% alzhub.org topic: Disease mechanisms in lab and animal studies
% Source: https://alzhub.org/topic/cognitive-impairment
% 1352 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{abdelhaleem2026-40435316,
  author  = {Abdel-Haleem, Alyaa M and Casavant, Ellen and Toth, Balazs and Teng, Edmond and Monteiro, Cecilia and Pandya, Nikhil J and Glock, Caspar and Hoogenraad, Casper C and others},
  title   = {{CSF proteomics of semorinemab Alzheimer's disease trials identifies cell-type specific signatures}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awaf200},
  pmid    = {40435316},
  url     = {https://doi.org/10.1093/brain/awaf200}
}

@article{tolosa2014-24532007,
  author  = {TOLOSA, EDUARDO S. and Litvan, Irene and Höglinger, Günter U. and Burn, David John and Lees, Andrew John and de Andrés, Maria Velasco and Gómez‐Carrillo, Belén and León, Teresa and others},
  title   = {{A phase 2 trial of the GSK‐3 inhibitor tideglusib in progressive supranuclear palsy}},
  journal = {Movement Disorders},
  year    = {2014},
  doi     = {10.1002/mds.25824},
  pmid    = {24532007},
  url     = {https://doi.org/10.1002/mds.25824}
}

@article{wang2025-40109019,
  author  = {Wang, Lisha and Sooram, Banesh and Kumar, Rajnish and Schedin-Weiss, Sophia and Tjernberg, Lars O and Winblad, Bengt},
  title   = {{Tau degradation in Alzheimer's disease: Mechanisms and therapeutic opportunities}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70048},
  pmid    = {40109019},
  url     = {https://doi.org/10.1002/alz.70048}
}

@article{castelloguillen2026-8eff1361,
  author  = {Castello-Guillen, A. and Garrido-Reig, M. and Caplliure-Llopis, J. and Vega-Bello, M. J. and Almela, C. and de la Rubia Ortí, J. E.},
  title   = {{Efficacy of Curcumin in Neurodegenerative Diseases: From Pharmacokinetic Barriers to Advanced Delivery Systems}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2026},
  doi     = {10.20944/preprints202608.1026.v1},
  url     = {https://doi.org/10.20944/preprints202608.1026.v1}
}

@article{yan2024-38048087,
  author  = {Yan, S. and Jiang, C. and Janzen, A. and Barber, T. R. and Seger, A. and Sommerauer, M. and Davis, J. J. and Marek, K. and others},
  title   = {{Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease}},
  journal = {JAMA neurology},
  year    = {2024},
  doi     = {10.1001/jamaneurol.2023.4398},
  pmid    = {38048087},
  url     = {https://doi.org/10.1001/jamaneurol.2023.4398}
}

@article{shulman2013-24067533,
  author  = {Shulman, Joshua M and Imboywa, Selina H. and Γιαγτζόγλου, Νικόλαος and Powers, Martin P. and Hu, Yanhui and Devenport, Danelle and Chipendo, Portia I. and Chibnik, Lori Beth and others},
  title   = {{Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms}},
  journal = {Human Molecular Genetics},
  year    = {2013},
  doi     = {10.1093/hmg/ddt478},
  pmid    = {24067533},
  url     = {https://doi.org/10.1093/hmg/ddt478}
}

@article{baddeley2015-25320049,
  author  = {Baddeley, T. C. and McCaffrey, J. and Storey, J. M. and Cheung, J. K. and Melis, V. and Horsley, D. and Harrington, C. R. and Wischik, C. M.},
  title   = {{Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer's disease}},
  journal = {The Journal of pharmacology and experimental therapeutics},
  year    = {2015},
  doi     = {10.1124/jpet.114.219352},
  pmid    = {25320049},
  url     = {https://doi.org/10.1124/jpet.114.219352}
}

@article{jeremic2021-34687956,
  author  = {Jeremic, D. and Jiménez-Díaz, L. and Navarro-López, J. D.},
  title   = {{Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: a systematic review}},
  journal = {Ageing research reviews},
  year    = {2021},
  doi     = {10.1016/j.arr.2021.101496},
  pmid    = {34687956},
  url     = {https://doi.org/10.1016/j.arr.2021.101496}
}

@article{serranopozo2010-20360050,
  author  = {Serrano-Pozo, A. and William, C. M. and Ferrer, I. and Uro-Coste, E. and Delisle, M. B. and Maurage, C. A. and Hock, C. and Nitsch, R. M. and others},
  title   = {{Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology}},
  journal = {Brain : a journal of neurology},
  year    = {2010},
  doi     = {10.1093/brain/awq056},
  pmid    = {20360050},
  url     = {https://doi.org/10.1093/brain/awq056}
}

@article{estellergauxax2026-42255968,
  author  = {Esteller-Gauxax, Diana and Guillén, Núria and Falgàs, Neus and Bosch, Beatriz and Tort-Merino, Adrià and Borrego-Écija, Sergi and Puey, Roger and Ruiz-Garcia, Raquel and others},
  title   = {{Atrophy signature for alpha-synuclein copathology in Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2026},
  doi     = {10.1002/dad2.70347},
  pmid    = {42255968},
  url     = {https://doi.org/10.1002/dad2.70347}
}

@article{bhembre2023-37821232,
  author  = {Bhembre, Nishita and Bonthron, Calum and Opazo, Patricio},
  title   = {{Synaptic Compensatory Plasticity in Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2023},
  doi     = {10.1523/jneurosci.0379-23.2023},
  pmid    = {37821232},
  url     = {https://doi.org/10.1523/jneurosci.0379-23.2023}
}

@article{kepp2016-27327400,
  author  = {Kepp, K. P.},
  title   = {{Alzheimer's disease due to loss of function: A new synthesis of the available data}},
  journal = {Progress in neurobiology},
  year    = {2016},
  doi     = {10.1016/j.pneurobio.2016.06.004},
  pmid    = {27327400},
  url     = {https://doi.org/10.1016/j.pneurobio.2016.06.004}
}

@article{may2015-25609634,
  author  = {May, P. C. and Willis, B. A. and Lowe, S. L. and Dean, R. A. and Monk, S. A. and Cocke, P. J. and Audia, J. E. and Boggs, L. N. and others},
  title   = {{The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.4129-14.2015},
  pmid    = {25609634},
  url     = {https://doi.org/10.1523/jneurosci.4129-14.2015}
}

@article{vogel2020-32457389,
  author  = {Vogel, J. W. and Iturria-Medina, Y. and Strandberg, O. T. and Smith, R. and Levitis, E. and Evans, A. C. and Hansson, O. and {Alzheimer’s Disease Neuroimaging Initiative} and others},
  title   = {{Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-15701-2},
  pmid    = {32457389},
  url     = {https://doi.org/10.1038/s41467-020-15701-2}
}

@article{tome2023-37777806,
  author  = {Tomé, Sandra O and Tsaka, Grigoria and Ronisz, Alicja and Ospitalieri, Simona and Gawor, Klara and Gomes, Luis Aragão and Otto, Markus and von Arnim, Christine A F and others},
  title   = {{TDP-43 pathology is associated with increased tau burdens and seeding}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00653-0},
  pmid    = {37777806},
  url     = {https://doi.org/10.1186/s13024-023-00653-0}
}

@article{zhang2020-32050258,
  author  = {Zhang, W. and Tarutani, A. and Newell, K. L. and Murzin, A. G. and Matsubara, T. and Falcon, B. and Vidal, R. and Garringer, H. J. and others},
  title   = {{Novel tau filament fold in corticobasal degeneration}},
  journal = {Nature},
  year    = {2020},
  doi     = {10.1038/s41586-020-2043-0},
  pmid    = {32050258},
  url     = {https://doi.org/10.1038/s41586-020-2043-0}
}

@article{maeda2007-17928437,
  author  = {Maeda, J. and Ji, B. and Irie, T. and Tomiyama, T. and Maruyama, M. and Okauchi, T. and Staufenbiel, M. and Iwata, N. and others},
  title   = {{Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.0673-07.2007},
  pmid    = {17928437},
  url     = {https://doi.org/10.1523/jneurosci.0673-07.2007}
}

@article{garcaalloza2007-17472706,
  author  = {Garcı́a-Alloza, Mónica and Borrelli, Laura A. and Rozkalne, Anete and Hyman, Bradley T. and Bacskai, Brian J.},
  title   = {{Curcumin labels amyloid pathology in vivo , disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model}},
  journal = {Journal of Neurochemistry},
  year    = {2007},
  doi     = {10.1111/j.1471-4159.2007.04613.x},
  pmid    = {17472706},
  url     = {https://doi.org/10.1111/j.1471-4159.2007.04613.x}
}

@article{irwin2024-38278991,
  author  = {Irwin, K. E. and Jasin, P. and Braunstein, K. E. and Sinha, I. R. and Garret, M. A. and Bowden, K. D. and Chang, K. and Troncoso, J. C. and others},
  title   = {{A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD}},
  journal = {Nature medicine},
  year    = {2024},
  doi     = {10.1038/s41591-023-02788-5},
  pmid    = {38278991},
  url     = {https://doi.org/10.1038/s41591-023-02788-5}
}

@article{phillips2024-38000775,
  author  = {Phillips, Kimberley A and Lopez, Matthew and Bartling-John, Evelyn and Meredith, Reagan and Buteau, Anna and Alvarez, Addaline and Ross, Corinna N},
  title   = {{Serum biomarkers associated with aging and neurodegeneration in common marmosets (Callithrix jacchus)}},
  journal = {Neuroscience letters},
  year    = {2024},
  doi     = {10.1016/j.neulet.2023.137569},
  pmid    = {38000775},
  url     = {https://doi.org/10.1016/j.neulet.2023.137569}
}

@article{stuendl2016-26647156,
  author  = {Stuendl, A. and Kunadt, M. and Kruse, N. and Bartels, C. and Moebius, W. and Danzer, K. M. and Mollenhauer, B. and Schneider, A.},
  title   = {{Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies}},
  journal = {Brain : a journal of neurology},
  year    = {2016},
  doi     = {10.1093/brain/awv346},
  pmid    = {26647156},
  url     = {https://doi.org/10.1093/brain/awv346}
}

@article{tomiyama2008-18300294,
  author  = {Tomiyama, T. and Nagata, T. and Shimada, H. and Teraoka, R. and Fukushima, A. and Kanemitsu, H. and Takuma, H. and Kuwano, R. and others},
  title   = {{A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia}},
  journal = {Annals of neurology},
  year    = {2008},
  doi     = {10.1002/ana.21321},
  pmid    = {18300294},
  url     = {https://doi.org/10.1002/ana.21321}
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@article{mackenzie2006-17021754,
  author  = {Mackenzie, I. R. and Baborie, A. and Pickering-Brown, S. and Du Plessis, D. and Jaros, E. and Perry, R. H. and Neary, D. and Snowden, J. S. and others},
  title   = {{Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype}},
  journal = {Acta neuropathologica},
  year    = {2006},
  doi     = {10.1007/s00401-006-0138-9},
  pmid    = {17021754},
  url     = {https://doi.org/10.1007/s00401-006-0138-9}
}

@article{dunot2026-42237024,
  author  = {Dunot, Jade and Gandin, Carine and Truchi, Marin and Pirro, Giulia and Moreno, Sébastien and Launay, Agathe and Azoulay, Benjamin and Landra, Hugo and others},
  title   = {{AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction}},
  journal = {Acta neuropathologica},
  year    = {2026},
  doi     = {10.1007/s00401-026-03033-2},
  pmid    = {42237024},
  url     = {https://doi.org/10.1007/s00401-026-03033-2}
}

@article{deruyter2023-37640753,
  author  = {de Ruyter, Frederique J Hart and Morrema, Tjado H J and den Haan, Jurre and Gase, Gina and Twisk, Jos W R and de Boer, Johannes F and Scheltens, Philip and Bouwman, Femke H and others},
  title   = {{α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies}},
  journal = {NPJ Parkinson's disease},
  year    = {2023},
  doi     = {10.1038/s41531-023-00570-5},
  pmid    = {37640753},
  url     = {https://doi.org/10.1038/s41531-023-00570-5}
}

@article{yuan2022-36450991,
  author  = {Yuan, P. and Zhang, M. and Tong, L. and Morse, T. M. and McDougal, R. A. and Ding, H. and Chan, D. and Cai, Y. and others},
  title   = {{PLD3 affects axonal spheroids and network defects in Alzheimer's disease}},
  journal = {Nature},
  year    = {2022},
  doi     = {10.1038/s41586-022-05491-6},
  pmid    = {36450991},
  url     = {https://doi.org/10.1038/s41586-022-05491-6}
}

@article{berdynski2022-36031890,
  author  = {Berdyński, Mariusz and Ludwiczak, Jan and Barczak, Anna and Barcikowska-Kotowicz, Maria and Kuźma-Kozakiewicz, Magdalena and Dunin-Horkawicz, Stanisław and Żekanowski, Cezary and Borzemska, Beata},
  title   = {{TREM2 Gene Compound Heterozygosity in Neurodegenerative Disorders}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220210},
  pmid    = {36031890},
  url     = {https://doi.org/10.3233/jad-220210}
}

@article{panza2016-27429978,
  author  = {Panza, F. and Solfrizzi, V. and Seripa, D. and Imbimbo, B. P. and Lozupone, M. and Santamato, A. and Zecca, C. and Barulli, M. R. and others},
  title   = {{Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease}},
  journal = {BioMed research international},
  year    = {2016},
  doi     = {10.1155/2016/3245935},
  pmid    = {27429978},
  url     = {https://doi.org/10.1155/2016/3245935}
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@article{pizzo2025-40773560,
  author  = {Pizzo, M. E. and Plowey, E. D. and Khoury, N. and Kwan, W. and Abettan, J. and DeVos, S. L. and Discenza, C. B. and Earr, T. and others},
  title   = {{Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA}},
  journal = {Science (New York, N.Y.)},
  year    = {2025},
  doi     = {10.1126/science.ads3204},
  pmid    = {40773560},
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@article{lee2022-35654956,
  author  = {Lee, J. H. and Yang, D. S. and Goulbourne, C. N. and Im, E. and Stavrides, P. and Pensalfini, A. and Chan, H. and Bouchet-Marquis, C. and others},
  title   = {{Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques}},
  journal = {Nature neuroscience},
  year    = {2022},
  doi     = {10.1038/s41593-022-01084-8},
  pmid    = {35654956},
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}

@article{leng2021-33432193,
  author  = {Leng, K. and Li, E. and Eser, R. and Piergies, A. and Sit, R. and Tan, M. and Neff, N. and Li, S. H. and others},
  title   = {{Molecular characterization of selectively vulnerable neurons in Alzheimer's disease}},
  journal = {Nature neuroscience},
  year    = {2021},
  doi     = {10.1038/s41593-020-00764-7},
  pmid    = {33432193},
  url     = {https://doi.org/10.1038/s41593-020-00764-7}
}

@article{delhaye2021-33414502,
  author  = {Delhaye, S. and Bardoni, B.},
  title   = {{Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders}},
  journal = {Molecular psychiatry},
  year    = {2021},
  doi     = {10.1038/s41380-020-00997-9},
  pmid    = {33414502},
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@article{xu2021-32366951,
  author  = {Xu, Y. and Du, S. and Marsh, J. A. and Horie, K. and Sato, C. and Ballabio, A. and Karch, C. M. and Holtzman, D. M. and others},
  title   = {{TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading}},
  journal = {Molecular psychiatry},
  year    = {2021},
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  pmid    = {32366951},
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@article{sorrentino2017-29211722,
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  title   = {{Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity}},
  journal = {Nature},
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@article{west2017-29181488,
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  title   = {{Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2017},
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  pmid    = {29181488},
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@article{jiang2025-40488453,
  author  = {Jiang, Shan and Srikanth, Malavika and Serpe, Rossana and Yavari, Shadi and Gaur, Pallavi and Collins, Galen Andrew and Soni, Rajesh and Menon, Vilas and others},
  title   = {{Early proteasome downregulation and dysfunction drive proteostasis failure in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2025},
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  pmid    = {40488453},
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@article{holec2025-41206373,
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@article{buck2025-41128923,
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  title   = {{LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies}},
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  title   = {{Direct evidence for dendritic spine compensation and regeneration in Alzheimer's disease models}},
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@article{gao2025-40990068,
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  title   = {{PINK1 deficiency permits the development of Lewy body dementia with coexisting Aβ pathology}},
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  title   = {{Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's disease}},
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@article{ondrejcak2025-40455293,
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  title   = {{Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region}},
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@article{lanedonovan2025-40469052,
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  title   = {{Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases}},
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  year    = {2025},
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@article{danis2025-40175345,
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  title   = {{Inhibition of tau neuronal internalization using anti-tau single domain antibodies}},
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@article{tang2025-39988732,
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  title   = {{Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration}},
  journal = {Autophagy},
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@article{khawaja2025-39910244,
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  title   = {{Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging}},
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@article{perdok2024-39613768,
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  title   = {{Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits}},
  journal = {Nature communications},
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@article{aggidis2024-39360630,
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  title   = {{A novel peptide-based tau aggregation inhibitor as a potential therapeutic for Alzheimer's disease and other tauopathies}},
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@article{kunach2024-39353896,
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  title   = {{Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240}},
  journal = {Nature communications},
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@article{dean2024-39032157,
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  title   = {{Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants}},
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@article{robinson2024-38896345,
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  title   = {{Annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative disease proteinopathies}},
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@article{latifhernandez2024-38779814,
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  title   = {{A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model}},
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@article{wongsodirdjo2024-38585667,
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@article{yang2025-40650049,
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  title   = {{Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease}},
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@article{calvorodriguez2024-38238819,
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  title   = {{Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype}},
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@article{chen2023-37674720,
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  title   = {{HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent}},
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  url     = {https://doi.org/10.1016/j.nbas.2025.100136}
}

@article{pereyra2025-40198223,
  author  = {Pereyra, Guadalupe and Mateo, María Inés and Miaja, Pablo and Martin-Bermejo, María Jesús and Martinez-Baños, Marcos and Klaassen, Remco and Gruart, Agnès and Rueda-Carrasco, Javier and others},
  title   = {{SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment}},
  journal = {Cell reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.115535},
  pmid    = {40198223},
  url     = {https://doi.org/10.1016/j.celrep.2025.115535}
}

@article{li2025-39991952,
  author  = {Li, Dexiang and Wang, Gaoyang and Sun, Maozhong and Qu, Aihua and Xu, Chuanlai and Wang, Qing and Hao, Changlong and Kuang, Hua},
  title   = {{Chiral Bimetallic Pt@Au Octapods with Spiral Four-Petal Flower-Like Symmetric Configuration as Sensitive SERS Probes}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2025},
  doi     = {10.1002/anie.202501894},
  pmid    = {39991952},
  url     = {https://doi.org/10.1002/anie.202501894}
}

@article{fang2025-39907042,
  author  = {Fang, Kevin and Pishva, Ehsan and Piers, Thomas and Scholpp, Steffen},
  title   = {{Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease}},
  journal = {Journal of cell science},
  year    = {2025},
  doi     = {10.1242/jcs.263526},
  pmid    = {39907042},
  url     = {https://doi.org/10.1242/jcs.263526}
}

@article{balducci2025-39871396,
  author  = {Balducci, Claudia and Orsini, Franca and Cerovic, Milica and Beeg, Marten and Rocutto, Beatrice and Dacomo, Letizia and Masone, Antonio and Busani, Eleonora and others},
  title   = {{Tau oligomers impair memory and synaptic plasticity through the cellular prion protein}},
  journal = {Acta neuropathologica communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-01930-3},
  pmid    = {39871396},
  url     = {https://doi.org/10.1186/s40478-025-01930-3}
}

@article{bhattacharya2025-39815655,
  author  = {Bhattacharya, Radha Shree and Singh, Raghuraj and Panghal, Archna and Thakur, Ashima and Singh, Lachhman and Verma, Rahul Kumar and Singh, Charan and Goyal, Manoj and others},
  title   = {{Multi-Targeting Phytochemicals for Alzheimer's Disease}},
  journal = {Phytotherapy research : PTR},
  year    = {2025},
  doi     = {10.1002/ptr.8435},
  pmid    = {39815655},
  url     = {https://doi.org/10.1002/ptr.8435}
}

@article{ma2025-39714451,
  author  = {Ma, Mengmeng and Wang, Jing and Guo, Kaiming and Zhong, Wenbin and Cheng, Yu and Lin, Li and Zhao, Yanli},
  title   = {{A Self-Reinforced "Microglia Energy Modulator" for Synergistic Amyloid-β Clearance in Alzheimer's Disease Model}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2025},
  doi     = {10.1002/anie.202420547},
  pmid    = {39714451},
  url     = {https://doi.org/10.1002/anie.202420547}
}

@article{park2025-39744681,
  author  = {Park, Moonsu and Ryu, Hongji and Heo, Suyeon and Kim, Boyoung and Park, Junhang and Lim, Key-Hwan and Han, Sang-Bae and Park, Hanseul},
  title   = {{Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model}},
  journal = {Theranostics},
  year    = {2025},
  doi     = {10.7150/thno.103455},
  pmid    = {39744681},
  url     = {https://doi.org/10.7150/thno.103455}
}

@article{chiu2025-39743215,
  author  = {Chiu, Yuanpu and Xia, Shangzhou and Qiao, Haowen and Zhao, Zhen},
  title   = {{Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia: New Insights from Single-Cell and Spatial Transcriptomics}},
  journal = {The American journal of pathology},
  year    = {2025},
  doi     = {10.1016/j.ajpath.2024.11.006},
  pmid    = {39743215},
  url     = {https://doi.org/10.1016/j.ajpath.2024.11.006}
}

@article{endicott2024-39687864,
  author  = {Endicott, S Joseph},
  title   = {{Chaperone-mediated autophagy as a modulator of aging and longevity}},
  journal = {Frontiers in aging},
  year    = {2024},
  doi     = {10.3389/fragi.2024.1509400},
  pmid    = {39687864},
  url     = {https://doi.org/10.3389/fragi.2024.1509400}
}

@article{collingridge2025-39615648,
  author  = {Collingridge, Graham L},
  title   = {{Long-term potentiation in the hippocampus: From magnesium to memory}},
  journal = {Neuroscience},
  year    = {2025},
  doi     = {10.1016/j.neuroscience.2024.11.069},
  pmid    = {39615648},
  url     = {https://doi.org/10.1016/j.neuroscience.2024.11.069}
}

@article{jang2024-39500576,
  author  = {Jang, Elliot and Hoxha, Kevt'her and Mozier, Damian and Insana, Abigail and Farber, Ethan and Changolkar, Lakshmi and Zhang, Bin and Chio, Tak-Ian and others},
  title   = {{Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2024},
  doi     = {10.1523/jneurosci.0877-24.2024},
  pmid    = {39500576},
  url     = {https://doi.org/10.1523/jneurosci.0877-24.2024}
}

@article{tangavelou2024-39596399,
  author  = {Tangavelou, Karthikeyan and Bhaskar, Kiran},
  title   = {{The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms252212335},
  pmid    = {39596399},
  url     = {https://doi.org/10.3390/ijms252212335}
}

@article{guo2025-39532095,
  author  = {Guo, Jing L and Braun, Dylan and Fitzgerald, Gabriel A and Hsieh, Yun-Ting and Rougé, Lionel and Litvinchuk, Alexandra and Steffek, Micah and Propson, Nicholas E and others},
  title   = {{Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes}},
  journal = {Cell},
  year    = {2025},
  doi     = {10.1016/j.cell.2024.10.027},
  pmid    = {39532095},
  url     = {https://doi.org/10.1016/j.cell.2024.10.027}
}

@article{bang2024-39634029,
  author  = {Bang, Sookhee and Song, Jeong Kuen and Lee, Kwan Hee},
  title   = {{Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer's diseases}},
  journal = {IBRO neuroscience reports},
  year    = {2024},
  doi     = {10.1016/j.ibneur.2024.11.005},
  pmid    = {39634029},
  url     = {https://doi.org/10.1016/j.ibneur.2024.11.005}
}

@article{zhou2024-39613463,
  author  = {Zhou, Futao and Zhao, Yushi and Sun, Yangyan and Chen, Wanjiao},
  title   = {{Molecular Insights into Tau Pathology and its Therapeutic Strategies in Alzheimer's Disease}},
  journal = {Journal of integrative neuroscience},
  year    = {2024},
  doi     = {10.31083/j.jin2311197},
  pmid    = {39613463},
  url     = {https://doi.org/10.31083/j.jin2311197}
}

@article{conceicao2024-39525305,
  author  = {Conceição, Mariana and Di Filippo, Leonardo Delello and Duarte, Jonatas Lobato and Beserra, Fernando Pereira and Gremião, Maria Palmira Daflon and Chorilli, Marlus},
  title   = {{Repurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective}},
  journal = {Brain, behavior, \& immunity - health},
  year    = {2024},
  doi     = {10.1016/j.bbih.2024.100894},
  pmid    = {39525305},
  url     = {https://doi.org/10.1016/j.bbih.2024.100894}
}

@article{lu2025-39447490,
  author  = {Lu, Wenyan and Shue, Francis and Kurti, Aishe and Jeevaratnam, Suren and Macyczko, Jesse R and Roy, Bhaskar and Izhar, Taha and Wang, Ni and others},
  title   = {{Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2025},
  doi     = {10.1016/j.neurobiolaging.2024.10.005},
  pmid    = {39447490},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2024.10.005}
}

@article{chinnathambi2025-40973404,
  author  = {Chinnathambi, Subashchandrabose},
  title   = {{Tau proteotasis in Alzheimer's disease}},
  journal = {Advances in protein chemistry and structural biology},
  year    = {2025},
  doi     = {10.1016/bs.apcsb.2024.09.003},
  pmid    = {40973404},
  url     = {https://doi.org/10.1016/bs.apcsb.2024.09.003}
}

@article{shinohara2024-39370836,
  author  = {Shinohara, Moeko and Ono, Kenjiro},
  title   = {{[Anti-Amyloid Antibody Therapy for Alzheimer's Disease]}},
  journal = {Brain and nerve = Shinkei kenkyu no shinpo},
  year    = {2024},
  doi     = {10.11477/mf.1416202747},
  pmid    = {39370836},
  url     = {https://doi.org/10.11477/mf.1416202747}
}

@article{sinha2024-39404364,
  author  = {Sinha, Priyanka and Turchyna, Yuliia and Mitchell, Shane Patrick Clancy and Sadek, Michael and Armagan, Gokce and Perrin, Florian and Maesako, Masato and Berezovska, Oksana},
  title   = {{Glutamate Transporter 1 as a Novel Negative Regulator of Amyloid β}},
  journal = {Cells},
  year    = {2024},
  doi     = {10.3390/cells13191600},
  pmid    = {39404364},
  url     = {https://doi.org/10.3390/cells13191600}
}

@article{cao2024-39316084,
  author  = {Cao, Qiuchen and Yang, Shige and Wang, Xiaowei and Sun, Huaiqing and Chen, Weijie and Wang, Yuliang and Gao, Junying and Wu, Yanchi and others},
  title   = {{Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer's disease}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20240386},
  pmid    = {39316084},
  url     = {https://doi.org/10.1084/jem.20240386}
}

@article{paesmans2024-39381137,
  author  = {Paesmans, Ine and Van Kolen, Kristof and Vandermeeren, Marc and Shih, Pei-Yu and Wuyts, Dirk and Boone, Fleur and Sanchez, Sergio Garcia and Grauwen, Karolien and others},
  title   = {{NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology}},
  journal = {Frontiers in aging neuroscience},
  year    = {2024},
  doi     = {10.3389/fnagi.2024.1459134},
  pmid    = {39381137},
  url     = {https://doi.org/10.3389/fnagi.2024.1459134}
}

@article{prikhodko2024-39134419,
  author  = {Prikhodko, Olga and Freund, Ronald K and Sullivan, Emily and Kennedy, Matthew J and Dell'Acqua, Mark L},
  title   = {{Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2024},
  doi     = {10.1523/jneurosci.0675-24.2024},
  pmid    = {39134419},
  url     = {https://doi.org/10.1523/jneurosci.0675-24.2024}
}

@article{haseenap2024-39244567,
  author  = {Haseena P, A. and Basavaraju, Nimisha and Chandran, Mahesh and Jaleel, Abdul and Bennett, David A and Kommaddi, Reddy Peera},
  title   = {{Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01558-w},
  pmid    = {39244567},
  url     = {https://doi.org/10.1186/s13195-024-01558-w}
}

@article{xiang2024-39241780,
  author  = {Xiang, Jie and Tang, Jingrong and Kang, Fei and Ye, Jiajun and Cui, Yueying and Zhang, Zhentao and Wang, Jing and Wu, Shengxi and others},
  title   = {{Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson's and Alzheimer's disease co-pathology and behavior impairments}},
  journal = {Neuron},
  year    = {2024},
  doi     = {10.1016/j.neuron.2024.08.003},
  pmid    = {39241780},
  url     = {https://doi.org/10.1016/j.neuron.2024.08.003}
}

@article{miyazaki2024-39251226,
  author  = {Miyazaki, Takehiro and Higashi, Shinji and Arai, Tetsuaki},
  title   = {{[Disease-modifying Drugs for non-Alzheimer Dementias]}},
  journal = {Brain and nerve = Shinkei kenkyu no shinpo},
  year    = {2024},
  doi     = {10.11477/mf.1416202733},
  pmid    = {39251226},
  url     = {https://doi.org/10.11477/mf.1416202733}
}

@article{thapa2024-39216694,
  author  = {Thapa, Riya and Bhat, Asif Ahmad and Shahwan, Moyad and Ali, Haider and PadmaPriya, G and Bansal, Pooja and Rajotiya, Sumit and Barwal, Amit and others},
  title   = {{Proteostasis disruption and senescence in Alzheimer's disease pathways to neurodegeneration}},
  journal = {Brain research},
  year    = {2024},
  doi     = {10.1016/j.brainres.2024.149202},
  pmid    = {39216694},
  url     = {https://doi.org/10.1016/j.brainres.2024.149202}
}

@article{lin2024-39281281,
  author  = {Lin, Hongru and Zhang, Chen and Gao, Yehui and Zhou, Yi and Ma, Botian and Jiang, Jinyun and Long, Xue and Yimamu, Nuerziya and others},
  title   = {{HLH-30/TFEB modulates autophagy to improve proteostasis in Aβ transgenic Caenorhabditis elegans}},
  journal = {Frontiers in pharmacology},
  year    = {2024},
  doi     = {10.3389/fphar.2024.1433030},
  pmid    = {39281281},
  url     = {https://doi.org/10.3389/fphar.2024.1433030}
}

@article{yan2024-39136994,
  author  = {Yan, Kuo and Zhang, Chen and Kang, Jongkyun and Montenegro, Paola and Shen, Jie},
  title   = {{Cortical neurodegeneration caused by Psen1 mutations is independent of Aβ}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2024},
  doi     = {10.1073/pnas.2409343121},
  pmid    = {39136994},
  url     = {https://doi.org/10.1073/pnas.2409343121}
}

@article{chen2024-39137870,
  author  = {Chen, Junhua and Peng, Guoping and Sun, Binggui},
  title   = {{Alzheimer's disease and sleep disorders: A bidirectional relationship}},
  journal = {Neuroscience},
  year    = {2024},
  doi     = {10.1016/j.neuroscience.2024.08.008},
  pmid    = {39137870},
  url     = {https://doi.org/10.1016/j.neuroscience.2024.08.008}
}

@article{xie2024-39096284,
  author  = {Xie, Siqi and Liang, Yumei and Song, Yang and Li, Tingting and Jia, Jianping},
  title   = {{Repurposing Anidulafungin for Alzheimer's Disease via Fragment-Based Drug Discovery}},
  journal = {ACS chemical neuroscience},
  year    = {2024},
  doi     = {10.1021/acschemneuro.4c00150},
  pmid    = {39096284},
  url     = {https://doi.org/10.1021/acschemneuro.4c00150}
}

@article{shin2024-39085348,
  author  = {Shin, Kyung Chul and Moussa, Houda Yasmine Ali and Park, Yongsoo},
  title   = {{Cholesterol imbalance and neurotransmission defects in neurodegeneration}},
  journal = {Experimental \& molecular medicine},
  year    = {2024},
  doi     = {10.1038/s12276-024-01273-4},
  pmid    = {39085348},
  url     = {https://doi.org/10.1038/s12276-024-01273-4}
}

@article{ye2024-38869076,
  author  = {Ye, Yu and Jia, Penghui and Miao, Jiafan and Wang, Yicheng and Li, Zibo and Lin, Yuxin and He, Miao and Liu, Shurui and others},
  title   = {{CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity}},
  journal = {Autophagy},
  year    = {2024},
  doi     = {10.1080/15548627.2024.2367183},
  pmid    = {38869076},
  url     = {https://doi.org/10.1080/15548627.2024.2367183}
}

@article{waldherr2024-39060347,
  author  = {Waldherr, Sarah M and Han, Marina and Saxton, Aleen D and Vadset, Taylor A and McMillan, Pamela J and Wheeler, Jeanna M and Liachko, Nicole F and Kraemer, Brian C},
  title   = {{Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy}},
  journal = {Communications biology},
  year    = {2024},
  doi     = {10.1038/s42003-024-06570-2},
  pmid    = {39060347},
  url     = {https://doi.org/10.1038/s42003-024-06570-2}
}

@article{gaikwad2024-38959324,
  author  = {Gaikwad, Sagar and Puangmalai, Nicha and Sonawane, Minal and Montalbano, Mauro and Price, Rachel and Iyer, Malini S and Ray, Anamika and Moreno, Sandra and others},
  title   = {{Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adj5958},
  pmid    = {38959324},
  url     = {https://doi.org/10.1126/scitranslmed.adj5958}
}

@article{bravo2024-38915105,
  author  = {Bravo, Celeste Parra and Krukowski, Karen and Barker, Sarah and Wang, Chao and Li, Yaqiao and Fan, Li and Vázquez-Rosa, Edwin and Shin, Min-Kyoo and others},
  title   = {{Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-024-00733-9},
  pmid    = {38915105},
  url     = {https://doi.org/10.1186/s13024-024-00733-9}
}

@article{pawar2025-40395755,
  author  = {Pawar, Shreya and Rauf, Mohd Ahmar and Abdelhady, Hosam and Iyer, Arun K},
  title   = {{Tau-targeting nanoparticles for treatment of Alzheimer's disease}},
  journal = {Exploration (Beijing, China)},
  year    = {2025},
  doi     = {10.1002/exp.20230137},
  pmid    = {40395755},
  url     = {https://doi.org/10.1002/exp.20230137}
}

@article{ferrari2024-38865459,
  author  = {Ferrari, Luca and Bauer, Bernd and Qiu, Yue and Schuschnig, Martina and Klotz, Sigrid and Anrather, Dorothea and Juretschke, Thomas and Beli, Petra and others},
  title   = {{Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion}},
  journal = {Science advances},
  year    = {2024},
  doi     = {10.1126/sciadv.adm8449},
  pmid    = {38865459},
  url     = {https://doi.org/10.1126/sciadv.adm8449}
}

@article{hashim2024-38789405,
  author  = {Hashim, Khairun Nisa Binti and Matsuba, Yukio and Takahashi, Mika and Kamano, Naoko and Tooyama, Ikuo and Saido, Takaomi C and Hashimoto, Shoko},
  title   = {{Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice}},
  journal = {FEBS letters},
  year    = {2024},
  doi     = {10.1002/1873-3468.14895},
  pmid    = {38789405},
  url     = {https://doi.org/10.1002/1873-3468.14895}
}

@article{weber2024-38763001,
  author  = {Weber, Patrick and Bojarová, Pavla and Brouzdová, Jitka and Křen, Vladimír and Kulik, Natalia and Stütz, Arnold E and Thonhofer, Martin and Wrodnigg, Tanja M},
  title   = {{Diaminocyclopentane - l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase}},
  journal = {Bioorganic chemistry},
  year    = {2024},
  doi     = {10.1016/j.bioorg.2024.107452},
  pmid    = {38763001},
  url     = {https://doi.org/10.1016/j.bioorg.2024.107452}
}

@article{zeng2024-38719948,
  author  = {Zeng, Juan and Hu, Xian-Feng and Sun, Dong-Sheng and Hong, Xiao-Yue and Ma, Jun-Zheng and Feng, Qiong},
  title   = {{Alzheimer-like behavior and synaptic dysfunction in 3 × Tg-AD mice are reversed with calcineurin inhibition}},
  journal = {Experimental brain research},
  year    = {2024},
  doi     = {10.1007/s00221-024-06841-8},
  pmid    = {38719948},
  url     = {https://doi.org/10.1007/s00221-024-06841-8}
}

@article{kinger2024-38797543,
  author  = {Kinger, Sumit and Jagtap, Yuvraj Anandrao and Kumar, Prashant and Choudhary, Akash and Prasad, Amit and Prajapati, Vijay Kumar and Kumar, Amit and Mehta, Gunjan and others},
  title   = {{Proteostasis in neurodegenerative diseases}},
  journal = {Advances in clinical chemistry},
  year    = {2024},
  doi     = {10.1016/bs.acc.2024.04.002},
  pmid    = {38797543},
  url     = {https://doi.org/10.1016/bs.acc.2024.04.002}
}

@article{wang2024-38916730,
  author  = {Wang, Zijian and Pan, Jun-Ping and Geng, Jiayuan and Lv, Shijie and Chen, Guisi and Fang, Nian and Zhang, Zheng and Li, Junliang and others},
  title   = {{Nogo-A Drives Alzheimer's Disease Progression by Inducing Tauopathy Vulnerability}},
  journal = {Aging and disease},
  year    = {2024},
  doi     = {10.14336/ad.2024.0053},
  pmid    = {38916730},
  url     = {https://doi.org/10.14336/ad.2024.0053}
}

@article{dasilva2024-38615035,
  author  = {da Silva, Marina I Oliveira and Santejo, Miguel and Babcock, Isaac W and Magalhães, Ana and Minamide, Laurie S and Won, Seok-Joon and Castillo, Erika and Gerhardt, Ellen and others},
  title   = {{α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway}},
  journal = {Cell death \& disease},
  year    = {2024},
  doi     = {10.1038/s41419-024-06630-9},
  pmid    = {38615035},
  url     = {https://doi.org/10.1038/s41419-024-06630-9}
}

@article{panwar2024-38570333,
  author  = {Panwar, Surbhi and Uniyal, Prerna and Kukreti, Neelima and Hashmi, Afreen and Verma, Shivani and Arya, Aanchal and Joshi, Gaurav},
  title   = {{Role of autophagy and proteostasis in neurodegenerative diseases: Exploring the therapeutic interventions}},
  journal = {Chemical biology \& drug design},
  year    = {2024},
  doi     = {10.1111/cbdd.14515},
  pmid    = {38570333},
  url     = {https://doi.org/10.1111/cbdd.14515}
}

@article{zhang2024-38513667,
  author  = {Zhang, Denghong and Zhang, Wei and Ming, Chen and Gao, Xuheng and Yuan, Huilong and Lin, Xiaojie and Mao, Xinru and Wang, Chunping and others},
  title   = {{P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy}},
  journal = {Neuron},
  year    = {2024},
  doi     = {10.1016/j.neuron.2024.02.017},
  pmid    = {38513667},
  url     = {https://doi.org/10.1016/j.neuron.2024.02.017}
}

@article{nagayama2024-38508957,
  author  = {Nagayama, Takeru and Yagishita, Sosuke and Shibata, Megumi and Furuno, Akiko and Saito, Takashi and Saido, Takaomi C and Wakatsuki, Shuji and Araki, Toshiyuki},
  title   = {{Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation}},
  journal = {Neuroscience research},
  year    = {2024},
  doi     = {10.1016/j.neures.2024.03.003},
  pmid    = {38508957},
  url     = {https://doi.org/10.1016/j.neures.2024.03.003}
}

@article{smith2024-38618323,
  author  = {Smith, Blake and Ownby, Raymond L},
  title   = {{Disease-Modifying Treatments and Their Future in Alzheimer's Disease Management}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.56105},
  pmid    = {38618323},
  url     = {https://doi.org/10.7759/cureus.56105}
}

