% alzhub.org topic: Drug trials: efficacy and safety
% Source: https://alzhub.org/topic/efficacy-safety
% 902 entries, in the order the page lists them. Built from alzhub.org's own records.
% 4 entries have no readable author in the source record and carry no author field.

@article{yaari2025-40955720,
  author  = {Yaari, Roy and Holdridge, Karen C and Williamson, Melissa and Wessels, Alette M and Shcherbinin, Sergey and Kotari, Vikas and Reiman, Eric M and Tariot, Pierre N and others},
  title   = {{Donanemab in preclinical Alzheimer's disease: Screening and baseline data from TRAILBLAZER-ALZ 3}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70662},
  pmid    = {40955720},
  url     = {https://doi.org/10.1002/alz.70662}
}

@article{tonegawakuji2025-40163534,
  author  = {Tonegawa-Kuji, R. and Hou, Y. and Hu, B. and Lorincz-Comi, N. and Pieper, A. A. and Tousi, B. and Leverenz, J. B. and Cheng, F.},
  title   = {{Efficacy and safety of passive immunotherapies targeting amyloid beta in Alzheimer's disease: A systematic review and meta-analysis}},
  journal = {PLoS medicine},
  year    = {2025},
  doi     = {10.1371/journal.pmed.1004568},
  pmid    = {40163534},
  url     = {https://doi.org/10.1371/journal.pmed.1004568}
}

@article{javed2026-42605139,
  author  = {Javed, Muhammad Nouman and Khan, Saim Mahmood and Mustafa, Smaher and Mujtaba, Amna and Amin, Hassaan and Azhar, Naveen and Hameed, Abdullah and Zayed, Alaa and others},
  title   = {{Gantenerumab for Early Alzheimer's Disease: An Updated Systematic Review and Meta-Analysis}},
  journal = {Brain and behavior},
  year    = {2026},
  doi     = {10.1002/brb3.71643},
  pmid    = {42605139},
  url     = {https://doi.org/10.1002/brb3.71643}
}

@article{pascuallucas2025-41058018,
  author  = {Pascual-Lucas, M. and Lacosta, A. M. and Montañés, M. and Canudas, J. and Loscos, J. and Monleón, I. and Allué, J. A. and Sarasa, L. and others},
  title   = {{Safety, tolerability, immunogenicity, and efficacy of ABvac40 active immunotherapy against Aβ40 in patients with mild cognitive impairment or very mild Alzheimer's disease: A randomized, double-blind, placebo-controlled phase 2 study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70776},
  pmid    = {41058018},
  url     = {https://doi.org/10.1002/alz.70776}
}

@article{nong2025-40813122,
  author  = {Nong, Kailei and Jeppesen, Britta Tendal and Shi, Qingyang and Agoritsas, Thomas and Guyatt, Gordon H and White, Heath and Gao, Yiyuan and Agarwal, Arnav and others},
  title   = {{Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2025},
  doi     = {10.1136/bmj-2024-083039},
  pmid    = {40813122},
  url     = {https://doi.org/10.1136/bmj-2024-083039}
}

@article{asada2025-40302041,
  author  = {Asada, Takashi and Thanasopoulou, Angeliki and Delmar, Paul and Wojtowicz, Jakub and Smith, Janice and Yoshiyama, Yasumasa and Yokoi, Katsunori and Watanabe, Chigusa and others},
  title   = {{Japanese participant data from three gantenerumab trials in early Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70192},
  pmid    = {40302041},
  url     = {https://doi.org/10.1002/alz.70192}
}

@article{huang2024-38743015,
  author  = {Huang, Qing and Ma, Xue-Qin and Chen, Hui-Fang},
  title   = {{Lithium Exposure and Risk of Major Neurocognitive Disorders: A Systematic Review and Meta-analysis}},
  journal = {Journal of clinical psychopharmacology},
  year    = {2024},
  doi     = {10.1097/jcp.0000000000001863},
  pmid    = {38743015},
  url     = {https://doi.org/10.1097/jcp.0000000000001863}
}

@article{salloway2025-40390253,
  author  = {Salloway, S. and Pain, A. and Lee, E. and Papka, M. and Ferguson, M. B. and Wang, H. and Hu, H. and Lu, M. and others},
  title   = {{TRAILBLAZER-ALZ 4: A phase 3 trial comparing donanemab with aducanumab on amyloid plaque clearance in early, symptomatic Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70293},
  pmid    = {40390253},
  url     = {https://doi.org/10.1002/alz.70293}
}

@article{tseng2025-40189519,
  author  = {Tseng, Ping-Tao and Zeng, Bing-Yan and Hsu, Chih-Wei and Hung, Chao-Ming and Carvalho, Andre F and Stubbs, Brendon and Chen, Yen-Wen and Chen, Tien-Yu and others},
  title   = {{The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis}},
  journal = {BMC medicine},
  year    = {2025},
  doi     = {10.1186/s12916-025-04018-w},
  pmid    = {40189519},
  url     = {https://doi.org/10.1186/s12916-025-04018-w}
}

@article{vijverberg2026-41930592,
  author  = {Vijverberg, Everard G B and Scharre, Douglas W and Woodward, Michael and Catalano, Susan and Hamby, Mary E and Grundman, Michael and Morgan, Roger E and Iaci, Jennifer and others},
  title   = {{Randomized, double-blind study of zervimesine in mild to moderate Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2026},
  doi     = {10.1177/13872877261437145},
  pmid    = {41930592},
  url     = {https://doi.org/10.1177/13872877261437145}
}

@article{tariot2026-41579901,
  author  = {Tariot, Pierre N and Lopera, Francisco S and Ríos-Romenets, Silvia and Sink, Kaycee M and Giraldo-Chica, Margarita and Acosta-Baena, Natalia and Villegas, Gustavo and Espinosa, Alejandro and others},
  title   = {{Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial}},
  journal = {The Lancet. Neurology},
  year    = {2026},
  doi     = {10.1016/s1474-4422(25)00426-0},
  pmid    = {41579901},
  url     = {https://doi.org/10.1016/s1474-4422(25)00426-0}
}

@article{dantas2024-37978096,
  author  = {Dantas, J. M. and Mutarelli, A. and Navalha, D. D. P. and Dagostin, C. S. and Romeiro, P. H. C. L. and Felix, N. and Nogueira, A. and Batista, S. and others},
  title   = {{Efficacy of anti-amyloid-ß monoclonal antibody therapy in early Alzheimer's disease: a systematic review and meta-analysis}},
  journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
  year    = {2024},
  doi     = {10.1007/s10072-023-07194-w},
  pmid    = {37978096},
  url     = {https://doi.org/10.1007/s10072-023-07194-w}
}

@article{banerjee2021-34688369,
  author  = {Banerjee, Sube and High, Juliet and Stirling, Susan and Shepstone, Lee and Swart, Ann Marie and Telling, Tanya and Henderson, Catherine and Ballard, Clive and others},
  title   = {{Study of mirtazapine for agitated behaviours in dementia (SYMBAD): a randomised, double-blind, placebo-controlled trial}},
  journal = {Lancet (London, England)},
  year    = {2021},
  doi     = {10.1016/s0140-6736(21)01210-1},
  pmid    = {34688369},
  url     = {https://doi.org/10.1016/s0140-6736(21)01210-1}
}

@article{holper2026-41980907,
  author  = {Holper, Sarah and Barnham, Kevin J and Churilov, Leonid and Yates, Paul and Brodtmann, Amy and Johns, Sally and Li, Qia-Xin and Bhalala, Oneil and others},
  title   = {{A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71381},
  pmid    = {41980907},
  url     = {https://doi.org/10.1002/alz.71381}
}

@article{burns2021-34146512,
  author  = {Burns, Daniel K and Alexander, Robert C and Welsh-Bohmer, Kathleen A and Culp, Meredith and Chiang, Carl and O'Neil, Janet and Evans, Rebecca M and Harrigan, Patrick and others},
  title   = {{Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial}},
  journal = {The Lancet. Neurology},
  year    = {2021},
  doi     = {10.1016/s1474-4422(21)00043-0},
  pmid    = {34146512},
  url     = {https://doi.org/10.1016/s1474-4422(21)00043-0}
}

@article{martens2026-42478598,
  author  = {Martens, Christopher R and Decker, Kevin P and DeConne, Theodore M and Sanjana, Faria and Horvat, Fiona and Rizzi, Nicholas A and Awad, Catherine and Habash, Elizabeth and others},
  title   = {{A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71605},
  pmid    = {42478598},
  url     = {https://doi.org/10.1002/alz.71605}
}

@article{kutzsche2025-40324978,
  author  = {Kutzsche, J. and Cosma, N. C. and Kauselmann, G. and Fenski, F. and Bieniek, C. and Bujnicki, T. and Pils, M. and Bannach, O. and others},
  title   = {{Oral PRI-002 treatment in patients with MCI or mild AD: a randomized, double-blind phase 1b trial}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-59295-z},
  pmid    = {40324978},
  url     = {https://doi.org/10.1038/s41467-025-59295-z}
}

@article{macfarlane2025-39800452,
  author  = {Macfarlane, S. and Grimmer, T. and Teo, K. and O'Brien, T. J. and Woodward, M. and Grunfeld, J. and Mander, A. and Brodtmann, A. and others},
  title   = {{Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2024.100016},
  pmid    = {39800452},
  url     = {https://doi.org/10.1016/j.tjpad.2024.100016}
}

@article{menegazdealmeida2024-38879828,
  author  = {Menegaz de Almeida, A. and Leite, M. and Lopes, L. M. and Gomes Lima, P. and Siegloch Barros, M. L. and Rocha Pinheiro, S. and Í, Andrade and Viana, P. and others},
  title   = {{Gantenerumab for early Alzheimer's disease: a systematic review and meta-analysis}},
  journal = {Expert review of neurotherapeutics},
  year    = {2024},
  doi     = {10.1080/14737175.2024.2367016},
  pmid    = {38879828},
  url     = {https://doi.org/10.1080/14737175.2024.2367016}
}

@article{qiao2024-38429615,
  author  = {Qiao, Y. and Gu, J. and Yu, M. and Chi, Y. and Ma, Y.},
  title   = {{Comparative Efficacy and Safety of Monoclonal Antibodies for Cognitive Decline in Patients with Alzheimer's Disease: A Systematic Review and Network Meta-Analysis}},
  journal = {CNS drugs},
  year    = {2024},
  doi     = {10.1007/s40263-024-01067-2},
  pmid    = {38429615},
  url     = {https://doi.org/10.1007/s40263-024-01067-2}
}

@article{toda2024-39350371,
  author  = {Toda, Y. and Iwatsubo, T. and Nakamura, Y. and Matsuda, N. and Miyata, M. and Jin, M. and Chen, T. and Kuribayashi, K. and others},
  title   = {{Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer's Disease}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2024},
  doi     = {10.14283/jpad.2024.106},
  pmid    = {39350371},
  url     = {https://doi.org/10.14283/jpad.2024.106}
}

@article{herring2020-31944580,
  author  = {Herring, W Joseph and Ceesay, Paulette and Snyder, Ellen and Bliwise, Donald and Budd, Kerry and Hutzelmann, Jill and Stevens, Joanne and Lines, Christopher and others},
  title   = {{Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12035},
  pmid    = {31944580},
  url     = {https://doi.org/10.1002/alz.12035}
}

@article{mehta2017-28832937,
  author  = {Mehta, Nishila and Rodrigues, Craig and Lamba, Manpreet and Wu, Wei and Bronskill, Susan E and Herrmann, Nathan and Gill, Sudeep S and Chan, An-Wen and others},
  title   = {{Systematic Review of Sex-Specific Reporting of Data: Cholinesterase Inhibitor Example}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2017},
  doi     = {10.1111/jgs.15020},
  pmid    = {28832937},
  url     = {https://doi.org/10.1111/jgs.15020}
}

@article{perry2026-41689888,
  author  = {Perry, Richard and Kipps, Christopher and Martín, Maria Eugenia Soto and Bozzali, Marco and Logroscino, Giancarlo and Trafford, Sarah and Dhadda, Shobha and Kanekiyo, Michio and others},
  title   = {{Lecanemab for treatment of individuals with early Alzheimer's Disease (AD) who are apolipoprotein E ε4 (ApoE ε4) non-carriers or heterozygotes}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2026},
  doi     = {10.1016/j.tjpad.2026.100507},
  pmid    = {41689888},
  url     = {https://doi.org/10.1016/j.tjpad.2026.100507}
}

@article{hsu2025-40316479,
  author  = {Hsu, C. W. and Hsu, T. W. and Kao, Y. C. and Lin, Y. H. and Thompson, T. and Carvalho, A. F. and Stubbs, B. and Tseng, P. T. and others},
  title   = {{The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100195},
  pmid    = {40316479},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100195}
}

@article{bateman2025-40120616,
  author  = {Bateman, Randall J and Li, Yan and McDade, Eric M and Llibre-Guerra, Jorge J and Clifford, David B and Atri, Alireza and Mills, Susan L and Santacruz, Anna M and others},
  title   = {{Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial}},
  journal = {The Lancet. Neurology},
  year    = {2025},
  doi     = {10.1016/s1474-4422(25)00024-9},
  pmid    = {40120616},
  url     = {https://doi.org/10.1016/s1474-4422(25)00024-9}
}

@article{liang2024-38746639,
  author  = {Liang, Y. and Doré, V. and Rowe, C. C. and Krishnadas, N.},
  title   = {{Clinical Evidence for GLP-1 Receptor Agonists in Alzheimer's Disease: A Systematic Review}},
  journal = {Journal of Alzheimer's disease reports},
  year    = {2024},
  doi     = {10.3233/adr-230181},
  pmid    = {38746639},
  url     = {https://doi.org/10.3233/adr-230181}
}

@article{chen2024-38567735,
  author  = {Chen, T. and O'Gorman, J. and Castrillo-Viguera, C. and Rajagovindan, R. and Curiale, G. G. and Tian, Y. and Patel, D. and von Rosenstiel, P. and others},
  title   = {{Results from the long-term extension of PRIME: A randomized Phase 1b trial of aducanumab}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13755},
  pmid    = {38567735},
  url     = {https://doi.org/10.1002/alz.13755}
}

@article{rashad2022-36611492,
  author  = {Rashad, A. and Rasool, A. and Shaheryar, M. and Sarfraz, A. and Sarfraz, Z. and Robles-Velasco, K. and Cherrez-Ojeda, I.},
  title   = {{Donanemab for Alzheimer's Disease: A Systematic Review of Clinical Trials}},
  journal = {Healthcare (Basel, Switzerland)},
  year    = {2022},
  doi     = {10.3390/healthcare11010032},
  pmid    = {36611492},
  url     = {https://doi.org/10.3390/healthcare11010032}
}

@article{kehoe2021-34687634,
  author  = {Kehoe, Patrick Gavin and Turner, Nicholas and Howden, Beth and Jarutyte, Lina and Clegg, Shona Louise and Malone, Ian Brian and Barnes, Josephine and Nielsen, Casper and others},
  title   = {{Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial}},
  journal = {The Lancet. Neurology},
  year    = {2021},
  doi     = {10.1016/s1474-4422(21)00263-5},
  pmid    = {34687634},
  url     = {https://doi.org/10.1016/s1474-4422(21)00263-5}
}

@article{salloway2021-34155411,
  author  = {Salloway, S. and Farlow, M. and McDade, E. and Clifford, D. B. and Wang, G. and Llibre-Guerra, J. J. and Hitchcock, J. M. and Mills, S. L. and others},
  title   = {{A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2021},
  doi     = {10.1038/s41591-021-01369-8},
  pmid    = {34155411},
  url     = {https://doi.org/10.1038/s41591-021-01369-8}
}

@article{biessels2019-31399442,
  author  = {Biessels, G. J. and Verhagen, C. and Janssen, J. and van den Berg, E. and Zinman, B. and Rosenstock, J. and George, J. T. and Passera, A. and others},
  title   = {{Effect of Linagliptin on Cognitive Performance in Patients With Type 2 Diabetes and Cardiorenal Comorbidities: The CARMELINA Randomized Trial}},
  journal = {Diabetes care},
  year    = {2019},
  doi     = {10.2337/dc19-0783},
  pmid    = {31399442},
  url     = {https://doi.org/10.2337/dc19-0783}
}

@article{matsunaga2015-25860130,
  author  = {Matsunaga, S. and Kishi, T. and Iwata, N.},
  title   = {{Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis}},
  journal = {PloS one},
  year    = {2015},
  doi     = {10.1371/journal.pone.0123289},
  pmid    = {25860130},
  url     = {https://doi.org/10.1371/journal.pone.0123289}
}

@article{burns2025-40566796,
  author  = {Burns, Jeffrey M and Morris, Jill K and Vidoni, Eric D and Wilkins, Heather M and Choi, In-Young and Lee, Phil and Hunt, Suzanne L and Mahnken, Jonathan D and others},
  title   = {{Effects of the SGLT2 inhibitor dapagliflozin in early Alzheimer's disease: A randomized controlled trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70416},
  pmid    = {40566796},
  url     = {https://doi.org/10.1002/alz.70416}
}

@article{terao2025-40386876,
  author  = {Terao, Itsuki and Kodama, Wakako},
  title   = {{Comparative efficacy, tolerability, and acceptability of aducanumab, lecanemab, and donanemab with repetitive transcranial magnetic stimulation on cognitive function in mild cognitive impairment and Alzheimer's disease: A systematic review and network meta-analysis}},
  journal = {Journal of psychopharmacology (Oxford, England)},
  year    = {2025},
  doi     = {10.1177/02698811251340901},
  pmid    = {40386876},
  url     = {https://doi.org/10.1177/02698811251340901}
}

@article{deng2024-39312316,
  author  = {Deng, Xiaoyan and Li, Daishun},
  title   = {{Effect of long-term pharmacological treatments on Alzheimer disease: A systematic review and network meta-analysis}},
  journal = {Medicine},
  year    = {2024},
  doi     = {10.1097/md.0000000000039753},
  pmid    = {39312316},
  url     = {https://doi.org/10.1097/md.0000000000039753}
}

@article{terao2024-38253184,
  author  = {Terao, Itsuki and Kodama, Wakako},
  title   = {{Comparative efficacy, tolerability and acceptability of donanemab, lecanemab, aducanumab and lithium on cognitive function in mild cognitive impairment and Alzheimer's disease: A systematic review and network meta-analysis}},
  journal = {Ageing research reviews},
  year    = {2024},
  doi     = {10.1016/j.arr.2024.102203},
  pmid    = {38253184},
  url     = {https://doi.org/10.1016/j.arr.2024.102203}
}

@article{costa2022-34942135,
  author  = {Costa, Alberto C S and Brandão, Ana C and Boada, Richard and Barrionuevo, Veridiana L and Taylor, Hudson G and Roth, Elizabeth and Stasko, Melissa R and Johnson, Mark W and others},
  title   = {{Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial}},
  journal = {The Lancet. Neurology},
  year    = {2022},
  doi     = {10.1016/s1474-4422(21)00369-0},
  pmid    = {34942135},
  url     = {https://doi.org/10.1016/s1474-4422(21)00369-0}
}

@article{hannestad2021-33967047,
  author  = {Hannestad, Jonas and Duclos, Tiffanie and Chao, Whitney and Koborsi, Katie and Klutzaritz, Vicki and Beck, Brian and Patel, Ashok K and Scott, James and others},
  title   = {{Safety and Tolerability of GRF6019 Infusions in Severe Alzheimer's Disease: A Phase II Double-Blind Placebo-Controlled Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210011},
  pmid    = {33967047},
  url     = {https://doi.org/10.3233/jad-210011}
}

@article{winblad2008-18322263,
  author  = {Winblad, B. and Gauthier, S. and Scinto, L. and Feldman, H. and Wilcock, G. K. and Truyen, L. and Mayorga, A. J. and Wang, D. and others},
  title   = {{Safety and efficacy of galantamine in subjects with mild cognitive impairment}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000303815.69777.26},
  pmid    = {18322263},
  url     = {https://doi.org/10.1212/01.wnl.0000303815.69777.26}
}

@article{shim2026-41352683,
  author  = {Shim, G. H. and Lau, E. C. Y. and Huynh, A. L. H. and Lu, C. Y. and Tan, E. C. K.},
  title   = {{Influence of patient characteristics on efficacy and safety of anti-amyloid monoclonal antibodies in Alzheimer's disease: A systematic review and meta-analysis}},
  journal = {Ageing research reviews},
  year    = {2026},
  doi     = {10.1016/j.arr.2025.102981},
  pmid    = {41352683},
  url     = {https://doi.org/10.1016/j.arr.2025.102981}
}

@article{greeley2025-40912996,
  author  = {Greeley, David and Nash, Marshall and Herskowitz, Brad and Kim, Fred and Rock, James and Prins, Neils and Kim, SangYun and Xi, Tianyang and others},
  title   = {{A phase 2 randomized, placebo-controlled study on the efficacy and safety of AR1001, a phosphodiesterase-5 inhibitor, in patients with mild-to-moderate Alzheimer's disease}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100337},
  pmid    = {40912996},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100337}
}

@article{wu2023-38017568,
  author  = {Wu, W. and Ji, Y. and Wang, Z. and Wu, X. and Li, J. and Gu, F. and Chen, Z.},
  title   = {{The FDA-approved anti-amyloid-β monoclonal antibodies for the treatment of Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials}},
  journal = {European journal of medical research},
  year    = {2023},
  doi     = {10.1186/s40001-023-01512-w},
  pmid    = {38017568},
  url     = {https://doi.org/10.1186/s40001-023-01512-w}
}

@article{penninkilampi2017-28025724,
  author  = {Penninkilampi, R. and Brothers, H. M. and Eslick, G. D.},
  title   = {{Safety and Efficacy of Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: A Systematic Review and Meta-Analysis}},
  journal = {Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology},
  year    = {2017},
  doi     = {10.1007/s11481-016-9722-5},
  pmid    = {28025724},
  url     = {https://doi.org/10.1007/s11481-016-9722-5}
}

@article{winblad2001-11502918,
  author  = {Winblad, B. and Engedal, K. and Soininen, H. and Verhey, F. and Waldemar, G. and Wimo, A. and Wetterholm, A. L. and Zhang, R. and others},
  title   = {{A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD}},
  journal = {Neurology},
  year    = {2001},
  doi     = {10.1212/wnl.57.3.489},
  pmid    = {11502918},
  url     = {https://doi.org/10.1212/wnl.57.3.489}
}

@article{chowdhury2023-37902139,
  author  = {Chowdhury, Selia and Chowdhury, Nurjahan Shipa},
  title   = {{Novel anti-amyloid-beta (Aβ) monoclonal antibody lecanemab for Alzheimer's disease: A systematic review}},
  journal = {International journal of immunopathology and pharmacology},
  year    = {2023},
  doi     = {10.1177/03946320231209839},
  pmid    = {37902139},
  url     = {https://doi.org/10.1177/03946320231209839}
}

@article{mallinckrodt2023-36946443,
  author  = {Mallinckrodt, C and Tian, Y and Aisen, P S and Barkhof, F and Cohen, S and Dent, G and Hansson, O and Harrison, K and others},
  title   = {{Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2023},
  doi     = {10.14283/jpad.2023.6},
  pmid    = {36946443},
  url     = {https://doi.org/10.14283/jpad.2023.6}
}

@article{devanand2022-34059401,
  author  = {Devanand, D P and Crocco, Elizabeth and Forester, Brent P and Husain, Mustafa M and Lee, Seonjoo and Vahia, Ipsit V and Andrews, Howard and Simon-Pearson, Laura and others},
  title   = {{Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease: Lit-AD Randomized Clinical Trial}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2022},
  doi     = {10.1016/j.jagp.2021.04.014},
  pmid    = {34059401},
  url     = {https://doi.org/10.1016/j.jagp.2021.04.014}
}

@article{rosenbloom2021-33719017,
  author  = {Rosenbloom, Michael and Barclay, Terry R and Kashyap, Bhavani and Hage, Lyndsay and O'Keefe, Lauren R and Svitak, Aleta and Pyle, Maria and Frey, William and others},
  title   = {{A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease}},
  journal = {Drugs \& aging},
  year    = {2021},
  doi     = {10.1007/s40266-021-00845-7},
  pmid    = {33719017},
  url     = {https://doi.org/10.1007/s40266-021-00845-7}
}

@article{lowe2021-34585215,
  author  = {Lowe, S L and Evans, C Duggan and Shcherbinin, S and Cheng, Y-J and Willis, B A and Gueorguieva, I and Lo, A C and Fleisher, A S and others},
  title   = {{Donanemab (LY3002813) Phase 1b Study in Alzheimer's Disease: Rapid and Sustained Reduction of Brain Amyloid Measured by Florbetapir F18 Imaging}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2021},
  doi     = {10.14283/jpad.2021.56},
  pmid    = {34585215},
  url     = {https://doi.org/10.14283/jpad.2021.56}
}

@article{wilkinson2014-25297016,
  author  = {Wilkinson, David and Windfeld, Kristian and Colding-Jørgensen, Eskild},
  title   = {{Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial}},
  journal = {The Lancet. Neurology},
  year    = {2014},
  doi     = {10.1016/s1474-4422(14)70198-x},
  pmid    = {25297016},
  url     = {https://doi.org/10.1016/s1474-4422(14)70198-x}
}

@article{choudhury2026-41862354,
  author  = {Choudhury, Ishraq and Ward, John Headly and Mahesh, Sahana and Alam, Uazman and Azmi, Shazli and Anson, Matthew},
  title   = {{Effect of Glucagon-Like-Peptide-1 Receptor Agonists (GLP-1 RA) on Neuropsychiatric Outcomes: A Systematic Review and Meta-Analysis}},
  journal = {Clinical therapeutics},
  year    = {2026},
  doi     = {10.1016/j.clinthera.2026.02.010},
  pmid    = {41862354},
  url     = {https://doi.org/10.1016/j.clinthera.2026.02.010}
}

@article{cury2025-41160460,
  author  = {Cury, Rafael de Morais and da Silva, Taynara and Cezar-Dos-Santos, Fernando and Fakih, Yasmin Rafaela Correia and Narvaez, Karlin Andrea Ramírez and Gouvea, Murilo Chaves and Espínola, Carlos and Ferreira, Charles Francisco and others},
  title   = {{A randomized clinical trial of low-dose cannabis extract in Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877251389608},
  pmid    = {41160460},
  url     = {https://doi.org/10.1177/13872877251389608}
}

@article{pereiradasilva2025-40692324,
  author  = {Pereira da Silva, A. M. and Falcão, L. and Virgilio, F. and Rodrigues Menezes, I. and Leite, M. and Farias, E. and Nascimento, M. and Lee Han, M. and others},
  title   = {{Efficacy and APOE ε4-stratified risk of donanemab in Alzheimer's disease: A systematic review and meta-analysis of randomized clinical trials}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877251361044},
  pmid    = {40692324},
  url     = {https://doi.org/10.1177/13872877251361044}
}

@article{cas2024-38565814,
  author  = {Cas, A Dei and Micheli, M M and Aldigeri, R and Gardini, S and Ferrari-Pellegrini, F and Perini, M and Messa, G and Antonini, M and others},
  title   = {{Long-acting exenatide does not prevent cognitive decline in mild cognitive impairment: a proof-of-concept clinical trial}},
  journal = {Journal of endocrinological investigation},
  year    = {2024},
  doi     = {10.1007/s40618-024-02320-7},
  pmid    = {38565814},
  url     = {https://doi.org/10.1007/s40618-024-02320-7}
}

@article{orr2024-37994989,
  author  = {Orr, Miranda E and Kotkowski, Eithan and Ramirez, Paulino and Bair-Kelps, Darcy and Liu, Qianqian and Brenner, Charles and Schmidt, Mark S and Fox, Peter T and others},
  title   = {{A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment}},
  journal = {GeroScience},
  year    = {2024},
  doi     = {10.1007/s11357-023-00999-9},
  pmid    = {37994989},
  url     = {https://doi.org/10.1007/s11357-023-00999-9}
}

@article{sperling2023-37458272,
  author  = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Rafii, M. S. and Johnson, K. and Masters, C. L. and van Dyck, C. H. and Iwatsubo, T. and others},
  title   = {{Trial of Solanezumab in Preclinical Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {2023},
  doi     = {10.1056/nejmoa2305032},
  pmid    = {37458272},
  url     = {https://doi.org/10.1056/nejmoa2305032}
}

@article{jeremic2023-37423541,
  author  = {Jeremic, D. and Navarro-López, J. D. and Jiménez-Díaz, L.},
  title   = {{Efficacy and safety of anti-amyloid-β monoclonal antibodies in current Alzheimer's disease phase III clinical trials: A systematic review and interactive web app-based meta-analysis}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2023.102012},
  pmid    = {37423541},
  url     = {https://doi.org/10.1016/j.arr.2023.102012}
}

@article{tang2023-36821780,
  author  = {Tang, H. and Shao, H. and Shaaban, C. E. and Yang, K. and Brown, J. and Anton, S. and Wu, Y. and Bress, A. and others},
  title   = {{Newer glucose-lowering drugs and risk of dementia: A systematic review and meta-analysis of observational studies}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2023},
  doi     = {10.1111/jgs.18306},
  pmid    = {36821780},
  url     = {https://doi.org/10.1111/jgs.18306}
}

@article{sauder2022-36414626,
  author  = {Sauder, Colin and Allen, Luke A and Baker, Elizabeth and Miller, Andrew C and Paul, Steven M and Brannan, Stephen K},
  title   = {{Effectiveness of KarXT (xanomeline-trospium) for cognitive impairment in schizophrenia: post hoc analyses from a randomised, double-blind, placebo-controlled phase 2 study}},
  journal = {Translational psychiatry},
  year    = {2022},
  doi     = {10.1038/s41398-022-02254-9},
  pmid    = {36414626},
  url     = {https://doi.org/10.1038/s41398-022-02254-9}
}

@article{takada2022-35932158,
  author  = {Takada, Michihiro and Tanaka, Shin and Tanaka, Koh and Tsukie, Tamao and Tsukamoto-Yasui, Masako and Suzuki, Katsuya and Noguchi, Yasushi and Imaizumi, Akira and others},
  title   = {{Effects of an essential amino acid mixture on behavioral and psychological symptoms of dementia and executive function in patients with Alzheimer's disease: A double-blind, randomized, placebo-controlled exploratory clinical trial}},
  journal = {International journal of geriatric psychiatry},
  year    = {2022},
  doi     = {10.1002/gps.5782},
  pmid    = {35932158},
  url     = {https://doi.org/10.1002/gps.5782}
}

@article{watts2023-35109724,
  author  = {Watts, Katrina E and Storr, Nicholas J and Barr, Phoebe G and Rajkumar, Anto P},
  title   = {{Systematic review of pharmacological interventions for people with Lewy body dementia}},
  journal = {Aging \& mental health},
  year    = {2023},
  doi     = {10.1080/13607863.2022.2032601},
  pmid    = {35109724},
  url     = {https://doi.org/10.1080/13607863.2022.2032601}
}

@article{hua2022-35180125,
  author  = {Hua, Xue and Church, Kevin and Walker, William and L'Hostis, Philippe and Viardot, Geoffrey and Danjou, Philippe and Hendrix, Suzanne and Moebius, Hans J},
  title   = {{Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer's Disease: Randomized, Placebo-Controlled, Double-Blind, Phase I Clinical Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-215511},
  pmid    = {35180125},
  url     = {https://doi.org/10.3233/jad-215511}
}

@article{fang2021-35572351,
  author  = {Fang, J. and Zhang, P. and Zhou, Y. and Chiang, C. W. and Tan, J. and Hou, Y. and Stauffer, S. and Li, L. and others},
  title   = {{Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease}},
  journal = {Nature aging},
  year    = {2021},
  doi     = {10.1038/s43587-021-00138-z},
  pmid    = {35572351},
  url     = {https://doi.org/10.1038/s43587-021-00138-z}
}

@article{mcneil2018-30221595,
  author  = {McNeil, J. J. and Nelson, M. R. and Woods, R. L. and Lockery, J. E. and Wolfe, R. and Reid, C. M. and Kirpach, B. and Shah, R. C. and others},
  title   = {{Effect of Aspirin on All-Cause Mortality in the Healthy Elderly}},
  journal = {The New England journal of medicine},
  year    = {2018},
  doi     = {10.1056/nejmoa1803955},
  pmid    = {30221595},
  url     = {https://doi.org/10.1056/nejmoa1803955}
}

@article{nave2017-28550255,
  author  = {Nave, Stephane and Doody, Rachelle S and Boada, Mercè and Grimmer, Timo and Savola, Juha-Matti and Delmar, Paul and Pauly-Evers, Meike and Nikolcheva, Tania and others},
  title   = {{Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD)}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-161309},
  pmid    = {28550255},
  url     = {https://doi.org/10.3233/jad-161309}
}

@article{gauthier2016-27863809,
  author  = {Gauthier, S. and Feldman, H. H. and Schneider, L. S. and Wilcock, G. K. and Frisoni, G. B. and Hardlund, J. H. and Moebius, H. J. and others},
  title   = {{Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial}},
  journal = {Lancet (London, England)},
  year    = {2016},
  doi     = {10.1016/s0140-6736(16)31275-2},
  pmid    = {27863809},
  url     = {https://doi.org/10.1016/s0140-6736(16)31275-2}
}

@article{study2014-24928805,
  author  = {{PD Med Collaborative Group} and Gray, R. and Ives, N. and Rick, C. and Patel, S. and Gray, A. and Jenkinson, C. and McIntosh, E. and others},
  title   = {{Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial}},
  journal = {Lancet (London, England)},
  year    = {2014},
  doi     = {10.1016/s0140-6736(14)60683-8},
  pmid    = {24928805},
  url     = {https://doi.org/10.1016/s0140-6736(14)60683-8}
}

@article{hegarty1994-8092334,
  author  = {Hegarty, J. D. and Baldessarini, R. J. and Tohen, M. and Waternaux, C. and Oepen, G.},
  title   = {{One hundred years of schizophrenia: a meta-analysis of the outcome literature}},
  journal = {The American journal of psychiatry},
  year    = {1994},
  doi     = {10.1176/ajp.151.10.1409},
  pmid    = {8092334},
  url     = {https://doi.org/10.1176/ajp.151.10.1409}
}

@article{knapp1994-8139083,
  author  = {Knapp, M. J. and Knopman, D. S. and Solomon, P. R. and Pendlebury, W. W. and Davis, C. S. and Gracon, S. I.},
  title   = {{A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group}},
  journal = {JAMA},
  year    = {1994},
  doi     = {10.1001/jama.1994.03510370037029},
  pmid    = {8139083},
  url     = {https://doi.org/10.1001/jama.1994.03510370037029}
}

@article{kuatedefo2024-37869901,
  author  = {Kuate Defo, A. and Bakula, V. and Pisaturo, A. and Labos, C. and Wing, S. S. and Daskalopoulou, S. S.},
  title   = {{Diabetes, antidiabetic medications and risk of dementia: A systematic umbrella review and meta-analysis}},
  journal = {Diabetes, obesity \& metabolism},
  year    = {2024},
  doi     = {10.1111/dom.15331},
  pmid    = {37869901},
  url     = {https://doi.org/10.1111/dom.15331}
}

@article{koh2021-33771205,
  author  = {Koh, Seong-Ho and Kwon, Hyuk Sung and Choi, Seong Hye and Jeong, Jee Hyang and Na, Hae Ri and Lee, Chan Nyoung and Yang, YoungSoon and Lee, Ae Young and others},
  title   = {{Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer's disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00803-w},
  pmid    = {33771205},
  url     = {https://doi.org/10.1186/s13195-021-00803-w}
}

@article{wang2020-32928279,
  author  = {Wang, Tao and Kuang, Weihong and Chen, Wei and Xu, Wenwei and Zhang, Liming and Li, Yingjie and Li, Hailin and Peng, Ying and others},
  title   = {{A phase II randomized trial of sodium oligomannate in Alzheimer's dementia}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00678-3},
  pmid    = {32928279},
  url     = {https://doi.org/10.1186/s13195-020-00678-3}
}

@article{zhou2020-32446679,
  author  = {Zhou, J. B. and Tang, X. and Han, M. and Yang, J. and Simó, R.},
  title   = {{Impact of antidiabetic agents on dementia risk: A Bayesian network meta-analysis}},
  journal = {Metabolism: clinical and experimental},
  year    = {2020},
  doi     = {10.1016/j.metabol.2020.154265},
  pmid    = {32446679},
  url     = {https://doi.org/10.1016/j.metabol.2020.154265}
}

@article{yasar2013-23911756,
  author  = {Yasar, S. and Xia, J. and Yao, W. and Furberg, C. D. and Xue, Q. L. and Mercado, C. I. and Fitzpatrick, A. L. and Fried, L. P. and others},
  title   = {{Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study}},
  journal = {Neurology},
  year    = {2013},
  doi     = {10.1212/wnl.0b013e3182a35228},
  pmid    = {23911756},
  url     = {https://doi.org/10.1212/wnl.0b013e3182a35228}
}

@article{yurkomauro2010-20434961,
  author  = {Yurko-Mauro, K. and McCarthy, D. and Rom, D. and Nelson, E. B. and Ryan, A. S. and Blackwell, A. and Salem, N. and Stedman, M. and others},
  title   = {{Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2010},
  doi     = {10.1016/j.jalz.2010.01.013},
  pmid    = {20434961},
  url     = {https://doi.org/10.1016/j.jalz.2010.01.013}
}

@article{ballard2009-19138567,
  author  = {Ballard, C. and Hanney, M. L. and Theodoulou, M. and Douglas, S. and McShane, R. and Kossakowski, K. and Gill, R. and Juszczak, E. and others},
  title   = {{The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial}},
  journal = {The Lancet. Neurology},
  year    = {2009},
  doi     = {10.1016/s1474-4422(08)70295-3},
  pmid    = {19138567},
  url     = {https://doi.org/10.1016/s1474-4422(08)70295-3}
}

@article{kavirajan2007-17689146,
  author  = {Kavirajan, H. and Schneider, L. S.},
  title   = {{Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials}},
  journal = {The Lancet. Neurology},
  year    = {2007},
  doi     = {10.1016/s1474-4422(07)70195-3},
  pmid    = {17689146},
  url     = {https://doi.org/10.1016/s1474-4422(07)70195-3}
}

@article{bullock2005-16083542,
  author  = {Bullock, Roger and Touchon, Jacques and Bergman, Howard and Gambina, Giuseppe and He, Yunsheng and Rapatz, Günter and Nagel, Jennifer and Lane, Roger},
  title   = {{Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period}},
  journal = {Current medical research and opinion},
  year    = {2005},
  doi     = {10.1185/030079905x56565},
  pmid    = {16083542},
  url     = {https://doi.org/10.1185/030079905x56565}
}

@article{gill2004-15604527,
  author  = {Gill, S. S. and Bronskill, S. E. and Mamdani, M. and Sykora, K. and Li, P. and Shulman, K. I. and Anderson, G. M. and Hillmer, M. P. and others},
  title   = {{Representation of patients with dementia in clinical trials of donepezil}},
  journal = {The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique},
  year    = {2004},
  pmid    = {15604527}
}

@article{teri2000-11087767,
  author  = {Teri, L. and Logsdon, R. G. and Peskind, E. and Raskind, M. and Weiner, M. F. and Tractenberg, R. E. and Foster, N. L. and Schneider, L. S. and others},
  title   = {{Treatment of agitation in AD: a randomized, placebo-controlled clinical trial}},
  journal = {Neurology},
  year    = {2000},
  doi     = {10.1212/wnl.55.9.1271},
  pmid    = {11087767},
  url     = {https://doi.org/10.1212/wnl.55.9.1271}
}

@article{degiorgi2024-39764175,
  author  = {De Giorgi, Riccardo and Koychev, Ivan and Adler, Amanda I and Cowen, Philip J and Harmer, Catherine J and Harrison, Paul J and Taquet, Maxime},
  title   = {{12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes: a propensity-score matched cohort study}},
  journal = {EClinicalMedicine},
  year    = {2024},
  doi     = {10.1016/j.eclinm.2024.102726},
  pmid    = {39764175},
  url     = {https://doi.org/10.1016/j.eclinm.2024.102726}
}

@article{lu2024-38657568,
  author  = {Lu, Qiuying and Lv, Huijing and Liu, Xiaotong and Zang, Lili and Zhang, Yue and Meng, Qinghui},
  title   = {{Lithium Therapy's Potential to Lower Dementia Risk and the Prevalence of Alzheimer's Disease: A Meta-Analysis}},
  journal = {European neurology},
  year    = {2024},
  doi     = {10.1159/000538846},
  pmid    = {38657568},
  url     = {https://doi.org/10.1159/000538846}
}

@article{neve2024-39177596,
  author  = {Neve, A. and Das, B. and Wojtowicz, J. and Huang, Z. and Bullain, S. and Watkin, M. and Lott, D. and Bittner, T. and others},
  title   = {{Long-Term Safety of Gantenerumab in Participants with Alzheimer's Disease: A Phase III, Double-Blind, and Open-Label Extension Study (Marguerite RoAD)}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-240221},
  pmid    = {39177596},
  url     = {https://doi.org/10.3233/jad-240221}
}

@article{boess2024-38706270,
  author  = {Boess, F G and Scelsi, M A and Grimmer, T and Perry, R J and Tonietto, M and Klein, G and Hofmann, C and Salami, M and others},
  title   = {{At-Home Administration of Gantenerumab by Care Partners to People with Early Alzheimer's Disease: Feasibility, Safety and Pharmacodynamic Impact}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2024},
  doi     = {10.14283/jpad.2024.60},
  pmid    = {38706270},
  url     = {https://doi.org/10.14283/jpad.2024.60}
}

@article{gwizdala2021-33856613,
  author  = {Gwizdala, Kathryn L and Ferguson, David P and Kovan, Jeffery and Novak, Vera and Pontifex, Matthew B},
  title   = {{Placebo controlled phase II clinical trial: Safety and efficacy of combining intranasal insulin \& acute exercise}},
  journal = {Metabolic brain disease},
  year    = {2021},
  doi     = {10.1007/s11011-021-00727-2},
  pmid    = {33856613},
  url     = {https://doi.org/10.1007/s11011-021-00727-2}
}

@article{zhou2021-33614900,
  author  = {Zhou, Bo and Zissimopoulos, Julie and Nadeem, Hasan and Crane, Matthew A and Goldman, Dana and Romley, John A},
  title   = {{Association between exenatide use and incidence of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12139},
  pmid    = {33614900},
  url     = {https://doi.org/10.1002/trc2.12139}
}

@article{salloway2018-30129411,
  author  = {Salloway, S. and Marshall, G. A. and Lu, M. and Brashear, H. R.},
  title   = {{Long-Term Safety and Efficacy of Bapineuzumab in Patients with Mild-to-Moderate Alzheimer's Disease: A Phase 2, Open-Label Extension Study}},
  journal = {Current Alzheimer research},
  year    = {2018},
  doi     = {10.2174/1567205015666180821114813},
  pmid    = {30129411},
  url     = {https://doi.org/10.2174/1567205015666180821114813}
}

@article{nordberg2009-19199870,
  author  = {Nordberg, Agneta and Darreh-Shori, Taher and Peskind, Elaine and Soininen, Hilkka and Mousavi, Malahat and Eagle, Gina and Lane, Roger},
  title   = {{Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients}},
  journal = {Current Alzheimer research},
  year    = {2009},
  doi     = {10.2174/156720509787313961},
  pmid    = {19199870},
  url     = {https://doi.org/10.2174/156720509787313961}
}

@article{wesnes2005-16301500,
  author  = {Wesnes, K. A. and McKeith, I. and Edgar, C. and Emre, M. and Lane, R.},
  title   = {{Benefits of rivastigmine on attention in dementia associated with Parkinson disease}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000184517.69816.e9},
  pmid    = {16301500},
  url     = {https://doi.org/10.1212/01.wnl.0000184517.69816.e9}
}

@article{holmes2004-15277611,
  author  = {Holmes, C. and Wilkinson, D. and Dean, C. and Vethanayagam, S. and Olivieri, S. and Langley, A. and Pandita-Gunawardena, N. D. and Hogg, F. and others},
  title   = {{The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000129990.32253.7b},
  pmid    = {15277611},
  url     = {https://doi.org/10.1212/01.wnl.0000129990.32253.7b}
}

@article{wilkinson2001-11571763,
  author  = {Wilkinson, D and Murray, J},
  title   = {{Galantamine: a randomized, double-blind, dose comparison in patients with Alzheimer's disease}},
  journal = {International journal of geriatric psychiatry},
  year    = {2001},
  doi     = {10.1002/gps.409},
  pmid    = {11571763},
  url     = {https://doi.org/10.1002/gps.409}
}

@article{aisen2000-10680787,
  author  = {Aisen, P. S. and Davis, K. L. and Berg, J. D. and Schafer, K. and Campbell, K. and Thomas, R. G. and Weiner, M. F. and Farlow, M. R. and others},
  title   = {{A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study}},
  journal = {Neurology},
  year    = {2000},
  doi     = {10.1212/wnl.54.3.588},
  pmid    = {10680787},
  url     = {https://doi.org/10.1212/wnl.54.3.588}
}

@article{hossain2024-38867460,
  author  = {Hossain, M. F. and Husna, A. U. and Kharel, M.},
  title   = {{Use of lecanemab for the treatment of Alzheimer's disease: A systematic review}},
  journal = {Brain and behavior},
  year    = {2024},
  doi     = {10.1002/brb3.3592},
  pmid    = {38867460},
  url     = {https://doi.org/10.1002/brb3.3592}
}

@article{qiao2023-37213538,
  author  = {Qiao, Y. and Chi, Y. and Zhang, Q. and Ma, Y.},
  title   = {{Safety and efficacy of lecanemab for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials}},
  journal = {Frontiers in aging neuroscience},
  year    = {2023},
  doi     = {10.3389/fnagi.2023.1169499},
  pmid    = {37213538},
  url     = {https://doi.org/10.3389/fnagi.2023.1169499}
}

@article{torrandellharo2020-33283039,
  author  = {Torrandell-Haro, G. and Branigan, G. L. and Vitali, F. and Geifman, N. and Zissimopoulos, J. M. and Brinton, R. D.},
  title   = {{Statin therapy and risk of Alzheimer's and age-related neurodegenerative diseases}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2020},
  doi     = {10.1002/trc2.12108},
  pmid    = {33283039},
  url     = {https://doi.org/10.1002/trc2.12108}
}

@article{yu2020-32690803,
  author  = {Yu, J. T. and Xu, W. and Tan, C. C. and Andrieu, S. and Suckling, J. and Evangelou, E. and Pan, A. and Zhang, C. and others},
  title   = {{Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2020},
  doi     = {10.1136/jnnp-2019-321913},
  pmid    = {32690803},
  url     = {https://doi.org/10.1136/jnnp-2019-321913}
}

@article{cao2018-29790638,
  author  = {Cao, B. and Rosenblat, J. D. and Brietzke, E. and Park, C. and Lee, Y. and Musial, N. and Pan, Z. and Mansur, R. B. and others},
  title   = {{Comparative efficacy and acceptability of antidiabetic agents for Alzheimer's disease and mild cognitive impairment: A systematic review and network meta-analysis}},
  journal = {Diabetes, obesity \& metabolism},
  year    = {2018},
  doi     = {10.1111/dom.13373},
  pmid    = {29790638},
  url     = {https://doi.org/10.1111/dom.13373}
}

@article{relkin2017-28381506,
  author  = {Relkin, Norman R and Thomas, Ronald G and Rissman, Robert A and Brewer, James B and Rafii, Michael S and van Dyck, Christopher H and Jack, Clifford R and Sano, Mary and others},
  title   = {{A phase 3 trial of IV immunoglobulin for Alzheimer disease}},
  journal = {Neurology},
  year    = {2017},
  doi     = {10.1212/wnl.0000000000003904},
  pmid    = {28381506},
  url     = {https://doi.org/10.1212/wnl.0000000000003904}
}

@article{kishi2017-28922160,
  author  = {Kishi, T. and Matsunaga, S. and Oya, K. and Nomura, I. and Ikuta, T. and Iwata, N.},
  title   = {{Memantine for Alzheimer's Disease: An Updated Systematic Review and Meta-analysis}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-170424},
  pmid    = {28922160},
  url     = {https://doi.org/10.3233/jad-170424}
}

@article{abushakra2017-29182706,
  author  = {Abushakra, S and Porsteinsson, A and Scheltens, P and Sadowsky, C and Vellas, B and Cummings, J and Gauthier, S and Hey, J A and others},
  title   = {{Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2017},
  doi     = {10.14283/jpad.2017.26},
  pmid    = {29182706},
  url     = {https://doi.org/10.14283/jpad.2017.26}
}

@article{furukawa2017-26711658,
  author  = {Furukawa, Katsutoshi and Tomita, Naoki and Uematsu, Daisuke and Okahara, Kazunori and Shimada, Hiroyuki and Ikeda, Masaki and Matsui, Toshifumi and Kozaki, Koichi and others},
  title   = {{Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease}},
  journal = {Geriatrics \& gerontology international},
  year    = {2017},
  doi     = {10.1111/ggi.12696},
  pmid    = {26711658},
  url     = {https://doi.org/10.1111/ggi.12696}
}

@article{mamikonyan2015-25914281,
  author  = {Mamikonyan, E. and Xie, S. X. and Melvin, E. and Weintraub, D.},
  title   = {{Rivastigmine for mild cognitive impairment in Parkinson disease: a placebo-controlled study}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2015},
  doi     = {10.1002/mds.26236},
  pmid    = {25914281},
  url     = {https://doi.org/10.1002/mds.26236}
}

@article{ott2015-25575908,
  author  = {Ott, B. R. and Daiello, L. A. and Dahabreh, I. J. and Springate, B. A. and Bixby, K. and Murali, M. and Trikalinos, T. A.},
  title   = {{Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials}},
  journal = {Journal of general internal medicine},
  year    = {2015},
  doi     = {10.1007/s11606-014-3115-3},
  pmid    = {25575908},
  url     = {https://doi.org/10.1007/s11606-014-3115-3}
}

@article{swiger2013-24095248,
  author  = {Swiger, K. J. and Manalac, R. J. and Blumenthal, R. S. and Blaha, M. J. and Martin, S. S.},
  title   = {{Statins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects}},
  journal = {Mayo Clinic proceedings},
  year    = {2013},
  doi     = {10.1016/j.mayocp.2013.07.013},
  pmid    = {24095248},
  url     = {https://doi.org/10.1016/j.mayocp.2013.07.013}
}

