% alzhub.org topic: macrophages
% Source: https://alzhub.org/topic/macrophages
% 363 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{liao2026-42230432,
  author  = {Liao, Y. and Ye, S. and Zhao, L. and Zhou, M. and Wen, Y. and Zhu, Y. and Huang, J. and Zhang, L. and others},
  title   = {{Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies}},
  journal = {Molecular neurobiology},
  year    = {2026},
  doi     = {10.1007/s12035-026-05925-6},
  pmid    = {42230432},
  url     = {https://doi.org/10.1007/s12035-026-05925-6}
}

@article{mummery2026-41787076,
  author  = {Mummery, C. J. and Mayorga, A. J. and Simmons, A. and Chow, T. W. and Burgess, B. and Nguyen, T. and Gao, J. and Budda, B. and Park, L. Q. and Gupta, R. and Li, C. and Shi, L. and others},
  title   = {{The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial}},
  journal = {Nature Medicine},
  year    = {2026},
  doi     = {10.1038/s41591-026-04273-1},
  pmid    = {41787076},
  url     = {https://doi.org/10.1038/s41591-026-04273-1}
}

@article{che2026-41512220,
  author  = {Che, Yanfei and Yu, Ziman and Ji, Songjie and Yang, Dan},
  title   = {{Decoding TREM2 Signaling Pathways}},
  journal = {Neurology Neuroimmunology \& Neuroinflammation},
  year    = {2026},
  doi     = {10.1212/nxi.0000000000200527},
  pmid    = {41512220},
  url     = {https://doi.org/10.1212/nxi.0000000000200527}
}

@article{polydoro2025-41447159,
  author  = {Polydoro, Manuela and Geric, Ivana and Zheng, Jin and Bisgaard, Tina Sommer and Comer, Ashley L. and Sans, Laura and Lu, Ashley and Vilstrup, Joachim and others},
  title   = {{A Novel TREM2 Small Molecule Agonist MTX46943 Re‐Programs Human Microglia and Reduces Amyloid Pathology In Vivo}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_100777},
  pmid    = {41447159},
  url     = {https://doi.org/10.1002/alz70859_100777}
}

@article{tuil2025-41447298,
  author  = {Tuil, Marie Emilie and Allehyany, Bshaier and Punnota, Rifa Sanjida and Edison, Paul},
  title   = {{CSF sTREM2 is associated with distinct microglial responses with separate effects on Alzheimer's pathology in the disease's trajectory}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_100766},
  pmid    = {41447298},
  url     = {https://doi.org/10.1002/alz70856_100766}
}

@article{akgun2025-41444117,
  author  = {Akgün, Bilçağ and Cornejo-Olivas, Mario R and Mena, Pedro Ramon and Adams, Larry Deon and Celis, Katrina and Whitehead, Patrice G. and Hamilton‐Nelson, Kara L. and Ríos‐Pinto, Julia and others},
  title   = {{Peruvian Population Empowers Discovery of a TREM2 Missense Variant in Alzheimer Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_105970},
  pmid    = {41444117},
  url     = {https://doi.org/10.1002/alz70855_105970}
}

@article{boreland2025-41205777,
  author  = {Boreland, Andrew J. and Abbo, Yara and Li, Xindi and Stillitano, Alessandro C. and Zhang, Siwei and Duan, Jubao and Pang, Zhiping P. and Hart, Ronald P.},
  title   = {{Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model}},
  journal = {Alcohol},
  year    = {2025},
  doi     = {10.1016/j.alcohol.2025.10.006},
  pmid    = {41205777},
  url     = {https://doi.org/10.1016/j.alcohol.2025.10.006}
}

@article{pilat2026-41109213,
  author  = {Pilat, D. J. and Le, H. and Prokopenko, D. and Lin, C. J. and Eimer, W. A. and Quinti, L. and Gavrilles, E. P. and Garcia, S. N. and Heitman, S. N. and McGinty, D. and Cetinbas, M. and others},
  title   = {{The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease by impairing microglial function}},
  journal = {Neuron},
  year    = {2026},
  doi     = {10.1016/j.neuron.2025.09.032},
  pmid    = {41109213},
  url     = {https://doi.org/10.1016/j.neuron.2025.09.032}
}

@article{albanus2025-40737431,
  author  = {Albanus, Ricardo D’Oliveira and Finan, Gina M. and Brase, Logan and Sweeney, Nicholas and Kim, Tae Yeon and Chen, Shuo and Ryoo, Yeonsu and others},
  title   = {{Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease}},
  journal = {Science Translational Medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.adx0027},
  pmid    = {40737431},
  url     = {https://doi.org/10.1126/scitranslmed.adx0027}
}

@article{kraller2025-40405265,
  author  = {Kraller, Markus and Faßbender, Julia and Jabali, Ammar and Kroeger, Joseph A. and Fink, Barbara and Popper, Bastian and Ungerer, Martin and Christlmeier, Miriam A.},
  title   = {{Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01759-x},
  pmid    = {40405265},
  url     = {https://doi.org/10.1186/s13195-025-01759-x}
}

@article{zhang2025-40247363,
  author  = {Zhang, L. and Xiang, X. and Li, Y. and Bu, G. and Chen, X. F.},
  title   = {{TREM2 and sTREM2 in Alzheimer's disease: from mechanisms to therapies}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00834-z},
  pmid    = {40247363},
  url     = {https://doi.org/10.1186/s13024-025-00834-z}
}

@article{yagi2025-40143815,
  author  = {Yagi, Hitomi and Boeck, Myriam and Neilsen, Katherine and Yang, Jay and Ko, Minji and Tomita, Yohei and Negishi, Kazuno and Fu, Zhongjie and others},
  title   = {{Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes—Brief Report}},
  journal = {Arteriosclerosis Thrombosis and Vascular Biology},
  year    = {2025},
  doi     = {10.1161/atvbaha.124.321809},
  pmid    = {40143815},
  url     = {https://doi.org/10.1161/atvbaha.124.321809}
}

@article{cui2025-39971937,
  author  = {Cui, H. and Banerjee, S. and Xie, N. and Hussain, M. and Jaiswal, A. and Liu, H. and Kulkarni, T. and Antony, V. B. and others},
  title   = {{TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-57024-0},
  pmid    = {39971937},
  url     = {https://doi.org/10.1038/s41467-025-57024-0}
}

@article{fremuth2025-39817909,
  author  = {Fremuth, L. E. and Hu, H. and van de Vlekkert, D. and Annunziata, I. and Weesner, J. A. and d'Azzo, Alessandra},
  title   = {{Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation}},
  journal = {Cell reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2024.115204},
  pmid    = {39817909},
  url     = {https://doi.org/10.1016/j.celrep.2024.115204}
}

@article{long2024-39444037,
  author  = {Long, H. and Simmons, A. and Mayorga, A. and Burgess, B. and Nguyen, T. and Budda, B. and Rychkova, A. and Rhinn, H. and others},
  title   = {{Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01599-1},
  pmid    = {39444037},
  url     = {https://doi.org/10.1186/s13195-024-01599-1}
}

@article{ganguly2024-39172787,
  author  = {Ganguly, S. and Rosenthal, S. B. and Ishizuka, K. and Troutman, T. D. and Rohm, T. V. and Khader, N. and Aleman-Muench, G. and Sano, Y. and others},
  title   = {{Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2024},
  doi     = {10.1073/pnas.2405746121},
  pmid    = {39172787},
  url     = {https://doi.org/10.1073/pnas.2405746121}
}

@article{yin2024-38915213,
  author  = {Yin, Y. and Yang, H. and Li, R. and Wu, G. and Qin, Q. and Tang, Y.},
  title   = {{A systematic review of the role of TREM2 in Alzheimer's disease}},
  journal = {Chinese medical journal},
  year    = {2024},
  doi     = {10.1097/cm9.0000000000003000},
  pmid    = {38915213},
  url     = {https://doi.org/10.1097/cm9.0000000000003000}
}

@article{cui2024-38849370,
  author  = {Cui, Y. and Chen, C. and Tang, Z. and Yuan, W. and Yue, K. and Cui, P. and Qiu, X. and Zhang, H. and others},
  title   = {{TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice}},
  journal = {Cell death \& disease},
  year    = {2024},
  doi     = {10.1038/s41419-024-06756-w},
  pmid    = {38849370},
  url     = {https://doi.org/10.1038/s41419-024-06756-w}
}

@article{zhong2024-38788719,
  author  = {Zhong, J. and Xing, X. and Gao, Y. and Pei, L. and Lu, C. and Sun, H. and Lai, Y. and Du, K. and others},
  title   = {{Distinct roles of TREM2 in central nervous system cancers and peripheral cancers}},
  journal = {Cancer cell},
  year    = {2024},
  doi     = {10.1016/j.ccell.2024.05.001},
  pmid    = {38788719},
  url     = {https://doi.org/10.1016/j.ccell.2024.05.001}
}

@article{wang2024-38841103,
  author  = {Wang, R. and Zhan, Y. and Zhu, W. and Yang, Q. and Pei, J.},
  title   = {{Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2024},
  doi     = {10.3389/fnagi.2024.1407980},
  pmid    = {38841103},
  url     = {https://doi.org/10.3389/fnagi.2024.1407980}
}

@article{shi2025-38769824,
  author  = {Shi, Q. and Gutierrez, R. A. and Bhat, M. A.},
  title   = {{Microglia, Trem2, and Neurodegeneration}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2025},
  doi     = {10.1177/10738584241254118},
  pmid    = {38769824},
  url     = {https://doi.org/10.1177/10738584241254118}
}

@article{diluccia2024-38758808,
  author  = {Di Luccia, B. and Molgora, M. and Khantakova, D. and Jaeger, N. and Chang, H. W. and Czepielewski, R. S. and Helmink, B. A. and Onufer, E. J. and others},
  title   = {{TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy}},
  journal = {Science immunology},
  year    = {2024},
  doi     = {10.1126/sciimmunol.adi5374},
  pmid    = {38758808},
  url     = {https://doi.org/10.1126/sciimmunol.adi5374}
}

@article{patterson2024-38695172,
  author  = {Patterson, M. T. and Xu, Y. and Hillman, H. and Osinski, V. and Schrank, P. R. and Kennedy, A. E. and Barrow, F. and Zhu, A. and others},
  title   = {{Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2024},
  doi     = {10.1161/atvbaha.124.320797},
  pmid    = {38695172},
  url     = {https://doi.org/10.1161/atvbaha.124.320797}
}

@article{rachmian2024-38637622,
  author  = {Rachmian, N. and Medina, S. and Cherqui, U. and Akiva, H. and Deitch, D. and Edilbi, D. and Croese, T. and Salame, T. M. and others},
  title   = {{Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain}},
  journal = {Nature neuroscience},
  year    = {2024},
  doi     = {10.1038/s41593-024-01620-8},
  pmid    = {38637622},
  url     = {https://doi.org/10.1038/s41593-024-01620-8}
}

@article{zhou2024-38478630,
  author  = {Zhou, L. and Qiu, X. and Meng, Z. and Liu, T. and Chen, Z. and Zhang, P. and Kuang, H. and Pan, T. and others},
  title   = {{Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adk1866},
  pmid    = {38478630},
  url     = {https://doi.org/10.1126/scitranslmed.adk1866}
}

@article{piollet2024-38974464,
  author  = {Piollet, M. and Porsch, F. and Rizzo, G. and Kapser, F. and Schulz, D. J. J. and Kiss, M. G. and Schlepckow, K. and Morenas-Rodriguez, E. and others},
  title   = {{TREM2 protects from atherosclerosis by limiting necrotic core formation}},
  journal = {Nature cardiovascular research},
  year    = {2024},
  doi     = {10.1038/s44161-024-00429-9},
  pmid    = {38974464},
  url     = {https://doi.org/10.1038/s44161-024-00429-9}
}

@article{fang2024-38617547,
  author  = {Fang, C. and Zhong, R. and Lu, S. and Yu, G. and Liu, Z. and Yan, C. and Gao, J. and Tang, Y. and others},
  title   = {{TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis}},
  journal = {International journal of biological sciences},
  year    = {2024},
  doi     = {10.7150/ijbs.91519},
  pmid    = {38617547},
  url     = {https://doi.org/10.7150/ijbs.91519}
}

@article{yu2024-38289348,
  author  = {Yu, C. and Lad, E. M. and Mathew, R. and Shiraki, N. and Littleton, S. and Chen, Y. and Hou, J. and Schlepckow, K. and others},
  title   = {{Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231011},
  pmid    = {38289348},
  url     = {https://doi.org/10.1084/jem.20231011}
}

@article{kiianitsa2024-9e48f8fa,
  author  = {Kiianitsa, K. and Lukes, M. E. and Hayes, B. J. and Brutman, J. N. and Valdmanis, P. N. and Bird, T. D. and Raskind, W. H. and Korvatska, O.},
  title   = {{TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing}},
  journal = {Brain},
  year    = {2024}
}

@article{gong2024-38182899,
  author  = {Gong, S. and Zhai, M. and Shi, J. and Yu, G. and Lei, Z. and Shi, Y. and Zeng, Y. and Ju, P. and others},
  title   = {{TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53}},
  journal = {Cell death and differentiation},
  year    = {2024},
  doi     = {10.1038/s41418-023-01252-8},
  pmid    = {38182899},
  url     = {https://doi.org/10.1038/s41418-023-01252-8}
}

@article{wang2024-38172904,
  author  = {Wang, L. and Nykänen, N. P. and Western, D. and Gorijala, P. and Timsina, J. and Li, F. and Wang, Z. and Ali, M. and others},
  title   = {{Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-023-00687-4},
  pmid    = {38172904},
  url     = {https://doi.org/10.1186/s13024-023-00687-4}
}

@article{tagliatti2024-38159572,
  author  = {Tagliatti, E. and Desiato, G. and Mancinelli, S. and Bizzotto, M. and Gagliani, M. C. and Faggiani, E. and Hernández-Soto, R. and Cugurra, A. and others},
  title   = {{Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development}},
  journal = {Immunity},
  year    = {2024},
  doi     = {10.1016/j.immuni.2023.12.002},
  pmid    = {38159572},
  url     = {https://doi.org/10.1016/j.immuni.2023.12.002}
}

@article{yofe2023-37756565,
  author  = {Yofe, I. and Shami, T. and Cohen, N. and Landsberger, T. and Sheban, F. and Stoler-Barak, L. and Yalin, A. and Phan, T. S. and others},
  title   = {{Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary}},
  journal = {Cancer discovery},
  year    = {2023},
  doi     = {10.1158/2159-8290.cd-23-0299},
  pmid    = {37756565},
  url     = {https://doi.org/10.1158/2159-8290.cd-23-0299}
}

@article{wei2024-38042110,
  author  = {Wei, W. and Zhang, L. and Xin, W. and Pan, Y. and Tatenhorst, L. and Hao, Z. and Gerner, S. T. and Huber, S. and others},
  title   = {{TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2024},
  doi     = {10.1016/j.biopha.2023.115962},
  pmid    = {38042110},
  url     = {https://doi.org/10.1016/j.biopha.2023.115962}
}

@article{huang2024-37917301,
  author  = {Huang, P. and Zhang, Z. and Zhang, P. and Feng, J. and Xie, J. and Zheng, Y. and Liang, X. and Zhu, B. and others},
  title   = {{TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells}},
  journal = {Molecular neurobiology},
  year    = {2024},
  doi     = {10.1007/s12035-023-03713-0},
  pmid    = {37917301},
  url     = {https://doi.org/10.1007/s12035-023-03713-0}
}

@article{schlepckow2023-37863592,
  author  = {Schlepckow, K. and Morenas-Rodríguez, E. and Hong, S. and Haass, C.},
  title   = {{Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease}},
  journal = {The Lancet. Neurology},
  year    = {2023},
  doi     = {10.1016/s1474-4422(23)00247-8},
  pmid    = {37863592},
  url     = {https://doi.org/10.1016/s1474-4422(23)00247-8}
}

@article{patterson2023-38646596,
  author  = {Patterson, M. T. and Firulyova, M. M. and Xu, Y. and Hillman, H. and Bishop, C. and Zhu, A. and Hickok, G. H. and Schrank, P. R. and others},
  title   = {{Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis}},
  journal = {Nature cardiovascular research},
  year    = {2023},
  doi     = {10.1038/s44161-023-00354-3},
  pmid    = {38646596},
  url     = {https://doi.org/10.1038/s44161-023-00354-3}
}

@article{zhang2023-37865646,
  author  = {Zhang, X. and Tang, L. and Yang, J. and Meng, L. and Chen, J. and Zhou, L. and Wang, J. and Xiong, M. and others},
  title   = {{Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-42505-x},
  pmid    = {37865646},
  url     = {https://doi.org/10.1038/s41467-023-42505-x}
}

@article{ruedacarrasco2023-37575021,
  author  = {Rueda-Carrasco, J. and Sokolova, D. and Lee, S. E. and Childs, T. and Jurčáková, N. and Crowley, G. and De Schepper, S. and Ge, J. Z. and others},
  title   = {{Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models}},
  journal = {The EMBO journal},
  year    = {2023},
  doi     = {10.15252/embj.2022113246},
  pmid    = {37575021},
  url     = {https://doi.org/10.15252/embj.2022113246}
}

@article{chen2023-37563723,
  author  = {Chen, J. and Zhu, T. and Jiang, G. and Zeng, Q. and Li, Z. and Huang, X.},
  title   = {{Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer}},
  journal = {Molecular cancer},
  year    = {2023},
  doi     = {10.1186/s12943-023-01830-x},
  pmid    = {37563723},
  url     = {https://doi.org/10.1186/s12943-023-01830-x}
}

@article{yoo2023-37541210,
  author  = {Yoo, Y. and Neumayer, G. and Shibuya, Y. and Mader, M. M. and Wernig, M.},
  title   = {{A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease}},
  journal = {Cell stem cell},
  year    = {2023},
  doi     = {10.1016/j.stem.2023.07.006},
  pmid    = {37541210},
  url     = {https://doi.org/10.1016/j.stem.2023.07.006}
}

@article{li2023-37517293,
  author  = {Li, Y. and Xu, H. and Wang, H. and Yang, K. and Luan, J. and Wang, S.},
  title   = {{TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2023},
  doi     = {10.1016/j.biopha.2023.115218},
  pmid    = {37517293},
  url     = {https://doi.org/10.1016/j.biopha.2023.115218}
}

