% alzhub.org library filter % Source: https://alzhub.org/research?journal=bioRxiv % 217 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{karim2026-9885f5da, author = {Karim, F. and Chavez-Jacobo, N. P. and Liang, C. and Head, E. and Mukherjee, J.}, title = {{Down syndrome postmortem brains exhibit reduction in [ 18 F]nifene binding to α4β2* nicotinic acetylcholinergic receptors}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.09.750420}, url = {https://doi.org/10.64898/2026.09.09.750420} } @article{marti2026-32527300, author = {Marti, M. B. and Morrison, S. D. and Pars, S. and Al-mhanawi, B. and Noakes, P. G. and Wolvetang, E. J. and Shaker, M. R.}, title = {{Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.27.747500}, url = {https://doi.org/10.64898/2026.08.27.747500} } @article{gujjala2024-77053260, author = {Gujjala, V. A. and Klimek, I. and Abyadeh, M. and Tyshkovskiy, A. and Oz, N. and Castro, J. P. and Gladyshev, V. N. and Newton, J. and others}, title = {{A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer’s disease and aging research}}, journal = {bioRxiv}, year = {2024}, doi = {10.1101/2024.04.19.590328}, url = {https://doi.org/10.1101/2024.04.19.590328} } @article{perry2024-ed68acdf, author = {Perry, J. C. and Vann, S. D.}, title = {{Reduction in neurons immunoreactive for parvalbumin, calretinin and calbindin in the anteroventral thalamic nuclei of individuals with Down syndrome}}, journal = {bioRxiv}, year = {2024}, doi = {10.1101/2024.02.01.578360}, url = {https://doi.org/10.1101/2024.02.01.578360} } @article{czerminski2022-be7d48c0, author = {Czerminski, J. T. and King, O. D. and Lawrence, J. B.}, title = {{Modeling Down syndrome neurodevelopment with isogenic cerebral organoids}}, journal = {bioRxiv}, year = {2022}, doi = {10.1101/2022.05.25.493459}, url = {https://doi.org/10.1101/2022.05.25.493459} } @article{viard2019-021316a1, author = {Viard, J. and Loe-Mie, Y. and Daudin, R. and Khelfaoui, M. and Plancon, C. and Boland, A. and Tejedor, F. and Huganir, R. L. and others}, title = {{Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease}}, journal = {bioRxiv}, year = {2019}, doi = {10.1101/2019.12.11.872606}, url = {https://doi.org/10.1101/2019.12.11.872606} } @article{butler2025-35ab99e8, author = {Butler, P. M. and Francis, A. and Meunier, A. L. and Anderson, A. K. and Hennessey, E. L. and Miller, M. B. and Lemere, C. A. and Selkoe, D. J. and others}, title = {{Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain}}, journal = {bioRxiv}, year = {2025}, doi = {10.1101/2025.05.20.654902}, url = {https://doi.org/10.1101/2025.05.20.654902} } @article{valay2026-d4bf18aa, author = {Valay, L. and Kasri, A. and Fontaine, V. and Camporesi, E. and Bigou, S. and Brinkmalm, G. and Piotrowska, D. and Dancette, L. and others}, title = {{Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.29.762815}, url = {https://doi.org/10.64898/2026.10.29.762815} } @article{tsoran2026-5c090ac9, author = {Tsoran, L. and Rom, Y. and Taha, A. and Shwaiky, Y. and Attal, F. and Naveh, N. and Levy, Y. and Adam, M. and others}, title = {{Concurrent cognitive, behavioral and systemic physiological features mark preclinical Alzheimer's disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.761827}, url = {https://doi.org/10.64898/2026.10.26.761827} } @article{kaur2026-c1b494a3, author = {Kaur, B. and Abdo, A. N. and Cho, S. and Gabr, M. T.}, title = {{DNA-Encoded Library-Guided Discovery of a First-in-Class Molecular Glue of the NOS1AP-SCRIB Complex in Alzheimer’s Disease Patient-Derived Neurons}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.12.758423}, url = {https://doi.org/10.64898/2026.10.12.758423} } @article{abdo2026-806f3501, author = {Abdo, A. N. and Cho, S. and Ge, Y. and Duan, H. and Gabr, M. T.}, title = {{A First-in-Class, Brain-Penetrant Small Molecule Inhibitor of the NOS1AP-Tau Interaction Rescues Tau Pathology In Vivo and Improves Cognition}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.01.755865}, url = {https://doi.org/10.64898/2026.10.01.755865} } @article{sharma2026-c554220d, author = {Sharma, A. and Aylar, D. and Lapin, D. and Marambaud, P. and Wang, P.}, title = {{Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.18.752724}, url = {https://doi.org/10.64898/2026.09.18.752724} } @article{saito2026-92b1327f, author = {Saito, M. L. and Saito, M. R.}, title = {{T1R2/T1R3 Identified as the Aβ Receptor: A New Mechanism Linking Aβ42/40 Ratio to Neuronal Hyperexcitability in Alzheimer’s Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.25.754367}, url = {https://doi.org/10.64898/2026.09.25.754367} } @article{huang2026-23883748, author = {Huang, Y. and Toga, A. W. and Zhao, L. and {the Alzheimer’s Disease Neuroimaging Initiative}}, title = {{White Matter Slow-4 fALFF as a Complementary Marker in the Multimodal Alzheimer’s Disease Biomarker Landscape}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.17.752468}, url = {https://doi.org/10.64898/2026.09.17.752468} } @article{mulholland2026-718be203, author = {Mulholland, M. and Magden, E. R. and Achorn, A. M. and Mangin, J. and Hopkins, W. D.}, title = {{Clinically Relevant Biomarkers of Alzheimer's Disease Are Associated with Age and Cortical Atrophy in Chimpanzees ( Pan troglodytes )}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.12.744516}, url = {https://doi.org/10.64898/2026.08.12.744516} } @article{seerleynolan2026-6e1d26a2, author = {Seerley Nolan, A. L. and McElroy, S. D. and Mace, A. A. and Grindeland Panter, A. L.}, title = {{A New Frontier in CWD Detection: Antemortem Plasma Biomarkers and Behavioral Profiling in Transgenic Mouse Models}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.04.742870}, url = {https://doi.org/10.64898/2026.08.04.742870} } @article{subbulakshmi2026-11572edc, author = {Subbulakshmi, S. and Park, J. and Rathmann-Bloch, J. and Ward, T. and Cheng, G. L. and Miller, D. S. and Schwartz, S. T. and Sheng, J. and others}, title = {{Dissociable structural and molecular pathways of age-related variability in sustained attention}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.06.29.735429}, url = {https://doi.org/10.64898/2026.06.29.735429} } @article{upadhyay2026-fce28563, author = {Upadhyay, S. and Zhang, L. and Kaur, B. and Calvo-Barreiro, L. and Teplova, M. and Gabr, M.}, title = {{Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.15.759511}, url = {https://doi.org/10.64898/2026.10.15.759511} } @article{choi2026-a92521b4, author = {Choi, M. and Kim, K. and Kim, I. and Jung, M. K. and Kim, D.}, title = {{Brain-wide Cerebrospinal Fluid Recirculation Collapse in Alzheimer’s Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.01.755971}, url = {https://doi.org/10.64898/2026.10.01.755971} } @article{saloner2026-b2999acb, author = {Saloner, R. and Cornelis, L. and Downer, J. and Dietz, C. and Chan, B. and Hughes, M. and Olzinski, M. and Cobigo, Y. and others}, title = {{Large-scale cerebrospinal fluid proteomics identifies diagnostic biomarker candidates across the clinico-pathological continuum of frontotemporal lobar degeneration}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.29.755483}, url = {https://doi.org/10.64898/2026.09.29.755483} } @article{brown2026-33c99656, author = {Brown, B. R. P. and Li, X. and Grasty, M. R. and Miranker, A. D. and Gürsoy, G.}, title = {{Integrating CSF and EV Proteomes Enhances Biomarker Discovery by Capturing Shared Variation Across Compartments}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.30.754912}, url = {https://doi.org/10.64898/2026.09.30.754912} } @article{jin2026-3ef10c5a, author = {Jin, B. and Li, Z. and Hao, Y. and Kowal, I. and Epstein, J. and Santiana, M. and Weller, C. A. and Nalls, M. A. and others}, title = {{Profiling of Aggregated Amyloid β42-induced Proteomic Alterations in KOLF2.1J Induced Pluripotent Stem Cell-derived Neurons}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.20.753014}, url = {https://doi.org/10.64898/2026.09.20.753014} } @article{bagari2026-9cae63ba, author = {Ba Gari, I. and Zhu, A. and Bhatt, R. R. and Nir, T. M. and Jahanshad, N.}, title = {{Regional choroid plexus calcifications and their associations with aging, brain structure, and disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.10.750525}, url = {https://doi.org/10.64898/2026.09.10.750525} } @article{voloviceva2026-7b70684b, author = {Voloviceva, E. and Goetze, S. and Hausler, S. and Abukar, S. H. and Jagels, A. and Othman, A. and von Eckardstein, A. and Robert, J.}, title = {{The protein and lipid compositions of brain apolipoprotein E particles are cell type-specific}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.07.749850}, url = {https://doi.org/10.64898/2026.09.07.749850} } @article{sangeet2026-ef7d1dde, author = {Sangeet, S. and Phillips, C. L. and Hoyos, C. M. and D’Rozario, A. L. and Lucey, B. P. and Postnova, S.}, title = {{Quantitative Modelling of Amyloid-β Dynamics in Brain, CSF, and Plasma During Sleep and Wakefulness}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.07.749991}, url = {https://doi.org/10.64898/2026.09.07.749991} } @article{gray2026-95944ba3, author = {Gray, C. and Hu, K. and Tse, D. H. and Dieterle, K. and Simpson, S. and Ruhl, T. and Duff, K. and Kim, D. and others}, title = {{High frame rate in vivo two-photon microscopy to quantify murine cerebrospinal fluid flow heterogeneity}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.04.749497}, url = {https://doi.org/10.64898/2026.09.04.749497} } @article{dekleijn2026-4fee9899, author = {de Kleijn, K. and Weller, S. and Klaassen, R. and Koopmans, F. and Smit, A. and Wijdeven, R.}, title = {{The TREM-receptor family interactome in the human brain}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.28.762136}, url = {https://doi.org/10.64898/2026.10.28.762136} } @article{shi2026-06f6a958, author = {Shi, C. H. and Zhu, B. and Pina-Crespo, J. and Chen, W. N. and Vo, G. V. and Huang, H. and Yip, K. Y. and Huang, T. Y.