@article{farlow2012-22672770,
  author  = {Farlow, M. and Arnold, S. E. and van Dyck, C. H. and Aisen, P. S. and Snider, B. J. and Porsteinsson, A. P. and Friedrich, S. and Dean, R. A. and others},
  title   = {{Safety and biomarker effects of solanezumab in patients with Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2012},
  doi     = {10.1016/j.jalz.2011.09.224},
  pmid    = {22672770},
  url     = {https://doi.org/10.1016/j.jalz.2011.09.224}
}

@article{hart2007-17938402,
  author  = {Hart, Robert G. and Pearce, Lesly A. and Aguilar, Maria I.},
  title   = {{Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial Fibrillation}},
  journal = {Annals of Internal Medicine},
  year    = {2007},
  doi     = {10.7326/0003-4819-147-8-200710160-00018},
  pmid    = {17938402},
  url     = {https://doi.org/10.7326/0003-4819-147-8-200710160-00018}
}

@article{trinh2003-12517232,
  author  = {Trinh, N. H. and Hoblyn, J. and Mohanty, S. and Yaffe, K.},
  title   = {{Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis}},
  journal = {JAMA},
  year    = {2003},
  doi     = {10.1001/jama.289.2.210},
  pmid    = {12517232},
  url     = {https://doi.org/10.1001/jama.289.2.210}
}

@article{simons2002-12205648,
  author  = {Simons, M. and Schwärzler, F. and Lütjohann, D. and von Bergmann, K. and Beyreuther, K. and Dichgans, J. and Wormstall, H. and Hartmann, T. and others},
  title   = {{Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial}},
  journal = {Annals of neurology},
  year    = {2002},
  doi     = {10.1002/ana.10292},
  pmid    = {12205648},
  url     = {https://doi.org/10.1002/ana.10292}
}

@article{raket2026-42273802,
  author  = {Raket, Lars L and Lu, Ming and Evans, Cynthia D and Zimmer, Jennifer A and Sparks, JonDavid and Collins, Emily C and Shcherbinin, Sergey and Wang, Hong and others},
  title   = {{Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71577},
  pmid    = {42273802},
  url     = {https://doi.org/10.1002/alz.71577}
}

@article{wang2024-39446320,
  author  = {Wang, Jingya and Antza, Christina and Lee, Wen Hwa and Coker, Jesse and Keane, Pearse A and Denniston, Alastair K and Nirantharakumar, Krishnarajah and Adderley, Nicola J},
  title   = {{Pharmacologic Treatments for Dementia and the Risk of Developing Age-Related Macular Degeneration}},
  journal = {JAMA network open},
  year    = {2024},
  doi     = {10.1001/jamanetworkopen.2024.41166},
  pmid    = {39446320},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.41166}
}

@article{deliyannides2023-37732619,
  author  = {Deliyannides, Deborah A and Graff, Jamie A and Niño, Izael and Lee, Seonjoo and Husain, Mustafa M and Forester, Brent P and Crocco, Elizabeth and Vahia, Ipsit V and others},
  title   = {{Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation}},
  journal = {International journal of geriatric psychiatry},
  year    = {2023},
  doi     = {10.1002/gps.6002},
  pmid    = {37732619},
  url     = {https://doi.org/10.1002/gps.6002}
}

@article{cohen2023-37874099,
  author  = {Cohen, S and van Dyck, C H and Gee, M and Doherty, T and Kanekiyo, M and Dhadda, S and Li, D and Hersch, S and others},
  title   = {{Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer's Disease}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2023},
  doi     = {10.14283/jpad.2023.123},
  pmid    = {37874099},
  url     = {https://doi.org/10.14283/jpad.2023.123}
}

@article{forlenza2019-30947755,
  author  = {Forlenza, Orestes V and Radanovic, Márcia and Talib, Leda L and Gattaz, Wagner F},
  title   = {{Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2019},
  doi     = {10.1192/bjp.2019.76},
  pmid    = {30947755},
  url     = {https://doi.org/10.1192/bjp.2019.76}
}

@article{farlow2019-30530975,
  author  = {Farlow, Martin R and Thompson, Richard E and Wei, Lee-Jen and Tuchman, Alan J and Grenier, Elaine and Crockford, David and Wilke, Susanne and Benison, Jeffrey and others},
  title   = {{A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-180759},
  pmid    = {30530975},
  url     = {https://doi.org/10.3233/jad-180759}
}

@article{lovestone2015-25537011,
  author  = {Lovestone, S. and Boada, M. and Dubois, B. and Hüll, M. and Rinne, J. O. and Huppertz, H. J. and Calero, M. and Andrés, M. V. and others},
  title   = {{A phase II trial of tideglusib in Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2015},
  doi     = {10.3233/jad-141959},
  pmid    = {25537011},
  url     = {https://doi.org/10.3233/jad-141959}
}

@article{faux2010-20164561,
  author  = {Faux, N. G. and Ritchie, C. W. and Gunn, A. and Rembach, A. and Tsatsanis, A. and Bedo, J. and Harrison, J. and Lannfelt, L. and others},
  title   = {{PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2010},
  doi     = {10.3233/jad-2010-1390},
  pmid    = {20164561},
  url     = {https://doi.org/10.3233/jad-2010-1390}
}

@article{aarsland2009-19520613,
  author  = {Aarsland, D. and Ballard, C. and Walker, Z. and Bostrom, F. and Alves, G. and Kossakowski, K. and Leroi, I. and Pozo-Rodriguez, F. and others},
  title   = {{Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial}},
  journal = {The Lancet. Neurology},
  year    = {2009},
  doi     = {10.1016/s1474-4422(09)70146-2},
  pmid    = {19520613},
  url     = {https://doi.org/10.1016/s1474-4422(09)70146-2}
}

@article{lannfelt2008-18672400,
  author  = {Lannfelt, L. and Blennow, K. and Zetterberg, H. and Batsman, S. and Ames, D. and Harrison, J. and Masters, C. L. and Targum, S. and others},
  title   = {{Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial}},
  journal = {The Lancet. Neurology},
  year    = {2008},
  doi     = {10.1016/s1474-4422(08)70167-4},
  pmid    = {18672400},
  url     = {https://doi.org/10.1016/s1474-4422(08)70167-4}
}

@article{serfaty2002-12461760,
  author  = {Serfaty, Marc and Kennell-Webb, Sandra and Warner, James and Blizard, Robert and Raven, Peter},
  title   = {{Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia}},
  journal = {International journal of geriatric psychiatry},
  year    = {2002},
  doi     = {10.1002/gps.760},
  pmid    = {12461760},
  url     = {https://doi.org/10.1002/gps.760}
}

@article{rockwood1997-9164692,
  author  = {Rockwood, K and Beattie, B L and Eastwood, M R and Feldman, H and Mohr, E and Pryse-Phillips, W and Gauthier, S},
  title   = {{A randomized, controlled trial of linopirdine in the treatment of Alzheimer's disease}},
  journal = {The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  year    = {1997},
  doi     = {10.1017/s031716710002148x},
  pmid    = {9164692},
  url     = {https://doi.org/10.1017/s031716710002148x}
}

@article{norgaard2022-35229024,
  author  = {Nørgaard, C. H. and Friedrich, S. and Hansen, C. T. and Gerds, T. and Ballard, C. and Møller, D. V. and Knudsen, L. B. and Kvist, K. and others},
  title   = {{Treatment with glucagon-like peptide-1 receptor agonists and incidence of dementia: Data from pooled double-blind randomized controlled trials and nationwide disease and prescription registers}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12268},
  pmid    = {35229024},
  url     = {https://doi.org/10.1002/trc2.12268}
}

@article{ackley2021-33632704,
  author  = {Ackley, S. F. and Zimmerman, S. C. and Brenowitz, W. D. and Tchetgen Tchetgen, E. J. and Gold, A. L. and Manly, J. J. and Mayeda, E. R. and Filshtein, T. J. and others},
  title   = {{Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2021},
  doi     = {10.1136/bmj.n156},
  pmid    = {33632704},
  url     = {https://doi.org/10.1136/bmj.n156}
}

@article{delnomdedieu2016-26925577,
  author  = {Delnomdedieu, M. and Duvvuri, S. and Li, D. J. and Atassi, N. and Lu, M. and Brashear, H. R. and Liu, E. and Ness, S. and others},
  title   = {{First-In-Human safety and long-term exposure data for AAB-003 (PF-05236812) and biomarkers after intravenous infusions of escalating doses in patients with mild to moderate Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2016},
  doi     = {10.1186/s13195-016-0177-y},
  pmid    = {26925577},
  url     = {https://doi.org/10.1186/s13195-016-0177-y}
}

@article{luchsinger2016-26890736,
  author  = {Luchsinger, J. A. and Perez, T. and Chang, H. and Mehta, P. and Steffener, J. and Pradabhan, G. and Ichise, M. and Manly, J. and others},
  title   = {{Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2016},
  doi     = {10.3233/jad-150493},
  pmid    = {26890736},
  url     = {https://doi.org/10.3233/jad-150493}
}

@article{gold2010-20733306,
  author  = {Gold, M. and Alderton, C. and Zvartau-Hind, M. and Egginton, S. and Saunders, A. M. and Irizarry, M. and Craft, S. and Landreth, G. and others},
  title   = {{Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study}},
  journal = {Dementia and geriatric cognitive disorders},
  year    = {2010},
  doi     = {10.1159/000318845},
  pmid    = {20733306},
  url     = {https://doi.org/10.1159/000318845}
}

@article{howard2007-17914039,
  author  = {Howard, R. J. and Juszczak, E. and Ballard, C. G. and Bentham, P. and Brown, R. G. and Bullock, R. and Burns, A. S. and Holmes, C. and others},
  title   = {{Donepezil for the treatment of agitation in Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2007},
  doi     = {10.1056/nejmoa066583},
  pmid    = {17914039},
  url     = {https://doi.org/10.1056/nejmoa066583}
}

@article{winblad2007-17380489,
  author  = {Winblad, B. and Cummings, J. and Andreasen, N. and Grossberg, G. and Onofrj, M. and Sadowsky, C. and Zechner, S. and Nagel, J. and others},
  title   = {{A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease--rivastigmine patch versus capsule}},
  journal = {International journal of geriatric psychiatry},
  year    = {2007},
  doi     = {10.1002/gps.1788},
  pmid    = {17380489},
  url     = {https://doi.org/10.1002/gps.1788}
}

@article{olazaran2004-15623698,
  author  = {Olazarán, J. and Muñiz, R. and Reisberg, B. and Peña-Casanova, J. and del Ser, T. and Cruz-Jentoft, A. J. and Serrano, P. and Navarro, E. and others},
  title   = {{Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000147478.03911.28},
  pmid    = {15623698},
  url     = {https://doi.org/10.1212/01.wnl.0000147478.03911.28}
}

@article{lanctot2003-12975222,
  author  = {Lanctôt, K. L. and Herrmann, N. and Yau, K. K. and Khan, L. R. and Liu, B. A. and LouLou, M. M. and Einarson, T. R.},
  title   = {{Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis}},
  journal = {CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne},
  year    = {2003},
  pmid    = {12975222}
}

@article{rogers1996-8915035,
  author  = {Rogers, S. L. and Friedhoff, L. T.},
  title   = {{The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial. The Donepezil Study Group}},
  journal = {Dementia (Basel, Switzerland)},
  year    = {1996},
  doi     = {10.1159/000106895},
  pmid    = {8915035},
  url     = {https://doi.org/10.1159/000106895}
}

@article{mccullough2025-40660741,
  author  = {McCullough, Austin and Chen, Charles D and Gordon, Brian A and Joseph-Mathurin, Nelly and Jack, Clifford R and Koeppe, Robert and Hornbeck, Russ and Koudelis, Deborah and others},
  title   = {{Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN-TU-001 trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70347},
  pmid    = {40660741},
  url     = {https://doi.org/10.1002/alz.70347}
}

@article{holdridge2023-36946603,
  author  = {Holdridge, Karen C and Yaari, Roy and Hoban, Deirdre B and Andersen, Scott and Sims, John R},
  title   = {{Targeting amyloid β in Alzheimer's disease: Meta-analysis of low-dose solanezumab in Alzheimer's disease with mild dementia studies}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.13031},
  pmid    = {36946603},
  url     = {https://doi.org/10.1002/alz.13031}
}

@article{dai2022-36186728,
  author  = {Dai, Jiahui and Ports, Kayleen Deanna and Corrada, Maria M and Odegaard, Andrew O and O'Connell, Joan and Jiang, Luohua},
  title   = {{Metformin and Dementia Risk: A Systematic Review with Respect to Time Related Biases}},
  journal = {Journal of Alzheimer's disease reports},
  year    = {2022},
  doi     = {10.3233/adr-220002},
  pmid    = {36186728},
  url     = {https://doi.org/10.3233/adr-220002}
}

@article{masurkar2022-34854475,
  author  = {Masurkar, Prajakta P and Chatterjee, Satabdi and Sherer, Jeffrey T and Chen, Hua and Johnson, Michael L and Aparasu, Rajender R},
  title   = {{Risk of overactive bladder associated with cholinesterase inhibitors in dementia}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2022},
  doi     = {10.1111/jgs.17579},
  pmid    = {34854475},
  url     = {https://doi.org/10.1111/jgs.17579}
}

@article{masurkar2021-34027602,
  author  = {Masurkar, Prajakta P and Chatterjee, Satabdi and Sherer, Jeffrey T and Aparasu, Rajender R},
  title   = {{Antimuscarinic Cascade Across Individual Cholinesterase Inhibitors in Older Adults with Dementia}},
  journal = {Drugs \& aging},
  year    = {2021},
  doi     = {10.1007/s40266-021-00863-5},
  pmid    = {34027602},
  url     = {https://doi.org/10.1007/s40266-021-00863-5}
}

@article{rege2021-33763822,
  author  = {Rege, Sanika and Carnahan, Ryan M and Johnson, Michael L and Chen, Hua and Holmes, Holly M and Aparasu, Rajender R},
  title   = {{Antipsychotic Initiation Among Older Dementia Patients Using Cholinesterase Inhibitors: A National Retrospective Cohort Study}},
  journal = {Drugs \& aging},
  year    = {2021},
  doi     = {10.1007/s40266-021-00851-9},
  pmid    = {33763822},
  url     = {https://doi.org/10.1007/s40266-021-00851-9}
}

@article{desousa2021-33095371,
  author  = {De Sousa, Ricardo Augusto Leoni and Rodrigues, Cíntia Maria and Mendes, Bruno Ferreira and Improta-Caria, Alex Cleber and Peixoto, Marco Fabrício Dias and Cassilhas, Ricardo Cardoso},
  title   = {{Physical exercise protocols in animal models of Alzheimer's disease: a systematic review}},
  journal = {Metabolic brain disease},
  year    = {2021},
  doi     = {10.1007/s11011-020-00633-z},
  pmid    = {33095371},
  url     = {https://doi.org/10.1007/s11011-020-00633-z}
}

@article{petracca1996-8854297,
  author  = {Petracca, G and Tesón, A and Chemerinski, E and Leiguarda, R and Starkstein, S E},
  title   = {{A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease}},
  journal = {The Journal of neuropsychiatry and clinical neurosciences},
  year    = {1996},
  doi     = {10.1176/jnp.8.3.270},
  pmid    = {8854297},
  url     = {https://doi.org/10.1176/jnp.8.3.270}
}

@article{wolters1990-2192301,
  author  = {Wolters, E C and Riekkinen, P and Lowenthal, A and Van der Plaats, J J and Zwart, J M and Sennef, C},
  title   = {{DGAVP (Org 5667) in early Alzheimer's disease patients: an international double-blind, placebo-controlled, multicenter trial}},
  journal = {Neurology},
  year    = {1990},
  doi     = {10.1212/wnl.40.7.1099},
  pmid    = {2192301},
  url     = {https://doi.org/10.1212/wnl.40.7.1099}
}

@article{chundu2025-40621323,
  author  = {Chundu, U. C. and Thiriveedhi, SR. and Bhatti, C. and Mupparaju, J. S. and Otinashvili, N. and Gelishvili, E.},
  title   = {{A Systematic Review of the Efficacy and Safety of Anti-amyloid Monoclonal Antibodies in Alzheimer's Disease}},
  journal = {Cureus},
  year    = {2025},
  doi     = {10.7759/cureus.85377},
  pmid    = {40621323},
  url     = {https://doi.org/10.7759/cureus.85377}
}

@article{wang2025-40308765,
  author  = {Wang, H. and Pan, J. and Zhang, M. and Tan, Z.},
  title   = {{Re-evaluation of the efficacy and safety of anti-Aβ monoclonal antibodies (lecanemab/donanemab) in the treatment of early Alzheimer's disease}},
  journal = {Frontiers in pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1599048},
  pmid    = {40308765},
  url     = {https://doi.org/10.3389/fphar.2025.1599048}
}

@article{avgerinos2024-39468148,
  author  = {Avgerinos, K. I. and Manolopoulos, A. and Ferrucci, L. and Kapogiannis, D.},
  title   = {{Critical assessment of anti-amyloid-β monoclonal antibodies effects in Alzheimer's disease: a systematic review and meta-analysis highlighting target engagement and clinical meaningfulness}},
  journal = {Scientific reports},
  year    = {2024},
  doi     = {10.1038/s41598-024-75204-8},
  pmid    = {39468148},
  url     = {https://doi.org/10.1038/s41598-024-75204-8}
}

@article{abdelazim2024-38565747,
  author  = {Abdelazim, K. and Allam, A. A. and Afifi, B. and Abdulazeem, H. and Elbehiry, A. I.},
  title   = {{The efficacy and safety of lecanemab 10 mg/kg biweekly compared to a placebo in patients with Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials}},
  journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
  year    = {2024},
  doi     = {10.1007/s10072-024-07477-w},
  pmid    = {38565747},
  url     = {https://doi.org/10.1007/s10072-024-07477-w}
}

@article{tian2023-37302139,
  author  = {Tian, S. and Jiang, J. and Wang, J. and Zhang, Z. and Miao, Y. and Ji, X. and Bi, Y.},
  title   = {{Comparison on cognitive outcomes of antidiabetic agents for type 2 diabetes: A systematic review and network meta-analysis}},
  journal = {Diabetes/metabolism research and reviews},
  year    = {2023},
  doi     = {10.1002/dmrr.3673},
  pmid    = {37302139},
  url     = {https://doi.org/10.1002/dmrr.3673}
}

@article{salloway2018-29914022,
  author  = {Salloway, S. P. and Sperling, R. and Fox, N. C. and Sabbagh, M. N. and Honig, L. S. and Porsteinsson, A. P. and Rofael, H. and Ketter, N. and others},
  title   = {{Long-Term Follow Up of Patients with Mild-to-Moderate Alzheimer's Disease Treated with Bapineuzumab in a Phase III, Open-Label, Extension Study}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-171157},
  pmid    = {29914022},
  url     = {https://doi.org/10.3233/jad-171157}
}

@article{chen2017-28784164,
  author  = {Chen, C. K. and Wu, Y. T. and Chang, Y. C.},
  title   = {{Association between chronic periodontitis and the risk of Alzheimer's disease: a retrospective, population-based, matched-cohort study}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0282-6},
  pmid    = {28784164},
  url     = {https://doi.org/10.1186/s13195-017-0282-6}
}

@article{giugliano2017-28207168,
  author  = {Giugliano, R. P. and Mach, F. and Zavitz, K. and Kurtz, C. and Schneider, J. and Wang, H. and Keech, A. and Pedersen, T. R. and others},
  title   = {{Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-A cognitive study of patients enrolled in the FOURIER trial}},
  journal = {Clinical cardiology},
  year    = {2017},
  doi     = {10.1002/clc.22678},
  pmid    = {28207168},
  url     = {https://doi.org/10.1002/clc.22678}
}

@article{matsunaga2015-26402004,
  author  = {Matsunaga, S. and Kishi, T. and Annas, P. and Basun, H. and Hampel, H. and Iwata, N.},
  title   = {{Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2015},
  doi     = {10.3233/jad-150437},
  pmid    = {26402004},
  url     = {https://doi.org/10.3233/jad-150437}
}

@article{avilesolmos2014-24662192,
  author  = {Aviles-Olmos, I. and Dickson, J. and Kefalopoulou, Z. and Djamshidian, A. and Kahan, J. and Ell, P. and Whitton, P. and Wyse, R. and others},
  title   = {{Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease}},
  journal = {Journal of Parkinson's disease},
  year    = {2014},
  doi     = {10.3233/jpd-140364},
  pmid    = {24662192},
  url     = {https://doi.org/10.3233/jpd-140364}
}

@article{forlenza2011-21525519,
  author  = {Forlenza, O. V. and Diniz, B. S. and Radanovic, M. and Santos, F. S. and Talib, L. L. and Gattaz, W. F.},
  title   = {{Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2011},
  doi     = {10.1192/bjp.bp.110.080044},
  pmid    = {21525519},
  url     = {https://doi.org/10.1192/bjp.bp.110.080044}
}

@article{winblad2006-16581404,
  author  = {Winblad, B. and Kilander, L. and Eriksson, S. and Minthon, L. and Båtsman, S. and Wetterholm, A. L. and Jansson-Blixt, C. and Haglund, A. and others},
  title   = {{Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study}},
  journal = {Lancet (London, England)},
  year    = {2006},
  doi     = {10.1016/s0140-6736(06)68350-5},
  pmid    = {16581404},
  url     = {https://doi.org/10.1016/s0140-6736(06)68350-5}
}

@article{risner2006-16446752,
  author  = {Risner, M. E. and Saunders, A. M. and Altman, J. F. and Ormandy, G. C. and Craft, S. and Foley, I. M. and Zvartau-Hind, M. E. and Hosford, D. A. and others},
  title   = {{Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease}},
  journal = {The pharmacogenomics journal},
  year    = {2006},
  doi     = {10.1038/sj.tpj.6500369},
  pmid    = {16446752},
  url     = {https://doi.org/10.1038/sj.tpj.6500369}
}

@article{hock2003-12765607,
  author  = {Hock, C. and Konietzko, U. and Streffer, JR. and Tracy, J. and Signorell, A. and Müller-Tillmanns, B. and Lemke, U. and Henke, K. and others},
  title   = {{Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00294-0},
  pmid    = {12765607},
  url     = {https://doi.org/10.1016/s0896-6273(03)00294-0}
}

@article{abouelmagd2025-41188985,
  author  = {Abouelmagd, Moaz Elsayed and Almosilhy, Nereen A and Makhlouf, Hamdy A and Hassan, Amr K and Osman, Ahmed S A and Hindawi, Mahmoud Diaa and Elshahat, Ahmed and Alnajjar, Asmaa Zakria and others},
  title   = {{Comparative safety of cholinesterase inhibitors and memantine for dementia: a protocol for a network meta-analysis of randomized controlled trials}},
  journal = {Systematic reviews},
  year    = {2025},
  doi     = {10.1186/s13643-025-02961-6},
  pmid    = {41188985},
  url     = {https://doi.org/10.1186/s13643-025-02961-6}
}

@article{bereczki2025-41145344,
  author  = {Bereczki, Erika and Mangialasche, Francesca and Barbera, Mariagnese and Padilla, Paola and Hara, Yuko and Fillit, Howard and Solomon, Alina and Kivipelto, Miia},
  title   = {{Risk reduction and precision prevention across the Alzheimer's disease continuum: a systematic review of clinical trials combining multidomain lifestyle interventions and pharmacological or nutraceutical approaches}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100367},
  pmid    = {41145344},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100367}
}

@article{dodel2025-40790925,
  author  = {Dodel, Richard and Frölich, Lutz},
  title   = {{Donanemab for Alzheimer's disease: from preclinical research to the clinical application}},
  journal = {Expert review of neurotherapeutics},
  year    = {2025},
  doi     = {10.1080/14737175.2025.2546868},
  pmid    = {40790925},
  url     = {https://doi.org/10.1080/14737175.2025.2546868}
}

@article{su2025-40473116,
  author  = {Su, Ching-Hui and Chang, Ying-Tzu and Tseng, Huan-Shu and Kuo, Chan-Yen and Chen, Jin-Hua and Chien, Po-Yu and Chang, Yao-Jen and Hung, Chin-Chuan},
  title   = {{Comparisons of efficacy and safety of immunotherapies for Alzheimer's disease treatment: A network meta-analysis of randomised controlled trials}},
  journal = {Clinical medicine (London, England)},
  year    = {2025},
  doi     = {10.1016/j.clinme.2025.100336},
  pmid    = {40473116},
  url     = {https://doi.org/10.1016/j.clinme.2025.100336}
}

@article{bregman2025-40437535,
  author  = {Bregman, N. and Nathan, T. and Shir, D. and Omer, N. and Levy, M. H. and David, A. B. and Aizenstien, O. and Lotan, E. and others},
  title   = {{Lecanemab in clinical practice: real-world outcomes in early Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01763-1},
  pmid    = {40437535},
  url     = {https://doi.org/10.1186/s13195-025-01763-1}
}

@article{chhabra2024-39432414,
  author  = {Chhabra, Akanksha and Solanki, Siddhant and Saravanabawan, Prithvi and Venkiteswaran, Arun and Nimmathota, NagaTarang and Modi, Nishi Manojkumar},
  title   = {{A systematic review of the efficacy and safety of anti-amyloid beta monoclonal antibodies in treatment of Alzheimer's disease}},
  journal = {Expert opinion on biological therapy},
  year    = {2024},
  doi     = {10.1080/14712598.2024.2416947},
  pmid    = {39432414},
  url     = {https://doi.org/10.1080/14712598.2024.2416947}
}

@article{terao2024-39598397,
  author  = {Terao, Takeshi and Hirakawa, Hirofumi and Muronaga, Masaaki and Izumi, Toshihiko and Kohno, Kentaro},
  title   = {{Trace Lithium for Suicide Prevention and Dementia Prevention: A Qualitative Review}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2024},
  doi     = {10.3390/ph17111486},
  pmid    = {39598397},
  url     = {https://doi.org/10.3390/ph17111486}
}

@article{gao2024-38439609,
  author  = {Gao, Yaqi and Liu, Yulin and Li, Yanfang},
  title   = {{Safety and efficacy of acetylcholinesterase inhibitors for Alzheimer's disease: A systematic review and meta-analysis}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2024},
  doi     = {10.17219/acem/176051},
  pmid    = {38439609},
  url     = {https://doi.org/10.17219/acem/176051}
}

@article{nelson2025-39366871,
  author  = {Nelson, J Craig and Gandelman, Jason A and Mackin, R Scott},
  title   = {{A Systematic Review of Antidepressants and Psychotherapy Commonly Used in the Treatment of Late Life Depression for Their Effects on Cognition}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2025},
  doi     = {10.1016/j.jagp.2024.08.015},
  pmid    = {39366871},
  url     = {https://doi.org/10.1016/j.jagp.2024.08.015}
}

@article{chen2024-38640313,
  author  = {Chen, Yan and Lai, Min and Tao, Ming},
  title   = {{Evaluating the efficacy and safety of Alzheimer's disease drugs: A meta-analysis and systematic review}},
  journal = {Medicine},
  year    = {2024},
  doi     = {10.1097/md.0000000000037799},
  pmid    = {38640313},
  url     = {https://doi.org/10.1097/md.0000000000037799}
}

@article{ma2024-38592337,
  author  = {Ma, Xiao-Na and Feng, Wei and Chen, Shu-Lin and Zhong, Xiao-Qin and Lin, Chang-Song and Xu, Qiang},
  title   = {{Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study}},
  journal = {Neurology and therapy},
  year    = {2024},
  doi     = {10.1007/s40120-024-00609-6},
  pmid    = {38592337},
  url     = {https://doi.org/10.1007/s40120-024-00609-6}
}

@article{knopman2023-37295957,
  author  = {Knopman, D. S. and Hershey, L.},
  title   = {{Implications of the Approval of Lecanemab for Alzheimer Disease Patient Care: Incremental Step or Paradigm Shift?}},
  journal = {Neurology},
  year    = {2023},
  doi     = {10.1212/wnl.0000000000207438},
  pmid    = {37295957},
  url     = {https://doi.org/10.1212/wnl.0000000000207438}
}

@article{villain2022-36184326,
  author  = {Villain, N. and Planche, V. and Levy, R.},
  title   = {{High-clearance anti-amyloid immunotherapies in Alzheimer's disease. Part 1: Meta-analysis and review of efficacy and safety data, and medico-economical aspects}},
  journal = {Revue neurologique},
  year    = {2022},
  doi     = {10.1016/j.neurol.2022.06.012},
  pmid    = {36184326},
  url     = {https://doi.org/10.1016/j.neurol.2022.06.012}
}

@article{lacorte2022-35275549,
  author  = {Lacorte, E. and Ancidoni, A. and Zaccaria, V. and Remoli, G. and Tariciotti, L. and Bellomo, G. and Sciancalepore, F. and Corbo, M. and others},
  title   = {{Safety and Efficacy of Monoclonal Antibodies for Alzheimer's Disease: A Systematic Review and Meta-Analysis of Published and Unpublished Clinical Trials}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220046},
  pmid    = {35275549},
  url     = {https://doi.org/10.3233/jad-220046}
}

@article{carney2019-31921965,
  author  = {Carney, Greg and Bassett, Ken and Wright, James M and Maclure, Malcolm and McGuire, Nicolette and Dormuth, Colin R},
  title   = {{Comparison of cholinesterase inhibitor safety in real-world practice}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2019},
  doi     = {10.1016/j.trci.2019.09.011},
  pmid    = {31921965},
  url     = {https://doi.org/10.1016/j.trci.2019.09.011}
}

@article{bhattacharjee2019-31338414,
  author  = {Bhattacharjee, Sandipan and Patanwala, Asad E and Lo-Ciganic, Wei-Hsuan and Malone, Daniel C and Lee, Jeannie K and Knapp, Shannon M and Warholak, Terri and Burke, William J},
  title   = {{Alzheimer's disease medication and risk of all-cause mortality and all-cause hospitalization: A retrospective cohort study}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2019},
  doi     = {10.1016/j.trci.2019.05.005},
  pmid    = {31338414},
  url     = {https://doi.org/10.1016/j.trci.2019.05.005}
}

@article{green2019-30652263,
  author  = {Green, A. R. and Reifler, L. M. and Bayliss, E. A. and Weffald, L. A. and Boyd, C. M.},
  title   = {{Drugs Contributing to Anticholinergic Burden and Risk of Fall or Fall-Related Injury among Older Adults with Mild Cognitive Impairment, Dementia and Multiple Chronic Conditions: A Retrospective Cohort Study}},
  journal = {Drugs \& aging},
  year    = {2019},
  doi     = {10.1007/s40266-018-00630-z},
  pmid    = {30652263},
  url     = {https://doi.org/10.1007/s40266-018-00630-z}
}

@article{nguyen2018-30080934,
  author  = {Nguyen, C. and Lairson, D. R. and Swartz, M. D. and Du, X. L.},
  title   = {{Risks of Major Long-Term Side Effects Associated with Androgen-Deprivation Therapy in Men with Prostate Cancer}},
  journal = {Pharmacotherapy},
  year    = {2018},
  doi     = {10.1002/phar.2168},
  pmid    = {30080934},
  url     = {https://doi.org/10.1002/phar.2168}
}

@article{cheng2017-28002662,
  author  = {Cheng, Chin and Zandi, Peter and Stuart, Elizabeth and Lin, Ching-Heng and Su, Pei-Yu and Alexander, G Caleb and Lan, Tsuo-Hung},
  title   = {{Association Between Lithium Use and Risk of Alzheimer's Disease}},
  journal = {The Journal of clinical psychiatry},
  year    = {2017},
  doi     = {10.4088/jcp.15m10304},
  pmid    = {28002662},
  url     = {https://doi.org/10.4088/jcp.15m10304}
}

@article{sheehan2015-26330451,
  author  = {Sheehan, Rory and Hassiotis, Angela and Walters, Kate R and Osborn, David and Strydom, André and Horsfall, Laura},
  title   = {{Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study}},
  journal = {BMJ},
  year    = {2015},
  doi     = {10.1136/bmj.h4326},
  pmid    = {26330451},
  url     = {https://doi.org/10.1136/bmj.h4326}
}

@article{delser2013-22936007,
  author  = {del Ser, T. and Steinwachs, K. C. and Gertz, H. J. and Andrés, M. V. and Gómez-Carrillo, B. and Medina, M. and Vericat, J. A. and Redondo, P. and others},
  title   = {{Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-2012-120805},
  pmid    = {22936007},
  url     = {https://doi.org/10.3233/jad-2012-120805}
}

@article{trompet2010-19653027,
  author  = {Trompet, S. and van Vliet, P. and de Craen, A. J. and Jolles, J. and Buckley, B. M. and Murphy, M. B. and Ford, I. and Macfarlane, P. W. and others},
  title   = {{Pravastatin and cognitive function in the elderly. Results of the PROSPER study}},
  journal = {Journal of neurology},
  year    = {2010},
  doi     = {10.1007/s00415-009-5271-7},
  pmid    = {19653027},
  url     = {https://doi.org/10.1007/s00415-009-5271-7}
}

@article{wagstaff2003-12885101,
  author  = {Wagstaff, L. R. and Mitton, M. W. and Arvik, B. M. and Doraiswamy, P. M.},
  title   = {{Statin-associated memory loss: analysis of 60 case reports and review of the literature}},
  journal = {Pharmacotherapy},
  year    = {2003},
  doi     = {10.1592/phco.23.7.871.32720},
  pmid    = {12885101},
  url     = {https://doi.org/10.1592/phco.23.7.871.32720}
}

@article{walker1996-9038610,
  author  = {Walker, L. G. and Wesnes, K. P. and Heys, S. D. and Walker, M. B. and Lolley, J. and Eremin, O.},
  title   = {{The cognitive effects of recombinant interleukin-2 (rIL-2) therapy: a controlled clinical trial using computerised assessments}},
  journal = {European journal of cancer (Oxford, England : 1990)},
  year    = {1996},
  doi     = {10.1016/s0959-8049(96)00300-0},
  pmid    = {9038610},
  url     = {https://doi.org/10.1016/s0959-8049(96)00300-0}
}

@article{tang1996-8709781,
  author  = {Tang, M. X. and Jacobs, D. and Stern, Y. and Marder, K. and Schofield, P. and Gurland, B. and Andrews, H. and Mayeux, R.},
  title   = {{Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease}},
  journal = {Lancet (London, England)},
  year    = {1996},
  doi     = {10.1016/s0140-6736(96)03356-9},
  pmid    = {8709781},
  url     = {https://doi.org/10.1016/s0140-6736(96)03356-9}
}

@article{summers1986-2430180,
  author  = {Summers, W. K. and Majovski, L. V. and Marsh, G. M. and Tachiki, K. and Kling, A.},
  title   = {{Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type}},
  journal = {The New England journal of medicine},
  year    = {1986},
  doi     = {10.1056/nejm198611133152001},
  pmid    = {2430180},
  url     = {https://doi.org/10.1056/nejm198611133152001}
}

@article{shimasaki2026-41936348,
  author  = {Shimasaki, Ryosuke and Kurihara, Masanori and Bannai, Taro and Hatano, Keiko and Suzuki, Fumio and Tokumaru, Aya Midori and Ishii, Kenji and Ihara, Ryoko and others},
  title   = {{Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2026},
  doi     = {10.1016/j.tjpad.2026.100562},
  pmid    = {41936348},
  url     = {https://doi.org/10.1016/j.tjpad.2026.100562}
}

@article{shang2025-41250246,
  author  = {Shang, Jia and Zhong, Siyan and Shang, Li and Zeng, Qingze and Zhao, Shuai and Luo, Xiao and Li, Kaicheng and Zhang, Xinyi and others},
  title   = {{Real-world application of lecanemab in early-stage alzheimer's disease: a single-center prospective cohort analysis}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01886-5},
  pmid    = {41250246},
  url     = {https://doi.org/10.1186/s13195-025-01886-5}
}

@article{vanderoovaart2023-38004378,
  author  = {Van de Roovaart, Hannah J and Nguyen, Nguyen and Veenstra, Timothy D},
  title   = {{Huntington's Disease Drug Development: A Phase 3 Pipeline Analysis}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/ph16111513},
  pmid    = {38004378},
  url     = {https://doi.org/10.3390/ph16111513}
}

@article{ioakeimskoufa2023-37296934,
  author  = {Ioakeim-Skoufa, Ignatios and Tobajas-Ramos, Natalia and Menditto, Enrica and Aza-Pascual-Salcedo, Mercedes and Gimeno-Miguel, Antonio and Orlando, Valentina and González-Rubio, Francisca and Fanlo-Villacampa, Ana and others},
  title   = {{Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials}},
  journal = {Cancers},
  year    = {2023},
  doi     = {10.3390/cancers15112972},
  pmid    = {37296934},
  url     = {https://doi.org/10.3390/cancers15112972}
}

@article{rahman2023-36775284,
  author  = {Rahman, Afroza and Hossen, Md Anwar and Chowdhury, Mirza Farhana Iqbal and Bari, Sadia and Tamanna, Nuzhat and Sultana, Syeda Salima and Haque, Sharar Naiarin and Masud, Abdullah Al and others},
  title   = {{Aducanumab for the treatment of Alzheimer's disease: a systematic review}},
  journal = {Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society},
  year    = {2023},
  doi     = {10.1111/psyg.12944},
  pmid    = {36775284},
  url     = {https://doi.org/10.1111/psyg.12944}
}

@article{jang2022-36440278,
  author  = {Jang, Ha Young and Oh, Jung Mi and Kim, In-Wha},
  title   = {{Drug repurposing using meta-analysis of gene expression in Alzheimer's disease}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.989174},
  pmid    = {36440278},
  url     = {https://doi.org/10.3389/fnins.2022.989174}
}

@article{pozzi2022-36203811,
  author  = {Pozzi, Federico Emanuele and Conti, Elisa and Appollonio, Ildebrando and Ferrarese, Carlo and Tremolizzo, Lucio},
  title   = {{Predictors of response to acetylcholinesterase inhibitors in dementia: A systematic review}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.998224},
  pmid    = {36203811},
  url     = {https://doi.org/10.3389/fnins.2022.998224}
}

@article{alexander2022-36245899,
  author  = {Alexander, Peter and Visagan, Shakthi and Jawhar, Sara and Kare, Amogh and Issa, Noor and Issa, Reem and Jawhar, Abbas and Thomas, Sneha and others},
  title   = {{Antiplatelets and Vascular Dementia: A Systematic Review}},
  journal = {Journal of aging research},
  year    = {2022},
  doi     = {10.1155/2022/9780067},
  pmid    = {36245899},
  url     = {https://doi.org/10.1155/2022/9780067}
}

@article{ancidoni2021-33952306,
  author  = {Ancidoni, Antonio and Bacigalupo, Ilaria and Remoli, Giulia and Lacorte, Eleonora and Piscopo, Paola and Sarti, Giulia and Corbo, Massimo and Vanacore, Nicola and others},
  title   = {{Anticancer drugs repurposed for Alzheimer's disease: a systematic review}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00831-6},
  pmid    = {33952306},
  url     = {https://doi.org/10.1186/s13195-021-00831-6}
}

@article{siemers2016-26238576,
  author  = {Siemers, E. R. and Sundell, K. L. and Carlson, C. and Case, M. and Sethuraman, G. and Liu-Seifert, H. and Dowsett, S. A. and Pontecorvo, M. J. and others},
  title   = {{Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2015.06.1893},
  pmid    = {26238576},
  url     = {https://doi.org/10.1016/j.jalz.2015.06.1893}
}

@article{doody2008-18640457,
  author  = {Doody, R. S. and Gavrilova, S. I. and Sano, M. and Thomas, R. G. and Aisen, P. S. and Bachurin, S. O. and Seely, L. and Hung, D. and others},
  title   = {{Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study}},
  journal = {Lancet (London, England)},
  year    = {2008},
  doi     = {10.1016/s0140-6736(08)61074-0},
  pmid    = {18640457},
  url     = {https://doi.org/10.1016/s0140-6736(08)61074-0}
}

@article{wang2025-40619285,
  author  = {Wang, Hong and Nery, Emel Serap Monkul and Ardayfio, Paul and Khanna, Rashna and Svaldi, Diana Otero and Shcherbinin, Sergey and Xu, Wen and Andersen, Scott W and others},
  title   = {{The effect of modified donanemab titration on amyloid-related imaging abnormalities with edema/effusions and amyloid reduction: 18-month results from TRAILBLAZER-ALZ 6}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100266},
  pmid    = {40619285},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100266}
}

@article{hey2025-39907966,
  author  = {Hey, J. A. and Yu, J. Y. and Abushakra, S. and Schaefer, J. F. and Power, A. and Kesslak, P. and Paul, J. and Tolar, M.},
  title   = {{Clinical Pharmacokinetics of Oral ALZ-801/Valiltramiprosate in a 2-Year Phase 2 Trial of APOE4 Carriers with Early Alzheimer's Disease}},
  journal = {Clinical pharmacokinetics},
  year    = {2025},
  doi     = {10.1007/s40262-025-01482-8},
  pmid    = {39907966},
  url     = {https://doi.org/10.1007/s40262-025-01482-8}
}

@article{arroyopacheco2025-39638097,
  author  = {Arroyo-Pacheco, N. and Sarmiento-Blanco, S. and Vergara-Cadavid, G. and Castro-Leones, M. and Contreras-Puentes, N.},
  title   = {{Monoclonal therapy with lecanemab in the treatment of mild Alzheimer's disease: A systematic review and meta-analysis}},
  journal = {Ageing research reviews},
  year    = {2025},
  doi     = {10.1016/j.arr.2024.102620},
  pmid    = {39638097},
  url     = {https://doi.org/10.1016/j.arr.2024.102620}
}

@article{gilbert2018-30508430,
  author  = {Gilbert, Matthew Philip and Bain, Stephen Charles and Franek, Edward and Jódar-Gimeno, Esteban and Nauck, Michael Albrecht and Pratley, Richard E. and Rea, Rosangela Roginski and Saraiva, José Francisco Kerr and others},
  title   = {{Effect of Liraglutide on Cardiovascular Outcomes in Elderly Patients: A Post Hoc Analysis of a Randomized Controlled Trial}},
  journal = {Annals of Internal Medicine},
  year    = {2018},
  doi     = {10.7326/m18-1569},
  pmid    = {30508430},
  url     = {https://doi.org/10.7326/m18-1569}
}

@article{islam2016-28013304,
  author  = {Islam, M. M. and Iqbal, U. and Walther, B. and Atique, S. and Dubey, N. K. and Nguyen, P. A. and Poly, T. N. and Masud, J. H. and others},
  title   = {{Benzodiazepine Use and Risk of Dementia in the Elderly Population: A Systematic Review and Meta-Analysis}},
  journal = {Neuroepidemiology},
  year    = {2016},
  doi     = {10.1159/000454881},
  pmid    = {28013304},
  url     = {https://doi.org/10.1159/000454881}
}

@article{andreasen2015-25789616,
  author  = {Andreasen, N. and Simeoni, M. and Ostlund, H. and Lisjo, P. I. and Fladby, T. and Loercher, A. E. and Byrne, G. J. and Murray, F. and others},
  title   = {{First administration of the Fc-attenuated anti-β amyloid antibody GSK933776 to patients with mild Alzheimer's disease: a randomized, placebo-controlled study}},
  journal = {PloS one},
  year    = {2015},
  doi     = {10.1371/journal.pone.0098153},
  pmid    = {25789616},
  url     = {https://doi.org/10.1371/journal.pone.0098153}
}

@article{smeeth2009-19006546,
  author  = {Smeeth, L. and Douglas, I. and Hall, A. J. and Hubbard, R. and Evans, S.},
  title   = {{Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials}},
  journal = {British journal of clinical pharmacology},
  year    = {2009},
  doi     = {10.1111/j.1365-2125.2008.03308.x},
  pmid    = {19006546},
  url     = {https://doi.org/10.1111/j.1365-2125.2008.03308.x}
}

@article{schneider2006-17035647,
  author  = {Schneider, L. S. and Tariot, P. N. and Dagerman, K. S. and Davis, S. M. and Hsiao, J. K. and Ismail, M. S. and Lebowitz, B. D. and Lyketsos, C. G. and others},
  title   = {{Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2006},
  doi     = {10.1056/nejmoa061240},
  pmid    = {17035647},
  url     = {https://doi.org/10.1056/nejmoa061240}
}

@article{courtney2004-15220031,
  author  = {Courtney, C. and Farrell, D. and Gray, R. and Hills, R. and Lynch, L. and Sellwood, E. and Edwards, S. and Hardyman, W. and others},
  title   = {{Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial}},
  journal = {Lancet (London, England)},
  year    = {2004},
  doi     = {10.1016/s0140-6736(04)16499-4},
  pmid    = {15220031},
  url     = {https://doi.org/10.1016/s0140-6736(04)16499-4}
}

@article{winblad1999-10885864,
  author  = {Winblad, B. and Poritis, N.},
  title   = {{Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine)}},
  journal = {International journal of geriatric psychiatry},
  year    = {1999},
  doi     = {10.1002/(sici)1099-1166(199902)14:2<135::aid-gps906>3.0.co;2-0},
  pmid    = {10885864},
  url     = {https://doi.org/10.1002/(sici)1099-1166(199902)14:2<135::aid-gps906>3.0.co;2-0}
}

@article{farlow1992-1404819,
  author  = {Farlow, M. and Gracon, S. I. and Hershey, L. A. and Lewis, K. W. and Sadowsky, C. H. and Dolan-Ureno, J.},
  title   = {{A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group}},
  journal = {JAMA},
  year    = {1992},
  doi     = {10.1001/jama.1992.03490180055026},
  pmid    = {1404819},
  url     = {https://doi.org/10.1001/jama.1992.03490180055026}
}

@article{steventon2020-32017180,
  author  = {Steventon, Jessica J and Rosser, Anne E and Hart, Emma and Murphy, Kevin},
  title   = {{Hypertension, Antihypertensive Use and the Delayed-Onset of Huntington's Disease}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2020},
  doi     = {10.1002/mds.27976},
  pmid    = {32017180},
  url     = {https://doi.org/10.1002/mds.27976}
}

@article{fleet2019-31527187,
  author  = {Fleet, Jamie L and McArthur, Eric and Patel, Aakil and Weir, Matthew A and Montero-Odasso, Manuel and Garg, Amit X},
  title   = {{Risk of rhabdomyolysis with donepezil compared with rivastigmine or galantamine: a population-based cohort study}},
  journal = {CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne},
  year    = {2019},
  doi     = {10.1503/cmaj.190337},
  pmid    = {31527187},
  url     = {https://doi.org/10.1503/cmaj.190337}
}

@article{matsunaga2018-30222469,
  author  = {Matsunaga, Shinji and Kishi, Taro and Nomura, Ikuo and Sakuma, Kenji and Okuya, Makoto and Ikuta, Toshikazu and Iwata, Nakao},
  title   = {{The efficacy and safety of memantine for the treatment of Alzheimer's disease}},
  journal = {Expert opinion on drug safety},
  year    = {2018},
  doi     = {10.1080/14740338.2018.1524870},
  pmid    = {30222469},
  url     = {https://doi.org/10.1080/14740338.2018.1524870}
}

@article{ebrahem2018-29999427,
  author  = {Ebrahem, Anees Shajhan and Oremus, Mark},
  title   = {{A pharmacoeconomic evaluation of cholinesterase inhibitors and memantine for the treatment of Alzheimer's disease}},
  journal = {Expert opinion on pharmacotherapy},
  year    = {2018},
  doi     = {10.1080/14656566.2018.1499727},
  pmid    = {29999427},
  url     = {https://doi.org/10.1080/14656566.2018.1499727}
}

@article{wessels2018-29616706,
  author  = {Wessels, A M and Andersen, S W and Dowsett, S A and Siemers, E R},
  title   = {{The Integrated Alzheimer's Disease Rating Scale (iADRS) Findings from the EXPEDITION3 Trial}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2018},
  doi     = {10.14283/jpad.2018.10},
  pmid    = {29616706},
  url     = {https://doi.org/10.14283/jpad.2018.10}
}

@article{glynnservedio2017-28855009,
  author  = {Glynn-Servedio, Brianna E and Ranola, Trisha Seys},
  title   = {{AChE Inhibitors and NMDA Receptor Antagonists in Advanced Alzheimer's Disease}},
  journal = {The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists},
  year    = {2017},
  doi     = {10.4140/tcp.n.2017.511},
  pmid    = {28855009},
  url     = {https://doi.org/10.4140/tcp.n.2017.511}
}

@article{haussmann2017-27822591,
  author  = {Haussmann, R and Donix, M},
  title   = {{[Memantine as add-on medication to acetylcholinesterase inhibitor therapy for Alzheimer dementia]}},
  journal = {Der Nervenarzt},
  year    = {2017},
  doi     = {10.1007/s00115-016-0237-3},
  pmid    = {27822591},
  url     = {https://doi.org/10.1007/s00115-016-0237-3}
}

@article{flicker1994-8267111,
  author  = {Flicker, C and Ferris, S H and Kalkstein, D and Serby, M},
  title   = {{A double-blind, placebo-controlled crossover study of ganglioside GM1 treatment for Alzheimer's disease}},
  journal = {The American journal of psychiatry},
  year    = {1994},
  doi     = {10.1176/ajp.151.1.126},
  pmid    = {8267111},
  url     = {https://doi.org/10.1176/ajp.151.1.126}
}

@article{wang2022-35320578,
  author  = {Wang, D. and Kowalewski, E. K. and Koch, G.},
  title   = {{Application of Meta-analysis to Evaluate Relationships Among ARIA-E Rate, Amyloid Reduction Rate, and Clinical Cognitive Response in Amyloid Therapeutic Clinical Trials for Early Alzheimer's Disease}},
  journal = {Therapeutic innovation \& regulatory science},
  year    = {2022},
  doi     = {10.1007/s43441-022-00390-4},
  pmid    = {35320578},
  url     = {https://doi.org/10.1007/s43441-022-00390-4}
}

@article{raman2021-34228129,
  author  = {Raman, R. and Quiroz, Y. T. and Langford, O. and Choi, J. and Ritchie, M. and Baumgartner, M. and Rentz, D. and Aggarwal, N. T. and others},
  title   = {{Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial}},
  journal = {JAMA network open},
  year    = {2021},
  doi     = {10.1001/jamanetworkopen.2021.14364},
  pmid    = {34228129},
  url     = {https://doi.org/10.1001/jamanetworkopen.2021.14364}
}

