     = {https://doi.org/10.3389/fnint.2020.00037}
}

@article{edison2020-32739010,
  author  = {Edison, Paul},
  title   = {{Neuroinflammation, microglial activation, and glucose metabolism in neurodegenerative diseases}},
  journal = {International review of neurobiology},
  year    = {2020},
  doi     = {10.1016/bs.irn.2020.03.017},
  pmid    = {32739010},
  url     = {https://doi.org/10.1016/bs.irn.2020.03.017}
}

@article{fitz2020-32703241,
  author  = {Fitz, N. F. and Wolfe, C. M. and Playso, B. E. and Biedrzycki, R. J. and Lu, Y. and Nam, K. N. and Lefterov, I. and Koldamova, R.},
  title   = {{Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00394-4},
  pmid    = {32703241},
  url     = {https://doi.org/10.1186/s13024-020-00394-4}
}

@article{yang2020-32635934,
  author  = {Yang, J. and Fu, Z. and Zhang, X. and Xiong, M. and Meng, L. and Zhang, Z.},
  title   = {{TREM2 ectodomain and its soluble form in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01878-2},
  pmid    = {32635934},
  url     = {https://doi.org/10.1186/s12974-020-01878-2}
}

@article{meszaros2020-32635451,
  author  = {Mészáros, Ádám and Molnár, Kinga and Nógrádi, Bernát and Hernádi, Zsófia and Nyúl-Tóth, Ádám and Wilhelm, Imola and Krizbai, István A},
  title   = {{Neurovascular Inflammaging in Health and Disease}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9071614},
  pmid    = {32635451},
  url     = {https://doi.org/10.3390/cells9071614}
}

@article{ren2020-32579116,
  author  = {Ren, S. and Yao, W. and Tambini, M. D. and Yin, T. and Norris, K. A. and D'Adamio, L.},
  title   = {{Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels}},
  journal = {eLife},
  year    = {2020},
  doi     = {10.7554/elife.57513},
  pmid    = {32579116},
  url     = {https://doi.org/10.7554/elife.57513}
}

@article{fusco2020-32545788,
  author  = {Fusco, R. and Siracusa, R. and Genovese, T. and Cuzzocrea, S. and Di Paola, R.},
  title   = {{Focus on the Role of NLRP3 Inflammasome in Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21124223},
  pmid    = {32545788},
  url     = {https://doi.org/10.3390/ijms21124223}
}

@article{wang2020-32617097,
  author  = {Wang, Qian and Yang, Weixia and Zhang, Jingmei and Zhao, Yueran and Xu, Yuzhen},
  title   = {{TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia}},
  journal = {Neural plasticity},
  year    = {2020},
  doi     = {10.1155/2020/8834275},
  pmid    = {32617097},
  url     = {https://doi.org/10.1155/2020/8834275}
}

@article{qin2020-32412103,
  author  = {Qin, Zhangjin and Gu, Min and Zhou, Jian and Zhang, Wenbo and Zhao, Nan and Lü, Yang and Yu, Weihua},
  title   = {{Triggering receptor expressed on myeloid cells 2 activation downregulates toll-like receptor 4 expression and ameliorates cognitive impairment in the Aβ1-42 -induced Alzheimer's disease mouse model}},
  journal = {Synapse (New York, N.Y.)},
  year    = {2020},
  doi     = {10.1002/syn.22161},
  pmid    = {32412103},
  url     = {https://doi.org/10.1002/syn.22161}
}

@article{andreone2020-32514138,
  author  = {Andreone, B. J. and Przybyla, L. and Llapashtica, C. and Rana, A. and Davis, S. S. and van Lengerich, B. and Lin, K. and Shi, J. and others},
  title   = {{Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia}},
  journal = {Nature neuroscience},
  year    = {2020},
  doi     = {10.1038/s41593-020-0650-6},
  pmid    = {32514138},
  url     = {https://doi.org/10.1038/s41593-020-0650-6}
}

@article{deczkowska2020-32531244,
  author  = {Deczkowska, A. and Weiner, A. and Amit, I.},
  title   = {{The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.05.003},
  pmid    = {32531244},
  url     = {https://doi.org/10.1016/j.cell.2020.05.003}
}

@article{chen2020-32466767,
  author  = {Chen, S. and Peng, J. and Sherchan, P. and Ma, Y. and Xiang, S. and Yan, F. and Zhao, H. and Jiang, Y. and others},
  title   = {{TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01853-x},
  pmid    = {32466767},
  url     = {https://doi.org/10.1186/s12974-020-01853-x}
}

@article{wu2022-35224156,
  author  = {Wu, M. and Liao, M. and Huang, R. and Chen, C. and Tian, T. and Wang, H. and Li, J. and others},
  title   = {{Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia}},
  journal = {Genes \& diseases},
  year    = {2022},
  doi     = {10.1016/j.gendis.2020.05.005},
  pmid    = {35224156},
  url     = {https://doi.org/10.1016/j.gendis.2020.05.005}
}

@article{zhu2020-32401783,
  author  = {Zhu, Z. and Zhang, X. and Dong, W. and Wang, X. and He, S. and Zhang, H. and Wei, R. and others},
  title   = {{TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling}},
  journal = {PLoS pathogens},
  year    = {2020},
  doi     = {10.1371/journal.ppat.1008543},
  pmid    = {32401783},
  url     = {https://doi.org/10.1371/journal.ppat.1008543}
}

@article{yang2020-32391019,
  author  = {Yang, Junling and Wise, Leslie and Fukuchi, Ken-Ichiro},
  title   = {{TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.00724},
  pmid    = {32391019},
  url     = {https://doi.org/10.3389/fimmu.2020.00724}
}

@article{ma2020-32276587,
  author  = {Ma, L. Z. and Tan, L. and Bi, Y. L. and Shen, X. N. and Xu, W. and Ma, Y. H. and Li, H. Q. and Dong, Q. and others},
  title   = {{Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00374-8},
  pmid    = {32276587},
  url     = {https://doi.org/10.1186/s13024-020-00374-8}
}

@article{berner2020-32237095,
  author  = {Berner, Dennis Kristopher and Wessolowski, Luisa and Armbrust, Fred and Schneppenheim, Janna and Schlepckow, Kai and Koudelka, Tomas and Scharfenberg, Franka and Lucius, Ralph and others},
  title   = {{Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2020},
  doi     = {10.1096/fj.201902183r},
  pmid    = {32237095},
  url     = {https://doi.org/10.1096/fj.201902183r}
}

@article{kleineidam2020-32166339,
  author  = {Kleineidam, L. and Chouraki, V. and Próchnicki, T. and van der Lee, S. J. and Madrid-Márquez, L. and Wagner-Thelen, H. and Karaca, I. and Weinhold, L. and others},
  title   = {{PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02138-6},
  pmid    = {32166339},
  url     = {https://doi.org/10.1007/s00401-020-02138-6}
}

@article{schlepckow2020-32154671,
  author  = {Schlepckow, K. and Monroe, K. M. and Kleinberger, G. and Cantuti-Castelvetri, L. and Parhizkar, S. and Xia, D. and Willem, M. and Werner, G. and others},
  title   = {{Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region}},
  journal = {EMBO molecular medicine},
  year    = {2020},
  doi     = {10.15252/emmm.201911227},
  pmid    = {32154671},
  url     = {https://doi.org/10.15252/emmm.201911227}
}

@article{wilson2020-32065223,
  author  = {Wilson, E. N. and Swarovski, M. S. and Linortner, P. and Shahid, M. and Zuckerman, A. J. and Wang, Q. and Channappa, D. and Minhas, P. S. and others},
  title   = {{Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awaa021},
  pmid    = {32065223},
  url     = {https://doi.org/10.1093/brain/awaa021}
}

@article{meilandt2020-31980586,
  author  = {Meilandt, W. J. and Ngu, H. and Gogineni, A. and Lalehzadeh, G. and Lee, S. H. and Srinivasan, K. and Imperio, J. and Wu, T. and others},
  title   = {{Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.1871-19.2019},
  pmid    = {31980586},
  url     = {https://doi.org/10.1523/jneurosci.1871-19.2019}
}

@article{weber2020-31959733,
  author  = {Weber, G. E. and Koenig, K. A. and Khrestian, M. and Shao, Y. and Tuason, E. D. and Gramm, M. and Lal, D. and Leverenz, J. B. and others},
  title   = {{An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2020},
  doi     = {10.4049/jimmunol.1901166},
  pmid    = {31959733},
  url     = {https://doi.org/10.4049/jimmunol.1901166}
}

@article{zhou2020-31932797,
  author  = {Zhou, Y. and Song, W. M. and Andhey, P. S. and Swain, A. and Levy, T. and Miller, K. R. and Poliani, P. L. and Cominelli, M. and others},
  title   = {{Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2020},
  doi     = {10.1038/s41591-019-0695-9},
  pmid    = {31932797},
  url     = {https://doi.org/10.1038/s41591-019-0695-9}
}

@article{madore2020-31924476,
  author  = {Madore, C. and Yin, Z. and Leibowitz, J. and Butovsky, O.},
  title   = {{Microglia, Lifestyle Stress, and Neurodegeneration}},
  journal = {Immunity},
  year    = {2020},
  doi     = {10.1016/j.immuni.2019.12.003},
  pmid    = {31924476},
  url     = {https://doi.org/10.1016/j.immuni.2019.12.003}
}

@article{nugent2020-31902528,
  author  = {Nugent, A. A. and Lin, K. and van Lengerich, B. and Lianoglou, S. and Przybyla, L. and Davis, S. S. and Llapashtica, C. and Wang, J. and others},
  title   = {{TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2019.12.007},
  pmid    = {31902528},
  url     = {https://doi.org/10.1016/j.neuron.2019.12.007}
}

@article{fung2020-32741831,
  author  = {Fung, Susan and Smith, Carole L and Prater, Katherine E and Case, Amanda and Green, Kevin and Osnis, Leah and Winston, Chloe and Kinoshita, Yoshito and others},
  title   = {{Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200492},
  pmid    = {32741831},
  url     = {https://doi.org/10.3233/jad-200492}
}

@article{babicleko2020-32390629,
  author  = {Babić Leko, M. and Nikolac Perković, M. and Klepac, N. and DŠ, Štrac and Borovečki, F. and Pivac, N. and Hof, P. R. and Šimić, G.},
  title   = {{IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer's Disease Pathology}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200056},
  pmid    = {32390629},
  url     = {https://doi.org/10.3233/jad-200056}
}

@article{rauchmann2020-31958095,
  author  = {Rauchmann, B. S. and Sadlon, A. and Perneczky, R. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-191120},
  pmid    = {31958095},
  url     = {https://doi.org/10.3233/jad-191120}
}

@article{piers2020-31907987,
  author  = {Piers, T. M. and Cosker, K. and Mallach, A. and Johnson, G. T. and Guerreiro, R. and Hardy, J. and Pocock, J. M.},
  title   = {{A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2020},
  doi     = {10.1096/fj.201902447r},
  pmid    = {31907987},
  url     = {https://doi.org/10.1096/fj.201902447r}
}

@article{geirsdottir2019-31835035,
  author  = {Geirsdottir, L. and David, E. and Keren-Shaul, H. and Weiner, A. and Bohlen, S. C. and Neuber, J. and Balic, A. and Giladi, A. and others},
  title   = {{Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program}},
  journal = {Cell},
  year    = {2019},
  doi     = {10.1016/j.cell.2019.11.010},
  pmid    = {31835035},
  url     = {https://doi.org/10.1016/j.cell.2019.11.010}
}

@article{ho2020-31786775,
  author  = {Ho, Wen-Chien and Hsu, Chia-Chi and Huang, Hui-Ju and Wang, Hsiang-Tsui and Lin, Anya Maan-Yuh},
  title   = {{Anti-inflammatory Effect of AZD6244 on Acrolein-Induced Neuroinflammation}},
  journal = {Molecular neurobiology},
  year    = {2020},
  doi     = {10.1007/s12035-019-01758-8},
  pmid    = {31786775},
  url     = {https://doi.org/10.1007/s12035-019-01758-8}
}

@article{xue2020-31836271,
  author  = {Xue, D. and Tabib, T. and Morse, C. and Lafyatis, R.},
  title   = {{Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors}},
  journal = {Journal of dermatological science},
  year    = {2020},
  doi     = {10.1016/j.jdermsci.2019.11.012},
  pmid    = {31836271},
  url     = {https://doi.org/10.1016/j.jdermsci.2019.11.012}
}

@article{zhong2019-32038221,
  author  = {Zhong, Li and Chen, Xiao-Fen},
  title   = {{The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2019},
  doi     = {10.3389/fnagi.2019.00328},
  pmid    = {32038221},
  url     = {https://doi.org/10.3389/fnagi.2019.00328}
}

@article{dinet2019-31780883,
  author  = {Dinet, Virginie and Petry, Klaus G and Badaut, Jerome},
  title   = {{Brain-Immune Interactions and Neuroinflammation After Traumatic Brain Injury}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.01178},
  pmid    = {31780883},
  url     = {https://doi.org/10.3389/fnins.2019.01178}
}

@article{venegas2019-31702392,
  author  = {Venegas, Carmen and Heneka, Michael T},
  title   = {{Inflammasome-mediated innate immunity in Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900439},
  pmid    = {31702392},
  url     = {https://doi.org/10.1096/fj.201900439}
}

@article{yao2019-31649511,
  author  = {Yao, H. and Coppola, K. and Schweig, J. E. and Crawford, F. and Mullan, M. and Paris, D.},
  title   = {{Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2019},
  doi     = {10.3389/fncel.2019.00457},
  pmid    = {31649511},
  url     = {https://doi.org/10.3389/fncel.2019.00457}
}

@article{shi2019-31601677,
  author  = {Shi, Yang and Manis, Melissa and Long, Justin M. and Wang, Kairuo and Sullivan, Patrick M. and Serrano, Javier Remolina and Hoyle, Rosa and Holtzman, David M.},
  title   = {{Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model}},
  journal = {The Journal of Experimental Medicine},
  year    = {2019},
  doi     = {10.1084/jem.20190980},
  pmid    = {31601677},
  url     = {https://doi.org/10.1084/jem.20190980}
}

@article{mancuso2019-31504240,
  author  = {Mancuso, R. and Fryatt, G. and Cleal, M. and Obst, J. and Pipi, E. and Monzón-Sandoval, J. and Ribe, E. and Winchester, L. and others},
  title   = {{CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice}},
  journal = {Brain : a journal of neurology},
  year    = {2019},
  doi     = {10.1093/brain/awz241},
  pmid    = {31504240},
  url     = {https://doi.org/10.1093/brain/awz241}
}

@article{pereira2019-31577960,
  author  = {Pereira, Claudia F and Santos, Armanda E and Moreira, Paula I and Pereira, Ana Catarina and Sousa, Fabio J and Cardoso, Sandra M and Cruz, M Teresa},
  title   = {{Is Alzheimer's disease an inflammasomopathy?}},
  journal = {Ageing research reviews},
  year    = {2019},
  doi     = {10.1016/j.arr.2019.100966},
  pmid    = {31577960},
  url     = {https://doi.org/10.1016/j.arr.2019.100966}
}

@article{karanfilian2020-31727362,
  author  = {Karanfilian, Lucine and Tosto, Maria Grazia and Malki, Karim},
  title   = {{The role of TREM2 in Alzheimer's disease; evidence from transgenic mouse models}},
  journal = {Neurobiology of aging},
  year    = {2020},
  doi     = {10.1016/j.neurobiolaging.2019.09.004},
  pmid    = {31727362},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2019.09.004}
}

@article{guzmanmartinez2019-31572186,
  author  = {Guzman-Martinez, L. and Maccioni, R. B. and Andrade, V. and Navarrete, L. P. and Pastor, M. G. and Ramos-Escobar, N.},
  title   = {{Neuroinflammation as a Common Feature of Neurodegenerative Disorders}},
  journal = {Frontiers in pharmacology},
  year    = {2019},
  doi     = {10.3389/fphar.2019.01008},
  pmid    = {31572186},
  url     = {https://doi.org/10.3389/fphar.2019.01008}
}

@article{liu2019-31477129,
  author  = {Liu, C. and Li, P. and Li, H. and Wang, S. and Ding, L. and Wang, H. and Ye, H. and Jin, Y. and others},
  title   = {{TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding}},
  journal = {Journal of translational medicine},
  year    = {2019},
  doi     = {10.1186/s12967-019-2050-9},
  pmid    = {31477129},
  url     = {https://doi.org/10.1186/s12967-019-2050-9}
}

@article{spangenberg2019-31434879,
  author  = {Spangenberg, E. and Severson, P. L. and Hohsfield, L. A. and Crapser, J. and Zhang, J. and Burton, E. A. and Zhang, Y. and Spevak, W. and others},
  title   = {{Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model}},
  journal = {Nature communications},
  year    = {2019},
  doi     = {10.1038/s41467-019-11674-z},
  pmid    = {31434879},
  url     = {https://doi.org/10.1038/s41467-019-11674-z}
}

@article{ewers2019-31462511,
  author  = {Ewers, M. and Franzmeier, N. and Suárez-Calvet, M. and Morenas-Rodriguez, E. and Caballero, M. A. A. and Kleinberger, G. and Piccio, L. and Cruchaga, C. and others},
  title   = {{Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease}},
  journal = {Science translational medicine},
  year    = {2019},
  doi     = {10.1126/scitranslmed.aav6221},
  pmid    = {31462511},
  url     = {https://doi.org/10.1126/scitranslmed.aav6221}
}

@article{deming2019-31413141,
  author  = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others},
  title   = {{The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk}},
  journal = {Science translational medicine},
  year    = {2019},
  doi     = {10.1126/scitranslmed.aau2291},
  pmid    = {31413141},
  url     = {https://doi.org/10.1126/scitranslmed.aau2291}
}

@article{guo2019-31370707,
  author  = {Guo, Y. and Wei, X. and Yan, H. and Qin, Y. and Yan, S. and Liu, J. and Zhao, Y. and Jiang, F. and others},
  title   = {{TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900992r},
  pmid    = {31370707},
  url     = {https://doi.org/10.1096/fj.201900992r}
}

@article{prokop2019-31350575,
  author  = {Prokop, S. and Miller, K. R. and Labra, SR. and Pitkin, R. M. and Hoxha, K. and Narasimhan, S. and Changolkar, L. and Rosenbloom, A. and others},
  title   = {{Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02048-2},
  pmid    = {31350575},
  url     = {https://doi.org/10.1007/s00401-019-02048-2}
}

