% alzhub.org topic: glucagon-like
% Source: https://alzhub.org/topic/glucagon-like
% 285 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{santerre2026-42962966,
  author  = {Santerre, Maryline and Shcherbik, Natalia and Sawaya, Bassel E},
  title   = {{The metabolic-brain axis: GLP-1 signaling, insulin resistance, and obesity pharmacotherapy in neurodegeneration}},
  journal = {Metabolism: clinical and experimental},
  year    = {2026},
  doi     = {10.1016/j.metabol.2026.156810},
  pmid    = {42962966},
  url     = {https://doi.org/10.1016/j.metabol.2026.156810}
}

@article{reiter2026-d34fac97,
  author  = {Reiter, R. J. and Sharma, R. and Simão, V. A. and LGdA, Chuffa and Carloni, S. and Gentile, C. and Balduini, W. and Manucha, W.},
  title   = {{Beyond Glycemic Control: The Pleiotropic Role of GLP-1RAs and Melatonin in Combating Neuroinflammation and Mitochondrial Dysfunction}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202610.2789.v1},
  url     = {https://doi.org/10.20944/preprints202610.2789.v1}
}

@article{pfabe2026-5da1af17,
  author  = {Pfabe, J. and Postic, S. and Miglinci, L. and Krnjic, A. and Ahmed, H. and Eisenberg, T. and Tadic, J. and Raval, K. and others},
  title   = {{PFKFB3 inhibition restores β-cell responsiveness to acetylcholine in a 3xTg-AD pancreatic tissue-slice model}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.30.755766},
  url     = {https://doi.org/10.64898/2026.09.30.755766}
}

@article{brooks2026-82f57b8f,
  author  = {Brooks, J. D. and Donahue, M. A. and ElHassan, A. and Tian, J. and Hernandez-Diaz, S. and Blacker, D. and Estiri, H. and Haas, J. S. and others},
  title   = {{Patterns of GLP-1 Receptor Agonist Initiation Compared With Other Glucose-Lowering and Anti-Obesity Therapies Among Older Adults}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.29.26364340},
  url     = {https://doi.org/10.64898/2026.09.29.26364340}
}

@article{wohlfeld2026-d54ff148,
  author  = {Wohlfeld, C. and Blas, A. and Woodruff, J. and Frick, M. and Maciejewska, N. and Patel, A. and Grillo, C. and Reagan, L. and others},
  title   = {{Semaglutide Activates the Orexin/Hypocretin and Basal Forebrain Cholinergic Systems and Increases Acetylcholine Levels in the Hippocampus of Young and Aged Rats}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.03.742612},
  url     = {https://doi.org/10.64898/2026.08.03.742612}
}

@article{silva2026-e092d390,
  author  = {Silva, L. L. and Valverde, M. E. S. and Silva, A. M. P. and Braz, L. D. G. and da Silva, K. K. and Aguiar, E. M. and Volta, V. D. and de Oliveira, C. and others},
  title   = {{GLP-1 Receptor Agonists vs SGLT2 Inhibitors for Alzheimer’s Disease Risk in Type 2 Diabetes: A Systematic Review and Meta-Analysis}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.22.26358702},
  url     = {https://doi.org/10.64898/2026.07.22.26358702}
}

@article{pauley2026-42558640,
  author  = {Pauley, Meghan E and Coughlan, Christina and Dong, Fran and Bucca, Brian and Tanner, Bailey and Chartier-Logan, Catherine and Shapiro, Allison L B and Snell-Bergeon, Janet K},
  title   = {{Type 1 diabetes is associated with higher plasma levels of biomarkers of neurodegeneration and neuroinflammation}},
  journal = {Frontiers in immunology},
  year    = {2026},
  doi     = {10.3389/fimmu.2026.1860993},
  pmid    = {42558640},
  url     = {https://doi.org/10.3389/fimmu.2026.1860993}
}

@article{sulter2026-7e0e4d07,
  author  = {Sulter, G. A.},
  title   = {{Reversibility and Access: A Two-Axis Framework for Glucagon-Like Peptide-1 Receptor Agonists Across the Neurological Spectrum, and a Falsifiable Analgesic Hypothesis for Chronic Migraine}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202607.1279.v1},
  url     = {https://doi.org/10.20944/preprints202607.1279.v1}
}

@article{du2026-42330959,
  author  = {Du, Yixuan and Sun, Chujun and Wu, Lingxi and Wu, Zhongyun and Tong, Yue and Tian, Hong and Mao, Yang and Shi, Xupeiyao and others},
  title   = {{Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effects}},
  journal = {Cell metabolism},
  year    = {2026},
  doi     = {10.1016/j.cmet.2026.05.014},
  pmid    = {42330959},
  url     = {https://doi.org/10.1016/j.cmet.2026.05.014}
}

@article{fallot2026-42133988,
  author  = {Fallot, Lucas B and Anderson, Carol A and Pinc, Johnathan R and Stevenson, Alisdair and Schleck, Mary Claire and Hawryschuk, Ethan and Li, Owen Z and Palchak, Julia C and others},
  title   = {{Glucagon-Like Peptide-1 Receptor Agonists Inhibit the Initiation of Toxic Amyloid-β42 Aggregation}},
  journal = {Journal of the American Chemical Society},
  year    = {2026},
  doi     = {10.1021/jacs.6c01289},
  pmid    = {42133988},
  url     = {https://doi.org/10.1021/jacs.6c01289}
}

@article{engstrom2026-41994910,
  author  = {Engström, Arvid and Svanström, Henrik and Hviid, Anders and Eliasson, Björn and Gudbjörnsdottir, Soffia and Wintzell, Viktor and Hveem, Kristian and Jonasson, Christian and others},
  title   = {{Use of Glucagon-Like Peptide-1 Receptor Agonists and Risk of Parkinson's Disease: Scandinavian Cohort Study}},
  journal = {Diabetes, obesity \& metabolism},
  year    = {2026},
  doi     = {10.1111/dom.70760},
  pmid    = {41994910},
  url     = {https://doi.org/10.1111/dom.70760}
}

@article{choudhury2026-41862354,
  author  = {Choudhury, Ishraq and Ward, John Headly and Mahesh, Sahana and Alam, Uazman and Azmi, Shazli and Anson, Matthew},
  title   = {{Effect of Glucagon-Like-Peptide-1 Receptor Agonists (GLP-1 RA) on Neuropsychiatric Outcomes: A Systematic Review and Meta-Analysis}},
  journal = {Clinical therapeutics},
  year    = {2026},
  doi     = {10.1016/j.clinthera.2026.02.010},
  pmid    = {41862354},
  url     = {https://doi.org/10.1016/j.clinthera.2026.02.010}
}

@article{matuszewski2026-fe439787,
  author  = {Matuszewski, W. and Wołos-Kłosowicz, K. and Włodarczyk, P. and Waśniewska, P. and Modzelewski, R. and Górny, J. M. and Szklarz, M. and Juranek, J.},
  title   = {{Beyond Glycemic Control: GLP-1RA–Based Therapies and Emerging Targets Beyond the Metabolic Axis}},
  journal = {Journal of clinical medicine},
  year    = {2026},
  doi     = {10.20944/preprints202602.0277.v1},
  url     = {https://doi.org/10.20944/preprints202602.0277.v1}
}

@article{khan2025-41388533,
  author  = {Khan, Ali R and Makhoul, Gennifer Wahbah and Raji, Mukaila A},
  title   = {{Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults}},
  journal = {Endocrine regulations},
  year    = {2025},
  doi     = {10.2478/enr-2025-0030},
  pmid    = {41388533},
  url     = {https://doi.org/10.2478/enr-2025-0030}
}

@article{kotecha2025-0839901b,
  author  = {Kotecha, P. and Lee, Y. A. and Presti, M. F. and Guo, Y. and Bian, J. and Guo, J.},
  title   = {{Glucagon-Like Peptide-1 Receptor Agonists and Risk of Parkinsonian Disorders in Patients with Obesity}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.64898/2025.11.24.25340763},
  url     = {https://doi.org/10.64898/2025.11.24.25340763}
}

@article{schechter2025-41204243,
  author  = {Schechter, Meir and Fishkin, Alisa and Mosenzon, Ofri and Sehtman-Shachar, Dvora R and Cukierman-Yaffe, Tali and Leibowitz, Gil and Aharon-Hananel, Genya},
  title   = {{Neurodegeneration onset with glucagon-like peptide-1 receptor agonists in people with type 2 diabetes: a real-world multinational cohort study}},
  journal = {Cardiovascular diabetology},
  year    = {2025},
  doi     = {10.1186/s12933-025-02962-8},
  pmid    = {41204243},
  url     = {https://doi.org/10.1186/s12933-025-02962-8}
}

@article{moaket2025-41226780,
  author  = {Moaket, Osama Sobhi and Obaid, Sarah Eyad and Obaid, Fawaz Eyad and Shakeeb, Yusuf Abdulkarim and Elsharief, Samir Mohammed and Tania, Afrin and Darwish, Radwan and Butler, Alexandra E and others},
  title   = {{GLP-1 and the Degenerating Brain: Exploring Mechanistic Insights and Therapeutic Potential}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms262110743},
  pmid    = {41226780},
  url     = {https://doi.org/10.3390/ijms262110743}
}

@article{kim2025-41025359,
  author  = {Kim, JinWoo},
  title   = {{Glucagon-like peptide-1 receptor agonists and mental health: a narrative review of emerging benefits and risks}},
  journal = {Journal of Yeungnam medical science},
  year    = {2025},
  doi     = {10.12701/jyms.2025.42.61},
  pmid    = {41025359},
  url     = {https://doi.org/10.12701/jyms.2025.42.61}
}

@article{ibrahim2025-40964464,
  author  = {Ibrahim, Ruba and Kambal, Aya and Abdelmajeed, Mohammed A},
  title   = {{Glucagon-Like Peptide-1 Receptor Agonists in Neurodegenerative Diseases: A Comprehensive Review}},
  journal = {Cureus},
  year    = {2025},
  doi     = {10.7759/cureus.92441},
  pmid    = {40964464},
  url     = {https://doi.org/10.7759/cureus.92441}
}

@article{holscher2025-40938528,
  author  = {Hölscher, Christian},
  title   = {{Incretin Hormones GLP-1 and GIP Normalize Energy Utilization and Reduce Inflammation in the Brain in Alzheimer's Disease and Parkinson's Disease: From Repurposed GLP-1 Receptor Agonists to Novel Dual GLP-1/GIP Receptor Agonists as Potential Disease-Modifying Therapies}},
  journal = {CNS drugs},
  year    = {2025},
  doi     = {10.1007/s40263-025-01226-z},
  pmid    = {40938528},
  url     = {https://doi.org/10.1007/s40263-025-01226-z}
}

@article{zhang2025-40898408,
  author  = {Zhang, Pengyue and Mao, Chengsheng and Sun, Anna and Yang, Yuedi and Hou, Yuan and Fu, Zhimin and Babak, Tousi and Leverenz, James B and others},
  title   = {{Real-world observations of GLP-1 receptor agonists and SGLT-2 inhibitors as potential treatments for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70639},
  pmid    = {40898408},
  url     = {https://doi.org/10.1002/alz.70639}
}

@article{roy2025-40738791,
  author  = {Roy, Akash and Dawson, Valina L and Dawson, Ted M},
  title   = {{From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2025},
  doi     = {10.1016/j.neurot.2025.e00712},
  pmid    = {40738791},
  url     = {https://doi.org/10.1016/j.neurot.2025.e00712}
}

@article{alshehri2025-40498212,
  author  = {Alshehri, Ghadah H and Al-Kuraishy, Hayder M and Waheed, Huda Jaber and Al-Gareeb, Ali I and Faheem, Safaa A and Alexiou, Athanasios and Papadakis, Marios and Batiha, Gaber El-Saber},
  title   = {{Tirzepatide: a novel therapeutic approach for Alzheimer's disease}},
  journal = {Metabolic brain disease},
  year    = {2025},
  doi     = {10.1007/s11011-025-01649-z},
  pmid    = {40498212},
  url     = {https://doi.org/10.1007/s11011-025-01649-z}
}

@article{burns2025-40566796,
  author  = {Burns, Jeffrey M and Morris, Jill K and Vidoni, Eric D and Wilkins, Heather M and Choi, In-Young and Lee, Phil and Hunt, Suzanne L and Mahnken, Jonathan D and others},
  title   = {{Effects of the SGLT2 inhibitor dapagliflozin in early Alzheimer's disease: A randomized controlled trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70416},
  pmid    = {40566796},
  url     = {https://doi.org/10.1002/alz.70416}
}

@article{zhou2025-40344943,
  author  = {Zhou, Zhi Dong and Yi, Lingxiao and Popławska-Domaszewicz, Karolina and Chaudhuri, Kallol Ray and Jankovic, Joseph and Tan, Eng King},
  title   = {{Glucagon-like peptide-1 receptor agonists in neurodegenerative diseases: Promises and challenges}},
  journal = {Pharmacological research},
  year    = {2025},
  doi     = {10.1016/j.phrs.2025.107770},
  pmid    = {40344943},
  url     = {https://doi.org/10.1016/j.phrs.2025.107770}
}

@article{dzidickrivic2025-40272771,
  author  = {Džidić-Krivić, Amina and Fajkić, Almir and Farhat, Esma Karahmet and Lekić, Lana and Ejubović, Amira and Vukas, Samra Kadić and Ejubović, Malik and Lepara, Orhan and others},
  title   = {{Linking Metabolic Syndrome to Neurodegeneration Mechanisms and Potential Treatments}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-04947-w},
  pmid    = {40272771},
  url     = {https://doi.org/10.1007/s12035-025-04947-w}
}

@article{tseng2025-40189519,
  author  = {Tseng, Ping-Tao and Zeng, Bing-Yan and Hsu, Chih-Wei and Hung, Chao-Ming and Carvalho, Andre F and Stubbs, Brendon and Chen, Yen-Wen and Chen, Tien-Yu and others},
  title   = {{The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis}},
  journal = {BMC medicine},
  year    = {2025},
  doi     = {10.1186/s12916-025-04018-w},
  pmid    = {40189519},
  url     = {https://doi.org/10.1186/s12916-025-04018-w}
}

@article{west2025-40172827,
  author  = {West, Juliana and Li, Maggie and Wong, Sabrina and Le, Gia Han and Teopiz, Kayla M and Valentino, Kyle and Dri, Christine E and McIntyre, Roger S},
  title   = {{Are Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Central Nervous System (CNS) Penetrant: A Narrative Review}},
  journal = {Neurology and therapy},
  year    = {2025},
  doi     = {10.1007/s40120-025-00724-y},
  pmid    = {40172827},
  url     = {https://doi.org/10.1007/s40120-025-00724-y}
}

@article{sundararaman2025-40142784,
  author  = {Sundararaman, Lalitha and Gouda, Divakara and Kumar, Anil and Sundararaman, Sumithra and Goudra, Basavana},
  title   = {{Glucagon-like Peptide-1 Receptor Agonists: Exciting Avenues Beyond Weight Loss}},
  journal = {Journal of clinical medicine},
  year    = {2025},
  doi     = {10.3390/jcm14061978},
  pmid    = {40142784},
  url     = {https://doi.org/10.3390/jcm14061978}
}

