% alzhub.org library filter % Source: https://alzhub.org/research?journal=Nature % 156 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{eyting2025-40175543, author = {Eyting, M. and Xie, M. and Michalik, F. and Heß, S. and Chung, S. and Geldsetzer, P.}, title = {{A natural experiment on the effect of herpes zoster vaccination on dementia (Wales)}}, journal = {Nature}, year = {2025}, doi = {10.1038/s41586-025-08800-x}, pmid = {40175543}, url = {https://doi.org/10.1038/s41586-025-08800-x} } @article{mathys2024-39048816, author = {Mathys, H. and Boix, C. A. and Akay, L. A. and Xia, Z. and Davila-Velderrain, J. and Ng, A. P. and Jiang, X. and Abdelhady, G. and others}, title = {{Single-cell multiregion dissection of Alzheimer's disease}}, journal = {Nature}, year = {2024}, doi = {10.1038/s41586-024-07606-7}, pmid = {39048816}, url = {https://doi.org/10.1038/s41586-024-07606-7} } @article{liddelow2017-28099414, author = {Liddelow, Shane A. and Guttenplan, Kevin A. and Clarke, Laura E. and Bennett, F. Chris and Bohlen, Christopher J. and Schirmer, Lucas and Bennett, Mariko L. and Münch, Alexandra E. and others}, title = {{Neurotoxic reactive astrocytes are induced by activated microglia}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature21029}, pmid = {28099414}, url = {https://doi.org/10.1038/nature21029} } @article{meyerluehmann2008-18256671, author = {Meyer-Luehmann, M. and Spires-Jones, T. L. and Prada, C. and Garcia-Alloza, M. and de Calignon, A. and Rozkalne, A. and Koenigsknecht-Talboo, J. and Holtzman, D. M. and others}, title = {{Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease}}, journal = {Nature}, year = {2008}, doi = {10.1038/nature06616}, pmid = {18256671}, url = {https://doi.org/10.1038/nature06616} } @article{shi2017-28959956, author = {Shi, Y. and Yamada, K. and Liddelow, S. A. and Smith, S. T. and Zhao, L. and Luo, W. and Tsai, R. M. and Spina, S. and others}, title = {{ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature24016}, pmid = {28959956}, url = {https://doi.org/10.1038/nature24016} } @article{depp2023-37258678, author = {Depp, C. and Sun, T. and Sasmita, A. O. and Spieth, L. and Berghoff, S. A. and Nazarenko, T. and Overhoff, K. and Steixner-Kumar, A. A. and others}, title = {{Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease}}, journal = {Nature}, year = {2023}, doi = {10.1038/s41586-023-06120-6}, pmid = {37258678}, url = {https://doi.org/10.1038/s41586-023-06120-6} } @article{yang2022-36108674, author = {Yang, Y. and Shi, Y. and Schweighauser, M. and Zhang, X. and Kotecha, A. and Murzin, A. G. and Garringer, H. J. and Cullinane, P. W. and others}, title = {{Structures of α-synuclein filaments from human brains with Lewy pathology}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-05319-3}, pmid = {36108674}, url = {https://doi.org/10.1038/s41586-022-05319-3} } @article{hutton1998-9641683, author = {Hutton, M. and Lendon, C. L. and Rizzu, P. and Baker, M. and Froelich, S. and Houlden, H. and Pickering-Brown, S. and Chakraverty, S. and others}, title = {{Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17}}, journal = {Nature}, year = {1998}, doi = {10.1038/31508}, pmid = {9641683}, url = {https://doi.org/10.1038/31508} } @article{cruts2006-16862115, author = {Cruts, M. and Gijselinck, I. and van der Zee, J. and Engelborghs, S. and Wils, H. and Pirici, D. and Rademakers, R. and others}, title = {{Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21}}, journal = {Nature}, year = {2006}, doi = {10.1038/nature05017}, pmid = {16862115}, url = {https://doi.org/10.1038/nature05017} } @article{ma2022-35197626, author = {Ma, X. R. and Prudencio, M. and Koike, Y. and Vatsavayai, S. C. and Kim, G. and Harbinski, F. and Briner, A. and Rodriguez, C. M. and others}, title = {{TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-04424-7}, pmid = {35197626}, url = {https://doi.org/10.1038/s41586-022-04424-7} } @article{brown2022-35197628, author = {Brown, A. L. and Wilkins, O. G. and Keuss, M. J. and Kargbo-Hill, S. E. and Zanovello, M. and Lee, W. C. and Bampton, A. and Lee, F. C. Y. and others}, title = {{TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-04436-3}, pmid = {35197628}, url = {https://doi.org/10.1038/s41586-022-04436-3} } @article{ramachandran2019-31597160, author = {Ramachandran, P. and Dobie, R. and Wilson-Kanamori, JR. and Dora, E. F. and Henderson, B. E. P. and Luu, N. T. and Portman, JR. and Matchett, K. P. and others}, title = {{Resolving the fibrotic niche of human liver cirrhosis at single-cell level}}, journal = {Nature}, year = {2019}, doi = {10.1038/s41586-019-1631-3}, pmid = {31597160}, url = {https://doi.org/10.1038/s41586-019-1631-3} } @article{sherrington1995-7596406, author = {Sherrington, Robin P. and Rogaev, Evgeny Ivanovich and Liang, Yuh‐Jin and Rogaeva, Ekaterina A. and Lévesque, Georges and Ikeda, Masaki and Chi, H. and Lin, Chiao‐Feng and others}, title = {{Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease}}, journal = {Nature}, year = {1995}, doi = {10.1038/375754a0}, pmid = {7596406}, url = {https://doi.org/10.1038/375754a0} } @article{mathys2019-31042697, author = {Mathys, Hansruedi and Dávila-Velderrain, José and Peng, Zhuyu and Gao, Fan and Mohammadi, Shahin and Young, Jennie Z. and Menon, Madhvi and He, Liang and Abdurrob, Fatema and Jiang, Xueqiao and Martorell, Anthony J. and Ransohoff, Richard M. and Hafler, Brian P. and Bennett, David Alan and Kellis, Manolis and Tsai, Li‐Huei}, title = {{Single-cell transcriptomic analysis of Alzheimer’s disease}}, journal = {Nature}, year = {2019}, doi = {10.1038/s41586-019-1195-2}, pmid = {31042697}, url = {https://doi.org/10.1038/s41586-019-1195-2} } @article{shi2021-34588692, author = {Shi, Y. and Zhang, W. and Yang, Y. and Murzin, A. G. and Falcon, B. and Kotecha, A. and van Beers, M. and Tarutani, A. and others}, title = {{Structure-based classification of tauopathies}}, journal = {Nature}, year = {2021}, doi = {10.1038/s41586-021-03911-7}, pmid = {34588692}, url = {https://doi.org/10.1038/s41586-021-03911-7} } @article{rauch2020-32296178, author = {Rauch, J. N. and Luna, G. and Guzman, E. and Audouard, M. and Challis, C. and Sibih, Y. E. and Leshuk, C. and Hernandez, I. and others}, title = {{LRP1 is a master regulator of tau uptake and spread}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-020-2156-5}, pmid = {32296178}, url = {https://doi.org/10.1038/s41586-020-2156-5} } @article{goate1991-1671712, author = {Goate, Alison and Chartier‐Harlin, Marie‐Christine and Mullan, Mike and Brown, Jeremy and Crawford, Fiona and Fidani, Liana and Giuffra, Luis A. and Haynes, Andrew R. and others}, title = {{Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease}}, journal = {Nature}, year = {1991}, doi = {10.1038/349704a0}, pmid = {1671712}, url = {https://doi.org/10.1038/349704a0} } @article{bycroft2018-30305743, author = {Bycroft, Clare and Freeman, Colin and Petkova, Desislava and Band, Gavin and Elliott, Lloyd T. and Sharp, Kevin and Motyer, Allan and Vukcevic, Damjan and Delaneau, Olivier and O’Connell, Jared and Cortés, Adrián and Welsh, Samantha and Young, Alan and Effingham, Mark and McVean, Gil and Leslie, Stephen and Allen, Naomi E. and Donnelly, Peter and Marchini, Jonathan}, title = {{The UK Biobank resource with deep phenotyping and genomic data}}, journal = {Nature}, year = {2018}, doi = {10.1038/s41586-018-0579-z}, pmid = {30305743}, url = {https://doi.org/10.1038/s41586-018-0579-z} } @article{ising2019-31748742, author = {Ising, Christina and Venegas, Carmen and Zhang, Shuangshuang and Scheiblich, Hannah and Schmidt, Susanne V. and Vieira-Saecker, Ana Maria Menezes and Schwartz, Stephanie and Albasset, Shadi and McManus, Róisín M. and Tejera, Darío and Griep, Angelika and Santarelli, Francesco and Brosseron, Frederic and Opitz, Sabine and Stunden, James and Merten, Maximilian and Kayed, Rakez and Golenbock, Douglas Taylor and Blum, David L and Latz, Eicke and Buée, Luc and Heneka, Michael Thomas}, title = {{NLRP3 inflammasome activation drives tau pathology}}, journal = {Nature}, year = {2019}, doi = {10.1038/s41586-019-1769-z}, pmid = {31748742}, url = {https://doi.org/10.1038/s41586-019-1769-z} } @article{heneka2013-23254930, author = {Heneka, M. T. and Kummer, M. P. and Stutz, A. and Delekate, A. and Schwartz, S. and Vieira-Saecker, A. and Griep, A. and Axt, D. and others}, title = {{NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice}}, journal = {Nature}, year = {2013}, doi = {10.1038/nature11729}, pmid = {23254930}, url = {https://doi.org/10.1038/nature11729} } @article{deng2011-21857683, author = {Deng, H. X. and Chen, W. and Hong, S. T. and Boycott, K. M. and Gorrie, G. H. and Siddique, N. and Yang, Y. and Fecto, F. and others}, title = {{Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia}}, journal = {Nature}, year = {2011}, doi = {10.1038/nature10353}, pmid = {21857683}, url = {https://doi.org/10.1038/nature10353} } @article{garciaalonso2022-35794482, author = {Garcia-Alonso, L. and Lorenzi, V. and Mazzeo, C. I. and Alves-Lopes, J. P. and Roberts, K. and Sancho-Serra, C. and Engelbert, J. and Marečková, M. and others}, title = {{Single-cell roadmap of human gonadal development}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-04918-4}, pmid = {35794482}, url = {https://doi.org/10.1038/s41586-022-04918-4} } @article{oh2023-38057571, author = {Oh, H. S. and Rutledge, J. and Nachun, D. and Pálovics, R. and Abiose, O. and Moran-Losada, P. and Channappa, D. and Urey, D. Y. and others}, title = {{Organ aging signatures in the plasma proteome track health and disease}}, journal = {Nature}, year = {2023}, doi = {10.1038/s41586-023-06802-1}, pmid = {38057571}, url = {https://doi.org/10.1038/s41586-023-06802-1} } @article{shahnawaz2020-32025029, author = {Shahnawaz, M. and Mukherjee, A. and Pritzkow, S. and Mendez, N. and Rabadia, P. and Liu, X. and Hu, B. and Schmeichel, A. and others}, title = {{Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-020-1984-7}, pmid = {32025029}, url = {https://doi.org/10.1038/s41586-020-1984-7} } @article{jonsson2012-22801501, author = {Jonsson, T. and Atwal, J. K. and Steinberg, S. and Snaedal, J. and Jonsson, P. V. and Bjornsson, S. and Stefansson, H. and Sulem, P. and others}, title = {{A mutation in APP protects against Alzheimer's disease and age-related cognitive decline}}, journal = {Nature}, year = {2012}, doi = {10.1038/nature11283}, pmid = {22801501}, url = {https://doi.org/10.1038/nature11283} } @article{bell2012-22622580, author = {Bell, R. D. and Winkler, E. A. and Singh, I. and Sagare, A. P. and Deane, R. and Wu, Z. and Holtzman, D. M. and Betsholtz, C. and others}, title = {{Apolipoprotein E controls cerebrovascular integrity via cyclophilin A}}, journal = {Nature}, year = {2012}, doi = {10.1038/nature11087}, pmid = {22622580}, url = {https://doi.org/10.1038/nature11087} } @article{baker2006-16862116, author = {Baker, M. and Mackenzie, I. R. and Pickering-Brown, S. M. and Gass, J. and Rademakers, R. and Lindholm, C. and Snowden, J. and Adamson, J. and others}, title = {{Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17}}, journal = {Nature}, year = {2006}, doi = {10.1038/nature05016}, pmid = {16862116}, url = {https://doi.org/10.1038/nature05016} } @article{falcon2018-30158706, author = {Falcon, B. and Zhang, W. and Murzin, A. G. and Murshudov, G. and Garringer, H. J. and Vidal, R. and Crowther, R. A. and Ghetti, B. and others}, title = {{Structures of filaments from Pick's disease reveal a novel tau protein fold}}, journal = {Nature}, year = {2018}, doi = {10.1038/s41586-018-0454-y}, pmid = {30158706}, url = {https://doi.org/10.1038/s41586-018-0454-y} } @article{lu2014-24670762, author = {Lu, T. and Aron, L. and Zullo, J. and Pan, Y. and Kim, H. and Chen, Y. and Yang, T. H. and Kim, H. M. and others}, title = {{REST and stress resistance in ageing and Alzheimer's disease}}, journal = {Nature}, year = {2014}, doi = {10.1038/nature13163}, pmid = {24670762}, url = {https://doi.org/10.1038/nature13163} } @article{becker2017-28405022, author = {Becker, L. A. and Huang, B. and Bieri, G. and Ma, R. and Knowles, D. A. and Jafar-Nejad, P. and Messing, J. and Kim, H. J. and others}, title = {{Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature22038}, pmid = {28405022}, url = {https://doi.org/10.1038/nature22038} } @article{damesquita2021-33911285, author = {Da Mesquita, S. and Papadopoulos, Z. and Dykstra, T. and Brase, L. and Farias, F. G. and Wall, M. and Jiang, H. and Kodira, C. D. and others}, title = {{Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy}}, journal = {Nature}, year = {2021}, doi = {10.1038/s41586-021-03489-0}, pmid = {33911285}, url = {https://doi.org/10.1038/s41586-021-03489-0} } @article{aarsland2025-41407852, author = {Aarsland, Dag and Sunde, Anita Lenora and Tovar, Diego and Leuzy, Antoine and Fladby, Tormod and Zetterberg, Henrik and Blennow, Kaj and Tan, Kübra and others}, title = {{Prevalence of Alzheimer’s disease pathology in the community}}, journal = {Nature}, year = {2025}, doi = {10.1038/s41586-025-09841-y}, pmid = {41407852}, url = {https://doi.org/10.1038/s41586-025-09841-y} } @article{peng2018-29743672, author = {Peng, C. and Gathagan, R. J. and Covell, D. J. and Medellin, C. and Stieber, A. and Robinson, J. L. and Zhang, B. and Pitkin, R. M. and others}, title = {{Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies}}, journal = {Nature}, year = {2018}, doi = {10.1038/s41586-018-0104-4}, pmid = {29743672}, url = {https://doi.org/10.1038/s41586-018-0104-4} } @article{green2024-39198642, author = {Green, G. S. and Fujita, M. and Yang, H. S. and Taga, M. and Cain, A. and McCabe, C. and Comandante-Lou, N. and White, C. C. and others}, title = {{Cellular communities reveal trajectories of brain ageing and Alzheimer's disease}}, journal = {Nature}, year = {2024}, doi = {10.1038/s41586-024-07871-6}, pmid = {39198642}, url = {https://doi.org/10.1038/s41586-024-07871-6} } @article{sevigny2016-27582220, author = {Sevigny, Jeff and Chiao, Ping and Bussière, Thierry and Weinreb, Paul H. and Williams, Leslie J. and Maier, Marcel and Dunstan, Robert W. and Salloway, Stephen and others}, title = {{The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease}}, journal = {Nature}, year = {2016}, doi = {10.1038/nature19323}, pmid = {27582220}, url = {https://doi.org/10.1038/nature19323} } @article{walsh2002-11932745, author = {Walsh, Dominic M. and Klyubin, Igor V. and Fadeeva, Julia V. and Cullen, William K. and Anwyl, Roger and Wolfe, Michael S. and Rowan, Michael J. and Selkoe, Dennis J.