@article{gervois2019-31379859,
  author  = {Gervois, P. and Lambrichts, I.},
  title   = {{The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke}},
  journal = {Frontiers in immunology},
  year    = {2019},
  doi     = {10.3389/fimmu.2019.01668},
  pmid    = {31379859},
  url     = {https://doi.org/10.3389/fimmu.2019.01668}
}

@article{griciuc2019-31301936,
  author  = {Griciuc, A. and Patel, S. and Federico, A. N. and Choi, S. H. and Innes, B. J. and Oram, M. K. and Cereghetti, G. and McGinty, D. and others},
  title   = {{TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2019},
  doi     = {10.1016/j.neuron.2019.06.010},
  pmid    = {31301936},
  url     = {https://doi.org/10.1016/j.neuron.2019.06.010}
}

@article{kelley2019-31284572,
  author  = {Kelley, N. and Jeltema, D. and Duan, Y. and He, Y.},
  title   = {{The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation}},
  journal = {International journal of molecular sciences},
  year    = {2019},
  doi     = {10.3390/ijms20133328},
  pmid    = {31284572},
  url     = {https://doi.org/10.3390/ijms20133328}
}

@article{xu2019-31283973,
  author  = {Xu, Q. and Xu, W. and Cheng, H. and Yuan, H. and Tan, X.},
  title   = {{Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2}},
  journal = {Brain, behavior, and immunity},
  year    = {2019},
  doi     = {10.1016/j.bbi.2019.07.004},
  pmid    = {31283973},
  url     = {https://doi.org/10.1016/j.bbi.2019.07.004}
}

@article{jay2019-31265185,
  author  = {Jay, T. R. and von Saucken, V. E. and Muñoz, B. and Codocedo, J. F. and Atwood, B. K. and Lamb, B. T. and Landreth, G. E.},
  title   = {{TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23664},
  pmid    = {31265185},
  url     = {https://doi.org/10.1002/glia.23664}
}

@article{baik2019-31257151,
  author  = {Baik, S. H. and Kang, S. and Lee, W. and Choi, H. and Chung, S. and Kim, J. I. and Mook-Jung, I.},
  title   = {{A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease}},
  journal = {Cell metabolism},
  year    = {2019},
  doi     = {10.1016/j.cmet.2019.06.005},
  pmid    = {31257151},
  url     = {https://doi.org/10.1016/j.cmet.2019.06.005}
}

@article{jaitin2019-31257031,
  author  = {Jaitin, D. A. and Adlung, L. and Thaiss, C. A. and Weiner, A. and Li, B. and Descamps, H. and Lundgren, P. and Bleriot, C. and others},
  title   = {{Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner}},
  journal = {Cell},
  year    = {2019},
  doi     = {10.1016/j.cell.2019.05.054},
  pmid    = {31257031},
  url     = {https://doi.org/10.1016/j.cell.2019.05.054}
}

@article{kim2019-31297134,
  author  = {Kim, Seung Hyun and Noh, Min Young and Kim, Hee-Jin and Oh, Ki-Wook and Park, Jinseok and Lee, Sanggon and Moon, Yeonsil and Kim, Young-Eun and others},
  title   = {{A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation}},
  journal = {Dementia and neurocognitive disorders},
  year    = {2019},
  doi     = {10.12779/dnd.2019.18.2.33},
  pmid    = {31297134},
  url     = {https://doi.org/10.12779/dnd.2019.18.2.33}
}

@article{leyns2019-31235932,
  author  = {Leyns, C. E. G. and Gratuze, M. and Narasimhan, S. and Jain, N. and Koscal, L. J. and Jiang, H. and Manis, M. and Colonna, M. and others},
  title   = {{TREM2 function impedes tau seeding in neuritic plaques}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0433-0},
  pmid    = {31235932},
  url     = {https://doi.org/10.1038/s41593-019-0433-0}
}

@article{sheng2019-31219699,
  author  = {Sheng, L. and Chen, M. and Cai, K. and Song, Y. and Yu, D. and Zhang, H. and Xu, G.},
  title   = {{Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900527r},
  pmid    = {31219699},
  url     = {https://doi.org/10.1096/fj.201900527r}
}

@article{gotzl2019-31122931,
  author  = {Götzl, J. K. and Brendel, M. and Werner, G. and Parhizkar, S. and Sebastian Monasor, L. and Kleinberger, G. and Colombo, A. V. and Deussing, M. and others},
  title   = {{Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism}},
  journal = {EMBO molecular medicine},
  year    = {2019},
  doi     = {10.15252/emmm.201809711},
  pmid    = {31122931},
  url     = {https://doi.org/10.15252/emmm.201809711}
}

@article{long2019-31134514,
  author  = {Long, H. and Zhong, G. and Wang, C. and Zhang, J. and Zhang, Y. and Luo, J. and Shi, S.},
  title   = {{TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling}},
  journal = {Neurochemical research},
  year    = {2019},
  doi     = {10.1007/s11064-019-02817-1},
  pmid    = {31134514},
  url     = {https://doi.org/10.1007/s11064-019-02817-1}
}

@article{shirotani2019-31101881,
  author  = {Shirotani, K. and Hori, Y. and Yoshizaki, R. and Higuchi, E. and Colonna, M. and Saito, T. and Hashimoto, S. and others},
  title   = {{Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-43535-6},
  pmid    = {31101881},
  url     = {https://doi.org/10.1038/s41598-019-43535-6}
}

@article{subhramanyam2019-31077796,
  author  = {Subhramanyam, C. S. and Wang, C. and Hu, Q. and Dheen, S. T.},
  title   = {{Microglia-mediated neuroinflammation in neurodegenerative diseases}},
  journal = {Seminars in cell \& developmental biology},
  year    = {2019},
  doi     = {10.1016/j.semcdb.2019.05.004},
  pmid    = {31077796},
  url     = {https://doi.org/10.1016/j.semcdb.2019.05.004}
}

@article{delaguila2019-31068200,
  author  = {Del-Aguila, J. L. and Benitez, B. A. and Li, Z. and Dube, U. and Mihindukulasuriya, K. A. and Budde, J. P. and Farias, F. H. G. and Fernández, M. V. and others},
  title   = {{TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0319-3},
  pmid    = {31068200},
  url     = {https://doi.org/10.1186/s13024-019-0319-3}
}

@article{poyhonen2019-31105589,
  author  = {Pöyhönen, S. and Er, S. and Domanskyi, A. and Airavaara, M.},
  title   = {{Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury}},
  journal = {Frontiers in physiology},
  year    = {2019},
  doi     = {10.3389/fphys.2019.00486},
  pmid    = {31105589},
  url     = {https://doi.org/10.3389/fphys.2019.00486}
}

@article{bozaserrano2019-31006066,
  author  = {Boza-Serrano, A. and Ruiz, R. and Sanchez-Varo, R. and García-Revilla, J. and Yang, Y. and Jimenez-Ferrer, I. and Paulus, A. and Wennström, M. and others},
  title   = {{Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02013-z},
  pmid    = {31006066},
  url     = {https://doi.org/10.1007/s00401-019-02013-z}
}

@article{luo2019-31040784,
  author  = {Luo, H. and Xiang, Y. and Qu, X. and Liu, H. and Liu, C. and Li, G. and Han, L. and Qin, X.},
  title   = {{Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway}},
  journal = {Frontiers in pharmacology},
  year    = {2019},
  doi     = {10.3389/fphar.2019.00395},
  pmid    = {31040784},
  url     = {https://doi.org/10.3389/fphar.2019.00395}
}

@article{zhang2019-30936558,
  author  = {Zhang, P. and Kishimoto, Y. and Grammatikakis, I. and Gottimukkala, K. and Cutler, R. G. and Zhang, S. and Abdelmohsen, K. and Bohr, V. A. and others},
  title   = {{Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0372-9},
  pmid    = {30936558},
  url     = {https://doi.org/10.1038/s41593-019-0372-9}
}

@article{salafrigerio2019-31018141,
  author  = {Sala Frigerio, C. and Wolfs, L. and Fattorelli, N. and Thrupp, N. and Voytyuk, I. and Schmidt, I. and Mancuso, R. and Chen, W. T. and others},
  title   = {{The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques}},
  journal = {Cell reports},
  year    = {2019},
  doi     = {10.1016/j.celrep.2019.03.099},
  pmid    = {31018141},
  url     = {https://doi.org/10.1016/j.celrep.2019.03.099}
}

@article{wang2019-30930146,
  author  = {Wang, E. C. E. and Dai, Z. and Ferrante, A. W. and Drake, C. G. and Christiano, A. M.},
  title   = {{A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth}},
  journal = {Cell stem cell},
  year    = {2019},
  doi     = {10.1016/j.stem.2019.01.011},
  pmid    = {30930146},
  url     = {https://doi.org/10.1016/j.stem.2019.01.011}
}

@article{zhong2019-30911003,
  author  = {Zhong, L. and Xu, Y. and Zhuo, R. and Wang, T. and Wang, K. and Huang, R. and Wang, D. and Gao, Y. and others},
  title   = {{Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model}},
  journal = {Nature communications},
  year    = {2019},
  doi     = {10.1038/s41467-019-09118-9},
  pmid    = {30911003},
  url     = {https://doi.org/10.1038/s41467-019-09118-9}
}

@article{carpanini2019-30886620,
  author  = {Carpanini, S. M. and Torvell, M. and Morgan, B. P.},
  title   = {{Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System}},
  journal = {Frontiers in immunology},
  year    = {2019},
  doi     = {10.3389/fimmu.2019.00362},
  pmid    = {30886620},
  url     = {https://doi.org/10.3389/fimmu.2019.00362}
}

@article{mcintosh2019-30661261,
  author  = {McIntosh, A. and Mela, V. and Harty, C. and Minogue, A. M. and Costello, D. A. and Kerskens, C. and Lynch, M. A.},
  title   = {{Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2019},
  doi     = {10.1111/bpa.12704},
  pmid    = {30661261},
  url     = {https://doi.org/10.1111/bpa.12704}
}

@article{zhou2019-30756214,
  author  = {Zhou, J. and Yu, W. and Zhang, M. and Tian, X. and Li, Y. and Lü, Y.},
  title   = {{Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation}},
  journal = {Neurochemical research},
  year    = {2019},
  doi     = {10.1007/s11064-019-02748-x},
  pmid    = {30756214},
  url     = {https://doi.org/10.1007/s11064-019-02748-x}
}

@article{yang2019-30755589,
  author  = {Yang, Y. and Wang, H. and Kouadir, M. and Song, H. and Shi, F.},
  title   = {{Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors}},
  journal = {Cell death \& disease},
  year    = {2019},
  doi     = {10.1038/s41419-019-1413-8},
  pmid    = {30755589},
  url     = {https://doi.org/10.1038/s41419-019-1413-8}
}

@article{magno2019-30711010,
  author  = {Magno, Lorenza and Lessard, Christian B. and Martins, Marta and Lang, Verena and Cruz, Pedro E. and Asi, Yasmine T. and Katan, Matilda and Bilsland, Jamie and others},
  title   = {{Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0469-0},
  pmid    = {30711010},
  url     = {https://doi.org/10.1186/s13195-019-0469-0}
}

@article{dalmasso2019-30705288,
  author  = {Dalmasso, M. C. and Brusco, L. I. and Olivar, N. and Muchnik, C. and Hanses, C. and Milz, E. and Becker, J. and Heilmann-Heimbach, S. and others},
  title   = {{Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease}},
  journal = {Translational psychiatry},
  year    = {2019},
  doi     = {10.1038/s41398-019-0394-9},
  pmid    = {30705288},
  url     = {https://doi.org/10.1038/s41398-019-0394-9}
}

@article{tang2019-30683932,
  author  = {Tang, W. and Lv, B. and Yang, B. and Chen, Y. and Yuan, F. and Ma, L. and Chen, S. and Zhang, S. and others},
  title   = {{TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway}},
  journal = {Oncogenesis},
  year    = {2019},
  doi     = {10.1038/s41389-018-0115-x},
  pmid    = {30683932},
  url     = {https://doi.org/10.1038/s41389-018-0115-x}
}

@article{liu2019-30684126,
  author  = {Liu, A. H. and Chu, M. and Wang, Y. P.},
  title   = {{Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice}},
  journal = {Neuroscience bulletin},
  year    = {2019},
  doi     = {10.1007/s12264-018-0324-5},
  pmid    = {30684126},
  url     = {https://doi.org/10.1007/s12264-018-0324-5}
}

@article{suarezcalvet2019-30630532,
  author  = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others},
  title   = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-018-0301-5},
  pmid    = {30630532},
  url     = {https://doi.org/10.1186/s13024-018-0301-5}
}

@article{parhizkar2019-30617257,
  author  = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others},
  title   = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-018-0296-9},
  pmid    = {30617257},
  url     = {https://doi.org/10.1038/s41593-018-0296-9}
}

@article{takatori2019-30747419,
  author  = {Takatori, Sho and Wang, Wenbo and Iguchi, Akihiro and Tomita, Taisuke},
  title   = {{Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms}},
  journal = {Advances in experimental medicine and biology},
  year    = {2019},
  doi     = {10.1007/978-3-030-05542-4_5},
  pmid    = {30747419},
  url     = {https://doi.org/10.1007/978-3-030-05542-4_5}
}

@article{larosa2019-31594217,
  author  = {La Rosa, Francesca and Saresella, Marina and Marventano, Ivana and Piancone, Federica and Ripamonti, Enrico and Al-Daghri, Nasser and Bazzini, Chiara and Zoia, Chiara Paola and others},
  title   = {{Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-181259},
  pmid    = {31594217},
  url     = {https://doi.org/10.3233/jad-181259}
}

@article{gussago2019-30997915,
  author  = {Gussago, C and Casati, M and Ferri, E and Arosio, B},
  title   = {{The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore}},
  journal = {The Journal of frailty \& aging},
  year    = {2019},
  doi     = {10.14283/jfa.2018.43},
  pmid    = {30997915},
  url     = {https://doi.org/10.14283/jfa.2018.43}
}

@article{zhou2019-30883352,
  author  = {Zhou, S. L. and Tan, C. C. and Hou, X. H. and Cao, X. P. and Tan, L. and Yu, J. T.},
  title   = {{TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-181038},
  pmid    = {30883352},
  url     = {https://doi.org/10.3233/jad-181038}
}

@article{wolfe2018-30587772,
  author  = {Wolfe, C. M. and Fitz, N. F. and Nam, K. N. and Lefterov, I. and Koldamova, R.},
  title   = {{The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms20010081},
  pmid    = {30587772},
  url     = {https://doi.org/10.3390/ijms20010081}
}

@article{gratuze2018-30572908,
  author  = {Gratuze, M. and Leyns, C. E. G. and Holtzman, D. M.},
  title   = {{New insights into the role of TREM2 in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0298-9},
  pmid    = {30572908},
  url     = {https://doi.org/10.1186/s13024-018-0298-9}
}

@article{marttinen2018-30618585,
  author  = {Marttinen, Mikael and Takalo, Mari and Natunen, Teemu and Wittrahm, Rebekka and Gabbouj, Sami and Kemppainen, Susanna and Leinonen, Ville and Tanila, Heikki and others},
  title   = {{Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease}},
  journal = {Frontiers in neuroscience},
  year    = {2018},
  doi     = {10.3389/fnins.2018.00963},
  pmid    = {30618585},
  url     = {https://doi.org/10.3389/fnins.2018.00963}
}

@article{linnartzgerlach2019-30548312,
  author  = {Linnartz-Gerlach, B. and Bodea, L. G. and Klaus, C. and Ginolhac, A. and Halder, R. and Sinkkonen, L. and Walter, J. and Colonna, M. and others},
  title   = {{TREM2 triggers microglial density and age-related neuronal loss}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23563},
  pmid    = {30548312},
  url     = {https://doi.org/10.1002/glia.23563}
}

@article{shi2018-30140051,
  author  = {Shi, Y. and Holtzman, D. M.},
  title   = {{Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight}},
  journal = {Nature reviews. Immunology},
  year    = {2018},
  doi     = {10.1038/s41577-018-0051-1},
  pmid    = {30140051},
  url     = {https://doi.org/10.1038/s41577-018-0051-1}
}

@article{zheng2018-30532704,
  author  = {Zheng, H. and Cheng, B. and Li, Y. and Li, X. and Chen, X. and Zhang, Y. W.},
  title   = {{TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00395},
  pmid    = {30532704},
  url     = {https://doi.org/10.3389/fnagi.2018.00395}
}

@article{thawkar2019-30502599,
  author  = {Thawkar, B. S. and Kaur, G.},
  title   = {{Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease}},
  journal = {Journal of neuroimmunology},
  year    = {2019},
  doi     = {10.1016/j.jneuroim.2018.11.010},
  pmid    = {30502599},
  url     = {https://doi.org/10.1016/j.jneuroim.2018.11.010}
}

@article{katsumoto2018-30498474,
  author  = {Katsumoto, A. and Takeuchi, H. and Takahashi, K. and Tanaka, F.},
  title   = {{Microglia in Alzheimer's Disease: Risk Factors and Inflammation}},
  journal = {Frontiers in neurology},
  year    = {2018},
  doi     = {10.3389/fneur.2018.00978},
  pmid    = {30498474},
  url     = {https://doi.org/10.3389/fneur.2018.00978}
}

@article{claes2019-30442540,
  author  = {Claes, C. and Van Den Daele, J. and Boon, R. and Schouteden, S. and Colombo, A. and Monasor, L. S. and Fiers, M. and Ordovás, L. and others},
  title   = {{Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2019},
  doi     = {10.1016/j.jalz.2018.09.006},
  pmid    = {30442540},
  url     = {https://doi.org/10.1016/j.jalz.2018.09.006}
}

@article{michetti2019-30144068,
  author  = {Michetti, F. and D'Ambrosi, N. and Toesca, A. and Puglisi, M. A. and Serrano, A. and Marchese, E. and Corvino, V. and Geloso, M. C.},
  title   = {{The S100B story: from biomarker to active factor in neural injury}},
  journal = {Journal of neurochemistry},
  year    = {2019},
  doi     = {10.1111/jnc.14574},
  pmid    = {30144068},
  url     = {https://doi.org/10.1111/jnc.14574}
}

@article{litvinchuk2018-30415998,
  author  = {Litvinchuk, A. and Wan, Y. W. and Swartzlander, D. B. and Chen, F. and Cole, A. and Propson, N. E. and Wang, Q. and Zhang, B. and others},
  title   = {{Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.10.031},
  pmid    = {30415998},
  url     = {https://doi.org/10.1016/j.neuron.2018.10.031}
}

