% alzhub.org library filter
% Source: https://alzhub.org/research?institution=I4210136897
% 241 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{fang2025-39806070,
  author  = {Fang, M. and Hu, J. and Weiss, J. and Knopman, D. S. and Albert, M. and Windham, B. G. and Walker, K. A. and Sharrett, A. R. and Gottesman, R. F. and Lutsey, P. L. and others},
  title   = {{Lifetime risk and projected burden of dementia}},
  journal = {Nature Medicine},
  year    = {2025},
  doi     = {10.1038/s41591-024-03340-9},
  pmid    = {39806070},
  url     = {https://doi.org/10.1038/s41591-024-03340-9}
}

@article{kunkle2019-30820047,
  author  = {Kunkle, B. W. and Grenier-Boley, B. and Sims, R. and Bis, J. C. and Damotte, V. and Naj, A. C. and Boland, A. and Vronskaya, M. and others},
  title   = {{Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing}},
  journal = {Nature genetics},
  year    = {2019},
  doi     = {10.1038/s41588-019-0358-2},
  pmid    = {30820047},
  url     = {https://doi.org/10.1038/s41588-019-0358-2}
}

@article{sims2017-28714976,
  author  = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others},
  title   = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2017},
  doi     = {10.1038/ng.3916},
  pmid    = {28714976},
  url     = {https://doi.org/10.1038/ng.3916}
}

@article{mcneil2018-30221597,
  author  = {McNeil, J. J. and Wolfe, R. and Woods, R. L. and Tonkin, A. M. and Donnan, G. A. and Nelson, M. R. and Reid, C. M. and Lockery, J. E. and others},
  title   = {{Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly}},
  journal = {The New England journal of medicine},
  year    = {2018},
  doi     = {10.1056/nejmoa1805819},
  pmid    = {30221597},
  url     = {https://doi.org/10.1056/nejmoa1805819}
}

@article{lu2024-39068543,
  author  = {Lu, Y. and Pike, JR. and Chen, J. and Walker, K. A. and Sullivan, K. J. and Thyagarajan, B. and Mielke, M. M. and Lutsey, P. L. and Knopman, D. and Gottesman, R. F. and Sharrett, A. R. and Coresh, J. and others},
  title   = {{Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia}},
  journal = {JAMA},
  year    = {2024},
  doi     = {10.1001/jama.2024.6619},
  pmid    = {39068543},
  url     = {https://doi.org/10.1001/jama.2024.6619}
}

@article{jun2016-25778476,
  author  = {Jun, G. and Ibrahim-Verbaas, C. A. and Vronskaya, M. and Lambert, J. C. and Chung, J. and Naj, A. C. and Kunkle, B. W. and Wang, L. S. and others},
  title   = {{A novel Alzheimer disease locus located near the gene encoding tau protein}},
  journal = {Molecular psychiatry},
  year    = {2016},
  doi     = {10.1038/mp.2015.23},
  pmid    = {25778476},
  url     = {https://doi.org/10.1038/mp.2015.23}
}

@article{rensma2018-29656031,
  author  = {Rensma, S. P. and van Sloten, T. T. and Launer, L. J. and Stehouwer, C. D. A.},
  title   = {{Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2018},
  doi     = {10.1016/j.neubiorev.2018.04.003},
  pmid    = {29656031},
  url     = {https://doi.org/10.1016/j.neubiorev.2018.04.003}
}

@article{ferrari2014-24943344,
  author  = {Ferrari, R. and Hernandez, D. G. and Nalls, M. A. and Rohrer, J. D. and Ramasamy, A. and Kwok, J. B. and Dobson-Stone, C. and Brooks, W. S. and others},
  title   = {{Frontotemporal dementia and its subtypes: a genome-wide association study}},
  journal = {The Lancet. Neurology},
  year    = {2014},
  doi     = {10.1016/s1474-4422(14)70065-1},
  pmid    = {24943344},
  url     = {https://doi.org/10.1016/s1474-4422(14)70065-1}
}

@article{study2019-30688979,
  author  = {{SPRINT MIND Investigators for the SPRINT Research Group} and Williamson, J. D. and Pajewski, N. M. and Auchus, A. P. and Bryan, R. N. and Chelune, G. and Cheung, A. K. and Cleveland, M. L. and others},
  title   = {{Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial}},
  journal = {JAMA},
  year    = {2019},
  doi     = {10.1001/jama.2018.21442},
  pmid    = {30688979},
  url     = {https://doi.org/10.1001/jama.2018.21442}
}

@article{oh2025-40164724,
  author  = {Oh, H. S. and Urey, D. Y. and Karlsson, L. and Zhu, Z. and Shen, Y. and Farinas, A. and Timsina, J. and Duggan, M. R. and others},
  title   = {{A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03565-2},
  pmid    = {40164724},
  url     = {https://doi.org/10.1038/s41591-025-03565-2}
}

@article{ding2020-31706889,
  author  = {Ding, J. and Davis-Plourde, K. L. and Sedaghat, S. and Tully, P. J. and Wang, W. and Phillips, C. and Pase, M. P. and Himali, J. J. and others},
  title   = {{Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies}},
  journal = {The Lancet. Neurology},
  year    = {2020},
  doi     = {10.1016/s1474-4422(19)30393-x},
  pmid    = {31706889},
  url     = {https://doi.org/10.1016/s1474-4422(19)30393-x}
}

@article{intveld2001-11794217,
  author  = {in t' Veld, B. A. and Ruitenberg, A. and Hofman, A. and Launer, L. J. and van Duijn, C. M. and Stijnen, T. and Breteler, M. M. and Stricker, B. H.},
  title   = {{Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2001},
  doi     = {10.1056/nejmoa010178},
  pmid    = {11794217},
  url     = {https://doi.org/10.1056/nejmoa010178}
}

@article{beydoun2014-24962204,
  author  = {Beydoun, M. A. and Beydoun, H. A. and Gamaldo, A. A. and Teel, A. and Zonderman, A. B. and Wang, Y.},
  title   = {{Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis}},
  journal = {BMC public health},
  year    = {2014},
  doi     = {10.1186/1471-2458-14-643},
  pmid    = {24962204},
  url     = {https://doi.org/10.1186/1471-2458-14-643}
}

@article{chew2015-26305649,
  author  = {Chew, E. Y. and Clemons, T. E. and Agrón, E. and Launer, L. J. and Grodstein, F. and Bernstein, P. S.},
  title   = {{Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial}},
  journal = {JAMA},
  year    = {2015},
  doi     = {10.1001/jama.2015.9677},
  pmid    = {26305649},
  url     = {https://doi.org/10.1001/jama.2015.9677}
}

@article{besser2018-30376508,
  author  = {Besser, L. and Kukull, W. and Knopman, D. S. and Chui, H. and Galasko, D. and Weintraub, S. and Jicha, G. and Carlsson, C. and others},
  title   = {{Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2018},
  doi     = {10.1097/wad.0000000000000279},
  pmid    = {30376508},
  url     = {https://doi.org/10.1097/wad.0000000000000279}
}

@article{varma2018-29370177,
  author  = {Varma, V. R. and Oommen, A. M. and Varma, S. and Casanova, R. and An, Y. and Andrews, R. M. and O'Brien, R. and Pletnikova, O. and others},
  title   = {{Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study}},
  journal = {PLoS medicine},
  year    = {2018},
  doi     = {10.1371/journal.pmed.1002482},
  pmid    = {29370177},
  url     = {https://doi.org/10.1371/journal.pmed.1002482}
}

@article{li2026-41559019,
  author  = {Li, Joanne M. and Gauen, Abigail and Zmora, Rachel and Stephen, John J. and Petito, Lucia C. and Scholtens, Denise and Peterson, Elizabeth and Kohli-Lynch, Ciaran Navin and others},
  title   = {{Midlife and late‐life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71065},
  pmid    = {41559019},
  url     = {https://doi.org/10.1002/alz.71065}
}

@article{kawas2000-10851365,
  author  = {Kawas, C. and Gray, S. and Brookmeyer, R. and Fozard, J. and Zonderman, A.},
  title   = {{Age-specific incidence rates of Alzheimer's disease: the Baltimore Longitudinal Study of Aging}},
  journal = {Neurology},
  year    = {2000},
  doi     = {10.1212/wnl.54.11.2072},
  pmid    = {10851365},
  url     = {https://doi.org/10.1212/wnl.54.11.2072}
}

@article{cukiermanyaffe2009-19171735,
  author  = {Cukierman-Yaffe, T. and Gerstein, H. C. and Williamson, J. D. and Lazar, R. M. and Lovato, L. and Miller, M. E. and Coker, L. H. and Murray, A. and others},
  title   = {{Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial}},
  journal = {Diabetes care},
  year    = {2009},
  doi     = {10.2337/dc08-1153},
  pmid    = {19171735},
  url     = {https://doi.org/10.2337/dc08-1153}
}

@article{albanese2017-28761927,
  author  = {Albanese, E. and Launer, L. J. and Egger, M. and Prince, M. J. and Giannakopoulos, P. and Wolters, F. J. and Egan, K.},
  title   = {{Body mass index in midlife and dementia: Systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2017},
  doi     = {10.1016/j.dadm.2017.05.007},
  pmid    = {28761927},
  url     = {https://doi.org/10.1016/j.dadm.2017.05.007}
}

@article{raghavan2020-32568366,
  author  = {Raghavan, N. S. and Dumitrescu, L. and Mormino, E. and Mahoney, E. R. and Lee, A. J. and Gao, Y. and Bilgel, M. and Goldstein, D. and others},
  title   = {{Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.1760},
  pmid    = {32568366},
  url     = {https://doi.org/10.1001/jamaneurol.2020.1760}
}

@article{hohman2018-29801024,
  author  = {Hohman, T. J. and Dumitrescu, L. and Barnes, L. L. and Thambisetty, M. and Beecham, G. and Kunkle, B. and Gifford, K. A. and Bush, W. S. and others},
  title   = {{Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2018.0821},
  pmid    = {29801024},
  url     = {https://doi.org/10.1001/jamaneurol.2018.0821}
}

@article{nasrallah2021-33683313,
  author  = {Nasrallah, I. M. and Gaussoin, S. A. and Pomponio, R. and Dolui, S. and Erus, G. and Wright, C. B. and Launer, L. J. and Detre, J. A. and others},
  title   = {{Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial}},
  journal = {JAMA neurology},
  year    = {2021},
  doi     = {10.1001/jamaneurol.2021.0178},
  pmid    = {33683313},
  url     = {https://doi.org/10.1001/jamaneurol.2021.0178}
}

@article{lin2011-21320988,
  author  = {Lin, F. R. and Metter, E. J. and O'Brien, R. J. and Resnick, S. M. and Zonderman, A. B. and Ferrucci, L.},
  title   = {{Hearing loss and incident dementia}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.362},
  pmid    = {21320988},
  url     = {https://doi.org/10.1001/archneurol.2010.362}
}

@article{nalls2013-23588557,
  author  = {Nalls, M. A. and Duran, R. and Lopez, G. and Kurzawa-Akanbi, M. and McKeith, I. G. and Chinnery, P. F. and Morris, C. M. and Theuns, J. and others},
  title   = {{A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.1925},
  pmid    = {23588557},
  url     = {https://doi.org/10.1001/jamaneurol.2013.1925}
}

@article{ashton2021-34099648,
  author  = {Ashton, N. J. and Janelidze, S. and Al Khleifat, A. and Leuzy, A. and van der Ende, E. L. and Karikari, T. K. and Benedet, A. L. and Pascoal, T. A. and others},
  title   = {{A multicentre validation study of the diagnostic value of plasma neurofilament light}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-23620-z},
  pmid    = {34099648},
  url     = {https://doi.org/10.1038/s41467-021-23620-z}
}

@article{armstrong2020-32517579,
  author  = {Armstrong, N. J. and Mather, K. A. and Sargurupremraj, M. and Knol, M. J. and Malik, R. and Satizabal, C. L. and Yanek, L. R. and Wen, W. and others},
  title   = {{Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities}},
  journal = {Stroke},
  year    = {2020},
  doi     = {10.1161/strokeaha.119.027544},
  pmid    = {32517579},
  url     = {https://doi.org/10.1161/strokeaha.119.027544}
}

@article{wolters2019-31356640,
  author  = {Wolters, F. J. and Yang, Q. and Biggs, M. L. and Jakobsdottir, J. and Li, S. and Evans, D. S. and Bis, J. C. and Harris, T. B. and others},
  title   = {{The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)}},
  journal = {PloS one},
  year    = {2019},
  doi     = {10.1371/journal.pone.0219668},
  pmid    = {31356640},
  url     = {https://doi.org/10.1371/journal.pone.0219668}
}

@article{sperling2011-21514248,
  author  = {Sperling, R. A. and Aisen, P. S. and Beckett, L. A. and Bennett, D. A. and Craft, S. and Fagan, A. M. and Iwatsubo, T. and Jack, C. R. and others},
  title   = {{Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2011},
  doi     = {10.1016/j.jalz.2011.03.003},
  pmid    = {21514248},
  url     = {https://doi.org/10.1016/j.jalz.2011.03.003}
}

@article{younan2020-31746986,
  author  = {Younan, D. and Petkus, A. J. and Widaman, K. F. and Wang, X. and Casanova, R. and Espeland, M. A. and Gatz, M. and Henderson, V. W. and others},
  title   = {{Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awz348},
  pmid    = {31746986},
  url     = {https://doi.org/10.1093/brain/awz348}
}

@article{dotson2010-20603482,
  author  = {Dotson, V. M. and Beydoun, M. A. and Zonderman, A. B.},
  title   = {{Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181e62124},
  pmid    = {20603482},
  url     = {https://doi.org/10.1212/wnl.0b013e3181e62124}
}