@article{chou2017-28254448,
  author  = {Chou, P. S. and Ho, B. L. and Yang, Y. H.},
  title   = {{Effects of pioglitazone on the incidence of dementia in patients with diabetes}},
  journal = {Journal of diabetes and its complications},
  year    = {2017},
  doi     = {10.1016/j.jdiacomp.2017.01.006},
  pmid    = {28254448},
  url     = {https://doi.org/10.1016/j.jdiacomp.2017.01.006}
}

@article{nead2016-26644522,
  author  = {Nead, K. T. and Gaskin, G. and Chester, C. and Swisher-McClure, S. and Dudley, J. T. and Leeper, N. J. and Shah, N. H.},
  title   = {{Androgen Deprivation Therapy and Future Alzheimer's Disease Risk}},
  journal = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year    = {2016},
  doi     = {10.1200/jco.2015.63.6266},
  pmid    = {26644522},
  url     = {https://doi.org/10.1200/jco.2015.63.6266}
}

@article{fonsecasantos2015-26345528,
  author  = {Fonseca-Santos, B. and Gremião, M. P. and Chorilli, M.},
  title   = {{Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease}},
  journal = {International journal of nanomedicine},
  year    = {2015},
  doi     = {10.2147/ijn.s87148},
  pmid    = {26345528},
  url     = {https://doi.org/10.2147/ijn.s87148}
}

@article{richardson2013-24247674,
  author  = {Richardson, K. and Schoen, M. and French, B. and Umscheid, C. A. and Mitchell, M. D. and Arnold, S. E. and Heidenreich, P. A. and Rader, D. J. and others},
  title   = {{Statins and cognitive function: a systematic review}},
  journal = {Annals of internal medicine},
  year    = {2013},
  doi     = {10.7326/0003-4819-159-10-201311190-00007},
  pmid    = {24247674},
  url     = {https://doi.org/10.7326/0003-4819-159-10-201311190-00007}
}

@article{howard2012-22397651,
  author  = {Howard, R. and McShane, R. and Lindesay, J. and Ritchie, C. and Baldwin, A. and Barber, R. and Burns, A. and Dening, T. and others},
  title   = {{Donepezil and memantine for moderate-to-severe Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2012},
  doi     = {10.1056/nejmoa1106668},
  pmid    = {22397651},
  url     = {https://doi.org/10.1056/nejmoa1106668}
}

@article{kales2011-22193526,
  author  = {Kales, Helen C. and Kim, Hyungjin Myra and Zivin, Kara and Valenstein, Marcia M. and Seyfried, Lisa S. and Chiang, Claire and Cunningham, Francesca E. and Schneider, Lon S. S. and others},
  title   = {{Risk of Mortality Among Individual Antipsychotics in Patients With Dementia}},
  journal = {American Journal of Psychiatry},
  year    = {2011},
  doi     = {10.1176/appi.ajp.2011.11030347},
  pmid    = {22193526},
  url     = {https://doi.org/10.1176/appi.ajp.2011.11030347}
}

@article{kaduszkiewicz2005-16081444,
  author  = {Kaduszkiewicz, H. and Zimmermann, T. and Beck-Bornholdt, H. P. and van den Bussche, H.},
  title   = {{Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2005},
  doi     = {10.1136/bmj.331.7512.321},
  pmid    = {16081444},
  url     = {https://doi.org/10.1136/bmj.331.7512.321}
}

@article{barrettconnor1991-1872493,
  author  = {Barrett-Connor, Elizabeth L.},
  title   = {{Postmenopausal Estrogen and Prevention Bias}},
  journal = {Annals of Internal Medicine},
  year    = {1991},
  doi     = {10.7326/0003-4819-115-6-455},
  pmid    = {1872493},
  url     = {https://doi.org/10.7326/0003-4819-115-6-455}
}

@article{kang2026-42642841,
  author  = {Kang, Heekyoung and Jang, Hyemin and Ahn, Jehyun and Na, Duk L and Lee, Jae-Hong and Kim, Eun-Joo and Chun, Min Young and Cho, Soo Hyun and others},
  title   = {{APOE-guided lecanemab dosing dissociates ARIA-E from ARIA-H: The K-ROAD study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71765},
  pmid    = {42642841},
  url     = {https://doi.org/10.1002/alz.71765}
}

@article{agosta2026-41857623,
  author  = {Agosta, Federica and Cecchetti, Giordano and Spinelli, Edoardo G and Ghirelli, Alma and Rugarli, Giulia and Pisano, Stefano and Coraglia, Federico and Canu, Elisa and others},
  title   = {{Real-world implementation of lecanemab and donanemab in an Italian memory center: a 1-year experience}},
  journal = {Alzheimer's research \& therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-02015-6},
  pmid    = {41857623},
  url     = {https://doi.org/10.1186/s13195-026-02015-6}
}

@article{ashmawy2025-40232258,
  author  = {Ashmawy, R. E. and Okesanya, O. J. and Ukoaka, B. M. and Daniel, F. M. and Ezedigwe, S. G. and Agboola, A. O. and Ahmed, M. M. and Ogaya, J. B. and others},
  title   = {{Exploring the efficacy and safety of lecanemab in the management of early Alzheimer's disease: A systematic review of clinical evidence}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877251331640},
  pmid    = {40232258},
  url     = {https://doi.org/10.1177/13872877251331640}
}

@article{hey2024-38902571,
  author  = {Hey, J. A. and Abushakra, S. and Blennow, K. and Reiman, E. M. and Hort, J. and Prins, N. D. and Sheardova, K. and Kesslak, P. and others},
  title   = {{Effects of Oral ALZ-801/Valiltramiprosate on Plasma Biomarkers, Brain Hippocampal Volume, and Cognition: Results of 2-Year Single-Arm, Open-Label, Phase 2 Trial in APOE4 Carriers with Early Alzheimer's Disease}},
  journal = {Drugs},
  year    = {2024},
  doi     = {10.1007/s40265-024-02067-8},
  pmid    = {38902571},
  url     = {https://doi.org/10.1007/s40265-024-02067-8}
}

@article{foroutan2019-30904037,
  author  = {Foroutan, N. and Hopkins, R. B. and Tarride, J. E. and Florez, I. D. and Levine, M.},
  title   = {{Safety and efficacy of active and passive immunotherapy in mild-to-moderate Alzheimer's disease: A systematic review and network meta-analysis}},
  journal = {Clinical and investigative medicine. Medecine clinique et experimentale},
  year    = {2019},
  doi     = {10.25011/cim.v42i1.32393},
  pmid    = {30904037},
  url     = {https://doi.org/10.25011/cim.v42i1.32393}
}

@article{dyer2018-29143695,
  author  = {Dyer, S. M. and Harrison, S. L. and Laver, K. and Whitehead, C. and Crotty, M.},
  title   = {{An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia}},
  journal = {International psychogeriatrics},
  year    = {2018},
  doi     = {10.1017/s1041610217002344},
  pmid    = {29143695},
  url     = {https://doi.org/10.1017/s1041610217002344}
}

@article{geifman2017-28212683,
  author  = {Geifman, N. and Brinton, R. D. and Kennedy, R. E. and Schneider, L. S. and Butte, A. J.},
  title   = {{Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0237-y},
  pmid    = {28212683},
  url     = {https://doi.org/10.1186/s13195-017-0237-y}
}

@article{logovinsky2016-27048170,
  author  = {Logovinsky, V. and Satlin, A. and Lai, R. and Swanson, C. and Kaplow, J. and Osswald, G. and Basun, H. and Lannfelt, L.},
  title   = {{Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selective Aβ antibody}},
  journal = {Alzheimer's research \& therapy},
  year    = {2016},
  doi     = {10.1186/s13195-016-0181-2},
  pmid    = {27048170},
  url     = {https://doi.org/10.1186/s13195-016-0181-2}
}

@article{repantis2010-20193764,
  author  = {Repantis, Dimitris and Laisney, Oona and Heuser, Isabella},
  title   = {{Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review}},
  journal = {Pharmacological research},
  year    = {2010},
  doi     = {10.1016/j.phrs.2010.02.009},
  pmid    = {20193764},
  url     = {https://doi.org/10.1016/j.phrs.2010.02.009}
}

@article{prvulovic2010-20113148,
  author  = {Prvulovic, David and Hampel, Harald and Pantel, Johannes},
  title   = {{Galantamine for Alzheimer's disease}},
  journal = {Expert opinion on drug metabolism \& toxicology},
  year    = {2010},
  doi     = {10.1517/17425251003592137},
  pmid    = {20113148},
  url     = {https://doi.org/10.1517/17425251003592137}
}

@article{rodda2009-19538824,
  author  = {Rodda, Joanne and Morgan, Shirlony and Walker, Zuzana},
  title   = {{Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine}},
  journal = {International psychogeriatrics},
  year    = {2009},
  doi     = {10.1017/s1041610209990354},
  pmid    = {19538824},
  url     = {https://doi.org/10.1017/s1041610209990354}
}

@article{bhasin2007-17265415,
  author  = {Bhasin, Mani and Rowan, Elise and Edwards, Keith and McKeith, Ian},
  title   = {{Cholinesterase inhibitors in dementia with Lewy bodies: a comparative analysis}},
  journal = {International journal of geriatric psychiatry},
  year    = {2007},
  doi     = {10.1002/gps.1759},
  pmid    = {17265415},
  url     = {https://doi.org/10.1002/gps.1759}
}

@article{doody2001-11255446,
  author  = {Doody, R. S. and Geldmacher, D. S. and Gordon, B. and Perdomo, C. A. and Pratt, R. D. and {Donepezil Study Group}},
  title   = {{Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2001},
  doi     = {10.1001/archneur.58.3.427},
  pmid    = {11255446},
  url     = {https://doi.org/10.1001/archneur.58.3.427}
}

@article{ray1987-2880292,
  author  = {Ray, W. A. and Griffin, M. R. and Schaffner, W. and Baugh, D. K. and Melton, L. J.},
  title   = {{Psychotropic drug use and the risk of hip fracture}},
  journal = {The New England journal of medicine},
  year    = {1987},
  doi     = {10.1056/nejm198702123160702},
  pmid    = {2880292},
  url     = {https://doi.org/10.1056/nejm198702123160702}
}

@article{mintun2023-3d9d0576,
  author  = {Mintun, Mark A. and Ritchie, Craig William and Solomon, Paul R. and Sims, John Randall and Salloway, Stephen and Hansson, Oskar and Apostolova, Liana G. and Zimmer, Jennifer A. and others},
  title   = {{Donanemab in Early Symptomatic Alzheimer’s Disease: Efficacy and Safety in TRAILBLAZER‐ALZ 2, a Phase 3 Randomized Clinical Trial}},
  journal = {Alzheimer s \& Dementia},
  year    = {2023},
  doi     = {10.1002/alz.082733},
  url     = {https://doi.org/10.1002/alz.082733}
}

@article{branigan2020-32207833,
  author  = {Branigan, G. L. and Soto, M. and Neumayer, L. and Rodgers, K. and Brinton, R. D.},
  title   = {{Association Between Hormone-Modulating Breast Cancer Therapies and Incidence of Neurodegenerative Outcomes for Women With Breast Cancer}},
  journal = {JAMA network open},
  year    = {2020},
  doi     = {10.1001/jamanetworkopen.2020.1541},
  pmid    = {32207833},
  url     = {https://doi.org/10.1001/jamanetworkopen.2020.1541}
}

@article{yeh2019-31075943,
  author  = {Yeh, Liang-Tsai and Tang, Chuan-Yi and Yang, Shun-Fa and Yeh, Han-Wei and Yeh, Ying-Tung and Wang, Yu-Hsun and Chou, Ming-Chih and Yeh, Chao-Bin and others},
  title   = {{Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study}},
  journal = {International journal of environmental research and public health},
  year    = {2019},
  doi     = {10.3390/ijerph16091626},
  pmid    = {31075943},
  url     = {https://doi.org/10.3390/ijerph16091626}
}

@article{saito2016-29067312,
  author  = {Saito, Satoshi and Kojima, Shinsuke and Oishi, Naoya and Kakuta, Ryosuke and Maki, Takakuni and Yasuno, Fumihiko and Nagatsuka, Kazuyuki and Yamamoto, Haruko and others},
  title   = {{A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2016},
  doi     = {10.1016/j.trci.2016.10.001},
  pmid    = {29067312},
  url     = {https://doi.org/10.1016/j.trci.2016.10.001}
}

@article{chen2016-26918649,
  author  = {Chen, Yu-dan and Zhang, Juan and Wang, Yue and Yuan, Jun-liang and Hu, Wen-li},
  title   = {{Efficacy of Cholinesterase Inhibitors in Vascular Dementia: An Updated Meta-Analysis}},
  journal = {European neurology},
  year    = {2016},
  doi     = {10.1159/000444253},
  pmid    = {26918649},
  url     = {https://doi.org/10.1159/000444253}
}

@article{deardorff2015-26033268,
  author  = {Deardorff, W. J. and Feen, E. and Grossberg, G. T.},
  title   = {{The Use of Cholinesterase Inhibitors Across All Stages of Alzheimer's Disease}},
  journal = {Drugs \& aging},
  year    = {2015},
  doi     = {10.1007/s40266-015-0273-x},
  pmid    = {26033268},
  url     = {https://doi.org/10.1007/s40266-015-0273-x}
}

@article{poon2015-a031a0f8,
  author  = {Poon, Wai and Vos, Pieter and Muresanu, Dafin and Vester, Johannes and von Wild, Klaus and Hömberg, Volker and Wang, Ernest and Lee, Tatia M.C. and others},
  title   = {{Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery: Design and Methods}},
  journal = {Journal of Neurotrauma},
  year    = {2015},
  doi     = {10.1089/neu.2014.3558},
  url     = {https://doi.org/10.1089/neu.2014.3558}
}

@article{corbett2012-23123941,
  author  = {Corbett, A. and Pickett, J. and Burns, A. and Corcoran, J. and Dunnett, S. B. and Edison, P. and Hagan, J. J. and Holmes, C. and others},
  title   = {{Drug repositioning for Alzheimer's disease}},
  journal = {Nature reviews. Drug discovery},
  year    = {2012},
  doi     = {10.1038/nrd3869},
  pmid    = {23123941},
  url     = {https://doi.org/10.1038/nrd3869}
}

@article{kessing2008-18981345,
  author  = {Kessing, L. V. and Søndergård, L. and Forman, J. L. and Andersen, P. K.},
  title   = {{Lithium treatment and risk of dementia}},
  journal = {Archives of general psychiatry},
  year    = {2008},
  doi     = {10.1001/archpsyc.65.11.1331},
  pmid    = {18981345},
  url     = {https://doi.org/10.1001/archpsyc.65.11.1331}
}

@article{hansen2008-18686744,
  author  = {Hansen, R. A. and Gartlehner, G. and Webb, A. P. and Morgan, L. C. and Moore, C. G. and Jonas, D. E.},
  title   = {{Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis}},
  journal = {Clinical interventions in aging},
  year    = {2008},
  pmid    = {18686744}
}

@article{dunbar2007-17225162,
  author  = {Dunbar, G. and Boeijinga, P. H. and Demazières, A. and Cisterni, C. and Kuchibhatla, R. and Wesnes, K. and Luthringer, R.},
  title   = {{Effects of TC-1734 (AZD3480), a selective neuronal nicotinic receptor agonist, on cognitive performance and the EEG of young healthy male volunteers}},
  journal = {Psychopharmacology},
  year    = {2007},
  doi     = {10.1007/s00213-006-0675-x},
  pmid    = {17225162},
  url     = {https://doi.org/10.1007/s00213-006-0675-x}
}

@article{robinson2006-16906789,
  author  = {Robinson, D. M. and Keating, G. M.},
  title   = {{Memantine: a review of its use in Alzheimer's disease}},
  journal = {Drugs},
  year    = {2006},
  doi     = {10.2165/00003495-200666110-00015},
  pmid    = {16906789},
  url     = {https://doi.org/10.2165/00003495-200666110-00015}
}

@article{mauskopf2005-15804207,
  author  = {Mauskopf, J. A. and Paramore, C. and Lee, W. C. and Snyder, E. H.},
  title   = {{Drug persistency patterns for patients treated with rivastigmine or donepezil in usual care settings}},
  journal = {Journal of managed care pharmacy : JMCP},
  year    = {2005},
  doi     = {10.18553/jmcp.2005.11.3.231},
  pmid    = {15804207},
  url     = {https://doi.org/10.18553/jmcp.2005.11.3.231}
}

@article{farlow2000-11096224,
  author  = {Farlow, M. and Anand, R. and Messina, J. and Hartman, R. and Veach, J.},
  title   = {{A 52-week study of the efficacy of rivastigmine in patients with mild to moderately severe Alzheimer's disease}},
  journal = {European neurology},
  year    = {2000},
  doi     = {10.1159/000008243},
  pmid    = {11096224},
  url     = {https://doi.org/10.1159/000008243}
}

@article{hogervorst2000-11113299,
  author  = {Hogervorst, E. and Williams, J. and Budge, M. and Riedel, W. and Jolles, J.},
  title   = {{The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis}},
  journal = {Neuroscience},
  year    = {2000},
  doi     = {10.1016/s0306-4522(00)00410-3},
  pmid    = {11113299},
  url     = {https://doi.org/10.1016/s0306-4522(00)00410-3}
}

@article{hakim2026-42661728,
  author  = {Hakim, Ryan and Harris, Kristofer and Merrill, Livia and Falk-Vargas, Amanda and Whalen, Eileen and Xia, Tianxu and Ochoa, Olga and Hunter, David and others},
  title   = {{Real-world evidence for amyloid-targeted therapies: Lecanemab and donanemab}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2026},
  doi     = {10.1002/dad2.70404},
  pmid    = {42661728},
  url     = {https://doi.org/10.1002/dad2.70404}
}

@article{kim2025-41025359,
  author  = {Kim, JinWoo},
  title   = {{Glucagon-like peptide-1 receptor agonists and mental health: a narrative review of emerging benefits and risks}},
  journal = {Journal of Yeungnam medical science},
  year    = {2025},
  doi     = {10.12701/jyms.2025.42.61},
  pmid    = {41025359},
  url     = {https://doi.org/10.12701/jyms.2025.42.61}
}

@article{hong2024-39186787,
  author  = {Hong, Bin and Bea, Sungho and Ko, Hwa Yeon and Kim, Woo Jung and Cho, Young Min and Shin, Ju-Young},
  title   = {{Sodium-Glucose Cotransporter-2 Inhibitors, Dulaglutide, and Risk for Dementia : A Population-Based Cohort Study}},
  journal = {Annals of internal medicine},
  year    = {2024},
  doi     = {10.7326/m23-3220},
  pmid    = {39186787},
  url     = {https://doi.org/10.7326/m23-3220}
}

@article{aderinto2024-38725077,
  author  = {Aderinto, Nicholas and Olatunji, Gbolahan and Kokori, Emmanuel and Fawehinmi, Praise and Moradeyo, Abdulrahmon and Igwe, Stephen and Ojabo, Rebecca and Alabi, Badrudeen Olalekan and others},
  title   = {{Metformin mitigates dementia risk among individuals with type 2 diabetes}},
  journal = {Clinical diabetes and endocrinology},
  year    = {2024},
  doi     = {10.1186/s40842-024-00168-7},
  pmid    = {38725077},
  url     = {https://doi.org/10.1186/s40842-024-00168-7}
}

@article{lin2019-31106076,
  author  = {Lin, Yi-Ting and Chou, Mei-Chuan and Wu, Shyh-Jong and Yang, Yuan-Han},
  title   = {{Galantamine plasma concentration and cognitive response in Alzheimer's disease}},
  journal = {PeerJ},
  year    = {2019},
  doi     = {10.7717/peerj.6887},
  pmid    = {31106076},
  url     = {https://doi.org/10.7717/peerj.6887}
}

@article{tang2024-39429814,
  author  = {Tang, Bowen and Sjölander, Arvid and Wastesson, Jonas W. and Maura, Géric and Blotière, Pierre‐Olivier and Szilcz, Máté and Mak, Jonathan K. L. and Qin, Chenxi and others},
  title   = {{Comparative effectiveness of glucagon-like peptide-1 agonists, dipeptidyl peptidase-4 inhibitors, and sulfonylureas on the risk of dementia in older individuals with type 2 diabetes in Sweden: an emulated trial study}},
  journal = {EClinicalMedicine},
  year    = {2024},
  doi     = {10.1016/j.eclinm.2024.102689},
  pmid    = {39429814},
  url     = {https://doi.org/10.1016/j.eclinm.2024.102689}
}

@article{salloway2023-7521651f,
  author  = {Salloway, Stephen and Lee, Elly and Papka, Michelle and Pain, Andrew and Oru, Ena and Ferguson, Margaret B. and Wang, Hong and Case, Michael G. and others},
  title   = {{TRAILBLAZER-ALZ 4: Topline Study Results Directly Comparing Donanemab to Aducanumab on Amyloid Lowering in Early, Symptomatic Alzheimer's Disease}},
  journal = {BJPsych Open},
  year    = {2023},
  doi     = {10.1192/bjo.2023.227},
  url     = {https://doi.org/10.1192/bjo.2023.227}
}

@article{kalarus2022-36256580,
  author  = {Kalarus, Zbigniew F. and Mairesse, Georges H. and Sokal, Adam and Boriani, Giuseppe and Średniawa, Beata and Casado-Arroyo, Rubén and Wachter, Rolf and Frommeyer, Gerrit and others},
  title   = {{Searching for atrial fibrillation: looking harder, looking longer, and in increasingly sophisticated ways. An EHRA position paper}},
  journal = {EP Europace},
  year    = {2022},
  doi     = {10.1093/europace/euac144},
  pmid    = {36256580},
  url     = {https://doi.org/10.1093/europace/euac144}
}

@article{guthrie2020-32568196,
  author  = {Guthrie, H. and Honig, L. S. and Lin, H. and Sink, K. M. and Blondeau, K. and Quartino, A. and Dolton, M. and Carrasco-Triguero, M. and others},
  title   = {{Safety, Tolerability, and Pharmacokinetics of Crenezumab in Patients with Mild-to-Moderate Alzheimer's Disease Treated with Escalating Doses for up to 133 Weeks}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200134},
  pmid    = {32568196},
  url     = {https://doi.org/10.3233/jad-200134}
}

@article{carlson2016-27239538,
  author  = {Carlson, C. and Siemers, E. and Hake, A. and Case, M. and Hayduk, R. and Suhy, J. and Oh, J. and Barakos, J.},
  title   = {{Amyloid-related imaging abnormalities from trials of solanezumab for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2016},
  doi     = {10.1016/j.dadm.2016.02.004},
  pmid    = {27239538},
  url     = {https://doi.org/10.1016/j.dadm.2016.02.004}
}

@article{nunes2013-22746245,
  author  = {Nunes, M. A. and Viel, T. A. and Buck, H. S.},
  title   = {{Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease}},
  journal = {Current Alzheimer research},
  year    = {2013},
  doi     = {10.2174/1567205011310010014},
  pmid    = {22746245},
  url     = {https://doi.org/10.2174/1567205011310010014}
}

@article{haag2009-18931004,
  author  = {Haag, M. D. and Hofman, A. and Koudstaal, P. J. and Stricker, B. H. and Breteler, M. M.},
  title   = {{Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2009},
  doi     = {10.1136/jnnp.2008.150433},
  pmid    = {18931004},
  url     = {https://doi.org/10.1136/jnnp.2008.150433}
}

@article{rea2005-16009757,
  author  = {Rea, T. D. and Breitner, J. C. and Psaty, B. M. and Fitzpatrick, A. L. and Lopez, O. L. and Newman, A. B. and Hazzard, W. R. and Zandi, P. P. and others},
  title   = {{Statin use and the risk of incident dementia: the Cardiovascular Health Study}},
  journal = {Archives of neurology},
  year    = {2005},
  doi     = {10.1001/archneur.62.7.1047},
  pmid    = {16009757},
  url     = {https://doi.org/10.1001/archneur.62.7.1047}
}

@article{schneider1990-1970586,
  author  = {Schneider, L. S. and Pollock, V. E. and Lyness, S. A.},
  title   = {{A metaanalysis of controlled trials of neuroleptic treatment in dementia}},
  journal = {Journal of the American Geriatrics Society},
  year    = {1990},
  doi     = {10.1111/j.1532-5415.1990.tb02407.x},
  pmid    = {1970586},
  url     = {https://doi.org/10.1111/j.1532-5415.1990.tb02407.x}
}

@article{jeon2025-41225766,
  author  = {Jeon, So Yeon and Byun, Min Soo and Choi, Hye Ji and Kim, Yoon Hee and Gwag, Chung Hee and Oh, Yoonseok and Park, Jee Eun and Yi, Dahyun and others},
  title   = {{Eligibility for lecanemab and donanemab in Korea under Appropriate Use Recommendations}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70875},
  pmid    = {41225766},
  url     = {https://doi.org/10.1002/alz.70875}
}

@article{liu2025-40064559,
  author  = {Liu, Dongming and Cao, Hongbao and Baranova, Ancha and Xu, Chenxin and Zhang, Fuquan},
  title   = {{Opposite causal effects of type 2 diabetes and metformin on Alzheimer's disease}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100129},
  pmid    = {40064559},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100129}
}

@article{lam2022-35190446,
  author  = {Lam, Virginie and Clarnette, Roger and Francis, Roslyn and Bynevelt, Michael and Watts, Gerald and Flicker, Leon and Orr, Carolyn F and Loh, Poh and others},
  title   = {{Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study)}},
  journal = {BMJ open},
  year    = {2022},
  doi     = {10.1136/bmjopen-2021-058826},
  pmid    = {35190446},
  url     = {https://doi.org/10.1136/bmjopen-2021-058826}
}

@article{kloft2021-34946404,
  author  = {Kloft, Charlotte and Hoerr, Robert},
  title   = {{EGb 761® Does Not Affect Blood Coagulation and Bleeding Time in Patients with Probable Alzheimer's Dementia-Secondary Analysis of a Randomized, Double-Blind Placebo-Controlled Trial}},
  journal = {Healthcare (Basel, Switzerland)},
  year    = {2021},
  doi     = {10.3390/healthcare9121678},
  pmid    = {34946404},
  url     = {https://doi.org/10.3390/healthcare9121678}
}

@article{youn2021-33685036,
  author  = {Youn, HyunChul and Lee, Kang Joon and Kim, Shin-Gyeom and Cho, Seong-Jin and Kim, Woo Jung and Lee, Won Joon and Hwang, Jae Yeon and Han, Changsu and others},
  title   = {{The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer's Dementia: A Double-Blind Randomized Placebo-Controlled Trial}},
  journal = {Psychiatry investigation},
  year    = {2021},
  doi     = {10.30773/pi.2020.0329},
  pmid    = {33685036},
  url     = {https://doi.org/10.30773/pi.2020.0329}
}

@article{saintpaul2015-27393634,
  author  = {Saint-Paul, Laure Peyro and Martin, Jocelyne and Gaillard, Cathy and Garnier, Aline and Mosquet, Brigitte and Guillamo, Jean-Sébastien and Parienti, Jean-Jacques},
  title   = {{[Not Available]}},
  journal = {Therapie},
  year    = {2015},
  doi     = {10.2515/therapie/2014217},
  pmid    = {27393634},
  url     = {https://doi.org/10.2515/therapie/2014217}
}

@article{cummings2020-32695874,
  author  = {Cummings, J. and Lee, G. and Ritter, A. and Sabbagh, M. and Zhong, K.},
  title   = {{Alzheimer's disease drug development pipeline: 2020}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2020},
  doi     = {10.1002/trc2.12050},
  pmid    = {32695874},
  url     = {https://doi.org/10.1002/trc2.12050}
}

@article{wiumandersen2019-31437816,
  author  = {Wium-Andersen, I. K. and Osler, M. and Jørgensen, M. B. and Rungby, J. and Wium-Andersen, M. K.},
  title   = {{Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case-control study}},
  journal = {European journal of endocrinology},
  year    = {2019},
  doi     = {10.1530/eje-19-0259},
  pmid    = {31437816},
  url     = {https://doi.org/10.1530/eje-19-0259}
}

@article{kong2025-40520157,
  author  = {Kong, L. and Yang, X. and Xu, J.},
  title   = {{Comparison of safety of lecanemab and aducanumab: a real-world disproportionality analysis using the FDA adverse event reporting system}},
  journal = {Frontiers in pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1593989},
  pmid    = {40520157},
  url     = {https://doi.org/10.3389/fphar.2025.1593989}
}

@article{xing2025-39780222,
  author  = {Xing, X. and Zhang, X. and Wang, K. and Wang, Z. and Feng, Y. and Li, X. and Hua, Y. and Zhang, L. and others},
  title   = {{Post-marketing safety concerns with lecanemab: a pharmacovigilance study based on the FDA Adverse Event Reporting System database}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-024-01669-4},
  pmid    = {39780222},
  url     = {https://doi.org/10.1186/s13195-024-01669-4}
}

@article{holper2023-37874102,
  author  = {Holper, S and Watson, R and Churilov, L and Yates, P and Lim, Y Y and Barnham, K J and Yassi, N},
  title   = {{Protocol of a Phase II Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial of S-Adenosyl Methionine in Participants with Mild Cognitive Impairment or Dementia Due to Alzheimer's Disease}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2023},
  doi     = {10.14283/jpad.2023.55},
  pmid    = {37874102},
  url     = {https://doi.org/10.14283/jpad.2023.55}
}

@article{liu2022-35101059,
  author  = {Liu, Qiang and Vaci, Nemanja and Koychev, Ivan and Kormilitzin, Andrey and Li, Zhenpeng and Cipriani, Andrea and Nevado-Holgado, Alejo},
  title   = {{Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model}},
  journal = {BMC medicine},
  year    = {2022},
  doi     = {10.1186/s12916-022-02250-2},
  pmid    = {35101059},
  url     = {https://doi.org/10.1186/s12916-022-02250-2}
}

@article{mo2017-29296624,
  author  = {Mo, J. J. and Li, J. Y. and Yang, Z. and Liu, Z. and Feng, J. S.},
  title   = {{Efficacy and safety of anti-amyloid- β immunotherapy for Alzheimer's disease: a systematic review and network meta-analysis}},
  journal = {Annals of clinical and translational neurology},
  year    = {2017},
  doi     = {10.1002/acn3.469},
  pmid    = {29296624},
  url     = {https://doi.org/10.1002/acn3.469}
}

@article{farlow2015-25918556,
  author  = {Farlow, M. R. and Andreasen, N. and Riviere, M. E. and Vostiar, I. and Vitaliti, A. and Sovago, J. and Caputo, A. and Winblad, B. and others},
  title   = {{Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2015},
  doi     = {10.1186/s13195-015-0108-3},
  pmid    = {25918556},
  url     = {https://doi.org/10.1186/s13195-015-0108-3}
}

@article{lai2015-25912671,
  author  = {Lai, Edward Chia-Cheng and Wong, Monera B and Iwata, Isao and Zhang, Yinghong and Hsieh, Cheng-Yang and Yang, Yea-Huei Kao and Setoguchi, Soko},
  title   = {{Risk of pneumonia in new users of cholinesterase inhibitors for dementia}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2015},
  doi     = {10.1111/jgs.13380},
  pmid    = {25912671},
  url     = {https://doi.org/10.1111/jgs.13380}
}

@article{huybrechts2012-22362541,
  author  = {Huybrechts, K. F. and Gerhard, T. and Crystal, S. and Olfson, M. and Avorn, J. and Levin, R. and Lucas, J. A. and Schneeweiss, S.},
  title   = {{Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2012},
  doi     = {10.1136/bmj.e977},
  pmid    = {22362541},
  url     = {https://doi.org/10.1136/bmj.e977}
}

@article{wu2009-19546656,
  author  = {Wu, C. S. and Wang, S. C. and Chang, I. S. and Lin, K. M.},
  title   = {{The association between dementia and long-term use of benzodiazepine in the elderly: nested case-control study using claims data}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2009},
  doi     = {10.1097/jgp.0b013e3181a65210},
  pmid    = {19546656},
  url     = {https://doi.org/10.1097/jgp.0b013e3181a65210}
}

@article{shaw2006-16549835,
  author  = {Shaw, E. G. and Rosdhal, R. and D'Agostino, R. B. and Lovato, J. and Naughton, M. J. and Robbins, M. E. and Rapp, SR.},
  title   = {{Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life}},
  journal = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year    = {2006},
  doi     = {10.1200/jco.2005.03.3001},
  pmid    = {16549835},
  url     = {https://doi.org/10.1200/jco.2005.03.3001}
}

@article{lebars1997-f69c6c73,
  author  = {Le Bars, Pierre L.},
  title   = {{A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia}},
  journal = {JAMA},
  year    = {1997},
  doi     = {10.1001/jama.1997.03550160047037},
  url     = {https://doi.org/10.1001/jama.1997.03550160047037}
}

@article{kawas1997-9191758,
  author  = {Kawas, C. and Resnick, S. and Morrison, A. and Brookmeyer, R. and Corrada, M. and Zonderman, A. and Bacal, C. and Lingle, D. D. and others},
  title   = {{A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging}},
  journal = {Neurology},
  year    = {1997},
  doi     = {10.1212/wnl.48.6.1517},
  pmid    = {9191758},
  url     = {https://doi.org/10.1212/wnl.48.6.1517}
}

@article{henderson1994-8080389,
  author  = {Henderson, V. W. and Paganini-Hill, A. and Emanuel, C. K. and Dunn, M. E. and Buckwalter, J. G.},
  title   = {{Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects}},
  journal = {Archives of neurology},
  year    = {1994},
  doi     = {10.1001/archneur.1994.00540210068014},
  pmid    = {8080389},
  url     = {https://doi.org/10.1001/archneur.1994.00540210068014}
}

@article{mittler2025-40237866,
  author  = {Mittler, Brant and Cambi, Xavier and Biskach, Morgan and Reisman, Joel and Wang, Ying and Berlowitz, Dan and Morin, Peter and Miller, Donald R and others},
  title   = {{Patient journey and decision processes for anti-amyloid therapy in Alzheimer's disease}},
  journal = {Journal of neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13059-3},
  pmid    = {40237866},
  url     = {https://doi.org/10.1007/s00415-025-13059-3}
}

@article{cummings2022-35516416,
  author  = {Cummings, J. and Lee, G. and Nahed, P. and Kambar, M. E. Z. N. and Zhong, K. and Fonseca, J. and Taghva, K.},
  title   = {{Alzheimer's disease drug development pipeline: 2022}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12295},
  pmid    = {35516416},
  url     = {https://doi.org/10.1002/trc2.12295}
}

@article{villarreal2017-28800329,
  author  = {Villarreal, S. and Zhao, F. and Hyde, L. A. and Holder, D. and Forest, T. and Sondey, M. and Chen, X. and Sur, C. and others},
  title   = {{Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-170056},
  pmid    = {28800329},
  url     = {https://doi.org/10.3233/jad-170056}
}

@article{kalischellett2014-25284144,
  author  = {Kalisch Ellett, L. M. and Pratt, N. L. and Ramsay, E. N. and Barratt, J. D. and Roughead, E. E.},
  title   = {{Multiple anticholinergic medication use and risk of hospital admission for confusion or dementia}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2014},
  doi     = {10.1111/jgs.13054},
  pmid    = {25284144},
  url     = {https://doi.org/10.1111/jgs.13054}
}

@article{tan2014-24662102,
  author  = {Tan, C. C. and Yu, J. T. and Wang, H. F. and Tan, M. S. and Meng, X. F. and Wang, C. and Jiang, T. and Zhu, X. C. and others},
  title   = {{Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: a systematic review and meta-analysis}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-132690},
  pmid    = {24662102},
  url     = {https://doi.org/10.3233/jad-132690}
}

@article{henderson2009-19664276,
  author  = {Henderson, S. T. and Vogel, J. L. and Barr, L. J. and Garvin, F. and Jones, J. J. and Costantini, L. C.},
  title   = {{Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial}},
  journal = {Nutrition \& metabolism},
  year    = {2009},
  doi     = {10.1186/1743-7075-6-31},
  pmid    = {19664276},
  url     = {https://doi.org/10.1186/1743-7075-6-31}
}

@article{ravina2005-15965198,
  author  = {Ravina, Bernard M.},
  title   = {{Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study}},
  journal = {Journal of Neurology Neurosurgery \& Psychiatry},
  year    = {2005},
  doi     = {10.1136/jnnp.2004.050682},
  pmid    = {15965198},
  url     = {https://doi.org/10.1136/jnnp.2004.050682}
}

@article{ballard2005-15722369,
  author  = {Ballard, C. and Margallo-Lana, M. and Juszczak, E. and Douglas, S. and Swann, A. and Thomas, A. and O'Brien, J. and Everratt, A. and others},
  title   = {{Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randomised double blind placebo controlled trial}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2005},
  doi     = {10.1136/bmj.38369.459988.8f},
  pmid    = {15722369},
  url     = {https://doi.org/10.1136/bmj.38369.459988.8f}
}

@article{rosler1999-10066203,
  author  = {Rösler, M. and Anand, R. and Cicin-Sain, A. and Gauthier, S. and Agid, Y. and Dal-Bianco, P. and Stähelin, H. B. and Hartman, R. and others},
  title   = {{Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial}},
  journal = {BMJ (Clinical research ed.)},
  year    = {1999},
  doi     = {10.1136/bmj.318.7184.633},
  pmid    = {10066203},
  url     = {https://doi.org/10.1136/bmj.318.7184.633}
}

@article{singer2003-14655926,
  author  = {Singer, C. and Tractenberg, R. E. and Kaye, J. and Schafer, K. and Gamst, A. and Grundman, M. and Thomas, R. and Thal, L. J. and others},
  title   = {{A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease}},
  journal = {Sleep},
  year    = {2003},
  doi     = {10.1093/sleep/26.7.893},
  pmid    = {14655926},
  url     = {https://doi.org/10.1093/sleep/26.7.893}
}

@article{rockwood2001-11606667,
  author  = {Rockwood, K. and Mintzer, J. and Truyen, L. and Wessel, T. and Wilkinson, D.},
  title   = {{Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2001},
  doi     = {10.1136/jnnp.71.5.589},
  pmid    = {11606667},
  url     = {https://doi.org/10.1136/jnnp.71.5.589}
}

@article{majid2024-39207112,
  author  = {Majid, O. and Cao, Y. and Willis, B. A. and Hayato, S. and Takenaka, O. and Lalovic, B. and Sreerama Reddy, S. H. and Penner, N. and others},
  title   = {{Population pharmacokinetics and exposure-response analyses of safety (ARIA-E and isolated ARIA-H) of lecanemab in subjects with early Alzheimer's disease}},
  journal = {CPT: pharmacometrics \& systems pharmacology},
  year    = {2024},
  doi     = {10.1002/psp4.13224},
  pmid    = {39207112},
  url     = {https://doi.org/10.1002/psp4.13224}
}

@article{cummings2024-38659717,
  author  = {Cummings, J. and Zhou, Y. and Lee, G. and Zhong, K. and Fonseca, J. and Cheng, F.},
  title   = {{Alzheimer's disease drug development pipeline: 2024}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2024},
  doi     = {10.1002/trc2.12465},
  pmid    = {38659717},
  url     = {https://doi.org/10.1002/trc2.12465}
}

@article{gonzales2023-37679434,
  author  = {Gonzales, M. M. and Garbarino, V. R. and Kautz, T. F. and Palavicini, J. P. and Lopez-Cruzan, M. and Dehkordi, S. K. and Mathews, J. J. and Zare, H. and others},
  title   = {{Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial}},
  journal = {Nature medicine},
  year    = {2023},
  doi     = {10.1038/s41591-023-02543-w},
  pmid    = {37679434},
  url     = {https://doi.org/10.1038/s41591-023-02543-w}
}

@article{aldea2022-35676943,
  author  = {Aldea, R. and Grimm, H. P. and Gieschke, R. and Hofmann, C. and Lott, D. and Bullain, S. and Delmar, P. and Klein, G. and others},
  title   = {{In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12306},
  pmid    = {35676943},
  url     = {https://doi.org/10.1002/trc2.12306}
}

@article{byun2022-35292697,
  author  = {Byun, JungHyun and Lee, Dong Yun and Jeong, Chang-Won and Kim, Yerim and Rhee, Hak Young and Moon, Ki Won and Heo, Jeongwon and Hong, Yoonki and others},
  title   = {{Analysis of treatment pattern of anti-dementia medications in newly diagnosed Alzheimer's dementia using OMOP CDM}},
  journal = {Scientific reports},
  year    = {2022},
  doi     = {10.1038/s41598-022-08595-1},
  pmid    = {35292697},
  url     = {https://doi.org/10.1038/s41598-022-08595-1}
}

@article{maust2021-33687462,
  author  = {Maust, D. T. and Strominger, J. and Kim, H. M. and Langa, K. M. and Bynum, J. P. W. and Chang, C. H. and Kales, H. C. and Zivin, K. and others},
  title   = {{Prevalence of Central Nervous System-Active Polypharmacy Among Older Adults With Dementia in the US}},
  journal = {JAMA},
  year    = {2021},
  doi     = {10.1001/jama.2021.1195},
  pmid    = {33687462},
  url     = {https://doi.org/10.1001/jama.2021.1195}
}

@article{wandell2019-31349951,
  author  = {Wändell, Per and Carlsson, Axel C and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  title   = {{Association Between Relevant Co-Morbidities and Dementia With Atrial Fibrillation-A National Study}},
  journal = {Archives of medical research},
  year    = {2019},
  doi     = {10.1016/j.arcmed.2019.05.007},
  pmid    = {31349951},
  url     = {https://doi.org/10.1016/j.arcmed.2019.05.007}
}

@article{dasilva2019-30766470,
  author  = {Da Silva, Rose Mary Ferreira Lisboa and Miranda, Cláudia Madeira and Liu, Tong and Tse, Gary and Roever, Leonardo},
  title   = {{Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.00018},
  pmid    = {30766470},
  url     = {https://doi.org/10.3389/fnins.2019.00018}
}

@article{fisher2017-28138912,
  author  = {Fisher, Anat and Carney, Greg and Bassett, Ken and Dormuth, Colin R},
  title   = {{Tolerability of Cholinesterase Inhibitors: A Population-Based Study of Persistence, Adherence, and Switching}},
  journal = {Drugs \& aging},
  year    = {2017},
  doi     = {10.1007/s40266-017-0438-x},
  pmid    = {28138912},
  url     = {https://doi.org/10.1007/s40266-017-0438-x}
}

@article{zissimopoulos2017-27942728,
  author  = {Zissimopoulos, J. M. and Barthold, D. and Brinton, R. D. and Joyce, G.},
  title   = {{Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.3783},
  pmid    = {27942728},
  url     = {https://doi.org/10.1001/jamaneurol.2016.3783}
}

@article{iranzo2016-26971662,
  author  = {Iranzo, A. and Santamaria, J. and Tolosa, E.},
  title   = {{Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions}},
  journal = {The Lancet. Neurology},
  year    = {2016},
  doi     = {10.1016/s1474-4422(16)00057-0},
  pmid    = {26971662},
  url     = {https://doi.org/10.1016/s1474-4422(16)00057-0}
}

@article{lasser2015-f0473682,
  author  = {Lasser, Robert A. and Ostrowitzki, Susanne and Scheltens, Philip and Boada, Merçé and Dubois, Bruno and Dorflinger, Ernest E. and Balas, Bogdan and Nikolcheva, Tania and others},
  title   = {{DT‐01‐03: Efficacy and safety of gantenerumab in prodromal Alzheimer's disease: Results from scarlet road—a global, multicenter trial}},
  journal = {Alzheimer s \& Dementia},
  year    = {2015},
  doi     = {10.1016/j.jalz.2015.08.153},
  url     = {https://doi.org/10.1016/j.jalz.2015.08.153}
}

@article{cummings2014-a7c335d7,
  author  = {Cummings, Jeffrey L. and Cho, William and Ward, Michael Emmerson and Friesenhahn, Michel J. and Brunstein, Flávia and Honigberg, Lee A. and Clayton, David and Mortensen, Deborah L. and others},
  title   = {{O4‐11‐06: A RANDOMIZED, DOUBLE‐BLIND, PLACEBO‐CONTROLLED PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CRENEZUMAB IN PATIENTS WITH MILD TO MODERATE ALZHEIMER'S DISEASE}},
  journal = {Alzheimer s \& Dementia},
  year    = {2014},
  doi     = {10.1016/j.jalz.2014.04.450},
  url     = {https://doi.org/10.1016/j.jalz.2014.04.450}
}

@article{brewer2013-23443628,
  author  = {Brewer, Linda and Bennett, Kathleen and McGreevy, Cora and Williams, David},
  title   = {{A population-based study of dosing and persistence with anti-dementia medications}},
  journal = {European journal of clinical pharmacology},
  year    = {2013},
  doi     = {10.1007/s00228-013-1483-y},
  pmid    = {23443628},
  url     = {https://doi.org/10.1007/s00228-013-1483-y}
}

@article{gauthier2002-12670060,
  author  = {Gauthier, Serge G. and Feldman, Howard and Hecker, Jane R and Vellas, Bruno J. and Ames, David J. and Subbiah, Ponni and Whalen, Edward and Emir, Birol},
  title   = {{Efficacy of Donepezil on Behavioral Symptoms in Patients With Moderate to Severe Alzheimer’s Disease}},
  journal = {International Psychogeriatrics},
  year    = {2002},
  doi     = {10.1017/s104161020200858x},
  pmid    = {12670060},
  url     = {https://doi.org/10.1017/s104161020200858x}
}

@article{scharf1999-10408559,
  author  = {Scharf, Simon and Mander, Alastair G. and Ugoni, A. and Vajda, Frank J.E. and Christophidis, N.},
  title   = {{A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease}},
  journal = {Neurology},
  year    = {1999},
  doi     = {10.1212/wnl.53.1.197},
  pmid    = {10408559},
  url     = {https://doi.org/10.1212/wnl.53.1.197}
}

@article{devanand1997-9075466,
  author  = {Devanand, Davangere P.},
  title   = {{The Course of Psychopathologic Features in Mild to Moderate Alzheimer Disease}},
  journal = {Archives of General Psychiatry},
  year    = {1997},
  doi     = {10.1001/archpsyc.1997.01830150083012},
  pmid    = {9075466},
  url     = {https://doi.org/10.1001/archpsyc.1997.01830150083012}
}

@article{andersen1995-7644037,
  author  = {Andersen, K. and Launer, L. J. and Ott, A. and Hoes, A. W. and Breteler, M. M. and Hofman, A.},
  title   = {{Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study}},
  journal = {Neurology},
  year    = {1995},
  doi     = {10.1212/wnl.45.8.1441},
  pmid    = {7644037},
  url     = {https://doi.org/10.1212/wnl.45.8.1441}
}

@article{ray1989-2573741,
  author  = {Ray, W. A. and Griffin, M. R. and Downey, W.},
  title   = {{Benzodiazepines of long and short elimination half-life and the risk of hip fracture}},
  journal = {JAMA},
  year    = {1989},
  doi     = {10.1001/jama.1989.03430230088031},
  pmid    = {2573741},
  url     = {https://doi.org/10.1001/jama.1989.03430230088031}
}

@article{zhang2025-40898408,
  author  = {Zhang, Pengyue and Mao, Chengsheng and Sun, Anna and Yang, Yuedi and Hou, Yuan and Fu, Zhimin and Babak, Tousi and Leverenz, James B and others},
  title   = {{Real-world observations of GLP-1 receptor agonists and SGLT-2 inhibitors as potential treatments for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70639},
  pmid    = {40898408},
  url     = {https://doi.org/10.1002/alz.70639}
}

@article{rissardo2025-40224553,
  author  = {Rissardo, Jamir Pitton and Caprara, Ana Letícia Fornari},
  title   = {{Movement disorders associated with acetylcholinesterase inhibitors in Alzheimer's dementia: A systematic review}},
  journal = {Brain circulation},
  year    = {2025},
  doi     = {10.4103/bc.bc_134_24},
  pmid    = {40224553},
  url     = {https://doi.org/10.4103/bc.bc_134_24}
}

@article{dominguez2024-39408386,
  author  = {Dominguez, Ligia J and Veronese, Nicola and Parisi, Angela and Seminara, Flavia and Vernuccio, Laura and Catanese, Giuseppina and Barbagallo, Mario},
  title   = {{Mediterranean Diet and Lifestyle in Persons with Mild to Moderate Alzheimer's Disease}},
  journal = {Nutrients},
  year    = {2024},
  doi     = {10.3390/nu16193421},
  pmid    = {39408386},
  url     = {https://doi.org/10.3390/nu16193421}
}

@article{possemis2024-38438923,
  author  = {Possemis, Nina and Verhey, Frans and Prickaerts, Jos and Blokland, Arjan and Ramakers, Inez},
  title   = {{A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer's disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial}},
  journal = {Trials},
  year    = {2024},
  doi     = {10.1186/s13063-024-08001-3},
  pmid    = {38438923},
  url     = {https://doi.org/10.1186/s13063-024-08001-3}
}

@article{wolters2024-38380503,
  author  = {Wolters, Frank J and Labrecque, Jeremy A},
  title   = {{Potential impact of unblinding on observed treatment effects in Alzheimer's disease trials}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13690},
  pmid    = {38380503},
  url     = {https://doi.org/10.1002/alz.13690}
}

@article{ramakrishnan2024-39350369,
  author  = {Ramakrishnan, V and Bender, B and Langenhorst, J and Magnusson, M O and Dolton, M and Shim, J and Fuji, R N and Monteiro, C and others},
  title   = {{Semorinemab Pharmacokinetics and The Effect on Plasma Total Tau Pharmacodynamics in Clinical Studies}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2024},
  doi     = {10.14283/jpad.2024.146},
  pmid    = {39350369},
  url     = {https://doi.org/10.14283/jpad.2024.146}
}

@article{sood2024-37931533,
  author  = {Sood, Ajay and Capuano, Ana Werneck and Wilson, Robert Smith and Barnes, Lisa Laverne and Kapasi, Alifiya and Bennett, David Alan and Arvanitakis, Zoe},
  title   = {{Metformin, age-related cognitive decline, and brain pathology}},
  journal = {Neurobiology of aging},
  year    = {2024},
  doi     = {10.1016/j.neurobiolaging.2023.10.005},
  pmid    = {37931533},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2023.10.005}
}