@article{gisslen2019-30568991,
  author  = {Gisslén, M. and Heslegrave, A. and Veleva, E. and Yilmaz, A. and Andersson, L. M. and Hagberg, L. and Spudich, S. and Fuchs, D. and others},
  title   = {{CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection}},
  journal = {Neurology(R) neuroimmunology \& neuroinflammation},
  year    = {2019},
  doi     = {10.1212/nxi.0000000000000512},
  pmid    = {30568991},
  url     = {https://doi.org/10.1212/nxi.0000000000000512}
}

@article{lessard2018-30341064,
  author  = {Lessard, C. B. and Malnik, S. L. and Zhou, Y. and Ladd, T. B. and Cruz, P. E. and Ran, Y. and Mahan, T. E. and Chakrabaty, P. and others},
  title   = {{High-affinity interactions and signal transduction between Aβ oligomers and TREM2}},
  journal = {EMBO molecular medicine},
  year    = {2018},
  doi     = {10.15252/emmm.201809027},
  pmid    = {30341064},
  url     = {https://doi.org/10.15252/emmm.201809027}
}

@article{ulland2018-30266932,
  author  = {Ulland, T. K. and Colonna, M.},
  title   = {{TREM2 - a key player in microglial biology and Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2018},
  doi     = {10.1038/s41582-018-0072-1},
  pmid    = {30266932},
  url     = {https://doi.org/10.1038/s41582-018-0072-1}
}

@article{rauchmann2019-30458365,
  author  = {Rauchmann, B. S. and Schneider-Axmann, T. and Alexopoulos, P. and Perneczky, R. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum}},
  journal = {Neurobiology of aging},
  year    = {2019},
  doi     = {10.1016/j.neurobiolaging.2018.10.022},
  pmid    = {30458365},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2018.10.022}
}

@article{sayed2018-30232263,
  author  = {Sayed, F. A. and Telpoukhovskaia, M. and Kodama, L. and Li, Y. and Zhou, Y. and Le, D. and Hauduc, A. and Ludwig, C. and others},
  title   = {{Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2018},
  doi     = {10.1073/pnas.1811411115},
  pmid    = {30232263},
  url     = {https://doi.org/10.1073/pnas.1811411115}
}

@article{xiang2018-30185230,
  author  = {Xiang, X. and Piers, T. M. and Wefers, B. and Zhu, K. and Mallach, A. and Brunner, B. and Kleinberger, G. and Song, W. and others},
  title   = {{The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0280-6},
  pmid    = {30185230},
  url     = {https://doi.org/10.1186/s13024-018-0280-6}
}

@article{liu2018-30171911,
  author  = {Liu, D. and Cao, B. and Zhao, Y. and Huang, H. and McIntyre, R. S. and Rosenblat, J. D. and Zhou, H.},
  title   = {{Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis}},
  journal = {Neuroscience letters},
  year    = {2018},
  doi     = {10.1016/j.neulet.2018.08.038},
  pmid    = {30171911},
  url     = {https://doi.org/10.1016/j.neulet.2018.08.038}
}

@article{tzeng2018-30127003,
  author  = {Tzeng, Te-Chen and Hasegawa, Yuto and Iguchi, Risa and Cheung, Amy and Caffrey, Daniel R and Thatcher, Elizabeth Jeanne and Mao, Wenjie and Germain, Gail and others},
  title   = {{Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2018},
  doi     = {10.1073/pnas.1801802115},
  pmid    = {30127003},
  url     = {https://doi.org/10.1073/pnas.1801802115}
}

@article{woollacott2018-30111356,
  author  = {Woollacott, I. O. C. and Nicholas, J. M. and Heslegrave, A. and Heller, C. and Foiani, M. S. and Dick, K. M. and Russell, L. L. and Paterson, R. W. and others},
  title   = {{Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0405-8},
  pmid    = {30111356},
  url     = {https://doi.org/10.1186/s13195-018-0405-8}
}

@article{konishi2018-30127720,
  author  = {Konishi, H. and Kiyama, H.},
  title   = {{Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2018},
  doi     = {10.3389/fncel.2018.00206},
  pmid    = {30127720},
  url     = {https://doi.org/10.3389/fncel.2018.00206}
}

@article{garciareitboeck2018-30157425,
  author  = {Garcia-Reitboeck, P. and Phillips, A. and Piers, T. M. and Villegas-Llerena, C. and Butler, M. and Mallach, A. and Rodrigues, C. and Arber, C. E. and others},
  title   = {{Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis}},
  journal = {Cell reports},
  year    = {2018},
  doi     = {10.1016/j.celrep.2018.07.094},
  pmid    = {30157425},
  url     = {https://doi.org/10.1016/j.celrep.2018.07.094}
}

@article{carmona2018-30033062,
  author  = {Carmona, S. and Zahs, K. and Wu, E. and Dakin, K. and Bras, J. and Guerreiro, R.},
  title   = {{The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders}},
  journal = {The Lancet. Neurology},
  year    = {2018},
  doi     = {10.1016/s1474-4422(18)30232-1},
  pmid    = {30033062},
  url     = {https://doi.org/10.1016/s1474-4422(18)30232-1}
}

@article{zhou2018-30038567,
  author  = {Zhou, Y. and Ulland, T. K. and Colonna, M.},
  title   = {{TREM2-Dependent Effects on Microglia in Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00202},
  pmid    = {30038567},
  url     = {https://doi.org/10.3389/fnagi.2018.00202}
}

@article{deming2018-3f7a9435,
  author  = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others},
  title   = {{The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk}},
  journal = {Science translational medicine},
  year    = {2018},
  doi     = {10.1101/352179},
  url     = {https://doi.org/10.1101/352179}
}

@article{deming2018-29889572,
  author  = {Deming, Yuetiva and Li, Zeran and Benitez, Bruno A and Cruchaga, Carlos},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?}},
  journal = {Expert opinion on therapeutic targets},
  year    = {2018},
  doi     = {10.1080/14728222.2018.1486823},
  pmid    = {29889572},
  url     = {https://doi.org/10.1080/14728222.2018.1486823}
}

@article{chenghathaway2018-29859094,
  author  = {Cheng-Hathaway, P. J. and Reed-Geaghan, E. G. and Jay, T. R. and Casali, B. T. and Bemiller, S. M. and Puntambekar, S. S. and von Saucken, V. E. and Williams, R. Y. and others},
  title   = {{The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0262-8},
  pmid    = {29859094},
  url     = {https://doi.org/10.1186/s13024-018-0262-8}
}

@article{jiang2018-29362997,
  author  = {Jiang, T. and Zhang, Y. D. and Gao, Q. and Ou, Z. and Gong, P. Y. and Shi, J. Q. and Wu, L. and Zhou, J. S.},
  title   = {{TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response}},
  journal = {Inflammation},
  year    = {2018},
  doi     = {10.1007/s10753-018-0735-5},
  pmid    = {29362997},
  url     = {https://doi.org/10.1007/s10753-018-0735-5}
}

@article{sudom2018-29794134,
  author  = {Sudom, A. and Talreja, S. and Danao, J. and Bragg, E. and Kegel, R. and Min, X. and Richardson, J. and Zhang, Z. and others},
  title   = {{Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2}},
  journal = {The Journal of biological chemistry},
  year    = {2018},
  doi     = {10.1074/jbc.ra118.002352},
  pmid    = {29794134},
  url     = {https://doi.org/10.1074/jbc.ra118.002352}
}

@article{rangaraju2018-29784049,
  author  = {Rangaraju, S. and Dammer, E. B. and Raza, S. A. and Rathakrishnan, P. and Xiao, H. and Gao, T. and Duong, D. M. and Pennington, M. W. and others},
  title   = {{Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0254-8},
  pmid    = {29784049},
  url     = {https://doi.org/10.1186/s13024-018-0254-8}
}

@article{li2019-29663649,
  author  = {Li, C. and Zhao, B. and Lin, C. and Gong, Z. and An, X.},
  title   = {{TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling}},
  journal = {Cell biology international},
  year    = {2019},
  doi     = {10.1002/cbin.10975},
  pmid    = {29663649},
  url     = {https://doi.org/10.1002/cbin.10975}
}

@article{filipello2018-29752066,
  author  = {Filipello, F. and Morini, R. and Corradini, I. and Zerbi, V. and Canzi, A. and Michalski, B. and Erreni, M. and Markicevic, M. and others},
  title   = {{The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity}},
  journal = {Immunity},
  year    = {2018},
  doi     = {10.1016/j.immuni.2018.04.016},
  pmid    = {29752066},
  url     = {https://doi.org/10.1016/j.immuni.2018.04.016}
}

@article{liu2018-29669582,
  author  = {Liu, Y. and Zhang, Y. and Zheng, X. and Fang, T. and Yang, X. and Luo, X. and Guo, A. and Newell, K. A. and others},
  title   = {{Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2018},
  doi     = {10.1186/s12974-018-1141-5},
  pmid    = {29669582},
  url     = {https://doi.org/10.1186/s12974-018-1141-5}
}

@article{stephenson2018-29513402,
  author  = {Stephenson, J. and Nutma, E. and van der Valk, P. and Amor, S.},
  title   = {{Inflammation in CNS neurodegenerative diseases}},
  journal = {Immunology},
  year    = {2018},
  doi     = {10.1111/imm.12922},
  pmid    = {29513402},
  url     = {https://doi.org/10.1111/imm.12922}
}

@article{li2018-29655369,
  author  = {Li, J. T. and Zhang, Y.},
  title   = {{TREM2 regulates innate immunity in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2018},
  doi     = {10.1186/s12974-018-1148-y},
  pmid    = {29655369},
  url     = {https://doi.org/10.1186/s12974-018-1148-y}
}

@article{wendeln2018-29643512,
  author  = {Wendeln, A. C. and Degenhardt, K. and Kaurani, L. and Gertig, M. and Ulas, T. and Jain, G. and Wagner, J. and Häsler, L. M. and others},
  title   = {{Innate immune memory in the brain shapes neurological disease hallmarks}},
  journal = {Nature},
  year    = {2018},
  doi     = {10.1038/s41586-018-0023-4},
  pmid    = {29643512},
  url     = {https://doi.org/10.1038/s41586-018-0023-4}
}

@article{zhang2018-29621548,
  author  = {Zhang, Y. and Feng, S. and Nie, K. and Li, Y. and Gao, Y. and Gan, R. and Wang, L. and Li, B. and others},
  title   = {{TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2018},
  doi     = {10.1016/j.bbrc.2018.03.226},
  pmid    = {29621548},
  url     = {https://doi.org/10.1016/j.bbrc.2018.03.226}
}

@article{brownjohn2018-29606617,
  author  = {Brownjohn, P. W. and Smith, J. and Solanki, R. and Lohmann, E. and Houlden, H. and Hardy, J. and Dietmann, S. and Livesey, F. J.},
  title   = {{Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia}},
  journal = {Stem cell reports},
  year    = {2018},
  doi     = {10.1016/j.stemcr.2018.03.003},
  pmid    = {29606617},
  url     = {https://doi.org/10.1016/j.stemcr.2018.03.003}
}

@article{cheng2018-29599291,
  author  = {Cheng, Q. and Danao, J. and Talreja, S. and Wen, P. and Yin, J. and Sun, N. and Li, C. M. and Chui, D. and others},
  title   = {{TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function}},
  journal = {The Journal of biological chemistry},
  year    = {2018},
  doi     = {10.1074/jbc.ra118.001848},
  pmid    = {29599291},
  url     = {https://doi.org/10.1074/jbc.ra118.001848}
}

@article{zhong2018-29587871,
  author  = {Zhong, L. and Wang, Z. and Wang, D. and Martens, Y. A. and Wu, L. and Xu, Y. and Wang, K. and others},
  title   = {{Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0247-7},
  pmid    = {29587871},
  url     = {https://doi.org/10.1186/s13024-018-0247-7}
}

@article{casati2018-29377401,
  author  = {Casati, M. and Ferri, E. and Gussago, C. and Mazzola, P. and Abbate, C. and Bellelli, G. and Mari, D. and Cesari, M. and others},
  title   = {{Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease}},
  journal = {European journal of neurology},
  year    = {2018},
  doi     = {10.1111/ene.13583},
  pmid    = {29377401},
  url     = {https://doi.org/10.1111/ene.13583}
}

@article{bekris2018-29685286,
  author  = {Bekris, L. M. and Khrestian, M. and Dyne, E. and Shao, Y. and Pillai, J. A. and Rao, S. M. and Bemiller, S. M. and Lamb, B. and others},
  title   = {{Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease}},
  journal = {Journal of neuroimmunology},
  year    = {2018},
  doi     = {10.1016/j.jneuroim.2018.03.003},
  pmid    = {29685286},
  url     = {https://doi.org/10.1016/j.jneuroim.2018.03.003}
}

@article{lee2018-29518357,
  author  = {Lee, C. Y. D. and Daggett, A. and Gu, X. and Jiang, L. L. and Langfelder, P. and Li, X. and Wang, N. and Zhao, Y. and others},
  title   = {{Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.02.002},
  pmid    = {29518357},
  url     = {https://doi.org/10.1016/j.neuron.2018.02.002}
}

@article{rajendran2018-29563239,
  author  = {Rajendran, L. and Paolicelli, R. C.},
  title   = {{Microglia-Mediated Synapse Loss in Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2018},
  doi     = {10.1523/jneurosci.1136-17.2017},
  pmid    = {29563239},
  url     = {https://doi.org/10.1523/jneurosci.1136-17.2017}
}

@article{zhao2018-29518356,
  author  = {Zhao, Y. and Wu, X. and Li, X. and Jiang, L. L. and Gui, X. and Liu, Y. and Sun, Y. and Zhu, B. and others},
  title   = {{TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.01.031},
  pmid    = {29518356},
  url     = {https://doi.org/10.1016/j.neuron.2018.01.031}
}

@article{olah2018-29416036,
  author  = {Olah, M. and Patrick, E. and Villani, A. C. and Xu, J. and White, C. C. and Ryan, K. J. and Piehowski, P. and Kapasi, A. and others},
  title   = {{A transcriptomic atlas of aged human microglia}},
  journal = {Nature communications},
  year    = {2018},
  doi     = {10.1038/s41467-018-02926-5},
  pmid    = {29416036},
  url     = {https://doi.org/10.1038/s41467-018-02926-5}
}

@article{mrdjen2018-29426702,
  author  = {Mrdjen, D. and Pavlovic, A. and Hartmann, F. J. and Schreiner, B. and Utz, S. G. and Leung, B. P. and Lelios, I. and Heppner, F. L. and others},
  title   = {{High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease}},
  journal = {Immunity},
  year    = {2018},
  doi     = {10.1016/j.immuni.2018.01.011},
  pmid    = {29426702},
  url     = {https://doi.org/10.1016/j.immuni.2018.01.011}
}

@article{ren2018-29407460,
  author  = {Ren, M. and Guo, Y. and Wei, X. and Yan, S. and Qin, Y. and Zhang, X. and Jiang, F. and Lou, H.},
  title   = {{TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease}},
  journal = {Experimental neurology},
  year    = {2018},
  doi     = {10.1016/j.expneurol.2018.01.016},
  pmid    = {29407460},
  url     = {https://doi.org/10.1016/j.expneurol.2018.01.016}
}

@article{mecca2018-29361745,
  author  = {Mecca, C. and Giambanco, I. and Donato, R. and Arcuri, C.},
  title   = {{Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms19010318},
  pmid    = {29361745},
  url     = {https://doi.org/10.3390/ijms19010318}
}

@article{song2018-29321225,
  author  = {Song, W. M. and Joshita, S. and Zhou, Y. and Ulland, T. K. and Gilfillan, S. and Colonna, M.},
  title   = {{Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism}},
  journal = {The Journal of experimental medicine},
  year    = {2018},
  doi     = {10.1084/jem.20171529},
  pmid    = {29321225},
  url     = {https://doi.org/10.1084/jem.20171529}
}

@article{su2018-29322490,
  author  = {Su, W. H. and Shi, Z. H. and Liu, S. L. and Wang, X. D. and Liu, S. and Ji, Y.},
  title   = {{The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations}},
  journal = {Annals of human genetics},
  year    = {2018},
  doi     = {10.1111/ahg.12241},
  pmid    = {29322490},
  url     = {https://doi.org/10.1111/ahg.12241}
}

@article{kang2018-29040522,
  author  = {Kang, S. S. and Kurti, A. and Baker, K. E. and Liu, C. C. and Colonna, M. and Ulrich, J. D. and Holtzman, D. M. and Bu, G. and others},
  title   = {{Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal}},
  journal = {Human molecular genetics},
  year    = {2018},
  doi     = {10.1093/hmg/ddx366},
  pmid    = {29040522},
  url     = {https://doi.org/10.1093/hmg/ddx366}
}

@article{dansokho2018-29273951,
  author  = {Dansokho, Cira and Heneka, Michael Thomas},
  title   = {{Neuroinflammatory responses in Alzheimer's disease}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2018},
  doi     = {10.1007/s00702-017-1831-7},
  pmid    = {29273951},
  url     = {https://doi.org/10.1007/s00702-017-1831-7}
}

@article{jones2017-29312321,
  author  = {Jones, S. V. and Kounatidis, I.},
  title   = {{Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans}},
  journal = {Frontiers in immunology},
  year    = {2017},
  doi     = {10.3389/fimmu.2017.01805},
  pmid    = {29312321},
  url     = {https://doi.org/10.3389/fimmu.2017.01805}
}

@article{venegas2017-29293211,
  author  = {Venegas, C. and Kumar, S. and Franklin, B. S. and Dierkes, T. and Brinkschulte, R. and Tejera, D. and Vieira-Saecker, A. and Schwartz, S. and others},
  title   = {{Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease}},
  journal = {Nature},
  year    = {2017},
  doi     = {10.1038/nature25158},
  pmid    = {29293211},
  url     = {https://doi.org/10.1038/nature25158}
}

@article{zhang2018-29104108,
  author  = {Zhang, X. and Wang, W. and Li, P. and Wang, X. and Ni, K.},
  title   = {{High TREM2 expression correlates with poor prognosis in gastric cancer}},
  journal = {Human pathology},
  year    = {2018},
  doi     = {10.1016/j.humpath.2017.10.026},
  pmid    = {29104108},
  url     = {https://doi.org/10.1016/j.humpath.2017.10.026}
}

@article{fahrenhold2018-28987033,
  author  = {Fahrenhold, M. and Rakic, S. and Classey, J. and Brayne, C. and Ince, P. G. and Nicoll, J. A. R. and Boche, D. and MRC-CFAS},
  title   = {{TREM2 expression in the human brain: a marker of monocyte recruitment?}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2018},
  doi     = {10.1111/bpa.12564},
  pmid    = {28987033},
  url     = {https://doi.org/10.1111/bpa.12564}
}