@article{himmerich2025-40042613,
  author  = {Himmerich, Hubertus},
  title   = {{[Glucagon-like peptide-1 receptor agonists: a new pharmacological treatment option for psychiatric illnesses?]}},
  journal = {Der Nervenarzt},
  year    = {2025},
  doi     = {10.1007/s00115-025-01813-x},
  pmid    = {40042613},
  url     = {https://doi.org/10.1007/s00115-025-01813-x}
}

@article{sawamura2025-40001315,
  author  = {Sawamura, Toshitaka and Karashima, Shigehiro and Ohmori, Ai and Kometani, Mitsuhiro and Yoneda, Takashi},
  title   = {{Impacts of tirzepatide on older patients with diminished β-cell function and dementia}},
  journal = {Geriatrics \& gerontology international},
  year    = {2025},
  doi     = {10.1111/ggi.70018},
  pmid    = {40001315},
  url     = {https://doi.org/10.1111/ggi.70018}
}

@article{pillarisetti2025-39902055,
  author  = {Pillarisetti, Lekha and Agrawal, Devendra K},
  title   = {{Semaglutide: Double-edged Sword with Risks and Benefits}},
  journal = {Archives of internal medicine research},
  year    = {2025},
  doi     = {10.26502/aimr.0189},
  pmid    = {39902055},
  url     = {https://doi.org/10.26502/aimr.0189}
}

@article{yang2024-39716292,
  author  = {Yang, Yang and Shi, Guanjin and Ge, Yanyan and Huang, Shanshan and Cui, Ningning and Tan, Le and Liu, Rui and Yang, Xuefeng},
  title   = {{Accumulated BCAAs and BCKAs contribute to the HFD-induced deterioration of Alzheimer's disease via a dysfunctional TREM2-related reduction in microglial β-amyloid clearance}},
  journal = {Journal of neuroinflammation},
  year    = {2024},
  doi     = {10.1186/s12974-024-03314-1},
  pmid    = {39716292},
  url     = {https://doi.org/10.1186/s12974-024-03314-1}
}

@article{sasaki2024-39577079,
  author  = {Sasaki, Kana and Fujita, Hiroki and Sato, Takehiro and Kato, Shunske and Takahashi, Yuya and Takeshita, Yukio and Kanda, Takashi and Saito, Takashi and others},
  title   = {{GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2024},
  doi     = {10.1016/j.bbrc.2024.151016},
  pmid    = {39577079},
  url     = {https://doi.org/10.1016/j.bbrc.2024.151016}
}

@article{hong2024-39501255,
  author  = {Hong, C. T. and Chen, J. H. and Hu, C. J.},
  title   = {{Role of glucagon-like peptide-1 receptor agonists in Alzheimer's disease and Parkinson's disease}},
  journal = {Journal of biomedical science},
  year    = {2024},
  doi     = {10.1186/s12929-024-01090-x},
  pmid    = {39501255},
  url     = {https://doi.org/10.1186/s12929-024-01090-x}
}

@article{drucker2024-38843460,
  author  = {Drucker, D. J.},
  title   = {{Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity}},
  journal = {Diabetes care},
  year    = {2024},
  doi     = {10.2337/dci24-0003},
  pmid    = {38843460},
  url     = {https://doi.org/10.2337/dci24-0003}
}

@article{siddeeque2024-39486172,
  author  = {Siddeeque, N. and Hussein, M. H. and Abdelmaksoud, A. and Bishop, J. and Attia, A. S. and Elshazli, R. M. and Fawzy, M. S. and Toraih, E. A.},
  title   = {{Neuroprotective effects of GLP-1 receptor agonists in neurodegenerative Disorders: A Large-Scale Propensity-Matched cohort study}},
  journal = {International immunopharmacology},
  year    = {2024},
  doi     = {10.1016/j.intimp.2024.113537},
  pmid    = {39486172},
  url     = {https://doi.org/10.1016/j.intimp.2024.113537}
}

@article{taheri2024-39441380,
  author  = {Taheri, Mahdieh and Roghani, Mehrdad and Sedaghat, Reza},
  title   = {{Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Neurodegeneration}},
  journal = {Cellular and molecular neurobiology},
  year    = {2024},
  doi     = {10.1007/s10571-024-01502-4},
  pmid    = {39441380},
  url     = {https://doi.org/10.1007/s10571-024-01502-4}
}

@article{lv2024-39321702,
  author  = {Lv, Renjun and Zhao, Yan and Wang, Xiao and He, Yao and Dong, Na and Min, Xiangzhen and Liu, Xueying and Yu, Qin and others},
  title   = {{GLP-1 analogue liraglutide attenuates CIH-induced cognitive deficits by inhibiting oxidative stress, neuroinflammation, and apoptosis via the Nrf2/HO-1 and MAPK/NF-κB signaling pathways}},
  journal = {International immunopharmacology},
  year    = {2024},
  doi     = {10.1016/j.intimp.2024.113222},
  pmid    = {39321702},
  url     = {https://doi.org/10.1016/j.intimp.2024.113222}
}

@article{germano2024-39216535,
  author  = {Germano, Leticia Forny and Koehler, Jacqueline A and Baggio, Laurie L and Cui, Fiona and Wong, Chi Kin and Rittig, Nikolaj and Cao, Xiemin and Matthews, Dianne and others},
  title   = {{The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice}},
  journal = {Molecular metabolism},
  year    = {2024},
  doi     = {10.1016/j.molmet.2024.102019},
  pmid    = {39216535},
  url     = {https://doi.org/10.1016/j.molmet.2024.102019}
}

@article{depaiva2024-39042202,
  author  = {de Paiva, I. H. R. and da Silva, R. S. and Mendonça, I. P. and de Souza, J. R. B. and Peixoto, C. A.},
  title   = {{Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis}},
  journal = {Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology},
  year    = {2024},
  doi     = {10.1007/s11481-024-10142-w},
  pmid    = {39042202},
  url     = {https://doi.org/10.1007/s11481-024-10142-w}
}

@article{kopp2024-39062586,
  author  = {Kopp, Katherine O and Li, Yazhou and Glotfelty, Elliot J and Tweedie, David and Greig, Nigel H},
  title   = {{Incretin-Based Multi-Agonist Peptides Are Neuroprotective and Anti-Inflammatory in Cellular Models of Neurodegeneration}},
  journal = {Biomolecules},
  year    = {2024},
  doi     = {10.3390/biom14070872},
  pmid    = {39062586},
  url     = {https://doi.org/10.3390/biom14070872}
}

@article{abdalla2024-39099819,
  author  = {Abdalla, Mona Mohamed Ibrahim},
  title   = {{Insulin resistance as the molecular link between diabetes and Alzheimer's disease}},
  journal = {World journal of diabetes},
  year    = {2024},
  doi     = {10.4239/wjd.v15.i7.1430},
  pmid    = {39099819},
  url     = {https://doi.org/10.4239/wjd.v15.i7.1430}
}

@article{abdulrazeq2024-39959894,
  author  = {Abdulrazeq, Hael and Taman, Mazen and Ali, Rohaid and Doberstein, Cody and Sullivan, Patricia and Sampath, Prakash and Telfeian, Albert and Gokaslan, Ziya and others},
  title   = {{GLP-1 Receptor Agonists: Beyond Diabetes-What the Neurosurgeon Needs to Know}},
  journal = {Neurosurgery practice},
  year    = {2024},
  doi     = {10.1227/neuprac.0000000000000098},
  pmid    = {39959894},
  url     = {https://doi.org/10.1227/neuprac.0000000000000098}
}

@article{tang2024-39429814,
  author  = {Tang, Bowen and Sjölander, Arvid and Wastesson, Jonas W. and Maura, Géric and Blotière, Pierre‐Olivier and Szilcz, Máté and Mak, Jonathan K. L. and Qin, Chenxi and others},
  title   = {{Comparative effectiveness of glucagon-like peptide-1 agonists, dipeptidyl peptidase-4 inhibitors, and sulfonylureas on the risk of dementia in older individuals with type 2 diabetes in Sweden: an emulated trial study}},
  journal = {EClinicalMedicine},
  year    = {2024},
  doi     = {10.1016/j.eclinm.2024.102689},
  pmid    = {39429814},
  url     = {https://doi.org/10.1016/j.eclinm.2024.102689}
}

@article{zhao2024-38819697,
  author  = {Zhao, Wenyan and Zhang, Wei and Hu, Yingying and Zhou, Yuliang and Zhao, Jinying and Li, Yahong and Xu, Zhipeng},
  title   = {{AdipoRon Ameliorates Synaptic Dysfunction and Inhibits tau Hyperphosphorylation through the AdipoR/AMPK/mTOR Pathway in T2DM Mice}},
  journal = {Neurochemical research},
  year    = {2024},
  doi     = {10.1007/s11064-024-04162-4},
  pmid    = {38819697},
  url     = {https://doi.org/10.1007/s11064-024-04162-4}
}

@article{liang2024-38746639,
  author  = {Liang, Y. and Doré, V. and Rowe, C. C. and Krishnadas, N.},
  title   = {{Clinical Evidence for GLP-1 Receptor Agonists in Alzheimer's Disease: A Systematic Review}},
  journal = {Journal of Alzheimer's disease reports},
  year    = {2024},
  doi     = {10.3233/adr-230181},
  pmid    = {38746639},
  url     = {https://doi.org/10.3233/adr-230181}
}

@article{leibold2024-38663120,
  author  = {Leibold, Noah S and Despa, Florin},
  title   = {{Neuroinflammation induced by amyloid-forming pancreatic amylin: Rationale for a mechanistic hypothesis}},
  journal = {Biophysical chemistry},
  year    = {2024},
  doi     = {10.1016/j.bpc.2024.107252},
  pmid    = {38663120},
  url     = {https://doi.org/10.1016/j.bpc.2024.107252}
}

@article{fontanella2024-38287296,
  author  = {Fontanella, R. A. and Ghosh, P. and Pesapane, A. and Taktaz, F. and Puocci, A. and Franzese, M. and Feliciano, M. F. and Tortorella, G. and others},
  title   = {{Tirzepatide prevents neurodegeneration through multiple molecular pathways}},
  journal = {Journal of translational medicine},
  year    = {2024},
  doi     = {10.1186/s12967-024-04927-z},
  pmid    = {38287296},
  url     = {https://doi.org/10.1186/s12967-024-04927-z}
}

@article{cho2024-38238285,
  author  = {Cho, So Yeon and Kim, Eun Woo and Park, Soo Jin and Phillips, Benjamin U and Jeong, Jihyeon and Kim, Hyunjeong and Heath, Christopher J and Kim, Daehwan and others},
  title   = {{Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer's model mice}},
  journal = {Translational psychiatry},
  year    = {2024},
  doi     = {10.1038/s41398-024-02755-9},
  pmid    = {38238285},
  url     = {https://doi.org/10.1038/s41398-024-02755-9}
}

@article{akita2024-38185192,
  author  = {Akita, Tomomi and Shimamura, Mizuki and Tezuka, Ayano and Takagi, Marina and Yamashita, Chikamasa},
  title   = {{GLP-1 derivatives with functional sequences transit and migrate through trigeminal neurons}},
  journal = {European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year    = {2024},
  doi     = {10.1016/j.ejpb.2024.114176},
  pmid    = {38185192},
  url     = {https://doi.org/10.1016/j.ejpb.2024.114176}
}

@article{adem2024-38255204,
  author  = {Adem, Muna A and Decourt, Boris and Sabbagh, Marwan N},
  title   = {{Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer's Disease}},
  journal = {Biomedicines},
  year    = {2024},
  doi     = {10.3390/biomedicines12010099},
  pmid    = {38255204},
  url     = {https://doi.org/10.3390/biomedicines12010099}
}

@article{crook2024-39422964,
  author  = {Crook, Harry and Edison, Paul},
  title   = {{Incretin Mimetics as Potential Disease Modifying Treatment for Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-240730},
  pmid    = {39422964},
  url     = {https://doi.org/10.3233/jad-240730}
}

@article{erichsen2023-37786483,
  author  = {Erichsen, J. and Craft, S.},
  title   = {{Targeting immunometabolic pathways for combination therapy in Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2023},
  doi     = {10.1002/trc2.12423},
  pmid    = {37786483},
  url     = {https://doi.org/10.1002/trc2.12423}
}

@article{wang2023-37730113,
  author  = {Wang, Z. J. and Li, X. R. and Chai, S. F. and Li, W. R. and Li, S. and Hou, M. and Li, J. L. and Ye, Y. C. and others},
  title   = {{Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway}},
  journal = {Neuropharmacology},
  year    = {2023},
  doi     = {10.1016/j.neuropharm.2023.109716},
  pmid    = {37730113},
  url     = {https://doi.org/10.1016/j.neuropharm.2023.109716}
}

@article{ghosh2023-37771773,
  author  = {Ghosh, P. and Fontanella, R. A. and Scisciola, L. and Pesapane, A. and Taktaz, F. and Franzese, M. and Puocci, A. and Ceriello, A. and others},
  title   = {{Targeting redox imbalance in neurodegeneration: characterizing the role of GLP-1 receptor agonists}},
  journal = {Theranostics},
  year    = {2023},
  doi     = {10.7150/thno.86831},
  pmid    = {37771773},
  url     = {https://doi.org/10.7150/thno.86831}
}

@article{monney2023-37657738,
  author  = {Monney, M. and Jornayvaz, F. R. and Gariani, K.},
  title   = {{GLP-1 receptor agonists effect on cognitive function in patients with and without type 2 diabetes}},
  journal = {Diabetes \& metabolism},
  year    = {2023},
  doi     = {10.1016/j.diabet.2023.101470},
  pmid    = {37657738},
  url     = {https://doi.org/10.1016/j.diabet.2023.101470}
}

@article{goodarzi2023-37335453,
  author  = {Goodarzi, Golnaz and Tehrani, Sadra Samavarchi and Fana, Saeed Ebrahimi and Moradi-Sardareh, Hemen and Panahi, Ghodratollah and Maniati, Mahmood and Meshkani, Reza},
  title   = {{Crosstalk between Alzheimer's disease and diabetes: a focus on anti-diabetic drugs}},
  journal = {Metabolic brain disease},
  year    = {2023},
  doi     = {10.1007/s11011-023-01225-3},
  pmid    = {37335453},
  url     = {https://doi.org/10.1007/s11011-023-01225-3}
}

@article{nowell2023-37328112,
  author  = {Nowell, J. and Blunt, E. and Gupta, D. and Edison, P.},
  title   = {{Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2023.101979},
  pmid    = {37328112},
  url     = {https://doi.org/10.1016/j.arr.2023.101979}
}

