% alzhub.org library filter % Source: https://alzhub.org/research?institution=I4210123851 % 170 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{warmenhoven2025-39468767, author = {Warmenhoven, N. and Salvadó, G. and Janelidze, S. and Mattsson-Carlgren, N. and Bali, D. and Orduña Dolado, A. and Kolb, H. and Triana-Baltzer, G. and Barthélemy, N. R. and Schindler, S. E. and Aschenbrenner, A. J. and Raji, C. A. and others}, title = {{A comprehensive head-to-head comparison of key plasma phosphorylated tau 217 biomarker tests}}, journal = {Brain}, year = {2025}, doi = {10.1093/brain/awae346}, pmid = {39468767}, url = {https://doi.org/10.1093/brain/awae346} } @article{gordon2018-29397305, author = {Gordon, B. A. and Blazey, T. M. and Su, Y. and Hari-Raj, A. and Dincer, A. and Flores, S. and Christensen, J. and McDade, E. and others}, title = {{Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(18)30028-0}, pmid = {29397305}, url = {https://doi.org/10.1016/s1474-4422(18)30028-0} } @article{janelidze2024-39068669, author = {Janelidze, S. and Barthélemy, N. R. and Salvadó, G. and Schindler, S. E. and Palmqvist, S. and Mattsson-Carlgren, N. and Braunstein, J. B. and Ovod, V. and Bollinger, J. G. and He, Y. and Li, Y. and Raji, C. A. and others}, title = {{Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment}}, journal = {JAMA Neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.2619}, pmid = {39068669}, url = {https://doi.org/10.1001/jamaneurol.2024.2619} } @article{xu2025-40067298, author = {Xu, X. and Kwon, J. and Yan, R. and Apio, C. and Song, S. and Heo, G. and Yang, Q. and Timsina, J. and others}, title = {{Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries}}, journal = {JAMA network open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.0562}, pmid = {40067298}, url = {https://doi.org/10.1001/jamanetworkopen.2025.0562} } @article{jansen2022-36066633, author = {Jansen, I. E. and van der Lee, S. J. and Gomez-Fonseca, D. and de Rojas, I. and Dalmasso, M. C. and Grenier-Boley, B. and Zettergren, A. and Mishra, A. and others}, title = {{Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers}}, journal = {Acta neuropathologica}, year = {2022}, doi = {10.1007/s00401-022-02454-z}, pmid = {36066633}, url = {https://doi.org/10.1007/s00401-022-02454-z} } @article{mattssoncarlgren2026-41864233, author = {Mattsson-Carlgren, Niklas and Palmqvist, Sebastian and Horie, Kanta and Barthélemy, Nicolas and Salvadó, Gemma and Binette, Alexa Pichet and Tideman, Pontus and Morris, John C and others}, title = {{Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study}}, journal = {The Lancet. Neurology}, year = {2026}, doi = {10.1016/S1474-4422(26)00029-3}, pmid = {41864233}, url = {https://doi.org/10.1016/S1474-4422(26)00029-3} } @article{parhizkar2019-30617257, author = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others}, title = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-018-0296-9}, pmid = {30617257}, url = {https://doi.org/10.1038/s41593-018-0296-9} } @article{petersen2026-41714746, author = {Petersen, Kellen K and Milà-Alomà, Marta and Li, Yan and Du, Lianlian and Xiong, Chengjie and Tosun, Duygu and Saef, Benjamin and Saad, Ziad S and others}, title = {{Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks}}, journal = {Nature medicine}, year = {2026}, doi = {10.1038/s41591-026-04206-y}, pmid = {41714746}, url = {https://doi.org/10.1038/s41591-026-04206-y} } @article{piccio2016-26754641, author = {Piccio, L. and Deming, Y. and Del-Águila, J. L. and Ghezzi, L. and Holtzman, D. M. and Fagan, A. M. and Fenoglio, C. and Galimberti, D. and others}, title = {{Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-016-1533-5}, pmid = {26754641}, url = {https://doi.org/10.1007/s00401-016-1533-5} } @article{suarezcalvet2019-30630532, author = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others}, title = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-018-0301-5}, pmid = {30630532}, url = {https://doi.org/10.1186/s13024-018-0301-5} } @article{benitez2014-24439484, author = {Benitez, B. A. and Jin, S. C. and Guerreiro, R. and Graham, R. and Lord, J. and Harold, D. and Sims, R. and Lambert, J. C. and others}, title = {{Missense variant in TREML2 protects against Alzheimer's disease}}, journal = {Neurobiology of aging}, year = {2014}, doi = {10.1016/j.neurobiolaging.2013.12.010}, pmid = {24439484}, url = {https://doi.org/10.1016/j.neurobiolaging.2013.12.010} } @article{salvado2026-42189519, author = {Salvadó, G. and Horie, K. and Barthélemy, N. R. and Schindler, S. E. and Janelidze, S. and Orduña Dolado, A. and Bali, D. and Perrin, R. J. and Morris, J. C. and Benzinger, T. L. S. and Gordon, B. A. and Stomrud, E. and others}, title = {{Plasma eMTBR-tau243 and \%p-tau217 for Biological Staging of Alzheimer Disease}}, journal = {JAMA Neurology}, year = {2026}, doi = {10.1001/jamaneurol.2026.1405}, pmid = {42189519}, url = {https://doi.org/10.1001/jamaneurol.2026.1405} } @article{holstege2022-36411364, author = {Holstege, H. and Hulsman, M. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Grozeva, D. and van Rooij, J. G. J. and Sims, R. and others}, title = {{Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease}}, journal = {Nature genetics}, year = {2022}, doi = {10.1038/s41588-022-01208-7}, pmid = {36411364}, url = {https://doi.org/10.1038/s41588-022-01208-7} } @article{horie2023-37443334, author = {Horie, K. and Salvadó, G. and Barthélemy, N. R. and Janelidze, S. and Li, Y. and He, Y. and Saef, B. and Chen, C. D. and others}, title = {{CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer's disease}}, journal = {Nature medicine}, year = {2023}, doi = {10.1038/s41591-023-02443-z}, pmid = {37443334}, url = {https://doi.org/10.1038/s41591-023-02443-z} } @article{li2022-34906975, author = {Li, Y. and Schindler, S. E. and Bollinger, J. G. and Ovod, V. and Mawuenyega, K. G. and Weiner, M. W. and Shaw, L. M. and Masters, C. L. and others}, title = {{Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000013211}, pmid = {34906975}, url = {https://doi.org/10.1212/wnl.0000000000013211} } @article{wisch2024-38631766, author = {Wisch, J. K. and McKay, N. S. and Boerwinkle, A. H. and Kennedy, J. and Flores, S. and Handen, B. L. and Christian, B. T. and Head, E. and others}, title = {{Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2024}, doi = {10.1016/s1474-4422(24)00084-x}, pmid = {38631766}, url = {https://doi.org/10.1016/s1474-4422(24)00084-x} } @article{ju2013-23479184, author = {Ju, Y. E. and McLeland, J. S. and Toedebusch, C. D. and Xiong, C. and Fagan, A. M. and Duntley, S. P. and Morris, J. C. and Holtzman, D. M.}, title = {{Sleep quality and preclinical Alzheimer disease}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.2334}, pmid = {23479184}, url = {https://doi.org/10.1001/jamaneurol.2013.2334} } @article{horie2025-40164726, author = {Horie, Kanta and Salvadó, Gemma and Koppisetti, Rama K. and Janelidze, Shorena and Barthélemy, Nicolas R. and He, Yingxin and Sato, Chihiro and Gordon, Brian Andrew and others}, title = {{Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease}}, journal = {Nature Medicine}, year = {2025}, doi = {10.1038/s41591-025-03617-7}, pmid = {40164726}, url = {https://doi.org/10.1038/s41591-025-03617-7} } @article{zhou2020-31932797, author = {Zhou, Y. and Song, W. M. and Andhey, P. S. and Swain, A. and Levy, T. and Miller, K. R. and Poliani, P. L. and Cominelli, M. and others}, title = {{Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease}}, journal = {Nature medicine}, year = {2020}, doi = {10.1038/s41591-019-0695-9}, pmid = {31932797}, url = {https://doi.org/10.1038/s41591-019-0695-9} } @article{shi2017-28959956, author = {Shi, Y. and Yamada, K. and Liddelow, S. A. and Smith, S. T. and Zhao, L. and Luo, W. and Tsai, R. M. and Spina, S. and others}, title = {{ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature24016}, pmid = {28959956}, url = {https://doi.org/10.1038/nature24016} } @article{lucey2021-34668959, author = {Lucey, B. P. and Wisch, J. and Boerwinkle, A. H. and Landsness, E. C. and Toedebusch, C. D. and McLeland, J. S. and Butt, O. H. and Hassenstab, J. and others}, title = {{Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2021}, doi = {10.1093/brain/awab272}, pmid = {34668959}, url = {https://doi.org/10.1093/brain/awab272} } @article{self2023-37667136, author = {Self, W. K. and Holtzman, D. M.