}, title = {{Spatial proximity to AD pathology defines cell-type and genotype-specific characteristics in human AD hippocampus}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.15.759523}, url = {https://doi.org/10.64898/2026.10.15.759523} } @article{lee2026-ce9e4ee2, author = {Lee, H. and Peppler, G. B. and Sewell, M. and Münch, A. and Podleśny-Drabiniok, A. and Kim, J. J. and Orrick, J. and Marcora, E. and others}, title = {{A rapid, genetically-tractable human iPSC-derived model for studying tissue-resident macrophage biology in Alzheimer’s and other diseases}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.08.757653}, url = {https://doi.org/10.64898/2026.10.08.757653} } @article{lannetteweimann2026-70beeb19, author = {Lannette-Weimann, N. and Huyvaert, M. and Limoge, F. and Lemaire, M. and Gao, V. and Maurier, F. and Guyot, K. and Henocq, C. and others}, title = {{The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.761842}, url = {https://doi.org/10.64898/2026.10.26.761842} } @article{lu2026-20c913a6, author = {Lu, S. and Enduru, N. and Citu, C. and Tung, C. and Zhao, Z.}, title = {{Single-Nucleus Profiling Reveals Neuronal Metabolic Collapse During the Transition to Alzheimer’s Disease Dementia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.761376}, url = {https://doi.org/10.64898/2026.10.26.761376} } @article{danhash2026-f606cf98, author = {Danhash, E. P. and Verbeck, A. C. and Iyer, A. K. and Karch, C. M.}, title = {{Ms4a4a loss preferentially remodels microglia with limited, compartment-specific effects across central and peripheral immune compartments in 5xFAD mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.762005}, url = {https://doi.org/10.64898/2026.10.26.762005} } @article{dominicus2026-a6b33c77, author = {Dominicus, C. and Peretti, D. and Rodschinka, G. and Ogden, S. and Steer, J. and Salazar, M. L. and Miraki Feriz, A. and Feng, C. and others}, title = {{Transcriptomic and phenotypic characterization of Alzheimer’s disease risk genes in neurons and astrocytes highlights shared and cell type specific cellular mechanisms}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.13.758778}, url = {https://doi.org/10.64898/2026.10.13.758778} } @article{petrican2026-3c867269, author = {Petrican, R. and Fornito, A. and John, A. and Pendered, S.}, title = {{Regional similarity to male-typical brain architecture links childhood ADHD to neurophysiological aging in later adulthood}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.27.754764}, url = {https://doi.org/10.64898/2026.09.27.754764} } @article{babtie2026-bc258973, author = {Babtie, A. C. and Blake, G. E. T. and {Youth-GEMs Consortium} and Clifton, N. E. and Hawes, T. and Barroso, I. and Mill, J.}, title = {{A single-nuclei multiomics resource across four brain regions prioritises human neural cell types influencing brain-related traits}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.24.754059}, url = {https://doi.org/10.64898/2026.09.24.754059} } @article{dattilo2026-13f2bc93, author = {Dattilo, D. and Pellegrini, F. and Barattucci, S. and Brown, A. and Vargas, J. N. S. and Gatt, A. and Morrie, R. and Miller, G. and others}, title = {{TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.17.752342}, url = {https://doi.org/10.64898/2026.09.17.752342} } @article{reed2026-9f5b4c53, author = {Reed, X. and Acri, D. J. and Beilina, A. and Ding, J. and Saez-Atienzar, S. and Kaileh, M. and Bromberek, S. and Hu, F. and others}, title = {{Integration of cell-specific gene expression and chromatin accessibility facilitates localization of neurodegenerative risk in microglia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.15.751821}, url = {https://doi.org/10.64898/2026.09.15.751821} } @article{leon2026-1faaf0d8, author = {Leon, J. and Yoshinaga, S. and Koya, I. and Palafox, G. and Ando, Y. and Kubo, K. and Moody, J. and Takao, M. and others}, title = {{DAP12-deficient microglia adopt a TREM2-independent antigen-presenting state with a glial-to-neuronal cascade in Nasu-Hakola disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.07.757387}, url = {https://doi.org/10.64898/2026.10.07.757387} } @article{anand2026-d39ea5ab, author = {Anand, A. and Natarajan, E.}, title = {{Cross-Dataset Reanalysis of Mouse Alzheimer Disease Single-Cell RNA-Sequencing Data Reveals a Reproducible Innate Immune Activation Signature}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.30.755581}, url = {https://doi.org/10.64898/2026.09.30.755581} } @article{lin2026-703e2eb0, author = {Lin, D. and Atkinson, JR. and Wu, W. and Chen, M. and Jayasekara, S. and Segal, B. M. and Ma, A. and Gao, J.}, title = {{A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.16.752098}, url = {https://doi.org/10.64898/2026.09.16.752098} } @article{antonbarros2026-0ceb195a, author = {Antón-Barros, C. and Villarejo-Zori, B. and Carmona-Lorenzo, S. and Barbero-Paredes, J. M. and González-Díaz, D. and Uceda, M. and Fernàndez-Bernal, A. and Portero-Otín, M. and others}, title = {{A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.10.750647}, url = {https://doi.org/10.64898/2026.09.10.750647} } @article{lin2026-160e62d4, author = {Lin, S. and Li, M. and Wang, S. and Li, E. and Sun, H. and Li, L.}, title = {{Public-Data Reanalysis Links MS4A4A to M2-like Human Myeloid States and Supports a Predicted Four-Pass Transmembrane Fold}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.19.745820}, url = {https://doi.org/10.64898/2026.08.19.745820} } @article{kuhnau2026-4fd9d702, author = {Kuhnau, L. and Jimenez, G. A. and Hack, W. and Varada, S. and Gladen-Kolarsky, N. and Kim, S. and Klein, F. and Banerji, T. and others}, title = {{The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.31.741838}, url = {https://doi.org/10.64898/2026.07.31.741838} } @article{krunic2026-ec5a997c, author = {Krunic, A. and Umesh Ganesh, N. and Coskun, U. and Brennan, W. and Patel, C. and Joshi, O. and Lee, J. and Gu, T. S. and others}, title = {{MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer’s Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.20.738977}, url = {https://doi.org/10.64898/2026.07.20.738977} } @article{srikanth2026-e12d5e2b, author = {Srikanth, M. and Jiang, S. and Wellman, S. M. and Sarkar, S. and Lorman, D. E. and Lantin, T. and Runyan, A. M. and Kumar, M. and others}, title = {{Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.14.738427}, url = {https://doi.org/10.64898/2026.07.14.738427} } @article{balistreri2026-20d3f448, author = {Balistreri, A. and Gomulinski, M. and Chapman, M. R. and Kelly, J. W.}, title = {{The Microglial Protein sTREM2 Inhibits the Bacterial Functional Amyloid CsgA and Suppresses Amyloid-Dependent Biofilm Formation}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.03.736422}, url = {https://doi.org/10.64898/2026.07.03.736422} } @article{fang2026-7e17688f, author = {Fang, J. I. and Lehmann, L. and Prater, K. E. and Barker-Haliski, M.}, title = {{Pregnancy History and Loss of Normal PSEN2 Function Impact Female Late-Life Cognitive Processing, Inhibitory Signaling, and Gliosis}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.28.762624}, url = {https://doi.org/10.64898/2026.10.28.762624} } @article{munozestrada2026-3abeafdf, author = {Muñoz-Estrada, J. and Jiang, Y. and Meyer, J. G.}, title = {{Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.20.760505}, url = {https://doi.org/10.64898/2026.10.20.760505} } @article{riaz2026-1fe6b0f9, author = {Riaz, H. A. and Soman, S. K. and Devlin, J. F. and Kumar, G. and Lee, Y. and Morrow, E. M.}, title = {{Longitudinal single-cell transcriptional profiling identifies dynamic neurodegenerative mechanisms in Christianson Syndrome rat}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.14.756427}, url = {https://doi.org/10.64898/2026.10.14.756427} } @article{cox2026-d503604f, author = {Cox, J. E. and Poljanska, E. and Ray, S. and Forsgren, M. and Ko, S. and Swiergiel, P. and Wright, Z. and Thomas, M. A. and others}, title = {{Female microglia show heightened responses to aging and amyloid pathology in mice and humans}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.13.758897}, url = {https://doi.org/10.64898/2026.10.13.758897} } @article{kumar2026-ed611fa0, author = {Kumar, A. and Zhang, J. and Harvey, J. and Guenter, R. and Chkheidze, R. and Sethu, P. and Beck, A. W. and Ren, B.}, title = {{Endothelial CD36 links arteriolar remodeling to metabolic and immune alterations in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.13.758947}, url = {https://doi.org/10.64898/2026.10.13.758947} } @article{moselakgomo2026-7cc2f407, author = {Moselakgomo, N. and Mthethwa, W. and Van Zyl, S. and Gryzenhout, M. and Kemp, G. and Ntsapi-Combrink, C.}, title = {{The modulatory effects of Hericium erinaceus and donepezil on amyloid accumulation and autophagy-associated clearance in Aβ 1-42 -induced N2a cells}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.06.757182}, url = {https://doi.org/10.64898/2026.10.06.757182} } @article{moallem2026-2631138c, author = {Moallem, E. Z. and Bruntz, R. C. and Cox, M. F. and Bytyqi, L. and Roberts, T. K. and Patel, S. P. and Macheda, T. and Roberts, K. N. and others}, title = {{Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.29.755475}, url = {https://doi.org/10.64898/2026.09.29.755475} } @article{verma2026-b6245a7d, author = {Verma, B. and Cording, A. and Blincowe, L. and Rice, S. and Vine, H. and Wainwright, S. M. and Goberdhan, D. C. I. and Wilson, C.}, title = {{Cofilin Suppresses Tau-Induced Defects in Dense-Core Granule Formation and Aβ-Induced Neurodegeneration}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.22.753479}, url = {https://doi.org/10.64898/2026.09.22.753479} } @article{alhadrami2026-c6d8e695, author = {Alhadrami, M. and Gill, E. and Perks, C. M. and Barker, R. M.}, title = {{Amyloid precursor protein: an Achilles’ heel to exploit in the treatment of prostate cancer}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.21.752657}, url = {https://doi.org/10.64898/2026.09.21.752657} } @article{ivleva2026-322c5c1f, author = {Ivleva, E. and Kriukov, E. and Arboleda-Velasquez, J. F. and Baranov, P.