@article{jeong2022-35466102,
  author  = {Jeong, Hye Won and Yoon, Kyung Hee and Lee, Chang Hyun and Moon, Yoo Sun and Kim, Do Hoon},
  title   = {{Vortioxetine Treatment for Depression in Alzheimer's Disease: A Randomized, Double-blind, Placebo-controlled Study}},
  journal = {Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology},
  year    = {2022},
  doi     = {10.9758/cpn.2022.20.2.311},
  pmid    = {35466102},
  url     = {https://doi.org/10.9758/cpn.2022.20.2.311}
}

@article{welk2020-32167223,
  author  = {Welk, B. and McArthur, E.},
  title   = {{Increased risk of dementia among patients with overactive bladder treated with an anticholinergic medication compared to a beta-3 agonist: a population-based cohort study}},
  journal = {BJU international},
  year    = {2020},
  doi     = {10.1111/bju.15040},
  pmid    = {32167223},
  url     = {https://doi.org/10.1111/bju.15040}
}

@article{fisher2016-27565287,
  author  = {Fisher, Anat and Carney, Greg and Bassett, Ken and Chappell, Neena L},
  title   = {{Cholinesterase Inhibitor Utilization: The Impact of Provincial Drug Policy on Discontinuation}},
  journal = {Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research},
  year    = {2016},
  doi     = {10.1016/j.jval.2016.03.1832},
  pmid    = {27565287},
  url     = {https://doi.org/10.1016/j.jval.2016.03.1832}
}

@article{santoro2010-20088621,
  author  = {Santoro, Aurelia and Siviero, Paola and Minicuci, Nadia and Bellavista, Elena and Mishto, Michele and Olivieri, Fabiola and Marchegiani, Francesca and Chiamenti, Andrea Maria and others},
  title   = {{Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study}},
  journal = {CNS drugs},
  year    = {2010},
  doi     = {10.2165/11310960-000000000-00000},
  pmid    = {20088621},
  url     = {https://doi.org/10.2165/11310960-000000000-00000}
}

@article{davis1992-1406817,
  author  = {Davis, K. L. and Thal, L. J. and Gamzu, E. R. and Davis, C. S. and Woolson, R. F. and Gracon, S. I. and Drachman, D. A. and Schneider, L. S. and others},
  title   = {{A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group}},
  journal = {The New England journal of medicine},
  year    = {1992},
  doi     = {10.1056/nejm199210293271801},
  pmid    = {1406817},
  url     = {https://doi.org/10.1056/nejm199210293271801}
}

@article{yan2025-40242445,
  author  = {Yan, L. and Zhang, L. and Xu, Z. and Luo, Z.},
  title   = {{A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for lecanemab}},
  journal = {Frontiers in pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1559447},
  pmid    = {40242445},
  url     = {https://doi.org/10.3389/fphar.2025.1559447}
}

@article{gibson2024-39215494,
  author  = {Gibson, A. W. and Elser, H. and Rosso, M. and Cornblath, E. J. and Fonkeu, Y. and Prasad, S. and Rothstein, A. and Nasrallah, I. M. and others},
  title   = {{Ischemic stroke associated with amyloid-related imaging abnormalities in a patient treated with lecanemab}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14223},
  pmid    = {39215494},
  url     = {https://doi.org/10.1002/alz.14223}
}

@article{bracoud2023-38026755,
  author  = {Bracoud, L. and Klein, G. and Lyons, M. and Scelsi, M. A. and Wojtowicz, J. and Bullain, S. and Purcell, D. and Fiebach, J. B. and others},
  title   = {{Validation of 3- and 5-point severity scales to assess ARIA-E}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2023},
  doi     = {10.1002/dad2.12503},
  pmid    = {38026755},
  url     = {https://doi.org/10.1002/dad2.12503}
}

@article{aisen2022-35379951,
  author  = {Aisen, P. S. and Jimenez-Maggiora, G. A. and Rafii, M. S. and Walter, S. and Raman, R.},
  title   = {{Early-stage Alzheimer disease: getting trial-ready}},
  journal = {Nature reviews. Neurology},
  year    = {2022},
  doi     = {10.1038/s41582-022-00645-6},
  pmid    = {35379951},
  url     = {https://doi.org/10.1038/s41582-022-00645-6}
}

@article{edison2021-157ef668,
  author  = {Edison, Paul and Femminella, Grazia Daniela and Ritchie, Craig William and Holmes, Clive and Walker, Zuzana and Ridha, Basil H. and Raza, Sanara and Livingston, Nicholas R and others},
  title   = {{Evaluation of liraglutide in the treatment of Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2021},
  doi     = {10.1002/alz.057848},
  url     = {https://doi.org/10.1002/alz.057848}
}

@article{akimoto2020-32162525,
  author  = {Akimoto, H. and Negishi, A. and Oshima, S. and Wakiyama, H. and Okita, M. and Horii, N. and Inoue, N. and Ohshima, S. and others},
  title   = {{Antidiabetic Drugs for the Risk of Alzheimer Disease in Patients With Type 2 DM Using FAERS}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2020},
  doi     = {10.1177/1533317519899546},
  pmid    = {32162525},
  url     = {https://doi.org/10.1177/1533317519899546}
}

@article{ng2018-29720722,
  author  = {Ng, H. S. and Koczwara, B. and Roder, D. and Vitry, A.},
  title   = {{Development of comorbidities in men with prostate cancer treated with androgen deprivation therapy: an Australian population-based cohort study}},
  journal = {Prostate cancer and prostatic diseases},
  year    = {2018},
  doi     = {10.1038/s41391-018-0036-y},
  pmid    = {29720722},
  url     = {https://doi.org/10.1038/s41391-018-0036-y}
}

@article{depablofernandez2017-28655059,
  author  = {De Pablo-Fernandez, E. and Tur, C. and Revesz, T. and Lees, A. J. and Holton, J. L. and Warner, T. T.},
  title   = {{Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.1125},
  pmid    = {28655059},
  url     = {https://doi.org/10.1001/jamaneurol.2017.1125}
}

@article{ferrero2016-29067304,
  author  = {Ferrero, J. and Williams, L. and Stella, H. and Leitermann, K. and Mikulskis, A. and O'Gorman, J. and Sevigny, J.},
  title   = {{First-in-human, double-blind, placebo-controlled, single-dose escalation study of aducanumab (BIIB037) in mild-to-moderate Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2016},
  doi     = {10.1016/j.trci.2016.06.002},
  pmid    = {29067304},
  url     = {https://doi.org/10.1016/j.trci.2016.06.002}
}

@article{becker2008-18256367,
  author  = {Becker, C. and Jick, S. S. and Meier, C. R.},
  title   = {{Use of antihypertensives and the risk of Parkinson disease}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000303818.38960.44},
  pmid    = {18256367},
  url     = {https://doi.org/10.1212/01.wnl.0000303818.38960.44}
}

@article{gauthier2007-18058838,
  author  = {Gauthier, Serge G. and Loft, Henrik and Cummings, Jeffrey L.},
  title   = {{Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis}},
  journal = {International Journal of Geriatric Psychiatry},
  year    = {2007},
  doi     = {10.1002/gps.1949},
  pmid    = {18058838},
  url     = {https://doi.org/10.1002/gps.1949}
}

@article{li2007-17724290,
  author  = {Li, G. and Larson, E. B. and Sonnen, J. A. and Shofer, J. B. and Petrie, E. C. and Schantz, A. and Peskind, E. R. and Raskind, M. A. and others},
  title   = {{Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease}},
  journal = {Neurology},
  year    = {2007},
  doi     = {10.1212/01.wnl.0000277657.95487.1c},
  pmid    = {17724290},
  url     = {https://doi.org/10.1212/01.wnl.0000277657.95487.1c}
}

@article{study2005-15968015,
  author  = {{NIH State-of-the-Science Panel}},
  title   = {{National Institutes of Health State-of-the-Science Conference Statement: Management of Menopause-Related Symptoms}},
  journal = {Annals of Internal Medicine},
  year    = {2005},
  doi     = {10.7326/0003-4819-142-12_part_1-200506210-00117},
  pmid    = {15968015},
  url     = {https://doi.org/10.7326/0003-4819-142-12_part_1-200506210-00117}
}

@article{neumann1999-10214734,
  author  = {Neumann, P. J. and Hermann, R. C. and Kuntz, K. M. and Araki, S. S. and Duff, S. B. and Leon, J. and Berenbaum, P. A. and Goldman, P. A. and others},
  title   = {{Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's disease}},
  journal = {Neurology},
  year    = {1999},
  doi     = {10.1212/wnl.52.6.1138},
  pmid    = {10214734},
  url     = {https://doi.org/10.1212/wnl.52.6.1138}
}

@article{jiang2026-41694525,
  author  = {Jiang, Xiangxiang and Lv, Gang and Mendes, Morgan E and Wu, Jun and Yuan, Jing and Lu, Z Kevin},
  title   = {{Lifetime cost-effectiveness of lecanemab for early Alzheimer's disease}},
  journal = {Frontiers in public health},
  year    = {2026},
  doi     = {10.3389/fpubh.2026.1692508},
  pmid    = {41694525},
  url     = {https://doi.org/10.3389/fpubh.2026.1692508}
}

@article{heo2025-40687401,
  author  = {Heo, Rachel J and Negida, Ahmed and Wyman-Chick, Kathryn A and Bateman, James R and Rodriguez-Porcel, Federico and Berman, Brian D and Mukhopadhyay, Nitai and Barrett, Matthew J},
  title   = {{Patterns and predictors of cholinesterase inhibitor use in dementia with Lewy bodies}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2025},
  doi     = {10.1002/trc2.70136},
  pmid    = {40687401},
  url     = {https://doi.org/10.1002/trc2.70136}
}

@article{shields2024-39559868,
  author  = {Shields, L. B. E. and Hust, H. and Cooley, S. D. and Cooper, G. E. and Hart, R. N. and Dennis, B. C. and Freeman, S. W. and Cain, J. F. and others},
  title   = {{Initial Experience with Lecanemab and Lessons Learned in 71 Patients in a Regional Medical Center}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2024},
  doi     = {10.14283/jpad.2024.159},
  pmid    = {39559868},
  url     = {https://doi.org/10.14283/jpad.2024.159}
}

@article{dranitsaris2023-36964606,
  author  = {Dranitsaris, G. and Zhang, Q. and Mu, L. and Weyrer, C. and Drysdale, E. and Neumann, P. and Atri, A. and Monfared, A. A. T.},
  title   = {{Therapeutic preference for Alzheimer's disease treatments: a discrete choice experiment with caregivers and neurologists}},
  journal = {Alzheimer's research \& therapy},
  year    = {2023},
  doi     = {10.1186/s13195-023-01207-8},
  pmid    = {36964606},
  url     = {https://doi.org/10.1186/s13195-023-01207-8}
}

@article{klein2022-36474747,
  author  = {Klein, Gregory and Scelsi, Marzia A and Barakos, Jerome and Fiebach, Jochen B and Bracoud, Luc and Suhy, Joyce and Delmar, Paul and Lyons, Marco and others},
  title   = {{Comparing ARIA-E severity scales and effects of treatment management thresholds}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2022},
  doi     = {10.1002/dad2.12376},
  pmid    = {36474747},
  url     = {https://doi.org/10.1002/dad2.12376}
}

@article{arnold2018-30014506,
  author  = {Arnold, Steven E and Betensky, Rebecca A},
  title   = {{Multicrossover Randomized Controlled Trial Designs in Alzheimer Disease}},
  journal = {Annals of neurology},
  year    = {2018},
  doi     = {10.1002/ana.25280},
  pmid    = {30014506},
  url     = {https://doi.org/10.1002/ana.25280}
}

@article{schultz2017-28387023,
  author  = {Schultz, Brian R and Takeshita, Junji and Goebert, Deborah and Takeshita, Steven and Lu, Brett Y and Guilloux, Alexandre and Higa, Joy},
  title   = {{Simultaneous usage of dementia medications and anticholinergics among Asians and Pacific Islanders}},
  journal = {Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society},
  year    = {2017},
  doi     = {10.1111/psyg.12267},
  pmid    = {28387023},
  url     = {https://doi.org/10.1111/psyg.12267}
}

@article{bietry2017-28078633,
  author  = {Biétry, F. A. and Pfeil, A. M. and Reich, O. and Schwenkglenks, M. and Meier, C. R.},
  title   = {{Benzodiazepine Use and Risk of Developing Alzheimer's Disease: A Case-Control Study Based on Swiss Claims Data}},
  journal = {CNS drugs},
  year    = {2017},
  doi     = {10.1007/s40263-016-0404-x},
  pmid    = {28078633},
  url     = {https://doi.org/10.1007/s40263-016-0404-x}
}

@article{blaettler2016-916a25c5,
  author  = {Blaettler, Thomas and Smith, Janice and Smith, Jillian P. and Paul, Robert H. and Asnaghi, Veronica and Fuji, Reina N. and Quartino, Angelica Linnea and Honigberg, Lee A. and others},
  title   = {{P2‐003: Clinical Trial Design of Cread: A Randomized, Double‐Blind, Placebo‐Controlled, Parallel‐Group Phase 3 Study to Evaluate Crenezumab Treatment in Patients with Prodromal‐To‐Mild Alzheimer’s Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.06.1207},
  url     = {https://doi.org/10.1016/j.jalz.2016.06.1207}
}

@article{vasudev2015-26525997,
  author  = {Vasudev, A. and Shariff, S. Z. and Liu, K. and Burhan, A. M. and Herrmann, N. and Leonard, S. and Mamdani, M.},
  title   = {{Trends in Psychotropic Dispensing Among Older Adults with Dementia Living in Long-Term Care Facilities: 2004-2013}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2015},
  doi     = {10.1016/j.jagp.2015.07.001},
  pmid    = {26525997},
  url     = {https://doi.org/10.1016/j.jagp.2015.07.001}
}

@article{lombardo2015-d54d3985,
  author  = {Lombardo, Ilise and Ramaswamy, Geetha and Piscitelli, Stephen C. and Friedhoff, Lawrence T.},
  title   = {{DT‐01‐04: The efficacy of RVT‐101, a 5‐ht6 receptor antagonist, as an adjunct to donepezil in adults with mild‐to‐moderate Alzheimer's disease: Completer analysis of a phase 2b study}},
  journal = {Alzheimer s \& Dementia},
  year    = {2015},
  doi     = {10.1016/j.jalz.2015.08.154},
  url     = {https://doi.org/10.1016/j.jalz.2015.08.154}
}

@article{mori2015-88c17657,
  author  = {Mori, Etsuro and Ikeda, Manabu and Nagai, Reiko and Matsuo, Kazutaka and Nakagawa, Masaki and Kosaka, Kenji},
  title   = {{Long-term donepezil use for dementia with Lewy bodies: results from an open-label extension of Phase III trial}},
  journal = {Alzheimer's Research \& Therapy},
  year    = {2015},
  doi     = {10.1186/s13195-014-0081-2},
  url     = {https://doi.org/10.1186/s13195-014-0081-2}
}

@article{xu2015-6572f8e9,
  author  = {Xu, Jing and Wang, Li-Ling and Dammer, Eric B. and Li, Chun-Bo and Xu, Gang and Chen, Sheng-Di and Wang, Gang},
  title   = {{Melatonin for Sleep Disorders and Cognition in Dementia}},
  journal = {American Journal of Alzheimer's Disease \& Other Dementias®},
  year    = {2015},
  doi     = {10.1177/1533317514568005},
  url     = {https://doi.org/10.1177/1533317514568005}
}

@article{dubois2015-240dc82b,
  author  = {Dubois, Bruno and Chupin, Marie and Hampel, Harald and Lista, Simone and Cavedo, Enrica and Croisile, Bernard and Tisserand, Guy Louis and Touchon, Jacques and others},
  title   = {{Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease}},
  journal = {Alzheimer's \& Dementia},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.10.003},
  url     = {https://doi.org/10.1016/j.jalz.2014.10.003}
}

@article{voyer2015-f2ae00d2,
  author  = {Voyer, Philippe and McCusker, Jane and Cole, Martin G. and Monette, Johanne and Champoux, Nathalie and Ciampi, Antonio and Belzile, Eric and Richard, Hélène},
  title   = {{Behavioral and Psychological Symptoms of Dementia: How Long Does Every Behavior Last, and Are Particular Behaviors Associated With PRN Antipsychotic Agent Use?}},
  journal = {Journal of Gerontological Nursing},
  year    = {2015},
  doi     = {10.3928/00989134-20141030-01},
  url     = {https://doi.org/10.3928/00989134-20141030-01}
}

@article{hartley2015-25510383,
  author  = {Hartley, D. and Blumenthal, T. and Carrillo, M. and DiPaolo, G. and Esralew, L. and Gardiner, K. and Granholm, A. C. and Iqbal, K. and others},
  title   = {{Down syndrome and Alzheimer's disease: Common pathways, common goals}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.10.007},
  pmid    = {25510383},
  url     = {https://doi.org/10.1016/j.jalz.2014.10.007}
}

@article{gill2009-19433698,
  author  = {Gill, S. S. and Anderson, G. M. and Fischer, H. D. and Bell, C. M. and Li, P. and Normand, S. L. and Rochon, P. A.},
  title   = {{Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study}},
  journal = {Archives of internal medicine},
  year    = {2009},
  doi     = {10.1001/archinternmed.2009.43},
  pmid    = {19433698},
  url     = {https://doi.org/10.1001/archinternmed.2009.43}
}

@article{reitz2004-15148148,
  author  = {Reitz, C. and Tang, M. X. and Luchsinger, J. and Mayeux, R.},
  title   = {{Relation of plasma lipids to Alzheimer disease and vascular dementia}},
  journal = {Archives of neurology},
  year    = {2004},
  doi     = {10.1001/archneur.61.5.705},
  pmid    = {15148148},
  url     = {https://doi.org/10.1001/archneur.61.5.705}
}

@article{guo1999-10448805,
  author  = {Guo, Zhenchao and Fratiglioni, Laura and Zhu, Li and Fastbom, Johan and Winblad, Bengt G. and Viitanen, Matti H.},
  title   = {{Occurrence and Progression of Dementia in a Community Population Aged 75 Years and Older}},
  journal = {Archives of Neurology},
  year    = {1999},
  doi     = {10.1001/archneur.56.8.991},
  pmid    = {10448805},
  url     = {https://doi.org/10.1001/archneur.56.8.991}
}

@article{kanowski1996-8741021,
  author  = {Kanowski, Siegfried and Herrmann, W. and Stephan, K. and Wierich, Werner and Hörr, R},
  title   = {{Proof of Efficacy of the Ginkgo Biloba Special Extract EGb 761 in Outpatients Suffering from Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Multi-infarct Dementia}},
  journal = {Pharmacopsychiatry},
  year    = {1996},
  doi     = {10.1055/s-2007-979544},
  pmid    = {8741021},
  url     = {https://doi.org/10.1055/s-2007-979544}
}

@article{watkins1994-8139084,
  author  = {Watkins, Paul Brent},
  title   = {{Hepatotoxic Effects of Tacrine Administration in Patients With Alzheimer's Disease}},
  journal = {JAMA},
  year    = {1994},
  doi     = {10.1001/jama.1994.03510370044030},
  pmid    = {8139084},
  url     = {https://doi.org/10.1001/jama.1994.03510370044030}
}

@article{bastujigarin2011-20944650,
  author  = {Bastuji-Garin, S. and Joly, P. and Lemordant, P. and Sparsa, A. and Bedane, C. and Delaporte, E. and Roujeau, J. C. and Bernard, P. and others},
  title   = {{Risk factors for bullous pemphigoid in the elderly: a prospective case-control study}},
  journal = {The Journal of investigative dermatology},
  year    = {2011},
  doi     = {10.1038/jid.2010.301},
  pmid    = {20944650},
  url     = {https://doi.org/10.1038/jid.2010.301}
}

@article{wang2026-41123870,
  author  = {Wang, Yun-Han and Johnson, Kyle and Beradid, Sarah and Yin, Hui and Yu, Oriana H Y and Suissa, Samy and Azoulay, Laurent and Renoux, Christel},
  title   = {{Incretin-Based Drugs and the Risk of Dementia Among Patients with Type 2 Diabetes}},
  journal = {Drug safety},
  year    = {2026},
  doi     = {10.1007/s40264-025-01623-9},
  pmid    = {41123870},
  url     = {https://doi.org/10.1007/s40264-025-01623-9}
}

@article{rosenbloom2025-40355750,
  author  = {Rosenbloom, M. and Schnee, A. and Nimma, S. and Lutz, H. and Gzesh, D. and Weisman, D.},
  title   = {{Monoclonal antibody administration in an academic institution and private neurological practice: a tale of two clinics}},
  journal = {Journal of neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13142-9},
  pmid    = {40355750},
  url     = {https://doi.org/10.1007/s00415-025-13142-9}
}

@article{hu2025-40290431,
  author  = {Hu, H. and Zhao, Y. and Mao, J. and He, J. and Zhang, Y. and Ye, H. and Yang, X.},
  title   = {{A real-world pharmacovigilance study of adverse drug reactions associated with lecanemab and aducanumab based on WHO-VigiAccess and FAERS databases}},
  journal = {Frontiers in pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1561020},
  pmid    = {40290431},
  url     = {https://doi.org/10.3389/fphar.2025.1561020}
}

@article{kim2025-39944527,
  author  = {Kim, Yeshin and Kang, Dong Woo and Kim, Geon Ha and Kim, Ko Woon and Kim, Hee-Jin and Na, Seunghee and Park, Kee Hyung and Park, Young Ho and others},
  title   = {{Clinical Practice Guidelines for Dementia: Recommendations for Cholinesterase Inhibitors and Memantine}},
  journal = {Dementia and neurocognitive disorders},
  year    = {2025},
  doi     = {10.12779/dnd.2025.24.1.1},
  pmid    = {39944527},
  url     = {https://doi.org/10.12779/dnd.2025.24.1.1}
}

@article{frost2024-39766362,
  author  = {Frost, Emma D and Shi, Swanny X and Byroju, Vishnu V and Rissardo, Jamir Pitton and Donlon, Jack and Vigilante, Nicholas and Murray, Briana P and Walker, Ian M and others},
  title   = {{Galantamine-Memantine Combination in the Treatment of Parkinson's Disease Dementia}},
  journal = {Brain sciences},
  year    = {2024},
  doi     = {10.3390/brainsci14121163},
  pmid    = {39766362},
  url     = {https://doi.org/10.3390/brainsci14121163}
}

@article{cabrera2024-39221402,
  author  = {Cabrera, Carlos Luis Guanín and Jaramillo, Arturo P and Vallejo, Maria P and Cueva, Maria G and Grandes, Xavier and Grijalva, Mario Navarro and Guerrero, Over J Hidalgo},
  title   = {{Navigating Prevention: A Systematic Review of Strategies for Alzheimer's Disease in High-Risk and Affected Individuals}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.65972},
  pmid    = {39221402},
  url     = {https://doi.org/10.7759/cureus.65972}
}

@article{debattista2024-38993656,
  author  = {DeBattista, C. and Schatzberg, A. F.},
  title   = {{The Black Book of Psychotropic Dosing and Monitoring}},
  journal = {Psychopharmacology bulletin},
  year    = {2024},
  doi     = {10.64719/pb.4493},
  pmid    = {38993656},
  url     = {https://doi.org/10.64719/pb.4493}
}

@article{liu2022-36606270,
  author  = {Liu, Junguang and Chang, Dennis and Cordato, Dennis and Lee, Kien and Dixson, Hugh and Bensoussan, Alan and Chan, Daniel Kam Yin},
  title   = {{A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia}},
  journal = {Aging medicine (Milton (N.S.W))},
  year    = {2022},
  doi     = {10.1002/agm2.12230},
  pmid    = {36606270},
  url     = {https://doi.org/10.1002/agm2.12230}
}

@article{nabizadeh2022-35843348,
  author  = {Nabizadeh, Fardin and Kankam, Samuel Berchi and Balabandian, Mohammad and Hashemi, Seyedeh Melika and Sharifkazemi, Hossein and Rostami, Mohammad Reza},
  title   = {{Metformin use and brain atrophy in nondemented elderly individuals with diabetes}},
  journal = {Experimental gerontology},
  year    = {2022},
  doi     = {10.1016/j.exger.2022.111890},
  pmid    = {35843348},
  url     = {https://doi.org/10.1016/j.exger.2022.111890}
}

@article{thompson2022-35124654,
  author  = {Thompson, Richard E and Tuchman, Alan J and Alkon, Daniel L},
  title   = {{Bryostatin Placebo-Controlled Trials Indicate Cognitive Restoration Above Baseline for Advanced Alzheimer's Disease in the Absence of Memantine1}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-215545},
  pmid    = {35124654},
  url     = {https://doi.org/10.3233/jad-215545}
}

@article{cummings2021-34095440,
  author  = {Cummings, J. and Lee, G. and Zhong, K. and Fonseca, J. and Taghva, K.},
  title   = {{Alzheimer's disease drug development pipeline: 2021}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12179},
  pmid    = {34095440},
  url     = {https://doi.org/10.1002/trc2.12179}
}

@article{imbimbo2021-33575481,
  author  = {Imbimbo, Bruno P and Lucca, Ugo and Watling, Mark},
  title   = {{Can Anti-β-amyloid Monoclonal Antibodies Work in Autosomal Dominant Alzheimer Disease?}},
  journal = {Neurology. Genetics},
  year    = {2021},
  doi     = {10.1212/nxg.0000000000000535},
  pmid    = {33575481},
  url     = {https://doi.org/10.1212/nxg.0000000000000535}
}

@article{vivash2020-33199422,
  author  = {Vivash, Lucy and Malpas, Charles B and Churilov, Leonid and Walterfang, Mark and Brodtmann, Amy and Piguet, Olivier and Ahmed, Rebekah M and Bush, Ashley I and others},
  title   = {{A study protocol for a phase II randomised, double-blind, placebo-controlled trial of sodium selenate as a disease-modifying treatment for behavioural variant frontotemporal dementia}},
  journal = {BMJ open},
  year    = {2020},
  doi     = {10.1136/bmjopen-2020-040100},
  pmid    = {33199422},
  url     = {https://doi.org/10.1136/bmjopen-2020-040100}
}

@article{haeberlein2018-12a02583,
  author  = {Haeberlein, Samantha Budd and Gheuens, Sarah and Chen, Tianle and O'Gorman, John T. and von Rosenstiel, Philipp and Chiao, Ping and Wang, Guanfang and von Hehn, Christian and others},
  title   = {{Aducanumab 36-month data from PRIME: a randomized, double-blind, placebo-controlled Phase 1b study in patients with prodromal or mild Alzheimer’s disease (S2.004)}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.90.15_supplement.s2.004},
  url     = {https://doi.org/10.1212/wnl.90.15_supplement.s2.004}
}

@article{gomm2016-27567804,
  author  = {Gomm, W. and von Holt, K. and Thomé, F. and Broich, K. and Maier, W. and Weckbecker, K. and Fink, A. and Doblhammer, G. and others},
  title   = {{Regular Benzodiazepine and Z-Substance Use and Risk of Dementia: An Analysis of German Claims Data}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2016},
  doi     = {10.3233/jad-151006},
  pmid    = {27567804},
  url     = {https://doi.org/10.3233/jad-151006}
}

@article{kessing2010-20148870,
  author  = {Kessing, L. V. and Forman, J. L. and Andersen, P. K.},
  title   = {{Does lithium protect against dementia?}},
  journal = {Bipolar disorders},
  year    = {2010},
  doi     = {10.1111/j.1399-5618.2009.00788.x},
  pmid    = {20148870},
  url     = {https://doi.org/10.1111/j.1399-5618.2009.00788.x}
}

@article{nunes2007-17401045,
  author  = {Nunes, P. V. and Forlenza, O. V. and Gattaz, W. F.},
  title   = {{Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2007},
  doi     = {10.1192/bjp.bp.106.029868},
  pmid    = {17401045},
  url     = {https://doi.org/10.1192/bjp.bp.106.029868}
}

@article{cooke2006-16872233,
  author  = {Cooke, Jana R and Loredo, Jose S and Liu, Lianqi and Marler, Matthew and Corey-Bloom, Jody and Fiorentino, Lavinia and Harrison, Tamara and Ancoli-Israel, Sonia},
  title   = {{Acetylcholinesterase inhibitors and sleep architecture in patients with Alzheimer's disease}},
  journal = {Drugs \& aging},
  year    = {2006},
  doi     = {10.2165/00002512-200623060-00005},
  pmid    = {16872233},
  url     = {https://doi.org/10.2165/00002512-200623060-00005}
}

@article{tariot1998-9433339,
  author  = {Tariot, P. N. and Erb, R. and Podgorski, C. A. and Cox, C. and Patel, S. and Jakimovich, L. and Irvine, C.},
  title   = {{Efficacy and tolerability of carbamazepine for agitation and aggression in dementia}},
  journal = {The American journal of psychiatry},
  year    = {1998},
  doi     = {10.1176/ajp.155.1.54},
  pmid    = {9433339},
  url     = {https://doi.org/10.1176/ajp.155.1.54}
}

@article{rogers1993-8351023,
  author  = {Rogers, J. and Kirby, L. C. and Hempelman, SR. and Berry, D. L. and McGeer, P. L. and Kaszniak, A. W. and Zalinski, J. and Cofield, M. and others},
  title   = {{Clinical trial of indomethacin in Alzheimer's disease}},
  journal = {Neurology},
  year    = {1993},
  doi     = {10.1212/wnl.43.8.1609},
  pmid    = {8351023},
  url     = {https://doi.org/10.1212/wnl.43.8.1609}
}

@article{qudoos2026-41966037,
  author  = {Qudoos, Muhammad A and Elliott, David P},
  title   = {{Review of Donanemab and Lecanemab in Mild Dementia Stage of Alzheimer's Disease: Progress and Challenges}},
  journal = {The Senior care pharmacist},
  year    = {2026},
  doi     = {10.4140/tcp.n.2026.98},
  pmid    = {41966037},
  url     = {https://doi.org/10.4140/tcp.n.2026.98}
}

@article{khan2025-41388533,
  author  = {Khan, Ali R and Makhoul, Gennifer Wahbah and Raji, Mukaila A},
  title   = {{Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults}},
  journal = {Endocrine regulations},
  year    = {2025},
  doi     = {10.2478/enr-2025-0030},
  pmid    = {41388533},
  url     = {https://doi.org/10.2478/enr-2025-0030}
}

@article{sorod2025-41141199,
  author  = {Sorod, Patra and Chen, Grace I},
  title   = {{Hearing All About Donepezil: Its Role in the Field of Auditory Processing}},
  journal = {Cureus},
  year    = {2025},
  doi     = {10.7759/cureus.93143},
  pmid    = {41141199},
  url     = {https://doi.org/10.7759/cureus.93143}
}

@article{heneka2024-39549715,
  author  = {Heneka, Michael T and Morgan, David and Jessen, Frank},
  title   = {{Passive anti-amyloid β immunotherapy in Alzheimer's disease-opportunities and challenges}},
  journal = {Lancet (London, England)},
  year    = {2024},
  doi     = {10.1016/s0140-6736(24)01883-x},
  pmid    = {39549715},
  url     = {https://doi.org/10.1016/s0140-6736(24)01883-x}
}

@article{rentz2024-39306695,
  author  = {Rentz, D. M. and Aisen, P. S. and Atri, A. and Hitchcock, J. and Irizarry, M. and Landen, J. and Matthews, B. R. and Miller, D. S. and others},
  title   = {{Benefits and risks of FDA-approved amyloid-targeting antibodies for treatment of early Alzheimer's disease: Navigating clinician-patient engagement}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14199},
  pmid    = {39306695},
  url     = {https://doi.org/10.1002/alz.14199}
}

@article{geerts2024-38774587,
  author  = {Geerts, H. and Bergeler, S. and Walker, M. and Rose, R. H. and van der Graaf, P. H.},
  title   = {{Quantitative systems pharmacology-based exploration of relevant anti-amyloid therapy challenges in clinical practice}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2024},
  doi     = {10.1002/trc2.12474},
  pmid    = {38774587},
  url     = {https://doi.org/10.1002/trc2.12474}
}

@article{hoilundcarlsen2023-37414156,
  author  = {Høilund-Carlsen, Poul F and Revheim, Mona-Elisabeth and Costa, Tommaso and Alavi, Abass and Kepp, Kasper P and Sensi, Stefano L and Perry, George and Robakis, Nikolaos K and others},
  title   = {{Passive Alzheimer's immunotherapy: A promising or uncertain option?}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2023.101996},
  pmid    = {37414156},
  url     = {https://doi.org/10.1016/j.arr.2023.101996}
}

@article{mafi2022-35977233,
  author  = {Mafi, John N and Leng, Mei and Arbanas, Julia Cave and Tseng, Chi-Hong and Damberg, Cheryl L and Sarkisian, Catherine and Landon, Bruce E},
  title   = {{Estimated Annual Spending on Aducanumab in the US Medicare Program}},
  journal = {JAMA health forum},
  year    = {2022},
  doi     = {10.1001/jamahealthforum.2021.4495},
  pmid    = {35977233},
  url     = {https://doi.org/10.1001/jamahealthforum.2021.4495}
}

@article{klein2019-31831056,
  author  = {Klein, G. and Delmar, P. and Voyle, N. and Rehal, S. and Hofmann, C. and Abi-Saab, D. and Andjelkovic, M. and Ristic, S. and others},
  title   = {{Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis}},
  journal = {Alzheimer's research \& therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0559-z},
  pmid    = {31831056},
  url     = {https://doi.org/10.1186/s13195-019-0559-z}
}

@article{schultz2018-29507718,
  author  = {Schultz, B. G. and Patten, D. K. and Berlau, D. J.},
  title   = {{The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms}},
  journal = {Translational neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s40035-018-0110-3},
  pmid    = {29507718},
  url     = {https://doi.org/10.1186/s40035-018-0110-3}
}

@article{garay2017-27936965,
  author  = {Garay, Ricardo P and Grossberg, George T},
  title   = {{AVP-786 for the treatment of agitation in dementia of the Alzheimer's type}},
  journal = {Expert opinion on investigational drugs},
  year    = {2017},
  doi     = {10.1080/13543784.2017.1267726},
  pmid    = {27936965},
  url     = {https://doi.org/10.1080/13543784.2017.1267726}
}

@article{viglietta2016-5b6a5200,
  author  = {Viglietta, Vissia and O'Gorman, John T. and Williams, Leslie J. and Tian, Ying and Sandrock, Alfred W. and Doody, Rachelle Smith and Salloway, Stephen and Barkhof, Frederik and others},
  title   = {{Randomized, Double-Blind, Placebo-Controlled Studies to Evaluate Treatment with Aducanumab (BIIB037) in Patients with Early Alzheimer’s Disease: Phase 3 Study Design (S1.003)}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.86.16_supplement.s1.003},
  url     = {https://doi.org/10.1212/wnl.86.16_supplement.s1.003}
}

@article{ikeda2015-044b4853,
  author  = {Ikeda, Manabu and Mori, Etsuro and Matsuo, Kazutaka and Nakagawa, Masaki and Kosaka, Kenji},
  title   = {{Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial}},
  journal = {Alzheimer's Research \& Therapy},
  year    = {2015},
  doi     = {10.1186/s13195-014-0083-0},
  url     = {https://doi.org/10.1186/s13195-014-0083-0}
}

@article{hamilton2011-21670370,
  author  = {Hamilton, H. and Gallagher, P. and Ryan, C. and Byrne, S. and O'Mahony, D.},
  title   = {{Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients}},
  journal = {Archives of internal medicine},
  year    = {2011},
  doi     = {10.1001/archinternmed.2011.215},
  pmid    = {21670370},
  url     = {https://doi.org/10.1001/archinternmed.2011.215}
}

@article{sultzer2008-18519523,
  author  = {Sultzer, David L. and Thomas, Sonia and Tariot, Pierre N. and Dagerman, Karen and Lebowitz, Barry D. and Lyketsos, Constantine George and Rosenheck, Robert Alan and Hsiao, John and others},
  title   = {{Clinical Symptom Responses to Atypical Antipsychotic Medications in Alzheimer’s Disease: Phase 1 Outcomes From the CATIE-AD Effectiveness Trial}},
  journal = {American Journal of Psychiatry},
  year    = {2008},
  doi     = {10.1176/appi.ajp.2008.07111779},
  pmid    = {18519523},
  url     = {https://doi.org/10.1176/appi.ajp.2008.07111779}
}

@article{wagner2004-15277291,
  author  = {Wagner, A. K. and Zhang, F. and Soumerai, S. B. and Walker, A. M. and Gurwitz, J. H. and Glynn, R. J. and Ross-Degnan, D.},
  title   = {{Benzodiazepine use and hip fractures in the elderly: who is at greatest risk?}},
  journal = {Archives of internal medicine},
  year    = {2004},
  doi     = {10.1001/archinte.164.14.1567},
  pmid    = {15277291},
  url     = {https://doi.org/10.1001/archinte.164.14.1567}
}

@article{janson2004-14747300,
  author  = {Janson, J. and Laedtke, T. and Parisi, J. E. and O'Brien, P. and Petersen, R. C. and Butler, P. C.},
  title   = {{Increased risk of type 2 diabetes in Alzheimer disease}},
  journal = {Diabetes},
  year    = {2004},
  doi     = {10.2337/diabetes.53.2.474},
  pmid    = {14747300},
  url     = {https://doi.org/10.2337/diabetes.53.2.474}
}

@article{roe2002-12028169,
  author  = {Roe, C. M. and Anderson, M. J. and Spivack, B.},
  title   = {{Use of anticholinergic medications by older adults with dementia}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2002},
  doi     = {10.1046/j.1532-5415.2002.50208.x},
  pmid    = {12028169},
  url     = {https://doi.org/10.1046/j.1532-5415.2002.50208.x}
}

@article{jann2000-10641971,
  author  = {Jann, M W},
  title   = {{Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease}},
  journal = {Pharmacotherapy},
  year    = {2000},
  doi     = {10.1592/phco.20.1.1.34664},
  pmid    = {10641971},
  url     = {https://doi.org/10.1592/phco.20.1.1.34664}
}

@article{mouradian1988-3281057,
  author  = {Mouradian, M M and Mohr, E and Williams, J A and Chase, T N},
  title   = {{No response to high-dose muscarinic agonist therapy in Alzheimer's disease}},
  journal = {Neurology},
  year    = {1988},
  doi     = {10.1212/wnl.38.4.606},
  pmid    = {3281057},
  url     = {https://doi.org/10.1212/wnl.38.4.606}
}

@article{larson1987-2886086,
  author  = {Larson, E. B. and Kukull, W. A. and Buchner, D. and Reifler, B. V.},
  title   = {{Adverse drug reactions associated with global cognitive impairment in elderly persons}},
  journal = {Annals of internal medicine},
  year    = {1987},
  doi     = {10.7326/0003-4819-107-2-169},
  pmid    = {2886086},
  url     = {https://doi.org/10.7326/0003-4819-107-2-169}
}

@article{guizzaro2026-41852829,
  author  = {Guizzaro, L. and Bałkowiec-Iskra, E. and Haberkamp, M. and Mol, P. G. M. and Moreau, A. and Mueller-Berghaus, J. and Philadelphy, D. and Balabanov, P. and others},
  title   = {{Balancing benefit and risk in early Alzheimer's disease: the European Medicines Agency (EMA) assessment of lecanemab and donanemab}},
  journal = {The Lancet regional health. Europe},
  year    = {2026},
  doi     = {10.1016/j.lanepe.2026.101644},
  pmid    = {41852829},
  url     = {https://doi.org/10.1016/j.lanepe.2026.101644}
}

@article{filippi2026-41732200,
  author  = {Filippi, M. and Cecchetti, G. and Spinelli, E. G. and Ghirelli, A. and Rugarli, G. and Pisano, S. and Canu, E. and Agosta, F.},
  title   = {{Anti-amyloid therapies and the transformation of Alzheimer's care pathways: early lessons from the frontline}},
  journal = {The Lancet regional health. Europe},
  year    = {2026},
  doi     = {10.1016/j.lanepe.2026.101609},
  pmid    = {41732200},
  url     = {https://doi.org/10.1016/j.lanepe.2026.101609}
}

@article{higgins2026-41596530,
  author  = {Higgins, M. and Wasef, V. and Kwakowsky, A.},
  title   = {{FDA-Approved Passive Immunization Treatments Against Aβ in Alzheimer's Disease: Where Are We Now?}},
  journal = {International journal of molecular sciences},
  year    = {2026},
  doi     = {10.3390/ijms27020883},
  pmid    = {41596530},
  url     = {https://doi.org/10.3390/ijms27020883}
}

@article{joseph2023-37082807,
  author  = {Joseph, J. and Pajewski, N. M. and Dolor, R. J. and Sellers, M. A. and Perdue, L. H. and Peeples, SR. and Henrie, A. M. and Woolard, N. and others},
  title   = {{Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2023},
  doi     = {10.1111/jgs.18312},
  pmid    = {37082807},
  url     = {https://doi.org/10.1111/jgs.18312}
}

@article{siemers2023-36641606,
  author  = {Siemers, E. and Hitchcock, J. and Sundell, K. and Dean, R. and Jerecic, J. and Cline, E. and Iverson, K. and Moore, J. and others},
  title   = {{ACU193, a Monoclonal Antibody that Selectively Binds Soluble Aß Oligomers: Development Rationale, Phase 1 Trial Design, and Clinical Development Plan}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2023},
  doi     = {10.14283/jpad.2022.93},
  pmid    = {36641606},
  url     = {https://doi.org/10.14283/jpad.2022.93}
}

@article{howe2023-37874098,
  author  = {Howe, M. D. and Britton, K. J. and Joyce, H. E. and Pappas, G. J. and Faust, M. A. and Dawson, B. C. and Riddle, M. C. and Salloway, S. P.},
  title   = {{Initial Experiences with Amyloid-Related Imaging Abnormalities in Patients Receiving Aducanumab Following Accelerated Approval}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2023},
  doi     = {10.14283/jpad.2023.96},
  pmid    = {37874098},
  url     = {https://doi.org/10.14283/jpad.2023.96}
}

@article{charpignon2022-36496454,
  author  = {Charpignon, M. L. and Vakulenko-Lagun, B. and Zheng, B. and Magdamo, C. and Su, B. and Evans, K. and Rodriguez, S. and Sokolov, A. and others},
  title   = {{Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia}},
  journal = {Nature communications},
  year    = {2022},
  doi     = {10.1038/s41467-022-35157-w},
  pmid    = {36496454},
  url     = {https://doi.org/10.1038/s41467-022-35157-w}
}

@article{kim2022-35342092,
  author  = {Kim, C. K. and Lee, Y. R. and Ong, L. and Gold, M. and Kalali, A. and Sarkar, J.},
  title   = {{Alzheimer's Disease: Key Insights from Two Decades of Clinical Trial Failures}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-215699},
  pmid    = {35342092},
  url     = {https://doi.org/10.3233/jad-215699}
}

@article{buddhaeberlein2017-29181491,
  author  = {Budd Haeberlein, S. and O'Gorman, J. and Chiao, P. and Bussière, T. and von Rosenstiel, P. and Tian, Y. and Zhu, Y. and von Hehn, C. and others},
  title   = {{Clinical Development of Aducanumab, an Anti-Aβ Human Monoclonal Antibody Being Investigated for the Treatment of Early Alzheimer's Disease}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2017},
  doi     = {10.14283/jpad.2017.39},
  pmid    = {29181491},
  url     = {https://doi.org/10.14283/jpad.2017.39}
}

@article{claxton2015-25374101,
  author  = {Claxton, Amy and Baker, Laura D. and Hanson, Angela J. and Trittschuh, Emily H. and Cholerton, Brenna and Morgan, Amy and Callaghan, Maureen and Arbuckle, Matthew and others},
  title   = {{Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2015},
  doi     = {10.3233/jad-141791},
  pmid    = {25374101},
  url     = {https://doi.org/10.3233/jad-141791}
}

@article{relkin2014-25546751,
  author  = {Relkin, Norman R.},
  title   = {{Intravenous immunoglobulin for Alzheimer's disease}},
  journal = {Clinical \& Experimental Immunology},
  year    = {2014},
  doi     = {10.1111/cei.12500},
  pmid    = {25546751},
  url     = {https://doi.org/10.1111/cei.12500}
}

@article{chagas2014-25237116,
  author  = {Chagas, Marcos Hortes Nisihara and Zuardi, Antônio Waldo and Tumas, Vítor and Pena-Pereira, Márcio Alexandre and Sobreira, Emmanuelle Tavares Alves and Bergamaschi, Mateus M. and dos Santos, Antônio Carlos and Teixeira, Antônio Lúcio and others},
  title   = {{Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial}},
  journal = {Journal of Psychopharmacology},
  year    = {2014},
  doi     = {10.1177/0269881114550355},
  pmid    = {25237116},
  url     = {https://doi.org/10.1177/0269881114550355}
}

@article{venning2012-23121204,
  author  = {Venning, Vanessa A. and Taghipour, Kathy and Mustapa, M.F. Mohd and Highet, A.S. and Kirtschig, Gudula and Hughes, J.R. and McLelland, J. and McDonagh, Andrew J. G. and others},
  title   = {{British Association of Dermatologists’ guidelines for the management of bullous pemphigoid 2012}},
  journal = {British Journal of Dermatology},
  year    = {2012},
  doi     = {10.1111/bjd.12072},
  pmid    = {23121204},
  url     = {https://doi.org/10.1111/bjd.12072}
}

@article{wilcock2008-18294023,
  author  = {Wilcock, Gordon Keith and Ballard, Clive G. and Cooper, James A. and Loft, Henrik},
  title   = {{Memantine for Agitation/Aggression and Psychosis in Moderately Severe to Severe Alzheimer's Disease}},
  journal = {The Journal of Clinical Psychiatry},
  year    = {2008},
  doi     = {10.4088/jcp.v69n0302},
  pmid    = {18294023},
  url     = {https://doi.org/10.4088/jcp.v69n0302}
}

@article{ballard2002-12143909,
  author  = {Ballard, Clive G. and O'Brien, John Tiernan and Reichelt, Katharina and Perry, Elaine King},
  title   = {{Aromatherapy as a Safe and Effective Treatment for the Management of Agitation in Severe Dementia}},
  journal = {The Journal of Clinical Psychiatry},
  year    = {2002},
  doi     = {10.4088/jcp.v63n0703},
  pmid    = {12143909},
  url     = {https://doi.org/10.4088/jcp.v63n0703}
}

@article{kalia2025-41240919,
  author  = {Kalia, Lorraine V and Ikeda, Manabu and Sultana, Janet and Chouliaras, Leonidas and O'Brien, John T and Taylor, John-Paul},
  title   = {{The evolving therapeutic landscape of dementia with Lewy bodies}},
  journal = {The Lancet. Neurology},
  year    = {2025},
  doi     = {10.1016/s1474-4422(25)00323-0},
  pmid    = {41240919},
  url     = {https://doi.org/10.1016/s1474-4422(25)00323-0}
}

@article{jiang2025-40855523,
  author  = {Jiang, Xiangxiang and Lv, Gang and Franklin, Jordan and Li, Minghui and Lu, Z Kevin},
  title   = {{Causal effect of conventional anti-dementia drugs on economic burden: an orthogonal double/debiased machine learning approach}},
  journal = {BMC geriatrics},
  year    = {2025},
  doi     = {10.1186/s12877-025-06298-6},
  pmid    = {40855523},
  url     = {https://doi.org/10.1186/s12877-025-06298-6}
}

@article{cummings2025-40463637,
  author  = {Cummings, Jeffrey L and Zhou, Yadi and Lee, Garam and Zhong, Kate and Fonseca, Jorge and Leisgang-Osse, Amanda M and Cheng, Feixiong},
  title   = {{Alzheimer's disease drug development pipeline: 2025}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2025},
  doi     = {10.1002/trc2.70098},
  pmid    = {40463637},
  url     = {https://doi.org/10.1002/trc2.70098}
}

@article{cummings2025-39971900,
  author  = {Cummings, Jeffrey L and Zhou, Yadi and Van Stone, Alexandra and Cammann, Davis and Tonegawa-Kuji, Reina and Fonseca, Jorge and Cheng, Feixiong},
  title   = {{Drug repurposing for Alzheimer's disease and other neurodegenerative disorders}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-56690-4},
  pmid    = {39971900},
  url     = {https://doi.org/10.1038/s41467-025-56690-4}
}

@article{sun2024-37878862,
  author  = {Sun, Mingyang and Chen, Wan-Ming and Wu, Szu-Yuan and Zhang, Jiaqiang},
  title   = {{Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction}},
  journal = {Brain : a journal of neurology},
  year    = {2024},
  doi     = {10.1093/brain/awad366},
  pmid    = {37878862},
  url     = {https://doi.org/10.1093/brain/awad366}
}

@article{klein2024-38323738,
  author  = {Klein, Eric G and Schroeder, Krista and Wessels, Alette M and Phipps, Adam and Japha, Maureen and Schilling, Traci and Zimmer, Jennifer A},
  title   = {{How donanemab data address the coverage with evidence development questions}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13700},
  pmid    = {38323738},
  url     = {https://doi.org/10.1002/alz.13700}
}

@article{anderson2021-34499725,
  author  = {Anderson, Timothy S and Ayanian, John Z and Souza, Jeffrey and Landon, Bruce E},
  title   = {{Representativeness of Participants Eligible to Be Enrolled in Clinical Trials of Aducanumab for Alzheimer Disease Compared With Medicare Beneficiaries With Alzheimer Disease and Mild Cognitive Impairment}},
  journal = {JAMA},
  year    = {2021},
  doi     = {10.1001/jama.2021.15286},
  pmid    = {34499725},
  url     = {https://doi.org/10.1001/jama.2021.15286}
}

@article{koola2020-32829072,
  author  = {Koola, Maju Mathew},
  title   = {{Galantamine-Memantine combination in the treatment of Alzheimer's disease and beyond}},
  journal = {Psychiatry research},
  year    = {2020},
  doi     = {10.1016/j.psychres.2020.113409},
  pmid    = {32829072},
  url     = {https://doi.org/10.1016/j.psychres.2020.113409}
}