}, title = {{Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo}}, journal = {Nature}, year = {2002}, doi = {10.1038/416535a}, pmid = {11932745}, url = {https://doi.org/10.1038/416535a} } @article{nakamura2018-29420472, author = {Nakamura, Akinori and Kaneko, Naoki and Villemagne, Victor L. and Kato, Takashi and Doecke, James D. and Doré, Vincent and Fowler, Christopher James and Li, Qiao‐Xin and Martins, Ralph Nigel and Rowe, Christopher Cleon and Tomita, Taisuke and Matsuzaki, Katsumi and Ishii, Kenji and Ishii, Kazunari and Arahata, Yutaka and Iwamoto, Shinichi and Ito, Kengo and Tanaka, Koichi and Masters, Colin Louis and Yanagisawa, Katsuhiko}, title = {{High performance plasma amyloid-β biomarkers for Alzheimer’s disease}}, journal = {Nature}, year = {2018}, doi = {10.1038/nature25456}, pmid = {29420472}, url = {https://doi.org/10.1038/nature25456} } @article{spillantini1997-9278044, author = {Spillantini, Maria Grazia and Schmidt, Marie Luise and Lee, Virginia M.‐Y. and Trojanowski, John Q. and Jakes, Ross and Goedert, Michel}, title = {{α-Synuclein in Lewy bodies}}, journal = {Nature}, year = {1997}, doi = {10.1038/42166}, pmid = {9278044}, url = {https://doi.org/10.1038/42166} } @article{kimura2025-40205047, author = {Kimura, K. and Subramanian, A. and Yin, Z. and Khalilnezhad, A. and Wu, Y. and He, D. and Dixon, K. O. and Chitta, U. K. and Ding, X. and Adhikari, N. and Guzchenko, I. and Zhang, X. and others}, title = {{Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease}}, journal = {Nature}, year = {2025}, doi = {10.1038/s41586-025-08852-z}, pmid = {40205047}, url = {https://doi.org/10.1038/s41586-025-08852-z} } @article{falcon2019-30894745, author = {Falcon, B. and Zivanov, J. and Zhang, W. and Murzin, A. G. and Garringer, H. J. and Vidal, R. and Crowther, R. A. and Newell, K. L. and others}, title = {{Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules}}, journal = {Nature}, year = {2019}, doi = {10.1038/s41586-019-1026-5}, pmid = {30894745}, url = {https://doi.org/10.1038/s41586-019-1026-5} } @article{games1995-7845465, author = {Games, D. and Adams, D. and Alessandrini, R. and Barbour, R. and Berthelette, P. and Blackwell, C. and Carr, T. and Clemens, J. and others}, title = {{Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein}}, journal = {Nature}, year = {1995}, doi = {10.1038/373523a0}, pmid = {7845465}, url = {https://doi.org/10.1038/373523a0} } @article{willem2015-26322584, author = {Willem, M. and Tahirovic, S. and Busche, M. A. and Ovsepian, S. V. and Chafai, M. and Kootar, S. and Hornburg, D. and Evans, L. D. and others}, title = {{η-Secretase processing of APP inhibits neuronal activity in the hippocampus}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14864}, pmid = {26322584}, url = {https://doi.org/10.1038/nature14864} } @article{schroer2023-37587343, author = {Schroer, A. B. and Ventura, P. B. and Sucharov, J. and Misra, R. and Chui, M. K. K. and Bieri, G. and Horowitz, A. M. and Smith, L. K. and others}, title = {{Platelet factors attenuate inflammation and rescue cognition in ageing}}, journal = {Nature}, year = {2023}, doi = {10.1038/s41586-023-06436-3}, pmid = {37587343}, url = {https://doi.org/10.1038/s41586-023-06436-3} } @article{rogaev1995-7651536, author = {Rogaev, Evgeny Ivanovich and Sherrington, Robin P. and Rogaeva, Ekaterina A. and Lévesque, Georges and Ikeda, Masaki and Liang, Yuh‐Jin and Chi, H. and Lin, Chen-Xi and Holman, K. and Tsuda, Takuya and Mar, Lynn and Sorbi, Sandro and Nacmias, Benedetta and Piacentini, Silvia and Amaducci, L. A. and Chumakov, Ilya M. and Cohen, Daniel Blair and Lannfelt, Lars and Fraser, Paul E. and Rommens, Johanna M. and George‐Hyslop, Peter St}, title = {{Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene}}, journal = {Nature}, year = {1995}, doi = {10.1038/376775a0}, pmid = {7651536}, url = {https://doi.org/10.1038/376775a0} } @article{wolfe1999-10206644, author = {Wolfe, Michael S. and Xia, Weiming and Ostaszewski, Beth L. and Diehl, Thekla S. and Kimberly, William Taylor and Selkoe, Dennis J.}, title = {{Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity}}, journal = {Nature}, year = {1999}, doi = {10.1038/19077}, pmid = {10206644}, url = {https://doi.org/10.1038/19077} } @article{morgan2000-11140686, author = {Morgan, D. and Diamond, D. M. and Gottschall, P. E. and Ugen, K. E. and Dickey, C. and Hardy, J. and Duff, K. and Jantzen, P. and others}, title = {{A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease}}, journal = {Nature}, year = {2000}, doi = {10.1038/35050116}, pmid = {11140686}, url = {https://doi.org/10.1038/35050116} } @article{joutel1996-8878478, author = {Joutel, A. and Corpechot, C. and Ducros, A. and Vahedi, K. and Chabriat, H. and Mouton, P. and Alamowitch, S. and Domenga, V. and others}, title = {{Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia}}, journal = {Nature}, year = {1996}, doi = {10.1038/383707a0}, pmid = {8878478}, url = {https://doi.org/10.1038/383707a0} } @article{freibaum2015-26308899, author = {Freibaum, B. D. and Lu, Y. and Lopez-Gonzalez, R. and Kim, N. C. and Almeida, S. and Lee, K. H. and Badders, N. and Valentine, M. and others}, title = {{GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14974}, pmid = {26308899}, url = {https://doi.org/10.1038/nature14974} } @article{arseni2022-34880495, author = {Arseni, D. and Hasegawa, M. and Murzin, A. G. and Kametani, F. and Arai, M. and Yoshida, M. and Ryskeldi-Falcon, B.}, title = {{Structure of pathological TDP-43 filaments from ALS with FTLD}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-021-04199-3}, pmid = {34880495}, url = {https://doi.org/10.1038/s41586-021-04199-3} } @article{hur2020-32879487, author = {Hur, J. Y. and Frost, G. R. and Wu, X. and Crump, C. and Pan, S. J. and Wong, E. and Barros, M. and Li, T. and others}, title = {{The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-020-2681-2}, pmid = {32879487}, url = {https://doi.org/10.1038/s41586-020-2681-2} } @article{kaul2001-11309629, author = {Kaul, M. and Garden, G. A. and Lipton, S. A.}, title = {{Pathways to neuronal injury and apoptosis in HIV-associated dementia}}, journal = {Nature}, year = {2001}, doi = {10.1038/35073667}, pmid = {11309629}, url = {https://doi.org/10.1038/35073667} } @article{kang1987-2881207, author = {Kang, Jie and Lemaire, Hans-George and Unterbeck, Axel and Salbaum, J. Michael and Masters, Colin Louis and Grzeschik, Karl‐Heinz and Multhaup, Gerd and Beyreuther, Konrad T. and others}, title = {{The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor}}, journal = {Nature}, year = {1987}, doi = {10.1038/325733a0}, pmid = {2881207}, url = {https://doi.org/10.1038/325733a0} } @article{haass1992-1383826, author = {Haass, Christian and Schlossmacher, Michael G. and Hung, Albert Y. and Vigo‐Pelfrey, Carmen and Mellon, Angela and Ostaszewski, Beth L. and Lieberburg, Ivan M. and Koo, Edward H. and Schenk, Dale and Teplow, David B. and Selkoe, Dennis J.}, title = {{Amyloid β-peptide is produced by cultured cells during normal metabolism}}, journal = {Nature}, year = {1992}, doi = {10.1038/359322a0}, pmid = {1383826}, url = {https://doi.org/10.1038/359322a0} } @article{citron1992-1465129, author = {Citron, Martin and Oltersdorf, Tilman and Haass, Christian and McConlogue, Lisa and Hung, Albert Y. and Seubert, Peter A. and Vigo‐Pelfrey, Carmen and Lieberburg, Ivan M. and Selkoe, Dennis J.