}, title = {{Emerging diagnostics and therapeutics for Alzheimer disease}}, journal = {Nature medicine}, year = {2023}, doi = {10.1038/s41591-023-02505-2}, pmid = {37667136}, url = {https://doi.org/10.1038/s41591-023-02505-2} } @article{kester2015-26366630, author = {Kester, M. I. and Teunissen, C. E. and Crimmins, D. L. and Herries, E. M. and Ladenson, J. H. and Scheltens, P. and van der Flier, W. M. and Morris, J. C. and others}, title = {{Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2015.1867}, pmid = {26366630}, url = {https://doi.org/10.1001/jamaneurol.2015.1867} } @article{roe2013-23576620, author = {Roe, C. M. and Fagan, A. M. and Grant, E. A. and Hassenstab, J. and Moulder, K. L. and Maue Dreyfus, D. and Sutphen, C. L. and Benzinger, T. L. and others}, title = {{Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later}}, journal = {Neurology}, year = {2013}, doi = {10.1212/wnl.0b013e3182918ca6}, pmid = {23576620}, url = {https://doi.org/10.1212/wnl.0b013e3182918ca6} } @article{vlassenko2016-27398953, author = {Vlassenko, A. G. and McCue, L. and Jasielec, M. S. and Su, Y. and Gordon, B. A. and Xiong, C. and Holtzman, D. M. and Benzinger, T. L. and others}, title = {{Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease}}, journal = {Annals of neurology}, year = {2016}, doi = {10.1002/ana.24719}, pmid = {27398953}, url = {https://doi.org/10.1002/ana.24719} } @article{gordon2016-27548756, author = {Gordon, B. A. and Blazey, T. and Su, Y. and Fagan, A. M. and Holtzman, D. M. and Morris, J. C. and Benzinger, T. L.}, title = {{Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.2642}, pmid = {27548756}, url = {https://doi.org/10.1001/jamaneurol.2016.2642} } @article{llibreguerra2019-31825500, author = {Llibre-Guerra, J. J. and Li, Y. and Schindler, S. E. and Gordon, B. A. and Fagan, A. M. and Morris, J. C. and Benzinger, T. L. S. and Hassenstab, J. and others}, title = {{Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.17126}, pmid = {31825500}, url = {https://doi.org/10.1001/jamanetworkopen.2019.17126} } @article{krasemann2017-28930663, author = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others}, title = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}}, journal = {Immunity}, year = {2017}, doi = {10.1016/j.immuni.2017.08.008}, pmid = {28930663}, url = {https://doi.org/10.1016/j.immuni.2017.08.008} } @article{ali2025-40665052, author = {Ali, Muhammad and Erabadda, Buddhiprabha and Chen, Yike and Xu, Ying and Gong, Katherine and Liu, Menghan and Binette, Alexa Pichet and Timsina, Jigyasha and others}, title = {{Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases}}, journal = {Nature Medicine}, year = {2025}, doi = {10.1038/s41591-025-03833-1}, pmid = {40665052}, url = {https://doi.org/10.1038/s41591-025-03833-1} } @article{barthelemy2020-32057125, author = {Barthélemy, N. R. and Liu, H. and Lu, W. and Kotzbauer, P. T. and Bateman, R. J. and Lucey, B. P.}, title = {{Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid}}, journal = {Annals of neurology}, year = {2020}, doi = {10.1002/ana.25702}, pmid = {32057125}, url = {https://doi.org/10.1002/ana.25702} } @article{wang2015-25728668, author = {Wang, Y. and Cella, M. and Mallinson, K. and Ulrich, J. D. and Young, K. L. and Robinette, M. L. and Gilfillan, S. and Krishnan, G. M. and others}, title = {{TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model}}, journal = {Cell}, year = {2015}, doi = {10.1016/j.cell.2015.01.049}, pmid = {25728668}, url = {https://doi.org/10.1016/j.cell.2015.01.049} } @article{kang2009-19779148, author = {Kang, Jae-Eun and Lim, Miranda M. and Bateman, Randall John and Lee, James J. and Smyth, Liam P. and Cirrito, John R. and Fujiki, Nobuhiro and Nishino, Seiji and Holtzman, David M.}, title = {{Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle}}, journal = {Science}, year = {2009}, doi = {10.1126/science.1180962}, pmid = {19779148}, url = {https://doi.org/10.1126/science.1180962} } @article{brier2016-27169802, author = {Brier, M. R. and Gordon, B. and Friedrichsen, K. and McCarthy, J. and Stern, A. and Christensen, J. and Owen, C. and Aldea, P. and others}, title = {{Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease}}, journal = {Science translational medicine}, year = {2016}, doi = {10.1126/scitranslmed.aaf2362}, pmid = {27169802}, url = {https://doi.org/10.1126/scitranslmed.aaf2362} } @article{vos2013-24012374, author = {Vos, S. J. and Xiong, C. and Visser, P. J. and Jasielec, M. S. and Hassenstab, J. and Grant, E. A. and Cairns, N. J. and Morris, J. C. and others}, title = {{Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study}}, journal = {The Lancet. Neurology}, year = {2013}, doi = {10.1016/s1474-4422(13)70194-7}, pmid = {24012374}, url = {https://doi.org/10.1016/s1474-4422(13)70194-7} } @article{bell2012-22622580, author = {Bell, R. D. and Winkler, E. A. and Singh, I. and Sagare, A. P. and Deane, R. and Wu, Z. and Holtzman, D. M. and Betsholtz, C. and others}, title = {{Apolipoprotein E controls cerebrovascular integrity via cyclophilin A}}, journal = {Nature}, year = {2012}, doi = {10.1038/nature11087}, pmid = {22622580}, url = {https://doi.org/10.1038/nature11087} } @article{tarawneh2016-27018940, author = {Tarawneh, R. and D'Angelo, G. and Crimmins, D. and Herries, E. and Griest, T. and Fagan, A. M. and Zipfel, G. J. and Ladenson, J. H. and others}, title = {{Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.0086}, pmid = {27018940}, url = {https://doi.org/10.1001/jamaneurol.2016.0086} } @article{damesquita2021-33911285, author = {Da Mesquita, S. and Papadopoulos, Z. and Dykstra, T. and Brase, L. and Farias, F. G. and Wall, M. and Jiang, H. and Kodira, C. D. and others}, title = {{Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy}}, journal = {Nature}, year = {2021}, doi = {10.1038/s41586-021-03489-0}, pmid = {33911285}, url = {https://doi.org/10.1038/s41586-021-03489-0} } @article{sanchezsanchez2022-34996522, author = {Sanchez-Sanchez, J. L. and Giudici, K. V. and Guyonnet, S. and Delrieu, J. and Li, Y. and Bateman, R. J. and Parini, A. and Vellas, B. and others}, title = {{Plasma MCP-1 and changes on cognitive function in community-dwelling older adults}}, journal = {Alzheimer's research \& therapy}, year = {2022}, doi = {10.1186/s13195-021-00940-2}, pmid = {34996522}, url = {https://doi.org/10.1186/s13195-021-00940-2} } @article{mawuenyega2010-21148344, author = {Mawuenyega, Kwasi G. and Sigurdson, Wendy C. and Ovod, Vitaliy and Munsell, Ling Y. and Kasten, Tom P. and Morris, John C. and Yarasheski, Kevin E. and Bateman, Randall John}, title = {{Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease}}, journal = {Science}, year = {2010}, doi = {10.1126/science.1197623}, pmid = {21148344}, url = {https://doi.org/10.1126/science.1197623} } @article{bradley2025-40556318, author = {Bradley, J. and Pottier, C. and da Fonseca, E. L. and Kurup, J. T. and Western, D. and Wang, C. and Neupane, A. and Ray, N. R. and Jean-Francois, M. and Ali, M. and Timsina, J. and Bergmann, K. and others}, title = {{Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70377}, pmid = {40556318}, url = {https://doi.org/10.1002/alz.70377} } @article{boerwinkle2023-36517172, author = {Boerwinkle, A. H. and Gordon, B. A. and Wisch, J. and Flores, S. and Henson, R. L. and Butt, O. H. and McKay, N. and Chen, C. D. and others}, title = {{Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2023}, doi = {10.1016/s1474-4422(22)00408-2}, pmid = {36517172}, url = {https://doi.org/10.1016/s1474-4422(22)00408-2} } @article{craigschapiro2010-21035623, author = {Craig-Schapiro, R. and Perrin, R. J. and Roe, C. M. and Xiong, C. and Carter, D. and Cairns, N. J. and Mintun, M. A. and Peskind, E. R. and others}, title = {{YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease}}, journal = {Biological psychiatry}, year = {2010}, doi = {10.1016/j.biopsych.2010.08.025}, pmid = {21035623}, url = {https://doi.org/10.1016/j.biopsych.2010.08.025} } @article{wang2016-27091843, author = {Wang, Y. and Ulland, T. K. and Ulrich, J. D. and Song, W. and Tzaferis, J. A. and Hole, J. T. and Yuan, P. and Mahan, T. E. and others}, title = {{TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques}}, journal = {The Journal of experimental medicine}, year = {2016}, doi = {10.1084/jem.20151948}, pmid = {27091843}, url = {https://doi.org/10.1084/jem.20151948} } @article{ewers2020-32790063, author = {Ewers, M. and Biechele, G. and Suárez-Calvet, M. and Sacher, C. and Blume, T. and Morenas-Rodriguez, E. and Deming, Y. and Piccio, L. and others}, title = {{Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation}}, journal = {EMBO molecular medicine}, year = {2020}, doi = {10.15252/emmm.202012308}, pmid = {32790063}, url = {https://doi.org/10.15252/emmm.202012308} } @article{gordon2019-30753379, author = {Gordon, B. A. and Blazey, T. M. and Christensen, J. and Dincer, A. and Flores, S. and Keefe, S. and Chen, C. and Su, Y. and others}, title = {{Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers}}, journal = {Brain : a journal of neurology}, year = {2019}, doi = {10.1093/brain/awz019}, pmid = {30753379}, url = {https://doi.org/10.1093/brain/awz019} } @article{brier2012-22745490, author = {Brier, M. R. and Thomas, J. B. and Snyder, A. Z. and Benzinger, T. L. and Zhang, D. and Raichle, M. E. and Holtzman, D. M. and Morris, J. C. and others}, title = {{Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2012}, doi = {10.1523/jneurosci.5698-11.2012}, pmid = {22745490}, url = {https://doi.org/10.1523/jneurosci.5698-11.2012} } @article{ulland2017-28802038, author = {Ulland, T. K. and Song, W. M. and Huang, S. C. and Ulrich, J. D. and Sergushichev, A. and Beatty, W. L. and Loboda, A. A. and Zhou, Y. and others}, title = {{TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease}}, journal = {Cell}, year = {2017}, doi = {10.1016/j.cell.2017.07.023}, pmid = {28802038}, url = {https://doi.org/10.1016/j.cell.2017.07.023} } @article{leyns2019-31235932, author = {Leyns, C. E. G. and Gratuze, M. and Narasimhan, S. and Jain, N. and Koscal, L. J. and Jiang, H. and Manis, M. and Colonna, M. and others}, title = {{TREM2 function impedes tau seeding in neuritic plaques}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-019-0433-0}, pmid = {31235932}, url = {https://doi.org/10.1038/s41593-019-0433-0} } @article{tarawneh2015-25867677, author = {Tarawneh, R. and Head, D. and Allison, S. and Buckles, V. and Fagan, A. M. and Ladenson, J. H. and Morris, J. C. and Holtzman, D. M.}, title = {{Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2015.0202}, pmid = {25867677}, url = {https://doi.org/10.1001/jamaneurol.2015.0202} } @article{long2019-31564456, author = {Long, Justin M. and Holtzman, David M.}, title = {{Alzheimer Disease: An Update on Pathobiology and Treatment Strategies}}, journal = {Cell}, year = {2019}, doi = {10.1016/j.cell.2019.09.001}, pmid = {31564456}, url = {https://doi.org/10.1016/j.cell.2019.09.001} } @article{dubois2016-27012484, author = {Dubois, Bruno and Hampel, Harald Juergen and Feldman, Howard and Scheltens, Philip and Aisen, Paul S. S. and Andrieu, Sandrine and Bakardjian, Hovagim and Benali, Habib and Bertram, Lars and Blennow, Kaj and Broich, Karl and Cavedo, Enrica and Crutch, Sebastian James and Dartigues, Jean‐François and Duyckaerts, Charles J. and Epelbaum, Stéphane and Frisoni, Giovanni Battista and Gauthier, Serge G. and Genthon, Rémy and Gouw, Alida A. and Habert, Marie‐Odile and Holtzman, David M. and Kivipelto, Miia and Lista, Simone and Molinuevo, José Luís and O’Bryant, Sid E. and Rabinovici, Gil D. and Rowe, Christopher Cleon and Salloway, Stephen and Schneider, Lon S. S. and Sperling, Reisa Anne and Teichmann, Marc and Carrillo, María C. and Cummings, Jeffrey L. and Jack, Clifford R.}, title = {{Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria}}, journal = {Alzheimer s \& Dementia}, year = {2016}, doi = {10.1016/j.jalz.2016.02.002}, pmid = {27012484}, url = {https://doi.org/10.1016/j.jalz.2016.02.002} } @article{fagan2006-16372280, author = {Fagan, A. M. and Mintun, M. A. and Mach, R. H. and Lee, S. Y. and Dence, C. S. and Shah, A. R. and LaRossa, G. N. and Spinner, M. L. and others}, title = {{Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans}}, journal = {Annals of neurology}, year = {2006}, doi = {10.1002/ana.20730}, pmid = {16372280}, url = {https://doi.org/10.1002/ana.20730} } @article{martens2022-35298921, author = {Martens, Y. A. and Zhao, N. and Liu, C. C. and Kanekiyo, T. and Yang, A. J. and Goate, A. M. and Holtzman, D. M. and Bu, G.}, title = {{ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias}}, journal = {Neuron}, year = {2022}, doi = {10.1016/j.neuron.2022.03.004}, pmid = {35298921}, url = {https://doi.org/10.1016/j.neuron.2022.03.004} } @article{bateman2006-16799555, author = {Bateman, R. J. and Munsell, L. Y. and Morris, J. C. and Swarm, R. and Yarasheski, K. E. and Holtzman, D. M.}, title = {{Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo}}, journal = {Nature medicine}, year = {2006}, doi = {10.1038/nm1438}, pmid = {16799555}, url = {https://doi.org/10.1038/nm1438} } @article{wang2022-36306735, author = {Wang, S. and Sudan, R. and Peng, V. and Zhou, Y. and Du, S. and Yuede, C. M. and Lei, T. and Hou, J. and others}, title = {{TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways}}, journal = {Cell}, year = {2022}, doi = {10.1016/j.cell.2022.09.033}, pmid = {36306735}, url = {https://doi.org/10.1016/j.cell.2022.09.033} } @article{cignarella2020-32772264, author = {Cignarella, F. and Filipello, F. and Bollman, B. and Cantoni, C. and Locca, A. and Mikesell, R. and Manis, M. and Ibrahim, A. and others}, title = {{TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis}}, journal = {Acta neuropathologica}, year = {2020}, doi = {10.1007/s00401-020-02193-z}, pmid = {32772264}, url = {https://doi.org/10.1007/s00401-020-02193-z} } @article{lu2025-39957622, author = {Lu, R. and Shah, K. and Toedebusch, C. D. and Hess, A. and Richardson, R. and Mignot, E. and Schindler, S. E. and Benzinger, T. L. S. and others}, title = {{Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance}}, journal = {Annals of clinical and translational neurology}, year = {2025}, doi = {10.1002/acn3.70009}, pmid = {39957622}, url = {https://doi.org/10.1002/acn3.70009} } @article{babulal2016-27426238, author = {Babulal, G. M. and Ghoshal, N. and Head, D. and Vernon, E. K. and Holtzman, D. M. and Benzinger, T. L. S. and Fagan, A. M. and Morris, J. C. and others}, title = {{Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2016}, doi = {10.1016/j.jagp.2016.04.004}, pmid = {27426238}, url = {https://doi.org/10.1016/j.jagp.2016.04.004} } @article{kim2009-19679070, author = {Kim, Jungsu and Basak, Jacob M. and Holtzman, David M.}, title = {{The Role of Apolipoprotein E in Alzheimer's Disease}}, journal = {Neuron}, year = {2009}, doi = {10.1016/j.neuron.2009.06.026}, pmid = {19679070}, url = {https://doi.org/10.1016/j.neuron.2009.06.026} } @article{castellano2011-21715678, author = {Castellano, Joseph M. and Kim, Jungsu and Stewart, Floy R. and Jiang, Hong and Demattos, Ronald Bradley and Patterson, Bruce W. and Fagan, Anne M. and Morris, John C. and Mawuenyega, Kwasi G. and Cruchaga, Carlos C and Goate, Alison and Bales, Kelly R. and Paul, Steven M. and Bateman, Randall John and Holtzman, David M.}, title = {{Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance}}, journal = {Science Translational Medicine}, year = {2011}, doi = {10.1126/scitranslmed.3002156}, pmid = {21715678}, url = {https://doi.org/10.1126/scitranslmed.3002156} } @article{jack2013-24360540, author = {Jack, Clifford R. and Holtzman, David M.}, title = {{Biomarker Modeling of Alzheimer’s Disease}}, journal = {Neuron}, year = {2013}, doi = {10.1016/j.neuron.2013.12.003}, pmid = {24360540}, url = {https://doi.org/10.1016/j.neuron.2013.12.003} } @article{perrin2009-19829371, author = {Perrin, R. J. and Fagan, A. M. and Holtzman, D. M.}, title = {{Multimodal techniques for diagnosis and prognosis of Alzheimer's disease}}, journal = {Nature}, year = {2009}, doi = {10.1038/nature08538}, pmid = {19829371}, url = {https://doi.org/10.1038/nature08538} } @article{tarawneh2011-21823155, author = {Tarawneh, R. and D'Angelo, G. and Macy, E. and Xiong, C. and Carter, D. and Cairns, N. J. and Fagan, A. M. and Head, D. and others}, title = {{Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22448}, pmid = {21823155}, url = {https://doi.org/10.1002/ana.22448} } @article{holtzman2011-21471435, author = {Holtzman, D. M. and Morris, J. C. and Goate, A. M.