@article{zhang2017-29180839,
  author  = {Zhang, Xiaobao and Yan, Fang and Cui, Jizheng and Wu, Yong and Luan, Hengfei and Yin, Miaomiao and Zhao, Zhibin and Feng, Jiying and others},
  title   = {{Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia}},
  journal = {Mediators of inflammation},
  year    = {2017},
  doi     = {10.1155/2017/9340610},
  pmid    = {29180839},
  url     = {https://doi.org/10.1155/2017/9340610}
}

@article{bemiller2017-29037207,
  author  = {Bemiller, S. M. and McCray, T. J. and Allan, K. and Formica, S. V. and Xu, G. and Wilson, G. and Kokiko-Cochran, O. N. and Crish, S. D. and others},
  title   = {{TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0216-6},
  pmid    = {29037207},
  url     = {https://doi.org/10.1186/s13024-017-0216-6}
}

@article{hu2018-29051087,
  author  = {Hu, L. Y. and Zhou, Y. and Cui, W. Q. and Hu, X. M. and Du, L. X. and Mi, W. L. and Chu, Y. X. and Wu, G. C. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2018},
  doi     = {10.1016/j.bbi.2017.10.011},
  pmid    = {29051087},
  url     = {https://doi.org/10.1016/j.bbi.2017.10.011}
}

@article{condello2018-29169609,
  author  = {Condello, C. and Yuan, P. and Grutzendler, J.},
  title   = {{Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging}},
  journal = {Biological psychiatry},
  year    = {2018},
  doi     = {10.1016/j.biopsych.2017.10.007},
  pmid    = {29169609},
  url     = {https://doi.org/10.1016/j.biopsych.2017.10.007}
}

@article{leyns2017-29073081,
  author  = {Leyns, C. E. G. and Ulrich, J. D. and Finn, M. B. and Stewart, F. R. and Koscal, L. J. and Remolina Serrano, J. and Robinson, G. O. and Anderson, E. and others},
  title   = {{TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2017},
  doi     = {10.1073/pnas.1710311114},
  pmid    = {29073081},
  url     = {https://doi.org/10.1073/pnas.1710311114}
}

@article{schlepckow2017-28855300,
  author  = {Schlepckow, K. and Kleinberger, G. and Fukumori, A. and Feederle, R. and Lichtenthaler, S. F. and Steiner, H. and Haass, C.},
  title   = {{An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201707672},
  pmid    = {28855300},
  url     = {https://doi.org/10.15252/emmm.201707672}
}

@article{thornton2017-28855301,
  author  = {Thornton, P. and Sevalle, J. and Deery, M. J. and Fraser, G. and Zhou, Y. and Ståhl, S. and Franssen, E. H. and Dodd, R. B. and others},
  title   = {{TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201707673},
  pmid    = {28855301},
  url     = {https://doi.org/10.15252/emmm.201707673}
}

@article{feuerbach2017-28923481,
  author  = {Feuerbach, D. and Schindler, P. and Barske, C. and Joller, S. and Beng-Louka, E. and Worringer, K. A. and Kommineni, S. and Kaykas, A. and others},
  title   = {{ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157}},
  journal = {Neuroscience letters},
  year    = {2017},
  doi     = {10.1016/j.neulet.2017.09.034},
  pmid    = {28923481},
  url     = {https://doi.org/10.1016/j.neulet.2017.09.034}
}

@article{kim2017-28894284,
  author  = {Kim, S. M. and Mun, B. R. and Lee, S. J. and Joh, Y. and Lee, H. Y. and Ji, K. Y. and Choi, H. R. and Lee, E. H. and others},
  title   = {{TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-11634-x},
  pmid    = {28894284},
  url     = {https://doi.org/10.1038/s41598-017-11634-x}
}

@article{salter2017-28886007,
  author  = {Salter, M. W. and Stevens, B.},
  title   = {{Microglia emerge as central players in brain disease}},
  journal = {Nature medicine},
  year    = {2017},
  doi     = {10.1038/nm.4397},
  pmid    = {28886007},
  url     = {https://doi.org/10.1038/nm.4397}
}

@article{krasemann2017-28930663,
  author  = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others},
  title   = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}},
  journal = {Immunity},
  year    = {2017},
  doi     = {10.1016/j.immuni.2017.08.008},
  pmid    = {28930663},
  url     = {https://doi.org/10.1016/j.immuni.2017.08.008}
}

@article{fuger2017-28846081,
  author  = {Füger, P. and Hefendehl, J. K. and Veeraraghavalu, K. and Wendeln, A. C. and Schlosser, C. and Obermüller, U. and Wegenast-Braun, B. M. and Neher, J. J. and others},
  title   = {{Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging}},
  journal = {Nature neuroscience},
  year    = {2017},
  doi     = {10.1038/nn.4631},
  pmid    = {28846081},
  url     = {https://doi.org/10.1038/nn.4631}
}

@article{jay2017-28768545,
  author  = {Jay, T. R. and von Saucken, V. E. and Landreth, G. E.},
  title   = {{TREM2 in Neurodegenerative Diseases}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0197-5},
  pmid    = {28768545},
  url     = {https://doi.org/10.1186/s13024-017-0197-5}
}

@article{ulland2017-28802038,
  author  = {Ulland, T. K. and Song, W. M. and Huang, S. C. and Ulrich, J. D. and Sergushichev, A. and Beatty, W. L. and Loboda, A. A. and Zhou, Y. and others},
  title   = {{TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease}},
  journal = {Cell},
  year    = {2017},
  doi     = {10.1016/j.cell.2017.07.023},
  pmid    = {28802038},
  url     = {https://doi.org/10.1016/j.cell.2017.07.023}
}

@article{sims2017-28714976,
  author  = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others},
  title   = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2017},
  doi     = {10.1038/ng.3916},
  pmid    = {28714976},
  url     = {https://doi.org/10.1038/ng.3916}
}

@article{zhong2017-28680398,
  author  = {Zhong, L. and Zhang, Z. L. and Li, X. and Liao, C. and Mou, P. and Wang, T. and Wang, Z. and others},
  title   = {{TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00204},
  pmid    = {28680398},
  url     = {https://doi.org/10.3389/fnagi.2017.00204}
}

@article{hauremirande2017-28612290,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Fanutza, T. and Kim, S. H. and Klein, W. L. and Glabe, C. and Readhead, B. and Dudley, J. T. and others},
  title   = {{Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology}},
  journal = {Acta neuropathologica},
  year    = {2017},
  doi     = {10.1007/s00401-017-1737-3},
  pmid    = {28612290},
  url     = {https://doi.org/10.1007/s00401-017-1737-3}
}

@article{wu2017-28592261,
  author  = {Wu, R. and Li, X. and Xu, P. and Huang, L. and Cheng, J. and Huang, X. and Jiang, J. and Wu, L. J. and others},
  title   = {{TREM2 protects against cerebral ischemia/reperfusion injury}},
  journal = {Molecular brain},
  year    = {2017},
  doi     = {10.1186/s13041-017-0296-9},
  pmid    = {28592261},
  url     = {https://doi.org/10.1186/s13041-017-0296-9}
}

@article{kleinberger2017-28559417,
  author  = {Kleinberger, G. and Brendel, M. and Mracsko, E. and Wefers, B. and Groeneweg, L. and Xiang, X. and Focke, C. and Deußing, M. and others},
  title   = {{The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism}},
  journal = {The EMBO journal},
  year    = {2017},
  doi     = {10.15252/embj.201796516},
  pmid    = {28559417},
  url     = {https://doi.org/10.15252/embj.201796516}
}

@article{castranio2017-28502803,
  author  = {Castranio, E. L. and Mounier, A. and Wolfe, C. M. and Nam, K. N. and Fitz, N. F. and Letronne, F. and Schug, J. and Koldamova, R. and others},
  title   = {{Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury}},
  journal = {Neurobiology of disease},
  year    = {2017},
  doi     = {10.1016/j.nbd.2017.05.006},
  pmid    = {28502803},
  url     = {https://doi.org/10.1016/j.nbd.2017.05.006}
}

@article{mazaheri2017-28483841,
  author  = {Mazaheri, F. and Snaidero, N. and Kleinberger, G. and Madore, C. and Daria, A. and Werner, G. and Krasemann, S. and Capell, A. and others},
  title   = {{TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury}},
  journal = {EMBO reports},
  year    = {2017},
  doi     = {10.15252/embr.201743922},
  pmid    = {28483841},
  url     = {https://doi.org/10.15252/embr.201743922}
}

@article{shi2017-28566429,
  author  = {Shi, Q. and Chowdhury, S. and Ma, R. and Le, K. X. and Hong, S. and Caldarone, B. J. and others},
  title   = {{Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice}},
  journal = {Science translational medicine},
  year    = {2017},
  doi     = {10.1126/scitranslmed.aaf6295},
  pmid    = {28566429},
  url     = {https://doi.org/10.1126/scitranslmed.aaf6295}
}

@article{lee2018-28456941,
  author  = {Lee, C. H. and Jeon, S. J. and Cho, K. S. and Moon, E. and Sapkota, A. and Jun, H. S. and Ryu, J. H. and Choi, J. W.},
  title   = {{Activation of Glucagon-Like Peptide-1 Receptor Promotes Neuroprotection in Experimental Autoimmune Encephalomyelitis by Reducing Neuroinflammatory Responses}},
  journal = {Molecular neurobiology},
  year    = {2018},
  doi     = {10.1007/s12035-017-0550-2},
  pmid    = {28456941},
  url     = {https://doi.org/10.1007/s12035-017-0550-2}
}

@article{yeh2017-28442216,
  author  = {Yeh, F. L. and Hansen, D. V. and Sheng, M.},
  title   = {{TREM2, Microglia, and Neurodegenerative Diseases}},
  journal = {Trends in molecular medicine},
  year    = {2017},
  doi     = {10.1016/j.molmed.2017.03.008},
  pmid    = {28442216},
  url     = {https://doi.org/10.1016/j.molmed.2017.03.008}
}

@article{kober2017-28432014,
  author  = {Kober, D. L. and Brett, T. J.},
  title   = {{TREM2-Ligand Interactions in Health and Disease}},
  journal = {Journal of molecular biology},
  year    = {2017},
  doi     = {10.1016/j.jmb.2017.04.004},
  pmid    = {28432014},
  url     = {https://doi.org/10.1016/j.jmb.2017.04.004}
}

@article{ozaki2017-28412600,
  author  = {Ozaki, Y. and Yoshino, Y. and Yamazaki, K. and Sao, T. and Mori, Y. and Ochi, S. and Yoshida, T. and Mori, T. and others},
  title   = {{DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease}},
  journal = {Journal of psychiatric research},
  year    = {2017},
  doi     = {10.1016/j.jpsychires.2017.04.003},
  pmid    = {28412600},
  url     = {https://doi.org/10.1016/j.jpsychires.2017.04.003}
}

@article{ulrich2017-28426958,
  author  = {Ulrich, J. D. and Ulland, T. K. and Colonna, M. and Holtzman, D. M.},
  title   = {{Elucidating the Role of TREM2 in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.02.042},
  pmid    = {28426958},
  url     = {https://doi.org/10.1016/j.neuron.2017.02.042}
}

@article{abud2017-28426964,
  author  = {Abud, E. M. and Ramirez, R. N. and Martinez, E. S. and Healy, L. M. and Nguyen, C. H. H. and Newman, S. A. and Yeromin, A. V. and Scarfone, V. M. and others},
  title   = {{iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.03.042},
  pmid    = {28426964},
  url     = {https://doi.org/10.1016/j.neuron.2017.03.042}
}

@article{jendresen2017-28320424,
  author  = {Jendresen, C. and Årskog, V. and Daws, M. R. and Nilsson, L. N.},
  title   = {{The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway}},
  journal = {Journal of neuroinflammation},
  year    = {2017},
  doi     = {10.1186/s12974-017-0835-4},
  pmid    = {28320424},
  url     = {https://doi.org/10.1186/s12974-017-0835-4}
}

@article{fan2017-28122877,
  author  = {Fan, Z. and Brooks, D. J. and Okello, A. and Edison, P.},
  title   = {{An early and late peak in microglial activation in Alzheimer's disease trajectory}},
  journal = {Brain : a journal of neurology},
  year    = {2017},
  doi     = {10.1093/brain/aww349},
  pmid    = {28122877},
  url     = {https://doi.org/10.1093/brain/aww349}
}

@article{heneka2017-28019679,
  author  = {Heneka, Michael T},
  title   = {{Inflammasome activation and innate immunity in Alzheimer's disease}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2017},
  doi     = {10.1111/bpa.12483},
  pmid    = {28019679},
  url     = {https://doi.org/10.1111/bpa.12483}
}

@article{williams2017-28242160,
  author  = {Williams, P. A. and Marsh-Armstrong, N. and Howell, G. R. and {Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants}},
  title   = {{Neuroinflammation in glaucoma: A new opportunity}},
  journal = {Experimental eye research},
  year    = {2017},
  doi     = {10.1016/j.exer.2017.02.014},
  pmid    = {28242160},
  url     = {https://doi.org/10.1016/j.exer.2017.02.014}
}

@article{zhong2017-28209725,
  author  = {Zhong, L. and Chen, X. F. and Wang, T. and Wang, Z. and Liao, C. and Huang, R. and Wang, D. and others},
  title   = {{Soluble TREM2 induces inflammatory responses and enhances microglial survival}},
  journal = {The Journal of experimental medicine},
  year    = {2017},
  doi     = {10.1084/jem.20160844},
  pmid    = {28209725},
  url     = {https://doi.org/10.1084/jem.20160844}
}

@article{brendel2017-28197095,
  author  = {Brendel, M. and Kleinberger, G. and Probst, F. and Jaworska, A. and Overhoff, F. and Blume, T. and Albert, N. L. and Carlsen, J. and others},
  title   = {{Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00008},
  pmid    = {28197095},
  url     = {https://doi.org/10.3389/fnagi.2017.00008}
}

@article{dardiotis2017-28214109,
  author  = {Dardiotis, E. and Siokas, V. and Pantazi, E. and Dardioti, M. and Rikos, D. and Xiromerisiou, G. and Markou, A. and Papadimitriou, D. and others},
  title   = {{A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.01.015},
  pmid    = {28214109},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.01.015}
}

@article{prinz2017-28092660,
  author  = {Prinz, M. and Priller, J.},
  title   = {{The role of peripheral immune cells in the CNS in steady state and disease}},
  journal = {Nature neuroscience},
  year    = {2017},
  doi     = {10.1038/nn.4475},
  pmid    = {28092660},
  url     = {https://doi.org/10.1038/nn.4475}
}

@article{zheng2017-28077724,
  author  = {Zheng, H. and Jia, L. and Liu, C. C. and Rong, Z. and Zhong, L. and Yang, L. and Chen, X. F. and Fryer, J. D. and others},
  title   = {{TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2459-16.2017},
  pmid    = {28077724},
  url     = {https://doi.org/10.1523/jneurosci.2459-16.2017}
}

@article{moussa2017-28086917,
  author  = {Moussa, C. and Hebron, M. and Huang, X. and Ahn, J. and Rissman, R. A. and Aisen, P. S. and Turner, R. S.},
  title   = {{Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2017},
  doi     = {10.1186/s12974-016-0779-0},
  pmid    = {28086917},
  url     = {https://doi.org/10.1186/s12974-016-0779-0}
}

@article{jay2017-28100745,
  author  = {Jay, T. R. and Hirsch, A. M. and Broihier, M. L. and Miller, C. M. and Neilson, L. E. and Ransohoff, R. M. and Lamb, B. T. and Landreth, G. E.},
  title   = {{Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2110-16.2016},
  pmid    = {28100745},
  url     = {https://doi.org/10.1523/jneurosci.2110-16.2016}
}

@article{raha2017-27662313,
  author  = {Raha, A. A. and Henderson, J. W. and Stott, SR. and Vuono, R. and Foscarin, S. and Friedland, R. P. and Zaman, S. H. and Raha-Chowdhury, R.},
  title   = {{Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160663},
  pmid    = {27662313},
  url     = {https://doi.org/10.3233/jad-160663}
}

@article{gao2017-28393702,
  author  = {Gao, Li and Jiang, Teng and Yao, Xiaoying and Yu, Ling and Yang, Xiaolan and Li, Yansheng},
  title   = {{TREM2 and the Progression of Alzheimer's Disease}},
  journal = {Current neurovascular research},
  year    = {2017},
  doi     = {10.2174/1567202614666170404165201},
  pmid    = {28393702},
  url     = {https://doi.org/10.2174/1567202614666170404165201}
}

@article{kober2016-27995897,
  author  = {Kober, D. L. and Alexander-Brett, J. M. and Karch, C. M. and Cruchaga, C. and Colonna, M. and Holtzman, M. J. and Brett, T. J.},
  title   = {{Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms}},
  journal = {eLife},
  year    = {2016},
  doi     = {10.7554/elife.20391},
  pmid    = {27995897},
  url     = {https://doi.org/10.7554/elife.20391}
}

@article{dempsey2017-28003153,
  author  = {Dempsey, C. and Rubio Araiz, A. and Bryson, K. J. and Finucane, O. and Larkin, C. and Mills, E. L. and Robertson, A. A. B. and Cooper, M. A. and others},
  title   = {{Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2017},
  doi     = {10.1016/j.bbi.2016.12.014},
  pmid    = {28003153},
  url     = {https://doi.org/10.1016/j.bbi.2016.12.014}
}

@article{carrasquillo2017-27939925,
  author  = {Carrasquillo, M. M. and Allen, M. and Burgess, J. D. and Wang, X. and Strickland, S. L. and Aryal, S. and Siuda, J. and Kachadoorian, M. L. and others},
  title   = {{A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.10.005},
  pmid    = {27939925},
  url     = {https://doi.org/10.1016/j.jalz.2016.10.005}
}

@article{han2017-27871212,
  author  = {Han, Jie and Wang, Miaomiao and Ren, Manru and Lou, Haiyan},
  title   = {{Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases}},
  journal = {The International journal of neuroscience},
  year    = {2017},
  doi     = {10.1080/00207454.2016.1264072},
  pmid    = {27871212},
  url     = {https://doi.org/10.1080/00207454.2016.1264072}
}

@article{ma2016-27887626,
  author  = {Ma, L. and Allen, M. and Sakae, N. and Ertekin-Taner, N. and Graff-Radford, N. R. and Dickson, D. W. and Younkin, S. G. and Sevlever, D.},
  title   = {{Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0137-9},
  pmid    = {27887626},
  url     = {https://doi.org/10.1186/s13024-016-0137-9}
}