@article{delgiudice2024-38508903,
  author  = {Del Giudice, Kirsys Patricia and Cosgaya, Marina and Zaro, Idoia and Ravasi, Valeria and Santacruz, Pilar and Painous, Celia and Fernández, Manel and Cámara, Ana and others},
  title   = {{Anti-alpha synuclein and anti-tau immunotherapies: Can a cocktail approach work?}},
  journal = {Parkinsonism \& related disorders},
  year    = {2024},
  doi     = {10.1016/j.parkreldis.2024.106080},
  pmid    = {38508903},
  url     = {https://doi.org/10.1016/j.parkreldis.2024.106080}
}

@article{ayala2024-38452814,
  author  = {Ayala, Ivan and Bahrami, Atousa and Pan, Yuting and Spencer, Callen and Flanagan, Margaret E and Mesulam, M-Marsel and Gefen, Tamar and Geula, Changiz},
  title   = {{Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy}},
  journal = {Neurochemistry international},
  year    = {2024},
  doi     = {10.1016/j.neuint.2024.105719},
  pmid    = {38452814},
  url     = {https://doi.org/10.1016/j.neuint.2024.105719}
}

@article{schuster2024-38429929,
  author  = {Schuster, Kristen H and Zalon, Annie J and DiFranco, Danielle M and Putka, Alexandra F and Stec, Nicholas R and Jarrah, Sabrina I and Naeem, Arsal and Haque, Zaid and others},
  title   = {{ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice}},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year    = {2024},
  doi     = {10.1016/j.ymthe.2024.02.033},
  pmid    = {38429929},
  url     = {https://doi.org/10.1016/j.ymthe.2024.02.033}
}

@article{mintoo2024-38174740,
  author  = {Mintoo, Mubashir and Rajagopalan, Vinodh and O'Bryan, John P},
  title   = {{Intersectin - many facets of a scaffold protein}},
  journal = {Biochemical Society transactions},
  year    = {2024},
  doi     = {10.1042/bst20211241},
  pmid    = {38174740},
  url     = {https://doi.org/10.1042/bst20211241}
}

@article{varlow2024-38458074,
  author  = {Varlow, Cassis and Mathis, Chester A and Vasdev, Neil},
  title   = {{In vitro evaluation of [3H]PI-2620 and structural derivatives in non-Alzheimer's tauopathies}},
  journal = {Nuclear medicine and biology},
  year    = {2024},
  doi     = {10.1016/j.nucmedbio.2024.108891},
  pmid    = {38458074},
  url     = {https://doi.org/10.1016/j.nucmedbio.2024.108891}
}

@article{feng2024-38229533,
  author  = {Feng, Yiyuan and Xu, Zhongyun and Jin, Hongfu and Chen, Yuanyuan and Fu, Chenglai and Zhang, Yu and Yin, Yafu and Wang, Hui and others},
  title   = {{Metformin ameliorates mitochondrial damage induced by C9orf72 poly(GR) via upregulating AKT phosphorylation}},
  journal = {Journal of cellular biochemistry},
  year    = {2024},
  doi     = {10.1002/jcb.30526},
  pmid    = {38229533},
  url     = {https://doi.org/10.1002/jcb.30526}
}

@article{shi2024-38255905,
  author  = {Shi, Huahua and Zhao, Yan},
  title   = {{Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25020831},
  pmid    = {38255905},
  url     = {https://doi.org/10.3390/ijms25020831}
}

@article{vejandla2024-38313929,
  author  = {Vejandla, Bhuvanasai and Savani, Sarah and Appalaneni, Rohith and Veeravalli, Rithik S and Gude, Sai Sravya},
  title   = {{Alzheimer's Disease: The Past, Present, and Future of a Globally Progressive Disease}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.51705},
  pmid    = {38313929},
  url     = {https://doi.org/10.7759/cureus.51705}
}

@article{suzuki2024-38945936,
  author  = {Suzuki, Naoyuki and Hatta, Takuya and Ito, Mana and Kusakabe, Ken-Ichi},
  title   = {{Anti-amyloid-β Antibodies and Anti-tau Therapies for Alzheimer's Disease: Recent Advances and Perspectives}},
  journal = {Chemical \& pharmaceutical bulletin},
  year    = {2024},
  doi     = {10.1248/cpb.c24-00069},
  pmid    = {38945936},
  url     = {https://doi.org/10.1248/cpb.c24-00069}
}

@article{horsley2024-38512662,
  author  = {Horsley, David and Rickard, Janet E and Vorley, Thomas and Leeper, Matilda F and Wischik, Claude M and Harrington, Charles R},
  title   = {{Assays for the Screening and Characterization of Tau Aggregation Inhibitors}},
  journal = {Methods in molecular biology (Clifton, N.J.)},
  year    = {2024},
  doi     = {10.1007/978-1-0716-3629-9_5},
  pmid    = {38512662},
  url     = {https://doi.org/10.1007/978-1-0716-3629-9_5}
}

@article{ryan2024-38101818,
  author  = {Ryan, Laura and Rubinsztein, David C},
  title   = {{The autophagy of stress granules}},
  journal = {FEBS letters},
  year    = {2024},
  doi     = {10.1002/1873-3468.14787},
  pmid    = {38101818},
  url     = {https://doi.org/10.1002/1873-3468.14787}
}

@article{litvinchuk2024-37995685,
  author  = {Litvinchuk, Alexandra and Suh, Jung H and Guo, Jing L and Lin, Karin and Davis, Sonnet S and Bien-Ly, Nga and Tycksen, Eric and Tabor, G Travis and others},
  title   = {{Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist}},
  journal = {Neuron},
  year    = {2024},
  doi     = {10.1016/j.neuron.2023.10.023},
  pmid    = {37995685},
  url     = {https://doi.org/10.1016/j.neuron.2023.10.023}
}

@article{li2024-38486986,
  author  = {Li, Yixian and Yang, Peng and Meng, Ran and Xu, Shuting and Zhou, Lingling and Qian, Kang and Wang, Pengzhen and Cheng, Yunlong and others},
  title   = {{Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis}},
  journal = {Acta pharmaceutica Sinica. B},
  year    = {2024},
  doi     = {10.1016/j.apsb.2023.10.009},
  pmid    = {38486986},
  url     = {https://doi.org/10.1016/j.apsb.2023.10.009}
}

@article{tome2024-37793659,
  author  = {Tomé, Sandra O and Gawor, Klara and Thal, Dietmar Rudolf},
  title   = {{LATE-NC in Alzheimer's disease: Molecular aspects and synergies}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2024},
  doi     = {10.1111/bpa.13213},
  pmid    = {37793659},
  url     = {https://doi.org/10.1111/bpa.13213}
}

@article{kepp2023-37183523,
  author  = {Kepp, K. P. and Robakis, N. K. and Høilund-Carlsen, P. F. and Sensi, S. L. and Vissel, B.},
  title   = {{The amyloid cascade hypothesis: an updated critical review}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awad159},
  pmid    = {37183523},
  url     = {https://doi.org/10.1093/brain/awad159}
}

@article{mariner2024-37749371,
  author  = {Mariner, Blaise L and Rodriguez, Antonio S and Heath, Olivia C and McCormick, Mark A},
  title   = {{Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors}},
  journal = {GeroScience},
  year    = {2024},
  doi     = {10.1007/s11357-023-00938-8},
  pmid    = {37749371},
  url     = {https://doi.org/10.1007/s11357-023-00938-8}
}

@article{peng2023-37600514,
  author  = {Peng, Y. and Jin, H. and Xue, Y. H. and Chen, Q. and Yao, S. Y. and Du, M. Q. and Liu, S.},
  title   = {{Current and future therapeutic strategies for Alzheimer's disease: an overview of drug development bottlenecks}},
  journal = {Frontiers in aging neuroscience},
  year    = {2023},
  doi     = {10.3389/fnagi.2023.1206572},
  pmid    = {37600514},
  url     = {https://doi.org/10.3389/fnagi.2023.1206572}
}

@article{kimura2024-37391389,
  author  = {Kimura, Taeko and Sato, Haruaki and Kano, Maria and Tatsumi, Lisa and Tomita, Taisuke},
  title   = {{Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers}},
  journal = {FEBS open bio},
  year    = {2024},
  doi     = {10.1002/2211-5463.13667},
  pmid    = {37391389},
  url     = {https://doi.org/10.1002/2211-5463.13667}
}

@article{zhao2023-37264159,
  author  = {Zhao, Y. and Zheng, Q. and Hong, Y. and Gao, Y. and Hu, J. and Lang, M. and Zhang, H. and Zhou, Y. and others},
  title   = {{β 2 -Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice}},
  journal = {Nature neuroscience},
  year    = {2023},
  doi     = {10.1038/s41593-023-01352-1},
  pmid    = {37264159},
  url     = {https://doi.org/10.1038/s41593-023-01352-1}
}

@article{iliyasu2023-37113145,
  author  = {Iliyasu, M. O. and Musa, S. A. and Oladele, S. B. and Iliya, A. I.},
  title   = {{Amyloid-beta aggregation implicates multiple pathways in Alzheimer's disease: Understanding the mechanisms}},
  journal = {Frontiers in neuroscience},
  year    = {2023},
  doi     = {10.3389/fnins.2023.1081938},
  pmid    = {37113145},
  url     = {https://doi.org/10.3389/fnins.2023.1081938}
}

@article{grimm2023-37823690,
  author  = {Grimm, H. P. and Schumacher, V. and Schäfer, M. and Imhof-Jung, S. and Freskgård, P. O. and Brady, K. and Hofmann, C. and Rüger, P. and others},
  title   = {{Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans}},
  journal = {mAbs},
  year    = {2023},
  doi     = {10.1080/19420862.2023.2261509},
  pmid    = {37823690},
  url     = {https://doi.org/10.1080/19420862.2023.2261509}
}

@article{soderberg2023-36253511,
  author  = {Söderberg, L. and Johannesson, M. and Nygren, P. and Laudon, H. and Eriksson, F. and Osswald, G. and Möller, C. and Lannfelt, L.},
  title   = {{Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2023},
  doi     = {10.1007/s13311-022-01308-6},
  pmid    = {36253511},
  url     = {https://doi.org/10.1007/s13311-022-01308-6}
}

@article{bagaria2022-36142879,
  author  = {Bagaria, J. and Bagyinszky, E. and An, S. S. A.},
  title   = {{Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms231810970},
  pmid    = {36142879},
  url     = {https://doi.org/10.3390/ijms231810970}
}

@article{park2022-36109806,
  author  = {Park, H. and Shin, J. and Kim, Y. and Saito, T. and Saido, T. C. and Kim, J.},
  title   = {{CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease}},
  journal = {Translational neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s40035-022-00314-0},
  pmid    = {36109806},
  url     = {https://doi.org/10.1186/s40035-022-00314-0}
}

@article{roda2022-35017413,
  author  = {Roda, A. R. and Serra-Mir, G. and Montoliu-Gaya, L. and Tiessler, L. and Villegas, S.},
  title   = {{Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease}},
  journal = {Neural regeneration research},
  year    = {2022},
  doi     = {10.4103/1673-5374.332127},
  pmid    = {35017413},
  url     = {https://doi.org/10.4103/1673-5374.332127}
}

@article{drummond2022-35418158,
  author  = {Drummond, E. and Kavanagh, T. and Pires, G. and Marta-Ariza, M. and Kanshin, E. and Nayak, S. and Faustin, A. and Berdah, V. and others},
  title   = {{The amyloid plaque proteome in early onset Alzheimer's disease and Down syndrome}},
  journal = {Acta neuropathologica communications},
  year    = {2022},
  doi     = {10.1186/s40478-022-01356-1},
  pmid    = {35418158},
  url     = {https://doi.org/10.1186/s40478-022-01356-1}
}

@article{song2022-35300725,
  author  = {Song, C. and Shi, J. and Zhang, P. and Zhang, Y. and Xu, J. and Zhao, L. and Zhang, R. and Wang, H. and others},
  title   = {{Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond}},
  journal = {Translational neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s40035-022-00292-3},
  pmid    = {35300725},
  url     = {https://doi.org/10.1186/s40035-022-00292-3}
}

@article{lamptey2022-35163773,
  author  = {Lamptey, R. N. L. and Chaulagain, B. and Trivedi, R. and Gothwal, A. and Layek, B. and Singh, J.},
  title   = {{A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23031851},
  pmid    = {35163773},
  url     = {https://doi.org/10.3390/ijms23031851}
}

@article{gao2022-35090576,
  author  = {Gao, L. and Zhang, Y. and Sterling, K. and Song, W.},
  title   = {{Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential}},
  journal = {Translational neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s40035-022-00279-0},
  pmid    = {35090576},
  url     = {https://doi.org/10.1186/s40035-022-00279-0}
}

@article{xie2022-34992270,
  author  = {Xie, C. and Zhuang, X. X. and Niu, Z. and Ai, R. and Lautrup, S. and Zheng, S. and Jiang, Y. and Han, R. and others},
  title   = {{Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow}},
  journal = {Nature biomedical engineering},
  year    = {2022},
  doi     = {10.1038/s41551-021-00819-5},
  pmid    = {34992270},
  url     = {https://doi.org/10.1038/s41551-021-00819-5}
}

@article{holm2022-35482908,
  author  = {Holm, A. and Hansen, S. N. and Klitgaard, H. and Kauppinen, S.},
  title   = {{Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases}},
  journal = {RNA biology},
  year    = {2022},
  doi     = {10.1080/15476286.2022.2066334},
  pmid    = {35482908},
  url     = {https://doi.org/10.1080/15476286.2022.2066334}
}

@article{meisl2021-34714685,
  author  = {Meisl, G. and Hidari, E. and Allinson, K. and Rittman, T. and DeVos, S. L. and Sanchez, J. S. and Xu, C. K. and Duff, K. E. and others},
  title   = {{In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease}},
  journal = {Science advances},
  year    = {2021},
  doi     = {10.1126/sciadv.abh1448},
  pmid    = {34714685},
  url     = {https://doi.org/10.1126/sciadv.abh1448}
}

@article{chung2021-34425874,
  author  = {Chung, D. C. and Roemer, S. and Petrucelli, L. and Dickson, D. W.},
  title   = {{Cellular and pathological heterogeneity of primary tauopathies}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00476-x},
  pmid    = {34425874},
  url     = {https://doi.org/10.1186/s13024-021-00476-x}
}

@article{chen2021-34337898,
  author  = {Chen, X. and Sun, G. and Tian, E. and Zhang, M. and Davtyan, H. and Beach, T. G. and Reiman, E. M. and Blurton-Jones, M. and others},
  title   = {{Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure}},
  journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
  year    = {2021},
  doi     = {10.1002/advs.202101462},
  pmid    = {34337898},
  url     = {https://doi.org/10.1002/advs.202101462}
}

@article{oblak2021-34366832,
  author  = {Oblak, A. L. and Lin, P. B. and Kotredes, K. P. and Pandey, R. S. and Garceau, D. and Williams, H. M. and Uyar, A. and O'Rourke, R. and others},
  title   = {{Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.713726},
  pmid    = {34366832},
  url     = {https://doi.org/10.3389/fnagi.2021.713726}
}

@article{xu2021-34291435,
  author  = {Xu, X. and Sun, Y. and Cen, X. and Shan, B. and Zhao, Q. and Xie, T. and Wang, Z. and Hou, T. and others},
  title   = {{Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model}},
  journal = {Protein \& cell},
  year    = {2021},
  doi     = {10.1007/s13238-021-00858-3},
  pmid    = {34291435},
  url     = {https://doi.org/10.1007/s13238-021-00858-3}
}

@article{tolar2021-34198582,
  author  = {Tolar, M. and Hey, J. and Power, A. and Abushakra, S.},
  title   = {{Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer's Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22126355},
  pmid    = {34198582},
  url     = {https://doi.org/10.3390/ijms22126355}
}

@article{xia2021-34090488,
  author  = {Xia, Y. and Prokop, S. and Giasson, B. I.},
  title   = {{"Don't Phos Over Tau": recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00460-5},
  pmid    = {34090488},
  url     = {https://doi.org/10.1186/s13024-021-00460-5}
}

@article{hung2021-34133918,
  author  = {Hung, C. and Tuck, E. and Stubbs, V. and van der Lee, S. J. and Aalfs, C. and van Spaendonk, R. and Scheltens, P. and Hardy, J. and others},
  title   = {{SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.109259},
  pmid    = {34133918},
  url     = {https://doi.org/10.1016/j.celrep.2021.109259}
}

@article{li2021-34016162,
  author  = {Li, D. and McIntosh, C. S. and Mastaglia, F. L. and Wilton, S. D. and Aung-Htut, M. T.},
  title   = {{Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies}},
  journal = {Translational neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s40035-021-00240-7},
  pmid    = {34016162},
  url     = {https://doi.org/10.1186/s40035-021-00240-7}
}

@article{cano2021-33926475,
  author  = {Cano, A. and Turowski, P. and Ettcheto, M. and Duskey, J. T. and Tosi, G. and Sánchez-López, E. and García, M. L. and Camins, A. and others},
  title   = {{Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges}},
  journal = {Journal of nanobiotechnology},
  year    = {2021},
  doi     = {10.1186/s12951-021-00864-x},
  pmid    = {33926475},
  url     = {https://doi.org/10.1186/s12951-021-00864-x}
}

@article{horie2021-33283854,
  author  = {Horie, K. and Barthélemy, N. R. and Sato, C. and Bateman, R. J.},
  title   = {{CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awaa373},
  pmid    = {33283854},
  url     = {https://doi.org/10.1093/brain/awaa373}
}

@article{beckers2021-33632058,
  author  = {Beckers, J. and Tharkeshwar, A. K. and Van Damme, P.},
  title   = {{C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels}},
  journal = {Autophagy},
  year    = {2021},
  doi     = {10.1080/15548627.2021.1872189},
  pmid    = {33632058},
  url     = {https://doi.org/10.1080/15548627.2021.1872189}
}

@article{dacunzo2021-33579698,
  author  = {D'Acunzo, P. and Pérez-González, R. and Kim, Y. and Hargash, T. and Miller, C. and Alldred, M. J. and Erdjument-Bromage, H. and Penikalapati, S. C. and others},
  title   = {{Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome}},
  journal = {Science advances},
  year    = {2021},
  doi     = {10.1126/sciadv.abe5085},
  pmid    = {33579698},
  url     = {https://doi.org/10.1126/sciadv.abe5085}
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@article{chen2021-33517893,
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  title   = {{Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase}},
  journal = {Bioorganic chemistry},
  year    = {2023},
  doi     = {10.1016/j.bioorg.2023.106819},
  pmid    = {37666109},
  url     = {https://doi.org/10.1016/j.bioorg.2023.106819}
}

@article{lavekar2023-37620502,
  author  = {Lavekar, Sailee S and Harkin, Jade and Hernandez, Melody and Gomes, Cátia and Patil, Shruti and Huang, Kang-Chieh and Puntambekar, Shweta S and Lamb, Bruce T and others},
  title   = {{Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2023},
  doi     = {10.1038/s41598-023-40382-4},
  pmid    = {37620502},
  url     = {https://doi.org/10.1038/s41598-023-40382-4}
}

@article{davies2023-37600228,
  author  = {Davies, Caitlin and Tulloch, Jane and Yip, Ellie and Currie, Lydia and Colom-Cadena, Marti and Wegmann, Susanne and Hyman, Bradley T and Wilkins, Lewis and others},
  title   = {{Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model}},
  journal = {Brain and neuroscience advances},
  year    = {2023},
  doi     = {10.1177/23982128231191046},
  pmid    = {37600228},
  url     = {https://doi.org/10.1177/23982128231191046}
}

@article{mehrabipour2023-37626864,
  author  = {Mehrabipour, Mehrnaz and Jasemi, Neda S Kazemein and Dvorsky, Radovan and Ahmadian, Mohammad R},
  title   = {{A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling}},
  journal = {Cells},
  year    = {2023},
  doi     = {10.3390/cells12162054},
  pmid    = {37626864},
  url     = {https://doi.org/10.3390/cells12162054}
}

@article{panza2023-37405389,
  author  = {Panza, Francesco and Dibello, Vittorio and Sardone, Rodolfo and Castellana, Fabio and Zupo, Roberta and Lampignano, Luisa and Bortone, Ilaria and Stallone, Roberta and others},
  title   = {{Clinical development of passive tau-based immunotherapeutics for treating primary and secondary tauopathies}},
  journal = {Expert opinion on investigational drugs},
  year    = {2023},
  doi     = {10.1080/13543784.2023.2233892},
  pmid    = {37405389},
  url     = {https://doi.org/10.1080/13543784.2023.2233892}
}

@article{mohle2023-37508364,
  author  = {Möhle, Luisa and Stefan, Katja and Bascuñana, Pablo and Brackhan, Mirjam and Brüning, Thomas and Eiriz, Ivan and El Menuawy, Ahmed and van Genderen, Sylvie and others},
  title   = {{ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer's Disease}},
  journal = {Biology},
  year    = {2023},
  doi     = {10.3390/biology12070932},
  pmid    = {37508364},
  url     = {https://doi.org/10.3390/biology12070932}
}

@article{shi2023-37330290,
  author  = {Shi, Yang and Ghetti, Bernardino and Goedert, Michel and Scheres, Sjors H W},
  title   = {{Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir}},
  journal = {Journal of molecular biology},
  year    = {2023},
  doi     = {10.1016/j.jmb.2023.168025},
  pmid    = {37330290},
  url     = {https://doi.org/10.1016/j.jmb.2023.168025}
}

@article{wijegunawardena2023-37235776,
  author  = {Wijegunawardena, Gayani and Castillo, Erika and Henrickson, Brandy and Davis, Regan and Condello, Carlo and Wu, Haifan},
  title   = {{Total Chemical Synthesis of Glycosylated TREM2 Ectodomain}},
  journal = {ACS chemical neuroscience},
  year    = {2023},
  doi     = {10.1021/acschemneuro.3c00257},
  pmid    = {37235776},
  url     = {https://doi.org/10.1021/acschemneuro.3c00257}
}

@article{tapiamonsalves2023-37182572,
  author  = {Tapia-Monsalves, Carola and Olesen, Margrethe A and Villavicencio-Tejo, Francisca and Quintanilla, Rodrigo A},
  title   = {{Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3}},
  journal = {Molecular and cellular neurosciences},
  year    = {2023},
  doi     = {10.1016/j.mcn.2023.103861},
  pmid    = {37182572},
  url     = {https://doi.org/10.1016/j.mcn.2023.103861}
}

@article{yang2023-37176125,
  author  = {Yang, Youngsoon and Bagyinszky, Eva and An, Seong Soo A},
  title   = {{Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24098417},
  pmid    = {37176125},
  url     = {https://doi.org/10.3390/ijms24098417}
}

@article{luciani2023-37122097,
  author  = {Luciani, Marco and Montalbano, Mauro and Troncone, Luca and Bacchin, Camilla and Uchida, Keita and Daniele, Gianlorenzo and Wolf, Bethany Jacobs and Butler, Helen M and others},
  title   = {{Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy}},
  journal = {European heart journal},
  year    = {2023},
  doi     = {10.1093/eurheartj/ehad205},
  pmid    = {37122097},
  url     = {https://doi.org/10.1093/eurheartj/ehad205}
}

@article{kunz2023-36951649,
  author  = {Kunz, Dieter and Oster, Henrik and Rawashdeh, Oliver and Neumann, Wolf-Julian and Münte, Thomas and Berg, Daniela},
  title   = {{Sleep and circadian rhythms in α-synucleinopathies-Perspectives for disease modification}},
  journal = {Acta physiologica (Oxford, England)},
  year    = {2023},
  doi     = {10.1111/apha.13966},
  pmid    = {36951649},
  url     = {https://doi.org/10.1111/apha.13966}
}

@article{praschberger2023-36948206,
  author  = {Praschberger, Roman and Kuenen, Sabine and Schoovaerts, Nils and Kaempf, Natalie and Singh, Jeevanjot and Janssens, Jasper and Swerts, Jef and Nachman, Eliana and others},
  title   = {{Neuronal identity defines α-synuclein and tau toxicity}},
  journal = {Neuron},
  year    = {2023},
  doi     = {10.1016/j.neuron.2023.02.033},
  pmid    = {36948206},
  url     = {https://doi.org/10.1016/j.neuron.2023.02.033}
}

@article{jagtap2023-36968195,
  author  = {Jagtap, Yuvraj Anandrao and Kumar, Prashant and Kinger, Sumit and Dubey, Ankur Rakesh and Choudhary, Akash and Gutti, Ravi Kumar and Singh, Sarika and Jha, Hem Chandra and others},
  title   = {{Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing}},
  journal = {Frontiers in cell and developmental biology},
  year    = {2023},
  doi     = {10.3389/fcell.2023.1146564},
  pmid    = {36968195},
  url     = {https://doi.org/10.3389/fcell.2023.1146564}
}

@article{tsoi2023-36834792,
  author  = {Tsoi, Phoebe S and Quan, My Diem and Ferreon, Josephine C and Ferreon, Allan Chris M},
  title   = {{Aggregation of Disordered Proteins Associated with Neurodegeneration}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24043380},
  pmid    = {36834792},
  url     = {https://doi.org/10.3390/ijms24043380}
}

@article{lee2023-36710361,
  author  = {Lee, Sang Hun and Bolshakov, Vadim Y and Shen, Jie},
  title   = {{Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus}},
  journal = {Molecular brain},
  year    = {2023},
  doi     = {10.1186/s13041-023-01009-x},
  pmid    = {36710361},
  url     = {https://doi.org/10.1186/s13041-023-01009-x}
}

@article{li2023-36717015,
  author  = {Li, Longfei and Miao, Jin and Jiang, Yanli and Dai, Chun-Ling and Iqbal, Khalid and Liu, Fei and Chu, Dandan},
  title   = {{Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice}},
  journal = {Experimental neurology},
  year    = {2023},
  doi     = {10.1016/j.expneurol.2023.114337},
  pmid    = {36717015},
  url     = {https://doi.org/10.1016/j.expneurol.2023.114337}
}

@article{cozachenco2023-36693451,
  author  = {Cozachenco, Danielle and Ribeiro, Felipe C and Ferreira, Sergio T},
  title   = {{Defective proteostasis in Alzheimer's disease}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2023.101862},
  pmid    = {36693451},
  url     = {https://doi.org/10.1016/j.arr.2023.101862}
}

@article{chu2023-36633448,
  author  = {Chu, Yuan-Ping and Ho, Pei-Chuan and Tsai, Kuen-Jer},
  title   = {{TTR (transthyretin) leads the autophagy disaster relief team against TARDBP/TDP-43 proteinopathy}},
  journal = {Autophagy},
  year    = {2023},
  doi     = {10.1080/15548627.2023.2167690},
  pmid    = {36633448},
  url     = {https://doi.org/10.1080/15548627.2023.2167690}
}

@article{liu2023-36621732,
  author  = {Liu, Xin and She, Weiyi and Sung, Herman H-Y and Williams, Ian D and Qian, Peiyuan},
  title   = {{Tau-aggregation inhibitors derived from Streptomyces tendae MCCC 1A01534 protect HT22 cells against okadaic acid-induced damage}},
  journal = {International journal of biological macromolecules},
  year    = {2023},
  doi     = {10.1016/j.ijbiomac.2023.123170},
  pmid    = {36621732},
  url     = {https://doi.org/10.1016/j.ijbiomac.2023.123170}
}

@article{grochowska2023-36594364,
  author  = {Grochowska, Katarzyna M and Gomes, Guilherme M and Raman, Rajeev and Kaushik, Rahul and Sosulina, Liudmila and Kaneko, Hiroshi and Oelschlegel, Anja M and Yuanxiang, PingAn and others},
  title   = {{Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease}},
  journal = {The EMBO journal},
  year    = {2023},
  doi     = {10.15252/embj.2022112453},
  pmid    = {36594364},
  url     = {https://doi.org/10.15252/embj.2022112453}
}

@article{lardelli2023-37718800,
  author  = {Lardelli, Michael},
  title   = {{An Alternative View of Familial Alzheimer's Disease Genetics}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2023},
  doi     = {10.3233/jad-230313},
  pmid    = {37718800},
  url     = {https://doi.org/10.3233/jad-230313}
}

@article{panza2023-37620094,
  author  = {Panza, Francesco and Solfrizzi, Vincenzo and Daniele, Antonio and Lozupone, Madia},
  title   = {{Passive tau-based immunotherapy for tauopathies}},
  journal = {Handbook of clinical neurology},
  year    = {2023},
  doi     = {10.1016/b978-0-323-98817-9.00029-6},
  pmid    = {37620094},
  url     = {https://doi.org/10.1016/b978-0-323-98817-9.00029-6}
}

@article{gao2023-37418213,
  author  = {Gao, Shudan and Wang, Yun and Ma, Tao and Zhang, Junying},
  title   = {{The Late Stage of Abnormal Aging: Dementia}},
  journal = {Advances in experimental medicine and biology},
  year    = {2023},
  doi     = {10.1007/978-981-99-1627-6_12},
  pmid    = {37418213},
  url     = {https://doi.org/10.1007/978-981-99-1627-6_12}
}

@article{xylaki2023-36744345,
  author  = {Xylaki, Mary and Paiva, Isabel and Al-Azzani, Mohammed and Gerhardt, Ellen and Jain, Gaurav and Islam, Md Rezaul and Vasili, Eftychia and Wassouf, Zinah and others},
  title   = {{miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy}},
  journal = {Journal of Parkinson's disease},
  year    = {2023},
  doi     = {10.3233/jpd-225055},
  pmid    = {36744345},
  url     = {https://doi.org/10.3233/jpd-225055}
}

@article{neha2023-36529440,
  author  = {Neha and Parvez, Suhel},
  title   = {{Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer's disease}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2022.101815},
  pmid    = {36529440},
  url     = {https://doi.org/10.1016/j.arr.2022.101815}
}

@article{brown2022-36517890,
  author  = {Brown, Jennifer L and Hart, Damyan W and Boyle, Gabriel E and Brown, Taylor G and LaCroix, Michael and Baraibar, Andrés M and Pelzel, Ross and Kim, Minwoo and others},
  title   = {{SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex}},
  journal = {Acta neuropathologica communications},
  year    = {2022},
  doi     = {10.1186/s40478-022-01480-y},
  pmid    = {36517890},
  url     = {https://doi.org/10.1186/s40478-022-01480-y}
}

@article{piconpages2022-36499491,
  author  = {Picón-Pagès, Pol and Fanlo-Ucar, Hugo and Herrera-Fernández, Víctor and Ausellé-Bosch, Sira and Galera-López, Lorena and Gutiérrez, Daniela A and Ozaita, Andrés and Álvarez, Alejandra R and others},
  title   = {{Amyloid β-Peptide Causes the Permanent Activation of CaMKIIα through Its Oxidation}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms232315169},
  pmid    = {36499491},
  url     = {https://doi.org/10.3390/ijms232315169}
}

@article{zhao2023-36422837,
  author  = {Zhao, Shuai and Fan, Ziqi and Zhang, Xinyi and Li, Zheyu and Shen, Ting and Li, Kaicheng and Yan, Yaping and Yuan, Yunfeng and others},
  title   = {{Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2023},
  doi     = {10.1007/s13311-022-01316-6},
  pmid    = {36422837},
  url     = {https://doi.org/10.1007/s13311-022-01316-6}
}

@article{karimi2022-36410182,
  author  = {Karimi, Nastaran and Çatak, Feyza Bayram and Arslan, Ebru and Saghazadeh, Amene and Rezaei, Nima},
  title   = {{Tau immunotherapy in Alzheimer's disease and progressive supranuclear palsy}},
  journal = {International immunopharmacology},
  year    = {2022},
  doi     = {10.1016/j.intimp.2022.109445},
  pmid    = {36410182},
  url     = {https://doi.org/10.1016/j.intimp.2022.109445}
}

@article{makhdoomi2023-36208459,
  author  = {Makhdoomi, Sajjad and Ariafar, Saba and Mirzaei, Fatemeh and Mohammadi, Mojdeh},
  title   = {{Aluminum neurotoxicity and autophagy: a mechanistic view}},
  journal = {Neurological research},
  year    = {2023},
  doi     = {10.1080/01616412.2022.2132727},
  pmid    = {36208459},
  url     = {https://doi.org/10.1080/01616412.2022.2132727}
}

@article{buendia2022-36291206,
  author  = {Buendía, Débora and Guncay, Tatiana and Oyanedel, Macarena and Lemus, Makarena and Weinstein, Alejandro and Ardiles, Álvaro O and Marcos, José and Fernandes, Adriana and others},
  title   = {{The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model}},
  journal = {Brain sciences},
  year    = {2022},
  doi     = {10.3390/brainsci12101272},
  pmid    = {36291206},
  url     = {https://doi.org/10.3390/brainsci12101272}
}

@article{dhakal2022-36116552,
  author  = {Dhakal, Shailendra and Robang, Alicia S and Bhatt, Nemil and Puangmalai, Nicha and Fung, Leiana and Kayed, Rakez and Paravastu, Anant K and Rangachari, Vijayaraghavan},
  title   = {{Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein}},
  journal = {The Journal of biological chemistry},
  year    = {2022},
  doi     = {10.1016/j.jbc.2022.102498},
  pmid    = {36116552},
  url     = {https://doi.org/10.1016/j.jbc.2022.102498}
}

@article{andersen2022-36099918,
  author  = {Andersen, Olav M and Bøgh, Nikolaj and Landau, Anne M and Pløen, Gro G and Jensen, Anne Mette G and Monti, Giulia and Ulhøi, Benedicte P and Nyengaard, Jens R and others},
  title   = {{A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency}},
  journal = {Cell reports. Medicine},
  year    = {2022},
  doi     = {10.1016/j.xcrm.2022.100740},
  pmid    = {36099918},
  url     = {https://doi.org/10.1016/j.xcrm.2022.100740}
}

@article{levy2022-36160048,
  author  = {Levy, Simon A and Zuniga, Gabrielle and Gonzalez, Elias M and Butler, David and Temple, Sally and Frost, Bess},
  title   = {{TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy}},
  journal = {Cell reports methods},
  year    = {2022},
  doi     = {10.1016/j.crmeth.2022.100292},
  pmid    = {36160048},
  url     = {https://doi.org/10.1016/j.crmeth.2022.100292}
}

@article{alipour2022-36087426,
  author  = {Alipour, Masoume and Tebianian, Majid and Tofigh, Nahid and Taheri, Reyhaneh Sadat and Mousavi, Sayed Alireza and Naseri, Asal and Ahmadi, Amin and Munawar, Nayla and others},
  title   = {{Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models}},
  journal = {Neuropeptides},
  year    = {2022},
  doi     = {10.1016/j.npep.2022.102285},
  pmid    = {36087426},
  url     = {https://doi.org/10.1016/j.npep.2022.102285}
}

@article{koper2022-36057624,
  author  = {Koper, Marta J and Tomé, Sandra O and Gawor, Klara and Belet, Annelies and Van Schoor, Evelien and Schaeverbeke, Jolien and Vandenberghe, Rik and Vandenbulcke, Mathieu and others},
  title   = {{LATE-NC aggravates GVD-mediated necroptosis in Alzheimer's disease}},
  journal = {Acta neuropathologica communications},
  year    = {2022},
  doi     = {10.1186/s40478-022-01432-6},
  pmid    = {36057624},
  url     = {https://doi.org/10.1186/s40478-022-01432-6}
}

@article{zhang2022-36092715,
  author  = {Zhang, Huiqin and Jiang, Xuefan and Ma, Lina and Wei, Wei and Li, Zehui and Chang, Surui and Wen, Jiayu and Sun, Jiahui and others},
  title   = {{Role of Aβ in Alzheimer's-related synaptic dysfunction}},
  journal = {Frontiers in cell and developmental biology},
  year    = {2022},
  doi     = {10.3389/fcell.2022.964075},
  pmid    = {36092715},
  url     = {https://doi.org/10.3389/fcell.2022.964075}
}

@article{ahmad2023-36911088,
  author  = {Ahmad, Faizan and Sachdeva, Punya and Sarkar, Jasmine and Izhaar, Raafiah},
  title   = {{Circadian dysfunction and Alzheimer's disease - An updated review}},
  journal = {Aging medicine (Milton (N.S.W))},
  year    = {2023},
  doi     = {10.1002/agm2.12221},
  pmid    = {36911088},
  url     = {https://doi.org/10.1002/agm2.12221}
}

@article{inoue2022-35916996,
  author  = {Inoue, Yasuteru and Tasaki, Masayoshi and Masuda, Teruaki and Misumi, Yohei and Nomura, Toshiya and Ando, Yukio and Ueda, Mitsuharu},
  title   = {{α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2022},
  doi     = {10.1007/s00018-022-04493-x},
  pmid    = {35916996},
  url     = {https://doi.org/10.1007/s00018-022-04493-x}
}

@article{boudesco2022-35912412,
  author  = {Boudesco, Christophe and Nonneman, Annelies and Cinti, Alessandro and Picardi, Paola and Redaelli, Loredana and Swijsen, Sofie and Roewe, Julian and Reinhardt, Peter and others},
  title   = {{Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells}},
  journal = {Glia},
  year    = {2022},
  doi     = {10.1002/glia.24252},
  pmid    = {35912412},
  url     = {https://doi.org/10.1002/glia.24252}
}

@article{siddique2022-35992376,
  author  = {Siddique, Yasir Hasan and Naz, Falaq and Rahul and Varshney, Himanshi},
  title   = {{Comparative study of rivastigmine and galantamine on the transgenic Drosophila model of Alzheimer's disease}},
  journal = {Current research in pharmacology and drug discovery},
  year    = {2022},
  doi     = {10.1016/j.crphar.2022.100120},
  pmid    = {35992376},
  url     = {https://doi.org/10.1016/j.crphar.2022.100120}
}

@article{oterogarcia2022-35882228,
  author  = {Otero-Garcia, Marcos and Mahajani, Sameehan U and Wakhloo, Debia and Tang, Weijing and Xue, Yue-Qiang and Morabito, Samuel and Pan, Jie and Oberhauser, Jane and others},
  title   = {{Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease}},
  journal = {Neuron},
  year    = {2022},
  doi     = {10.1016/j.neuron.2022.06.021},
  pmid    = {35882228},
  url     = {https://doi.org/10.1016/j.neuron.2022.06.021}
}

@article{ashraf2022-35889524,
  author  = {Ashraf, Ghulam Md and DasGupta, Debarati and Alam, Mohammad Zubair and Baeesa, Saleh S and Alghamdi, Badrah S and Anwar, Firoz and Alqurashi, Thamer M A and Sharaf, Sharaf E and others},
  title   = {{Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2022},
  doi     = {10.3390/molecules27144652},
  pmid    = {35889524},
  url     = {https://doi.org/10.3390/molecules27144652}
}

@article{choi2022-35850693,
  author  = {Choi, Hee-Jeong and Park, Jin-Hee and Jeong, Yoo Joo and Hwang, Jeong-Woo and Lee, Soojung and Lee, Heeyong and Seol, Eunyoung and Kim, Ik-Whi and others},
  title   = {{Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice}},
  journal = {Molecular brain},
  year    = {2022},
  doi     = {10.1186/s13041-022-00948-1},
  pmid    = {35850693},
  url     = {https://doi.org/10.1186/s13041-022-00948-1}
}

@article{ntsapi2022-40396009,
  author  = {Ntsapi, Claudia M and du Toit, Andre and Loos, Ben},
  title   = {{Favorably against the odds - autophagy control despite advanced amyloid- ß toxicity}},
  journal = {Autophagy reports},
  year    = {2022},
  doi     = {10.1080/27694127.2022.2082631},
  pmid    = {40396009},
  url     = {https://doi.org/10.1080/27694127.2022.2082631}
}

@article{williams2022-35440098,
  author  = {Williams, Tristan and Ruiz, Alejandra Jolie and Ruiz, Angelica Maria and Vo, Quan and Tsering, Wangchen and Xu, Guilian and McFarland, Karen and Giasson, Benoit I and others},
  title   = {{Impact of APOE genotype on prion-type propagation of tauopathy}},
  journal = {Acta neuropathologica communications},
  year    = {2022},
  doi     = {10.1186/s40478-022-01359-y},
  pmid    = {35440098},
  url     = {https://doi.org/10.1186/s40478-022-01359-y}
}