@article{malone2020-32874532,
  author  = {Malone, Katie and Hancox, Jules C},
  title   = {{QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine}},
  journal = {Therapeutic advances in drug safety},
  year    = {2020},
  doi     = {10.1177/2042098620942416},
  pmid    = {32874532},
  url     = {https://doi.org/10.1177/2042098620942416}
}

@article{hashweh2020-32037892,
  author  = {Hashweh, Nader Nael and Bartochowski, Zachary and Khoury, Rita and Grossberg, George T},
  title   = {{An evaluation of hydromethylthionine as a treatment option for Alzheimer's disease}},
  journal = {Expert opinion on pharmacotherapy},
  year    = {2020},
  doi     = {10.1080/14656566.2020.1719066},
  pmid    = {32037892},
  url     = {https://doi.org/10.1080/14656566.2020.1719066}
}

@article{ishii2018-29234900,
  author  = {Ishii, Nobuyoshi and Terao, Takeshi},
  title   = {{Trace lithium and mental health}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2018},
  doi     = {10.1007/s00702-017-1824-6},
  pmid    = {29234900},
  url     = {https://doi.org/10.1007/s00702-017-1824-6}
}

@article{raghav2006-20703343,
  author  = {Raghav, Sangeeta and Singh, Harjeet and Dalal, P K and Srivastava, J S and Asthana, O P},
  title   = {{Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment}},
  journal = {Indian journal of psychiatry},
  year    = {2006},
  doi     = {10.4103/0019-5545.31555},
  pmid    = {20703343},
  url     = {https://doi.org/10.4103/0019-5545.31555}
}

@article{schnieder2026-42714614,
  author  = {Schnieder, Marlena},
  title   = {{[Antibody therapy in Alzheimer's disease]}},
  journal = {Zeitschrift fur Gerontologie und Geriatrie},
  year    = {2026},
  doi     = {10.1007/s00391-026-02640-8},
  pmid    = {42714614},
  url     = {https://doi.org/10.1007/s00391-026-02640-8}
}

@article{mummery2026-41390238,
  author  = {Mummery, Catherine J and Rasmussen, Jill and Blackburn, Dan and Coulthard, Elizabeth and Davies, R Rhys and Dorsey, Rachel and Fox, Nick C and Hosseini, Akram A and others},
  title   = {{Lecanemab appropriate use recommendations for clinical practice in the UK}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2026},
  doi     = {10.1136/jnnp-2025-336597},
  pmid    = {41390238},
  url     = {https://doi.org/10.1136/jnnp-2025-336597}
}

@article{tziakouri2026-41567052,
  author  = {Tziakouri, Andria and Loser, Valentin and Vicino, Alex and Baumgartner, Thomas and Di Liberto, Giovanni and Pantazou, Vasiliki and Bernard-Valnet, Raphaël and Theaudin, Marie and others},
  title   = {{[Neurology : what's new in 2025]}},
  journal = {Revue medicale suisse},
  year    = {2026},
  doi     = {10.53738/revmed.2026.22.946.48114},
  pmid    = {41567052},
  url     = {https://doi.org/10.53738/revmed.2026.22.946.48114}
}

@article{goodall2026-41498480,
  author  = {Goodall, Louise S and Lennon, Matthew J and Sachdev, Perminder S and Gorelick, Philip B and Kovacic, Jason C and Samaras, Katherine},
  title   = {{Current and Emerging Therapeutic Approaches for Vascular Cognitive Impairment and Dementia}},
  journal = {Journal of the American College of Cardiology},
  year    = {2026},
  doi     = {10.1016/j.jacc.2025.09.1502},
  pmid    = {41498480},
  url     = {https://doi.org/10.1016/j.jacc.2025.09.1502}
}

@article{solfrizzi2026-41428477,
  author  = {Solfrizzi, Vincenzo and Imbimbo, Bruno P},
  title   = {{Comparing clinical effect sizes of SouvenaidTM, lecanemab, and donanemab in early Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2026},
  doi     = {10.1177/13872877251406221},
  pmid    = {41428477},
  url     = {https://doi.org/10.1177/13872877251406221}
}

@article{rabiei2025-41271757,
  author  = {Rabiei, K. and Petrella, JR. and Lenhart, S. and Liu, C. and Hao, W. and {Alzheimer Disease Neuroimaging Initiative}},
  title   = {{Data-driven modeling of amyloid-β targeted antibodies for Alzheimer's disease}},
  journal = {NPJ systems biology and applications},
  year    = {2025},
  doi     = {10.1038/s41540-025-00610-1},
  pmid    = {41271757},
  url     = {https://doi.org/10.1038/s41540-025-00610-1}
}

@article{papaliagkas2025-41096797,
  author  = {Papaliagkas, Vasileios T.},
  title   = {{Anti-Amyloid Therapies for Alzheimer’s Disease: Progress, Pitfalls, and the Path Ahead}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26199529},
  pmid    = {41096797},
  url     = {https://doi.org/10.3390/ijms26199529}
}

@article{alkhalifa2025-41003140,
  author  = {Alkhalifa, A. E. and Al Mokhlf, A. and Ali, H. and Al-Ghraiybah, N. F. and Syropoulou, V.},
  title   = {{Anti-Amyloid Monoclonal Antibodies for Alzheimer's Disease: Evidence, ARIA Risk, and Precision Patient Selection}},
  journal = {Journal of personalized medicine},
  year    = {2025},
  doi     = {10.3390/jpm15090437},
  pmid    = {41003140},
  url     = {https://doi.org/10.3390/jpm15090437}
}

@article{bobbins2025-40051090,
  author  = {Bobbins, A. and Davies, M. and Lynn, E. and Roy, D. and Yeomans, A. and Shakir, S. A. W.},
  title   = {{Safety and effectiveness of the anti-amyloid monoclonal antibody (mAb) drug lecanemab for early Alzheimer's disease: The pharmacovigilance perspective}},
  journal = {British journal of clinical pharmacology},
  year    = {2025},
  doi     = {10.1002/bcp.70021},
  pmid    = {40051090},
  url     = {https://doi.org/10.1002/bcp.70021}
}

@article{villain2025-40011173,
  author  = {Villain, N. and Planche, V. and Lilamand, M. and Cordonnier, C. and Soto-Martin, M. and Mollion, H. and Bombois, S. and Delrieu, J. and others},
  title   = {{Lecanemab for early Alzheimer's disease: Appropriate use recommendations from the French federation of memory clinics}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100094},
  pmid    = {40011173},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100094}
}

@article{kim2025-39865265,
  author  = {Kim, B. H. and Kim, S. and Nam, Y. and Park, Y. H. and Shin, S. M. and Moon, M.},
  title   = {{Second-generation anti-amyloid monoclonal antibodies for Alzheimer's disease: current landscape and future perspectives}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00465-w},
  pmid    = {39865265},
  url     = {https://doi.org/10.1186/s40035-025-00465-w}
}

@article{park2024-39512702,
  author  = {Park, K. H. and Kim, G. H. and Kim, C. H. and Koh, S. H. and Moon, S. Y. and Park, Y. H. and Seo, S. W. and Yoon, B. and others},
  title   = {{Lecanemab: Appropriate Use Recommendations by Korean Dementia Association}},
  journal = {Dementia and neurocognitive disorders},
  year    = {2024},
  doi     = {10.12779/dnd.2024.23.4.165},
  pmid    = {39512702},
  url     = {https://doi.org/10.12779/dnd.2024.23.4.165}
}

@article{vukmir2024-38939962,
  author  = {Vukmir, R. B.},
  title   = {{Amyloid-related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid-modifying therapy}},
  journal = {Annals of clinical and translational neurology},
  year    = {2024},
  doi     = {10.1002/acn3.52042},
  pmid    = {38939962},
  url     = {https://doi.org/10.1002/acn3.52042}
}

@article{yoon2024-38779110,
  author  = {Yoon, C. H. and Groff, C. and Criss, O.},
  title   = {{Lecanemab: A Second in Class Therapy for the Management of Early Alzheimer's Disease}},
  journal = {Innovations in pharmacy},
  year    = {2024},
  doi     = {10.24926/iip.v15i1.5787},
  pmid    = {38779110},
  url     = {https://doi.org/10.24926/iip.v15i1.5787}
}

@article{bilodeau2024-38592119,
  author  = {Bilodeau, P. A. and Dickson, JR. and Kozberg, M. G.},
  title   = {{The Impact of Anti-Amyloid Immunotherapies on Stroke Care}},
  journal = {Journal of clinical medicine},
  year    = {2024},
  doi     = {10.3390/jcm13051245},
  pmid    = {38592119},
  url     = {https://doi.org/10.3390/jcm13051245}
}

@article{doran2024-38312931,
  author  = {Doran, S. J. and Sawyer, R. P.},
  title   = {{Risk factors in developing amyloid related imaging abnormalities (ARIA) and clinical implications}},
  journal = {Frontiers in neuroscience},
  year    = {2024},
  doi     = {10.3389/fnins.2024.1326784},
  pmid    = {38312931},
  url     = {https://doi.org/10.3389/fnins.2024.1326784}
}

@article{freund2023-37942822,
  author  = {Freund, Wolfgang and Weber, Frank},
  title   = {{The Function of Sleep and the Treatment of Primary Insomnia}},
  journal = {Deutsches Arzteblatt international},
  year    = {2023},
  doi     = {10.3238/arztebl.m2023.0228},
  pmid    = {37942822},
  url     = {https://doi.org/10.3238/arztebl.m2023.0228}
}

@article{rhea2024-38095516,
  author  = {Rhea, E. M. and Babin, A. and Thomas, P. and Omer, M. and Weaver, R. and Hansen, K. and Banks, W. A. and Talbot, K.},
  title   = {{Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases}},
  journal = {Tissue barriers},
  year    = {2024},
  doi     = {10.1080/21688370.2023.2292461},
  pmid    = {38095516},
  url     = {https://doi.org/10.1080/21688370.2023.2292461}
}

@article{colucci2023-38027469,
  author  = {Colucci, Fabiana and Avenali, Micol and De Micco, Rosita and Poli, Marco Fusar and Cerri, Silvia and Stanziano, Mario and Bacila, Ana and Cuconato, Giada and others},
  title   = {{Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment in GBA-associated Parkinson's disease: a multicentre, randomised, double-blind, placebo-controlled, phase II trial. The AMBITIOUS study protocol}},
  journal = {BMJ neurology open},
  year    = {2023},
  doi     = {10.1136/bmjno-2023-000535},
  pmid    = {38027469},
  url     = {https://doi.org/10.1136/bmjno-2023-000535}
}

@article{cummings2024-37955845,
  author  = {Cummings, J. and Osse, A. M. L. and Cammann, D. and Powell, J. and Chen, J.},
  title   = {{Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer's Disease}},
  journal = {BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy},
  year    = {2024},
  doi     = {10.1007/s40259-023-00633-2},
  pmid    = {37955845},
  url     = {https://doi.org/10.1007/s40259-023-00633-2}
}

@article{sadlon2023-37881360,
  author  = {Sadlon, Angélique and Ott, Martin and Kressig, Reto W},
  title   = {{Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature}},
  journal = {Frontiers in aging neuroscience},
  year    = {2023},
  doi     = {10.3389/fnagi.2023.1256968},
  pmid    = {37881360},
  url     = {https://doi.org/10.3389/fnagi.2023.1256968}
}

@article{kurkinen2023-37831471,
  author  = {Kurkinen, Markku},
  title   = {{Donanemab: Not two without a third}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2023},
  doi     = {10.17219/acem/172673},
  pmid    = {37831471},
  url     = {https://doi.org/10.17219/acem/172673}
}

@article{olazaran2023-37537656,
  author  = {Olazarán, Javier and Carnero-Pardo, Cristóbal and Fortea, Juan and Sánchez-Juan, Pascual and García-Ribas, Guillermo and Viñuela, Félix and Martínez-Lage, Pablo and Boada, Mercè},
  title   = {{Prevalence of treated patients with Alzheimer's disease: current trends and COVID-19 impact}},
  journal = {Alzheimer's research \& therapy},
  year    = {2023},
  doi     = {10.1186/s13195-023-01271-0},
  pmid    = {37537656},
  url     = {https://doi.org/10.1186/s13195-023-01271-0}
}

@article{gueorguieva2023-37388759,
  author  = {Gueorguieva, Ivelina and Willis, Brian A and Chua, Laiyi and Chow, Kay and Ernest, C Steven and Wang, Jian and Shcherbinin, Sergey and Sims, John R and others},
  title   = {{Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2023},
  doi     = {10.1002/trc2.12404},
  pmid    = {37388759},
  url     = {https://doi.org/10.1002/trc2.12404}
}

@article{hardy2023-36797987,
  author  = {Hardy, John and Mummery, Catherine},
  title   = {{An anti-amyloid therapy works for Alzheimer's disease: why has it taken so long and what is next?}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awad049},
  pmid    = {36797987},
  url     = {https://doi.org/10.1093/brain/awad049}
}

@article{gueorguieva2023-36805552,
  author  = {Gueorguieva, I. and Willis, B. A. and Chua, L. and Chow, K. and Ernest, C. S. and Shcherbinin, S. and Ardayfio, P. and Mullins, G. R. and others},
  title   = {{Donanemab Population Pharmacokinetics, Amyloid Plaque Reduction, and Safety in Participants with Alzheimer's Disease}},
  journal = {Clinical pharmacology and therapeutics},
  year    = {2023},
  doi     = {10.1002/cpt.2875},
  pmid    = {36805552},
  url     = {https://doi.org/10.1002/cpt.2875}
}

@article{hao2022-36054214,
  author  = {Hao, Wenrui and Lenhart, Suzanne and Petrella, Jeffrey R},
  title   = {{Optimal anti-amyloid-beta therapy for Alzheimer's disease via a personalized mathematical model}},
  journal = {PLoS computational biology},
  year    = {2022},
  doi     = {10.1371/journal.pcbi.1010481},
  pmid    = {36054214},
  url     = {https://doi.org/10.1371/journal.pcbi.1010481}
}

@article{marrodan2022-35136969,
  author  = {Marrodan, Mariano and Fiol, Marcela P and Correale, Jorge},
  title   = {{Susac syndrome: challenges in the diagnosis and treatment}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awab476},
  pmid    = {35136969},
  url     = {https://doi.org/10.1093/brain/awab476}
}

@article{madrasi2021-33938131,
  author  = {Madrasi, Kumpal and Das, Raibatak and Mohmmadabdul, Hafiz and Lin, Lin and Hyman, Bradley T and Lauffenburger, Douglas A and Albers, Mark W and Rissman, Robert A and others},
  title   = {{Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12312},
  pmid    = {33938131},
  url     = {https://doi.org/10.1002/alz.12312}
}

@article{bloem2021-33848468,
  author  = {Bloem, B. R. and Okun, M. S. and Klein, C.},
  title   = {{Parkinson's disease}},
  journal = {Lancet (London, England)},
  year    = {2021},
  doi     = {10.1016/s0140-6736(21)00218-x},
  pmid    = {33848468},
  url     = {https://doi.org/10.1016/s0140-6736(21)00218-x}
}

@article{friedman2021-33674360,
  author  = {Friedman, Lauren G and McKeehan, Nicholas and Hara, Yuko and Cummings, Jeffrey L and Matthews, Dawn C and Zhu, Jian and Mohs, Richard C and Wang, Deli and others},
  title   = {{Value-Generating Exploratory Trials in Neurodegenerative Dementias}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000011774},
  pmid    = {33674360},
  url     = {https://doi.org/10.1212/wnl.0000000000011774}
}

@article{wu2021-33718584,
  author  = {Wu, Chong and Wu, Lang and Wang, Jingshen and Lin, Lifeng and Li, Yanming and Lu, Qing and Deng, Hong-Wen},
  title   = {{Systematic identification of risk factors and drug repurposing options for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12148},
  pmid    = {33718584},
  url     = {https://doi.org/10.1002/trc2.12148}
}

@article{cummings2019-31334330,
  author  = {Cummings, J. and Lee, G. and Ritter, A. and Sabbagh, M. and Zhong, K.},
  title   = {{Alzheimer's disease drug development pipeline: 2019}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2019},
  doi     = {10.1016/j.trci.2019.05.008},
  pmid    = {31334330},
  url     = {https://doi.org/10.1016/j.trci.2019.05.008}
}

@article{lefaucheur2017-27866120,
  author  = {Lefaucheur, J. P. and Antal, A. and Ayache, S. S. and Benninger, D. H. and Brunelin, J. and Cogiamanian, F. and Cotelli, M. and De Ridder, D. and others},
  title   = {{Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)}},
  journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
  year    = {2017},
  doi     = {10.1016/j.clinph.2016.10.087},
  pmid    = {27866120},
  url     = {https://doi.org/10.1016/j.clinph.2016.10.087}
}

@article{naharci2015-25777522,
  author  = {Naharci, Mehmet Ilkin and Ozturk, Ahmet and Yasar, Halit and Cintosun, Umit and Kocak, Necmettin and Bozoglu, Ergun and Tasci, Ilker and Doruk, Huseyin},
  title   = {{Galantamine improves sleep quality in patients with dementia}},
  journal = {Acta neurologica Belgica},
  year    = {2015},
  doi     = {10.1007/s13760-015-0453-9},
  pmid    = {25777522},
  url     = {https://doi.org/10.1007/s13760-015-0453-9}
}

@article{matsuzono2015-25624417,
  author  = {Matsuzono, Kosuke and Hishikawa, Nozomi and Ohta, Yasuyuki and Yamashita, Toru and Deguchi, Kentaro and Nakano, Yumiko and Abe, Koji},
  title   = {{Combination Therapy of Cholinesterase Inhibitor (Donepezil or Galantamine) plus Memantine in the Okayama Memantine Study}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2015},
  doi     = {10.3233/jad-143084},
  pmid    = {25624417},
  url     = {https://doi.org/10.3233/jad-143084}
}

@article{evans2009-19558254,
  author  = {Evans, Marcella A. and Golomb, Beatrice Alexandra},
  title   = {{Statin‐Associated Adverse Cognitive Effects: Survey Results from 171 Patients}},
  journal = {Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy},
  year    = {2009},
  doi     = {10.1592/phco.29.7.800},
  pmid    = {19558254},
  url     = {https://doi.org/10.1592/phco.29.7.800}
}

@article{leroi2004-14716693,
  author  = {Leroi, Iracema and Brandt, Jason and Reich, Stephen G. and Lyketsos, Constantine George and Grill, Stephen E. and Thompson, Richard E. and Marsh, Laura},
  title   = {{Randomized placebo‐controlled trial of donepezil in cognitive impairment in Parkinson's disease}},
  journal = {International Journal of Geriatric Psychiatry},
  year    = {2004},
  doi     = {10.1002/gps.993},
  pmid    = {14716693},
  url     = {https://doi.org/10.1002/gps.993}
}

@article{lebert2004-15178953,
  author  = {Lebert, Florence and Stekke, Willy and Hasenbroekx, Christine and Pasquier, Florence},
  title   = {{Frontotemporal Dementia: A Randomised, Controlled Trial with Trazodone}},
  journal = {Dementia and Geriatric Cognitive Disorders},
  year    = {2004},
  doi     = {10.1159/000077171},
  pmid    = {15178953},
  url     = {https://doi.org/10.1159/000077171}
}

@article{scott2000-11129124,
  author  = {Scott, L. J. and Goa, K. L.},
  title   = {{Galantamine: a review of its use in Alzheimer's disease}},
  journal = {Drugs},
  year    = {2000},
  doi     = {10.2165/00003495-200060050-00008},
  pmid    = {11129124},
  url     = {https://doi.org/10.2165/00003495-200060050-00008}
}

@article{edwards2007-17409748,
  author  = {Edwards, K. and Royall, D. and Hershey, L. and Lichter, D. and Hake, A. and Farlow, M. and Pasquier, F. and Johnson, S.},
  title   = {{Efficacy and safety of galantamine in patients with dementia with Lewy bodies: a 24-week open-label study}},
  journal = {Dementia and geriatric cognitive disorders},
  year    = {2007},
  doi     = {10.1159/000101512},
  pmid    = {17409748},
  url     = {https://doi.org/10.1159/000101512}
}

@article{llibreguerra2025-41184455,
  author  = {Llibre-Guerra, Jorge J and McDade, Eric M and Schindler, Suzanne E and Clifford, David B and Supnet, Charlene and Atri, Alireza and Bateman, Randall J},
  title   = {{Towards pharmacological prevention of Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2025},
  doi     = {10.1038/s41582-025-01154-y},
  pmid    = {41184455},
  url     = {https://doi.org/10.1038/s41582-025-01154-y}
}

@article{noto2025-41035821,
  author  = {Noto, Natalia Motzko and Speth, Robert C and Robison, Lisa S},
  title   = {{Cerebral amyloid angiopathy: a narrative review}},
  journal = {Frontiers in aging neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1632252},
  pmid    = {41035821},
  url     = {https://doi.org/10.3389/fnagi.2025.1632252}
}

@article{holscher2025-40938528,
  author  = {Hölscher, Christian},
  title   = {{Incretin Hormones GLP-1 and GIP Normalize Energy Utilization and Reduce Inflammation in the Brain in Alzheimer's Disease and Parkinson's Disease: From Repurposed GLP-1 Receptor Agonists to Novel Dual GLP-1/GIP Receptor Agonists as Potential Disease-Modifying Therapies}},
  journal = {CNS drugs},
  year    = {2025},
  doi     = {10.1007/s40263-025-01226-z},
  pmid    = {40938528},
  url     = {https://doi.org/10.1007/s40263-025-01226-z}
}

@article{arai2025-40708311,
  author  = {Arai, Heii and Aiba, Satoko and Arai, Reiko},
  title   = {{Safety of switching from lecanemab to donanemab in 20 consecutive patients with Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877251361051},
  pmid    = {40708311},
  url     = {https://doi.org/10.1177/13872877251361051}
}

@article{ota2025-41047647,
  author  = {Ota, Miho and Arai, Tetsuaki},
  title   = {{[Pharmacological Interventions in Dementia]}},
  journal = {No shinkei geka. Neurological surgery},
  year    = {2025},
  doi     = {10.11477/mf.030126030530050943},
  pmid    = {41047647},
  url     = {https://doi.org/10.11477/mf.030126030530050943}
}

@article{sabbagh2025-40782673,
  author  = {Sabbagh, Marwan Noel and Kennedy, Jessica and Majeed, Jad and Decourt, Boris},
  title   = {{Alzheimer's disease: Clinical trials to watch}},
  journal = {Med (New York, N.Y.)},
  year    = {2025},
  doi     = {10.1016/j.medj.2025.100771},
  pmid    = {40782673},
  url     = {https://doi.org/10.1016/j.medj.2025.100771}
}

@article{hardy2025-40739944,
  author  = {Hardy, John},
  title   = {{Alzheimer's Disease: Treatment Challenges for the Future}},
  journal = {Journal of neurochemistry},
  year    = {2025},
  doi     = {10.1111/jnc.70176},
  pmid    = {40739944},
  url     = {https://doi.org/10.1111/jnc.70176}
}

@article{loi2025-40550741,
  author  = {Loi, Samantha M and Kang, Matthew Jy},
  title   = {{Donanemab: The dawn of disease-modifying treatment for Alzheimer's disease in Australia}},
  journal = {Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists},
  year    = {2025},
  doi     = {10.1177/10398562251355157},
  pmid    = {40550741},
  url     = {https://doi.org/10.1177/10398562251355157}
}

@article{giannakis2025-40393205,
  author  = {Giannakis, Alexandros and Konitsiotis, Spiridon},
  title   = {{Anti-Amyloid Agents: A Self-Fulfilling prophecy}},
  journal = {Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year    = {2025},
  doi     = {10.1016/j.jocn.2025.111338},
  pmid    = {40393205},
  url     = {https://doi.org/10.1016/j.jocn.2025.111338}
}

@article{office2025-40429612,
  author  = {Office, Internation Journal Of Molecular Sciences Editorial},
  title   = {{Expression of Concern: Paladugu et al. Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer's Disease. Int. J. Mol. Sci. 2021, 22, 860}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26104467},
  pmid    = {40429612},
  url     = {https://doi.org/10.3390/ijms26104467}
}

@article{cummings2025-40118715,
  author  = {Cummings, Jeffrey L},
  title   = {{Maximizing the benefit and managing the risk of anti-amyloid monoclonal antibody therapy for Alzheimer's disease: Strategies and research directions}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2025},
  doi     = {10.1016/j.neurot.2025.e00570},
  pmid    = {40118715},
  url     = {https://doi.org/10.1016/j.neurot.2025.e00570}
}

@article{tampi2025-40078953,
  author  = {Tampi, Rajesh R},
  title   = {{Lecanemab for mild Alzheimer disease - is there a way forward?}},
  journal = {Drugs in context},
  year    = {2025},
  doi     = {10.7573/dic.2024-12-2},
  pmid    = {40078953},
  url     = {https://doi.org/10.7573/dic.2024-12-2}
}

@article{sawamura2025-40001315,
  author  = {Sawamura, Toshitaka and Karashima, Shigehiro and Ohmori, Ai and Kometani, Mitsuhiro and Yoneda, Takashi},
  title   = {{Impacts of tirzepatide on older patients with diminished β-cell function and dementia}},
  journal = {Geriatrics \& gerontology international},
  year    = {2025},
  doi     = {10.1111/ggi.70018},
  pmid    = {40001315},
  url     = {https://doi.org/10.1111/ggi.70018}
}

@article{olluri2025-39908690,
  author  = {Olluri, Andi},
  title   = {{Clinical trials targeting tau should be halted}},
  journal = {Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year    = {2025},
  doi     = {10.1016/j.jocn.2025.111101},
  pmid    = {39908690},
  url     = {https://doi.org/10.1016/j.jocn.2025.111101}
}

@article{pillarisetti2025-39902055,
  author  = {Pillarisetti, Lekha and Agrawal, Devendra K},
  title   = {{Semaglutide: Double-edged Sword with Risks and Benefits}},
  journal = {Archives of internal medicine research},
  year    = {2025},
  doi     = {10.26502/aimr.0189},
  pmid    = {39902055},
  url     = {https://doi.org/10.26502/aimr.0189}
}

@article{barkerhaliski2025-39784685,
  author  = {Barker-Haliski, Melissa},
  title   = {{Seizing the opportunity to therapeutically address neuronal hyperexcitability in Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877241305740},
  pmid    = {39784685},
  url     = {https://doi.org/10.1177/13872877241305740}
}

@article{imbimbo2025-39623197,
  author  = {Imbimbo, Camillo and Ramusino, Matteo Cotta and Leone, Silvia and Mazzacane, Federico and De Franco, Valentino and Gatti, Alberto and Perini, Giulia and Costa, Alfredo},
  title   = {{Emerging Pharmacological Approaches for Psychosis and Agitation in Alzheimer's Disease}},
  journal = {CNS drugs},
  year    = {2025},
  doi     = {10.1007/s40263-024-01133-9},
  pmid    = {39623197},
  url     = {https://doi.org/10.1007/s40263-024-01133-9}
}

@article{geldmacher2024-39620846,
  author  = {Geldmacher, David S},
  title   = {{Treatment of Alzheimer Disease}},
  journal = {Continuum (Minneapolis, Minn.)},
  year    = {2024},
  doi     = {10.1212/con.0000000000001503},
  pmid    = {39620846},
  url     = {https://doi.org/10.1212/con.0000000000001503}
}

@article{zhu2024-39654705,
  author  = {Zhu, Wenwen and Huang, Lishan and Cheng, Hanxing and Li, Nanxi and Zhang, Bin and Dai, Wenbin and Wu, Xiao and Zhang, Dechou and others},
  title   = {{GABA and its receptors' mechanisms in the treatment of insomnia}},
  journal = {Heliyon},
  year    = {2024},
  doi     = {10.1016/j.heliyon.2024.e40665},
  pmid    = {39654705},
  url     = {https://doi.org/10.1016/j.heliyon.2024.e40665}
}

@article{masters2025-39668075,
  author  = {Masters, Colin L},
  title   = {{Neuropathology meets chemical and genetic pathology head-on: a personal perspective}},
  journal = {Pathology},
  year    = {2025},
  doi     = {10.1016/j.pathol.2024.11.001},
  pmid    = {39668075},
  url     = {https://doi.org/10.1016/j.pathol.2024.11.001}
}

@article{hales2025-39893023,
  author  = {Hales, Chadwick M},
  title   = {{Alzheimer's Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies}},
  journal = {The Medical clinics of North America},
  year    = {2025},
  doi     = {10.1016/j.mcna.2024.10.003},
  pmid    = {39893023},
  url     = {https://doi.org/10.1016/j.mcna.2024.10.003}
}

@article{rybakowski2024-39510063,
  author  = {Rybakowski, Janusz K},
  title   = {{Lithium: Fifteen Years Later}},
  journal = {Neuropsychobiology},
  year    = {2024},
  doi     = {10.1159/000542490},
  pmid    = {39510063},
  url     = {https://doi.org/10.1159/000542490}
}

@article{shir2024-39704652,
  author  = {Shir, Dror and Shiner, Tamara and Bregman, Noa},
  title   = {{Anti-amyloid treatments for Alzheimer's disease: A study on physicians' perspectives}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.1177/13872877241289788},
  pmid    = {39704652},
  url     = {https://doi.org/10.1177/13872877241289788}
}

@article{hunter2024-39443750,
  author  = {Hunter, Philip},
  title   = {{The controversy around anti-amyloid antibodies for treating Alzheimer's disease : The European Medical Agency's ruling against the latest anti-amyloid drugs highlights the ongoing debate about their safety and efficacy}},
  journal = {EMBO reports},
  year    = {2024},
  doi     = {10.1038/s44319-024-00294-4},
  pmid    = {39443750},
  url     = {https://doi.org/10.1038/s44319-024-00294-4}
}

@article{kumar2024-38270120,
  author  = {Kumar, Ashish and Kim, Fred and Song, Dong-Keun and Choung, Jai Jun},
  title   = {{Polypharmacological Potential of Phosphodiesterase 5 Inhibitors for the Treatment of Neurocognitive Disorders}},
  journal = {Aging and disease},
  year    = {2024},
  doi     = {10.14336/ad.2023.1129},
  pmid    = {38270120},
  url     = {https://doi.org/10.14336/ad.2023.1129}
}

@article{mok2024-39283037,
  author  = {Mok, Vincent Chung Tong and Cai, Yuan and Markus, Hugh S},
  title   = {{Vascular cognitive impairment and dementia: Mechanisms, treatment, and future directions}},
  journal = {International journal of stroke : official journal of the International Stroke Society},
  year    = {2024},
  doi     = {10.1177/17474930241279888},
  pmid    = {39283037},
  url     = {https://doi.org/10.1177/17474930241279888}
}

@article{jaqua2024-39283851,
  author  = {Jaqua, Ecler Ercole and Tran, Mai-Linh N and Hanna, Mary},
  title   = {{Alzheimer Disease: Treatment of Cognitive and Functional Symptoms}},
  journal = {American family physician},
  year    = {2024},
  pmid    = {39283851}
}

@article{mitchell2024-38951633,
  author  = {Mitchell, Alexandra K and Ehrenkranz, Rebecca and Franzen, Sanne and Han, Sae H and Shakur, Mujaahida and McGowan, Melissa and Massett, Holly A},
  title   = {{Analysis of eligibility criteria in Alzheimer's and related dementias clinical trials}},
  journal = {Scientific reports},
  year    = {2024},
  doi     = {10.1038/s41598-024-65767-x},
  pmid    = {38951633},
  url     = {https://doi.org/10.1038/s41598-024-65767-x}
}

@article{abdulrazeq2024-39959894,
  author  = {Abdulrazeq, Hael and Taman, Mazen and Ali, Rohaid and Doberstein, Cody and Sullivan, Patricia and Sampath, Prakash and Telfeian, Albert and Gokaslan, Ziya and others},
  title   = {{GLP-1 Receptor Agonists: Beyond Diabetes-What the Neurosurgeon Needs to Know}},
  journal = {Neurosurgery practice},
  year    = {2024},
  doi     = {10.1227/neuprac.0000000000000098},
  pmid    = {39959894},
  url     = {https://doi.org/10.1227/neuprac.0000000000000098}
}

@article{sarkar2024-38919471,
  author  = {Sarkar, Aparajita and Fanous, Kareem Imad and Marei, Isra and Ding, Hong and Ladjimi, Moncef and MacDonald, Ross and Hollenberg, Morley D and Anderson, Todd J and others},
  title   = {{Repurposing Metformin for the Treatment of Atrial Fibrillation: Current Insights}},
  journal = {Vascular health and risk management},
  year    = {2024},
  doi     = {10.2147/vhrm.s391808},
  pmid    = {38919471},
  url     = {https://doi.org/10.2147/vhrm.s391808}
}

@article{alhorani2024-40828109,
  author  = {Al-Horani, Rami A},
  title   = {{Sulfopropanoic acid derivatives for treating neurodegenerative disorders: a patent spotlight}},
  journal = {Pharmaceutical patent analyst},
  year    = {2024},
  doi     = {10.1080/20468954.2024.2363657},
  pmid    = {40828109},
  url     = {https://doi.org/10.1080/20468954.2024.2363657}
}

@article{hoilundcarlsen2024-38830549,
  author  = {Høilund-Carlsen, Poul F and Alavi, Abass and Barrio, Jorge R and Castellani, Rudolph J and Costa, Tommaso and Herrup, Karl and Kepp, Kasper P and Neve, Rachael L and others},
  title   = {{Donanemab, another anti-Alzheimer's drug with risk and uncertain benefit}},
  journal = {Ageing research reviews},
  year    = {2024},
  doi     = {10.1016/j.arr.2024.102348},
  pmid    = {38830549},
  url     = {https://doi.org/10.1016/j.arr.2024.102348}
}

@article{torres2024-39079148,
  author  = {Torres, Astrid and Camargo, Loida and López, Norman},
  title   = {{Aducanumab: A look two years after its approval}},
  journal = {Biomedica : revista del Instituto Nacional de Salud},
  year    = {2024},
  doi     = {10.7705/biomedica.6967},
  pmid    = {39079148},
  url     = {https://doi.org/10.7705/biomedica.6967}
}

@article{shukla2024-38942541,
  author  = {Shukla, Halak and John, Diana and Banerjee, Shuvomoy and Tiwari, Anand Krishna},
  title   = {{Drug repurposing for neurodegenerative diseases}},
  journal = {Progress in molecular biology and translational science},
  year    = {2024},
  doi     = {10.1016/bs.pmbts.2024.03.035},
  pmid    = {38942541},
  url     = {https://doi.org/10.1016/bs.pmbts.2024.03.035}
}

@article{song2024-38758223,
  author  = {Song, Tanya and Wang, Yunfei and Silverglate, Bret David and Grossberg, George T},
  title   = {{Pharmacokinetic evaluation of donanemab for the treatment of Alzheimer's}},
  journal = {Expert opinion on drug metabolism \& toxicology},
  year    = {2024},
  doi     = {10.1080/17425255.2024.2357637},
  pmid    = {38758223},
  url     = {https://doi.org/10.1080/17425255.2024.2357637}
}

@article{ramos2024-38674150,
  author  = {Ramos, Raquel and Vale, Nuno},
  title   = {{Dual Drug Repurposing: The Example of Saracatinib}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25084565},
  pmid    = {38674150},
  url     = {https://doi.org/10.3390/ijms25084565}
}

@article{thangwaritorn2024-38756263,
  author  = {Thangwaritorn, Skylynn and Lee, Christopher and Metchikoff, Elena and Razdan, Vidushi and Ghafary, Suliman and Rivera, Dominic and Pinto, Alvaro and Pemminati, Sudhakar},
  title   = {{A Review of Recent Advances in the Management of Alzheimer's Disease}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.58416},
  pmid    = {38756263},
  url     = {https://doi.org/10.7759/cureus.58416}
}

@article{mascarenhas2024-38840768,
  author  = {Mascarenhas, Lorraine and Downey, Michael and Schwartz, Gregory and Adabag, Selcuk},
  title   = {{Antiarrhythmic effects of metformin}},
  journal = {Heart rhythm O2},
  year    = {2024},
  doi     = {10.1016/j.hroo.2024.04.003},
  pmid    = {38840768},
  url     = {https://doi.org/10.1016/j.hroo.2024.04.003}
}

@article{hoilundcarlsen2024-38612701,
  author  = {Høilund-Carlsen, Poul F and Alavi, Abass and Castellani, Rudolph J and Neve, Rachael L and Perry, George and Revheim, Mona-Elisabeth and Barrio, Jorge R},
  title   = {{Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25073892},
  pmid    = {38612701},
  url     = {https://doi.org/10.3390/ijms25073892}
}

@article{schnell2024-38504284,
  author  = {Schnell, Oliver and Barnard-Kelly, Katharine and Battelino, Tadej and Ceriello, Antonio and Larsson, Helena Elding and Fernández-Fernández, Beatriz and Forst, Thomas and Frias, Juan-Pablo and others},
  title   = {{CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes}},
  journal = {Cardiovascular diabetology},
  year    = {2024},
  doi     = {10.1186/s12933-024-02180-8},
  pmid    = {38504284},
  url     = {https://doi.org/10.1186/s12933-024-02180-8}
}

@article{park2024-38932758,
  author  = {Park, Kyung Won},
  title   = {{Anti-amyloid Antibody Therapies for Alzheimer's Disease}},
  journal = {Nuclear medicine and molecular imaging},
  year    = {2024},
  doi     = {10.1007/s13139-024-00848-3},
  pmid    = {38932758},
  url     = {https://doi.org/10.1007/s13139-024-00848-3}
}

@article{adem2024-38255204,
  author  = {Adem, Muna A and Decourt, Boris and Sabbagh, Marwan N},
  title   = {{Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer's Disease}},
  journal = {Biomedicines},
  year    = {2024},
  doi     = {10.3390/biomedicines12010099},
  pmid    = {38255204},
  url     = {https://doi.org/10.3390/biomedicines12010099}
}

@article{crook2024-39422964,
  author  = {Crook, Harry and Edison, Paul},
  title   = {{Incretin Mimetics as Potential Disease Modifying Treatment for Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-240730},
  pmid    = {39422964},
  url     = {https://doi.org/10.3233/jad-240730}
}

@article{basso2024-37990896,
  author  = {Basso, Letícia and Fagundes, Silvia Cristina and Staudt, Tatiana and da Rosa, Karini and Langaro, Elizane and Omidian, Hamid and Bertol, Charise Dallazem},
  title   = {{Transdermal Therapeutic Systems for the Treatment of Alzheimer's Disease: A Patent Review}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2024},
  doi     = {10.2174/0118715273275957231102044934},
  pmid    = {37990896},
  url     = {https://doi.org/10.2174/0118715273275957231102044934}
}

@article{rohilla2024-38629171,
  author  = {Rohilla, Ankur and Rohilla, Seema},
  title   = {{Drug Repositioning: A Monetary Stratagem to Discover a New Application of Drugs}},
  journal = {Current drug discovery technologies},
  year    = {2024},
  doi     = {10.2174/0115701638253929230922115127},
  pmid    = {38629171},
  url     = {https://doi.org/10.2174/0115701638253929230922115127}
}

@article{niidome2024-38692883,
  author  = {Niidome, Tetsuhiro and Ishikawa, Yukio and Ogawa, Tomoo and Nakagawa, Masaki and Nakamura, Yosuke},
  title   = {{[Mechanism of action and clinical trial results of Lecanemab (Leqembi® 200 ‍mg, 500 ‍mg for Intravenous Infusion), a novel treatment for Alzheimer's disease]}},
  journal = {Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year    = {2024},
  doi     = {10.1254/fpj.24005},
  pmid    = {38692883},
  url     = {https://doi.org/10.1254/fpj.24005}
}

@article{kaur2024-38095822,
  author  = {Kaur, Upinder and Reddy, Jaideep and Tiwari, Ashutosh and Chakrabarti, Sasanka and Chakrabarti, Sankha Shubhra},
  title   = {{Lecanemab: More Questions Than Answers!}},
  journal = {Clinical drug investigation},
  year    = {2024},
  doi     = {10.1007/s40261-023-01331-1},
  pmid    = {38095822},
  url     = {https://doi.org/10.1007/s40261-023-01331-1}
}

@article{lu2023-37936917,
  author  = {Lu, O. and Kouser, T. and Skylar-Scott, I. A.},
  title   = {{Alzheimer's disease and epilepsy: shared neuropathology guides current and future treatment strategies}},
  journal = {Frontiers in neurology},
  year    = {2023},
  doi     = {10.3389/fneur.2023.1241339},
  pmid    = {37936917},
  url     = {https://doi.org/10.3389/fneur.2023.1241339}
}

@article{kron2024-37708433,
  author  = {Kron, Jarrah O-Z J and Keenan, Ryan J and Hoyer, Daniel and Jacobson, Laura H},
  title   = {{Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease}},
  journal = {Annual review of pharmacology and toxicology},
  year    = {2024},
  doi     = {10.1146/annurev-pharmtox-040323-031929},
  pmid    = {37708433},
  url     = {https://doi.org/10.1146/annurev-pharmtox-040323-031929}
}

@article{ramanan2023-37495380,
  author  = {Ramanan, V. K. and Armstrong, M. J. and Choudhury, P. and Coerver, K. A. and Hamilton, R. H. and Klein, B. C. and Wolk, D. A. and Wessels, SR. and others},
  title   = {{Antiamyloid Monoclonal Antibody Therapy for Alzheimer Disease: Emerging Issues in Neurology}},
  journal = {Neurology},
  year    = {2023},
  doi     = {10.1212/wnl.0000000000207757},
  pmid    = {37495380},
  url     = {https://doi.org/10.1212/wnl.0000000000207757}
}

@article{yadollahikhales2023-37490245,
  author  = {Yadollahikhales, G. and Rojas, J. C.},
  title   = {{Anti-Amyloid Immunotherapies for Alzheimer's Disease: A 2023 Clinical Update}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2023},
  doi     = {10.1007/s13311-023-01405-0},
  pmid    = {37490245},
  url     = {https://doi.org/10.1007/s13311-023-01405-0}
}

@article{cummings2023-37060386,
  author  = {Cummings, J.},
  title   = {{Anti-Amyloid Monoclonal Antibodies are Transformative Treatments that Redefine Alzheimer's Disease Therapeutics}},
  journal = {Drugs},
  year    = {2023},
  doi     = {10.1007/s40265-023-01858-9},
  pmid    = {37060386},
  url     = {https://doi.org/10.1007/s40265-023-01858-9}
}

@article{brodtmann2023-36934371,
  author  = {Brodtmann, Amy G. and Darby, David and Oboudiyat, Carly and Mahoney, Colin and Le Heron, Campbell J. and Panegyres, Peter K. and Brew, Bruce J.},
  title   = {{Assessing preparedness for Alzheimer disease‐modifying therapies in Australasian health care systems}},
  journal = {The Medical Journal of Australia},
  year    = {2023},
  doi     = {10.5694/mja2.51880},
  pmid    = {36934371},
  url     = {https://doi.org/10.5694/mja2.51880}
}

@article{perneczky2023-36655336,
  author  = {Perneczky, R. and Jessen, F. and Grimmer, T. and Levin, J. and Flöel, A. and Peters, O. and Froelich, L.},
  title   = {{Anti-amyloid antibody therapies in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awad005},
  pmid    = {36655336},
  url     = {https://doi.org/10.1093/brain/awad005}
}

@article{giacobini2022-35289363,
  author  = {Giacobini, E. and Cuello, A. C. and Fisher, A.},
  title   = {{Reimagining cholinergic therapy for Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awac096},
  pmid    = {35289363},
  url     = {https://doi.org/10.1093/brain/awac096}
}

@article{pardomoreno2022-35745693,
  author  = {Pardo-Moreno, T. and González-Acedo, A. and Rivas-Domínguez, A. and García-Morales, V. and García-Cozar, F. J. and Ramos-Rodríguez, J. J. and Melguizo-Rodríguez, L.},
  title   = {{Therapeutic Approach to Alzheimer's Disease: Current Treatments and New Perspectives}},
  journal = {Pharmaceutics},
  year    = {2022},
  doi     = {10.3390/pharmaceutics14061117},
  pmid    = {35745693},
  url     = {https://doi.org/10.3390/pharmaceutics14061117}
}

@article{vaz2022-35611326,
  author  = {Vaz, M. and Silva, V. and Monteiro, C. and Silvestre, S.},
  title   = {{Role of Aducanumab in the Treatment of Alzheimer's Disease: Challenges and Opportunities}},
  journal = {Clinical interventions in aging},
  year    = {2022},
  doi     = {10.2147/cia.s325026},
  pmid    = {35611326},
  url     = {https://doi.org/10.2147/cia.s325026}
}

@article{shi2022-35493943,
  author  = {Shi, M. and Chu, F. and Zhu, F. and Zhu, J.},
  title   = {{Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer's Disease: A Focus on Aducanumab and Lecanemab}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.870517},
  pmid    = {35493943},
  url     = {https://doi.org/10.3389/fnagi.2022.870517}
}

@article{retout2022-35100444,
  author  = {Retout, S. and Gieschke, R. and Serafin, D. and Weber, C. and Frey, N. and Hofmann, C.},
  title   = {{Disease Modeling and Model-Based Meta-Analyses to Define a New Direction for a Phase III Program of Gantenerumab in Alzheimer's Disease}},
  journal = {Clinical pharmacology and therapeutics},
  year    = {2022},
  doi     = {10.1002/cpt.2535},
  pmid    = {35100444},
  url     = {https://doi.org/10.1002/cpt.2535}
}

@article{cummings2022-35542993,
  author  = {Cummings, J. and Rabinovici, G. D. and Atri, A. and Aisen, P. and Apostolova, L. G. and Hendrix, S. and Sabbagh, M. and Selkoe, D. and others},
  title   = {{Aducanumab: Appropriate Use Recommendations Update}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2022},
  doi     = {10.14283/jpad.2022.34},
  pmid    = {35542993},
  url     = {https://doi.org/10.14283/jpad.2022.34}
}

@article{golde2022-35229269,
  author  = {Golde, T. E.},
  title   = {{Disease-Modifying Therapies for Alzheimer's Disease: More Questions than Answers}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2022},
  doi     = {10.1007/s13311-022-01201-2},
  pmid    = {35229269},
  url     = {https://doi.org/10.1007/s13311-022-01201-2}
}

@article{tampi2021-34650610,
  author  = {Tampi, R. R. and Forester, B. P. and Agronin, M.},
  title   = {{Aducanumab: evidence from clinical trial data and controversies}},
  journal = {Drugs in context},
  year    = {2021},
  doi     = {10.7573/dic.2021-7-3},
  pmid    = {34650610},
  url     = {https://doi.org/10.7573/dic.2021-7-3}
}

@article{yu2021-34360973,
  author  = {Yu, T. W. and Lane, H. Y. and Lin, C. H.},
  title   = {{Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22158208},
  pmid    = {34360973},
  url     = {https://doi.org/10.3390/ijms22158208}
}

@article{athar2021-34181171,
  author  = {Athar, T. and Al Balushi, K. and Khan, S. A.},
  title   = {{Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease}},
  journal = {Molecular biology reports},
  year    = {2021},
  doi     = {10.1007/s11033-021-06512-9},
  pmid    = {34181171},
  url     = {https://doi.org/10.1007/s11033-021-06512-9}
}

@article{cummings2021-34585212,
  author  = {Cummings, J. and Aisen, P. and Apostolova, L. G. and Atri, A. and Salloway, S. and Weiner, M.},
  title   = {{Aducanumab: Appropriate Use Recommendations}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2021},
  doi     = {10.14283/jpad.2021.41},
  pmid    = {34585212},
  url     = {https://doi.org/10.14283/jpad.2021.41}
}

@article{lowe2021-3ffcda2a,
  author  = {Lowe, Stephen Loucian and Willis, Brian A. and Hawdon, Anne and Natanegara, Fanni and Chua, Laiyi and Foster, Joanne and Shcherbinin, Sergey and Ardayfio, Paul and others},
  title   = {{Donanemab (LY3002813) dose‐escalation study in Alzheimer's disease}},
  journal = {Alzheimer's \& Dementia: Translational Research \& Clinical Interventions},
  year    = {2021},
  doi     = {10.1002/trc2.12112},
  url     = {https://doi.org/10.1002/trc2.12112}
}

@article{knopman2021-33135381,
  author  = {Knopman, D. S. and Jones, D. T. and Greicius, M. D.},
  title   = {{Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12213},
  pmid    = {33135381},
  url     = {https://doi.org/10.1002/alz.12213}
}

@article{vandevrede2020-33072846,
  author  = {VandeVrede, Lawren and Gibbs, Daniel M and Koestler, Mary and La Joie, Renaud and Ljubenkov, Peter A and Provost, Karine and Soleimani-Meigooni, David and Strom, Amelia and others},
  title   = {{Symptomatic amyloid-related imaging abnormalities in an APOE ε4/ε4 patient treated with aducanumab}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2020},
  doi     = {10.1002/dad2.12101},
  pmid    = {33072846},
  url     = {https://doi.org/10.1002/dad2.12101}
}

@article{armstrong2020-32044947,
  author  = {Armstrong, M. J. and Okun, M. S.},
  title   = {{Diagnosis and Treatment of Parkinson Disease: A Review}},
  journal = {JAMA},
  year    = {2020},
  doi     = {10.1001/jama.2019.22360},
  pmid    = {32044947},
  url     = {https://doi.org/10.1001/jama.2019.22360}
}

@article{barthold2020-32538845,
  author  = {Barthold, Douglas and Joyce, Geoffrey and Ferido, Patricia and Drabo, Emmanuel F and Marcum, Zachary A and Gray, Shelly L and Zissimopoulos, Julie},
  title   = {{Pharmaceutical Treatment for Alzheimer's Disease and Related Dementias: Utilization and Disparities}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200133},
  pmid    = {32538845},
  url     = {https://doi.org/10.3233/jad-200133}
}

@article{willis2018-30511011,
  author  = {Willis, Brian A and Sundell, Karen and Lachno, D Richard and Ferguson-Sells, Lisa R and Case, Michael G and Holdridge, Karen and DeMattos, Ronald B and Raskin, Joel and others},
  title   = {{Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2018},
  doi     = {10.1016/j.trci.2018.10.001},
  pmid    = {30511011},
  url     = {https://doi.org/10.1016/j.trci.2018.10.001}
}