@article{pennisi2017-27862176,
  author  = {Pennisi, Manuela and Crupi, Rosalia and Di Paola, Rosanna and Ontario, Maria Laura and Bella, Rita and Calabrese, Edward J and Crea, Roberto and Cuzzocrea, Salvatore and others},
  title   = {{Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease}},
  journal = {Journal of neuroscience research},
  year    = {2017},
  doi     = {10.1002/jnr.23986},
  pmid    = {27862176},
  url     = {https://doi.org/10.1002/jnr.23986}
}

@article{yin2016-27717139,
  author  = {Yin, J. and Liu, X. and He, Q. and Zhou, L. and Yuan, Z. and Zhao, S.},
  title   = {{Vps35-dependent recycling of Trem2 regulates microglial function}},
  journal = {Traffic (Copenhagen, Denmark)},
  year    = {2016},
  doi     = {10.1111/tra.12451},
  pmid    = {27717139},
  url     = {https://doi.org/10.1111/tra.12451}
}

@article{kobayashi2016-27798193,
  author  = {Kobayashi, M. and Konishi, H. and Sayo, A. and Takai, T. and Kiyama, H.},
  title   = {{TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.1238-16.2016},
  pmid    = {27798193},
  url     = {https://doi.org/10.1523/jneurosci.1238-16.2016}
}

@article{sayan2016-27650313,
  author  = {Sayan, M. and Mossman, B. T.},
  title   = {{The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases}},
  journal = {Particle and fibre toxicology},
  year    = {2016},
  doi     = {10.1186/s12989-016-0162-4},
  pmid    = {27650313},
  url     = {https://doi.org/10.1186/s12989-016-0162-4}
}

@article{sirkis2016-27589997,
  author  = {Sirkis, D. W. and Bonham, L. W. and Aparicio, R. E. and Geier, E. G. and Ramos, E. M. and Wang, Q. and Karydas, A. and Miller, Z. A. and others},
  title   = {{Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression}},
  journal = {Acta neuropathologica communications},
  year    = {2016},
  doi     = {10.1186/s40478-016-0367-7},
  pmid    = {27589997},
  url     = {https://doi.org/10.1186/s40478-016-0367-7}
}

@article{xiang2016-27402340,
  author  = {Xiang, X. and Werner, G. and Bohrmann, B. and Liesz, A. and Mazaheri, F. and Capell, A. and Feederle, R. and Knuesel, I. and others},
  title   = {{TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201606370},
  pmid    = {27402340},
  url     = {https://doi.org/10.15252/emmm.201606370}
}

@article{daniels2016-27509875,
  author  = {Daniels, M. J. and Rivers-Auty, J. and Schilling, T. and Spencer, N. G. and Watremez, W. and Fasolino, V. and Booth, S. J. and White, C. S. and others},
  title   = {{Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models}},
  journal = {Nature communications},
  year    = {2016},
  doi     = {10.1038/ncomms12504},
  pmid    = {27509875},
  url     = {https://doi.org/10.1038/ncomms12504}
}

@article{song2017-27520774,
  author  = {Song, W. and Hooli, B. and Mullin, K. and Jin, S. C. and Cella, M. and Ulland, T. K. and Wang, Y. and Tanzi, R. E. and others},
  title   = {{Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.07.004},
  pmid    = {27520774},
  url     = {https://doi.org/10.1016/j.jalz.2016.07.004}
}

@article{smith2016-27522519,
  author  = {Smith, A. R. and Smith, R. G. and Condliffe, D. and Hannon, E. and Schalkwyk, L. and Mill, J. and Lunnon, K.},
  title   = {{Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.07.008},
  pmid    = {27522519},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.07.008}
}

@article{gispert2016-27423963,
  author  = {Gispert, J. D. and Suárez-Calvet, M. and Monté, G. C. and Tucholka, A. and Falcon, C. and Rojas, S. and Rami, L. and Sánchez-Valle, R. and others},
  title   = {{Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.06.005},
  pmid    = {27423963},
  url     = {https://doi.org/10.1016/j.jalz.2016.06.005}
}

@article{yeh2016-27477018,
  author  = {Yeh, F. L. and Wang, Y. and Tom, I. and Gonzalez, L. C. and Sheng, M.},
  title   = {{TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia}},
  journal = {Neuron},
  year    = {2016},
  doi     = {10.1016/j.neuron.2016.06.015},
  pmid    = {27477018},
  url     = {https://doi.org/10.1016/j.neuron.2016.06.015}
}

@article{calsolaro2016-27179961,
  author  = {Calsolaro, V. and Edison, P.},
  title   = {{Neuroinflammation in Alzheimer's disease: Current evidence and future directions}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.02.010},
  pmid    = {27179961},
  url     = {https://doi.org/10.1016/j.jalz.2016.02.010}
}

@article{suarezcalvet2016-26941262,
  author  = {Suárez-Calvet, M. and Kleinberger, G. and MÁ, Araque Caballero and Brendel, M. and Rominger, A. and Alcolea, D. and Fortea, J. and Lleó, A. and others},
  title   = {{sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201506123},
  pmid    = {26941262},
  url     = {https://doi.org/10.15252/emmm.201506123}
}

@article{yuan2016-27196974,
  author  = {Yuan, P. and Condello, C. and Keene, C. D. and Wang, Y. and Bird, T. D. and Paul, S. M. and Luo, W. and Colonna, M. and others},
  title   = {{TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy}},
  journal = {Neuron},
  year    = {2016},
  doi     = {10.1016/j.neuron.2016.05.003},
  pmid    = {27196974},
  url     = {https://doi.org/10.1016/j.neuron.2016.05.003}
}

@article{henjum2016-27121148,
  author  = {Henjum, K. and Almdahl, I. S. and Årskog, V. and Minthon, L. and Hansson, O. and Fladby, T. and Nilsson, L. N.},
  title   = {{Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2016},
  doi     = {10.1186/s13195-016-0182-1},
  pmid    = {27121148},
  url     = {https://doi.org/10.1186/s13195-016-0182-1}
}

@article{wang2016-27091843,
  author  = {Wang, Y. and Ulland, T. K. and Ulrich, J. D. and Song, W. and Tzaferis, J. A. and Hole, J. T. and Yuan, P. and Mahan, T. E. and others},
  title   = {{TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques}},
  journal = {The Journal of experimental medicine},
  year    = {2016},
  doi     = {10.1084/jem.20151948},
  pmid    = {27091843},
  url     = {https://doi.org/10.1084/jem.20151948}
}

@article{celarain2016-27051467,
  author  = {Celarain, N. and Sánchez-Ruiz de Gordoa, J. and Zelaya, M. V. and Roldán, M. and Larumbe, R. and Pulido, L. and Echavarri, C. and Mendioroz, M.},
  title   = {{TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus}},
  journal = {Clinical epigenetics},
  year    = {2016},
  doi     = {10.1186/s13148-016-0202-9},
  pmid    = {27051467},
  url     = {https://doi.org/10.1186/s13148-016-0202-9}
}

@article{rothaug2016-27016501,
  author  = {Rothaug, M. and Becker-Pauly, C. and Rose-John, S.},
  title   = {{The role of interleukin-6 signaling in nervous tissue}},
  journal = {Biochimica et biophysica acta},
  year    = {2016},
  doi     = {10.1016/j.bbamcr.2016.03.018},
  pmid    = {27016501},
  url     = {https://doi.org/10.1016/j.bbamcr.2016.03.018}
}

@article{zheng2016-27143430,
  author  = {Zheng, H. and Liu, C. C. and Atagi, Y. and Chen, X. F. and Jia, L. and Yang, L. and He, W. and Zhang, X. and others},
  title   = {{Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.03.004},
  pmid    = {27143430},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.03.004}
}

@article{varatharaj2017-26995317,
  author  = {Varatharaj, A. and Galea, I.},
  title   = {{The blood-brain barrier in systemic inflammation}},
  journal = {Brain, behavior, and immunity},
  year    = {2017},
  doi     = {10.1016/j.bbi.2016.03.010},
  pmid    = {26995317},
  url     = {https://doi.org/10.1016/j.bbi.2016.03.010}
}

@article{bhattacharjee2016-26949937,
  author  = {Bhattacharjee, S. and Zhao, Y. and Dua, P. and Rogaev, E. I. and Lukiw, W. J.},
  title   = {{microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration}},
  journal = {PloS one},
  year    = {2016},
  doi     = {10.1371/journal.pone.0150211},
  pmid    = {26949937},
  url     = {https://doi.org/10.1371/journal.pone.0150211}
}

@article{jiang2016-27067662,
  author  = {Jiang, T. and Tan, L. and Chen, Q. and Tan, M. S. and Zhou, J. S. and Zhu, X. C. and Lu, H. and Wang, H. F. and others},
  title   = {{A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.02.023},
  pmid    = {27067662},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.02.023}
}

@article{saresella2016-26939933,
  author  = {Saresella, Marina and La Rosa, Francesca and Piancone, Federica and Zoppis, Martina and Marventano, Ivana and Calabrese, Elena and Rainone, Veronica and Nemni, Raffaello and others},
  title   = {{The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0088-1},
  pmid    = {26939933},
  url     = {https://doi.org/10.1186/s13024-016-0088-1}
}

@article{spangenberg2016-26921617,
  author  = {Spangenberg, E. E. and Lee, R. J. and Najafi, A. R. and Rice, R. A. and Elmore, M. R. and Blurton-Jones, M. and West, B. L. and Green, K. N.},
  title   = {{Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology}},
  journal = {Brain : a journal of neurology},
  year    = {2016},
  doi     = {10.1093/brain/aww016},
  pmid    = {26921617},
  url     = {https://doi.org/10.1093/brain/aww016}
}

@article{colonna2016-26911435,
  author  = {Colonna, M. and Wang, Y.},
  title   = {{TREM2 variants: new keys to decipher Alzheimer disease pathogenesis}},
  journal = {Nature reviews. Neuroscience},
  year    = {2016},
  doi     = {10.1038/nrn.2016.7},
  pmid    = {26911435},
  url     = {https://doi.org/10.1038/nrn.2016.7}
}

@article{ulrich2016-26854967,
  author  = {Ulrich, J. D. and Holtzman, D. M.},
  title   = {{TREM2 Function in Alzheimer's Disease and Neurodegeneration}},
  journal = {ACS chemical neuroscience},
  year    = {2016},
  doi     = {10.1021/acschemneuro.5b00313},
  pmid    = {26854967},
  url     = {https://doi.org/10.1021/acschemneuro.5b00313}
}

@article{jiang2016-26802771,
  author  = {Jiang, T. and Zhang, Y. D. and Chen, Q. and Gao, Q. and Zhu, X. C. and Zhou, J. S. and Shi, J. Q. and Lu, H. and others},
  title   = {{TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice}},
  journal = {Neuropharmacology},
  year    = {2016},
  doi     = {10.1016/j.neuropharm.2016.01.028},
  pmid    = {26802771},
  url     = {https://doi.org/10.1016/j.neuropharm.2016.01.028}
}

@article{glebov2016-26792193,
  author  = {Glebov, Konstantin and Wunderlich, Patrick and Karaca, Ilker and Walter, Jochen},
  title   = {{Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)}},
  journal = {Journal of neuroinflammation},
  year    = {2016},
  doi     = {10.1186/s12974-016-0479-9},
  pmid    = {26792193},
  url     = {https://doi.org/10.1186/s12974-016-0479-9}
}

@article{jiang2017-26780455,
  author  = {Jiang, Teng and Wan, Yu and Zhang, Ying-Dong and Zhou, Jun-Shan and Gao, Qing and Zhu, Xi-Chen and Shi, Jian-Quan and Lu, Huan and others},
  title   = {{TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice}},
  journal = {Molecular neurobiology},
  year    = {2017},
  doi     = {10.1007/s12035-016-9704-x},
  pmid    = {26780455},
  url     = {https://doi.org/10.1007/s12035-016-9704-x}
}

@article{lian2016-26758846,
  author  = {Lian, Hong and Litvinchuk, Alexandra and Chiang, Angie C.A. and Aithmitti, Nadia and Jankowsky, Joanna L. and Zheng, Hui},
  title   = {{Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease}},
  journal = {Journal of Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.2117-15.2016},
  pmid    = {26758846},
  url     = {https://doi.org/10.1523/jneurosci.2117-15.2016}
}

@article{heslegrave2016-26754172,
  author  = {Heslegrave, A. and Heywood, W. and Paterson, R. and Magdalinou, N. and Svensson, J. and Johansson, P. and Öhrfelt, A. and Blennow, K. and others},
  title   = {{Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0071-x},
  pmid    = {26754172},
  url     = {https://doi.org/10.1186/s13024-016-0071-x}
}

@article{piccio2016-26754641,
  author  = {Piccio, L. and Deming, Y. and Del-Águila, J. L. and Ghezzi, L. and Holtzman, D. M. and Fagan, A. M. and Fenoglio, C. and Galimberti, D. and others},
  title   = {{Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-016-1533-5},
  pmid    = {26754641},
  url     = {https://doi.org/10.1007/s00401-016-1533-5}
}

@article{ohrfelt2016-26754805,
  author  = {Öhrfelt, A. and Axelsson, M. and Malmeström, C. and Novakova, L. and Heslegrave, A. and Blennow, K. and Lycke, J. and Zetterberg, H.},
  title   = {{Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone}},
  journal = {Multiple sclerosis (Houndmills, Basingstoke, England)},
  year    = {2016},
  doi     = {10.1177/1352458515624558},
  pmid    = {26754805},
  url     = {https://doi.org/10.1177/1352458515624558}
}

@article{melah2016-26836182,
  author  = {Melah, K. E. and Lu, S. Y. and Hoscheidt, S. M. and Alexander, A. L. and Adluru, N. and Destiche, D. J. and Carlsson, C. M. and Zetterberg, H. and others},
  title   = {{Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2016},
  doi     = {10.3233/jad-150897},
  pmid    = {26836182},
  url     = {https://doi.org/10.3233/jad-150897}
}

@article{wang2016-26506595,
  author  = {Wang, X. Q. and Tao, B. B. and Li, B. and Wang, X. H. and Zhang, W. C. and Wan, L. and Hua, X. M. and Li, S. T.},
  title   = {{Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma}},
  journal = {Oncotarget},
  year    = {2016},
  doi     = {10.18632/oncotarget.6221},
  pmid    = {26506595},
  url     = {https://doi.org/10.18632/oncotarget.6221}
}

@article{jiang2016-27501831,
  author  = {Jiang, T. and Hou, J. K. and Gao, Q. and Yu, J. T. and Zhou, J. S. and Zhao, H. D. and Zhang, Y. D.},
  title   = {{TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects}},
  journal = {Current neurovascular research},
  year    = {2016},
  doi     = {10.2174/1567202613666160808095530},
  pmid    = {27501831},
  url     = {https://doi.org/10.2174/1567202613666160808095530}
}

@article{hong2016-26745839,
  author  = {Hong, S. and Dissing-Olesen, L. and Stevens, B.},
  title   = {{New insights on the role of microglia in synaptic pruning in health and disease}},
  journal = {Current opinion in neurobiology},
  year    = {2016},
  doi     = {10.1016/j.conb.2015.12.004},
  pmid    = {26745839},
  url     = {https://doi.org/10.1016/j.conb.2015.12.004}
}

@article{brites2015-26733805,
  author  = {Brites, D. and Fernandes, A.},
  title   = {{Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2015},
  doi     = {10.3389/fncel.2015.00476},
  pmid    = {26733805},
  url     = {https://doi.org/10.3389/fncel.2015.00476}
}

@article{pekny2016-26671410,
  author  = {Pekny, M. and Pekna, M. and Messing, A. and Steinhäuser, C. and Lee, J. M. and Parpura, V. and Hol, E. M. and Sofroniew, M. V. and others},
  title   = {{Astrocytes: a central element in neurological diseases}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-015-1513-1},
  pmid    = {26671410},
  url     = {https://doi.org/10.1007/s00401-015-1513-1}
}

@article{yirmiya2015-26442697,
  author  = {Yirmiya, R. and Rimmerman, N. and Reshef, R.},
  title   = {{Depression as a microglial disease}},
  journal = {Trends in neurosciences},
  year    = {2015},
  doi     = {10.1016/j.tins.2015.08.001},
  pmid    = {26442697},
  url     = {https://doi.org/10.1016/j.tins.2015.08.001}
}

@article{chan2015-26414614,
  author  = {Chan, G. and White, C. C. and Winn, P. A. and Cimpean, M. and Replogle, J. M. and Glick, L. R. and Cuerdon, N. E. and Ryan, K. J. and others},
  title   = {{CD33 modulates TREM2: convergence of Alzheimer loci}},
  journal = {Nature neuroscience},
  year    = {2015},
  doi     = {10.1038/nn.4126},
  pmid    = {26414614},
  url     = {https://doi.org/10.1038/nn.4126}
}

@article{atagi2015-26374899,
  author  = {Atagi, Y. and Liu, C. C. and Painter, M. M. and Chen, X. F. and Verbeeck, C. and Zheng, H. and Li, X. and Rademakers, R. and others},
  title   = {{Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.679043},
  pmid    = {26374899},
  url     = {https://doi.org/10.1074/jbc.m115.679043}
}

@article{liu2016-26365049,
  author  = {Liu, G. and Liu, Y. and Jiang, Q. and Jiang, Y. and Feng, R. and Zhang, L. and Chen, Z. and Li, K. and others},
  title   = {{Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility}},
  journal = {Molecular neurobiology},
  year    = {2016},
  doi     = {10.1007/s12035-015-9416-7},
  pmid    = {26365049},
  url     = {https://doi.org/10.1007/s12035-015-9416-7}
}

@article{painter2015-26337043,
  author  = {Painter, M. M. and Atagi, Y. and Liu, C. C. and Rademakers, R. and Xu, H. and Fryer, J. D. and Bu, G.},
  title   = {{TREM2 in CNS homeostasis and neurodegenerative disease}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0040-9},
  pmid    = {26337043},
  url     = {https://doi.org/10.1186/s13024-015-0040-9}
}

@article{huang2015-25852195,
  author  = {Huang, M. and Wang, D. and Xu, Z. and Xu, Y. and Xu, X. and Ma, Y. and Xia, Z.},
  title   = {{Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2015},
  doi     = {10.1177/1533317515577128},
  pmid    = {25852195},
  url     = {https://doi.org/10.1177/1533317515577128}
}