@article{garciacasares2023-37231200,
  author  = {García-Casares, Natalia and González-González, Guillermo and de la Cruz-Cosme, Carlos and Garzón-Maldonado, Francisco J and de Rojas-Leal, Carmen and Ariza, María J and Narváez, Manuel and Barbancho, Miguel Ángel and others},
  title   = {{Effects of GLP-1 receptor agonists on neurological complications of diabetes}},
  journal = {Reviews in endocrine \& metabolic disorders},
  year    = {2023},
  doi     = {10.1007/s11154-023-09807-3},
  pmid    = {37231200},
  url     = {https://doi.org/10.1007/s11154-023-09807-3}
}

@article{alrouji2023-37173803,
  author  = {Alrouji, M. and Al-Kuraishy, H. M. and Al-Gareeb, A. I. and Alexiou, A. and Papadakis, M. and Saad, H. M. and Batiha, G. E.},
  title   = {{The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases}},
  journal = {Diabetology \& metabolic syndrome},
  year    = {2023},
  doi     = {10.1186/s13098-023-01082-1},
  pmid    = {37173803},
  url     = {https://doi.org/10.1186/s13098-023-01082-1}
}

@article{lee2023-36989942,
  author  = {Lee, Tae Suk and Park, Eun Ji and Choi, Minkyu and Oh, Hyun Seok and An, Yejin and Kim, Taehyung and Kim, Tae Hwan and Shin, Beom Soo and others},
  title   = {{Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies in rats}},
  journal = {Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year    = {2023},
  doi     = {10.1016/j.jchromb.2023.123688},
  pmid    = {36989942},
  url     = {https://doi.org/10.1016/j.jchromb.2023.123688}
}

@article{kreiner2023-37191234,
  author  = {Kreiner, Frederik Flindt and von Scholten, Bernt Johan and Kurtzhals, Peter and Gough, Stephen Charles Langford},
  title   = {{Glucagon-like peptide-1 receptor agonists to expand the healthy lifespan: Current and future potentials}},
  journal = {Aging cell},
  year    = {2023},
  doi     = {10.1111/acel.13818},
  pmid    = {37191234},
  url     = {https://doi.org/10.1111/acel.13818}
}

@article{alkuraishy2023-36849855,
  author  = {Al-Kuraishy, Hayder M and Al-Gareeb, Ali I and Saad, Hebatallah M and Batiha, Gaber El-Saber},
  title   = {{Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects}},
  journal = {Inflammopharmacology},
  year    = {2023},
  doi     = {10.1007/s10787-023-01163-7},
  pmid    = {36849855},
  url     = {https://doi.org/10.1007/s10787-023-01163-7}
}

@article{tang2023-36821780,
  author  = {Tang, H. and Shao, H. and Shaaban, C. E. and Yang, K. and Brown, J. and Anton, S. and Wu, Y. and Bress, A. and others},
  title   = {{Newer glucose-lowering drugs and risk of dementia: A systematic review and meta-analysis of observational studies}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2023},
  doi     = {10.1111/jgs.18306},
  pmid    = {36821780},
  url     = {https://doi.org/10.1111/jgs.18306}
}

@article{ezkurdia2023-36901787,
  author  = {Ezkurdia, Amaia and Ramírez, María J and Solas, Maite},
  title   = {{Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: A Focus on Insulin Resistance}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24054354},
  pmid    = {36901787},
  url     = {https://doi.org/10.3390/ijms24054354}
}

@article{viljoen2023-36740965,
  author  = {Viljoen, Adie and Bain, Stephen C},
  title   = {{Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond}},
  journal = {Endocrinology and metabolism (Seoul, Korea)},
  year    = {2023},
  doi     = {10.3803/enm.2022.1642},
  pmid    = {36740965},
  url     = {https://doi.org/10.3803/enm.2022.1642}
}

@article{holst2022-36629298,
  author  = {Holst, Jens Juul},
  title   = {{Incretin-based therapy of metabolic disease}},
  journal = {Danish medical journal},
  year    = {2022},
  pmid    = {36629298}
}

@article{chen2023-36470445,
  author  = {Chen, Shang-Der and Chuang, Yao-Chung and Lin, Tsu-Kung and Yang, Jenq-Lin},
  title   = {{Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases}},
  journal = {European journal of pharmacology},
  year    = {2023},
  doi     = {10.1016/j.ejphar.2022.175439},
  pmid    = {36470445},
  url     = {https://doi.org/10.1016/j.ejphar.2022.175439}
}

@article{du2022-36465634,
  author  = {Du, H. and Meng, X. and Yao, Y. and Xu, J.},
  title   = {{The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer's disease}},
  journal = {Frontiers in endocrinology},
  year    = {2022},
  doi     = {10.3389/fendo.2022.1033479},
  pmid    = {36465634},
  url     = {https://doi.org/10.3389/fendo.2022.1033479}
}

@article{kopp2022-36372278,
  author  = {Kopp, K. O. and Glotfelty, E. J. and Li, Y. and Greig, N. H.},
  title   = {{Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment}},
  journal = {Pharmacological research},
  year    = {2022},
  doi     = {10.1016/j.phrs.2022.106550},
  pmid    = {36372278},
  url     = {https://doi.org/10.1016/j.phrs.2022.106550}
}

@article{jangra2022-36505102,
  author  = {Jangra, Vani and Tople, Jeshnu},
  title   = {{Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus?}},
  journal = {Cureus},
  year    = {2022},
  doi     = {10.7759/cureus.31273},
  pmid    = {36505102},
  url     = {https://doi.org/10.7759/cureus.31273}
}

@article{vigil2022-36419765,
  author  = {Vigil, P. and Meléndez, J. and Petkovic, G. and Del Río, J. P.},
  title   = {{The importance of estradiol for body weight regulation in women}},
  journal = {Frontiers in endocrinology},
  year    = {2022},
  doi     = {10.3389/fendo.2022.951186},
  pmid    = {36419765},
  url     = {https://doi.org/10.3389/fendo.2022.951186}
}

@article{nowell2023-36258018,
  author  = {Nowell, J. and Blunt, E. and Edison, P.},
  title   = {{Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease}},
  journal = {Molecular psychiatry},
  year    = {2023},
  doi     = {10.1038/s41380-022-01792-4},
  pmid    = {36258018},
  url     = {https://doi.org/10.1038/s41380-022-01792-4}
}

@article{cater2022-36232867,
  author  = {Čater, Maša and Hölter, Sabine M},
  title   = {{A Pathophysiological Intersection of Diabetes and Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms231911562},
  pmid    = {36232867},
  url     = {https://doi.org/10.3390/ijms231911562}
}

@article{reich2022-36117625,
  author  = {Reich, N. and Hölscher, C.},
  title   = {{The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.970925},
  pmid    = {36117625},
  url     = {https://doi.org/10.3389/fnins.2022.970925}
}

@article{dizchaves2022-36076972,
  author  = {Diz-Chaves, Yolanda and Mastoor, Zainab and Spuch, Carlos and González-Matías, Lucas C and Mallo, Federico},
  title   = {{Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23179583},
  pmid    = {36076972},
  url     = {https://doi.org/10.3390/ijms23179583}
}

@article{qi2022-35985417,
  author  = {Qi, Liqin and Gao, Ruonan and Chen, Zhou and Lin, Donghai and Liu, Zhiqing and Wang, Linxi and Lin, Lijing and Liu, Xiaoying and others},
  title   = {{Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells}},
  journal = {Neurotoxicology},
  year    = {2022},
  doi     = {10.1016/j.neuro.2022.08.007},
  pmid    = {35985417},
  url     = {https://doi.org/10.1016/j.neuro.2022.08.007}
}

@article{monti2022-35805109,
  author  = {Monti, G. and Gomes Moreira, D. and Richner, M. and Mutsaers, H. A. M. and Ferreira, N. and Jan, A.},
  title   = {{GLP-1 Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11132023},
  pmid    = {35805109},
  url     = {https://doi.org/10.3390/cells11132023}
}

@article{mahapatra2022-35650449,
  author  = {Mahapatra, M. K. and Karuppasamy, M. and Sahoo, B. M.},
  title   = {{Therapeutic Potential of Semaglutide, a Newer GLP-1 Receptor Agonist, in Abating Obesity, Non-Alcoholic Steatohepatitis and Neurodegenerative diseases: A Narrative Review}},
  journal = {Pharmaceutical research},
  year    = {2022},
  doi     = {10.1007/s11095-022-03302-1},
  pmid    = {35650449},
  url     = {https://doi.org/10.1007/s11095-022-03302-1}
}

@article{cheng2022-35340338,
  author  = {Cheng, D. and Yang, S. and Zhao, X. and Wang, G.},
  title   = {{The Role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases}},
  journal = {Drug design, development and therapy},
  year    = {2022},
  doi     = {10.2147/dddt.s348055},
  pmid    = {35340338},
  url     = {https://doi.org/10.2147/dddt.s348055}
}

@article{cummings2022-35128745,
  author  = {Cummings, Jeffrey and Ortiz, Andrew and Castellino, Janelle and Kinney, Jefferson},
  title   = {{Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease}},
  journal = {The European journal of neuroscience},
  year    = {2022},
  doi     = {10.1111/ejn.15619},
  pmid    = {35128745},
  url     = {https://doi.org/10.1111/ejn.15619}
}

@article{norgaard2022-35229024,
  author  = {Nørgaard, C. H. and Friedrich, S. and Hansen, C. T. and Gerds, T. and Ballard, C. and Møller, D. V. and Knudsen, L. B. and Kvist, K. and others},
  title   = {{Treatment with glucagon-like peptide-1 receptor agonists and incidence of dementia: Data from pooled double-blind randomized controlled trials and nationwide disease and prescription registers}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12268},
  pmid    = {35229024},
  url     = {https://doi.org/10.1002/trc2.12268}
}

@article{mouhammad2022-35264926,
  author  = {Mouhammad, Zaynab Ahmad and Vohra, Rupali and Horwitz, Anna and Thein, Anna-Sophie and Rovelt, Jens and Cvenkel, Barbara and Williams, Pete A and Azuara-Blanco, Augusto and others},
  title   = {{Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.824054},
  pmid    = {35264926},
  url     = {https://doi.org/10.3389/fnins.2022.824054}
}

@article{khezri2022-35134385,
  author  = {Khezri, Mohammad Rafi and Yousefi, Keyvan and Mahboubi, Negin and Hodaei, Darya and Ghasemnejad-Berenji, Morteza},
  title   = {{Metformin in Alzheimer's disease: An overview of potential mechanisms, preclinical and clinical findings}},
  journal = {Biochemical pharmacology},
  year    = {2022},
  doi     = {10.1016/j.bcp.2022.114945},
  pmid    = {35134385},
  url     = {https://doi.org/10.1016/j.bcp.2022.114945}
}

@article{dizchaves2022-35180937,
  author  = {Diz-Chaves, Yolanda and Herrera-Pérez, Salvador and González-Matías, Lucas C and Mallo, Federico},
  title   = {{Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus}},
  journal = {Vitamins and hormones},
  year    = {2022},
  doi     = {10.1016/bs.vh.2021.12.005},
  pmid    = {35180937},
  url     = {https://doi.org/10.1016/bs.vh.2021.12.005}
}

@article{liao2021-35153733,
  author  = {Liao, Wang and Xu, Jiaxin and Li, Bo and Ruan, Yuting and Li, Tian and Liu, Jun},
  title   = {{Deciphering the Roles of Metformin in Alzheimer's Disease: A Snapshot}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.728315},
  pmid    = {35153733},
  url     = {https://doi.org/10.3389/fphar.2021.728315}
}

@article{laurindo2022-35054924,
  author  = {Laurindo, L. F. and Barbalho, S. M. and Guiguer, E. L. and da Silva Soares de Souza, M. and de Souza, G. A. and Fidalgo, T. M. and Araújo, A. C. and de Souza Gonzaga, H. F. and others},
  title   = {{GLP-1a: Going beyond Traditional Use}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23020739},
  pmid    = {35054924},
  url     = {https://doi.org/10.3390/ijms23020739}
}

@article{sanati2022-34999113,
  author  = {Sanati, Mehdi and Aminyavari, Samaneh and Afshari, Amir R and Sahebkar, Amirhossein},
  title   = {{Mechanistic insight into the role of metformin in Alzheimer's disease}},
  journal = {Life sciences},
  year    = {2022},
  doi     = {10.1016/j.lfs.2021.120299},
  pmid    = {34999113},
  url     = {https://doi.org/10.1016/j.lfs.2021.120299}
}

@article{carranzanaval2021-34975451,
  author  = {Carranza-Naval, María José and del Marco, Àngel and Hierro‐Bujalance, Carmen and Alves-Martínez, Pilar and Infante‐Garcia, Carmen and Vargas-Soria, María and Herrera, Marta and Barba-Cordoba, Belen and others},
  title   = {{Liraglutide Reduces Vascular Damage, Neuronal Loss, and Cognitive Impairment in a Mixed Murine Model of Alzheimer’s Disease and Type 2 Diabetes}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.741923},
  pmid    = {34975451},
  url     = {https://doi.org/10.3389/fnagi.2021.741923}
}

@article{deden2021-34942949,
  author  = {Deden, Laura N and Booij, Jan and Grandjean, Joanes and Homberg, Judith R and Hazebroek, Eric J and Gotthardt, Martin and Boss, Marti},
  title   = {{Brain Imaging of the GLP-1 Receptor in Obesity Using 68Ga-NODAGA-Exendin-4 PET}},
  journal = {Brain sciences},
  year    = {2021},
  doi     = {10.3390/brainsci11121647},
  pmid    = {34942949},
  url     = {https://doi.org/10.3390/brainsci11121647}
}

@article{zhang2022-34906628,
  author  = {Zhang, M. and Wu, Y. and Gao, R. and Chen, X. and Chen, R. and Chen, Z.},
  title   = {{Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimer's disease by suppressing NLRP2 activation in astrocytes}},
  journal = {Molecular and cellular endocrinology},
  year    = {2022},
  doi     = {10.1016/j.mce.2021.111529},
  pmid    = {34906628},
  url     = {https://doi.org/10.1016/j.mce.2021.111529}
}

@article{edison2021-157ef668,
  author  = {Edison, Paul and Femminella, Grazia Daniela and Ritchie, Craig William and Holmes, Clive and Walker, Zuzana and Ridha, Basil H. and Raza, Sanara and Livingston, Nicholas R and others},
  title   = {{Evaluation of liraglutide in the treatment of Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2021},
  doi     = {10.1002/alz.057848},
  url     = {https://doi.org/10.1002/alz.057848}
}

@article{liu2021-34676939,
  author  = {Liu, Xiao-Yu and Zhang, Ni and Zhang, Sheng-Xiao and Xu, Ping},
  title   = {{Potential new therapeutic target for Alzheimer's disease: Glucagon-like peptide-1}},
  journal = {The European journal of neuroscience},
  year    = {2021},
  doi     = {10.1111/ejn.15502},
  pmid    = {34676939},
  url     = {https://doi.org/10.1111/ejn.15502}
}