@article{liu2022-35395400,
  author  = {Liu, Wei and Wang, Gang and Wang, Zhiwen and Wang, Guan and Huang, Jianping and Liu, Bo},
  title   = {{Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases}},
  journal = {Drug discovery today},
  year    = {2022},
  doi     = {10.1016/j.drudis.2022.04.003},
  pmid    = {35395400},
  url     = {https://doi.org/10.1016/j.drudis.2022.04.003}
}

@article{musardo2022-35390543,
  author  = {Musardo, Stefano and Therin, Sebastien and Pelucchi, Silvia and D'Andrea, Laura and Stringhi, Ramona and Ribeiro, Ana and Manca, Annalisa and Balducci, Claudia and others},
  title   = {{The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer's disease}},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year    = {2022},
  doi     = {10.1016/j.ymthe.2022.03.024},
  pmid    = {35390543},
  url     = {https://doi.org/10.1016/j.ymthe.2022.03.024}
}

@article{konstantinidis2022-35505961,
  author  = {Konstantinidis, Evangelos and Molisak, Agnieszka and Perrin, Florian and Streubel-Gallasch, Linn and Fayad, Sarah and Kim, Daniel Y and Petri, Karl and Aryee, Martin J and others},
  title   = {{CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation}},
  journal = {Molecular therapy. Nucleic acids},
  year    = {2022},
  doi     = {10.1016/j.omtn.2022.03.022},
  pmid    = {35505961},
  url     = {https://doi.org/10.1016/j.omtn.2022.03.022}
}

@article{tan2022-35454096,
  author  = {Tan, Li Yang and Tang, Kwan Hou and Lim, Lynette Yu You and Ong, Jia Xin and Park, Hyokeun and Jung, Sangyong},
  title   = {{α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword}},
  journal = {Biomolecules},
  year    = {2022},
  doi     = {10.3390/biom12040507},
  pmid    = {35454096},
  url     = {https://doi.org/10.3390/biom12040507}
}

@article{jin2022-35298330,
  author  = {Jin, Chen and Wang, Jiaoni and Wang, Yumeng and Jia, Bojun and Guo, Xuefei and Yang, Guanghui and Xu, Peng and Greengard, Paul and others},
  title   = {{Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2022},
  doi     = {10.1073/pnas.2122292119},
  pmid    = {35298330},
  url     = {https://doi.org/10.1073/pnas.2122292119}
}

@article{vecchio2022-35321401,
  author  = {Vecchio, Filomena Lo and Bisceglia, Paola and Imbimbo, Bruno Pietro and Lozupone, Madia and Latino, Raffaela Rita and Resta, Emanuela and Leone, Maurizio and Solfrizzi, Vincenzo and others},
  title   = {{Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer's disease?}},
  journal = {Therapeutic advances in chronic disease},
  year    = {2022},
  doi     = {10.1177/20406223221081605},
  pmid    = {35321401},
  url     = {https://doi.org/10.1177/20406223221081605}
}

@article{eshraghi2022-35304223,
  author  = {Eshraghi, Mehdi and Ahmadi, Mazaher and Afshar, Saeid and Lorzadeh, Shahrokh and Adlimoghaddam, Aida and Jalal, Nahid Rezvani and West, Ryan and Dastghaib, Sanaz and others},
  title   = {{Enhancing autophagy in Alzheimer's disease through drug repositioning}},
  journal = {Pharmacology \& therapeutics},
  year    = {2022},
  doi     = {10.1016/j.pharmthera.2022.108171},
  pmid    = {35304223},
  url     = {https://doi.org/10.1016/j.pharmthera.2022.108171}
}

@article{munari2022-35107860,
  author  = {Munari, Francesca and Mollica, Luca and Valente, Carlo and Parolini, Francesca and Kachoie, Elham Ataie and Arrigoni, Giorgio and D'Onofrio, Mariapina and Capaldi, Stefano and others},
  title   = {{Structural Basis for Chaperone-Independent Ubiquitination of Tau Protein by Its E3 Ligase CHIP}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2022},
  doi     = {10.1002/anie.202112374},
  pmid    = {35107860},
  url     = {https://doi.org/10.1002/anie.202112374}
}

@article{vagenknecht2022-35128565,
  author  = {Vagenknecht, Patrick and Luzgin, Artur and Ono, Maiko and Ji, Bin and Higuchi, Makoto and Noain, Daniela and Maschio, Cinzia A and Sobek, Jens and others},
  title   = {{Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2022},
  doi     = {10.1007/s00259-022-05708-w},
  pmid    = {35128565},
  url     = {https://doi.org/10.1007/s00259-022-05708-w}
}

@article{krogsaeter2022-35144097,
  author  = {Krogsaeter, Einar and Rosato, Anna Scotto and Grimm, Christian},
  title   = {{TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?}},
  journal = {Cell calcium},
  year    = {2022},
  doi     = {10.1016/j.ceca.2022.102553},
  pmid    = {35144097},
  url     = {https://doi.org/10.1016/j.ceca.2022.102553}
}

@article{talebi2022-35093121,
  author  = {Talebi, Marjan and Vadoud, Seyyed Ali Mohammadi and Haratian, Alireza and Talebi, Mohsen and Farkhondeh, Tahereh and Pourbagher-Shahri, Ali Mohammad and Samarghandian, Saeed},
  title   = {{The interplay between oxidative stress and autophagy: focus on the development of neurological diseases}},
  journal = {Behavioral and brain functions : BBF},
  year    = {2022},
  doi     = {10.1186/s12993-022-00187-3},
  pmid    = {35093121},
  url     = {https://doi.org/10.1186/s12993-022-00187-3}
}

@article{tecalcocruz2022-35083609,
  author  = {Tecalco-Cruz, Angeles C and Pedraza-Chaverri, José and Briones-Herrera, Alfredo and Cruz-Ramos, Eduardo and López-Canovas, Lilia and Zepeda-Cervantes, Jesús},
  title   = {{Protein degradation-associated mechanisms that are affected in Alzheimer´s disease}},
  journal = {Molecular and cellular biochemistry},
  year    = {2022},
  doi     = {10.1007/s11010-021-04334-8},
  pmid    = {35083609},
  url     = {https://doi.org/10.1007/s11010-021-04334-8}
}

@article{lagerupprecht2022-35510183,
  author  = {Lage-Rupprecht, Vanessa and Schultz, Bruce and Dick, Justus and Namysl, Marcin and Zaliani, Andrea and Gebel, Stephan and Pless, Ole and Reinshagen, Jeanette and others},
  title   = {{A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism}},
  journal = {Patterns (New York, N.Y.)},
  year    = {2022},
  doi     = {10.1016/j.patter.2021.100433},
  pmid    = {35510183},
  url     = {https://doi.org/10.1016/j.patter.2021.100433}
}

@article{ni2021-35145392,
  author  = {Ni, Ruiqing},
  title   = {{Magnetic Resonance Imaging in Tauopathy Animal Models}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.791679},
  pmid    = {35145392},
  url     = {https://doi.org/10.3389/fnagi.2021.791679}
}

@article{inuzuka2022-35237768,
  author  = {Inuzuka, Hiroyuki and Liu, Jing and Wei, Wenyi and Rezaeian, Abdol-Hossein},
  title   = {{PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives}},
  journal = {Acta materia medica},
  year    = {2022},
  doi     = {10.15212/amm-2021-0001},
  pmid    = {35237768},
  url     = {https://doi.org/10.15212/amm-2021-0001}
}

@article{zernov2022-35079728,
  author  = {Zernov, Nikita and Bezprozvanny, Ilya and Popugaeva, Elena},
  title   = {{CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines}},
  journal = {IBRO neuroscience reports},
  year    = {2022},
  doi     = {10.1016/j.ibneur.2022.01.001},
  pmid    = {35079728},
  url     = {https://doi.org/10.1016/j.ibneur.2022.01.001}
}

@article{zhang2022-35871344,
  author  = {Zhang, Yangyang and Yang, Yin and Hu, Zhengtao and Zhu, Manyi and Qin, Shuangying and Yu, Pengpeng and Li, Bo and Xu, Jitian and others},
  title   = {{Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220351},
  pmid    = {35871344},
  url     = {https://doi.org/10.3233/jad-220351}
}

@article{hernandezsapiens2022-34100423,
  author  = {Hernandez-Sapiens, Mercedes A and Reza-Zaldívar, Edwin E and Márquez-Aguirre, Ana L and Gómez-Pinedo, Ulises and Matias-Guiu, Jorge and Cevallos, Ricardo R and Mateos-Díaz, Juan C and Sánchez-González, Víctor J and others},
  title   = {{Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease}},
  journal = {Neural regeneration research},
  year    = {2022},
  doi     = {10.4103/1673-5374.313016},
  pmid    = {34100423},
  url     = {https://doi.org/10.4103/1673-5374.313016}
}

@article{frame2022-35599482,
  author  = {Frame, Gabrielle and Schuller, Adam and Smith, Matthew A and Crish, Samuel D and Dengler-Crish, Christine M},
  title   = {{Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer's Disease Mice}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220016},
  pmid    = {35599482},
  url     = {https://doi.org/10.3233/jad-220016}
}

@article{nisa2021-34433343,
  author  = {Nisa, Fatema Yasmin and Rahman, Md Atiar and Hossen, Md Amjad and Khan, Mohammad Forhad and Khan, Md Asif Nadim and Majid, Mumtahina and Sultana, Farjana and Haque, Md Areeful},
  title   = {{Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight}},
  journal = {Annals of medicine},
  year    = {2021},
  doi     = {10.1080/07853890.2021.1966088},
  pmid    = {34433343},
  url     = {https://doi.org/10.1080/07853890.2021.1966088}
}

@article{kroth2021-34839158,
  author  = {Kroth, Heiko and Oden, Felix and Serra, Andreia Monica and Molette, Jerome and Mueller, Andre and Berndt, Mathias and Capotosti, Francesca and Gabellieri, Emanuele and others},
  title   = {{Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core}},
  journal = {Bioorganic \& medicinal chemistry},
  year    = {2021},
  doi     = {10.1016/j.bmc.2021.116528},
  pmid    = {34839158},
  url     = {https://doi.org/10.1016/j.bmc.2021.116528}
}

@article{simon2021-34798911,
  author  = {Simon, Christopher and Soga, Tomoko and Okano, Hirotaka James and Parhar, Ishwar},
  title   = {{α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox}},
  journal = {Cell \& bioscience},
  year    = {2021},
  doi     = {10.1186/s13578-021-00709-y},
  pmid    = {34798911},
  url     = {https://doi.org/10.1186/s13578-021-00709-y}
}

@article{mukherjee2021-34867295,
  author  = {Mukherjee, Sitabja and Mishra, Awdhesh Kumar and Peer, G D Ghouse and Bagabir, Sali Abubaker and Haque, Shafiul and Pandey, Ramendra Pati and Raj, V Samuel and Jain, Neeraj and others},
  title   = {{The Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.767493},
  pmid    = {34867295},
  url     = {https://doi.org/10.3389/fnagi.2021.767493}
}

@article{wu2021-34753506,
  author  = {Wu, Moxin and Zhang, Manqing and Yin, Xiaoping and Chen, Kai and Hu, Zhijian and Zhou, Qin and Cao, Xianming and Chen, Zhiying and others},
  title   = {{The role of pathological tau in synaptic dysfunction in Alzheimer's diseases}},
  journal = {Translational neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s40035-021-00270-1},
  pmid    = {34753506},
  url     = {https://doi.org/10.1186/s40035-021-00270-1}
}

@article{si2022-34758364,
  author  = {Si, Youwen and Guo, Chao and Xiao, Fan and Mei, Bing and Meng, Bo},
  title   = {{Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice}},
  journal = {Behavioural brain research},
  year    = {2022},
  doi     = {10.1016/j.bbr.2021.113652},
  pmid    = {34758364},
  url     = {https://doi.org/10.1016/j.bbr.2021.113652}
}

@article{hill2021-34737403,
  author  = {Hill, Emily and Karikari, Thomas K and Lantero-Rodriguez, Juan and Zetterberg, Henrik and Blennow, Kaj and Richardson, Magnus J and Wall, Mark J},
  title   = {{Truncating tau reveals different pathophysiological actions of oligomers in single neurons}},
  journal = {Communications biology},
  year    = {2021},
  doi     = {10.1038/s42003-021-02791-x},
  pmid    = {34737403},
  url     = {https://doi.org/10.1038/s42003-021-02791-x}
}

@article{kakuda2021-34728605,
  author  = {Kakuda, Nobuto and Takami, Mako and Okochi, Masayasu and Kasuga, Kensaku and Ihara, Yasuo and Ikeuchi, Takeshi},
  title   = {{Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation}},
  journal = {Translational psychiatry},
  year    = {2021},
  doi     = {10.1038/s41398-021-01684-1},
  pmid    = {34728605},
  url     = {https://doi.org/10.1038/s41398-021-01684-1}
}

@article{hommen2022-34689261,
  author  = {Hommen, Franziska and Bilican, Saygın and Vilchez, David},
  title   = {{Protein clearance strategies for disease intervention}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2022},
  doi     = {10.1007/s00702-021-02431-y},
  pmid    = {34689261},
  url     = {https://doi.org/10.1007/s00702-021-02431-y}
}

@article{zhang2021-34671600,
  author  = {Zhang, Haorui and Zablah, Youssif Ben and Zhang, Haiwang and Jia, Zhengping},
  title   = {{Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders}},
  journal = {Frontiers in cell and developmental biology},
  year    = {2021},
  doi     = {10.3389/fcell.2021.729076},
  pmid    = {34671600},
  url     = {https://doi.org/10.3389/fcell.2021.729076}
}

@article{marchesi2021-34572041,
  author  = {Marchesi, Nicoletta and Fahmideh, Foroogh and Boschi, Federica and Pascale, Alessia and Barbieri, Annalisa},
  title   = {{Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10092394},
  pmid    = {34572041},
  url     = {https://doi.org/10.3390/cells10092394}
}

@article{lloyd2021-34503546,
  author  = {Lloyd, Grace M and Dhillon, Jess-Karan S and Gorion, Kimberly-Marie M and Riffe, Cara and Fromholt, Susan E and Xia, Yuxing and Giasson, Benoit I and Borchelt, David R},
  title   = {{Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00486-9},
  pmid    = {34503546},
  url     = {https://doi.org/10.1186/s13024-021-00486-9}
}

@article{robbins2021-34503576,
  author  = {Robbins, Miranda and Clayton, Emma and Schierle, Gabriele S Kaminski},
  title   = {{Synaptic tau: A pathological or physiological phenomenon?}},
  journal = {Acta neuropathologica communications},
  year    = {2021},
  doi     = {10.1186/s40478-021-01246-y},
  pmid    = {34503576},
  url     = {https://doi.org/10.1186/s40478-021-01246-y}
}

@article{nam2021-34482237,
  author  = {Nam, Geewoo and Suh, Jong-Min and Yi, Yelim and Lim, Mi Hee},
  title   = {{Drug repurposing: small molecules against Cu(II)-amyloid-β and free radicals}},
  journal = {Journal of inorganic biochemistry},
  year    = {2021},
  doi     = {10.1016/j.jinorgbio.2021.111592},
  pmid    = {34482237},
  url     = {https://doi.org/10.1016/j.jinorgbio.2021.111592}
}

@article{zhang2021-34432352,
  author  = {Zhang, Yali and Fan, Xing and Su, Zhangyao and Yuan, Tianli and Yin, Haimeng and Gu, Haohao and Zuo, Yue and Chen, Shiyin and others},
  title   = {{Pretreatment with metformin prevents microcystin-LR-induced tau hyperphosphorylation via mTOR-dependent PP2A and GSK-3β activation}},
  journal = {Environmental toxicology},
  year    = {2021},
  doi     = {10.1002/tox.23354},
  pmid    = {34432352},
  url     = {https://doi.org/10.1002/tox.23354}
}

@article{moons2022-34399146,
  author  = {Moons, Lieve and De Groef, Lies},
  title   = {{Multimodal retinal imaging to detect and understand Alzheimer's and Parkinson's disease}},
  journal = {Current opinion in neurobiology},
  year    = {2022},
  doi     = {10.1016/j.conb.2021.07.007},
  pmid    = {34399146},
  url     = {https://doi.org/10.1016/j.conb.2021.07.007}
}

@article{zablah2021-34440848,
  author  = {Zablah, Youssif Ben and Zhang, Haiwang and Gugustea, Radu and Jia, Zhengping},
  title   = {{LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10082079},
  pmid    = {34440848},
  url     = {https://doi.org/10.3390/cells10082079}
}

@article{hamano2021-34299093,
  author  = {Hamano, Tadanori and Enomoto, Soichi and Shirafuji, Norimichi and Ikawa, Masamichi and Yamamura, Osamu and Yen, Shu-Hui and Nakamoto, Yasunari},
  title   = {{Autophagy and Tau Protein}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22147475},
  pmid    = {34299093},
  url     = {https://doi.org/10.3390/ijms22147475}
}

@article{nakamura2021-34224817,
  author  = {Nakamura, Tomohiro and Oh, Chang-Ki and Zhang, Xu and Lipton, Stuart A},
  title   = {{Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration}},
  journal = {Free radical biology \& medicine},
  year    = {2021},
  doi     = {10.1016/j.freeradbiomed.2021.07.002},
  pmid    = {34224817},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2021.07.002}
}

@article{hyun2021-34202541,
  author  = {Hyun, Soonsil and Shin, Dongyun},
  title   = {{Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases}},
  journal = {Life (Basel, Switzerland)},
  year    = {2021},
  doi     = {10.3390/life11070607},
  pmid    = {34202541},
  url     = {https://doi.org/10.3390/life11070607}
}

@article{andradetalavera2021-34220451,
  author  = {Andrade-Talavera, Yuniesky and Rodríguez-Moreno, Antonio},
  title   = {{Synaptic Plasticity and Oscillations in Alzheimer's Disease: A Complex Picture of a Multifaceted Disease}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2021},
  doi     = {10.3389/fnmol.2021.696476},
  pmid    = {34220451},
  url     = {https://doi.org/10.3389/fnmol.2021.696476}
}

@article{bourdenx2021-34110247,
  author  = {Bourdenx, Mathieu and Gavathiotis, Evripidis and Cuervo, Ana Maria},
  title   = {{Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis}},
  journal = {Autophagy},
  year    = {2021},
  doi     = {10.1080/15548627.2021.1935007},
  pmid    = {34110247},
  url     = {https://doi.org/10.1080/15548627.2021.1935007}
}

@article{chua2022-34057020,
  author  = {Chua, Jason P and De Calbiac, Hortense and Kabashi, Edor and Barmada, Sami J},
  title   = {{Autophagy and ALS: mechanistic insights and therapeutic implications}},
  journal = {Autophagy},
  year    = {2022},
  doi     = {10.1080/15548627.2021.1926656},
  pmid    = {34057020},
  url     = {https://doi.org/10.1080/15548627.2021.1926656}
}

@article{wolfe2021-35295247,
  author  = {Wolfe, Michael S},
  title   = {{Targeting γ-Secretase for Familial Alzheimer's Disease}},
  journal = {Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents},
  year    = {2021},
  doi     = {10.1007/s00044-021-02744-3},
  pmid    = {35295247},
  url     = {https://doi.org/10.1007/s00044-021-02744-3}
}

@article{bluhm2021-34064208,
  author  = {Bluhm, Alexandra and Schrempel, Sarah and von Hörsten, Stephan and Schulze, Anja and Roßner, Steffen},
  title   = {{Proteolytic α-Synuclein Cleavage in Health and Disease}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22115450},
  pmid    = {34064208},
  url     = {https://doi.org/10.3390/ijms22115450}
}

@article{ingham2021-34009955,
  author  = {Ingham, David J and Blankenfeld, Bryce R and Chacko, Shibin and Perera, Chamani and Oakley, Berl R and Gamblin, Truman Christopher},
  title   = {{Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition}},
  journal = {Biochemistry},
  year    = {2021},
  doi     = {10.1021/acs.biochem.1c00111},
  pmid    = {34009955},
  url     = {https://doi.org/10.1021/acs.biochem.1c00111}
}

@article{zhu2021-33999598,
  author  = {Zhu, Lin and Xu, Linlin and Wu, Xiaohui and Deng, Fei and Ma, Rujiang and Liu, Yang and Huang, Fan and Shi, Linqi},
  title   = {{Tau-Targeted Multifunctional Nanoinhibitor for Alzheimer's Disease}},
  journal = {ACS applied materials \& interfaces},
  year    = {2021},
  doi     = {10.1021/acsami.1c00257},
  pmid    = {33999598},
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}

@article{lopes2021-34054416,
  author  = {Lopes, Cátia R and Cunha, Rodrigo A and Agostinho, Paula},
  title   = {{Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer's Disease}},
  journal = {Frontiers in neuroscience},
  year    = {2021},
  doi     = {10.3389/fnins.2021.666710},
  pmid    = {34054416},
  url     = {https://doi.org/10.3389/fnins.2021.666710}
}

@article{park2021-33924878,
  author  = {Park, Hyungsun and Kim, Jongyoon and Shin, Chihoon and Lee, Seongju},
  title   = {{Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2021},
  doi     = {10.3390/antiox10050694},
  pmid    = {33924878},
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}

@article{pope2021-33899637,
  author  = {Pope, Evans D and Cordes, Laura and Shi, Jiong and Mari, Zoltan and Decourt, Boris and Sabbagh, Marwan Noel},
  title   = {{Dementia with Lewy bodies: emerging drug targets and therapeutics}},
  journal = {Expert opinion on investigational drugs},
  year    = {2021},
  doi     = {10.1080/13543784.2021.1916913},
  pmid    = {33899637},
  url     = {https://doi.org/10.1080/13543784.2021.1916913}
}

@article{bourdenx2021-33891876,
  author  = {Bourdenx, Mathieu and Martín-Segura, Adrián and Scrivo, Aurora and Rodriguez-Navarro, Jose A and Kaushik, Susmita and Tasset, Inmaculada and Diaz, Antonio and Storm, Nadia J and others},
  title   = {{Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome}},
  journal = {Cell},
  year    = {2021},
  doi     = {10.1016/j.cell.2021.03.048},
  pmid    = {33891876},
  url     = {https://doi.org/10.1016/j.cell.2021.03.048}
}

@article{speranza2021-33810328,
  author  = {Speranza, Luisa and di Porzio, Umberto and Viggiano, Davide and de Donato, Antonio and Volpicelli, Floriana},
  title   = {{Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10040735},
  pmid    = {33810328},
  url     = {https://doi.org/10.3390/cells10040735}
}

@article{roberts2021-33571523,
  author  = {Roberts, Jessica P and Stokoe, Sarah A and Sathler, Matheus F and Nichols, Robert A and Kim, Seonil},
  title   = {{Selective coactivation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction}},
  journal = {The Journal of biological chemistry},
  year    = {2021},
  doi     = {10.1016/j.jbc.2021.100402},
  pmid    = {33571523},
  url     = {https://doi.org/10.1016/j.jbc.2021.100402}
}

@article{arber2021-33440141,
  author  = {Arber, Charles and Lovejoy, Christopher and Harris, Lachlan and Willumsen, Nanet and Alatza, Argyro and Casey, Jackie M and Lines, Georgie and Kerins, Caoimhe and others},
  title   = {{Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2020.108615},
  pmid    = {33440141},
  url     = {https://doi.org/10.1016/j.celrep.2020.108615}
}

@article{alquezar2020-33488497,
  author  = {Alquezar, C. and Arya, S. and Kao, A. W.},
  title   = {{Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation}},
  journal = {Frontiers in neurology},
  year    = {2020},
  doi     = {10.3389/fneur.2020.595532},
  pmid    = {33488497},
  url     = {https://doi.org/10.3389/fneur.2020.595532}
}

@article{franic2021-33406777,
  author  = {Franić, Dina and Zubčić, Klara and Boban, Mirta},
  title   = {{Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance}},
  journal = {Biomolecules},
  year    = {2021},
  doi     = {10.3390/biom11010054},
  pmid    = {33406777},
  url     = {https://doi.org/10.3390/biom11010054}
}

@article{guo2021-33855942,
  author  = {Guo, Li and Ravindran, Nivedita and Shamsher, Ehtesham and Hill, Daniel and Cordeiro, M Francesca},
  title   = {{Retinal Changes in Transgenic Mouse Models of Alzheimer's Disease}},
  journal = {Current Alzheimer research},
  year    = {2021},
  doi     = {10.2174/1567205018666210414113634},
  pmid    = {33855942},
  url     = {https://doi.org/10.2174/1567205018666210414113634}
}

@article{wei2021-34057082,
  author  = {Wei, Wei and Liu, Yinghua and Dai, Chun-Ling and Baazaoui, Narjes and Tung, Yunn Chyn and Liu, Fei and Iqbal, Khalid},
  title   = {{Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-201599},
  pmid    = {34057082},
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}

@article{oberrauch2021-33524848,
  author  = {Oberrauch, Sara and Metha, Jeremy A and Brian, Maddison L and Barnes, Samuel A and Featherby, Travis J and Lawrence, Andrew J and Hoyer, Daniel and Murawski, Carsten and others},
  title   = {{Reward motivation and cognitive flexibility in tau null-mutation mice}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2020.12.017},
  pmid    = {33524848},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2020.12.017}
}

@article{weng2021-33422896,
  author  = {Weng, Fang-Lin and He, Ling},
  title   = {{Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2020.11.015},
  pmid    = {33422896},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2020.11.015}
}

@article{zhang2021-33268824,
  author  = {Zhang, Feng and Zhong, Ru-Jia and Cheng, Cheng and Li, Song and Le, Wei-Dong},
  title   = {{New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease}},
  journal = {Acta pharmacologica Sinica},
  year    = {2021},
  doi     = {10.1038/s41401-020-00565-5},
  pmid    = {33268824},
  url     = {https://doi.org/10.1038/s41401-020-00565-5}
}

@article{parnell2021-33189799,
  author  = {Parnell, Euan and Shapiro, Lauren P and Voorn, Roos A and Forrest, Marc P and Jalloul, Hiba A and Loizzo, Daniel D and Penzes, Peter},
  title   = {{KALRN: A central regulator of synaptic function and synaptopathies}},
  journal = {Gene},
  year    = {2021},
  doi     = {10.1016/j.gene.2020.145306},
  pmid    = {33189799},
  url     = {https://doi.org/10.1016/j.gene.2020.145306}
}

@article{quinn2020-33168089,
  author  = {Quinn, P. M. J. and Moreira, P. I. and Ambrósio, A. F. and Alves, C. H.},
  title   = {{PINK1/PARKIN signalling in neurodegeneration and neuroinflammation}},
  journal = {Acta neuropathologica communications},
  year    = {2020},
  doi     = {10.1186/s40478-020-01062-w},
  pmid    = {33168089},
  url     = {https://doi.org/10.1186/s40478-020-01062-w}
}

@article{dash2021-33181336,
  author  = {Dash, Raju and Ali, Md Chayan and Jahan, Israt and Munni, Yeasmin Akter and Mitra, Sarmistha and Hannan, Md Abdul and Timalsina, Binod and Oktaviani, Diyah Fatimah and others},
  title   = {{Emerging potential of cannabidiol in reversing proteinopathies}},
  journal = {Ageing research reviews},
  year    = {2021},
  doi     = {10.1016/j.arr.2020.101209},
  pmid    = {33181336},
  url     = {https://doi.org/10.1016/j.arr.2020.101209}
}

@article{qu2021-33098528,
  author  = {Qu, Wenhui and Suazo, Kiall F and Liu, Wenfeng and Cheng, Shaowu and Jeong, Angela and Hottman, David and Yuan, Li-Lian and Distefano, Mark D and others},
  title   = {{Neuronal Protein Farnesylation Regulates Hippocampal Synaptic Plasticity and Cognitive Function}},
  journal = {Molecular neurobiology},
  year    = {2021},
  doi     = {10.1007/s12035-020-02169-w},
  pmid    = {33098528},
  url     = {https://doi.org/10.1007/s12035-020-02169-w}
}

@article{drummond2020-32812023,
  author  = {Drummond, E. and Pires, G. and MacMurray, C. and Askenazi, M. and Nayak, S. and Bourdon, M. and Safar, J. and Ueberheide, B. and others},
  title   = {{Phosphorylated tau interactome in the human Alzheimer's disease brain}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awaa223},
  pmid    = {32812023},
  url     = {https://doi.org/10.1093/brain/awaa223}
}

@article{kirkland2020-32686219,
  author  = {Kirkland, J. L. and Tchkonia, T.},
  title   = {{Senolytic drugs: from discovery to translation}},
  journal = {Journal of internal medicine},
  year    = {2020},
  doi     = {10.1111/joim.13141},
  pmid    = {32686219},
  url     = {https://doi.org/10.1111/joim.13141}
}

@article{nadhimi2021-32814645,
  author  = {Nadhimi, Yosra and Llano, Daniel A},
  title   = {{Does hearing loss lead to dementia? A review of the literature}},
  journal = {Hearing research},
  year    = {2021},
  doi     = {10.1016/j.heares.2020.108038},
  pmid    = {32814645},
  url     = {https://doi.org/10.1016/j.heares.2020.108038}
}

@article{suire2020-32631408,
  author  = {Suire, C. N. and Abdul-Hay, S. O. and Sahara, T. and Kang, D. and Brizuela, M. K. and Saftig, P. and Dickson, D. W. and Rosenberry, T. L. and others},
  title   = {{Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00649-8},
  pmid    = {32631408},
  url     = {https://doi.org/10.1186/s13195-020-00649-8}
}

@article{xu2020-32714136,
  author  = {Xu, Y. and Zhao, M. and Han, Y. and Zhang, H.},
  title   = {{GABAergic Inhibitory Interneuron Deficits in Alzheimer's Disease: Implications for Treatment}},
  journal = {Frontiers in neuroscience},
  year    = {2020},
  doi     = {10.3389/fnins.2020.00660},
  pmid    = {32714136},
  url     = {https://doi.org/10.3389/fnins.2020.00660}
}

@article{pomeshchik2020-32589876,
  author  = {Pomeshchik, Y. and Klementieva, O. and Gil, J. and Martinsson, I. and Hansen, M. G. and de Vries, T. and Sancho-Balsells, A. and Russ, K. and others},
  title   = {{Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies}},
  journal = {Stem cell reports},
  year    = {2020},
  doi     = {10.1016/j.stemcr.2020.06.001},
  pmid    = {32589876},
  url     = {https://doi.org/10.1016/j.stemcr.2020.06.001}
}

@article{wang2020-32471464,
  author  = {Wang, W. and Zhao, F. and Ma, X. and Perry, G. and Zhu, X.},
  title   = {{Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00376-6},
  pmid    = {32471464},
  url     = {https://doi.org/10.1186/s13024-020-00376-6}
}

@article{sun2020-32093751,
  author  = {Sun, Y. and Guo, Y. and Feng, X. and Jia, M. and Ai, N. and Dong, Y. and Zheng, Y. and Fu, L. and others},
  title   = {{The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01749-w},
  pmid    = {32093751},
  url     = {https://doi.org/10.1186/s12974-020-01749-w}
}

@article{conway2020-32048098,
  author  = {Conway, M. E.},
  title   = {{Alzheimer's disease: targeting the glutamatergic system}},
  journal = {Biogerontology},
  year    = {2020},
  doi     = {10.1007/s10522-020-09860-4},
  pmid    = {32048098},
  url     = {https://doi.org/10.1007/s10522-020-09860-4}
}

@article{martinezcue2020-32116562,
  author  = {Martínez-Cué, C. and Rueda, N.},
  title   = {{Cellular Senescence in Neurodegenerative Diseases}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2020},
  doi     = {10.3389/fncel.2020.00016},
  pmid    = {32116562},
  url     = {https://doi.org/10.3389/fncel.2020.00016}
}

@article{roberts2020-32019610,
  author  = {Roberts, M. and Sevastou, I. and Imaizumi, Y. and Mistry, K. and Talma, S. and Dey, M. and Gartlon, J. and Ochiai, H. and others},
  title   = {{Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease}},
  journal = {Acta neuropathologica communications},
  year    = {2020},
  doi     = {10.1186/s40478-020-0884-2},
  pmid    = {32019610},
  url     = {https://doi.org/10.1186/s40478-020-0884-2}
}

@article{fanning2020-31909184,
  author  = {Fanning, S. and Selkoe, D. and Dettmer, U.},
  title   = {{Parkinson's disease: proteinopathy or lipidopathy?}},
  journal = {NPJ Parkinson's disease},
  year    = {2020},
  doi     = {10.1038/s41531-019-0103-7},
  pmid    = {31909184},
  url     = {https://doi.org/10.1038/s41531-019-0103-7}
}

@article{moraes2021-31887357,
  author  = {Moraes, Bruno José and Coelho, Patrícia and Fão, Lígia and Ferreira, Ildete Luísa and Rego, A Cristina},
  title   = {{Modified Glutamatergic Postsynapse in Neurodegenerative Disorders}},
  journal = {Neuroscience},
  year    = {2021},
  doi     = {10.1016/j.neuroscience.2019.12.002},
  pmid    = {31887357},
  url     = {https://doi.org/10.1016/j.neuroscience.2019.12.002}
}

@article{armiento2020-31529602,
  author  = {Armiento, V. and Spanopoulou, A. and Kapurniotu, A.},
  title   = {{Peptide-Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2020},
  doi     = {10.1002/anie.201906908},
  pmid    = {31529602},
  url     = {https://doi.org/10.1002/anie.201906908}
}

@article{pendin2021-31606858,
  author  = {Pendin, Diana and Fasolato, Cristina and Basso, Emy and Filadi, Riccardo and Greotti, Elisa and Galla, Luisa and Gomiero, Chiara and Leparulo, Alessandro and others},
  title   = {{Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability}},
  journal = {Aging clinical and experimental research},
  year    = {2021},
  doi     = {10.1007/s40520-019-01341-0},
  pmid    = {31606858},
  url     = {https://doi.org/10.1007/s40520-019-01341-0}
}

@article{fecher2019-31501572,
  author  = {Fecher, C. and Trovò, L. and Müller, S. A. and Snaidero, N. and Wettmarshausen, J. and Heink, S. and Ortiz, O. and Wagner, I. and others},
  title   = {{Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0479-z},
  pmid    = {31501572},
  url     = {https://doi.org/10.1038/s41593-019-0479-z}
}

@article{perov2019-31469892,
  author  = {Perov, S. and Lidor, O. and Salinas, N. and Golan, N. and Tayeb-Fligelman, E. and Deshmukh, M. and Willbold, D. and Landau, M.},
  title   = {{Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents}},
  journal = {PLoS pathogens},
  year    = {2019},
  doi     = {10.1371/journal.ppat.1007978},
  pmid    = {31469892},
  url     = {https://doi.org/10.1371/journal.ppat.1007978}
}

@article{sonawane2019-31460408,
  author  = {Sonawane, S. K. and Ahmad, A. and Chinnathambi, S.},
  title   = {{Protein-Capped Metal Nanoparticles Inhibit Tau Aggregation in Alzheimer's Disease}},
  journal = {ACS omega},
  year    = {2019},
  doi     = {10.1021/acsomega.9b01411},
  pmid    = {31460408},
  url     = {https://doi.org/10.1021/acsomega.9b01411}
}

@article{meade2019-31331359,
  author  = {Meade, R. M. and Fairlie, D. P. and Mason, J. M.},
  title   = {{Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0329-1},
  pmid    = {31331359},
  url     = {https://doi.org/10.1186/s13024-019-0329-1}
}

@article{kroth2019-31264169,
  author  = {Kroth, H. and Oden, F. and Molette, J. and Schieferstein, H. and Capotosti, F. and Mueller, A. and Berndt, M. and Schmitt-Willich, H. and others},
  title   = {{Discovery and preclinical characterization of [ 18 F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2019},
  doi     = {10.1007/s00259-019-04397-2},
  pmid    = {31264169},
  url     = {https://doi.org/10.1007/s00259-019-04397-2}
}

@article{janowicz2019-31239479,
  author  = {Janowicz, P. W. and Leinenga, G. and Götz, J. and Nisbet, R. M.},
  title   = {{Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-45577-2},
  pmid    = {31239479},
  url     = {https://doi.org/10.1038/s41598-019-45577-2}
}

@article{zheng2019-31234523,
  author  = {Zheng, Q. and Kebede, M. T. and Kemeh, M. M. and Islam, S. and Lee, B. and Bleck, S. D. and Wurfl, L. A. and Lazo, N. D.},
  title   = {{Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2019},
  doi     = {10.3390/molecules24122316},
  pmid    = {31234523},
  url     = {https://doi.org/10.3390/molecules24122316}
}

@article{riboldi2019-31010158,
  author  = {Riboldi, G. M. and Di Fonzo, A. B.},
  title   = {{GBA , Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches}},
  journal = {Cells},
  year    = {2019},
  doi     = {10.3390/cells8040364},
  pmid    = {31010158},
  url     = {https://doi.org/10.3390/cells8040364}
}

@article{scoles2019-31119194,
  author  = {Scoles, D. R. and Minikel, E. V. and Pulst, S. M.},
  title   = {{Antisense oligonucleotides: A primer}},
  journal = {Neurology. Genetics},
  year    = {2019},
  doi     = {10.1212/nxg.0000000000000323},
  pmid    = {31119194},
  url     = {https://doi.org/10.1212/nxg.0000000000000323}
}

@article{maia2019-30893882,
  author  = {Maia, M. A. and Sousa, E.},
  title   = {{BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2019},
  doi     = {10.3390/ph12010041},
  pmid    = {30893882},
  url     = {https://doi.org/10.3390/ph12010041}
}

@article{mondal2019-30844238,
  author  = {Mondal, Santanu and Thompson, Paul R.},
  title   = {{Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination}},
  journal = {Accounts of Chemical Research},
  year    = {2019},
  doi     = {10.1021/acs.accounts.9b00024},
  pmid    = {30844238},
  url     = {https://doi.org/10.1021/acs.accounts.9b00024}
}

@article{fang2019-30742114,
  author  = {Fang, E. F. and Hou, Y. and Palikaras, K. and Adriaanse, B. A. and Kerr, J. S. and Yang, B. and Lautrup, S. and Hasan-Olive, M. M. and others},
  title   = {{Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-018-0332-9},
  pmid    = {30742114},
  url     = {https://doi.org/10.1038/s41593-018-0332-9}
}

@article{liu2019-30800052,
  author  = {Liu, J. and Chang, L. and Song, Y. and Li, H. and Wu, Y.},
  title   = {{The Role of NMDA Receptors in Alzheimer's Disease}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.00043},
  pmid    = {30800052},
  url     = {https://doi.org/10.3389/fnins.2019.00043}
}

@article{dominy2019-30746447,
  author  = {Dominy, S. S. and Lynch, C. and Ermini, F. and Benedyk, M. and Marczyk, A. and Konradi, A. and Nguyen, M. and Haditsch, U. and others},
  title   = {{Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors}},
  journal = {Science advances},
  year    = {2019},
  doi     = {10.1126/sciadv.aau3333},
  pmid    = {30746447},
  url     = {https://doi.org/10.1126/sciadv.aau3333}
}

@article{liu2019-30626721,
  author  = {Liu, L. and Ding, L. and Rovere, M. and Wolfe, M. S. and Selkoe, D. J.},
  title   = {{A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor}},
  journal = {The Journal of cell biology},
  year    = {2019},
  doi     = {10.1083/jcb.201806205},
  pmid    = {30626721},
  url     = {https://doi.org/10.1083/jcb.201806205}
}

@article{lleo2019-30606734,
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  year    = {2019},
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@article{pradier2018-30486882,
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  title   = {{SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0447-y},
  pmid    = {30486882},
  url     = {https://doi.org/10.1186/s13195-018-0447-y}
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@article{fan2018-30107760,
  author  = {Fan, S. and Zheng, Y. and Liu, X. and Fang, W. and Chen, X. and Liao, W. and Jing, X. and Lei, M. and others},
  title   = {{Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease}},
  journal = {Drug delivery},
  year    = {2018},
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  pmid    = {30107760},
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@article{musi2018-30126037,
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  title   = {{Tau protein aggregation is associated with cellular senescence in the brain}},
  journal = {Aging cell},
  year    = {2018},
  doi     = {10.1111/acel.12840},
  pmid    = {30126037},
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@article{gonzalez2018-30171212,
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  title   = {{Modeling amyloid beta and tau pathology in human cerebral organoids}},
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@article{okamoto2018-30108205,
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  title   = {{Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease}},
  journal = {Translational psychiatry},
  year    = {2018},
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@article{sakakibara2018-30055565,
  author  = {Sakakibara, Y. and Sekiya, M. and Saito, T. and Saido, T. C. and Iijima, K. M.},
  title   = {{Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis}},
  journal = {BMC neuroscience},
  year    = {2018},
  doi     = {10.1186/s12868-018-0446-8},
  pmid    = {30055565},
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@article{shen2018-29937713,
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  title   = {{Cognitive Decline, Dementia, Alzheimer's Disease and Presbycusis: Examination of the Possible Molecular Mechanism}},
  journal = {Frontiers in neuroscience},
  year    = {2018},
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@article{maiti2018-29857538,
  author  = {Maiti, P. and Dunbar, G. L.},
  title   = {{Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms19061637},
  pmid    = {29857538},
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}