@article{zhong2023-37442133,
  author  = {Zhong, L. and Sheng, X. and Wang, W. and Li, Y. and Zhuo, R. and Wang, K. and Zhang, L. and Hu, D. D. and others},
  title   = {{TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration}},
  journal = {Immunity},
  year    = {2023},
  doi     = {10.1016/j.immuni.2023.06.016},
  pmid    = {37442133},
  url     = {https://doi.org/10.1016/j.immuni.2023.06.016}
}

@article{sun2023-37172094,
  author  = {Sun, R. and Han, R. and McCornack, C. and Khan, S. and Tabor, G. T. and Chen, Y. and Hou, J. and Jiang, H. and others},
  title   = {{TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma}},
  journal = {Science advances},
  year    = {2023},
  doi     = {10.1126/sciadv.ade3559},
  pmid    = {37172094},
  url     = {https://doi.org/10.1126/sciadv.ade3559}
}

@article{guo2023-37133566,
  author  = {Guo, X. and Li, B. and Wen, C. and Zhang, F. and Xiang, X. and Nie, L. and Chen, J. and Mao, L.},
  title   = {{TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2023},
  doi     = {10.1007/s00018-023-04786-9},
  pmid    = {37133566},
  url     = {https://doi.org/10.1007/s00018-023-04786-9}
}

@article{filipello2023-37115208,
  author  = {Filipello, F. and You, S. F. and Mirfakhar, F. S. and Mahali, S. and Bollman, B. and Acquarone, M. and Korvatska, O. and Marsh, J. A. and others},
  title   = {{Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation}},
  journal = {Acta neuropathologica},
  year    = {2023},
  doi     = {10.1007/s00401-023-02568-y},
  pmid    = {37115208},
  url     = {https://doi.org/10.1007/s00401-023-02568-y}
}

@article{parhizkar2023-37099634,
  author  = {Parhizkar, S. and Gent, G. and Chen, Y. and Rensing, N. and Gratuze, M. and Strout, G. and Sviben, S. and Tycksen, E. and others},
  title   = {{Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice}},
  journal = {Science translational medicine},
  year    = {2023},
  doi     = {10.1126/scitranslmed.ade6285},
  pmid    = {37099634},
  url     = {https://doi.org/10.1126/scitranslmed.ade6285}
}

@article{park2023-37081148,
  author  = {Park, M. D. and Reyes-Torres, I. and LeBerichel, J. and Hamon, P. and LaMarche, N. M. and Hegde, S. and Belabed, M. and Troncoso, L. and others},
  title   = {{TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-023-01475-4},
  pmid    = {37081148},
  url     = {https://doi.org/10.1038/s41590-023-01475-4}
}

@article{luo2023-37003186,
  author  = {Luo, Q. and Deng, D. and Li, Y. and Shi, H. and Zhao, J. and Qian, Q. and Wang, W. and Cai, J. and others},
  title   = {{TREM2 Insufficiency Protects against Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization}},
  journal = {International immunopharmacology},
  year    = {2023},
  doi     = {10.1016/j.intimp.2023.110070},
  pmid    = {37003186},
  url     = {https://doi.org/10.1016/j.intimp.2023.110070}
}

@article{molgora2023-36989543,
  author  = {Molgora, M. and Liu, Y. A. and Colonna, M. and Cella, M.},
  title   = {{TREM2: A new player in the tumor microenvironment}},
  journal = {Seminars in immunology},
  year    = {2023},
  doi     = {10.1016/j.smim.2023.101739},
  pmid    = {36989543},
  url     = {https://doi.org/10.1016/j.smim.2023.101739}
}

@article{baughn2023-36927019,
  author  = {Baughn, M. W. and Melamed, Z. and López-Erauskin, J. and Beccari, M. S. and Ling, K. and Zuberi, A. and Presa, M. and Gonzalo-Gil, E. and others},
  title   = {{Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies}},
  journal = {Science (New York, N.Y.)},
  year    = {2023},
  doi     = {10.1126/science.abq5622},
  pmid    = {36927019},
  url     = {https://doi.org/10.1126/science.abq5622}
}

@article{tan2023-36889359,
  author  = {Tan, J. and Fan, W. and Liu, T. and Zhu, B. and Liu, Y. and Wang, S. and Wu, J. and Liu, J. and others},
  title   = {{TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma}},
  journal = {Journal of hepatology},
  year    = {2023},
  doi     = {10.1016/j.jhep.2023.02.032},
  pmid    = {36889359},
  url     = {https://doi.org/10.1016/j.jhep.2023.02.032}
}

@article{xu2023-36829205,
  author  = {Xu, J. and Zhang, L. and Li, M. and He, X. and Luo, J. and Wu, R. and Hong, Z. and Zheng, H. and others},
  title   = {{TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02741-w},
  pmid    = {36829205},
  url     = {https://doi.org/10.1186/s12974-023-02741-w}
}

@article{tran2023-36803190,
  author  = {Tran, K. M. and Kawauchi, S. and Kramár, E. A. and Rezaie, N. and Liang, H. Y. and Sakr, J. S. and Gomez-Arboledas, A. and Arreola, M. A. and others},
  title   = {{A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00598-4},
  pmid    = {36803190},
  url     = {https://doi.org/10.1186/s13024-023-00598-4}
}

@article{peng2023-36662361,
  author  = {Peng, X. and Guo, H. and Zhang, X. and Yang, Z. and Ruganzu, J. B. and Wu, X. and Bi, W. and others},
  title   = {{TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-023-03217-x},
  pmid    = {36662361},
  url     = {https://doi.org/10.1007/s12035-023-03217-x}
}

@article{liebold2023-36766683,
  author  = {Liebold, I. and Meyer, S. and Heine, M. and Kuhl, A. and Witt, J. and Eissing, L. and Fischer, A. W. and Koop, A. C. and others},
  title   = {{TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD}},
  journal = {Cells},
  year    = {2023},
  doi     = {10.3390/cells12030341},
  pmid    = {36766683},
  url     = {https://doi.org/10.3390/cells12030341}
}

@article{vanlengerich2023-36635496,
  author  = {van Lengerich, B. and Zhan, L. and Xia, D. and Chan, D. and Joy, D. and Park, J. I. and Tatarakis, D. and Calvert, M. and others},
  title   = {{A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models}},
  journal = {Nature neuroscience},
  year    = {2023},
  doi     = {10.1038/s41593-022-01240-0},
  pmid    = {36635496},
  url     = {https://doi.org/10.1038/s41593-022-01240-0}
}

@article{zhang2023-36635449,
  author  = {Zhang, K. and Wang, Y. and Chen, S. and Mao, J. and Jin, Y. and Ye, H. and Zhang, Y. and Liu, X. and others},
  title   = {{TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis}},
  journal = {Nature metabolism},
  year    = {2023},
  doi     = {10.1038/s42255-022-00715-5},
  pmid    = {36635449},
  url     = {https://doi.org/10.1038/s42255-022-00715-5}
}

@article{biel2023-36620941,
  author  = {Biel, D. and Suárez-Calvet, M. and Hager, P. and Rubinski, A. and Dewenter, A. and Steward, A. and Roemer, S. and Ewers, M. and others},
  title   = {{sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease}},
  journal = {EMBO molecular medicine},
  year    = {2023},
  doi     = {10.15252/emmm.202216987},
  pmid    = {36620941},
  url     = {https://doi.org/10.15252/emmm.202216987}
}

@article{hou2022-36564824,
  author  = {Hou, J. and Chen, Y. and Grajales-Reyes, G. and Colonna, M.},
  title   = {{TREM2 dependent and independent functions of microglia in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00588-y},
  pmid    = {36564824},
  url     = {https://doi.org/10.1186/s13024-022-00588-y}
}

@article{zhao2022-36519540,
  author  = {Zhao, A. and Jiao, Y. and Ye, G. and Kang, W. and Tan, L. and Li, Y. and Deng, Y. and Liu, J. and others},
  title   = {{Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease}},
  journal = {The Journal of clinical investigation},
  year    = {2022},
  doi     = {10.1172/jci158708},
  pmid    = {36519540},
  url     = {https://doi.org/10.1172/jci158708}
}

@article{wang2023-36521495,
  author  = {Wang, X. and He, Q. and Zhou, C. and Xu, Y. and Liu, D. and Fujiwara, N. and Kubota, N. and Click, A. and others},
  title   = {{Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development}},
  journal = {Immunity},
  year    = {2023},
  doi     = {10.1016/j.immuni.2022.11.013},
  pmid    = {36521495},
  url     = {https://doi.org/10.1016/j.immuni.2022.11.013}
}

@article{yang2023-36259513,
  author  = {Yang, T. and Zhang, S. and Yuan, H. and Wang, Y. and Cai, L. and Chen, H. and Wang, X. and Song, D. and others},
  title   = {{Platinum-Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2023},
  doi     = {10.1002/anie.202213337},
  pmid    = {36259513},
  url     = {https://doi.org/10.1002/anie.202213337}
}

@article{rikos2024-36408688,
  author  = {Rikos, D. and Siokas, V. and Mentis, A. A. and Aloizou, A. M. and Liampas, I. and Tsouris, Z. and Peristeri, E. and Stamati, P. and others},
  title   = {{TREM2 R47H variant and risk for Alzheimer's disease: assessment in a Greek population and updated meta-analysis}},
  journal = {The International journal of neuroscience},
  year    = {2024},
  doi     = {10.1080/00207454.2022.2150844},
  pmid    = {36408688},
  url     = {https://doi.org/10.1080/00207454.2022.2150844}
}

@article{yan2022-36463233,
  author  = {Yan, J. and Zhang, Y. and Wang, L. and Li, Z. and Tang, S. and Wang, Y. and Gu, N. and Sun, X. and others},
  title   = {{TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02651-3},
  pmid    = {36463233},
  url     = {https://doi.org/10.1186/s12974-022-02651-3}
}

@article{gratuze2023-36368315,
  author  = {Gratuze, M. and Schlachetzki, J. C. M. and D'Oliveira Albanus, R. and Jain, N. and Novotny, B. and Brase, L. and Rodriguez, L. and Mansel, C. and others},
  title   = {{TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4}},
  journal = {Neuron},
  year    = {2023},
  doi     = {10.1016/j.neuron.2022.10.022},
  pmid    = {36368315},
  url     = {https://doi.org/10.1016/j.neuron.2022.10.022}
}

@article{wood2022-36417868,
  author  = {Wood, J. I. and Wong, E. and Joghee, R. and Balbaa, A. and Vitanova, K. S. and Stringer, K. M. and Vanshoiack, A. and Phelan, S. J. and others},
  title   = {{Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology}},
  journal = {Cell reports},
  year    = {2022},
  doi     = {10.1016/j.celrep.2022.111686},
  pmid    = {36417868},
  url     = {https://doi.org/10.1016/j.celrep.2022.111686}
}

@article{he2022-36316319,
  author  = {He, L. and Zheng, Y. and Huang, L. and Ye, J. and Ye, Y. and Luo, H. and Chen, X. and Yao, W. and others},
  title   = {{Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice}},
  journal = {Translational psychiatry},
  year    = {2022},
  doi     = {10.1038/s41398-022-02227-y},
  pmid    = {36316319},
  url     = {https://doi.org/10.1038/s41398-022-02227-y}
}

@article{satohasahara2022-36272585,
  author  = {Satoh-Asahara, N. and Yamakage, H. and Tanaka, M. and Kawasaki, T. and Matsuura, S. and Tatebe, H. and Akiguchi, I. and Tokuda, T.},
  title   = {{Soluble TREM2 and Alzheimer-related biomarker trajectories in the blood of patients with diabetes based on their cognitive status}},
  journal = {Diabetes research and clinical practice},
  year    = {2022},
  doi     = {10.1016/j.diabres.2022.110121},
  pmid    = {36272585},
  url     = {https://doi.org/10.1016/j.diabres.2022.110121}
}

@article{jain2023-36219197,
  author  = {Jain, N. and Lewis, C. A. and Ulrich, J. D. and Holtzman, D. M.},
  title   = {{Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading}},
  journal = {The Journal of experimental medicine},
  year    = {2023},
  doi     = {10.1084/jem.20220654},
  pmid    = {36219197},
  url     = {https://doi.org/10.1084/jem.20220654}
}

@article{wang2022-36306735,
  author  = {Wang, S. and Sudan, R. and Peng, V. and Zhou, Y. and Du, S. and Yuede, C. M. and Lei, T. and Hou, J. and others},
  title   = {{TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways}},
  journal = {Cell},
  year    = {2022},
  doi     = {10.1016/j.cell.2022.09.033},
  pmid    = {36306735},
  url     = {https://doi.org/10.1016/j.cell.2022.09.033}
}

@article{zhao2022-36107206,
  author  = {Zhao, N. and Qiao, W. and Li, F. and Ren, Y. and Zheng, J. and Martens, Y. A. and Wang, X. and Li, L. and others},
  title   = {{Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia}},
  journal = {The Journal of experimental medicine},
  year    = {2022},
  doi     = {10.1084/jem.20212479},
  pmid    = {36107206},
  url     = {https://doi.org/10.1084/jem.20212479}
}

@article{zhao2022-36070367,
  author  = {Zhao, P. and Xu, Y. and Jiang, L. and Fan, X. and Li, L. and Li, X. and Arase, H. and Zhao, Y. and others},
  title   = {{A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease}},
  journal = {Science translational medicine},
  year    = {2022},
  doi     = {10.1126/scitranslmed.abq0095},
  pmid    = {36070367},
  url     = {https://doi.org/10.1126/scitranslmed.abq0095}
}

@article{wang2022-36068223,
  author  = {Wang, Y. and Cao, C. and Zhu, Y. and Fan, H. and Liu, Q. and Liu, Y. and Chen, K. and Wu, Y. and others},
  title   = {{TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria}},
  journal = {Cell death \& disease},
  year    = {2022},
  doi     = {10.1038/s41419-022-05193-x},
  pmid    = {36068223},
  url     = {https://doi.org/10.1038/s41419-022-05193-x}
}

@article{zhu2022-36056435,
  author  = {Zhu, B. and Liu, Y. and Hwang, S. and Archuleta, K. and Huang, H. and Campos, A. and Murad, R. and Piña-Crespo, J. and others},
  title   = {{Trem2 deletion enhances tau dispersion and pathology through microglia exosomes}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00562-8},
  pmid    = {36056435},
  url     = {https://doi.org/10.1186/s13024-022-00562-8}
}

@article{han2022-36041498,
  author  = {Han, X. and Cheng, X. and Xu, J. and Liu, Y. and Zhou, J. and Jiang, L. and Gu, X. and Xia, T.},
  title   = {{Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice}},
  journal = {Neuropharmacology},
  year    = {2022},
  doi     = {10.1016/j.neuropharm.2022.109231},
  pmid    = {36041498},
  url     = {https://doi.org/10.1016/j.neuropharm.2022.109231}
}

@article{hauremirande2022-36002854,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Ehrlich, M. E. and Gandy, S.},
  title   = {{Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00552-w},
  pmid    = {36002854},
  url     = {https://doi.org/10.1186/s13024-022-00552-w}
}

@article{jung2022-35933399,
  author  = {Jung, S. H. and Hwang, B. H. and Shin, S. and Park, E. H. and Park, S. H. and Kim, C. W. and Kim, E. and Choo, E. and others},
  title   = {{Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts}},
  journal = {Nature communications},
  year    = {2022},
  doi     = {10.1038/s41467-022-32284-2},
  pmid    = {35933399},
  url     = {https://doi.org/10.1038/s41467-022-32284-2}
}

@article{dabla2022-35924849,
  author  = {Dabla, A. and Liang, Y. C. and Rajabalee, N. and Irwin, C. and Moonen, C. G. J. and Willis, J. V. and Berton, S. and Sun, J.},
  title   = {{TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages}},
  journal = {mBio},
  year    = {2022},
  doi     = {10.1128/mbio.01456-22},
  pmid    = {35924849},
  url     = {https://doi.org/10.1128/mbio.01456-22}
}

@article{do2022-35867799,
  author  = {Do, T. H. and Ma, F. and Andrade, P. R. and Teles, R. and de Andrade Silva, B. J. and Hu, C. and Espinoza, A. and Hsu, J. E. and others},
  title   = {{TREM2 macrophages induced by human lipids drive inflammation in acne lesions}},
  journal = {Science immunology},
  year    = {2022},
  doi     = {10.1126/sciimmunol.abo2787},
  pmid    = {35867799},
  url     = {https://doi.org/10.1126/sciimmunol.abo2787}
}

@article{indirachandran2023-35712786,
  author  = {Indira Chandran, V. and Wernberg, C. W. and Lauridsen, M. M. and Skytthe, M. K. and Bendixen, S. M. and Larsen, F. T. and Hansen, C. D. and Grønkjær, L. L. and others},
  title   = {{Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness}},
  journal = {Hepatology (Baltimore, Md.)},
  year    = {2023},
  doi     = {10.1002/hep.32620},
  pmid    = {35712786},
  url     = {https://doi.org/10.1002/hep.32620}
}

@article{fracassi2023-35816404,
  author  = {Fracassi, A. and Marcatti, M. and Tumurbaatar, B. and Woltjer, R. and Moreno, S. and Taglialatela, G.},
  title   = {{TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2023},
  doi     = {10.1111/bpa.13108},
  pmid    = {35816404},
  url     = {https://doi.org/10.1111/bpa.13108}
}

@article{hendrikx2022-35750138,
  author  = {Hendrikx, T. and Porsch, F. and Kiss, M. G. and Rajcic, D. and Papac-Miličević, N. and Hoebinger, C. and Goederle, L. and Hladik, A. and others},
  title   = {{Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH}},
  journal = {Journal of hepatology},
  year    = {2022},
  doi     = {10.1016/j.jhep.2022.06.004},
  pmid    = {35750138},
  url     = {https://doi.org/10.1016/j.jhep.2022.06.004}
}

@article{zhao2022-35717259,
  author  = {Zhao, P. and Xu, Y. and Jiang, L. L. and Fan, X. and Ku, Z. and Li, L. and Liu, X. and Deng, M. and others},
  title   = {{LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00550-y},
  pmid    = {35717259},
  url     = {https://doi.org/10.1186/s13024-022-00550-y}
}

@article{khantakova2022-35746551,
  author  = {Khantakova, D. and Brioschi, S. and Molgora, M.},
  title   = {{Exploring the Impact of TREM2 in Tumor-Associated Macrophages}},
  journal = {Vaccines},
  year    = {2022},
  doi     = {10.3390/vaccines10060943},
  pmid    = {35746551},
  url     = {https://doi.org/10.3390/vaccines10060943}
}