}, title = {{Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production}}, journal = {Nature}, year = {1992}, doi = {10.1038/360672a0}, pmid = {1465129}, url = {https://doi.org/10.1038/360672a0} } @article{duyan1996-8751438, author = {Du Yan, Shi and Chen, Xi and Fu, Jin and Chen, Ming and Zhu, Huaijie and Roher, Alex E. and Slattery, Timothy and Zhao, Lei and Nagashima, Mariko and Morser, John and Migheli, Antonio and Nawroth, Peter P. and Stern, David M. and Schmidt, Ann Marie}, title = {{RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease}}, journal = {Nature}, year = {1996}, doi = {10.1038/382685a0}, pmid = {8751438}, url = {https://doi.org/10.1038/382685a0} } @article{ma1994-7969426, author = {Ma, J. and Yee, A. and Brewer, H. B. and Das, S. and Potter, H.}, title = {{Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments}}, journal = {Nature}, year = {1994}, doi = {10.1038/372092a0}, pmid = {7969426}, url = {https://doi.org/10.1038/372092a0} } @article{perrin2009-19829371, author = {Perrin, R. J. and Fagan, A. M. and Holtzman, D. M.}, title = {{Multimodal techniques for diagnosis and prognosis of Alzheimer's disease}}, journal = {Nature}, year = {2009}, doi = {10.1038/nature08538}, pmid = {19829371}, url = {https://doi.org/10.1038/nature08538} } @article{zhang2015-26308891, author = {Zhang, K. and Donnelly, C. J. and Haeusler, A. R. and Grima, J. C. and Machamer, J. B. and Steinwald, P. and Daley, E. L. and Miller, S. J. and others}, title = {{The C9orf72 repeat expansion disrupts nucleocytoplasmic transport}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14973}, pmid = {26308891}, url = {https://doi.org/10.1038/nature14973} } @article{haeusler2014-24598541, author = {Haeusler, A. R. and Donnelly, C. J. and Periz, G. and Simko, E. A. and Shaw, P. G. and Kim, M. S. and Maragakis, N. J. and Troncoso, J. C. and others}, title = {{C9orf72 nucleotide repeat structures initiate molecular cascades of disease}}, journal = {Nature}, year = {2014}, doi = {10.1038/nature13124}, pmid = {24598541}, url = {https://doi.org/10.1038/nature13124} } @article{schenk1999-10408445, author = {Schenk, D. and Barbour, R. and Dunn, W. and Gordon, G. and Grajeda, H. and Guido, T. and Hu, K. and Huang, J. and others}, title = {{Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse}}, journal = {Nature}, year = {1999}, doi = {10.1038/22124}, pmid = {10408445}, url = {https://doi.org/10.1038/22124} } @article{tanzi1988-2893290, author = {Tanzi, Rudolph E. and McClatchey, Andrea I. and Lamperti, Edward D. and Villa‐Komaroff, Lydia and Gusella, James F. and Neve, Rachael L.}, title = {{Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease}}, journal = {Nature}, year = {1988}, doi = {10.1038/331528a0}, pmid = {2893290}, url = {https://doi.org/10.1038/331528a0} } @article{weggen2001-11700559, author = {Weggen, Sascha and Eriksen, Jason L. and Das, Pritam and Sagi, Sarah A. and Wang, Rong and Pietrzik, Claus U. and Findlay, Kirk A. and Smith, Tawnya E. and Murphy, Michael P. and Bülter, Thomas and Kang, David E. and Marquez-Sterling, Numa R. and Golde, Todd Eliot and Koo, Edward H.}, title = {{A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity}}, journal = {Nature}, year = {2001}, doi = {10.1038/35102591}, pmid = {11700559}, url = {https://doi.org/10.1038/35102591} } @article{hibar2015-25607358, author = {Hibar, D. P. and Stein, J. L. and Renteria, M. E. and Arias-Vasquez, A. and Desrivières, S. and Jahanshad, N. and Toro, R. and Wittfeld, K. and others}, title = {{Common genetic variants influence human subcortical brain structures}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14101}, pmid = {25607358}, url = {https://doi.org/10.1038/nature14101} } @article{burberry2020-32483373, author = {Burberry, A. and Wells, M. F. and Limone, F. and Couto, A. and Smith, K. S. and Keaney, J. and Gillet, G. and van Gastel, N. and others}, title = {{C9orf72 suppresses systemic and neural inflammation induced by gut bacteria}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-020-2288-7}, pmid = {32483373}, url = {https://doi.org/10.1038/s41586-020-2288-7} } @article{decalignon2010-20357768, author = {de Calignon, A. and Fox, L. M. and Pitstick, R. and Carlson, G. A. and Bacskai, B. J. and Spires-Jones, T. L. and Hyman, B. T.}, title = {{Caspase activation precedes and leads to tangles}}, journal = {Nature}, year = {2010}, doi = {10.1038/nature08890}, pmid = {20357768}, url = {https://doi.org/10.1038/nature08890} } @article{cisse2011-21113149, author = {Cissé, M. and Halabisky, B. and Harris, J. and Devidze, N. and Dubal, D. B. and Sun, B. and Orr, A. and Lotz, G. and others}, title = {{Reversing EphB2 depletion rescues cognitive functions in Alzheimer model}}, journal = {Nature}, year = {2011}, doi = {10.1038/nature09635}, pmid = {21113149}, url = {https://doi.org/10.1038/nature09635} } @article{he1997-9024664, author = {He, J. and Chen, Y. and Farzan, M. and Choe, H. and Ohagen, A. and Gartner, S. and Busciglio, J. and Yang, X. and others}, title = {{CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia}}, journal = {Nature}, year = {1997}, doi = {10.1038/385645a0}, pmid = {9024664}, url = {https://doi.org/10.1038/385645a0} } @article{stgeorgehyslop1990-2395471, author = {St George-Hyslop, P. H. and Haines, J. L. and Farrer, L. A. and Polinsky, R. and Van Broeckhoven, C. and Goate, A. and McLachlan, D. R. and Orr, H. and others}, title = {{Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder}}, journal = {Nature}, year = {1990}, doi = {10.1038/347194a0}, pmid = {2395471}, url = {https://doi.org/10.1038/347194a0} } @article{cruchaga2014-24336208, author = {Cruchaga, C. and Karch, C. M. and Jin, S. C. and Benitez, B. A. and Cai, Y. and Guerreiro, R. and Harari, O. and Norton, J. and others}, title = {{Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease}}, journal = {Nature}, year = {2014}, doi = {10.1038/nature12825}, pmid = {24336208}, url = {https://doi.org/10.1038/nature12825} } @article{faraco2019-31645758, author = {Faraco, G. and Hochrainer, K. and Segarra, S. G. and Schaeffer, S. and Santisteban, M. M. and Menon, A. and Jiang, H. and Holtzman, D. M. and others}, title = {{Dietary salt promotes cognitive impairment through tau phosphorylation}}, journal = {Nature}, year = {2019}, doi = {10.1038/s41586-019-1688-z}, pmid = {31645758}, url = {https://doi.org/10.1038/s41586-019-1688-z} } @article{hsiao1989-2564168, author = {Hsiao, K. and Baker, H. F. and Crow, T. J. and Poulter, M. and Owen, F. and Terwilliger, J. D. and Westaway, D. and Ott, J. and others}, title = {{Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome}}, journal = {Nature}, year = {1989}, doi = {10.1038/338342a0}, pmid = {2564168}, url = {https://doi.org/10.1038/338342a0} } @article{vanveen2020-31996848, author = {van Veen, S. and Martin, S. and Van den Haute, C. and Benoy, V. and Lyons, J. and Vanhoutte, R. and Kahler, J. P. and Decuypere, J. P. and others}, title = {{ATP13A2 deficiency disrupts lysosomal polyamine export}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-020-1968-7}, pmid = {31996848}, url = {https://doi.org/10.1038/s41586-020-1968-7} } @article{vidal1999-10391242, author = {Vidal, R. and Frangione, B. and Rostagno, A. and Mead, S. and Révész, T. and Plant, G. and Ghiso, J.