@article{velazquez2018-29749079,
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  title   = {{Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits}},
  journal = {Aging cell},
  year    = {2018},
  doi     = {10.1111/acel.12775},
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}

@article{arndt2018-29686315,
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  title   = {{Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β}},
  journal = {Scientific reports},
  year    = {2018},
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}

@article{shah2018-29674739,
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  title   = {{Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP NL-F/NL-F knock-in mice}},
  journal = {Scientific reports},
  year    = {2018},
  doi     = {10.1038/s41598-018-24657-9},
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}

@article{chen2018-29722330,
  author  = {Chen, M. and Du, Z. Y. and Zheng, X. and Li, D. L. and Zhou, R. P. and Zhang, K.},
  title   = {{Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease}},
  journal = {Neural regeneration research},
  year    = {2018},
  doi     = {10.4103/1673-5374.230303},
  pmid    = {29722330},
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}

@article{sanchezlopez2018-29587747,
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  title   = {{Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization}},
  journal = {Journal of Nanobiotechnology},
  year    = {2018},
  doi     = {10.1186/s12951-018-0356-z},
  pmid    = {29587747},
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}

@article{nguyen2018-29511098,
  author  = {Nguyen, A. D. and Nguyen, T. A. and Zhang, J. and Devireddy, S. and Zhou, P. and Karydas, A. M. and Xu, X. and Miller, B. L. and others},
  title   = {{Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2018},
  doi     = {10.1073/pnas.1722344115},
  pmid    = {29511098},
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}

@article{luna2018-29502200,
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  title   = {{Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity}},
  journal = {Acta neuropathologica},
  year    = {2018},
  doi     = {10.1007/s00401-018-1829-8},
  pmid    = {29502200},
  url     = {https://doi.org/10.1007/s00401-018-1829-8}
}

@article{evans2018-29590627,
  author  = {Evans, L. D. and Wassmer, T. and Fraser, G. and Smith, J. and Perkinton, M. and Billinton, A. and Livesey, F. J.},
  title   = {{Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways}},
  journal = {Cell reports},
  year    = {2018},
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  pmid    = {29590627},
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}

@article{dai2018-29386065,
  author  = {Dai, C. L. and Hu, W. and Tung, Y. C. and Liu, F. and Gong, C. X. and Iqbal, K.},
  title   = {{Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0341-7},
  pmid    = {29386065},
  url     = {https://doi.org/10.1186/s13195-018-0341-7}
}

@article{folch2018-29254093,
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  title   = {{Memantine for the Treatment of Dementia: A Review on its Current and Future Applications}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-170672},
  pmid    = {29254093},
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@article{cline2018-29843241,
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  title   = {{The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
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}

@article{swerdlow2018-29036828,
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  title   = {{Mitochondria and Mitochondrial Cascades in Alzheimer's Disease}},
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  year    = {2018},
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@article{klaips2018-29127110,
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  year    = {2018},
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  title   = {{CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons}},
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  year    = {2017},
  doi     = {10.1186/s40478-017-0475-z},
  pmid    = {29078805},
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@article{cheignon2018-29080524,
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  title   = {{Oxidative stress and the amyloid beta peptide in Alzheimer's disease}},
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  year    = {2018},
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  pmid    = {29080524},
  url     = {https://doi.org/10.1016/j.redox.2017.10.014}
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@article{vandyck2018-28967385,
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  title   = {{Anti-Amyloid-β Monoclonal Antibodies for Alzheimer's Disease: Pitfalls and Promise}},
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  year    = {2018},
  doi     = {10.1016/j.biopsych.2017.08.010},
  pmid    = {28967385},
  url     = {https://doi.org/10.1016/j.biopsych.2017.08.010}
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@article{sasaguri2017-28768718,
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  title   = {{APP mouse models for Alzheimer's disease preclinical studies}},
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  year    = {2017},
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  pmid    = {28768718},
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@article{boxer2017-28653647,
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  title   = {{Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches}},
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  year    = {2017},
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@article{querolvilaseca2017-28599675,
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  title   = {{YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies}},
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@article{miyamoto2017-28526038,
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  title   = {{Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0176-x},
  pmid    = {28526038},
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@article{jones2017-28333144,
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  title   = {{Aberrant iPSC-derived human astrocytes in Alzheimer's disease}},
  journal = {Cell Death and Disease},
  year    = {2017},
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@article{trzeciakiewicz2017-28287136,
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  title   = {{A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy}},
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  year    = {2017},
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@article{cacabelos2017-28273839,
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  journal = {International journal of molecular sciences},
  year    = {2017},
  doi     = {10.3390/ijms18030551},
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  title   = {{Tau PET imaging: present and future directions}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
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  title   = {{Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer's Disease}},
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  year    = {2017},
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  pmid    = {28208831},
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  title   = {{Loss-of-function mutations in the ATP13A2/PARK9 gene cause complicated hereditary spastic paraplegia (SPG78)}},
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  year    = {2017},
  doi     = {10.1093/brain/aww307},
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@article{dai2017-28073379,
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  title   = {{Tau passive immunization inhibits not only tau but also Aβ pathology}},
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  year    = {2017},
  doi     = {10.1186/s13195-016-0227-5},
  pmid    = {28073379},
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@article{study2017-28061328,
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  year    = {2017},
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  year    = {2017},
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  title   = {{Autophagy and heat-shock response impair stress granule assembly during cellular senescence}},
  journal = {Mechanisms of ageing and development},
  year    = {2020},
  doi     = {10.1016/j.mad.2020.111382},
  pmid    = {33049246},
  url     = {https://doi.org/10.1016/j.mad.2020.111382}
}

@article{latifhernandez2020-32838792,
  author  = {Latif-Hernandez, Amira and Sabanov, Victor and Ahmed, Tariq and Craessaerts, Katleen and Saito, Takashi and Saido, Takaomi and Balschun, Detlef},
  title   = {{The two faces of synaptic failure in AppNL-G-F knock-in mice}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00667-6},
  pmid    = {32838792},
  url     = {https://doi.org/10.1186/s13195-020-00667-6}
}

@article{xie2020-32717200,
  author  = {Xie, Zhuoya and Wu, Hongrong and Zhao, Jianfeng},
  title   = {{Multifunctional roles of zinc in Alzheimer's disease}},
  journal = {Neurotoxicology},
  year    = {2020},
  doi     = {10.1016/j.neuro.2020.07.003},
  pmid    = {32717200},
  url     = {https://doi.org/10.1016/j.neuro.2020.07.003}
}

@article{almeida2020-32739009,
  author  = {Almeida, Michael F and Bahr, Ben A and Kinsey, Stephen T},
  title   = {{Endosomal-lysosomal dysfunction in metabolic diseases and Alzheimer's disease}},
  journal = {International review of neurobiology},
  year    = {2020},
  doi     = {10.1016/bs.irn.2020.02.012},
  pmid    = {32739009},
  url     = {https://doi.org/10.1016/bs.irn.2020.02.012}
}

@article{ntim2020-32219328,
  author  = {Ntim, Michael and Li, Qi-Fa and Zhang, Yue and Liu, Xiao-Da and Li, Na and Sun, Hai-Lun and Zhang, Xuan and Khan, Bakhtawar and others},
  title   = {{TRIM32 Deficiency Impairs Synaptic Plasticity by Excitatory-Inhibitory Imbalance via Notch Pathway}},
  journal = {Cerebral cortex (New York, N.Y. : 1991)},
  year    = {2020},
  doi     = {10.1093/cercor/bhaa064},
  pmid    = {32219328},
  url     = {https://doi.org/10.1093/cercor/bhaa064}
}

@article{shen2020-32531261,
  author  = {Shen, Linjing and Wang, Changliang and Chen, Liang and Leung, Ka Lai and Lo, Esther and Lakso, Merja and Wong, Garry},
  title   = {{TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans}},
  journal = {Biochimica et biophysica acta. Molecular basis of disease},
  year    = {2020},
  doi     = {10.1016/j.bbadis.2020.165876},
  pmid    = {32531261},
  url     = {https://doi.org/10.1016/j.bbadis.2020.165876}
}

@article{chavezgutierrez2020-32418657,
  author  = {Chávez-Gutiérrez, Lucía and Szaruga, Maria},
  title   = {{Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease}},
  journal = {Seminars in cell \& developmental biology},
  year    = {2020},
  doi     = {10.1016/j.semcdb.2020.03.005},
  pmid    = {32418657},
  url     = {https://doi.org/10.1016/j.semcdb.2020.03.005}
}

@article{rezazaldivar2020-32432108,
  author  = {Reza-Zaldivar, Edwin Estefan and Hernández-Sápiens, Mercedes Azucena and Minjarez, Benito and Gómez-Pinedo, Ulises and Sánchez-González, Victor Javier and Márquez-Aguirre, Ana Laura and Canales-Aguirre, Alejandro Arturo},
  title   = {{Dendritic Spine and Synaptic Plasticity in Alzheimer's Disease: A Focus on MicroRNA}},
  journal = {Frontiers in cell and developmental biology},
  year    = {2020},
  doi     = {10.3389/fcell.2020.00255},
  pmid    = {32432108},
  url     = {https://doi.org/10.3389/fcell.2020.00255}
}

@article{iwasaki2020-32363728,
  author  = {Iwasaki, Yasushi},
  title   = {{The Braak hypothesis in prion disease with a focus on Creutzfeldt-Jakob disease}},
  journal = {Neuropathology : official journal of the Japanese Society of Neuropathology},
  year    = {2020},
  doi     = {10.1111/neup.12654},
  pmid    = {32363728},
  url     = {https://doi.org/10.1111/neup.12654}
}

@article{torres2020-32250284,
  author  = {Torres, Diana Marcela Cuestas and Cardenas, Fernando P},
  title   = {{Synaptic plasticity in Alzheimer's disease and healthy aging}},
  journal = {Reviews in the neurosciences},
  year    = {2020},
  doi     = {10.1515/revneuro-2019-0058},
  pmid    = {32250284},
  url     = {https://doi.org/10.1515/revneuro-2019-0058}
}

@article{weidling2020-32339611,
  author  = {Weidling, Ian W and Swerdlow, Russell H},
  title   = {{Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis}},
  journal = {Experimental neurology},
  year    = {2020},
  doi     = {10.1016/j.expneurol.2020.113321},
  pmid    = {32339611},
  url     = {https://doi.org/10.1016/j.expneurol.2020.113321}
}

@article{dargenio2020-32325882,
  author  = {D'Argenio, Valeria and Sarnataro, Daniela},
  title   = {{New Insights into the Molecular Bases of Familial Alzheimer's Disease}},
  journal = {Journal of personalized medicine},
  year    = {2020},
  doi     = {10.3390/jpm10020026},
  pmid    = {32325882},
  url     = {https://doi.org/10.3390/jpm10020026}
}

@article{guisle2020-31702011,
  author  = {Guisle, Isabelle and Gratuze, Maud and Petry, Séréna and Morin, Françoise and Keraudren, Rémi and Whittington, Robert A and Hébert, Sébastien S and Mongrain, Valérie and others},
  title   = {{Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature}},
  journal = {Sleep},
  year    = {2020},
  doi     = {10.1093/sleep/zsz266},
  pmid    = {31702011},
  url     = {https://doi.org/10.1093/sleep/zsz266}
}

@article{hohn2020-32308803,
  author  = {Höhn, Annika and Tramutola, Antonella and Cascella, Roberta},
  title   = {{Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2020},
  doi     = {10.1155/2020/5497046},
  pmid    = {32308803},
  url     = {https://doi.org/10.1155/2020/5497046}
}

@article{mehra2020-31971183,
  author  = {Mehra, Rukmankesh and Dehury, Budheswar and Kepp, Kasper P},
  title   = {{Cryo-temperature effects on membrane protein structure and dynamics}},
  journal = {Physical chemistry chemical physics : PCCP},
  year    = {2020},
  doi     = {10.1039/c9cp06723j},
  pmid    = {31971183},
  url     = {https://doi.org/10.1039/c9cp06723j}
}

@article{cai2020-31791115,
  author  = {Cai, Mudan and Jung, Inho and Kwon, Huiyoung and Cho, Eunbi and Jeon, Jieun and Yun, Jeanho and Lee, Young Choon and Kim, Dong Hyun and others},
  title   = {{Spinosin Attenuates Alzheimer's Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity}},
  journal = {Biomolecules \& therapeutics},
  year    = {2020},
  doi     = {10.4062/biomolther.2019.076},
  pmid    = {31791115},
  url     = {https://doi.org/10.4062/biomolther.2019.076}
}

@article{huang2020-32180703,
  author  = {Huang, Wendi and Zhou, Yongjian and Tu, Lin and Ba, Zhisheng and Huang, Juan and Huang, Nanqu and Luo, Yong},
  title   = {{TDP-43: From Alzheimer's Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2020},
  doi     = {10.3389/fnmol.2020.00026},
  pmid    = {32180703},
  url     = {https://doi.org/10.3389/fnmol.2020.00026}
}

@article{cifelli2020-31943943,
  author  = {Cifelli, Jessica L and Berg, Kyle R and Yang, Jerry},
  title   = {{Benzothiazole amphiphiles promote RasGRF1-associated dendritic spine formation in human stem cell-derived neurons}},
  journal = {FEBS open bio},
  year    = {2020},
  doi     = {10.1002/2211-5463.12788},
  pmid    = {31943943},
  url     = {https://doi.org/10.1002/2211-5463.12788}
}

@article{pelucchi2020-32019166,
  author  = {Pelucchi, Silvia and Stringhi, Ramona and Marcello, Elena},
  title   = {{Dendritic Spines in Alzheimer's Disease: How the Actin Cytoskeleton Contributes to Synaptic Failure}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21030908},
  pmid    = {32019166},
  url     = {https://doi.org/10.3390/ijms21030908}
}

@article{llanosgonzalez2019-32063825,
  author  = {Llanos-González, Emilio and Henares-Chavarino, Ángel Andres and Pedrero-Prieto, Cristina María and García-Carpintero, Sonia and Frontiñán-Rubio, Javier and Sancho-Bielsa, Francisco Javier and Alcain, Francisco Javier and Peinado, Juan Ramón and others},
  title   = {{Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer's Disease}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.01444},
  pmid    = {32063825},
  url     = {https://doi.org/10.3389/fnins.2019.01444}
}

@article{galla2020-31991578,
  author  = {Galla, Luisa and Redolfi, Nelly and Pozzan, Tullio and Pizzo, Paola and Greotti, Elisa},
  title   = {{Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21030770},
  pmid    = {31991578},
  url     = {https://doi.org/10.3390/ijms21030770}
}

@article{bharadwaj2020-31962153,
  author  = {Bharadwaj, Prashant R and Martins, Ralph N},
  title   = {{Autophagy modulates Aβ accumulation and formation of aggregates in yeast}},
  journal = {Molecular and cellular neurosciences},
  year    = {2020},
  doi     = {10.1016/j.mcn.2020.103466},
  pmid    = {31962153},
  url     = {https://doi.org/10.1016/j.mcn.2020.103466}
}

@article{gharibyan2020-31947546,
  author  = {Gharibyan, Anna L and Islam, Tohidul and Pettersson, Nina and Golchin, Solmaz A and Lundgren, Johanna and Johansson, Gabriella and Genot, Mélany and Schultz, Nina and others},
  title   = {{Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity}},
  journal = {Biomolecules},
  year    = {2020},
  doi     = {10.3390/biom10010134},
  pmid    = {31947546},
  url     = {https://doi.org/10.3390/biom10010134}
}

@article{lin2019-31992982,
  author  = {Lin, Yan and Rajamohamedsait, Hameetha B and Sandusky-Beltran, Leslie A and Gamallo-Lana, Begona and Mar, Adam and Sigurdsson, Einar M},
  title   = {{Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model}},
  journal = {Frontiers in aging neuroscience},
  year    = {2019},
  doi     = {10.3389/fnagi.2019.00377},
  pmid    = {31992982},
  url     = {https://doi.org/10.3389/fnagi.2019.00377}
}

@article{zhang2019-31992981,
  author  = {Zhang, Lumi and Chen, Yi and Liu, Min and Wang, Yunyun and Peng, Guoping},
  title   = {{TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy}},
  journal = {Frontiers in aging neuroscience},
  year    = {2019},
  doi     = {10.3389/fnagi.2019.00376},
  pmid    = {31992981},
  url     = {https://doi.org/10.3389/fnagi.2019.00376}
}

@article{deaton2020-32804090,
  author  = {Deaton, Carol A and Johnson, Gail V W},
  title   = {{Presenilin 1 Regulates Membrane Homeostatic Pathways that are Dysregulated in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200598},
  pmid    = {32804090},
  url     = {https://doi.org/10.3233/jad-200598}
}

@article{sathyaprakash2020-32865792,
  author  = {Sathyaprakash, Chaitra and Manzano, Raquel and Varela, Miguel A and Hashimoto, Yasumasa and Wood, Matthew J A and Talbot, Kevin and Aoki, Yoshitsugu},
  title   = {{Development of LNA Gapmer Oligonucleotide-Based Therapy for ALS/FTD Caused by the C9orf72 Repeat Expansion}},
  journal = {Methods in molecular biology (Clifton, N.J.)},
  year    = {2020},
  doi     = {10.1007/978-1-0716-0771-8_14},
  pmid    = {32865792},
  url     = {https://doi.org/10.1007/978-1-0716-0771-8_14}
}

@article{riedel2020-32091331,
  author  = {Riedel, Gernot and Klein, Jochen and Niewiadomska, Grazyna and Kondak, Constantin and Schwab, Karima and Lauer, Dilyara and Magbagbeolu, Mandy and Steczkowska, Marta and others},
  title   = {{Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model}},
  journal = {Current Alzheimer research},
  year    = {2020},
  doi     = {10.2174/1567205017666200224120926},
  pmid    = {32091331},
  url     = {https://doi.org/10.2174/1567205017666200224120926}
}

@article{liu2020-32538849,
  author  = {Liu, Yi and Bian, Huijie and Xu, Siyi and Shu, Shu and Jia, Junqiu and Chen, Jian and Cao, Xiang and Bao, Xinyu and others},
  title   = {{Muscone Ameliorates Synaptic Dysfunction and Cognitive Deficits in APP/PS1 Mice}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200188},
  pmid    = {32538849},
  url     = {https://doi.org/10.3233/jad-200188}
}

@article{harris2020-32274758,
  author  = {Harris, Lee D and Jasem, Sarah and Licchesi, Julien D F},
  title   = {{The Ubiquitin System in Alzheimer's Disease}},
  journal = {Advances in experimental medicine and biology},
  year    = {2020},
  doi     = {10.1007/978-3-030-38266-7_8},
  pmid    = {32274758},
  url     = {https://doi.org/10.1007/978-3-030-38266-7_8}
}

@article{papanikolopoulou2020-32274757,
  author  = {Papanikolopoulou, Katerina and Skoulakis, Efthimios M C},
  title   = {{Altered Proteostasis in Neurodegenerative Tauopathies}},
  journal = {Advances in experimental medicine and biology},
  year    = {2020},
  doi     = {10.1007/978-3-030-38266-7_7},
  pmid    = {32274757},
  url     = {https://doi.org/10.1007/978-3-030-38266-7_7}
}

@article{pragati2020-31715291,
  author  = {Pragati and Chanu, Soram Idiyasan and Sarkar, Surajit},
  title   = {{Reduced expression of dMyc mitigates TauV337M mediated neurotoxicity by preventing the Tau hyperphosphorylation and inducing autophagy in Drosophila}},
  journal = {Neuroscience letters},
  year    = {2020},
  doi     = {10.1016/j.neulet.2019.134622},
  pmid    = {31715291},
  url     = {https://doi.org/10.1016/j.neulet.2019.134622}
}

@article{aathi2019-31831959,
  author  = {Aathi, Muthusankar and Piramanayagam, Shanmughavel},
  title   = {{From EST to structure models for functional inference of APP, BACE1, PSEN1, PSEN2 genes}},
  journal = {Bioinformation},
  year    = {2019},
  doi     = {10.6026/97320630015760},
  pmid    = {31831959},
  url     = {https://doi.org/10.6026/97320630015760}
}

@article{hwang2019-31634675,
  author  = {Hwang, Jee-Yeon and Yan, Jingqi and Zukin, Ruth Suzanne},
  title   = {{Autophagy and synaptic plasticity: epigenetic regulation}},
  journal = {Current opinion in neurobiology},
  year    = {2019},
  doi     = {10.1016/j.conb.2019.09.010},
  pmid    = {31634675},
  url     = {https://doi.org/10.1016/j.conb.2019.09.010}
}

@article{jiang2019-31667754,
  author  = {Jiang, Jie and Ravits, John},
  title   = {{Pathogenic Mechanisms and Therapy Development for C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2019},
  doi     = {10.1007/s13311-019-00797-2},
  pmid    = {31667754},
  url     = {https://doi.org/10.1007/s13311-019-00797-2}
}

@article{chung2019-31556259,
  author  = {Chung, Hyun Kyung and Ho, Hoang-Anh and Pérez-Acuña, Dayana and Lee, Seung-Jae},
  title   = {{Modeling α-Synuclein Propagation with Preformed Fibril Injections}},
  journal = {Journal of movement disorders},
  year    = {2019},
  doi     = {10.14802/jmd.19046},
  pmid    = {31556259},
  url     = {https://doi.org/10.14802/jmd.19046}
}

@article{dargenio2019-31547531,
  author  = {D'Argenio, Valeria and Sarnataro, Daniela},
  title   = {{Microbiome Influence in the Pathogenesis of Prion and Alzheimer's Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2019},
  doi     = {10.3390/ijms20194704},
  pmid    = {31547531},
  url     = {https://doi.org/10.3390/ijms20194704}
}

@article{fliessbach2019-31332452,
  author  = {Fließbach, Klaus and McCormick, Cornelia and Kaulen, Barbara and Schneider, Anja},
  title   = {{[Anti-tau therapies-what can be expected?]}},
  journal = {Der Nervenarzt},
  year    = {2019},
  doi     = {10.1007/s00115-019-0758-7},
  pmid    = {31332452},
  url     = {https://doi.org/10.1007/s00115-019-0758-7}
}

@article{bitan2019-31699321,
  author  = {Bitan, Gal},
  title   = {{Disease-modifying therapy for proteinopathies: Can the exception become the rule?}},
  journal = {Progress in molecular biology and translational science},
  year    = {2019},
  doi     = {10.1016/bs.pmbts.2019.07.010},
  pmid    = {31699321},
  url     = {https://doi.org/10.1016/bs.pmbts.2019.07.010}
}

@article{drake2019-31339297,
  author  = {Drake, Lindsey R and Pham, Jonathan M and Desmond, Timothy J and Mossine, Andrew V and Lee, So Jeong and Kilbourn, Michael R and Koeppe, Robert A and Brooks, Allen F and others},
  title   = {{Identification of AV-1451 as a Weak, Nonselective Inhibitor of Monoamine Oxidase}},
  journal = {ACS chemical neuroscience},
  year    = {2019},
  doi     = {10.1021/acschemneuro.9b00326},
  pmid    = {31339297},
  url     = {https://doi.org/10.1021/acschemneuro.9b00326}
}

@article{pulst2019-31165208,
  author  = {Pulst, Stefan-M},
  title   = {{[Antisense therapies for neurological diseases]}},
  journal = {Der Nervenarzt},
  year    = {2019},
  doi     = {10.1007/s00115-019-0724-4},
  pmid    = {31165208},
  url     = {https://doi.org/10.1007/s00115-019-0724-4}
}

@article{mango2019-31379566,
  author  = {Mango, Dalila and Saidi, Amira and Cisale, Giusy Ylenia and Feligioni, Marco and Corbo, Massimo and Nisticò, Robert},
  title   = {{Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease}},
  journal = {Frontiers in pharmacology},
  year    = {2019},
  doi     = {10.3389/fphar.2019.00778},
  pmid    = {31379566},
  url     = {https://doi.org/10.3389/fphar.2019.00778}
}

@article{wolfe2019-31699328,
  author  = {Wolfe, Michael S},
  title   = {{In search of pathogenic amyloid β-peptide in familial Alzheimer's disease}},
  journal = {Progress in molecular biology and translational science},
  year    = {2019},
  doi     = {10.1016/bs.pmbts.2019.07.002},
  pmid    = {31699328},
  url     = {https://doi.org/10.1016/bs.pmbts.2019.07.002}
}

@article{strohm2020-31132469,
  author  = {Strohm, Laura and Behrends, Christian},
  title   = {{Glia-specific autophagy dysfunction in ALS}},
  journal = {Seminars in cell \& developmental biology},
  year    = {2020},
  doi     = {10.1016/j.semcdb.2019.05.024},
  pmid    = {31132469},
  url     = {https://doi.org/10.1016/j.semcdb.2019.05.024}
}

@article{hubin2019-31058310,
  author  = {Hubin, Ellen and Verghese, Philip B and van Nuland, Nico and Broersen, Kerensa},
  title   = {{Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation}},
  journal = {FEBS letters},
  year    = {2019},
  doi     = {10.1002/1873-3468.13428},
  pmid    = {31058310},
  url     = {https://doi.org/10.1002/1873-3468.13428}
}

@article{giagkou2019-31007097,
  author  = {Giagkou, Nikolaos and Stamelou, Maria},
  title   = {{Emerging drugs for progressive supranuclear palsy}},
  journal = {Expert opinion on emerging drugs},
  year    = {2019},
  doi     = {10.1080/14728214.2019.1609450},
  pmid    = {31007097},
  url     = {https://doi.org/10.1080/14728214.2019.1609450}
}

@article{dimeco2020-31262433,
  author  = {Di Meco, Antonio and Curtis, Mary Elizabeth and Lauretti, Elisabetta and Praticò, Domenico},
  title   = {{Autophagy Dysfunction in Alzheimer's Disease: Mechanistic Insights and New Therapeutic Opportunities}},
  journal = {Biological psychiatry},
  year    = {2020},
  doi     = {10.1016/j.biopsych.2019.05.008},
  pmid    = {31262433},
  url     = {https://doi.org/10.1016/j.biopsych.2019.05.008}
}

@article{outeiro2019-31085616,
  author  = {Outeiro, Tiago Fleming and Harvey, Kirsten and Dominguez-Meijide, Antonio and Gerhardt, Ellen},
  title   = {{LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?}},
  journal = {Biochemical Society transactions},
  year    = {2019},
  doi     = {10.1042/bst20180466},
  pmid    = {31085616},
  url     = {https://doi.org/10.1042/bst20180466}
}

@article{senturk2019-31032688,
  author  = {Şentürk, Mümine and Mao, Dongxue and Bellen, Hugo J},
  title   = {{Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes}},
  journal = {Autophagy},
  year    = {2019},
  doi     = {10.1080/15548627.2019.1609863},
  pmid    = {31032688},
  url     = {https://doi.org/10.1080/15548627.2019.1609863}
}

@article{wang2019-30964647,
  author  = {Wang, Fei and Chen, Danqi and Wu, Peipei and Klein, Catherine and Jin, Chunyuan},
  title   = {{Formaldehyde, Epigenetics, and Alzheimer's Disease}},
  journal = {Chemical research in toxicology},
  year    = {2019},
  doi     = {10.1021/acs.chemrestox.9b00090},
  pmid    = {30964647},
  url     = {https://doi.org/10.1021/acs.chemrestox.9b00090}
}

@article{doria2019-31004752,
  author  = {Doria, Margaux and Nury, Thomas and Delmas, Dominique and Moreau, Thibault and Lizard, Gérard and Vejux, Anne},
  title   = {{Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model}},
  journal = {Free radical biology \& medicine},
  year    = {2019},
  doi     = {10.1016/j.freeradbiomed.2019.04.016},
  pmid    = {31004752},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2019.04.016}
}

@article{gotz2019-30926830,
  author  = {Götz, Alexander and Högel, Philipp and Silber, Mara and Chaitoglou, Iro and Luy, Burkhard and Muhle-Goll, Claudia and Scharnagl, Christina and Langosch, Dieter},
  title   = {{Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-41766-1},
  pmid    = {30926830},
  url     = {https://doi.org/10.1038/s41598-019-41766-1}
}

@article{cao2019-30890471,
  author  = {Cao, Jiqing and Zhong, Margaret B and Toro, Carlos A and Zhang, Larry and Cai, Dongming},
  title   = {{Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis}},
  journal = {Neuroscience letters},
  year    = {2019},
  doi     = {10.1016/j.neulet.2019.03.016},
  pmid    = {30890471},
  url     = {https://doi.org/10.1016/j.neulet.2019.03.016}
}

@article{oikawa2019-30823664,
  author  = {Oikawa, Naoto and Walter, Jochen},
  title   = {{Presenilins and γ-Secretase in Membrane Proteostasis}},
  journal = {Cells},
  year    = {2019},
  doi     = {10.3390/cells8030209},
  pmid    = {30823664},
  url     = {https://doi.org/10.3390/cells8030209}
}

@article{shen2019-30791980,
  author  = {Shen, Xuefeng and Liu, Junjun and Fujita, Yu and Liu, Shuyu and Maeda, Tomoji and Kikuchi, Kota and Obara, Toshiki and Takebe, Arisa and others},
  title   = {{Iron treatment inhibits Aβ42 deposition in vivo and reduces Aβ42/Aβ40 ratio}},
  journal = {Biochemical and biophysical research communications},
  year    = {2019},
  doi     = {10.1016/j.bbrc.2019.01.119},
  pmid    = {30791980},
  url     = {https://doi.org/10.1016/j.bbrc.2019.01.119}
}

@article{tripathi2019-30702852,
  author  = {Tripathi, Timir and Kalita, Parismita},
  title   = {{Synergistic Effect of Amyloid-β and Tau Disrupts Neural Circuits}},
  journal = {ACS chemical neuroscience},
  year    = {2019},
  doi     = {10.1021/acschemneuro.9b00037},
  pmid    = {30702852},
  url     = {https://doi.org/10.1021/acschemneuro.9b00037}
}

@article{chidambaram2019-30654089,
  author  = {Chidambaram, Saravana Babu and Rathipriya, A G and Bolla, Srinivasa Rao and Bhat, Abid and Ray, Bipul and Mahalakshmi, Arehally Marappa and Manivasagam, Thamilarasan and Thenmozhi, Arokiasamy Justin and others},
  title   = {{Dendritic spines: Revisiting the physiological role}},
  journal = {Progress in neuro-psychopharmacology \& biological psychiatry},
  year    = {2019},
  doi     = {10.1016/j.pnpbp.2019.01.005},
  pmid    = {30654089},
  url     = {https://doi.org/10.1016/j.pnpbp.2019.01.005}
}

@article{cummings2019-31062825,
  author  = {Cummings, J and Blennow, K and Johnson, K and Keeley, M and Bateman, R J and Molinuevo, J L and Touchon, J and Aisen, P and others},
  title   = {{Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2019},
  doi     = {10.14283/jpad.2019.14},
  pmid    = {31062825},
  url     = {https://doi.org/10.14283/jpad.2019.14}
}

@article{dong2018-30577555,
  author  = {Dong, Zhen and Cui, Hongjuan},
  title   = {{The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors}},
  journal = {Cells},
  year    = {2018},
  doi     = {10.3390/cells8010004},
  pmid    = {30577555},
  url     = {https://doi.org/10.3390/cells8010004}
}

@article{laskowska2019-30529741,
  author  = {Laskowska, Ewa and Kuczyńska-Wiśnik, Dorota and Lipińska, Barbara},
  title   = {{Proteomic analysis of protein homeostasis and aggregation}},
  journal = {Journal of proteomics},
  year    = {2019},
  doi     = {10.1016/j.jprot.2018.12.003},
  pmid    = {30529741},
  url     = {https://doi.org/10.1016/j.jprot.2018.12.003}
}

@article{salazar2019-30518596,
  author  = {Salazar, Santiago V and Cox, Timothy O and Lee, Suho and Brody, A Harrison and Chyung, Annabel S and Haas, Laura T and Strittmatter, Stephen M},
  title   = {{Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2019},
  doi     = {10.1523/jneurosci.1873-18.2018},
  pmid    = {30518596},
  url     = {https://doi.org/10.1523/jneurosci.1873-18.2018}
}

@article{silva2019-30442948,
  author  = {Silva, Joana Margarida and Rodrigues, Sara and Sampaio-Marques, Belém and Gomes, Patrícia and Neves-Carvalho, Andreia and Dioli, Chrysoula and Soares-Cunha, Carina and Mazuik, Brandon F and others},
  title   = {{Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology}},
  journal = {Cell death and differentiation},
  year    = {2019},
  doi     = {10.1038/s41418-018-0217-1},
  pmid    = {30442948},
  url     = {https://doi.org/10.1038/s41418-018-0217-1}
}

@article{salles2018-30298718,
  author  = {Salles, Geisa Nogueira and Calió, Michele Longoni and Afewerki, Samson and Pacheco-Soares, Cristina and Porcionatto, Marimelia and Hölscher, Christian and Lobo, Anderson O},
  title   = {{Prolonged Drug-Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis}},
  journal = {ACS applied materials \& interfaces},
  year    = {2018},
  doi     = {10.1021/acsami.8b12649},
  pmid    = {30298718},
  url     = {https://doi.org/10.1021/acsami.8b12649}
}

@article{devi2018-30374284,
  author  = {Devi, Shreedarshanee and Yadav, Rashmi and Chanana, Pratibha and Arya, Ranjana},
  title   = {{Fighting the Cause of Alzheimer's and GNE Myopathy}},
  journal = {Frontiers in neuroscience},
  year    = {2018},
  doi     = {10.3389/fnins.2018.00669},
  pmid    = {30374284},
  url     = {https://doi.org/10.3389/fnins.2018.00669}
}

@article{zhang2018-30273830,
  author  = {Zhang, Tao and Jiang, Xin and Xu, Min and Wang, Haifang and Sang, Xiao and Qin, Meiling and Bao, Puhua and Wang, Ruiqi and others},
  title   = {{Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats}},
  journal = {Neurobiology of aging},
  year    = {2018},
  doi     = {10.1016/j.neurobiolaging.2018.08.025},
  pmid    = {30273830},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2018.08.025}
}

@article{kurtishi2019-30182337,
  author  = {Kurtishi, Alberim and Rosen, Benjamin and Patil, Ketan S and Alves, Guido W and Møller, Simon G},
  title   = {{Cellular Proteostasis in Neurodegeneration}},
  journal = {Molecular neurobiology},
  year    = {2019},
  doi     = {10.1007/s12035-018-1334-z},
  pmid    = {30182337},
  url     = {https://doi.org/10.1007/s12035-018-1334-z}
}

@article{vitale2018-30134961,
  author  = {Vitale, Francesca and Giliberto, Luca and Ruiz, Santiago and Steslow, Kristen and Marambaud, Philippe and d'Abramo, Cristina},
  title   = {{Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice}},
  journal = {Acta neuropathologica communications},
  year    = {2018},
  doi     = {10.1186/s40478-018-0585-2},
  pmid    = {30134961},
  url     = {https://doi.org/10.1186/s40478-018-0585-2}
}

@article{cortini2018-30041064,
  author  = {Cortini, Francesca and Cantoni, Claudia and Villa, Chiara},
  title   = {{Epileptic seizures in autosomal dominant forms of Alzheimer's disease}},
  journal = {Seizure},
  year    = {2018},
  doi     = {10.1016/j.seizure.2018.07.015},
  pmid    = {30041064},
  url     = {https://doi.org/10.1016/j.seizure.2018.07.015}
}

@article{paroni2019-29978424,
  author  = {Paroni, Giulia and Panza, Francesco and De Cosmo, Salvatore and Greco, Antonio and Seripa, Davide and Mazzoccoli, Gianluigi},
  title   = {{Klotho at the Edge of Alzheimer's Disease and Senile Depression}},
  journal = {Molecular neurobiology},
  year    = {2019},
  doi     = {10.1007/s12035-018-1200-z},
  pmid    = {29978424},
  url     = {https://doi.org/10.1007/s12035-018-1200-z}
}

@article{goyal2018-29742314,
  author  = {Goyal, Deepti and Kaur, Amandeep and Goyal, Bhupesh},
  title   = {{Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease}},
  journal = {ChemMedChem},
  year    = {2018},
  doi     = {10.1002/cmdc.201800156},
  pmid    = {29742314},
  url     = {https://doi.org/10.1002/cmdc.201800156}
}

@article{opazo2018-29898386,
  author  = {Opazo, Patricio and da Silva, Silvia Viana and Carta, Mario and Breillat, Christelle and Coultrap, Steven J and Grillo-Bosch, Dolors and Sainlos, Matthieu and Coussen, Françoise and others},
  title   = {{CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity}},
  journal = {Cell reports},
  year    = {2018},
  doi     = {10.1016/j.celrep.2018.05.036},
  pmid    = {29898386},
  url     = {https://doi.org/10.1016/j.celrep.2018.05.036}
}

@article{stoffel2018-29725009,
  author  = {Stoffel, Wilhelm and Jenke, Britta and Schmidt-Soltau, Inga and Binczek, Erika and Brodesser, Susanne and Hammels, Ina},
  title   = {{SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment}},
  journal = {Cell death \& disease},
  year    = {2018},
  doi     = {10.1038/s41419-018-0560-7},
  pmid    = {29725009},
  url     = {https://doi.org/10.1038/s41419-018-0560-7}
}

@article{press2019-29580826,
  author  = {Press, Michaela and Jung, Tobias and König, Jeannette and Grune, Tilman and Höhn, Annika},
  title   = {{Protein aggregates and proteostasis in aging: Amylin and β-cell function}},
  journal = {Mechanisms of ageing and development},
  year    = {2019},
  doi     = {10.1016/j.mad.2018.03.010},
  pmid    = {29580826},
  url     = {https://doi.org/10.1016/j.mad.2018.03.010}
}

@article{stallings2018-29559586,
  author  = {Stallings, Nancy R and O'Neal, Melissa A and Hu, Jie and Kavalali, Ege T and Bezprozvanny, Ilya and Malter, James S},
  title   = {{Pin1 mediates Aβ42-induced dendritic spine loss}},
  journal = {Science signaling},
  year    = {2018},
  doi     = {10.1126/scisignal.aap8734},
  pmid    = {29559586},
  url     = {https://doi.org/10.1126/scisignal.aap8734}
}

@article{nonaka2018-28108532,
  author  = {Nonaka, Takashi and Hasegawa, Masato},
  title   = {{TDP-43 Prions}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2018},
  doi     = {10.1101/cshperspect.a024463},
  pmid    = {28108532},
  url     = {https://doi.org/10.1101/cshperspect.a024463}
}

@article{peineau2018-29425728,
  author  = {Peineau, Stéphane and Rabiant, Kevin and Pierrefiche, Olivier and Potier, Brigitte},
  title   = {{Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer's disease}},
  journal = {Pharmacological research},
  year    = {2018},
  doi     = {10.1016/j.phrs.2018.01.018},
  pmid    = {29425728},
  url     = {https://doi.org/10.1016/j.phrs.2018.01.018}
}

@article{omtri2018-29337241,
  author  = {Omtri, Rajesh S and Thompson, Kevin J and Tang, Xiaojia and Gali, Chaitanya C and Panzenboeck, Ute and Davidson, Michael W and Kalari, Krishna R and Kandimalla, Karunya K},
  title   = {{Differential Effects of Alzheimer's Disease Aβ40 and 42 on Endocytosis and Intraneuronal Trafficking}},
  journal = {Neuroscience},
  year    = {2018},
  doi     = {10.1016/j.neuroscience.2018.01.003},
  pmid    = {29337241},
  url     = {https://doi.org/10.1016/j.neuroscience.2018.01.003}
}