@article{shi2022-35672148,
  author  = {Shi, Q. and Chang, C. and Saliba, A. and Bhat, M. A.},
  title   = {{Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2022},
  doi     = {10.1523/jneurosci.2427-21.2022},
  pmid    = {35672148},
  url     = {https://doi.org/10.1523/jneurosci.2427-21.2022}
}

@article{li2022-35658903,
  author  = {Li, R. Y. and Qin, Q. and Yang, H. C. and Wang, Y. Y. and Mi, Y. X. and Yin, Y. S. and Wang, M. and Yu, C. J. and others},
  title   = {{TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00542-y},
  pmid    = {35658903},
  url     = {https://doi.org/10.1186/s13024-022-00542-y}
}

@article{morenasrodriguez2022-35305339,
  author  = {Morenas-Rodríguez, E. and Li, Y. and Nuscher, B. and Franzmeier, N. and Xiong, C. and Suárez-Calvet, M. and Fagan, A. M. and Schultz, S. and others},
  title   = {{Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study}},
  journal = {The Lancet. Neurology},
  year    = {2022},
  doi     = {10.1016/s1474-4422(22)00027-8},
  pmid    = {35305339},
  url     = {https://doi.org/10.1016/s1474-4422(22)00027-8}
}

@article{zhou2022-35359989,
  author  = {Zhou, L. and Wang, M. and Guo, H. and Hou, J. and Zhang, Y. and Li, M. and Wu, X. and Chen, X. and others},
  title   = {{Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.848367},
  pmid    = {35359989},
  url     = {https://doi.org/10.3389/fimmu.2022.848367}
}

@article{zhang2022-35278107,
  author  = {Zhang, H. and Liu, Z. and Wen, H. and Guo, Y. and Xu, F. and Zhu, Q. and Yuan, W. and Luo, R. and others},
  title   = {{Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer}},
  journal = {Cancer immunology, immunotherapy : CII},
  year    = {2022},
  doi     = {10.1007/s00262-022-03173-w},
  pmid    = {35278107},
  url     = {https://doi.org/10.1007/s00262-022-03173-w}
}

@article{jairaman2022-35191835,
  author  = {Jairaman, A. and McQuade, A. and Granzotto, A. and Kang, Y. J. and Chadarevian, J. P. and Gandhi, S. and Parker, I. and Smith, I. and others},
  title   = {{TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia}},
  journal = {eLife},
  year    = {2022},
  doi     = {10.7554/elife.73021},
  pmid    = {35191835},
  url     = {https://doi.org/10.7554/elife.73021}
}

@article{belsare2022-35082148,
  author  = {Belsare, K. D. and Wu, H. and Mondal, D. and Bond, A. and Castillo, E. and Jin, J. and Jo, H. and Roush, A. E. and others},
  title   = {{Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2022},
  doi     = {10.1073/pnas.2114486119},
  pmid    = {35082148},
  url     = {https://doi.org/10.1073/pnas.2114486119}
}

@article{filipello2022-35041990,
  author  = {Filipello, F. and Goldsbury, C. and You, S. F. and Locca, A. and Karch, C. M. and Piccio, L.},
  title   = {{Soluble TREM2: Innocent bystander or active player in neurological diseases?}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105630},
  pmid    = {35041990},
  url     = {https://doi.org/10.1016/j.nbd.2022.105630}
}

@article{reifschneider2022-35019161,
  author  = {Reifschneider, A. and Robinson, S. and van Lengerich, B. and Gnörich, J. and Logan, T. and Heindl, S. and Vogt, M. A. and Weidinger, E. and others},
  title   = {{Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency}},
  journal = {The EMBO journal},
  year    = {2022},
  doi     = {10.15252/embj.2021109108},
  pmid    = {35019161},
  url     = {https://doi.org/10.15252/embj.2021109108}
}

@article{ruganzu2022-34959070,
  author  = {Ruganzu, J. B. and Peng, X. and He, Y. and Wu, X. and Zheng, Q. and Ding, B. and Lin, C. and Guo, H. and others},
  title   = {{Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease}},
  journal = {Molecular immunology},
  year    = {2022},
  doi     = {10.1016/j.molimm.2021.12.018},
  pmid    = {34959070},
  url     = {https://doi.org/10.1016/j.molimm.2021.12.018}
}

@article{xie2022-34916658,
  author  = {Xie, M. and Liu, Y. U. and Zhao, S. and Zhang, L. and Bosco, D. B. and Pang, Y. P. and Zhong, J. and Sheth, U. and others},
  title   = {{TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration}},
  journal = {Nature neuroscience},
  year    = {2022},
  doi     = {10.1038/s41593-021-00975-6},
  pmid    = {34916658},
  url     = {https://doi.org/10.1038/s41593-021-00975-6}
}

@article{sayed2021-34851693,
  author  = {Sayed, F. A. and Kodama, L. and Fan, L. and Carling, G. K. and Udeochu, J. C. and Le, D. and Li, Q. and Zhou, L. and others},
  title   = {{AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation}},
  journal = {Science translational medicine},
  year    = {2021},
  doi     = {10.1126/scitranslmed.abe3947},
  pmid    = {34851693},
  url     = {https://doi.org/10.1126/scitranslmed.abe3947}
}

@article{lee2021-34965428,
  author  = {Lee, S. H. and Rezzonico, M. G. and Friedman, B. A. and Huntley, M. H. and Meilandt, W. J. and Pandey, S. and Chen, Y. J. and Easton, A. and others},
  title   = {{TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.110158},
  pmid    = {34965428},
  url     = {https://doi.org/10.1016/j.celrep.2021.110158}
}

@article{henn2021-34851663,
  author  = {Henn, D. and Chen, K. and Fehlmann, T. and Trotsyuk, A. A. and Sivaraj, D. and Maan, Z. N. and Bonham, C. A. and Barrera, J. A. and others},
  title   = {{Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2+ macrophages}},
  journal = {Science advances},
  year    = {2021},
  doi     = {10.1126/sciadv.abi4528},
  pmid    = {34851663},
  url     = {https://doi.org/10.1126/sciadv.abi4528}
}

@article{lichtenthaler2022-34689040,
  author  = {Lichtenthaler, S. F. and Tschirner, S. K. and Steiner, H.},
  title   = {{Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2}},
  journal = {Current opinion in neurobiology},
  year    = {2022},
  doi     = {10.1016/j.conb.2021.09.003},
  pmid    = {34689040},
  url     = {https://doi.org/10.1016/j.conb.2021.09.003}
}

@article{xue2022-35847502,
  author  = {Xue, T. and Ji, J. and Sun, Y. and Huang, X. and Cai, Z. and Yang, J. and Guo, W. and Guo, R. and others},
  title   = {{Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury}},
  journal = {Acta pharmaceutica Sinica. B},
  year    = {2022},
  doi     = {10.1016/j.apsb.2021.10.012},
  pmid    = {35847502},
  url     = {https://doi.org/10.1016/j.apsb.2021.10.012}
}

@article{kotredes2021-34707490,
  author  = {Kotredes, K. P. and Oblak, A. and Pandey, R. S. and Lin, P. B. and Garceau, D. and Williams, H. and Uyar, A. and O'Rourke, R. and others},
  title   = {{Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.735524},
  pmid    = {34707490},
  url     = {https://doi.org/10.3389/fnagi.2021.735524}
}

@article{binnewies2021-34686340,
  author  = {Binnewies, M. and Pollack, J. L. and Rudolph, J. and Dash, S. and Abushawish, M. and Lee, T. and Jahchan, N. S. and Canaday, P. and others},
  title   = {{Targeting TREM2 on tumor-associated macrophages enhances immunotherapy}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.109844},
  pmid    = {34686340},
  url     = {https://doi.org/10.1016/j.celrep.2021.109844}
}

@article{gouna2021-34424266,
  author  = {Gouna, G. and Klose, C. and Bosch-Queralt, M. and Liu, L. and Gokce, O. and Schifferer, M. and Cantuti-Castelvetri, L. and Simons, M.},
  title   = {{TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination}},
  journal = {The Journal of experimental medicine},
  year    = {2021},
  doi     = {10.1084/jem.20210227},
  pmid    = {34424266},
  url     = {https://doi.org/10.1084/jem.20210227}
}

@article{schoch2021-34187891,
  author  = {Schoch, K. M. and Ezerskiy, L. A. and Morhaus, M. M. and Bannon, R. N. and Sauerbeck, A. D. and Shabsovich, M. and Jafar-Nejad, P. and Rigo, F. and others},
  title   = {{Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2100356118},
  pmid    = {34187891},
  url     = {https://doi.org/10.1073/pnas.2100356118}
}

@article{iizasa2021-33863908,
  author  = {Iizasa, E. and Chuma, Y. and Uematsu, T. and Kubota, M. and Kawaguchi, H. and Umemura, M. and Toyonaga, K. and Kiyohara, H. and others},
  title   = {{TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-22620-3},
  pmid    = {33863908},
  url     = {https://doi.org/10.1038/s41467-021-22620-3}
}

@article{lee2021-33675684,
  author  = {Lee, S. H. and Meilandt, W. J. and Xie, L. and Gandham, V. D. and Ngu, H. and Barck, K. H. and Rezzonico, M. G. and Imperio, J. and others},
  title   = {{Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2021.02.010},
  pmid    = {33675684},
  url     = {https://doi.org/10.1016/j.neuron.2021.02.010}
}

@article{schindler2021-33884297,
  author  = {Schindler, S. E. and Cruchaga, C. and Joseph, A. and McCue, L. and Farias, F. H. G. and Wilkins, C. H. and Deming, Y. and Henson, R. L. and others},
  title   = {{African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants}},
  journal = {Neurology. Genetics},
  year    = {2021},
  doi     = {10.1212/nxg.0000000000000571},
  pmid    = {33884297},
  url     = {https://doi.org/10.1212/nxg.0000000000000571}
}

@article{sharif2021-33627323,
  author  = {Sharif, O. and Brunner, J. S. and Korosec, A. and Martins, R. and Jais, A. and Snijder, B. and Vogel, A. and Caldera, M. and others},
  title   = {{Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages}},
  journal = {Diabetes},
  year    = {2021},
  doi     = {10.2337/db20-0572},
  pmid    = {33627323},
  url     = {https://doi.org/10.2337/db20-0572}
}

@article{cheng2021-33679809,
  author  = {Cheng, X. and Wang, X. and Nie, K. and Cheng, L. and Zhang, Z. and Hu, Y. and Peng, W.},
  title   = {{Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.646523},
  pmid    = {33679809},
  url     = {https://doi.org/10.3389/fimmu.2021.646523}
}

@article{reich2020-33613545,
  author  = {Reich, M. and Paris, I. and Ebeling, M. and Dahm, N. and Schweitzer, C. and Reinhardt, D. and Schmucki, R. and Prasad, M. and others},
  title   = {{Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.617860},
  pmid    = {33613545},
  url     = {https://doi.org/10.3389/fimmu.2020.617860}
}

@article{hou2021-33586673,
  author  = {Hou, J. and Zhang, J. and Cui, P. and Zhou, Y. and Liu, C. and Wu, X. and Ji, Y. and Wang, S. and others},
  title   = {{TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis}},
  journal = {The Journal of clinical investigation},
  year    = {2021},
  doi     = {10.1172/jci135197},
  pmid    = {33586673},
  url     = {https://doi.org/10.1172/jci135197}
}

@article{qin2021-33516818,
  author  = {Qin, Q. and Teng, Z. and Liu, C. and Li, Q. and Yin, Y. and Tang, Y.},
  title   = {{TREM2, microglia, and Alzheimer's disease}},
  journal = {Mechanisms of ageing and development},
  year    = {2021},
  doi     = {10.1016/j.mad.2021.111438},
  pmid    = {33516818},
  url     = {https://doi.org/10.1016/j.mad.2021.111438}
}

@article{akhter2021-33461764,
  author  = {Akhter, R. and Shao, Y. and Formica, S. and Khrestian, M. and Bekris, L. M.},
  title   = {{TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells}},
  journal = {Molecular immunology},
  year    = {2021},
  doi     = {10.1016/j.molimm.2020.12.035},
  pmid    = {33461764},
  url     = {https://doi.org/10.1016/j.molimm.2020.12.035}
}

@article{fassler2021-33422057,
  author  = {Fassler, M. and Rappaport, M. S. and Cuño, C. B. and George, J.},
  title   = {{Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-020-01980-5},
  pmid    = {33422057},
  url     = {https://doi.org/10.1186/s12974-020-01980-5}
}

@article{ellwanger2021-33446504,
  author  = {Ellwanger, D. C. and Wang, S. and Brioschi, S. and Shao, Z. and Green, L. and Case, R. and Yoo, D. and Weishuhn, D. and others},
  title   = {{Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2017742118},
  pmid    = {33446504},
  url     = {https://doi.org/10.1073/pnas.2017742118}
}

@article{vilalta2021-33823153,
  author  = {Vilalta, A. and Zhou, Y. and Sevalle, J. and Griffin, J. K. and Satoh, K. and Allendorf, D. H. and De, S. and Puigdellívol, M. and others},
  title   = {{Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation}},
  journal = {The Journal of biological chemistry},
  year    = {2021},
  doi     = {10.1016/j.jbc.2021.100631},
  pmid    = {33823153},
  url     = {https://doi.org/10.1016/j.jbc.2021.100631}
}

@article{weng2021-33486152,
  author  = {Weng, Y. and Wang, H. and Li, L. and Feng, Y. and Xu, S. and Wang, Z.},
  title   = {{Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment}},
  journal = {Redox biology},
  year    = {2021},
  doi     = {10.1016/j.redox.2020.101849},
  pmid    = {33486152},
  url     = {https://doi.org/10.1016/j.redox.2020.101849}
}

@article{audrain2021-33314529,
  author  = {Audrain, M. and Haure-Mirande, J. V. and Mleczko, J. and Wang, M. and Griffin, J. K. and St George-Hyslop, P. H. and Fraser, P. and Zhang, B. and others},
  title   = {{Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12256},
  pmid    = {33314529},
  url     = {https://doi.org/10.1002/alz.12256}
}

@article{sun2020-33297569,
  author  = {Sun, H. and Feng, J. and Tang, L.},
  title   = {{Function of TREM1 and TREM2 in Liver-Related Diseases}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9122626},
  pmid    = {33297569},
  url     = {https://doi.org/10.3390/cells9122626}
}

@article{hallroberts2020-33198789,
  author  = {Hall-Roberts, H. and Agarwal, D. and Obst, J. and Smith, T. B. and Monzón-Sandoval, J. and Di Daniel, E. and Webber, C. and James, W. S. and others},
  title   = {{TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00709-z},
  pmid    = {33198789},
  url     = {https://doi.org/10.1186/s13195-020-00709-z}
}

@article{qu2020-33139402,
  author  = {Qu, W. and Li, L.},
  title   = {{Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.2193-20.2020},
  pmid    = {33139402},
  url     = {https://doi.org/10.1523/jneurosci.2193-20.2020}
}

@article{liu2020-32959884,
  author  = {Liu, W. and Taso, O. and Wang, R. and Bayram, S. and Graham, A. C. and Garcia-Reitboeck, P. and Mallach, A. and Andrews, W. D. and others},
  title   = {{Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions}},
  journal = {Human molecular genetics},
  year    = {2020},
  doi     = {10.1093/hmg/ddaa209},
  pmid    = {32959884},
  url     = {https://doi.org/10.1093/hmg/ddaa209}
}

@article{jadhav2020-33115519,
  author  = {Jadhav, V. S. and Lin, P. B. C. and Pennington, T. and Di Prisco, G. V. and Jannu, A. J. and Xu, G. and Moutinho, M. and Zhang, J. and others},
  title   = {{Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00409-0},
  pmid    = {33115519},
  url     = {https://doi.org/10.1186/s13024-020-00409-0}
}

@article{mcquade2020-33097708,
  author  = {McQuade, A. and Kang, Y. J. and Hasselmann, J. and Jairaman, A. and Sotelo, A. and Coburn, M. and Shabestari, S. K. and Chadarevian, J. P. and others},
  title   = {{Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-19227-5},
  pmid    = {33097708},
  url     = {https://doi.org/10.1038/s41467-020-19227-5}
}

@article{wang2020-33065553,
  author  = {Wang, Y. and Lin, Y. and Wang, L. and Zhan, H. and Luo, X. and Zeng, Y. and Wu, W. and Zhang, X. and others},
  title   = {{TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice}},
  journal = {Aging},
  year    = {2020},
  doi     = {10.18632/aging.104104},
  pmid    = {33065553},
  url     = {https://doi.org/10.18632/aging.104104}
}

@article{ruganzu2021-33065077,
  author  = {Ruganzu, J. B. and Zheng, Q. and Wu, X. and He, Y. and Peng, X. and Jin, H. and Zhou, J. and Ma, R. and others},
  title   = {{TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway}},
  journal = {Experimental neurology},
  year    = {2021},
  doi     = {10.1016/j.expneurol.2020.113506},
  pmid    = {33065077},
  url     = {https://doi.org/10.1016/j.expneurol.2020.113506}
}

@article{xiong2020-33033253,
  author  = {Xiong, D. and Wang, Y. and You, M.},
  title   = {{A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-18546-x},
  pmid    = {33033253},
  url     = {https://doi.org/10.1038/s41467-020-18546-x}
}

@article{kober2020-33090700,
  author  = {Kober, D. L. and Stuchell-Brereton, M. D. and Kluender, C. E. and Dean, H. B. and Strickland, M. R. and Steinberg, D. F. and Nelson, S. S. and Baban, B. and others},
  title   = {{Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12194},
  pmid    = {33090700},
  url     = {https://doi.org/10.1002/alz.12194}
}

@article{franzmeier2020-33032659,
  author  = {Franzmeier, N. and Suárez-Calvet, M. and Frontzkowski, L. and Moore, A. and Hohman, T. J. and Morenas-Rodriguez, E. and Nuscher, B. and Shaw, L. and others},
  title   = {{Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00407-2},
  pmid    = {33032659},
  url     = {https://doi.org/10.1186/s13024-020-00407-2}
}