@article{li2021-34552561,
  author  = {Li, Qiu-Xuan and Gao, Han and Guo, Yue-Xin and Wang, Bo-Ya and Hua, Rong-Xuan and Gao, Lei and Shang, Hong-Wei and Lu, Xin and others},
  title   = {{GLP-1 and Underlying Beneficial Actions in Alzheimer's Disease, Hypertension, and NASH}},
  journal = {Frontiers in endocrinology},
  year    = {2021},
  doi     = {10.3389/fendo.2021.721198},
  pmid    = {34552561},
  url     = {https://doi.org/10.3389/fendo.2021.721198}
}

@article{begic2021-34479819,
  author  = {Begic, Edin and Causevic, Mirsada},
  title   = {{Glucagon-Like Peptide-1 Receptor Agonists and Brain Vascular Function}},
  journal = {Heart, lung \& circulation},
  year    = {2021},
  doi     = {10.1016/j.hlc.2021.07.024},
  pmid    = {34479819},
  url     = {https://doi.org/10.1016/j.hlc.2021.07.024}
}

@article{oliveira2021-34283253,
  author  = {Oliveira, Wilma Helena and Braga, Clarissa Figueiredo and Lós, Deniele Bezerra and Araújo, Shyrlene Meiry Rocha and França, MariaEduarda Rocha and Duarte-Silva, Eduardo and Rodrigues, Gabriel Barros and Rocha, Sura Wanessa Santos and others},
  title   = {{Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice}},
  journal = {Experimental brain research},
  year    = {2021},
  doi     = {10.1007/s00221-021-06176-8},
  pmid    = {34283253},
  url     = {https://doi.org/10.1007/s00221-021-06176-8}
}

@article{gomezapo2021-34327017,
  author  = {Gómez-Apo, Erick and Mondragón-Maya, Alejandra and Ferrari-Díaz, Martina and Silva-Pereyra, Juan},
  title   = {{Structural Brain Changes Associated with Overweight and Obesity}},
  journal = {Journal of obesity},
  year    = {2021},
  doi     = {10.1155/2021/6613385},
  pmid    = {34327017},
  url     = {https://doi.org/10.1155/2021/6613385}
}

@article{li2021-34250817,
  author  = {Li, Q. and Jia, M. and Yan, Z. and Sun, F. and He, C. and Li, Y. and Zhou, X. and others},
  title   = {{Activation of Glucagon-Like Peptide-1 Receptor Ameliorates Cognitive Decline in Type 2 Diabetes Mellitus Through a Metabolism-Independent Pathway}},
  journal = {Journal of the American Heart Association},
  year    = {2021},
  doi     = {10.1161/jaha.120.020734},
  pmid    = {34250817},
  url     = {https://doi.org/10.1161/jaha.120.020734}
}

@article{holscher2022-33900631,
  author  = {Hölscher, C.},
  title   = {{Protective properties of GLP-1 and associated peptide hormones in neurodegenerative disorders}},
  journal = {British journal of pharmacology},
  year    = {2022},
  doi     = {10.1111/bph.15508},
  pmid    = {33900631},
  url     = {https://doi.org/10.1111/bph.15508}
}

@article{zheng2021-33927970,
  author  = {Zheng, M. and Wang, P.},
  title   = {{Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease}},
  journal = {3 Biotech},
  year    = {2021},
  doi     = {10.1007/s13205-021-02738-3},
  pmid    = {33927970},
  url     = {https://doi.org/10.1007/s13205-021-02738-3}
}

@article{zheng2021-33556642,
  author  = {Zheng, J. and Xie, Y. and Ren, L. and Qi, L. and Wu, L. and Pan, X. and Zhou, J. and Chen, Z. and others},
  title   = {{GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease}},
  journal = {Molecular metabolism},
  year    = {2021},
  doi     = {10.1016/j.molmet.2021.101180},
  pmid    = {33556642},
  url     = {https://doi.org/10.1016/j.molmet.2021.101180}
}

@article{paladugu2021-33467075,
  author  = {Paladugu, L. and Gharaibeh, A. and Kolli, N. and Learman, C. and Hall, T. C. and Li, L. and Rossignol, J. and Maiti, P. and others},
  title   = {{RETRACTED: Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22020860},
  pmid    = {33467075},
  url     = {https://doi.org/10.3390/ijms22020860}
}

@article{yaribeygi2021-33121988,
  author  = {Yaribeygi, H. and Rashidy-Pour, A. and Atkin, S. L. and Jamialahmadi, T. and Sahebkar, A.},
  title   = {{GLP-1 mimetics and cognition}},
  journal = {Life sciences},
  year    = {2021},
  doi     = {10.1016/j.lfs.2020.118645},
  pmid    = {33121988},
  url     = {https://doi.org/10.1016/j.lfs.2020.118645}
}

@article{chang2020-33222922,
  author  = {Chang, Y. F. and Zhang, D. and Hu, W. M. and Liu, D. X. and Li, L.},
  title   = {{Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis}},
  journal = {Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year    = {2020},
  doi     = {10.1016/j.jocn.2020.09.054},
  pmid    = {33222922},
  url     = {https://doi.org/10.1016/j.jocn.2020.09.054}
}

@article{salameh2020-32755557,
  author  = {Salameh, T. S. and Rhea, E. M. and Talbot, K. and Banks, W. A.},
  title   = {{Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics}},
  journal = {Biochemical pharmacology},
  year    = {2020},
  doi     = {10.1016/j.bcp.2020.114187},
  pmid    = {32755557},
  url     = {https://doi.org/10.1016/j.bcp.2020.114187}
}

@article{kellar2020-32730766,
  author  = {Kellar, D. and Craft, S.},
  title   = {{Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches}},
  journal = {The Lancet. Neurology},
  year    = {2020},
  doi     = {10.1016/s1474-4422(20)30231-3},
  pmid    = {32730766},
  url     = {https://doi.org/10.1016/s1474-4422(20)30231-3}
}

@article{yu2020-32614526,
  author  = {Yu, Chun Jiang and Ma, Dongying and Song, Ling Ling and Zhai, Zhen Nan and Tao, Ye and Zhang, Ying and Cai, Ling Yu and Hou, Ya Hui and others},
  title   = {{The role of GLP-1/GIP receptor agonists in Alzheimer's disease}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2020},
  doi     = {10.17219/acem/121007},
  pmid    = {32614526},
  url     = {https://doi.org/10.17219/acem/121007}
}

@article{tomassoni2020-32397542,
  author  = {Tomassoni, Daniele and Martinelli, Ilenia and Moruzzi, Michele and Di Bonaventura, Maria Vittoria Micioni and Cifani, Carlo and Amenta, Francesco and Tayebati, Seyed Khosrow},
  title   = {{Obesity and Age-Related Changes in the Brain of the Zucker Lepr fa/fa Rats}},
  journal = {Nutrients},
  year    = {2020},
  doi     = {10.3390/nu12051356},
  pmid    = {32397542},
  url     = {https://doi.org/10.3390/nu12051356}
}

@article{tang2020-31751298,
  author  = {Tang, Bor Luen},
  title   = {{Could metformin be therapeutically useful in Huntington's disease?}},
  journal = {Reviews in the neurosciences},
  year    = {2020},
  doi     = {10.1515/revneuro-2019-0072},
  pmid    = {31751298},
  url     = {https://doi.org/10.1515/revneuro-2019-0072}
}

@article{reed2020-32269764,
  author  = {Reed, Josh and Bain, Stephen and Kanamarlapudi, Venkateswarlu},
  title   = {{Recent advances in understanding the role of glucagon-like peptide 1}},
  journal = {F1000Research},
  year    = {2020},
  doi     = {10.12688/f1000research.20602.1},
  pmid    = {32269764},
  url     = {https://doi.org/10.12688/f1000research.20602.1}
}

@article{holscher2020-32175781,
  author  = {Hölscher, C.},
  title   = {{Brain insulin resistance: role in neurodegenerative disease and potential for targeting}},
  journal = {Expert opinion on investigational drugs},
  year    = {2020},
  doi     = {10.1080/13543784.2020.1738383},
  pmid    = {32175781},
  url     = {https://doi.org/10.1080/13543784.2020.1738383}
}

@article{duarte2020-32143329,
  author  = {Duarte, A. I. and Candeias, E. and Alves, I. N. and Mena, D. and Silva, D. F. and Machado, N. J. and Campos, E. J. and Santos, M. S. and others},
  title   = {{Liraglutide Protects Against Brain Amyloid-β 1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21051746},
  pmid    = {32143329},
  url     = {https://doi.org/10.3390/ijms21051746}
}

@article{jantrapirom2020-32138327,
  author  = {Jantrapirom, Salinee and Nimlamool, Wutigri and Chattipakorn, Nipon and Chattipakorn, Siriporn Chaisin and Temviriyanukul, Piya and Inthachat, Woorawee and Govitrapong, Piyarat and Potikanond, Saranyapin},
  title   = {{Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity}},
  journal = {International Journal of Molecular Sciences},
  year    = {2020},
  doi     = {10.3390/ijms21051725},
  pmid    = {32138327},
  url     = {https://doi.org/10.3390/ijms21051725}
}

@article{mohamed2020-32000097,
  author  = {Mohamed, Marwan Abd Elbaset and Abdel-Rahman, Rehab F and Mahmoud, Sawsan S and Khattab, Mahmoud M and Safar, Marwa M},
  title   = {{Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats}},
  journal = {Epilepsy \& behavior : E\&B},
  year    = {2020},
  doi     = {10.1016/j.yebeh.2019.106893},
  pmid    = {32000097},
  url     = {https://doi.org/10.1016/j.yebeh.2019.106893}
}

@article{vadini2020-31965072,
  author  = {Vadini, F. and Simeone, P. G. and Boccatonda, A. and Guagnano, M. T. and Liani, R. and Tripaldi, R. and Di Castelnuovo, A. and Cipollone, F. and others},
  title   = {{Liraglutide improves memory in obese patients with prediabetes or early type 2 diabetes: a randomized, controlled study}},
  journal = {International journal of obesity (2005)},
  year    = {2020},
  doi     = {10.1038/s41366-020-0535-5},
  pmid    = {31965072},
  url     = {https://doi.org/10.1038/s41366-020-0535-5}
}

@article{cheng2020-31960630,
  author  = {Cheng, Li and Liu, Weizhen and Li, Xiaohui and Zhang, Zijuan and Qi, Huaxin and Liu, Shijin and Yan, Ningning and Xing, Ying and others},
  title   = {{The novel GLP‐1/GIP analogue DA5‐CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD}},
  journal = {Brain and Behavior},
  year    = {2020},
  doi     = {10.1002/brb3.1505},
  pmid    = {31960630},
  url     = {https://doi.org/10.1002/brb3.1505}
}

@article{akimoto2020-32162525,
  author  = {Akimoto, H. and Negishi, A. and Oshima, S. and Wakiyama, H. and Okita, M. and Horii, N. and Inoue, N. and Ohshima, S. and others},
  title   = {{Antidiabetic Drugs for the Risk of Alzheimer Disease in Patients With Type 2 DM Using FAERS}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2020},
  doi     = {10.1177/1533317519899546},
  pmid    = {32162525},
  url     = {https://doi.org/10.1177/1533317519899546}
}

@article{maskery2020-32959677,
  author  = {Maskery, M. and Goulding, E. M. and Gengler, S. and Melchiorsen, J. U. and Rosenkilde, M. M. and Hölscher, C.},
  title   = {{The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2020},
  doi     = {10.1177/1533317520953041},
  pmid    = {32959677},
  url     = {https://doi.org/10.1177/1533317520953041}
}

@article{sayed2020-31728850,
  author  = {Sayed, N. H. and Fathy, N. and Kortam, M. A. and Rabie, M. A. and Mohamed, A. F. and Kamel, A. S.},
  title   = {{Vildagliptin Attenuates Huntington's Disease through Activation of GLP-1 Receptor/PI3K/Akt/BDNF Pathway in 3-Nitropropionic Acid Rat Model}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2020},
  doi     = {10.1007/s13311-019-00805-5},
  pmid    = {31728850},
  url     = {https://doi.org/10.1007/s13311-019-00805-5}
}

@article{zhang2020-31705913,
  author  = {Zhang, Z. Q. and Hölscher, C.},
  title   = {{GIP has neuroprotective effects in Alzheimer and Parkinson's disease models}},
  journal = {Peptides},
  year    = {2020},
  doi     = {10.1016/j.peptides.2019.170184},
  pmid    = {31705913},
  url     = {https://doi.org/10.1016/j.peptides.2019.170184}
}

@article{boccardi2019-31330313,
  author  = {Boccardi, V. and Murasecco, I. and Mecocci, P.},
  title   = {{Diabetes drugs in the fight against Alzheimer's disease}},
  journal = {Ageing research reviews},
  year    = {2019},
  doi     = {10.1016/j.arr.2019.100936},
  pmid    = {31330313},
  url     = {https://doi.org/10.1016/j.arr.2019.100936}
}

@article{altuntas2019-32377065,
  author  = {Altuntaş, Yüksel},
  title   = {{Approach Toward Diabetes Treatment in the Elderly}},
  journal = {Sisli Etfal Hastanesi tip bulteni},
  year    = {2019},
  doi     = {10.14744/semb.2019.00868},
  pmid    = {32377065},
  url     = {https://doi.org/10.14744/semb.2019.00868}
}

@article{yan2019-31201846,
  author  = {Yan, W. and Pang, M. and Yu, Y. and Gou, X. and Si, P. and Zhawatibai, A. and Zhang, Y. and Zhang, M. and others},
  title   = {{The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis}},
  journal = {Life sciences},
  year    = {2019},
  doi     = {10.1016/j.lfs.2019.116566},
  pmid    = {31201846},
  url     = {https://doi.org/10.1016/j.lfs.2019.116566}
}

@article{chen2019-31199957,
  author  = {Chen, S. and Zhou, M. and Sun, J. and Guo, A. and Fernando, R. L. and Chen, Y. and Peng, P. and Zhao, G. and others},
  title   = {{DPP-4 inhibitor improves learning and memory deficits and AD-like neurodegeneration by modulating the GLP-1 signaling}},
  journal = {Neuropharmacology},
  year    = {2019},
  doi     = {10.1016/j.neuropharm.2019.107668},
  pmid    = {31199957},
  url     = {https://doi.org/10.1016/j.neuropharm.2019.107668}
}

@article{bazzari2019-31137621,
  author  = {Bazzari, F. H. and Abdallah, D. M. and El-Abhar, H. S.},
  title   = {{Chenodeoxycholic Acid Ameliorates AlCl 3 -Induced Alzheimer's Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2019},
  doi     = {10.3390/molecules24101992},
  pmid    = {31137621},
  url     = {https://doi.org/10.3390/molecules24101992}
}

@article{day2019-31040160,
  author  = {Day, Stephen M and Yang, Wenzhong and Wang, Xin and Stern, Jennifer E and Zhou, Xueyan and Macauley, Shannon L and Ma, Tao},
  title   = {{Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome}},
  journal = {eNeuro},
  year    = {2019},
  doi     = {10.1523/eneuro.0031-19.2019},
  pmid    = {31040160},
  url     = {https://doi.org/10.1523/eneuro.0031-19.2019}
}

