% alzhub.org library filter % Source: https://alzhub.org/research?institution=I4210113080 % 151 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{blazhenets2026-42441390, author = {Blazhenets, Ganna and Soleimani-Meigooni, David N and Chiotis, Konstantinos and Allen, Isabel E and Rabinovici, Gil D and La Joie, Renaud and {Meta-Centiloid Study Group} and Apostolova, Liana G and others}, title = {{Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis}}, journal = {JAMA}, year = {2026}, doi = {10.1001/jama.2026.13116}, pmid = {42441390}, url = {https://doi.org/10.1001/jama.2026.13116} } @article{oh2025-40164724, author = {Oh, H. S. and Urey, D. Y. and Karlsson, L. and Zhu, Z. and Shen, Y. and Farinas, A. and Timsina, J. and Duggan, M. R. and others}, title = {{A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease}}, journal = {Nature medicine}, year = {2025}, doi = {10.1038/s41591-025-03565-2}, pmid = {40164724}, url = {https://doi.org/10.1038/s41591-025-03565-2} } @article{wagemann2024-38683602, author = {Wagemann, O. and Liu, H. and Wang, G. and Shi, X. and Bittner, T. and Scelsi, M. A. and Farlow, M. R. and Clifford, D. B. and others}, title = {{Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.0991}, pmid = {38683602}, url = {https://doi.org/10.1001/jamaneurol.2024.0991} } @article{rojas2021-33827960, author = {Rojas, J. C. and Wang, P. and Staffaroni, A. M. and Heller, C. and Cobigo, Y. and Wolf, A. and Goh, S. M. and Ljubenkov, P. A. and others}, title = {{Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011848}, pmid = {33827960}, url = {https://doi.org/10.1212/wnl.0000000000011848} } @article{jansen2022-36066633, author = {Jansen, I. E. and van der Lee, S. J. and Gomez-Fonseca, D. and de Rojas, I. and Dalmasso, M. C. and Grenier-Boley, B. and Zettergren, A. and Mishra, A. and others}, title = {{Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers}}, journal = {Acta neuropathologica}, year = {2022}, doi = {10.1007/s00401-022-02454-z}, pmid = {36066633}, url = {https://doi.org/10.1007/s00401-022-02454-z} } @article{morenasrodriguez2022-35305339, author = {Morenas-Rodríguez, E. and Li, Y. and Nuscher, B. and Franzmeier, N. and Xiong, C. and Suárez-Calvet, M. and Fagan, A. M. and Schultz, S. and others}, title = {{Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study}}, journal = {The Lancet. Neurology}, year = {2022}, doi = {10.1016/s1474-4422(22)00027-8}, pmid = {35305339}, url = {https://doi.org/10.1016/s1474-4422(22)00027-8} } @article{parhizkar2019-30617257, author = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others}, title = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-018-0296-9}, pmid = {30617257}, url = {https://doi.org/10.1038/s41593-018-0296-9} } @article{armstrong2020-32517579, author = {Armstrong, N. J. and Mather, K. A. and Sargurupremraj, M. and Knol, M. J. and Malik, R. and Satizabal, C. L. and Yanek, L. R. and Wen, W. and others}, title = {{Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities}}, journal = {Stroke}, year = {2020}, doi = {10.1161/strokeaha.119.027544}, pmid = {32517579}, url = {https://doi.org/10.1161/strokeaha.119.027544} } @article{broce2018-29315334, author = {Broce, I. and Karch, C. M. and Wen, N. and Fan, C. C. and Wang, Y. and Tan, C. H. and Kouri, N. and Ross, O. A. and others}, title = {{Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies}}, journal = {PLoS medicine}, year = {2018}, doi = {10.1371/journal.pmed.1002487}, pmid = {29315334}, url = {https://doi.org/10.1371/journal.pmed.1002487} } @article{suarezcalvet2019-30630532, author = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others}, title = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-018-0301-5}, pmid = {30630532}, url = {https://doi.org/10.1186/s13024-018-0301-5} } @article{zietemann2018-30333158, author = {Zietemann, V. and Georgakis, M. K. and Dondaine, T. and Müller, C. and Mendyk, A. M. and Kopczak, A. and Hénon, H. and Bombois, S. and others}, title = {{Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006506}, pmid = {30333158}, url = {https://doi.org/10.1212/wnl.0000000000006506} } @article{roemercassiano2025-39841807, author = {Roemer-Cassiano, S. N. and Wagner, F. and Evangelista, L. and Rauchmann, B. S. and Dehsarvi, A. and Steward, A. and Dewenter, A. and Biel, D. and Zhu, Z. and Pescoller, J. and Gross, M. and Perneczky, R. and others}, title = {{Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease}}, journal = {Science Translational Medicine}, year = {2025}, doi = {10.1126/scitranslmed.adp2564}, pmid = {39841807}, url = {https://doi.org/10.1126/scitranslmed.adp2564} } @article{wisch2024-38631766, author = {Wisch, J. K. and McKay, N. S. and Boerwinkle, A. H. and Kennedy, J. and Flores, S. and Handen, B. L. and Christian, B. T. and Head, E. and others}, title = {{Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2024}, doi = {10.1016/s1474-4422(24)00084-x}, pmid = {38631766}, url = {https://doi.org/10.1016/s1474-4422(24)00084-x} } @article{shirzadi2023-37843849, author = {Shirzadi, Z. and Schultz, S. A. and Yau, W. W. and Joseph-Mathurin, N. and Fitzpatrick, C. D. and Levin, R. and Kantarci, K. and Preboske, G. M. and others}, title = {{Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3618}, pmid = {37843849}, url = {https://doi.org/10.1001/jamaneurol.2023.3618} } @article{stark2023-37821235, author = {Stark, M. and Wolfsgruber, S. and Kleineidam, L. and Frommann, I. and Altenstein, S. and Bartels, C. and Brosseron, F. and Buerger, K. and others}, title = {{Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207844}, pmid = {37821235}, url = {https://doi.org/10.1212/wnl.0000000000207844} } @article{josephmathurin2022-36151869, author = {Joseph-Mathurin, N. and