@article{wang2020-32579671,
  author  = {Wang, S. and Mustafa, M. and Yuede, C. M. and Salazar, S. V. and Kong, P. and Long, H. and Ward, M. and Siddiqui, O. and others},
  title   = {{Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model}},
  journal = {The Journal of experimental medicine},
  year    = {2020},
  doi     = {10.1084/jem.20200785},
  pmid    = {32579671},
  url     = {https://doi.org/10.1084/jem.20200785}
}

@article{gratuze2020-32544086,
  author  = {Gratuze, M. and Leyns, C. E. and Sauerbeck, A. D. and St-Pierre, M. K. and Xiong, M. and Kim, N. and Serrano, JR. and MÈ, Tremblay and others},
  title   = {{Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration}},
  journal = {The Journal of clinical investigation},
  year    = {2020},
  doi     = {10.1172/jci138179},
  pmid    = {32544086},
  url     = {https://doi.org/10.1172/jci138179}
}

@article{nguyen2020-32840654,
  author  = {Nguyen, A. T. and Wang, K. and Hu, G. and Wang, X. and Miao, Z. and Azevedo, J. A. and Suh, E. and Van Deerlin, V. M. and others},
  title   = {{APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02200-3},
  pmid    = {32840654},
  url     = {https://doi.org/10.1007/s00401-020-02200-3}
}

@article{price2020-32795308,
  author  = {Price, B. R. and Sudduth, T. L. and Weekman, E. M. and Johnson, S. and Hawthorne, D. and Woolums, A. and Wilcock, D. M.},
  title   = {{Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01915-0},
  pmid    = {32795308},
  url     = {https://doi.org/10.1186/s12974-020-01915-0}
}

@article{katzenelenbogen2020-32783915,
  author  = {Katzenelenbogen, Y. and Sheban, F. and Yalin, A. and Yofe, I. and Svetlichnyy, D. and Jaitin, D. A. and Bornstein, C. and Moshe, A. and others},
  title   = {{Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.06.032},
  pmid    = {32783915},
  url     = {https://doi.org/10.1016/j.cell.2020.06.032}
}

@article{molgora2020-32783918,
  author  = {Molgora, M. and Esaulova, E. and Vermi, W. and Hou, J. and Chen, Y. and Luo, J. and Brioschi, S. and Bugatti, M. and others},
  title   = {{TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.07.013},
  pmid    = {32783918},
  url     = {https://doi.org/10.1016/j.cell.2020.07.013}
}

@article{cignarella2020-32772264,
  author  = {Cignarella, F. and Filipello, F. and Bollman, B. and Cantoni, C. and Locca, A. and Mikesell, R. and Manis, M. and Ibrahim, A. and others},
  title   = {{TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02193-z},
  pmid    = {32772264},
  url     = {https://doi.org/10.1007/s00401-020-02193-z}
}

@article{taylor2020-32711525,
  author  = {Taylor, X. and Cisternas, P. and You, Y. and Xiang, S. and Marambio, Y. and Zhang, J. and Vidal, R. and others},
  title   = {{A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01900-7},
  pmid    = {32711525},
  url     = {https://doi.org/10.1186/s12974-020-01900-7}
}

@article{fitz2020-32703241,
  author  = {Fitz, N. F. and Wolfe, C. M. and Playso, B. E. and Biedrzycki, R. J. and Lu, Y. and Nam, K. N. and Lefterov, I. and Koldamova, R.},
  title   = {{Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00394-4},
  pmid    = {32703241},
  url     = {https://doi.org/10.1186/s13024-020-00394-4}
}

@article{yang2020-32635934,
  author  = {Yang, J. and Fu, Z. and Zhang, X. and Xiong, M. and Meng, L. and Zhang, Z.},
  title   = {{TREM2 ectodomain and its soluble form in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01878-2},
  pmid    = {32635934},
  url     = {https://doi.org/10.1186/s12974-020-01878-2}
}

@article{ren2020-32579116,
  author  = {Ren, S. and Yao, W. and Tambini, M. D. and Yin, T. and Norris, K. A. and D'Adamio, L.},
  title   = {{Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels}},
  journal = {eLife},
  year    = {2020},
  doi     = {10.7554/elife.57513},
  pmid    = {32579116},
  url     = {https://doi.org/10.7554/elife.57513}
}

@article{andreone2020-32514138,
  author  = {Andreone, B. J. and Przybyla, L. and Llapashtica, C. and Rana, A. and Davis, S. S. and van Lengerich, B. and Lin, K. and Shi, J. and others},
  title   = {{Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia}},
  journal = {Nature neuroscience},
  year    = {2020},
  doi     = {10.1038/s41593-020-0650-6},
  pmid    = {32514138},
  url     = {https://doi.org/10.1038/s41593-020-0650-6}
}

@article{deczkowska2020-32531244,
  author  = {Deczkowska, A. and Weiner, A. and Amit, I.},
  title   = {{The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.05.003},
  pmid    = {32531244},
  url     = {https://doi.org/10.1016/j.cell.2020.05.003}
}

@article{chen2020-32466767,
  author  = {Chen, S. and Peng, J. and Sherchan, P. and Ma, Y. and Xiang, S. and Yan, F. and Zhao, H. and Jiang, Y. and others},
  title   = {{TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01853-x},
  pmid    = {32466767},
  url     = {https://doi.org/10.1186/s12974-020-01853-x}
}

@article{wu2022-35224156,
  author  = {Wu, M. and Liao, M. and Huang, R. and Chen, C. and Tian, T. and Wang, H. and Li, J. and others},
  title   = {{Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia}},
  journal = {Genes \& diseases},
  year    = {2022},
  doi     = {10.1016/j.gendis.2020.05.005},
  pmid    = {35224156},
  url     = {https://doi.org/10.1016/j.gendis.2020.05.005}
}

@article{zhu2020-32401783,
  author  = {Zhu, Z. and Zhang, X. and Dong, W. and Wang, X. and He, S. and Zhang, H. and Wei, R. and others},
  title   = {{TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling}},
  journal = {PLoS pathogens},
  year    = {2020},
  doi     = {10.1371/journal.ppat.1008543},
  pmid    = {32401783},
  url     = {https://doi.org/10.1371/journal.ppat.1008543}
}

@article{ma2020-32276587,
  author  = {Ma, L. Z. and Tan, L. and Bi, Y. L. and Shen, X. N. and Xu, W. and Ma, Y. H. and Li, H. Q. and Dong, Q. and others},
  title   = {{Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00374-8},
  pmid    = {32276587},
  url     = {https://doi.org/10.1186/s13024-020-00374-8}
}

@article{kleineidam2020-32166339,
  author  = {Kleineidam, L. and Chouraki, V. and Próchnicki, T. and van der Lee, S. J. and Madrid-Márquez, L. and Wagner-Thelen, H. and Karaca, I. and Weinhold, L. and others},
  title   = {{PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02138-6},
  pmid    = {32166339},
  url     = {https://doi.org/10.1007/s00401-020-02138-6}
}

@article{schlepckow2020-32154671,
  author  = {Schlepckow, K. and Monroe, K. M. and Kleinberger, G. and Cantuti-Castelvetri, L. and Parhizkar, S. and Xia, D. and Willem, M. and Werner, G. and others},
  title   = {{Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region}},
  journal = {EMBO molecular medicine},
  year    = {2020},
  doi     = {10.15252/emmm.201911227},
  pmid    = {32154671},
  url     = {https://doi.org/10.15252/emmm.201911227}
}

@article{wilson2020-32065223,
  author  = {Wilson, E. N. and Swarovski, M. S. and Linortner, P. and Shahid, M. and Zuckerman, A. J. and Wang, Q. and Channappa, D. and Minhas, P. S. and others},
  title   = {{Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awaa021},
  pmid    = {32065223},
  url     = {https://doi.org/10.1093/brain/awaa021}
}

@article{meilandt2020-31980586,
  author  = {Meilandt, W. J. and Ngu, H. and Gogineni, A. and Lalehzadeh, G. and Lee, S. H. and Srinivasan, K. and Imperio, J. and Wu, T. and others},
  title   = {{Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.1871-19.2019},
  pmid    = {31980586},
  url     = {https://doi.org/10.1523/jneurosci.1871-19.2019}
}

@article{weber2020-31959733,
  author  = {Weber, G. E. and Koenig, K. A. and Khrestian, M. and Shao, Y. and Tuason, E. D. and Gramm, M. and Lal, D. and Leverenz, J. B. and others},
  title   = {{An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2020},
  doi     = {10.4049/jimmunol.1901166},
  pmid    = {31959733},
  url     = {https://doi.org/10.4049/jimmunol.1901166}
}

@article{zhou2020-31932797,
  author  = {Zhou, Y. and Song, W. M. and Andhey, P. S. and Swain, A. and Levy, T. and Miller, K. R. and Poliani, P. L. and Cominelli, M. and others},
  title   = {{Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2020},
  doi     = {10.1038/s41591-019-0695-9},
  pmid    = {31932797},
  url     = {https://doi.org/10.1038/s41591-019-0695-9}
}

@article{nugent2020-31902528,
  author  = {Nugent, A. A. and Lin, K. and van Lengerich, B. and Lianoglou, S. and Przybyla, L. and Davis, S. S. and Llapashtica, C. and Wang, J. and others},
  title   = {{TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2019.12.007},
  pmid    = {31902528},
  url     = {https://doi.org/10.1016/j.neuron.2019.12.007}
}

@article{rauchmann2020-31958095,
  author  = {Rauchmann, B. S. and Sadlon, A. and Perneczky, R. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-191120},
  pmid    = {31958095},
  url     = {https://doi.org/10.3233/jad-191120}
}

@article{piers2020-31907987,
  author  = {Piers, T. M. and Cosker, K. and Mallach, A. and Johnson, G. T. and Guerreiro, R. and Hardy, J. and Pocock, J. M.},
  title   = {{A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2020},
  doi     = {10.1096/fj.201902447r},
  pmid    = {31907987},
  url     = {https://doi.org/10.1096/fj.201902447r}
}

@article{xue2020-31836271,
  author  = {Xue, D. and Tabib, T. and Morse, C. and Lafyatis, R.},
  title   = {{Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors}},
  journal = {Journal of dermatological science},
  year    = {2020},
  doi     = {10.1016/j.jdermsci.2019.11.012},
  pmid    = {31836271},
  url     = {https://doi.org/10.1016/j.jdermsci.2019.11.012}
}

@article{yao2019-31649511,
  author  = {Yao, H. and Coppola, K. and Schweig, J. E. and Crawford, F. and Mullan, M. and Paris, D.},
  title   = {{Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2019},
  doi     = {10.3389/fncel.2019.00457},
  pmid    = {31649511},
  url     = {https://doi.org/10.3389/fncel.2019.00457}
}

@article{liu2019-31477129,
  author  = {Liu, C. and Li, P. and Li, H. and Wang, S. and Ding, L. and Wang, H. and Ye, H. and Jin, Y. and others},
  title   = {{TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding}},
  journal = {Journal of translational medicine},
  year    = {2019},
  doi     = {10.1186/s12967-019-2050-9},
  pmid    = {31477129},
  url     = {https://doi.org/10.1186/s12967-019-2050-9}
}

@article{ewers2019-31462511,
  author  = {Ewers, M. and Franzmeier, N. and Suárez-Calvet, M. and Morenas-Rodriguez, E. and Caballero, M. A. A. and Kleinberger, G. and Piccio, L. and Cruchaga, C. and others},
  title   = {{Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease}},
  journal = {Science translational medicine},
  year    = {2019},
  doi     = {10.1126/scitranslmed.aav6221},
  pmid    = {31462511},
  url     = {https://doi.org/10.1126/scitranslmed.aav6221}
}

@article{deming2019-31413141,
  author  = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others},
  title   = {{The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk}},
  journal = {Science translational medicine},
  year    = {2019},
  doi     = {10.1126/scitranslmed.aau2291},
  pmid    = {31413141},
  url     = {https://doi.org/10.1126/scitranslmed.aau2291}
}

@article{guo2019-31370707,
  author  = {Guo, Y. and Wei, X. and Yan, H. and Qin, Y. and Yan, S. and Liu, J. and Zhao, Y. and Jiang, F. and others},
  title   = {{TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900992r},
  pmid    = {31370707},
  url     = {https://doi.org/10.1096/fj.201900992r}
}

@article{prokop2019-31350575,
  author  = {Prokop, S. and Miller, K. R. and Labra, SR. and Pitkin, R. M. and Hoxha, K. and Narasimhan, S. and Changolkar, L. and Rosenbloom, A. and others},
  title   = {{Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02048-2},
  pmid    = {31350575},
  url     = {https://doi.org/10.1007/s00401-019-02048-2}
}

@article{gervois2019-31379859,
  author  = {Gervois, P. and Lambrichts, I.},
  title   = {{The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke}},
  journal = {Frontiers in immunology},
  year    = {2019},
  doi     = {10.3389/fimmu.2019.01668},
  pmid    = {31379859},
  url     = {https://doi.org/10.3389/fimmu.2019.01668}
}

@article{griciuc2019-31301936,
  author  = {Griciuc, A. and Patel, S. and Federico, A. N. and Choi, S. H. and Innes, B. J. and Oram, M. K. and Cereghetti, G. and McGinty, D. and others},
  title   = {{TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2019},
  doi     = {10.1016/j.neuron.2019.06.010},
  pmid    = {31301936},
  url     = {https://doi.org/10.1016/j.neuron.2019.06.010}
}

@article{xu2019-31283973,
  author  = {Xu, Q. and Xu, W. and Cheng, H. and Yuan, H. and Tan, X.},
  title   = {{Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2}},
  journal = {Brain, behavior, and immunity},
  year    = {2019},
  doi     = {10.1016/j.bbi.2019.07.004},
  pmid    = {31283973},
  url     = {https://doi.org/10.1016/j.bbi.2019.07.004}
}

@article{jay2019-31265185,
  author  = {Jay, T. R. and von Saucken, V. E. and Muñoz, B. and Codocedo, J. F. and Atwood, B. K. and Lamb, B. T. and Landreth, G. E.},
  title   = {{TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23664},
  pmid    = {31265185},
  url     = {https://doi.org/10.1002/glia.23664}
}

@article{jaitin2019-31257031,
  author  = {Jaitin, D. A. and Adlung, L. and Thaiss, C. A. and Weiner, A. and Li, B. and Descamps, H. and Lundgren, P. and Bleriot, C. and others},
  title   = {{Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner}},
  journal = {Cell},
  year    = {2019},
  doi     = {10.1016/j.cell.2019.05.054},
  pmid    = {31257031},
  url     = {https://doi.org/10.1016/j.cell.2019.05.054}
}

@article{leyns2019-31235932,
  author  = {Leyns, C. E. G. and Gratuze, M. and Narasimhan, S. and Jain, N. and Koscal, L. J. and Jiang, H. and Manis, M. and Colonna, M. and others},
  title   = {{TREM2 function impedes tau seeding in neuritic plaques}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0433-0},
  pmid    = {31235932},
  url     = {https://doi.org/10.1038/s41593-019-0433-0}
}

@article{sheng2019-31219699,
  author  = {Sheng, L. and Chen, M. and Cai, K. and Song, Y. and Yu, D. and Zhang, H. and Xu, G.},
  title   = {{Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900527r},
  pmid    = {31219699},
  url     = {https://doi.org/10.1096/fj.201900527r}
}

@article{gotzl2019-31122931,
  author  = {Götzl, J. K. and Brendel, M. and Werner, G. and Parhizkar, S. and Sebastian Monasor, L. and Kleinberger, G. and Colombo, A. V. and Deussing, M. and others},
  title   = {{Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism}},
  journal = {EMBO molecular medicine},
  year    = {2019},
  doi     = {10.15252/emmm.201809711},
  pmid    = {31122931},
  url     = {https://doi.org/10.15252/emmm.201809711}
}

@article{long2019-31134514,
  author  = {Long, H. and Zhong, G. and Wang, C. and Zhang, J. and Zhang, Y. and Luo, J. and Shi, S.},
  title   = {{TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling}},
  journal = {Neurochemical research},
  year    = {2019},
  doi     = {10.1007/s11064-019-02817-1},
  pmid    = {31134514},
  url     = {https://doi.org/10.1007/s11064-019-02817-1}
}

@article{shirotani2019-31101881,
  author  = {Shirotani, K. and Hori, Y. and Yoshizaki, R. and Higuchi, E. and Colonna, M. and Saito, T. and Hashimoto, S. and others},
  title   = {{Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-43535-6},
  pmid    = {31101881},
  url     = {https://doi.org/10.1038/s41598-019-43535-6}
}

@article{delaguila2019-31068200,
  author  = {Del-Aguila, J. L. and Benitez, B. A. and Li, Z. and Dube, U. and Mihindukulasuriya, K. A. and Budde, J. P. and Farias, F. H. G. and Fernández, M. V. and others},
  title   = {{TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0319-3},
  pmid    = {31068200},
  url     = {https://doi.org/10.1186/s13024-019-0319-3}
}

@article{bozaserrano2019-31006066,
  author  = {Boza-Serrano, A. and Ruiz, R. and Sanchez-Varo, R. and García-Revilla, J. and Yang, Y. and Jimenez-Ferrer, I. and Paulus, A. and Wennström, M. and others},
  title   = {{Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02013-z},
  pmid    = {31006066},
  url     = {https://doi.org/10.1007/s00401-019-02013-z}
}

@article{wang2019-30930146,
  author  = {Wang, E. C. E. and Dai, Z. and Ferrante, A. W. and Drake, C. G. and Christiano, A. M.},
  title   = {{A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth}},
  journal = {Cell stem cell},
  year    = {2019},
  doi     = {10.1016/j.stem.2019.01.011},
  pmid    = {30930146},
  url     = {https://doi.org/10.1016/j.stem.2019.01.011}
}

@article{zhong2019-30911003,
  author  = {Zhong, L. and Xu, Y. and Zhuo, R. and Wang, T. and Wang, K. and Huang, R. and Wang, D. and Gao, Y. and others},
  title   = {{Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model}},
  journal = {Nature communications},
  year    = {2019},
  doi     = {10.1038/s41467-019-09118-9},
  pmid    = {30911003},
  url     = {https://doi.org/10.1038/s41467-019-09118-9}
}

@article{zhou2019-30756214,
  author  = {Zhou, J. and Yu, W. and Zhang, M. and Tian, X. and Li, Y. and Lü, Y.},
  title   = {{Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation}},
  journal = {Neurochemical research},
  year    = {2019},
  doi     = {10.1007/s11064-019-02748-x},
  pmid    = {30756214},
  url     = {https://doi.org/10.1007/s11064-019-02748-x}
}