}, title = {{Alzheimer's disease: the challenge of the second century}}, journal = {Science translational medicine}, year = {2011}, doi = {10.1126/scitranslmed.3002369}, pmid = {21471435}, url = {https://doi.org/10.1126/scitranslmed.3002369} } @article{perrin2011-21264269, author = {Perrin, R. J. and Craig-Schapiro, R. and Malone, J. P. and Shah, A. R. and Gilmore, P. and Davis, A. E. and Roe, C. M. and Peskind, E. R. and others}, title = {{Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease}}, journal = {PloS one}, year = {2011}, doi = {10.1371/journal.pone.0016032}, pmid = {21264269}, url = {https://doi.org/10.1371/journal.pone.0016032} } @article{kester2015-26383836, author = {Kester, M. I. and Teunissen, C. E. and Sutphen, C. and Herries, E. M. and Ladenson, J. H. and Xiong, C. and Scheltens, P. and van der Flier, W. M. and others}, title = {{Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort}}, journal = {Alzheimer's research \& therapy}, year = {2015}, doi = {10.1186/s13195-015-0142-1}, pmid = {26383836}, url = {https://doi.org/10.1186/s13195-015-0142-1} } @article{karch2015-24951455, author = {Karch, C. M. and Goate, A. M.}, title = {{Alzheimer's disease risk genes and mechanisms of disease pathogenesis}}, journal = {Biological psychiatry}, year = {2015}, doi = {10.1016/j.biopsych.2014.05.006}, pmid = {24951455}, url = {https://doi.org/10.1016/j.biopsych.2014.05.006} } @article{cruchaga2013-23562540, author = {Cruchaga, Carlos C and Kauwe, John S. K. and Harari, Oscar and Jin, Sheng Chih and Cai, Yefei and Karch, Celeste M M. and Benítez, Bruno A. and Jeng, Amanda T. and Skorupa, Tara and Carrell, David and Bertelsen, Sarah E. and Bailey, Matthew H. and McKean, David M. and Shulman, Joshua M and De Jager, Philip L. and Chibnik, Lori Beth and Bennett, David and Arnold, S. E. and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Williams, Julie H. and Van Deerlin, Vivianna M. and Lee, Virginia M.‐Y. and Shaw, Leslie M. and Trojanowski, John Q. and Haines, Jonathan L. and Mayeux, Richard P and Pericak‐Vance, Margaret A. and Farrer, Lindsay A. and Schellenberg, Gerard D. and Peskind, Elaine R. and Galasko, Douglas R and Fagan, Anne M. and Holtzman, David M. and Morris, John C. and Goate, Alison}, title = {{GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease}}, journal = {Neuron}, year = {2013}, doi = {10.1016/j.neuron.2013.02.026}, pmid = {23562540}, url = {https://doi.org/10.1016/j.neuron.2013.02.026} } @article{verghese2011-21349439, author = {Verghese, Philip B. and Castellano, Joseph M. and Holtzman, David M.}, title = {{Apolipoprotein E in Alzheimer's disease and other neurological disorders}}, journal = {The Lancet Neurology}, year = {2011}, doi = {10.1016/s1474-4422(10)70325-2}, pmid = {21349439}, url = {https://doi.org/10.1016/s1474-4422(10)70325-2} } @article{brase2023-37085492, author = {Brase, L. and You, S. F. and D'Oliveira Albanus, R. and Del-Aguila, J. L. and Dai, Y. and Novotny, B. C. and Soriano-Tarraga, C. and Dykstra, T. and others}, title = {{Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers}}, journal = {Nature communications}, year = {2023}, doi = {10.1038/s41467-023-37437-5}, pmid = {37085492}, url = {https://doi.org/10.1038/s41467-023-37437-5} } @article{fagan2011-21555603, author = {Fagan, A. M. and Shaw, L. M. and Xiong, C. and Vanderstichele, H. and Mintun, M. A. and Trojanowski, J. Q. and Coart, E. and Morris, J. C. and others}, title = {{Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2011.105}, pmid = {21555603}, url = {https://doi.org/10.1001/archneurol.2011.105} } @article{cady2014-24535663, author = {Cady, J. and Koval, E. D. and Benitez, B. A. and Zaidman, C. and Jockel-Balsarotti, J. and Allred, P. and Baloh, R. H. and Ravits, J. and others}, title = {{TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2013.6237}, pmid = {24535663}, url = {https://doi.org/10.1001/jamaneurol.2013.6237} } @article{leyns2017-29073081, author = {Leyns, C. E. G. and Ulrich, J. D. and Finn, M. B. and Stewart, F. R. and Koscal, L. J. and Remolina Serrano, J. and Robinson, G. O. and Anderson, E. and others}, title = {{TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2017}, doi = {10.1073/pnas.1710311114}, pmid = {29073081}, url = {https://doi.org/10.1073/pnas.1710311114} } @article{schindler2019-30846386, author = {Schindler, S. E. and Li, Y. and Todd, K. W. and Herries, E. M. and Henson, R. L. and Gray, J. D. and Wang, G. and Graham, D. L. and others}, title = {{Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2018.12.019}, pmid = {30846386}, url = {https://doi.org/10.1016/j.jalz.2018.12.019} } @article{ali2022-35617280, author = {Ali, M. and Sung, Y. J. and Wang, F. and Fernández, M. V. and Morris, J. C. and Fagan, A. M. and Blennow, K. and Zetterberg, H. and others}, title = {{Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk}}, journal = {PloS one}, year = {2022}, doi = {10.1371/journal.pone.0267298}, pmid = {35617280}, url = {https://doi.org/10.1371/journal.pone.0267298} } @article{cirrito2005-16364896, author = {Cirrito, John R. and Yamada, Kelvin A. and Finn, Mary Beth and Sloviter, Robert S. and Bales, Kelly R. and May, Patrick C. and Schoepp, Darryle D. and Paul, Steven M. and Mennerick, Steven J. and Holtzman, David M.}, title = {{Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo}}, journal = {Neuron}, year = {2005}, doi = {10.1016/j.neuron.2005.10.028}, pmid = {16364896}, url = {https://doi.org/10.1016/j.neuron.2005.10.028} } @article{deane2008-19033669, author = {Deane, R. and Sagare, A. and Hamm, K. and Parisi, M. and Lane, S. and Finn, M. B. and Holtzman, D. M. and Zlokovic, B. V.}, title = {{apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain}}, journal = {The Journal of clinical investigation}, year = {2008}, doi = {10.1172/jci36663}, pmid = {19033669}, url = {https://doi.org/10.1172/jci36663} } @article{bayat2021-34127064, author = {Bayat, S. and Babulal, G. M. and Schindler, S. E. and Fagan, A. M. and Morris, J. C. and Mihailidis, A. and Roe, C. M.}, title = {{GPS driving: a digital biomarker for preclinical Alzheimer disease}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00852-1}, pmid = {34127064}, url = {https://doi.org/10.1186/s13195-021-00852-1} } @article{suarezcalvet2016-27974666, author = {Suárez-Calvet, M. and MÁ, Araque Caballero and Kleinberger, G. and Bateman, R. J. and Fagan, A. M. and Morris, J. C. and Levin, J. and Danek, A. and others}, title = {{Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury}}, journal = {Science translational medicine}, year = {2016}, doi = {10.1126/scitranslmed.aag1767}, pmid = {27974666}, url = {https://doi.org/10.1126/scitranslmed.aag1767} } @article{gratuze2020-32544086, author = {Gratuze, M. and Leyns, C. E. and Sauerbeck, A. D. and St-Pierre, M. K. and Xiong, M. and Kim, N. and Serrano, JR. and MÈ, Tremblay and others}, title = {{Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration}}, journal = {The Journal of clinical investigation}, year = {2020}, doi = {10.1172/jci138179}, pmid = {32544086}, url = {https://doi.org/10.1172/jci138179} } @article{gratuze2021-34100905, author = {Gratuze, M. and Chen, Y. and Parhizkar, S. and Jain, N. and Strickland, M. R. and Serrano, JR. and Colonna, M. and Ulrich, J. D. and others}, title = {{Activated microglia mitigate Aβ-associated tau seeding and spreading}}, journal = {The Journal of experimental medicine}, year = {2021}, doi = {10.1084/jem.20210542}, pmid = {34100905}, url = {https://doi.org/10.1084/jem.20210542} } @article{ma2018-30239611, author = {MÁ, Araque Caballero and Suárez-Calvet, M. and Duering, M. and Franzmeier, N. and Benzinger, T. and Fagan, A. M. and Bateman, R. J. and Jack, C. R. and others}, title = {{White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2018}, doi = {10.1093/brain/awy229}, pmid = {30239611}, url = {https://doi.org/10.1093/brain/awy229} } @article{jain2023-36219197, author = {Jain, N. and Lewis, C. A. and Ulrich, J. D. and Holtzman, D. M.