}, title = {{A lifespan single-cell atlas of the human developing hippocampus benchmarks familial Alzheimer’s disease brain organoids}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.18.752796}, url = {https://doi.org/10.64898/2026.09.18.752796} } @article{cording2026-f93c5f98, author = {Cording, A. and Verma, B. and Arous, A. and Rice, S. and Vine, H. and Blincowe, L. and Wainwright, S. M. and Singh, P. J. and others}, title = {{Rab11-exosome biogenesis regulators mediate Aβ-induced intercellular propagation of endolysosomal trafficking defects and neurodegeneration}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.17.752336}, url = {https://doi.org/10.64898/2026.09.17.752336} } @article{qureshi2026-118c9caa, author = {Qureshi, Y. H. and Guo, J. and Rinald, J. H. and Li, Z. and Soni, R. K. and Govindarajan, A. and Tortora, E. and Uzunova, G. and others}, title = {{Disrupting SORL1-retromer endosomal recycling in mice drives the age-dependent neurodegenerative signature of Alzheimer's disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.761980}, url = {https://doi.org/10.64898/2026.10.26.761980} } @article{stotzem2026-fb708898, author = {Stotzem, N. and Chang, S. and Cai, N. and Casale, F. P.}, title = {{Joint localization and testing reveals spatial context of differential expression}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.28.758685}, url = {https://doi.org/10.64898/2026.10.28.758685} } @article{wong2026-d98194dd, author = {Wong, K. K.}, title = {{CEP-IP with CMRF in SEA-AD Microglia: A Mitochondrial Co-expression Module Linked to Cognition}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.22.761284}, url = {https://doi.org/10.64898/2026.10.22.761284} } @article{ugur2026-bb2a526b, author = {Ugur, S. and Onal Suzek, T.}, title = {{Integrated Transcriptomic and Structural Prioritization of Sulforaphane Targets in Neurodegeneration: A Multi-Dataset In Silico Study}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.20.760417}, url = {https://doi.org/10.64898/2026.10.20.760417} } @article{panchal2026-4e5198c5, author = {Panchal, K. and Majumdar, S.}, title = {{Non-canonical proteoforms of the human fusiform gyrus in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.20.760462}, url = {https://doi.org/10.64898/2026.10.20.760462} } @article{rantanen2026-b5739013, author = {Rantanen, L. M. and Robinson, H. and Dutra Voigt, D. and Diaz, X. and Lampinen, R. and Mykkänen, S. and Kalapudas, J. and Koivisto, A. M. and others}, title = {{Alzheimer’s Disease-Associated Proteomic Changes in Olfactory Stem Cells Show Pathway-Level Transcriptomic Overlap}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.19.760270}, url = {https://doi.org/10.64898/2026.10.19.760270} } @article{venturaantunes2026-4f28fca6, author = {Ventura-Antunes, L. and Janve, V. A. and Womble, N. and Weasler, C. J. and Hai, S. A. and Brula, H. and Mobley, B. C. and Hohman, T. J. and others}, title = {{Serpin A3 is Increased in Cerebral Amyloid Angiopathy and ARIA}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.19.759840}, url = {https://doi.org/10.64898/2026.10.19.759840} } @article{you2026-647daca9, author = {You, L. and Durbin, J. L. and Meng, G. and Stallaert, W. and Li, G. and Uttam, S. and Feng, H. and Glausier, JR. and others}, title = {{Overcoming segmentation bottlenecks in brain tissue for spatial proteomic inference at population scale}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.22.761199}, url = {https://doi.org/10.64898/2026.10.22.761199} } @article{volkov2026-d5e3353a, author = {Volkov, H. and Cohen, T. and Shlayem, R. and Shapira, E. and Voinsky, I. and Klin, H. and Grad, M. and Shomron, N. and others}, title = {{RNA-sequencing of butyrate-treated human lymphoblastoid cell lines shows dysregulated genes of multiple disease-related pathways}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.21.760620}, url = {https://doi.org/10.64898/2026.10.21.760620} } @article{aslay2026-05365979, author = {Aslay, C. and Gispert, J. D. and Villoslada, P. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Tau-CTFP: A connectome-informed continuous-time first-passage model for forecasting the onset of regional tau PET abnormality}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.761855}, url = {https://doi.org/10.64898/2026.10.26.761855} } @article{loncke2026-84f8f39d, author = {Loncke, J. and Savard, M. and Picard, C. and Zetterberg, H. and Auld, D. and Badawy, M. and Ducharme, S. and {the Alzheimer’s Disease Neuroimaging Initiative} and others}, title = {{CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.24.742564}, url = {https://doi.org/10.64898/2026.08.24.742564} } @article{fischer2026-209ac9cc, author = {Fischer, L. and Vockert, N. and Höpker Fernandes, J. and Garcia-Garcia, B. and Roemer-Cassiano, S. N. and Franzmeier, N. and Gellersen, H. M. and Schumann-Werner, B. and others}, title = {{Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.18.745399}, url = {https://doi.org/10.64898/2026.08.18.745399} } @article{bimali2026-f355a22f, author = {Bimali, B. and Chen, J. and Iraji, A.}, title = {{Amyloid-Tau PET Fusion Reveals Covarying Network Territories Linked to Disease Stage, Cognition, and APOE4 in Alzheimer’s Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.11.744123}, url = {https://doi.org/10.64898/2026.08.11.744123} } @article{javid2026-9d8b8fd7, author = {Javid, S. and Nir, T. M. and Zhu, A. H. and Bhatt, R. R. and Aksman, L. M. and Jahanshad, N. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{FastEBM: Fast, Scalable, and Uncertainty-Aware Event-Based Disease Progression Modeling}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.18.739221}, url = {https://doi.org/10.64898/2026.07.18.739221} } @article{liou2026-e30b4418, author = {Liou, K. and Thomopoulos, S. I. and Villalon Reina, J. E. and Yoo, H. and Shuai, Y. and Chehrzadeh, S. and Arani, A. and Borowski, B. and others}, title = {{Comparing Harmonization Approaches for Protocol-Related Variability in Multisite Diffusion MRI Data}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.07.737018}, url = {https://doi.org/10.64898/2026.07.07.737018} } @article{liu2026-a13aaacf, author = {Liu, H. and Tong, M. and Fang, S. and Mormino, E. C. and Sperling, R. A. and Aisen, P. and Buckley, R. F. and Crane, P. K. and others}, title = {{Continuous amyloid staging complements global amyloid burden in early Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.03.756367}, url = {https://doi.org/10.64898/2026.10.03.756367} } @article{pinamonti2026-ee20452f, author = {Pinamonti, M. and Moretto, M. and Pieperhoff, L. and Arunachalam, P. and Barkhof, F. and Wink, A. M. and Lorenzini, L. and Veronese, M.}, title = {{Normative Modeling of Molecular-Enriched Functional Connectivity for Detecting Deviations from Healthy Brain Aging}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.28.754989}, url = {https://doi.org/10.64898/2026.09.28.754989} } @article{tong2026-20e069b5, author = {Tong, M. and Gao, T. and Upadhyaya, Y. and Nho, K. and Fang, S. and Saykin, A. and Yan, J. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Divergent amyloid trajectories distinguish normal aging from Alzheimer's disease progression}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.08.748727}, url = {https://doi.org/10.64898/2026.09.08.748727} } @article{mahmoudi2026-7fb049ee, author = {Mahmoudi, N. and Ghaffari, B. and Rogale, K. and Cheeseman, S. and Ritz, D. and Schmidt, A. and Han, L. and Li, Q. and others}, title = {{Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.25.740710}, url = {https://doi.org/10.64898/2026.07.25.740710} } @article{wisch2026-d4682f47, author = {Wisch, J. K. and Jiao, Z. and Millar, P. R. and McKay, N. S. and Beric, A. and Lin, W. and Baker, B. and Stauber, J. and others}, title = {{Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.08.737258}, url = {https://doi.org/10.64898/2026.07.08.737258} } @article{jafarian2026-3c12a6ad, author = {Jafarian, A. and Hughes, L. E. and Naessens, M. and Rouse, M. and Cope, T. E. and Holland, N. and Murley, A. G. and Tan Yong Wei, S. and others}, title = {{From group-level neurophysiological biomarkers to individual-level phenotyping to identify mechanisms of neurodegenerative disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.761866}, url = {https://doi.org/10.64898/2026.10.26.761866} } @article{esfahani2026-b8c364bb, author = {Esfahani, M. M. and Seraji, M. and Salem, S. and Jensen, K. M. and Fu, Z. and Adali, T. and Wang, Y. and Calhoun, V.}, title = {{NeuroMark dFNC: Transferable Dynamic-State Templates for Subject-Specific and Frequency-Resolved Chronnectomics}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.12.758630}, url = {https://doi.org/10.64898/2026.10.12.758630} } @article{huang2026-b53bd470, author = {Huang, L. and Zeng, V. and Raymond, N. and Stiltner, B. and Molho, W. and Cao, Y. and Bannai, D. and Ying, D. and others}, title = {{A large, comprehensive labeled MRI dataset of the human lateral ventricle choroid plexus}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.08.757728}, url = {https://doi.org/10.64898/2026.10.08.757728} } @article{roy2026-9b2290e4, author = {Roy, B. and Contu, V. R. and Jeziorek, M. and Friedman, W. J. and Wong, C.}, title = {{TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.21.760809}, url = {https://doi.org/10.64898/2026.10.21.760809} } @article{zelinger2026-a5e9790d, author = {Zelinger, N. and Regev, N. and Burian, E. and Kimchy, U. and Gabay, N. and Nir, Y.}, title = {{Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.12.758491}, url = {https://doi.org/10.64898/2026.10.12.758491} } @article{tan2026-39628f53, author = {Tan, G. and Demarest, P. and Kardashina, T. and Adams, J. and Willie, J. T. and Roland, J. and Gorlewicz, J. L. and Brunner, P. and others}, title = {{Vibrotactile transcutaneous auricular vagus nerve stimulation (taVNS) during working memory: convergent electrophysiological evidence for cortical efficiency}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.07.756069}, url = {https://doi.org/10.64898/2026.10.07.756069} } @article{masry2026-9fa132e6, author = {Masry, B. and Shahin, A. and Malek, Z. S.