@article{gold2017-29067346,
  author  = {Gold, Michael},
  title   = {{Phase II clinical trials of anti-amyloid β antibodies: When is enough, enough?}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2017},
  doi     = {10.1016/j.trci.2017.04.005},
  pmid    = {29067346},
  url     = {https://doi.org/10.1016/j.trci.2017.04.005}
}

@article{zimmerman2017-27546477,
  author  = {Zimmerman, Mark and Multach, Matthew D and Clark, Heather L and Walsh, Emily and Rosenstein, Lia K and Gazarian, Douglas},
  title   = {{Inclusion/exclusion criteria in late life depression antidepressant efficacy trials}},
  journal = {International journal of geriatric psychiatry},
  year    = {2017},
  doi     = {10.1002/gps.4560},
  pmid    = {27546477},
  url     = {https://doi.org/10.1002/gps.4560}
}

@article{sevigny2015-204cb97e,
  author  = {Sevigny, Jeff and Chiao, Ping and Williams, Leslie J. and Chen, Tianle and Ling, Yan and O'Gorman, John and Höck, Christoph and Nitsch, Roger M. and others},
  title   = {{O4‐04‐05: Aducanumab (BIIB037), an anti‐amyloid beta monoclonal antibody, in patients with prodromal or mild Alzheimer's disease: Interim results of a randomized, double‐blind, placebo‐controlled, phase 1b study}},
  journal = {Alzheimer s \& Dementia},
  year    = {2015},
  doi     = {10.1016/j.jalz.2015.07.367},
  url     = {https://doi.org/10.1016/j.jalz.2015.07.367}
}

@article{tanskanen2015-25890003,
  author  = {Tanskanen, A. and Taipale, H. and Koponen, M. and Tolppanen, A. M. and Hartikainen, S. and Ahonen, R. and Tiihonen, J.},
  title   = {{From prescription drug purchases to drug use periods – a second generation method (PRE2DUP)}},
  journal = {BMC medical informatics and decision making},
  year    = {2015},
  doi     = {10.1186/s12911-015-0140-z},
  pmid    = {25890003},
  url     = {https://doi.org/10.1186/s12911-015-0140-z}
}

@article{zack2015-2d3045db,
  author  = {Zack, Julia and Berg, Jolene and Juan, Axel and Pannacciulli, Nicola and Allard, Martine and Gottwald, Mildred and Zhang, Heather and Shao, Yongwu and others},
  title   = {{Pharmacokinetic drug–drug interaction study of ranolazine and metformin in subjects with type 2 diabetes mellitus}},
  journal = {Clinical Pharmacology in Drug Development},
  year    = {2015},
  doi     = {10.1002/cpdd.174},
  url     = {https://doi.org/10.1002/cpdd.174}
}

@article{cummings2014-25024750,
  author  = {Cummings, J. L. and Morstorf, T. and Zhong, K.},
  title   = {{Alzheimer's disease drug-development pipeline: few candidates, frequent failures}},
  journal = {Alzheimer's research \& therapy},
  year    = {2014},
  doi     = {10.1186/alzrt269},
  pmid    = {25024750},
  url     = {https://doi.org/10.1186/alzrt269}
}

@article{greig2014-24529527,
  author  = {Greig, N. H. and Tweedie, D. and Rachmany, L. and Li, Y. and Rubovitch, V. and Schreiber, S. and Chiang, Y. H. and Hoffer, B. J. and others},
  title   = {{Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2014},
  doi     = {10.1016/j.jalz.2013.12.011},
  pmid    = {24529527},
  url     = {https://doi.org/10.1016/j.jalz.2013.12.011}
}

@article{kornhuber2011-21909365,
  author  = {Kornhuber, J. and Muehlbacher, M. and Trapp, S. and Pechmann, S. and Friedl, A. and Reichel, M. and Mühle, C. and Terfloth, L. and others},
  title   = {{Identification of novel functional inhibitors of acid sphingomyelinase}},
  journal = {PloS one},
  year    = {2011},
  doi     = {10.1371/journal.pone.0023852},
  pmid    = {21909365},
  url     = {https://doi.org/10.1371/journal.pone.0023852}
}

@article{siemers2010-20375655,
  author  = {Siemers, E. R. and Friedrich, S. and Dean, R. A. and Gonzales, C. R. and Farlow, M. R. and Paul, S. M. and Demattos, R. B.},
  title   = {{Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease}},
  journal = {Clinical neuropharmacology},
  year    = {2010},
  doi     = {10.1097/wnf.0b013e3181cb577a},
  pmid    = {20375655},
  url     = {https://doi.org/10.1097/wnf.0b013e3181cb577a}
}

@article{giuffrida2004-15354183,
  author  = {Giuffrida, A. and Leweke, F. M. and Gerth, C. W. and Schreiber, D. and Koethe, D. and Faulhaber, J. and Klosterkötter, J. and Piomelli, D.},
  title   = {{Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2004},
  doi     = {10.1038/sj.npp.1300558},
  pmid    = {15354183},
  url     = {https://doi.org/10.1038/sj.npp.1300558}
}

@article{sjogren2001-11475012,
  author  = {Sjögren, M and Hesse, C and Basun, H and Köl, G and Thostrup, H and Kilander, L and Marcusson, J and Edman, A and others},
  title   = {{Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2001},
  doi     = {10.1007/s007020170066},
  pmid    = {11475012},
  url     = {https://doi.org/10.1007/s007020170066}
}

@article{mega1999-10555660,
  author  = {Mega, M. S. and Masterman, D. M. and O'Connor, S. M. and Barclay, T. R. and Cummings, J. L.},
  title   = {{The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {1999},
  doi     = {10.1001/archneur.56.11.1388},
  pmid    = {10555660},
  url     = {https://doi.org/10.1001/archneur.56.11.1388}
}

@article{nyth1990-1705151,
  author  = {Nyth, Anna Lena and Gottfries, Carl Gerhard},
  title   = {{The Clinical Efficacy of Citalopram in Treatment of Emotional Disturbances in Dementia Disorders a Nordic Multicentre Study}},
  journal = {The British Journal of Psychiatry},
  year    = {1990},
  doi     = {10.1192/bjp.157.6.894},
  pmid    = {1705151},
  url     = {https://doi.org/10.1192/bjp.157.6.894}
}

@article{christie1981-7023592,
  author  = {CHRISTIE, JANICE E. and Shering, A. and Ferguson, James M. and Glen, A.I.M.},
  title   = {{Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia}},
  journal = {The British Journal of Psychiatry},
  year    = {1981},
  doi     = {10.1192/bjp.138.1.46},
  pmid    = {7023592},
  url     = {https://doi.org/10.1192/bjp.138.1.46}
}

@article{khorshid2026-2ca036da,
  author  = {Khorshid, R. and Binyamin, M. and Alsalem, M.},
  title   = {{Case Report: SIADH-Induced Hyponatremia Following Sertraline and Quetiapine Use in an Elderly Patient with Dementia: A Case Report}},
  journal = {F1000Res},
  year    = {2026},
  doi     = {10.12688/f1000research.182914.1},
  url     = {https://doi.org/10.12688/f1000research.182914.1}
}

@article{guo2025-41107537,
  author  = {Guo, X. and Yue, R. and Cui, Z. and Wang, S. and Jia, T. and Li, W. and Zhang, W. and Shan, L. and others},
  title   = {{Advances of therapeutic strategies for Alzheimer's disease}},
  journal = {Journal of neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13456-8},
  pmid    = {41107537},
  url     = {https://doi.org/10.1007/s00415-025-13456-8}
}

@article{elamin2025-41077117,
  author  = {Elamin, S. A. and Al Shibli, A. N. and Shaito, A. and Al-Maadhadi, M. J. M. B. and Zolezzi, M. and Pedersen, S.},
  title   = {{Anti-amyloid monoclonal antibody therapies in Alzheimer's disease - a scoping review}},
  journal = {Neuroscience},
  year    = {2025},
  doi     = {10.1016/j.neuroscience.2025.10.011},
  pmid    = {41077117},
  url     = {https://doi.org/10.1016/j.neuroscience.2025.10.011}
}

@article{francis2025-40940304,
  author  = {Francis, E. and Paylor, S. and Van, C. and Mathews, B. and Sobhanian, M. J. and Mansour, D. Z. and Hennawi, G. and Brandt, N. J.},
  title   = {{Review of anti-amyloid-beta (Aβ) monoclonal antibodies for the treatment of Alzheimer's disease}},
  journal = {Expert review of clinical pharmacology},
  year    = {2025},
  doi     = {10.1080/17512433.2025.2556122},
  pmid    = {40940304},
  url     = {https://doi.org/10.1080/17512433.2025.2556122}
}

@article{daly2024-39698778,
  author  = {Daly, T. and Olluri, A. and Kurkinen, M.},
  title   = {{Anti-amyloid treatments in Alzheimer's disease: elegance, evidence and ethics}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2024},
  doi     = {10.17219/acem/198674},
  pmid    = {39698778},
  url     = {https://doi.org/10.17219/acem/198674}
}

@article{thussu2024-39291991,
  author  = {Thussu, S. and Naidu, A. and Manivannan, S. and Grossberg, G. T.},
  title   = {{Profiling aducanumab as a treatment option for Alzheimer's disease: an overview of efficacy, safety and tolerability}},
  journal = {Expert review of neurotherapeutics},
  year    = {2024},
  doi     = {10.1080/14737175.2024.2402058},
  pmid    = {39291991},
  url     = {https://doi.org/10.1080/14737175.2024.2402058}
}

@article{doggrell2024-38414336,
  author  = {Doggrell, S. A.},
  title   = {{More failure with solanezumab - this time in preclinical Alzheimer's disease}},
  journal = {Expert opinion on biological therapy},
  year    = {2024},
  doi     = {10.1080/14712598.2024.2325551},
  pmid    = {38414336},
  url     = {https://doi.org/10.1080/14712598.2024.2325551}
}

@article{singh2024-38286338,
  author  = {Singh, B. and Day, C. M. and Abdella, S. and Garg, S.},
  title   = {{Alzheimer's disease current therapies, novel drug delivery systems and future directions for better disease management}},
  journal = {Journal of controlled release : official journal of the Controlled Release Society},
  year    = {2024},
  doi     = {10.1016/j.jconrel.2024.01.047},
  pmid    = {38286338},
  url     = {https://doi.org/10.1016/j.jconrel.2024.01.047}
}

@article{zhang2023-38273821,
  author  = {Zhang, Ni and Gan, Lanlan and Xiang, Guiyuan and Xu, Jing and Jiang, Tingting and Li, Yanping and Wu, Yuanlin and Ni, Rui and others},
  title   = {{Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study}},
  journal = {Frontiers in pharmacology},
  year    = {2023},
  doi     = {10.3389/fphar.2023.1343650},
  pmid    = {38273821},
  url     = {https://doi.org/10.3389/fphar.2023.1343650}
}

@article{sotoudeh2023-38249159,
  author  = {Sotoudeh, Houman and Alizadeh, Mohammadreza and Shahidi, Ramin and Shobeiri, Parnian and Saadatpour, Zahra and Wheeler, C Austin and Love, Marissa Natelson and Tanwar, Manoj},
  title   = {{Imaging spectrum of amyloid-related imaging abnormalities associated with aducanumab immunotherapy}},
  journal = {Frontiers in radiology},
  year    = {2023},
  doi     = {10.3389/fradi.2023.1305390},
  pmid    = {38249159},
  url     = {https://doi.org/10.3389/fradi.2023.1305390}
}

@article{espay2024-38701151,
  author  = {Espay, A. J. and Herrup, K. and Imbimbo, B. P. and Kepp, K. P. and Daly, T.},
  title   = {{Recalibrating the Risk-Benefit Profiles of Lecanemab and Donanemab: Scales, Immunoreactivity, and Changes in Amyloid-β42}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-240171},
  pmid    = {38701151},
  url     = {https://doi.org/10.3233/jad-240171}
}

@article{hafiz2023-38222245,
  author  = {Hafiz, Rehab and Alajlani, Lama and Ali, Albatool and Algarni, Ghadah A and Aljurfi, Hassan and Alammar, Omar Abdullah M and Ashqan, Maria Y and Alkhashan, Alanoud},
  title   = {{The Latest Advances in the Diagnosis and Treatment of Dementia}},
  journal = {Cureus},
  year    = {2023},
  doi     = {10.7759/cureus.50522},
  pmid    = {38222245},
  url     = {https://doi.org/10.7759/cureus.50522}
}

@article{defreitas2023-37971177,
  author  = {de Freitas, Evani Leite and Calil-Elias, Sabrina and Erbisti, Rafael Santos and Grinberg-Weller, Branca and Miranda, Elaine Silva},
  title   = {{Consumption of drugs for Alzheimer's disease on the Brazilian private market}},
  journal = {Revista de saude publica},
  year    = {2023},
  doi     = {10.11606/s1518-8787.2023057005128},
  pmid    = {37971177},
  url     = {https://doi.org/10.11606/s1518-8787.2023057005128}
}

@article{kieu2023-38487381,
  author  = {Kieu, Chinh and Look, Kevin A},
  title   = {{Cost-Effectiveness of a Hypothetical Gene Therapy for Alzheimer's Disease: A Markov Simulation Analysis}},
  journal = {Innovations in pharmacy},
  year    = {2023},
  doi     = {10.24926/iip.v14i3.5500},
  pmid    = {38487381},
  url     = {https://doi.org/10.24926/iip.v14i3.5500}
}

@article{varadharajan2023-38059250,
  author  = {Varadharajan, Ashvin and Davis, Aarjith Damian and Ghosh, Aishwarya and Jagtap, Tejaswini and Xavier, Anjo and Menon, Anjana Jayakumar and Roy, Dwaiti and Gandhi, Sandhya and others},
  title   = {{Guidelines for pharmacotherapy in Alzheimer's disease - A primer on FDA-approved drugs}},
  journal = {Journal of neurosciences in rural practice},
  year    = {2023},
  doi     = {10.25259/jnrp_356_2023},
  pmid    = {38059250},
  url     = {https://doi.org/10.25259/jnrp_356_2023}
}

@article{chowdhury2023-39726673,
  author  = {Chowdhury, Selia},
  title   = {{Monoclonal Antibody Treatments for Alzheimer's Disease: Aducanumab and Lecanemab}},
  journal = {Discoveries (Craiova, Romania)},
  year    = {2023},
  doi     = {10.15190/d.2023.12},
  pmid    = {39726673},
  url     = {https://doi.org/10.15190/d.2023.12}
}

@article{fedele2023-37833948,
  author  = {Fedele, Ernesto},
  title   = {{Anti-Amyloid Therapies for Alzheimer's Disease and the Amyloid Cascade Hypothesis}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms241914499},
  pmid    = {37833948},
  url     = {https://doi.org/10.3390/ijms241914499}
}

@article{basagni2023-37734258,
  author  = {Basagni, Filippo and Ortega, Jose A and Bertozzi, Sine M and Armirotti, Andrea and Summa, Maria and Bertorelli, Rosalia and Bartolini, Manuela and Mellor, Ian R and others},
  title   = {{Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties}},
  journal = {European journal of medicinal chemistry},
  year    = {2023},
  doi     = {10.1016/j.ejmech.2023.115803},
  pmid    = {37734258},
  url     = {https://doi.org/10.1016/j.ejmech.2023.115803}
}

@article{singh2023-37694498,
  author  = {Singh, Yash Pal and Kumar, Navneet and Chauhan, Brijesh Singh and Garg, Prabha},
  title   = {{Carbamate as a potential anti-Alzheimer's pharmacophore: A review}},
  journal = {Drug development research},
  year    = {2023},
  doi     = {10.1002/ddr.22113},
  pmid    = {37694498},
  url     = {https://doi.org/10.1002/ddr.22113}
}

@article{zhang2023-37682322,
  author  = {Zhang, Jinwei},
  title   = {{Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer's disease treatment}},
  journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]},
  year    = {2023},
  doi     = {10.1007/s00011-023-01788-y},
  pmid    = {37682322},
  url     = {https://doi.org/10.1007/s00011-023-01788-y}
}

@article{singh2023-37675624,
  author  = {Singh, Yash P and Kumar, Harish},
  title   = {{Tryptamine: A privileged scaffold for the management of Alzheimer's disease}},
  journal = {Drug development research},
  year    = {2023},
  doi     = {10.1002/ddr.22111},
  pmid    = {37675624},
  url     = {https://doi.org/10.1002/ddr.22111}
}

@article{kurkinen2023-37676096,
  author  = {Kurkinen, Markku},
  title   = {{Lecanemab (Leqembi) is not the right drug for patients with Alzheimer's disease}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2023},
  doi     = {10.17219/acem/171379},
  pmid    = {37676096},
  url     = {https://doi.org/10.17219/acem/171379}
}

@article{devanand2023-37639488,
  author  = {Devanand, D P},
  title   = {{Management of neuropsychiatric symptoms in dementia}},
  journal = {Current opinion in neurology},
  year    = {2023},
  doi     = {10.1097/wco.0000000000001199},
  pmid    = {37639488},
  url     = {https://doi.org/10.1097/wco.0000000000001199}
}

@article{adelman2023-37381137,
  author  = {Adelman, Megan and Louis, Lora},
  title   = {{A Novel Formulation: Donepezil Patch}},
  journal = {The Senior care pharmacist},
  year    = {2023},
  doi     = {10.4140/tcp.n.2023.300},
  pmid    = {37381137},
  url     = {https://doi.org/10.4140/tcp.n.2023.300}
}

@article{jonsson2023-37251789,
  author  = {Jönsson, Linus and Wimo, Anders and Handels, Ron and Johansson, Gunilla and Boada, Mercè and Engelborghs, Sebastiaan and Frölich, Lutz and Jessen, Frank and others},
  title   = {{The affordability of lecanemab, an amyloid-targeting therapy for Alzheimer's disease: an EADC-EC viewpoint}},
  journal = {The Lancet regional health. Europe},
  year    = {2023},
  doi     = {10.1016/j.lanepe.2023.100657},
  pmid    = {37251789},
  url     = {https://doi.org/10.1016/j.lanepe.2023.100657}
}

@article{bayraktar2023-37210557,
  author  = {Bayraktar, Abdulahad and Li, Xiangyu and Kim, Woonghee and Zhang, Cheng and Turkez, Hasan and Shoaie, Saeed and Mardinoglu, Adil},
  title   = {{Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients}},
  journal = {Journal of translational medicine},
  year    = {2023},
  doi     = {10.1186/s12967-023-04192-6},
  pmid    = {37210557},
  url     = {https://doi.org/10.1186/s12967-023-04192-6}
}

@article{baba2023-38868144,
  author  = {Baba, Hajime},
  title   = {{Treatment strategy for late-life depression}},
  journal = {PCN reports : psychiatry and clinical neurosciences},
  year    = {2023},
  doi     = {10.1002/pcn5.91},
  pmid    = {38868144},
  url     = {https://doi.org/10.1002/pcn5.91}
}

@article{yamada2023-37194514,
  author  = {Yamada, Masahito},
  title   = {{[Anti-Dementia Drugs (Anti-Alzheimer's Disease Drugs)]}},
  journal = {Brain and nerve = Shinkei kenkyu no shinpo},
  year    = {2023},
  doi     = {10.11477/mf.1416202360},
  pmid    = {37194514},
  url     = {https://doi.org/10.11477/mf.1416202360}
}

@article{kassa2023-37051629,
  author  = {Kassa, Jiri and Karasova, Jana Zdarova},
  title   = {{Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice}},
  journal = {Toxicology mechanisms and methods},
  year    = {2023},
  doi     = {10.1080/15376516.2023.2202730},
  pmid    = {37051629},
  url     = {https://doi.org/10.1080/15376516.2023.2202730}
}

@article{alkuraishy2023-36849855,
  author  = {Al-Kuraishy, Hayder M and Al-Gareeb, Ali I and Saad, Hebatallah M and Batiha, Gaber El-Saber},
  title   = {{Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects}},
  journal = {Inflammopharmacology},
  year    = {2023},
  doi     = {10.1007/s10787-023-01163-7},
  pmid    = {36849855},
  url     = {https://doi.org/10.1007/s10787-023-01163-7}
}

@article{jimenez2023-36677633,
  author  = {Jiménez, Elvia Mera and Żołek, Teresa and Perez, Paola Gabriela Hernández and Ruvalcaba, Rene Miranda and Nicolás-Vázquez, María Inés and Hernández-Rodríguez, Maricarmen},
  title   = {{Drug Repurposing to Inhibit Histamine N-Methyl Transferase}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/molecules28020576},
  pmid    = {36677633},
  url     = {https://doi.org/10.3390/molecules28020576}
}

@article{kepp2023-37334596,
  author  = {Kepp, Kasper P and Sensi, Stefano L and Johnsen, Kasper B and Barrio, Jorge R and Høilund-Carlsen, Poul F and Neve, Rachael L and Alavi, Abass and Herrup, Karl and others},
  title   = {{The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2023},
  doi     = {10.3233/jad-230099},
  pmid    = {37334596},
  url     = {https://doi.org/10.3233/jad-230099}
}

@article{gauthier2023-37357267,
  author  = {Gauthier, S and Ismail, Z and Goodarzi, Z and Ng, K P and Rosa-Neto, P},
  title   = {{Viewpoint: Clinicians' Perspectives on How Disease Modifying Drugs for Alzheimer's Disease Impact Specialty Care}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2023},
  doi     = {10.14283/jpad.2023.72},
  pmid    = {37357267},
  url     = {https://doi.org/10.14283/jpad.2023.72}
}

@article{agarwal2023-35733313,
  author  = {Agarwal, Kritie and Katare, Deepshikha Pande and Jakhmola-Mani, Ruchi},
  title   = {{Foresee Novel Targets for Alzheimer's Disease by Investigating Repurposed Drugs}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2023},
  doi     = {10.2174/1871527321666220622162622},
  pmid    = {35733313},
  url     = {https://doi.org/10.2174/1871527321666220622162622}
}

@article{nijskens2023-37125555,
  author  = {Nijskens, Charlotte and Henstra, Marieke and Rhodius-Meester, Hanneke and Yasar, Sevil and van Poelgeest, Eveline and Peters, Mike and Muller, Majon},
  title   = {{Cardiovascular Risk Management in Persons with Dementia}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2023},
  doi     = {10.3233/jad-230019},
  pmid    = {37125555},
  url     = {https://doi.org/10.3233/jad-230019}
}

@article{naseri2023-36474458,
  author  = {Naseri, Amirreza and Sanaie, Sarvin and Hamzehzadeh, Sina and Seyedi-Sahebari, Sepideh and Hosseini, Mohammad-Salar and Gholipour-Khalili, Elnaz and Rezazadeh-Gavgani, Ehsan and Majidazar, Reza and others},
  title   = {{Metformin: new applications for an old drug}},
  journal = {Journal of basic and clinical physiology and pharmacology},
  year    = {2023},
  doi     = {10.1515/jbcpp-2022-0252},
  pmid    = {36474458},
  url     = {https://doi.org/10.1515/jbcpp-2022-0252}
}

@article{bateman2022-36447240,
  author  = {Bateman, Randall J and Cummings, Jeffrey and Schobel, Scott and Salloway, Stephen and Vellas, Bruno and Boada, Mercè and Black, Sandra E and Blennow, Kaj and others},
  title   = {{Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2022},
  doi     = {10.1186/s13195-022-01110-8},
  pmid    = {36447240},
  url     = {https://doi.org/10.1186/s13195-022-01110-8}
}

@article{nunes2022-36365114,
  author  = {Nunes, Débora and Loureiro, Joana A and Pereira, Maria Carmo},
  title   = {{Drug Delivery Systems as a Strategy to Improve the Efficacy of FDA-Approved Alzheimer's Drugs}},
  journal = {Pharmaceutics},
  year    = {2022},
  doi     = {10.3390/pharmaceutics14112296},
  pmid    = {36365114},
  url     = {https://doi.org/10.3390/pharmaceutics14112296}
}

@article{savelieff2022-36240668,
  author  = {Savelieff, Masha G and Chen, Kevin S and Elzinga, Sarah E and Feldman, Eva L},
  title   = {{Diabetes and dementia: Clinical perspective, innovation, knowledge gaps}},
  journal = {Journal of diabetes and its complications},
  year    = {2022},
  doi     = {10.1016/j.jdiacomp.2022.108333},
  pmid    = {36240668},
  url     = {https://doi.org/10.1016/j.jdiacomp.2022.108333}
}

@article{kakoti2022-36263141,
  author  = {Kakoti, Bibhuti Bhusan and Bezbaruah, Rajashri and Ahmed, Nasima},
  title   = {{Therapeutic drug repositioning with special emphasis on neurodegenerative diseases: Threats and issues}},
  journal = {Frontiers in pharmacology},
  year    = {2022},
  doi     = {10.3389/fphar.2022.1007315},
  pmid    = {36263141},
  url     = {https://doi.org/10.3389/fphar.2022.1007315}
}

@article{zhu2022-35765655,
  author  = {Zhu, Sha and Bai, Qifeng and Li, Lanqing and Xu, Tingyang},
  title   = {{Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents}},
  journal = {Computational and structural biotechnology journal},
  year    = {2022},
  doi     = {10.1016/j.csbj.2022.05.057},
  pmid    = {35765655},
  url     = {https://doi.org/10.1016/j.csbj.2022.05.057}
}

@article{villain2022-35489824,
  author  = {Villain, N},
  title   = {{Therapeutic news in Alzheimer's disease: Soon a disease-modifying therapy?}},
  journal = {Revue neurologique},
  year    = {2022},
  doi     = {10.1016/j.neurol.2022.02.456},
  pmid    = {35489824},
  url     = {https://doi.org/10.1016/j.neurol.2022.02.456}
}

@article{rybakowski2022-35364656,
  author  = {Rybakowski, Janusz K},
  title   = {{Antiviral, immunomodulatory, and neuroprotective effect of lithium}},
  journal = {Journal of integrative neuroscience},
  year    = {2022},
  doi     = {10.31083/j.jin2102068},
  pmid    = {35364656},
  url     = {https://doi.org/10.31083/j.jin2102068}
}

@article{cacabelos2022-35330211,
  author  = {Cacabelos, Ramón and Naidoo, Vinogran and Martínez-Iglesias, Olaia and Corzo, Lola and Cacabelos, Natalia and Pego, Rocío and Carril, Juan C},
  title   = {{Personalized Management and Treatment of Alzheimer's Disease}},
  journal = {Life (Basel, Switzerland)},
  year    = {2022},
  doi     = {10.3390/life12030460},
  pmid    = {35330211},
  url     = {https://doi.org/10.3390/life12030460}
}

@article{savva2022-35386099,
  author  = {Savva, Kyriaki and Zachariou, Margarita and Bourdakou, Marilena M and Dietis, Nikolas and Spyrou, George M},
  title   = {{Network-based stage-specific drug repurposing for Alzheimer's disease}},
  journal = {Computational and structural biotechnology journal},
  year    = {2022},
  doi     = {10.1016/j.csbj.2022.03.013},
  pmid    = {35386099},
  url     = {https://doi.org/10.1016/j.csbj.2022.03.013}
}

@article{haddad2022-35928986,
  author  = {Haddad, Hannah W and Malone, Garett W and Comardelle, Nicholas J and Degueure, Arielle E and Kaye, Adam M and Kaye, Alan D},
  title   = {{Aducanumab, a Novel Anti-Amyloid Monoclonal Antibody, for the Treatment of Alzheimer's Disease: A Comprehensive Review}},
  journal = {Health psychology research},
  year    = {2022},
  doi     = {10.52965/001c.31925},
  pmid    = {35928986},
  url     = {https://doi.org/10.52965/001c.31925}
}

@article{jacobson2022-35043499,
  author  = {Jacobson, Laura H and Hoyer, Daniel and de Lecea, Luis},
  title   = {{Hypocretins (orexins): The ultimate translational neuropeptides}},
  journal = {Journal of internal medicine},
  year    = {2022},
  doi     = {10.1111/joim.13406},
  pmid    = {35043499},
  url     = {https://doi.org/10.1111/joim.13406}
}

@article{sivaraman2022-34602041,
  author  = {Sivaraman, Bhuvaneswari and Raji, Vijaykumar and Velmurugan, Bala Aakash and Natarajan, Ramalakshmi},
  title   = {{Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2022},
  doi     = {10.2174/1871527320666210928160159},
  pmid    = {34602041},
  url     = {https://doi.org/10.2174/1871527320666210928160159}
}

@article{bu2022-35964196,
  author  = {Bu, Kun and Patel, Devashru and Morris, Robert and Han, Weiru and Umeukeje, Gibret and Zhu, Tianrui and Cheng, Feng},
  title   = {{Dysphagia Risk in Patients Prescribed Rivastigmine: A Systematic Analysis of FDA Adverse Event Reporting System}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220583},
  pmid    = {35964196},
  url     = {https://doi.org/10.3233/jad-220583}
}

@article{daly2022-35001895,
  author  = {Daly, Timothy and Mastroleo, Ignacio and Henry, Vincent and Bourdenx, Mathieu},
  title   = {{An Argument for Simple Tests of Treatment of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-215492},
  pmid    = {35001895},
  url     = {https://doi.org/10.3233/jad-215492}
}

@article{daly2022-35275544,
  author  = {Daly, Timothy and Mastroleo, Ignacio and Migliaccio, Raffaella},
  title   = {{Avoiding Over-Reliance on Multi-Domain Interventions for Dementia Prevention}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-215647},
  pmid    = {35275544},
  url     = {https://doi.org/10.3233/jad-215647}
}

@article{iranzo2022-36217075,
  author  = {Iranzo, Alex},
  title   = {{An Overview on Sleep Medicine}},
  journal = {Advances in experimental medicine and biology},
  year    = {2022},
  doi     = {10.1007/978-3-031-06413-5_1},
  pmid    = {36217075},
  url     = {https://doi.org/10.1007/978-3-031-06413-5_1}
}

@article{synnott2021-34714106,
  author  = {Synnott, Patricia G and Whittington, Melanie D and Lin, Grace A and Rind, David M and Pearson, Steven D},
  title   = {{The effectiveness and value of aducanumab for Alzheimer's disease}},
  journal = {Journal of managed care \& specialty pharmacy},
  year    = {2021},
  doi     = {10.18553/jmcp.2021.27.11.1613},
  pmid    = {34714106},
  url     = {https://doi.org/10.18553/jmcp.2021.27.11.1613}
}

@article{kuang2021-33642368,
  author  = {Kuang, Huang and Zhu, Yu-Ge and Zhou, Zhi-Feng and Yang, Mei-Wen and Hong, Fen-Fang and Yang, Shu-Long},
  title   = {{Sleep disorders in Alzheimer's disease: the predictive roles and potential mechanisms}},
  journal = {Neural regeneration research},
  year    = {2021},
  doi     = {10.4103/1673-5374.308071},
  pmid    = {33642368},
  url     = {https://doi.org/10.4103/1673-5374.308071}
}

@article{wichniak2021-34994734,
  author  = {Wichniak, Adam and Wierzbicka, Aleksandra Ewa and Jarema, Marek},
  title   = {{Treatment of insomnia - effect of trazodone and hypnotics on sleep}},
  journal = {Psychiatria polska},
  year    = {2021},
  doi     = {10.12740/pp/125650},
  pmid    = {34994734},
  url     = {https://doi.org/10.12740/pp/125650}
}

@article{urbina2021-34274565,
  author  = {Urbina, Fabio and Puhl, Ana C and Ekins, Sean},
  title   = {{Recent advances in drug repurposing using machine learning}},
  journal = {Current opinion in chemical biology},
  year    = {2021},
  doi     = {10.1016/j.cbpa.2021.06.001},
  pmid    = {34274565},
  url     = {https://doi.org/10.1016/j.cbpa.2021.06.001}
}

@article{vargassoria2021-34118986,
  author  = {Vargas-Soria, Maria and Carranza-Naval, Maria Jose and Del Marco, Angel and Garcia-Alloza, Monica},
  title   = {{Role of liraglutide in Alzheimer's disease pathology}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00853-0},
  pmid    = {34118986},
  url     = {https://doi.org/10.1186/s13195-021-00853-0}
}

@article{haussmann2021-34119602,
  author  = {Haussmann, Robert and Noppes, Felix and Brandt, Moritz D and Bauer, Michael and Donix, Markus},
  title   = {{Lithium: A therapeutic option in Alzheimer's disease and its prodromal stages?}},
  journal = {Neuroscience letters},
  year    = {2021},
  doi     = {10.1016/j.neulet.2021.136044},
  pmid    = {34119602},
  url     = {https://doi.org/10.1016/j.neulet.2021.136044}
}

@article{ahmed2021-33915501,
  author  = {Ahmed, Sagheer and Khan, Sidrah Tariq and Zargaham, Muhammad Kazim and Khan, Arif Ullah and Khan, Saeed and Hussain, Abrar and Uddin, Jalal and Khan, Ajmal and others},
  title   = {{Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2021},
  doi     = {10.1016/j.biopha.2021.111609},
  pmid    = {33915501},
  url     = {https://doi.org/10.1016/j.biopha.2021.111609}
}

@article{sun2021-33920698,
  author  = {Sun, Chichun and Armstrong, Melissa J},
  title   = {{Treatment of Parkinson's Disease with Cognitive Impairment: Current Approaches and Future Directions}},
  journal = {Behavioral sciences (Basel, Switzerland)},
  year    = {2021},
  doi     = {10.3390/bs11040054},
  pmid    = {33920698},
  url     = {https://doi.org/10.3390/bs11040054}
}

@article{mayer2021-33691803,
  author  = {Mayer, Geert and Happe, Svenja and Evers, Stefan and Hermann, Wiebke and Jansen, Sabine and Kallweit, Ulf and Muntean, Maria-Lucia and Pöhlau, Dieter and others},
  title   = {{Insomnia in neurological diseases}},
  journal = {Neurological research and practice},
  year    = {2021},
  doi     = {10.1186/s42466-021-00106-3},
  pmid    = {33691803},
  url     = {https://doi.org/10.1186/s42466-021-00106-3}
}

@article{soheili2021-33953850,
  author  = {Soheili, Masoud and Karimian, Mohammad and Hamidi, Gholamali and Salami, Mahmoud},
  title   = {{Alzheimer's disease treatment: The share of herbal medicines}},
  journal = {Iranian journal of basic medical sciences},
  year    = {2021},
  doi     = {10.22038/ijbms.2020.50536.11512},
  pmid    = {33953850},
  url     = {https://doi.org/10.22038/ijbms.2020.50536.11512}
}

@article{badwal2022-33461372,
  author  = {Badwal, Karun and Kiliaki, Shangwe A and Dugani, Sagar B and Pagali, Sandeep R},
  title   = {{Psychosis Management in Lewy Body Dementia: A Comprehensive Clinical Approach}},
  journal = {Journal of geriatric psychiatry and neurology},
  year    = {2022},
  doi     = {10.1177/0891988720988916},
  pmid    = {33461372},
  url     = {https://doi.org/10.1177/0891988720988916}
}

@article{przybylowska2021-33342413,
  author  = {Przybyłowska, Maja and Dzierzbicka, Krystyna and Kowalski, Szymon and Chmielewska, Klaudia and Inkielewicz-Stepniak, Iwona},
  title   = {{Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors}},
  journal = {Current neuropharmacology},
  year    = {2021},
  doi     = {10.2174/1570159x19666201218103434},
  pmid    = {33342413},
  url     = {https://doi.org/10.2174/1570159x19666201218103434}
}

@article{deng2020-32429787,
  author  = {Deng, X. and Zhao, S. and Liu, X. and Han, L. and Wang, R. and Hao, H. and Jiao, Y. and Han, S. and others},
  title   = {{Polygala tenuifolia : a source for anti-Alzheimer's disease drugs}},
  journal = {Pharmaceutical biology},
  year    = {2020},
  doi     = {10.1080/13880209.2020.1758732},
  pmid    = {32429787},
  url     = {https://doi.org/10.1080/13880209.2020.1758732}
}

@article{yiannopoulou2020-32165850,
  author  = {Yiannopoulou, K. G. and Papageorgiou, S. G.},
  title   = {{Current and Future Treatments in Alzheimer Disease: An Update}},
  journal = {Journal of central nervous system disease},
  year    = {2020},
  doi     = {10.1177/1179573520907397},
  pmid    = {32165850},
  url     = {https://doi.org/10.1177/1179573520907397}
}

@article{kasper2020-32019392,
  author  = {Kasper, Siegfried F. and Bancher, C. and Eckert, Anne and Förstl, Hans and Frölich, Lutz and Hort, Jakub and Korczyn, Amos D. and Kressig, Reto Werner and others},
  title   = {{Management of mild cognitive impairment (MCI): The need for national and international guidelines}},
  journal = {The World Journal of Biological Psychiatry},
  year    = {2020},
  doi     = {10.1080/15622975.2019.1696473},
  pmid    = {32019392},
  url     = {https://doi.org/10.1080/15622975.2019.1696473}
}

@article{tolar2020-31706733,
  author  = {Tolar, M. and Abushakra, S. and Sabbagh, M.},
  title   = {{The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1016/j.jalz.2019.09.075},
  pmid    = {31706733},
  url     = {https://doi.org/10.1016/j.jalz.2019.09.075}
}

@article{joe2019-31810978,
  author  = {Joe, E. and Ringman, J. M.},
  title   = {{Cognitive symptoms of Alzheimer's disease: clinical management and prevention}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2019},
  doi     = {10.1136/bmj.l6217},
  pmid    = {31810978},
  url     = {https://doi.org/10.1136/bmj.l6217}
}

@article{luan2019-31534817,
  author  = {Luan, X. and Tian, X. and Zhang, H. and Huang, R. and Li, N. and Chen, P. and Wang, R.},
  title   = {{Exercise as a prescription for patients with various diseases}},
  journal = {Journal of sport and health science},
  year    = {2019},
  doi     = {10.1016/j.jshs.2019.04.002},
  pmid    = {31534817},
  url     = {https://doi.org/10.1016/j.jshs.2019.04.002}
}

@article{hampel2019-30569080,
  author  = {Hampel, H. and Mesulam, M. M. and Cuello, A. C. and Khachaturian, A. S. and Vergallo, A. and Farlow, M. R. and Snyder, P. J. and Giacobini, E. and others},
  title   = {{Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2019},
  doi     = {10.14283/jpad.2018.43},
  pmid    = {30569080},
  url     = {https://doi.org/10.14283/jpad.2018.43}
}

@article{dossantos2018-30405413,
  author  = {Dos Santos, T. C. and Gomes, T. M. and Pinto, B. A. S. and Camara, A. L. and Paes, A. M. A.},
  title   = {{Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy}},
  journal = {Frontiers in pharmacology},
  year    = {2018},
  doi     = {10.3389/fphar.2018.01192},
  pmid    = {30405413},
  url     = {https://doi.org/10.3389/fphar.2018.01192}
}

@article{hampel2018-29850777,
  author  = {Hampel, H. and Mesulam, M. M. and Cuello, A. C. and Farlow, M. R. and Giacobini, E. and Grossberg, G. T. and Khachaturian, A. S. and Vergallo, A. and others},
  title   = {{The cholinergic system in the pathophysiology and treatment of Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awy132},
  pmid    = {29850777},
  url     = {https://doi.org/10.1093/brain/awy132}
}

@article{duraes2018-29751602,
  author  = {Durães, F. and Pinto, M. and Sousa, E.},
  title   = {{Old Drugs as New Treatments for Neurodegenerative Diseases}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2018},
  doi     = {10.3390/ph11020044},
  pmid    = {29751602},
  url     = {https://doi.org/10.3390/ph11020044}
}

@article{zisapel2018-29318587,
  author  = {Zisapel, N.},
  title   = {{New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation}},
  journal = {British journal of pharmacology},
  year    = {2018},
  doi     = {10.1111/bph.14116},
  pmid    = {29318587},
  url     = {https://doi.org/10.1111/bph.14116}
}

@article{brashear2018-30412493,
  author  = {Brashear, H. R. and Ketter, N. and Bogert, J. and Di, J. and Salloway, S. P. and Sperling, R.},
  title   = {{Clinical Evaluation of Amyloid-Related Imaging Abnormalities in Bapineuzumab Phase III Studies}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-180675},
  pmid    = {30412493},
  url     = {https://doi.org/10.3233/jad-180675}
}

@article{cummings2016-29067309,
  author  = {Cummings, Jeffrey and Morstorf, Travis and Lee, Garam},
  title   = {{Alzheimer's drug-development pipeline: 2016}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2016},
  doi     = {10.1016/j.trci.2016.07.001},
  pmid    = {29067309},
  url     = {https://doi.org/10.1016/j.trci.2016.07.001}
}

@article{tesseur2013-23704554,
  author  = {Tesseur, I. and Lo, A. C. and Roberfroid, A. and Dietvorst, S. and Van Broeck, B. and Borgers, M. and Gijsen, H. and Moechars, D. and others},
  title   = {{Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"}},
  journal = {Science (New York, N.Y.)},
  year    = {2013},
  doi     = {10.1126/science.1233937},
  pmid    = {23704554},
  url     = {https://doi.org/10.1126/science.1233937}
}

@article{lai2012-22233227,
  author  = {Lai, S. W. and Lin, C. H. and Liao, K. F. and Su, L. T. and Sung, F. C. and Lin, C. C.},
  title   = {{Association between polypharmacy and dementia in older people: a population-based case-control study in Taiwan}},
  journal = {Geriatrics \& gerontology international},
  year    = {2012},
  doi     = {10.1111/j.1447-0594.2011.00800.x},
  pmid    = {22233227},
  url     = {https://doi.org/10.1111/j.1447-0594.2011.00800.x}
}

@article{gauthier2009-19896588,
  author  = {Gauthier, Serge and Scheltens, Philip},
  title   = {{Can we do better in developing new drugs for Alzheimer's disease?}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2009},
  doi     = {10.1016/j.jalz.2009.09.002},
  pmid    = {19896588},
  url     = {https://doi.org/10.1016/j.jalz.2009.09.002}
}

@article{lopez2009-19204022,
  author  = {Lopez, O. L. and Becker, J. T. and Wahed, A. S. and Saxton, J. and Sweet, R. A. and Wolk, D. A. and Klunk, W. and Dekosky, S. T.},
  title   = {{Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2009},
  doi     = {10.1136/jnnp.2008.158964},
  pmid    = {19204022},
  url     = {https://doi.org/10.1136/jnnp.2008.158964}
}

@article{pariente2008-18508393,
  author  = {Pariente, Antoine and Helmer, Catherine and Merliere, Yvon and Moore, Nicholas and Fourrier-Réglat, Annie and Dartigues, Jean-Francois},
  title   = {{Prevalence of cholinesterase inhibitors in subjects with dementia in Europe}},
  journal = {Pharmacoepidemiology and drug safety},
  year    = {2008},
  doi     = {10.1002/pds.1613},
  pmid    = {18508393},
  url     = {https://doi.org/10.1002/pds.1613}
}

@article{khachaturian2006-16533956,
  author  = {Khachaturian, A. S. and Zandi, P. P. and Lyketsos, C. G. and Hayden, K. M. and Skoog, I. and Norton, M. C. and Tschanz, J. T. and Mayer, L. S. and others},
  title   = {{Antihypertensive medication use and incident Alzheimer disease: the Cache County Study}},
  journal = {Archives of neurology},
  year    = {2006},
  doi     = {10.1001/archneur.63.5.noc60013},
  pmid    = {16533956},
  url     = {https://doi.org/10.1001/archneur.63.5.noc60013}
}

@article{vandam2005-15654502,
  author  = {Van Dam, Debby and Abramowski, Dorothee and Staufenbiel, Matthias and De Deyn, Peter Paul},
  title   = {{Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model}},
  journal = {Psychopharmacology},
  year    = {2005},
  doi     = {10.1007/s00213-004-2132-z},
  pmid    = {15654502},
  url     = {https://doi.org/10.1007/s00213-004-2132-z}
}

@article{gais2004-14766981,
  author  = {Gais, S. and Born, J.},
  title   = {{Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2004},
  doi     = {10.1073/pnas.0305404101},
  pmid    = {14766981},
  url     = {https://doi.org/10.1073/pnas.0305404101}
}

@article{rabiei2025-32628a51,
  author  = {Rabiei, K. and Petrella, JR. and Lenhart, S. and Liu, C. and Doraiswamy, P. M. and Hao, W.},
  title   = {{Data-Driven Modeling of Amyloid-beta Targeted Antibodies for Alzheimer’s Disease}},
  journal = {NPJ systems biology and applications},
  year    = {2025},
  doi     = {10.21203/rs.3.rs-6316455/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-6316455/v1}
}

@article{boxer2023-37848035,
  author  = {Boxer, A. L. and Sperling, R.},
  title   = {{Accelerating Alzheimer's therapeutic development: The past and future of clinical trials}},
  journal = {Cell},
  year    = {2023},
  doi     = {10.1016/j.cell.2023.09.023},
  pmid    = {37848035},
  url     = {https://doi.org/10.1016/j.cell.2023.09.023}
}

@article{salemme2023-37975226,
  author  = {Salemme, S. and Ancidoni, A. and Locuratolo, N. and Piscopo, P. and Lacorte, E. and Canevelli, M. and Vanacore, N.},
  title   = {{Advances in amyloid-targeting monoclonal antibodies for Alzheimer's disease: clinical and public health issues}},
  journal = {Expert review of neurotherapeutics},
  year    = {2023},
  doi     = {10.1080/14737175.2023.2284305},
  pmid    = {37975226},
  url     = {https://doi.org/10.1080/14737175.2023.2284305}
}

@article{nowell2023-37328112,
  author  = {Nowell, J. and Blunt, E. and Gupta, D. and Edison, P.},
  title   = {{Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2023.101979},
  pmid    = {37328112},
  url     = {https://doi.org/10.1016/j.arr.2023.101979}
}

@article{hoy2023-36856953,
  author  = {Hoy, S. M.},
  title   = {{Lecanemab: First Approval}},
  journal = {Drugs},
  year    = {2023},
  doi     = {10.1007/s40265-023-01851-2},
  pmid    = {36856953},
  url     = {https://doi.org/10.1007/s40265-023-01851-2}
}

@article{yuksel2022-35879846,
  author  = {Yuksel, J. M. and Noviasky, J. and Britton, S.},
  title   = {{Aducanumab for Alzheimer's Disease: Summarized Data From EMERGE, ENGAGE, and PRIME Studies}},
  journal = {The Senior care pharmacist},
  year    = {2022},
  doi     = {10.4140/tcp.n.2022.329},
  pmid    = {35879846},
  url     = {https://doi.org/10.4140/tcp.n.2022.329}
}

@article{behl2022-35231697,
  author  = {Behl, T. and Kaur, I. and Sehgal, A. and Singh, S. and Sharma, N. and Makeen, H. A. and Albratty, M. and Alhazmi, H. A. and others},
  title   = {{"Aducanumab" making a comeback in Alzheimer's disease: An old wine in a new bottle}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2022},
  doi     = {10.1016/j.biopha.2022.112746},
  pmid    = {35231697},
  url     = {https://doi.org/10.1016/j.biopha.2022.112746}
}

@article{dhillon2021-34324167,
  author  = {Dhillon, S.},
  title   = {{Aducanumab: First Approval}},
  journal = {Drugs},
  year    = {2021},
  doi     = {10.1007/s40265-021-01569-z},
  pmid    = {34324167},
  url     = {https://doi.org/10.1007/s40265-021-01569-z}
}

@article{viayna2021-33356266,
  author  = {Viayna, E. and Coquelle, N. and Cieslikiewicz-Bouet, M. and Cisternas, P. and Oliva, C. A. and Sánchez-López, E. and Ettcheto, M. and Bartolini, M. and others},
  title   = {{Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice}},
  journal = {Journal of medicinal chemistry},
  year    = {2021},
  doi     = {10.1021/acs.jmedchem.0c01775},
  pmid    = {33356266},
  url     = {https://doi.org/10.1021/acs.jmedchem.0c01775}
}

@article{marucci2021-33035532,
  author  = {Marucci, G. and Buccioni, M. and Ben, D. D. and Lambertucci, C. and Volpini, R. and Amenta, F.},
  title   = {{Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease}},
  journal = {Neuropharmacology},
  year    = {2021},
  doi     = {10.1016/j.neuropharm.2020.108352},
  pmid    = {33035532},
  url     = {https://doi.org/10.1016/j.neuropharm.2020.108352}
}

@article{reus2016-27133416,
  author  = {Reus, Victor I. and Fochtmann, Laura J. and Eyler, A. Evan and Hilty, Donald M. and Horvitz-Lennon, Marcela V. and Jibson, Michael D. and López, Oscar L. and Mahoney, Jane and others},
  title   = {{The American Psychiatric Association Practice Guideline on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients With Dementia}},
  journal = {American Journal of Psychiatry},
  year    = {2016},
  doi     = {10.1176/appi.ajp.2015.173501},
  pmid    = {27133416},
  url     = {https://doi.org/10.1176/appi.ajp.2015.173501}
}

@article{hughes2016-27199640,
  author  = {Hughes, R. E. and Nikolic, K. and Ramsay, R. R.},
  title   = {{One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug}},
  journal = {Frontiers in neuroscience},
  year    = {2016},
  doi     = {10.3389/fnins.2016.00177},
  pmid    = {27199640},
  url     = {https://doi.org/10.3389/fnins.2016.00177}
}

@article{guzior2015-25386820,
  author  = {Guzior, N. and Wieckowska, A. and Panek, D. and Malawska, B.},
  title   = {{Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease}},
  journal = {Current medicinal chemistry},
  year    = {2015},
  doi     = {10.2174/0929867321666141106122628},
  pmid    = {25386820},
  url     = {https://doi.org/10.2174/0929867321666141106122628}
}

@article{lannfelt2014-25031633,
  author  = {Lannfelt, L. and Möller, C. and Basun, H. and Osswald, G. and Sehlin, D. and Satlin, A. and Logovinsky, V. and Gellerfors, P.},
  title   = {{Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2014},
  doi     = {10.1186/alzrt246},
  pmid    = {25031633},
  url     = {https://doi.org/10.1186/alzrt246}
}

@article{vellas2013-23809364,
  author  = {Vellas, B. and Carrillo, M. C. and Sampaio, C. and Brashear, H. R. and Siemers, E. and Hampel, H. and Schneider, L. S. and Weiner, M. and others},
  title   = {{Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2013},
  doi     = {10.1016/j.jalz.2013.03.007},
  pmid    = {23809364},
  url     = {https://doi.org/10.1016/j.jalz.2013.03.007}
}