@article{driscoll2009-19487648,
  author  = {Driscoll, I. and Davatzikos, C. and An, Y. and Wu, X. and Shen, D. and Kraut, M. and Resnick, S. M.},
  title   = {{Longitudinal pattern of regional brain volume change differentiates normal aging from MCI}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181a82634},
  pmid    = {19487648},
  url     = {https://doi.org/10.1212/wnl.0b013e3181a82634}
}

@article{peter2025-40513084,
  author  = {Peter, Christopher and Sathe, Aditi and Shashikumar, Niranjana and Pechman, Kimberly R. and Workmeister, Abigail W. and Jackson, Trevor Bryan and Huo, Yuankai and Mukherjee, Shubhabrata and others},
  title   = {{White Matter Abnormalities and Cognition in Aging and Alzheimer Disease}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.1601},
  pmid    = {40513084},
  url     = {https://doi.org/10.1001/jamaneurol.2025.1601}
}

@article{shadyab2026-41805953,
  author  = {Shadyab, A. H. and Zhang, B. and LaCroix, A. Z. and Mielke, M. M. and Resnick, S. M. and Nguyen, S. and Ferrucci, L. and Libermann, T. A. and Ngo, L. and Casanova, R. and others},
  title   = {{Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women}},
  journal = {JAMA Network Open},
  year    = {2026},
  doi     = {10.1001/jamanetworkopen.2026.1295},
  pmid    = {41805953},
  url     = {https://doi.org/10.1001/jamanetworkopen.2026.1295}
}

@article{chauhan2015-25670335,
  author  = {Chauhan, G. and Adams, H. H. H. and Bis, J. C. and Weinstein, G. and Yu, L. and Töglhofer, A. M. and Smith, A. V. and van der Lee, S. J. and others},
  title   = {{Association of Alzheimer's disease GWAS loci with MRI markers of brain aging}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2014.12.028},
  pmid    = {25670335},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.12.028}
}

@article{williamson2007-17599421,
  author  = {Williamson, J. D. and Miller, M. E. and Bryan, R. N. and Lazar, R. M. and Coker, L. H. and Johnson, J. and Cukierman, T. and Horowitz, K. R. and others},
  title   = {{The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods}},
  journal = {The American journal of cardiology},
  year    = {2007},
  doi     = {10.1016/j.amjcard.2007.03.029},
  pmid    = {17599421},
  url     = {https://doi.org/10.1016/j.amjcard.2007.03.029}
}

@article{kaup2016-26982217,
  author  = {Kaup, A. R. and Byers, A. L. and Falvey, C. and Simonsick, E. M. and Satterfield, S. and Ayonayon, H. N. and Smagula, S. F. and Rubin, S. M. and others},
  title   = {{Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia}},
  journal = {JAMA psychiatry},
  year    = {2016},
  doi     = {10.1001/jamapsychiatry.2016.0004},
  pmid    = {26982217},
  url     = {https://doi.org/10.1001/jamapsychiatry.2016.0004}
}

@article{benitez2014-24439484,
  author  = {Benitez, B. A. and Jin, S. C. and Guerreiro, R. and Graham, R. and Lord, J. and Harold, D. and Sims, R. and Lambert, J. C. and others},
  title   = {{Missense variant in TREML2 protects against Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.12.010},
  pmid    = {24439484},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.12.010}
}

@article{yaffe2013-24355614,
  author  = {Yaffe, K. and Falvey, C. and Harris, T. B. and Newman, A. and Satterfield, S. and Koster, A. and Ayonayon, H. and Simonsick, E. and others},
  title   = {{Effect of socioeconomic disparities on incidence of dementia among biracial older adults: prospective study}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2013},
  doi     = {10.1136/bmj.f7051},
  pmid    = {24355614},
  url     = {https://doi.org/10.1136/bmj.f7051}
}

@article{waldstein2008-18025297,
  author  = {Waldstein, SR. and Rice, S. C. and Thayer, J. F. and Najjar, S. S. and Scuteri, A. and Zonderman, A. B.},
  title   = {{Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging}},
  journal = {Hypertension (Dallas, Tex. : 1979)},
  year    = {2008},
  doi     = {10.1161/hypertensionaha.107.093674},
  pmid    = {18025297},
  url     = {https://doi.org/10.1161/hypertensionaha.107.093674}
}

@article{harvie2011-20921964,
  author  = {Harvie, M. N. and Pegington, M. and Mattson, M. P. and Frystyk, J. and Dillon, B. and Evans, G. and Cuzick, J. and Jebb, S. A. and others},
  title   = {{The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women}},
  journal = {International journal of obesity (2005)},
  year    = {2011},
  doi     = {10.1038/ijo.2010.171},
  pmid    = {20921964},
  url     = {https://doi.org/10.1038/ijo.2010.171}
}

@article{ayton2015-25988319,
  author  = {Ayton, S. and Faux, N. G. and Bush, A. I. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE}},
  journal = {Nature communications},
  year    = {2015},
  doi     = {10.1038/ncomms7760},
  pmid    = {25988319},
  url     = {https://doi.org/10.1038/ncomms7760}
}

@article{chouraki2015-25217292,
  author  = {Chouraki, V. and Beiser, A. and Younkin, L. and Preis, SR. and Weinstein, G. and Hansson, O. and Skoog, I. and Lambert, J. C. and others},
  title   = {{Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.07.001},
  pmid    = {25217292},
  url     = {https://doi.org/10.1016/j.jalz.2014.07.001}
}

@article{sipila2026-41969011,
  author  = {Sipilä, Pyry N and Pentti, Jaana and Frank, Philipp and Duggan, Michael R and Walker, Keenan A and Strandberg, Timo E and Lindbohm, Joni V and Kivimäki, Mika},
  title   = {{The role of frailty and comorbidities in severe infections and the risk of dementia: a prospective, multicohort, observational study}},
  journal = {The lancet. Healthy longevity},
  year    = {2026},
  doi     = {10.1016/j.lanhl.2026.100826},
  pmid    = {41969011},
  url     = {https://doi.org/10.1016/j.lanhl.2026.100826}
}

@article{delgadoperaza2023-37730689,
  author  = {Delgado-Peraza, F. and Nogueras-Ortiz, C. and Simonsen, A. H. and Knight, D. D. and Yao, P. J. and Goetzl, E. J. and Jensen, C. S. and Høgh, P. and others},
  title   = {{Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2023},
  doi     = {10.1186/s13195-023-01303-9},
  pmid    = {37730689},
  url     = {https://doi.org/10.1186/s13195-023-01303-9}
}

@article{betthauser2022-35856240,
  author  = {Betthauser, T. J. and Bilgel, M. and Koscik, R. L. and Jedynak, B. M. and An, Y. and Kellett, K. A. and Moghekar, A. and Jonaitis, E. M. and others},
  title   = {{Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awac213},
  pmid    = {35856240},
  url     = {https://doi.org/10.1093/brain/awac213}
}

@article{kapogiannis2015-25342129,
  author  = {Kapogiannis, D. and Boxer, A. and Schwartz, J. B. and Abner, E. L. and Biragyn, A. and Masharani, U. and Frassetto, L. and Petersen, R. C. and others},
  title   = {{Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2015},
  doi     = {10.1096/fj.14-262048},
  pmid    = {25342129},
  url     = {https://doi.org/10.1096/fj.14-262048}
}

@article{armstrong2019-31268512,
  author  = {Armstrong, N. M. and An, Y. and Doshi, J. and Erus, G. and Ferrucci, L. and Davatzikos, C. and Deal, J. A. and Lin, F. R. and others},
  title   = {{Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss}},
  journal = {JAMA otolaryngology-- head \& neck surgery},
  year    = {2019},
  doi     = {10.1001/jamaoto.2019.1610},
  pmid    = {31268512},
  url     = {https://doi.org/10.1001/jamaoto.2019.1610}
}

@article{varma2021-34043628,
  author  = {Varma, V. R. and Wang, Y. and An, Y. and Varma, S. and Bilgel, M. and Doshi, J. and Legido-Quigley, C. and Delgado, J. C. and others},
  title   = {{Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study}},
  journal = {PLoS medicine},
  year    = {2021},
  doi     = {10.1371/journal.pmed.1003615},
  pmid    = {34043628},
  url     = {https://doi.org/10.1371/journal.pmed.1003615}
}

@article{majounie2012-22406228,
  author  = {Majounie, E. and Renton, A. E. and Mok, K. and Dopper, E. G. and Waite, A. and Rollinson, S. and Chiò, A. and Restagno, G. and others},
  title   = {{Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study}},
  journal = {The Lancet. Neurology},
  year    = {2012},
  doi     = {10.1016/s1474-4422(12)70043-1},
  pmid    = {22406228},
  url     = {https://doi.org/10.1016/s1474-4422(12)70043-1}
}

@article{kapogiannis2019-31305918,
  author  = {Kapogiannis, D. and Mustapic, M. and Shardell, M. D. and Berkowitz, S. T. and Diehl, T. C. and Spangler, R. D. and Tran, J. and Lazaropoulos, M. P. and others},
  title   = {{Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2019.2462},
  pmid    = {31305918},
  url     = {https://doi.org/10.1001/jamaneurol.2019.2462}
}

@article{tang2015-26334524,
  author  = {Tang, E. Y. and Harrison, S. L. and Errington, L. and Gordon, M. F. and Visser, P. J. and Novak, G. and Dufouil, C. and Brayne, C. and others},
  title   = {{Current Developments in Dementia Risk Prediction Modelling: An Updated Systematic Review}},
  journal = {PloS one},
  year    = {2015},
  doi     = {10.1371/journal.pone.0136181},
  pmid    = {26334524},
  url     = {https://doi.org/10.1371/journal.pone.0136181}
}

@article{gaitan2021-34093436,
  author  = {Gaitán, J. M. and Moon, H. Y. and Stremlau, M. and Dubal, D. B. and Cook, D. B. and Okonkwo, O. C. and van Praag, H.},
  title   = {{Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease}},
  journal = {Frontiers in endocrinology},
  year    = {2021},
  doi     = {10.3389/fendo.2021.660181},
  pmid    = {34093436},
  url     = {https://doi.org/10.3389/fendo.2021.660181}
}

@article{boyle2009-19414613,
  author  = {Boyle, P. A. and Barnes, L. L. and Buchman, A. S. and Bennett, D. A.},
  title   = {{Purpose in life is associated with mortality among community-dwelling older persons}},
  journal = {Psychosomatic medicine},
  year    = {2009},
  doi     = {10.1097/psy.0b013e3181a5a7c0},
  pmid    = {19414613},
  url     = {https://doi.org/10.1097/psy.0b013e3181a5a7c0}
}

@article{lee2019-30760848,
  author  = {Lee, G. and Nho, K. and Kang, B. and Sohn, K. A. and Kim, D. and {for Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Predicting Alzheimer's disease progression using multi-modal deep learning approach}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-018-37769-z},
  pmid    = {30760848},
  url     = {https://doi.org/10.1038/s41598-018-37769-z}
}

@article{sosa2012-22346736,
  author  = {Sosa, A. L. and Albanese, E. and Stephan, B. C. and Dewey, M. and Acosta, D. and Ferri, C. P. and Guerra, M. and Huang, Y. and others},
  title   = {{Prevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: a 10/66 population-based study}},
  journal = {PLoS medicine},
  year    = {2012},
  doi     = {10.1371/journal.pmed.1001170},
  pmid    = {22346736},
  url     = {https://doi.org/10.1371/journal.pmed.1001170}
}

@article{wen2022-35262657,
  author  = {Wen, J. and Fu, C. H. Y. and Tosun, D. and Veturi, Y. and Yang, Z. and Abdulkadir, A. and Mamourian, E. and Srinivasan, D. and others},
  title   = {{Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression}},
  journal = {JAMA psychiatry},
  year    = {2022},
  doi     = {10.1001/jamapsychiatry.2022.0020},
  pmid    = {35262657},
  url     = {https://doi.org/10.1001/jamapsychiatry.2022.0020}
}

@article{harold2009-19734902,
  author  = {Harold, Denise H. and Abraham, Richard and Hollingworth, Paul and Sims, Rebecca and Gerrish, Amy and Hamshere, Marian L. and Pahwa, Jaspreet Singh and Moskvina, Valentina and others},
  title   = {{Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2009},
  doi     = {10.1038/ng.440},
  pmid    = {19734902},
  url     = {https://doi.org/10.1038/ng.440}
}

@article{study2011-21460840,
  author  = {{the Alzheimer's Disease Neuroimaging Initiative} and Hollingworth, Paul and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Lambert, Jean‐Charles and Carrasquillo, Minerva M. and Abraham, Richard and others},
  title   = {{Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2011},
  doi     = {10.1038/ng.803},
  pmid    = {21460840},
  url     = {https://doi.org/10.1038/ng.803}
}

@article{giorgio2026-41936382,
  author  = {Giorgio, Katherine and Stephen, John J and Mansolf, Maxwell and Peterson, Elizabeth A and Gross, Alden L and Briceño, Emily M and Levine, Deborah A and Helmer, Catherine and others},
  title   = {{Risk factors for early-onset and late-onset dementia: a prospective cohort study}},
  journal = {The lancet. Healthy longevity},
  year    = {2026},
  doi     = {10.1016/j.lanhl.2026.100831},
  pmid    = {41936382},
  url     = {https://doi.org/10.1016/j.lanhl.2026.100831}
}

@article{grober2008-18282324,
  author  = {Grober, E. and Hall, C. B. and Lipton, R. B. and Zonderman, A. B. and Resnick, S. M. and Kawas, C.},
  title   = {{Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease}},
  journal = {Journal of the International Neuropsychological Society : JINS},
  year    = {2008},
  doi     = {10.1017/s1355617708080302},
  pmid    = {18282324},
  url     = {https://doi.org/10.1017/s1355617708080302}
}