@article{an2019-31082410,
  author  = {An, J. and Zhou, Y. and Zhang, M. and Xie, Y. and Ke, S. and Liu, L. and Pan, X. and Chen, Z.},
  title   = {{Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease}},
  journal = {Behavioural brain research},
  year    = {2019},
  doi     = {10.1016/j.bbr.2019.111932},
  pmid    = {31082410},
  url     = {https://doi.org/10.1016/j.bbr.2019.111932}
}

@article{mandarimdelacerda2019-31020988,
  author  = {Mandarim-de-Lacerda, Carlos A},
  title   = {{Pancreatic islet (of Langerhans) revisited}},
  journal = {Histology and histopathology},
  year    = {2019},
  doi     = {10.14670/hh-18-118},
  pmid    = {31020988},
  url     = {https://doi.org/10.14670/hh-18-118}
}

@article{holscher2019-31068799,
  author  = {Hölscher, C.},
  title   = {{Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2019},
  doi     = {10.3389/fnagi.2019.00088},
  pmid    = {31068799},
  url     = {https://doi.org/10.3389/fnagi.2019.00088}
}

@article{femminella2019-30944040,
  author  = {Femminella, G. D. and Frangou, E. and Love, S. B. and Busza, G. and Holmes, C. and Ritchie, C. and Lawrence, R. and McFarlane, B. and others},
  title   = {{Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study)}},
  journal = {Trials},
  year    = {2019},
  doi     = {10.1186/s13063-019-3259-x},
  pmid    = {30944040},
  url     = {https://doi.org/10.1186/s13063-019-3259-x}
}

@article{erbil2019-30938196,
  author  = {Erbil, D. and Eren, C. Y. and Demirel, C. and Küçüker, M. U. and Solaroğlu, I. and Eser, H. Y.},
  title   = {{GLP-1's role in neuroprotection: a systematic review}},
  journal = {Brain injury},
  year    = {2019},
  doi     = {10.1080/02699052.2019.1587000},
  pmid    = {30938196},
  url     = {https://doi.org/10.1080/02699052.2019.1587000}
}

@article{batista2019-30511349,
  author  = {Batista, A. F. and Bodart-Santos, V. and De Felice, F. G. and Ferreira, S. T.},
  title   = {{Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases}},
  journal = {CNS drugs},
  year    = {2019},
  doi     = {10.1007/s40263-018-0593-6},
  pmid    = {30511349},
  url     = {https://doi.org/10.1007/s40263-018-0593-6}
}

@article{wicinski2019-30823403,
  author  = {Wiciński, M. and Socha, M. and Malinowski, B. and Wódkiewicz, E. and Walczak, M. and Górski, K. and Słupski, M. and Pawlak-Osińska, K.},
  title   = {{Liraglutide and its Neuroprotective Properties-Focus on Possible Biochemical Mechanisms in Alzheimer's Disease and Cerebral Ischemic Events}},
  journal = {International journal of molecular sciences},
  year    = {2019},
  doi     = {10.3390/ijms20051050},
  pmid    = {30823403},
  url     = {https://doi.org/10.3390/ijms20051050}
}

@article{zhou2019-30773255,
  author  = {Zhou, M. and Chen, S. and Peng, P. and Gu, Z. and Yu, J. and Zhao, G. and Deng, Y.},
  title   = {{Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β}},
  journal = {Biochemical and biophysical research communications},
  year    = {2019},
  doi     = {10.1016/j.bbrc.2019.01.103},
  pmid    = {30773255},
  url     = {https://doi.org/10.1016/j.bbrc.2019.01.103}
}

@article{delamonte2019-30775986,
  author  = {de la Monte, Suzanne M. and Tong, Ming and Daiello, Lori A. and Ott, Brian R.},
  title   = {{Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2019},
  doi     = {10.3233/jad-180906},
  pmid    = {30775986},
  url     = {https://doi.org/10.3233/jad-180906}
}

@article{csajbok2019-30637442,
  author  = {Csajbók, Éva A and Kocsis, Ágnes K and Faragó, Nóra and Furdan, Szabina and Kovács, Balázs and Lovas, Sándor and Molnár, Gábor and Likó, István and others},
  title   = {{Expression of GLP-1 receptors in insulin-containing interneurons of rat cerebral cortex}},
  journal = {Diabetologia},
  year    = {2019},
  doi     = {10.1007/s00125-018-4803-z},
  pmid    = {30637442},
  url     = {https://doi.org/10.1007/s00125-018-4803-z}
}

@article{zhang2019-30632006,
  author  = {Zhang, Yao and Xie, Jia-Zhao and Xu, Xiang-Yang and Hu, Jun and Xu, Teng and Jin, Si and Yang, Shao-Juan and Wang, Jian-Zhi},
  title   = {{Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting}},
  journal = {Neuroscience bulletin},
  year    = {2019},
  doi     = {10.1007/s12264-018-00336-7},
  pmid    = {30632006},
  url     = {https://doi.org/10.1007/s12264-018-00336-7}
}

@article{mullins2019-31518224,
  author  = {Mullins, R. J. and Mustapic, M. and Chia, C. W. and Carlson, O. and Gulyani, S. and Tran, J. and Li, Y. and Mattson, M. P. and others},
  title   = {{A Pilot Study of Exenatide Actions in Alzheimer's Disease}},
  journal = {Current Alzheimer research},
  year    = {2019},
  doi     = {10.2174/1567205016666190913155950},
  pmid    = {31518224},
  url     = {https://doi.org/10.2174/1567205016666190913155950}
}

@article{zhang2019-30684442,
  author  = {Zhang, Z. and Wang, X. and Zhang, D. and Liu, Y. and Li, L.},
  title   = {{Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease}},
  journal = {Aging},
  year    = {2019},
  doi     = {10.18632/aging.101759},
  pmid    = {30684442},
  url     = {https://doi.org/10.18632/aging.101759}
}

@article{zhang2019-31622202,
  author  = {Zhang, Di and Ma, Mingzhu and Liu, Yueze},
  title   = {{Protective Effects of Incretin Against Age-Related Diseases}},
  journal = {Current drug delivery},
  year    = {2019},
  doi     = {10.2174/1567201816666191010145029},
  pmid    = {31622202},
  url     = {https://doi.org/10.2174/1567201816666191010145029}
}

@article{taliyan2019-31333086,
  author  = {Taliyan, Rajeev and Chandran, Sarathlal K and Kakoty, Violina},
  title   = {{Therapeutic Approaches to Alzheimer's Type of Dementia: A Focus on FGF21 Mediated Neuroprotection}},
  journal = {Current pharmaceutical design},
  year    = {2019},
  doi     = {10.2174/1381612825666190716101411},
  pmid    = {31333086},
  url     = {https://doi.org/10.2174/1381612825666190716101411}
}

@article{ohyagi2019-31062332,
  author  = {Ohyagi, Yasumasa and Miyoshi, Katsue and Nakamura, Norimichi},
  title   = {{Therapeutic Strategies for Alzheimer's Disease in the View of Diabetes Mellitus}},
  journal = {Advances in experimental medicine and biology},
  year    = {2019},
  doi     = {10.1007/978-981-13-3540-2_11},
  pmid    = {31062332},
  url     = {https://doi.org/10.1007/978-981-13-3540-2_11}
}

@article{holubova2019-30428311,
  author  = {Holubová, M. and Hrubá, L. and Popelová, A. and Bencze, M. and Pražienková, V. and Gengler, S. and Kratochvílová, H. and Haluzík, M. and others},
  title   = {{Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology}},
  journal = {Neuropharmacology},
  year    = {2019},
  doi     = {10.1016/j.neuropharm.2018.11.002},
  pmid    = {30428311},
  url     = {https://doi.org/10.1016/j.neuropharm.2018.11.002}
}

@article{salles2018-30298718,
  author  = {Salles, Geisa Nogueira and Calió, Michele Longoni and Afewerki, Samson and Pacheco-Soares, Cristina and Porcionatto, Marimelia and Hölscher, Christian and Lobo, Anderson O},
  title   = {{Prolonged Drug-Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis}},
  journal = {ACS applied materials \& interfaces},
  year    = {2018},
  doi     = {10.1021/acsami.8b12649},
  pmid    = {30298718},
  url     = {https://doi.org/10.1021/acsami.8b12649}
}

@article{watson2019-30099030,
  author  = {Watson, K. T. and Wroolie, T. E. and Tong, G. and Foland-Ross, L. C. and Frangou, S. and Singh, M. and McIntyre, R. S. and Roat-Shumway, S. and others},
  title   = {{Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease}},
  journal = {Behavioural brain research},
  year    = {2019},
  doi     = {10.1016/j.bbr.2018.08.006},
  pmid    = {30099030},
  url     = {https://doi.org/10.1016/j.bbr.2018.08.006}
}

@article{camkurt2018-30020885,
  author  = {Camkurt, Mehmet Akif and Lavagnino, Luca and Zhang, Xiang Y and Teixeira, Antonio L},
  title   = {{Liraglutide for psychiatric disorders: clinical evidence and challenges}},
  journal = {Hormone molecular biology and clinical investigation},
  year    = {2018},
  doi     = {10.1515/hmbci-2018-0031},
  pmid    = {30020885},
  url     = {https://doi.org/10.1515/hmbci-2018-0031}
}

@article{moreno2018-29945658,
  author  = {Moreno, Cesar L and Della Guardia, Lucio and Shnyder, Valeria and Ortiz-Virumbrales, Maitane and Kruglikov, Ilya and Zhang, Bin and Schadt, Eric E and Tanzi, Rudolph E and others},
  title   = {{iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0265-5},
  pmid    = {29945658},
  url     = {https://doi.org/10.1186/s13024-018-0265-5}
}

@article{yun2018-29892066,
  author  = {Yun, S. P. and Kam, T. I. and Panicker, N. and Kim, S. and Oh, Y. and Park, J. S. and Kwon, S. H. and others},
  title   = {{Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease}},
  journal = {Nature medicine},
  year    = {2018},
  doi     = {10.1038/s41591-018-0051-5},
  pmid    = {29892066},
  url     = {https://doi.org/10.1038/s41591-018-0051-5}
}

@article{weina2018-29705602,
  author  = {Weina, H. and Yuhu, N. and Christian, H. and Birong, L. and Feiyu, S. and Le, W.},
  title   = {{Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity}},
  journal = {Brain research},
  year    = {2018},
  doi     = {10.1016/j.brainres.2018.04.031},
  pmid    = {29705602},
  url     = {https://doi.org/10.1016/j.brainres.2018.04.031}
}

@article{batista2018-29435980,
  author  = {Batista, A. F. and Forny-Germano, L. and Clarke, JR. and Lyra E Silva, N. M. and Brito-Moreira, J. and Boehnke, S. E. and Winterborn, A. and Coe, B. C. and others},
  title   = {{The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease}},
  journal = {The Journal of pathology},
  year    = {2018},
  doi     = {10.1002/path.5056},
  pmid    = {29435980},
  url     = {https://doi.org/10.1002/path.5056}
}

@article{denver2018-29604345,
  author  = {Denver, P. and English, A. and McClean, P. L.},
  title   = {{Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2018},
  doi     = {10.1016/j.bbi.2018.03.032},
  pmid    = {29604345},
  url     = {https://doi.org/10.1016/j.bbi.2018.03.032}
}

@article{yildirimsimsir2018-29598932,
  author  = {Yildirim Simsir, I. and Soyaltin, U. E. and Cetinkalp, S.},
  title   = {{Glucagon like peptide-1 (GLP-1) likes Alzheimer's disease}},
  journal = {Diabetes \& metabolic syndrome},
  year    = {2018},
  doi     = {10.1016/j.dsx.2018.03.002},
  pmid    = {29598932},
  url     = {https://doi.org/10.1016/j.dsx.2018.03.002}
}

@article{cao2018-29551659,
  author  = {Cao, Y. and Hölscher, C. and Hu, M. M. and Wang, T. and Zhao, F. and Bai, Y. and Zhang, J. and Wu, M. N. and others},
  title   = {{DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease}},
  journal = {European journal of pharmacology},
  year    = {2018},
  doi     = {10.1016/j.ejphar.2018.03.024},
  pmid    = {29551659},
  url     = {https://doi.org/10.1016/j.ejphar.2018.03.024}
}

@article{li2018-29473979,
  author  = {Li, T. and Jiao, J. J. and Hölscher, C. and Wu, M. N. and Zhang, J. and Tong, J. Q. and Dong, X. F. and Qu, X. S. and others},
  title   = {{A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease}},
  journal = {Hippocampus},
  year    = {2018},
  doi     = {10.1002/hipo.22837},
  pmid    = {29473979},
  url     = {https://doi.org/10.1002/hipo.22837}
}

@article{holscher2018-29402504,
  author  = {Hölscher, C.},
  title   = {{Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models}},
  journal = {Neuropharmacology},
  year    = {2018},
  doi     = {10.1016/j.neuropharm.2018.01.040},
  pmid    = {29402504},
  url     = {https://doi.org/10.1016/j.neuropharm.2018.01.040}
}

@article{arnold2018-29377010,
  author  = {Arnold, S. E. and Arvanitakis, Z. and Macauley-Rambach, S. L. and Koenig, A. M. and Wang, H. Y. and Ahima, R. S. and Craft, S. and Gandy, S. and others},
  title   = {{Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums}},
  journal = {Nature reviews. Neurology},
  year    = {2018},
  doi     = {10.1038/nrneurol.2017.185},
  pmid    = {29377010},
  url     = {https://doi.org/10.1038/nrneurol.2017.185}
}

@article{zhang2018-29329976,
  author  = {Zhang, Dongao and Lv, Gang},
  title   = {{Therapeutic potential of spinal GLP-1 receptor signaling}},
  journal = {Peptides},
  year    = {2018},
  doi     = {10.1016/j.peptides.2018.01.003},
  pmid    = {29329976},
  url     = {https://doi.org/10.1016/j.peptides.2018.01.003}
}

@article{bomba2018-29331730,
  author  = {Bomba, M. and Granzotto, A. and Castelli, V. and Massetti, N. and Silvestri, E. and Canzoniero, L. M. T. and Cimini, A. and Sensi, S. L.},
  title   = {{Exenatide exerts cognitive effects by modulating the BDNF-TrkB neurotrophic axis in adult mice}},
  journal = {Neurobiology of aging},
  year    = {2018},
  doi     = {10.1016/j.neurobiolaging.2017.12.009},
  pmid    = {29331730},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.12.009}
}

@article{gejl2017-29235507,
  author  = {Gejl, M. and Brock, B. and Egefjord, L. and Vang, K. and Rungby, J. and Gjedde, A.},
  title   = {{Blood-Brain Glucose Transfer in Alzheimer's disease: Effect of GLP-1 Analog Treatment}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-17718-y},
  pmid    = {29235507},
  url     = {https://doi.org/10.1038/s41598-017-17718-y}
}