}, title = {{A stop-codon mutation in the BRI gene associated with familial British dementia}}, journal = {Nature}, year = {1999}, doi = {10.1038/21637}, pmid = {10391242}, url = {https://doi.org/10.1038/21637} } @article{lee2026-42778699, author = {Lee, Donghoon and Koutrouli, Mikaela and Masse, Nicolas Y. and Hoffman, Gabriel E. and Kinrot, Seon and Wang, Xinyi and Prashant, N. M. and Pjanic, Milos and others}, title = {{Single-cell atlas of transcriptomic vulnerability across brain disorders}}, journal = {Nature}, year = {2026}, doi = {10.1038/s41586-025-09573-z}, pmid = {42778699}, url = {https://doi.org/10.1038/s41586-025-09573-z} } @article{sinha1999-10591214, author = {Sinha, Sukanto and Anderson, John P. and Barbour, Robin and Basi, Guriqbal S. and Caccavello, Russell J. and Davis, David L. and Doan, Minhtam and Dovey, Harry F. and Frigon, Normand L. and Hong, Jin and Jacobson-Croak, Kirsten and Jewett, Nancy E. and Keim, Pamela S. and Knops, Jeroen and Lieberburg, Ivan M. and Power, Michael D. and Tan, Hua Tiang and Tatsuno, Gwen P. and Tung, Jay S. and Schenk, Dale and Seubert, Peter A. and Suomensaari, Susanna and Wang, Shuwen and Walker, Donald E. and Zhao, Jun Wei and McConlogue, Lisa and John, Varghese}, title = {{Purification and cloning of amyloid precursor protein β-secretase from human brain}}, journal = {Nature}, year = {1999}, doi = {10.1038/990114}, pmid = {10591214}, url = {https://doi.org/10.1038/990114} } @article{yan1999-10591213, author = {Yan, Riqiang and Bienkowski, Michael J. and Shuck, Mary E. and Miao, Huiyi and Tory, Monica C. and Pauley, Adele M. and Brashler, John R. and Stratman, Nancy C. and Mathews, W. Rodney and Buhl, Allen E. and Carter, Donald B. and Tomasselli, Alfredo G. and Parodi, Luis A. and Heinrikson, Robert L. and Gurney, Mark E.}, title = {{Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity}}, journal = {Nature}, year = {1999}, doi = {10.1038/990107}, pmid = {10591213}, url = {https://doi.org/10.1038/990107} } @article{zhang2020-32050258, author = {Zhang, W. and Tarutani, A. and Newell, K. L. and Murzin, A. G. and Matsubara, T. and Falcon, B. and Vidal, R. and Garringer, H. J. and others}, title = {{Novel tau filament fold in corticobasal degeneration}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-020-2043-0}, pmid = {32050258}, url = {https://doi.org/10.1038/s41586-020-2043-0} } @article{barger1997-9278049, author = {Barger, S. W. and Harmon, A. D.}, title = {{Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E}}, journal = {Nature}, year = {1997}, doi = {10.1038/42257}, pmid = {9278049}, url = {https://doi.org/10.1038/42257} } @article{haney2024-38480892, author = {Haney, M. S. and Pálovics, R. and Munson, C. N. and Long, C. and Johansson, P. K. and Yip, O. and Dong, W. and Rawat, E. and others}, title = {{APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia}}, journal = {Nature}, year = {2024}, doi = {10.1038/s41586-024-07185-7}, pmid = {38480892}, url = {https://doi.org/10.1038/s41586-024-07185-7} } @article{murdock2024-38418876, author = {Murdock, M. H. and Yang, C. Y. and Sun, N. and Pao, P. C. and Blanco-Duque, C. and Kahn, M. C. and Kim, T. and Lavoie, N. S. and others}, title = {{Multisensory gamma stimulation promotes glymphatic clearance of amyloid}}, journal = {Nature}, year = {2024}, doi = {10.1038/s41586-024-07132-6}, pmid = {38418876}, url = {https://doi.org/10.1038/s41586-024-07132-6} } @article{disouky2026-41741649, author = {Disouky, Ahmed and Sanborn, Mark A and Sabitha, K R and Mostafa, Mostafa M and Ayala, Ivan Alejandro and Bennett, David A and Lu, Yisha and Zhou, Yi and others}, title = {{Human hippocampal neurogenesis in adulthood, ageing and Alzheimer's disease}}, journal = {Nature}, year = {2026}, doi = {10.1038/s41586-026-10169-4}, pmid = {41741649}, url = {https://doi.org/10.1038/s41586-026-10169-4} } @article{nalbantoglu1997-9168112, author = {Nalbantoglu, J. and Tirado-Santiago, G. and Lahsaïni, A. and Poirier, J. and Goncalves, O. and Verge, G. and Momoli, F. and Welner, S. A. and others}, title = {{Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein}}, journal = {Nature}, year = {1997}, doi = {10.1038/387500a0}, pmid = {9168112}, url = {https://doi.org/10.1038/387500a0} } @article{berg2021-34616067, author = {Berg, J. and Sorensen, S. A. and Ting, J. T. and Miller, J. A. and Chartrand, T. and Buchin, A. and Bakken, T. E. and Budzillo, A. and others}, title = {{Human neocortical expansion involves glutamatergic neuron diversification}}, journal = {Nature}, year = {2021}, doi = {10.1038/s41586-021-03813-8}, pmid = {34616067}, url = {https://doi.org/10.1038/s41586-021-03813-8} } @article{yuan2022-36450991, author = {Yuan, P. and Zhang, M. and Tong, L. and Morse, T. M. and McDougal, R. A. and Ding, H. and Chan, D. and Cai, Y. and others}, title = {{PLD3 affects axonal spheroids and network defects in Alzheimer's disease}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-05491-6}, pmid = {36450991}, url = {https://doi.org/10.1038/s41586-022-05491-6} } @article{damesquita2018-30046111, author = {Da Mesquita, S. and Louveau, A. and Vaccari, A. and Smirnov, I. and Cornelison, R. C. and Kingsmore, K. M. and Contarino, C. and Onengut-Gumuscu, S. and others}, title = {{Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease}}, journal = {Nature}, year = {2018}, doi = {10.1038/s41586-018-0368-8}, pmid = {30046111}, url = {https://doi.org/10.1038/s41586-018-0368-8} } @article{montagne2020-32376954, author = {Montagne, A. and Nation, D. A. and Sagare, A. P. and Barisano, G. and Sweeney, M. D. and Chakhoyan, A. and Pachicano, M. and Joe, E. and others}, title = {{APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-020-2247-3}, pmid = {32376954}, url = {https://doi.org/10.1038/s41586-020-2247-3} } @article{gate2020-31915375, author = {Gate, D. and Saligrama, N. and Leventhal, O. and Yang, A. C. and Unger, M. S. and Middeldorp, J. and Chen, K. and Lehallier, B. and others}, title = {{Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-019-1895-7}, pmid = {31915375}, url = {https://doi.org/10.1038/s41586-019-1895-7} } @article{chartierharlin1991-1944558, author = {Chartier-Harlin, M. C. and Crawford, F. and Houlden, H. and Warren, A. and Hughes, D. and Fidani, L. and Goate, A. and Rossor, M. and others}, title = {{Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene}}, journal = {Nature}, year = {1991}, doi = {10.1038/353844a0}, pmid = {1944558}, url = {https://doi.org/10.1038/353844a0} } @article{wendeln2018-29643512, author = {Wendeln, A. C. and Degenhardt, K. and Kaurani, L. and Gertig, M. and Ulas, T. and Jain, G. and Wagner, J. and Häsler, L. M. and others}, title = {{Innate immune memory in the brain shapes neurological disease hallmarks}}, journal = {Nature}, year = {2018}, doi = {10.1038/s41586-018-0023-4}, pmid = {29643512}, url = {https://doi.org/10.1038/s41586-018-0023-4} } @article{sorrentino2017-29211722, author = {Sorrentino, V. and Romani, M. and Mouchiroud, L. and Beck, J. S. and Zhang, H. and D'Amico, D. and Moullan, N. and Potenza, F. and others}, title = {{Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature25143}, pmid = {29211722}, url = {https://doi.org/10.1038/nature25143} } @article{ostendorf2022-36130725, author = {Ostendorf, Benjamin N and Patel, Mira A and Bilanovic, Jana and Hoffmann, H-Heinrich and Carrasco, Sebastian E and Rice, Charles M and Tavazoie, Sohail F}, title = {{Common human genetic variants of APOE impact murine COVID-19 mortality}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-05344-2}, pmid = {36130725}, url = {https://doi.org/10.1038/s41586-022-05344-2} } @article{ayata2025-1378ad15, author = {Ayata, P. and Crowley, J. M. and Challman, M. F. and Sahasrabuddhe, V. and Gratuze, M. and Werneburg, S. and others}, title = {{Lymphoid gene expression supports neuroprotective microglia function}}, journal = {Nature}, year = {2025} } @article{zhang2009-19641596, author = {Zhang, C. and Wu, B. and Beglopoulos, V. and Wines-Samuelson, M. and Zhang, D. and Dragatsis, I. and Südhof, T. C. and Shen, J.