@article{troncoso2008-18496870,
  author  = {Troncoso, J. C. and Zonderman, A. B. and Resnick, S. M. and Crain, B. and Pletnikova, O. and O'Brien, R. J.},
  title   = {{Effect of infarcts on dementia in the Baltimore longitudinal study of aging}},
  journal = {Annals of neurology},
  year    = {2008},
  doi     = {10.1002/ana.21413},
  pmid    = {18496870},
  url     = {https://doi.org/10.1002/ana.21413}
}

@article{caunca2020-32364578,
  author  = {Caunca, M. R. and Odden, M. C. and Glymour, M. M. and Elfassy, T. and Kershaw, K. N. and Sidney, S. and Yaffe, K. and Launer, L. and others},
  title   = {{Association of Racial Residential Segregation Throughout Young Adulthood and Cognitive Performance in Middle-aged Participants in the CARDIA Study}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.0860},
  pmid    = {32364578},
  url     = {https://doi.org/10.1001/jamaneurol.2020.0860}
}

@article{hardy2002-12130773,
  author  = {Hardy, John and Selkoe, Dennis J.},
  title   = {{The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics}},
  journal = {Science},
  year    = {2002},
  doi     = {10.1126/science.1072994},
  pmid    = {12130773},
  url     = {https://doi.org/10.1126/science.1072994}
}

@article{habes2018-30076276,
  author  = {Habes, M. and Sotiras, A. and Erus, G. and Toledo, J. B. and Janowitz, D. and Wolk, D. A. and Shou, H. and Bryan, N. R. and others},
  title   = {{White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000006116},
  pmid    = {30076276},
  url     = {https://doi.org/10.1212/wnl.0000000000006116}
}

@article{jack2018-29653606,
  author  = {Jack, C. R. and Bennett, D. A. and Blennow, K. and Carrillo, M. C. and Dunn, B. and Haeberlein, S. B. and Holtzman, D. M. and Jagust, W. and others},
  title   = {{NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2018},
  doi     = {10.1016/j.jalz.2018.02.018},
  pmid    = {29653606},
  url     = {https://doi.org/10.1016/j.jalz.2018.02.018}
}

@article{habes2016-26912649,
  author  = {Habes, M. and Erus, G. and Toledo, J. B. and Zhang, T. and Bryan, N. and Launer, L. J. and Rosseel, Y. and Janowitz, D. and others},
  title   = {{White matter hyperintensities and imaging patterns of brain ageing in the general population}},
  journal = {Brain : a journal of neurology},
  year    = {2016},
  doi     = {10.1093/brain/aww008},
  pmid    = {26912649},
  url     = {https://doi.org/10.1093/brain/aww008}
}

@article{resnick2010-20147655,
  author  = {Resnick, S. M. and Sojkova, J. and Zhou, Y. and An, Y. and Ye, W. and Holt, D. P. and Dannals, R. F. and Mathis, C. A. and others},
  title   = {{Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181d3e3e9},
  pmid    = {20147655},
  url     = {https://doi.org/10.1212/wnl.0b013e3181d3e3e9}
}

@article{yaffe2016-27397561,
  author  = {Yaffe, K. and Nasrallah, I. and Hoang, T. D. and Lauderdale, D. S. and Knutson, K. L. and Carnethon, M. R. and Launer, L. J. and Lewis, C. E. and others},
  title   = {{Sleep Duration and White Matter Quality in Middle-Aged Adults}},
  journal = {Sleep},
  year    = {2016},
  doi     = {10.5665/sleep.6104},
  pmid    = {27397561},
  url     = {https://doi.org/10.5665/sleep.6104}
}

@article{wang2022-35441085,
  author  = {Wang, Y. and Han, X. and Zhang, X. and Zhang, Z. and Cong, L. and Tang, S. and Hou, T. and Liu, C. and others},
  title   = {{Health status and risk profiles for brain aging of rural-dwelling older adults: Data from the interdisciplinary baseline assessments in MIND-China}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12254},
  pmid    = {35441085},
  url     = {https://doi.org/10.1002/trc2.12254}
}

@article{peila2002-11916953,
  author  = {Peila, R. and Rodriguez, B. L. and Launer, L. J. and {Honolulu-Asia Aging Study}},
  title   = {{Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study}},
  journal = {Diabetes},
  year    = {2002},
  doi     = {10.2337/diabetes.51.4.1256},
  pmid    = {11916953},
  url     = {https://doi.org/10.2337/diabetes.51.4.1256}
}

@article{lin2014-24412398,
  author  = {Lin, F. R. and Ferrucci, L. and An, Y. and Goh, J. O. and Doshi, J. and Metter, E. J. and Davatzikos, C. and Kraut, M. A. and others},
  title   = {{Association of hearing impairment with brain volume changes in older adults}},
  journal = {NeuroImage},
  year    = {2014},
  doi     = {10.1016/j.neuroimage.2013.12.059},
  pmid    = {24412398},
  url     = {https://doi.org/10.1016/j.neuroimage.2013.12.059}
}

@article{neumann2009-19286695,
  author  = {Neumann, J. and Bras, J. and Deas, E. and O'Sullivan, S. S. and Parkkinen, L. and Lachmann, R. H. and Li, A. and Holton, J. and others},
  title   = {{Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2009},
  doi     = {10.1093/brain/awp044},
  pmid    = {19286695},
  url     = {https://doi.org/10.1093/brain/awp044}
}

@article{montine2012-22101365,
  author  = {Montine, T. J. and Phelps, C. H. and Beach, T. G. and Bigio, E. H. and Cairns, N. J. and Dickson, D. W. and Duyckaerts, C. and Frosch, M. P. and others},
  title   = {{National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach}},
  journal = {Acta neuropathologica},
  year    = {2012},
  doi     = {10.1007/s00401-011-0910-3},
  pmid    = {22101365},
  url     = {https://doi.org/10.1007/s00401-011-0910-3}
}

@article{chia2021-33589841,
  author  = {Chia, R. and Sabir, M. S. and Bandres-Ciga, S. and Saez-Atienzar, S. and Reynolds, R. H. and Gustavsson, E. and Walton, R. L. and Ahmed, S. and others},
  title   = {{Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture}},
  journal = {Nature genetics},
  year    = {2021},
  doi     = {10.1038/s41588-021-00785-3},
  pmid    = {33589841},
  url     = {https://doi.org/10.1038/s41588-021-00785-3}
}

@article{thambisetty2012-21824521,
  author  = {Thambisetty, M. and An, Y. and Kinsey, A. and Koka, D. and Saleem, M. and Güntert, A. and Kraut, M. and Ferrucci, L. and others},
  title   = {{Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment}},
  journal = {NeuroImage},
  year    = {2012},
  doi     = {10.1016/j.neuroimage.2011.07.056},
  pmid    = {21824521},
  url     = {https://doi.org/10.1016/j.neuroimage.2011.07.056}
}

@article{desikan2015-25862742,
  author  = {Desikan, R. S. and Schork, A. J. and Wang, Y. and Thompson, W. K. and Dehghan, A. and Ridker, P. M. and Chasman, D. I. and McEvoy, L. K. and others},
  title   = {{Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease}},
  journal = {Circulation},
  year    = {2015},
  doi     = {10.1161/circulationaha.115.015489},
  pmid    = {25862742},
  url     = {https://doi.org/10.1161/circulationaha.115.015489}
}

@article{mitchell2011-22075523,
  author  = {Mitchell, G. F. and van Buchem, M. A. and Sigurdsson, S. and Gotal, J. D. and Jonsdottir, M. K. and Ó, Kjartansson and Garcia, M. and Aspelund, T. and others},
  title   = {{Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study}},
  journal = {Brain : a journal of neurology},
  year    = {2011},
  doi     = {10.1093/brain/awr253},
  pmid    = {22075523},
  url     = {https://doi.org/10.1093/brain/awr253}
}

@article{renton2011-21944779,
  author  = {Renton, A. E. and Majounie, E. and Waite, A. and Simón-Sánchez, J. and Rollinson, S. and Gibbs, JR. and Schymick, J. C. and Laaksovirta, H. and others},
  title   = {{A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD}},
  journal = {Neuron},
  year    = {2011},
  doi     = {10.1016/j.neuron.2011.09.010},
  pmid    = {21944779},
  url     = {https://doi.org/10.1016/j.neuron.2011.09.010}
}

@article{hyman2012-22265587,
  author  = {Hyman, B. T. and Phelps, C. H. and Beach, T. G. and Bigio, E. H. and Cairns, N. J. and Carrillo, M. C. and Dickson, D. W. and Duyckaerts, C. and others},
  title   = {{National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2012},
  doi     = {10.1016/j.jalz.2011.10.007},
  pmid    = {22265587},
  url     = {https://doi.org/10.1016/j.jalz.2011.10.007}
}

@article{goetzl2016-27601437,
  author  = {Goetzl, E. J. and Kapogiannis, D. and Schwartz, J. B. and Lobach, IV. and Goetzl, L. and Abner, E. L. and Jicha, G. A. and Karydas, A. M. and others},
  title   = {{Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2016},
  doi     = {10.1096/fj.201600816r},
  pmid    = {27601437},
  url     = {https://doi.org/10.1096/fj.201600816r}
}

@article{walker2021-37118015,
  author  = {Walker, K. A. and Chen, J. and Zhang, J. and Fornage, M. and Yang, Y. and Zhou, L. and Grams, M. E. and Tin, A. and others},
  title   = {{Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk}},
  journal = {Nature aging},
  year    = {2021},
  doi     = {10.1038/s43587-021-00064-0},
  pmid    = {37118015},
  url     = {https://doi.org/10.1038/s43587-021-00064-0}
}

@article{govindarajan2025-40108173,
  author  = {Govindarajan, Sindhuja Tirumalai and Mamourian, Elizabeth and Erus, Güray and Abdulkadir, Ahmed and Melhem, Randa and Doshi, Jimit J. and Pomponio, Raymond and Tosun, Duygu and others},
  title   = {{Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals}},
  journal = {Nature Communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-57867-7},
  pmid    = {40108173},
  url     = {https://doi.org/10.1038/s41467-025-57867-7}
}

@article{winblad2004-15324367,
  author  = {Winblad, Bengt G. and Palmer, Katie and Kivipelto, Miia and Jelić, Vesna and Fratiglioni, Laura and Wahlund, Lars‐Olof and Nordberg, Agneta K. and Bäckman, Lars and others},
  title   = {{Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment}},
  journal = {Journal of Internal Medicine},
  year    = {2004},
  doi     = {10.1111/j.1365-2796.2004.01380.x},
  pmid    = {15324367},
  url     = {https://doi.org/10.1111/j.1365-2796.2004.01380.x}
}

@article{oddo2003-12895417,
  author  = {Oddo, Salvatore and Caccamo, Antonella and Shepherd, Jason D. and Murphy, Michael Paul and Golde, Todd Eliot and Kayed, Rakez and Metherate, Raju and Mattson, Mark P. and others},
  title   = {{Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00434-3},
  pmid    = {12895417},
  url     = {https://doi.org/10.1016/s0896-6273(03)00434-3}
}

@article{simuni2024-38267190,
  author  = {Simuni, T. and Chahine, L. M. and Poston, K. and Brumm, M. and Buracchio, T. and Campbell, M. and Chowdhury, S. and Coffey, C. and others},
  title   = {{A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research}},
  journal = {The Lancet. Neurology},
  year    = {2024},
  doi     = {10.1016/s1474-4422(23)00405-2},
  pmid    = {38267190},
  url     = {https://doi.org/10.1016/s1474-4422(23)00405-2}
}

@article{goetzl2015-26062630,
  author  = {Goetzl, E. J. and Boxer, A. and Schwartz, J. B. and Abner, E. L. and Petersen, R. C. and Miller, B. L. and Kapogiannis, D.},
  title   = {{Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000001702},
  pmid    = {26062630},
  url     = {https://doi.org/10.1212/wnl.0000000000001702}
}

@article{katzmarzyk2022-33782046,
  author  = {Katzmarzyk, P. T. and Friedenreich, C. and Shiroma, E. J. and Lee, I. M.},
  title   = {{Physical inactivity and non-communicable disease burden in low-income, middle-income and high-income countries}},
  journal = {British journal of sports medicine},
  year    = {2022},
  doi     = {10.1136/bjsports-2020-103640},
  pmid    = {33782046},
  url     = {https://doi.org/10.1136/bjsports-2020-103640}
}

@article{kalmijn2000-11031212,
  author  = {Kalmijn, S. and Foley, D. and White, L. and Burchfiel, C. M. and Curb, J. D. and Petrovitch, H. and Ross, G. W. and Havlik, R. J. and others},
  title   = {{Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2000},
  doi     = {10.1161/01.atv.20.10.2255},
  pmid    = {11031212},
  url     = {https://doi.org/10.1161/01.atv.20.10.2255}
}

@article{greenberg2009-19161908,
  author  = {Greenberg, S. M. and Vernooij, M. W. and Cordonnier, C. and Viswanathan, A. and Al-Shahi Salman, R. and Warach, S. and Launer, L. J. and Van Buchem, M. A. and others},
  title   = {{Cerebral microbleeds: a guide to detection and interpretation}},
  journal = {The Lancet. Neurology},
  year    = {2009},
  doi     = {10.1016/s1474-4422(09)70013-4},
  pmid    = {19161908},
  url     = {https://doi.org/10.1016/s1474-4422(09)70013-4}
}

@article{fiandaca2015-25130657,
  author  = {Fiandaca, M. S. and Kapogiannis, D. and Mapstone, M. and Boxer, A. and Eitan, E. and Schwartz, J. B. and Abner, E. L. and Petersen, R. C. and others},
  title   = {{Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.06.008},
  pmid    = {25130657},
  url     = {https://doi.org/10.1016/j.jalz.2014.06.008}
}