Llibre-Guerra, J. J. and Li, Y. and McCullough, A. A. and Hofmann, C. and Wojtowicz, J. and Park, E. and Wang, G. and others}, title = {{Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease}}, journal = {Annals of neurology}, year = {2022}, doi = {10.1002/ana.26511}, pmid = {36151869}, url = {https://doi.org/10.1002/ana.26511} } @article{mengel2025-40247130, author = {Mengel, D. and Soter, E. and Ott, J. M. and Wacker, M. and Leyva, A. and Peters, O. and Hellmann-Regen, J. and Schneider, L. S. and others}, title = {{Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease}}, journal = {Molecular psychiatry}, year = {2025}, doi = {10.1038/s41380-025-03021-0}, pmid = {40247130}, url = {https://doi.org/10.1038/s41380-025-03021-0} } @article{depp2023-37258678, author = {Depp, C. and Sun, T. and Sasmita, A. O. and Spieth, L. and Berghoff, S. A. and Nazarenko, T. and Overhoff, K. and Steixner-Kumar, A. A. and others}, title = {{Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease}}, journal = {Nature}, year = {2023}, doi = {10.1038/s41586-023-06120-6}, pmid = {37258678}, url = {https://doi.org/10.1038/s41586-023-06120-6} } @article{biel2021-34384484, author = {Biel, D. and Brendel, M. and Rubinski, A. and Buerger, K. and Janowitz, D. and Dichgans, M. and Franzmeier, N.}, title = {{Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00880-x}, pmid = {34384484}, url = {https://doi.org/10.1186/s13195-021-00880-x} } @article{luo2022-35925685, author = {Luo, J. and Agboola, F. and Grant, E. and Morris, J. C. and Masters, C. L. and Albert, M. S. and Johnson, S. C. and McDade, E. M. and others}, title = {{Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan}}, journal = {Brain : a journal of neurology}, year = {2022}, doi = {10.1093/brain/awac238}, pmid = {35925685}, url = {https://doi.org/10.1093/brain/awac238} } @article{steward2023-37930695, author = {Steward, A. and Biel, D. and Dewenter, A. and Roemer, S. and Wagner, F. and Dehsarvi, A. and Rathore, S. and Otero Svaldi, D. and others}, title = {{ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.4038}, pmid = {37930695}, url = {https://doi.org/10.1001/jamaneurol.2023.4038} } @article{kurz2022-34823269, author = {Kurz, C. and Walker, L. and Rauchmann, B. S. and Perneczky, R.}, title = {{Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies}}, journal = {Neuropathology and applied neurobiology}, year = {2022}, doi = {10.1111/nan.12782}, pmid = {34823269}, url = {https://doi.org/10.1111/nan.12782} } @article{llibreguerra2019-31825500, author = {Llibre-Guerra, J. J. and Li, Y. and Schindler, S. E. and Gordon, B. A. and Fagan, A. M. and Morris, J. C. and Benzinger, T. L. S. and Hassenstab, J. and others}, title = {{Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.17126}, pmid = {31825500}, url = {https://doi.org/10.1001/jamanetworkopen.2019.17126} } @article{wardlaw2013-23867200, author = {Wardlaw, Joanna Marguerite and Smith, Eric Edward and Biessels, Geert Jan and Cordonnier, Charlotte and Fazekas, Franz and Frayne, Richard and Lindley, Richard I. and O'Brien, John Tiernan and others}, title = {{Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration}}, journal = {The Lancet Neurology}, year = {2013}, doi = {10.1016/s1474-4422(13)70124-8}, pmid = {23867200}, url = {https://doi.org/10.1016/s1474-4422(13)70124-8} } @article{duering2023-37236211, author = {Duering, Marco and Biessels, Geert Jan and Brodtmann, Amy G. and Chen, Christopher and Cordonnier, Charlotte and de Leeuw, Frank‐Erik and Debette, Stéphanie and Frayne, Richard and Jouvent, Éric and Rost, Natalia S. and ter Telgte, Annemieke and Salman, Rustam Al‐Shahi and Backes, Walter H. and Bae, Hee‐Joon and Brown, Rosalind and Chabriat, Hugues and De Luca, Alberto and DeCarli, Charles S and Dewenter, Anna and Doubal, Fergus and Ewers, Michael and Field, Thalia Shoshana and Ganesh, Aravind and Greenberg, Steven Mark and Helmer, Karl G. and Hilal, Saima and Jochems, Angela C.C. and Jokinen, Hanna and Kuijf, Hugo J. and Lam, Bonnie Y. K. and Lebenberg, Jessica and MacIntosh, Bradley John and Maillard, Pauline and Mok, Vincent and Pantoni, Leonardo and Rudilosso, Salvatore and Satizábal, Claudia Liliana and Schirmer, Markus D. and Schmidt, Reinhold and Smith, Colin and Staals, Julie and Thrippleton, Michael J. and van Veluw, Susanne J. and Vemuri, Prashanthi and Wang, Yilong and Werring, David John and Zedde, Marialuisa and Akinyemi, Rufus and Del Brutto, Óscar H. and Markus, Hugh Stephen and Zhu, Yi‐Cheng and Smith, Eric Edward and Dichgans, Martin and Wardlaw, Joanna Marguerite}, title = {{Neuroimaging standards for research into small vessel disease—advances since 2013}}, journal = {The Lancet Neurology}, year = {2023}, doi = {10.1016/s1474-4422(23)00131-x}, pmid = {37236211}, url = {https://doi.org/10.1016/s1474-4422(23)00131-x} } @article{hofmann2024-39557867, author = {Hofmann, A. and Häsler, L. M. and Lambert, M. and Kaeser, S. A. and Gräber-Sultan, S. and Obermüller, U. and Kuder-Buletta, E. and la Fougere, C. and others}, title = {{Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease}}, journal = {Nature communications}, year = {2024}, doi = {10.1038/s41467-024-52937-8}, pmid = {39557867}, url = {https://doi.org/10.1038/s41467-024-52937-8} } @article{krasemann2017-28930663, author = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others}, title = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}}, journal = {Immunity}, year = {2017}, doi = {10.1016/j.immuni.2017.08.008}, pmid = {28930663}, url = {https://doi.org/10.1016/j.immuni.2017.08.008} } @article{sadlon2023-37787094, author = {Sadlon, A. and Takousis, P. and Ankli, B. and Alexopoulos, P. and Perneczky, R. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Association of Chronic Pain with Biomarkers of Neurodegeneration, Microglial Activation, and Inflammation in Cerebrospinal Fluid and Impaired Cognitive Function}}, journal = {Annals of neurology}, year = {2023}, doi = {10.1002/ana.26804}, pmid = {37787094}, url = {https://doi.org/10.1002/ana.26804} } @article{mirza2025-40260680, author = {Mirza, Saira Saeed and Pasternak, Maurice M. and Paterson, Andrew D. and Rogaeva, Ekaterina A. and Tartaglia, Maria Carmela and Mitchell, Sara Berman and Black, Sandra E. and Freedman, Morris and others}, title = {{Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study}}, journal = {Brain}, year = {2025}, doi = {10.1093/brain/awaf019}, pmid = {40260680}, url = {https://doi.org/10.1093/brain/awaf019} } @article{schultz2024-39074479, author = {Schultz, S. A. and Liu, L. and Schultz, A. P. and Fitzpatrick, C. D. and Levin, R. and Bellier, J. P. and Shirzadi, Z. and Joseph-Mathurin, N. and others}, title = {{γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)}}, journal = {The Lancet. Neurology}, year = {2024}, doi = {10.1016/s1474-4422(24)00236-9}, pmid = {39074479}, url = {https://doi.org/10.1016/s1474-4422(24)00236-9} } @article{study2020-32161412, author = {{the Dominantly Inherited Alzheimer Network} and Barthélemy, Nicolas R. and Li, Yan and Joseph‐Mathurin, Nelly and Gordon, Brian Andrew and Hassenstab, Jason J. and Benzinger, Tammie L.S. and Buckles, Virginia and Fagan, Anne M. and Perrin, Richard J. and Goate, Alison and Morris, John C. and Karch, Celeste M M. and Xiong, Chengjie and Allegri, Ricardo and Méndez, Patricio Chrem and Berman, Sarah B. and Ikeuchi, Takeshi and Mori, Hiroshi and Shimada, Hiroyuki and Shoji, Mikio and Suzuki, Kazushi and Noble, James McC. and Farlow, Martin Rhys and Chhatwal, Jasmeer P. and Graff‐Radford, Neill R. and Salloway, Stephen and Schofield, Peter R. and Masters, Colin Louis and Martins, Ralph Nigel and O’Connor, Antoinette and Fox, Nick C. and Levin, Johannes and Jucker, Mathias and Gabelle, Audrey and Lehmann, Sylvain and Sato, Chihiro and Bateman, Randall John and Bateman, Randall J. and McDade, Eric}, title = {{A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease}}, journal = {Nature Medicine}, year = {2020}, doi = {10.1038/s41591-020-0781-z}, pmid = {32161412}, url = {https://doi.org/10.1038/s41591-020-0781-z} } @article{fagan2021-34302786, author = {Fagan, A. M. and Henson, R. L. and Li, Y. and Boerwinkle, A. H. and Xiong, C. and Bateman, R. J. and Goate, A. and Ances, B. M. and others}, title = {{Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2021}, doi = {10.1016/s1474-4422(21)00139-3}, pmid = {34302786}, url = {https://doi.org/10.1016/s1474-4422(21)00139-3} } @article{franzmeier2020-33032659, author = {Franzmeier, N. and Suárez-Calvet, M. and Frontzkowski, L. and Moore, A. and Hohman, T. J. and Morenas-Rodriguez, E. and Nuscher, B. and Shaw, L. and others}, title = {{Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration}}, journal = {Molecular neurodegeneration}, year = {2020}, doi = {10.1186/s13024-020-00407-2}, pmid = {33032659}, url = {https://doi.org/10.1186/s13024-020-00407-2} } @article{filler2025-40893447, author = {Filler, Jule and Georgakis, Marios K. and Janowitz, Daniel and Duering, Marco and Fang, Rong and Dewenter, Anna and Bode, Felix Jürgen and Stoesser, Sebastian and others}, title = {{Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study}}, journal = {The Lancet Regional Health - Europe}, year = {2025}, doi = {10.1016/j.lanepe.2025.101428}, pmid = {40893447}, url = {https://doi.org/10.1016/j.lanepe.2025.101428} } @article{nicolas2025-40533518, author = {Nicolas, A. and Sherva, R. and Grenier-Boley, B. and Kim, Y. and Kikuchi, M. and Timsina, J. and de Rojas, I. and Dalmasso, M. C. and Zhou, X. and Le Guen, Y. and Arboleda-Bustos, C. E. and Camargos Bicalho, M. A. and others}, title = {{Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations}}, journal = {Nature genetics}, year = {2025}, doi = {10.1038/s41588-025-02227-w}, pmid = {40533518}, url = {https://doi.org/10.1038/s41588-025-02227-w} } @article{rost2022-35420911, author = {Rost, N. S. and Brodtmann, A. and Pase, M. P. and van Veluw, S. J. and Biffi, A. and Duering, M. and Hinman, J. D. and Dichgans, M.}, title = {{Post-Stroke Cognitive Impairment and Dementia}}, journal = {Circulation research}, year = {2022}, doi = {10.1161/circresaha.122.319951}, pmid = {35420911}, url = {https://doi.org/10.1161/circresaha.122.319951} } @article{malik2021-33749976, author = {Malik, R. and Georgakis, M. K. and Neitzel, J. and Rannikmäe, K. and Ewers, M. and Seshadri, S. and Sudlow, C. L. M. and Dichgans, M.}, title = {{Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2021}, doi = {10.1002/alz.12320}, pmid = {33749976}, url = {https://doi.org/10.1002/alz.12320} } @article{young2021-34158384, author = {Young, A. L. and Bocchetta, M. and Russell, L. L. and Convery, R. S. and Peakman, G. and Todd, E. and Cash, D. M. and Greaves, C. V. and others}, title = {{Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012410}, pmid = {34158384}, url = {https://doi.org/10.1212/wnl.0000000000012410} } @article{vanderlee2019-31131421, author = {van der Lee, S. J. and Conway, O. J. and Jansen, I. and Carrasquillo, M. M. and Kleineidam, L. and van den Akker, E. and Hernández, I. and van Eijk, K. R. and others}, title = {{A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity}}, journal = {Acta neuropathologica}, year = {2019}, doi = {10.1007/s00401-019-02026-8}, pmid = {31131421}, url = {https://doi.org/10.1007/s00401-019-02026-8} } @article{steward2026-41410687, author = {Steward, A. and Dewenter, A. and Hirsch, F. and Roemer-Cassiano, S. N. and Zhu, Z. and Dehsarvi, A. and Biel, D. and Klonowski, M. and Frontzkowski, L. and Palleis, C. and Gnörich, J. and Dichgans, M. and others}, title = {{ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner}}, journal = {Brain}, year = {2026}, doi = {10.1093/brain/awaf463}, pmid = {41410687}, url = {https://doi.org/10.1093/brain/awaf463} } @article{wardlaw2019-31097385, author = {Wardlaw, J. M. and Smith, C. and Dichgans, M.