}, title = {{Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading}}, journal = {The Journal of experimental medicine}, year = {2023}, doi = {10.1084/jem.20220654}, pmid = {36219197}, url = {https://doi.org/10.1084/jem.20220654} } @article{tarawneh2026-42098850, author = {Tarawneh, Rawan M. and Moulder, Krista L. and Topouza, Danai Georgia and Kar, Amrita Ghosh and Qian, Heng and Pankratz, V. Shane and Timsina, Jigyasha and Franklin, Erin E. and others}, title = {{Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease}}, journal = {Alzheimer s Research \& Therapy}, year = {2026}, doi = {10.1186/s13195-026-02043-2}, pmid = {42098850}, url = {https://doi.org/10.1186/s13195-026-02043-2} } @article{chen2026-41785364, author = {Chen, Yun and Liu, Yizhou A. and Nguyen, Khai M. and Wu, Junjie and Song, Sihui and Lin, Kent and Rodrigues, Patrick Fernandes and Du, Siling and others}, title = {{Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy}}, journal = {Science}, year = {2026}, doi = {10.1126/science.ads3972}, pmid = {41785364}, url = {https://doi.org/10.1126/science.ads3972} } @article{shi2018-30140051, author = {Shi, Y. and Holtzman, D. M.}, title = {{Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight}}, journal = {Nature reviews. Immunology}, year = {2018}, doi = {10.1038/s41577-018-0051-1}, pmid = {30140051}, url = {https://doi.org/10.1038/s41577-018-0051-1} } @article{deming2019-31413141, author = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others}, title = {{The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk}}, journal = {Science translational medicine}, year = {2019}, doi = {10.1126/scitranslmed.aau2291}, pmid = {31413141}, url = {https://doi.org/10.1126/scitranslmed.aau2291} } @article{margeta2022-35977543, author = {Margeta, M. A. and Yin, Z. and Madore, C. and Pitts, K. M. and Letcher, S. M. and Tang, J. and Jiang, S. and Gauthier, C. D. and others}, title = {{Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma}}, journal = {Immunity}, year = {2022}, doi = {10.1016/j.immuni.2022.07.014}, pmid = {35977543}, url = {https://doi.org/10.1016/j.immuni.2022.07.014} } @article{faraco2019-31645758, author = {Faraco, G. and Hochrainer, K. and Segarra, S. G. and Schaeffer, S. and Santisteban, M. M. and Menon, A. and Jiang, H. and Holtzman, D. M. and others}, title = {{Dietary salt promotes cognitive impairment through tau phosphorylation}}, journal = {Nature}, year = {2019}, doi = {10.1038/s41586-019-1688-z}, pmid = {31645758}, url = {https://doi.org/10.1038/s41586-019-1688-z} } @article{wang2016-27454922, author = {Wang, L. and Benzinger, T. L. and Su, Y. and Christensen, J. and Friedrichsen, K. and Aldea, P. and McConathy, J. and Cairns, N. J. and others}, title = {{Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.2078}, pmid = {27454922}, url = {https://doi.org/10.1001/jamaneurol.2016.2078} } @article{dhavale2024-38553463, author = {Dhavale, D. D. and Barclay, A. M. and Borcik, C. G. and Basore, K. and Berthold, D. A. and Gordon, I. R. and Liu, J. and Milchberg, M. H. and others}, title = {{Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue}}, journal = {Nature communications}, year = {2024}, doi = {10.1038/s41467-024-46832-5}, pmid = {38553463}, url = {https://doi.org/10.1038/s41467-024-46832-5} } @article{lanctot2017-29067350, author = {Lanctôt, K. L. and Amatniek, J. and Ancoli-Israel, S. and Arnold, S. E. and Ballard, C. and Cohen-Mansfield, J. and Ismail, Z. and Lyketsos, C. and others}, title = {{Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2017}, doi = {10.1016/j.trci.2017.07.001}, pmid = {29067350}, url = {https://doi.org/10.1016/j.trci.2017.07.001} } @article{gratuze2018-30572908, author = {Gratuze, M. and Leyns, C. E. G. and Holtzman, D. M.}, title = {{New insights into the role of TREM2 in Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2018}, doi = {10.1186/s13024-018-0298-9}, pmid = {30572908}, url = {https://doi.org/10.1186/s13024-018-0298-9} } @article{ulrich2017-28426958, author = {Ulrich, J. D. and Ulland, T. K. and Colonna, M. and Holtzman, D. M.}, title = {{Elucidating the Role of TREM2 in Alzheimer's Disease}}, journal = {Neuron}, year = {2017}, doi = {10.1016/j.neuron.2017.02.042}, pmid = {28426958}, url = {https://doi.org/10.1016/j.neuron.2017.02.042} } @article{delaguila2018-29480181, author = {Del-Aguila, J. L. and Fernández, M. V. and Schindler, S. and Ibanez, L. and Deming, Y. and Ma, S. and Saef, B. and Black, K. and others}, title = {{Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2018}, doi = {10.3233/jad-170834}, pmid = {29480181}, url = {https://doi.org/10.3233/jad-170834} } @article{leyns2017-28662669, author = {Leyns, C. E. G. and Holtzman, D. M.}, title = {{Glial contributions to neurodegeneration in tauopathies}}, journal = {Molecular neurodegeneration}, year = {2017}, doi = {10.1186/s13024-017-0192-x}, pmid = {28662669}, url = {https://doi.org/10.1186/s13024-017-0192-x} } @article{bu2009-19339974, author = {Bu, Guojun}, title = {{Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy}}, journal = {Nature reviews. Neuroscience}, year = {2009}, doi = {10.1038/nrn2620}, pmid = {19339974}, url = {https://doi.org/10.1038/nrn2620} } @article{chen2021-33176118, author = {Chen, Y. and Strickland, M. R. and Soranno, A. and Holtzman, D. M.}, title = {{Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis}}, journal = {Neuron}, year = {2021}, doi = {10.1016/j.neuron.2020.10.008}, pmid = {33176118}, url = {https://doi.org/10.1016/j.neuron.2020.10.008} } @article{jun2017-28183528, author = {Jun, G. R. and Chung, J. and Mez, J. and Barber, R. and Beecham, G. W. and Bennett, D. A. and Buxbaum, J. D. and Byrd, G. S. and others}, title = {{Transethnic genome-wide scan identifies novel Alzheimer's disease loci}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.12.012}, pmid = {28183528}, url = {https://doi.org/10.1016/j.jalz.2016.12.012} } @article{liao2018-29600961, author = {Liao, F. and Li, A. and Xiong, M. and Bien-Ly, N. and Jiang, H. and Zhang, Y. and Finn, M. B. and Hoyle, R. and others}, title = {{Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation}}, journal = {The Journal of clinical investigation}, year = {2018}, doi = {10.1172/jci96429}, pmid = {29600961}, url = {https://doi.org/10.1172/jci96429} } @article{benitez2013-23391427, author = {Benitez, B. A. and Cooper, B. and Pastor, P. and Jin, S. C. and Lorenzo, E. and Cervantes, S. and Cruchaga, C.}, title = {{TREM2 is associated with the risk of Alzheimer's disease in Spanish population}}, journal = {Neurobiology of aging}, year = {2013}, doi = {10.1016/j.neurobiolaging.2012.12.018}, pmid = {23391427}, url = {https://doi.org/10.1016/j.neurobiolaging.2012.12.018} } @article{lajoie2018-29282337, author = {La Joie, R. and Bejanin, A. and Fagan, A. M. and Ayakta, N. and Baker, S. L. and Bourakova, V. and Boxer, A. L. and Cha, J. and others}, title = {{Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000004860}, pmid = {29282337}, url = {https://doi.org/10.1212/wnl.0000000000004860} } @article{ewers2019-31462511, author = {Ewers, M. and Franzmeier, N. and Suárez-Calvet, M. and Morenas-Rodriguez, E. and Caballero, M. A. A. and Kleinberger, G. and Piccio, L. and Cruchaga, C. and others}, title = {{Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease}}, journal = {Science translational medicine}, year = {2019}, doi = {10.1126/scitranslmed.aav6221}, pmid = {31462511}, url = {https://doi.org/10.1126/scitranslmed.aav6221} } @article{delaguila2019-31068200, author = {Del-Aguila, J. L. and Benitez, B. A. and Li, Z. and Dube, U. and Mihindukulasuriya, K. A. and Budde, J. P. and Farias, F. H. G. and Fernández, M. V. and others}, title = {{TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-019-0319-3}, pmid = {31068200}, url = {https://doi.org/10.1186/s13024-019-0319-3} } @article{gratuze2023-36368315, author = {Gratuze, M. and Schlachetzki, J. C. M. and D'Oliveira Albanus, R. and Jain, N. and Novotny, B. and Brase, L. and Rodriguez, L. and Mansel, C. and others}, title = {{TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4}}, journal = {Neuron}, year = {2023}, doi = {10.1016/j.neuron.2022.10.022}, pmid = {36368315}, url = {https://doi.org/10.1016/j.neuron.2022.10.022} } @article{gordon2016-27286736, author = {Gordon, B. A. and Friedrichsen, K. and Brier, M. and Blazey, T. and Su, Y. and Christensen, J. and Aldea, P. and McConathy, J. and others}, title = {{The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging}}, journal = {Brain : a journal of neurology}, year = {2016}, doi = {10.1093/brain/aww139}, pmid = {27286736}, url = {https://doi.org/10.1093/brain/aww139} } @article{tarawneh2012-22357717, author = {Tarawneh, R. and Lee, J. M. and Ladenson, J. H. and Morris, J. C. and Holtzman, D. M.