@article{davatzikos2009-19416949,
  author  = {Davatzikos, C. and Xu, F. and An, Y. and Fan, Y. and Resnick, S. M.},
  title   = {{Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index}},
  journal = {Brain : a journal of neurology},
  year    = {2009},
  doi     = {10.1093/brain/awp091},
  pmid    = {19416949},
  url     = {https://doi.org/10.1093/brain/awp091}
}

@article{weinstein2019-30768625,
  author  = {Weinstein, G. and Davis-Plourde, K. L. and Conner, S. and Himali, J. J. and Beiser, A. S. and Lee, A. and Rawlings, A. M. and Sedaghat, S. and others},
  title   = {{Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts}},
  journal = {PloS one},
  year    = {2019},
  doi     = {10.1371/journal.pone.0212293},
  pmid    = {30768625},
  url     = {https://doi.org/10.1371/journal.pone.0212293}
}

@article{cooperknock2012-22366792,
  author  = {Cooper-Knock, J. and Hewitt, C. and Highley, JR. and Brockington, A. and Milano, A. and Man, S. and Martindale, J. and Hartley, J. and others},
  title   = {{Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72}},
  journal = {Brain : a journal of neurology},
  year    = {2012},
  doi     = {10.1093/brain/awr365},
  pmid    = {22366792},
  url     = {https://doi.org/10.1093/brain/awr365}
}

@article{kivipelto2020-32627328,
  author  = {Kivipelto, M. and Mangialasche, F. and Snyder, H. M. and Allegri, R. and Andrieu, S. and Arai, H. and Baker, L. and Belleville, S. and others},
  title   = {{World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12123},
  pmid    = {32627328},
  url     = {https://doi.org/10.1002/alz.12123}
}

@article{mckhann2011-21514250,
  author  = {McKhann, G. M. and Knopman, D. S. and Chertkow, H. and Hyman, B. T. and Jack, C. R. and Kawas, C. H. and Klunk, W. E. and Koroshetz, W. J. and others},
  title   = {{The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2011},
  doi     = {10.1016/j.jalz.2011.03.005},
  pmid    = {21514250},
  url     = {https://doi.org/10.1016/j.jalz.2011.03.005}
}

@article{mayeux1998-9468467,
  author  = {Mayeux, R. and Saunders, A. M. and Shea, S. and Mirra, S. and Evans, D. and Roses, A. D. and Hyman, B. T. and Crain, B. and others},
  title   = {{Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {1998},
  doi     = {10.1056/nejm199802193380804},
  pmid    = {9468467},
  url     = {https://doi.org/10.1056/nejm199802193380804}
}

@article{dubois2024-39483064,
  author  = {Dubois, B. and Villain, N. and Schneider, L. and Fox, N. and Campbell, N. and Galasko, D. and Kivipelto, M. and Jessen, F. and others},
  title   = {{Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation}},
  journal = {JAMA neurology},
  year    = {2024},
  doi     = {10.1001/jamaneurol.2024.3770},
  pmid    = {39483064},
  url     = {https://doi.org/10.1001/jamaneurol.2024.3770}
}

@article{kaup2015-25599330,
  author  = {Kaup, A. R. and Nettiksimmons, J. and Harris, T. B. and Sink, K. M. and Satterfield, S. and Metti, A. L. and Ayonayon, H. N. and Yaffe, K. and others},
  title   = {{Cognitive resilience to apolipoprotein E ε4: contributing factors in black and white older adults}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.3978},
  pmid    = {25599330},
  url     = {https://doi.org/10.1001/jamaneurol.2014.3978}
}

@article{lin2011-21728425,
  author  = {Lin, F. R. and Ferrucci, L. and Metter, E. J. and An, Y. and Zonderman, A. B. and Resnick, S. M.},
  title   = {{Hearing loss and cognition in the Baltimore Longitudinal Study of Aging}},
  journal = {Neuropsychology},
  year    = {2011},
  doi     = {10.1037/a0024238},
  pmid    = {21728425},
  url     = {https://doi.org/10.1037/a0024238}
}

@article{petrovitch2000-10794849,
  author  = {Petrovitch, H. and White, L. R. and Izmirilian, G. and Ross, G. W. and Havlik, R. J. and Markesbery, W. and Nelson, J. and Davis, D. G. and others},
  title   = {{Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study}},
  journal = {Neurobiology of aging},
  year    = {2000},
  doi     = {10.1016/s0197-4580(00)00106-8},
  pmid    = {10794849},
  url     = {https://doi.org/10.1016/s0197-4580(00)00106-8}
}

@article{izquierdo2021-34409961,
  author  = {Izquierdo, M. and Merchant, R. A. and Morley, J. E. and Anker, S. D. and Aprahamian, I. and Arai, H. and Aubertin-Leheudre, M. and Bernabei, R. and others},
  title   = {{International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines}},
  journal = {The journal of nutrition, health \& aging},
  year    = {2021},
  doi     = {10.1007/s12603-021-1665-8},
  pmid    = {34409961},
  url     = {https://doi.org/10.1007/s12603-021-1665-8}
}

@article{iacono2008-18520776,
  author  = {Iacono, D. and O'Brien, R. and Resnick, S. M. and Zonderman, A. B. and Pletnikova, O. and Rudow, G. and An, Y. and West, M. J. and others},
  title   = {{Neuronal hypertrophy in asymptomatic Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2008},
  doi     = {10.1097/nen.0b013e3181772794},
  pmid    = {18520776},
  url     = {https://doi.org/10.1097/nen.0b013e3181772794}
}

@article{vanderlee2019-31131421,
  author  = {van der Lee, S. J. and Conway, O. J. and Jansen, I. and Carrasquillo, M. M. and Kleineidam, L. and van den Akker, E. and Hernández, I. and van Eijk, K. R. and others},
  title   = {{A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02026-8},
  pmid    = {31131421},
  url     = {https://doi.org/10.1007/s00401-019-02026-8}
}

@article{lindbohm2022-34338426,
  author  = {Lindbohm, J. V. and Mars, N. and Walker, K. A. and Singh-Manoux, A. and Livingston, G. and Brunner, E. J. and Sipilä, P. N. and Saksela, K. and others},
  title   = {{Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12419},
  pmid    = {34338426},
  url     = {https://doi.org/10.1002/alz.12419}
}

@article{dark2025-39889254,
  author  = {Dark, Heather E. and Shafer, Andrea T. and Cordon, Jenifer and An, Yang and Lewis, Alexandria and Moghekar, Abhay and Landman, Bennett A. and Resnick, Susan M. and others},
  title   = {{Association of Plasma Biomarkers of Alzheimer Disease and Neurodegeneration With Longitudinal Intra-Network Functional Brain Connectivity}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000210271},
  pmid    = {39889254},
  url     = {https://doi.org/10.1212/wnl.0000000000210271}
}

@article{albert2011-21514249,
  author  = {Albert, Marilyn S. and DeKosky, Steven T. and Dickson, Dennis W. and Dubois, Bruno and Feldman, Howard and Fox, Nick C. and Gamst, Anthony C. and Holtzman, David M. and others},
  title   = {{The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2011},
  doi     = {10.1016/j.jalz.2011.03.008},
  pmid    = {21514249},
  url     = {https://doi.org/10.1016/j.jalz.2011.03.008}
}

@article{hazan2024-39353147,
  author  = {Hazan, J. and Liu, K. Y. and Costello, H. and Isaacs, J. D. and Thambisetty, M. and Howard, R.},
  title   = {{Challenges in a Biological Definition of Alzheimer Disease}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000209884},
  pmid    = {39353147},
  url     = {https://doi.org/10.1212/wnl.0000000000209884}
}

@article{talegawkar2012-23096005,
  author  = {Talegawkar, S. A. and Bandinelli, S. and Bandeen-Roche, K. and Chen, P. and Milaneschi, Y. and Tanaka, T. and Semba, R. D. and Guralnik, J. M. and others},
  title   = {{A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women}},
  journal = {The Journal of nutrition},
  year    = {2012},
  doi     = {10.3945/jn.112.165498},
  pmid    = {23096005},
  url     = {https://doi.org/10.3945/jn.112.165498}
}

@article{lo2012-22972646,
  author  = {Lo, R. Y. and Jagust, W. J. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Vascular burden and Alzheimer disease pathologic progression}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e31826c1b9d},
  pmid    = {22972646},
  url     = {https://doi.org/10.1212/wnl.0b013e31826c1b9d}
}

@article{yaffe2011-21245181,
  author  = {Yaffe, K. and Weston, A. and Graff-Radford, N. R. and Satterfield, S. and Simonsick, E. M. and Younkin, S. G. and Younkin, L. H. and Kuller, L. and others},
  title   = {{Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline}},
  journal = {JAMA},
  year    = {2011},
  doi     = {10.1001/jama.2010.1995},
  pmid    = {21245181},
  url     = {https://doi.org/10.1001/jama.2010.1995}
}

@article{yaffe2017-28039314,
  author  = {Yaffe, K. and Freimer, D. and Chen, H. and Asao, K. and Rosso, A. and Rubin, S. and Tranah, G. and Cummings, S. and others},
  title   = {{Olfaction and risk of dementia in a biracial cohort of older adults}},
  journal = {Neurology},
  year    = {2017},
  doi     = {10.1212/wnl.0000000000003558},
  pmid    = {28039314},
  url     = {https://doi.org/10.1212/wnl.0000000000003558}
}

@article{qiu2010-21172845,
  author  = {Qiu, C. and Cotch, M. F. and Sigurdsson, S. and Jonsson, P. V. and Jonsdottir, M. K. and Sveinbjrnsdottir, S. and Eiriksdottir, G. and Klein, R. and others},
  title   = {{Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3182020349},
  pmid    = {21172845},
  url     = {https://doi.org/10.1212/wnl.0b013e3182020349}
}

@article{pfeifer2002-12058090,
  author  = {Pfeifer, L. A. and White, L. R. and Ross, G. W. and Petrovitch, H. and Launer, L. J.},
  title   = {{Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study}},
  journal = {Neurology},
  year    = {2002},
  doi     = {10.1212/wnl.58.11.1629},
  pmid    = {12058090},
  url     = {https://doi.org/10.1212/wnl.58.11.1629}
}

@article{duggan2022-35985823,
  author  = {Duggan, M. R. and Peng, Z. and An, Y. and Kitner Triolo, M. H. and Shafer, A. T. and Davatzikos, C. and Erus, G. and Karikkineth, A. and others},
  title   = {{Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000201036},
  pmid    = {35985823},
  url     = {https://doi.org/10.1212/wnl.0000000000201036}
}

@article{deal2017-27071780,
  author  = {Deal, J. A. and Betz, J. and Yaffe, K. and Harris, T. and Purchase-Helzner, E. and Satterfield, S. and Pratt, S. and Govil, N. and others},
  title   = {{Hearing Impairment and Incident Dementia and Cognitive Decline in Older Adults: The Health ABC Study}},
  journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
  year    = {2017},
  doi     = {10.1093/gerona/glw069},
  pmid    = {27071780},
  url     = {https://doi.org/10.1093/gerona/glw069}
}

@article{plassman2000-11071494,
  author  = {Plassman, B. L. and Havlik, R. J. and Steffens, D. C. and Helms, M. J. and Newman, T. N. and Drosdick, D. and Phillips, C. and Gau, B. A. and others},
  title   = {{Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias}},
  journal = {Neurology},
  year    = {2000},
  doi     = {10.1212/wnl.55.8.1158},
  pmid    = {11071494},
  url     = {https://doi.org/10.1212/wnl.55.8.1158}
}

@article{goodman2017-27172148,
  author  = {Goodman, R. A. and Lochner, K. A. and Thambisetty, M. and Wingo, T. S. and Posner, S. F. and Ling, S. M.},
  title   = {{Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011-2013}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.04.002},
  pmid    = {27172148},
  url     = {https://doi.org/10.1016/j.jalz.2016.04.002}
}

@article{chen2021-34537810,
  author  = {Chen, S. D. and Lu, J. Y. and Li, H. Q. and Yang, Y. X. and Jiang, J. H. and Cui, M. and Zuo, C. T. and Tan, L. and others},
  title   = {{Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study}},
  journal = {Translational psychiatry},
  year    = {2021},
  doi     = {10.1038/s41398-021-01602-5},
  pmid    = {34537810},
  url     = {https://doi.org/10.1038/s41398-021-01602-5}
}

@article{jacobs2020-32934108,
  author  = {Jacobs, B. M. and Belete, D. and Bestwick, J. and Blauwendraat, C. and Bandres-Ciga, S. and Heilbron, K. and Dobson, R. and Nalls, M. A. and others},
  title   = {{Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2020},
  doi     = {10.1136/jnnp-2020-323646},
  pmid    = {32934108},
  url     = {https://doi.org/10.1136/jnnp-2020-323646}
}

@article{duggan2025-39936291,
  author  = {Duggan, Michael R. and Paterson, Clare and Lü, Yifei and Biegel, Hannah and Dark, Heather E. and Cordon, Jenifer and Bilgel, Murat and Kaneko, Naoto and others},
  title   = {{The Dementia SomaSignal Test (dSST): A plasma proteomic predictor of 20‐year dementia risk}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.14549},
  pmid    = {39936291},
  url     = {https://doi.org/10.1002/alz.14549}
}

@article{morrill2026-42385118,
  author  = {Morrill, V. N. and Pike, JR. and Hu, J. and Fornage, M. and Surapaneni, A. and Walker, K. A. and Knopman, D. S. and Mosley, T. H. and Coresh, J. and Schneider, A. L. C. and others},
  title   = {{Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/WNL.0000000000218280},
  pmid    = {42385118},
  url     = {https://doi.org/10.1212/WNL.0000000000218280}
}