}, title = {{Presenilins are essential for regulating neurotransmitter release}}, journal = {Nature}, year = {2009}, doi = {10.1038/nature08177}, pmid = {19641596}, url = {https://doi.org/10.1038/nature08177} } @article{peretti2015-25607368, author = {Peretti, D. and Bastide, A. and Radford, H. and Verity, N. and Molloy, C. and Martin, M. G. and Moreno, J. A. and Steinert, JR. and others}, title = {{RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14142}, pmid = {25607368}, url = {https://doi.org/10.1038/nature14142} } @article{blanchard2022-36385529, author = {Blanchard, J. W. and Akay, L. A. and Davila-Velderrain, J. and von Maydell, D. and Mathys, H. and Davidson, S. M. and Effenberger, A. and Chen, C. Y. and others}, title = {{APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-05439-w}, pmid = {36385529}, url = {https://doi.org/10.1038/s41586-022-05439-w} } @article{yang2022-35165441, author = {Yang, A. C. and Vest, R. T. and Kern, F. and Lee, D. P. and Agam, M. and Maat, C. A. and Losada, P. M. and Chen, M. B. and others}, title = {{A human brain vascular atlas reveals diverse mediators of Alzheimer's risk}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-021-04369-3}, pmid = {35165441}, url = {https://doi.org/10.1038/s41586-021-04369-3} } @article{miller2022-35444284, author = {Miller, M. B. and Huang, A. Y. and Kim, J. and Zhou, Z. and Kirkham, S. L. and Maury, E. A. and Ziegenfuss, J. S. and Reed, H. C. and others}, title = {{Somatic genomic changes in single Alzheimer's disease neurons}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-04640-1}, pmid = {35444284}, url = {https://doi.org/10.1038/s41586-022-04640-1} } @article{demiguel2021-34880498, author = {De Miguel, Z. and Khoury, N. and Betley, M. J. and Lehallier, B. and Willoughby, D. and Olsson, N. and Yang, A. C. and Hahn, O. and others}, title = {{Exercise plasma boosts memory and dampens brain inflammation via clusterin}}, journal = {Nature}, year = {2021}, doi = {10.1038/s41586-021-04183-x}, pmid = {34880498}, url = {https://doi.org/10.1038/s41586-021-04183-x} } @article{drieu2022-36352225, author = {Drieu, A. and Du, S. and Storck, S. E. and Rustenhoven, J. and Papadopoulos, Z. and Dykstra, T. and Zhong, F. and Kim, K. and others}, title = {{Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-05397-3}, pmid = {36352225}, url = {https://doi.org/10.1038/s41586-022-05397-3} } @article{zhou2022-35794479, author = {Zhou, Y. and Su, Y. and Li, S. and Kennedy, B. C. and Zhang, D. Y. and Bond, A. M. and Sun, Y. and Jacob, F. and others}, title = {{Molecular landscapes of human hippocampal immature neurons across lifespan}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-04912-w}, pmid = {35794479}, url = {https://doi.org/10.1038/s41586-022-04912-w} } @article{chen2023-36890231, author = {Chen, X. and Firulyova, M. and Manis, M. and Herz, J. and Smirnov, I. and Aladyeva, E. and Wang, C. and Bao, X. and others}, title = {{Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy}}, journal = {Nature}, year = {2023}, doi = {10.1038/s41586-023-05788-0}, pmid = {36890231}, url = {https://doi.org/10.1038/s41586-023-05788-0} } @article{lauren2009-19242475, author = {Laurén, J. and Gimbel, D. A. and Nygaard, H. B. and Gilbert, J. W. and Strittmatter, S. M.}, title = {{Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers}}, journal = {Nature}, year = {2009}, doi = {10.1038/nature07761}, pmid = {19242475}, url = {https://doi.org/10.1038/nature07761} } @article{graff2012-22388814, author = {Gräff, J. and Rei, D. and Guan, J. S. and Wang, W. Y. and Seo, J. and Hennig, K. M. and Nieland, T. J. and Fass, D. M. and others}, title = {{An epigenetic blockade of cognitive functions in the neurodegenerating brain}}, journal = {Nature}, year = {2012}, doi = {10.1038/nature10849}, pmid = {22388814}, url = {https://doi.org/10.1038/nature10849} } @article{gjoneska2015-25693568, author = {Gjoneska, E. and Pfenning, A. R. and Mathys, H. and Quon, G. and Kundaje, A. and Tsai, L. H. and Kellis, M.}, title = {{Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14252}, pmid = {25693568}, url = {https://doi.org/10.1038/nature14252} } @article{roy2016-26982728, author = {Roy, D. S. and Arons, A. and Mitchell, T. I. and Pignatelli, M. and Ryan, T. J. and Tonegawa, S.}, title = {{Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease}}, journal = {Nature}, year = {2016}, doi = {10.1038/nature17172}, pmid = {26982728}, url = {https://doi.org/10.1038/nature17172} } @article{minhas2021-33473210, author = {Minhas, P. S. and Latif-Hernandez, A. and McReynolds, M. R. and Durairaj, A. S. and Wang, Q. and Rubin, A. and Joshi, A. U. and He, J. Q. and others}, title = {{Restoring metabolism of myeloid cells reverses cognitive decline in ageing}}, journal = {Nature}, year = {2021}, doi = {10.1038/s41586-020-03160-0}, pmid = {33473210}, url = {https://doi.org/10.1038/s41586-020-03160-0} } @article{samant2018-30429547, author = {Samant, Rahul S and Livingston, Christine M and Sontag, Emily M and Frydman, Judith}, title = {{Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control}}, journal = {Nature}, year = {2018}, doi = {10.1038/s41586-018-0678-x}, pmid = {30429547}, url = {https://doi.org/10.1038/s41586-018-0678-x} } @article{venegas2017-29293211, author = {Venegas, C. and Kumar, S. and Franklin, B. S. and Dierkes, T. and Brinkschulte, R. and Tejera, D. and Vieira-Saecker, A. and Schwartz, S. and others}, title = {{Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature25158}, pmid = {29293211}, url = {https://doi.org/10.1038/nature25158} } @article{song2018-29670280, author = {Song, X. and MØ, Jensen and Jogini, V. and Stein, R. A. and Lee, C. H. and Mchaourab, H. S. and Shaw, D. E. and Gouaux, E.}, title = {{Mechanism of NMDA receptor channel block by MK-801 and memantine}}, journal = {Nature}, year = {2018}, doi = {10.1038/s41586-018-0039-9}, pmid = {29670280}, url = {https://doi.org/10.1038/s41586-018-0039-9} } @article{schweighauser2020-32461689, author = {Schweighauser, M. and Shi, Y. and Tarutani, A. and Kametani, F. and Murzin, A. G. and Ghetti, B. and Matsubara, T. and Tomita, T. and others}, title = {{Structures of α-synuclein filaments from multiple system atrophy}}, journal = {Nature}, year = {2020}, doi = {10.1038/s41586-020-2317-6}, pmid = {32461689}, url = {https://doi.org/10.1038/s41586-020-2317-6} } @article{selkoe1999-10392577, author = {Selkoe, D. J.}, title = {{Translating cell biology into therapeutic advances in Alzheimer's disease}}, journal = {Nature}, year = {1999}, doi = {10.1038/399a023}, pmid = {10392577}, url = {https://doi.org/10.1038/399a023} } @article{choi2014-25307057, author = {Choi, S. H. and Kim, Y. H. and Hebisch, M. and Sliwinski, C. and Lee, S. and D'Avanzo, C. and Chen, H. and Hooli, B. and others}, title = {{A three-dimensional human neural cell culture model of Alzheimer's disease}}, journal = {Nature}, year = {2014}, doi = {10.1038/nature13800}, pmid = {25307057}, url = {https://doi.org/10.1038/nature13800} } @article{panin1997-9202123, author = {Panin, V. M. and Papayannopoulos, V. and Wilson, R. and Irvine, K. D.