}, title = {{A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle–slow-oscillation decoupling cascade dissociates amyloid and tau}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.21.753161}, url = {https://doi.org/10.64898/2026.09.21.753161} } @article{calligaro2026-2135ac46, author = {Calligaro, H. and Khov, B. and Noel, K. and Glina, A. and van Rosmalen, L. and Ramasamy, R. and Li, Y. and Lam, M. T. Y. and others}, title = {{The circadian system is affected by Alzheimer’s disease independently from amyloid beta deposits}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.25.744599}, url = {https://doi.org/10.64898/2026.08.25.744599} } @article{morman2026-fd4e94a3, author = {Morman, C. and Agarwal, T. and Ortigosa-Pascual, L. and Knowles, T. P. and Abelein, A.}, title = {{Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.27.762205}, url = {https://doi.org/10.64898/2026.10.27.762205} } @article{vandenheuvel2026-b5f4b141, author = {van den Heuvel, L. and Stähli, D. A. and Radecke, J. and Daraspe, J. and Shafiei, N. and Lewis, A. J. and van de Berg, W. D. J. and Genoud, C. and others}, title = {{Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human Brain}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.04.749518}, url = {https://doi.org/10.64898/2026.09.04.749518} } @article{algamal2026-005bc584, author = {Algamal, M. and Yokomizo, S. and Ndambakuwa, W. and Abdallah, S. and Sanchez-Mico, M. V. and Gillani, R. and da Silva, P. and Rajput, A. and others}, title = {{Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.07.749938}, url = {https://doi.org/10.64898/2026.09.07.749938} } @article{unaran2026-73b99cce, author = {Unaran, E. and Adebiyi, O. and Krishnan, M. R. and Bussey, T. J. and Saksida, L. M. and Prado, M. A. and Prado, V. F. and Menon, R. S.}, title = {{Myelin maturation failure and oligodendrocyte precursor loss underlie default mode network disruption in a humanized APP knock-in model of Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.12.744193}, url = {https://doi.org/10.64898/2026.08.12.744193} } @article{pallerla2026-922ec944, author = {Pallerla, A. V. and Lucido, C. C. and Saito, K. and Nolt, G. L. and Arbones-Mainar, J. M. and Funnell, J. L. and Satish, D. and Smith, L. M. and others}, title = {{Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.06.26.734793}, url = {https://doi.org/10.64898/2026.06.26.734793} } @article{pikus2026-5846ffcd, author = {Pikus, P. and Healey, G. S. and Xia, E. and Shautidze, G. and Siddapureddy, N. and Lee, Y. and Albanese, C. and Rodriguez, O. and others}, title = {{Intravenous anti-Aβ immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.02.09.704876}, url = {https://doi.org/10.64898/2026.02.09.704876} } @article{aggarwal2026-715fc47c, author = {Aggarwal, G. and Banerjee, S. and Bhadra, A. K. and Hwang, J. J. and Malabana, D. A. O. and Nagarajan, N. and Smith, D. M. and Kollarapu, J. and others}, title = {{Progranulin deficiency promotes neuroinflammation through cathepsin B-mediated activation of the NLRP3 inflammasome}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.11.758389}, url = {https://doi.org/10.64898/2026.10.11.758389} } @article{fuchs2026-87ec3a14, author = {Fuchs, U. and Schröder, S. and Pena, T. and Krüger, D. M. and Burkhardt, S. and Schütz, A. and Hempel, N. and Gisa, V. and others}, title = {{Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.03.736275}, url = {https://doi.org/10.64898/2026.07.03.736275} } @article{jiang2026-5ac0488b, author = {Jiang, T. and Xu, X. and Yu, Y. and Zhu, C. and Ma, C. and Tang, Y. and Min, L. and Tan, M. and others}, title = {{HnRNPAB -targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimer’s disease-associated alternative splicing}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.02.736008}, url = {https://doi.org/10.64898/2026.07.02.736008} } @article{biju2026-e14002dc, author = {Biju, A. P. and Karim, F. and Schafer, D. M. and Sison, S. A. and Liang, C. and Head, E. and Mukherjee, J.}, title = {{Measurement of tau protein and Aβ amyloid plaques in postmortem human brains of Down syndrome and Alzheimer’s disease by using [ 125 I]IPPI and [ 125 I]IBETA autoradiography}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.01.17.700075}, url = {https://doi.org/10.64898/2026.01.17.700075} } @article{zamoraloyarte2025-1f2cbfa0, author = {Zamora-Loyarte, D. I. and León-Arcia, K. and Pérez-Leal, G. and Quintero-Alvarez, H. and López-Armenteros, M. and Sánchez-Quesada, A. and Nordelo-Ávila, N. and Vázquez-Mojena, Y.}, title = {{Generation of a recombinant GST-Tau antigen for indirect ELISA in evaluating Alzheimer’s disease vaccines}}, journal = {bioRxiv}, year = {2025}, doi = {10.1101/2025.09.18.676867}, url = {https://doi.org/10.1101/2025.09.18.676867} } @article{jiang2025-2657e87d, author = {Jiang, Y. and Tetlow, A. M. and Lin, Y. and Ji, C. and Laborc, K. F. and Mar, A. C. and Pan, R. and Kong, X. and others}, title = {{Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies}}, journal = {bioRxiv}, year = {2025}, doi = {10.1101/2025.06.30.662446}, url = {https://doi.org/10.1101/2025.06.30.662446} } @article{palmer2026-2d6dd70a, author = {Palmer, Z. and Koirala, S. and Talukdar, N. and Zhang, X. and Garver, H. and Mahlmeister, M. and Huang, L. and Joseph, D. and others}, title = {{In Vivo Transcriptomics-Based Framework for Systematic Indication Expansion}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.12.758524}, url = {https://doi.org/10.64898/2026.10.12.758524} } @article{wohlfeld2026-d54ff148, author = {Wohlfeld, C. and Blas, A. and Woodruff, J. and Frick, M. and Maciejewska, N. and Patel, A. and Grillo, C. and Reagan, L. and others}, title = {{Semaglutide Activates the Orexin/Hypocretin and Basal Forebrain Cholinergic Systems and Increases Acetylcholine Levels in the Hippocampus of Young and Aged Rats}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.03.742612}, url = {https://doi.org/10.64898/2026.08.03.742612} } @article{rausch2026-a2d21860, author = {Rausch, D. M. and Ludwig, M. Q. and Bentsen, M. A. and Hansen, S. N. and Secher, A. and Holst, D. and Moreno, J. and Das, V. and others}, title = {{Semaglutide Attenuates Neuroinflammation in Mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.01.10.698763}, url = {https://doi.org/10.64898/2026.01.10.698763} } @article{holtz2026-d33b0eda, author = {Holtz, M. and de Haan, S. and Castellví Domingo, C. and Madsen, N. G. and Salazar, M. D. F. and Hansson, F. G. and van Aalst, A. C. A. and Arnesen, J. A. and others}, title = {{Biocatalytic Production of Galantamine in Yeast through Cytochrome P450 Optimization}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.09.750345}, url = {https://doi.org/10.64898/2026.09.09.750345} } @article{yadav2026-d0da0ad5, author = {Yadav, D. K. and Connor, C. W. and Gabel, C. V.}, title = {{Early Amyloid-β Toxicity Disrupts Nervous System Connectivity During Aging in Caenorhabditis elegans}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.27.740981}, url = {https://doi.org/10.64898/2026.07.27.740981} } @article{abdelsalam2026-dfc076bf, author = {Abdelsalam, N. A. and Elsadany, M. and Badr, E.}, title = {{Common Dysregulated Pathways and Genes in Alzheimer’s, Parkinson’s, and Huntington’s Diseases: A Computational Analysis to Nominate Candidate Gene Targets for Drug Repurposing}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.22.739294}, url = {https://doi.org/10.64898/2026.07.22.739294} } @article{c2026-e330dfe2, author = {Ç, Özkurt}, title = {{Single-cell gene networks nominate IKZF1 as an Alzheimer’s microglial regulator}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.14.738463}, url = {https://doi.org/10.64898/2026.07.14.738463} } @article{matsumoto2026-cd287502, author = {Matsumoto, N. and Choi, H. and Freda, P. J. and Hernandez, M. E. and Wang, Z. P. and Moore, J. H.}, title = {{EcoXAI: Autonomous Agentic Ecosystem for Explainable Artificial Intelligence and Biomedical Discovery}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.08.737358}, url = {https://doi.org/10.64898/2026.07.08.737358} } @article{zheng2026-65c03da7, author = {Zheng, C. and Zhai, T. and Zhang, F. and Shen, L.}, title = {{Integrative single-nucleus multi-omics profiling identifies candidate regulators and signaling axes in Alzheimer’s disease lipid-processing microglia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.10.737805}, url = {https://doi.org/10.64898/2026.07.10.737805} } @article{onawole2026-45a812c1, author = {Onawole, A. T. and Adegoke, R. A. and Amoo, O.}, title = {{TrustPGS: When can a polygenic score be trusted? A per-individual reliability framework across ancestries}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.01.735762}, url = {https://doi.org/10.64898/2026.07.01.735762} } @article{lifshitz2026-52e9bd33, author = {Lifshitz, J. and Ruhland, A. and Bisesi, J. and Karamanova, N. and Law, L. M. and Griffiths, D. R. and Fuentes, A. and Bergamino, M. and others}, title = {{Subacute and Chronic Cognitive and Cerebrovascular Functional Consequences of Mild Traumatic Brain Injury in Rats}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.22.740068}, url = {https://doi.org/10.64898/2026.07.22.740068} } @article{shin2026-5dc5d3f9, author = {Shin, J. and Yoo, J. and Cho, Y. and Gupta, A. and Mao, P. H. and Thakkar, K. and Eddy, T. A. and Jung, K. J. and others}, title = {{Circular Data Analysis for Spatial Omics}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.29.755467}, url = {https://doi.org/10.64898/2026.09.29.755467} } @article{arai2026-fb45f8a8, author = {Arai, M. and Yue, J. and Shams, E. and Stevens, C. J. and Han, H. and Gibson, R. and Yildirim, T. and Feldman, H. H. and others}, title = {{Chronic trazodone treatment consolidates sleep, improves memory, and reduces amyloid pathology in a mouse model of Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.20.746036}, url = {https://doi.org/10.64898/2026.08.20.746036} } @article{carriquiriborde2026-c605517a, author = {Carriquiriborde, V. and Yue, J. and Cheng, W. H. and Yildirim, T. and Fan, J. and Tok, S. and Kelly, M. and Wellington, C. L. and others}, title = {{Repeated mild traumatic brain injury does not affect sleep or epileptiform activity one-month post-injury in a knock-in mouse model of Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.24.740449}, url = {https://doi.org/10.64898/2026.07.24.740449} } @article{copeland2026-408c21ca, author = {Copeland, M. H. and Youngstrom, D. E. and Konrad, K. S. and Diering, G. H. and Letsinger, A. C. and Aksu, L. R. and Yakel, J. L. and Cushman, J. D.