@article{tehran2018-29316491,
  author  = {Tehran, Domenico Azarnia and Kuijpers, Marijn and Haucke, Volker},
  title   = {{Presynaptic endocytic factors in autophagy and neurodegeneration}},
  journal = {Current opinion in neurobiology},
  year    = {2018},
  doi     = {10.1016/j.conb.2017.12.018},
  pmid    = {29316491},
  url     = {https://doi.org/10.1016/j.conb.2017.12.018}
}

@article{mochizuki2018-29305061,
  author  = {Mochizuki, Hideki and Choong, Chi-Jing and Masliah, Eliezer},
  title   = {{A refined concept: α-synuclein dysregulation disease}},
  journal = {Neurochemistry international},
  year    = {2018},
  doi     = {10.1016/j.neuint.2017.12.011},
  pmid    = {29305061},
  url     = {https://doi.org/10.1016/j.neuint.2017.12.011}
}

@article{gelman2018-29154272,
  author  = {Gelman, Simon and Palma, Jonathan and Tombaugh, Geoffrey and Ghavami, Afshin},
  title   = {{Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-170457},
  pmid    = {29154272},
  url     = {https://doi.org/10.3233/jad-170457}
}

@article{wu2017-29237931,
  author  = {Wu, Xi-Lin and Piña-Crespo, Juan and Zhang, Yun-Wu and Chen, Xiao-Chun and Xu, Hua-Xi},
  title   = {{Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease}},
  journal = {Chinese medical journal},
  year    = {2017},
  doi     = {10.4103/0366-6999.220313},
  pmid    = {29237931},
  url     = {https://doi.org/10.4103/0366-6999.220313}
}

@article{hu2017-29215043,
  author  = {Hu, Yi and Kienlen-Campard, Pascal and Tang, Tzu-Chun and Perrin, Florian and Opsomer, Rémi and Decock, Marie and Pan, Xiaoshu and Octave, Jean-Noel and others},
  title   = {{β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-17144-0},
  pmid    = {29215043},
  url     = {https://doi.org/10.1038/s41598-017-17144-0}
}

@article{shahpasand2018-29049003,
  author  = {Shahpasand, Koorosh and Shamloo, Alireza Sepehri and Nabavi, Seyed Massood and Lu, Kun Ping and Zhou, Xiao Zhen},
  title   = {{"Tau immunotherapy: Hopes and hindrances"}},
  journal = {Human vaccines \& immunotherapeutics},
  year    = {2018},
  doi     = {10.1080/21645515.2017.1393594},
  pmid    = {29049003},
  url     = {https://doi.org/10.1080/21645515.2017.1393594}
}

@article{spillantini2018-29119326,
  author  = {Spillantini, Maria Grazia and Goedert, Michel},
  title   = {{Neurodegeneration and the ordered assembly of α-synuclein}},
  journal = {Cell and tissue research},
  year    = {2018},
  doi     = {10.1007/s00441-017-2706-9},
  pmid    = {29119326},
  url     = {https://doi.org/10.1007/s00441-017-2706-9}
}

@article{comerota2017-29118388,
  author  = {Comerota, Michele M and Krishnan, Balaji and Taglialatela, Giulio},
  title   = {{Near infrared light decreases synaptic vulnerability to amyloid beta oligomers}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-15357-x},
  pmid    = {29118388},
  url     = {https://doi.org/10.1038/s41598-017-15357-x}
}

@article{penke2017-28994715,
  author  = {Penke, Botond and Bogár, Ferenc and Fülöp, Lívia},
  title   = {{β-Amyloid and the Pathomechanisms of Alzheimer's Disease: A Comprehensive View}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2017},
  doi     = {10.3390/molecules22101692},
  pmid    = {28994715},
  url     = {https://doi.org/10.3390/molecules22101692}
}

@article{feng2017-28796567,
  author  = {Feng, Yuchen and Klionsky, Daniel J},
  title   = {{Receptors make the pathway choice for protein degradation}},
  journal = {Autophagy},
  year    = {2017},
  doi     = {10.1080/15548627.2017.1356553},
  pmid    = {28796567},
  url     = {https://doi.org/10.1080/15548627.2017.1356553}
}

@article{rodolfo2018-28797885,
  author  = {Rodolfo, Carlo and Campello, Silvia and Cecconi, Francesco},
  title   = {{Mitophagy in neurodegenerative diseases}},
  journal = {Neurochemistry international},
  year    = {2018},
  doi     = {10.1016/j.neuint.2017.08.004},
  pmid    = {28797885},
  url     = {https://doi.org/10.1016/j.neuint.2017.08.004}
}

@article{palmeri2017-28626017,
  author  = {Palmeri, Agostino and Ricciarelli, Roberta and Gulisano, Walter and Rivera, Daniela and Rebosio, Claudia and Calcagno, Elisa and Tropea, Maria Rosaria and Conti, Silvia and others},
  title   = {{Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.3607-16.2017},
  pmid    = {28626017},
  url     = {https://doi.org/10.1523/jneurosci.3607-16.2017}
}

@article{fu2017-28600964,
  author  = {Fu, Amy Ky and Ip, Nancy Y},
  title   = {{Regulation of postsynaptic signaling in structural synaptic plasticity}},
  journal = {Current opinion in neurobiology},
  year    = {2017},
  doi     = {10.1016/j.conb.2017.05.016},
  pmid    = {28600964},
  url     = {https://doi.org/10.1016/j.conb.2017.05.016}
}

@article{khan2017-28490214,
  author  = {Khan, Ayesha and Corbett, Anne and Ballard, Clive},
  title   = {{Emerging amyloid and tau targeting treatments for Alzheimer's disease}},
  journal = {Expert review of neurotherapeutics},
  year    = {2017},
  doi     = {10.1080/14737175.2017.1326819},
  pmid    = {28490214},
  url     = {https://doi.org/10.1080/14737175.2017.1326819}
}

@article{devos2017-28521124,
  author  = {DeVos, Sarah L and Hyman, Bradley T},
  title   = {{Tau at the Crossroads between Neurotoxicity and Neuroprotection}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.05.001},
  pmid    = {28521124},
  url     = {https://doi.org/10.1016/j.neuron.2017.05.001}
}

@article{shahheydari2017-28539871,
  author  = {Shahheydari, Hamideh and Ragagnin, Audrey and Walker, Adam K and Toth, Reka P and Vidal, Marta and Jagaraj, Cyril J and Perri, Emma R and Konopka, Anna and others},
  title   = {{Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2017},
  doi     = {10.3389/fnmol.2017.00119},
  pmid    = {28539871},
  url     = {https://doi.org/10.3389/fnmol.2017.00119}
}

@article{kolb2017-27940517,
  author  = {Kolb, Hartmuth C and Andrés, José Ignacio},
  title   = {{Tau Positron Emission Tomography Imaging}},
  journal = {Cold Spring Harbor perspectives in biology},
  year    = {2017},
  doi     = {10.1101/cshperspect.a023721},
  pmid    = {27940517},
  url     = {https://doi.org/10.1101/cshperspect.a023721}
}

@article{galasko2017-28410662,
  author  = {Galasko, Douglas},
  title   = {{Lewy Body Disorders}},
  journal = {Neurologic clinics},
  year    = {2017},
  doi     = {10.1016/j.ncl.2017.01.004},
  pmid    = {28410662},
  url     = {https://doi.org/10.1016/j.ncl.2017.01.004}
}

@article{li2018-28456942,
  author  = {Li, Ke and Wei, Qing and Liu, Fang-Fang and Hu, Fan and Xie, Ao-Ji and Zhu, Ling-Qiang and Liu, Dan},
  title   = {{Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations}},
  journal = {Molecular neurobiology},
  year    = {2018},
  doi     = {10.1007/s12035-017-0533-3},
  pmid    = {28456942},
  url     = {https://doi.org/10.1007/s12035-017-0533-3}
}

@article{shabani2017-28389207,
  author  = {Shabani, Mohammad and Haghani, Masoud and Tazangi, Parisa Esmaeili and Bayat, Mahnaz and Moosavi, Seyed Mostafa Shid and Ranjbar, Hoda},
  title   = {{Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity}},
  journal = {Brain research bulletin},
  year    = {2017},
  doi     = {10.1016/j.brainresbull.2017.03.015},
  pmid    = {28389207},
  url     = {https://doi.org/10.1016/j.brainresbull.2017.03.015}
}

@article{bragoszewski2017-28446709,
  author  = {Bragoszewski, Piotr and Turek, Michal and Chacinska, Agnieszka},
  title   = {{Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system}},
  journal = {Open biology},
  year    = {2017},
  doi     = {10.1098/rsob.170007},
  pmid    = {28446709},
  url     = {https://doi.org/10.1098/rsob.170007}
}

@article{jackson2017-28355559,
  author  = {Jackson, Johanna S and Witton, Jonathan and Johnson, James D and Ahmed, Zeshan and Ward, Mark and Randall, Andrew D and Hutton, Michael L and Isaac, John T and others},
  title   = {{Altered Synapse Stability in the Early Stages of Tauopathy}},
  journal = {Cell reports},
  year    = {2017},
  doi     = {10.1016/j.celrep.2017.03.013},
  pmid    = {28355559},
  url     = {https://doi.org/10.1016/j.celrep.2017.03.013}
}

@article{wang2017-28351972,
  author  = {Wang, Bo-Jeng and Her, Guor Mour and Hu, Ming-Kuan and Chen, Yun-Wen and Tung, Ying-Tsen and Wu, Pei-Yi and Hsu, Wen-Ming and Lee, Hsinyu and others},
  title   = {{ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
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  title   = {{Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies}},
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@article{li2018-29486118,
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  title   = {{Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease}},
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  title   = {{Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis}},
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@article{chiti2017-28498720,
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@article{chen2017-28382596,
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@article{ward2017-28404863,
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  title   = {{Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis}},
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  title   = {{Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms}},
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  title   = {{Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation}},
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@article{wang2017-27662322,
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  title   = {{Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease}},
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}

@article{konno2016-26350119,
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  title   = {{Autosomal dominant Parkinson's disease caused by SNCA duplications}},
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  year    = {2016},
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@article{stratmann2016-26193084,
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  title   = {{Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology}},
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  year    = {2016},
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@article{yin2015-26143603,
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  title   = {{Sialic acid (SA)-modified selenium nanoparticles coated with a high blood-brain barrier permeability peptide-B6 peptide for potential use in Alzheimer's disease}},
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@article{funk2015-26126828,
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  title   = {{Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake}},
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  year    = {2015},
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@article{baborie2015-60de3efb,
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  title   = {{Accumulation of dipeptide repeat proteins predates that of TDP ‐43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene}},
  journal = {Neuropathology and Applied Neurobiology},
  year    = {2015},
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@article{pedersen2015-25846560,
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  title   = {{Tau immunotherapy for Alzheimer's disease}},
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  year    = {2015},
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@article{rudy2015-25821641,
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  title   = {{The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease}},
  journal = {Aging and disease},
  year    = {2015},
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}

@article{xia2015-25741723,
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  title   = {{Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease}},
  journal = {Neuron},
  year    = {2015},
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  pmid    = {25741723},
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}

@article{castillocarranza2015-25810517,
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  title   = {{Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.4989-14.2015},
  pmid    = {25810517},
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@article{rotman2015-25668771,
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  title   = {{Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease}},
  journal = {Journal of controlled release : official journal of the Controlled Release Society},
  year    = {2015},
  doi     = {10.1016/j.jconrel.2015.02.012},
  pmid    = {25668771},
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@article{whitehouse2015-2cd2e5f3,
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  title   = {{Histone deacetylases (HDACs) in frontotemporal lobar degeneration}},
  journal = {Neuropathology and Applied Neurobiology},
  year    = {2015},
  doi     = {10.1111/nan.12153},
  url     = {https://doi.org/10.1111/nan.12153}
}

@article{sengupta2015-25676491,
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  title   = {{Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies}},
  journal = {Biological psychiatry},
  year    = {2015},
  doi     = {10.1016/j.biopsych.2014.12.019},
  pmid    = {25676491},
  url     = {https://doi.org/10.1016/j.biopsych.2014.12.019}
}

@article{pratt2015-6e8cc850,
  author  = {Pratt, William B. and Gestwicki, Jason E. and Osawa, Yoichi and Lieberman, Andrew P.},
  title   = {{Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases}},
  journal = {Annual Review of Pharmacology and Toxicology},
  year    = {2015},
  doi     = {10.1146/annurev-pharmtox-010814-124332},
  url     = {https://doi.org/10.1146/annurev-pharmtox-010814-124332}
}

@article{xia2015-25558816,
  author  = {Xia, D. and Li, C. and Götz, J.},
  title   = {{Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines}},
  journal = {Biochimica et biophysica acta},
  year    = {2015},
  doi     = {10.1016/j.bbadis.2014.12.017},
  pmid    = {25558816},
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}

@article{friedland2015-25589730,
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  year    = {2015},
  doi     = {10.3233/jad-142841},
  pmid    = {25589730},
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}

@article{burte2015-25486875,
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  journal = {Nature reviews. Neurology},
  year    = {2015},
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}

@article{videnovic2014-25385339,
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  title   = {{'The clocks that time us'--circadian rhythms in neurodegenerative disorders}},
  journal = {Nature reviews. Neurology},
  year    = {2014},
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@article{fernandez2014-25239621,
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  title   = {{Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m114.581165},
  pmid    = {25239621},
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@article{herassandoval2014-25173700,
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  title   = {{The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration}},
  journal = {Cellular signalling},
  year    = {2014},
  doi     = {10.1016/j.cellsig.2014.08.019},
  pmid    = {25173700},
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@article{ittner2015-25041093,
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  title   = {{Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice}},
  journal = {Journal of neurochemistry},
  year    = {2015},
  doi     = {10.1111/jnc.12821},
  pmid    = {25041093},
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@article{xiao2014-25031402,
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  title   = {{Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2014},
  doi     = {10.1523/jneurosci.3788-13.2014},
  pmid    = {25031402},
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@article{knowles2014-24854788,
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  title   = {{The amyloid state and its association with protein misfolding diseases}},
  journal = {Nature reviews. Molecular cell biology},
  year    = {2014},
  doi     = {10.1038/nrm3810},
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}

@article{spiresjones2014-24853936,
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  title   = {{The intersection of amyloid beta and tau at synapses in Alzheimer's disease}},
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  year    = {2014},
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  pmid    = {24853936},
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@article{parsons2014-24742457,
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@article{hardy2014-24749173,
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  title   = {{Pathways to Alzheimer's disease}},
  journal = {Journal of internal medicine},
  year    = {2014},
  doi     = {10.1111/joim.12192},
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@article{dimeco2014-24629673,
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  title   = {{Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.02.011},
  pmid    = {24629673},
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@article{castillocarranza2014-24603946,
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  title   = {{Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-132477},
  pmid    = {24603946},
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@article{niewoehner2014-24411731,
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  title   = {{Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle}},
  journal = {Neuron},
  year    = {2014},
  doi     = {10.1016/j.neuron.2013.10.061},
  pmid    = {24411731},
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@article{ghavami2014-24211851,
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  title   = {{Autophagy and apoptosis dysfunction in neurodegenerative disorders}},
  journal = {Progress in neurobiology},
  year    = {2014},
  doi     = {10.1016/j.pneurobio.2013.10.004},
  pmid    = {24211851},
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@article{puzzo2014-24112792,
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  title   = {{Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.09.002},
  pmid    = {24112792},
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@article{murray2014-24103379,
  author  = {Murray, P. S. and Kumar, S. and Demichele-Sweet, M. A. and Sweet, R. A.},
  title   = {{Psychosis in Alzheimer's disease}},
  journal = {Biological psychiatry},
  year    = {2014},
  doi     = {10.1016/j.biopsych.2013.08.020},
  pmid    = {24103379},
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@article{yanamandra2013-24075978,
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  title   = {{Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo}},
  journal = {Neuron},
  year    = {2013},
  doi     = {10.1016/j.neuron.2013.07.046},
  pmid    = {24075978},
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@article{um2013-24012003,
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  title   = {{Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein}},
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  year    = {2013},
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  pmid    = {24012003},
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@article{okamura2013-23857514,
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  title   = {{Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2013},
  doi     = {10.2967/jnumed.112.117341},
  pmid    = {23857514},
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@article{devos2013-23904623,
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  title   = {{Antisense reduction of tau in adult mice protects against seizures}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2013},
  doi     = {10.1523/jneurosci.2107-13.2013},
  pmid    = {23904623},
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@article{guo2013-23827677,
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  title   = {{Distinct α-synuclein strains differentially promote tau inclusions in neurons}},
  journal = {Cell},
  year    = {2013},
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  pmid    = {23827677},
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@article{rosenman2013-23811057,
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  title   = {{Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach}},
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  year    = {2013},
  doi     = {10.1016/j.jmb.2013.06.021},
  pmid    = {23811057},
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@article{talantova2013-23776240,
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  title   = {{Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss}},
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  year    = {2013},
  doi     = {10.1073/pnas.1306832110},
  pmid    = {23776240},
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@article{shaw2013-23697802,
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  title   = {{Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation}},
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  year    = {2013},
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  pmid    = {23697802},
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@article{trillo2013-23707776,
  author  = {Trillo, L. and Das, D. and Hsieh, W. and Medina, B. and Moghadam, S. and Lin, B. and Dang, V. and Sanchez, M. M. and others},
  title   = {{Ascending monoaminergic systems alterations in Alzheimer's disease. translating basic science into clinical care}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2013},
  doi     = {10.1016/j.neubiorev.2013.05.008},
  pmid    = {23707776},
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@article{velazquez2013-23643842,
  author  = {Velazquez, R. and Ash, J. A. and Powers, B. E. and Kelley, C. M. and Strawderman, M. and Luscher, Z. I. and Ginsberg, S. D. and Mufson, E. J. and others},
  title   = {{Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome}},
  journal = {Neurobiology of disease},
  year    = {2013},
  doi     = {10.1016/j.nbd.2013.04.016},
  pmid    = {23643842},
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@article{djogo2013-23639788,
  author  = {Djogo, N. and Jakovcevski, I. and Müller, C. and Lee, H. J. and Xu, J. C. and Jakovcevski, M. and Kügler, S. and Loers, G. and others},
  title   = {{Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice}},
  journal = {Neurobiology of disease},
  year    = {2013},
  doi     = {10.1016/j.nbd.2013.04.014},
  pmid    = {23639788},
  url     = {https://doi.org/10.1016/j.nbd.2013.04.014}
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@article{armato2013-23628734,
  author  = {Armato, U. and Chiarini, A. and Chakravarthy, B. and Chioffi, F. and Pacchiana, R. and Colarusso, E. and Whitfield, J. F. and Dal Prà, I.},
  title   = {{Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease}},
  journal = {Biochimica et biophysica acta},
  year    = {2013},
  doi     = {10.1016/j.bbadis.2013.04.020},
  pmid    = {23628734},
  url     = {https://doi.org/10.1016/j.bbadis.2013.04.020}
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@article{didomenico2013-23603808,
  author  = {Di Domenico, F. and Coccia, R. and Cocciolo, A. and Murphy, M. P. and Cenini, G. and Head, E. and Butterfield, D. A. and Giorgi, A. and others},
  title   = {{Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain}},
  journal = {Biochimica et biophysica acta},
  year    = {2013},
  doi     = {10.1016/j.bbadis.2013.04.013},
  pmid    = {23603808},
  url     = {https://doi.org/10.1016/j.bbadis.2013.04.013}
}

@article{hefti2013-23582316,
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  title   = {{The case for soluble Aβ oligomers as a drug target in Alzheimer's disease}},
  journal = {Trends in pharmacological sciences},
  year    = {2013},
  doi     = {10.1016/j.tips.2013.03.002},
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  url     = {https://doi.org/10.1016/j.tips.2013.03.002}
}

@article{appelcresswell2013-23457019,
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  title   = {{Alpha‐synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease}},
  journal = {Movement Disorders},
  year    = {2013},
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  pmid    = {23457019},
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@article{kondo2013-23434393,
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  title   = {{Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness}},
  journal = {Cell stem cell},
  year    = {2013},
  doi     = {10.1016/j.stem.2013.01.009},
  pmid    = {23434393},
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@article{kim2013-23343194,
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  title   = {{Wnt/β-catenin signalling: from plasma membrane to nucleus}},
  journal = {The Biochemical journal},
  year    = {2013},
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  pmid    = {23343194},
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}

@article{allen2013-23348013,
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  title   = {{GDNF, NGF and BDNF as therapeutic options for neurodegeneration}},
  journal = {Pharmacology \& therapeutics},
  year    = {2013},
  doi     = {10.1016/j.pharmthera.2013.01.004},
  pmid    = {23348013},
  url     = {https://doi.org/10.1016/j.pharmthera.2013.01.004}
}

@article{xiong2013-24008687,
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  title   = {{The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-130584},
  pmid    = {24008687},
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}

@article{revett2013-22894822,
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  title   = {{Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology}},
  journal = {Journal of psychiatry \& neuroscience : JPN},
  year    = {2013},
  doi     = {10.1503/jpn.110190},
  pmid    = {22894822},
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}

@article{hernandez2013-22710914,
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  title   = {{GSK3 and tau: two convergence points in Alzheimer's disease}},
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  year    = {2013},
  doi     = {10.3233/jad-2012-129025},
  pmid    = {22710914},
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}

@article{hyttinen2013-23220125,
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  title   = {{Maturation of autophagosomes and endosomes: a key role for Rab7}},
  journal = {Biochimica et biophysica acta},
  year    = {2013},
  doi     = {10.1016/j.bbamcr.2012.11.018},
  pmid    = {23220125},
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}

@article{goedert2013-23183883,
  author  = {Goedert, M. and Spillantini, M. G. and Del Tredici, K. and Braak, H.},
  title   = {{100 years of Lewy pathology}},
  journal = {Nature reviews. Neurology},
  year    = {2013},
  doi     = {10.1038/nrneurol.2012.242},
  pmid    = {23183883},
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@article{cheung2012-23035744,
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  title   = {{Structures of human acetylcholinesterase in complex with pharmacologically important ligands}},
  journal = {Journal of medicinal chemistry},
  year    = {2012},
  doi     = {10.1021/jm300871x},
  pmid    = {23035744},
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@article{tahtouh2012-22998443,
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  title   = {{Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B}},
  journal = {Journal of medicinal chemistry},
  year    = {2012},
  doi     = {10.1021/jm301034u},
  pmid    = {22998443},
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}

@article{kraft2013-23038755,
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  title   = {{Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2013},
  doi     = {10.1096/fj.12-208660},
  pmid    = {23038755},
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}

@article{bali2012-22949636,
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  title   = {{Role of genes linked to sporadic Alzheimer's disease risk in the production of β-amyloid peptides}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2012},
  doi     = {10.1073/pnas.1201632109},
  pmid    = {22949636},
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}

@article{roh2012-22956200,
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  title   = {{Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology}},
  journal = {Science translational medicine},
  year    = {2012},
  doi     = {10.1126/scitranslmed.3004291},
  pmid    = {22956200},
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}

@article{calcul2012-22924511,
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  title   = {{Natural products as a rich source of tau-targeting drugs for Alzheimer's disease}},
  journal = {Future medicinal chemistry},
  year    = {2012},
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  pmid    = {22924511},
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}

@article{danysz2012-22646481,
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  title   = {{Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections}},
  journal = {British journal of pharmacology},
  year    = {2012},
  doi     = {10.1111/j.1476-5381.2012.02057.x},
  pmid    = {22646481},
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}

@article{smith2012-23173067,
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  title   = {{Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?}},
  journal = {ACS chemical neuroscience},
  year    = {2012},
  doi     = {10.1021/cn300094k},
  pmid    = {23173067},
  url     = {https://doi.org/10.1021/cn300094k}
}

@article{sanchez2012-22869752,
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  title   = {{Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2012},
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  pmid    = {22869752},
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}

@article{mandelkow2012-22762014,
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  title   = {{Biochemistry and cell biology of tau protein in neurofibrillary degeneration}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
  doi     = {10.1101/cshperspect.a006247},
  pmid    = {22762014},
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}

@article{johri2012-22700435,
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  title   = {{Mitochondrial dysfunction in neurodegenerative diseases}},
  journal = {The Journal of pharmacology and experimental therapeutics},
  year    = {2012},
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}

@article{masters2012-22675658,
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  title   = {{Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
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  pmid    = {22675658},
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@article{troquier2012-22272619,
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  title   = {{Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach}},
  journal = {Current Alzheimer research},
  year    = {2012},
  doi     = {10.2174/156720512800492503},
  pmid    = {22272619},
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@article{koch2012-22510327,
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  title   = {{Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation}},
  journal = {The American journal of pathology},
  year    = {2012},
  doi     = {10.1016/j.ajpath.2012.02.012},
  pmid    = {22510327},
  url     = {https://doi.org/10.1016/j.ajpath.2012.02.012}
}

@article{shi2012-22344463,
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  title   = {{A human stem cell model of early Alzheimer's disease pathology in Down syndrome}},
  journal = {Science translational medicine},
  year    = {2012},
  doi     = {10.1126/scitranslmed.3003771},
  pmid    = {22344463},
  url     = {https://doi.org/10.1126/scitranslmed.3003771}
}

@article{bohrmann2012-21955818,
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  title   = {{Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2012},
  doi     = {10.3233/jad-2011-110977},
  pmid    = {21955818},
  url     = {https://doi.org/10.3233/jad-2011-110977}
}

@article{doggui2012-22426019,
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  title   = {{Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2012},
  doi     = {10.3233/jad-2012-112141},
  pmid    = {22426019},
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@article{lott2012-22541290,
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  title   = {{Neurological phenotypes for Down syndrome across the life span}},
  journal = {Progress in brain research},
  year    = {2012},
  doi     = {10.1016/b978-0-444-54299-1.00006-6},
  pmid    = {22541290},
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}

@article{narayan2011-22179788,
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  title   = {{The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide}},
  journal = {Nature structural \& molecular biology},
  year    = {2011},
  doi     = {10.1038/nsmb.2191},
  pmid    = {22179788},
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}

@article{pauwels2012-22157754,
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  title   = {{Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m111.264473},
  pmid    = {22157754},
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@article{quinteromonzon2011-21919498,
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  title   = {{Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations}},
  journal = {Biochemistry},
  year    = {2011},
  doi     = {10.1021/bi2007146},
  pmid    = {21919498},
  url     = {https://doi.org/10.1021/bi2007146}
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@article{yagi2011-21900357,
  author  = {Yagi, Takuya and Ito, Daisuke and Okada, Yohei and Akamatsu, Wado and Nihei, Yoshihiro and Yoshizaki, Takahito and Yamanaka, Shinya and Okano, Hideyuki and others},
  title   = {{Modeling familial Alzheimer's disease with induced pluripotent stem cells}},
  journal = {Human Molecular Genetics},
  year    = {2011},
  doi     = {10.1093/hmg/ddr394},
  pmid    = {21900357},
  url     = {https://doi.org/10.1093/hmg/ddr394}
}

@article{kummer2011-21903077,
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  title   = {{Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation}},
  journal = {Neuron},
  year    = {2011},
  doi     = {10.1016/j.neuron.2011.07.001},
  pmid    = {21903077},
  url     = {https://doi.org/10.1016/j.neuron.2011.07.001}
}

@article{calkins2011-21873260,
  author  = {Calkins, M. J. and Manczak, M. and Mao, P. and Shirendeb, U. and Reddy, P. H.},
  title   = {{Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease}},
  journal = {Human molecular genetics},
  year    = {2011},
  doi     = {10.1093/hmg/ddr381},
  pmid    = {21873260},
  url     = {https://doi.org/10.1093/hmg/ddr381}
}

@article{karran2011-21852788,
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  title   = {{The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics}},
  journal = {Nature reviews. Drug discovery},
  year    = {2011},
  doi     = {10.1038/nrd3505},
  pmid    = {21852788},
  url     = {https://doi.org/10.1038/nrd3505}
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@article{ding2011-21690377,
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  title   = {{Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2011},
  doi     = {10.1073/pnas.1100901108},
  pmid    = {21690377},
  url     = {https://doi.org/10.1073/pnas.1100901108}
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@article{debdab2011-21615147,
  author  = {Debdab, M. and Carreaux, F. and Renault, S. and Soundararajan, M. and Fedorov, O. and Filippakopoulos, P. and Lozach, O. and Babault, L. and others},
  title   = {{Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing}},
  journal = {Journal of medicinal chemistry},
  year    = {2011},
  doi     = {10.1021/jm200274d},
  pmid    = {21615147},
  url     = {https://doi.org/10.1021/jm200274d}
}

@article{nakamura2011-21597461,
  author  = {Nakamura, T. and Lipton, S. A.},
  title   = {{Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases}},
  journal = {Cell death and differentiation},
  year    = {2011},
  doi     = {10.1038/cdd.2011.65},
  pmid    = {21597461},
  url     = {https://doi.org/10.1038/cdd.2011.65}
}

@article{yu2011-21613623,
  author  = {Yu, Y. J. and Zhang, Y. and Kenrick, M. and Hoyte, K. and Luk, W. and Lu, Y. and Atwal, J. and Elliott, J. M. and others},
  title   = {{Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target}},
  journal = {Science translational medicine},
  year    = {2011},
  doi     = {10.1126/scitranslmed.3002230},
  pmid    = {21613623},
  url     = {https://doi.org/10.1126/scitranslmed.3002230}
}

@article{li2011-21543591,
  author  = {Li, S. and Jin, M. and Koeglsperger, T. and Shepardson, N. E. and Shankar, G. M. and Selkoe, D. J.},
  title   = {{Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2011},
  doi     = {10.1523/jneurosci.0203-11.2011},
  pmid    = {21543591},
  url     = {https://doi.org/10.1523/jneurosci.0203-11.2011}
}

@article{reifert2011-21482827,
  author  = {Reifert, J. and Hartung-Cranston, D. and Feinstein, S. C.},
  title   = {{Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m111.234674},
  pmid    = {21482827},
  url     = {https://doi.org/10.1074/jbc.m111.234674}
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@article{manczak2011-21459773,
  author  = {Manczak, M. and Calkins, M. J. and Reddy, P. H.},
  title   = {{Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage}},
  journal = {Human molecular genetics},
  year    = {2011},
  doi     = {10.1093/hmg/ddr139},
  pmid    = {21459773},
  url     = {https://doi.org/10.1093/hmg/ddr139}
}

@article{ohnomatsui2011-21440663,
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  title   = {{Parallel findings in age-related macular degeneration and Alzheimer's disease}},
  journal = {Progress in retinal and eye research},
  year    = {2011},
  doi     = {10.1016/j.preteyeres.2011.02.004},
  pmid    = {21440663},
  url     = {https://doi.org/10.1016/j.preteyeres.2011.02.004}
}

@article{texido2011-21349580,
  author  = {Texidó, L. and Martín-Satué, M. and Alberdi, E. and Solsona, C. and Matute, C.},
  title   = {{Amyloid β peptide oligomers directly activate NMDA receptors}},
  journal = {Cell calcium},
  year    = {2011},
  doi     = {10.1016/j.ceca.2011.02.001},
  pmid    = {21349580},
  url     = {https://doi.org/10.1016/j.ceca.2011.02.001}
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@article{daccache2011-21333710,
  author  = {Daccache, A. and Lion, C. and Sibille, N. and Gerard, M. and Slomianny, C. and Lippens, G. and Cotelle, P.},
  title   = {{Oleuropein and derivatives from olives as Tau aggregation inhibitors}},
  journal = {Neurochemistry international},
  year    = {2011},
  doi     = {10.1016/j.neuint.2011.02.010},
  pmid    = {21333710},
  url     = {https://doi.org/10.1016/j.neuint.2011.02.010}
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@article{desplats2011-21296890,
  author  = {Desplats, P. and Spencer, B. and Coffee, E. and Patel, P. and Michael, S. and Patrick, C. and Adame, A. and Rockenstein, E. and others},
  title   = {{Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.c110.212589},
  pmid    = {21296890},
  url     = {https://doi.org/10.1074/jbc.c110.212589}
}

@article{mookherjee2011-21677376,
  author  = {Mookherjee, P. and Green, P. S. and Watson, G. S. and Marques, M. A. and Tanaka, K. and Meeker, K. D. and Meabon, J. S. and Li, N. and others},
  title   = {{GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2011},
  doi     = {10.3233/jad-2011-110503},
  pmid    = {21677376},
  url     = {https://doi.org/10.3233/jad-2011-110503}
}

@article{obrien2011-21456963,
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  title   = {{Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease}},
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  year    = {2011},
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@article{jan2011-21156804,
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  title   = {{Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species}},
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  year    = {2011},
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@article{hoover2010-21172610,
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  title   = {{Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration}},
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@article{herrup2010-21159946,
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  year    = {2010},
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@article{ahn2010-21115843,
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  title   = {{Activation and intrinsic gamma-secretase activity of presenilin 1}},
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  year    = {2010},
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@article{kickstein2010-21098287,
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  title   = {{Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling}},
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  year    = {2010},
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@article{camandola2011-20950656,
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  title   = {{Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease}},
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  year    = {2011},
  doi     = {10.1016/j.bbamcr.2010.10.005},
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@article{du2010-20937894,
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  title   = {{Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2010},
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@article{kuperstein2010-20818335,
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  title   = {{Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio}},
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@article{kounnas2010-20826309,
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  title   = {{Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease}},
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@article{zempel2010-20826658,
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  title   = {{Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2010},
  doi     = {10.1523/jneurosci.2357-10.2010},
  pmid    = {20826658},
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@article{jones2011-20676620,
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  title   = {{The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics}},
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  year    = {2011},
  doi     = {10.1007/s00216-010-3968-1},
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@article{lipinski2010-20660724,
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  title   = {{Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease}},
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  year    = {2010},
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@article{decker2010-20610750,
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  title   = {{Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2010},
  doi     = {10.1523/jneurosci.1074-10.2010},
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@article{koronyohamaoui2011-20550967,
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  title   = {{Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model}},
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  year    = {2011},
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@article{lee2010-20541250,
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  title   = {{Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations}},
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@article{sterniczuk2010-20471965,
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  title   = {{Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes}},
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@article{citron2010-20431570,
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@article{crews2010-20413653,
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  title   = {{Molecular mechanisms of neurodegeneration in Alzheimer's disease}},
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  year    = {2010},
  doi     = {10.1093/hmg/ddq160},
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@article{bieschke2010-20385841,
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  title   = {{EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity}},
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  year    = {2010},
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  pmid    = {20385841},
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@article{adamcik2010-20383125,
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  title   = {{Understanding amyloid aggregation by statistical analysis of atomic force microscopy images}},
  journal = {Nature nanotechnology},
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@article{jang2010-20308552,
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  title   = {{Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome}},
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  year    = {2010},
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@article{caccamo2010-20178983,
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  title   = {{Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
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  pmid    = {20178983},
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@article{sakono2010-20148964,
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  year    = {2010},
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@article{dvir2010-20138030,
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  title   = {{Acetylcholinesterase: from 3D structure to function}},
  journal = {Chemico-biological interactions},
  year    = {2010},
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@article{luscher2010-20188650,
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@article{lemkul2010-20055378,
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  title   = {{Assessing the Stability of Alzheimer’s Amyloid Protofibrils Using Molecular Dynamics}},
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  year    = {2010},
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@article{radak2010-20182027,
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  title   = {{Exercise plays a preventive role against Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2010},
  doi     = {10.3233/jad-2010-091531},
  pmid    = {20182027},
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@article{jiang2010-20080541,
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  title   = {{Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition}},
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  year    = {2010},
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@article{dickson2009-20082965,
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  title   = {{Neuropathology of non-motor features of Parkinson disease}},
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  year    = {2009},
  doi     = {10.1016/s1353-8020(09)70769-2},
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@article{rhein2009-19897719,
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  title   = {{Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice}},
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  year    = {2009},
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@article{palop2010-19838821,
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@article{ghosal2009-19837693,
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  year    = {2009},
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@article{brunden2009-19794442,
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  title   = {{Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies}},
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@article{taly2009-19721446,
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  title   = {{Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system}},
  journal = {Nature reviews. Drug discovery},
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@article{park2009-19685005,
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  title   = {{Function and regulation of Dyrk1A: towards understanding Down syndrome}},
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  year    = {2009},
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@article{maurice2009-19619582,
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  title   = {{The pharmacology of sigma-1 receptors}},
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  year    = {2009},
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@article{hudson2009-19616561,
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  title   = {{(-)-epigallocatechin-3-gallate (EGCG) maintains kappa-casein in its pre-fibrillar state without redirecting its aggregation pathway}},
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  year    = {2009},
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  pmid    = {19616561},
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@article{bernstein2009-20703363,
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  title   = {{Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease}},
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  year    = {2009},
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@article{wang2009-19605646,
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  title   = {{Impaired balance of mitochondrial fission and fusion in Alzheimer's disease}},
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  year    = {2009},
  doi     = {10.1523/jneurosci.1357-09.2009},
  pmid    = {19605646},
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@article{peng2009-19625522,
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  title   = {{Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease}},
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  year    = {2009},
  doi     = {10.1523/jneurosci.4736-08.2009},
  pmid    = {19625522},
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@article{li2009-19555648,
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  title   = {{Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake}},
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  year    = {2009},
  doi     = {10.1016/j.neuron.2009.05.012},
  pmid    = {19555648},
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@article{boisselier2009-19587967,
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  title   = {{Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity}},
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  year    = {2009},
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  pmid    = {19587967},
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@article{duka2009-19369384,
  author  = {Duka, T. and Duka, V. and Joyce, J. N. and Sidhu, A.},
  title   = {{Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2009},
  doi     = {10.1096/fj.08-120410},
  pmid    = {19369384},
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@article{hellstromlindahl2009-19524115,
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  title   = {{Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease}},
  journal = {Neurochemistry international},
  year    = {2009},
  doi     = {10.1016/j.neuint.2009.03.007},
  pmid    = {19524115},
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@article{koffie2009-19228947,
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  title   = {{Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques}},
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  year    = {2009},
  doi     = {10.1073/pnas.0811698106},
  pmid    = {19228947},
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}

@article{defelice2009-19188609,
  author  = {De Felice, F. G. and Vieira, M. N. and Bomfim, T. R. and Decker, H. and Velasco, P. T. and Lambert, M. P. and Viola, K. L. and Zhao, W. Q. and others},
  title   = {{Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0809158106},
  pmid    = {19188609},
  url     = {https://doi.org/10.1073/pnas.0809158106}
}

@article{kong2009-19225343,
  author  = {Kong, G. Y. and Van Bergen, N. J. and Trounce, I. A. and Crowston, J. G.},
  title   = {{Mitochondrial dysfunction and glaucoma}},
  journal = {Journal of glaucoma},
  year    = {2009},
  doi     = {10.1097/ijg.0b013e318181284f},
  pmid    = {19225343},
  url     = {https://doi.org/10.1097/ijg.0b013e318181284f}
}

@article{bulic2009-19189357,
  author  = {Bulic, B. and Pickhardt, M. and Schmidt, B. and Mandelkow, E. M. and Waldmann, H. and Mandelkow, E.},
  title   = {{Development of tau aggregation inhibitors for Alzheimer's disease}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2009},
  doi     = {10.1002/anie.200802621},
  pmid    = {19189357},
  url     = {https://doi.org/10.1002/anie.200802621}
}

@article{powers2009-19298183,
  author  = {Powers, E. T. and Morimoto, R. I. and Dillin, A. and Kelly, J. W. and Balch, W. E.},
  title   = {{Biological and chemical approaches to diseases of proteostasis deficiency}},
  journal = {Annual review of biochemistry},
  year    = {2009},
  doi     = {10.1146/annurev.biochem.052308.114844},
  pmid    = {19298183},
  url     = {https://doi.org/10.1146/annurev.biochem.052308.114844}
}

@article{knott2008-19076450,
  author  = {Knott, A. B. and Bossy-Wetzel, E.},
  title   = {{Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2008},
  doi     = {10.1196/annals.1427.030},
  pmid    = {19076450},
  url     = {https://doi.org/10.1196/annals.1427.030}
}

@article{mattson2008-19081372,
  author  = {Mattson, M. P. and Gleichmann, M. and Cheng, A.},
  title   = {{Mitochondria in neuroplasticity and neurological disorders}},
  journal = {Neuron},
  year    = {2008},
  doi     = {10.1016/j.neuron.2008.10.010},
  pmid    = {19081372},
  url     = {https://doi.org/10.1016/j.neuron.2008.10.010}
}