}, title = {{Fringe modulates Notch-ligand interactions}}, journal = {Nature}, year = {1997}, doi = {10.1038/43191}, pmid = {9202123}, url = {https://doi.org/10.1038/43191} } @article{seubert1992-1406936, author = {Seubert, P. and Vigo-Pelfrey, C. and Esch, F. and Lee, M. and Dovey, H. and Davis, D. and Sinha, S. and Schlossmacher, M. and others}, title = {{Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids}}, journal = {Nature}, year = {1992}, doi = {10.1038/359325a0}, pmid = {1406936}, url = {https://doi.org/10.1038/359325a0} } @article{seubert1993-7678698, author = {Seubert, P. and Oltersdorf, T. and Lee, M. G. and Barbour, R. and Blomquist, C. and Davis, D. L. and Bryant, K. and Fritz, L. C. and others}, title = {{Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide}}, journal = {Nature}, year = {1993}, doi = {10.1038/361260a0}, pmid = {7678698}, url = {https://doi.org/10.1038/361260a0} } @article{destrooper1999-10206645, author = {De Strooper, B. and Annaert, W. and Cupers, P. and Saftig, P. and Craessaerts, K. and Mumm, J. S. and Schroeter, E. H. and Schrijvers, V. and others}, title = {{A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain}}, journal = {Nature}, year = {1999}, doi = {10.1038/19083}, pmid = {10206645}, url = {https://doi.org/10.1038/19083} } @article{destrooper1998-9450754, author = {De Strooper, B. and Saftig, P. and Craessaerts, K. and Vanderstichele, H. and Guhde, G. and Annaert, W. and Von Figura, K. and Van Leuven, F.}, title = {{Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein}}, journal = {Nature}, year = {1998}, doi = {10.1038/34910}, pmid = {9450754}, url = {https://doi.org/10.1038/34910} } @article{janus2000-11140685, author = {Janus, C. and Pearson, J. and McLaurin, J. and Mathews, P. M. and Jiang, Y. and Schmidt, S. D. and Chishti, M. A. and Horne, P. and others}, title = {{A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease}}, journal = {Nature}, year = {2000}, doi = {10.1038/35050110}, pmid = {11140685}, url = {https://doi.org/10.1038/35050110} } @article{duff1996-8878479, author = {Duff, K. and Eckman, C. and Zehr, C. and Yu, X. and Prada, C. M. and Perez-tur, J. and Hutton, M. and Buee, L. and others}, title = {{Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1}}, journal = {Nature}, year = {1996}, doi = {10.1038/383710a0}, pmid = {8878479}, url = {https://doi.org/10.1038/383710a0} } @article{phiel2003-12761548, author = {Phiel, C. J. and Wilson, C. A. and Lee, V. M. and Klein, P. S.}, title = {{GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides}}, journal = {Nature}, year = {2003}, doi = {10.1038/nature01640}, pmid = {12761548}, url = {https://doi.org/10.1038/nature01640} } @article{paquet2016-27120160, author = {Paquet, D. and Kwart, D. and Chen, A. and Sproul, A. and Jacob, S. and Teo, S. and Olsen, K. M. and Gregg, A. and others}, title = {{Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9}}, journal = {Nature}, year = {2016}, doi = {10.1038/nature17664}, pmid = {27120160}, url = {https://doi.org/10.1038/nature17664} } @article{li2000-10864326, author = {Li, Y. M. and Xu, M. and Lai, M. T. and Huang, Q. and Castro, J. L. and DiMuzio-Mower, J. and Harrison, T. and Lellis, C. and others}, title = {{Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1}}, journal = {Nature}, year = {2000}, doi = {10.1038/35015085}, pmid = {10864326}, url = {https://doi.org/10.1038/35015085} } @article{takasugi2003-12660785, author = {Takasugi, N. and Tomita, T. and Hayashi, I. and Tsuruoka, M. and Niimura, M. and Takahashi, Y. and Thinakaran, G. and Iwatsubo, T.}, title = {{The role of presenilin cofactors in the gamma-secretase complex}}, journal = {Nature}, year = {2003}, doi = {10.1038/nature01506}, pmid = {12660785}, url = {https://doi.org/10.1038/nature01506} } @article{haass1992-1608449, author = {Haass, C. and Koo, E. H. and Mellon, A. and Hung, A. Y. and Selkoe, D. J.}, title = {{Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments}}, journal = {Nature}, year = {1992}, doi = {10.1038/357500a0}, pmid = {1608449}, url = {https://doi.org/10.1038/357500a0} } @article{struhl1999-10206646, author = {Struhl, G. and Greenwald, I.}, title = {{Presenilin is required for activity and nuclear access of Notch in Drosophila}}, journal = {Nature}, year = {1999}, doi = {10.1038/19091}, pmid = {10206646}, url = {https://doi.org/10.1038/19091} } @article{wong1997-9153393, author = {Wong, P. C. and Zheng, H. and Chen, H. and Becher, M. W. and Sirinathsinghji, D. J. and Trumbauer, M. E. and Chen, H. Y. and Price, D. L. and others}, title = {{Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm}}, journal = {Nature}, year = {1997}, doi = {10.1038/387288a0}, pmid = {9153393}, url = {https://doi.org/10.1038/387288a0} } @article{fischer2007-17468743, author = {Fischer, A. and Sananbenesi, F. and Wang, X. and Dobbin, M. and Tsai, L. H.}, title = {{Recovery of learning and memory is associated with chromatin remodelling}}, journal = {Nature}, year = {2007}, doi = {10.1038/nature05772}, pmid = {17468743}, url = {https://doi.org/10.1038/nature05772} } @article{hellstrom2007-17259973, author = {Hellström, M. and Phng, L. K. and Hofmann, J. J. and Wallgard, E. and Coultas, L. and Lindblom, P. and Alva, J. and Nilsson, A. K. and others}, title = {{Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis}}, journal = {Nature}, year = {2007}, doi = {10.1038/nature05571}, pmid = {17259973}, url = {https://doi.org/10.1038/nature05571} } @article{smeyne1993-8483500, author = {Smeyne, R. J. and Vendrell, M. and Hayward, M. and Baker, S. J. and Miao, G. G. and Schilling, K. and Robertson, L. M. and Curran, T. and others}, title = {{Continuous c-fos expression precedes programmed cell death in vivo}}, journal = {Nature}, year = {1993}, doi = {10.1038/363166a0}, pmid = {8483500}, url = {https://doi.org/10.1038/363166a0} } @article{levitan1995-7566091, author = {Levitan, D. and Greenwald, I.}, title = {{Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene}}, journal = {Nature}, year = {1995}, doi = {10.1038/377351a0}, pmid = {7566091}, url = {https://doi.org/10.1038/377351a0} } @article{wright2005-16341018, author = {Wright, C. F. and Teichmann, S. A. and Clarke, J. and Dobson, C. M.}, title = {{The importance of sequence diversity in the aggregation and evolution of proteins}}, journal = {Nature}, year = {2005}, doi = {10.1038/nature04195}, pmid = {16341018}, url = {https://doi.org/10.1038/nature04195} } @article{taguchi2000-10830965, author = {Taguchi, A. and Blood, D. C. and del Toro, G. and Canet, A. and Lee, D. C. and Qu, W. and Tanji, N. and Lu, Y. and others}, title = {{Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases}}, journal = {Nature}, year = {2000}, doi = {10.1038/35012626}, pmid = {10830965}, url = {https://doi.org/10.1038/35012626} } @article{lorenzo1994-8152488, author = {Lorenzo, A. and Razzaboni, B. and Weir, G. C. and Yankner, B. A.}, title = {{Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus}}, journal = {Nature}, year = {1994}, doi = {10.1038/368756a0}, pmid = {8152488}, url = {https://doi.org/10.1038/368756a0} } @article{gray1996-8878480, author = {Gray, R. and Rajan, A. S. and Radcliffe, K. A. and Yakehiro, M. and Dani, J. A.