}, title = {{Diphenhydramine Disrupts Sleep Architecture in 5XFAD Alzheimer’s Disease Model and Wild-Type Mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.22.739929}, url = {https://doi.org/10.64898/2026.07.22.739929} } @article{sanmartin2026-3cd18b34, author = {San-Martín, S. and Aedo, C. and Vidal, V. and Leiva, A. and Delgado, C. and Délano, P. H. and Medel, V.}, title = {{Auditory brainstem response latencies, but not amplitudes, are associated with gray matter volumes across the human auditory pathway in older adults}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.21.746342}, url = {https://doi.org/10.64898/2026.08.21.746342} } @article{pan2026-1aad7f20, author = {Pan, Z. and Połeć, M. and Avgerinos, A. and Bi, K. and Green, T. and Cardin, V.}, title = {{Crossmodal plasticity effects of hearing loss and ageing in the human auditory cortex}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.06.08.730968}, url = {https://doi.org/10.64898/2026.06.08.730968} } @article{fuentessantamaria2026-b3cc5f32, author = {Fuentes-Santamaría, V. and Alvarado, J. C. and Benitez, Z. and Gabaldón-Ull, M. C. and Saido, T. C. and Saito, T. and Lenarz, T. and Juiz, J. M.}, title = {{Alzheimer disease β-amyloid pathology accelerates age-related hearing loss: evidence from App NL-F “knock-in” mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.05.25.727095}, url = {https://doi.org/10.64898/2026.05.25.727095} } @article{abraham2026-f6e523dc, author = {Abraham, I. and Ajmera, S. and Zhang, W. and Leaver, A. M. and Sutton, B. P. and Peelle, J. E. and Husain, F. T.}, title = {{Multi-site MRI analysis of morphometric differences in brain regions in the presence of hearing loss and tinnitus across the adult lifespan}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.03.06.710136}, url = {https://doi.org/10.64898/2026.03.06.710136} } @article{kulkarni2026-155df2b8, author = {Kulkarni, S. and Conner, A. and Rausis, O. and Pitchford, D. and Wang, Z. and Batchu, A. and Liberman, L. and Liberman, M. C. and others}, title = {{Physiological, Histological, and Cognitive Characterization of a Rhesus Macaque Model of Presbycusis}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.03.24.714040}, url = {https://doi.org/10.64898/2026.03.24.714040} } @article{merour2026-4bfc6db9, author = {Merour, E. and Ghatage, T. and Corbett, C. and DeBerge, M. and Kunjamma, R. and Steckler, I. and Heidari, M. and Sorond, F. A. and others}, title = {{Oligodendrocyte stress response as a driver of vascular dementia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.12.758545}, url = {https://doi.org/10.64898/2026.10.12.758545} } @article{pfabe2026-5da1af17, author = {Pfabe, J. and Postic, S. and Miglinci, L. and Krnjic, A. and Ahmed, H. and Eisenberg, T. and Tadic, J. and Raval, K. and others}, title = {{PFKFB3 inhibition restores β-cell responsiveness to acetylcholine in a 3xTg-AD pancreatic tissue-slice model}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.30.755766}, url = {https://doi.org/10.64898/2026.09.30.755766} } @article{goyal2026-f0e1911c, author = {Goyal, G. and Palanisamy, P. and Paul, A. and Paul, S.}, title = {{DNA polymerase kappa supports repair-associated DNA synthesis and neuronal genome resilience}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.01.756094}, url = {https://doi.org/10.64898/2026.10.01.756094} } @article{pandey2026-72021b1f, author = {Pandey, R. and Olabi, T. and Lee, M. and Urbanc, B.}, title = {{Distinct Aβ40 and Aβ42 co-assembly pathways with free lipids: Experiment-driven MD study}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.28.755027}, url = {https://doi.org/10.64898/2026.09.28.755027} } @article{lee2026-f718b1d2, author = {Lee, S. and Ha, J. and Garimella, A. H. and Baratono, SR. and Burt, G. T. and Karim, H. T. and Andreescu, C. and Sperling, R. and others}, title = {{Network Localization of Anxiety as an Early Manifestation of Alzheimer’s Disease-related Neurodegeneration}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.24.761536}, url = {https://doi.org/10.64898/2026.10.24.761536} } @article{petrican2026-a4b6031c, author = {Petrican, R. and Fornito, A.}, title = {{Alignment with sex-typical brain architecture: Links to mood pathology, sex hormones and transcriptomics of neurodegenerative conditions}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.27.754773}, url = {https://doi.org/10.64898/2026.09.27.754773} } @article{murthygowda2026-8155c39b, author = {MurthyGowda, S. and Huyghue, K. and Castillo, B. and Gugala, F. and Li, W. and Dubnau, J.}, title = {{Early life social isolation primes flies for more rapid TDP-43 dependent neurodegeneration later in life}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.23.753732}, url = {https://doi.org/10.64898/2026.09.23.753732} } @article{kowash2026-ca79f1b2, author = {Kowash, Z. and Lim, J. and Annalora, A. J. and Wang, H. and Cui, J. Y.}, title = {{Triple-Omics Analysis Unveiled the Neuroprotective Mechanisms of Akkermansia muciniphila in an Environmental Exposure-Linked Mouse Model of Alzheimer’s Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.30.755812}, url = {https://doi.org/10.64898/2026.09.30.755812} } @article{fragola2026-76961fd3, author = {Fragola, G. and Weeks, R. D. and Wolter, J. and Bryan, A. F. and Kapfer, K. N. and Tian, X. and Necarsulmer, J. C. and Evangelista, B. A. and others}, title = {{High-Content Screening Identifies Dithiocarbamates As A Class Of Chemicals That Disrupts TDP-43 Proteostasis}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.14.741835}, url = {https://doi.org/10.64898/2026.08.14.741835} } @article{yan2026-93e00b0f, author = {Yan, H. and Bhat, Y. and Malahov, P. and Sabogal-Guáqueta, A. M. and Mitchell-Garcia, T. and Chen, T. and Genestant, E. and Iveša, M. and others}, title = {{Diesel exhaust particles disrupt mouse and human iPSC-derived microglial function and Amyloid-β clearance in Alzheimer’s disease models}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.20.739493}, url = {https://doi.org/10.64898/2026.07.20.739493} } @article{shkirkova2026-cb9eb788, author = {Shkirkova, K. and Maria, N. S. S. and Anson, H. and Aghaei, Y. and Badami, M. M. and Chakhoyan, A. and Godoy-Lugo, J. A. and Chung, C. and others}, title = {{Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer’s disease by chemically distinct air pollutants}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.01.06.696601}, url = {https://doi.org/10.64898/2026.01.06.696601} } @article{dasgupta2026-cfdd9ac7, author = {Dasgupta, M. and Konar, A. and Nagar, A.}, title = {{Magnetic Field–Enhanced Docosahexaenoic Acid Delivery for Acetylcholine Restoration in Alzheimer’s Disease: an In Silico Study}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.28.755051}, url = {https://doi.org/10.64898/2026.09.28.755051} } @article{kani2026-65d6a8d2, author = {Kani, R. and Kaku, T. and Arai, Y. and Etani, T. and Huh, S. and Saito, K. and Homma, S. and Takahashi, K. and others}, title = {{Postmortem Alterations of Metabotropic Glutamate Receptors across Neuropsychiatric Disorders: A Systematic Review}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.29.748003}, url = {https://doi.org/10.64898/2026.08.29.748003} } @article{zhan2026-540a14ba, author = {Zhan, J. and Yang, C. and Nellis, M. and Tan, Y. and Smith, M. R. and Alvarez, J. and Liang, D. and Dunlop, A. and others}, title = {{Development of a metabolomics-based index to monitor dietary effects on chronic inflammation: The Dietary Metabolomics Inflammation Index}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.06.736618}, url = {https://doi.org/10.64898/2026.07.06.736618} } @article{badachhape2026-78820a75, author = {Badachhape, A. A. and Bhandari, P. and Khan, R. and Bhavane, R. and Menon, R. and Parekh, P. and Admane, P. and Ngan, E. and others}, title = {{Molecular MRI of Neuroinflammation in Alzheimer's Disease using a Folate-targeted Nanoprobe}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.27.761963}, url = {https://doi.org/10.64898/2026.10.27.761963} } @article{devlin2026-50f6f595, author = {Devlin, M. and Rodstrom, K. and Benkerdagh, C. and Ber, S. and Ramsden, N. and Rowlett, M. and Cordeiro, S. and Hayre, M. and others}, title = {{A Binding Site for CVN293 Reveals a Mechanism for Allosteric Control of THIK-1 K2P Channel Gating}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.27.761881}, url = {https://doi.org/10.64898/2026.10.27.761881} } @article{quang2026-09848cb6, author = {Quang, D. and Summers, R. and Dooling, B. R. and Esquer, H. and Zhou, Q. and LaBarbera, D. V. and Vergara, M. N. and Chial, H. J. and others}, title = {{High-content imaging of live microglia-containing Alzheimer’s disease brain organoids}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.761970}, url = {https://doi.org/10.64898/2026.10.26.761970} } @article{bass2026-2a77547e, author = {Bass, R. and Masterson, H. V. and Chen, Y. and Xu, B.}, title = {{Astrocytic ablation of truncated TrkB receptors reduces amyloid plaques and prevents synaptic loss in 5xFAD mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.20.760443}, url = {https://doi.org/10.64898/2026.10.20.760443} } @article{elahi2026-5cb25560, author = {Elahi, M. and Burd, I. and Yang, P. and Shen, W.}, title = {{Early Insulin Signaling Abnormalities and Oxidative Stress Responses in PS19 Tau Transgenic Mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.16.759692}, url = {https://doi.org/10.64898/2026.10.16.759692} } @article{dinakarapandian2026-cf0b65f1, author = {Dinakarapandian, D. M. and Rao Sudarshan, T. and Griffin, M. N. and Ramaswamy, P. and Nguyen, P. H. and Chiu, T. and Li, C. and Kamalaldinezabadi, S. S. and others}, title = {{Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.14.759149}, url = {https://doi.org/10.64898/2026.10.14.759149} } @article{tu2026-39d431f5, author = {Tu, A. and Liu, S.