@article{dalmasso2019-30705288,
  author  = {Dalmasso, M. C. and Brusco, L. I. and Olivar, N. and Muchnik, C. and Hanses, C. and Milz, E. and Becker, J. and Heilmann-Heimbach, S. and others},
  title   = {{Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease}},
  journal = {Translational psychiatry},
  year    = {2019},
  doi     = {10.1038/s41398-019-0394-9},
  pmid    = {30705288},
  url     = {https://doi.org/10.1038/s41398-019-0394-9}
}

@article{tang2019-30683932,
  author  = {Tang, W. and Lv, B. and Yang, B. and Chen, Y. and Yuan, F. and Ma, L. and Chen, S. and Zhang, S. and others},
  title   = {{TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway}},
  journal = {Oncogenesis},
  year    = {2019},
  doi     = {10.1038/s41389-018-0115-x},
  pmid    = {30683932},
  url     = {https://doi.org/10.1038/s41389-018-0115-x}
}

@article{liu2019-30684126,
  author  = {Liu, A. H. and Chu, M. and Wang, Y. P.},
  title   = {{Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice}},
  journal = {Neuroscience bulletin},
  year    = {2019},
  doi     = {10.1007/s12264-018-0324-5},
  pmid    = {30684126},
  url     = {https://doi.org/10.1007/s12264-018-0324-5}
}

@article{suarezcalvet2019-30630532,
  author  = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others},
  title   = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-018-0301-5},
  pmid    = {30630532},
  url     = {https://doi.org/10.1186/s13024-018-0301-5}
}

@article{parhizkar2019-30617257,
  author  = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others},
  title   = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-018-0296-9},
  pmid    = {30617257},
  url     = {https://doi.org/10.1038/s41593-018-0296-9}
}

@article{zhou2019-30883352,
  author  = {Zhou, S. L. and Tan, C. C. and Hou, X. H. and Cao, X. P. and Tan, L. and Yu, J. T.},
  title   = {{TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-181038},
  pmid    = {30883352},
  url     = {https://doi.org/10.3233/jad-181038}
}

@article{wolfe2018-30587772,
  author  = {Wolfe, C. M. and Fitz, N. F. and Nam, K. N. and Lefterov, I. and Koldamova, R.},
  title   = {{The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms20010081},
  pmid    = {30587772},
  url     = {https://doi.org/10.3390/ijms20010081}
}

@article{gratuze2018-30572908,
  author  = {Gratuze, M. and Leyns, C. E. G. and Holtzman, D. M.},
  title   = {{New insights into the role of TREM2 in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0298-9},
  pmid    = {30572908},
  url     = {https://doi.org/10.1186/s13024-018-0298-9}
}

@article{linnartzgerlach2019-30548312,
  author  = {Linnartz-Gerlach, B. and Bodea, L. G. and Klaus, C. and Ginolhac, A. and Halder, R. and Sinkkonen, L. and Walter, J. and Colonna, M. and others},
  title   = {{TREM2 triggers microglial density and age-related neuronal loss}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23563},
  pmid    = {30548312},
  url     = {https://doi.org/10.1002/glia.23563}
}

@article{shi2018-30140051,
  author  = {Shi, Y. and Holtzman, D. M.},
  title   = {{Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight}},
  journal = {Nature reviews. Immunology},
  year    = {2018},
  doi     = {10.1038/s41577-018-0051-1},
  pmid    = {30140051},
  url     = {https://doi.org/10.1038/s41577-018-0051-1}
}

@article{zheng2018-30532704,
  author  = {Zheng, H. and Cheng, B. and Li, Y. and Li, X. and Chen, X. and Zhang, Y. W.},
  title   = {{TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00395},
  pmid    = {30532704},
  url     = {https://doi.org/10.3389/fnagi.2018.00395}
}

@article{claes2019-30442540,
  author  = {Claes, C. and Van Den Daele, J. and Boon, R. and Schouteden, S. and Colombo, A. and Monasor, L. S. and Fiers, M. and Ordovás, L. and others},
  title   = {{Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2019},
  doi     = {10.1016/j.jalz.2018.09.006},
  pmid    = {30442540},
  url     = {https://doi.org/10.1016/j.jalz.2018.09.006}
}

@article{gisslen2019-30568991,
  author  = {Gisslén, M. and Heslegrave, A. and Veleva, E. and Yilmaz, A. and Andersson, L. M. and Hagberg, L. and Spudich, S. and Fuchs, D. and others},
  title   = {{CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection}},
  journal = {Neurology(R) neuroimmunology \& neuroinflammation},
  year    = {2019},
  doi     = {10.1212/nxi.0000000000000512},
  pmid    = {30568991},
  url     = {https://doi.org/10.1212/nxi.0000000000000512}
}

@article{lessard2018-30341064,
  author  = {Lessard, C. B. and Malnik, S. L. and Zhou, Y. and Ladd, T. B. and Cruz, P. E. and Ran, Y. and Mahan, T. E. and Chakrabaty, P. and others},
  title   = {{High-affinity interactions and signal transduction between Aβ oligomers and TREM2}},
  journal = {EMBO molecular medicine},
  year    = {2018},
  doi     = {10.15252/emmm.201809027},
  pmid    = {30341064},
  url     = {https://doi.org/10.15252/emmm.201809027}
}

@article{ulland2018-30266932,
  author  = {Ulland, T. K. and Colonna, M.},
  title   = {{TREM2 - a key player in microglial biology and Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2018},
  doi     = {10.1038/s41582-018-0072-1},
  pmid    = {30266932},
  url     = {https://doi.org/10.1038/s41582-018-0072-1}
}

@article{rauchmann2019-30458365,
  author  = {Rauchmann, B. S. and Schneider-Axmann, T. and Alexopoulos, P. and Perneczky, R. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum}},
  journal = {Neurobiology of aging},
  year    = {2019},
  doi     = {10.1016/j.neurobiolaging.2018.10.022},
  pmid    = {30458365},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2018.10.022}
}

@article{sayed2018-30232263,
  author  = {Sayed, F. A. and Telpoukhovskaia, M. and Kodama, L. and Li, Y. and Zhou, Y. and Le, D. and Hauduc, A. and Ludwig, C. and others},
  title   = {{Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2018},
  doi     = {10.1073/pnas.1811411115},
  pmid    = {30232263},
  url     = {https://doi.org/10.1073/pnas.1811411115}
}

@article{xiang2018-30185230,
  author  = {Xiang, X. and Piers, T. M. and Wefers, B. and Zhu, K. and Mallach, A. and Brunner, B. and Kleinberger, G. and Song, W. and others},
  title   = {{The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0280-6},
  pmid    = {30185230},
  url     = {https://doi.org/10.1186/s13024-018-0280-6}
}

@article{liu2018-30171911,
  author  = {Liu, D. and Cao, B. and Zhao, Y. and Huang, H. and McIntyre, R. S. and Rosenblat, J. D. and Zhou, H.},
  title   = {{Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis}},
  journal = {Neuroscience letters},
  year    = {2018},
  doi     = {10.1016/j.neulet.2018.08.038},
  pmid    = {30171911},
  url     = {https://doi.org/10.1016/j.neulet.2018.08.038}
}

@article{woollacott2018-30111356,
  author  = {Woollacott, I. O. C. and Nicholas, J. M. and Heslegrave, A. and Heller, C. and Foiani, M. S. and Dick, K. M. and Russell, L. L. and Paterson, R. W. and others},
  title   = {{Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0405-8},
  pmid    = {30111356},
  url     = {https://doi.org/10.1186/s13195-018-0405-8}
}

@article{konishi2018-30127720,
  author  = {Konishi, H. and Kiyama, H.},
  title   = {{Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2018},
  doi     = {10.3389/fncel.2018.00206},
  pmid    = {30127720},
  url     = {https://doi.org/10.3389/fncel.2018.00206}
}

@article{garciareitboeck2018-30157425,
  author  = {Garcia-Reitboeck, P. and Phillips, A. and Piers, T. M. and Villegas-Llerena, C. and Butler, M. and Mallach, A. and Rodrigues, C. and Arber, C. E. and others},
  title   = {{Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis}},
  journal = {Cell reports},
  year    = {2018},
  doi     = {10.1016/j.celrep.2018.07.094},
  pmid    = {30157425},
  url     = {https://doi.org/10.1016/j.celrep.2018.07.094}
}

@article{carmona2018-30033062,
  author  = {Carmona, S. and Zahs, K. and Wu, E. and Dakin, K. and Bras, J. and Guerreiro, R.},
  title   = {{The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders}},
  journal = {The Lancet. Neurology},
  year    = {2018},
  doi     = {10.1016/s1474-4422(18)30232-1},
  pmid    = {30033062},
  url     = {https://doi.org/10.1016/s1474-4422(18)30232-1}
}

@article{zhou2018-30038567,
  author  = {Zhou, Y. and Ulland, T. K. and Colonna, M.},
  title   = {{TREM2-Dependent Effects on Microglia in Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00202},
  pmid    = {30038567},
  url     = {https://doi.org/10.3389/fnagi.2018.00202}
}

@article{deming2018-3f7a9435,
  author  = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others},
  title   = {{The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk}},
  journal = {Science translational medicine},
  year    = {2018},
  doi     = {10.1101/352179},
  url     = {https://doi.org/10.1101/352179}
}

@article{chenghathaway2018-29859094,
  author  = {Cheng-Hathaway, P. J. and Reed-Geaghan, E. G. and Jay, T. R. and Casali, B. T. and Bemiller, S. M. and Puntambekar, S. S. and von Saucken, V. E. and Williams, R. Y. and others},
  title   = {{The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0262-8},
  pmid    = {29859094},
  url     = {https://doi.org/10.1186/s13024-018-0262-8}
}

@article{jiang2018-29362997,
  author  = {Jiang, T. and Zhang, Y. D. and Gao, Q. and Ou, Z. and Gong, P. Y. and Shi, J. Q. and Wu, L. and Zhou, J. S.},
  title   = {{TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response}},
  journal = {Inflammation},
  year    = {2018},
  doi     = {10.1007/s10753-018-0735-5},
  pmid    = {29362997},
  url     = {https://doi.org/10.1007/s10753-018-0735-5}
}

@article{sudom2018-29794134,
  author  = {Sudom, A. and Talreja, S. and Danao, J. and Bragg, E. and Kegel, R. and Min, X. and Richardson, J. and Zhang, Z. and others},
  title   = {{Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2}},
  journal = {The Journal of biological chemistry},
  year    = {2018},
  doi     = {10.1074/jbc.ra118.002352},
  pmid    = {29794134},
  url     = {https://doi.org/10.1074/jbc.ra118.002352}
}

@article{li2019-29663649,
  author  = {Li, C. and Zhao, B. and Lin, C. and Gong, Z. and An, X.},
  title   = {{TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling}},
  journal = {Cell biology international},
  year    = {2019},
  doi     = {10.1002/cbin.10975},
  pmid    = {29663649},
  url     = {https://doi.org/10.1002/cbin.10975}
}

@article{filipello2018-29752066,
  author  = {Filipello, F. and Morini, R. and Corradini, I. and Zerbi, V. and Canzi, A. and Michalski, B. and Erreni, M. and Markicevic, M. and others},
  title   = {{The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity}},
  journal = {Immunity},
  year    = {2018},
  doi     = {10.1016/j.immuni.2018.04.016},
  pmid    = {29752066},
  url     = {https://doi.org/10.1016/j.immuni.2018.04.016}
}

@article{li2018-29655369,
  author  = {Li, J. T. and Zhang, Y.},
  title   = {{TREM2 regulates innate immunity in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2018},
  doi     = {10.1186/s12974-018-1148-y},
  pmid    = {29655369},
  url     = {https://doi.org/10.1186/s12974-018-1148-y}
}

@article{zhang2018-29621548,
  author  = {Zhang, Y. and Feng, S. and Nie, K. and Li, Y. and Gao, Y. and Gan, R. and Wang, L. and Li, B. and others},
  title   = {{TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2018},
  doi     = {10.1016/j.bbrc.2018.03.226},
  pmid    = {29621548},
  url     = {https://doi.org/10.1016/j.bbrc.2018.03.226}
}

@article{brownjohn2018-29606617,
  author  = {Brownjohn, P. W. and Smith, J. and Solanki, R. and Lohmann, E. and Houlden, H. and Hardy, J. and Dietmann, S. and Livesey, F. J.},
  title   = {{Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia}},
  journal = {Stem cell reports},
  year    = {2018},
  doi     = {10.1016/j.stemcr.2018.03.003},
  pmid    = {29606617},
  url     = {https://doi.org/10.1016/j.stemcr.2018.03.003}
}

@article{cheng2018-29599291,
  author  = {Cheng, Q. and Danao, J. and Talreja, S. and Wen, P. and Yin, J. and Sun, N. and Li, C. M. and Chui, D. and others},
  title   = {{TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function}},
  journal = {The Journal of biological chemistry},
  year    = {2018},
  doi     = {10.1074/jbc.ra118.001848},
  pmid    = {29599291},
  url     = {https://doi.org/10.1074/jbc.ra118.001848}
}

@article{zhong2018-29587871,
  author  = {Zhong, L. and Wang, Z. and Wang, D. and Martens, Y. A. and Wu, L. and Xu, Y. and Wang, K. and others},
  title   = {{Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0247-7},
  pmid    = {29587871},
  url     = {https://doi.org/10.1186/s13024-018-0247-7}
}

@article{casati2018-29377401,
  author  = {Casati, M. and Ferri, E. and Gussago, C. and Mazzola, P. and Abbate, C. and Bellelli, G. and Mari, D. and Cesari, M. and others},
  title   = {{Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease}},
  journal = {European journal of neurology},
  year    = {2018},
  doi     = {10.1111/ene.13583},
  pmid    = {29377401},
  url     = {https://doi.org/10.1111/ene.13583}
}

@article{bekris2018-29685286,
  author  = {Bekris, L. M. and Khrestian, M. and Dyne, E. and Shao, Y. and Pillai, J. A. and Rao, S. M. and Bemiller, S. M. and Lamb, B. and others},
  title   = {{Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease}},
  journal = {Journal of neuroimmunology},
  year    = {2018},
  doi     = {10.1016/j.jneuroim.2018.03.003},
  pmid    = {29685286},
  url     = {https://doi.org/10.1016/j.jneuroim.2018.03.003}
}

@article{lee2018-29518357,
  author  = {Lee, C. Y. D. and Daggett, A. and Gu, X. and Jiang, L. L. and Langfelder, P. and Li, X. and Wang, N. and Zhao, Y. and others},
  title   = {{Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.02.002},
  pmid    = {29518357},
  url     = {https://doi.org/10.1016/j.neuron.2018.02.002}
}

@article{zhao2018-29518356,
  author  = {Zhao, Y. and Wu, X. and Li, X. and Jiang, L. L. and Gui, X. and Liu, Y. and Sun, Y. and Zhu, B. and others},
  title   = {{TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.01.031},
  pmid    = {29518356},
  url     = {https://doi.org/10.1016/j.neuron.2018.01.031}
}

@article{ren2018-29407460,
  author  = {Ren, M. and Guo, Y. and Wei, X. and Yan, S. and Qin, Y. and Zhang, X. and Jiang, F. and Lou, H.},
  title   = {{TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease}},
  journal = {Experimental neurology},
  year    = {2018},
  doi     = {10.1016/j.expneurol.2018.01.016},
  pmid    = {29407460},
  url     = {https://doi.org/10.1016/j.expneurol.2018.01.016}
}

@article{mecca2018-29361745,
  author  = {Mecca, C. and Giambanco, I. and Donato, R. and Arcuri, C.},
  title   = {{Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms19010318},
  pmid    = {29361745},
  url     = {https://doi.org/10.3390/ijms19010318}
}

@article{song2018-29321225,
  author  = {Song, W. M. and Joshita, S. and Zhou, Y. and Ulland, T. K. and Gilfillan, S. and Colonna, M.},
  title   = {{Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism}},
  journal = {The Journal of experimental medicine},
  year    = {2018},
  doi     = {10.1084/jem.20171529},
  pmid    = {29321225},
  url     = {https://doi.org/10.1084/jem.20171529}
}

@article{su2018-29322490,
  author  = {Su, W. H. and Shi, Z. H. and Liu, S. L. and Wang, X. D. and Liu, S. and Ji, Y.},
  title   = {{The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations}},
  journal = {Annals of human genetics},
  year    = {2018},
  doi     = {10.1111/ahg.12241},
  pmid    = {29322490},
  url     = {https://doi.org/10.1111/ahg.12241}
}

@article{kang2018-29040522,
  author  = {Kang, S. S. and Kurti, A. and Baker, K. E. and Liu, C. C. and Colonna, M. and Ulrich, J. D. and Holtzman, D. M. and Bu, G. and others},
  title   = {{Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal}},
  journal = {Human molecular genetics},
  year    = {2018},
  doi     = {10.1093/hmg/ddx366},
  pmid    = {29040522},
  url     = {https://doi.org/10.1093/hmg/ddx366}
}

@article{zhang2018-29104108,
  author  = {Zhang, X. and Wang, W. and Li, P. and Wang, X. and Ni, K.},
  title   = {{High TREM2 expression correlates with poor prognosis in gastric cancer}},
  journal = {Human pathology},
  year    = {2018},
  doi     = {10.1016/j.humpath.2017.10.026},
  pmid    = {29104108},
  url     = {https://doi.org/10.1016/j.humpath.2017.10.026}
}

@article{fahrenhold2018-28987033,
  author  = {Fahrenhold, M. and Rakic, S. and Classey, J. and Brayne, C. and Ince, P. G. and Nicoll, J. A. R. and Boche, D. and MRC-CFAS},
  title   = {{TREM2 expression in the human brain: a marker of monocyte recruitment?}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2018},
  doi     = {10.1111/bpa.12564},
  pmid    = {28987033},
  url     = {https://doi.org/10.1111/bpa.12564}
}

@article{bemiller2017-29037207,
  author  = {Bemiller, S. M. and McCray, T. J. and Allan, K. and Formica, S. V. and Xu, G. and Wilson, G. and Kokiko-Cochran, O. N. and Crish, S. D. and others},
  title   = {{TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0216-6},
  pmid    = {29037207},
  url     = {https://doi.org/10.1186/s13024-017-0216-6}
}