@article{cai2018-29175324,
  author  = {Cai, H. Y. and Yang, J. T. and Wang, Z. J. and Zhang, J. and Yang, W. and Wu, M. N. and Qi, J. S.},
  title   = {{Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2018},
  doi     = {10.1016/j.bbrc.2017.11.114},
  pmid    = {29175324},
  url     = {https://doi.org/10.1016/j.bbrc.2017.11.114}
}

@article{bae2017-29165354,
  author  = {Bae, C. S. and Song, J.},
  title   = {{The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain}},
  journal = {International journal of molecular sciences},
  year    = {2017},
  doi     = {10.3390/ijms18112493},
  pmid    = {29165354},
  url     = {https://doi.org/10.3390/ijms18112493}
}

@article{panagaki2017-29170452,
  author  = {Panagaki, Theodora and Michael, Maria and Hölscher, Christian},
  title   = {{Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells}},
  journal = {Scientific Reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-16488-x},
  pmid    = {29170452},
  url     = {https://doi.org/10.1038/s41598-017-16488-x}
}

@article{bianchi2017-29149058,
  author  = {Bianchi, V. E. and Locatelli, V. and Rizzi, L.},
  title   = {{Neurotrophic and Neuroregenerative Effects of GH/IGF1}},
  journal = {International journal of molecular sciences},
  year    = {2017},
  doi     = {10.3390/ijms18112441},
  pmid    = {29149058},
  url     = {https://doi.org/10.3390/ijms18112441}
}

@article{kim2017-29113464,
  author  = {Kim, D. S. and Choi, H. I. and Wang, Y. and Luo, Y. and Hoffer, B. J. and Greig, N. H.},
  title   = {{A New Treatment Strategy for Parkinson's Disease through the Gut-Brain Axis: The Glucagon-Like Peptide-1 Receptor Pathway}},
  journal = {Cell transplantation},
  year    = {2017},
  doi     = {10.1177/0963689717721234},
  pmid    = {29113464},
  url     = {https://doi.org/10.1177/0963689717721234}
}

@article{markowiczpiasecka2017-28589443,
  author  = {Markowicz-Piasecka, M. and Sikora, J. and Szydłowska, A. and Skupień, A. and Mikiciuk-Olasik, E. and Huttunen, K. M.},
  title   = {{Metformin - a Future Therapy for Neurodegenerative Diseases : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla}},
  journal = {Pharmaceutical research},
  year    = {2017},
  doi     = {10.1007/s11095-017-2199-y},
  pmid    = {28589443},
  url     = {https://doi.org/10.1007/s11095-017-2199-y}
}

@article{candeias2018-28573460,
  author  = {Candeias, E. and Sebastião, I. and Cardoso, S. and Carvalho, C. and Santos, M. S. and Oliveira, C. R. and Moreira, P. I. and Duarte, A. I.},
  title   = {{Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats}},
  journal = {Molecular neurobiology},
  year    = {2018},
  doi     = {10.1007/s12035-017-0622-3},
  pmid    = {28573460},
  url     = {https://doi.org/10.1007/s12035-017-0622-3}
}

@article{bassil2017-28334990,
  author  = {Bassil, F. and Canron, M. H. and Vital, A. and Bezard, E. and Li, Y. and Greig, N. H. and Gulyani, S. and Kapogiannis, D. and others},
  title   = {{Insulin resistance and exendin-4 treatment for multiple system atrophy}},
  journal = {Brain : a journal of neurology},
  year    = {2017},
  doi     = {10.1093/brain/awx044},
  pmid    = {28334990},
  url     = {https://doi.org/10.1093/brain/awx044}
}

@article{jalewa2017-28223210,
  author  = {Jalewa, J. and Sharma, M. K. and Gengler, S. and Hölscher, C.},
  title   = {{A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease}},
  journal = {Neuropharmacology},
  year    = {2017},
  doi     = {10.1016/j.neuropharm.2017.02.013},
  pmid    = {28223210},
  url     = {https://doi.org/10.1016/j.neuropharm.2017.02.013}
}

@article{muscogiuri2017-27871675,
  author  = {Muscogiuri, G. and DeFronzo, R. A. and Gastaldelli, A. and Holst, J. J.},
  title   = {{Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes}},
  journal = {Trends in endocrinology and metabolism: TEM},
  year    = {2017},
  doi     = {10.1016/j.tem.2016.10.001},
  pmid    = {27871675},
  url     = {https://doi.org/10.1016/j.tem.2016.10.001}
}

@article{kothari2017-27771511,
  author  = {Kothari, V. and Luo, Y. and Tornabene, T. and O'Neill, A. M. and Greene, M. W. and Geetha, T. and Babu, JR.},
  title   = {{High fat diet induces brain insulin resistance and cognitive impairment in mice}},
  journal = {Biochimica et biophysica acta. Molecular basis of disease},
  year    = {2017},
  doi     = {10.1016/j.bbadis.2016.10.006},
  pmid    = {27771511},
  url     = {https://doi.org/10.1016/j.bbadis.2016.10.006}
}

@article{kosaraju2017-27699599,
  author  = {Kosaraju, J. and Holsinger, R. M. D. and Guo, L. and Tam, K. Y.},
  title   = {{Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer's Disease}},
  journal = {Molecular neurobiology},
  year    = {2017},
  doi     = {10.1007/s12035-016-0125-7},
  pmid    = {27699599},
  url     = {https://doi.org/10.1007/s12035-016-0125-7}
}

@article{hansen2016-27421117,
  author  = {Hansen, Henrik H. and Fabricius, Katrine and Barkholt, Pernille and Wismann, Pernille and Schlumberger, Chantal and Jelsing, Jacob and Terwel, Dick and Termont, Annelies and others},
  title   = {{Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease}},
  journal = {PLoS ONE},
  year    = {2016},
  doi     = {10.1371/journal.pone.0158205},
  pmid    = {27421117},
  url     = {https://doi.org/10.1371/journal.pone.0158205}
}

@article{gejl2016-27252647,
  author  = {Gejl, M. and Gjedde, A. and Egefjord, L. and Møller, A. and Hansen, S. B. and Vang, K. and Rodell, A. and Brændgaard, H. and others},
  title   = {{In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial}},
  journal = {Frontiers in aging neuroscience},
  year    = {2016},
  doi     = {10.3389/fnagi.2016.00108},
  pmid    = {27252647},
  url     = {https://doi.org/10.3389/fnagi.2016.00108}
}

@article{qi2016-27131827,
  author  = {Qi, L. and Ke, L. and Liu, X. and Liao, L. and Ke, S. and Wang, Y. and Lin, X. and others},
  title   = {{Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced alzheimer disease mouse model}},
  journal = {European journal of pharmacology},
  year    = {2016},
  doi     = {10.1016/j.ejphar.2016.04.052},
  pmid    = {27131827},
  url     = {https://doi.org/10.1016/j.ejphar.2016.04.052}
}

@article{bagliettovargas2016-26969101,
  author  = {Baglietto-Vargas, D. and Shi, J. and Yaeger, D. M. and Ager, R. and LaFerla, F. M.},
  title   = {{Diabetes and Alzheimer's disease crosstalk}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2016},
  doi     = {10.1016/j.neubiorev.2016.03.005},
  pmid    = {26969101},
  url     = {https://doi.org/10.1016/j.neubiorev.2016.03.005}
}

@article{athauda2016-26851597,
  author  = {Athauda, D. and Foltynie, T.},
  title   = {{The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action}},
  journal = {Drug discovery today},
  year    = {2016},
  doi     = {10.1016/j.drudis.2016.01.013},
  pmid    = {26851597},
  url     = {https://doi.org/10.1016/j.drudis.2016.01.013}
}

@article{son2016-26967226,
  author  = {Son, Sung Min and Shin, Hong-Joon and Byun, Jayoung and Kook, Sun Young and Moon, Minho and Chang, Yu Jin and Mook-Jung, Inhee},
  title   = {{Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2016},
  doi     = {10.3233/jad-151200},
  pmid    = {26967226},
  url     = {https://doi.org/10.3233/jad-151200}
}

@article{ji2016-26351802,
  author  = {Ji, C. and Xue, G. F. and Li, G. and Li, D. and Hölscher, C.},
  title   = {{Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease}},
  journal = {Reviews in the neurosciences},
  year    = {2016},
  doi     = {10.1515/revneuro-2015-0021},
  pmid    = {26351802},
  url     = {https://doi.org/10.1515/revneuro-2015-0021}
}

@article{bathina2015-26788077,
  author  = {Bathina, S. and Das, U. N.},
  title   = {{Brain-derived neurotrophic factor and its clinical implications}},
  journal = {Archives of medical science : AMS},
  year    = {2015},
  doi     = {10.5114/aoms.2015.56342},
  pmid    = {26788077},
  url     = {https://doi.org/10.5114/aoms.2015.56342}
}

@article{calsolaro2015-26666230,
  author  = {Calsolaro, V. and Edison, P.},
  title   = {{Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer's Disease and Other Neurodegenerative Diseases}},
  journal = {CNS drugs},
  year    = {2015},
  doi     = {10.1007/s40263-015-0301-8},
  pmid    = {26666230},
  url     = {https://doi.org/10.1007/s40263-015-0301-8}
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@article{yang2016-26640240,
  author  = {Yang, Yan and Ma, Delin and Xu, Weijie and Chen, Fuqiong and Du, Tingting and Yue, Wenzhu and Shao, Shiying and Yuan, Gang},
  title   = {{Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level}},
  journal = {Molecular and cellular neurosciences},
  year    = {2016},
  doi     = {10.1016/j.mcn.2015.10.005},
  pmid    = {26640240},
  url     = {https://doi.org/10.1016/j.mcn.2015.10.005}
}

@article{ji2016-26453833,
  author  = {Ji, C. and Xue, G. F. and Lijun, C. and Feng, P. and Li, D. and Li, L. and Li, G. and Hölscher, C.},
  title   = {{A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF}},
  journal = {Brain research},
  year    = {2016},
  doi     = {10.1016/j.brainres.2015.09.035},
  pmid    = {26453833},
  url     = {https://doi.org/10.1016/j.brainres.2015.09.035}
}

@article{solmaz2015-26386291,
  author  = {Solmaz, V. and Çınar, B. P. and Yiğittürk, G. and Çavuşoğlu, T. and Taşkıran, D. and Erbaş, O.},
  title   = {{Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats}},
  journal = {European journal of pharmacology},
  year    = {2015},
  doi     = {10.1016/j.ejphar.2015.09.024},
  pmid    = {26386291},
  url     = {https://doi.org/10.1016/j.ejphar.2015.09.024}
}

@article{ma2015-26183127,
  author  = {Ma, D. L. and Chen, F. Q. and Xu, W. J. and Yue, W. Z. and Yuan, G. and Yang, Y.},
  title   = {{Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice}},
  journal = {Journal of neurochemistry},
  year    = {2015},
  doi     = {10.1111/jnc.13248},
  pmid    = {26183127},
  url     = {https://doi.org/10.1111/jnc.13248}
}

@article{mcclean2015-26205827,
  author  = {McClean, P. L. and Jalewa, J. and Hölscher, C.},
  title   = {{Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice}},
  journal = {Behavioural brain research},
  year    = {2015},
  doi     = {10.1016/j.bbr.2015.07.024},
  pmid    = {26205827},
  url     = {https://doi.org/10.1016/j.bbr.2015.07.024}
}

@article{liu2015-26141845,
  author  = {Liu, W. and Jalewa, J. and Sharma, M. and Li, G. and Li, L. and Hölscher, C.},
  title   = {{Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease}},
  journal = {Neuroscience},
  year    = {2015},
  doi     = {10.1016/j.neuroscience.2015.06.054},
  pmid    = {26141845},
  url     = {https://doi.org/10.1016/j.neuroscience.2015.06.054}
}

@article{sridhar2015-26069723,
  author  = {Sridhar, G. R. and Lakshmi, G. and Nagamani, G.},
  title   = {{Emerging links between type 2 diabetes and Alzheimer's disease}},
  journal = {World journal of diabetes},
  year    = {2015},
  doi     = {10.4239/wjd.v6.i5.744},
  pmid    = {26069723},
  url     = {https://doi.org/10.4239/wjd.v6.i5.744}
}

@article{candeias2015-26131323,
  author  = {Candeias, E. M. and Sebastião, I. C. and Cardoso, S. M. and Correia, S. C. and Carvalho, C. I. and Plácido, A. I. and Santos, M. S. and Oliveira, C. R. and others},
  title   = {{Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide}},
  journal = {World journal of diabetes},
  year    = {2015},
  doi     = {10.4239/wjd.v6.i6.807},
  pmid    = {26131323},
  url     = {https://doi.org/10.4239/wjd.v6.i6.807}
}

@article{li2015-25792818,
  author  = {Li, X. and Song, D. and Leng, S. X.},
  title   = {{Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment}},
  journal = {Clinical interventions in aging},
  year    = {2015},
  doi     = {10.2147/cia.s74042},
  pmid    = {25792818},
  url     = {https://doi.org/10.2147/cia.s74042}
}

@article{claxton2015-25374101,
  author  = {Claxton, Amy and Baker, Laura D. and Hanson, Angela J. and Trittschuh, Emily H. and Cholerton, Brenna and Morgan, Amy and Callaghan, Maureen and Arbuckle, Matthew and others},
  title   = {{Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2015},
  doi     = {10.3233/jad-141791},
  pmid    = {25374101},
  url     = {https://doi.org/10.3233/jad-141791}
}

@article{nassar2015-25446674,
  author  = {Nassar, N. N. and Al-Shorbagy, M. Y. and Arab, H. H. and Abdallah, D. M.},
  title   = {{Saxagliptin: a novel antiparkinsonian approach}},
  journal = {Neuropharmacology},
  year    = {2015},
  doi     = {10.1016/j.neuropharm.2014.10.007},
  pmid    = {25446674},
  url     = {https://doi.org/10.1016/j.neuropharm.2014.10.007}
}

@article{yamagishi2015-25582643,
  author  = {Yamagishi, S. and Fukami, K. and Matsui, T.},
  title   = {{Crosstalk between advanced glycation end products (AGEs)-receptor RAGE axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications}},
  journal = {Cardiovascular diabetology},
  year    = {2015},
  doi     = {10.1186/s12933-015-0176-5},
  pmid    = {25582643},
  url     = {https://doi.org/10.1186/s12933-015-0176-5}
}

@article{hansen2015-25869785,
  author  = {Hansen, H. H. and Fabricius, K. and Barkholt, P. and Niehoff, M. L. and Morley, J. E. and Jelsing, J. and Pyke, C. and Knudsen, L. B. and others},
  title   = {{The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2015},
  doi     = {10.3233/jad-143090},
  pmid    = {25869785},
  url     = {https://doi.org/10.3233/jad-143090}
}

@article{mcclean2014-25107586,
  author  = {McClean, P. L. and Hölscher, C.},
  title   = {{Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease}},
  journal = {Neuropharmacology},
  year    = {2014},
  doi     = {10.1016/j.neuropharm.2014.07.015},
  pmid    = {25107586},
  url     = {https://doi.org/10.1016/j.neuropharm.2014.07.015}
}