@article{jack2011-21514247,
  author  = {Jack, C. R. and Albert, M. S. and Knopman, D. S. and McKhann, G. M. and Sperling, R. A. and Carrillo, M. C. and Thies, B. and Phelps, C. H.},
  title   = {{Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2011},
  doi     = {10.1016/j.jalz.2011.03.004},
  pmid    = {21514247},
  url     = {https://doi.org/10.1016/j.jalz.2011.03.004}
}

@article{beydoun2012-20619505,
  author  = {Beydoun, M. A. and Boueiz, A. and Abougergi, M. S. and Kitner-Triolo, M. H. and Beydoun, H. A. and Resnick, S. M. and O'Brien, R. and Zonderman, A. B.},
  title   = {{Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2010.05.017},
  pmid    = {20619505},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2010.05.017}
}

@article{newman2009-19723772,
  author  = {Newman, A. B. and Sachs, M. C. and Arnold, A. M. and Fried, L. P. and Kronmal, R. and Cushman, M. and Psaty, B. M. and Harris, T. B. and others},
  title   = {{Total and cause-specific mortality in the cardiovascular health study}},
  journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
  year    = {2009},
  doi     = {10.1093/gerona/glp127},
  pmid    = {19723772},
  url     = {https://doi.org/10.1093/gerona/glp127}
}

@article{schmidt2002-12210786,
  author  = {Schmidt, R. and Schmidt, H. and Curb, J. D. and Masaki, K. and White, L. R. and Launer, L. J.},
  title   = {{Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study}},
  journal = {Annals of neurology},
  year    = {2002},
  doi     = {10.1002/ana.10265},
  pmid    = {12210786},
  url     = {https://doi.org/10.1002/ana.10265}
}

@article{shvetcov2025-40665049,
  author  = {Shvetcov, A. and Johnson, E. C. B. and Winchester, L. M. and Walker, K. A. and Wilkins, H. M. and Thompson, T. G. and Rothstein, J. D. and Krish, V. and others},
  title   = {{APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases}},
  journal = {Nature medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03835-z},
  pmid    = {40665049},
  url     = {https://doi.org/10.1038/s41591-025-03835-z}
}

@article{martens2022-35298921,
  author  = {Martens, Y. A. and Zhao, N. and Liu, C. C. and Kanekiyo, T. and Yang, A. J. and Goate, A. M. and Holtzman, D. M. and Bu, G.},
  title   = {{ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias}},
  journal = {Neuron},
  year    = {2022},
  doi     = {10.1016/j.neuron.2022.03.004},
  pmid    = {35298921},
  url     = {https://doi.org/10.1016/j.neuron.2022.03.004}
}

@article{paisanruiz2004-15541308,
  author  = {Paisán-Ruíz, C. and Jain, S. and Evans, E. W. and Gilks, W. P. and Simón, J. and van der Brug, M. and López de Munain, A. and Aparicio, S. and others},
  title   = {{Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease}},
  journal = {Neuron},
  year    = {2004},
  doi     = {10.1016/j.neuron.2004.10.023},
  pmid    = {15541308},
  url     = {https://doi.org/10.1016/j.neuron.2004.10.023}
}

@article{johnson2014-24686783,
  author  = {Johnson, J. O. and Pioro, E. P. and Boehringer, A. and Chia, R. and Feit, H. and Renton, A. E. and Pliner, H. A. and Abramzon, Y. and others},
  title   = {{Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis}},
  journal = {Nature neuroscience},
  year    = {2014},
  doi     = {10.1038/nn.3688},
  pmid    = {24686783},
  url     = {https://doi.org/10.1038/nn.3688}
}

@article{goetzl2018-29406582,
  author  = {Goetzl, E. J. and Schwartz, J. B. and Abner, E. L. and Jicha, G. A. and Kapogiannis, D.},
  title   = {{High complement levels in astrocyte-derived exosomes of Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2018},
  doi     = {10.1002/ana.25172},
  pmid    = {29406582},
  url     = {https://doi.org/10.1002/ana.25172}
}

@article{caviedes2026-41688826,
  author  = {Caviedes, A. and Cabral-Miranda, F. and Orellana, P. and Hernández, H. and Henríquez, F. and Gonzalez-Gomez, R. and Pizarro, M. and Migeot, J. and Ochoa-Rosales, C. and Gonzalez-Silva, C. and Marin-Diaz, N. and Coronel-Oliveros, C. and others},
  title   = {{Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America}},
  journal = {Nature Aging},
  year    = {2026},
  doi     = {10.1038/s43587-025-01061-3},
  pmid    = {41688826},
  url     = {https://doi.org/10.1038/s43587-025-01061-3}
}

@article{thambisetty2010-20065135,
  author  = {Thambisetty, M. and Beason-Held, L. and An, Y. and Kraut, M. A. and Resnick, S. M.},
  title   = {{APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2009.913},
  pmid    = {20065135},
  url     = {https://doi.org/10.1001/archneurol.2009.913}
}

@article{westwood2014-24706014,
  author  = {Westwood, A. J. and Beiser, A. and Decarli, C. and Harris, T. B. and Chen, T. C. and He, X. M. and Roubenoff, R. and Pikula, A. and others},
  title   = {{Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000382},
  pmid    = {24706014},
  url     = {https://doi.org/10.1212/wnl.0000000000000382}
}

@article{habes2016-27045845,
  author  = {Habes, M. and Janowitz, D. and Erus, G. and Toledo, J. B. and Resnick, S. M. and Doshi, J. and Van der Auwera, S. and Wittfeld, K. and others},
  title   = {{Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns}},
  journal = {Translational psychiatry},
  year    = {2016},
  doi     = {10.1038/tp.2016.39},
  pmid    = {27045845},
  url     = {https://doi.org/10.1038/tp.2016.39}
}

@article{ross2008-18067173,
  author  = {Ross, G. W. and Petrovitch, H. and Abbott, R. D. and Tanner, C. M. and Popper, J. and Masaki, K. and Launer, L. and White, L. R.},
  title   = {{Association of olfactory dysfunction with risk for future Parkinson's disease}},
  journal = {Annals of neurology},
  year    = {2008},
  doi     = {10.1002/ana.21291},
  pmid    = {18067173},
  url     = {https://doi.org/10.1002/ana.21291}
}

@article{guerreiro2013-23318515,
  author  = {Guerreiro, R. J. and Lohmann, E. and Brás, J. M. and Gibbs, JR. and Rohrer, J. D. and Gurunlian, N. and Dursun, B. and Bilgic, B. and others},
  title   = {{Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.579},
  pmid    = {23318515},
  url     = {https://doi.org/10.1001/jamaneurol.2013.579}
}

@article{sojkova2011-21320990,
  author  = {Sojkova, J. and Driscoll, I. and Iacono, D. and Zhou, Y. and Codispoti, K. E. and Kraut, M. A. and Ferrucci, L. and Pletnikova, O. and others},
  title   = {{In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.357},
  pmid    = {21320990},
  url     = {https://doi.org/10.1001/archneurol.2010.357}
}

@article{cummings1997-9153155,
  author  = {Cummings, J. L.},
  title   = {{The Neuropsychiatric Inventory: assessing psychopathology in dementia patients}},
  journal = {Neurology},
  year    = {1997},
  doi     = {10.1212/wnl.48.5_suppl_6.10s},
  pmid    = {9153155},
  url     = {https://doi.org/10.1212/wnl.48.5_suppl_6.10s}
}

@article{connell1997-9203759,
  author  = {Connell, C. M. and Gibson, G. D.},
  title   = {{Racial, ethnic, and cultural differences in dementia caregiving: review and analysis}},
  journal = {The Gerontologist},
  year    = {1997},
  doi     = {10.1093/geront/37.3.355},
  pmid    = {9203759},
  url     = {https://doi.org/10.1093/geront/37.3.355}
}

@article{lennon2022-34854531,
  author  = {Lennon, J. C. and Aita, S. L. and Bene, V. A. D. and Rhoads, T. and Resch, Z. J. and Eloi, J. M. and Walker, K. A.},
  title   = {{Black and White individuals differ in dementia prevalence, risk factors, and symptomatic presentation}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12509},
  pmid    = {34854531},
  url     = {https://doi.org/10.1002/alz.12509}
}

@article{white1996-8805729,
  author  = {White, L. and Petrovitch, H. and Ross, G. W. and Masaki, K. H. and Abbott, R. D. and Teng, E. L. and Rodriguez, B. L. and Blanchette, P. L. and others},
  title   = {{Prevalence of dementia in older Japanese-American men in Hawaii: The Honolulu-Asia Aging Study}},
  journal = {JAMA},
  year    = {1996},
  doi     = {10.1001/jama.1996.03540120033030},
  pmid    = {8805729},
  url     = {https://doi.org/10.1001/jama.1996.03540120033030}
}

@article{vansloten2020-32135131,
  author  = {van Sloten, T. T. and Sedaghat, S. and Carnethon, M. R. and Launer, L. J. and Stehouwer, C. D. A.},
  title   = {{Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression}},
  journal = {The lancet. Diabetes \& endocrinology},
  year    = {2020},
  doi     = {10.1016/s2213-8587(19)30405-x},
  pmid    = {32135131},
  url     = {https://doi.org/10.1016/s2213-8587(19)30405-x}
}

@article{donnelly2013-24139042,
  author  = {Donnelly, C. J. and Zhang, P. W. and Pham, J. T. and Haeusler, A. R. and Mistry, N. A. and Vidensky, S. and Daley, E. L. and Poth, E. M. and others},
  title   = {{RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention}},
  journal = {Neuron},
  year    = {2013},
  doi     = {10.1016/j.neuron.2013.10.015},
  pmid    = {24139042},
  url     = {https://doi.org/10.1016/j.neuron.2013.10.015}
}

@article{webster2009-19361613,
  author  = {Webster, J. A. and Gibbs, JR. and Clarke, J. and Ray, M. and Zhang, W. and Holmans, P. and Rohrer, K. and Zhao, A. and others},
  title   = {{Genetic control of human brain transcript expression in Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {2009},
  doi     = {10.1016/j.ajhg.2009.03.011},
  pmid    = {19361613},
  url     = {https://doi.org/10.1016/j.ajhg.2009.03.011}
}

@article{sedaghat2025-40813726,
  author  = {Sedaghat, Sanaz and Park, Saeun and Walker, Rob F. and Wang, Shuo and Liu, Jialing and Hughes, Timothy M. and Sabayan, Behnam and Tang, Weihong and others},
  title   = {{Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia}},
  journal = {Communications Medicine},
  year    = {2025},
  doi     = {10.1038/s43856-025-01096-y},
  pmid    = {40813726},
  url     = {https://doi.org/10.1038/s43856-025-01096-y}
}

@article{brookmeyer1998-9736873,
  author  = {Brookmeyer, Ron and Gray, Steven G. and Kawas, Claudia H.},
  title   = {{Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset}},
  journal = {American Journal of Public Health},
  year    = {1998},
  doi     = {10.2105/ajph.88.9.1337},
  pmid    = {9736873},
  url     = {https://doi.org/10.2105/ajph.88.9.1337}
}

@article{lu2024-38471046,
  author  = {Lu, Y. and Pike, JR. and Hoogeveen, R. and Walker, K. and Raffield, L. and Selvin, E. and Avery, C. and Engel, S. and others},
  title   = {{Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000209203},
  pmid    = {38471046},
  url     = {https://doi.org/10.1212/wnl.0000000000209203}
}

@article{launer2000-10794848,
  author  = {Launer, L. J. and Ross, G. W. and Petrovitch, H. and Masaki, K. and Foley, D. and White, L. R. and Havlik, R. J.},
  title   = {{Midlife blood pressure and dementia: the Honolulu-Asia aging study}},
  journal = {Neurobiology of aging},
  year    = {2000},
  doi     = {10.1016/s0197-4580(00)00096-8},
  pmid    = {10794848},
  url     = {https://doi.org/10.1016/s0197-4580(00)00096-8}
}

@article{turner2013-23415570,
  author  = {Turner, M. R. and Hardiman, O. and Benatar, M. and Brooks, B. R. and Chio, A. and de Carvalho, M. and Ince, P. G. and Lin, C. and others},
  title   = {{Controversies and priorities in amyotrophic lateral sclerosis}},
  journal = {The Lancet. Neurology},
  year    = {2013},
  doi     = {10.1016/s1474-4422(13)70036-x},
  pmid    = {23415570},
  url     = {https://doi.org/10.1016/s1474-4422(13)70036-x}
}

@article{toledo2017-28341160,
  author  = {Toledo, J. B. and Arnold, M. and Kastenmüller, G. and Chang, R. and Baillie, R. A. and Han, X. and Thambisetty, M. and Tenenbaum, J. D. and others},
  title   = {{Metabolic network failures in Alzheimer's disease: A biochemical road map}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2017.01.020},
  pmid    = {28341160},
  url     = {https://doi.org/10.1016/j.jalz.2017.01.020}
}

@article{tosun2024-38770829,
  author  = {Tosun, D. and Hausle, Z. and Iwaki, H. and Thropp, P. and Lamoureux, J. and Lee, E. B. and MacLeod, K. and McEvoy, S. and others},
  title   = {{A cross-sectional study of α-synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13858},
  pmid    = {38770829},
  url     = {https://doi.org/10.1002/alz.13858}
}

@article{jones2010-21085570,
  author  = {Jones, L. and Holmans, P. A. and Hamshere, M. L. and Harold, D. and Moskvina, V. and Ivanov, D. and Pocklington, A. and Abraham, R. and others},
  title   = {{Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0013950},
  pmid    = {21085570},
  url     = {https://doi.org/10.1371/journal.pone.0013950}
}