}, title = {{Hippocampal synaptic transmission enhanced by low concentrations of nicotine}}, journal = {Nature}, year = {1996}, doi = {10.1038/383713a0}, pmid = {8878480}, url = {https://doi.org/10.1038/383713a0} } @article{iaccarino2016-27929004, author = {Iaccarino, H. F. and Singer, A. C. and Martorell, A. J. and Rudenko, A. and Gao, F. and Gillingham, T. Z. and Mathys, H. and Seo, J. and others}, title = {{Gamma frequency entrainment attenuates amyloid load and modifies microglia}}, journal = {Nature}, year = {2016}, doi = {10.1038/nature20587}, pmid = {27929004}, url = {https://doi.org/10.1038/nature20587} } @article{meda1995-7715705, author = {Meda, L. and Cassatella, M. A. and Szendrei, G. I. and Otvos, L. and Baron, P. and Villalba, M. and Ferrari, D. and Rossi, F.}, title = {{Activation of microglial cells by beta-amyloid protein and interferon-gamma}}, journal = {Nature}, year = {1995}, doi = {10.1038/374647a0}, pmid = {7715705}, url = {https://doi.org/10.1038/374647a0} } @article{vanes2005-15959515, author = {van Es, J. H. and van Gijn, M. E. and Riccio, O. and van den Born, M. and Vooijs, M. and Begthel, H. and Cozijnsen, M. and Robine, S. and others}, title = {{Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells}}, journal = {Nature}, year = {2005}, doi = {10.1038/nature03659}, pmid = {15959515}, url = {https://doi.org/10.1038/nature03659} } @article{brenneman1988-2845276, author = {Brenneman, D. E. and Westbrook, G. L. and Fitzgerald, S. P. and Ennist, D. L. and Elkins, K. L. and Ruff, M. R. and Pert, C. B.}, title = {{Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide}}, journal = {Nature}, year = {1988}, doi = {10.1038/335639a0}, pmid = {2845276}, url = {https://doi.org/10.1038/335639a0} } @article{peelaerts2015-26061766, author = {Peelaerts, W. and Bousset, L. and Van der Perren, A. and Moskalyuk, A. and Pulizzi, R. and Giugliano, M. and Van den Haute, C. and Melki, R. and others}, title = {{α-Synuclein strains cause distinct synucleinopathies after local and systemic administration}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14547}, pmid = {26061766}, url = {https://doi.org/10.1038/nature14547} } @article{sawaya2007-17468747, author = {Sawaya, M. R. and Sambashivan, S. and Nelson, R. and Ivanova, M. I. and Sievers, S. A. and Apostol, M. I. and Thompson, M. J. and Balbirnie, M. and others}, title = {{Atomic structures of amyloid cross-beta spines reveal varied steric zippers}}, journal = {Nature}, year = {2007}, doi = {10.1038/nature05695}, pmid = {17468747}, url = {https://doi.org/10.1038/nature05695} } @article{lashuel2002-12124613, author = {Lashuel, H. A. and Hartley, D. and Petre, B. M. and Walz, T. and Lansbury, P. T.}, title = {{Neurodegenerative disease: amyloid pores from pathogenic mutations}}, journal = {Nature}, year = {2002}, doi = {10.1038/418291a}, pmid = {12124613}, url = {https://doi.org/10.1038/418291a} } @article{goedert1996-8849730, author = {Goedert, M. and Jakes, R. and Spillantini, M. G. and Hasegawa, M. and Smith, M. J. and Crowther, R. A.}, title = {{Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans}}, journal = {Nature}, year = {1996}, doi = {10.1038/383550a0}, pmid = {8849730}, url = {https://doi.org/10.1038/383550a0} } @article{davies1980-6107862, author = {Davies, P. and Katzman, R. and Terry, R. D.}, title = {{Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa}}, journal = {Nature}, year = {1980}, doi = {10.1038/288279a0}, pmid = {6107862}, url = {https://doi.org/10.1038/288279a0} } @article{lu2004-15190254, author = {Lu, T. and Pan, Y. and Kao, S. Y. and Li, C. and Kohane, I. and Chan, J. and Yankner, B. A.}, title = {{Gene regulation and DNA damage in the ageing human brain}}, journal = {Nature}, year = {2004}, doi = {10.1038/nature02661}, pmid = {15190254}, url = {https://doi.org/10.1038/nature02661} } @article{huerta1993-8355787, author = {Huerta, P. T. and Lisman, J. E.}, title = {{Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced rhythmic state}}, journal = {Nature}, year = {1993}, doi = {10.1038/364723a0}, pmid = {8355787}, url = {https://doi.org/10.1038/364723a0} } @article{hartl2011-21776078, author = {Hartl, F. U. and Bracher, A. and Hayer-Hartl, M.}, title = {{Molecular chaperones in protein folding and proteostasis}}, journal = {Nature}, year = {2011}, doi = {10.1038/nature10317}, pmid = {21776078}, url = {https://doi.org/10.1038/nature10317} } @article{uehara2006-16724068, author = {Uehara, T. and Nakamura, T. and Yao, D. and Shi, Z. Q. and Gu, Z. and Ma, Y. and Masliah, E. and Nomura, Y. and others}, title = {{S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration}}, journal = {Nature}, year = {2006}, doi = {10.1038/nature04782}, pmid = {16724068}, url = {https://doi.org/10.1038/nature04782} } @article{saleh2004-15129283, author = {Saleh, M. and Vaillancourt, J. P. and Graham, R. K. and Huyck, M. and Srinivasula, S. M. and Alnemri, E. S. and Steinberg, M. H. and Nolan, V. and others}, title = {{Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms}}, journal = {Nature}, year = {2004}, doi = {10.1038/nature02451}, pmid = {15129283}, url = {https://doi.org/10.1038/nature02451} } @article{busciglio1995-8524410, author = {Busciglio, J. and Yankner, B. A.}, title = {{Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro}}, journal = {Nature}, year = {1995}, doi = {10.1038/378776a0}, pmid = {8524410}, url = {https://doi.org/10.1038/378776a0} } @article{joachim1989-2528696, author = {Joachim, C. L. and Mori, H. and Selkoe, D. J.}, title = {{Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease}}, journal = {Nature}, year = {1989}, doi = {10.1038/341226a0}, pmid = {2528696}, url = {https://doi.org/10.1038/341226a0} } @article{tanzi1987-2888020, author = {Tanzi, R. E. and St George-Hyslop, P. H. and Haines, J. L. and Polinsky, R. J. and Nee, L. and Foncin, J. F. and Neve, R. L. and McClatchey, A. I. and others}, title = {{The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene}}, journal = {Nature}, year = {1987}, doi = {10.1038/329156a0}, pmid = {2888020}, url = {https://doi.org/10.1038/329156a0} } @article{bishop2010-20336135, author = {Bishop, N. A. and Lu, T. and Yankner, B. A.}, title = {{Neural mechanisms of ageing and cognitive decline}}, journal = {Nature}, year = {2010}, doi = {10.1038/nature08983}, pmid = {20336135}, url = {https://doi.org/10.1038/nature08983} } @article{lesne2024-6acae23c, author = {Lesné, S. and Koh, M. T. and Kotilinek, L. and Kayed, R. and Glabe, C. G. and Yang, A. and Gallagher, M. and Ashe, K. H.}, title = {{Retraction Note: A specific amyloid-beta protein assembly in the brain impairs memory}}, journal = {Nature}, year = {2024} } @article{nikolaev2009-19225519, author = {Nikolaev, A. and McLaughlin, T. and O'Leary, D. D. and Tessier-Lavigne, M.}, title = {{APP binds DR6 to trigger axon pruning and neuron death via distinct caspases}}, journal = {Nature}, year = {2009}, doi = {10.1038/nature07767}, pmid = {19225519}, url = {https://doi.org/10.1038/nature07767} } @article{lesne2006-16541076, author = {Lesné, S. and Koh, M. T. and Kotilinek, L. and Kayed, R. and Glabe, C. G. and Yang, A. and Gallagher, M. and Ashe, K. H.}, title = {{A specific amyloid-beta protein assembly in the brain impairs memory}}, journal = {Nature}, year = {2006}, doi = {10.1038/nature04533}, pmid = {16541076}, url = {https://doi.org/10.1038/nature04533} } @article{rhinn2013-23883936, author = {Rhinn, Herve and Fujita, Ryousuke and Qiang, Liang and Cheng, Rong and Lee, Joseph H and Abeliovich, Asa}, title = {{Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease}}, journal = {Nature}, year = {2013}, doi = {10.1038/nature12415}, pmid = {23883936}, url = {https://doi.org/10.1038/nature12415} }