@article{hu2018-29051087,
  author  = {Hu, L. Y. and Zhou, Y. and Cui, W. Q. and Hu, X. M. and Du, L. X. and Mi, W. L. and Chu, Y. X. and Wu, G. C. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2018},
  doi     = {10.1016/j.bbi.2017.10.011},
  pmid    = {29051087},
  url     = {https://doi.org/10.1016/j.bbi.2017.10.011}
}

@article{condello2018-29169609,
  author  = {Condello, C. and Yuan, P. and Grutzendler, J.},
  title   = {{Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging}},
  journal = {Biological psychiatry},
  year    = {2018},
  doi     = {10.1016/j.biopsych.2017.10.007},
  pmid    = {29169609},
  url     = {https://doi.org/10.1016/j.biopsych.2017.10.007}
}

@article{leyns2017-29073081,
  author  = {Leyns, C. E. G. and Ulrich, J. D. and Finn, M. B. and Stewart, F. R. and Koscal, L. J. and Remolina Serrano, J. and Robinson, G. O. and Anderson, E. and others},
  title   = {{TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2017},
  doi     = {10.1073/pnas.1710311114},
  pmid    = {29073081},
  url     = {https://doi.org/10.1073/pnas.1710311114}
}

@article{schlepckow2017-28855300,
  author  = {Schlepckow, K. and Kleinberger, G. and Fukumori, A. and Feederle, R. and Lichtenthaler, S. F. and Steiner, H. and Haass, C.},
  title   = {{An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201707672},
  pmid    = {28855300},
  url     = {https://doi.org/10.15252/emmm.201707672}
}

@article{thornton2017-28855301,
  author  = {Thornton, P. and Sevalle, J. and Deery, M. J. and Fraser, G. and Zhou, Y. and Ståhl, S. and Franssen, E. H. and Dodd, R. B. and others},
  title   = {{TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201707673},
  pmid    = {28855301},
  url     = {https://doi.org/10.15252/emmm.201707673}
}

@article{feuerbach2017-28923481,
  author  = {Feuerbach, D. and Schindler, P. and Barske, C. and Joller, S. and Beng-Louka, E. and Worringer, K. A. and Kommineni, S. and Kaykas, A. and others},
  title   = {{ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157}},
  journal = {Neuroscience letters},
  year    = {2017},
  doi     = {10.1016/j.neulet.2017.09.034},
  pmid    = {28923481},
  url     = {https://doi.org/10.1016/j.neulet.2017.09.034}
}

@article{kim2017-28894284,
  author  = {Kim, S. M. and Mun, B. R. and Lee, S. J. and Joh, Y. and Lee, H. Y. and Ji, K. Y. and Choi, H. R. and Lee, E. H. and others},
  title   = {{TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-11634-x},
  pmid    = {28894284},
  url     = {https://doi.org/10.1038/s41598-017-11634-x}
}

@article{krasemann2017-28930663,
  author  = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others},
  title   = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}},
  journal = {Immunity},
  year    = {2017},
  doi     = {10.1016/j.immuni.2017.08.008},
  pmid    = {28930663},
  url     = {https://doi.org/10.1016/j.immuni.2017.08.008}
}

@article{jay2017-28768545,
  author  = {Jay, T. R. and von Saucken, V. E. and Landreth, G. E.},
  title   = {{TREM2 in Neurodegenerative Diseases}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0197-5},
  pmid    = {28768545},
  url     = {https://doi.org/10.1186/s13024-017-0197-5}
}

@article{ulland2017-28802038,
  author  = {Ulland, T. K. and Song, W. M. and Huang, S. C. and Ulrich, J. D. and Sergushichev, A. and Beatty, W. L. and Loboda, A. A. and Zhou, Y. and others},
  title   = {{TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease}},
  journal = {Cell},
  year    = {2017},
  doi     = {10.1016/j.cell.2017.07.023},
  pmid    = {28802038},
  url     = {https://doi.org/10.1016/j.cell.2017.07.023}
}

@article{sims2017-28714976,
  author  = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others},
  title   = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2017},
  doi     = {10.1038/ng.3916},
  pmid    = {28714976},
  url     = {https://doi.org/10.1038/ng.3916}
}

@article{zhong2017-28680398,
  author  = {Zhong, L. and Zhang, Z. L. and Li, X. and Liao, C. and Mou, P. and Wang, T. and Wang, Z. and others},
  title   = {{TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00204},
  pmid    = {28680398},
  url     = {https://doi.org/10.3389/fnagi.2017.00204}
}

@article{hauremirande2017-28612290,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Fanutza, T. and Kim, S. H. and Klein, W. L. and Glabe, C. and Readhead, B. and Dudley, J. T. and others},
  title   = {{Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology}},
  journal = {Acta neuropathologica},
  year    = {2017},
  doi     = {10.1007/s00401-017-1737-3},
  pmid    = {28612290},
  url     = {https://doi.org/10.1007/s00401-017-1737-3}
}

@article{wu2017-28592261,
  author  = {Wu, R. and Li, X. and Xu, P. and Huang, L. and Cheng, J. and Huang, X. and Jiang, J. and Wu, L. J. and others},
  title   = {{TREM2 protects against cerebral ischemia/reperfusion injury}},
  journal = {Molecular brain},
  year    = {2017},
  doi     = {10.1186/s13041-017-0296-9},
  pmid    = {28592261},
  url     = {https://doi.org/10.1186/s13041-017-0296-9}
}

@article{kleinberger2017-28559417,
  author  = {Kleinberger, G. and Brendel, M. and Mracsko, E. and Wefers, B. and Groeneweg, L. and Xiang, X. and Focke, C. and Deußing, M. and others},
  title   = {{The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism}},
  journal = {The EMBO journal},
  year    = {2017},
  doi     = {10.15252/embj.201796516},
  pmid    = {28559417},
  url     = {https://doi.org/10.15252/embj.201796516}
}

@article{castranio2017-28502803,
  author  = {Castranio, E. L. and Mounier, A. and Wolfe, C. M. and Nam, K. N. and Fitz, N. F. and Letronne, F. and Schug, J. and Koldamova, R. and others},
  title   = {{Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury}},
  journal = {Neurobiology of disease},
  year    = {2017},
  doi     = {10.1016/j.nbd.2017.05.006},
  pmid    = {28502803},
  url     = {https://doi.org/10.1016/j.nbd.2017.05.006}
}

@article{mazaheri2017-28483841,
  author  = {Mazaheri, F. and Snaidero, N. and Kleinberger, G. and Madore, C. and Daria, A. and Werner, G. and Krasemann, S. and Capell, A. and others},
  title   = {{TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury}},
  journal = {EMBO reports},
  year    = {2017},
  doi     = {10.15252/embr.201743922},
  pmid    = {28483841},
  url     = {https://doi.org/10.15252/embr.201743922}
}

@article{yeh2017-28442216,
  author  = {Yeh, F. L. and Hansen, D. V. and Sheng, M.},
  title   = {{TREM2, Microglia, and Neurodegenerative Diseases}},
  journal = {Trends in molecular medicine},
  year    = {2017},
  doi     = {10.1016/j.molmed.2017.03.008},
  pmid    = {28442216},
  url     = {https://doi.org/10.1016/j.molmed.2017.03.008}
}

@article{kober2017-28432014,
  author  = {Kober, D. L. and Brett, T. J.},
  title   = {{TREM2-Ligand Interactions in Health and Disease}},
  journal = {Journal of molecular biology},
  year    = {2017},
  doi     = {10.1016/j.jmb.2017.04.004},
  pmid    = {28432014},
  url     = {https://doi.org/10.1016/j.jmb.2017.04.004}
}

@article{ozaki2017-28412600,
  author  = {Ozaki, Y. and Yoshino, Y. and Yamazaki, K. and Sao, T. and Mori, Y. and Ochi, S. and Yoshida, T. and Mori, T. and others},
  title   = {{DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease}},
  journal = {Journal of psychiatric research},
  year    = {2017},
  doi     = {10.1016/j.jpsychires.2017.04.003},
  pmid    = {28412600},
  url     = {https://doi.org/10.1016/j.jpsychires.2017.04.003}
}

@article{ulrich2017-28426958,
  author  = {Ulrich, J. D. and Ulland, T. K. and Colonna, M. and Holtzman, D. M.},
  title   = {{Elucidating the Role of TREM2 in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.02.042},
  pmid    = {28426958},
  url     = {https://doi.org/10.1016/j.neuron.2017.02.042}
}

@article{jendresen2017-28320424,
  author  = {Jendresen, C. and Årskog, V. and Daws, M. R. and Nilsson, L. N.},
  title   = {{The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway}},
  journal = {Journal of neuroinflammation},
  year    = {2017},
  doi     = {10.1186/s12974-017-0835-4},
  pmid    = {28320424},
  url     = {https://doi.org/10.1186/s12974-017-0835-4}
}

@article{zhong2017-28209725,
  author  = {Zhong, L. and Chen, X. F. and Wang, T. and Wang, Z. and Liao, C. and Huang, R. and Wang, D. and others},
  title   = {{Soluble TREM2 induces inflammatory responses and enhances microglial survival}},
  journal = {The Journal of experimental medicine},
  year    = {2017},
  doi     = {10.1084/jem.20160844},
  pmid    = {28209725},
  url     = {https://doi.org/10.1084/jem.20160844}
}

@article{brendel2017-28197095,
  author  = {Brendel, M. and Kleinberger, G. and Probst, F. and Jaworska, A. and Overhoff, F. and Blume, T. and Albert, N. L. and Carlsen, J. and others},
  title   = {{Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00008},
  pmid    = {28197095},
  url     = {https://doi.org/10.3389/fnagi.2017.00008}
}

@article{dardiotis2017-28214109,
  author  = {Dardiotis, E. and Siokas, V. and Pantazi, E. and Dardioti, M. and Rikos, D. and Xiromerisiou, G. and Markou, A. and Papadimitriou, D. and others},
  title   = {{A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.01.015},
  pmid    = {28214109},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.01.015}
}

@article{zheng2017-28077724,
  author  = {Zheng, H. and Jia, L. and Liu, C. C. and Rong, Z. and Zhong, L. and Yang, L. and Chen, X. F. and Fryer, J. D. and others},
  title   = {{TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2459-16.2017},
  pmid    = {28077724},
  url     = {https://doi.org/10.1523/jneurosci.2459-16.2017}
}

@article{jay2017-28100745,
  author  = {Jay, T. R. and Hirsch, A. M. and Broihier, M. L. and Miller, C. M. and Neilson, L. E. and Ransohoff, R. M. and Lamb, B. T. and Landreth, G. E.},
  title   = {{Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2110-16.2016},
  pmid    = {28100745},
  url     = {https://doi.org/10.1523/jneurosci.2110-16.2016}
}

@article{raha2017-27662313,
  author  = {Raha, A. A. and Henderson, J. W. and Stott, SR. and Vuono, R. and Foscarin, S. and Friedland, R. P. and Zaman, S. H. and Raha-Chowdhury, R.},
  title   = {{Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160663},
  pmid    = {27662313},
  url     = {https://doi.org/10.3233/jad-160663}
}

@article{kober2016-27995897,
  author  = {Kober, D. L. and Alexander-Brett, J. M. and Karch, C. M. and Cruchaga, C. and Colonna, M. and Holtzman, M. J. and Brett, T. J.},
  title   = {{Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms}},
  journal = {eLife},
  year    = {2016},
  doi     = {10.7554/elife.20391},
  pmid    = {27995897},
  url     = {https://doi.org/10.7554/elife.20391}
}

@article{carrasquillo2017-27939925,
  author  = {Carrasquillo, M. M. and Allen, M. and Burgess, J. D. and Wang, X. and Strickland, S. L. and Aryal, S. and Siuda, J. and Kachadoorian, M. L. and others},
  title   = {{A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.10.005},
  pmid    = {27939925},
  url     = {https://doi.org/10.1016/j.jalz.2016.10.005}
}

@article{ma2016-27887626,
  author  = {Ma, L. and Allen, M. and Sakae, N. and Ertekin-Taner, N. and Graff-Radford, N. R. and Dickson, D. W. and Younkin, S. G. and Sevlever, D.},
  title   = {{Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0137-9},
  pmid    = {27887626},
  url     = {https://doi.org/10.1186/s13024-016-0137-9}
}

@article{yin2016-27717139,
  author  = {Yin, J. and Liu, X. and He, Q. and Zhou, L. and Yuan, Z. and Zhao, S.},
  title   = {{Vps35-dependent recycling of Trem2 regulates microglial function}},
  journal = {Traffic (Copenhagen, Denmark)},
  year    = {2016},
  doi     = {10.1111/tra.12451},
  pmid    = {27717139},
  url     = {https://doi.org/10.1111/tra.12451}
}

@article{kobayashi2016-27798193,
  author  = {Kobayashi, M. and Konishi, H. and Sayo, A. and Takai, T. and Kiyama, H.},
  title   = {{TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.1238-16.2016},
  pmid    = {27798193},
  url     = {https://doi.org/10.1523/jneurosci.1238-16.2016}
}

@article{sirkis2016-27589997,
  author  = {Sirkis, D. W. and Bonham, L. W. and Aparicio, R. E. and Geier, E. G. and Ramos, E. M. and Wang, Q. and Karydas, A. and Miller, Z. A. and others},
  title   = {{Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression}},
  journal = {Acta neuropathologica communications},
  year    = {2016},
  doi     = {10.1186/s40478-016-0367-7},
  pmid    = {27589997},
  url     = {https://doi.org/10.1186/s40478-016-0367-7}
}

@article{xiang2016-27402340,
  author  = {Xiang, X. and Werner, G. and Bohrmann, B. and Liesz, A. and Mazaheri, F. and Capell, A. and Feederle, R. and Knuesel, I. and others},
  title   = {{TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201606370},
  pmid    = {27402340},
  url     = {https://doi.org/10.15252/emmm.201606370}
}

@article{song2017-27520774,
  author  = {Song, W. and Hooli, B. and Mullin, K. and Jin, S. C. and Cella, M. and Ulland, T. K. and Wang, Y. and Tanzi, R. E. and others},
  title   = {{Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.07.004},
  pmid    = {27520774},
  url     = {https://doi.org/10.1016/j.jalz.2016.07.004}
}

@article{smith2016-27522519,
  author  = {Smith, A. R. and Smith, R. G. and Condliffe, D. and Hannon, E. and Schalkwyk, L. and Mill, J. and Lunnon, K.},
  title   = {{Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.07.008},
  pmid    = {27522519},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.07.008}
}

@article{gispert2016-27423963,
  author  = {Gispert, J. D. and Suárez-Calvet, M. and Monté, G. C. and Tucholka, A. and Falcon, C. and Rojas, S. and Rami, L. and Sánchez-Valle, R. and others},
  title   = {{Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.06.005},
  pmid    = {27423963},
  url     = {https://doi.org/10.1016/j.jalz.2016.06.005}
}

@article{yeh2016-27477018,
  author  = {Yeh, F. L. and Wang, Y. and Tom, I. and Gonzalez, L. C. and Sheng, M.},
  title   = {{TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia}},
  journal = {Neuron},
  year    = {2016},
  doi     = {10.1016/j.neuron.2016.06.015},
  pmid    = {27477018},
  url     = {https://doi.org/10.1016/j.neuron.2016.06.015}
}

@article{suarezcalvet2016-26941262,
  author  = {Suárez-Calvet, M. and Kleinberger, G. and MÁ, Araque Caballero and Brendel, M. and Rominger, A. and Alcolea, D. and Fortea, J. and Lleó, A. and others},
  title   = {{sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201506123},
  pmid    = {26941262},
  url     = {https://doi.org/10.15252/emmm.201506123}
}

@article{yuan2016-27196974,
  author  = {Yuan, P. and Condello, C. and Keene, C. D. and Wang, Y. and Bird, T. D. and Paul, S. M. and Luo, W. and Colonna, M. and others},
  title   = {{TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy}},
  journal = {Neuron},
  year    = {2016},
  doi     = {10.1016/j.neuron.2016.05.003},
  pmid    = {27196974},
  url     = {https://doi.org/10.1016/j.neuron.2016.05.003}
}

@article{henjum2016-27121148,
  author  = {Henjum, K. and Almdahl, I. S. and Årskog, V. and Minthon, L. and Hansson, O. and Fladby, T. and Nilsson, L. N.},
  title   = {{Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2016},
  doi     = {10.1186/s13195-016-0182-1},
  pmid    = {27121148},
  url     = {https://doi.org/10.1186/s13195-016-0182-1}
}

@article{wang2016-27091843,
  author  = {Wang, Y. and Ulland, T. K. and Ulrich, J. D. and Song, W. and Tzaferis, J. A. and Hole, J. T. and Yuan, P. and Mahan, T. E. and others},
  title   = {{TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques}},
  journal = {The Journal of experimental medicine},
  year    = {2016},
  doi     = {10.1084/jem.20151948},
  pmid    = {27091843},
  url     = {https://doi.org/10.1084/jem.20151948}
}

@article{celarain2016-27051467,
  author  = {Celarain, N. and Sánchez-Ruiz de Gordoa, J. and Zelaya, M. V. and Roldán, M. and Larumbe, R. and Pulido, L. and Echavarri, C. and Mendioroz, M.},
  title   = {{TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus}},
  journal = {Clinical epigenetics},
  year    = {2016},
  doi     = {10.1186/s13148-016-0202-9},
  pmid    = {27051467},
  url     = {https://doi.org/10.1186/s13148-016-0202-9}
}

@article{zheng2016-27143430,
  author  = {Zheng, H. and Liu, C. C. and Atagi, Y. and Chen, X. F. and Jia, L. and Yang, L. and He, W. and Zhang, X. and others},
  title   = {{Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.03.004},
  pmid    = {27143430},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.03.004}
}

@article{bhattacharjee2016-26949937,
  author  = {Bhattacharjee, S. and Zhao, Y. and Dua, P. and Rogaev, E. I. and Lukiw, W. J.},
  title   = {{microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration}},
  journal = {PloS one},
  year    = {2016},
  doi     = {10.1371/journal.pone.0150211},
  pmid    = {26949937},
  url     = {https://doi.org/10.1371/journal.pone.0150211}
}

@article{jiang2016-27067662,
  author  = {Jiang, T. and Tan, L. and Chen, Q. and Tan, M. S. and Zhou, J. S. and Zhu, X. C. and Lu, H. and Wang, H. F. and others},
  title   = {{A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.02.023},
  pmid    = {27067662},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.02.023}
}