@article{jiang2015-26364736,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhou, J. S. and Cao, L. and Tan, M. S. and Wang, H. F. and Chen, Q. and others},
  title   = {{Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2015.08.019},
  pmid    = {26364736},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.08.019}
}

@article{ramanan2015-26268530,
  author  = {Ramanan, Vijay K. and Risacher, Shannon L. and Nho, Kwangsik T. and Kim, Sungeun and Shen, Li and McDonald, Brenna C. and Yoder, Karmen K. and Hutchins, Gary D. and others},
  title   = {{GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP}},
  journal = {Brain},
  year    = {2015},
  doi     = {10.1093/brain/awv231},
  pmid    = {26268530},
  url     = {https://doi.org/10.1093/brain/awv231}
}

@article{korvatska2015-26076170,
  author  = {Korvatska, O. and Leverenz, J. B. and Jayadev, S. and McMillan, P. and Kurtz, I. and Guo, X. and Rumbaugh, M. and Matsushita, M. and others},
  title   = {{R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2015.0979},
  pmid    = {26076170},
  url     = {https://doi.org/10.1001/jamaneurol.2015.0979}
}

@article{zenaro2015-26214837,
  author  = {Zenaro, E. and Pietronigro, E. and Della Bianca, V. and Piacentino, G. and Marongiu, L. and Budui, S. and Turano, E. and Rossi, B. and others},
  title   = {{Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin}},
  journal = {Nature medicine},
  year    = {2015},
  doi     = {10.1038/nm.3913},
  pmid    = {26214837},
  url     = {https://doi.org/10.1038/nm.3913}
}

@article{lu2015-26037549,
  author  = {Lu, Y. and Liu, W. and Wang, X.},
  title   = {{TREM2 variants and risk of Alzheimer's disease: a meta-analysis}},
  journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
  year    = {2015},
  doi     = {10.1007/s10072-015-2274-2},
  pmid    = {26037549},
  url     = {https://doi.org/10.1007/s10072-015-2274-2}
}

@article{wang2015-26207229,
  author  = {Wang, W. Y. and Tan, M. S. and Yu, J. T. and Tan, L.},
  title   = {{Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease}},
  journal = {Annals of translational medicine},
  year    = {2015},
  doi     = {10.3978/j.issn.2305-5839.2015.03.49},
  pmid    = {26207229},
  url     = {https://doi.org/10.3978/j.issn.2305-5839.2015.03.49}
}

@article{zhong2015-25957402,
  author  = {Zhong, L. and Chen, X. F. and Zhang, Z. L. and Wang, Z. and Shi, X. Z. and Xu, K. and Zhang, Y. W. and Xu, H. and others},
  title   = {{DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.645986},
  pmid    = {25957402},
  url     = {https://doi.org/10.1074/jbc.m115.645986}
}

@article{bosco2015-6869bfb1,
  author  = {Bosco, Alejandra and Romero, Cesar O. and Breen, Kevin T. and Chagovetz, Alexis A. and Steele, Michael R. and Ambati, Balamurali K. and Vetter, Monica L.},
  title   = {{Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma}},
  journal = {Disease Models \& Mechanisms},
  year    = {2015},
  doi     = {10.1242/dmm.018788},
  url     = {https://doi.org/10.1242/dmm.018788}
}

@article{lill2015-25936935,
  author  = {Lill, C. M. and Rengmark, A. and Pihlstrøm, L. and Fogh, I. and Shatunov, A. and Sleiman, P. M. and Wang, L. S. and Liu, T. and others},
  title   = {{The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.12.009},
  pmid    = {25936935},
  url     = {https://doi.org/10.1016/j.jalz.2014.12.009}
}

@article{poliani2015-25893602,
  author  = {Poliani, P. L. and Wang, Y. and Fontana, E. and Robinette, M. L. and Yamanishi, Y. and Gilfillan, S. and Colonna, M.},
  title   = {{TREM2 sustains microglial expansion during aging and response to demyelination}},
  journal = {The Journal of clinical investigation},
  year    = {2015},
  doi     = {10.1172/jci77983},
  pmid    = {25893602},
  url     = {https://doi.org/10.1172/jci77983}
}

@article{jin2015-25886450,
  author  = {Jin, S. C. and Carrasquillo, M. M. and Benitez, B. A. and Skorupa, T. and Carrell, D. and Patel, D. and Lincoln, S. and Krishnan, S. and others},
  title   = {{TREM2 is associated with increased risk for Alzheimer's disease in African Americans}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0016-9},
  pmid    = {25886450},
  url     = {https://doi.org/10.1186/s13024-015-0016-9}
}

@article{savage2015-25904803,
  author  = {Savage, J. C. and Jay, T. and Goduni, E. and Quigley, C. and Mariani, M. M. and Malm, T. and Ransohoff, R. M. and Lamb, B. T. and others},
  title   = {{Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.4586-14.2015},
  pmid    = {25904803},
  url     = {https://doi.org/10.1523/jneurosci.4586-14.2015}
}

@article{maphis2015-25833819,
  author  = {Maphis, Nicole M. and Xu, Guixiang and Kokiko‐Cochran, Olga N. and Jiang, Shanya and Cardona, Astrid E. and Ransohoff, Richard M. and Lamb, Bruce T. and Bhaskar, Kiran},
  title   = {{Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain}},
  journal = {Brain},
  year    = {2015},
  doi     = {10.1093/brain/awv081},
  pmid    = {25833819},
  url     = {https://doi.org/10.1093/brain/awv081}
}

@article{xing2015-26478868,
  author  = {Xing, J. and Titus, A. R. and Humphrey, M. B.},
  title   = {{The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective}},
  journal = {Research and reports in biochemistry},
  year    = {2015},
  doi     = {10.2147/rrbc.s58057},
  pmid    = {26478868},
  url     = {https://doi.org/10.2147/rrbc.s58057}
}

@article{matsuda2015-ebf754c6,
  author  = {Matsuda, Taito and Murao, Naoya and Katano, Yuki and Juliandi, Berry and Kohyama, Jun and Akira, Shizuo and Kawai, Taro and Nakashima, Kinichi},
  title   = {{TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus}},
  journal = {Nature Communications},
  year    = {2015},
  doi     = {10.1038/ncomms7514},
  url     = {https://doi.org/10.1038/ncomms7514}
}

@article{kamphuis2015-ea259c45,
  author  = {Kamphuis, Willem and Kooijman, Lieneke and Orre, Marie and Stassen, Oscar and Pekny, Milos and Hol, Elly M.},
  title   = {{GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for A lzheimer's disease}},
  journal = {Glia},
  year    = {2015},
  doi     = {10.1002/glia.22800},
  url     = {https://doi.org/10.1002/glia.22800}
}

@article{jay2015-25732305,
  author  = {Jay, T. R. and Miller, C. M. and Cheng, P. J. and Graham, L. C. and Bemiller, S. and Broihier, M. L. and Xu, G. and Margevicius, D. and others},
  title   = {{TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models}},
  journal = {The Journal of experimental medicine},
  year    = {2015},
  doi     = {10.1084/jem.20142322},
  pmid    = {25732305},
  url     = {https://doi.org/10.1084/jem.20142322}
}

@article{replogle2015-25545807,
  author  = {Replogle, J. M. and Chan, G. and White, C. C. and Raj, T. and Winn, P. A. and Evans, D. A. and Sperling, R. A. and Chibnik, L. B. and others},
  title   = {{A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24337},
  pmid    = {25545807},
  url     = {https://doi.org/10.1002/ana.24337}
}

@article{heneka2015-25689443,
  author  = {Heneka, M. T. and Golenbock, D. T. and Latz, E.},
  title   = {{Innate immunity in Alzheimer's disease}},
  journal = {Nature immunology},
  year    = {2015},
  doi     = {10.1038/ni.3102},
  pmid    = {25689443},
  url     = {https://doi.org/10.1038/ni.3102}
}

@article{zhu2015-25816748,
  author  = {Zhu, Caihong and Herrmann, Uli S and Li, Bei and Abakumova, Irina and Moos, Rita and Schwarz, Petra and Rushing, Elisabeth J and Colonna, Marco and others},
  title   = {{Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2015.02.019},
  pmid    = {25816748},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.02.019}
}

@article{wang2015-25728668,
  author  = {Wang, Y. and Cella, M. and Mallinson, K. and Ulrich, J. D. and Young, K. L. and Robinette, M. L. and Gilfillan, S. and Krishnan, G. M. and others},
  title   = {{TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model}},
  journal = {Cell},
  year    = {2015},
  doi     = {10.1016/j.cell.2015.01.049},
  pmid    = {25728668},
  url     = {https://doi.org/10.1016/j.cell.2015.01.049}
}

@article{brown2015-602808b8,
  author  = {Brown, Amanda},
  title   = {{Understanding the MIND phenotype: macrophage/microglia inflammation in neurocognitive disorders related to human immunodeficiency virus infection}},
  journal = {Clinical and Translational Medicine},
  year    = {2015},
  doi     = {10.1186/s40169-015-0049-2},
  url     = {https://doi.org/10.1186/s40169-015-0049-2}
}

@article{park2015-25615530,
  author  = {Park, J. S. and Ji, I. J. and An, H. J. and Kang, M. J. and Kang, S. W. and Kim, D. H. and Yoon, S. Y.},
  title   = {{Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus}},
  journal = {Traffic (Copenhagen, Denmark)},
  year    = {2015},
  doi     = {10.1111/tra.12264},
  pmid    = {25615530},
  url     = {https://doi.org/10.1111/tra.12264}
}

@article{kim2015-25690731,
  author  = {Kim, E. K. and Choi, E. J.},
  title   = {{Compromised MAPK signaling in human diseases: an update}},
  journal = {Archives of toxicology},
  year    = {2015},
  doi     = {10.1007/s00204-015-1472-2},
  pmid    = {25690731},
  url     = {https://doi.org/10.1007/s00204-015-1472-2}
}

@article{li2015-7e58f8dc,
  author  = {Li, Matthew D. and Burns, Terry C. and Kumar, Sunny and Morgan, Alexander A. and Sloan, Steven A. and Palmer, Theo D.},
  title   = {{Aging‐like changes in the transcriptome of irradiated microglia}},
  journal = {Glia},
  year    = {2015},
  doi     = {10.1002/glia.22782},
  url     = {https://doi.org/10.1002/glia.22782}
}

@article{biesmans2015-5f2cd130,
  author  = {Biesmans, Steven and Acton, Paul D. and Cotto, Carlos and Langlois, Xavier and Donck, Luc Ver and Bouwknecht, Jan A. and Aelvoet, Sarah‐Ann and Hellings, Niels and others},
  title   = {{Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap‐luc mice}},
  journal = {Glia},
  year    = {2015},
  doi     = {10.1002/glia.22804},
  url     = {https://doi.org/10.1002/glia.22804}
}

@article{carretrebillat2015-79617690,
  author  = {Carret-Rebillat, Anne-Sophie and Pace, Clarisse and Gourmaud, Sarah and Ravasi, Laura and Montagne-Stora, Samantha and Longueville, Sophie and Tible, Marion and Sudol, Erika and others},
  title   = {{Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation}},
  journal = {Scientific Reports},
  year    = {2015},
  doi     = {10.1038/srep08489},
  url     = {https://doi.org/10.1038/srep08489}
}

@article{coll2015-25686105,
  author  = {Coll, R. C. and Robertson, A. A. and Chae, J. J. and Higgins, S. C. and Muñoz-Planillo, R. and Inserra, M. C. and Vetter, I. and Dungan, L. S. and others},
  title   = {{A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases}},
  journal = {Nature medicine},
  year    = {2015},
  doi     = {10.1038/nm.3806},
  pmid    = {25686105},
  url     = {https://doi.org/10.1038/nm.3806}
}

@article{carroll2015-a3cc5d37,
  author  = {Carroll, James A. and Striebel, James F. and Race, Brent and Phillips, Katie and Chesebro, Bruce},
  title   = {{Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction}},
  journal = {Journal of Virology},
  year    = {2015},
  doi     = {10.1128/jvi.02952-14},
  url     = {https://doi.org/10.1128/jvi.02952-14}
}

@article{haim2015-fb6262b5,
  author  = {Haim, Lucile Ben and Ceyzériat, Kelly and Sauvage, Maria Angeles Carrillo-de and Aubry, Fabien and Auregan, Gwennaëlle and Guillermier, Martine and Ruiz, Marta and Petit, Fanny and others},
  title   = {{The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases}},
  journal = {The Journal of Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.3516-14.2015},
  url     = {https://doi.org/10.1523/jneurosci.3516-14.2015}
}

@article{kawabori2015-25716838,
  author  = {Kawabori, M. and Kacimi, R. and Kauppinen, T. and Calosing, C. and Kim, J. Y. and Hsieh, C. L. and Nakamura, M. C. and Yenari, M. A.},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.2620-14.2015},
  pmid    = {25716838},
  url     = {https://doi.org/10.1523/jneurosci.2620-14.2015}
}

@article{cantoni2015-25631124,
  author  = {Cantoni, C. and Bollman, B. and Licastro, D. and Xie, M. and Mikesell, R. and Schmidt, R. and Yuede, C. M. and Galimberti, D. and others},
  title   = {{TREM2 regulates microglial cell activation in response to demyelination in vivo}},
  journal = {Acta neuropathologica},
  year    = {2015},
  doi     = {10.1007/s00401-015-1388-1},
  pmid    = {25631124},
  url     = {https://doi.org/10.1007/s00401-015-1388-1}
}

@article{cox2015-0d3a0b26,
  author  = {Cox, Donal J. and Field, Robert H. and Williams, David G. and Baran, Marcin and Bowie, Andrew G. and Cunningham, Colm and Dunne, Aisling},
  title   = {{DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease}},
  journal = {Glia},
  year    = {2015},
  doi     = {10.1002/glia.22786},
  url     = {https://doi.org/10.1002/glia.22786}
}

@article{matarin2015-25620700,
  author  = {Matarin, M. and Salih, D. A. and Yasvoina, M. and Cummings, D. M. and Guelfi, S. and Liu, W. and Nahaboo Solim, M. A. and Moens, T. G. and others},
  title   = {{A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology}},
  journal = {Cell reports},
  year    = {2015},
  doi     = {10.1016/j.celrep.2014.12.041},
  pmid    = {25620700},
  url     = {https://doi.org/10.1016/j.celrep.2014.12.041}
}

@article{levy2015-4d2d615e,
  author  = {Levy, Olivier and Calippe, Bertrand and Lavalette, Sophie and Hu, Shulong J and Raoul, William and Dominguez, Elisa and Housset, Michael and Paques, Michel and others},
  title   = {{Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration}},
  journal = {EMBO Molecular Medicine},
  year    = {2015},
  doi     = {10.15252/emmm.201404524},
  url     = {https://doi.org/10.15252/emmm.201404524}
}

@article{tang2016-25598354,
  author  = {Tang, Y. and Le, W.},
  title   = {{Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases}},
  journal = {Molecular neurobiology},
  year    = {2016},
  doi     = {10.1007/s12035-014-9070-5},
  pmid    = {25598354},
  url     = {https://doi.org/10.1007/s12035-014-9070-5}
}

@article{li2015-25593125,
  author  = {Li, Xianwu and Montine, Kathleen S and Keene, C Dirk and Montine, Thomas J},
  title   = {{Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2015},
  doi     = {10.1096/fj.14-262683},
  pmid    = {25593125},
  url     = {https://doi.org/10.1096/fj.14-262683}
}

@article{elhage2015-84bbe974,
  author  = {El-Hage, Nazira and Rodriguez, Myosotys and Dever, Seth M. and Masvekar, Ruturaj R. and Gewirtz, David A. and Shacka, John J.},
  title   = {{HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse}},
  journal = {Journal of Virology},
  year    = {2015},
  doi     = {10.1128/jvi.02022-14},
  url     = {https://doi.org/10.1128/jvi.02022-14}
}

@article{cho2015-e082a2d8,
  author  = {Cho, Seo-Hyun and Chen, Jason A. and Sayed, Faten and Ward, Michael E. and Gao, Fuying and Nguyen, Thi A. and Krabbe, Grietje and Sohn, Peter Dongmin and others},
  title   = {{SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β}},
  journal = {The Journal of Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.2939-14.2015},
  url     = {https://doi.org/10.1523/jneurosci.2939-14.2015}
}

@article{lian2015-25533482,
  author  = {Lian, H. and Yang, L. and Cole, A. and Sun, L. and Chiang, A. C. and Fowler, S. W. and Shim, D. J. and Rodriguez-Rivera, J. and others},
  title   = {{NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease}},
  journal = {Neuron},
  year    = {2015},
  doi     = {10.1016/j.neuron.2014.11.018},
  pmid    = {25533482},
  url     = {https://doi.org/10.1016/j.neuron.2014.11.018}
}

@article{roussos2015-25499537,
  author  = {Roussos, P. and Katsel, P. and Fam, P. and Tan, W. and Purohit, D. P. and Haroutunian, V.},
  title   = {{The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.10.013},
  pmid    = {25499537},
  url     = {https://doi.org/10.1016/j.jalz.2014.10.013}
}

@article{lue2015-25186950,
  author  = {Lue, L. F. and Schmitz, C. T. and Serrano, G. and Sue, L. I. and Beach, T. G. and Walker, D. G.},
  title   = {{TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2015},
  doi     = {10.1111/bpa.12190},
  pmid    = {25186950},
  url     = {https://doi.org/10.1111/bpa.12190}
}

@article{lue2015-25281879,
  author  = {Lue, L. F. and Schmitz, C. and Walker, D. G.},
  title   = {{What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?}},
  journal = {Neuroscience},
  year    = {2015},
  doi     = {10.1016/j.neuroscience.2014.09.050},
  pmid    = {25281879},
  url     = {https://doi.org/10.1016/j.neuroscience.2014.09.050}
}

@article{hooli2014-25186855,
  author  = {Hooli, B. V. and Parrado, A. R. and Mullin, K. and Yip, W. K. and Liu, T. and Roehr, J. T. and Qiao, D. and Jessen, F. and others},
  title   = {{The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000855},
  pmid    = {25186855},
  url     = {https://doi.org/10.1212/wnl.0000000000000855}
}

@article{slattery2014-25160042,
  author  = {Slattery, C. F. and Beck, J. A. and Harper, L. and Adamson, G. and Abdi, Z. and Uphill, J. and Campbell, T. and Druyeh, R. and others},
  title   = {{R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2014},
  doi     = {10.1016/j.jalz.2014.05.1751},
  pmid    = {25160042},
  url     = {https://doi.org/10.1016/j.jalz.2014.05.1751}
}