@article{sebastiao2014-25071725,
  author  = {Sebastião, I. and Candeias, E. and Santos, M. S. and de Oliveira, C. R. and Moreira, P. I. and Duarte, A. I.},
  title   = {{Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease - How Anti-Diabetics Could be a Solution for Dementia}},
  journal = {Frontiers in endocrinology},
  year    = {2014},
  doi     = {10.3389/fendo.2014.00110},
  pmid    = {25071725},
  url     = {https://doi.org/10.3389/fendo.2014.00110}
}

@article{holscher2014-24646283,
  author  = {Hölscher, C.},
  title   = {{Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases}},
  journal = {Biochemical Society transactions},
  year    = {2014},
  doi     = {10.1042/bst20140016},
  pmid    = {24646283},
  url     = {https://doi.org/10.1042/bst20140016}
}

@article{holscher2014-23999914,
  author  = {Hölscher, C.},
  title   = {{Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases}},
  journal = {The Journal of endocrinology},
  year    = {2014},
  doi     = {10.1530/joe-13-0221},
  pmid    = {23999914},
  url     = {https://doi.org/10.1530/joe-13-0221}
}

@article{bassil2014-24582776,
  author  = {Bassil, F. and Fernagut, P. O. and Bezard, E. and Meissner, W. G.},
  title   = {{Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?}},
  journal = {Progress in neurobiology},
  year    = {2014},
  doi     = {10.1016/j.pneurobio.2014.02.005},
  pmid    = {24582776},
  url     = {https://doi.org/10.1016/j.pneurobio.2014.02.005}
}

@article{cai2014-24583037,
  author  = {Cai, H. Y. and Hölscher, C. and Yue, X. H. and Zhang, S. X. and Wang, X. H. and Qiao, F. and Yang, W. and Qi, J. S.},
  title   = {{Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats}},
  journal = {Neuroscience},
  year    = {2014},
  doi     = {10.1016/j.neuroscience.2014.02.022},
  pmid    = {24583037},
  url     = {https://doi.org/10.1016/j.neuroscience.2014.02.022}
}

@article{tseng2014-24322626,
  author  = {Tseng, C. L. and Soroka, O. and Maney, M. and Aron, D. C. and Pogach, L. M.},
  title   = {{Assessing potential glycemic overtreatment in persons at hypoglycemic risk}},
  journal = {JAMA internal medicine},
  year    = {2014},
  doi     = {10.1001/jamainternmed.2013.12963},
  pmid    = {24322626},
  url     = {https://doi.org/10.1001/jamainternmed.2013.12963}
}

@article{holscher2014-24529525,
  author  = {Hölscher, C.},
  title   = {{The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2014},
  doi     = {10.1016/j.jalz.2013.12.009},
  pmid    = {24529525},
  url     = {https://doi.org/10.1016/j.jalz.2013.12.009}
}

@article{talbot2014-24529520,
  author  = {Talbot, K. and Wang, H. Y.},
  title   = {{The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2014},
  doi     = {10.1016/j.jalz.2013.12.007},
  pmid    = {24529520},
  url     = {https://doi.org/10.1016/j.jalz.2013.12.007}
}

@article{iwai2014-24464856,
  author  = {Iwai, Takashi and Sawabe, Toshihiro and Tanimitsu, Kahori and Suzuki, Manabu and Sasaki-Hamada, Sachie and Oka, Jun-Ichiro},
  title   = {{Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents}},
  journal = {Journal of neuroscience research},
  year    = {2014},
  doi     = {10.1002/jnr.23335},
  pmid    = {24464856},
  url     = {https://doi.org/10.1002/jnr.23335}
}

@article{seufert2014-24373150,
  author  = {Seufert, J. and Gallwitz, B.},
  title   = {{The extra-pancreatic effects of GLP-1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems}},
  journal = {Diabetes, obesity \& metabolism},
  year    = {2014},
  doi     = {10.1111/dom.12251},
  pmid    = {24373150},
  url     = {https://doi.org/10.1111/dom.12251}
}

@article{patrone2014-24622756,
  author  = {Patrone, C. and Eriksson, O. and Lindholm, D.},
  title   = {{Diabetes drugs and neurological disorders: new views and therapeutic possibilities}},
  journal = {The lancet. Diabetes \& endocrinology},
  year    = {2014},
  doi     = {10.1016/s2213-8587(13)70125-6},
  pmid    = {24622756},
  url     = {https://doi.org/10.1016/s2213-8587(13)70125-6}
}

@article{chen2014-24183963,
  author  = {Chen, S. and An, F. M. and Yin, L. and Liu, A. R. and Yin, D. K. and Yao, W. B. and Gao, X. D.},
  title   = {{Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation}},
  journal = {Neuroscience},
  year    = {2014},
  doi     = {10.1016/j.neuroscience.2013.10.038},
  pmid    = {24183963},
  url     = {https://doi.org/10.1016/j.neuroscience.2013.10.038}
}

@article{sharma2014-24112036,
  author  = {Sharma, M. K. and Jalewa, J. and Hölscher, C.},
  title   = {{Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress}},
  journal = {Journal of neurochemistry},
  year    = {2014},
  doi     = {10.1111/jnc.12469},
  pmid    = {24112036},
  url     = {https://doi.org/10.1111/jnc.12469}
}

@article{kosaraju2013-24117480,
  author  = {Kosaraju, J. and Murthy, V. and Khatwal, R. B. and Dubala, A. and Chinni, S. and Muthureddy Nataraj, S. K. and Basavan, D.},
  title   = {{Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease}},
  journal = {The Journal of pharmacy and pharmacology},
  year    = {2013},
  doi     = {10.1111/jphp.12148},
  pmid    = {24117480},
  url     = {https://doi.org/10.1111/jphp.12148}
}

@article{mcclean2014-23973293,
  author  = {McClean, P. L. and Hölscher, C.},
  title   = {{Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease}},
  journal = {Neuropharmacology},
  year    = {2014},
  doi     = {10.1016/j.neuropharm.2013.08.005},
  pmid    = {23973293},
  url     = {https://doi.org/10.1016/j.neuropharm.2013.08.005}
}

@article{bomba2013-23640454,
  author  = {Bomba, M. and Ciavardelli, D. and Silvestri, E. and Canzoniero, L. M. and Lattanzio, R. and Chiappini, P. and Piantelli, M. and Di Ilio, C. and others},
  title   = {{Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals}},
  journal = {Cell death \& disease},
  year    = {2013},
  doi     = {10.1038/cddis.2013.139},
  pmid    = {23640454},
  url     = {https://doi.org/10.1038/cddis.2013.139}
}

@article{faivre2013-23601582,
  author  = {Faivre, E. and Hölscher, C.},
  title   = {{Neuroprotective effects of D-Ala(2)GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model}},
  journal = {Alzheimer's research \& therapy},
  year    = {2013},
  doi     = {10.1186/alzrt174},
  pmid    = {23601582},
  url     = {https://doi.org/10.1186/alzrt174}
}

@article{kosaraju2013-23603201,
  author  = {Kosaraju, J. and Gali, C. C. and Khatwal, R. B. and Dubala, A. and Chinni, S. and Holsinger, R. M. and Madhunapantula, V. S. and Muthureddy Nataraj, S. K. and others},
  title   = {{Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease}},
  journal = {Neuropharmacology},
  year    = {2013},
  doi     = {10.1016/j.neuropharm.2013.04.008},
  pmid    = {23603201},
  url     = {https://doi.org/10.1016/j.neuropharm.2013.04.008}
}

@article{parthsarathy2013-23536825,
  author  = {Parthsarathy, V. and Hölscher, C.},
  title   = {{Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0058784},
  pmid    = {23536825},
  url     = {https://doi.org/10.1371/journal.pone.0058784}
}

@article{duarte2013-23314196,
  author  = {Duarte, A. I. and Candeias, E. and Correia, S. C. and Santos, R. X. and Carvalho, C. and Cardoso, S. and Plácido, A. and Santos, M. S. and others},
  title   = {{Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration}},
  journal = {Biochimica et biophysica acta},
  year    = {2013},
  doi     = {10.1016/j.bbadis.2013.01.008},
  pmid    = {23314196},
  url     = {https://doi.org/10.1016/j.bbadis.2013.01.008}
}

@article{yang2013-23948890,
  author  = {Yang, Y. and Zhang, J. and Ma, D. and Zhang, M. and Hu, S. and Shao, S. and Gong, C. X.},
  title   = {{Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-130491},
  pmid    = {23948890},
  url     = {https://doi.org/10.3233/jad-130491}
}

@article{parthsarathy2013-23276669,
  author  = {Parthsarathy, V. and Hölscher, C.},
  title   = {{The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain}},
  journal = {European journal of pharmacology},
  year    = {2013},
  doi     = {10.1016/j.ejphar.2012.12.012},
  pmid    = {23276669},
  url     = {https://doi.org/10.1016/j.ejphar.2012.12.012}
}

@article{duffy2013-23103794,
  author  = {Duffy, A. M. and Hölscher, C.},
  title   = {{The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease}},
  journal = {Neuroscience},
  year    = {2013},
  doi     = {10.1016/j.neuroscience.2012.10.045},
  pmid    = {23103794},
  url     = {https://doi.org/10.1016/j.neuroscience.2012.10.045}
}

@article{tweedie2013-23059457,
  author  = {Tweedie, D. and Rachmany, L. and Rubovitch, V. and Lehrmann, E. and Zhang, Y. and Becker, K. G. and Perez, E. and Miller, J. and others},
  title   = {{Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice}},
  journal = {Experimental neurology},
  year    = {2013},
  doi     = {10.1016/j.expneurol.2012.10.001},
  pmid    = {23059457},
  url     = {https://doi.org/10.1016/j.expneurol.2012.10.001}
}

@article{ma2012-23035082,
  author  = {Ma, T. and Du, X. and Pick, J. E. and Sui, G. and Brownlee, M. and Klann, E.},
  title   = {{Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.2107-12.2012},
  pmid    = {23035082},
  url     = {https://doi.org/10.1523/jneurosci.2107-12.2012}
}

@article{holscher2012-22938097,
  author  = {Hölscher, C.},
  title   = {{Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection}},
  journal = {CNS drugs},
  year    = {2012},
  doi     = {10.2165/11635890-000000000-00000},
  pmid    = {22938097},
  url     = {https://doi.org/10.2165/11635890-000000000-00000}
}

@article{longsmith2013-23011726,
  author  = {Long-Smith, C. M. and Manning, S. and McClean, P. L. and Coakley, M. F. and O'Halloran, D. J. and Holscher, C. and O'Neill, C.},
  title   = {{The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease}},
  journal = {Neuromolecular medicine},
  year    = {2013},
  doi     = {10.1007/s12017-012-8199-5},
  pmid    = {23011726},
  url     = {https://doi.org/10.1007/s12017-012-8199-5}
}

@article{mcintyre2013-23000536,
  author  = {McIntyre, R. S. and Powell, A. M. and Kaidanovich-Beilin, O. and Soczynska, J. K. and Alsuwaidan, M. and Woldeyohannes, H. O. and Kim, A. S. and Gallaugher, L. A.},
  title   = {{The neuroprotective effects of GLP-1: possible treatments for cognitive deficits in individuals with mood disorders}},
  journal = {Behavioural brain research},
  year    = {2013},
  doi     = {10.1016/j.bbr.2012.09.021},
  pmid    = {23000536},
  url     = {https://doi.org/10.1016/j.bbr.2012.09.021}
}

@article{clark2012-22966039,
  author  = {Clark, I. and Atwood, C. and Bowen, R. and Paz-Filho, G. and Vissel, B.},
  title   = {{Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales}},
  journal = {Pharmacological reviews},
  year    = {2012},
  doi     = {10.1124/pr.112.005850},
  pmid    = {22966039},
  url     = {https://doi.org/10.1124/pr.112.005850}
}

@article{gejl2012-22929437,
  author  = {Gejl, Michael and Egefjord, Lærke and Lerche, Susanne Søgaard and Vang, Kim and Bibby, Bo Martin and Holst, Jens Juul and Mengel, Annette and Møller, Niels and others},
  title   = {{Glucagon-Like Peptide-1 Decreases Intracerebral Glucose Content by Activating Hexokinase and Changing Glucose Clearance during Hyperglycemia}},
  journal = {Journal of Cerebral Blood Flow \& Metabolism},
  year    = {2012},
  doi     = {10.1038/jcbfm.2012.118},
  pmid    = {22929437},
  url     = {https://doi.org/10.1038/jcbfm.2012.118}
}

@article{rachmany2013-22892942,
  author  = {Rachmany, L. and Tweedie, D. and Li, Y. and Rubovitch, V. and Holloway, H. W. and Miller, J. and Hoffer, B. J. and Greig, N. H. and others},
  title   = {{Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice}},
  journal = {Age (Dordrecht, Netherlands)},
  year    = {2013},
  doi     = {10.1007/s11357-012-9464-0},
  pmid    = {22892942},
  url     = {https://doi.org/10.1007/s11357-012-9464-0}
}

@article{huang2012-22844396,
  author  = {Huang, H. J. and Chen, Y. H. and Liang, K. C. and Jheng, Y. S. and Jhao, J. J. and Su, M. T. and Lee-Chen, G. J. and Hsieh-Li, H. M.},
  title   = {{Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0039656},
  pmid    = {22844396},
  url     = {https://doi.org/10.1371/journal.pone.0039656}
}

@article{banks2012-22820012,
  author  = {Banks, W. A. and Owen, J. B. and Erickson, M. A.},
  title   = {{Insulin in the brain: there and back again}},
  journal = {Pharmacology \& therapeutics},
  year    = {2012},
  doi     = {10.1016/j.pharmthera.2012.07.006},
  pmid    = {22820012},
  url     = {https://doi.org/10.1016/j.pharmthera.2012.07.006}
}

@article{salcedo2012-22519295,
  author  = {Salcedo, I. and Tweedie, D. and Li, Y. and Greig, N. H.},
  title   = {{Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders}},
  journal = {British journal of pharmacology},
  year    = {2012},
  doi     = {10.1111/j.1476-5381.2012.01971.x},
  pmid    = {22519295},
  url     = {https://doi.org/10.1111/j.1476-5381.2012.01971.x}
}

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  year    = {2012},
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@article{han2013-22592020,
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  title   = {{Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2012.04.009},
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@article{bomfim2012-22476196,
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  title   = {{An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers}},
  journal = {The Journal of clinical investigation},
  year    = {2012},
  doi     = {10.1172/jci57256},
  pmid    = {22476196},
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@article{talbot2012-22476197,
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  title   = {{Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline}},
  journal = {The Journal of clinical investigation},
  year    = {2012},
  doi     = {10.1172/jci59903},
  pmid    = {22476197},
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}

@article{hunter2012-22443187,
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  title   = {{Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis}},
  journal = {BMC neuroscience},
  year    = {2012},
  doi     = {10.1186/1471-2202-13-33},
  pmid    = {22443187},
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}