@article{colonna2016-26911435,
  author  = {Colonna, M. and Wang, Y.},
  title   = {{TREM2 variants: new keys to decipher Alzheimer disease pathogenesis}},
  journal = {Nature reviews. Neuroscience},
  year    = {2016},
  doi     = {10.1038/nrn.2016.7},
  pmid    = {26911435},
  url     = {https://doi.org/10.1038/nrn.2016.7}
}

@article{ulrich2016-26854967,
  author  = {Ulrich, J. D. and Holtzman, D. M.},
  title   = {{TREM2 Function in Alzheimer's Disease and Neurodegeneration}},
  journal = {ACS chemical neuroscience},
  year    = {2016},
  doi     = {10.1021/acschemneuro.5b00313},
  pmid    = {26854967},
  url     = {https://doi.org/10.1021/acschemneuro.5b00313}
}

@article{jiang2016-26802771,
  author  = {Jiang, T. and Zhang, Y. D. and Chen, Q. and Gao, Q. and Zhu, X. C. and Zhou, J. S. and Shi, J. Q. and Lu, H. and others},
  title   = {{TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice}},
  journal = {Neuropharmacology},
  year    = {2016},
  doi     = {10.1016/j.neuropharm.2016.01.028},
  pmid    = {26802771},
  url     = {https://doi.org/10.1016/j.neuropharm.2016.01.028}
}

@article{heslegrave2016-26754172,
  author  = {Heslegrave, A. and Heywood, W. and Paterson, R. and Magdalinou, N. and Svensson, J. and Johansson, P. and Öhrfelt, A. and Blennow, K. and others},
  title   = {{Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0071-x},
  pmid    = {26754172},
  url     = {https://doi.org/10.1186/s13024-016-0071-x}
}

@article{piccio2016-26754641,
  author  = {Piccio, L. and Deming, Y. and Del-Águila, J. L. and Ghezzi, L. and Holtzman, D. M. and Fagan, A. M. and Fenoglio, C. and Galimberti, D. and others},
  title   = {{Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-016-1533-5},
  pmid    = {26754641},
  url     = {https://doi.org/10.1007/s00401-016-1533-5}
}

@article{ohrfelt2016-26754805,
  author  = {Öhrfelt, A. and Axelsson, M. and Malmeström, C. and Novakova, L. and Heslegrave, A. and Blennow, K. and Lycke, J. and Zetterberg, H.},
  title   = {{Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone}},
  journal = {Multiple sclerosis (Houndmills, Basingstoke, England)},
  year    = {2016},
  doi     = {10.1177/1352458515624558},
  pmid    = {26754805},
  url     = {https://doi.org/10.1177/1352458515624558}
}

@article{wang2016-26506595,
  author  = {Wang, X. Q. and Tao, B. B. and Li, B. and Wang, X. H. and Zhang, W. C. and Wan, L. and Hua, X. M. and Li, S. T.},
  title   = {{Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma}},
  journal = {Oncotarget},
  year    = {2016},
  doi     = {10.18632/oncotarget.6221},
  pmid    = {26506595},
  url     = {https://doi.org/10.18632/oncotarget.6221}
}

@article{jiang2016-27501831,
  author  = {Jiang, T. and Hou, J. K. and Gao, Q. and Yu, J. T. and Zhou, J. S. and Zhao, H. D. and Zhang, Y. D.},
  title   = {{TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects}},
  journal = {Current neurovascular research},
  year    = {2016},
  doi     = {10.2174/1567202613666160808095530},
  pmid    = {27501831},
  url     = {https://doi.org/10.2174/1567202613666160808095530}
}

@article{chan2015-26414614,
  author  = {Chan, G. and White, C. C. and Winn, P. A. and Cimpean, M. and Replogle, J. M. and Glick, L. R. and Cuerdon, N. E. and Ryan, K. J. and others},
  title   = {{CD33 modulates TREM2: convergence of Alzheimer loci}},
  journal = {Nature neuroscience},
  year    = {2015},
  doi     = {10.1038/nn.4126},
  pmid    = {26414614},
  url     = {https://doi.org/10.1038/nn.4126}
}

@article{atagi2015-26374899,
  author  = {Atagi, Y. and Liu, C. C. and Painter, M. M. and Chen, X. F. and Verbeeck, C. and Zheng, H. and Li, X. and Rademakers, R. and others},
  title   = {{Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.679043},
  pmid    = {26374899},
  url     = {https://doi.org/10.1074/jbc.m115.679043}
}

@article{liu2016-26365049,
  author  = {Liu, G. and Liu, Y. and Jiang, Q. and Jiang, Y. and Feng, R. and Zhang, L. and Chen, Z. and Li, K. and others},
  title   = {{Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility}},
  journal = {Molecular neurobiology},
  year    = {2016},
  doi     = {10.1007/s12035-015-9416-7},
  pmid    = {26365049},
  url     = {https://doi.org/10.1007/s12035-015-9416-7}
}

@article{painter2015-26337043,
  author  = {Painter, M. M. and Atagi, Y. and Liu, C. C. and Rademakers, R. and Xu, H. and Fryer, J. D. and Bu, G.},
  title   = {{TREM2 in CNS homeostasis and neurodegenerative disease}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0040-9},
  pmid    = {26337043},
  url     = {https://doi.org/10.1186/s13024-015-0040-9}
}

@article{huang2015-25852195,
  author  = {Huang, M. and Wang, D. and Xu, Z. and Xu, Y. and Xu, X. and Ma, Y. and Xia, Z.},
  title   = {{Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2015},
  doi     = {10.1177/1533317515577128},
  pmid    = {25852195},
  url     = {https://doi.org/10.1177/1533317515577128}
}

@article{jiang2015-26364736,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhou, J. S. and Cao, L. and Tan, M. S. and Wang, H. F. and Chen, Q. and others},
  title   = {{Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2015.08.019},
  pmid    = {26364736},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.08.019}
}

@article{korvatska2015-26076170,
  author  = {Korvatska, O. and Leverenz, J. B. and Jayadev, S. and McMillan, P. and Kurtz, I. and Guo, X. and Rumbaugh, M. and Matsushita, M. and others},
  title   = {{R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2015.0979},
  pmid    = {26076170},
  url     = {https://doi.org/10.1001/jamaneurol.2015.0979}
}

@article{lu2015-26037549,
  author  = {Lu, Y. and Liu, W. and Wang, X.},
  title   = {{TREM2 variants and risk of Alzheimer's disease: a meta-analysis}},
  journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
  year    = {2015},
  doi     = {10.1007/s10072-015-2274-2},
  pmid    = {26037549},
  url     = {https://doi.org/10.1007/s10072-015-2274-2}
}

@article{zhong2015-25957402,
  author  = {Zhong, L. and Chen, X. F. and Zhang, Z. L. and Wang, Z. and Shi, X. Z. and Xu, K. and Zhang, Y. W. and Xu, H. and others},
  title   = {{DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.645986},
  pmid    = {25957402},
  url     = {https://doi.org/10.1074/jbc.m115.645986}
}

@article{lill2015-25936935,
  author  = {Lill, C. M. and Rengmark, A. and Pihlstrøm, L. and Fogh, I. and Shatunov, A. and Sleiman, P. M. and Wang, L. S. and Liu, T. and others},
  title   = {{The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.12.009},
  pmid    = {25936935},
  url     = {https://doi.org/10.1016/j.jalz.2014.12.009}
}

@article{poliani2015-25893602,
  author  = {Poliani, P. L. and Wang, Y. and Fontana, E. and Robinette, M. L. and Yamanishi, Y. and Gilfillan, S. and Colonna, M.},
  title   = {{TREM2 sustains microglial expansion during aging and response to demyelination}},
  journal = {The Journal of clinical investigation},
  year    = {2015},
  doi     = {10.1172/jci77983},
  pmid    = {25893602},
  url     = {https://doi.org/10.1172/jci77983}
}

@article{jin2015-25886450,
  author  = {Jin, S. C. and Carrasquillo, M. M. and Benitez, B. A. and Skorupa, T. and Carrell, D. and Patel, D. and Lincoln, S. and Krishnan, S. and others},
  title   = {{TREM2 is associated with increased risk for Alzheimer's disease in African Americans}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0016-9},
  pmid    = {25886450},
  url     = {https://doi.org/10.1186/s13024-015-0016-9}
}

@article{savage2015-25904803,
  author  = {Savage, J. C. and Jay, T. and Goduni, E. and Quigley, C. and Mariani, M. M. and Malm, T. and Ransohoff, R. M. and Lamb, B. T. and others},
  title   = {{Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.4586-14.2015},
  pmid    = {25904803},
  url     = {https://doi.org/10.1523/jneurosci.4586-14.2015}
}

@article{xing2015-26478868,
  author  = {Xing, J. and Titus, A. R. and Humphrey, M. B.},
  title   = {{The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective}},
  journal = {Research and reports in biochemistry},
  year    = {2015},
  doi     = {10.2147/rrbc.s58057},
  pmid    = {26478868},
  url     = {https://doi.org/10.2147/rrbc.s58057}
}

@article{jay2015-25732305,
  author  = {Jay, T. R. and Miller, C. M. and Cheng, P. J. and Graham, L. C. and Bemiller, S. and Broihier, M. L. and Xu, G. and Margevicius, D. and others},
  title   = {{TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models}},
  journal = {The Journal of experimental medicine},
  year    = {2015},
  doi     = {10.1084/jem.20142322},
  pmid    = {25732305},
  url     = {https://doi.org/10.1084/jem.20142322}
}

@article{replogle2015-25545807,
  author  = {Replogle, J. M. and Chan, G. and White, C. C. and Raj, T. and Winn, P. A. and Evans, D. A. and Sperling, R. A. and Chibnik, L. B. and others},
  title   = {{A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24337},
  pmid    = {25545807},
  url     = {https://doi.org/10.1002/ana.24337}
}

@article{wang2015-25728668,
  author  = {Wang, Y. and Cella, M. and Mallinson, K. and Ulrich, J. D. and Young, K. L. and Robinette, M. L. and Gilfillan, S. and Krishnan, G. M. and others},
  title   = {{TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model}},
  journal = {Cell},
  year    = {2015},
  doi     = {10.1016/j.cell.2015.01.049},
  pmid    = {25728668},
  url     = {https://doi.org/10.1016/j.cell.2015.01.049}
}

@article{park2015-25615530,
  author  = {Park, J. S. and Ji, I. J. and An, H. J. and Kang, M. J. and Kang, S. W. and Kim, D. H. and Yoon, S. Y.},
  title   = {{Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus}},
  journal = {Traffic (Copenhagen, Denmark)},
  year    = {2015},
  doi     = {10.1111/tra.12264},
  pmid    = {25615530},
  url     = {https://doi.org/10.1111/tra.12264}
}

@article{kawabori2015-25716838,
  author  = {Kawabori, M. and Kacimi, R. and Kauppinen, T. and Calosing, C. and Kim, J. Y. and Hsieh, C. L. and Nakamura, M. C. and Yenari, M. A.},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.2620-14.2015},
  pmid    = {25716838},
  url     = {https://doi.org/10.1523/jneurosci.2620-14.2015}
}

@article{cantoni2015-25631124,
  author  = {Cantoni, C. and Bollman, B. and Licastro, D. and Xie, M. and Mikesell, R. and Schmidt, R. and Yuede, C. M. and Galimberti, D. and others},
  title   = {{TREM2 regulates microglial cell activation in response to demyelination in vivo}},
  journal = {Acta neuropathologica},
  year    = {2015},
  doi     = {10.1007/s00401-015-1388-1},
  pmid    = {25631124},
  url     = {https://doi.org/10.1007/s00401-015-1388-1}
}

@article{matarin2015-25620700,
  author  = {Matarin, M. and Salih, D. A. and Yasvoina, M. and Cummings, D. M. and Guelfi, S. and Liu, W. and Nahaboo Solim, M. A. and Moens, T. G. and others},
  title   = {{A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology}},
  journal = {Cell reports},
  year    = {2015},
  doi     = {10.1016/j.celrep.2014.12.041},
  pmid    = {25620700},
  url     = {https://doi.org/10.1016/j.celrep.2014.12.041}
}

@article{roussos2015-25499537,
  author  = {Roussos, P. and Katsel, P. and Fam, P. and Tan, W. and Purohit, D. P. and Haroutunian, V.},
  title   = {{The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.10.013},
  pmid    = {25499537},
  url     = {https://doi.org/10.1016/j.jalz.2014.10.013}
}

@article{lue2015-25186950,
  author  = {Lue, L. F. and Schmitz, C. T. and Serrano, G. and Sue, L. I. and Beach, T. G. and Walker, D. G.},
  title   = {{TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2015},
  doi     = {10.1111/bpa.12190},
  pmid    = {25186950},
  url     = {https://doi.org/10.1111/bpa.12190}
}

@article{lue2015-25281879,
  author  = {Lue, L. F. and Schmitz, C. and Walker, D. G.},
  title   = {{What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?}},
  journal = {Neuroscience},
  year    = {2015},
  doi     = {10.1016/j.neuroscience.2014.09.050},
  pmid    = {25281879},
  url     = {https://doi.org/10.1016/j.neuroscience.2014.09.050}
}

@article{hooli2014-25186855,
  author  = {Hooli, B. V. and Parrado, A. R. and Mullin, K. and Yip, W. K. and Liu, T. and Roehr, J. T. and Qiao, D. and Jessen, F. and others},
  title   = {{The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000855},
  pmid    = {25186855},
  url     = {https://doi.org/10.1212/wnl.0000000000000855}
}

@article{slattery2014-25160042,
  author  = {Slattery, C. F. and Beck, J. A. and Harper, L. and Adamson, G. and Abdi, Z. and Uphill, J. and Campbell, T. and Druyeh, R. and others},
  title   = {{R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2014},
  doi     = {10.1016/j.jalz.2014.05.1751},
  pmid    = {25160042},
  url     = {https://doi.org/10.1016/j.jalz.2014.05.1751}
}

@article{park2015-25114293,
  author  = {Park, M. and Yi, J. W. and Kim, E. M. and Yoon, I. J. and Lee, E. H. and Lee, H. Y. and Ji, K. Y. and Lee, K. H. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity}},
  journal = {Diabetes},
  year    = {2015},
  doi     = {10.2337/db13-1869},
  pmid    = {25114293},
  url     = {https://doi.org/10.2337/db13-1869}
}

@article{jiang2014-25047746,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhang, Q. Q. and Cao, L. and Tan, M. S. and Gu, L. Z. and Wang, H. F. and others},
  title   = {{Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2014},
  doi     = {10.1038/npp.2014.164},
  pmid    = {25047746},
  url     = {https://doi.org/10.1038/npp.2014.164}
}

@article{kleinberger2014-24990881,
  author  = {Kleinberger, G. and Yamanishi, Y. and Suárez-Calvet, M. and Czirr, E. and Lohmann, E. and Cuyvers, E. and Struyfs, H. and Pettkus, N. and others},
  title   = {{TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis}},
  journal = {Science translational medicine},
  year    = {2014},
  doi     = {10.1126/scitranslmed.3009093},
  pmid    = {24990881},
  url     = {https://doi.org/10.1126/scitranslmed.3009093}
}

@article{jin2014-24899047,
  author  = {Jin, S. C. and Benitez, B. A. and Karch, C. M. and Cooper, B. and Skorupa, T. and Carrell, D. and Norton, J. B. and Hsu, S. and others},
  title   = {{Coding variants in TREM2 increase risk for Alzheimer's disease}},
  journal = {Human molecular genetics},
  year    = {2014},
  doi     = {10.1093/hmg/ddu277},
  pmid    = {24899047},
  url     = {https://doi.org/10.1093/hmg/ddu277}
}

@article{ulrich2014-24893973,
  author  = {Ulrich, J. D. and Finn, M. B. and Wang, Y. and Shen, A. and Mahan, T. E. and Jiang, H. and Stewart, F. R. and Piccio, L. and others},
  title   = {{Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2014},
  doi     = {10.1186/1750-1326-9-20},
  pmid    = {24893973},
  url     = {https://doi.org/10.1186/1750-1326-9-20}
}

@article{jiao2014-24866402,
  author  = {Jiao, B. and Liu, X. and Tang, B. and Hou, L. and Zhou, L. and Zhang, F. and Zhou, Y. and Guo, J. and others},
  title   = {{Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.04.025},
  pmid    = {24866402},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.04.025}
}

@article{leber2014-24910390,
  author  = {Le Ber, I. and De Septenville, A. and Guerreiro, R. and Bras, J. and Camuzat, A. and Caroppo, P. and Lattante, S. and Couarch, P. and others},
  title   = {{Homozygous TREM2 mutation in a family with atypical frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.04.010},
  pmid    = {24910390},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.04.010}
}

@article{cady2014-24535663,
  author  = {Cady, J. and Koval, E. D. and Benitez, B. A. and Zaidman, C. and Jockel-Balsarotti, J. and Allred, P. and Baloh, R. H. and Ravits, J. and others},
  title   = {{TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.6237},
  pmid    = {24535663},
  url     = {https://doi.org/10.1001/jamaneurol.2013.6237}
}

@article{hu2014-24002183,
  author  = {Hu, N. and Tan, M. S. and Yu, J. T. and Sun, L. and Tan, L. and Wang, Y. L. and Jiang, T.},
  title   = {{Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-130854},
  pmid    = {24002183},
  url     = {https://doi.org/10.3233/jad-130854}
}

@article{miyashita2014-24762945,
  author  = {Miyashita, A. and Wen, Y. and Kitamura, N. and Matsubara, E. and Kawarabayashi, T. and Shoji, M. and Tomita, N. and Furukawa, K. and others},
  title   = {{Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-140225},
  pmid    = {24762945},
  url     = {https://doi.org/10.3233/jad-140225}
}

@article{benitez2014-24439484,
  author  = {Benitez, B. A. and Jin, S. C. and Guerreiro, R. and Graham, R. and Lord, J. and Harold, D. and Sims, R. and Lambert, J. C. and others},
  title   = {{Missense variant in TREML2 protects against Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.12.010},
  pmid    = {24439484},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.12.010}
}

@article{hickman2014-24355566,
  author  = {Hickman, S. E. and El Khoury, J.},
  title   = {{TREM2 and the neuroimmunology of Alzheimer's disease}},
  journal = {Biochemical pharmacology},
  year    = {2014},
  doi     = {10.1016/j.bcp.2013.11.021},
  pmid    = {24355566},
  url     = {https://doi.org/10.1016/j.bcp.2013.11.021}
}