@article{park2015-25114293,
  author  = {Park, M. and Yi, J. W. and Kim, E. M. and Yoon, I. J. and Lee, E. H. and Lee, H. Y. and Ji, K. Y. and Lee, K. H. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity}},
  journal = {Diabetes},
  year    = {2015},
  doi     = {10.2337/db13-1869},
  pmid    = {25114293},
  url     = {https://doi.org/10.2337/db13-1869}
}

@article{jiang2014-25047746,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhang, Q. Q. and Cao, L. and Tan, M. S. and Gu, L. Z. and Wang, H. F. and others},
  title   = {{Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2014},
  doi     = {10.1038/npp.2014.164},
  pmid    = {25047746},
  url     = {https://doi.org/10.1038/npp.2014.164}
}

@article{kleinberger2014-24990881,
  author  = {Kleinberger, G. and Yamanishi, Y. and Suárez-Calvet, M. and Czirr, E. and Lohmann, E. and Cuyvers, E. and Struyfs, H. and Pettkus, N. and others},
  title   = {{TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis}},
  journal = {Science translational medicine},
  year    = {2014},
  doi     = {10.1126/scitranslmed.3009093},
  pmid    = {24990881},
  url     = {https://doi.org/10.1126/scitranslmed.3009093}
}

@article{jin2014-24899047,
  author  = {Jin, S. C. and Benitez, B. A. and Karch, C. M. and Cooper, B. and Skorupa, T. and Carrell, D. and Norton, J. B. and Hsu, S. and others},
  title   = {{Coding variants in TREM2 increase risk for Alzheimer's disease}},
  journal = {Human molecular genetics},
  year    = {2014},
  doi     = {10.1093/hmg/ddu277},
  pmid    = {24899047},
  url     = {https://doi.org/10.1093/hmg/ddu277}
}

@article{ulrich2014-24893973,
  author  = {Ulrich, J. D. and Finn, M. B. and Wang, Y. and Shen, A. and Mahan, T. E. and Jiang, H. and Stewart, F. R. and Piccio, L. and others},
  title   = {{Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2014},
  doi     = {10.1186/1750-1326-9-20},
  pmid    = {24893973},
  url     = {https://doi.org/10.1186/1750-1326-9-20}
}

@article{jiao2014-24866402,
  author  = {Jiao, B. and Liu, X. and Tang, B. and Hou, L. and Zhou, L. and Zhang, F. and Zhou, Y. and Guo, J. and others},
  title   = {{Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.04.025},
  pmid    = {24866402},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.04.025}
}

@article{leber2014-24910390,
  author  = {Le Ber, I. and De Septenville, A. and Guerreiro, R. and Bras, J. and Camuzat, A. and Caroppo, P. and Lattante, S. and Couarch, P. and others},
  title   = {{Homozygous TREM2 mutation in a family with atypical frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.04.010},
  pmid    = {24910390},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.04.010}
}

@article{cady2014-24535663,
  author  = {Cady, J. and Koval, E. D. and Benitez, B. A. and Zaidman, C. and Jockel-Balsarotti, J. and Allred, P. and Baloh, R. H. and Ravits, J. and others},
  title   = {{TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.6237},
  pmid    = {24535663},
  url     = {https://doi.org/10.1001/jamaneurol.2013.6237}
}

@article{pekny2014-24406153,
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  title   = {{The dual role of astrocyte activation and reactive gliosis}},
  journal = {Neuroscience letters},
  year    = {2014},
  doi     = {10.1016/j.neulet.2013.12.071},
  pmid    = {24406153},
  url     = {https://doi.org/10.1016/j.neulet.2013.12.071}
}

@article{hu2014-24002183,
  author  = {Hu, N. and Tan, M. S. and Yu, J. T. and Sun, L. and Tan, L. and Wang, Y. L. and Jiang, T.},
  title   = {{Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-130854},
  pmid    = {24002183},
  url     = {https://doi.org/10.3233/jad-130854}
}

@article{miyashita2014-24762945,
  author  = {Miyashita, A. and Wen, Y. and Kitamura, N. and Matsubara, E. and Kawarabayashi, T. and Shoji, M. and Tomita, N. and Furukawa, K. and others},
  title   = {{Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-140225},
  pmid    = {24762945},
  url     = {https://doi.org/10.3233/jad-140225}
}

@article{benitez2014-24439484,
  author  = {Benitez, B. A. and Jin, S. C. and Guerreiro, R. and Graham, R. and Lord, J. and Harold, D. and Sims, R. and Lambert, J. C. and others},
  title   = {{Missense variant in TREML2 protects against Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.12.010},
  pmid    = {24439484},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.12.010}
}

@article{hickman2014-24355566,
  author  = {Hickman, S. E. and El Khoury, J.},
  title   = {{TREM2 and the neuroimmunology of Alzheimer's disease}},
  journal = {Biochemical pharmacology},
  year    = {2014},
  doi     = {10.1016/j.bcp.2013.11.021},
  pmid    = {24355566},
  url     = {https://doi.org/10.1016/j.bcp.2013.11.021}
}

@article{borroni2014-24139279,
  author  = {Borroni, B. and Ferrari, F. and Galimberti, D. and Nacmias, B. and Barone, C. and Bagnoli, S. and Fenoglio, C. and Piaceri, I. and others},
  title   = {{Heterozygous TREM2 mutations in frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.09.017},
  pmid    = {24139279},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.09.017}
}

@article{reitz2013-1f8a1527,
  author  = {Reitz, Christiane and Mayeux, Richard P},
  title   = {{TREM2 and Neurodegenerative Disease}},
  journal = {New England Journal of Medicine},
  year    = {2013},
  doi     = {10.1056/nejmc1306509},
  url     = {https://doi.org/10.1056/nejmc1306509}
}

@article{yu2014-24184202,
  author  = {Yu, J. T. and Jiang, T. and Wang, Y. L. and Wang, H. F. and Zhang, W. and Hu, N. and Tan, L. and Sun, L. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.10.075},
  pmid    = {24184202},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.10.075}
}

@article{cuyvers2014-24119542,
  author  = {Cuyvers, E. and Bettens, K. and Philtjens, S. and Van Langenhove, T. and Gijselinck, I. and van der Zee, J. and Engelborghs, S. and Vandenbulcke, M. and others},
  title   = {{Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.09.009},
  pmid    = {24119542},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.09.009}
}

@article{wunderlich2013-24078628,
  author  = {Wunderlich, P. and Glebov, K. and Kemmerling, N. and Tien, N. T. and Neumann, H. and Walter, J.},
  title   = {{Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m113.517540},
  pmid    = {24078628},
  url     = {https://doi.org/10.1074/jbc.m113.517540}
}

@article{ruiz2014-24041969,
  author  = {Ruiz, A. and Dols-Icardo, O. and Bullido, M. J. and Pastor, P. and Rodríguez-Rodríguez, E. and López de Munain, A. and de Pancorbo, M. M. and Pérez-Tur, J. and others},
  title   = {{Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.08.011},
  pmid    = {24041969},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.08.011}
}

@article{schott2013-23983027,
  author  = {Schott, Jonathan M. and Révész, Tamás},
  title   = {{Inflammation in Alzheimer’s disease: insights from immunotherapy}},
  journal = {Brain},
  year    = {2013},
  doi     = {10.1093/brain/awt231},
  pmid    = {23983027},
  url     = {https://doi.org/10.1093/brain/awt231}
}

@article{guerreiro2013-23870839,
  author  = {Guerreiro, R. and Bilgic, B. and Guven, G. and Brás, J. and Rohrer, J. and Lohmann, E. and Hanagasi, H. and Gurvit, H. and others},
  title   = {{Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.06.005},
  pmid    = {23870839},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.06.005}
}

@article{forabosco2013-23855984,
  author  = {Forabosco, P. and Ramasamy, A. and Trabzuni, D. and Walker, R. and Smith, C. and Bras, J. and Levine, A. P. and Hardy, J. and others},
  title   = {{Insights into TREM2 biology by network analysis of human brain gene expression data}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.05.001},
  pmid    = {23855984},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.05.001}
}

@article{chiu2013-23850290,
  author  = {Chiu, Isaac M. and Morimoto, Emiko and Goodarzi, Hani and Liao, Jennifer T. and O’Keeffe, Sean and Phatnani, Hemali P. and Muratet, Michael A. and Carroll, Michael C. and others},
  title   = {{A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model}},
  journal = {Cell Reports},
  year    = {2013},
  doi     = {10.1016/j.celrep.2013.06.018},
  pmid    = {23850290},
  url     = {https://doi.org/10.1016/j.celrep.2013.06.018}
}

@article{sheedy2013-23812099,
  author  = {Sheedy, F. J. and Grebe, A. and Rayner, K. J. and Kalantari, P. and Ramkhelawon, B. and Carpenter, S. B. and Becker, C. E. and others},
  title   = {{CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation}},
  journal = {Nature immunology},
  year    = {2013},
  doi     = {10.1038/ni.2639},
  pmid    = {23812099},
  url     = {https://doi.org/10.1038/ni.2639}
}

@article{rayaprolu2013-23800361,
  author  = {Rayaprolu, S. and Mullen, B. and Baker, M. and Lynch, T. and Finger, E. and Seeley, W. W. and Hatanpaa, K. J. and Lomen-Hoerth, C. and others},
  title   = {{TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2013},
  doi     = {10.1186/1750-1326-8-19},
  pmid    = {23800361},
  url     = {https://doi.org/10.1186/1750-1326-8-19}
}

@article{waschek2013-23517078,
  author  = {Waschek, J. A.},
  title   = {{VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair}},
  journal = {British journal of pharmacology},
  year    = {2013},
  doi     = {10.1111/bph.12181},
  pmid    = {23517078},
  url     = {https://doi.org/10.1111/bph.12181}
}

@article{alexandrov2013-23778113,
  author  = {Alexandrov, P. N. and Zhao, Y. and Jones, B. M. and Bhattacharjee, S. and Lukiw, W. J.},
  title   = {{Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line}},
  journal = {Journal of inorganic biochemistry},
  year    = {2013},
  doi     = {10.1016/j.jinorgbio.2013.05.010},
  pmid    = {23778113},
  url     = {https://doi.org/10.1016/j.jinorgbio.2013.05.010}
}

@article{zhao2013-23462268,
  author  = {Zhao, Y. and Bhattacharjee, S. and Jones, B. M. and Dua, P. and Alexandrov, P. N. and Hill, J. M. and Lukiw, W. J.},
  title   = {{Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a}},
  journal = {Neuroreport},
  year    = {2013},
  doi     = {10.1097/wnr.0b013e32835fb6b0},
  pmid    = {23462268},
  url     = {https://doi.org/10.1097/wnr.0b013e32835fb6b0}
}

@article{rohn2013-23533697,
  author  = {Rohn, Troy T},
  title   = {{The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer's disease}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2013},
  doi     = {10.1155/2013/860959},
  pmid    = {23533697},
  url     = {https://doi.org/10.1155/2013/860959}
}

@article{jiang2013-23407992,
  author  = {Jiang, T. and Yu, J. T. and Zhu, X. C. and Tan, L.},
  title   = {{TREM2 in Alzheimer's disease}},
  journal = {Molecular neurobiology},
  year    = {2013},
  doi     = {10.1007/s12035-013-8424-8},
  pmid    = {23407992},
  url     = {https://doi.org/10.1007/s12035-013-8424-8}
}

@article{benitez2013-23391427,
  author  = {Benitez, B. A. and Cooper, B. and Pastor, P. and Jin, S. C. and Lorenzo, E. and Cervantes, S. and Cruchaga, C.},
  title   = {{TREM2 is associated with the risk of Alzheimer's disease in Spanish population}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2012.12.018},
  pmid    = {23391427},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2012.12.018}
}

@article{boche2013-23252647,
  author  = {Boche, D. and Perry, V. H. and Nicoll, J. A.},
  title   = {{Review: activation patterns of microglia and their identification in the human brain}},
  journal = {Neuropathology and applied neurobiology},
  year    = {2013},
  doi     = {10.1111/nan.12011},
  pmid    = {23252647},
  url     = {https://doi.org/10.1111/nan.12011}
}

@article{sierra2013-23386811,
  author  = {Sierra, A. and Abiega, O. and Shahraz, A. and Neumann, H.},
  title   = {{Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2013},
  doi     = {10.3389/fncel.2013.00006},
  pmid    = {23386811},
  url     = {https://doi.org/10.3389/fncel.2013.00006}
}

@article{sieber2013-23301011,
  author  = {Sieber, M. W. and Jaenisch, N. and Brehm, M. and Guenther, M. and Linnartz-Gerlach, B. and Neumann, H. and Witte, O. W. and Frahm, C.},
  title   = {{Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0052982},
  pmid    = {23301011},
  url     = {https://doi.org/10.1371/journal.pone.0052982}
}

@article{pottier2013-23380991,
  author  = {Pottier, C. and Wallon, D. and Rousseau, S. and Rovelet-Lecrux, A. and Richard, A. C. and Rollin-Sillaire, A. and Frebourg, T. and Campion, D. and others},
  title   = {{TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-122311},
  pmid    = {23380991},
  url     = {https://doi.org/10.3233/jad-122311}
}

@article{guerreiro2013-23318515,
  author  = {Guerreiro, R. J. and Lohmann, E. and Brás, J. M. and Gibbs, JR. and Rohrer, J. D. and Gurunlian, N. and Dursun, B. and Bilgic, B. and others},
  title   = {{Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.579},
  pmid    = {23318515},
  url     = {https://doi.org/10.1001/jamaneurol.2013.579}
}

@article{guerreiro2013-23150934,
  author  = {Guerreiro, R. and Wojtas, A. and Bras, J. and Carrasquillo, M. and Rogaeva, E. and Majounie, E. and Cruchaga, C. and Sassi, C. and others},
  title   = {{TREM2 variants in Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2013},
  doi     = {10.1056/nejmoa1211851},
  pmid    = {23150934},
  url     = {https://doi.org/10.1056/nejmoa1211851}
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@article{jonsson2013-23150908,
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  title   = {{Variant of TREM2 associated with the risk of Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2013},
  doi     = {10.1056/nejmoa1211103},
  pmid    = {23150908},
  url     = {https://doi.org/10.1056/nejmoa1211103}
}

@article{lehmann2012-22610069,
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  title   = {{An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration}},
  journal = {Nature neuroscience},
  year    = {2012},
  doi     = {10.1038/nn.3113},
  pmid    = {22610069},
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@article{rubioperez2012-22566778,
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  title   = {{A review: inflammatory process in Alzheimer's disease, role of cytokines}},
  journal = {TheScientificWorldJournal},
  year    = {2012},
  doi     = {10.1100/2012/756357},
  pmid    = {22566778},
  url     = {https://doi.org/10.1100/2012/756357}
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@article{otero2012-22312126,
  author  = {Otero, K. and Shinohara, M. and Zhao, H. and Cella, M. and Gilfillan, S. and Colucci, A. and Faccio, R. and Ross, F. P. and others},
  title   = {{TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2012},
  doi     = {10.4049/jimmunol.1102836},
  pmid    = {22312126},
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@article{martinmoreno2012-22248049,
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  title   = {{Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice}},
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  year    = {2012},
  doi     = {10.1186/1742-2094-9-8},
  pmid    = {22248049},
  url     = {https://doi.org/10.1186/1742-2094-9-8}
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@article{wysscoray2012-22315714,
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  title   = {{Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature}},
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  year    = {2012},
  doi     = {10.1101/cshperspect.a006346},
  pmid    = {22315714},
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}

@article{ito2011-21956652,
  author  = {Ito, Hiroaki and Hamerman, Jessica A.},
  title   = {{TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells}},
  journal = {European Journal of Immunology},
  year    = {2011},
  doi     = {10.1002/eji.201141679},
  pmid    = {21956652},
  url     = {https://doi.org/10.1002/eji.201141679}
}

@article{veerhuis2011-21546088,
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  title   = {{Complement in the brain}},
  journal = {Molecular immunology},
  year    = {2011},
  doi     = {10.1016/j.molimm.2011.04.003},
  pmid    = {21546088},
  url     = {https://doi.org/10.1016/j.molimm.2011.04.003}
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@article{alvarezerviti2011-21423189,
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  title   = {{Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes}},
  journal = {Nature biotechnology},
  year    = {2011},
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  pmid    = {21423189},
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@article{numasawa2011-21834902,
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  title   = {{Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family}},
  journal = {European journal of neurology},
  year    = {2011},
  doi     = {10.1111/j.1468-1331.2010.03311.x},
  pmid    = {21834902},
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@article{swardfager2010-20692646,
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  title   = {{A meta-analysis of cytokines in Alzheimer's disease}},
  journal = {Biological psychiatry},
  year    = {2010},
  doi     = {10.1016/j.biopsych.2010.06.012},
  pmid    = {20692646},
  url     = {https://doi.org/10.1016/j.biopsych.2010.06.012}
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@article{melchior2010-20640189,
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  title   = {{Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease}},
  journal = {ASN neuro},
  year    = {2010},
  doi     = {10.1042/an20100010},
  pmid    = {20640189},
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@article{peng2010-20484116,
  author  = {Peng, Q. and Malhotra, S. and Torchia, J. A. and Kerr, W. G. and Coggeshall, K. M. and Humphrey, M. B.},
  title   = {{TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1}},
  journal = {Science signaling},
  year    = {2010},
  doi     = {10.1126/scisignal.2000500},
  pmid    = {20484116},
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@article{glass2010-20303880,
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  journal = {Cell},
  year    = {2010},
  doi     = {10.1016/j.cell.2010.02.016},
  pmid    = {20303880},
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@article{amor2010-20561356,
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  title   = {{Inflammation in neurodegenerative diseases}},
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  year    = {2010},
  doi     = {10.1111/j.1365-2567.2009.03225.x},
  pmid    = {20561356},
  url     = {https://doi.org/10.1111/j.1365-2567.2009.03225.x}
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@article{sims2010-20192808,
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  title   = {{HMGB1 and RAGE in inflammation and cancer}},
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  year    = {2010},
  doi     = {10.1146/annurev.immunol.021908.132603},
  pmid    = {20192808},
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@article{ruan2009-19747158,
  author  = {Ruan, Lingfei and Kang, Zhoujun and Pei, Gang and Le, Yingying},
  title   = {{Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease}},
  journal = {Current Alzheimer Research},
  year    = {2009},
  doi     = {10.2174/156720509790147070},
  pmid    = {19747158},
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@article{ting2009-20003262,
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  title   = {{Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease}},
  journal = {Journal of Neuroinflammation},
  year    = {2009},
  doi     = {10.1186/1742-2094-6-36},
  pmid    = {20003262},
  url     = {https://doi.org/10.1186/1742-2094-6-36}
}