}, title = {{CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e318248e568}, pmid = {22357717}, url = {https://doi.org/10.1212/wnl.0b013e318248e568} } @article{karch2012-23226438, author = {Karch, C. M. and Jeng, A. T. and Nowotny, P. and Cady, J. and Cruchaga, C. and Goate, A. M.}, title = {{Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains}}, journal = {PloS one}, year = {2012}, doi = {10.1371/journal.pone.0050976}, pmid = {23226438}, url = {https://doi.org/10.1371/journal.pone.0050976} } @article{piccio2008-18790823, author = {Piccio, Laura M. and Buonsanti, Cecilia and Cella, Marina and Tassi, Ilaria and Schmidt, Robert E. and Fenoglio, Chiara and Rinker, John Robert and Naismith, Robert T. and Panina‐Bordignon, Paola and Passini, Nadia and Galimberti, Daniela and Scarpini, Elio Angelo and Colonna, Marco and Cross, Anne Haney}, title = {{Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation}}, journal = {Brain}, year = {2008}, doi = {10.1093/brain/awn217}, pmid = {18790823}, url = {https://doi.org/10.1093/brain/awn217} } @article{mahan2022-35109920, author = {Mahan, T. E. and Wang, C. and Bao, X. and Choudhury, A. and Ulrich, J. D. and Holtzman, D. M.}, title = {{Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis}}, journal = {Molecular neurodegeneration}, year = {2022}, doi = {10.1186/s13024-022-00516-0}, pmid = {35109920}, url = {https://doi.org/10.1186/s13024-022-00516-0} } @article{huynh2017-29216448, author = {Huynh, T. V. and Liao, F. and Francis, C. M. and Robinson, G. O. and Serrano, JR. and Jiang, H. and Roh, J. and Finn, M. B. and others}, title = {{Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis}}, journal = {Neuron}, year = {2017}, doi = {10.1016/j.neuron.2017.11.014}, pmid = {29216448}, url = {https://doi.org/10.1016/j.neuron.2017.11.014} } @article{wegorzewska2009-19833869, author = {Wegorzewska, I. and Bell, S. and Cairns, N. J. and Miller, T. M. and Baloh, R. H.}, title = {{TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2009}, doi = {10.1073/pnas.0908767106}, pmid = {19833869}, url = {https://doi.org/10.1073/pnas.0908767106} } @article{esparza2013-23225543, author = {Esparza, T. J. and Zhao, H. and Cirrito, JR. and Cairns, N. J. and Bateman, R. J. and Holtzman, D. M. and Brody, D. L.}, title = {{Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls}}, journal = {Annals of neurology}, year = {2013}, doi = {10.1002/ana.23748}, pmid = {23225543}, url = {https://doi.org/10.1002/ana.23748} } @article{musiek2015-25766617, author = {Musiek, E. S. and Xiong, D. D. and Holtzman, D. M.}, title = {{Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease}}, journal = {Experimental \& molecular medicine}, year = {2015}, doi = {10.1038/emm.2014.121}, pmid = {25766617}, url = {https://doi.org/10.1038/emm.2014.121} } @article{petersen2025-41442191, author = {Petersen, Kellen K. and Milà‐Alomà, Marta and Tosun, Duygu and Li, Yan and Saef, Benjamin A. and Shaw, Leslie M. and Dage, Jeffrey L. and Zetterberg, Henrik and others}, title = {{Predicting onset of Alzheimer disease symptoms with a plasma \%p‐tau217 clock}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70856_099674}, pmid = {41442191}, url = {https://doi.org/10.1002/alz70856_099674} } @article{holtzman2012-22393530, author = {Holtzman, D. M. and Herz, J. and Bu, G.}, title = {{Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease}}, journal = {Cold Spring Harbor perspectives in medicine}, year = {2012}, doi = {10.1101/cshperspect.a006312}, pmid = {22393530}, url = {https://doi.org/10.1101/cshperspect.a006312} } @article{wahrle2008-18202749, author = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Kim, J. and Li, A. and Knoten, A. and Jain, S. and Hirsch-Reinshagen, V. and others}, title = {{Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease}}, journal = {The Journal of clinical investigation}, year = {2008}, doi = {10.1172/jci33622}, pmid = {18202749}, url = {https://doi.org/10.1172/jci33622} } @article{huynh2019-31623648, author = {Huynh, T. V. and Wang, C. and Tran, A. C. and Tabor, G. T. and Mahan, T. E. and Francis, C. M. and Finn, M. B. and Spellman, R. and others}, title = {{Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-019-0337-1}, pmid = {31623648}, url = {https://doi.org/10.1186/s13024-019-0337-1} } @article{wang2013-23959173, author = {Wang, L. and Brier, M. R. and Snyder, A. Z. and Thomas, J. B. and Fagan, A. M. and Xiong, C. and Benzinger, T. L. and Holtzman, D. M. and others}, title = {{Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.3253}, pmid = {23959173}, url = {https://doi.org/10.1001/jamaneurol.2013.3253} } @article{craigschapiro2011-21526197, author = {Craig-Schapiro, R. and Kuhn, M. and Xiong, C. and Pickering, E. H. and Liu, J. and Misko, T. P. and Perrin, R. J. and Bales, K. R. and others}, title = {{Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis}}, journal = {PloS one}, year = {2011}, doi = {10.1371/journal.pone.0018850}, pmid = {21526197}, url = {https://doi.org/10.1371/journal.pone.0018850} } @article{ju2009-20008565, author = {Ju, J. S. and Fuentealba, R. A. and Miller, S. E. and Jackson, E. and Piwnica-Worms, D. and Baloh, R. H. and Weihl, C. C.}, title = {{Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease}}, journal = {The Journal of cell biology}, year = {2009}, doi = {10.1083/jcb.200908115}, pmid = {20008565}, url = {https://doi.org/10.1083/jcb.200908115} } @article{filipello2022-35041990, author = {Filipello, F. and Goldsbury, C. and You, S. F. and Locca, A. and Karch, C. M. and Piccio, L.}, title = {{Soluble TREM2: Innocent bystander or active player in neurological diseases?}}, journal = {Neurobiology of disease}, year = {2022}, doi = {10.1016/j.nbd.2022.105630}, pmid = {35041990}, url = {https://doi.org/10.1016/j.nbd.2022.105630} } @article{sun2023-37172094, author = {Sun, R. and Han, R. and McCornack, C. and Khan, S. and Tabor, G. T. and Chen, Y. and Hou, J. and Jiang, H. and others}, title = {{TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma}}, journal = {Science advances}, year = {2023}, doi = {10.1126/sciadv.ade3559}, pmid = {37172094}, url = {https://doi.org/10.1126/sciadv.ade3559} } @article{parhizkar2023-37099634, author = {Parhizkar, S. and Gent, G. and Chen, Y. and Rensing, N. and Gratuze, M. and Strout, G. and Sviben, S. and Tycksen, E. and others}, title = {{Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice}}, journal = {Science translational medicine}, year = {2023}, doi = {10.1126/scitranslmed.ade6285}, pmid = {37099634}, url = {https://doi.org/10.1126/scitranslmed.ade6285} } @article{carling2024-39353433, author = {Carling, G. K. and Fan, L. and Foxe, N. R. and Norman, K. and Wong, M. Y. and Zhu, D. and Corona, C. and Razzoli, A. and others}, title = {{Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model}}, journal = {Neuron}, year = {2024}, doi = {10.1016/j.neuron.2024.09.006}, pmid = {39353433}, url = {https://doi.org/10.1016/j.neuron.2024.09.006} } @article{kanekiyo2013-24305823, author = {Kanekiyo, T. and Cirrito, JR. and Liu, C. C. and Shinohara, M. and Li, J. and Schuler, D. R. and Holtzman, D. M. and others}, title = {{Neuronal clearance of amyloid-β by endocytic receptor LRP1}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2013}, doi = {10.1523/jneurosci.3487-13.2013}, pmid = {24305823}, url = {https://doi.org/10.1523/jneurosci.3487-13.2013} } @article{wang2015-25716355, author = {Wang, L. and Benzinger, T. L. and Hassenstab, J. and Blazey, T. and Owen, C. and Liu, J. and Fagan, A. M. and Morris, J. C. and others}, title = {{Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001401}, pmid = {25716355}, url = {https://doi.org/10.1212/wnl.0000000000001401} } @article{hashimoto2012-23100439, author = {Hashimoto, T. and Serrano-Pozo, A. and Hori, Y. and Adams, K. W. and Takeda, S. and Banerji, A. O. and Mitani, A. and Joyner, D. and others}, title = {{Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2012}, doi = {10.1523/jneurosci.1542-12.2012}, pmid = {23100439}, url = {https://doi.org/10.1523/jneurosci.1542-12.2012} } @article{wildburger2017-28842697, author = {Wildburger, N. C. and Esparza, T. J. and LeDuc, R. D. and Fellers, R. T. and Thomas, P. M. and Cairns, N. J. and Kelleher, N. L. and Bateman, R. J. and others}, title = {{Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain}}, journal = {Scientific reports}, year = {2017}, doi = {10.1038/s41598-017-10422-x}, pmid = {28842697}, url = {https://doi.org/10.1038/s41598-017-10422-x} } @article{lessard2018-30341064, author = {Lessard, C. B. and Malnik, S. L. and Zhou, Y. and Ladd, T. B. and Cruz, P. E. and Ran, Y. and Mahan, T. E. and Chakrabaty, P. and others}, title = {{High-affinity interactions and signal transduction between Aβ oligomers and TREM2}}, journal = {EMBO molecular medicine}, year = {2018}, doi = {10.15252/emmm.201809027}, pmid = {30341064}, url = {https://doi.org/10.15252/emmm.201809027} } @article{lananna2020-33328329, author = {Lananna, B. V. and McKee, C. A. and King, M. W. and Del-Aguila, J. L. and Dimitry, J. M. and Farias, F. H. G. and Nadarajah, C. J. and Xiong, D. D. and others}, title = {{Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis}}, journal = {Science translational medicine}, year = {2020}, doi = {10.1126/scitranslmed.aax3519}, pmid = {33328329}, url = {https://doi.org/10.1126/scitranslmed.aax3519} } @article{stojanovic2020-32520736, author = {Stojanovic, M. and Jin, Y. and Fagan, A. M. and Benzinger, T. L. and Hassenstab, J. and Cruchaga, C. and Morris, J. C. and Head, D.}, title = {{Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning}}, journal = {Alzheimer disease and associated disorders}, year = {2020}, doi = {10.1097/wad.0000000000000385}, pmid = {32520736}, url = {https://doi.org/10.1097/wad.0000000000000385} } @article{smith2021-33430685, author = {Smith, R. X. and Strain, J. F. and Tanenbaum, A. and Fagan, A. M. and Hassenstab, J. and McDade, E. and Schindler, S. E. and Gordon, B. A. and others}, title = {{Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease}}, journal = {Brain connectivity}, year = {2021}, doi = {10.1089/brain.2020.0808}, pmid = {33430685}, url = {https://doi.org/10.1089/brain.2020.0808} } @article{wahrle2005-16207708, author = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Hartman, R. E. and Bales, K. R. and Paul, S. M. and Holtzman, D. M.}, title = {{Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m508780200}, pmid = {16207708}, url = {https://doi.org/10.1074/jbc.m508780200} } @article{basak2012-22383525, author = {Basak, J. M. and Verghese, P. B. and Yoon, H. and Kim, J. and Holtzman, D. M.}, title = {{Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes}}, journal = {The Journal of biological chemistry}, year = {2012}, doi = {10.1074/jbc.m111.288746}, pmid = {22383525}, url = {https://doi.org/10.1074/jbc.m111.288746} } @article{brendza2005-15668737, author = {Brendza, R. P. and Bacskai, B. J. and Cirrito, JR. and Simmons, K. A. and Skoch, J. M. and Klunk, W. E. and Mathis, C. A. and Bales, K. R. and others}, title = {{Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice}}, journal = {The Journal of clinical investigation}, year = {2005}, doi = {10.1172/jci23269}, pmid = {15668737}, url = {https://doi.org/10.1172/jci23269} } @article{wang2019-30901713, author = {Wang, Q. and Wang, Y. and Liu, J. and Sutphen, C. L. and Cruchaga, C. and Blazey, T. and Gordon, B. A. and Su, Y. and others}, title = {{Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease}}, journal = {NeuroImage. Clinical}, year = {2019}, doi = {10.1016/j.nicl.2019.101767}, pmid = {30901713}, url = {https://doi.org/10.1016/j.nicl.2019.101767} } @article{franzmeier2021-30899092, author = {Franzmeier, N. and Ren, J. and Damm, A. and Monté-Rubio, G. and Boada, M. and Ruiz, A. and Ramirez, A. and Jessen, F. and others}, title = {{The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2021}, doi = {10.1038/s41380-019-0404-6}, pmid = {30899092}, url = {https://doi.org/10.1038/s41380-019-0404-6} } @article{koenig2022-34655980, author = {Koenig, L. N. and LaMontagne, P. and Glasser, M. F. and Bateman, R. and Holtzman, D. and Yakushev, I. and Chhatwal, J. and Day, G. S. and others}, title = {{Regional age-related atrophy after screening for preclinical alzheimer disease}}, journal = {Neurobiology of aging}, year = {2022}, doi = {10.1016/j.neurobiolaging.2021.09.010}, pmid = {34655980}, url = {https://doi.org/10.1016/j.neurobiolaging.2021.09.010} } @article{xiao2012-22539346, author = {Xiao, Q. and Gil, S. C. and Yan, P. and Wang, Y. and Han, S. and Gonzales, E. and Perez, R. and Cirrito, JR. and others}, title = {{Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis}}, journal = {The Journal of biological chemistry}, year = {2012}, doi = {10.1074/jbc.m111.338376}, pmid = {22539346}, url = {https://doi.org/10.1074/jbc.m111.338376} } @article{suarezcalvet2018-30482868, author = {Suárez-Calvet, M. and Capell, A. and MÁ, Araque Caballero and Morenas-Rodríguez, E. and Fellerer, K. and Franzmeier, N. and Kleinberger, G. and Eren, E. and others}, title = {{CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline}}, journal = {EMBO molecular medicine}, year = {2018}, doi = {10.15252/emmm.201809712}, pmid = {30482868}, url = {https://doi.org/10.15252/emmm.201809712} } @article{patel2026-42127933, author = {Patel, M. and Feng, W. and Mckay, N. S. and Millar, P. R. and Liu, M. and Yang, C. and Cetin, A. and Johnson, M. and others}, title = {{Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study}}, journal = {The Lancet. Neurology}, year = {2026}, doi = {10.1016/s1474-4422(26)00123-7}, pmid = {42127933}, url = {https://doi.org/10.1016/s1474-4422(26)00123-7} } @article{fryer2005-15888448, author = {Fryer, J. D. and Demattos, R. B. and McCormick, L. M. and O'Dell, M. A. and Spinner, M. L. and Bales, K. R. and Paul, S. M. and Sullivan, P. M. and others}, title = {{The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m502143200}, pmid = {15888448}, url = {https://doi.org/10.1074/jbc.m502143200} } @article{lee2020-31800167, author = {Lee, J. and Kim, D. E. and Griffin, P. and Sheehan, P. W. and Kim, D. H. and Musiek, E. S. and Yoon, S. Y.}, title = {{Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease}}, journal = {Aging cell}, year = {2020}, doi = {10.1111/acel.13078}, pmid = {31800167}, url = {https://doi.org/10.1111/acel.13078} } @article{schoch2021-34187891, author = {Schoch, K. M. and Ezerskiy, L. A. and Morhaus, M. M. and Bannon, R. N. and Sauerbeck, A. D. and Shabsovich, M. and Jafar-Nejad, P. and Rigo, F. and others}, title = {{Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2021}, doi = {10.1073/pnas.2100356118}, pmid = {34187891}, url = {https://doi.org/10.1073/pnas.2100356118} } @article{karch2012-23105105, author = {Karch, C. M. and Jeng, A. T. and Goate, A. M.}, title = {{Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies}}, journal = {The Journal of biological chemistry}, year = {2012}, doi = {10.1074/jbc.m112.380642}, pmid = {23105105}, url = {https://doi.org/10.1074/jbc.m112.380642} } @article{blennow2012-22951438, author = {Blennow, K. and Zetterberg, H. and Fagan, A. M.}, title = {{Fluid biomarkers in Alzheimer disease}}, journal = {Cold Spring Harbor perspectives in medicine}, year = {2012}, doi = {10.1101/cshperspect.a006221}, pmid = {22951438}, url = {https://doi.org/10.1101/cshperspect.a006221} } @article{delaguila2019-31399126, author = {Del-Aguila, J. L. and Li, Z. and Dube, U. and Mihindukulasuriya, K. A. and Budde, J. P. and Fernandez, M. V. and Ibanez, L. and Bradley, J. and others}, title = {{A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain}}, journal = {Alzheimer's research \& therapy}, year = {2019}, doi = {10.1186/s13195-019-0524-x}, pmid = {31399126}, url = {https://doi.org/10.1186/s13195-019-0524-x} } @article{butt2021-33765432, author = {Butt, O. H. and Long, J. M. and Henson, R. L. and Herries, E. and Sutphen, C. L. and Fagan, A. M. and Cruchaga, C. and Ladenson, J. H. and others}, title = {{Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25}}, journal = {Neurobiology of aging}, year = {2021}, doi = {10.1016/j.neurobiolaging.2021.02.008}, pmid = {33765432}, url = {https://doi.org/10.1016/j.neurobiolaging.2021.02.008} } @article{lee2008-18703769, author = {Lee, J. M. and Blennow, K. and Andreasen, N. and Laterza, O. and Modur, V. and Olander, J. and Gao, F. and Ohlendorf, M. and others}, title = {{The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients}}, journal = {Clinical chemistry}, year = {2008}, doi = {10.1373/clinchem.2008.104497}, pmid = {18703769}, url = {https://doi.org/10.1373/clinchem.2008.104497} } @article{abdelmoity2025-40977577, author = {Abdelmoity, O. and Wisch, J. K. and Kennedy, J. T. and Goyal, M. and Vlassenko, A. and Flores, S. and Handen, B. L. and Head, E. and others}, title = {{Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease}}, journal = {Annals of neurology}, year = {2025}, doi = {10.1002/ana.78002}, pmid = {40977577}, url = {https://doi.org/10.1002/ana.78002} } @article{noh2026-42676462, author = {Noh, M. Y. and Sung, W. and Kim, H. and Son, B. and Kim, Y. E. and Choi, Y. Y. and Holtzman, D. M. and Kim, S. H.