}, title = {{Function-oriented microglial transcriptional scores in Alzheimer’s disease: resolving terminal functions beyond activation states}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.14.759278}, url = {https://doi.org/10.64898/2026.10.14.759278} } @article{ghosh2026-549141c1, author = {Ghosh, B. and Wang, S. and Qi, C. and Ghosh, A. and Comerota, M. and Rajpurohit, C. S. and Zeldin, D. C. and Zheng, H.}, title = {{Astrocytic sEH–EET signaling regulates microglial lysosomal function and suppresses the STING–Type I interferon pathway in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.16.759679}, url = {https://doi.org/10.64898/2026.10.16.759679} } @article{ayan2026-b4d44c1a, author = {Ayan, E. and Palermo, F. and Cavioli, G. and Bostan, S. and Dogan, B. Z. and Kilic, K. and Kaplan, A. A. and Bukreeva, I. and others}, title = {{Insulin fails to mitigate amyloid pathology but modulates intestinal morphology in the 5xFAD model revealed by synchrotron-based XPCT}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.10.758244}, url = {https://doi.org/10.64898/2026.10.10.758244} } @article{suh2026-026f9a99, author = {Suh, Y. and Wang, H. and Li, L. and Gu, H. and Johnson-Martinez, J. and Magis, A. T. and Gibbons, S. M. and Cui, J. Y.}, title = {{The microbial soy metabolite S-equol mitigates cadmium neurotoxicity in mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.01.756095}, url = {https://doi.org/10.64898/2026.10.01.756095} } @article{xu2026-ac98f5b7, author = {Xu, Z. and Chen, J. and Yu, J. and Duan, J. and Xie, Y. and Gong, Y. and Wang, P. and Lei, X. and others}, title = {{Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer’s Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.01.748473}, url = {https://doi.org/10.64898/2026.09.01.748473} } @article{huang2026-e93b8a8b, author = {Huang, Z. and McGrath, P. M. and Ferdinand, D. C. and McCormick, B. A. and Ward, D. V. and Bucci, V. and Haran, J. P.}, title = {{Gut community-level analysis reveals an altered balance between Phocaeicola vulgatus and Bacteroides fragilis in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.12.743985}, url = {https://doi.org/10.64898/2026.08.12.743985} } @article{ruizuribe2026-e2da99b8, author = {Ruiz-Uribe, N. E. and Alfadhel, M. and Wolf, N. and Murray, S. E. and Gross, E. and Devine, A. and Shaby, D. G. and Belali, S. and others}, title = {{Depth-Dependent Alterations in Cerebral Blood and Tissue Oxygenation Associated with Tau in Alzheimer’s Disease Models}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.09.757981}, url = {https://doi.org/10.64898/2026.10.09.757981} } @article{elia2026-32eba34d, author = {Elia, A. and Vazquez-Torres, R. and Carey, A. and Wolf, M. and Gade, V. R. and Alves, M. and Fossati, S.}, title = {{Carbonic anhydrase inhibition rescues heart function in the Tg2576 Alzheimer’s mouse model by ameliorating cardiac amyloid-β pathology and neurotrophic-signaling impairment}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.08.757731}, url = {https://doi.org/10.64898/2026.10.08.757731} } @article{zhu2026-08a4bdbf, author = {Zhu, Y. and Yang, D. and Chen, J. and Wang, Q. and Xiong, W. and Wang, J. and Chen, H. and Verkhratsky, A. and others}, title = {{Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood–brain barrier disruption in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.30.755839}, url = {https://doi.org/10.64898/2026.09.30.755839} } @article{napolitano2026-0d65979f, author = {Napolitano, E. and Marino, C. and Grimaldi, M. and Buonocore, M. and Santoro, A. and Barbato, G. and D’Ursi, A. M.}, title = {{The protective effect of NGF mutant CHF6467 in SH SY5Y cells exposed to Aβ(1–42): a pharmacometabolomic approach}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.06.753538}, url = {https://doi.org/10.64898/2026.10.06.753538} } @article{saadi2026-e9af705a, author = {Saadi, F. and Cho, Y. and Katritch, IV. and Lugo, B. and Wu, Y. and Smyth, L. C. and Bosch, M. and Telfer, K. A. and others}, title = {{APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.02.756327}, url = {https://doi.org/10.64898/2026.10.02.756327} } @article{onken2026-b6aeedca, author = {Onken, M. D. and Cooper, J. A.}, title = {{The Alzheimer’s Disease-associated gene CD2AP regulates permeability of endothelial cells and transendothelial migration of immune cells}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.01.755982}, url = {https://doi.org/10.64898/2026.10.01.755982} } @article{nortley2026-211812a0, author = {Nortley, R. and Anderle, S. and Sideris-Lampretsas, G. and Davis, H. and Sethi, H. and Alasaadi, D. N. and Acton, S. and Attwell, D.}, title = {{Neurodegeneration-inducing macromolecules exit the brain via nanovascular conduits formed by reticular fibroblasts}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.21.752863}, url = {https://doi.org/10.64898/2026.09.21.752863} } @article{bhatt2026-94d50e55, author = {Bhatt, N. N. and Tabrizi, Z. and Janulis, J. and Chakraborty, S. and Weick, M. and Franciosa, S. A. and Rodriguez Moore, G. and Agatemor, C. and others}, title = {{Reducing Neutrophil Sialic Acid Residues Alleviates Cerebral Hypoperfusion in Alzheimer’s Models}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.23.753660}, url = {https://doi.org/10.64898/2026.09.23.753660} } @article{riordan2026-da5e172b, author = {Riordan, R. and Saxton, A. and Han, M. and Parrot, K. and Kraemer, B.}, title = {{TMEM106B C-Terminal fragment aggregation exacerbates α-synuclein and TDP-43 proteinopathy phenotypes}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.29.762961}, url = {https://doi.org/10.64898/2026.10.29.762961} } @article{mohanty2026-916cd2ae, author = {Mohanty, S. and Bosworth, S. and Ramaswamy, K. and Natarajan, C. and Krishnan, B.}, title = {{Repeated VU0155069 Treatment Is Associated with Region- and Pathological Stage-Specific Dendritic Spine Remodeling in Female 3xTg-AD Mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.762038}, url = {https://doi.org/10.64898/2026.10.26.762038} } @article{vilkaite2026-1d27cabc, author = {Vilkaite, G. and Volcov, E. and An, L. and Xiao, Y. and Hristovska, I. and Rosat Consiglio, C. and Pichet-Binette, A. and Mattsson-Carlgren, N. and others}, title = {{A coordinated and reproducible multicellular response to AD pathology}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.19.759610}, url = {https://doi.org/10.64898/2026.10.19.759610} } @article{serratto2026-39562558, author = {Serratto, G. M. and Barriga, G. G. and Rosebrock, D. and Simon, M. and Kuhn, R. and von der Kammer, H. and Gruber-Schoffnegger, D.}, title = {{A brain immune phenotype independent of Alzheimer’s Disease associates with amyloid susceptibility and systemic inflammation}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.21.760450}, url = {https://doi.org/10.64898/2026.10.21.760450} } @article{maita2026-e1e796ab, author = {Maita, N. and Kim, S. and Kajino, Y. and Kato, M.}, title = {{ALS-associated mutations reveal a conserved C-terminal self-assembly module in the TDP-43 low-complexity domain}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.09.756561}, url = {https://doi.org/10.64898/2026.10.09.756561} } @article{bagade2026-5a084b25, author = {Bagade, A. V. and Miller, R. and Dearborn, J. T. and Basore, K. and Summers, B. and Readnour, B. and Koelling, M. and O’Shea, J. and others}, title = {{Intrastriatal injection of amplified Lewy body dementia (LBD) fibrils in mice results in accumulation of fibrils with LBD structure and neurodegeneration}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.06.757103}, url = {https://doi.org/10.64898/2026.10.06.757103} } @article{thakur2026-ca6358d7, author = {Thakur, K. and Péladeau, C. and Hewitt, M. and Baumann, K. and Cai, D. and Woulfe, J. M. and Tomlinson, J. J. and Schlossmacher, M. G. and others}, title = {{ASC specks and α-synuclein amplify microglial NLRP3 inflammasome activation and co-localize with Lewy body pathology}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.02.756339}, url = {https://doi.org/10.64898/2026.10.02.756339} } @article{sun2026-f4157059, author = {Sun, M. N. and Vaughey, K. and Liu, B. and Guo, H. and Huganir, R. and Morris, M.}, title = {{Neuronal Hyperactivity Induces Tau Phosphorylation Selectively in Excitatory Pyramidal Neurons Which Contributes to GluA2 Regulation}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.762028}, url = {https://doi.org/10.64898/2026.10.26.762028} } @article{sell2026-5ecfa0d2, author = {Sell, J. and Loi, E. A. and Rahmati, V. and Majoros, M. and Kirmann, T. and Haselmann, H. and Stumpf, A. and Götz, T. and others}, title = {{Anti-GABA B receptor autoimmunity causes cognitive decline by presynaptic pathology}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.22.761036}, url = {https://doi.org/10.64898/2026.10.22.761036} } @article{wigerius2026-1229dd42, author = {Wigerius, M. and Labana, P. K. and Diab, A. and Krueger, S. and Fawcett, J. P.}, title = {{LATS2 modulates synaptic organization and function by regulating actin dynamics}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.16.758881}, url = {https://doi.org/10.64898/2026.10.16.758881} } @article{heuer2026-8adbb044, author = {Heuer, S. E. and Ahsan, F. M. and Terzioglu, G. and Misra, A. and Duong, D. and Katkar, C. and Giera, M. and van der Kant, R. and others}, title = {{The Alzheimer’s disease risk gene ABCA7 regulates microglial lysosomal and lipid homeostasis and promotes phagocytosis to maintain neuronal health}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.16.759681}, url = {https://doi.org/10.64898/2026.10.16.759681} } @article{rajic2026-c51e2b7b, author = {Rajic, A. J. and Ojeda-Juarez, D. and Sarkar, D. and Sumowski, P. and Flores, S. and Pourhamzeh, M. and Soldau, K. and Pizzo, D. P. and others}, title = {{Reduced phosphatases and hyperphosphorylated glutamatergic receptors persist from early to late stages of prion disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.14.751571}, url = {https://doi.org/10.64898/2026.10.14.751571} } @article{georgiades2026-22f78c0d, author = {Georgiades, T. and Griffiths, J. and Gibbs, F. and Chandra, E. and Papageorgopoulou, M. and Liang, D. and Whitwell, H. J. and Matthews, P. M. and others}, title = {{Stage-specific proteomic signatures of synaptopathy in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.02.755976}, url = {https://doi.org/10.64898/2026.10.02.755976} } @article{meena2026-5c2dbb27, author = {Meena, R. K. and Duddu, A. S. and Jolly, M. K. and Prasad, H.