}, title = {{Small vessel disease: mechanisms and clinical implications}}, journal = {The Lancet. Neurology}, year = {2019}, doi = {10.1016/s1474-4422(19)30079-1}, pmid = {31097385}, url = {https://doi.org/10.1016/s1474-4422(19)30079-1} } @article{suarezcalvet2016-26941262, author = {Suárez-Calvet, M. and Kleinberger, G. and MÁ, Araque Caballero and Brendel, M. and Rominger, A. and Alcolea, D. and Fortea, J. and Lleó, A. and others}, title = {{sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers}}, journal = {EMBO molecular medicine}, year = {2016}, doi = {10.15252/emmm.201506123}, pmid = {26941262}, url = {https://doi.org/10.15252/emmm.201506123} } @article{ewers2020-32790063, author = {Ewers, M. and Biechele, G. and Suárez-Calvet, M. and Sacher, C. and Blume, T. and Morenas-Rodriguez, E. and Deming, Y. and Piccio, L. and others}, title = {{Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation}}, journal = {EMBO molecular medicine}, year = {2020}, doi = {10.15252/emmm.202012308}, pmid = {32790063}, url = {https://doi.org/10.15252/emmm.202012308} } @article{wardlaw2013-23602162, author = {Wardlaw, J. M. and Smith, C. and Dichgans, M.}, title = {{Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging}}, journal = {The Lancet. Neurology}, year = {2013}, doi = {10.1016/s1474-4422(13)70060-7}, pmid = {23602162}, url = {https://doi.org/10.1016/s1474-4422(13)70060-7} } @article{mori2013-23393093, author = {Mori, K. and Weng, S. M. and Arzberger, T. and May, S. and Rentzsch, K. and Kremmer, E. and Schmid, B. and Kretzschmar, H. A. and others}, title = {{The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS}}, journal = {Science (New York, N.Y.)}, year = {2013}, doi = {10.1126/science.1232927}, pmid = {23393093}, url = {https://doi.org/10.1126/science.1232927} } @article{willem2015-26322584, author = {Willem, M. and Tahirovic, S. and Busche, M. A. and Ovsepian, S. V. and Chafai, M. and Kootar, S. and Hornburg, D. and Evans, L. D. and others}, title = {{η-Secretase processing of APP inhibits neuronal activity in the hippocampus}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14864}, pmid = {26322584}, url = {https://doi.org/10.1038/nature14864} } @article{brosseron2022-34995486, author = {Brosseron, F. and Maass, A. and Kleineidam, L. and Ravichandran, K. A. and González, P. G. and McManus, R. M. and Ising, C. and Santarelli, F. and others}, title = {{Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease}}, journal = {Neuron}, year = {2022}, doi = {10.1016/j.neuron.2021.12.016}, pmid = {34995486}, url = {https://doi.org/10.1016/j.neuron.2021.12.016} } @article{luo2023-37195665, author = {Luo, J. and Thomassen, J. Q. and Bellenguez, C. and Grenier-Boley, B. and de Rojas, I. and Castillo, A. and Parveen, K. and others}, title = {{Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.13734}, pmid = {37195665}, url = {https://doi.org/10.1001/jamanetworkopen.2023.13734} } @article{lim2022-35099506, author = {Lim, Y. Y. and Maruff, P. and Barthélemy, N. R. and Goate, A. and Hassenstab, J. and Sato, C. and Fagan, A. M. and Benzinger, T. L. S. and others}, title = {{Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2021.5181}, pmid = {35099506}, url = {https://doi.org/10.1001/jamaneurol.2021.5181} } @article{kleinberger2014-24990881, author = {Kleinberger, G. and Yamanishi, Y. and Suárez-Calvet, M. and Czirr, E. and Lohmann, E. and Cuyvers, E. and Struyfs, H. and Pettkus, N. and others}, title = {{TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis}}, journal = {Science translational medicine}, year = {2014}, doi = {10.1126/scitranslmed.3009093}, pmid = {24990881}, url = {https://doi.org/10.1126/scitranslmed.3009093} } @article{zhang2016-26998601, author = {Zhang, Y. J. and Gendron, T. F. and Grima, J. C. and Sasaguri, H. and Jansen-West, K. and Xu, Y. F. and Katzman, R. B. and Gass, J. and others}, title = {{C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins}}, journal = {Nature neuroscience}, year = {2016}, doi = {10.1038/nn.4272}, pmid = {26998601}, url = {https://doi.org/10.1038/nn.4272} } @article{chew2015-25977373, author = {Chew, J. and Gendron, T. F. and Prudencio, M. and Sasaguri, H. and Zhang, Y. J. and Castanedes-Casey, M. and Lee, C. W. and Jansen-West, K. and others}, title = {{Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits}}, journal = {Science (New York, N.Y.)}, year = {2015}, doi = {10.1126/science.aaa9344}, pmid = {25977373}, url = {https://doi.org/10.1126/science.aaa9344} } @article{xiang2021-34644146, author = {Xiang, X. and Wind, K. and Wiedemann, T. and Blume, T. and Shi, Y. and Briel, N. and Beyer, L. and Biechele, G. and others}, title = {{Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases}}, journal = {Science translational medicine}, year = {2021}, doi = {10.1126/scitranslmed.abe5640}, pmid = {34644146}, url = {https://doi.org/10.1126/scitranslmed.abe5640} } @article{biel2023-36620941, author = {Biel, D. and Suárez-Calvet, M. and Hager, P. and Rubinski, A. and Dewenter, A. and Steward, A. and Roemer, S. and Ewers, M. and others}, title = {{sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease}}, journal = {EMBO molecular medicine}, year = {2023}, doi = {10.15252/emmm.202216987}, pmid = {36620941}, url = {https://doi.org/10.15252/emmm.202216987} } @article{heller2020-31937580, author = {Heller, C. and Foiani, M. S. and Moore, K. and Convery, R. and Bocchetta, M. and Neason, M. and Cash, D. M. and Thomas, D. and others}, title = {{Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2020}, doi = {10.1136/jnnp-2019-321954}, pmid = {31937580}, url = {https://doi.org/10.1136/jnnp-2019-321954} } @article{soriano2025-40528393, author = {Soriano, Laura del Hoyo and Sandkühler, Katja and Videla, Laura and Benejam, Bessy and Carmona‐Iragui, María and Wlasich, Elisabeth and Kustermann, Julia and Barroeta, Isabel and others}, title = {{Discrepancies in assessing intellectual disability levels in adults with Down syndrome: Implications for dementia diagnosis}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70307}, pmid = {40528393}, url = {https://doi.org/10.1002/alz.70307} } @article{morris2022-35580594, author = {Morris, J. C. and Weiner, M. and Xiong, C. and Beckett, L. and Coble, D. and Saito, N. and Aisen, P. S. and Allegri, R. and others}, title = {{Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology}}, journal = {Brain : a journal of neurology}, year = {2022}, doi = {10.1093/brain/awac181}, pmid = {35580594}, url = {https://doi.org/10.1093/brain/awac181} } @article{ballweg2023-36906584, author = {Ballweg, A. and Klaus, C. and Vogler, L. and Katzdobler, S. and Wind, K. and Zatcepin, A. and Ziegler, S. I. and Secgin, B. and others}, title = {{[18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data}}, journal = {Journal of neuroinflammation}, year = {2023}, doi = {10.1186/s12974-023-02749-2}, pmid = {36906584}, url = {https://doi.org/10.1186/s12974-023-02749-2} } @article{hachinski2019-31327392, author = {Hachinski, V. and Einhäupl, K. and Ganten, D. and Alladi, S. and Brayne, C. and Stephan, B. C. M. and Sweeney, M. D. and Zlokovic, B. and others}, title = {{Preventing dementia by preventing stroke: The Berlin Manifesto}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.06.001}, pmid = {31327392}, url = {https://doi.org/10.1016/j.jalz.2019.06.001} } @article{oeckl2022-35340050, author = {Oeckl, P. and Wagemann, O. and Halbgebauer, S. and Anderl-Straub, S. and Nuebling, G. and Prix, C. and Loosli, S. V. and Wlasich, E. and others}, title = {{Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181}}, journal = {Annals of neurology}, year = {2022}, doi = {10.1002/ana.26360}, pmid = {35340050}, url = {https://doi.org/10.1002/ana.26360} } @article{mazaheri2017-28483841, author = {Mazaheri, F. and Snaidero, N. and Kleinberger, G. and Madore, C. and Daria, A. and Werner, G. and Krasemann, S. and Capell, A. and others}, title = {{TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury}}, journal = {EMBO reports}, year = {2017}, doi = {10.15252/embr.201743922}, pmid = {28483841}, url = {https://doi.org/10.15252/embr.201743922} } @article{safaiyan2021-33606969, author = {Safaiyan, S. and Besson-Girard, S. and Kaya, T. and Cantuti-Castelvetri, L. and Liu, L. and Ji, H. and Schifferer, M. and Gouna, G. and others}, title = {{White matter aging drives microglial diversity}}, journal = {Neuron}, year = {2021}, doi = {10.1016/j.neuron.2021.01.027}, pmid = {33606969}, url = {https://doi.org/10.1016/j.neuron.2021.01.027} } @article{ali2022-35617280, author = {Ali, M. and Sung, Y. J. and Wang, F. and Fernández, M. V. and Morris, J. C. and Fagan, A. M. and Blennow, K. and Zetterberg, H. and others}, title = {{Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk}}, journal = {PloS one}, year = {2022}, doi = {10.1371/journal.pone.0267298}, pmid = {35617280}, url = {https://doi.org/10.1371/journal.pone.0267298} } @article{dichgans2017-28154105, author = {Dichgans, M. and Leys, D.}, title = {{Vascular Cognitive Impairment}}, journal = {Circulation research}, year = {2017}, doi = {10.1161/circresaha.116.308426}, pmid = {28154105}, url = {https://doi.org/10.1161/circresaha.116.308426} } @article{suarezcalvet2016-27974666, author = {Suárez-Calvet, M. and MÁ, Araque Caballero and Kleinberger, G. and Bateman, R. J. and Fagan, A. M. and Morris, J. C. and Levin, J. and Danek, A. and others}, title = {{Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury}}, journal = {Science translational medicine}, year = {2016}, doi = {10.1126/scitranslmed.aag1767}, pmid = {27974666}, url = {https://doi.org/10.1126/scitranslmed.aag1767} } @article{vanlengerich2023-36635496, author = {van Lengerich, B. and Zhan, L. and Xia, D. and Chan, D. and Joy, D. and Park, J. I. and Tatarakis, D. and Calvert, M. and others}, title = {{A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models}}, journal = {Nature neuroscience}, year = {2023}, doi = {10.1038/s41593-022-01240-0}, pmid = {36635496}, url = {https://doi.org/10.1038/s41593-022-01240-0} } @article{ma2018-30239611, author = {MÁ, Araque Caballero and Suárez-Calvet, M. and Duering, M. and Franzmeier, N. and Benzinger, T. and Fagan, A. M. and Bateman, R. J. and Jack, C. R. and others}, title = {{White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2018}, doi = {10.1093/brain/awy229}, pmid = {30239611}, url = {https://doi.org/10.1093/brain/awy229} } @article{sogorbesteve2025-39908349, author = {Sogorb‐Esteve, Aitana and Weiner, Sophia and Simrén, Joel and Swift, Imogen J. and Bocchetta, Martina and Todd, Emily G. and Cash, David M. and Bouzigues, Arabella and others}, title = {{Proteomic analysis reveals distinct cerebrospinal fluid signatures across genetic frontotemporal dementia subtypes}}, journal = {Science Translational Medicine}, year = {2025}, doi = {10.1126/scitranslmed.adm9654}, pmid = {39908349}, url = {https://doi.org/10.1126/scitranslmed.adm9654} } @article{deming2019-31413141, author = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others}, title = {{The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk}}, journal = {Science translational medicine}, year = {2019}, doi = {10.1126/scitranslmed.aau2291}, pmid = {31413141}, url = {https://doi.org/10.1126/scitranslmed.aau2291} } @article{rauchmann2022-36053756, author = {Rauchmann, B. S. and Brendel, M. and Franzmeier, N. and Trappmann, L. and Zaganjori, M. and Ersoezlue, E. and Morenas-Rodriguez, E. and Guersel, S. and others}, title = {{Microglial Activation and Connectivity in Alzheimer Disease and Aging}}, journal = {Annals of neurology}, year = {2022}, doi = {10.1002/ana.26465}, pmid = {36053756}, url = {https://doi.org/10.1002/ana.26465} } @article{bernhardt2025-40528443, author = {Bernhardt, A. M. and Í, Rodríguez-Baz and Aldecoa, I. and Arranz, J. and Arriola-Infante, J. E. and Maure-Blesa, L. and Carmona-Iragui, M. and Longen, S. and others}, title = {{Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70342}, pmid = {40528443}, url = {https://doi.org/10.1002/alz.70342} } @article{hofweber2018-29677514, author = {Hofweber, M. and Hutten, S. and Bourgeois, B. and Spreitzer, E. and Niedner-Boblenz, A. and Schifferer, M. and Ruepp, M. D. and Simons, M. and others}, title = {{Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation}}, journal = {Cell}, year = {2018}, doi = {10.1016/j.cell.2018.03.004}, pmid = {29677514}, url = {https://doi.org/10.1016/j.cell.2018.03.004} } @article{jiang2016-27112497, author = {Jiang, J. and Zhu, Q. and Gendron, T. F. and Saberi, S. and McAlonis-Downes, M. and Seelman, A. and Stauffer, J. E. and Jafar-Nejad, P. and others}, title = {{Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs}}, journal = {Neuron}, year = {2016}, doi = {10.1016/j.neuron.2016.04.006}, pmid = {27112497}, url = {https://doi.org/10.1016/j.neuron.2016.04.006} } @article{mori2013-24132570, author = {Mori, K. and Arzberger, T. and Grässer, F. A. and Gijselinck, I. and May, S. and Rentzsch, K. and Weng, S. M. and Schludi, M. H. and others}, title = {{Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins}}, journal = {Acta neuropathologica}, year = {2013}, doi = {10.1007/s00401-013-1189-3}, pmid = {24132570}, url = {https://doi.org/10.1007/s00401-013-1189-3} } @article{schlepckow2020-32154671, author = {Schlepckow, K. and Monroe, K. M. and Kleinberger, G. and Cantuti-Castelvetri, L. and Parhizkar, S. and Xia, D. and Willem, M. and Werner, G. and others}, title = {{Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region}}, journal = {EMBO molecular medicine}, year = {2020}, doi = {10.15252/emmm.201911227}, pmid = {32154671}, url = {https://doi.org/10.15252/emmm.201911227} } @article{gouna2021-34424266, author = {Gouna, G. and Klose, C. and Bosch-Queralt, M. and Liu, L. and Gokce, O. and Schifferer, M. and Cantuti-Castelvetri, L. and Simons, M.}, title = {{TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination}}, journal = {The Journal of experimental medicine}, year = {2021}, doi = {10.1084/jem.20210227}, pmid = {34424266}, url = {https://doi.org/10.1084/jem.20210227} } @article{schlepckow2023-37863592, author = {Schlepckow, K. and Morenas-Rodríguez, E. and Hong, S. and Haass, C.}, title = {{Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease}}, journal = {The Lancet. Neurology}, year = {2023}, doi = {10.1016/s1474-4422(23)00247-8}, pmid = {37863592}, url = {https://doi.org/10.1016/s1474-4422(23)00247-8} } @article{mackenzie2013-24096617, author = {Mackenzie, I. R. and Arzberger, T. and Kremmer, E. and Troost, D. and Lorenzl, S. and Mori, K. and Weng, S. M. and Haass, C. and others}, title = {{Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations}}, journal = {Acta neuropathologica}, year = {2013}, doi = {10.1007/s00401-013-1181-y}, pmid = {24096617}, url = {https://doi.org/10.1007/s00401-013-1181-y} } @article{biel2025-41126448, author = {Biel, Davina and Steward, Anna and Dewenter, Anna and Dehsarvi, Amir and Zhu, Zeyu and Roemer, Sebastian Niclas and Frontzkowski, Lukas K. and Hirsch, Fabian and others}, title = {{A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70783}, pmid = {41126448}, url = {https://doi.org/10.1002/alz.70783} } @article{biechele2022-34016733, author = {Biechele, G. and Monasor, L. S. and Wind, K. and Blume, T. and Parhizkar, S. and Arzberger, T. and Sacher, C. and Beyer, L. and others}, title = {{Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease}}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year = {2022}, doi = {10.2967/jnumed.120.261858}, pmid = {34016733}, url = {https://doi.org/10.2967/jnumed.120.261858} } @article{ewers2019-31462511, author = {Ewers, M. and Franzmeier, N. and Suárez-Calvet, M. and Morenas-Rodriguez, E. and Caballero, M. A. A. and Kleinberger, G. and Piccio, L. and Cruchaga, C. and others}, title = {{Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease}}, journal = {Science translational medicine}, year = {2019}, doi = {10.1126/scitranslmed.aav6221}, pmid = {31462511}, url = {https://doi.org/10.1126/scitranslmed.aav6221} } @article{schlepckow2017-28855300, author = {Schlepckow, K. and Kleinberger, G. and Fukumori, A. and Feederle, R. and Lichtenthaler, S. F. and Steiner, H. and Haass, C.}, title = {{An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function}}, journal = {EMBO molecular medicine}, year = {2017}, doi = {10.15252/emmm.201707672}, pmid = {28855300}, url = {https://doi.org/10.15252/emmm.201707672} } @article{kleinberger2017-28559417, author = {Kleinberger, G. and Brendel, M. and Mracsko, E. and Wefers, B. and Groeneweg, L. and Xiang, X. and Focke, C. and Deußing, M. and others}, title = {{The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism}}, journal = {The EMBO journal}, year = {2017}, doi = {10.15252/embj.201796516}, pmid = {28559417}, url = {https://doi.org/10.15252/embj.201796516} } @article{rauchmann2019-30458365, author = {Rauchmann, B. S. and Schneider-Axmann, T. and Alexopoulos, P. and Perneczky, R. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum}}, journal = {Neurobiology of aging}, year = {2019}, doi = {10.1016/j.neurobiolaging.2018.10.022}, pmid = {30458365}, url = {https://doi.org/10.1016/j.neurobiolaging.2018.10.022} } @article{dincer2020-33395982, author = {Dincer, A. and Gordon, B. A. and Hari-Raj, A. and Keefe, S. J. and Flores, S. and McKay, N. S. and Paulick, A. M. and Shady Lewis, K. E. and others}, title = {{Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease}}, journal = {NeuroImage. Clinical}, year = {2020}, doi = {10.1016/j.nicl.2020.102491}, pmid = {33395982}, url = {https://doi.org/10.1016/j.nicl.2020.102491} } @article{vassar2014-24646365, author = {Vassar, R. and Kuhn, P. H. and Haass, C. and Kennedy, M. E. and Rajendran, L. and Wong, P. C. and Lichtenthaler, S. F.}, title = {{Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects}}, journal = {Journal of neurochemistry}, year = {2014}, doi = {10.1111/jnc.12715}, pmid = {24646365}, url = {https://doi.org/10.1111/jnc.12715} } @article{lewcock2020-33096024, author = {Lewcock, J. W. and Schlepckow, K. and Di Paolo, G. and Tahirovic, S. and Monroe, K. M. and Haass, C.}, title = {{Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease}}, journal = {Neuron}, year = {2020}, doi = {10.1016/j.neuron.2020.09.029}, pmid = {33096024}, url = {https://doi.org/10.1016/j.neuron.2020.09.029} } @article{gruijsdasilva2022-35112738, author = {Gruijs da Silva, L. A. and Simonetti, F. and Hutten, S. and Riemenschneider, H. and Sternburg, E. L. and Pietrek, L. M. and Gebel, J. and Dötsch, V. and others}, title = {{Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation}}, journal = {The EMBO journal}, year = {2022}, doi = {10.15252/embj.2021108443}, pmid = {35112738}, url = {https://doi.org/10.15252/embj.2021108443} } @article{baumeister2025-40691867, author = {Baumeister, Hannah and Gellersen, Helena Marie and Polk, Sarah E. and Lattmann, René and Wuestefeld, Anika and Wisse, Laura E.M. and Glenn, Trevor W. and Yakupov, Renat and others}, title = {{Disease stage–specific atrophy markers in Alzheimer's disease}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70482}, pmid = {40691867}, url = {https://doi.org/10.1002/alz.70482} } @article{liu2025-40277074, author = {Liu, Xulin and de Boer, Sterre C.M. and Cortez, Kasey and Poos, Jackie M. and Illán‐Gala, Ignacio and Heuer, Hilary W. and Forsberg, Leah K. and Casaletto, Kaitlin Blackstone and others}, title = {{Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.14608}, pmid = {40277074}, url = {https://doi.org/10.1002/alz.14608} } @article{schultz2023-37291760, author = {Schultz, S. A. and Shirzadi, Z. and Schultz, A. P. and Liu, L. and Fitzpatrick, C. D. and McDade, E. and Barthelemy, N. R. and Renton, A. and others}, title = {{Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease}}, journal = {Aging cell}, year = {2023}, doi = {10.1111/acel.13871}, pmid = {37291760}, url = {https://doi.org/10.1111/acel.13871} } @article{zheng2024-37837382, author = {Zheng, L. and Rubinski, A. and Denecke, J. and Luan, Y. and Smith, R. and Strandberg, O. and Stomrud, E. and Ossenkoppele, R. and others}, title = {{Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease}}, journal = {Annals of neurology}, year = {2024}, doi = {10.1002/ana.26818}, pmid = {37837382}, url = {https://doi.org/10.1002/ana.26818} } @article{mackenzie2015-26374446, author = {Mackenzie, I. R. and Frick, P. and Grässer, F. A. and Gendron, T. F. and Petrucelli, L. and Cashman, N. R. and Edbauer, D. and Kremmer, E. and others}, title = {{Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers}}, journal = {Acta neuropathologica}, year = {2015}, doi = {10.1007/s00401-015-1476-2}, pmid = {26374446}, url = {https://doi.org/10.1007/s00401-015-1476-2} } @article{wagemann2026-42679336, author = {Wagemann, O. and Nuebling, G. S. and Sandkühler, K. and Wlasich, E. and Loosli, S. V. and Prix, C. and Stockbauer, A. C. and Marth, L. and others}, title = {{Longitudinal Dynamics of the Blood Proteome Within the Alzheimer Spectrum in Down Syndrome}}, journal = {Neurology}, year = {2026}, doi = {10.1212/wnl.0000000000218494}, pmid = {42679336}, url = {https://doi.org/10.1212/wnl.0000000000218494} } @article{guo2018-29398115, author = {Guo, Q. and Lehmer, C. and Martínez-Sánchez, A. and Rudack, T. and Beck, F. and Hartmann, H. and Pérez-Berlanga, M. and Frottin, F. and others}, title = {{In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment}}, journal = {Cell}, year = {2018}, doi = {10.1016/j.cell.2017.12.030}, pmid = {29398115}, url = {https://doi.org/10.1016/j.cell.2017.12.030} } @article{xiang2018-30185230, author = {Xiang, X. and Piers, T. M. and Wefers, B. and Zhu, K. and Mallach, A. and Brunner, B. and Kleinberger, G. and Song, W. and others}, title = {{The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans}}, journal = {Molecular neurodegeneration}, year = {2018}, doi = {10.1186/s13024-018-0280-6}, pmid = {30185230}, url = {https://doi.org/10.1186/s13024-018-0280-6} } @article{mcdade2021-34548654, author = {McDade, E. and Voytyuk, I. and Aisen, P. and Bateman, R. J. and Carrillo, M. C. and De Strooper, B. and Haass, C. and Reiman, E. M. and others}, title = {{The case for low-level BACE1 inhibition for the prevention of Alzheimer disease}}, journal = {Nature reviews. Neurology}, year = {2021}, doi = {10.1038/s41582-021-00545-1}, pmid = {34548654}, url = {https://doi.org/10.1038/s41582-021-00545-1} } @article{gotzl2019-31122931, author = {Götzl, J. K. and Brendel, M. and