@article{strozyk2003-12601108,
  author  = {Strozyk, D. and Blennow, K. and White, L. R. and Launer, L. J.},
  title   = {{CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study}},
  journal = {Neurology},
  year    = {2003},
  doi     = {10.1212/01.wnl.0000046581.81650.d0},
  pmid    = {12601108},
  url     = {https://doi.org/10.1212/01.wnl.0000046581.81650.d0}
}

@article{elbejjani2019-30741945,
  author  = {Elbejjani, M. and Auer, R. and Jacobs, D. R. and Haight, T. and Davatzikos, C. and Goff, D. C. and Bryan, R. N. and Launer, L. J.},
  title   = {{Cigarette smoking and gray matter brain volumes in middle age adults: the CARDIA Brain MRI sub-study}},
  journal = {Translational psychiatry},
  year    = {2019},
  doi     = {10.1038/s41398-019-0401-1},
  pmid    = {30741945},
  url     = {https://doi.org/10.1038/s41398-019-0401-1}
}

@article{cacciottolo2017-28140404,
  author  = {Cacciottolo, M. and Wang, X. and Driscoll, I. and Woodward, N. and Saffari, A. and Reyes, J. and Serre, M. L. and Vizuete, W. and others},
  title   = {{Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models}},
  journal = {Translational psychiatry},
  year    = {2017},
  doi     = {10.1038/tp.2016.280},
  pmid    = {28140404},
  url     = {https://doi.org/10.1038/tp.2016.280}
}

@article{bachman1992-1734291,
  author  = {Bachman, D. L. and Wolf, P. A. and Linn, R. and Knoefel, J. E. and Cobb, J. and Belanger, A. and D'Agostino, R. B. and White, L. R.},
  title   = {{Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study}},
  journal = {Neurology},
  year    = {1992},
  doi     = {10.1212/wnl.42.1.115},
  pmid    = {1734291},
  url     = {https://doi.org/10.1212/wnl.42.1.115}
}

@article{bowman2017-28566307,
  author  = {Bowman, K. and Atkins, J. L. and Delgado, J. and Kos, K. and Kuchel, G. A. and Ble, A. and Ferrucci, L. and Melzer, D.},
  title   = {{Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants}},
  journal = {The American journal of clinical nutrition},
  year    = {2017},
  doi     = {10.3945/ajcn.116.147157},
  pmid    = {28566307},
  url     = {https://doi.org/10.3945/ajcn.116.147157}
}

@article{jones2026-42639394,
  author  = {Jones, Lietsel and Cerquera‐Cleves, Catalina and Schuh, Artur Francisco Schumacher and Makarious, Mary B. and Iwaki, Hirotaka and Nalls, Mike A. and Noyce, Alastair John and Blauwendraat, Cornelis and others},
  title   = {{Population Attributable Risk in Alzheimer and Parkinson Diseases}},
  journal = {Neurology Genetics},
  year    = {2026},
  doi     = {10.1212/nxg.0000000000200415},
  pmid    = {42639394},
  url     = {https://doi.org/10.1212/nxg.0000000000200415}
}

@article{zieman2005-15731494,
  author  = {Zieman, S. J. and Melenovsky, V. and Kass, D. A.},
  title   = {{Mechanisms, pathophysiology, and therapy of arterial stiffness}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2005},
  doi     = {10.1161/01.atv.0000160548.78317.29},
  pmid    = {15731494},
  url     = {https://doi.org/10.1161/01.atv.0000160548.78317.29}
}

@article{ferrucci2018-30065258,
  author  = {Ferrucci, L. and Fabbri, E.},
  title   = {{Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty}},
  journal = {Nature reviews. Cardiology},
  year    = {2018},
  doi     = {10.1038/s41569-018-0064-2},
  pmid    = {30065258},
  url     = {https://doi.org/10.1038/s41569-018-0064-2}
}

@article{irie2008-18195144,
  author  = {Irie, F. and Fitzpatrick, A. L. and Lopez, O. L. and Kuller, L. H. and Peila, R. and Newman, A. B. and Launer, L. J.},
  title   = {{Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneurol.2007.29},
  pmid    = {18195144},
  url     = {https://doi.org/10.1001/archneurol.2007.29}
}

@article{zlokovic2020-33030307,
  author  = {Zlokovic, B. V. and Gottesman, R. F. and Bernstein, K. E. and Seshadri, S. and McKee, A. and Snyder, H. and Greenberg, S. M. and Yaffe, K. and others},
  title   = {{Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12157},
  pmid    = {33030307},
  url     = {https://doi.org/10.1002/alz.12157}
}

@article{duara1986-3487046,
  author  = {Duara, R. and Grady, C. and Haxby, J. and Sundaram, M. and Cutler, N. R. and Heston, L. and Moore, A. and Schlageter, N. and others},
  title   = {{Positron emission tomography in Alzheimer's disease}},
  journal = {Neurology},
  year    = {1986},
  doi     = {10.1212/wnl.36.7.879},
  pmid    = {3487046},
  url     = {https://doi.org/10.1212/wnl.36.7.879}
}

@article{white2016-26888993,
  author  = {White, L. R. and Edland, S. D. and Hemmy, L. S. and Montine, K. S. and Zarow, C. and Sonnen, J. A. and Uyehara-Lock, J. H. and Gelber, R. P. and others},
  title   = {{Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000002480},
  pmid    = {26888993},
  url     = {https://doi.org/10.1212/wnl.0000000000002480}
}

@article{sudore2006-16881938,
  author  = {Sudore, R. L. and Yaffe, K. and Satterfield, S. and Harris, T. B. and Mehta, K. M. and Simonsick, E. M. and Newman, A. B. and Rosano, C. and others},
  title   = {{Limited literacy and mortality in the elderly: the health, aging, and body composition study}},
  journal = {Journal of general internal medicine},
  year    = {2006},
  doi     = {10.1111/j.1525-1497.2006.00539.x},
  pmid    = {16881938},
  url     = {https://doi.org/10.1111/j.1525-1497.2006.00539.x}
}

@article{sudore2006-16696742,
  author  = {Sudore, R. L. and Mehta, K. M. and Simonsick, E. M. and Harris, T. B. and Newman, A. B. and Satterfield, S. and Rosano, C. and others},
  title   = {{Limited literacy in older people and disparities in health and healthcare access}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2006},
  doi     = {10.1111/j.1532-5415.2006.00691.x},
  pmid    = {16696742},
  url     = {https://doi.org/10.1111/j.1532-5415.2006.00691.x}
}

@article{wolozin1996-8939861,
  author  = {Wolozin, B. and Iwasaki, K. and Vito, P. and Ganjei, J. K. and Lacanà, E. and Sunderland, T. and Zhao, B. and Kusiak, J. W. and others},
  title   = {{Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation}},
  journal = {Science (New York, N.Y.)},
  year    = {1996},
  doi     = {10.1126/science.274.5293.1710},
  pmid    = {8939861},
  url     = {https://doi.org/10.1126/science.274.5293.1710}
}

@article{geerlings2003-12730994,
  author  = {Geerlings, M. I. and Launer, L. J. and de Jong, F. H. and Ruitenberg, A. and Stijnen, T. and van Swieten, J. C. and Hofman, A. and Witteman, J. C. and others},
  title   = {{Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study}},
  journal = {Annals of neurology},
  year    = {2003},
  doi     = {10.1002/ana.10521},
  pmid    = {12730994},
  url     = {https://doi.org/10.1002/ana.10521}
}

@article{hsu2026-42060990,
  author  = {Hsu, Ying‐Hsin and Liang, Chih‐Kuang and Chou and Davidson, Jaysón and Wang, Y H and Nalls, Mike A. and Ferrucci, Luigi and Cookson, Mark and others},
  title   = {{Amyloid pathology and modifiable risk factors in cognitive decline among cognitively unimpaired older adults}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1016/j.tjpad.2026.100574},
  pmid    = {42060990},
  url     = {https://doi.org/10.1016/j.tjpad.2026.100574}
}

@article{tyas2003-12714116,
  author  = {Tyas, S. L. and White, L. R. and Petrovitch, H. and Webster Ross, G. and Foley, D. J. and Heimovitz, H. K. and Launer, L. J.},
  title   = {{Mid-life smoking and late-life dementia: the Honolulu-Asia Aging Study}},
  journal = {Neurobiology of aging},
  year    = {2003},
  doi     = {10.1016/s0197-4580(02)00156-2},
  pmid    = {12714116},
  url     = {https://doi.org/10.1016/s0197-4580(02)00156-2}
}

@article{laurin2004-15128608,
  author  = {Laurin, D. and Masaki, K. H. and Foley, D. J. and White, L. R. and Launer, L. J.},
  title   = {{Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study}},
  journal = {American journal of epidemiology},
  year    = {2004},
  doi     = {10.1093/aje/kwh124},
  pmid    = {15128608},
  url     = {https://doi.org/10.1093/aje/kwh124}
}

@article{wisniewski2003-14518801,
  author  = {Wisniewski, SR. and Belle, S. H. and Coon, D. W. and Marcus, S. M. and Ory, M. G. and Burgio, L. D. and Burns, R. and Schulz, R. and others},
  title   = {{The Resources for Enhancing Alzheimer's Caregiver Health (REACH): project design and baseline characteristics}},
  journal = {Psychology and aging},
  year    = {2003},
  doi     = {10.1037/0882-7974.18.3.375},
  pmid    = {14518801},
  url     = {https://doi.org/10.1037/0882-7974.18.3.375}
}

@article{kiecoltglaser2011-21148804,
  author  = {Kiecolt-Glaser, J. K. and Gouin, J. P. and Weng, N. P. and Malarkey, W. B. and Beversdorf, D. Q. and Glaser, R.},
  title   = {{Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation}},
  journal = {Psychosomatic medicine},
  year    = {2011},
  doi     = {10.1097/psy.0b013e31820573b6},
  pmid    = {21148804},
  url     = {https://doi.org/10.1097/psy.0b013e31820573b6}
}

@article{lesage2016-26942284,
  author  = {Lesage, S. and Drouet, V. and Majounie, E. and Deramecourt, V. and Jacoupy, M. and Nicolas, A. and Cormier-Dequaire, F. and Hassoun, S. M. and others},
  title   = {{Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy}},
  journal = {American journal of human genetics},
  year    = {2016},
  doi     = {10.1016/j.ajhg.2016.01.014},
  pmid    = {26942284},
  url     = {https://doi.org/10.1016/j.ajhg.2016.01.014}
}

@article{goetzl2016-27511944,
  author  = {Goetzl, E. J. and Mustapic, M. and Kapogiannis, D. and Eitan, E. and Lobach, IV. and Goetzl, L. and Schwartz, J. B. and Miller, B. L.},
  title   = {{Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2016},
  doi     = {10.1096/fj.201600756r},
  pmid    = {27511944},
  url     = {https://doi.org/10.1096/fj.201600756r}
}

@article{weissman2007-17704129,
  author  = {Weissman, L. and Jo, D. G. and Sørensen, M. M. and de Souza-Pinto, N. C. and Markesbery, W. R. and Mattson, M. P. and Bohr, V. A.},
  title   = {{Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment}},
  journal = {Nucleic acids research},
  year    = {2007},
  doi     = {10.1093/nar/gkm605},
  pmid    = {17704129},
  url     = {https://doi.org/10.1093/nar/gkm605}
}

@article{rezaizadeh2005-16177050,
  author  = {Rezai-Zadeh, K. and Shytle, D. and Sun, N. and Mori, T. and Hou, H. and Jeanniton, D. and Ehrhart, J. and Townsend, K. and others},
  title   = {{Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.1521-05.2005},
  pmid    = {16177050},
  url     = {https://doi.org/10.1523/jneurosci.1521-05.2005}
}

@article{huang2025-40624639,
  author  = {Huang, Tianyi and Beydoun, May A. and Kianersi, Sina and Redline, Susan S and Launer, Lenore J.},
  title   = {{Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank}},
  journal = {BMC Medicine},
  year    = {2025},
  doi     = {10.1186/s12916-025-04251-3},
  pmid    = {40624639},
  url     = {https://doi.org/10.1186/s12916-025-04251-3}
}

@article{caro2025-41266628,
  author  = {Caro, Ilana and Western, Daniel and Namba, Shinichi and Sun, Na and Kawaguchi, Shuji and He, Yunye and Fujita, Masashi and Roshchupkin, Gennady V. and others},
  title   = {{Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease}},
  journal = {Nature Aging},
  year    = {2025},
  doi     = {10.1038/s43587-025-01006-w},
  pmid    = {41266628},
  url     = {https://doi.org/10.1038/s43587-025-01006-w}
}

@article{bachman1993-8450993,
  author  = {Bachman, David and Wolf, Philip A. and Linn, Richard T. and Knoefel, Janice E. and Cobb, J. L. and Belanger, Albert J. and White, L. R. B. and D’Agostino, Ralph B.},
  title   = {{Incidence of dementia and probable Alzheimer's disease in a general population: the Framingham Study}},
  journal = {Neurology},
  year    = {1993},
  doi     = {10.1212/wnl.43.3_part_1.515},
  pmid    = {8450993},
  url     = {https://doi.org/10.1212/wnl.43.3_part_1.515}
}

@article{duggan2024-39143319,
  author  = {Duggan, M. R. and Peng, Z. and Sipilä, P. N. and Lindbohm, J. V. and Chen, J. and Lu, Y. and Davatzikos, C. and Erus, G. and others},
  title   = {{Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline}},
  journal = {Nature aging},
  year    = {2024},
  doi     = {10.1038/s43587-024-00682-4},
  pmid    = {39143319},
  url     = {https://doi.org/10.1038/s43587-024-00682-4}
}