}, title = {{Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2026}, doi = {10.1002/dad2.70468}, pmid = {42676462}, url = {https://doi.org/10.1002/dad2.70468} } @article{brandao2025-39813317, author = {Brandão, Wesley Nogueira and Jain, Nimansha and Yin, Zhuoran and Kleemann, Kilian L. and Carpenter, Madison and Bao, Xin and Serrano, Javier Remolina and Tycksen, Eric and others}, title = {{Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy}}, journal = {Science Translational Medicine}, year = {2025}, doi = {10.1126/scitranslmed.adk3690}, pmid = {39813317}, url = {https://doi.org/10.1126/scitranslmed.adk3690} } @article{ulrich2016-26854967, author = {Ulrich, J. D. and Holtzman, D. M.}, title = {{TREM2 Function in Alzheimer's Disease and Neurodegeneration}}, journal = {ACS chemical neuroscience}, year = {2016}, doi = {10.1021/acschemneuro.5b00313}, pmid = {26854967}, url = {https://doi.org/10.1021/acschemneuro.5b00313} } @article{kober2020-33090700, author = {Kober, D. L. and Stuchell-Brereton, M. D. and Kluender, C. E. and Dean, H. B. and Strickland, M. R. and Steinberg, D. F. and Nelson, S. S. and Baban, B. and others}, title = {{Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2020}, doi = {10.1002/alz.12194}, pmid = {33090700}, url = {https://doi.org/10.1002/alz.12194} } @article{collij2025-41443949, author = {Collij, Lyduine Eisa and Salvadó, Gemma and Horie, Kanta and Barthélemy, Nicolas R. and Betthauser, Tobey J. and Strandberg, Olof T. and Smith, Ruben A and Palmqvist, Sebastian and others}, title = {{Trajectories of CSF and plasma MTBR‐tau 243 and phosphorylated‐tau species across the Alzheimer's disease continuum}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70856_098557}, pmid = {41443949}, url = {https://doi.org/10.1002/alz70856_098557} } @article{iyer2025-40527900, author = {Iyer, Abhirami Kannan and Vermunt, Lisa and Mirfakhar, Farzaneh Sadat and Minaya, Miguel and Acquarone, Mariana and Koppisetti, Rama K. and Renganathan, Arun and You, Shih‐Feng and others}, title = {{Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau}}, journal = {Molecular Psychiatry}, year = {2025}, doi = {10.1038/s41380-025-03073-2}, pmid = {40527900}, url = {https://doi.org/10.1038/s41380-025-03073-2} } @article{albanus2025-40737431, author = {Albanus, Ricardo D’Oliveira and Finan, Gina M. and Brase, Logan and Sweeney, Nicholas and Kim, Tae Yeon and Chen, Shuo and Ryoo, Yeonsu and others}, title = {{Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease}}, journal = {Science Translational Medicine}, year = {2025}, doi = {10.1126/scitranslmed.adx0027}, pmid = {40737431}, url = {https://doi.org/10.1126/scitranslmed.adx0027} } @article{lennol2025-40856646, author = {Lennol, Matthew Paul and Bordier, Chiara and Kamelher, Léana and Ulrich, Jason D. and Holtzman, David M. and Gratuze, Maud}, title = {{ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease}}, journal = {The Journal of Experimental Medicine}, year = {2025}, doi = {10.1084/jem.20250965}, pmid = {40856646}, url = {https://doi.org/10.1084/jem.20250965} } @article{strain2022-35358703, author = {Strain, J. F. and Barthelemy, N. and Horie, K. and Gordon, B. A. and Kilgore, C. and Aschenbrenner, A. and Cruchaga, C. and Xiong, C. and others}, title = {{CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease}}, journal = {Neurobiology of disease}, year = {2022}, doi = {10.1016/j.nbd.2022.105714}, pmid = {35358703}, url = {https://doi.org/10.1016/j.nbd.2022.105714} } @article{cash2025-40118731, author = {Cash, D. M. and Morgan, K. E. and O'Connor, A. and Veale, T. D. and Malone, I. B. and Poole, T. and Benzinger, T. L. and Gordon, B. A. and others}, title = {{Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100133}, pmid = {40118731}, url = {https://doi.org/10.1016/j.tjpad.2025.100133} } @article{schindler2023-35934777, author = {Schindler, S. E. and Li, Y. and Li, M. and Despotis, A. and Park, E. and Vittert, L. and Hamilton, B. H. and Womack, K. B. and others}, title = {{Using Alzheimer's disease blood tests to accelerate clinical trial enrollment}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.12754}, pmid = {35934777}, url = {https://doi.org/10.1002/alz.12754} } @article{kuszczyk2013-23499462, author = {Kuszczyk, M. A. and Sanchez, S. and Pankiewicz, J. and Kim, J. and Duszczyk, M. and Guridi, M. and Asuni, A. A. and Sullivan, P. M. and others}, title = {{Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration}}, journal = {The American journal of pathology}, year = {2013}, doi = {10.1016/j.ajpath.2013.01.034}, pmid = {23499462}, url = {https://doi.org/10.1016/j.ajpath.2013.01.034} } @article{li2018-29880032, author = {Li, Z. and Del-Aguila, J. L. and Dube, U. and Budde, J. and Martinez, R. and Black, K. and Xiao, Q. and Cairns, N. J. and others}, title = {{Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure}}, journal = {Genome medicine}, year = {2018}, doi = {10.1186/s13073-018-0551-4}, pmid = {29880032}, url = {https://doi.org/10.1186/s13073-018-0551-4} } @article{levine2022-34966024, author = {Levine, T. F. and Roe, C. M. and Babulal, G. M. and Fagan, A. M. and Head, D.}, title = {{Limited Longitudinal Change in Self-reported Spatial Navigation Ability in Preclinical Alzheimer Disease}}, journal = {Alzheimer disease and associated disorders}, year = {2022}, doi = {10.1097/wad.0000000000000487}, pmid = {34966024}, url = {https://doi.org/10.1097/wad.0000000000000487} } @article{patel2025-41442552, author = {Patel, Maulikkumar and Cetin, Arda and Johnson, Matthew and Ryan, Natalie Sarah and Budde, John and Liu, Menghan and Llibre‐Guerra, Jorge J. and Morris, John C. and others}, title = {{Identification of genetic modifiers influencing disease risk in autosomal dominant Alzheimer disease mutation carriers}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_105550}, pmid = {41442552}, url = {https://doi.org/10.1002/alz70855_105550} } @article{sirkis2019-31687268, author = {Sirkis, D. W. and Geier, E. G. and Bonham, L. W. and Karch, C. M. and Yokoyama, J. S.}, title = {{Recent advances in the genetics of frontotemporal dementia}}, journal = {Current genetic medicine reports}, year = {2019}, doi = {10.1007/s40142-019-0160-6}, pmid = {31687268}, url = {https://doi.org/10.1007/s40142-019-0160-6} } @article{bosch2026-41695615, author = {Bosch, Megan E. and Ulrich, Jason D.}, title = {{Spilling the T: T cells in tauopathy mechanisms, disease progression, and therapeutic horizons}}, journal = {Molecular Neurodegeneration Advances}, year = {2026}, doi = {10.1186/s44477-026-00020-5}, pmid = {41695615}, url = {https://doi.org/10.1186/s44477-026-00020-5} } @article{deming2018-3f7a9435, author = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others}, title = {{The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk}}, journal = {Science translational medicine}, year = {2018}, doi = {10.1101/352179}, url = {https://doi.org/10.1101/352179} } @article{lin2026-2a0fe361, author = {Lin, W. and Beric, A. and Wisch, J. K. and Baker, B. and Jerome, G. and Minton, M. and Preminger, S. and Stauber, J. and others}, title = {{Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer’s Disease}}, journal = {medRxiv}, year = {2026}, doi = {10.64898/2026.03.31.26349851}, url = {https://doi.org/10.64898/2026.03.31.26349851} }