@article{parsons2013-23657927,
  author  = {Parsons, C. G. and Danysz, W. and Dekundy, A. and Pulte, I.},
  title   = {{Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease}},
  journal = {Neurotoxicity research},
  year    = {2013},
  doi     = {10.1007/s12640-013-9398-z},
  pmid    = {23657927},
  url     = {https://doi.org/10.1007/s12640-013-9398-z}
}

@article{colovic2013-24179466,
  author  = {Colović, M. B. and Krstić, D. Z. and Lazarević-Pašti, T. D. and Bondžić, A. M. and Vasić, V. M.},
  title   = {{Acetylcholinesterase inhibitors: pharmacology and toxicology}},
  journal = {Current neuropharmacology},
  year    = {2013},
  doi     = {10.2174/1570159x11311030006},
  pmid    = {24179466},
  url     = {https://doi.org/10.2174/1570159x11311030006}
}

@article{fazil2012-22561106,
  author  = {Fazil, M. and Md, S. and Haque, S. and Kumar, M. and Baboota, S. and Sahni, J. K. and Ali, J.},
  title   = {{Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting}},
  journal = {European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year    = {2012},
  doi     = {10.1016/j.ejps.2012.04.013},
  pmid    = {22561106},
  url     = {https://doi.org/10.1016/j.ejps.2012.04.013}
}

@article{mehta2012-22216416,
  author  = {Mehta, M. and Adem, A. and Sabbagh, M.},
  title   = {{New acetylcholinesterase inhibitors for Alzheimer's disease}},
  journal = {International journal of Alzheimer's disease},
  year    = {2012},
  doi     = {10.1155/2012/728983},
  pmid    = {22216416},
  url     = {https://doi.org/10.1155/2012/728983}
}

@article{goldberg2011-21991283,
  author  = {Goldberg, David P},
  title   = {{The heterogeneity of “major depression”}},
  journal = {World Psychiatry},
  year    = {2011},
  doi     = {10.1002/j.2051-5545.2011.tb00061.x},
  pmid    = {21991283},
  url     = {https://doi.org/10.1002/j.2051-5545.2011.tb00061.x}
}

@article{pohanka2011-21731462,
  author  = {Pohanka, M. and Hrabinova, M. and Kuca, K. and Simonato, J. P.},
  title   = {{Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method}},
  journal = {International journal of molecular sciences},
  year    = {2011},
  doi     = {10.3390/ijms12042631},
  pmid    = {21731462},
  url     = {https://doi.org/10.3390/ijms12042631}
}

@article{casey2010-20498822,
  author  = {Casey, David and Antimisiaris, Demetra E. and O’Brien, James G.},
  title   = {{Drugs for Alzheimer's disease: are they effective?}},
  journal = {PubMed Central},
  year    = {2010},
  pmid    = {20498822}
}

@article{valiyeva2008-18725616,
  author  = {Valiyeva, E. and Herrmann, N. and Rochon, P. A. and Gill, S. S. and Anderson, G. M.},
  title   = {{Effect of regulatory warnings on antipsychotic prescription rates among elderly patients with dementia: a population-based time-series analysis}},
  journal = {CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne},
  year    = {2008},
  doi     = {10.1503/cmaj.071540},
  pmid    = {18725616},
  url     = {https://doi.org/10.1503/cmaj.071540}
}

@article{atri2008-18580597,
  author  = {Atri, Alireza and Shaughnessy, Lynn W. and Locascio, Joseph J. and Growdon, John H.},
  title   = {{Long-term Course and Effectiveness of Combination Therapy in Alzheimer Disease}},
  journal = {Alzheimer Disease \& Associated Disorders},
  year    = {2008},
  doi     = {10.1097/wad.0b013e31816653bc},
  pmid    = {18580597},
  url     = {https://doi.org/10.1097/wad.0b013e31816653bc}
}

@article{qaseem2008-18316755,
  author  = {Qaseem, A. and Snow, V. and Cross, J. T. and Forciea, M. A. and Hopkins, R. and Shekelle, P. and Adelman, A. and Mehr, D. and others},
  title   = {{Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians}},
  journal = {Annals of internal medicine},
  year    = {2008},
  doi     = {10.7326/0003-4819-148-5-200803040-00008},
  pmid    = {18316755},
  url     = {https://doi.org/10.7326/0003-4819-148-5-200803040-00008}
}

@article{baum2008-18204357,
  author  = {Baum, Larry and Lam, Christopher Wai Kei and Cheung, Stanley K. K. and Kwok, Timothy C. Y. and Lui, Victor Wing-Cheong and Tsoh, Joshua and LINDA C. W., L. A. M. and Leung, Vivian and others},
  title   = {{Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease}},
  journal = {Journal of Clinical Psychopharmacology},
  year    = {2008},
  doi     = {10.1097/jcp.0b013e318160862c},
  pmid    = {18204357},
  url     = {https://doi.org/10.1097/jcp.0b013e318160862c}
}

@article{calabresi2006-17052664,
  author  = {Calabresi, P. and Picconi, B. and Parnetti, L. and Di Filippo, M.},
  title   = {{A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance}},
  journal = {The Lancet. Neurology},
  year    = {2006},
  doi     = {10.1016/s1474-4422(06)70600-7},
  pmid    = {17052664},
  url     = {https://doi.org/10.1016/s1474-4422(06)70600-7}
}

@article{cummings2006-16832078,
  author  = {Cummings, Jeffrey L. and Schneider, Eugene and Tariot, Pierre N. and Graham, Stephen M.},
  title   = {{Behavioral effects of memantine in Alzheimer disease patients receiving donepezil treatment}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000223333.42368.f1},
  pmid    = {16832078},
  url     = {https://doi.org/10.1212/01.wnl.0000223333.42368.f1}
}

@article{miyasaki2006-16606910,
  author  = {Miyasaki, J. M. and Shannon, K. and Voon, V. and Ravina, B. and Kleiner-Fisman, G. and Anderson, K. and Shulman, L. M. and Gronseth, G. and others},
  title   = {{Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000215428.46057.3d},
  pmid    = {16606910},
  url     = {https://doi.org/10.1212/01.wnl.0000215428.46057.3d}
}

@article{schupbach2005-16291886,
  author  = {Schüpbach, W. M. and Chastan, N. and Welter, M. L. and Houeto, J. L. and Mesnage, V. and Bonnet, A. M. and Czernecki, V. and Maltête, D. and others},
  title   = {{Stimulation of the subthalamic nucleus in Parkinson's disease: a 5 year follow up}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2005},
  doi     = {10.1136/jnnp.2005.063206},
  pmid    = {16291886},
  url     = {https://doi.org/10.1136/jnnp.2005.063206}
}

@article{javitt2004-15278097,
  author  = {Javitt, D. C.},
  title   = {{Glutamate as a therapeutic target in psychiatric disorders}},
  journal = {Molecular psychiatry},
  year    = {2004},
  doi     = {10.1038/sj.mp.4001551},
  pmid    = {15278097},
  url     = {https://doi.org/10.1038/sj.mp.4001551}
}

@article{scarpini2003-12941576,
  author  = {Scarpini, E. and Scheltens, P. and Feldman, H.},
  title   = {{Treatment of Alzheimer's disease: current status and new perspectives}},
  journal = {The Lancet. Neurology},
  year    = {2003},
  doi     = {10.1016/s1474-4422(03)00502-7},
  pmid    = {12941576},
  url     = {https://doi.org/10.1016/s1474-4422(03)00502-7}
}

@article{citron2002-12403985,
  author  = {Citron, M.},
  title   = {{Alzheimer's disease: treatments in discovery and development}},
  journal = {Nature neuroscience},
  year    = {2002},
  doi     = {10.1038/nn940},
  pmid    = {12403985},
  url     = {https://doi.org/10.1038/nn940}
}

@article{sugimoto2002-12083745,
  author  = {Sugimoto, Hachiro and Ogura, Hiroo and Arai, Yasuo and Iimura, Youichi and Yamanishi, Yoshiharu},
  title   = {{Research and Development of Donepezil Hydrochloride, a New Type of Acetylcholinesterase Inhibitor}},
  journal = {The Japanese Journal of Pharmacology},
  year    = {2002},
  doi     = {10.1254/jjp.89.7},
  pmid    = {12083745},
  url     = {https://doi.org/10.1254/jjp.89.7}
}

@article{perry1999-10411211,
  author  = {Perry, Elaine King and Pickering, Anne T. and Wang, Wei Wei and Houghton, Peter J and Perry, Nicolette S L},
  title   = {{Medicinal Plants and Alzheimer's Disease: from Ethnobotany to Phytotherapy}},
  journal = {Journal of Pharmacy and Pharmacology},
  year    = {1999},
  doi     = {10.1211/0022357991772808},
  pmid    = {10411211},
  url     = {https://doi.org/10.1211/0022357991772808}
}

@article{shea1998-9785144,
  author  = {Shea, Catherine and MacKnight, Chris and Rockwood, Kenneth J.},
  title   = {{Donepezil for Treatment of Dementia With Lewy Bodies: A Case Series of Nine Patients}},
  journal = {International Psychogeriatrics},
  year    = {1998},
  doi     = {10.1017/s1041610298005341},
  pmid    = {9785144},
  url     = {https://doi.org/10.1017/s1041610298005341}
}

@article{parsons1995-8570022,
  author  = {Parsons, C. G. and Quack, G. and Bresink, I. and Baran, L. and Przegalinski, E. and Kostowski, W. and Krzascik, P. and Hartmann, S. and others},
  title   = {{Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo}},
  journal = {Neuropharmacology},
  year    = {1995},
  doi     = {10.1016/0028-3908(95)00092-k},
  pmid    = {8570022},
  url     = {https://doi.org/10.1016/0028-3908(95)00092-k}
}

@article{reisberg1987-3553166,
  author  = {Reisberg, ‌Barry and Borenstein, Jeffrey and Salob, Stacy P. and Ferris, Steven H. and Franssen, E. and Georgotas, Anastasios},
  title   = {{Behavioral symptoms in Alzheimer's disease: phenomenology and treatment}},
  journal = {PubMed},
  year    = {1987},
  pmid    = {3553166}
}

@article{perry1978-719462,
  author  = {Perry, E. K. and Tomlinson, B. E. and Blessed, G. and Bergmann, K. and Gibson, P. H. and Perry, R. H.},
  title   = {{Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia}},
  journal = {British medical journal},
  year    = {1978},
  doi     = {10.1136/bmj.2.6150.1457},
  pmid    = {719462},
  url     = {https://doi.org/10.1136/bmj.2.6150.1457}
}

@article{perry1978-703927,
  author  = {Perry, Elaine King and Perry, Robert H. and Blessed, Garry and Tomlinson, B. E.},
  title   = {{CHANGES IN BRAIN CHOLINESTERASES IN SENILE DEMENTIA OF ALZHEIMER TYPE}},
  journal = {Neuropathology and Applied Neurobiology},
  year    = {1978},
  doi     = {10.1111/j.1365-2990.1978.tb00545.x},
  pmid    = {703927},
  url     = {https://doi.org/10.1111/j.1365-2990.1978.tb00545.x}
}

@article{gettman2022-c153db12,
  author  = {Gettman, Lana},
  title   = {{New Drug Update: Dostarlimab, Loncastuximab Tesirine, and Aducanumab}},
  journal = {The Senior Care Pharmacist},
  year    = {2022},
  doi     = {10.4140/tcp.n.2022.9},
  url     = {https://doi.org/10.4140/tcp.n.2022.9}
}

@article{chertkow2021-b7d8f16f,
  author  = {Chertkow, Howard and Rockwood, Kenneth and Hogan, David B. and Phillips, Natalie and Montero-Odasso, Manuel and Amanullah, Shabbir and Black, Sandra and Bocti, Christian and others},
  title   = {{Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab}},
  journal = {Canadian Geriatrics Journal},
  year    = {2021},
  doi     = {10.5770/cgj.24.570},
  url     = {https://doi.org/10.5770/cgj.24.570}
}

@article{gunawardena2021-8f1e1182,
  author  = {Gunawardena, Illangage P. C. and Retinasamy, Thaarvena and Shaikh, Mohd. Farooq},
  title   = {{Is Aducanumab for LMICs? Promises and Challenges}},
  journal = {Brain Sciences},
  year    = {2021},
  doi     = {10.3390/brainsci11111547},
  url     = {https://doi.org/10.3390/brainsci11111547}
}

@article{muralidharan2021-098ca6fa,
  author  = {Muralidharan, Kumar Kandadi and Tong, Xiao and Kowalski, Kenneth G. and Rajagovindan, Raj and Lin, Lin and Haberlain, Samantha Budd and Nestorov, Ivan},
  title   = {{Population pharmacokinetics and standard uptake value ratio of aducanumab, an amyloid plaque–removing agent, in patients with Alzheimer’s disease}},
  journal = {CPT: Pharmacometrics \& Systems Pharmacology},
  year    = {2021},
  doi     = {10.1002/psp4.12728},
  url     = {https://doi.org/10.1002/psp4.12728}
}

@article{mukhopadhyay2021-4e65c051,
  author  = {Mukhopadhyay, Sanchari and Banerjee, Debanjan},
  title   = {{A Primer on the Evolution of Aducanumab: The First Antibody Approved for Treatment of Alzheimer’s Disease}},
  journal = {Journal of Alzheimer's Disease},
  year    = {2021},
  doi     = {10.3233/jad-215065},
  url     = {https://doi.org/10.3233/jad-215065}
}

@article{sanchezmontoya2021-27930c38,
  author  = {Sánchez-Montoya, Eliana and Andresen, Max and Corrales, Raúl and Gallardo, Jorge and Noriega, Viviana and Weinstein-Oppenheimer, Caroline R.},
  title   = {{caso de aducanumab ¿Más esperanza que ciencia?}},
  journal = {ARS MEDICA Revista de Ciencias Médicas},
  year    = {2021},
  doi     = {10.11565/arsmed.v46i3.1826},
  url     = {https://doi.org/10.11565/arsmed.v46i3.1826}
}

@article{lalli2021-f2e71f9d,
  author  = {Lalli, Giovanna and Schott, Jonathan M and Hardy, John and De Strooper, Bart},
  title   = {{Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?}},
  journal = {EMBO Molecular Medicine},
  year    = {2021},
  doi     = {10.15252/emmm.202114781},
  url     = {https://doi.org/10.15252/emmm.202114781}
}

@article{thomas2021-6ea281e6,
  author  = {Thomas, Emily and Wasunna‐Smith, Brenda and Kuruvilla, Tarun},
  title   = {{Aducanumab and disease modifying treatments for Alzheimer's disease}},
  journal = {Progress in Neurology and Psychiatry},
  year    = {2021},
  doi     = {10.1002/pnp.711},
  url     = {https://doi.org/10.1002/pnp.711}
}

@article{retinasamy2021-3dd6d026,
  author  = {Retinasamy, Thaarvena and Shaikh, Mohd. Farooq},
  title   = {{Aducanumab for Alzheimer's disease: An update}},
  journal = {Neuroscience Research Notes},
  year    = {2021},
  doi     = {10.31117/neuroscirn.v4i2.81},
  url     = {https://doi.org/10.31117/neuroscirn.v4i2.81}
}

@article{study2021-38d83515,
  title   = {{Donanemab leads to less decline in early Alzheimer's disease}},
  journal = {The Brown University Psychopharmacology Update},
  year    = {2021},
  doi     = {10.1002/pu.30739},
  url     = {https://doi.org/10.1002/pu.30739}
}

@article{geerts2021-80f66de5,
  author  = {Geerts, Hugo and van der Graaf, Piet},
  title   = {{Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer’s Disease}},
  journal = {Journal of Alzheimer's Disease Reports},
  year    = {2021},
  doi     = {10.3233/adr-210039},
  url     = {https://doi.org/10.3233/adr-210039}
}

@article{takao2020-33293469,
  author  = {Takao, Masaki},
  title   = {{[Dementia of the Oldest-Old]}},
  journal = {Brain and nerve = Shinkei kenkyu no shinpo},
  year    = {2020},
  doi     = {10.11477/mf.1416201692},
  pmid    = {33293469},
  url     = {https://doi.org/10.11477/mf.1416201692}
}

@article{earl2020-32890017,
  author  = {Earl, David C and Van Tyle, Kendall M},
  title   = {{New pharmacologic agents for insomnia and hypersomnia}},
  journal = {Current opinion in pulmonary medicine},
  year    = {2020},
  doi     = {10.1097/mcp.0000000000000722},
  pmid    = {32890017},
  url     = {https://doi.org/10.1097/mcp.0000000000000722}
}

@article{gedawy2020-32967584,
  author  = {Gedawy, Ahmed and Al-Salami, Hani and Dass, Crispin R},
  title   = {{Role of metformin in various pathologies: state-of-the-art microcapsules for improving its pharmacokinetics}},
  journal = {Therapeutic delivery},
  year    = {2020},
  doi     = {10.4155/tde-2020-0102},
  pmid    = {32967584},
  url     = {https://doi.org/10.4155/tde-2020-0102}
}

@article{martins2020-32933034,
  author  = {Martins, Márcia and Silva, Renata and Pinto, Madalena M M and Sousa, Emília},
  title   = {{Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer's Disease}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2020},
  doi     = {10.3390/ph13090242},
  pmid    = {32933034},
  url     = {https://doi.org/10.3390/ph13090242}
}

@article{bauzon2020-32807237,
  author  = {Bauzon, Justin and Lee, Garam and Cummings, Jeffrey},
  title   = {{Repurposed agents in the Alzheimer's disease drug development pipeline}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00662-x},
  pmid    = {32807237},
  url     = {https://doi.org/10.1186/s13195-020-00662-x}
}

@article{cacabelos2020-32520597,
  author  = {Cacabelos, Ramón},
  title   = {{Pharmacogenetic considerations when prescribing cholinesterase inhibitors for the treatment of Alzheimer's disease}},
  journal = {Expert opinion on drug metabolism \& toxicology},
  year    = {2020},
  doi     = {10.1080/17425255.2020.1779700},
  pmid    = {32520597},
  url     = {https://doi.org/10.1080/17425255.2020.1779700}
}

@article{rybakowski2020-33169645,
  author  = {Rybakowski, Janusz K},
  title   = {{Lithium - past, present, future}},
  journal = {International journal of psychiatry in clinical practice},
  year    = {2020},
  doi     = {10.1080/13651501.2020.1775855},
  pmid    = {33169645},
  url     = {https://doi.org/10.1080/13651501.2020.1775855}
}

@article{dubois2020-32322104,
  author  = {Dubois, B and Bombois, S and Villain, N and Teichmann, M and Epelbaum, S and Migliaccio, R and Genthon, R and Verrat, B and others},
  title   = {{[Toward a preventive management Alzheimer's disease]}},
  journal = {Bulletin de l'Academie nationale de medecine},
  year    = {2020},
  doi     = {10.1016/j.banm.2020.04.012},
  pmid    = {32322104},
  url     = {https://doi.org/10.1016/j.banm.2020.04.012}
}

@article{avidan2020-32316081,
  author  = {Avidan, Alon and Burke, Anna},
  title   = {{Identifying and Treating Insomnia in Patients Living With Alzheimer's Disease}},
  journal = {The Journal of clinical psychiatry},
  year    = {2020},
  doi     = {10.4088/jcp.me19014wc1c},
  pmid    = {32316081},
  url     = {https://doi.org/10.4088/jcp.me19014wc1c}
}

@article{scott2020-32096020,
  author  = {Scott, Lesley J},
  title   = {{Lemborexant: First Approval}},
  journal = {Drugs},
  year    = {2020},
  doi     = {10.1007/s40265-020-01276-1},
  pmid    = {32096020},
  url     = {https://doi.org/10.1007/s40265-020-01276-1}
}

@article{dembitsky2020-32037088,
  author  = {Dembitsky, Valery M and Dzhemileva, Lilya and Gloriozova, Tatyana and D'yakonov, Vladimir},
  title   = {{Natural and synthetic drugs used for the treatment of the dementia}},
  journal = {Biochemical and biophysical research communications},
  year    = {2020},
  doi     = {10.1016/j.bbrc.2020.01.123},
  pmid    = {32037088},
  url     = {https://doi.org/10.1016/j.bbrc.2020.01.123}
}

@article{ferinistrambi2020-32025925,
  author  = {Ferini-Strambi, Luigi and Galbiati, Andrea and Casoni, Francesca and Salsone, Maria},
  title   = {{Therapy for Insomnia and Circadian Rhythm Disorder in Alzheimer Disease}},
  journal = {Current treatment options in neurology},
  year    = {2020},
  doi     = {10.1007/s11940-020-0612-z},
  pmid    = {32025925},
  url     = {https://doi.org/10.1007/s11940-020-0612-z}
}

@article{sharma2020-31773661,
  author  = {Sharma, Piyoosh and Tripathi, Manish Kumar and Shrivastava, Sushant Kumar},
  title   = {{Cholinesterase as a Target for Drug Development in Alzheimer's Disease}},
  journal = {Methods in molecular biology (Clifton, N.J.)},
  year    = {2020},
  doi     = {10.1007/978-1-0716-0163-1_18},
  pmid    = {31773661},
  url     = {https://doi.org/10.1007/978-1-0716-0163-1_18}
}

@article{siafaka2020-32552655,
  author  = {Siafaka, Panoraia I and Bülbül, Ece Ö and Mutlu, Gökce and Okur, Mehmet E and Karantas, Ioannis D and Okur, Neslihan Ü},
  title   = {{Transdermal Drug Delivery Systems and their Potential in Alzheimer's Disease Management}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2020},
  doi     = {10.2174/1871527319666200618150046},
  pmid    = {32552655},
  url     = {https://doi.org/10.2174/1871527319666200618150046}
}

@article{ihara2020-32144994,
  author  = {Ihara, Masafumi and Saito, Satoshi},
  title   = {{Drug Repositioning for Alzheimer's Disease: Finding Hidden Clues in Old Drugs}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200049},
  pmid    = {32144994},
  url     = {https://doi.org/10.3233/jad-200049}
}

@article{malik2019-32025385,
  author  = {Malik, Bilal Haider and Hamid, Pousette and Khan, Safeera and Gupta, Deepti and Islam, Muhammad},
  title   = {{Correlation Between Donepezil and QTc Prolongation and Torsades de Pointes: A Very Rare Phenomenon}},
  journal = {Cureus},
  year    = {2019},
  doi     = {10.7759/cureus.6451},
  pmid    = {32025385},
  url     = {https://doi.org/10.7759/cureus.6451}
}

@article{ralls2019-31589188,
  author  = {Ralls, Frank and Cutchen, Lisa},
  title   = {{A contemporary review of obstructive sleep apnea}},
  journal = {Current opinion in pulmonary medicine},
  year    = {2019},
  doi     = {10.1097/mcp.0000000000000623},
  pmid    = {31589188},
  url     = {https://doi.org/10.1097/mcp.0000000000000623}
}

@article{paranjpe2019-31326236,
  author  = {Paranjpe, Manish D and Taubes, Alice and Sirota, Marina},
  title   = {{Insights into Computational Drug Repurposing for Neurodegenerative Disease}},
  journal = {Trends in pharmacological sciences},
  year    = {2019},
  doi     = {10.1016/j.tips.2019.06.003},
  pmid    = {31326236},
  url     = {https://doi.org/10.1016/j.tips.2019.06.003}
}

@article{altuntas2019-32377065,
  author  = {Altuntaş, Yüksel},
  title   = {{Approach Toward Diabetes Treatment in the Elderly}},
  journal = {Sisli Etfal Hastanesi tip bulteni},
  year    = {2019},
  doi     = {10.14744/semb.2019.00868},
  pmid    = {32377065},
  url     = {https://doi.org/10.14744/semb.2019.00868}
}

@article{kabir2019-31593530,
  author  = {Kabir, Md Tanvir and Uddin, Md Sahab and Begum, Mst Marium and Thangapandiyan, Shanmugam and Rahman, Md Sohanur and Aleya, Lotfi and Mathew, Bijo and Ahmed, Muniruddin and others},
  title   = {{Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning}},
  journal = {Current pharmaceutical design},
  year    = {2019},
  doi     = {10.2174/1381612825666191008103141},
  pmid    = {31593530},
  url     = {https://doi.org/10.2174/1381612825666191008103141}
}

@article{wen2019-31724518,
  author  = {Wen, Jinhua and Sawmiller, Darrell and Wheeldon, Brendan and Tan, Jun},
  title   = {{A Review for Lithium: Pharmacokinetics, Drug Design, and Toxicity}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2019},
  doi     = {10.2174/1871527318666191114095249},
  pmid    = {31724518},
  url     = {https://doi.org/10.2174/1871527318666191114095249}
}

@article{hassan2019-30551512,
  author  = {Hassan, Mubashir and Raza, Hussain and Abbasi, Muhammad Athar and Moustafa, Ahmed A and Seo, Sung-Yum},
  title   = {{The exploration of novel Alzheimer's therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2019},
  doi     = {10.1016/j.biopha.2018.11.115},
  pmid    = {30551512},
  url     = {https://doi.org/10.1016/j.biopha.2018.11.115}
}

@article{heard2018-30425653,
  author  = {Heard, Daniel S and Tuttle, Camilla S L and Lautenschlager, Nicola T and Maier, Andrea B},
  title   = {{Repurposing Proteostasis-Modifying Drugs to Prevent or Treat Age-Related Dementia: A Systematic Review}},
  journal = {Frontiers in physiology},
  year    = {2018},
  doi     = {10.3389/fphys.2018.01520},
  pmid    = {30425653},
  url     = {https://doi.org/10.3389/fphys.2018.01520}
}

@article{zhang2018-30349215,
  author  = {Zhang, Nan and Gordon, Marc L},
  title   = {{Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients}},
  journal = {Clinical interventions in aging},
  year    = {2018},
  doi     = {10.2147/cia.s159920},
  pmid    = {30349215},
  url     = {https://doi.org/10.2147/cia.s159920}
}

@article{agatonovickustrin2018-29990843,
  author  = {Agatonovic-Kustrin, Snezana and Kettle, Christine and Morton, David W},
  title   = {{A molecular approach in drug development for Alzheimer's disease}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2018},
  doi     = {10.1016/j.biopha.2018.06.147},
  pmid    = {29990843},
  url     = {https://doi.org/10.1016/j.biopha.2018.06.147}
}

@article{dafsari2018-29689582,
  author  = {Dafsari, Forugh S and Jessen, Frank},
  title   = {{[Late life depression - Diagnosis, pathophysiology and therapeutic strategies]}},
  journal = {Fortschritte der Neurologie-Psychiatrie},
  year    = {2018},
  doi     = {10.1055/s-0043-119799},
  pmid    = {29689582},
  url     = {https://doi.org/10.1055/s-0043-119799}
}

@article{beyer2018-29627920,
  author  = {Beyer, John L and Johnson, Kim G},
  title   = {{Advances in Pharmacotherapy of Late-Life Depression}},
  journal = {Current psychiatry reports},
  year    = {2018},
  doi     = {10.1007/s11920-018-0899-6},
  pmid    = {29627920},
  url     = {https://doi.org/10.1007/s11920-018-0899-6}
}

@article{darrigo2018-31105226,
  author  = {D'Arrigo, Joseph S},
  title   = {{Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood⁻Brain Barrier}},
  journal = {Biomimetics (Basel, Switzerland)},
  year    = {2018},
  doi     = {10.3390/biomimetics3010004},
  pmid    = {31105226},
  url     = {https://doi.org/10.3390/biomimetics3010004}
}

@article{patel2018-29661329,
  author  = {Patel, Rohan and McKinnon, Brian J},
  title   = {{Hearing Loss in the Elderly}},
  journal = {Clinics in geriatric medicine},
  year    = {2018},
  doi     = {10.1016/j.cger.2018.01.001},
  pmid    = {29661329},
  url     = {https://doi.org/10.1016/j.cger.2018.01.001}
}

@article{bailey2018-29409574,
  author  = {Bailey, Trista Askins and Panjwani, Sehrish},
  title   = {{Atypical Antipsychotics in Late-Life and Treatment-Resistant Depression}},
  journal = {The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists},
  year    = {2018},
  doi     = {10.4140/tcp.n.2018.83},
  pmid    = {29409574},
  url     = {https://doi.org/10.4140/tcp.n.2018.83}
}

@article{krolaksalmon2018-30282371,
  author  = {Krolak-Salmon, Pierre and Dubois, Bruno and Sellal, François and Delabrousse-Mayoux, Jean-Philippe and Vandel, Pierre and Amieva, Hélène and Jeandel, Claude and Andrieu, Sandrine and others},
  title   = {{France Will No More Reimburse Available Symptomatic Drugs Against Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-180843},
  pmid    = {30282371},
  url     = {https://doi.org/10.3233/jad-180843}
}

@article{panza2018-29037101,
  author  = {Panza, Francesco and Seripa, Davide and Lozupone, Madia and Solfrizzi, Vincenzo and Imbimbo, Bruno P and Barulli, Maria Rosaria and Tortelli, Rosanna and Capozzo, Rosa and others},
  title   = {{The potential of solanezumab and gantenerumab to prevent Alzheimer's disease in people with inherited mutations that cause its early onset}},
  journal = {Expert opinion on biological therapy},
  year    = {2018},
  doi     = {10.1080/14712598.2018.1389885},
  pmid    = {29037101},
  url     = {https://doi.org/10.1080/14712598.2018.1389885}
}

@article{tariq2018-28734089,
  author  = {Tariq, Sana and Barber, Philip A},
  title   = {{Dementia risk and prevention by targeting modifiable vascular risk factors}},
  journal = {Journal of neurochemistry},
  year    = {2018},
  doi     = {10.1111/jnc.14132},
  pmid    = {28734089},
  url     = {https://doi.org/10.1111/jnc.14132}
}

@article{farooq2017-28786085,
  author  = {Farooq, Muhammad U and Min, Jiangyong and Goshgarian, Christopher and Gorelick, Philip B},
  title   = {{Pharmacotherapy for Vascular Cognitive Impairment}},
  journal = {CNS drugs},
  year    = {2017},
  doi     = {10.1007/s40263-017-0459-3},
  pmid    = {28786085},
  url     = {https://doi.org/10.1007/s40263-017-0459-3}
}

@article{campbell2017-28800055,
  author  = {Campbell, Jared M and Stephenson, Matthew D and de Courten, Barbora and Chapman, Ian and Bellman, Susan M and Aromataris, Edoardo},
  title   = {{Metformin and Alzheimer's disease, dementia and cognitive impairment: a systematic review protocol}},
  journal = {JBI database of systematic reviews and implementation reports},
  year    = {2017},
  doi     = {10.11124/jbisrir-2017-003380},
  pmid    = {28800055},
  url     = {https://doi.org/10.11124/jbisrir-2017-003380}
}

@article{mohammad2017-28678552,
  author  = {Mohammad, Dana and Chan, Parco and Bradley, Janelle and Lanctôt, Krista and Herrmann, Nathan},
  title   = {{Acetylcholinesterase inhibitors for treating dementia symptoms - a safety evaluation}},
  journal = {Expert opinion on drug safety},
  year    = {2017},
  doi     = {10.1080/14740338.2017.1351540},
  pmid    = {28678552},
  url     = {https://doi.org/10.1080/14740338.2017.1351540}
}

@article{markowiczpiasecka2017-28770024,
  author  = {Markowicz-Piasecka, Magdalena and Sikora, Joanna and Mateusiak, Łukasz and Mikiciuk-Olasik, Elżbieta and Huttunen, Kristiina M},
  title   = {{Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2017},
  doi     = {10.1155/2017/7303096},
  pmid    = {28770024},
  url     = {https://doi.org/10.1155/2017/7303096}
}

@article{ali2017-28711758,
  author  = {Ali, M Rejwan and Sadoqi, Mostafa and Møller, Simon G and Boutajangout, Allal and Mezei, Mihaly},
  title   = {{Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies}},
  journal = {Journal of molecular graphics \& modelling},
  year    = {2017},
  doi     = {10.1016/j.jmgm.2017.06.027},
  pmid    = {28711758},
  url     = {https://doi.org/10.1016/j.jmgm.2017.06.027}
}

@article{study2017-28560923,
  title   = {{Anti-tau vaccine is successful in clinical trial for people with Alzheimer's disease}},
  journal = {Nursing older people},
  year    = {2017},
  doi     = {10.7748/nop.29.5.11.s12},
  pmid    = {28560923},
  url     = {https://doi.org/10.7748/nop.29.5.11.s12}
}

@article{naguy2018-28558251,
  author  = {Naguy, Ahmed},
  title   = {{Omega-3 Use in Psychiatry: Evidence-Based or Elegance-Based?}},
  journal = {Journal of dietary supplements},
  year    = {2018},
  doi     = {10.1080/19390211.2017.1326432},
  pmid    = {28558251},
  url     = {https://doi.org/10.1080/19390211.2017.1326432}
}

@article{saeed2017-28324298,
  author  = {Saeed, Yumna and Abbott, Sabra M},
  title   = {{Circadian Disruption Associated with Alzheimer's Disease}},
  journal = {Current neurology and neuroscience reports},
  year    = {2017},
  doi     = {10.1007/s11910-017-0745-y},
  pmid    = {28324298},
  url     = {https://doi.org/10.1007/s11910-017-0745-y}
}

@article{caraci2017-28260511,
  author  = {Caraci, Filippo and Sultana, Janet and Drago, Filippo and Spina, Edoardo},
  title   = {{Clinically Relevant Drug Interactions with Anti-Alzheimer's Drugs}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2017},
  doi     = {10.2174/1871527316666170303144817},
  pmid    = {28260511},
  url     = {https://doi.org/10.2174/1871527316666170303144817}
}

@article{galimberti2017-27885860,
  author  = {Galimberti, Daniela and Scarpini, Elio},
  title   = {{Pioglitazone for the treatment of Alzheimer's disease}},
  journal = {Expert opinion on investigational drugs},
  year    = {2017},
  doi     = {10.1080/13543784.2017.1265504},
  pmid    = {27885860},
  url     = {https://doi.org/10.1080/13543784.2017.1265504}
}

@article{maschke2017-27285978,
  author  = {Maschke, Karen J and Gusmano, Michael K},
  title   = {{Medicare and Amyloid PET Imaging: The Battle Over Evidence}},
  journal = {Journal of aging \& social policy},
  year    = {2017},
  doi     = {10.1080/08959420.2016.1198970},
  pmid    = {27285978},
  url     = {https://doi.org/10.1080/08959420.2016.1198970}
}

@article{lewitt2020-33349582,
  author  = {LeWitt, P. A. and Chaudhuri, K. R.},
  title   = {{Unmet needs in Parkinson disease: Motor and non-motor}},
  journal = {Parkinsonism \& related disorders},
  year    = {2020},
  doi     = {10.1016/j.parkreldis.2020.09.024},
  pmid    = {33349582},
  url     = {https://doi.org/10.1016/j.parkreldis.2020.09.024}
}

@article{mullane2020-32247851,
  author  = {Mullane, K. and Williams, M.},
  title   = {{Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?}},
  journal = {Biochemical pharmacology},
  year    = {2020},
  doi     = {10.1016/j.bcp.2020.113945},
  pmid    = {32247851},
  url     = {https://doi.org/10.1016/j.bcp.2020.113945}
}

@article{aisen2020-32463066,
  author  = {Aisen, P. S. and Cummings, J. and Doody, R. and Kramer, L. and Salloway, S. and Selkoe, D. J. and Sims, J. and Sperling, R. A. and others},
  title   = {{The Future of Anti-Amyloid Trials}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2020},
  doi     = {10.14283/jpad.2020.24},
  pmid    = {32463066},
  url     = {https://doi.org/10.14283/jpad.2020.24}
}

@article{atri2019-30925615,
  author  = {Atri, A.},
  title   = {{Current and Future Treatments in Alzheimer's Disease}},
  journal = {Seminars in neurology},
  year    = {2019},
  doi     = {10.1055/s-0039-1678581},
  pmid    = {30925615},
  url     = {https://doi.org/10.1055/s-0039-1678581}
}

@article{fraguassanchez2018-30374797,
  author  = {Fraguas-Sánchez, A. I. and Torres-Suárez, A. I.},
  title   = {{Medical Use of Cannabinoids}},
  journal = {Drugs},
  year    = {2018},
  doi     = {10.1007/s40265-018-0996-1},
  pmid    = {30374797},
  url     = {https://doi.org/10.1007/s40265-018-0996-1}
}

@article{lao2019-29732929,
  author  = {Lao, K. and Ji, N. and Zhang, X. and Qiao, W. and Tang, Z. and Gou, X.},
  title   = {{Drug development for Alzheimer's disease: review}},
  journal = {Journal of drug targeting},
  year    = {2019},
  doi     = {10.1080/1061186x.2018.1474361},
  pmid    = {29732929},
  url     = {https://doi.org/10.1080/1061186x.2018.1474361}
}

@article{agrawal2018-29772289,
  author  = {Agrawal, M. and Saraf, S. and Antimisiaris, S. G. and Chougule, M. B. and Shoyele, S. A. and Alexander, A.},
  title   = {{Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs}},
  journal = {Journal of controlled release : official journal of the Controlled Release Society},
  year    = {2018},
  doi     = {10.1016/j.jconrel.2018.05.011},
  pmid    = {29772289},
  url     = {https://doi.org/10.1016/j.jconrel.2018.05.011}
}

@article{yulug2018-29315976,
  author  = {Yulug, B. and Hanoglu, L. and Ozansoy, M. and Isık, D. and Kilic, U. and Kilic, E. and Schabitz, W. R.},
  title   = {{Therapeutic role of rifampicin in Alzheimer's disease}},
  journal = {Psychiatry and clinical neurosciences},
  year    = {2018},
  doi     = {10.1111/pcn.12637},
  pmid    = {29315976},
  url     = {https://doi.org/10.1111/pcn.12637}
}

@article{hauser2017-29075003,
  author  = {Hauser, A. S. and Attwood, M. M. and Rask-Andersen, M. and Schiöth, H. B. and Gloriam, D. E.},
  title   = {{Trends in GPCR drug discovery: new agents, targets and indications}},
  journal = {Nature reviews. Drug discovery},
  year    = {2017},
  doi     = {10.1038/nrd.2017.178},
  pmid    = {29075003},
  url     = {https://doi.org/10.1038/nrd.2017.178}
}

@article{prati2018-28749667,
  author  = {Prati, F. and Bottegoni, G. and Bolognesi, M. L. and Cavalli, A.},
  title   = {{BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease}},
  journal = {Journal of medicinal chemistry},
  year    = {2018},
  doi     = {10.1021/acs.jmedchem.7b00393},
  pmid    = {28749667},
  url     = {https://doi.org/10.1021/acs.jmedchem.7b00393}
}

@article{dey2017-28043897,
  author  = {Dey, A. and Bhattacharya, R. and Mukherjee, A. and Pandey, D. K.},
  title   = {{Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions}},
  journal = {Biotechnology advances},
  year    = {2017},
  doi     = {10.1016/j.biotechadv.2016.12.005},
  pmid    = {28043897},
  url     = {https://doi.org/10.1016/j.biotechadv.2016.12.005}
}

@article{zhang2016-28005991,
  author  = {Zhang, Ming and Schmitt-Ulms, Gerold and Sato, Christine and Xi, Zhengrui and Zhang, Yalun and Zhou, Ye and George-Hyslop, Peter St and Rogaeva, Ekaterina},
  title   = {{Drug Repositioning for Alzheimer's Disease Based on Systematic 'omics' Data Mining}},
  journal = {PloS one},
  year    = {2016},
  doi     = {10.1371/journal.pone.0168812},
  pmid    = {28005991},
  url     = {https://doi.org/10.1371/journal.pone.0168812}
}

@article{shimada2016-27025079,
  author  = {Shimada, Hiroyuki},
  title   = {{[Significance and progress of DIAN/A4/API]}},
  journal = {Nihon rinsho. Japanese journal of clinical medicine},
  year    = {2016},
  pmid    = {27025079}
}

@article{dasilva2016-26760993,
  author  = {da Silva, Cristiane Bezerra and Pott, Arnildo and Elifio-Esposito, Selene and Dalarmi, Luciane and Nascimento, Kátia Fialho do and Burci, Ligia Moura and de Oliveira, Maislian and Dias, Josiane de Fátima Gaspari and others},
  title   = {{Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2016},
  doi     = {10.3390/molecules21010053},
  pmid    = {26760993},
  url     = {https://doi.org/10.3390/molecules21010053}
}

@article{volpe2016-26559414,
  author  = {Volpe, Roberto and Sotis, Gianluca and Cianciabella, Marta},
  title   = {{Is it always Alzheimer's? Let's talk to our patients about "cardiocerebrovascular" prevention}},
  journal = {Aging clinical and experimental research},
  year    = {2016},
  doi     = {10.1007/s40520-015-0480-7},
  pmid    = {26559414},
  url     = {https://doi.org/10.1007/s40520-015-0480-7}
}

@article{greig2015-26519339,
  author  = {Greig, Sarah L},
  title   = {{Memantine ER/Donepezil: A Review in Alzheimer's Disease}},
  journal = {CNS drugs},
  year    = {2015},
  doi     = {10.1007/s40263-015-0287-2},
  pmid    = {26519339},
  url     = {https://doi.org/10.1007/s40263-015-0287-2}
}

@article{hunter2015-26744739,
  author  = {Hunter, N S and Anderson, K C and Cox, A},
  title   = {{Pimavanserin}},
  journal = {Drugs of today (Barcelona, Spain : 1998)},
  year    = {2015},
  doi     = {10.1358/dot.2015.51.11.2404001},
  pmid    = {26744739},
  url     = {https://doi.org/10.1358/dot.2015.51.11.2404001}
}

@article{corbett2015-25961694,
  author  = {Corbett, Anne and Williams, Gareth and Ballard, Clive},
  title   = {{Drug repositioning in Alzheimer's disease}},
  journal = {Frontiers in bioscience (Scholar edition)},
  year    = {2015},
  doi     = {10.2741/s432},
  pmid    = {25961694},
  url     = {https://doi.org/10.2741/s432}
}

@article{hornberger2015-26231002,
  author  = {Hornberger, John and Michalopoulos, Steven and Dai, Minghan and Andrade, Paula and Dilla, Tatiana and Happich, Michael},
  title   = {{Cost-Effectiveness of Florbetapir-PET in Alzheimer's Disease: A Spanish Societal Perspective}},
  journal = {The journal of mental health policy and economics},
  year    = {2015},
  pmid    = {26231002}
}

@article{toyn2015-25860157,
  author  = {Toyn, Jeremy},
  title   = {{What lessons can be learned from failed Alzheimer's disease trials?}},
  journal = {Expert review of clinical pharmacology},
  year    = {2015},
  doi     = {10.1586/17512433.2015.1034690},
  pmid    = {25860157},
  url     = {https://doi.org/10.1586/17512433.2015.1034690}
}

@article{zhang2015-25446738,
  author  = {Zhang, Xiu-Zhen and Quan, Yuan and Tang, Guang-Yan},
  title   = {{Medical genetics-based drug repurposing for Alzheimer's disease}},
  journal = {Brain research bulletin},
  year    = {2015},
  doi     = {10.1016/j.brainresbull.2014.11.003},
  pmid    = {25446738},
  url     = {https://doi.org/10.1016/j.brainresbull.2014.11.003}
}

@article{panza2014-25081412,
  author  = {Panza, Francesco and Solfrizzi, Vincenzo and Imbimbo, Bruno P and Giannini, Michele and Santamato, Andrea and Seripa, Davide and Logroscino, Giancarlo},
  title   = {{Efficacy and safety studies of gantenerumab in patients with Alzheimer's disease}},
  journal = {Expert review of neurotherapeutics},
  year    = {2014},
  doi     = {10.1586/14737175.2014.945522},
  pmid    = {25081412},
  url     = {https://doi.org/10.1586/14737175.2014.945522}
}

@article{liu2014-24680748,
  author  = {Liu, Junjun and Liu, Shuyu and Tanabe, Chiaki and Maeda, Tomoji and Zou, Kun and Komano, Hiroto},
  title   = {{Differential effects of angiotensin II receptor blockers on Aβ generation}},
  journal = {Neuroscience letters},
  year    = {2014},
  doi     = {10.1016/j.neulet.2014.03.030},
  pmid    = {24680748},
  url     = {https://doi.org/10.1016/j.neulet.2014.03.030}
}

@article{koenig2014-24665414,
  author  = {Koenig, Aaron M and Butters, Meryl A},
  title   = {{Cognition in Late Life Depression: Treatment Considerations}},
  journal = {Current treatment options in psychiatry},
  year    = {2014},
  doi     = {10.1007/s40501-013-0001-2},
  pmid    = {24665414},
  url     = {https://doi.org/10.1007/s40501-013-0001-2}
}

@article{oka2014-25672690,
  author  = {Oka, Yasunori},
  title   = {{[Sleep problems in dementia]}},
  journal = {Rinsho shinkeigaku = Clinical neurology},
  year    = {2014},
  doi     = {10.5692/clinicalneurol.54.994},
  pmid    = {25672690},
  url     = {https://doi.org/10.5692/clinicalneurol.54.994}
}

@article{novakovic2013-24255592,
  author  = {Novakovic, Dijana and Feligioni, Marco and Scaccianoce, Sergio and Caruso, Alessandra and Piccinin, Sonia and Schepisi, Chiara and Errico, Francesco and Mercuri, Nicola B and others},
  title   = {{Profile of gantenerumab and its potential in the treatment of Alzheimer's disease}},
  journal = {Drug design, development and therapy},
  year    = {2013},
  doi     = {10.2147/dddt.s53401},
  pmid    = {24255592},
  url     = {https://doi.org/10.2147/dddt.s53401}
}

@article{riedmann2012-22914446,
  author  = {Riedmann, Eva M},
  title   = {{Two new combination pediatric vaccines advancing to use in infants}},
  journal = {Human vaccines \& immunotherapeutics},
  year    = {2012},
  doi     = {10.4161/hv.21700},
  pmid    = {22914446},
  url     = {https://doi.org/10.4161/hv.21700}
}

@article{young2011-21525515,
  author  = {Young, Allan H},
  title   = {{More good news about the magic ion: lithium may prevent dementia}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2011},
  doi     = {10.1192/bjp.bp.110.082875},
  pmid    = {21525515},
  url     = {https://doi.org/10.1192/bjp.bp.110.082875}
}

@article{jones2010-20836898,
  author  = {Jones, Roy W},
  title   = {{Dimebon disappointment}},
  journal = {Alzheimer's research \& therapy},
  year    = {2010},
  doi     = {10.1186/alzrt49},
  pmid    = {20836898},
  url     = {https://doi.org/10.1186/alzrt49}
}

@article{kerchner2010-20497044,
  author  = {Kerchner, Geoffrey A and Boxer, Adam L},
  title   = {{Bapineuzumab}},
  journal = {Expert opinion on biological therapy},
  year    = {2010},
  doi     = {10.1517/14712598.2010.493872},
  pmid    = {20497044},
  url     = {https://doi.org/10.1517/14712598.2010.493872}
}

@article{pepeu2009-19355843,
  author  = {Pepeu, Giancarlo and Giovannini, Maria Grazia},
  title   = {{Cholinesterase inhibitors and beyond}},
  journal = {Current Alzheimer research},
  year    = {2009},
  doi     = {10.2174/156720509787602861},
  pmid    = {19355843},
  url     = {https://doi.org/10.2174/156720509787602861}
}

@article{prasko2008-19029878,
  author  = {Prasko, Jan},
  title   = {{Bright light therapy}},
  journal = {Neuro endocrinology letters},
  year    = {2008},
  pmid    = {19029878}
}

@article{daiello2007-17633594,
  author  = {Daiello, Lori A},
  title   = {{Atypical antipsychotics for the treatment of dementia-related behaviors: an update}},
  journal = {Medicine and health, Rhode Island},
  year    = {2007},
  pmid    = {17633594}
}

@article{wimo2007-20528433,
  author  = {Wimo, Anders and Norlund, Anders},
  title   = {{Cost-effectiveness of treatments for Alzheimer's dementia}},
  journal = {Expert review of pharmacoeconomics \& outcomes research},
  year    = {2007},
  doi     = {10.1586/14737167.7.1.83},
  pmid    = {20528433},
  url     = {https://doi.org/10.1586/14737167.7.1.83}
}

@article{seltzer2007-17953456,
  author  = {Seltzer, Ben},
  title   = {{Is long-term treatment of Alzheimer's disease with cholinesterase inhibitor therapy justified?}},
  journal = {Drugs \& aging},
  year    = {2007},
  doi     = {10.2165/00002512-200724110-00001},
  pmid    = {17953456},
  url     = {https://doi.org/10.2165/00002512-200724110-00001}
}

@article{onor2007-18044073,
  author  = {Onor, Maria Luisa and Trevisiol, Marianna and Aguglia, Eugenio},
  title   = {{Rivastigmine in the treatment of Alzheimer's disease: an update}},
  journal = {Clinical interventions in aging},
  year    = {2007},
  doi     = {10.2147/ciia.2007.2.1.17},
  pmid    = {18044073},
  url     = {https://doi.org/10.2147/ciia.2007.2.1.17}
}

@article{creeley2008-17112636,
  author  = {Creeley, Catherine E and Wozniak, David F and Nardi, Anthony and Farber, Nuri B and Olney, John W},
  title   = {{Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain}},
  journal = {Neurobiology of aging},
  year    = {2008},
  doi     = {10.1016/j.neurobiolaging.2006.10.020},
  pmid    = {17112636},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2006.10.020}
}

@article{terao2006-16753246,
  author  = {Terao, Takeshi and Nakano, Hideki and Inoue, Yoshiaki and Okamoto, Tatsuya and Nakamura, Jun and Iwata, Noboru},
  title   = {{Lithium and dementia: a preliminary study}},
  journal = {Progress in neuro-psychopharmacology \& biological psychiatry},
  year    = {2006},
  doi     = {10.1016/j.pnpbp.2006.04.020},
  pmid    = {16753246},
  url     = {https://doi.org/10.1016/j.pnpbp.2006.04.020}
}