@article{frankcannon2009-19917131,
  author  = {Frank-Cannon, Tamy C. and Alto, Laura Taylor and McAlpine, Fiona E and Tansey, Malú G.},
  title   = {{Does neuroinflammation fan the flame in neurodegenerative diseases?}},
  journal = {Molecular Neurodegeneration},
  year    = {2009},
  doi     = {10.1186/1750-1326-4-47},
  pmid    = {19917131},
  url     = {https://doi.org/10.1186/1750-1326-4-47}
}

@article{tansey2010-19913097,
  author  = {Tansey, M. G. and Goldberg, M. S.},
  title   = {{Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention}},
  journal = {Neurobiology of disease},
  year    = {2010},
  doi     = {10.1016/j.nbd.2009.11.004},
  pmid    = {19913097},
  url     = {https://doi.org/10.1016/j.nbd.2009.11.004}
}

@article{hein2010-19825412,
  author  = {Hein, A. M. and Stasko, M. R. and Matousek, S. B. and Scott-McKean, J. J. and Maier, S. F. and Olschowka, J. A. and Costa, A. C. and O'Banion, M. K.},
  title   = {{Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2010},
  doi     = {10.1016/j.bbi.2009.10.002},
  pmid    = {19825412},
  url     = {https://doi.org/10.1016/j.bbi.2009.10.002}
}

@article{ghosh2009-19864567,
  author  = {Ghosh, A. and Roy, A. and Matras, J. and Brahmachari, S. and Gendelman, H. E. and Pahan, K.},
  title   = {{Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.4144-09.2009},
  pmid    = {19864567},
  url     = {https://doi.org/10.1523/jneurosci.4144-09.2009}
}

@article{reedgeaghan2009-19776284,
  author  = {Reed-Geaghan, Erin G. and Savage, Julie C. and Hise, Amy G. and Landreth, Gary E.},
  title   = {{CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation}},
  journal = {Journal of Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.3158-09.2009},
  pmid    = {19776284},
  url     = {https://doi.org/10.1523/jneurosci.3158-09.2009}
}

@article{holmes2009-19738171,
  author  = {Holmes, C. and Cunningham, C. and Zotova, E. and Woolford, J. and Dean, C. and Kerr, S. and Culliford, D. and Perry, V. H.},
  title   = {{Systemic inflammation and disease progression in Alzheimer disease}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181b6bb95},
  pmid    = {19738171},
  url     = {https://doi.org/10.1212/wnl.0b013e3181b6bb95}
}

@article{stefano2009-19457124,
  author  = {Stefano, L. and Racchetti, G. and Bianco, F. and Passini, N. and Gupta, R. S. and Panina Bordignon, P. and Meldolesi, J.},
  title   = {{The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06130.x},
  pmid    = {19457124},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.06130.x}
}

@article{hsieh2009-19302484,
  author  = {Hsieh, C. L. and Koike, M. and Spusta, S. C. and Niemi, E. C. and Yenari, M. and Nakamura, M. C. and Seaman, W. E.},
  title   = {{A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06042.x},
  pmid    = {19302484},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.06042.x}
}

@article{ndiaye2009-19171755,
  author  = {N’Diaye, Elsa-Noah and Branda, Catherine and Branda, Steven S. and Nevarez, Lisette and Colonna, Marco and Lowell, Clifford A. and Hamerman, Jessica A. and Seaman, William E.},
  title   = {{TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria}},
  journal = {The Journal of Cell Biology},
  year    = {2009},
  doi     = {10.1083/jcb.200808080},
  pmid    = {19171755},
  url     = {https://doi.org/10.1083/jcb.200808080}
}

@article{seno2009-19109436,
  author  = {Seno, H. and Miyoshi, H. and Brown, S. L. and Geske, M. J. and Colonna, M. and Stappenbeck, T. S.},
  title   = {{Efficient colonic mucosal wound repair requires Trem2 signaling}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0803343106},
  pmid    = {19109436},
  url     = {https://doi.org/10.1073/pnas.0803343106}
}

@article{bazan2008-19018037,
  author  = {Bazan, Nicolas Guillermo},
  title   = {{Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease}},
  journal = {Journal of Lipid Research},
  year    = {2008},
  doi     = {10.1194/jlr.r800068-jlr200},
  pmid    = {19018037},
  url     = {https://doi.org/10.1194/jlr.r800068-jlr200}
}

@article{hermes2008-18947414,
  author  = {Hermes, G. and Ajioka, J. W. and Kelly, K. A. and Mui, E. and Roberts, F. and Kasza, K. and Mayr, T. and Kirisits, M. J. and others},
  title   = {{Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-48},
  pmid    = {18947414},
  url     = {https://doi.org/10.1186/1742-2094-5-48}
}

@article{mcafoose2009-18996146,
  author  = {McAfoose, J. and Baune, B. T.},
  title   = {{Evidence for a cytokine model of cognitive function}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2009},
  doi     = {10.1016/j.neubiorev.2008.10.005},
  pmid    = {18996146},
  url     = {https://doi.org/10.1016/j.neubiorev.2008.10.005}
}

@article{mccoy2008-18925972,
  author  = {McCoy, M. K. and Tansey, M. G.},
  title   = {{TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-45},
  pmid    = {18925972},
  url     = {https://doi.org/10.1186/1742-2094-5-45}
}

@article{frank2008-18551625,
  author  = {Frank, S. and Burbach, G. J. and Bonin, M. and Walter, M. and Streit, W. and Bechmann, I. and Deller, T.},
  title   = {{TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice}},
  journal = {Glia},
  year    = {2008},
  doi     = {10.1002/glia.20710},
  pmid    = {18551625},
  url     = {https://doi.org/10.1002/glia.20710}
}

@article{lukiw2008-18801740,
  author  = {Lukiw, W. J. and Zhao, Y. and Cui, J. G.},
  title   = {{An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m805371200},
  pmid    = {18801740},
  url     = {https://doi.org/10.1074/jbc.m805371200}
}

@article{piccio2008-18790823,
  author  = {Piccio, Laura M. and Buonsanti, Cecilia and Cella, Marina and Tassi, Ilaria and Schmidt, Robert E. and Fenoglio, Chiara and Rinker, John Robert and Naismith, Robert T. and Panina‐Bordignon, Paola and Passini, Nadia and Galimberti, Daniela and Scarpini, Elio Angelo and Colonna, Marco and Cross, Anne Haney},
  title   = {{Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation}},
  journal = {Brain},
  year    = {2008},
  doi     = {10.1093/brain/awn217},
  pmid    = {18790823},
  url     = {https://doi.org/10.1093/brain/awn217}
}

@article{chouery2008-18546367,
  author  = {Chouery, E. and Delague, V. and Bergougnoux, A. and Koussa, S. and Serre, J. L. and Mégarbané, A.},
  title   = {{Mutations in TREM2 lead to pure early-onset dementia without bone cysts}},
  journal = {Human mutation},
  year    = {2008},
  doi     = {10.1002/humu.20836},
  pmid    = {18546367},
  url     = {https://doi.org/10.1002/humu.20836}
}

@article{lee2008-18759972,
  author  = {Lee, J. W. and Lee, Y. K. and Yuk, D. Y. and Choi, D. Y. and Ban, S. B. and Oh, K. W. and Hong, J. T.},
  title   = {{Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-37},
  pmid    = {18759972},
  url     = {https://doi.org/10.1186/1742-2094-5-37}
}

@article{halle2008-18604209,
  author  = {Halle, A. and Hornung, V. and Petzold, G. C. and Stewart, C. R. and Monks, B. G. and Reinheckel, T. and Fitzgerald, K. A. and Latz, E. and others},
  title   = {{The NALP3 inflammasome is involved in the innate immune response to amyloid-beta}},
  journal = {Nature immunology},
  year    = {2008},
  doi     = {10.1038/ni.1636},
  pmid    = {18604209},
  url     = {https://doi.org/10.1038/ni.1636}
}

@article{jin2008-18510752,
  author  = {Jin, J. J. and Kim, H. D. and Maxwell, J. A. and Li, L. and Fukuchi, K.},
  title   = {{Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-23},
  pmid    = {18510752},
  url     = {https://doi.org/10.1186/1742-2094-5-23}
}

@article{thrash2009-18404378,
  author  = {Thrash, J. C. and Torbett, B. E. and Carson, M. J.},
  title   = {{Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease}},
  journal = {Neurochemical research},
  year    = {2009},
  doi     = {10.1007/s11064-008-9657-1},
  pmid    = {18404378},
  url     = {https://doi.org/10.1007/s11064-008-9657-1}
}

@article{charles2008-18391000,
  author  = {Charles, J. F. and Humphrey, M. B. and Zhao, X. and Quarles, E. and Nakamura, M. C. and Aderem, A. and Seaman, W. E. and Smith, K. D.},
  title   = {{The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12}},
  journal = {Infection and immunity},
  year    = {2008},
  doi     = {10.1128/iai.00115-08},
  pmid    = {18391000},
  url     = {https://doi.org/10.1128/iai.00115-08}
}

@article{takahashi2007-17425404,
  author  = {Takahashi, K. and Prinz, M. and Stagi, M. and Chechneva, O. and Neumann, H.},
  title   = {{TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis}},
  journal = {PLoS medicine},
  year    = {2007},
  doi     = {10.1371/journal.pmed.0040124},
  pmid    = {17425404},
  url     = {https://doi.org/10.1371/journal.pmed.0040124}
}

@article{nakazawa2007-17284607,
  author  = {Nakazawa, T. and Hisatomi, T. and Nakazawa, C. and Noda, K. and Maruyama, K. and She, H. and Matsubara, A. and Miyahara, S. and others},
  title   = {{Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2007},
  doi     = {10.1073/pnas.0608167104},
  pmid    = {17284607},
  url     = {https://doi.org/10.1073/pnas.0608167104}
}

@article{neumann2007-17239445,
  author  = {Neumann, H. and Takahashi, K.},
  title   = {{Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis}},
  journal = {Journal of neuroimmunology},
  year    = {2007},
  doi     = {10.1016/j.jneuroim.2006.11.032},
  pmid    = {17239445},
  url     = {https://doi.org/10.1016/j.jneuroim.2006.11.032}
}

@article{rogers2007-17678964,
  author  = {Rogers, J. and Mastroeni, D. and Leonard, B. and Joyce, J. and Grover, A.},
  title   = {{Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder?}},
  journal = {International review of neurobiology},
  year    = {2007},
  doi     = {10.1016/s0074-7742(07)82012-5},
  pmid    = {17678964},
  url     = {https://doi.org/10.1016/s0074-7742(07)82012-5}
}

@article{carson2006-16972896,
  author  = {Carson, M. J. and Doose, J. M. and Melchior, B. and Schmid, C. D. and Ploix, C. C.},
  title   = {{CNS immune privilege: hiding in plain sight}},
  journal = {Immunological reviews},
  year    = {2006},
  doi     = {10.1111/j.1600-065x.2006.00441.x},
  pmid    = {16972896},
  url     = {https://doi.org/10.1111/j.1600-065x.2006.00441.x}
}

@article{turnbull2006-16951310,
  author  = {Turnbull, Isaiah R. and Gilfillan, Susan and Cella, Marina and Aoshi, Taiki and Miller, Mark J. and Piccio, Laura M. and Hernandez, Maristela and Colonna, Marco},
  title   = {{Cutting Edge: TREM-2 Attenuates Macrophage Activation}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.6.3520},
  pmid    = {16951310},
  url     = {https://doi.org/10.4049/jimmunol.177.6.3520}
}

@article{hamerman2006-16887962,
  author  = {Hamerman, Jessica A. and Jarjoura, Jessica R and Humphrey, Mary Beth and Nakamura, Mary C. and Seaman, William E. and Lanier, Lewis L.},
  title   = {{Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.4.2051},
  pmid    = {16887962},
  url     = {https://doi.org/10.4049/jimmunol.177.4.2051}
}

@article{maezawa2006-16603079,
  author  = {Maezawa, Izumi and Maeda, Nobuyo and Montine, Thomas J and Montine, Kathleen S},
  title   = {{Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-10},
  pmid    = {16603079},
  url     = {https://doi.org/10.1186/1742-2094-3-10}
}

@article{lucas2006-16402109,
  author  = {Lucas, S. M. and Rothwell, N. J. and Gibson, R. M.},
  title   = {{The role of inflammation in CNS injury and disease}},
  journal = {British journal of pharmacology},
  year    = {2006},
  doi     = {10.1038/sj.bjp.0706400},
  pmid    = {16402109},
  url     = {https://doi.org/10.1038/sj.bjp.0706400}
}

@article{rosenberg2005-16401549,
  author  = {Rosenberg, P. B.},
  title   = {{Clinical aspects of inflammation in Alzheimer's disease}},
  journal = {International review of psychiatry (Abingdon, England)},
  year    = {2005},
  doi     = {10.1080/02646830500382037},
  pmid    = {16401549},
  url     = {https://doi.org/10.1080/02646830500382037}
}

@article{humphrey2006-16418779,
  author  = {Humphrey, M. B. and Daws, M. R. and Spusta, S. C. and Niemi, E. C. and Torchia, J. A. and Lanier, L. L. and Seaman, W. E. and Nakamura, M. C.},
  title   = {{TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function}},
  journal = {Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year    = {2006},
  doi     = {10.1359/jbmr.051016},
  pmid    = {16418779},
  url     = {https://doi.org/10.1359/jbmr.051016}
}

@article{cunningham2005-16207887,
  author  = {Cunningham, Colm M. and Wilcockson, David Charles and Campion, Suzanne and Lunnon, Katie and Perry, Victor Hugh},
  title   = {{Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration}},
  journal = {Journal of Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2614-05.2005},
  pmid    = {16207887},
  url     = {https://doi.org/10.1523/jneurosci.2614-05.2005}
}

@article{kitazawa2005-16192374,
  author  = {Kitazawa, M. and Oddo, S. and Yamasaki, T. R. and Green, K. N. and LaFerla, F. M.},
  title   = {{Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2868-05.2005},
  pmid    = {16192374},
  url     = {https://doi.org/10.1523/jneurosci.2868-05.2005}
}

@article{floden2005-15758166,
  author  = {Floden, A. M. and Li, S. and Combs, C. K.},
  title   = {{Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.4998-04.2005},
  pmid    = {15758166},
  url     = {https://doi.org/10.1523/jneurosci.4998-04.2005}
}

@article{kiialainen2005-15686960,
  author  = {Kiialainen, A. and Hovanes, K. and Paloneva, J. and Kopra, O. and Peltonen, L.},
  title   = {{Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2004.09.007},
  pmid    = {15686960},
  url     = {https://doi.org/10.1016/j.nbd.2004.09.007}
}

@article{ramirez2005-15728830,
  author  = {Ramírez, B. G. and Blázquez, C. and Gómez del Pulgar, T. and Guzmán, M. and de Ceballos, M. L.},
  title   = {{Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.4540-04.2005},
  pmid    = {15728830},
  url     = {https://doi.org/10.1523/jneurosci.4540-04.2005}
}

@article{lavrik2005-15654015,
  author  = {Lavrik, Inna N. and Golks, Alexander and Krammer, Peter H.},
  title   = {{Death receptor signaling}},
  journal = {Journal of Cell Science},
  year    = {2005},
  doi     = {10.1242/jcs.01610},
  pmid    = {15654015},
  url     = {https://doi.org/10.1242/jcs.01610}
}

@article{sessa2004-15548205,
  author  = {Sessa, G. and Podini, P. and Mariani, M. and Meroni, A. and Spreafico, R. and Sinigaglia, F. and Colonna, M. and Panina, P. and others},
  title   = {{Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia}},
  journal = {The European journal of neuroscience},
  year    = {2004},
  doi     = {10.1111/j.1460-9568.2004.03729.x},
  pmid    = {15548205},
  url     = {https://doi.org/10.1111/j.1460-9568.2004.03729.x}
}

@article{streit2004-15285801,
  author  = {Streit, W. J. and Mrak, R. E. and Griffin, W. S.},
  title   = {{Microglia and neuroinflammation: a pathological perspective}},
  journal = {Journal of neuroinflammation},
  year    = {2004},
  doi     = {10.1186/1742-2094-1-14},
  pmid    = {15285801},
  url     = {https://doi.org/10.1186/1742-2094-1-14}
}

@article{saleh2004-15129283,
  author  = {Saleh, M. and Vaillancourt, J. P. and Graham, R. K. and Huyck, M. and Srinivasula, S. M. and Alnemri, E. S. and Steinberg, M. H. and Nolan, V. and others},
  title   = {{Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms}},
  journal = {Nature},
  year    = {2004},
  doi     = {10.1038/nature02451},
  pmid    = {15129283},
  url     = {https://doi.org/10.1038/nature02451}
}

@article{benito2003-14657172,
  author  = {Benito, Cristina and Núñez, Estefanía and Tolón, Rosa Maria and Carrier, Erica J. and Rábano, Alberto and Hillard, Cecilia J. and Romero, Julián},
  title   = {{Cannabinoid CB2Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains}},
  journal = {Journal of Neuroscience},
  year    = {2003},
  doi     = {10.1523/jneurosci.23-35-11136.2003},
  pmid    = {14657172},
  url     = {https://doi.org/10.1523/jneurosci.23-35-11136.2003}
}

@article{paloneva2003-12925681,
  author  = {Paloneva, J. and Mandelin, J. and Kiialainen, A. and Bohling, T. and Prudlo, J. and Hakola, P. and Haltia, M. and Konttinen, Y. T. and others},
  title   = {{DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features}},
  journal = {The Journal of experimental medicine},
  year    = {2003},
  doi     = {10.1084/jem.20030027},
  pmid    = {12925681},
  url     = {https://doi.org/10.1084/jem.20030027}
}

@article{daws2003-12847223,
  author  = {Daws, Michael R. and Sullam, Paul M. and Niemi, Eréne C. and Chen, Thomas T. and Tchao, Nadia K. and Seaman, William E.},
  title   = {{Pattern Recognition by TREM-2: Binding of Anionic Ligands}},
  journal = {The Journal of Immunology},
  year    = {2003},
  doi     = {10.4049/jimmunol.171.2.594},
  pmid    = {12847223},
  url     = {https://doi.org/10.4049/jimmunol.171.2.594}
}

@article{colonna2003-12776204,
  author  = {Colonna, M.},
  title   = {{TREMs in the immune system and beyond}},
  journal = {Nature reviews. Immunology},
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