}, title = {{Endosomal pH Triggers Amyloid β Oligomerization and Maladaptive Phenotypic Plasticity in Alzheimers Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.23.752284}, url = {https://doi.org/10.64898/2026.09.23.752284} } @article{shi2026-27bcc85b, author = {Shi, J.}, title = {{LSD-pipeline: Causal Inference of miRNA Network Effects in Alzheimer's Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.17.747423}, url = {https://doi.org/10.64898/2026.09.17.747423} } @article{aceituno2026-d385a25d, author = {Aceituno, K. and Granger, K. and Leon, J. and Godoy-Lugo, J. A. and Young, K. E. and Joseph, T. and Liu, K. and Kruijff, I. and others}, title = {{Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.16.752181}, url = {https://doi.org/10.64898/2026.09.16.752181} } @article{suissa2026-2f103e54, author = {Suissa, M. V. and Koutures, A. and Harker, S. and Vaughan, B. and Kfir, J. and Bhat, A. and Shihabi, R. and Dewal, M. B. and others}, title = {{Autonomous AI-Driven Nanoscale Spatial Mapping Reveals Novel Targets and Ternary Architectures in 5xFAD Alzheimer's Disease Model}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.09.750448}, url = {https://doi.org/10.64898/2026.09.09.750448} } @article{patil2026-039d6010, author = {Patil, S. P. and Kuehn, B. and Schlosser, R. and Samohod, J.}, title = {{Discovery of Bavachin as a Dual Trk-A/Trk-B Agonist via Integrated Computational Screening and Experimental Validation}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.10.750759}, url = {https://doi.org/10.64898/2026.09.10.750759} } @article{gronlie2026-816ff7e2, author = {Grønlie, M. B. and Mikalsen Kollstrøm, A. and Sandvig, A. and Sandvig, I.}, title = {{Ion modulation restores local synaptic function in APOE4 neuronal networks despite persistent impairments in global network organization}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.08.750089}, url = {https://doi.org/10.64898/2026.09.08.750089} } @article{makhlouf2026-4949dd36, author = {Makhlouf, H. and Dorigatti, A. O. and Hernandez, S. and de Rosa, N. and Miller, L. and Hussong, S. and Holstein, D. and Lechleiter, J. and others}, title = {{Soluble pathogenic tau transmission to astrocytes drives cellular senescence and neurovascular uncoupling in a model of Alzheimer’s tauopathy}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.08.750215}, url = {https://doi.org/10.64898/2026.09.08.750215} } @article{li2026-7bf20a60, author = {Li, Y. and ploumi, C. and Volbracht, C. and Tian, W. and Kalogeraki, N. and Kitopoulou, K. and Navarro, C. C. and Li, Z. and others}, title = {{BNIP3L/NIX-mediated mitophagy limits Alzheimer’s disease pathology and preserves neuronal function}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.18.759942}, url = {https://doi.org/10.64898/2026.10.18.759942} } @article{kong2026-36e22c46, author = {Kong, Y. and Zhai, T. and Zhao, H.}, title = {{Spatiotemporal transcriptomic dynamic across the auditory pathway from young to old age in 5xFAD Alzheimer disease mice}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.17.759861}, url = {https://doi.org/10.64898/2026.10.17.759861} } @article{navarro2026-b65d2812, author = {Navarro, M. and Aquino, J. and Shi, K. and Lin, H. and Monfared, V. and Garcia, J. C. and Seylani, A. and Komędera, M. and others}, title = {{Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.16.759726}, url = {https://doi.org/10.64898/2026.10.16.759726} } @article{roy2026-2cee5949, author = {Roy, B. and Roy, P. K.}, title = {{Subtype-Selective Neuronal Vulnerability and Compensatory Neuroglial Remodeling in Human Cortical Dementia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.03.756274}, url = {https://doi.org/10.64898/2026.10.03.756274} } @article{yarlagadda2026-02a60d50, author = {Yarlagadda, B. and Kumar, V.}, title = {{Genetically distinct neurodegenerative proteinopathies engage overlapping proteostasis components}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.28.753000}, url = {https://doi.org/10.64898/2026.09.28.753000} } @article{grant2026-2682dc91, author = {Grant, R. A. and Park, L. H. E. and Wahl, D. and LaRocca, T. J.}, title = {{Apigenin Improves Healthspan and Protects Against Alzheimer’s Disease-Associated Proteotoxicity in C. elegans}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.23.753917}, url = {https://doi.org/10.64898/2026.09.23.753917} } @article{poynter2026-fce6816e, author = {Poynter, C. L. and Sánchez-Carbonell, M. and Kendall, R. L. and Garcia, M. A. and Machado de Melo, D. and McPeck, R. N. and Mirita, C. and Brown, J. M. and others}, title = {{Micro- and nanoplastics alter electrophysiological brain patterns and reshape human neurodevelopmental trajectories}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.18.752710}, url = {https://doi.org/10.64898/2026.09.18.752710} } @article{gergian2026-bd7ce9bb, author = {Gergian, C. and Urbanaviciute, P. and Wells, P. M. and Transfeld, J. L. and Askarova, A. and Yaa, R. M. and Wu, Y. and Ziegler, K. C. and others}, title = {{Cell type-specific histone acetylation landscape in Alzheimer’s disease reveals a putative role of MITF in microglia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.09.750356}, url = {https://doi.org/10.64898/2026.09.09.750356} } @article{kelberman2026-122cfbbc, author = {Kelberman, M. A. and Winther, K. E. and Ibrahiem, R. E. and Albregts, E. G. and Pardasani, M. and Watanabe, Y. L. and Donaldson, Z. R.}, title = {{Hypothalamic tau P301L pathology disrupts pair bonding in monogamous prairie voles}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.28.755178}, url = {https://doi.org/10.64898/2026.09.28.755178} } @article{raposopereira2026-c6276936, author = {Raposo Pereira, F. and Chaumon, M. and Dubois, B. and Bakardjian, H. and Andrade, K. and Habert, M. and Younsi, N. and La Corte, V. and others}, title = {{Episodic memory ERPs reflect preclinical Alzheimer’s disease progression}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.11.737503}, url = {https://doi.org/10.64898/2026.07.11.737503} } @article{pan2026-47a5412b, author = {Pan, A. and Zhai, T. and Lee, J. and Zheng, C. and Kim, D. and Shen, L.}, title = {{Integrating Multisource Target Evidence with Machine-Learning Potency Prediction for Alzheimer’s Disease Drug Discovery}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.14.759026}, url = {https://doi.org/10.64898/2026.10.14.759026} } @article{chattopadhyay2026-90e2d34e, author = {Chattopadhyay, T. and Shelar, K. and Thomopoulos, S. I. and Thompson, P. M.}, title = {{Understanding Performance Plateaus and Representation Collapse in 3D MRI Transformers Trained to Classify Brain Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.15.759510}, url = {https://doi.org/10.64898/2026.10.15.759510} } @article{radwan2026-cccc408d, author = {Radwan, M. and Lind, P. G. and Yazidi, A.}, title = {{EEG Pathology Detection via Clinical Concept Bottleneck Models}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.04.756607}, url = {https://doi.org/10.64898/2026.10.04.756607} } @article{hillman2026-35cc200a, author = {Hillman, N. and Chen, A. A. and Hu, F. and Vandekar, S. N. and Melhem, R. and Beason-Held, L. L. and Satterthwaite, T. D. and Davatzikos, C. and others}, title = {{Imputation-Based Harmonization Mitigates Site Effects Without Data Leakage in Machine Learning Studies}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.28.755204}, url = {https://doi.org/10.64898/2026.09.28.755204} } @article{smith2026-132c6603, author = {Smith, P. J. and Richardson, H. W. and Robertson, K. A. and Dibble, A. J. and Dalby, C. and Svanera, M.}, title = {{Diagnostic Labels and Measurement Timing Drive Systematic Inconsistency in ADNI Neuroimaging Data}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.16.752036}, url = {https://doi.org/10.64898/2026.09.16.752036} } @article{karaahmet2026-ff0d1134, author = {Karaahmet, B. and Lama, T. and Wang, A. and Cao, W. and Menon, V. and Klein, H. and Bennett, D. A. and De Jager, P. L. and others}, title = {{High-Dimensional Multi-Omic Mapping of Post-Mortem Human Brain Using Iterative Indirect Immunofluorescence Imaging on Xenium-Processed Tissues}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.16.751033}, url = {https://doi.org/10.64898/2026.09.16.751033} } @article{im2026-36cb393a, author = {Im, Y. and Kang, M. J. and Gutman, B. A. and Thomopoulos, S. I. and Thompson, P. M. and Ching, C. R. and {the Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Machine learning on subcortical brain features: A study of sample size efficiency for neurodegenerative disease classification}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.15.751847}, url = {https://doi.org/10.64898/2026.09.15.751847} } @article{hoang2026-cc41296c, author = {Hoang, D. T. and Thompson, R. C. and Lund, A. N. and Kritzer, E. and Buxbaum-Grice, A. S. and John, D. and Nadkarni, G. N. and Golestani, N. and others}, title = {{Surrogate variables and the risk of overfitting in neuropsychiatric gene expression analyses}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.05.756826}, url = {https://doi.org/10.64898/2026.10.05.756826} } @article{kim2026-9f5c4bb5, author = {Kim, Y. and Heo, W. and Park, S. J. and Cho, Y. E.