@article{puzzo2008-19118188,
  author  = {Puzzo, D. and Privitera, L. and Leznik, E. and Fà, M. and Staniszewski, A. and Palmeri, A. and Arancio, O.},
  title   = {{Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2008},
  doi     = {10.1523/jneurosci.2692-08.2008},
  pmid    = {19118188},
  url     = {https://doi.org/10.1523/jneurosci.2692-08.2008}
}

@article{paravastu2008-19015532,
  author  = {Paravastu, A. K. and Leapman, R. D. and Yau, W. M. and Tycko, R.},
  title   = {{Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2008},
  doi     = {10.1073/pnas.0806270105},
  pmid    = {19015532},
  url     = {https://doi.org/10.1073/pnas.0806270105}
}

@article{lubke2009-18977398,
  author  = {Lübke, T. and Lobel, P. and Sleat, D. E.},
  title   = {{Proteomics of the lysosome}},
  journal = {Biochimica et biophysica acta},
  year    = {2009},
  doi     = {10.1016/j.bbamcr.2008.09.018},
  pmid    = {18977398},
  url     = {https://doi.org/10.1016/j.bbamcr.2008.09.018}
}

@article{ittner2008-18832465,
  author  = {Ittner, L. M. and Fath, T. and Ke, Y. D. and Bi, M. and van Eersel, J. and Li, K. M. and Gunning, P. and Götz, J.},
  title   = {{Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2008},
  doi     = {10.1073/pnas.0808084105},
  pmid    = {18832465},
  url     = {https://doi.org/10.1073/pnas.0808084105}
}

@article{perez2009-18791173,
  author  = {Perez, S. E. and Lumayag, S. and Kovacs, B. and Mufson, E. J. and Xu, S.},
  title   = {{Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease}},
  journal = {Investigative ophthalmology \& visual science},
  year    = {2009},
  doi     = {10.1167/iovs.08-2384},
  pmid    = {18791173},
  url     = {https://doi.org/10.1167/iovs.08-2384}
}

@article{hanssonpetersen2008-18757748,
  author  = {Hansson Petersen, C. A. and Alikhani, N. and Behbahani, H. and Wiehager, B. and Pavlov, P. F. and Alafuzoff, I. and Leinonen, V. and Ito, A. and others},
  title   = {{The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2008},
  doi     = {10.1073/pnas.0806192105},
  pmid    = {18757748},
  url     = {https://doi.org/10.1073/pnas.0806192105}
}

@article{toledo2008-18786602,
  author  = {Toledo, E. M. and Colombres, M. and Inestrosa, N. C.},
  title   = {{Wnt signaling in neuroprotection and stem cell differentiation}},
  journal = {Progress in neurobiology},
  year    = {2008},
  doi     = {10.1016/j.pneurobio.2008.08.001},
  pmid    = {18786602},
  url     = {https://doi.org/10.1016/j.pneurobio.2008.08.001}
}

@article{tapiaarancibia2008-18708092,
  author  = {Tapia-Arancibia, L. and Aliaga, E. and Silhol, M. and Arancibia, S.},
  title   = {{New insights into brain BDNF function in normal aging and Alzheimer disease}},
  journal = {Brain research reviews},
  year    = {2008},
  doi     = {10.1016/j.brainresrev.2008.07.007},
  pmid    = {18708092},
  url     = {https://doi.org/10.1016/j.brainresrev.2008.07.007}
}

@article{bezprozvanny2008-18675468,
  author  = {Bezprozvanny, I. and Mattson, M. P.},
  title   = {{Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease}},
  journal = {Trends in neurosciences},
  year    = {2008},
  doi     = {10.1016/j.tins.2008.06.005},
  pmid    = {18675468},
  url     = {https://doi.org/10.1016/j.tins.2008.06.005}
}

@article{schneider2008-18625456,
  author  = {Schneider, A. and Mandelkow, E.},
  title   = {{Tau-based treatment strategies in neurodegenerative diseases}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2008},
  doi     = {10.1016/j.nurt.2008.05.006},
  pmid    = {18625456},
  url     = {https://doi.org/10.1016/j.nurt.2008.05.006}
}

@article{shelat2008-18346200,
  author  = {Shelat, P. B. and Chalimoniuk, M. and Wang, J. H. and Strosznajder, J. B. and Lee, J. C. and Sun, A. Y. and Simonyi, A. and Sun, G. Y.},
  title   = {{Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2008.05347.x},
  pmid    = {18346200},
  url     = {https://doi.org/10.1111/j.1471-4159.2008.05347.x}
}

@article{adlard2008-18614028,
  author  = {Adlard, P. A. and Cherny, R. A. and Finkelstein, D. I. and Gautier, E. and Robb, E. and Cortes, M. and Volitakis, I. and Liu, X. and others},
  title   = {{Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta}},
  journal = {Neuron},
  year    = {2008},
  doi     = {10.1016/j.neuron.2008.06.018},
  pmid    = {18614028},
  url     = {https://doi.org/10.1016/j.neuron.2008.06.018}
}

@article{boland2008-18596167,
  author  = {Boland, B. and Kumar, A. and Lee, S. and Platt, F. M. and Wegiel, J. and Yu, W. H. and Nixon, R. A.},
  title   = {{Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2008},
  doi     = {10.1523/jneurosci.0800-08.2008},
  pmid    = {18596167},
  url     = {https://doi.org/10.1523/jneurosci.0800-08.2008}
}

@article{ehrnhoefer2008-18511942,
  author  = {Ehrnhoefer, D. E. and Bieschke, J. and Boeddrich, A. and Herbst, M. and Masino, L. and Lurz, R. and Engemann, S. and Pastore, A. and others},
  title   = {{EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers}},
  journal = {Nature structural \& molecular biology},
  year    = {2008},
  doi     = {10.1038/nsmb.1437},
  pmid    = {18511942},
  url     = {https://doi.org/10.1038/nsmb.1437}
}

@article{sergeant2008-18466052,
  author  = {Sergeant, N. and Bretteville, A. and Hamdane, M. and Caillet-Boudin, M. L. and Grognet, P. and Bombois, S. and Blum, D. and Delacourte, A. and others},
  title   = {{Biochemistry of Tau in Alzheimer's disease and related neurological disorders}},
  journal = {Expert review of proteomics},
  year    = {2008},
  doi     = {10.1586/14789450.5.2.207},
  pmid    = {18466052},
  url     = {https://doi.org/10.1586/14789450.5.2.207}
}

@article{barnham2008-18342639,
  author  = {Barnham, K. J. and Bush, A. I.},
  title   = {{Metals in Alzheimer's and Parkinson's diseases}},
  journal = {Current opinion in chemical biology},
  year    = {2008},
  doi     = {10.1016/j.cbpa.2008.02.019},
  pmid    = {18342639},
  url     = {https://doi.org/10.1016/j.cbpa.2008.02.019}
}

@article{selkoe2008-18359102,
  author  = {Selkoe, D. J.},
  title   = {{Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior}},
  journal = {Behavioural brain research},
  year    = {2008},
  doi     = {10.1016/j.bbr.2008.02.016},
  pmid    = {18359102},
  url     = {https://doi.org/10.1016/j.bbr.2008.02.016}
}

@article{zhao2008-18295581,
  author  = {Zhao, C. and Deng, W. and Gage, F. H.},
  title   = {{Mechanisms and functional implications of adult neurogenesis}},
  journal = {Cell},
  year    = {2008},
  doi     = {10.1016/j.cell.2008.01.033},
  pmid    = {18295581},
  url     = {https://doi.org/10.1016/j.cell.2008.01.033}
}

@article{baron2008-18248604,
  author  = {Bar-On, P. and Crews, L. and Koob, A. O. and Mizuno, H. and Adame, A. and Spencer, B. and Masliah, E.},
  title   = {{Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2008.05254.x},
  pmid    = {18248604},
  url     = {https://doi.org/10.1111/j.1471-4159.2008.05254.x}
}

@article{reddy2008-18218341,
  author  = {Reddy, P. H. and Beal, M. F.},
  title   = {{Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease}},
  journal = {Trends in molecular medicine},
  year    = {2008},
  doi     = {10.1016/j.molmed.2007.12.002},
  pmid    = {18218341},
  url     = {https://doi.org/10.1016/j.molmed.2007.12.002}
}

@article{hoye2008-18193822,
  author  = {Hoye, A. T. and Davoren, J. E. and Wipf, P. and Fink, M. P. and Kagan, V. E.},
  title   = {{Targeting mitochondria}},
  journal = {Accounts of chemical research},
  year    = {2008},
  doi     = {10.1021/ar700135m},
  pmid    = {18193822},
  url     = {https://doi.org/10.1021/ar700135m}
}

@article{nunomura2007-18220780,
  author  = {Nunomura, A. and Moreira, P. I. and Lee, H. G. and Zhu, X. and Castellani, R. J. and Smith, M. A. and Perry, G.},
  title   = {{Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2007},
  doi     = {10.2174/187152707783399201},
  pmid    = {18220780},
  url     = {https://doi.org/10.2174/187152707783399201}
}

@article{nixon2007-18032783,
  author  = {Nixon, R. A.},
  title   = {{Autophagy, amyloidogenesis and Alzheimer disease}},
  journal = {Journal of cell science},
  year    = {2007},
  doi     = {10.1242/jcs.019265},
  pmid    = {18032783},
  url     = {https://doi.org/10.1242/jcs.019265}
}

@article{ryoo2008-18005339,
  author  = {Ryoo, SR. and Cho, H. J. and Lee, H. W. and Jeong, H. K. and Radnaabazar, C. and Kim, Y. S. and Kim, M. J. and Son, M. Y. and others},
  title   = {{Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2007.05075.x},
  pmid    = {18005339},
  url     = {https://doi.org/10.1111/j.1471-4159.2007.05075.x}
}

@article{bartolini2007-17939148,
  author  = {Bartolini, M. and Bertucci, C. and Bolognesi, M. L. and Cavalli, A. and Melchiorre, C. and Andrisano, V.},
  title   = {{Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action}},
  journal = {Chembiochem : a European journal of chemical biology},
  year    = {2007},
  doi     = {10.1002/cbic.200700427},
  pmid    = {17939148},
  url     = {https://doi.org/10.1002/cbic.200700427}
}

@article{zhu2007-17989287,
  author  = {Zhu, L. Q. and Wang, S. H. and Liu, D. and Yin, Y. Y. and Tian, Q. and Wang, X. C. and Wang, Q. and Chen, J. G. and others},
  title   = {{Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.3321-07.2007},
  pmid    = {17989287},
  url     = {https://doi.org/10.1523/jneurosci.3321-07.2007}
}

@article{berrykravis2007-17618523,
  author  = {Berry-Kravis, E. and Abrams, L. and Coffey, S. M. and Hall, D. A. and Greco, C. and Gane, L. W. and Grigsby, J. and Bourgeois, J. A. and others},
  title   = {{Fragile X-associated tremor/ataxia syndrome: clinical features, genetics, and testing guidelines}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2007},
  doi     = {10.1002/mds.21493},
  pmid    = {17618523},
  url     = {https://doi.org/10.1002/mds.21493}
}

@article{palop2007-17785178,
  author  = {Palop, J. J. and Chin, J. and Roberson, E. D. and Wang, J. and Thwin, M. T. and Bien-Ly, N. and Yoo, J. and Ho, K. O. and others},
  title   = {{Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease}},
  journal = {Neuron},
  year    = {2007},
  doi     = {10.1016/j.neuron.2007.07.025},
  pmid    = {17785178},
  url     = {https://doi.org/10.1016/j.neuron.2007.07.025}
}

@article{levy2007-17846263,
  author  = {Levy, G.},
  title   = {{The relationship of Parkinson disease with aging}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.9.1242},
  pmid    = {17846263},
  url     = {https://doi.org/10.1001/archneur.64.9.1242}
}

@article{jiang2007-17920001,
  author  = {Jiang, L. F. and Yao, T. M. and Zhu, Z. L. and Wang, C. and Ji, L. N.},
  title   = {{Impacts of Cd(II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain}},
  journal = {Biochimica et biophysica acta},
  year    = {2007},
  doi     = {10.1016/j.bbapap.2007.08.014},
  pmid    = {17920001},
  url     = {https://doi.org/10.1016/j.bbapap.2007.08.014}
}

@article{guo2007-17684098,
  author  = {Guo, L. and Salt, T. E. and Luong, V. and Wood, N. and Cheung, W. and Maass, A. and Ferrari, G. and others},
  title   = {{Targeting amyloid-beta in glaucoma treatment}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2007},
  doi     = {10.1073/pnas.0703707104},
  pmid    = {17684098},
  url     = {https://doi.org/10.1073/pnas.0703707104}
}

@article{uversky2007-17623039,
  author  = {Uversky, V. N.},
  title   = {{Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation}},
  journal = {Journal of neurochemistry},
  year    = {2007},
  doi     = {10.1111/j.1471-4159.2007.04764.x},
  pmid    = {17623039},
  url     = {https://doi.org/10.1111/j.1471-4159.2007.04764.x}
}

@article{ring2007-17634375,
  author  = {Ring, S. and Weyer, S. W. and Kilian, S. B. and Waldron, E. and Pietrzik, C. U. and Filippov, M. A. and Herms, J. and Buchholz, C. and others},
  title   = {{The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.1026-07.2007},
  pmid    = {17634375},
  url     = {https://doi.org/10.1523/jneurosci.1026-07.2007}
}

@article{butterfield2007-17664130,
  author  = {Butterfield, D. A. and Reed, T. and Newman, S. F. and Sultana, R.},
  title   = {{Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment}},
  journal = {Free radical biology \& medicine},
  year    = {2007},
  doi     = {10.1016/j.freeradbiomed.2007.05.037},
  pmid    = {17664130},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2007.05.037}
}

@article{lau2007-17514195,
  author  = {Lau, C. G. and Zukin, R. S.},
  title   = {{NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders}},
  journal = {Nature reviews. Neuroscience},
  year    = {2007},
  doi     = {10.1038/nrn2153},
  pmid    = {17514195},
  url     = {https://doi.org/10.1038/nrn2153}
}

@article{rukhsanasultana2007-17522440,
  author  = {Rukhsana Sultana, A. and Debra Boyd-kimball, A. and Cai, Jain and Pierce, William M. Jr. and Klein, Jon B. and Merchant, Michael L. and Butterfield, David Allan},
  title   = {{Proteomics Analysis of the Alzheimer's Disease Hippocampal Proteome}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2007},
  doi     = {10.3233/jad-2007-11203},
  pmid    = {17522440},
  url     = {https://doi.org/10.3233/jad-2007-11203}
}

@article{porzig2007-17499212,
  author  = {Porzig, R. and Singer, D. and Hoffmann, R.},
  title   = {{Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein}},
  journal = {Biochemical and biophysical research communications},
  year    = {2007},
  doi     = {10.1016/j.bbrc.2007.04.187},
  pmid    = {17499212},
  url     = {https://doi.org/10.1016/j.bbrc.2007.04.187}
}

@article{caccamo2007-17456772,
  author  = {Caccamo, A. and Oddo, S. and Tran, L. X. and LaFerla, F. M.},
  title   = {{Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles}},
  journal = {The American journal of pathology},
  year    = {2007},
  doi     = {10.2353/ajpath.2007.061178},
  pmid    = {17456772},
  url     = {https://doi.org/10.2353/ajpath.2007.061178}
}

@article{gupta2007-17301611,
  author  = {Gupta, N. and Yücel, Y. H.},
  title   = {{Glaucoma as a neurodegenerative disease}},
  journal = {Current opinion in ophthalmology},
  year    = {2007},
  doi     = {10.1097/icu.0b013e3280895aea},
  pmid    = {17301611},
  url     = {https://doi.org/10.1097/icu.0b013e3280895aea}
}

@article{shankar2007-17360908,
  author  = {Shankar, G. M. and Bloodgood, B. L. and Townsend, M. and Walsh, D. M. and Selkoe, D. J. and Sabatini, B. L.},
  title   = {{Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.4970-06.2007},
  pmid    = {17360908},
  url     = {https://doi.org/10.1523/jneurosci.4970-06.2007}
}

@article{planel2007-17376970,
  author  = {Planel, E. and Richter, K. E. and Nolan, C. E. and Finley, J. E. and Liu, L. and Wen, Y. and Krishnamurthy, P. and Herman, M. and others},
  title   = {{Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.4854-06.2007},
  pmid    = {17376970},
  url     = {https://doi.org/10.1523/jneurosci.4854-06.2007}
}

@article{mattson2007-17328689,
  author  = {Mattson, M. P.},
  title   = {{Calcium and neurodegeneration}},
  journal = {Aging cell},
  year    = {2007},
  doi     = {10.1111/j.1474-9726.2007.00275.x},
  pmid    = {17328689},
  url     = {https://doi.org/10.1111/j.1474-9726.2007.00275.x}
}

@article{defelice2007-17308309,
  author  = {De Felice, F. G. and Velasco, P. T. and Lambert, M. P. and Viola, K. and Fernandez, S. J. and Ferreira, S. T. and Klein, W. L.},
  title   = {{Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m607483200},
  pmid    = {17308309},
  url     = {https://doi.org/10.1074/jbc.m607483200}
}

@article{zuccato2007-17379385,
  author  = {Zuccato, C. and Cattaneo, E.},
  title   = {{Role of brain-derived neurotrophic factor in Huntington's disease}},
  journal = {Progress in neurobiology},
  year    = {2007},
  doi     = {10.1016/j.pneurobio.2007.01.003},
  pmid    = {17379385},
  url     = {https://doi.org/10.1016/j.pneurobio.2007.01.003}
}

@article{walsh2007-17286590,
  author  = {Walsh, D. M. and Selkoe, D. J.},
  title   = {{A beta oligomers - a decade of discovery}},
  journal = {Journal of neurochemistry},
  year    = {2007},
  doi     = {10.1111/j.1471-4159.2006.04426.x},
  pmid    = {17286590},
  url     = {https://doi.org/10.1111/j.1471-4159.2006.04426.x}
}

@article{wolfe2007-17268504,
  author  = {Wolfe, M. S.},
  title   = {{When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease}},
  journal = {EMBO reports},
  year    = {2007},
  doi     = {10.1038/sj.embor.7400896},
  pmid    = {17268504},
  url     = {https://doi.org/10.1038/sj.embor.7400896}
}

@article{rockenstein2007-17314294,
  author  = {Rockenstein, E. and Torrance, M. and Adame, A. and Mante, M. and Bar-on, P. and Rose, J. B. and Crews, L. and Masliah, E.},
  title   = {{Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.4321-06.2007},
  pmid    = {17314294},
  url     = {https://doi.org/10.1523/jneurosci.4321-06.2007}
}

@article{yoshida2007-17288551,
  author  = {Yoshida, H.},
  title   = {{ER stress and diseases}},
  journal = {The FEBS journal},
  year    = {2007},
  doi     = {10.1111/j.1742-4658.2007.05639.x},
  pmid    = {17288551},
  url     = {https://doi.org/10.1111/j.1742-4658.2007.05639.x}
}

@article{shioi2007-17254019,
  author  = {Shioi, J. and Georgakopoulos, A. and Mehta, P. and Kouchi, Z. and Litterst, C. M. and Baki, L. and Robakis, N. K.},
  title   = {{FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta}},
  journal = {Journal of neurochemistry},
  year    = {2007},
  doi     = {10.1111/j.1471-4159.2006.04391.x},
  pmid    = {17254019},
  url     = {https://doi.org/10.1111/j.1471-4159.2006.04391.x}
}

@article{lacor2007-17251419,
  author  = {Lacor, P. N. and Buniel, M. C. and Furlow, P. W. and Clemente, A. S. and Velasco, P. T. and Wood, M. and Viola, K. L. and Klein, W. L.},
  title   = {{Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.3501-06.2007},
  pmid    = {17251419},
  url     = {https://doi.org/10.1523/jneurosci.3501-06.2007}
}

@article{hsieh2006-17145504,
  author  = {Hsieh, H. and Boehm, J. and Sato, C. and Iwatsubo, T. and Tomita, T. and Sisodia, S. and Malinow, R.},
  title   = {{AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss}},
  journal = {Neuron},
  year    = {2006},
  doi     = {10.1016/j.neuron.2006.10.035},
  pmid    = {17145504},
  url     = {https://doi.org/10.1016/j.neuron.2006.10.035}
}

@article{niehrs2006-17143291,
  author  = {Niehrs, C.},
  title   = {{Function and biological roles of the Dickkopf family of Wnt modulators}},
  journal = {Oncogene},
  year    = {2006},
  doi     = {10.1038/sj.onc.1210054},
  pmid    = {17143291},
  url     = {https://doi.org/10.1038/sj.onc.1210054}
}

@article{chen2006-18654167,
  author  = {Chen, J. and Patil, S. and Seal, S. and McGinnis, J. F.},
  title   = {{Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides}},
  journal = {Nature nanotechnology},
  year    = {2006},
  doi     = {10.1038/nnano.2006.91},
  pmid    = {18654167},
  url     = {https://doi.org/10.1038/nnano.2006.91}
}

@article{zhu2007-17142016,
  author  = {Zhu, X. and Lee, H. G. and Perry, G. and Smith, M. A.},
  title   = {{Alzheimer disease, the two-hit hypothesis: an update}},
  journal = {Biochimica et biophysica acta},
  year    = {2007},
  doi     = {10.1016/j.bbadis.2006.10.014},
  pmid    = {17142016},
  url     = {https://doi.org/10.1016/j.bbadis.2006.10.014}
}

@article{gimenezllort2007-17055579,
  author  = {Giménez-Llort, L. and Blázquez, G. and Cañete, T. and Johansson, B. and Oddo, S. and Tobeña, A. and LaFerla, F. M. and Fernández-Teruel, A.},
  title   = {{Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2007},
  doi     = {10.1016/j.neubiorev.2006.07.007},
  pmid    = {17055579},
  url     = {https://doi.org/10.1016/j.neubiorev.2006.07.007}
}

@article{schliebs2006-17039298,
  author  = {Schliebs, R. and Arendt, T.},
  title   = {{The significance of the cholinergic system in the brain during aging and in Alzheimer's disease}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2006},
  doi     = {10.1007/s00702-006-0579-2},
  pmid    = {17039298},
  url     = {https://doi.org/10.1007/s00702-006-0579-2}
}

@article{yoshida2006-16987243,
  author  = {Yoshida, H. and Goedert, M.},
  title   = {{Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope}},
  journal = {Journal of neurochemistry},
  year    = {2006},
  doi     = {10.1111/j.1471-4159.2006.04052.x},
  pmid    = {16987243},
  url     = {https://doi.org/10.1111/j.1471-4159.2006.04052.x}
}

@article{patton2006-16936277,
  author  = {Patton, R. L. and Kalback, W. M. and Esh, C. L. and Kokjohn, T. A. and Van Vickle, G. D. and Luehrs, D. C. and Kuo, Y. M. and Lopez, J. and others},
  title   = {{Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis}},
  journal = {The American journal of pathology},
  year    = {2006},
  doi     = {10.2353/ajpath.2006.060269},
  pmid    = {16936277},
  url     = {https://doi.org/10.2353/ajpath.2006.060269}
}

@article{devi2006-16943564,
  author  = {Devi, L. and Prabhu, B. M. and Galati, D. F. and Avadhani, N. G. and Anandatheerthavarada, H. K.},
  title   = {{Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.1469-06.2006},
  pmid    = {16943564},
  url     = {https://doi.org/10.1523/jneurosci.1469-06.2006}
}

@article{gotti2006-16876883,
  author  = {Gotti, C. and Zoli, M. and Clementi, F.},
  title   = {{Brain nicotinic acetylcholine receptors: native subtypes and their relevance}},
  journal = {Trends in pharmacological sciences},
  year    = {2006},
  doi     = {10.1016/j.tips.2006.07.004},
  pmid    = {16876883},
  url     = {https://doi.org/10.1016/j.tips.2006.07.004}
}

@article{rajendran2006-16837572,
  author  = {Rajendran, L. and Honsho, M. and Zahn, T. R. and Keller, P. and Geiger, K. D. and Verkade, P. and Simons, K.},
  title   = {{Alzheimer's disease beta-amyloid peptides are released in association with exosomes}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0603838103},
  pmid    = {16837572},
  url     = {https://doi.org/10.1073/pnas.0603838103}
}

@article{sun2006-16816112,
  author  = {Sun, X. and He, G. and Song, W.},
  title   = {{BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2006},
  doi     = {10.1096/fj.05-5632com},
  pmid    = {16816112},
  url     = {https://doi.org/10.1096/fj.05-5632com}
}

@article{plattner2006-16803897,
  author  = {Plattner, F. and Angelo, M. and Giese, K. P.},
  title   = {{The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m603469200},
  pmid    = {16803897},
  url     = {https://doi.org/10.1074/jbc.m603469200}
}

@article{wolf2006-16806094,
  author  = {Wolf, S. A. and Kronenberg, G. and Lehmann, K. and Blankenship, A. and Overall, R. and Staufenbiel, M. and Kempermann, G.},
  title   = {{Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease}},
  journal = {Biological psychiatry},
  year    = {2006},
  doi     = {10.1016/j.biopsych.2006.04.004},
  pmid    = {16806094},
  url     = {https://doi.org/10.1016/j.biopsych.2006.04.004}
}

@article{butterfield2006-16860790,
  author  = {Butterfield, D. A. and Perluigi, M. and Sultana, R.},
  title   = {{Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics}},
  journal = {European journal of pharmacology},
  year    = {2006},
  doi     = {10.1016/j.ejphar.2006.06.026},
  pmid    = {16860790},
  url     = {https://doi.org/10.1016/j.ejphar.2006.06.026}
}

@article{sjoberg2006-16638814,
  author  = {Sjöberg, M. K. and Shestakova, E. and Mansuroglu, Z. and Maccioni, R. B. and Bonnefoy, E.},
  title   = {{Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization}},
  journal = {Journal of cell science},
  year    = {2006},
  doi     = {10.1242/jcs.02907},
  pmid    = {16638814},
  url     = {https://doi.org/10.1242/jcs.02907}
}

@article{malaplatearmand2006-16626961,
  author  = {Malaplate-Armand, C. and Florent-Béchard, S. and Youssef, I. and Koziel, V. and Sponne, I. and Kriem, B. and Leininger-Muller, B. and Olivier, J. L. and others},
  title   = {{Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway}},
  journal = {Neurobiology of disease},
  year    = {2006},
  doi     = {10.1016/j.nbd.2006.02.010},
  pmid    = {16626961},
  url     = {https://doi.org/10.1016/j.nbd.2006.02.010}
}

@article{mahley2006-16567625,
  author  = {Mahley, R. W. and Weisgraber, K. H. and Huang, Y.},
  title   = {{Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0600549103},
  pmid    = {16567625},
  url     = {https://doi.org/10.1073/pnas.0600549103}
}

@article{manczak2006-16551656,
  author  = {Manczak, M. and Anekonda, T. S. and Henson, E. and Park, B. S. and Quinn, J. and Reddy, P. H.},
  title   = {{Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression}},
  journal = {Human molecular genetics},
  year    = {2006},
  doi     = {10.1093/hmg/ddl066},
  pmid    = {16551656},
  url     = {https://doi.org/10.1093/hmg/ddl066}
}

@article{jacobsen2006-16549764,
  author  = {Jacobsen, J. S. and Wu, C. C. and Redwine, J. M. and Comery, T. A. and Arias, R. and Bowlby, M. and Martone, R. and Morrison, J. H. and others},
  title   = {{Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0600948103},
  pmid    = {16549764},
  url     = {https://doi.org/10.1073/pnas.0600948103}
}

@article{townsend2006-16469784,
  author  = {Townsend, M. and Shankar, G. M. and Mehta, T. and Walsh, D. M. and Selkoe, D. J.},
  title   = {{Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers}},
  journal = {The Journal of physiology},
  year    = {2006},
  doi     = {10.1113/jphysiol.2005.103754},
  pmid    = {16469784},
  url     = {https://doi.org/10.1113/jphysiol.2005.103754}
}

@article{tycko2006-16772049,
  author  = {Tycko, Robert},
  title   = {{Molecular structure of amyloid fibrils: insights from solid-state NMR}},
  journal = {Quarterly Reviews of Biophysics},
  year    = {2006},
  doi     = {10.1017/s0033583506004173},
  pmid    = {16772049},
  url     = {https://doi.org/10.1017/s0033583506004173}
}

@article{wang2006-16364209,
  author  = {Wang, J. Z. and Wang, Z. F.},
  title   = {{Role of melatonin in Alzheimer-like neurodegeneration}},
  journal = {Acta pharmacologica Sinica},
  year    = {2006},
  doi     = {10.1111/j.1745-7254.2006.00260.x},
  pmid    = {16364209},
  url     = {https://doi.org/10.1111/j.1745-7254.2006.00260.x}
}

@article{porat2006-16492146,
  author  = {Porat, Y. and Abramowitz, A. and Gazit, E.},
  title   = {{Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism}},
  journal = {Chemical biology \& drug design},
  year    = {2006},
  doi     = {10.1111/j.1747-0285.2005.00318.x},
  pmid    = {16492146},
  url     = {https://doi.org/10.1111/j.1747-0285.2005.00318.x}
}

@article{petkova2006-16401079,
  author  = {Petkova, A. T. and Yau, W. M. and Tycko, R.},
  title   = {{Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils}},
  journal = {Biochemistry},
  year    = {2006},
  doi     = {10.1021/bi051952q},
  pmid    = {16401079},
  url     = {https://doi.org/10.1021/bi051952q}
}

@article{laird2005-16354928,
  author  = {Laird, F. M. and Cai, H. and Savonenko, A. V. and Farah, M. H. and He, K. and Melnikova, T. and Wen, H. and Chiang, H. C. and others},
  title   = {{BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2766-05.2005},
  pmid    = {16354928},
  url     = {https://doi.org/10.1523/jneurosci.2766-05.2005}
}

@article{sultana2006-16271804,
  author  = {Sultana, R. and Boyd-Kimball, D. and Poon, H. F. and Cai, J. and Pierce, W. M. and Klein, J. B. and Merchant, M. and Markesbery, W. R. and others},
  title   = {{Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD}},
  journal = {Neurobiology of aging},
  year    = {2006},
  doi     = {10.1016/j.neurobiolaging.2005.09.021},
  pmid    = {16271804},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2005.09.021}
}

@article{klunk2005-16291932,
  author  = {Klunk, W. E. and Lopresti, B. J. and Ikonomovic, M. D. and Lefterov, I. M. and Koldamova, R. P. and Abrahamson, E. E. and Debnath, M. L. and Holt, D. P. and others},
  title   = {{Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2990-05.2005},
  pmid    = {16291932},
  url     = {https://doi.org/10.1523/jneurosci.2990-05.2005}
}

@article{caspersen2005-16210396,
  author  = {Caspersen, C. and Wang, N. and Yao, J. and Sosunov, A. and Chen, X. and Lustbader, J. W. and Xu, H. W. and Stern, D. and others},
  title   = {{Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2005},
  doi     = {10.1096/fj.05-3735fje},
  pmid    = {16210396},
  url     = {https://doi.org/10.1096/fj.05-3735fje}
}

@article{ding2005-16207876,
  author  = {Ding, Q. and Markesbery, W. R. and Chen, Q. and Li, F. and Keller, J. N.},
  title   = {{Ribosome dysfunction is an early event in Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.3040-05.2005},
  pmid    = {16207876},
  url     = {https://doi.org/10.1523/jneurosci.3040-05.2005}
}

@article{andersen2005-16174740,
  author  = {Andersen, O. M. and Reiche, J. and Schmidt, V. and Gotthardt, M. and Spoelgen, R. and Behlke, J. and von Arnim, C. A. and Breiderhoff, T. and others},
  title   = {{Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0503689102},
  pmid    = {16174740},
  url     = {https://doi.org/10.1073/pnas.0503689102}
}

@article{barghorn2005-16135089,
  author  = {Barghorn, S. and Nimmrich, V. and Striebinger, A. and Krantz, C. and Keller, P. and Janson, B. and Bahr, M. and Schmidt, M. and others},
  title   = {{Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2005},
  doi     = {10.1111/j.1471-4159.2005.03407.x},
  pmid    = {16135089},
  url     = {https://doi.org/10.1111/j.1471-4159.2005.03407.x}
}

@article{spires2005-16079410,
  author  = {Spires, T. L. and Meyer-Luehmann, M. and Stern, E. A. and McLean, P. J. and Skoch, J. and Nguyen, P. T. and Bacskai, B. J. and Hyman, B. T.},
  title   = {{Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.1879-05.2005},
  pmid    = {16079410},
  url     = {https://doi.org/10.1523/jneurosci.1879-05.2005}
}

@article{butterfield2005-16026957,
  author  = {Butterfield, D. A. and Poon, H. F.},
  title   = {{The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease}},
  journal = {Experimental gerontology},
  year    = {2005},
  doi     = {10.1016/j.exger.2005.05.007},
  pmid    = {16026957},
  url     = {https://doi.org/10.1016/j.exger.2005.05.007}
}

@article{quist2005-16020533,
  author  = {Quist, A. and Doudevski, I. and Lin, H. and Azimova, R. and Ng, D. and Frangione, B. and Kagan, B. and Ghiso, J. and others},
  title   = {{Amyloid ion channels: a common structural link for protein-misfolding disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0502066102},
  pmid    = {16020533},
  url     = {https://doi.org/10.1073/pnas.0502066102}
}

@article{williams2005-15883377,
  author  = {Williams, A. D. and Sega, M. and Chen, M. and Kheterpal, I. and Geva, M. and Berthelier, V. and Kaleta, D. T. and Cook, K. D. and others},
  title   = {{Structural properties of Abeta protofibrils stabilized by a small molecule}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0408582102},
  pmid    = {15883377},
  url     = {https://doi.org/10.1073/pnas.0408582102}
}

@article{noble2005-15867159,
  author  = {Noble, W. and Planel, E. and Zehr, C. and Olm, V. and Meyerson, J. and Suleman, F. and Gaynor, K. and Wang, L. and others},
  title   = {{Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0500466102},
  pmid    = {15867159},
  url     = {https://doi.org/10.1073/pnas.0500466102}
}

@article{caccamo2005-15708439,
  author  = {Caccamo, A. and Oddo, S. and Sugarman, M. C. and Akbari, Y. and LaFerla, F. M.},
  title   = {{Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders}},
  journal = {Neurobiology of aging},
  year    = {2005},
  doi     = {10.1016/j.neurobiolaging.2004.06.013},
  pmid    = {15708439},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.06.013}
}

@article{ishigami2005-15704193,
  author  = {Ishigami, A. and Ohsawa, T. and Hiratsuka, M. and Taguchi, H. and Kobayashi, S. and Saito, Y. and Murayama, S. and Asaga, H. and others},
  title   = {{Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease}},
  journal = {Journal of neuroscience research},
  year    = {2005},
  doi     = {10.1002/jnr.20431},
  pmid    = {15704193},
  url     = {https://doi.org/10.1002/jnr.20431}
}

@article{adlard2005-15858047,
  author  = {Adlard, P. A. and Perreau, V. M. and Pop, V. and Cotman, C. W.},
  title   = {{Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.0496-05.2005},
  pmid    = {15858047},
  url     = {https://doi.org/10.1523/jneurosci.0496-05.2005}
}

@article{nystrom2005-15775985,
  author  = {Nyström, T.},
  title   = {{Role of oxidative carbonylation in protein quality control and senescence}},
  journal = {The EMBO journal},
  year    = {2005},
  doi     = {10.1038/sj.emboj.7600599},
  pmid    = {15775985},
  url     = {https://doi.org/10.1038/sj.emboj.7600599}
}

@article{nixon2005-15639316,
  author  = {Nixon, R. A.},
  title   = {{Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases}},
  journal = {Neurobiology of aging},
  year    = {2005},
  doi     = {10.1016/j.neurobiolaging.2004.09.018},
  pmid    = {15639316},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.09.018}
}

@article{nixon2005-15751225,
  author  = {Nixon, R. A. and Wegiel, J. and Kumar, A. and Yu, W. H. and Peterhoff, C. and Cataldo, A. and Cuervo, A. M.},
  title   = {{Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2005},
  doi     = {10.1093/jnen/64.2.113},
  pmid    = {15751225},
  url     = {https://doi.org/10.1093/jnen/64.2.113}
}

@article{walker2005-15663477,
  author  = {Walker, E. S. and Martinez, M. and Brunkan, A. L. and Goate, A.},
  title   = {{Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios}},
  journal = {Journal of neurochemistry},
  year    = {2005},
  doi     = {10.1111/j.1471-4159.2004.02858.x},
  pmid    = {15663477},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02858.x}
}

@article{schroder2005-15603751,
  author  = {Schröder, M. and Kaufman, R. J.},
  title   = {{ER stress and the unfolded protein response}},
  journal = {Mutation research},
  year    = {2005},
  doi     = {10.1016/j.mrfmmm.2004.06.056},
  pmid    = {15603751},
  url     = {https://doi.org/10.1016/j.mrfmmm.2004.06.056}
}

@article{krebs2005-15629655,
  author  = {Krebs, M. R. and Bromley, E. H. and Donald, A. M.},
  title   = {{The binding of thioflavin-T to amyloid fibrils: localisation and implications}},
  journal = {Journal of structural biology},
  year    = {2005},
  doi     = {10.1016/j.jsb.2004.08.002},
  pmid    = {15629655},
  url     = {https://doi.org/10.1016/j.jsb.2004.08.002}
}

@article{yang2005-15590663,
  author  = {Yang, F. and Lim, G. P. and Begum, A. N. and Ubeda, O. J. and Simmons, M. R. and Ambegaokar, S. S. and Chen, P. P. and Kayed, R. and others},
  title   = {{Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m404751200},
  pmid    = {15590663},
  url     = {https://doi.org/10.1074/jbc.m404751200}
}

@article{greig2004-15681814,
  author  = {Greig, N. H. and Mattson, M. P. and Perry, T. and Chan, S. L. and Giordano, T. and Sambamurti, K. and Rogers, J. T. and Ovadia, H. and others},
  title   = {{New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2004},
  doi     = {10.1196/annals.1332.018},
  pmid    = {15681814},
  url     = {https://doi.org/10.1196/annals.1332.018}
}

@article{lovell2004-15665406,
  author  = {Lovell, M. A. and Xiong, S. and Xie, C. and Davies, P. and Markesbery, W. R.},
  title   = {{Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2004},
  doi     = {10.3233/jad-2004-6610},
  pmid    = {15665406},
  url     = {https://doi.org/10.3233/jad-2004-6610}
}

@article{selkoe2004-15516999,
  author  = {Selkoe, D. J.},
  title   = {{Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases}},
  journal = {Nature cell biology},
  year    = {2004},
  doi     = {10.1038/ncb1104-1054},
  pmid    = {15516999},
  url     = {https://doi.org/10.1038/ncb1104-1054}
}

@article{lacor2004-15537891,
  author  = {Lacor, P. N. and Buniel, M. C. and Chang, L. and Fernandez, S. J. and Gong, Y. and Viola, K. L. and Lambert, M. P. and Velasco, P. T. and others},
  title   = {{Synaptic targeting by Alzheimer's-related amyloid beta oligomers}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2004},
  doi     = {10.1523/jneurosci.3432-04.2004},
  pmid    = {15537891},
  url     = {https://doi.org/10.1523/jneurosci.3432-04.2004}
}

@article{wirths2004-15485483,
  author  = {Wirths, O. and Multhaup, G. and Bayer, T. A.},
  title   = {{A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade}},
  journal = {Journal of neurochemistry},
  year    = {2004},
  doi     = {10.1111/j.1471-4159.2004.02737.x},
  pmid    = {15485483},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02737.x}
}

@article{petrovsky2004-15479434,
  author  = {Petrovsky, N. and Aguilar, J. C.},
  title   = {{Vaccine adjuvants: current state and future trends}},
  journal = {Immunology and cell biology},
  year    = {2004},
  doi     = {10.1111/j.0818-9641.2004.01272.x},
  pmid    = {15479434},
  url     = {https://doi.org/10.1111/j.0818-9641.2004.01272.x}
}