@article{birdsill2013-23687103,
  author  = {Birdsill, A. C. and Carlsson, C. M. and Willette, A. A. and Okonkwo, O. C. and Johnson, S. C. and Xu, G. and Oh, J. M. and Gallagher, C. L. and others},
  title   = {{Low cerebral blood flow is associated with lower memory function in metabolic syndrome}},
  journal = {Obesity (Silver Spring, Md.)},
  year    = {2013},
  doi     = {10.1002/oby.20170},
  pmid    = {23687103},
  url     = {https://doi.org/10.1002/oby.20170}
}

@article{korf2004-15159381,
  author  = {Korf, E. S. and White, L. R. and Scheltens, P. and Launer, L. J.},
  title   = {{Midlife blood pressure and the risk of hippocampal atrophy: the Honolulu Asia Aging Study}},
  journal = {Hypertension (Dallas, Tex. : 1979)},
  year    = {2004},
  doi     = {10.1161/01.hyp.0000132475.32317.bb},
  pmid    = {15159381},
  url     = {https://doi.org/10.1161/01.hyp.0000132475.32317.bb}
}

@article{folego2020-33195111,
  author  = {Folego, G. and Weiler, M. and Casseb, R. F. and Pires, R. and Rocha, A.},
  title   = {{Alzheimer's Disease Detection Through Whole-Brain 3D-CNN MRI}},
  journal = {Frontiers in bioengineering and biotechnology},
  year    = {2020},
  doi     = {10.3389/fbioe.2020.534592},
  pmid    = {33195111},
  url     = {https://doi.org/10.3389/fbioe.2020.534592}
}

@article{greig2005-16275899,
  author  = {Greig, N. H. and Utsuki, T. and Ingram, D. K. and Wang, Y. and Pepeu, G. and Scali, C. and Yu, Q. S. and Mamczarz, J. and others},
  title   = {{Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0508575102},
  pmid    = {16275899},
  url     = {https://doi.org/10.1073/pnas.0508575102}
}

@article{white2002-12480729,
  author  = {White, L. and Petrovitch, H. and Hardman, J. and Nelson, J. and Davis, D. G. and Ross, G. W. and Masaki, K. and Launer, L. and others},
  title   = {{Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2002},
  doi     = {10.1111/j.1749-6632.2002.tb04794.x},
  pmid    = {12480729},
  url     = {https://doi.org/10.1111/j.1749-6632.2002.tb04794.x}
}

@article{beydoun2025-40588577,
  author  = {Beydoun, May A. and Hu, Yi‐Han and Li, Zhiguang and Georgescu, Michael F. and Beydoun, Hind A. and Hooten, Nicole Noren and Walker, Keenan A. and Bouhrara, Mustapha and others},
  title   = {{Alzheimer’s disease polygenic risk’s association with all-cause dementia through the plasma metabolome in the UK Biobank study}},
  journal = {GeroScience},
  year    = {2025},
  doi     = {10.1007/s11357-025-01724-4},
  pmid    = {40588577},
  url     = {https://doi.org/10.1007/s11357-025-01724-4}
}

@article{teng1994-8054493,
  author  = {Teng, Evelyn Lee and Hasegawa, Kazuo and Homma, Akira and Imai, Yukimuchi and Larson, Eric B. and Graves, Amy Borenstein and Sugimoto, Keiko and Yamaguchi, Takenori and Sasaki, Hideo and Chiu, Darryl and White, Lon R.},
  title   = {{The Cognitive Abilities Screening Instrument (CASI): A Practical Test for Cross-Cultural Epidemiological Studies of Dementia}},
  journal = {International Psychogeriatrics},
  year    = {1994},
  doi     = {10.1017/s1041610294001602},
  pmid    = {8054493},
  url     = {https://doi.org/10.1017/s1041610294001602}
}

@article{thomassen2026-42736378,
  author  = {Thomassen, J. Q. and Leonard, H. and Ulms, B. and Grenier-Boley, B. and Heikkinen, S. and Garcia-González, P. and Castillo-Morales, A. and Kikuchi, M. and Gim, J. and Cao, H. and Küçükali, F. and Amin, N. and others},
  title   = {{APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease}},
  journal = {Nature genetics},
  year    = {2026},
  doi     = {10.1038/s41588-026-02713-9},
  pmid    = {42736378},
  url     = {https://doi.org/10.1038/s41588-026-02713-9}
}

@article{denheijer2005-15668423,
  author  = {den Heijer, T. and Launer, L. J. and Prins, N. D. and van Dijk, E. J. and Vermeer, S. E. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.},
  title   = {{Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000149641.55751.2e},
  pmid    = {15668423},
  url     = {https://doi.org/10.1212/01.wnl.0000149641.55751.2e}
}

@article{varatharajah2019-30783207,
  author  = {Varatharajah, Y. and Ramanan, V. K. and Iyer, R. and Vemuri, P. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-38793-3},
  pmid    = {30783207},
  url     = {https://doi.org/10.1038/s41598-019-38793-3}
}

@article{tweedie2012-22642825,
  author  = {Tweedie, D. and Ferguson, R. A. and Fishman, K. and Frankola, K. A. and Van Praag, H. and Holloway, H. W. and Luo, W. and Li, Y. and others},
  title   = {{Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2012},
  doi     = {10.1186/1742-2094-9-106},
  pmid    = {22642825},
  url     = {https://doi.org/10.1186/1742-2094-9-106}
}

@article{saezatienzar2020-32601397,
  author  = {Saez-Atienzar, S. and Masliah, E.},
  title   = {{Cellular senescence and Alzheimer disease: the egg and the chicken scenario}},
  journal = {Nature reviews. Neuroscience},
  year    = {2020},
  doi     = {10.1038/s41583-020-0325-z},
  pmid    = {32601397},
  url     = {https://doi.org/10.1038/s41583-020-0325-z}
}

@article{bouhrara2018-29679574,
  author  = {Bouhrara, M. and Reiter, D. A. and Bergeron, C. M. and Zukley, L. M. and Ferrucci, L. and Resnick, S. M. and Spencer, R. G.},
  title   = {{Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2018},
  doi     = {10.1016/j.jalz.2018.03.007},
  pmid    = {29679574},
  url     = {https://doi.org/10.1016/j.jalz.2018.03.007}
}

@article{pulliam2019-30610738,
  author  = {Pulliam, L. and Sun, B. and Mustapic, M. and Chawla, S. and Kapogiannis, D.},
  title   = {{Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease}},
  journal = {Journal of neurovirology},
  year    = {2019},
  doi     = {10.1007/s13365-018-0695-4},
  pmid    = {30610738},
  url     = {https://doi.org/10.1007/s13365-018-0695-4}
}

@article{domenichiello2019-31004724,
  author  = {Domenichiello, A. F. and Ramsden, C. E.},
  title   = {{The silent epidemic of chronic pain in older adults}},
  journal = {Progress in neuro-psychopharmacology \& biological psychiatry},
  year    = {2019},
  doi     = {10.1016/j.pnpbp.2019.04.006},
  pmid    = {31004724},
  url     = {https://doi.org/10.1016/j.pnpbp.2019.04.006}
}

@article{herskowitz2013-24305806,
  author  = {Herskowitz, J. H. and Feng, Y. and Mattheyses, A. L. and Hales, C. M. and Higginbotham, L. A. and Duong, D. M. and Montine, T. J. and Troncoso, J. C. and others},
  title   = {{Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2013},
  doi     = {10.1523/jneurosci.2508-13.2013},
  pmid    = {24305806},
  url     = {https://doi.org/10.1523/jneurosci.2508-13.2013}
}

@article{alvarado2024-38181731,
  author  = {Alvarado, C. X. and Makarious, M. B. and Weller, C. A. and Vitale, D. and Koretsky, M. J. and Bandres-Ciga, S. and Iwaki, H. and Levine, K. and others},
  title   = {{omicSynth: An open multi-omic community resource for identifying druggable targets across neurodegenerative diseases}},
  journal = {American journal of human genetics},
  year    = {2024},
  doi     = {10.1016/j.ajhg.2023.12.006},
  pmid    = {38181731},
  url     = {https://doi.org/10.1016/j.ajhg.2023.12.006}
}

@article{gu2010-20409326,
  author  = {Gu, X. L. and Long, C. X. and Sun, L. and Xie, C. and Lin, X. and Cai, H.},
  title   = {{Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice}},
  journal = {Molecular brain},
  year    = {2010},
  doi     = {10.1186/1756-6606-3-12},
  pmid    = {20409326},
  url     = {https://doi.org/10.1186/1756-6606-3-12}
}

@article{acostauribe2026-41586258,
  author  = {Acosta‐Uribe, Juliana and Piña‐Escudero, Stefanie Danielle and Cochran, J. Nicholas and Taylor, Jared W. and Castruita, P. Alejandra and Jonson, Caroline and Barinaga, Erin A. and Roberts, Kevin and others},
  title   = {{Genetic contributions to Alzheimer’s disease and frontotemporal dementia in admixed Latin American populations}},
  journal = {npj Dementia},
  year    = {2026},
  doi     = {10.1038/s44400-025-00025-z},
  pmid    = {41586258},
  url     = {https://doi.org/10.1038/s44400-025-00025-z}
}

@article{hsu2025-41268047,
  author  = {Hsu, Ying‐Hsin and Liang, Chih‐Kuang and Chou, Ming-Yueh and Shen, Hsiu‐Chu and Wang, Yu‐Chun and Iwaki, Hirotaka and Lin, Yu‐Te and Fann, Yang Cheng},
  title   = {{Polypharmacy and risk of dementia progression in older adults with mild cognitive impairment: A longitudinal cohort study}},
  journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
  year    = {2025},
  doi     = {10.1002/trc2.70179},
  pmid    = {41268047},
  url     = {https://doi.org/10.1002/trc2.70179}
}

@article{wong2018-29728519,
  author  = {Wong, D. F. and Comley, R. A. and Kuwabara, H. and Rosenberg, P. B. and Resnick, S. M. and Ostrowitzki, S. and Vozzi, C. and Boess, F. and others},
  title   = {{Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2018},
  doi     = {10.2967/jnumed.118.209916},
  pmid    = {29728519},
  url     = {https://doi.org/10.2967/jnumed.118.209916}
}

@article{yaffe2007-17097195,
  author  = {Yaffe, K. and Barnes, D. and Lindquist, K. and Cauley, J. and Simonsick, E. M. and Penninx, B. and Satterfield, S. and Harris, T. and others},
  title   = {{Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort}},
  journal = {Neurobiology of aging},
  year    = {2007},
  doi     = {10.1016/j.neurobiolaging.2006.10.004},
  pmid    = {17097195},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2006.10.004}
}

@article{ferrucci1996-8909348,
  author  = {Ferrucci, L. and Cecchi, F. and Guralnik, J. M. and Giampaoli, S. and Lo Noce, C. and Salani, B. and Bandinelli, S. and others},
  title   = {{Does the Clock Drawing Test predict cognitive decline in older persons independent of the Mini-Mental State Examination? The FINE Study Group. Finland, Italy, The Netherlands Elderly}},
  journal = {Journal of the American Geriatrics Society},
  year    = {1996},
  doi     = {10.1111/j.1532-5415.1996.tb01403.x},
  pmid    = {8909348},
  url     = {https://doi.org/10.1111/j.1532-5415.1996.tb01403.x}
}

@article{ottoy2025-40922096,
  author  = {Ottoy, Julie and Owsicki, Nicole and Bilgel, Murat and Binette, Alexa Pichet and Salvadó, Gemma and Kang, Min Su and Cash, David M. and Ewers, Michael and others},
  title   = {{Recent advances in neuroimaging of Alzheimer's disease and related dementias}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70648},
  pmid    = {40922096},
  url     = {https://doi.org/10.1002/alz.70648}
}

@article{idda2018-29327503,
  author  = {Idda, M. L. and Munk, R. and Abdelmohsen, K. and Gorospe, M.},
  title   = {{Noncoding RNAs in Alzheimer's disease}},
  journal = {Wiley interdisciplinary reviews. RNA},
  year    = {2018},
  doi     = {10.1002/wrna.1463},
  pmid    = {29327503},
  url     = {https://doi.org/10.1002/wrna.1463}
}

@article{friedland1988-2969203,
  author  = {Friedland, R. P. and Koss, E. and Haxby, J. V. and Grady, C. L. and Luxenberg, J. and Schapiro, M. B. and Kaye, J.},
  title   = {{NIH conference. Alzheimer disease: clinical and biological heterogeneity}},
  journal = {Annals of internal medicine},
  year    = {1988},
  doi     = {10.7326/0003-4819-109-4-298},
  pmid    = {2969203},
  url     = {https://doi.org/10.7326/0003-4819-109-4-298}
}

@article{savonenko2005-15755686,
  author  = {Savonenko, A. and Xu, G. M. and Melnikova, T. and Morton, J. L. and Gonzales, V. and Wong, M. P. and Price, D. L. and Tang, F. and others},
  title   = {{Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2004.10.022},
  pmid    = {15755686},
  url     = {https://doi.org/10.1016/j.nbd.2004.10.022}
}

@article{keller2025-40194370,
  author  = {Keller, Jasmin Annica and Sigurdsson, Sigurdur Oli and Launer, Lenore J. and van Buchem, Mark A. and van Osch, Matthias J.P. and Gudnason, Vilmundur G. and de Bresser, Jeroen},
  title   = {{A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults}},
  journal = {Neurobiology of Aging},
  year    = {2025},
  doi     = {10.1016/j.neurobiolaging.2025.03.011},
  pmid    = {40194370},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2025.03.011}
}

@article{henderson2016-27246255,
  author  = {Henderson, B. W. and Gentry, E. G. and Rush, T. and Troncoso, J. C. and Thambisetty, M. and Montine, T. J. and Herskowitz, J. H.},
  title   = {{Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain}},
  journal = {Journal of neurochemistry},
  year    = {2016},
  doi     = {10.1111/jnc.13688},
  pmid    = {27246255},
  url     = {https://doi.org/10.1111/jnc.13688}
}