@article{li2012-22425595,
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  title   = {{Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice}},
  journal = {Pharmacology, biochemistry, and behavior},
  year    = {2012},
  doi     = {10.1016/j.pbb.2012.03.002},
  pmid    = {22425595},
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}

@article{li2012-22384126,
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  title   = {{Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis}},
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  year    = {2012},
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  pmid    = {22384126},
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@article{avilesolmos2013-22344583,
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  title   = {{Parkinson's disease, insulin resistance and novel agents of neuroprotection}},
  journal = {Brain : a journal of neurology},
  year    = {2013},
  doi     = {10.1093/brain/aws009},
  pmid    = {22344583},
  url     = {https://doi.org/10.1093/brain/aws009}
}

@article{gao2011-22718609,
  author  = {Gao, C. and Hölscher, C. and Liu, Y. and Li, L.},
  title   = {{GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease}},
  journal = {Reviews in the neurosciences},
  year    = {2011},
  doi     = {10.1515/rns.2011.061},
  pmid    = {22718609},
  url     = {https://doi.org/10.1515/rns.2011.061}
}

@article{faivre2012-22115896,
  author  = {Faivre, E. and Hamilton, A. and Hölscher, C.},
  title   = {{Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice}},
  journal = {European journal of pharmacology},
  year    = {2012},
  doi     = {10.1016/j.ejphar.2011.11.007},
  pmid    = {22115896},
  url     = {https://doi.org/10.1016/j.ejphar.2011.11.007}
}

@article{holscher2011-21787319,
  author  = {Hölscher, C.},
  title   = {{Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease}},
  journal = {Biochemical Society transactions},
  year    = {2011},
  doi     = {10.1042/bst0390891},
  pmid    = {21787319},
  url     = {https://doi.org/10.1042/bst0390891}
}

@article{gupta2011-21277873,
  author  = {Gupta, A. and Bisht, B. and Dey, C. S.},
  title   = {{Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes}},
  journal = {Neuropharmacology},
  year    = {2011},
  doi     = {10.1016/j.neuropharm.2011.01.033},
  pmid    = {21277873},
  url     = {https://doi.org/10.1016/j.neuropharm.2011.01.033}
}

@article{holst2011-21222567,
  author  = {Holst, J. J. and Burcelin, R. and Nathanson, E.},
  title   = {{Neuroprotective properties of GLP-1: theoretical and practical applications}},
  journal = {Current medical research and opinion},
  year    = {2011},
  doi     = {10.1185/03007995.2010.549466},
  pmid    = {21222567},
  url     = {https://doi.org/10.1185/03007995.2010.549466}
}

@article{hamilton2011-21312223,
  author  = {Hamilton, A. and Patterson, S. and Porter, D. and Gault, V. A. and Holscher, C.},
  title   = {{Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain}},
  journal = {Journal of neuroscience research},
  year    = {2011},
  doi     = {10.1002/jnr.22565},
  pmid    = {21312223},
  url     = {https://doi.org/10.1002/jnr.22565}
}

@article{wang2010-20727946,
  author  = {Wang, X. H. and Li, L. and Hölscher, C. and Pan, Y. F. and Chen, X. R. and Qi, J. S.},
  title   = {{Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats}},
  journal = {Neuroscience},
  year    = {2010},
  doi     = {10.1016/j.neuroscience.2010.08.028},
  pmid    = {20727946},
  url     = {https://doi.org/10.1016/j.neuroscience.2010.08.028}
}

@article{irwin2010-20698813,
  author  = {Irwin, Nigel and Gault, Victor A. and Flatt, Peter R.},
  title   = {{Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?}},
  journal = {Expert Opinion on Investigational Drugs},
  year    = {2010},
  doi     = {10.1517/13543784.2010.513381},
  pmid    = {20698813},
  url     = {https://doi.org/10.1517/13543784.2010.513381}
}

@article{holscher2010-20337586,
  author  = {Holscher, C.},
  title   = {{Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease}},
  journal = {Recent patents on CNS drug discovery},
  year    = {2010},
  doi     = {10.2174/157488910791213130},
  pmid    = {20337586},
  url     = {https://doi.org/10.2174/157488910791213130}
}

@article{gengler2012-20359773,
  author  = {Gengler, S. and McClean, P. L. and McCurtin, R. and Gault, V. A. and Hölscher, C.},
  title   = {{Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2010.02.014},
  pmid    = {20359773},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2010.02.014}
}

@article{takeda2010-20231468,
  author  = {Takeda, Shuko and Sato, Naoyuki and Uchio‐Yamada, Kozue and Sawada, Kyoko and Kunieda, Takanori and Takeuchi, Daisuke and Kurinami, Hitomi and Shinohara, Mitsuru and others},
  title   = {{Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {2010},
  doi     = {10.1073/pnas.1000645107},
  pmid    = {20231468},
  url     = {https://doi.org/10.1073/pnas.1000645107}
}

@article{moloney2010-18479783,
  author  = {Moloney, A. M. and Griffin, R. J. and Timmons, S. and O'Connor, R. and Ravid, R. and O'Neill, C.},
  title   = {{Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling}},
  journal = {Neurobiology of aging},
  year    = {2010},
  doi     = {10.1016/j.neurobiolaging.2008.04.002},
  pmid    = {18479783},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2008.04.002}
}

@article{harkavyi2010-20128800,
  author  = {Harkavyi, A. and Whitton, P. S.},
  title   = {{Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection}},
  journal = {British journal of pharmacology},
  year    = {2010},
  doi     = {10.1111/j.1476-5381.2009.00486.x},
  pmid    = {20128800},
  url     = {https://doi.org/10.1111/j.1476-5381.2009.00486.x}
}

@article{li2010-20308787,
  author  = {Li, Y. and Duffy, K. B. and Ottinger, M. A. and Ray, B. and Bailey, J. A. and Holloway, H. W. and Tweedie, D. and Perry, T. and others},
  title   = {{GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2010},
  doi     = {10.3233/jad-2010-1314},
  pmid    = {20308787},
  url     = {https://doi.org/10.3233/jad-2010-1314}
}

@article{holscher2010-21094907,
  author  = {Hölscher, C.},
  title   = {{The role of GLP-1 in neuronal activity and neurodegeneration}},
  journal = {Vitamins and hormones},
  year    = {2010},
  doi     = {10.1016/b978-0-12-381517-0.00013-8},
  pmid    = {21094907},
  url     = {https://doi.org/10.1016/b978-0-12-381517-0.00013-8}
}

@article{mcclean2010-20035739,
  author  = {McClean, P. L. and Gault, V. A. and Harriott, P. and Hölscher, C.},
  title   = {{Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease}},
  journal = {European journal of pharmacology},
  year    = {2010},
  doi     = {10.1016/j.ejphar.2009.12.023},
  pmid    = {20035739},
  url     = {https://doi.org/10.1016/j.ejphar.2009.12.023}
}

@article{damico2010-20005285,
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  title   = {{Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice}},
  journal = {Experimental gerontology},
  year    = {2010},
  doi     = {10.1016/j.exger.2009.12.004},
  pmid    = {20005285},
  url     = {https://doi.org/10.1016/j.exger.2009.12.004}
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@article{ma2009-19605645,
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  title   = {{Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.1071-09.2009},
  pmid    = {19605645},
  url     = {https://doi.org/10.1523/jneurosci.1071-09.2009}
}

@article{abbas2009-19573562,
  author  = {Abbas, T. and Faivre, E. and Hölscher, C.},
  title   = {{Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease}},
  journal = {Behavioural brain research},
  year    = {2009},
  doi     = {10.1016/j.bbr.2009.06.035},
  pmid    = {19573562},
  url     = {https://doi.org/10.1016/j.bbr.2009.06.035}
}

@article{kimura2009-19463904,
  author  = {Kimura, R. and Okouchi, M. and Fujioka, H. and Ichiyanagi, A. and Ryuge, F. and Mizuno, T. and Imaeda, K. and Okayama, N. and others},
  title   = {{Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway}},
  journal = {Neuroscience},
  year    = {2009},
  doi     = {10.1016/j.neuroscience.2009.05.025},
  pmid    = {19463904},
  url     = {https://doi.org/10.1016/j.neuroscience.2009.05.025}
}

@article{maher2009-19402773,
  author  = {Maher, Pamela A and Schubert, David R},
  title   = {{Metabolic links between diabetes and Alzheimer's disease}},
  journal = {Expert review of neurotherapeutics},
  year    = {2009},
  doi     = {10.1586/ern.09.18},
  pmid    = {19402773},
  url     = {https://doi.org/10.1586/ern.09.18}
}

@article{chen2009-19237574,
  author  = {Chen, Y. and Zhou, K. and Wang, R. and Liu, Y. and Kwak, Y. D. and Ma, T. and Thompson, R. C. and Zhao, Y. and others},
  title   = {{Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0807991106},
  pmid    = {19237574},
  url     = {https://doi.org/10.1073/pnas.0807991106}
}

@article{defelice2009-19188609,
  author  = {De Felice, F. G. and Vieira, M. N. and Bomfim, T. R. and Decker, H. and Velasco, P. T. and Lambert, M. P. and Viola, K. L. and Zhao, W. Q. and others},
  title   = {{Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0809158106},
  pmid    = {19188609},
  url     = {https://doi.org/10.1073/pnas.0809158106}
}

@article{holscher2010-18930564,
  author  = {Hölscher, C. and Li, L.},
  title   = {{New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?}},
  journal = {Neurobiology of aging},
  year    = {2010},
  doi     = {10.1016/j.neurobiolaging.2008.08.023},
  pmid    = {18930564},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2008.08.023}
}

@article{qin2008-18760331,
  author  = {Qin, Z. and Sun, Z. and Huang, J. and Hu, Y. and Wu, Z. and Mei, B.},
  title   = {{Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42)}},
  journal = {Neuroscience letters},
  year    = {2008},
  doi     = {10.1016/j.neulet.2008.08.047},
  pmid    = {18760331},
  url     = {https://doi.org/10.1016/j.neulet.2008.08.047}
}

@article{reger2008-18430999,
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  title   = {{Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2008},
  doi     = {10.3233/jad-2008-13309},
  pmid    = {18430999},
  url     = {https://doi.org/10.3233/jad-2008-13309}
}

@article{gault2008-18466898,
  author  = {Gault, V. A. and Hölscher, C.},
  title   = {{GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid}},
  journal = {European journal of pharmacology},
  year    = {2008},
  doi     = {10.1016/j.ejphar.2008.03.025},
  pmid    = {18466898},
  url     = {https://doi.org/10.1016/j.ejphar.2008.03.025}
}

@article{zhao2008-17720802,
  author  = {Zhao, W. Q. and De Felice, F. G. and Fernandez, S. and Chen, H. and Lambert, M. P. and Quon, M. J. and Krafft, G. A. and others},
  title   = {{Amyloid beta oligomers induce impairment of neuronal insulin receptors}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2008},
  doi     = {10.1096/fj.06-7703com},
  pmid    = {17720802},
  url     = {https://doi.org/10.1096/fj.06-7703com}
}

@article{liu2007-17629357,
  author  = {Liu, J. and Yin, F. and Zheng, X. and Jing, J. and Hu, Y.},
  title   = {{Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway}},
  journal = {Neurochemistry international},
  year    = {2007},
  doi     = {10.1016/j.neuint.2007.04.021},
  pmid    = {17629357},
  url     = {https://doi.org/10.1016/j.neuint.2007.04.021}
}

@article{lestercoll2006-16627931,
  author  = {Lester-Coll, N. and Rivera, E. J. and Soscia, S. J. and Doiron, K. and Wands, JR. and de la Monte, S. M.},
  title   = {{Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2006},
  doi     = {10.3233/jad-2006-9102},
  pmid    = {16627931},
  url     = {https://doi.org/10.3233/jad-2006-9102}
}

@article{haan2006-16932542,
  author  = {Haan, M. N.},
  title   = {{Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease}},
  journal = {Nature clinical practice. Neurology},
  year    = {2006},
  doi     = {10.1038/ncpneuro0124},
  pmid    = {16932542},
  url     = {https://doi.org/10.1038/ncpneuro0124}
}

@article{rivera2005-16340083,
  author  = {Rivera, E. J. and Goldin, A. and Fulmer, N. and Tavares, R. and Wands, JR. and de la Monte, S. M.},
  title   = {{Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2005},
  doi     = {10.3233/jad-2005-8304},
  pmid    = {16340083},
  url     = {https://doi.org/10.3233/jad-2005-8304}
}

@article{perry2005-15974903,
  author  = {Perry, T. and Greig, N. H.},
  title   = {{Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease}},
  journal = {Current Alzheimer research},
  year    = {2005},
  doi     = {10.2174/1567205054367892},
  pmid    = {15974903},
  url     = {https://doi.org/10.2174/1567205054367892}
}

@article{reger2006-15964100,
  author  = {Reger, M. A. and Watson, G. S. and Frey, W. H. and Baker, L. D. and Cholerton, B. and Keeling, M. L. and Belongia, D. A. and Fishel, M. A. and others},
  title   = {{Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype}},
  journal = {Neurobiology of aging},
  year    = {2006},
  doi     = {10.1016/j.neurobiolaging.2005.03.016},
  pmid    = {15964100},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2005.03.016}
}

@article{steen2005-15750215,
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  title   = {{Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2005},
  doi     = {10.3233/jad-2005-7107},
  pmid    = {15750215},
  url     = {https://doi.org/10.3233/jad-2005-7107}
}

@article{martin2005-16052036,
  author  = {Martin, B. and Lopez de Maturana, R. and Brenneman, R. and Walent, T. and Mattson, M. P. and Maudsley, S.},
  title   = {{Class II G protein-coupled receptors and their ligands in neuronal function and protection}},
  journal = {Neuromolecular medicine},
  year    = {2005},
  doi     = {10.1385/nmm:7:1-2:003},
  pmid    = {16052036},
  url     = {https://doi.org/10.1385/nmm:7:1-2:003}
}

@article{benedict2004-15288712,
  author  = {Benedict, C. and Hallschmid, M. and Hatke, A. and Schultes, B. and Fehm, H. L. and Born, J. and Kern, W.},
  title   = {{Intranasal insulin improves memory in humans}},
  journal = {Psychoneuroendocrinology},
  year    = {2004},
  doi     = {10.1016/j.psyneuen.2004.04.003},
  pmid    = {15288712},
  url     = {https://doi.org/10.1016/j.psyneuen.2004.04.003}
}

@article{meijer2004-15559249,
  author  = {Meijer, L. and Flajolet, M. and Greengard, P.},
  title   = {{Pharmacological inhibitors of glycogen synthase kinase 3}},
  journal = {Trends in pharmacological sciences},
  year    = {2004},
  doi     = {10.1016/j.tips.2004.07.006},
  pmid    = {15559249},
  url     = {https://doi.org/10.1016/j.tips.2004.07.006}
}

@article{perry2004-15270203,
  author  = {Perry, T. A. and Greig, N. H.},
  title   = {{A new Alzheimer's disease interventive strategy: GLP-1}},
  journal = {Current drug targets},
  year    = {2004},
  doi     = {10.2174/1389450043345245},
  pmid    = {15270203},
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