@article{borroni2014-24139279,
  author  = {Borroni, B. and Ferrari, F. and Galimberti, D. and Nacmias, B. and Barone, C. and Bagnoli, S. and Fenoglio, C. and Piaceri, I. and others},
  title   = {{Heterozygous TREM2 mutations in frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.09.017},
  pmid    = {24139279},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.09.017}
}

@article{reitz2013-1f8a1527,
  author  = {Reitz, Christiane and Mayeux, Richard P},
  title   = {{TREM2 and Neurodegenerative Disease}},
  journal = {New England Journal of Medicine},
  year    = {2013},
  doi     = {10.1056/nejmc1306509},
  url     = {https://doi.org/10.1056/nejmc1306509}
}

@article{yu2014-24184202,
  author  = {Yu, J. T. and Jiang, T. and Wang, Y. L. and Wang, H. F. and Zhang, W. and Hu, N. and Tan, L. and Sun, L. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.10.075},
  pmid    = {24184202},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.10.075}
}

@article{cuyvers2014-24119542,
  author  = {Cuyvers, E. and Bettens, K. and Philtjens, S. and Van Langenhove, T. and Gijselinck, I. and van der Zee, J. and Engelborghs, S. and Vandenbulcke, M. and others},
  title   = {{Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.09.009},
  pmid    = {24119542},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.09.009}
}

@article{wunderlich2013-24078628,
  author  = {Wunderlich, P. and Glebov, K. and Kemmerling, N. and Tien, N. T. and Neumann, H. and Walter, J.},
  title   = {{Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m113.517540},
  pmid    = {24078628},
  url     = {https://doi.org/10.1074/jbc.m113.517540}
}

@article{ruiz2014-24041969,
  author  = {Ruiz, A. and Dols-Icardo, O. and Bullido, M. J. and Pastor, P. and Rodríguez-Rodríguez, E. and López de Munain, A. and de Pancorbo, M. M. and Pérez-Tur, J. and others},
  title   = {{Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.08.011},
  pmid    = {24041969},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.08.011}
}

@article{guerreiro2013-23870839,
  author  = {Guerreiro, R. and Bilgic, B. and Guven, G. and Brás, J. and Rohrer, J. and Lohmann, E. and Hanagasi, H. and Gurvit, H. and others},
  title   = {{Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.06.005},
  pmid    = {23870839},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.06.005}
}

@article{forabosco2013-23855984,
  author  = {Forabosco, P. and Ramasamy, A. and Trabzuni, D. and Walker, R. and Smith, C. and Bras, J. and Levine, A. P. and Hardy, J. and others},
  title   = {{Insights into TREM2 biology by network analysis of human brain gene expression data}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.05.001},
  pmid    = {23855984},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.05.001}
}

@article{rayaprolu2013-23800361,
  author  = {Rayaprolu, S. and Mullen, B. and Baker, M. and Lynch, T. and Finger, E. and Seeley, W. W. and Hatanpaa, K. J. and Lomen-Hoerth, C. and others},
  title   = {{TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2013},
  doi     = {10.1186/1750-1326-8-19},
  pmid    = {23800361},
  url     = {https://doi.org/10.1186/1750-1326-8-19}
}

@article{alexandrov2013-23778113,
  author  = {Alexandrov, P. N. and Zhao, Y. and Jones, B. M. and Bhattacharjee, S. and Lukiw, W. J.},
  title   = {{Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line}},
  journal = {Journal of inorganic biochemistry},
  year    = {2013},
  doi     = {10.1016/j.jinorgbio.2013.05.010},
  pmid    = {23778113},
  url     = {https://doi.org/10.1016/j.jinorgbio.2013.05.010}
}

@article{zhao2013-23462268,
  author  = {Zhao, Y. and Bhattacharjee, S. and Jones, B. M. and Dua, P. and Alexandrov, P. N. and Hill, J. M. and Lukiw, W. J.},
  title   = {{Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a}},
  journal = {Neuroreport},
  year    = {2013},
  doi     = {10.1097/wnr.0b013e32835fb6b0},
  pmid    = {23462268},
  url     = {https://doi.org/10.1097/wnr.0b013e32835fb6b0}
}

@article{jiang2013-23407992,
  author  = {Jiang, T. and Yu, J. T. and Zhu, X. C. and Tan, L.},
  title   = {{TREM2 in Alzheimer's disease}},
  journal = {Molecular neurobiology},
  year    = {2013},
  doi     = {10.1007/s12035-013-8424-8},
  pmid    = {23407992},
  url     = {https://doi.org/10.1007/s12035-013-8424-8}
}

@article{benitez2013-23391427,
  author  = {Benitez, B. A. and Cooper, B. and Pastor, P. and Jin, S. C. and Lorenzo, E. and Cervantes, S. and Cruchaga, C.},
  title   = {{TREM2 is associated with the risk of Alzheimer's disease in Spanish population}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2012.12.018},
  pmid    = {23391427},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2012.12.018}
}

@article{sieber2013-23301011,
  author  = {Sieber, M. W. and Jaenisch, N. and Brehm, M. and Guenther, M. and Linnartz-Gerlach, B. and Neumann, H. and Witte, O. W. and Frahm, C.},
  title   = {{Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0052982},
  pmid    = {23301011},
  url     = {https://doi.org/10.1371/journal.pone.0052982}
}

@article{pottier2013-23380991,
  author  = {Pottier, C. and Wallon, D. and Rousseau, S. and Rovelet-Lecrux, A. and Richard, A. C. and Rollin-Sillaire, A. and Frebourg, T. and Campion, D. and others},
  title   = {{TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-122311},
  pmid    = {23380991},
  url     = {https://doi.org/10.3233/jad-122311}
}

@article{guerreiro2013-23318515,
  author  = {Guerreiro, R. J. and Lohmann, E. and Brás, J. M. and Gibbs, JR. and Rohrer, J. D. and Gurunlian, N. and Dursun, B. and Bilgic, B. and others},
  title   = {{Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.579},
  pmid    = {23318515},
  url     = {https://doi.org/10.1001/jamaneurol.2013.579}
}

@article{guerreiro2013-23150934,
  author  = {Guerreiro, R. and Wojtas, A. and Bras, J. and Carrasquillo, M. and Rogaeva, E. and Majounie, E. and Cruchaga, C. and Sassi, C. and others},
  title   = {{TREM2 variants in Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2013},
  doi     = {10.1056/nejmoa1211851},
  pmid    = {23150934},
  url     = {https://doi.org/10.1056/nejmoa1211851}
}

@article{jonsson2013-23150908,
  author  = {Jonsson, T. and Stefansson, H. and Steinberg, S. and Jonsdottir, I. and Jonsson, P. V. and Snaedal, J. and Bjornsson, S. and Huttenlocher, J. and others},
  title   = {{Variant of TREM2 associated with the risk of Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2013},
  doi     = {10.1056/nejmoa1211103},
  pmid    = {23150908},
  url     = {https://doi.org/10.1056/nejmoa1211103}
}

@article{otero2012-22312126,
  author  = {Otero, K. and Shinohara, M. and Zhao, H. and Cella, M. and Gilfillan, S. and Colucci, A. and Faccio, R. and Ross, F. P. and others},
  title   = {{TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2012},
  doi     = {10.4049/jimmunol.1102836},
  pmid    = {22312126},
  url     = {https://doi.org/10.4049/jimmunol.1102836}
}

@article{ito2011-21956652,
  author  = {Ito, Hiroaki and Hamerman, Jessica A.},
  title   = {{TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells}},
  journal = {European Journal of Immunology},
  year    = {2011},
  doi     = {10.1002/eji.201141679},
  pmid    = {21956652},
  url     = {https://doi.org/10.1002/eji.201141679}
}

@article{numasawa2011-21834902,
  author  = {Numasawa, Y. and Yamaura, C. and Ishihara, S. and Shintani, S. and Yamazaki, M. and Tabunoki, H. and Satoh, J. I.},
  title   = {{Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family}},
  journal = {European journal of neurology},
  year    = {2011},
  doi     = {10.1111/j.1468-1331.2010.03311.x},
  pmid    = {21834902},
  url     = {https://doi.org/10.1111/j.1468-1331.2010.03311.x}
}

@article{melchior2010-20640189,
  author  = {Melchior, B. and Garcia, A. E. and Hsiung, B. K. and Lo, K. M. and Doose, J. M. and Thrash, J. C. and Stalder, A. K. and Staufenbiel, M. and others},
  title   = {{Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease}},
  journal = {ASN neuro},
  year    = {2010},
  doi     = {10.1042/an20100010},
  pmid    = {20640189},
  url     = {https://doi.org/10.1042/an20100010}
}

@article{peng2010-20484116,
  author  = {Peng, Q. and Malhotra, S. and Torchia, J. A. and Kerr, W. G. and Coggeshall, K. M. and Humphrey, M. B.},
  title   = {{TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1}},
  journal = {Science signaling},
  year    = {2010},
  doi     = {10.1126/scisignal.2000500},
  pmid    = {20484116},
  url     = {https://doi.org/10.1126/scisignal.2000500}
}

@article{stefano2009-19457124,
  author  = {Stefano, L. and Racchetti, G. and Bianco, F. and Passini, N. and Gupta, R. S. and Panina Bordignon, P. and Meldolesi, J.},
  title   = {{The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06130.x},
  pmid    = {19457124},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.06130.x}
}

@article{hsieh2009-19302484,
  author  = {Hsieh, C. L. and Koike, M. and Spusta, S. C. and Niemi, E. C. and Yenari, M. and Nakamura, M. C. and Seaman, W. E.},
  title   = {{A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06042.x},
  pmid    = {19302484},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.06042.x}
}

@article{ndiaye2009-19171755,
  author  = {N’Diaye, Elsa-Noah and Branda, Catherine and Branda, Steven S. and Nevarez, Lisette and Colonna, Marco and Lowell, Clifford A. and Hamerman, Jessica A. and Seaman, William E.},
  title   = {{TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria}},
  journal = {The Journal of Cell Biology},
  year    = {2009},
  doi     = {10.1083/jcb.200808080},
  pmid    = {19171755},
  url     = {https://doi.org/10.1083/jcb.200808080}
}

@article{seno2009-19109436,
  author  = {Seno, H. and Miyoshi, H. and Brown, S. L. and Geske, M. J. and Colonna, M. and Stappenbeck, T. S.},
  title   = {{Efficient colonic mucosal wound repair requires Trem2 signaling}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0803343106},
  pmid    = {19109436},
  url     = {https://doi.org/10.1073/pnas.0803343106}
}

@article{frank2008-18551625,
  author  = {Frank, S. and Burbach, G. J. and Bonin, M. and Walter, M. and Streit, W. and Bechmann, I. and Deller, T.},
  title   = {{TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice}},
  journal = {Glia},
  year    = {2008},
  doi     = {10.1002/glia.20710},
  pmid    = {18551625},
  url     = {https://doi.org/10.1002/glia.20710}
}

@article{piccio2008-18790823,
  author  = {Piccio, Laura M. and Buonsanti, Cecilia and Cella, Marina and Tassi, Ilaria and Schmidt, Robert E. and Fenoglio, Chiara and Rinker, John Robert and Naismith, Robert T. and Panina‐Bordignon, Paola and Passini, Nadia and Galimberti, Daniela and Scarpini, Elio Angelo and Colonna, Marco and Cross, Anne Haney},
  title   = {{Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation}},
  journal = {Brain},
  year    = {2008},
  doi     = {10.1093/brain/awn217},
  pmid    = {18790823},
  url     = {https://doi.org/10.1093/brain/awn217}
}

@article{chouery2008-18546367,
  author  = {Chouery, E. and Delague, V. and Bergougnoux, A. and Koussa, S. and Serre, J. L. and Mégarbané, A.},
  title   = {{Mutations in TREM2 lead to pure early-onset dementia without bone cysts}},
  journal = {Human mutation},
  year    = {2008},
  doi     = {10.1002/humu.20836},
  pmid    = {18546367},
  url     = {https://doi.org/10.1002/humu.20836}
}

@article{thrash2009-18404378,
  author  = {Thrash, J. C. and Torbett, B. E. and Carson, M. J.},
  title   = {{Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease}},
  journal = {Neurochemical research},
  year    = {2009},
  doi     = {10.1007/s11064-008-9657-1},
  pmid    = {18404378},
  url     = {https://doi.org/10.1007/s11064-008-9657-1}
}

@article{charles2008-18391000,
  author  = {Charles, J. F. and Humphrey, M. B. and Zhao, X. and Quarles, E. and Nakamura, M. C. and Aderem, A. and Seaman, W. E. and Smith, K. D.},
  title   = {{The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12}},
  journal = {Infection and immunity},
  year    = {2008},
  doi     = {10.1128/iai.00115-08},
  pmid    = {18391000},
  url     = {https://doi.org/10.1128/iai.00115-08}
}

@article{takahashi2007-17425404,
  author  = {Takahashi, K. and Prinz, M. and Stagi, M. and Chechneva, O. and Neumann, H.},
  title   = {{TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis}},
  journal = {PLoS medicine},
  year    = {2007},
  doi     = {10.1371/journal.pmed.0040124},
  pmid    = {17425404},
  url     = {https://doi.org/10.1371/journal.pmed.0040124}
}

@article{neumann2007-17239445,
  author  = {Neumann, H. and Takahashi, K.},
  title   = {{Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis}},
  journal = {Journal of neuroimmunology},
  year    = {2007},
  doi     = {10.1016/j.jneuroim.2006.11.032},
  pmid    = {17239445},
  url     = {https://doi.org/10.1016/j.jneuroim.2006.11.032}
}

@article{turnbull2006-16951310,
  author  = {Turnbull, Isaiah R. and Gilfillan, Susan and Cella, Marina and Aoshi, Taiki and Miller, Mark J. and Piccio, Laura M. and Hernandez, Maristela and Colonna, Marco},
  title   = {{Cutting Edge: TREM-2 Attenuates Macrophage Activation}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.6.3520},
  pmid    = {16951310},
  url     = {https://doi.org/10.4049/jimmunol.177.6.3520}
}

@article{hamerman2006-16887962,
  author  = {Hamerman, Jessica A. and Jarjoura, Jessica R and Humphrey, Mary Beth and Nakamura, Mary C. and Seaman, William E. and Lanier, Lewis L.},
  title   = {{Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.4.2051},
  pmid    = {16887962},
  url     = {https://doi.org/10.4049/jimmunol.177.4.2051}
}

@article{humphrey2006-16418779,
  author  = {Humphrey, M. B. and Daws, M. R. and Spusta, S. C. and Niemi, E. C. and Torchia, J. A. and Lanier, L. L. and Seaman, W. E. and Nakamura, M. C.},
  title   = {{TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function}},
  journal = {Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year    = {2006},
  doi     = {10.1359/jbmr.051016},
  pmid    = {16418779},
  url     = {https://doi.org/10.1359/jbmr.051016}
}

@article{kiialainen2005-15686960,
  author  = {Kiialainen, A. and Hovanes, K. and Paloneva, J. and Kopra, O. and Peltonen, L.},
  title   = {{Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2004.09.007},
  pmid    = {15686960},
  url     = {https://doi.org/10.1016/j.nbd.2004.09.007}
}

@article{sessa2004-15548205,
  author  = {Sessa, G. and Podini, P. and Mariani, M. and Meroni, A. and Spreafico, R. and Sinigaglia, F. and Colonna, M. and Panina, P. and others},
  title   = {{Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia}},
  journal = {The European journal of neuroscience},
  year    = {2004},
  doi     = {10.1111/j.1460-9568.2004.03729.x},
  pmid    = {15548205},
  url     = {https://doi.org/10.1111/j.1460-9568.2004.03729.x}
}

@article{paloneva2003-12925681,
  author  = {Paloneva, J. and Mandelin, J. and Kiialainen, A. and Bohling, T. and Prudlo, J. and Hakola, P. and Haltia, M. and Konttinen, Y. T. and others},
  title   = {{DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features}},
  journal = {The Journal of experimental medicine},
  year    = {2003},
  doi     = {10.1084/jem.20030027},
  pmid    = {12925681},
  url     = {https://doi.org/10.1084/jem.20030027}
}

@article{daws2003-12847223,
  author  = {Daws, Michael R. and Sullam, Paul M. and Niemi, Eréne C. and Chen, Thomas T. and Tchao, Nadia K. and Seaman, William E.},
  title   = {{Pattern Recognition by TREM-2: Binding of Anionic Ligands}},
  journal = {The Journal of Immunology},
  year    = {2003},
  doi     = {10.4049/jimmunol.171.2.594},
  pmid    = {12847223},
  url     = {https://doi.org/10.4049/jimmunol.171.2.594}
}

@article{colonna2003-12776204,
  author  = {Colonna, M.},
  title   = {{TREMs in the immune system and beyond}},
  journal = {Nature reviews. Immunology},
  year    = {2003},
  doi     = {10.1038/nri1106},
  pmid    = {12776204},
  url     = {https://doi.org/10.1038/nri1106}
}

@article{allcock2003-12645956,
  author  = {Allcock, R. J. and Barrow, A. D. and Forbes, S. and Beck, S. and Trowsdale, J.},
  title   = {{The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44}},
  journal = {European journal of immunology},
  year    = {2003},
  doi     = {10.1002/immu.200310033},
  pmid    = {12645956},
  url     = {https://doi.org/10.1002/immu.200310033}
}

@article{schmid2002-12472885,
  author  = {Schmid, Christoph D. and Sautkulis, Lauren N. and Danielson, Patria E. and Cooper, Judith and Hasel, Karl W. and Hilbush, Brian S. and Sutcliffe, J. Gregor and Carson, Monica J.},
  title   = {{Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia}},
  journal = {Journal of Neurochemistry},
  year    = {2002},
  doi     = {10.1046/j.1471-4159.2002.01243.x},
  pmid    = {12472885},
  url     = {https://doi.org/10.1046/j.1471-4159.2002.01243.x}
}

@article{bouchon2000-10799849,
  author  = {Bouchon, Axel and Dietrich, Jes and Colonna, Marco},
  title   = {{Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes}},
  journal = {The Journal of Immunology},
  year    = {2000},
  doi     = {10.4049/jimmunol.164.10.4991},
  pmid    = {10799849},
  url     = {https://doi.org/10.4049/jimmunol.164.10.4991}
}