@article{erkinjuntti2004-15537522,
  author  = {Erkinjuntti, Timo and Román, Gustavo and Gauthier, Serge},
  title   = {{Treatment of vascular dementia--evidence from clinical trials with cholinesterase inhibitors}},
  journal = {Journal of the neurological sciences},
  year    = {2004},
  doi     = {10.1016/j.jns.2004.09.018},
  pmid    = {15537522},
  url     = {https://doi.org/10.1016/j.jns.2004.09.018}
}

@article{prasher2004-15211527,
  author  = {Prasher, V P},
  title   = {{Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population}},
  journal = {International journal of geriatric psychiatry},
  year    = {2004},
  doi     = {10.1002/gps.1077},
  pmid    = {15211527},
  url     = {https://doi.org/10.1002/gps.1077}
}

@article{bonner2002-12171061,
  author  = {Bonner, Lauren T and Peskind, Elaine R},
  title   = {{Pharmacologic treatments of dementia}},
  journal = {The Medical clinics of North America},
  year    = {2002},
  doi     = {10.1016/s0025-7125(02)00007-x},
  pmid    = {12171061},
  url     = {https://doi.org/10.1016/s0025-7125(02)00007-x}
}

@article{crespi2002-12090554,
  author  = {Crespi, Francesco},
  title   = {{Nefiracetam. Daiichi Seiyaku}},
  journal = {Current opinion in investigational drugs (London, England : 2000)},
  year    = {2002},
  pmid    = {12090554}
}

@article{waldemar2001-19811041,
  author  = {Waldemar, G},
  title   = {{Donepezil in the treatment of patients with Alzheimer's disease}},
  journal = {Expert review of neurotherapeutics},
  year    = {2001},
  doi     = {10.1586/14737175.1.1.11},
  pmid    = {19811041},
  url     = {https://doi.org/10.1586/14737175.1.1.11}
}

@article{hughes2001-11735674,
  author  = {Hughes, D A and Walley, T},
  title   = {{Economic evaluations during early (phase II) drug development: a role for clinical trial simulations?}},
  journal = {PharmacoEconomics},
  year    = {2001},
  doi     = {10.2165/00019053-200119110-00001},
  pmid    = {11735674},
  url     = {https://doi.org/10.2165/00019053-200119110-00001}
}

@article{gottfries2001-11824838,
  author  = {Gottfries, C G},
  title   = {{Late life depression}},
  journal = {European archives of psychiatry and clinical neuroscience},
  year    = {2001},
  doi     = {10.1007/bf03035129},
  pmid    = {11824838},
  url     = {https://doi.org/10.1007/bf03035129}
}

@article{molloy2000-10961441,
  author  = {Molloy, D W and Standish, T I},
  title   = {{Clinical experience with Cerebrolysin}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {2000},
  pmid    = {10961441}
}

@article{gottwald1999-11139819,
  author  = {Gottwald, MD and Rozanski, RI},
  title   = {{Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status}},
  journal = {Expert opinion on investigational drugs},
  year    = {1999},
  doi     = {10.1517/13543784.8.10.1673},
  pmid    = {11139819},
  url     = {https://doi.org/10.1517/13543784.8.10.1673}
}

@article{hess1997-9381026,
  author  = {Hess, C W},
  title   = {{[Sleep disorders and dementia]}},
  journal = {Praxis},
  year    = {1997},
  pmid    = {9381026}
}

@article{study1992-0f60ef51,
  title   = {{Dementia: A Clinical Approach}},
  journal = {Annals of Internal Medicine},
  year    = {1992},
  doi     = {10.7326/0003-4819-117-4-351_2},
  url     = {https://doi.org/10.7326/0003-4819-117-4-351_2}
}

@article{study1972-10bc1180,
  title   = {{Dementia Praecox and Paraphrenia}},
  journal = {Annals of Internal Medicine},
  year    = {1972},
  doi     = {10.7326/0003-4819-76-6-1058_8},
  url     = {https://doi.org/10.7326/0003-4819-76-6-1058_8}
}

@article{godyn2016-26721364,
  author  = {Godyń, J. and Jończyk, J. and Panek, D. and Malawska, B.},
  title   = {{Therapeutic strategies for Alzheimer's disease in clinical trials}},
  journal = {Pharmacological reports : PR},
  year    = {2016},
  doi     = {10.1016/j.pharep.2015.07.006},
  pmid    = {26721364},
  url     = {https://doi.org/10.1016/j.pharep.2015.07.006}
}

@article{jacobsen2015-e319eb2f,
  author  = {Jacobsen, Frederick M.},
  title   = {{Second-Generation Antipsychotics and Tardive Syndromes in Affective Illness: A Public Health Problem With Neuropsychiatric Consequences}},
  journal = {American Journal of Public Health},
  year    = {2015},
  doi     = {10.2105/ajph.2014.302439},
  url     = {https://doi.org/10.2105/ajph.2014.302439}
}

@article{nowrangi2015-2d6a6d35,
  author  = {Nowrangi, Milap A and Lyketsos, Constantine G and Rosenberg, Paul B},
  title   = {{Principles and management of neuropsychiatric symptoms in Alzheimer’s dementia}},
  journal = {Alzheimer's Research \& Therapy},
  year    = {2015},
  doi     = {10.1186/s13195-015-0096-3},
  url     = {https://doi.org/10.1186/s13195-015-0096-3}
}

@article{yang2015-25860060,
  author  = {Yang, C. and Xiao, S.},
  title   = {{New developments of clinical trial in immunotherapy for Alzheimer's disease}},
  journal = {Current pharmaceutical biotechnology},
  year    = {2015},
  doi     = {10.2174/138920101606150407112319},
  pmid    = {25860060},
  url     = {https://doi.org/10.2174/138920101606150407112319}
}

@article{zemek2014-24845946,
  author  = {Zemek, F. and Drtinova, L. and Nepovimova, E. and Sepsova, V. and Korabecny, J. and Klimes, J. and Kuca, K.},
  title   = {{Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine}},
  journal = {Expert opinion on drug safety},
  year    = {2014},
  doi     = {10.1517/14740338.2014.914168},
  pmid    = {24845946},
  url     = {https://doi.org/10.1517/14740338.2014.914168}
}

@article{tayeb2013-23574434,
  author  = {Tayeb, H. O. and Murray, E. D. and Price, B. H. and Tarazi, F. I.},
  title   = {{Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive?}},
  journal = {Expert opinion on biological therapy},
  year    = {2013},
  doi     = {10.1517/14712598.2013.789856},
  pmid    = {23574434},
  url     = {https://doi.org/10.1517/14712598.2013.789856}
}

@article{nordberg2013-23930233,
  author  = {Nordberg, A. and Ballard, C. and Bullock, R. and Darreh-Shori, T. and Somogyi, M.},
  title   = {{A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease}},
  journal = {The primary care companion for CNS disorders},
  year    = {2013},
  doi     = {10.4088/pcc.12r01412},
  pmid    = {23930233},
  url     = {https://doi.org/10.4088/pcc.12r01412}
}

@article{anand2013-23435942,
  author  = {Anand, P. and Singh, B.},
  title   = {{A review on cholinesterase inhibitors for Alzheimer's disease}},
  journal = {Archives of pharmacal research},
  year    = {2013},
  doi     = {10.1007/s12272-013-0036-3},
  pmid    = {23435942},
  url     = {https://doi.org/10.1007/s12272-013-0036-3}
}

@article{appleby2013-24059463,
  author  = {Appleby, B. S. and Cummings, J. L.},
  title   = {{Discovering new treatments for Alzheimer's disease by repurposing approved medications}},
  journal = {Current topics in medicinal chemistry},
  year    = {2013},
  doi     = {10.2174/15680266113136660162},
  pmid    = {24059463},
  url     = {https://doi.org/10.2174/15680266113136660162}
}

@article{yiannopoulou2013-23277790,
  author  = {Yiannopoulou, K. G. and Papageorgiou, S. G.},
  title   = {{Current and future treatments for Alzheimer's disease}},
  journal = {Therapeutic advances in neurological disorders},
  year    = {2013},
  doi     = {10.1177/1756285612461679},
  pmid    = {23277790},
  url     = {https://doi.org/10.1177/1756285612461679}
}

@article{olivares2012-21875407,
  author  = {Olivares, D. and Deshpande, V. K. and Shi, Y. and Lahiri, D. K. and Greig, N. H. and Rogers, J. T. and Huang, X.},
  title   = {{N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease}},
  journal = {Current Alzheimer research},
  year    = {2012},
  doi     = {10.2174/156720512801322564},
  pmid    = {21875407},
  url     = {https://doi.org/10.2174/156720512801322564}
}

@article{koh2013-22732440,
  author  = {Koh, M. T. and Rosenzweig-Lipson, S. and Gallagher, M.},
  title   = {{Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment}},
  journal = {Neuropharmacology},
  year    = {2013},
  doi     = {10.1016/j.neuropharm.2012.06.023},
  pmid    = {22732440},
  url     = {https://doi.org/10.1016/j.neuropharm.2012.06.023}
}

@article{salomone2012-22035455,
  author  = {Salomone, S. and Caraci, F. and Leggio, G. M. and Fedotova, J. and Drago, F.},
  title   = {{New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs}},
  journal = {British journal of clinical pharmacology},
  year    = {2012},
  doi     = {10.1111/j.1365-2125.2011.04134.x},
  pmid    = {22035455},
  url     = {https://doi.org/10.1111/j.1365-2125.2011.04134.x}
}

@article{bolea2011-22023459,
  author  = {Bolea, I. and Juárez-Jiménez, J. and de Los Ríos, C. and Chioua, M. and Pouplana, R. and Luque, F. J. and Unzeta, M. and Marco-Contelles, J. and others},
  title   = {{Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease}},
  journal = {Journal of medicinal chemistry},
  year    = {2011},
  doi     = {10.1021/jm200853t},
  pmid    = {22023459},
  url     = {https://doi.org/10.1021/jm200853t}
}

@article{shepardson2011-21987540,
  author  = {Shepardson, N. E. and Shankar, G. M. and Selkoe, D. J.},
  title   = {{Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2011.203},
  pmid    = {21987540},
  url     = {https://doi.org/10.1001/archneurol.2011.203}
}

@article{pohanka2011-22286807,
  author  = {Pohanka, M.},
  title   = {{Cholinesterases, a target of pharmacology and toxicology}},
  journal = {Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia},
  year    = {2011},
  doi     = {10.5507/bp.2011.036},
  pmid    = {22286807},
  url     = {https://doi.org/10.5507/bp.2011.036}
}

@article{hutson2011-21619887,
  author  = {Hutson, P. H. and Finger, E. N. and Magliaro, B. C. and Smith, S. M. and Converso, A. and Sanderson, P. E. and Mullins, D. and Hyde, L. A. and others},
  title   = {{The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents}},
  journal = {Neuropharmacology},
  year    = {2011},
  doi     = {10.1016/j.neuropharm.2011.05.009},
  pmid    = {21619887},
  url     = {https://doi.org/10.1016/j.neuropharm.2011.05.009}
}

@article{samadi2011-21504387,
  author  = {Samadi, H. and Sultzer, D.},
  title   = {{Solanezumab for Alzheimer's disease}},
  journal = {Expert opinion on biological therapy},
  year    = {2011},
  doi     = {10.1517/14712598.2011.578573},
  pmid    = {21504387},
  url     = {https://doi.org/10.1517/14712598.2011.578573}
}

@article{rissman2011-21388375,
  author  = {Rissman, R. A. and Mobley, W. C.},
  title   = {{Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2011},
  doi     = {10.1111/j.1471-4159.2011.07237.x},
  pmid    = {21388375},
  url     = {https://doi.org/10.1111/j.1471-4159.2011.07237.x}
}

@article{xia2010-20720132,
  author  = {Xia, P. and Chen, H. S. and Zhang, D. and Lipton, S. A.},
  title   = {{Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2010},
  doi     = {10.1523/jneurosci.2488-10.2010},
  pmid    = {20720132},
  url     = {https://doi.org/10.1523/jneurosci.2488-10.2010}
}

@article{gauthier2010-20096151,
  author  = {Gauthier, S. and Cummings, J. and Ballard, C. and Brodaty, H. and Grossberg, G. and Robert, P. and Lyketsos, C.},
  title   = {{Management of behavioral problems in Alzheimer's disease}},
  journal = {International psychogeriatrics},
  year    = {2010},
  doi     = {10.1017/s1041610209991505},
  pmid    = {20096151},
  url     = {https://doi.org/10.1017/s1041610209991505}
}

@article{sanchezbarcelo2010-20423309,
  author  = {Sánchez-Barceló, E. J. and Mediavilla, M. D. and Tan, D. X. and Reiter, R. J.},
  title   = {{Clinical uses of melatonin: evaluation of human trials}},
  journal = {Current medicinal chemistry},
  year    = {2010},
  doi     = {10.2174/092986710791233689},
  pmid    = {20423309},
  url     = {https://doi.org/10.2174/092986710791233689}
}

@article{young2009-19523343,
  author  = {Young, W.},
  title   = {{Review of lithium effects on brain and blood}},
  journal = {Cell transplantation},
  year    = {2009},
  doi     = {10.3727/096368909x471251},
  pmid    = {19523343},
  url     = {https://doi.org/10.3727/096368909x471251}
}

@article{kotermanski2009-19261873,
  author  = {Kotermanski, S. E. and Johnson, J. W.},
  title   = {{Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.3703-08.2009},
  pmid    = {19261873},
  url     = {https://doi.org/10.1523/jneurosci.3703-08.2009}
}

@article{beaulieu2009-18928402,
  author  = {Beaulieu, J. M. and Gainetdinov, R. R. and Caron, M. G.},
  title   = {{Akt/GSK3 signaling in the action of psychotropic drugs}},
  journal = {Annual review of pharmacology and toxicology},
  year    = {2009},
  doi     = {10.1146/annurev.pharmtox.011008.145634},
  pmid    = {18928402},
  url     = {https://doi.org/10.1146/annurev.pharmtox.011008.145634}
}

@article{wilson2008-18291351,
  author  = {Wilson, B. and Samanta, M. K. and Santhi, K. and Kumar, K. P. and Paramakrishnan, N. and Suresh, B.},
  title   = {{Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease}},
  journal = {Brain research},
  year    = {2008},
  doi     = {10.1016/j.brainres.2008.01.039},
  pmid    = {18291351},
  url     = {https://doi.org/10.1016/j.brainres.2008.01.039}
}

@article{munoztorrero2008-18855672,
  author  = {Muñoz-Torrero, D.},
  title   = {{Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease}},
  journal = {Current medicinal chemistry},
  year    = {2008},
  doi     = {10.2174/092986708785909067},
  pmid    = {18855672},
  url     = {https://doi.org/10.2174/092986708785909067}
}

@article{bolognesi2007-18047264,
  author  = {Bolognesi, M. L. and Cavalli, A. and Valgimigli, L. and Bartolini, M. and Rosini, M. and Andrisano, V. and Recanatini, M. and Melchiorre, C.},
  title   = {{Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease}},
  journal = {Journal of medicinal chemistry},
  year    = {2007},
  doi     = {10.1021/jm701225u},
  pmid    = {18047264},
  url     = {https://doi.org/10.1021/jm701225u}
}

@article{wang2007-17965777,
  author  = {Wang, J. and Ho, L. and Chen, L. and Zhao, Z. and Zhao, W. and Qian, X. and Humala, N. and Seror, I. and others},
  title   = {{Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2007},
  doi     = {10.1172/jci31547},
  pmid    = {17965777},
  url     = {https://doi.org/10.1172/jci31547}
}

@article{parsons2007-17904591,
  author  = {Parsons, C. G. and Stöffler, A. and Danysz, W.},
  title   = {{Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse}},
  journal = {Neuropharmacology},
  year    = {2007},
  doi     = {10.1016/j.neuropharm.2007.07.013},
  pmid    = {17904591},
  url     = {https://doi.org/10.1016/j.neuropharm.2007.07.013}
}

@article{pangalos2007-17599084,
  author  = {Pangalos, M. N. and Schechter, L. E. and Hurko, O.},
  title   = {{Drug development for CNS disorders: strategies for balancing risk and reducing attrition}},
  journal = {Nature reviews. Drug discovery},
  year    = {2007},
  doi     = {10.1038/nrd2094},
  pmid    = {17599084},
  url     = {https://doi.org/10.1038/nrd2094}
}

@article{seltzer2007-17472546,
  author  = {Seltzer, Ben},
  title   = {{Donepezil: an update}},
  journal = {Expert Opinion on Pharmacotherapy},
  year    = {2007},
  doi     = {10.1517/14656566.8.7.1011},
  pmid    = {17472546},
  url     = {https://doi.org/10.1517/14656566.8.7.1011}
}

@article{chen2006-16805772,
  author  = {Chen, H. S. and Lipton, S. A.},
  title   = {{The chemical biology of clinically tolerated NMDA receptor antagonists}},
  journal = {Journal of neurochemistry},
  year    = {2006},
  doi     = {10.1111/j.1471-4159.2006.03991.x},
  pmid    = {16805772},
  url     = {https://doi.org/10.1111/j.1471-4159.2006.03991.x}
}

@article{lipton2006-16424917,
  author  = {Lipton, S. A.},
  title   = {{Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond}},
  journal = {Nature reviews. Drug discovery},
  year    = {2006},
  doi     = {10.1038/nrd1958},
  pmid    = {16424917},
  url     = {https://doi.org/10.1038/nrd1958}
}

@article{johnson2006-16368266,
  author  = {Johnson, J. W. and Kotermanski, S. E.},
  title   = {{Mechanism of action of memantine}},
  journal = {Current opinion in pharmacology},
  year    = {2006},
  doi     = {10.1016/j.coph.2005.09.007},
  pmid    = {16368266},
  url     = {https://doi.org/10.1016/j.coph.2005.09.007}
}

@article{francis2005-16273023,
  author  = {Francis, P. T.},
  title   = {{The interplay of neurotransmitters in Alzheimer's disease}},
  journal = {CNS spectrums},
  year    = {2005},
  doi     = {10.1017/s1092852900014164},
  pmid    = {16273023},
  url     = {https://doi.org/10.1017/s1092852900014164}
}

@article{groves2005-15820552,
  author  = {Groves, D. A. and Brown, V. J.},
  title   = {{Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2005},
  doi     = {10.1016/j.neubiorev.2005.01.004},
  pmid    = {15820552},
  url     = {https://doi.org/10.1016/j.neubiorev.2005.01.004}
}

@article{lipton2005-15974913,
  author  = {Lipton, S. A.},
  title   = {{The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism}},
  journal = {Current Alzheimer research},
  year    = {2005},
  doi     = {10.2174/1567205053585846},
  pmid    = {15974913},
  url     = {https://doi.org/10.2174/1567205053585846}
}

@article{dzau2005-15821452,
  author  = {Dzau, Victor J.},
  title   = {{The cardiovascular continuum and renin–angiotensin–aldosterone system blockade}},
  journal = {Journal of Hypertension},
  year    = {2005},
  doi     = {10.1097/01.hjh.0000165623.72310.dd},
  pmid    = {15821452},
  url     = {https://doi.org/10.1097/01.hjh.0000165623.72310.dd}
}

@article{houghton2005-15956811,
  author  = {Houghton, P. J. and Howes, M. J.},
  title   = {{Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease}},
  journal = {Neuro-Signals},
  year    = {2005},
  doi     = {10.1159/000085382},
  pmid    = {15956811},
  url     = {https://doi.org/10.1159/000085382}
}

@article{racchi2004-15304241,
  author  = {Racchi, M. and Mazzucchelli, M. and Porrello, E. and Lanni, C. and Govoni, S.},
  title   = {{Acetylcholinesterase inhibitors: novel activities of old molecules}},
  journal = {Pharmacological research},
  year    = {2004},
  doi     = {10.1016/j.phrs.2003.12.027},
  pmid    = {15304241},
  url     = {https://doi.org/10.1016/j.phrs.2003.12.027}
}

@article{erkinjuntti2004-15001795,
  author  = {Erkinjuntti, Timo and Román, Gustavo C. and Gauthier, Serge G. and Feldman, Howard and Rockwood, Kenneth J.},
  title   = {{Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment}},
  journal = {Stroke},
  year    = {2004},
  doi     = {10.1161/01.str.0000120731.88236.33},
  pmid    = {15001795},
  url     = {https://doi.org/10.1161/01.str.0000120731.88236.33}
}

@article{wilkinson2004-15132713,
  author  = {Wilkinson, D. G. and Francis, P. T. and Schwam, E. and Payne-Parrish, J.},
  title   = {{Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy}},
  journal = {Drugs \& aging},
  year    = {2004},
  doi     = {10.2165/00002512-200421070-00004},
  pmid    = {15132713},
  url     = {https://doi.org/10.2165/00002512-200421070-00004}
}

@article{danysz2003-12973747,
  author  = {Danysz, W. and Parsons, C. G.},
  title   = {{The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence}},
  journal = {International journal of geriatric psychiatry},
  year    = {2003},
  doi     = {10.1002/gps.938},
  pmid    = {12973747},
  url     = {https://doi.org/10.1002/gps.938}
}

@article{boeve2003-14592300,
  author  = {Boeve, B. F. and Silber, M. H. and Ferman, T. J.},
  title   = {{Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients}},
  journal = {Sleep medicine},
  year    = {2003},
  doi     = {10.1016/s1389-9457(03)00072-8},
  pmid    = {14592300},
  url     = {https://doi.org/10.1016/s1389-9457(03)00072-8}
}

@article{grossberg2003-24944370,
  author  = {Grossberg, G. T.},
  title   = {{Cholinesterase inhibitors for the treatment of Alzheimer's disease:: getting on and staying on}},
  journal = {Current therapeutic research, clinical and experimental},
  year    = {2003},
  doi     = {10.1016/s0011-393x(03)00059-6},
  pmid    = {24944370},
  url     = {https://doi.org/10.1016/s0011-393x(03)00059-6}
}

@article{samochocki2003-12649296,
  author  = {Samochocki, M. and Höffle, A. and Fehrenbacher, A. and Jostock, R. and Ludwig, J. and Christner, C. and Radina, M. and Zerlin, M. and others},
  title   = {{Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors}},
  journal = {The Journal of pharmacology and experimental therapeutics},
  year    = {2003},
  doi     = {10.1124/jpet.102.045773},
  pmid    = {12649296},
  url     = {https://doi.org/10.1124/jpet.102.045773}
}

@article{rogawski2003-14530799,
  author  = {Rogawski, M. A. and Wenk, G. L.},
  title   = {{The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease}},
  journal = {CNS drug reviews},
  year    = {2003},
  doi     = {10.1111/j.1527-3458.2003.tb00254.x},
  pmid    = {14530799},
  url     = {https://doi.org/10.1111/j.1527-3458.2003.tb00254.x}
}

@article{lopez2002-12270757,
  author  = {López, S. and Bastida, J. and Viladomat, F. and Codina, C.},
  title   = {{Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts}},
  journal = {Life sciences},
  year    = {2002},
  doi     = {10.1016/s0024-3205(02)02034-9},
  pmid    = {12270757},
  url     = {https://doi.org/10.1016/s0024-3205(02)02034-9}
}

@article{baron2002-11888271,
  author  = {Bar-On, P. and Millard, C. B. and Harel, M. and Dvir, H. and Enz, A. and Sussman, J. L. and Silman, I.},
  title   = {{Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine}},
  journal = {Biochemistry},
  year    = {2002},
  doi     = {10.1021/bi020016x},
  pmid    = {11888271},
  url     = {https://doi.org/10.1021/bi020016x}
}

@article{pollock2002-11870012,
  author  = {Pollock, Bruce G. and Mulsant, Benoit H. and Rosen, Jules and Sweet, Robert A. and Mazumdar, Sati and Bharucha, Ashok J. and Marin, Robert S. and Jacob, N. J. and others},
  title   = {{Comparison of Citalopram, Perphenazine, and Placebo for the Acute Treatment of Psychosis and Behavioral Disturbances in Hospitalized, Demented Patients}},
  journal = {American Journal of Psychiatry},
  year    = {2002},
  doi     = {10.1176/appi.ajp.159.3.460},
  pmid    = {11870012},
  url     = {https://doi.org/10.1176/appi.ajp.159.3.460}
}

@article{greig2002-12636181,
  author  = {Greig, N. H. and Lahiri, D. K. and Sambamurti, K.},
  title   = {{Butyrylcholinesterase: an important new target in Alzheimer's disease therapy}},
  journal = {International psychogeriatrics},
  year    = {2002},
  doi     = {10.1017/s1041610203008676},
  pmid    = {12636181},
  url     = {https://doi.org/10.1017/s1041610203008676}
}

@article{jann2002-12162759,
  author  = {Jann, M. W. and Shirley, K. L. and Small, G. W.},
  title   = {{Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors}},
  journal = {Clinical pharmacokinetics},
  year    = {2002},
  doi     = {10.2165/00003088-200241100-00003},
  pmid    = {12162759},
  url     = {https://doi.org/10.2165/00003088-200241100-00003}
}

@article{ballard2002-11803198,
  author  = {Ballard, C. G.},
  title   = {{Advances in the treatment of Alzheimer's disease: benefits of dual cholinesterase inhibition}},
  journal = {European neurology},
  year    = {2002},
  doi     = {10.1159/000047952},
  pmid    = {11803198},
  url     = {https://doi.org/10.1159/000047952}
}

@article{maelicke2001-11230879,
  author  = {Maelicke, A. and Samochocki, M. and Jostock, R. and Fehrenbacher, A. and Ludwig, J. and Albuquerque, E. X. and Zerlin, M.},
  title   = {{Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease}},
  journal = {Biological psychiatry},
  year    = {2001},
  doi     = {10.1016/s0006-3223(00)01109-4},
  pmid    = {11230879},
  url     = {https://doi.org/10.1016/s0006-3223(00)01109-4}
}

@article{greig2001-11900310,
  author  = {Greig, N. H. and Utsuki, T. and Yu, Q. and Zhu, X. and Holloway, H. W. and Perry, T. and Lee, B. and Ingram, D. K. and others},
  title   = {{A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase}},
  journal = {Current medical research and opinion},
  year    = {2001},
  doi     = {10.1185/0300799039117057},
  pmid    = {11900310},
  url     = {https://doi.org/10.1185/0300799039117057}
}

@article{vitiello2001-11602004,
  author  = {Vitiello, M. V. and Borson, S.},
  title   = {{Sleep disturbances in patients with Alzheimer's disease: epidemiology, pathophysiology and treatment}},
  journal = {CNS drugs},
  year    = {2001},
  doi     = {10.2165/00023210-200115100-00004},
  pmid    = {11602004},
  url     = {https://doi.org/10.2165/00023210-200115100-00004}
}

@article{sugimoto2000-10637367,
  author  = {Sugimoto, H. and Yamanishi, Y. and Iimura, Y. and Kawakami, Y.},
  title   = {{Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors}},
  journal = {Current medicinal chemistry},
  year    = {2000},
  doi     = {10.2174/0929867003375191},
  pmid    = {10637367},
  url     = {https://doi.org/10.2174/0929867003375191}
}

@article{francis1999-10071091,
  author  = {Francis, P. T. and Palmer, A. M. and Snape, M. and Wilcock, G. K.},
  title   = {{The cholinergic hypothesis of Alzheimer's disease: a review of progress}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {1999},
  doi     = {10.1136/jnnp.66.2.137},
  pmid    = {10071091},
  url     = {https://doi.org/10.1136/jnnp.66.2.137}
}

@article{arnsten1999-9894572,
  author  = {Arnsten, A. F. and Mathew, R. and Ubriani, R. and Taylor, JR. and Li, B. M.},
  title   = {{Alpha-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function}},
  journal = {Biological psychiatry},
  year    = {1999},
  doi     = {10.1016/s0006-3223(98)00296-0},
  pmid    = {9894572},
  url     = {https://doi.org/10.1016/s0006-3223(98)00296-0}
}

@article{nordberg1998-9880090,
  author  = {Nordberg, A. and Svensson, A. L.},
  title   = {{Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology}},
  journal = {Drug safety},
  year    = {1998},
  doi     = {10.2165/00002018-199819060-00004},
  pmid    = {9880090},
  url     = {https://doi.org/10.2165/00002018-199819060-00004}
}

@article{polinsky1998-9737824,
  author  = {Polinsky, R. J.},
  title   = {{Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease}},
  journal = {Clinical therapeutics},
  year    = {1998},
  doi     = {10.1016/s0149-2918(98)80127-6},
  pmid    = {9737824},
  url     = {https://doi.org/10.1016/s0149-2918(98)80127-6}
}

@article{millard1995-7722478,
  author  = {Millard, C. B. and Broomfield, C. A.},
  title   = {{Anticholinesterases: medical applications of neurochemical principles}},
  journal = {Journal of neurochemistry},
  year    = {1995},
  doi     = {10.1046/j.1471-4159.1995.64051909.x},
  pmid    = {7722478},
  url     = {https://doi.org/10.1046/j.1471-4159.1995.64051909.x}
}

@article{lawrence1995-8534423,
  author  = {Lawrence, A. D. and Sahakian, B. J.},
  title   = {{Alzheimer disease, attention, and the cholinergic system}},
  journal = {Alzheimer disease and associated disorders},
  year    = {1995},
  doi     = {10.1097/00002093-199501002-00008},
  pmid    = {8534423},
  url     = {https://doi.org/10.1097/00002093-199501002-00008}
}

@article{owens1994-7508830,
  author  = {Owens, M. J. and Nemeroff, C. B.},
  title   = {{Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter}},
  journal = {Clinical chemistry},
  year    = {1994},
  doi     = {10.1093/clinchem/40.2.288},
  pmid    = {7508830},
  url     = {https://doi.org/10.1093/clinchem/40.2.288}
}

@article{kornhuber1994-7884411,
  author  = {Kornhuber, Johannes and Weller, Michael and Schoppmeyer, K. and Riederer, P.},
  title   = {{Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties}},
  journal = {PubMed},
  year    = {1994},
  pmid    = {7884411}
}

@article{larson1992-1599598,
  author  = {Larson, E. B. and Kukull, W. A. and Katzman, R. L.},
  title   = {{Cognitive impairment: dementia and Alzheimer's disease}},
  journal = {Annual review of public health},
  year    = {1992},
  doi     = {10.1146/annurev.pu.13.050192.002243},
  pmid    = {1599598},
  url     = {https://doi.org/10.1146/annurev.pu.13.050192.002243}
}

@article{starostarubinstein1987-3827691,
  author  = {Starosta-Rubinstein, S. and Young, A. B. and Kluin, K. and Hill, G. and Aisen, A. M. and Gabrielsen, T. and Brewer, G. J.},
  title   = {{Clinical assessment of 31 patients with Wilson's disease. Correlations with structural changes on magnetic resonance imaging}},
  journal = {Archives of neurology},
  year    = {1987},
  doi     = {10.1001/archneur.1987.00520160007005},
  pmid    = {3827691},
  url     = {https://doi.org/10.1001/archneur.1987.00520160007005}
}

@article{davies1979-37989,
  author  = {Davies, P.},
  title   = {{Neurotransmitter-related enzymes in senile dementia of the Alzheimer type}},
  journal = {Brain research},
  year    = {1979},
  doi     = {10.1016/0006-8993(79)90336-6},
  pmid    = {37989},
  url     = {https://doi.org/10.1016/0006-8993(79)90336-6}
}

@article{perry1977-144789,
  author  = {Perry, E. K. and Gibson, P. H. and Blessed, G. and Perry, R. H. and Tomlinson, B. E.},
  title   = {{Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue}},
  journal = {Journal of the neurological sciences},
  year    = {1977},
  doi     = {10.1016/0022-510x(77)90073-9},
  pmid    = {144789},
  url     = {https://doi.org/10.1016/0022-510x(77)90073-9}
}

@article{ninsiima2026-da71abad,
  author  = {Ninsiima, H. I. and Daniel, E. E. and Kisakye, I. N. and Mandera, I. and Ainamani, H. E. and Akambasisa, M. and Ayebazibwe, G. and Matovu, D.},
  title   = {{Interventions for Cognitive Impairment in Type 2 Diabetes Mellitus: An Umbrella Review of Pharmacological and Lifestyle Strategies, Mechanisms, and Clinical Implications}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.23.26366288},
  url     = {https://doi.org/10.64898/2026.10.23.26366288}
}

@article{fox2026-7db41b34,
  author  = {Fox, S. A. and Taylor, J. D. and Rolan, P. E. and Ritchie, C. W. and Seckl, J. and Hilt, D. C.},
  title   = {{The Role of Cortisol in CNS Disease –11β-HSD1 Inhibition as a Potential New Therapeutic Strategy for Alzheimer’s Disease and Major Depressive Disorder}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202610.1646.v1},
  url     = {https://doi.org/10.20944/preprints202610.1646.v1}
}

@article{hampilos2026-4a696e60,
  author  = {Hampilos, N. H. and Campion, T. R. and Sholle, E. and Zang, C. and Glodzik, L. and Butler, T. A. and Ndhlovu, L. C.},
  title   = {{Individual Angiotensin Receptor Blockers and Risk of Dementia: A Target Trial Emulation Study}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.13.26365306},
  url     = {https://doi.org/10.64898/2026.10.13.26365306}
}

@article{singh2026-628d86a7,
  author  = {Singh, V. and Sharma, R. and Sharma, M. and Wiegmann, T.},
  title   = {{Dementia and PDE5 inhibitors: A retrospective cohort study of veterans}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11010754/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11010754/v1}
}

@article{nago2026-f876eb5b,
  author  = {Nago, B. and Qu, C.},
  title   = {{Simulating the Effects of Gamma Oscillation Treatment on Selective Neurotransmitters Using The Virtual Brain and Complex Pathway Simulator}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11199141/v2},
  url     = {https://doi.org/10.21203/rs.3.rs-11199141/v2}
}

@article{alnusair2026-96e671cd,
  author  = {Al-Nusair, M. and Haddad, T. A. and Khurana, S. and Al-Nusair, J.},
  title   = {{Cognitive and Renal Outcomes of Finerenone in Older Adults With Heart Failure With Preserved Ejection Fraction: A Real-World Cohort Study}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11263755/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11263755/v1}
}

@article{brooks2026-82f57b8f,
  author  = {Brooks, J. D. and Donahue, M. A. and ElHassan, A. and Tian, J. and Hernandez-Diaz, S. and Blacker, D. and Estiri, H. and Haas, J. S. and others},
  title   = {{Patterns of GLP-1 Receptor Agonist Initiation Compared With Other Glucose-Lowering and Anti-Obesity Therapies Among Older Adults}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.29.26364340},
  url     = {https://doi.org/10.64898/2026.09.29.26364340}
}

@article{ejaz2026-f06e02fb,
  author  = {Ejaz, M. M. and Iftikhar, H. and Al-Namshah, K. and Khan, S. and Ashraf, S. and Meer, N. and Riaz, M. and Saleem, M. and others},
  title   = {{Substituent Effects on Electronic Properties and Acetylcholinesterase Inhibitory Potential of Donepezil Analogues: A DFT, Molecular Docking, and ADMET Study with Dynamics Validation of the Lead Candidate}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11082767/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11082767/v1}
}

@article{dange2026-86ec91fb,
  author  = {Dange¹, R. T. and Jadhav², S. B. and RAj, rupali},
  title   = {{Docking-Guided Design and Biological Evaluation of a Lead Convolvine-Based Acetylcholinesterase Inhibitor for Alzheimer's Disease}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10890265/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10890265/v1}
}

@article{jairamani2026-de94ca0a,
  author  = {Jairamani, S. and Umar, M. and Baig, M. M. A. and Qadri, M. and Rathi, D. and Sahil, F. and Amin, J. H. J. and Rana, J. S.},
  title   = {{Changing Landscape of Alzheimer’s Disease Mortality in the United States (1979– 2023): A CDC WONDER Analysis of Epidemiological Shifts, Disparities and ARIMA-Based Projections to 2050}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10697406/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10697406/v1}
}

@article{zaareer2026-bd508402,
  author  = {Za'areer, M. A. and Jafari, A. A.},
  title   = {{Neuropsychiatric Adverse-Event Reporting With Brexpiprazole Across Approved Indications: A Disproportionality Analysis Using the FDA Adverse Event Reporting System (FAERS)}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10907540/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10907540/v1}
}

@article{liu2026-6e68a0ab,
  author  = {Liu, J. and Yuan, H.},
  title   = {{Early strong anticholinergic initiation and 30-day mortality in older inpatients with dementia: a target trial emulation}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10644330/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10644330/v1}
}

@article{ban2026-0ffeafec,
  author  = {Ban, K. and Kajiwara, S. and Hashizume, T. and Ninomiya, M. and Koketsu, M.},
  title   = {{Structural optimization of coumarin-pyridine hybrid derivative salts as potent acetylcholinesterase inhibitors}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10583076/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10583076/v1}
}

@article{arai2026-fb45f8a8,
  author  = {Arai, M. and Yue, J. and Shams, E. and Stevens, C. J. and Han, H. and Gibson, R. and Yildirim, T. and Feldman, H. H. and others},
  title   = {{Chronic trazodone treatment consolidates sleep, improves memory, and reduces amyloid pathology in a mouse model of Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.20.746036},
  url     = {https://doi.org/10.64898/2026.08.20.746036}
}

@article{hey2026-a02492d7,
  author  = {Hey, J. A. and Geerts, H. and Schaefer, J. F. and Short, S. M. and Graaf, P. and Abushakra, S. and Power, A. and Tolar, M. and others},
  title   = {{Quantitative Systems Pharmacology Analysis of Amyloid Aggregation and Hippocampal Atrophy Trajectories in Alzheimer’s Disease by APOE4 Genotype and Valiltramiprosate/ALZ-801 Treatment}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10570608/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10570608/v1}
}

@article{wallis2026-05fbee68,
  author  = {Wallis, K. and McDonald, S. and King, D. B. and Liu, C. and van Leeuwen, E. and Moncrieff, J. and Horowitz, M. and Waller, M. and others},
  title   = {{Long-term antidepressant use and outcomes in adults: A systematic review}},
  journal = {PsyArXiv},
  year    = {2026},
  doi     = {10.31234/osf.io/s4ej8_v1},
  url     = {https://doi.org/10.31234/osf.io/s4ej8_v1}
}

@article{baral2026-e2e1ba0c,
  author  = {Baral, D. S. and Verma, R.},
  title   = {{Exploring the Molecular and Biochemical Mechanisms of Aromasin in Modulating COX-2/iNOS for Alzheimer’s Disease-Associated Synaptic Dysfunction: An In Silico Drug Repurposing Study}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10701602/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10701602/v1}
}

@article{takechi2026-25853c66,
  author  = {Takechi, R. and Dunne, J. and Lam, V. and Stephan, B. M. and Pereira, G. and Clarnette, R. and Watts, G. F. and Flicker, L. and others},
  title   = {{Repurposing probucol for prevention of dementia: a nationwide cohort study}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10311061/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10311061/v1}
}

@article{wander2026-f474ce0b,
  author  = {Wander, P. L. and Doherty, L. and Pan, Q. and Carmichael, O. and Turner, R. and Kuo, S. and Munshi, M. and Wallia, A. and others},
  title   = {{Randomized metformin and cognitive outcomes in the Diabetes Prevention Program Outcomes Study}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.05.26359234},
  url     = {https://doi.org/10.64898/2026.08.05.26359234}
}

@article{rautela2026-3e3bf661,
  author  = {Rautela, R. and Gupta, S. M. and Gaurav, A.},
  title   = {{Discovery of Natural Cholinesterase Inhibitors via Integrated Computational Studies using Labdane-Related Diterpenoids-based Pharmacophore Model and in-vitro studies}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10417596/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10417596/v1}
}

@article{vanderveere2026-b4afa458,
  author  = {van der Veere, P. and Broulikova, H. and Handels, R. and Teunissen, C. and Collij, L. and Vijverberg, E. and van der Flier, W. and Berkhof, J.},
  title   = {{Cost-effectiveness of amyloid-targeting therapies in a memory clinic population; a simulation study}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.30.26359218},
  url     = {https://doi.org/10.64898/2026.07.30.26359218}
}

@article{rathi2026-2e030f13,
  author  = {Rathi, R.},
  title   = {{Computational Screening of FDA-Approved Drugs as Potential BACE1 Inhibitors for Alzheimer's Disease Drug Repurposing}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10465925/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10465925/v1}
}

@article{copeland2026-408c21ca,
  author  = {Copeland, M. H. and Youngstrom, D. E. and Konrad, K. S. and Diering, G. H. and Letsinger, A. C. and Aksu, L. R. and Yakel, J. L. and Cushman, J. D.},
  title   = {{Diphenhydramine Disrupts Sleep Architecture in 5XFAD Alzheimer’s Disease Model and Wild-Type Mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.22.739929},
  url     = {https://doi.org/10.64898/2026.07.22.739929}
}

@article{nakashima2026-086b7a5e,
  author  = {Nakashima, S. and Sato, K. and Niimi, Y. and Satake, W. and Iwatsubo, T.},
  title   = {{Comparator supplement patterns qualify the clinical interpretation of an EHR-derived glucosamine signal in Alzheimer’s disease}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.23.26358748},
  url     = {https://doi.org/10.64898/2026.07.23.26358748}
}

@article{silva2026-e092d390,
  author  = {Silva, L. L. and Valverde, M. E. S. and Silva, A. M. P. and Braz, L. D. G. and da Silva, K. K. and Aguiar, E. M. and Volta, V. D. and de Oliveira, C. and others},
  title   = {{GLP-1 Receptor Agonists vs SGLT2 Inhibitors for Alzheimer’s Disease Risk in Type 2 Diabetes: A Systematic Review and Meta-Analysis}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.22.26358702},
  url     = {https://doi.org/10.64898/2026.07.22.26358702}
}

@article{xu2026-e1b89ac2,
  author  = {Xu, Y. and Shi, J. and Andrews, R. and Derington, C. G. and Greene, T. and Scharfstein, D. and Berchie, R. and Supiano, M. and others},
  title   = {{Effect of initiating an ARB- versus ACEI-based regimen on dementia risk, a target trial emulation of 2.5 million US Veterans}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.05.26357173},
  url     = {https://doi.org/10.64898/2026.07.05.26357173}
}

@article{sato2026-a8cec4bf,
  author  = {Sato, K. and Niimi, Y. and Nakashima, S. and Igarashi, A. and Iwata, A. and Kasuga, K. and Nemoto, K. and Higashi, S. and others},
  title   = {{Protocol for the 2026 Nationwide Survey of Dementia Specialists on the Real-World Implementation of Anti-Amyloid Antibody Therapies in Japan: Clinical Practice, Blood Biomarkers, and Preference Experiments}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.06.30.26356494},
  url     = {https://doi.org/10.64898/2026.06.30.26356494}
}

@article{atmaca2026-4235e404,
  author  = {Atmaca, H. and DÇ, Gürbüz and Erol, M. K. and Yetkin, E.},
  title   = {{Amantadine, Donepezil and Memantine Associated Arrhythmia in an Elderly Patient}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-9807496/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-9807496/v1}
}

@article{knudson2026-59dea31b,
  author  = {Knudson, K. C. and Anderson, K. M. and Ballard, M. and Lenz, R. A. and Dam, T. and Sagman, D. and Brandon, N. J. and Banerjee, T. and others},
  title   = {{Reducing placebo response in clinical trials of agitation in Alzheimer’s disease}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.06.03.26354808},
  url     = {https://doi.org/10.64898/2026.06.03.26354808}
}

@article{wang2026-7bc8dc76,
  author  = {Wang, Y. and Li, L. and Zhe, L. and Zhang, S. and Jiao, Y. and Li, F.},
  title   = {{Assessment of potentially inappropriate medications using STOPPFrail V2 criteria and OncPal guideline in elderly cancer patients with end-stage disease: A cross-sectional study}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-9733500/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-9733500/v1}
}

@article{ferreiraatuesta2026-62a1a01d,
  author  = {Ferreira-Atuesta, C. and Schubert, K. M. and Tai, X. Y. and Noain, D. and Skwarzynska, D. and Wyss, M. T. and Schreiner, S. J. and Jung, H. H. and others},
  title   = {{Sodium channel blockers are associated with reduced dementia risk in late-onset unexplained epilepsy}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.05.20.26353714},
  url     = {https://doi.org/10.64898/2026.05.20.26353714}
}

@article{ahmed2026-e5966415,
  author  = {Ahmed, A. and k, Almutari},
  title   = {{Beyond Cardiology's Pillars: A Network Meta-Analysis Comparing the Recombinant Zoster Vaccine (Shingrix/RZV) with SGLT2 Inhibitors and GLP-1 Receptor Agonists for Prevention of Major Adverse Cardiovascular Events and Dementia in Adults Aged ≥50 Years}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-9727771/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-9727771/v1}
}

@article{sen2026-e890aa4f,
  author  = {Sen, S. E.},
  title   = {{A Transferable Health Economic Evaluation Framework for Alzheimer’s Disease-Modifying Therapies}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-9602832/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-9602832/v1}
}

@article{murugadoss2026-8d55012e,
  author  = {Murugadoss, K. and Venkatakrishnan, A. and Soundararajan, V.},
  title   = {{Legacy neuropsychiatric benefit after semaglutide is linked to maximum achieved dose and independent of the maximum weight lost}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.04.16.26351060},
  url     = {https://doi.org/10.64898/2026.04.16.26351060}
}

@article{dedebant2026-f682c193,
  author  = {Dedebant, E. and Even, M. and Törnqvist, M. and Hauw, F. and Fauvel, T. and Geoffroy, C.},
  title   = {{Treatment Effects of Cholinesterase Inhibitors in Alzheimer’s Disease: a Causal Machine Learning Approach}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.02.11.26346078},
  url     = {https://doi.org/10.64898/2026.02.11.26346078}
}

@article{zhao2026-758b6681,
  author  = {Zhao, Y. and Marder, K. and Wang, Y.},
  title   = {{Integrative Multimodal Subtyping, Risk of Incident Mild Cognitive Impairment, and Differential Cardiometabolic Treatment Effects: A Prospective Cohort Study in the All of Us Research Program}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.02.10.26345240},
  url     = {https://doi.org/10.64898/2026.02.10.26345240}
}

@article{green2026-93f370c9,
  author  = {Green, J. W. and Fonseca, L. M. and Beeri, M. S. and Simon, S. S. and Parrott, J. S. and Ljubic, B. and Schulewski, M. and Tafuto, B. and others},
  title   = {{Concurrent Gabapentin and Dihydropyridine Calcium Channel Blocker Use and Risk of Incident Dementia: An Active-Comparator Cohort Study}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.02.06.26345763},
  url     = {https://doi.org/10.64898/2026.02.06.26345763}
}

@article{saumur2026-69c75fbc,
  author  = {Saumur, T. M. and Ashraf, H. and Mathers, K. E. and Wagner, B. L.},
  title   = {{Pharmacotherapy for Alzheimer’s Disease and Dementias in Long-Term Care: A Real-World EHR Study}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.01.16.25342403},
  url     = {https://doi.org/10.64898/2026.01.16.25342403}
}

@article{weckstein2026-20b0989e,
  author  = {Weckstein, A. R. and Carr, S. and Wang, P. and Krüger, N. and Danaei, G. and Schneeweiss, S. and Desai, R. J.},
  title   = {{Lithium therapy and delayed progression of Alzheimer’s disease and related dementias in patients with bipolar disorder and mild neurocognitive disorders}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.01.12.26343472},
  url     = {https://doi.org/10.64898/2026.01.12.26343472}
}

@article{sen2025-31859e76,
  author  = {Şen, S. E.},
  title   = {{Budget Impact Analysis of Disease-Modifying Therapies for Alzheimer’s Disease in Ireland: A Model-Based Analysis}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.64898/2025.12.30.25343198},
  url     = {https://doi.org/10.64898/2025.12.30.25343198}
}

@article{adaszewski2025-8771179b,
  author  = {Adaszewski, S. and Schindler, T.},
  title   = {{Large Language Model-Driven Prioritization of Alzheimer’s Disease Drug Targets Across Multidimensional Criteria}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.64898/2025.12.28.25343106},
  url     = {https://doi.org/10.64898/2025.12.28.25343106}
}

@article{matev2025-d7d29632,
  author  = {Matev, V. and Rothenberg, M. and Donath, J. and Cukaci, C. and Klöbl, M. and Al Barede, K. and Stöhrmann, P. and Dörl, G. and others},
  title   = {{The effects of vortioxetine versus placebo on cognitive functioning in mild cognitive impairment: a placebo-controlled, randomized, double-blind study}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.64898/2025.12.10.25341977},
  url     = {https://doi.org/10.64898/2025.12.10.25341977}
}

@article{curd2025-b62fc105,
  author  = {Curd, B. C. and Zubrick, C. and Cliatt Brown, C. J. and Sorweid, M. K. and Dehoney, S. B. and Anzai, Y. and Minoshima, S. and Parks, A. L. and others},
  title   = {{Real-world experience with lecanemab therapy for Alzheimer’s disease in the Intermountain West}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.1101/2025.09.30.25337002},
  url     = {https://doi.org/10.1101/2025.09.30.25337002}
}

@article{jaeger2025-377d6a5b,
  author  = {Jaeger, J. and Staats, K. A. and Barnum, S. and Pope, P. and Kingery, L. and Buitendyk, M. and Cohen, S. and Tansey, M. G. and others},
  title   = {{XPro1595, a Selective Soluble TNF Neutralizer, in Early Alzheimer’s Disease with Inflammation (ADi): Results from the Phase 2 MINDFuL Trial}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.1101/2025.09.24.25336496},
  url     = {https://doi.org/10.1101/2025.09.24.25336496}
}

@article{banerjee2013-23438937,
  author  = {Banerjee, Sube and Hellier, Jennifer M. and Romeo, Renée and Dewey, Michael E. and Knapp, Martin Richard John and Ballard, Clive G. and Baldwin, R and Bentham, Peter and others},
  title   = {{Study of the use of antidepressants for depression in dementia: the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine}},
  journal = {Health Technology Assessment},
  year    = {2013},
  doi     = {10.3310/hta17070},
  pmid    = {23438937},
  url     = {https://doi.org/10.3310/hta17070}
}

@article{loveman2006-16409879,
  author  = {Loveman, Emma and Green, C and Kirby, J and Takeda, Andrea and Picot, Joanna and Payne, Liz and Clegg, Andrew Paul},
  title   = {{The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease}},
  journal = {Health Technology Assessment},
  year    = {2006},
  doi     = {10.3310/hta10010},
  pmid    = {16409879},
  url     = {https://doi.org/10.3310/hta10010}
}