@article{hou2017-27105872,
  author  = {Hou, Y. and Song, H. and Croteau, D. L. and Akbari, M. and Bohr, V. A.},
  title   = {{Genome instability in Alzheimer disease}},
  journal = {Mechanisms of ageing and development},
  year    = {2017},
  doi     = {10.1016/j.mad.2016.04.005},
  pmid    = {27105872},
  url     = {https://doi.org/10.1016/j.mad.2016.04.005}
}

@article{king2025-41732983,
  author  = {King, Jonathan W and Chatterji, Minki},
  title   = {{NIA perspective on harmonizing International Health and Retirement Studies (HRS) and Harmonized Cognitive Assessment Protocol (HCAP) studies}},
  journal = {The Journals of Gerontology Series B},
  year    = {2025},
  doi     = {10.1093/geronb/gbaf260},
  pmid    = {41732983},
  url     = {https://doi.org/10.1093/geronb/gbaf260}
}

@article{shamrok2025-41434629,
  author  = {Shamrok, Hanadi and Davidy, Tal and Yore, Iscka and Niv, Tal and Yaffe, Tali C and Ravona‐Springer, Ramit and Livny, Abigail and Lesman‐Segev, Orit H. and others},
  title   = {{Combination of Intranasal insulin and oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_102127},
  pmid    = {41434629},
  url     = {https://doi.org/10.1002/alz70860_102127}
}

@article{vasconcelos2014-24886300,
  author  = {Vasconcelos, A. R. and Yshii, L. M. and Viel, T. A. and Buck, H. S. and Mattson, M. P. and Scavone, C. and Kawamoto, E. M.},
  title   = {{Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment}},
  journal = {Journal of neuroinflammation},
  year    = {2014},
  doi     = {10.1186/1742-2094-11-85},
  pmid    = {24886300},
  url     = {https://doi.org/10.1186/1742-2094-11-85}
}

@article{murphy1993-8292690,
  author  = {Murphy, D. G. and DeCarli, C. D. and Daly, E. and Gillette, J. A. and McIntosh, A. R. and Haxby, J. V. and Teichberg, D. and Schapiro, M. B. and others},
  title   = {{Volumetric magnetic resonance imaging in men with dementia of the Alzheimer type: correlations with disease severity}},
  journal = {Biological psychiatry},
  year    = {1993},
  doi     = {10.1016/0006-3223(93)90153-5},
  pmid    = {8292690},
  url     = {https://doi.org/10.1016/0006-3223(93)90153-5}
}

@article{marutle2007-17640880,
  author  = {Marutle, A. and Ohmitsu, M. and Nilbratt, M. and Greig, N. H. and Nordberg, A. and Sugaya, K.},
  title   = {{Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2007},
  doi     = {10.1073/pnas.0705346104},
  pmid    = {17640880},
  url     = {https://doi.org/10.1073/pnas.0705346104}
}

@article{schubert2023-37698523,
  author  = {Schubert, C. R. and Paulsen, A. J. and Pinto, A. A. and Chappell, R. J. and Chen, Y. and Ferrucci, L. and Hancock, L. M. and Cruickshanks, K. J. and others},
  title   = {{Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2023},
  doi     = {10.1097/wad.0000000000000579},
  pmid    = {37698523},
  url     = {https://doi.org/10.1097/wad.0000000000000579}
}

@article{knopman2026-41843859,
  author  = {Knopman, D. S. and Pike, JR. and Griswold, M. and Lu, Y. and Gross, A. and Mosley, T. H. and Windham, B. G. and Albert, M. S. and others},
  title   = {{Contingency of Plasma Dementia Biomarkers on Cognitive Profiles for Prognosis of Incident Dementia: The ARIC Study}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000214779},
  pmid    = {41843859},
  url     = {https://doi.org/10.1212/wnl.0000000000214779}
}

@article{igarashi2011-21297269,
  author  = {Igarashi, M. and Ma, K. and Gao, F. and Kim, H. W. and Rapoport, S. I. and Rao, J. S.},
  title   = {{Disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2011},
  doi     = {10.3233/jad-2011-101608},
  pmid    = {21297269},
  url     = {https://doi.org/10.3233/jad-2011-101608}
}

@article{tweedie2007-17908040,
  author  = {Tweedie, D. and Sambamurti, K. and Greig, N. H.},
  title   = {{TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets}},
  journal = {Current Alzheimer research},
  year    = {2007},
  doi     = {10.2174/156720507781788873},
  pmid    = {17908040},
  url     = {https://doi.org/10.2174/156720507781788873}
}

@article{barsoum2025-40585810,
  author  = {Barsoum, Stephanie and Latimer, Caitlin S. and Nolan, Amber and Barrett, Alexander S. and Chang, Koping and Troncoso, Juan Carlos and Keene, Christopher Dirk and Benjamini, Dan},
  title   = {{Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer’s disease}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf245},
  pmid    = {40585810},
  url     = {https://doi.org/10.1093/braincomms/fcaf245}
}

@article{murphy2000-10837793,
  author  = {Murphy, E. J. and Schapiro, M. B. and Rapoport, S. I. and Shetty, H. U.},
  title   = {{Phospholipid composition and levels are altered in Down syndrome brain}},
  journal = {Brain research},
  year    = {2000},
  doi     = {10.1016/s0006-8993(00)02205-8},
  pmid    = {10837793},
  url     = {https://doi.org/10.1016/s0006-8993(00)02205-8}
}

@article{schapiro1990-2137464,
  author  = {Schapiro, M. B. and Grady, C. L. and Kumar, A. and Herscovitch, P. and Haxby, J. V. and Moore, A. M. and White, B. and Friedland, R. P. and others},
  title   = {{Regional cerebral glucose metabolism is normal in young adults with Down syndrome}},
  journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year    = {1990},
  doi     = {10.1038/jcbfm.1990.35},
  pmid    = {2137464},
  url     = {https://doi.org/10.1038/jcbfm.1990.35}
}

@article{mouton2009-19699265,
  author  = {Mouton, P. R. and Chachich, M. E. and Quigley, C. and Spangler, E. and Ingram, D. K.},
  title   = {{Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice}},
  journal = {Neuroscience letters},
  year    = {2009},
  doi     = {10.1016/j.neulet.2009.08.038},
  pmid    = {19699265},
  url     = {https://doi.org/10.1016/j.neulet.2009.08.038}
}

@article{becker2008-18953116,
  author  = {Becker, R. E. and Greig, N. H. and Giacobini, E.},
  title   = {{Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2008},
  doi     = {10.3233/jad-2008-15213},
  pmid    = {18953116},
  url     = {https://doi.org/10.3233/jad-2008-15213}
}

@article{nath2003-12665674,
  author  = {Nath, A. and Hall, E. and Tuzova, M. and Dobbs, M. and Jons, M. and Anderson, C. and Woodward, J. and Guo, Z. and others},
  title   = {{Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development}},
  journal = {Neuromolecular medicine},
  year    = {2003},
  doi     = {10.1385/nmm:3:1:29},
  pmid    = {12665674},
  url     = {https://doi.org/10.1385/nmm:3:1:29}
}

@article{guo2025-40949843,
  author  = {Guo, Alexander Y. and Laporte, John P and Singh, Kavita and Bae, Jonghyun and Bergeron, Keagan and Rouen, Alexandre and Fox, Noam and Zhang, Nathan and others},
  title   = {{Machine learning diagnosis of mild cognitive impairment using advanced diffusion MRI and CSF biomarkers}},
  journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
  year    = {2025},
  doi     = {10.1002/dad2.70182},
  pmid    = {40949843},
  url     = {https://doi.org/10.1002/dad2.70182}
}

@article{zuckerman2008-18818454,
  author  = {Zuckerman, I. H. and Ryder, P. T. and Simoni-Wastila, L. and Shaffer, T. and Sato, M. and Zhao, L. and Stuart, B.},
  title   = {{Racial and ethnic disparities in the treatment of dementia among Medicare beneficiaries}},
  journal = {The journals of gerontology. Series B, Psychological sciences and social sciences},
  year    = {2008},
  doi     = {10.1093/geronb/63.5.s328},
  pmid    = {18818454},
  url     = {https://doi.org/10.1093/geronb/63.5.s328}
}

@article{stoeckel2025-39975465,
  author  = {Stoeckel, Luke E. and Fazio, Elena M. and Hardy, Kristina K. and Kidwiler, Nicole and McLinden, Kristina A. and Williams, Benfeard},
  title   = {{Clinically meaningful outcomes in Alzheimer's disease and Alzheimer's disease related dementias trials}},
  journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
  year    = {2025},
  doi     = {10.1002/trc2.70058},
  pmid    = {39975465},
  url     = {https://doi.org/10.1002/trc2.70058}
}

@article{nelson1997-9356503,
  author  = {Nelson, P. G. and Fitzgerald, S. and Rapoport, S. I. and Neale, E. A. and Galdzicki, Z. and Dunlap, V. and Bowers, L. and v Agoston, D.},
  title   = {{Cerebral cortical astroglia from the trisomy 16 mouse, a model for down syndrome, produce neuronal cholinergic deficits in cell culture}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.23.12644},
  pmid    = {9356503},
  url     = {https://doi.org/10.1073/pnas.94.23.12644}
}

@article{rapoport1989-2528670,
  author  = {Rapoport, S. I.},
  title   = {{Hypothesis: Alzheimer's disease is a phylogenetic disease}},
  journal = {Medical hypotheses},
  year    = {1989},
  doi     = {10.1016/0306-9877(89)90185-0},
  pmid    = {2528670},
  url     = {https://doi.org/10.1016/0306-9877(89)90185-0}
}

@article{rapoport1996-8863135,
  author  = {Rapoport, S. I.},
  title   = {{Modulation of blood-brain barrier permeability}},
  journal = {Journal of drug targeting},
  year    = {1996},
  doi     = {10.3109/10611869609015962},
  pmid    = {8863135},
  url     = {https://doi.org/10.3109/10611869609015962}
}

@article{sanford1993-8221609,
  author  = {Sanford, K. K. and Parshad, R. and Price, F. M. and Tarone, R. E. and Schapiro, M. B.},
  title   = {{X-ray-induced chromatid damage in cells from Down syndrome and Alzheimer disease patients in relation to DNA repair and cancer proneness}},
  journal = {Cancer genetics and cytogenetics},
  year    = {1993},
  doi     = {10.1016/0165-4608(93)90127-8},
  pmid    = {8221609},
  url     = {https://doi.org/10.1016/0165-4608(93)90127-8}
}

@article{grady1989-2919988,
  author  = {Grady, C. L. and Grimes, A. M. and Patronas, N. and Sunderland, T. and Foster, N. L. and Rapoport, S. I.},
  title   = {{Divided attention, as measured by dichotic speech performance, in dementia of the Alzheimer type}},
  journal = {Archives of neurology},
  year    = {1989},
  doi     = {10.1001/archneur.1989.00520390083021},
  pmid    = {2919988},
  url     = {https://doi.org/10.1001/archneur.1989.00520390083021}
}

@article{luxenberg1988-2973233,
  author  = {Luxenberg, J. S. and Plato, C. C. and Fox, K. M. and Friedland, R. P. and Rapoport, S. I.},
  title   = {{Digital and palmar dermatoglyphics in dementia of the Alzheimer type}},
  journal = {American journal of medical genetics},
  year    = {1988},
  doi     = {10.1002/ajmg.1320300306},
  pmid    = {2973233},
  url     = {https://doi.org/10.1002/ajmg.1320300306}
}

@article{williams1985-3973333,
  author  = {Williams, T. Franklin},
  title   = {{A Perspective on Training for Academic Leadership in Geriatrics*}},
  journal = {Journal of the American Geriatrics Society},
  year    = {1985},
  doi     = {10.1111/j.1532-5415.1985.tb04885.x},
  pmid    = {3973333},
  url     = {https://doi.org/10.1111/j.1532-5415.1985.tb04885.x}
}

@article{steel2006-16866689,
  author  = {Steel, Knight and Williams, T. Franklin},
  title   = {{It's Time to March}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2006},
  doi     = {10.1111/j.1532-5415.2006.00792.x},
  pmid    = {16866689},
  url     = {https://doi.org/10.1111/j.1532-5415.2006.00792.x}
}

@article{shin2026-a566b431,
  author  = {Shin, J. H. and Perinan, M. T. and Jang, J. W. and Screven, L. and Lange, L. M. and Klein, C. and Shulman, J. M. and Gan-Or and others},
  title   = {{GCH1 genetic variation as a prognostic factor in Parkinsons disease across populations}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.14.26359677},
  url     = {https://doi.org/10.64898/2026.08.14.26359677}
}

@article{bilgel2026-7bb89a73,
  author  = {Bilgel, M. and Shah, I. and Cooper, J. and An, Y. and Walker, K. A. and Ho, S. G. and Moghekar, A. R. and Yang and others},
  title   = {{Association of plasma biomarkers with longitudinal change in age- and Alzheimer's disease-related brain atrophy patterns}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.11.26362869},
  url     = {https://doi.org/10.64898/2026.09.11.26362869}
}

@article{paolillo2026-7ef6cdb9,
  author  = {Paolillo, E. W. and Dhanam, S. and Taylor, J. C. and Sanderson-Cimino, M. and Fregly, R. and Saloner, R. and Casaletto, K. B. and Kramer and others},
  title   = {{Smartphone Passive Digital Phenotyping in Frontotemporal Lobar Degeneration}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.18.26363439},
  url     = {https://doi.org/10.64898/2026.09.18.26363439}
}