@article{hahn2004-15365174,
  author  = {Hahn, P. and Qian, Y. and Dentchev, T. and Chen, L. and Beard, J. and Harris, Z. L. and Dunaief, J. L.},
  title   = {{Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2004},
  doi     = {10.1073/pnas.0405146101},
  pmid    = {15365174},
  url     = {https://doi.org/10.1073/pnas.0405146101}
}

@article{citron2004-15322526,
  author  = {Citron, M.},
  title   = {{Strategies for disease modification in Alzheimer's disease}},
  journal = {Nature reviews. Neuroscience},
  year    = {2004},
  doi     = {10.1038/nrn1495},
  pmid    = {15322526},
  url     = {https://doi.org/10.1038/nrn1495}
}

@article{nilsson2004-15283924,
  author  = {Nilsson, M. R.},
  title   = {{Techniques to study amyloid fibril formation in vitro}},
  journal = {Methods (San Diego, Calif.)},
  year    = {2004},
  doi     = {10.1016/j.ymeth.2004.03.012},
  pmid    = {15283924},
  url     = {https://doi.org/10.1016/j.ymeth.2004.03.012}
}

@article{walsh2004-15450169,
  author  = {Walsh, D. M. and Selkoe, D. J.},
  title   = {{Deciphering the molecular basis of memory failure in Alzheimer's disease}},
  journal = {Neuron},
  year    = {2004},
  doi     = {10.1016/j.neuron.2004.09.010},
  pmid    = {15450169},
  url     = {https://doi.org/10.1016/j.neuron.2004.09.010}
}

@article{poon2004-15262209,
  author  = {Poon, H. F. and Joshi, G. and Sultana, R. and Farr, S. A. and Banks, W. A. and Morley, J. E. and Calabrese, V. and Butterfield, D. A.},
  title   = {{Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice}},
  journal = {Brain research},
  year    = {2004},
  doi     = {10.1016/j.brainres.2004.05.048},
  pmid    = {15262209},
  url     = {https://doi.org/10.1016/j.brainres.2004.05.048}
}

@article{deane2004-15294142,
  author  = {Deane, R. and Wu, Z. and Sagare, A. and Davis, J. and Du Yan, S. and Hamm, K. and Xu, F. and Parisi, M. and others},
  title   = {{LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms}},
  journal = {Neuron},
  year    = {2004},
  doi     = {10.1016/j.neuron.2004.07.017},
  pmid    = {15294142},
  url     = {https://doi.org/10.1016/j.neuron.2004.07.017}
}

@article{yoshida2004-15228592,
  author  = {Yoshida, H. and Hastie, C. J. and McLauchlan, H. and Cohen, P. and Goedert, M.},
  title   = {{Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK)}},
  journal = {Journal of neurochemistry},
  year    = {2004},
  doi     = {10.1111/j.1471-4159.2004.02479.x},
  pmid    = {15228592},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02479.x}
}

@article{su2004-15170327,
  author  = {Su, Y. and Ryder, J. and Li, B. and Wu, X. and Fox, N. and Solenberg, P. and Brune, K. and Paul, S. and others},
  title   = {{Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing}},
  journal = {Biochemistry},
  year    = {2004},
  doi     = {10.1021/bi035627j},
  pmid    = {15170327},
  url     = {https://doi.org/10.1021/bi035627j}
}

@article{allinson2004-15182369,
  author  = {Allinson, T. M. and Parkin, E. T. and Condon, T. P. and Schwager, S. L. and Sturrock, E. D. and Turner, A. J. and Hooper, N. M.},
  title   = {{The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein}},
  journal = {European journal of biochemistry},
  year    = {2004},
  doi     = {10.1111/j.1432-1033.2004.04184.x},
  pmid    = {15182369},
  url     = {https://doi.org/10.1111/j.1432-1033.2004.04184.x}
}

@article{bhat2004-15189333,
  author  = {Bhat, R. V. and Budd Haeberlein, S. L. and Avila, J.},
  title   = {{Glycogen synthase kinase 3: a drug target for CNS therapies}},
  journal = {Journal of neurochemistry},
  year    = {2004},
  doi     = {10.1111/j.1471-4159.2004.02422.x},
  pmid    = {15189333},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02422.x}
}

@article{swatton2004-15147305,
  author  = {Swatton, J. E. and Sellers, L. A. and Faull, R. L. and Holland, A. and Iritani, S. and Bahn, S.},
  title   = {{Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain}},
  journal = {The European journal of neuroscience},
  year    = {2004},
  doi     = {10.1111/j.0953-816x.2004.03365.x},
  pmid    = {15147305},
  url     = {https://doi.org/10.1111/j.0953-816x.2004.03365.x}
}

@article{saura2004-15066262,
  author  = {Saura, C. A. and Choi, S. Y. and Beglopoulos, V. and Malkani, S. and Zhang, D. and Shankaranarayana Rao, B. S. and Chattarji, S. and Kelleher, R. J. and others},
  title   = {{Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration}},
  journal = {Neuron},
  year    = {2004},
  doi     = {10.1016/s0896-6273(04)00182-5},
  pmid    = {15066262},
  url     = {https://doi.org/10.1016/s0896-6273(04)00182-5}
}

@article{brecht2004-15014128,
  author  = {Brecht, W. J. and Harris, F. M. and Chang, S. and Tesseur, I. and Yu, G. Q. and Xu, Q. and Dee Fish, J. and Wyss-Coray, T. and others},
  title   = {{Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2004},
  doi     = {10.1523/jneurosci.4315-03.2004},
  pmid    = {15014128},
  url     = {https://doi.org/10.1523/jneurosci.4315-03.2004}
}

@article{louzada2004-15003996,
  author  = {Louzada, P. R. and Paula Lima, A. C. and Mendonca-Silva, D. L. and Noël, F. and De Mello, F. G. and Ferreira, S. T.},
  title   = {{Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2004},
  doi     = {10.1096/fj.03-0739com},
  pmid    = {15003996},
  url     = {https://doi.org/10.1096/fj.03-0739com}
}

@article{maiti2004-14982446,
  author  = {Maiti, Nakul C. and Apetri, Mihaela M. and Zagorski, Michael G. and CAREY, PAUL R. and Anderson, Vernon E.},
  title   = {{Raman Spectroscopic Characterization of Secondary Structure in Natively Unfolded Proteins: α-Synuclein}},
  journal = {Journal of the American Chemical Society},
  year    = {2004},
  doi     = {10.1021/ja0356176},
  pmid    = {14982446},
  url     = {https://doi.org/10.1021/ja0356176}
}

@article{petrucelli2004-14962978,
  author  = {Petrucelli, Leonard},
  title   = {{CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation}},
  journal = {Human Molecular Genetics},
  year    = {2004},
  doi     = {10.1093/hmg/ddh083},
  pmid    = {14962978},
  url     = {https://doi.org/10.1093/hmg/ddh083}
}

@article{choi2004-14722078,
  author  = {Choi, J. and Levey, A. I. and Weintraub, S. T. and Rees, H. D. and Gearing, M. and Chin, L. S. and Li, L.},
  title   = {{Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases}},
  journal = {The Journal of biological chemistry},
  year    = {2004},
  doi     = {10.1074/jbc.m314124200},
  pmid    = {14722078},
  url     = {https://doi.org/10.1074/jbc.m314124200}
}

@article{mathis2004-15134570,
  author  = {Mathis, C. A. and Wang, Y. and Klunk, W. E.},
  title   = {{Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain}},
  journal = {Current pharmaceutical design},
  year    = {2004},
  doi     = {10.2174/1381612043384772},
  pmid    = {15134570},
  url     = {https://doi.org/10.2174/1381612043384772}
}

@article{duckert2004-14985543,
  author  = {Duckert, P. and Brunak, S. and Blom, N.},
  title   = {{Prediction of proprotein convertase cleavage sites}},
  journal = {Protein engineering, design \& selection : PEDS},
  year    = {2004},
  doi     = {10.1093/protein/gzh013},
  pmid    = {14985543},
  url     = {https://doi.org/10.1093/protein/gzh013}
}

@article{oddo2003-14643377,
  author  = {Oddo, S. and Caccamo, A. and Kitazawa, M. and Tseng, B. P. and LaFerla, F. M.},
  title   = {{Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2003},
  doi     = {10.1016/j.neurobiolaging.2003.08.012},
  pmid    = {14643377},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2003.08.012}
}

@article{jankowsky2004-14645205,
  author  = {Jankowsky, J. L. and Fadale, D. J. and Anderson, J. and Xu, G. M. and Gonzales, V. and Jenkins, N. A. and Copeland, N. G. and Lee, M. K. and others},
  title   = {{Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase}},
  journal = {Human molecular genetics},
  year    = {2004},
  doi     = {10.1093/hmg/ddh019},
  pmid    = {14645205},
  url     = {https://doi.org/10.1093/hmg/ddh019}
}

@article{ciechanover2003-14556719,
  author  = {Ciechanover, A. and Brundin, P.},
  title   = {{The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00606-8},
  pmid    = {14556719},
  url     = {https://doi.org/10.1016/s0896-6273(03)00606-8}
}

@article{atwood2003-14499458,
  author  = {Atwood, C. S. and Obrenovich, M. E. and Liu, T. and Chan, H. and Perry, G. and Smith, M. A. and Martins, R. N.},
  title   = {{Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta}},
  journal = {Brain research. Brain research reviews},
  year    = {2003},
  doi     = {10.1016/s0165-0173(03)00174-7},
  pmid    = {14499458},
  url     = {https://doi.org/10.1016/s0165-0173(03)00174-7}
}

@article{horiguchi2003-12937143,
  author  = {Horiguchi, T. and Uryu, K. and Giasson, B. I. and Ischiropoulos, H. and LightFoot, R. and Bellmann, C. and Richter-Landsberg, C. and Lee, V. M. and others},
  title   = {{Nitration of tau protein is linked to neurodegeneration in tauopathies}},
  journal = {The American journal of pathology},
  year    = {2003},
  doi     = {10.1016/s0002-9440(10)63462-1},
  pmid    = {12937143},
  url     = {https://doi.org/10.1016/s0002-9440(10)63462-1}
}

@article{stefani2003-12942175,
  author  = {Stefani, M. and Dobson, C. M.},
  title   = {{Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution}},
  journal = {Journal of molecular medicine (Berlin, Germany)},
  year    = {2003},
  doi     = {10.1007/s00109-003-0464-5},
  pmid    = {12942175},
  url     = {https://doi.org/10.1007/s00109-003-0464-5}
}

@article{gong2003-12925731,
  author  = {Gong, Y. and Chang, L. and Viola, K. L. and Lacor, P. N. and Lambert, M. P. and Finch, C. E. and Krafft, G. A. and Klein, W. L.},
  title   = {{Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2003},
  doi     = {10.1073/pnas.1834302100},
  pmid    = {12925731},
  url     = {https://doi.org/10.1073/pnas.1834302100}
}

@article{cataldo2003-12890772,
  author  = {Cataldo, A. M. and Petanceska, S. and Peterhoff, C. M. and Terio, N. B. and Epstein, C. J. and Villar, A. and Carlson, E. J. and Staufenbiel, M. and others},
  title   = {{App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2003},
  doi     = {10.1523/jneurosci.23-17-06788.2003},
  pmid    = {12890772},
  url     = {https://doi.org/10.1523/jneurosci.23-17-06788.2003}
}

@article{castegna2003-12787059,
  author  = {Castegna, A. and Thongboonkerd, V. and Klein, J. B. and Lynn, B. and Markesbery, W. R. and Butterfield, D. A.},
  title   = {{Proteomic identification of nitrated proteins in Alzheimer's disease brain}},
  journal = {Journal of neurochemistry},
  year    = {2003},
  doi     = {10.1046/j.1471-4159.2003.01786.x},
  pmid    = {12787059},
  url     = {https://doi.org/10.1046/j.1471-4159.2003.01786.x}
}

@article{fahn2003-12846969,
  author  = {Fahn, S.},
  title   = {{Description of Parkinson's disease as a clinical syndrome}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2003},
  doi     = {10.1111/j.1749-6632.2003.tb07458.x},
  pmid    = {12846969},
  url     = {https://doi.org/10.1111/j.1749-6632.2003.tb07458.x}
}

@article{hoshi2003-12750461,
  author  = {Hoshi, M. and Sato, M. and Matsumoto, S. and Noguchi, A. and Yasutake, K. and Yoshida, N. and Sato, K.},
  title   = {{Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2003},
  doi     = {10.1073/pnas.1237107100},
  pmid    = {12750461},
  url     = {https://doi.org/10.1073/pnas.1237107100}
}

@article{dentchev2003-12764254,
  author  = {Dentchev, T. and Milam, A. H. and Lee, V. M. and Trojanowski, J. Q. and Dunaief, J. L.},
  title   = {{Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas}},
  journal = {Molecular vision},
  year    = {2003},
  pmid    = {12764254}
}

@article{kimberly2003-12740439,
  author  = {Kimberly, W. T. and LaVoie, M. J. and Ostaszewski, B. L. and Ye, W. and Wolfe, M. S. and Selkoe, D. J.},
  title   = {{Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2003},
  doi     = {10.1073/pnas.1037392100},
  pmid    = {12740439},
  url     = {https://doi.org/10.1073/pnas.1037392100}
}

@article{edbauer2003-12679784,
  author  = {Edbauer, D. and Winkler, E. and Regula, J. T. and Pesold, B. and Steiner, H. and Haass, C.},
  title   = {{Reconstitution of gamma-secretase activity}},
  journal = {Nature cell biology},
  year    = {2003},
  doi     = {10.1038/ncb960},
  pmid    = {12679784},
  url     = {https://doi.org/10.1038/ncb960}
}

@article{turner2003-12927332,
  author  = {Turner, P. R. and O'Connor, K. and Tate, W. P. and Abraham, W. C.},
  title   = {{Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory}},
  journal = {Progress in neurobiology},
  year    = {2003},
  doi     = {10.1016/s0301-0082(03)00089-3},
  pmid    = {12927332},
  url     = {https://doi.org/10.1016/s0301-0082(03)00089-3}
}

@article{destrooper2003-12691659,
  author  = {De Strooper, B.},
  title   = {{Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00205-8},
  pmid    = {12691659},
  url     = {https://doi.org/10.1016/s0896-6273(03)00205-8}
}

@article{harper2003-12667097,
  author  = {Harper, S. J. and Wilkie, N.},
  title   = {{MAPKs: new targets for neurodegeneration}},
  journal = {Expert opinion on therapeutic targets},
  year    = {2003},
  doi     = {10.1517/14728222.7.2.187},
  pmid    = {12667097},
  url     = {https://doi.org/10.1517/14728222.7.2.187}
}

@article{bush2003-12689772,
  author  = {Bush, A. I.},
  title   = {{The metallobiology of Alzheimer's disease}},
  journal = {Trends in neurosciences},
  year    = {2003},
  doi     = {10.1016/s0166-2236(03)00067-5},
  pmid    = {12689772},
  url     = {https://doi.org/10.1016/s0166-2236(03)00067-5}
}

@article{kamenetz2003-12670422,
  author  = {Kamenetz, F. and Tomita, T. and Hsieh, H. and Seabrook, G. and Borchelt, D. and Iwatsubo, T. and Sisodia, S. and Malinow, R.},
  title   = {{APP processing and synaptic function}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00124-7},
  pmid    = {12670422},
  url     = {https://doi.org/10.1016/s0896-6273(03)00124-7}
}

@article{bartolini2003-12527333,
  author  = {Bartolini, M. and Bertucci, C. and Cavrini, V. and Andrisano, V.},
  title   = {{beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies}},
  journal = {Biochemical pharmacology},
  year    = {2003},
  doi     = {10.1016/s0006-2952(02)01514-9},
  pmid    = {12527333},
  url     = {https://doi.org/10.1016/s0006-2952(02)01514-9}
}

@article{bimontenelson2003-12642175,
  author  = {Bimonte-Nelson, H. A. and Hunter, C. L. and Nelson, M. E. and Granholm, A. C.},
  title   = {{Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome}},
  journal = {Behavioural brain research},
  year    = {2003},
  doi     = {10.1016/s0166-4328(02)00082-7},
  pmid    = {12642175},
  url     = {https://doi.org/10.1016/s0166-4328(02)00082-7}
}

@article{melo2003-12507730,
  author  = {Melo, J. B. and Agostinho, P. and Oliveira, C. R.},
  title   = {{Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide}},
  journal = {Neuroscience research},
  year    = {2003},
  doi     = {10.1016/s0168-0102(02)00201-8},
  pmid    = {12507730},
  url     = {https://doi.org/10.1016/s0168-0102(02)00201-8}
}

@article{banks2003-14522007,
  author  = {Banks, W. A. and Robinson, S. M. and Verma, S. and Morley, J. E.},
  title   = {{Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease}},
  journal = {Neuroscience},
  year    = {2003},
  doi     = {10.1016/s0306-4522(03)00474-3},
  pmid    = {14522007},
  url     = {https://doi.org/10.1016/s0306-4522(03)00474-3}
}

@article{fantini2002-14987385,
  author  = {Fantini, Jacques and Garmy, Nicolas and Mahfoud, Radhia and Yahi, Nouara},
  title   = {{Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases}},
  journal = {Expert Reviews in Molecular Medicine},
  year    = {2002},
  doi     = {10.1017/s1462399402005392},
  pmid    = {14987385},
  url     = {https://doi.org/10.1017/s1462399402005392}
}

@article{miguelhidalgo2002-12468047,
  author  = {Miguel-Hidalgo, J. J. and Alvarez, X. A. and Cacabelos, R. and Quack, G.},
  title   = {{Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40)}},
  journal = {Brain research},
  year    = {2002},
  doi     = {10.1016/s0006-8993(02)03731-9},
  pmid    = {12468047},
  url     = {https://doi.org/10.1016/s0006-8993(02)03731-9}
}

@article{butterfield2002-12607822,
  author  = {Butterfield, D. A.},
  title   = {{Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review}},
  journal = {Free radical research},
  year    = {2002},
  doi     = {10.1080/1071576021000049890},
  pmid    = {12607822},
  url     = {https://doi.org/10.1080/1071576021000049890}
}

@article{poduslo2002-12505424,
  author  = {Poduslo, J. F. and Wengenack, T. M. and Curran, G. L. and Wisniewski, T. and Sigurdsson, E. M. and Macura, S. I. and Borowski, B. J. and Jack, C. R.},
  title   = {{Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging}},
  journal = {Neurobiology of disease},
  year    = {2002},
  doi     = {10.1006/nbdi.2002.0550},
  pmid    = {12505424},
  url     = {https://doi.org/10.1006/nbdi.2002.0550}
}

@article{yin2002-12427831,
  author  = {Yin, K. J. and Lee, J. M. and Chen, S. D. and Xu, J. and Hsu, C. Y.},
  title   = {{Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2002},
  doi     = {10.1523/jneurosci.22-22-09764.2002},
  pmid    = {12427831},
  url     = {https://doi.org/10.1523/jneurosci.22-22-09764.2002}
}

@article{vitolo2002-12244210,
  author  = {Vitolo, O. V. and Sant'Angelo, A. and Costanzo, V. and Battaglia, F. and Arancio, O. and Shelanski, M.},
  title   = {{Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2002},
  doi     = {10.1073/pnas.172504199},
  pmid    = {12244210},
  url     = {https://doi.org/10.1073/pnas.172504199}
}

@article{butterfield2002-12392766,
  author  = {Butterfield, D. A. and Castegna, A. and Lauderback, C. M. and Drake, J.},
  title   = {{Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death}},
  journal = {Neurobiology of aging},
  year    = {2002},
  doi     = {10.1016/s0197-4580(01)00340-2},
  pmid    = {12392766},
  url     = {https://doi.org/10.1016/s0197-4580(01)00340-2}
}

@article{castegna2002-12354300,
  author  = {Castegna, A. and Aksenov, M. and Thongboonkerd, V. and Klein, J. B. and Pierce, W. M. and Booze, R. and Markesbery, W. R. and Butterfield, D. A.},
  title   = {{Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71}},
  journal = {Journal of neurochemistry},
  year    = {2002},
  doi     = {10.1046/j.1471-4159.2002.01103.x},
  pmid    = {12354300},
  url     = {https://doi.org/10.1046/j.1471-4159.2002.01103.x}
}

@article{johnson2002-12189211,
  author  = {Johnson, L. V. and Leitner, W. P. and Rivest, A. J. and Staples, M. K. and Radeke, M. J. and Anderson, D. H.},
  title   = {{The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2002},
  doi     = {10.1073/pnas.192203399},
  pmid    = {12189211},
  url     = {https://doi.org/10.1073/pnas.192203399}
}

@article{castegna2002-12160938,
  author  = {Castegna, A. and Aksenov, M. and Aksenova, M. and Thongboonkerd, V. and Klein, J. B. and Pierce, W. M. and Booze, R. and Markesbery, W. R. and others},
  title   = {{Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1}},
  journal = {Free radical biology \& medicine},
  year    = {2002},
  doi     = {10.1016/s0891-5849(02)00914-0},
  pmid    = {12160938},
  url     = {https://doi.org/10.1016/s0891-5849(02)00914-0}
}

@article{fiala2002-12086707,
  author  = {Fiala, J. C. and Spacek, J. and Harris, K. M.},
  title   = {{Dendritic spine pathology: cause or consequence of neurological disorders?}},
  journal = {Brain research. Brain research reviews},
  year    = {2002},
  doi     = {10.1016/s0165-0173(02)00158-3},
  pmid    = {12086707},
  url     = {https://doi.org/10.1016/s0165-0173(02)00158-3}
}

@article{mori2002-12440481,
  author  = {Mori, C. and Spooner, E. T. and Wisniewsk, K. E. and Wisniewski, T. M. and Yamaguch, H. and Saido, T. C. and Tolan, D. R. and Selkoe, D. J. and others},
  title   = {{Intraneuronal Abeta42 accumulation in Down syndrome brain}},
  journal = {Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis},
  year    = {2002},
  doi     = {10.3109/13506120208995241},
  pmid    = {12440481},
  url     = {https://doi.org/10.3109/13506120208995241}
}

@article{ravikumar2002-11978769,
  author  = {Ravikumar, B. and Duden, R. and Rubinsztein, D. C.},
  title   = {{Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy}},
  journal = {Human molecular genetics},
  year    = {2002},
  doi     = {10.1093/hmg/11.9.1107},
  pmid    = {11978769},
  url     = {https://doi.org/10.1093/hmg/11.9.1107}
}

@article{shim2002-12009525,
  author  = {Shim, K. S. and Lubec, G.},
  title   = {{Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome}},
  journal = {Neuroscience letters},
  year    = {2002},
  doi     = {10.1016/s0304-3940(02)00210-0},
  pmid    = {12009525},
  url     = {https://doi.org/10.1016/s0304-3940(02)00210-0}
}

@article{marambaud2002-11953314,
  author  = {Marambaud, P. and Shioi, J. and Serban, G. and Georgakopoulos, A. and Sarner, S. and Nagy, V. and Baki, L. and Wen, P. and others},
  title   = {{A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions}},
  journal = {The EMBO journal},
  year    = {2002},
  doi     = {10.1093/emboj/21.8.1948},
  pmid    = {11953314},
  url     = {https://doi.org/10.1093/emboj/21.8.1948}
}

@article{yang2002-11985878,
  author  = {Yang, L. and He, H. Y. and Zhang, X. J.},
  title   = {{Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells}},
  journal = {Neuroscience research},
  year    = {2002},
  doi     = {10.1016/s0168-0102(02)00005-6},
  pmid    = {11985878},
  url     = {https://doi.org/10.1016/s0168-0102(02)00005-6}
}

@article{fujiwara2002-11813001,
  author  = {Fujiwara, H. and Hasegawa, M. and Dohmae, N. and Kawashima, A. and Masliah, E. and Goldberg, M. S. and Shen, J. and Takio, K. and others},
  title   = {{alpha-Synuclein is phosphorylated in synucleinopathy lesions}},
  journal = {Nature cell biology},
  year    = {2002},
  doi     = {10.1038/ncb748},
  pmid    = {11813001},
  url     = {https://doi.org/10.1038/ncb748}
}

@article{wang2002-11750898,
  author  = {Wang, H. W. and Pasternak, J. F. and Kuo, H. and Ristic, H. and Lambert, M. P. and Chromy, B. and Viola, K. L. and Klein, W. L. and others},
  title   = {{Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus}},
  journal = {Brain research},
  year    = {2002},
  doi     = {10.1016/s0006-8993(01)03058-x},
  pmid    = {11750898},
  url     = {https://doi.org/10.1016/s0006-8993(01)03058-x}
}

@article{grimes2001-11527574,
  author  = {Grimes, C. A. and Jope, R. S.},
  title   = {{The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling}},
  journal = {Progress in neurobiology},
  year    = {2001},
  doi     = {10.1016/s0301-0082(01)00011-9},
  pmid    = {11527574},
  url     = {https://doi.org/10.1016/s0301-0082(01)00011-9}
}

@article{kirkitadze2001-11580253,
  author  = {Kirkitadze, M. D. and Condron, M. M. and Teplow, D. B.},
  title   = {{Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis}},
  journal = {Journal of molecular biology},
  year    = {2001},
  doi     = {10.1006/jmbi.2001.4970},
  pmid    = {11580253},
  url     = {https://doi.org/10.1006/jmbi.2001.4970}
}

@article{monsonego2001-11517335,
  author  = {Monsonego, A. and Maron, R. and Zota, V. and Selkoe, D. J. and Weiner, H. L.},
  title   = {{Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2001},
  doi     = {10.1073/pnas.191118298},
  pmid    = {11517335},
  url     = {https://doi.org/10.1073/pnas.191118298}
}

@article{chen2001-11483961,
  author  = {Chen, F. and Yu, G. and Arawaka, S. and Nishimura, M. and Kawarai, T. and Yu, H. and Tandon, A. and Supala, A. and others},
  title   = {{Nicastrin binds to membrane-tethered Notch}},
  journal = {Nature cell biology},
  year    = {2001},
  doi     = {10.1038/35087069},
  pmid    = {11483961},
  url     = {https://doi.org/10.1038/35087069}
}

@article{ermak2001-11483593,
  author  = {Ermak, G. and Morgan, T. E. and Davies, K. J.},
  title   = {{Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease}},
  journal = {The Journal of biological chemistry},
  year    = {2001},
  doi     = {10.1074/jbc.m102829200},
  pmid    = {11483593},
  url     = {https://doi.org/10.1074/jbc.m102829200}
}

@article{lauderback2001-11461977,
  author  = {Lauderback, Christopher M. and Hackett, Janna M. and Huang, Feng F. and Keller, Jeffrey N. and Szweda, Luke I. and Markesbery, William R. and Butterfield, David Allan},
  title   = {{The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42}},
  journal = {Journal of Neurochemistry},
  year    = {2001},
  doi     = {10.1046/j.1471-4159.2001.00451.x},
  pmid    = {11461977},
  url     = {https://doi.org/10.1046/j.1471-4159.2001.00451.x}
}

@article{dineley2001-11404397,
  author  = {Dineley, K. T. and Westerman, M. and Bui, D. and Bell, K. and Ashe, K. H. and Sweatt, J. D.},
  title   = {{Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2001},
  doi     = {10.1523/jneurosci.21-12-04125.2001},
  pmid    = {11404397},
  url     = {https://doi.org/10.1523/jneurosci.21-12-04125.2001}
}

@article{chishti2001-11279122,
  author  = {Chishti, M. A. and Yang, D. S. and Janus, C. and Phinney, A. L. and Horne, P. and Pearson, J. and Strome, R. and Zuker, N. and others},
  title   = {{Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695}},
  journal = {The Journal of biological chemistry},
  year    = {2001},
  doi     = {10.1074/jbc.m100710200},
  pmid    = {11279122},
  url     = {https://doi.org/10.1074/jbc.m100710200}
}

@article{chung2001-11162250,
  author  = {Chung, C. W. and Song, Y. H. and Kim, I. K. and Yoon, W. J. and Ryu, B. R. and Jo, D. G. and Woo, H. N. and Kwon, Y. K. and others},
  title   = {{Proapoptotic effects of tau cleavage product generated by caspase-3}},
  journal = {Neurobiology of disease},
  year    = {2001},
  doi     = {10.1006/nbdi.2000.0335},
  pmid    = {11162250},
  url     = {https://doi.org/10.1006/nbdi.2000.0335}
}

@article{uversky2001-11152691,
  author  = {Uversky, V. N. and Li, J. and Fink, A. L.},
  title   = {{Evidence for a partially folded intermediate in alpha-synuclein fibril formation}},
  journal = {The Journal of biological chemistry},
  year    = {2001},
  doi     = {10.1074/jbc.m010907200},
  pmid    = {11152691},
  url     = {https://doi.org/10.1074/jbc.m010907200}
}

@article{aksenov2001-11246152,
  author  = {Aksenov, M. Y. and Aksenova, M. V. and Butterfield, D. A. and Geddes, J. W. and Markesbery, W. R.},
  title   = {{Protein oxidation in the brain in Alzheimer's disease}},
  journal = {Neuroscience},
  year    = {2001},
  doi     = {10.1016/s0306-4522(00)00580-7},
  pmid    = {11246152},
  url     = {https://doi.org/10.1016/s0306-4522(00)00580-7}
}

@article{dovey2001-11145990,
  author  = {Dovey, H. F. and John, V. and Anderson, J. P. and Chen, L. Z. and de Saint Andrieu, P. and Fang, L. Y. and Freedman, S. B. and Folmer, B. and others},
  title   = {{Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain}},
  journal = {Journal of neurochemistry},
  year    = {2001},
  doi     = {10.1046/j.1471-4159.2001.00012.x},
  pmid    = {11145990},
  url     = {https://doi.org/10.1046/j.1471-4159.2001.00012.x}
}

@article{lucas2001-11226152,
  author  = {Lucas, J. J. and Hernández, F. and Gómez-Ramos, P. and Morán, M. A. and Hen, R. and Avila, J.},
  title   = {{Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice}},
  journal = {The EMBO journal},
  year    = {2001},
  doi     = {10.1093/emboj/20.1.27},
  pmid    = {11226152},
  url     = {https://doi.org/10.1093/emboj/20.1.27}
}

@article{halliwell2001-11599635,
  author  = {Halliwell, B.},
  title   = {{Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment}},
  journal = {Drugs \& aging},
  year    = {2001},
  doi     = {10.2165/00002512-200118090-00004},
  pmid    = {11599635},
  url     = {https://doi.org/10.2165/00002512-200118090-00004}
}

@article{spittaels2000-11007782,
  author  = {Spittaels, K. and Van den Haute, C. and Van Dorpe, J. and Geerts, H. and Mercken, M. and Bruynseels, K. and Lasrado, R. and Vandezande, K. and others},
  title   = {{Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice}},
  journal = {The Journal of biological chemistry},
  year    = {2000},
  doi     = {10.1074/jbc.m006219200},
  pmid    = {11007782},
  url     = {https://doi.org/10.1074/jbc.m006219200}
}

@article{kumar2000-11150636,
  author  = {Kumar, V. B. and Farr, S. A. and Flood, J. F. and Kamlesh, V. and Franko, M. and Banks, W. A. and Morley, J. E.},
  title   = {{Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice}},
  journal = {Peptides},
  year    = {2000},
  doi     = {10.1016/s0196-9781(00)00339-9},
  pmid    = {11150636},
  url     = {https://doi.org/10.1016/s0196-9781(00)00339-9}
}

@article{mattson2000-11253364,
  author  = {Mattson, M. P.},
  title   = {{Apoptosis in neurodegenerative disorders}},
  journal = {Nature reviews. Molecular cell biology},
  year    = {2000},
  doi     = {10.1038/35040009},
  pmid    = {11253364},
  url     = {https://doi.org/10.1038/35040009}
}

@article{husseman2000-11124425,
  author  = {Husseman, J. W. and Nochlin, D. and Vincent, I.},
  title   = {{Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases}},
  journal = {Neurobiology of aging},
  year    = {2000},
  doi     = {10.1016/s0197-4580(00)00221-9},
  pmid    = {11124425},
  url     = {https://doi.org/10.1016/s0197-4580(00)00221-9}
}

@article{lopez2000-11079563,
  author  = {Lopez, Mary F. and Kristal, Bruce S. and Chernokalskaya, Elena and Lazarev, Alexander V. and Shestopalov, Alexander I. and Bogdanova, Alla and Robinson, Myra H.},
  title   = {{High-throughput profiling of the mitochondrial proteome using affinity fractionation and automation}},
  journal = {Electrophoresis},
  year    = {2000},
  doi     = {10.1002/1522-2683(20001001)21:16<3427::aid-elps3427>3.0.co;2-l},
  pmid    = {11079563},
  url     = {https://doi.org/10.1002/1522-2683(20001001)21:16<3427::aid-elps3427>3.0.co;2-l}
}

@article{iijima2000-10936190,
  author  = {Iijima, K. and Ando, K. and Takeda, S. and Satoh, Y. and Seki, T. and Itohara, S. and Greengard, P. and Kirino, Y. and others},
  title   = {{Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5}},
  journal = {Journal of neurochemistry},
  year    = {2000},
  doi     = {10.1046/j.1471-4159.2000.0751085.x},
  pmid    = {10936190},
  url     = {https://doi.org/10.1046/j.1471-4159.2000.0751085.x}
}

@article{hsu2000-10934145,
  author  = {Hsu, L. J. and Sagara, Y. and Arroyo, A. and Rockenstein, E. and Sisk, A. and Mallory, M. and Wong, J. and Takenouchi, T. and others},
  title   = {{alpha-synuclein promotes mitochondrial deficit and oxidative stress}},
  journal = {The American journal of pathology},
  year    = {2000},
  doi     = {10.1016/s0002-9440(10)64553-1},
  pmid    = {10934145},
  url     = {https://doi.org/10.1016/s0002-9440(10)64553-1}
}

@article{fuentes2000-10861295,
  author  = {Fuentes, J. J. and Genescà, L. and Kingsbury, T. J. and Cunningham, K. W. and Pérez-Riba, M. and Estivill, X. and de la Luna, S.},
  title   = {{DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways}},
  journal = {Human molecular genetics},
  year    = {2000},
  doi     = {10.1093/hmg/9.11.1681},
  pmid    = {10861295},
  url     = {https://doi.org/10.1093/hmg/9.11.1681}
}

@article{schwab2000-10924763,
  author  = {Schwab, C. and DeMaggio, A. J. and Ghoshal, N. and Binder, L. I. and Kuret, J. and McGeer, P. L.},
  title   = {{Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases}},
  journal = {Neurobiology of aging},
  year    = {2000},
  doi     = {10.1016/s0197-4580(00)00110-x},
  pmid    = {10924763},
  url     = {https://doi.org/10.1016/s0197-4580(00)00110-x}
}

@article{bartus2000-10833325,
  author  = {Bartus, R. T.},
  title   = {{On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis}},
  journal = {Experimental neurology},
  year    = {2000},
  doi     = {10.1006/exnr.2000.7397},
  pmid    = {10833325},
  url     = {https://doi.org/10.1006/exnr.2000.7397}
}

@article{murphy2000-10777786,
  author  = {Murphy, D. D. and Rueter, S. M. and Trojanowski, J. Q. and Lee, V. M.},
  title   = {{Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2000},
  doi     = {10.1523/jneurosci.20-09-03214.2000},
  pmid    = {10777786},
  url     = {https://doi.org/10.1523/jneurosci.20-09-03214.2000}
}

@article{serpell2000-10781096,
  author  = {Serpell, L. C. and Berriman, J. and Jakes, R. and Goedert, M. and Crowther, R. A.},
  title   = {{Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2000},
  doi     = {10.1073/pnas.97.9.4897},
  pmid    = {10781096},
  url     = {https://doi.org/10.1073/pnas.97.9.4897}
}

@article{conway2000-10704204,
  author  = {Conway, K. A. and Harper, J. D. and Lansbury, P. T.},
  title   = {{Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid}},
  journal = {Biochemistry},
  year    = {2000},
  doi     = {10.1021/bi991447r},
  pmid    = {10704204},
  url     = {https://doi.org/10.1021/bi991447r}
}

@article{wang2000-10681545,
  author  = {Wang, H. Y. and Lee, D. H. and D'Andrea, M. R. and Peterson, P. A. and Shank, R. P. and Reitz, A. B.},
  title   = {{beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology}},
  journal = {The Journal of biological chemistry},
  year    = {2000},
  doi     = {10.1074/jbc.275.8.5626},
  pmid    = {10681545},
  url     = {https://doi.org/10.1074/jbc.275.8.5626}
}

@article{lin2000-10677483,
  author  = {Lin, X. and Koelsch, G. and Wu, S. and Downs, D. and Dashti, A. and Tang, J.},
  title   = {{Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2000},
  doi     = {10.1073/pnas.97.4.1456},
  pmid    = {10677483},
  url     = {https://doi.org/10.1073/pnas.97.4.1456}
}

@article{gouras2000-10623648,
  author  = {Gouras, G. K. and Tsai, J. and Naslund, J. and Vincent, B. and Edgar, M. and Checler, F. and Greenfield, J. P. and Haroutunian, V. and others},
  title   = {{Intraneuronal Abeta42 accumulation in human brain}},
  journal = {The American journal of pathology},
  year    = {2000},
  doi     = {10.1016/s0002-9440(10)64700-1},
  pmid    = {10623648},
  url     = {https://doi.org/10.1016/s0002-9440(10)64700-1}
}

@article{spillantini2000-11193145,
  author  = {Spillantini, M. G. and Goedert, M.},
  title   = {{The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2000},
  doi     = {10.1111/j.1749-6632.2000.tb06900.x},
  pmid    = {11193145},
  url     = {https://doi.org/10.1111/j.1749-6632.2000.tb06900.x}
}

@article{manji2000-10826666,
  author  = {Manji, Husseini K. and Moore, Gregory J. and Chen, G},
  title   = {{Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness}},
  journal = {PubMed},
  year    = {2000},
  pmid    = {10826666}
}

@article{hussain1999-10656250,
  author  = {Hussain, I. and Powell, D. and Howlett, D. R. and Tew, D. G. and Meek, T. D. and Chapman, C. and Gloger, I. S. and Murphy, K. E. and others},
  title   = {{Identification of a novel aspartic protease (Asp 2) as beta-secretase}},
  journal = {Molecular and cellular neurosciences},
  year    = {1999},
  doi     = {10.1006/mcne.1999.0811},
  pmid    = {10656250},
  url     = {https://doi.org/10.1006/mcne.1999.0811}
}

@article{huang1999-10601271,
  author  = {Huang, X. and Cuajungco, M. P. and Atwood, C. S. and Hartshorn, M. A. and Tyndall, J. D. and Hanson, G. R. and Stokes, K. C. and Leopold, M. and others},
  title   = {{Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction}},
  journal = {The Journal of biological chemistry},
  year    = {1999},
  doi     = {10.1074/jbc.274.52.37111},
  pmid    = {10601271},
  url     = {https://doi.org/10.1074/jbc.274.52.37111}
}

@article{oda1999-10594838,
  author  = {Oda, Y.},
  title   = {{Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system}},
  journal = {Pathology international},
  year    = {1999},
  doi     = {10.1046/j.1440-1827.1999.00977.x},
  pmid    = {10594838},
  url     = {https://doi.org/10.1046/j.1440-1827.1999.00977.x}
}

@article{ekinci1999-10514528,
  author  = {Ekinci, F. J. and Malik, K. U. and Shea, T. B.},
  title   = {{Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration}},
  journal = {The Journal of biological chemistry},
  year    = {1999},
  doi     = {10.1074/jbc.274.42.30322},
  pmid    = {10514528},
  url     = {https://doi.org/10.1074/jbc.274.42.30322}
}

@article{manji1999-10509176,
  author  = {Manji, H. K. and Moore, G. J. and Chen, G.},
  title   = {{Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?}},
  journal = {Biological psychiatry},
  year    = {1999},
  doi     = {10.1016/s0006-3223(99)00165-1},
  pmid    = {10509176},
  url     = {https://doi.org/10.1016/s0006-3223(99)00165-1}
}

@article{waggoner1999-10448050,
  author  = {Waggoner, D. J. and Bartnikas, T. B. and Gitlin, J. D.},
  title   = {{The role of copper in neurodegenerative disease}},
  journal = {Neurobiology of disease},
  year    = {1999},
  doi     = {10.1006/nbdi.1999.0250},
  pmid    = {10448050},
  url     = {https://doi.org/10.1006/nbdi.1999.0250}
}