}, title = {{A reproducibility-audit framework for generalizable versus dataset- specific molecular transition boundaries in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.24.746808}, url = {https://doi.org/10.64898/2026.08.24.746808} } @article{rosenberg2026-fc8eb3fa, author = {Rosenberg, A. M. and Tefera, E. and Gu, Z. and Borges, H. and Mansoor, A. and Shah, T. and Capozzi, G. and Barr, W. B. and others}, title = {{Spoken Recall Reveals Lexical and Mnemonic Function Differences in Temporal Lobe Epilepsy Patients}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.20.746093}, url = {https://doi.org/10.64898/2026.08.20.746093} } @article{radwan2026-18f8f9a3, author = {Radwan, M. and Lind, P. G. and Yazidi, A.}, title = {{Frequency-Resolved Connectivity Graphs for EEG-Based Classification of Alzheimer and Frontotemporal Dementia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.16.759776}, url = {https://doi.org/10.64898/2026.10.16.759776} } @article{zhu2026-4d9ec103, author = {Zhu, C. and Zhao, Z. and Song, B. and Chen, Y. and Xiao, Y. and Zhang, Z. and Ye, Y. and Xu, N. and others}, title = {{Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.17.752169}, url = {https://doi.org/10.64898/2026.09.17.752169} } @article{chang2026-9e6c52cd, author = {Chang, J. and Song, S. H.}, title = {{Specification dependence of EEG theta/alpha ratio associations with cognitive impairment: a multiverse analysis}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.03.749187}, url = {https://doi.org/10.64898/2026.09.03.749187} } @article{oh2026-4579e717, author = {Oh, H. S. and Downer, J. D. and Dietz, C. D. and Yballa, C. and Marcora, E. and Lario-Lago, A. and Heuer, H. W. and Forsberg, L. K. and others}, title = {{Cerebrospinal fluid YWHAG:NPTX2 ratio predicts clinical severity and future phenoconversion in frontotemporal lobar degeneration}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.22.746470}, url = {https://doi.org/10.64898/2026.08.22.746470} } @article{gebregergis2026-e5f490f6, author = {Gebregergis, B. T. and Yhdego, H. G. and Teklu, T.}, title = {{Reliability and disease sensitivity are dissociable properties of EEG foundation-model representations}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.19.745052}, url = {https://doi.org/10.64898/2026.08.19.745052} } @article{schreiner2026-ff9cb4d7, author = {Schreiner, S. and Miranda de la Maza, M. and Hammer, G. P. and Jeannelle, F. and Darricau, M. and Mirault, D. and Mechawar, N. and Bank, Netherlands Brain and others}, title = {{Disease-specific tangle immunophenotypes distinguish hippocampal vulnerability in Alzheimer’s disease and Parkinson’s disease dementia}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.13.744594}, url = {https://doi.org/10.64898/2026.08.13.744594} } @article{valledor2026-f87dce03, author = {Valledor, M. and Smith, K. and Lawrence, J. B. and Sosa, L. J.}, title = {{APP Dosage and Extracellular Domain Variants Drive Distinct Defects in Neurogenesis modeled in Down Syndrome iPS cells}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.05.742240}, url = {https://doi.org/10.64898/2026.08.05.742240} } @article{dooling2026-c6cd8c6a, author = {Dooling, B. R. and Vielle, A. and Lucero, E. M. and Rydland, C. and Quang, D. and Summers, R. and Esquer, H. and Coughlan, C. and others}, title = {{Trisomy 21 cerebral organoids exhibit Alzheimer’s disease amyloid and apolipoprotein E co-pathologies}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.07.01.735908}, url = {https://doi.org/10.64898/2026.07.01.735908} } @article{west2026-7b94cbdf, author = {West, N. R. and Lindberg, M. F. and Dairou, J. and MacGregor, S. and Puthireddy, S. and Meijer, L. and Bhattacharyya, A.}, title = {{Leucettinib-21 decreases dosage effects of DYRK1A in human trisomy 21 iPSC-derived neural cells}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.02.05.704014}, url = {https://doi.org/10.64898/2026.02.05.704014} } @article{pellegrini2026-99c7bc3a, author = {Pellegrini, C. and Ravaioli, F. and Fanti, S. D. and Sala, C. and Rochat, M. and Pollarini, V. and Barbara, P. and Pasti, A. and others}, title = {{Alterations of gut microbiota in Down syndrome and their association with Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.04.03.716276}, url = {https://doi.org/10.64898/2026.04.03.716276} } @article{sun2026-ff0edc6e, author = {Sun, C. and Thomas, R. and Stringer, C. and Galani, K. and Ho, L. and Sun, N. and Renfro, A. and Wright, S. and others}, title = {{Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome–associated Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.04.17.719050}, url = {https://doi.org/10.64898/2026.04.17.719050} } @article{zhu2025-0e640888, author = {Zhu, X. and Haure-Mirande, J. and Bicak, M. and Dong, P. and Kruglikov, I. and Al-subaie, A. and Fossati, V. and Noggle, S. and others}, title = {{miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2025}, doi = {10.1101/2025.09.28.679053}, url = {https://doi.org/10.1101/2025.09.28.679053} } @article{patel2025-c5fbe4fa, author = {Patel, D. and Rakowiecki, K. and Lazarov, O.}, title = {{Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer’s Disease phenotypes associated with Down Syndrome}}, journal = {bioRxiv}, year = {2025}, doi = {10.1101/2025.07.30.667706}, url = {https://doi.org/10.1101/2025.07.30.667706} } @article{reineke2025-81e24ed0, author = {Reineke, L. C. and Zhu, P. J. and Dalwadi, U. and Dooling, S. W. and Liu, Y. and Wang, I. and Young-Baird, S. and Okoh, J. and others}, title = {{Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction}}, journal = {bioRxiv}, year = {2025}, doi = {10.1101/2025.02.28.640897}, url = {https://doi.org/10.1101/2025.02.28.640897} } @article{mercado2026-398d9a8d, author = {Mercado, G. and Stetzik, L. and Schulz, E. and Meyerdirk, L. and Lindquist, A. and Cohen, L. and Escobar Galvis, M. L. and Steiner, J. A. and others}, title = {{Neuroinflammation is an early pathological process in a mouse model of prodromal Parkinsons disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.29.762888}, url = {https://doi.org/10.64898/2026.10.29.762888} } @article{zhang2026-7247d7cc, author = {Zhang, A. and Shen, W. and Yan, S. and Chen, J. and Liu, X. and Zou, J. and Li, S. and Hu, S. and others}, title = {{Cross-Tissue Inflammatory Convergence Supports a Putative Muscle–Brain Axis in Alzheimer’s Disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.07.751107}, url = {https://doi.org/10.64898/2026.10.07.751107} } @article{peledcohen2026-8c02bbe3, author = {Peled-Cohen, L. and Shmidov, A. and Rein, N. and Shapira, E. and Calderon, N. and Tikochinski, R. and Zeltzer, E. and Nathan, T. and others}, title = {{Dementia Language Models: a generalizable and controllable representation of cognitive impairment}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.16.752129}, url = {https://doi.org/10.64898/2026.09.16.752129} } @article{biglari2026-bb67e0bb, author = {Biglari, S. and Yeragi, E. and Bamisaye, D. and Gonzalez, C. and Garcia, R. and Losoya, A. and Arekere, A. D. and Payne, C. and others}, title = {{Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.08.750261}, url = {https://doi.org/10.64898/2026.09.08.750261} } @article{mathews2026-7aad1a5f, author = {Mathews, R. and Bouyadjera, S. B. and Donegan, J. J. and Havird, J. C.}, title = {{Mitochondrial DNA copy number in neurodegenerative diseases: a global meta-analysis of 156 comparisons across 76 studies}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.25.747144}, url = {https://doi.org/10.64898/2026.08.25.747144} } @article{he2026-3709d406, author = {He, Z. and Park, J. and Pulgrossi, R. C. and Lee, J. and Butler, R. R. and Weber, A. and Tian, L. and Zhang, X. and others}, title = {{Unlocking Sensitive Data with SPHERE in the Age of AI}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.09.01.748580}, url = {https://doi.org/10.64898/2026.09.01.748580} } @article{li2026-04732701, author = {Li, X. C. and Finney, C. A. and Shvetcov, A.}, title = {{Proteomic signatures of APOE ε4 across human tissues and cell types in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.27.746928}, url = {https://doi.org/10.64898/2026.08.27.746928} } @article{badea2026-d03e03f4, author = {Badea, A. and Acle, I. P. and Mendez de Inza, P. and Lin, H. and Anderson, R. J. and Johnson, K. G. and Whitson, H. E. and Song, A. W. and others}, title = {{Calibration-Aware and Interpretable Graph Learning for Multi-Cohort Diffusion Connectome Brain-Age Modeling}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.19.745783}, url = {https://doi.org/10.64898/2026.08.19.745783} } @article{lepcha2026-b6193857, author = {Lepcha, D. C. and Ali, A. and Martin, S. A. and Syed Abdul, S.}, title = {{Biomarker fidelity score: A quantitative framework for individual-level validation of explainability methods in 3D Alzheimer’s disease MRI classification}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.15.744687}, url = {https://doi.org/10.64898/2026.08.15.744687} } @article{shi2026-aaa991b3, author = {Shi, R. and Feingold, E. and Kamboh, M. I. and Fan, K.}, title = {{Optimizing Cognitive Phenotyping for Genetic Discovery in Alzheimer’s Disease: A Simulation-Based Evaluation of Mini-Mental State Examination-Based Decline Measures}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.16.759741}, url = {https://doi.org/10.64898/2026.10.16.759741} } @article{watanabe2026-72ba0f38, author = {Watanabe, N. and Ogawa, A. and Osada, T. and Adachi, Y. and Shirokoshi, T. and Kodama, H. and Oshima, Y. and Tanaka, S. and others}, title = {{Differential associations of insulin resistance with anterior hippocampal volume in mild cognitive impairment and Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.04.742662}, url = {https://doi.org/10.64898/2026.08.04.742662} } @article{acostamartinez2026-014f6f4c, author = {Acosta-Martínez, M. and Carter, V. and Nessim, A. and Murphy, S. and Dhawan, J. and Beach, T. G. and Serrano, G. E. and Sundermann, E. E. and others}, title = {{Sex-divergent trajectories of hippocampal and cortical NMDA receptor density across the Alzheimer’s disease continuum}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.08.05.743051}, url = {https://doi.org/10.64898/2026.08.05.743051} }