@article{alvarez1999-10405156,
  author  = {Alvarez, G. and Muñoz-Montaño, JR. and Satrústegui, J. and Avila, J. and Bogónez, E. and Díaz-Nido, J.},
  title   = {{Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration}},
  journal = {FEBS letters},
  year    = {1999},
  doi     = {10.1016/s0014-5793(99)00685-7},
  pmid    = {10405156},
  url     = {https://doi.org/10.1016/s0014-5793(99)00685-7}
}

@article{huang1999-10386999,
  author  = {Huang, X. and Atwood, C. S. and Hartshorn, M. A. and Multhaup, G. and Goldstein, L. E. and Scarpa, R. C. and Cuajungco, M. P. and Gray, D. N. and others},
  title   = {{The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction}},
  journal = {Biochemistry},
  year    = {1999},
  doi     = {10.1021/bi990438f},
  pmid    = {10386999},
  url     = {https://doi.org/10.1021/bi990438f}
}

@article{hsia1999-10077666,
  author  = {Hsia, A. Y. and Masliah, E. and McConlogue, L. and Yu, G. Q. and Tatsuno, G. and Hu, K. and Kholodenko, D. and Malenka, R. C. and others},
  title   = {{Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1999},
  doi     = {10.1073/pnas.96.6.3228},
  pmid    = {10077666},
  url     = {https://doi.org/10.1073/pnas.96.6.3228}
}

@article{lammich1999-10097139,
  author  = {Lammich, S. and Kojro, E. and Postina, R. and Gilbert, S. and Pfeiffer, R. and Jasionowski, M. and Haass, C. and Fahrenholz, F.},
  title   = {{Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1999},
  doi     = {10.1073/pnas.96.7.3922},
  pmid    = {10097139},
  url     = {https://doi.org/10.1073/pnas.96.7.3922}
}

@article{ray1999-10077672,
  author  = {Ray, W. J. and Yao, M. and Nowotny, P. and Mumm, J. and Zhang, W. and Wu, J. Y. and Kopan, R. and Goate, A. M.},
  title   = {{Evidence for a physical interaction between presenilin and Notch}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1999},
  doi     = {10.1073/pnas.96.6.3263},
  pmid    = {10077672},
  url     = {https://doi.org/10.1073/pnas.96.6.3263}
}

@article{moechars1999-10037741,
  author  = {Moechars, D. and Dewachter, I. and Lorent, K. and Reversé, D. and Baekelandt, V. and Naidu, A. and Tesseur, I. and Spittaels, K. and others},
  title   = {{Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain}},
  journal = {The Journal of biological chemistry},
  year    = {1999},
  doi     = {10.1074/jbc.274.10.6483},
  pmid    = {10037741},
  url     = {https://doi.org/10.1074/jbc.274.10.6483}
}

@article{qiu1998-9830016,
  author  = {Qiu, W. Q. and Walsh, D. M. and Ye, Z. and Vekrellis, K. and Zhang, J. and Podlisny, M. B. and Rosner, M. R. and Safavi, A. and others},
  title   = {{Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation}},
  journal = {The Journal of biological chemistry},
  year    = {1998},
  doi     = {10.1074/jbc.273.49.32730},
  pmid    = {9830016},
  url     = {https://doi.org/10.1074/jbc.273.49.32730}
}

@article{trommsdorff1998-9837937,
  author  = {Trommsdorff, M. and Borg, J. P. and Margolis, B. and Herz, J.},
  title   = {{Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {1998},
  doi     = {10.1074/jbc.273.50.33556},
  pmid    = {9837937},
  url     = {https://doi.org/10.1074/jbc.273.50.33556}
}

@article{selkoe1998-9854312,
  author  = {Selkoe, D. J.},
  title   = {{The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease}},
  journal = {Trends in cell biology},
  year    = {1998},
  doi     = {10.1016/s0962-8924(98)01363-4},
  pmid    = {9854312},
  url     = {https://doi.org/10.1016/s0962-8924(98)01363-4}
}

@article{spillantini1998-9811325,
  author  = {Spillantini, M. G. and Crowther, R. A. and Kamphorst, W. and Heutink, P. and van Swieten, J. C.},
  title   = {{Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau}},
  journal = {The American journal of pathology},
  year    = {1998},
  doi     = {10.1016/s0002-9440(10)65721-5},
  pmid    = {9811325},
  url     = {https://doi.org/10.1016/s0002-9440(10)65721-5}
}

@article{takashima1998-9809590,
  author  = {Takashima, A. and Honda, T. and Yasutake, K. and Michel, G. and Murayama, O. and Murayama, M. and Ishiguro, K. and Yamaguchi, H.},
  title   = {{Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons}},
  journal = {Neuroscience research},
  year    = {1998},
  doi     = {10.1016/s0168-0102(98)00061-3},
  pmid    = {9809590},
  url     = {https://doi.org/10.1016/s0168-0102(98)00061-3}
}

@article{bales1998-9630519,
  author  = {Bales, K. R. and Du, Y. and Dodel, R. C. and Yan, G. M. and Hamilton-Byrd, E. and Paul, S. M.},
  title   = {{The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation}},
  journal = {Brain research. Molecular brain research},
  year    = {1998},
  doi     = {10.1016/s0169-328x(98)00066-7},
  pmid    = {9630519},
  url     = {https://doi.org/10.1016/s0169-328x(98)00066-7}
}

@article{baba1998-9546347,
  author  = {Baba, M. and Nakajo, S. and Tu, P. H. and Tomita, T. and Nakaya, K. and Lee, V. M. and Trojanowski, J. Q. and Iwatsubo, T.},
  title   = {{Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies}},
  journal = {The American journal of pathology},
  year    = {1998},
  pmid    = {9546347}
}

@article{davidson1998-9545270,
  author  = {Davidson, W. S. and Jonas, A. and Clayton, D. F. and George, J. M.},
  title   = {{Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes}},
  journal = {The Journal of biological chemistry},
  year    = {1998},
  doi     = {10.1074/jbc.273.16.9443},
  pmid    = {9545270},
  url     = {https://doi.org/10.1074/jbc.273.16.9443}
}

@article{lichtenthaler1997-9398269,
  author  = {Lichtenthaler, S. F. and Ida, N. and Multhaup, G. and Masters, C. L. and Beyreuther, K.},
  title   = {{Mutations in the transmembrane domain of APP altering gamma-secretase specificity}},
  journal = {Biochemistry},
  year    = {1997},
  doi     = {10.1021/bi971071m},
  pmid    = {9398269},
  url     = {https://doi.org/10.1021/bi971071m}
}

@article{mattson1997-9354812,
  author  = {Mattson, M. P.},
  title   = {{Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives}},
  journal = {Physiological reviews},
  year    = {1997},
  doi     = {10.1152/physrev.1997.77.4.1081},
  pmid    = {9354812},
  url     = {https://doi.org/10.1152/physrev.1997.77.4.1081}
}

@article{li1997-9342387,
  author  = {Li, X. and Greenwald, I.},
  title   = {{HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.22.12204},
  pmid    = {9342387},
  url     = {https://doi.org/10.1073/pnas.94.22.12204}
}

@article{hong1997-9312151,
  author  = {Hong, M. and Chen, D. C. and Klein, P. S. and Lee, V. M.},
  title   = {{Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3}},
  journal = {The Journal of biological chemistry},
  year    = {1997},
  doi     = {10.1074/jbc.272.40.25326},
  pmid    = {9312151},
  url     = {https://doi.org/10.1074/jbc.272.40.25326}
}

@article{sunde1997-9356260,
  author  = {Sunde, M. and Serpell, L. C. and Bartlam, M. and Fraser, P. E. and Pepys, M. B. and Blake, C. C.},
  title   = {{Common core structure of amyloid fibrils by synchrotron X-ray diffraction}},
  journal = {Journal of molecular biology},
  year    = {1997},
  doi     = {10.1006/jmbi.1997.1348},
  pmid    = {9356260},
  url     = {https://doi.org/10.1006/jmbi.1997.1348}
}

@article{li1997-9298903,
  author  = {Li, J. and Xu, M. and Zhou, H. and Ma, J. and Potter, H.},
  title   = {{Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation}},
  journal = {Cell},
  year    = {1997},
  doi     = {10.1016/s0092-8674(00)80356-6},
  pmid    = {9298903},
  url     = {https://doi.org/10.1016/s0092-8674(00)80356-6}
}

@article{munozmontano1997-9271202,
  author  = {Muñoz-Montaño, JR. and Moreno, F. J. and Avila, J. and Diaz-Nido, J.},
  title   = {{Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons}},
  journal = {FEBS letters},
  year    = {1997},
  doi     = {10.1016/s0014-5793(97)00688-1},
  pmid    = {9271202},
  url     = {https://doi.org/10.1016/s0014-5793(97)00688-1}
}

@article{goedert1997-9199504,
  author  = {Goedert, M. and Hasegawa, M. and Jakes, R. and Lawler, S. and Cuenda, A. and Cohen, P.},
  title   = {{Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases}},
  journal = {FEBS letters},
  year    = {1997},
  doi     = {10.1016/s0014-5793(97)00483-3},
  pmid    = {9199504},
  url     = {https://doi.org/10.1016/s0014-5793(97)00483-3}
}

@article{papasozomenos1997-9192613,
  author  = {Papasozomenos, S. C.},
  title   = {{The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.13.6612},
  pmid    = {9192613},
  url     = {https://doi.org/10.1073/pnas.94.13.6612}
}

@article{shen1997-9160754,
  author  = {Shen, J. and Bronson, R. T. and Chen, D. F. and Xia, W. and Selkoe, D. J. and Tonegawa, S.},
  title   = {{Skeletal and CNS defects in Presenilin-1-deficient mice}},
  journal = {Cell},
  year    = {1997},
  doi     = {10.1016/s0092-8674(00)80244-5},
  pmid    = {9160754},
  url     = {https://doi.org/10.1016/s0092-8674(00)80244-5}
}

@article{hardy1997-9106355,
  author  = {Hardy, J.},
  title   = {{Amyloid, the presenilins and Alzheimer's disease}},
  journal = {Trends in neurosciences},
  year    = {1997},
  doi     = {10.1016/s0166-2236(96)01030-2},
  pmid    = {9106355},
  url     = {https://doi.org/10.1016/s0166-2236(96)01030-2}
}

@article{baumeister1997-9680315,
  author  = {Baumeister, R. and Leimer, U. and Zweckbronner, I. and Jakubek, C. and Grünberg, J. and Haass, C.},
  title   = {{Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing}},
  journal = {Genes and function},
  year    = {1997},
  doi     = {10.1046/j.1365-4624.1997.00012.x},
  pmid    = {9680315},
  url     = {https://doi.org/10.1046/j.1365-4624.1997.00012.x}
}

@article{smith1997-9092586,
  author  = {Smith, M. A. and Richey Harris, P. L. and Sayre, L. M. and Beckman, J. S. and Perry, G.},
  title   = {{Widespread peroxynitrite-mediated damage in Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1997},
  doi     = {10.1523/jneurosci.17-08-02653.1997},
  pmid    = {9092586},
  url     = {https://doi.org/10.1523/jneurosci.17-08-02653.1997}
}

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  title   = {{beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease}},
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  year    = {2026},
  doi     = {10.64898/2026.10.26.761980},
  url     = {https://doi.org/10.64898/2026.10.26.761980}
}

@article{morman2026-fd4e94a3,
  author  = {Morman, C. and Agarwal, T. and Ortigosa-Pascual, L. and Knowles, T. P. and Abelein, A.},
  title   = {{Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.27.762205},
  url     = {https://doi.org/10.64898/2026.10.27.762205}
}

@article{riordan2026-da5e172b,
  author  = {Riordan, R. and Saxton, A. and Han, M. and Parrot, K. and Kraemer, B.},
  title   = {{TMEM106B C-Terminal fragment aggregation exacerbates α-synuclein and TDP-43 proteinopathy phenotypes}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.29.762961},
  url     = {https://doi.org/10.64898/2026.10.29.762961}
}

@article{elyasi2026-2817a815,
  author  = {Elyasi, L. and Chołoniewska, A. and Lutostańska, E. and Mierzwa, N. and Sulejczak, D. and Macias, M. and Szybińska, A. and Gawlik-Zawiślak, S. and others},
  title   = {{SHED-Derived Exosomes Attenuate Alzheimer's Disease Pathology in iPSC-Derived Cerebral Organoid Model}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11225065/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11225065/v1}
}

@article{paruchuri2026-a6042b4b,
  author  = {Paruchuri, S. and Sivanantharajah, L. and Mudher, A. and Chatterjee, S.},
  title   = {{Effect of Metformin on tau pathology and proteostasis in cellular and a Drosophila model of Tauopathy}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10786020/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10786020/v1}
}

@article{meng2026-02371b89,
  author  = {Meng, W. and Zhang, J. and Zhang, S. and Shi, Y. and Wang, H.},
  title   = {{Aβ42 oligomers disrupt calcium homeostasis via Piezo1 and induce neurotoxicity in differentiated SH-SY5Y cells}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11212419/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11212419/v1}
}

@article{sun2026-f4157059,
  author  = {Sun, M. N. and Vaughey, K. and Liu, B. and Guo, H. and Huganir, R. and Morris, M.},
  title   = {{Neuronal Hyperactivity Induces Tau Phosphorylation Selectively in Excitatory Pyramidal Neurons Which Contributes to GluA2 Regulation}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.26.762028},
  url     = {https://doi.org/10.64898/2026.10.26.762028}
}

@article{antic2026-8a81da8c,
  author  = {Antic, A. and Dreos, A. and Lashley, T. and Yo-Ap, S. Y. and Sander, K. and Schöll, M. and Hanrieder, J.},
  title   = {{Second-generation tau PET tracer in situ binding assessed with fluorescence imaging}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11153643/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11153643/v1}
}

@article{mohanty2026-916cd2ae,
  author  = {Mohanty, S. and Bosworth, S. and Ramaswamy, K. and Natarajan, C. and Krishnan, B.},
  title   = {{Repeated VU0155069 Treatment Is Associated with Region- and Pathological Stage-Specific Dendritic Spine Remodeling in Female 3xTg-AD Mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.26.762038},
  url     = {https://doi.org/10.64898/2026.10.26.762038}
}

@article{fluegge2026-da7070f6,
  author  = {Fluegge, K.},
  title   = {{The Filamin A Proteomic Switch: Solubility States and Cytoskeletal Dynamics Explain the Inverse Epidemiological Relationship Between Cancer and Alzheimer’s Disease}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202609.0194.v5},
  url     = {https://doi.org/10.20944/preprints202609.0194.v5}
}

@article{ujjwal2026-82239f86,
  author  = {Ujjwal, R. R. and Kumar, S. and Jain, S. and Shukla, R. and Sona, C.},
  title   = {{Precision Nanocrystal Theranostics for Neurodegenerative Proteopathies: Strategies to Cross the Blood-Brain Barrier and Target Protein Aggregation}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202610.2386.v1},
  url     = {https://doi.org/10.20944/preprints202610.2386.v1}
}

@article{sell2026-5ecfa0d2,
  author  = {Sell, J. and Loi, E. A. and Rahmati, V. and Majoros, M. and Kirmann, T. and Haselmann, H. and Stumpf, A. and Götz, T. and others},
  title   = {{Anti-GABA B receptor autoimmunity causes cognitive decline by presynaptic pathology}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.22.761036},
  url     = {https://doi.org/10.64898/2026.10.22.761036}
}

@article{munozestrada2026-3abeafdf,
  author  = {Muñoz-Estrada, J. and Jiang, Y. and Meyer, J. G.},
  title   = {{Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.20.760505},
  url     = {https://doi.org/10.64898/2026.10.20.760505}
}

@article{roy2026-9b2290e4,
  author  = {Roy, B. and Contu, V. R. and Jeziorek, M. and Friedman, W. J. and Wong, C.},
  title   = {{TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.21.760809},
  url     = {https://doi.org/10.64898/2026.10.21.760809}
}

@article{bass2026-2a77547e,
  author  = {Bass, R. and Masterson, H. V. and Chen, Y. and Xu, B.},
  title   = {{Astrocytic ablation of truncated TrkB receptors reduces amyloid plaques and prevents synaptic loss in 5xFAD mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.20.760443},
  url     = {https://doi.org/10.64898/2026.10.20.760443}
}

@article{elahi2026-5cb25560,
  author  = {Elahi, M. and Burd, I. and Yang, P. and Shen, W.},
  title   = {{Early Insulin Signaling Abnormalities and Oxidative Stress Responses in PS19 Tau Transgenic Mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.16.759692},
  url     = {https://doi.org/10.64898/2026.10.16.759692}
}

@article{upadhyay2026-fce28563,
  author  = {Upadhyay, S. and Zhang, L. and Kaur, B. and Calvo-Barreiro, L. and Teplova, M. and Gabr, M.},
  title   = {{Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.15.759511},
  url     = {https://doi.org/10.64898/2026.10.15.759511}
}

@article{antonova2026-e8cd5270,
  author  = {Antonova, D. and Gurenko, S. and Pegova, M. and Ustinova, A. and Shteynberg, G. and Chukanov, V. and Pchitskaya, E.},
  title   = {{SpineTool 2.0: A Deep Learning Platform with an Interactive User Interface for Dendritic Spine Segmentation and Morphological Analysis}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10996498/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10996498/v1}
}

@article{iftikhar2026-5f7606f8,
  author  = {Iftikhar, H. and Ejaz, M. M. and Al-Namshah, K. S. and Khan, S. and Ashraf, S. and Meer, N. and Riaz, M. and Saleem, M.},
  title   = {{Natural Sesquiterpenoids from Laggera pterodonta as bioactive Acetylcholinesterase Inhibitors: Insights from DFT, Molecular Docking, and ADMET Profiling}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11218173/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11218173/v1}
}

@article{dinakarapandian2026-cf0b65f1,
  author  = {Dinakarapandian, D. M. and Rao Sudarshan, T. and Griffin, M. N. and Ramaswamy, P. and Nguyen, P. H. and Chiu, T. and Li, C. and Kamalaldinezabadi, S. S. and others},
  title   = {{Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.14.759149},
  url     = {https://doi.org/10.64898/2026.10.14.759149}
}

@article{li2026-7bf20a60,
  author  = {Li, Y. and ploumi, C. and Volbracht, C. and Tian, W. and Kalogeraki, N. and Kitopoulou, K. and Navarro, C. C. and Li, Z. and others},
  title   = {{BNIP3L/NIX-mediated mitophagy limits Alzheimer’s disease pathology and preserves neuronal function}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.18.759942},
  url     = {https://doi.org/10.64898/2026.10.18.759942}
}

@article{wigerius2026-1229dd42,
  author  = {Wigerius, M. and Labana, P. K. and Diab, A. and Krueger, S. and Fawcett, J. P.},
  title   = {{LATS2 modulates synaptic organization and function by regulating actin dynamics}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.16.758881},
  url     = {https://doi.org/10.64898/2026.10.16.758881}
}

@article{heuer2026-8adbb044,
  author  = {Heuer, S. E. and Ahsan, F. M. and Terzioglu, G. and Misra, A. and Duong, D. and Katkar, C. and Giera, M. and van der Kant, R. and others},
  title   = {{The Alzheimer’s disease risk gene ABCA7 regulates microglial lysosomal and lipid homeostasis and promotes phagocytosis to maintain neuronal health}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.16.759681},
  url     = {https://doi.org/10.64898/2026.10.16.759681}
}

@article{kaur2026-c1b494a3,
  author  = {Kaur, B. and Abdo, A. N. and Cho, S. and Gabr, M. T.},
  title   = {{DNA-Encoded Library-Guided Discovery of a First-in-Class Molecular Glue of the NOS1AP-SCRIB Complex in Alzheimer’s Disease Patient-Derived Neurons}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.12.758423},
  url     = {https://doi.org/10.64898/2026.10.12.758423}
}

@article{basile2026-35f2647e,
  author  = {Basile, S. and Schipper, F. and Zimbone, S. and Vermorgen, S. M. and Bellia, F. and Parisi, C. and Sortino, S. and Walter, J. and others},
  title   = {{Mapping post-translational modifications across amyloid-β deposits in Alzheimer’s disease: A neuropathologic survey with in vitro functional analysis of nitration}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10769225/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10769225/v1}
}

@article{zelinger2026-a5e9790d,
  author  = {Zelinger, N. and Regev, N. and Burian, E. and Kimchy, U. and Gabay, N. and Nir, Y.},
  title   = {{Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.12.758491},
  url     = {https://doi.org/10.64898/2026.10.12.758491}
}

@article{rajic2026-c51e2b7b,
  author  = {Rajic, A. J. and Ojeda-Juarez, D. and Sarkar, D. and Sumowski, P. and Flores, S. and Pourhamzeh, M. and Soldau, K. and Pizzo, D. P. and others},
  title   = {{Reduced phosphatases and hyperphosphorylated glutamatergic receptors persist from early to late stages of prion disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.14.751571},
  url     = {https://doi.org/10.64898/2026.10.14.751571}
}

@article{jajin2026-f5a97635,
  author  = {Jajin, E. A. and Zempel, H.},
  title   = {{Integrative Multiomics Analysis Reveals a Coordinated Molecular Signature of Neuroresilience in human MAPT-knockout hiPSC-derived Neurons with relevance for Alzheimer’s and Neurodegenerative Disease}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11112521/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11112521/v1}
}

@article{bagade2026-5a084b25,
  author  = {Bagade, A. V. and Miller, R. and Dearborn, J. T. and Basore, K. and Summers, B. and Readnour, B. and Koelling, M. and O’Shea, J. and others},
  title   = {{Intrastriatal injection of amplified Lewy body dementia (LBD) fibrils in mice results in accumulation of fibrils with LBD structure and neurodegeneration}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.06.757103},
  url     = {https://doi.org/10.64898/2026.10.06.757103}
}

@article{maita2026-e1e796ab,
  author  = {Maita, N. and Kim, S. and Kajino, Y. and Kato, M.},
  title   = {{ALS-associated mutations reveal a conserved C-terminal self-assembly module in the TDP-43 low-complexity domain}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.09.756561},
  url     = {https://doi.org/10.64898/2026.10.09.756561}
}

@article{jimenezsanchez2026-0a11e557,
  author  = {Jimenez-Sanchez, M. and Lobo, P. B. and Yang, F. and Power, C. and Böken, D. and Verlin, L. and Guzman-Hernandez, R. and Cantallops-Jimenez, S. and others},
  title   = {{An astrocyte-neuron HSPB1 axis preserves lysosomal integrity and protects from tau pathology}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11192311/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11192311/v1}
}

@article{yu2026-37f5ced5,
  author  = {Yu, H. and Yang, H. and Shi, J. and Dong, W. and Wang, Z. and Meng, M. and Wang, L. and others},
  title   = {{PDE4D inhibition activates cAMP-PKA signaling to preserve mitochondrial homeostasis and prevent neuronal necroptosis in Alzheimer's disease}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11070692/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11070692/v1}
}

@article{elia2026-32eba34d,
  author  = {Elia, A. and Vazquez-Torres, R. and Carey, A. and Wolf, M. and Gade, V. R. and Alves, M. and Fossati, S.},
  title   = {{Carbonic anhydrase inhibition rescues heart function in the Tg2576 Alzheimer’s mouse model by ameliorating cardiac amyloid-β pathology and neurotrophic-signaling impairment}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.08.757731},
  url     = {https://doi.org/10.64898/2026.10.08.757731}
}

@article{abdo2026-806f3501,
  author  = {Abdo, A. N. and Cho, S. and Ge, Y. and Duan, H. and Gabr, M. T.},
  title   = {{A First-in-Class, Brain-Penetrant Small Molecule Inhibitor of the NOS1AP-Tau Interaction Rescues Tau Pathology In Vivo and Improves Cognition}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.01.755865},
  url     = {https://doi.org/10.64898/2026.10.01.755865}
}

@article{zeng2026-3cf01276,
  author  = {Zeng, X. and Abrahamson, E. E. and Balogun, W. G. and Kofler, J. and Paljug, W. R. and Pivtoraiko, V. N. and Ikonomovic, M. D. and Karikari, T. K.},
  title   = {{Brain region- and solubility-dependent proteomic signatures of neurofibrillary tangle pathology in Alzheimer’s disease}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.04.26361149},
  url     = {https://doi.org/10.64898/2026.10.04.26361149}
}

@article{napolitano2026-0d65979f,
  author  = {Napolitano, E. and Marino, C. and Grimaldi, M. and Buonocore, M. and Santoro, A. and Barbato, G. and D’Ursi, A. M.},
  title   = {{The protective effect of NGF mutant CHF6467 in SH SY5Y cells exposed to Aβ(1–42): a pharmacometabolomic approach}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.06.753538},
  url     = {https://doi.org/10.64898/2026.10.06.753538}
}

@article{dasgupta2026-cfdd9ac7,
  author  = {Dasgupta, M. and Konar, A. and Nagar, A.},
  title   = {{Magnetic Field–Enhanced Docosahexaenoic Acid Delivery for Acetylcholine Restoration in Alzheimer’s Disease: an In Silico Study}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.755051},
  url     = {https://doi.org/10.64898/2026.09.28.755051}
}

@article{goyal2026-f0e1911c,
  author  = {Goyal, G. and Palanisamy, P. and Paul, A. and Paul, S.},
  title   = {{DNA polymerase kappa supports repair-associated DNA synthesis and neuronal genome resilience}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.01.756094},
  url     = {https://doi.org/10.64898/2026.10.01.756094}
}

@article{yarlagadda2026-02a60d50,
  author  = {Yarlagadda, B. and Kumar, V.},
  title   = {{Genetically distinct neurodegenerative proteinopathies engage overlapping proteostasis components}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.753000},
  url     = {https://doi.org/10.64898/2026.09.28.753000}
}

@article{bridges2026-2036feab,
  author  = {Bridges, L. R.},
  title   = {{Repetitive RNA Is Present in Prion-Infected Mouse Brains}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202610.0105.v1},
  url     = {https://doi.org/10.20944/preprints202610.0105.v1}
}

@article{pandey2026-72021b1f,
  author  = {Pandey, R. and Olabi, T. and Lee, M. and Urbanc, B.},
  title   = {{Distinct Aβ40 and Aβ42 co-assembly pathways with free lipids: Experiment-driven MD study}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.755027},
  url     = {https://doi.org/10.64898/2026.09.28.755027}
}

@article{kelberman2026-122cfbbc,
  author  = {Kelberman, M. A. and Winther, K. E. and Ibrahiem, R. E. and Albregts, E. G. and Pardasani, M. and Watanabe, Y. L. and Donaldson, Z. R.},
  title   = {{Hypothalamic tau P301L pathology disrupts pair bonding in monogamous prairie voles}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.755178},
  url     = {https://doi.org/10.64898/2026.09.28.755178}
}

@article{saito2026-92b1327f,
  author  = {Saito, M. L. and Saito, M. R.},
  title   = {{T1R2/T1R3 Identified as the Aβ Receptor: A New Mechanism Linking Aβ42/40 Ratio to Neuronal Hyperexcitability in Alzheimer’s Disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.25.754367},
  url     = {https://doi.org/10.64898/2026.09.25.754367}
}

@article{masry2026-9fa132e6,
  author  = {Masry, B. and Shahin, A. and Malek, Z. S.},
  title   = {{A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle–slow-oscillation decoupling cascade dissociates amyloid and tau}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.21.753161},
  url     = {https://doi.org/10.64898/2026.09.21.753161}
}

@article{rao2026-29a49622,
  author  = {Rao, R. and Kar, V. and Webb, B.},
  title   = {{In silico design and physicochemical characterisation of a dual-action intranasal nanoparticle formulation for Alzheimer’s disease}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10822803/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10822803/v1}
}

@article{murthygowda2026-8155c39b,
  author  = {MurthyGowda, S. and Huyghue, K. and Castillo, B. and Gugala, F. and Li, W. and Dubnau, J.},
  title   = {{Early life social isolation primes flies for more rapid TDP-43 dependent neurodegeneration later in life}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.23.753732},
  url     = {https://doi.org/10.64898/2026.09.23.753732}
}

@article{meena2026-5c2dbb27,
  author  = {Meena, R. K. and Duddu, A. S. and Jolly, M. K. and Prasad, H.},
  title   = {{Endosomal pH Triggers Amyloid β Oligomerization and Maladaptive Phenotypic Plasticity in Alzheimers Disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.23.752284},
  url     = {https://doi.org/10.64898/2026.09.23.752284}
}

@article{verma2026-b6245a7d,
  author  = {Verma, B. and Cording, A. and Blincowe, L. and Rice, S. and Vine, H. and Wainwright, S. M. and Goberdhan, D. C. I. and Wilson, C.},
  title   = {{Cofilin Suppresses Tau-Induced Defects in Dense-Core Granule Formation and Aβ-Induced Neurodegeneration}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.22.753479},
  url     = {https://doi.org/10.64898/2026.09.22.753479}
}

@article{jin2026-3ef10c5a,
  author  = {Jin, B. and Li, Z. and Hao, Y. and Kowal, I. and Epstein, J. and Santiana, M. and Weller, C. A. and Nalls, M. A. and others},
  title   = {{Profiling of Aggregated Amyloid β42-induced Proteomic Alterations in KOLF2.1J Induced Pluripotent Stem Cell-derived Neurons}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.20.753014},
  url     = {https://doi.org/10.64898/2026.09.20.753014}
}

@article{crowe2026-08036707,
  author  = {Crowe, A.},
  title   = {{Evidence of P-glycoprotein mediated bidirectional transport of beta-amyloid (Ab40 and Ab42) through CLEFF4 cells}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10926932/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10926932/v1}
}

@article{sonkodi2026-22979f3e,
  author  = {Sonkodi, B.},
  title   = {{Parkinson’s Disease Onset in Light of Acquired Irreversible Piezo2 Channelopathy}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202609.1965.v1},
  url     = {https://doi.org/10.20944/preprints202609.1965.v1}
}

@article{alhadrami2026-c6d8e695,
  author  = {Alhadrami, M. and Gill, E. and Perks, C. M. and Barker, R. M.},
  title   = {{Amyloid precursor protein: an Achilles’ heel to exploit in the treatment of prostate cancer}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.21.752657},
  url     = {https://doi.org/10.64898/2026.09.21.752657}
}

@article{cording2026-f93c5f98,
  author  = {Cording, A. and Verma, B. and Arous, A. and Rice, S. and Vine, H. and Blincowe, L. and Wainwright, S. M. and Singh, P. J. and others},
  title   = {{Rab11-exosome biogenesis regulators mediate Aβ-induced intercellular propagation of endolysosomal trafficking defects and neurodegeneration}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.17.752336},
  url     = {https://doi.org/10.64898/2026.09.17.752336}
}

@article{suissa2026-2f103e54,
  author  = {Suissa, M. V. and Koutures, A. and Harker, S. and Vaughan, B. and Kfir, J. and Bhat, A. and Shihabi, R. and Dewal, M. B. and others},
  title   = {{Autonomous AI-Driven Nanoscale Spatial Mapping Reveals Novel Targets and Ternary Architectures in 5xFAD Alzheimer's Disease Model}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.09.750448},
  url     = {https://doi.org/10.64898/2026.09.09.750448}
}

@article{patil2026-039d6010,
  author  = {Patil, S. P. and Kuehn, B. and Schlosser, R. and Samohod, J.},
  title   = {{Discovery of Bavachin as a Dual Trk-A/Trk-B Agonist via Integrated Computational Screening and Experimental Validation}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.10.750759},
  url     = {https://doi.org/10.64898/2026.09.10.750759}
}

@article{makhlouf2026-4949dd36,
  author  = {Makhlouf, H. and Dorigatti, A. O. and Hernandez, S. and de Rosa, N. and Miller, L. and Hussong, S. and Holstein, D. and Lechleiter, J. and others},
  title   = {{Soluble pathogenic tau transmission to astrocytes drives cellular senescence and neurovascular uncoupling in a model of Alzheimer’s tauopathy}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.08.750215},
  url     = {https://doi.org/10.64898/2026.09.08.750215}
}

@article{vandenheuvel2026-b5f4b141,
  author  = {van den Heuvel, L. and Stähli, D. A. and Radecke, J. and Daraspe, J. and Shafiei, N. and Lewis, A. J. and van de Berg, W. D. J. and Genoud, C. and others},
  title   = {{Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human Brain}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.04.749518},
  url     = {https://doi.org/10.64898/2026.09.04.749518}
}

@article{calligaro2026-2135ac46,
  author  = {Calligaro, H. and Khov, B. and Noel, K. and Glina, A. and van Rosmalen, L. and Ramasamy, R. and Li, Y. and Lam, M. T. Y. and others},
  title   = {{The circadian system is affected by Alzheimer’s disease independently from amyloid beta deposits}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.25.744599},
  url     = {https://doi.org/10.64898/2026.08.25.744599}
}

@article{li2026-42c376bd,
  author  = {Li, R. and He, S. and Gruber, D. and Krämer, M. and Stürmer, A. and Hasler, R. and Kleber, C. and Knoll, W. and others},
  title   = {{A gFET-based Sensor Equipped with a Focused Post-SELEX Aptamer Library for Specific Quantification of the Hormone-like Anti-Aging Protein Klotho in Human Serum}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10661096/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10661096/v1}
}

@article{tian2026-47e82ed4,
  author  = {Tian, M. and Zhu, X. and Lei, Z. and Lu, Y. and Mo, L. and Tan, J.},
  title   = {{Taulipro rescues mitochondrial dysfunction and inhibits cGAS–STING neuroinflammation in Aβ-driven Alzheimer's disease models}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10416296/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10416296/v1}
}

@article{simzer2026-c4ebe54d,
  author  = {Simzer, E. and McGeachan, R. I. and Tulloch, J. and Tzioras, M. and Smith, C. and Nicoll, J. A. and Boche, D. and Spires-Jones, T. L.},
  title   = {{Active amyloid beta immunization ameliorates synapse loss and phosphorylated-tau accumulation around remaining plaques for up to 14 years after treatment}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.10.26359862},
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}

@article{seerleynolan2026-6e1d26a2,
  author  = {Seerley Nolan, A. L. and McElroy, S. D. and Mace, A. A. and Grindeland Panter, A. L.},
  title   = {{A New Frontier in CWD Detection: Antemortem Plasma Biomarkers and Behavioral Profiling in Transgenic Mouse Models}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.04.742870},
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}

@article{valledor2026-f87dce03,
  author  = {Valledor, M. and Smith, K. and Lawrence, J. B. and Sosa, L. J.},
  title   = {{APP Dosage and Extracellular Domain Variants Drive Distinct Defects in Neurogenesis modeled in Down Syndrome iPS cells}},
  journal = {bioRxiv},
  year    = {2026},
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  url     = {https://doi.org/10.64898/2026.08.05.742240}
}

@article{yadav2026-d0da0ad5,
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  title   = {{Early Amyloid-β Toxicity Disrupts Nervous System Connectivity During Aging in Caenorhabditis elegans}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.27.740981},
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@article{mahmoudi2026-7fb049ee,
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  title   = {{Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.25.740710},
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}

@article{rathi2026-5bb621f8,
  author  = {Rathi, R.},
  title   = {{Computational Screening of 1,348 FDA-Approved Drugs as Potential BACE1 Inhibitors for Alzheimer's Disease Drug Repurposing}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10484841/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10484841/v1}
}

@article{kron2026-9fc2d73f,
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  title   = {{Chronic orexin receptor antagonism is associated with rescued sleep and agitation-like behaviour in tau transgenic PS19 mice, but sex-dependently improved cognition}},
  journal = {Authorea Preprints},
  year    = {2026},
  doi     = {10.22541/authorea.15006549/v1},
  url     = {https://doi.org/10.22541/authorea.15006549/v1}
}

@article{morse2026-aa1d8498,
  author  = {Morse, S. V. and Rohfleisch, L. and Geoghegan, G. and Sujarittam, K. and Rimer, S. and Chan, T. G. and Kench, T. and Pereira, M. A. and others},
  title   = {{Cobalt-Based Drug Delivery to the Brain using Rapid Short-Pulses of Focused Ultrasound and Microbubbles reduces Aβ aggregation in 5XFAD mice}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10332117/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10332117/v1}
}

@article{fuentessantamaria2026-b3cc5f32,
  author  = {Fuentes-Santamaría, V. and Alvarado, J. C. and Benitez, Z. and Gabaldón-Ull, M. C. and Saido, T. C. and Saito, T. and Lenarz, T. and Juiz, J. M.},
  title   = {{Alzheimer disease β-amyloid pathology accelerates age-related hearing loss: evidence from App NL-F “knock-in” mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.05.25.727095},
  url     = {https://doi.org/10.64898/2026.05.25.727095}
}

@article{west2026-7b94cbdf,
  author  = {West, N. R. and Lindberg, M. F. and Dairou, J. and MacGregor, S. and Puthireddy, S. and Meijer, L. and Bhattacharyya, A.},
  title   = {{Leucettinib-21 decreases dosage effects of DYRK1A in human trisomy 21 iPSC-derived neural cells}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.02.05.704014},
  url     = {https://doi.org/10.64898/2026.02.05.704014}
}

@article{karim2026-c556b929,
  author  = {Karim, F. and Biju, A. P. and Liang, C. and Santos, C. J. and Rajarethenam, M. and Mukherjee, J.},
  title   = {{Evaluation of [18F]MK-6240 binding to tau protein in postmortem human brains of Down syndrome and Alzheimer’s disease and assessment of off-target (non-tau) binding}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-8463304/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-8463304/v1}
}

@article{pittonrissardo2025-7b94959b,
  author  = {Pitton Rissardo, J. and Fornari Caprara, A. L.},
  title   = {{A Biophysical Framework for Neurodegeneration: Prioritizing Protein Homeostasis Over Aggregate Toxicity}},
  journal = {Preprints.org},
  year    = {2025},
  doi     = {10.20944/preprints202512.2722.v1},
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@article{gupta2025-20b76129,
  author  = {GUPTA, A. and Liu, R. and Keely, D. and Sunderman, V. and Tak, Y. and Konstantoulea, K. and Terpack, S. and White, C. L. and others},
  title   = {{Conformation-based detection of tau seeds with a novel VHH}},
  journal = {Research Square},
  year    = {2025},
  doi     = {10.21203/rs.3.rs-8274351/v1},
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@article{senapati2025-41377958,
  author  = {Senapati, Sudipta and Sciortino, Alessia and Samples, Madison and Shchankin, Nikita and Zhao, Yingxin and Montalbano, Mauro and Kayed, Rakez},
  title   = {{Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of Synucleinopathy}},
  journal = {Research square},
  year    = {2025},
  doi     = {10.21203/rs.3.rs-8166445/v1},
  pmid    = {41377958},
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@article{pirhanov2025-41383776,
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  title   = {{Nanobodies targeting hnRNPA2/B1 and tau}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.1101/2025.11.21.689763},
  pmid    = {41383776},
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@article{zamoraloyarte2025-1f2cbfa0,
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  title   = {{Generation of a recombinant GST-Tau antigen for indirect ELISA in evaluating Alzheimer’s disease vaccines}},
  journal = {bioRxiv},
  year    = {2025},
  doi     = {10.1101/2025.09.18.676867},
  url     = {https://doi.org/10.1101/2025.09.18.676867}
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@article{wu2025-293b5940,
  author  = {Wu, H. and Hou, Y. and Feng, X. and Xia, X. and Yu, X. and Kong, W.},
  title   = {{mRNA vaccine platform demonstrates potent immunotherapeutic targeting of amyloid-β and tau pathologies in Alzheimer's disease}},
  journal = {Research Square},
  year    = {2025},
  doi     = {10.21203/rs.3.rs-7514957/v1},
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@article{patel2025-c5fbe4fa,
  author  = {Patel, D. and Rakowiecki, K. and Lazarov, O.},
  title   = {{Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer’s Disease phenotypes associated with Down Syndrome}},
  journal = {bioRxiv},
  year    = {2025},
  doi     = {10.1101/2025.07.30.667706},
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@article{jiang2025-2657e87d,
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  title   = {{Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies}},
  journal = {bioRxiv},
  year    = {2025},
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@article{mendis2025-f4484f4b,
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  year    = {2025},
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  title   = {{Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease}},
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  year    = {2024},
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