Werner, G. and Parhizkar, S. and Sebastian Monasor, L. and Kleinberger, G. and Colombo, A. V. and Deussing, M. and others}, title = {{Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism}}, journal = {EMBO molecular medicine}, year = {2019}, doi = {10.15252/emmm.201809711}, pmid = {31122931}, url = {https://doi.org/10.15252/emmm.201809711} } @article{gispert2016-27423963, author = {Gispert, J. D. and Suárez-Calvet, M. and Monté, G. C. and Tucholka, A. and Falcon, C. and Rojas, S. and Rami, L. and Sánchez-Valle, R. and others}, title = {{Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2016}, doi = {10.1016/j.jalz.2016.06.005}, pmid = {27423963}, url = {https://doi.org/10.1016/j.jalz.2016.06.005} } @article{reifschneider2022-35019161, author = {Reifschneider, A. and Robinson, S. and van Lengerich, B. and Gnörich, J. and Logan, T. and Heindl, S. and Vogt, M. A. and Weidinger, E. and others}, title = {{Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency}}, journal = {The EMBO journal}, year = {2022}, doi = {10.15252/embj.2021109108}, pmid = {35019161}, url = {https://doi.org/10.15252/embj.2021109108} } @article{yu2024-38289348, author = {Yu, C. and Lad, E. M. and Mathew, R. and Shiraki, N. and Littleton, S. and Chen, Y. and Hou, J. and Schlepckow, K. and others}, title = {{Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2}}, journal = {The Journal of experimental medicine}, year = {2024}, doi = {10.1084/jem.20231011}, pmid = {38289348}, url = {https://doi.org/10.1084/jem.20231011} } @article{schirge2025-40098158, author = {Schirge, P. M. and Perneczky, R. and Taoka, T. and Ruiz-Rizzo, A. L. and Ersoezlue, E. and Forbrig, R. and Guersel, S. and Kurz, C. and others}, title = {{Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-025-01707-9}, pmid = {40098158}, url = {https://doi.org/10.1186/s13195-025-01707-9} } @article{malik2021-34626176, author = {Malik, R. and Beaufort, N. and Frerich, S. and Gesierich, B. and Georgakis, M. K. and Rannikmäe, K. and Ferguson, A. C. and Haffner, C. and others}, title = {{Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities}}, journal = {Brain : a journal of neurology}, year = {2021}, doi = {10.1093/brain/awab253}, pmid = {34626176}, url = {https://doi.org/10.1093/brain/awab253} } @article{blujdea2026-41814022, author = {Blujdea, Elena Raluca and van Bokhoven, Pieter and Adami, Pamela V. Martino and Marshe, Victoria S. and Vromen, Ellen and Hok-A-Hin, Yanaika Sylvana and Boiten, Walter A. and Irwin, David John and others}, title = {{Microglia protein profiles in CSF across Alzheimer’s disease clinical stages}}, journal = {Nature Aging}, year = {2026}, doi = {10.1038/s43587-026-01088-0}, pmid = {41814022}, url = {https://doi.org/10.1038/s43587-026-01088-0} } @article{cetindag2026-41905188, author = {Cetindag, A. C. and Schipke, C. G. and Esselmann, H. and Kruse, N. and Wiltfang, J. and Schneider, A. and Fliessbach, K. and Miklitz, C. and others}, title = {{Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100544}, pmid = {41905188}, url = {https://doi.org/10.1016/j.tjpad.2026.100544} } @article{thomassen2026-42736378, author = {Thomassen, J. Q. and Leonard, H. and Ulms, B. and Grenier-Boley, B. and Heikkinen, S. and Garcia-González, P. and Castillo-Morales, A. and Kikuchi, M. and Gim, J. and Cao, H. and Küçükali, F. and Amin, N. and others}, title = {{APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease}}, journal = {Nature genetics}, year = {2026}, doi = {10.1038/s41588-026-02713-9}, pmid = {42736378}, url = {https://doi.org/10.1038/s41588-026-02713-9} } @article{franzmeier2017-28188306, author = {Franzmeier, N. and Duering, M. and Weiner, M. and Dichgans, M. and Ewers, M.}, title = {{Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000003711}, pmid = {28188306}, url = {https://doi.org/10.1212/wnl.0000000000003711} } @article{focke2019-30262517, author = {Focke, C. and Blume, T. and Zott, B. and Shi, Y. and Deussing, M. and Peters, F. and Schmidt, C. and Kleinberger, G. and others}, title = {{Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice}}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year = {2019}, doi = {10.2967/jnumed.118.217703}, pmid = {30262517}, url = {https://doi.org/10.2967/jnumed.118.217703} } @article{rother2022-36443293, author = {Rother, C. and Uhlmann, R. E. and Müller, S. A. and Schelle, J. and Skodras, A. and Obermüller, U. and Häsler, L. M. and Lambert, M. and others}, title = {{Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae}}, journal = {Nature communications}, year = {2022}, doi = {10.1038/s41467-022-34538-5}, pmid = {36443293}, url = {https://doi.org/10.1038/s41467-022-34538-5} } @article{gomes2019-31414210, author = {Gomes, L. A. and Hipp, S. A. and Rijal Upadhaya, A. and Balakrishnan, K. and Ospitalieri, S. and Koper, M. J. and Largo-Barrientos, P. and Uytterhoeven, V. and others}, title = {{Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein}}, journal = {Acta neuropathologica}, year = {2019}, doi = {10.1007/s00401-019-02053-5}, pmid = {31414210}, url = {https://doi.org/10.1007/s00401-019-02053-5} } @article{piollet2024-38974464, author = {Piollet, M. and Porsch, F. and Rizzo, G. and Kapser, F. and Schulz, D. J. J. and Kiss, M. G. and Schlepckow, K. and Morenas-Rodriguez, E. and others}, title = {{TREM2 protects from atherosclerosis by limiting necrotic core formation}}, journal = {Nature cardiovascular research}, year = {2024}, doi = {10.1038/s44161-024-00429-9}, pmid = {38974464}, url = {https://doi.org/10.1038/s44161-024-00429-9} } @article{brendel2017-28197095, author = {Brendel, M. and Kleinberger, G. and Probst, F. and Jaworska, A. and Overhoff, F. and Blume, T. and Albert, N. L. and Carlsen, J. and others}, title = {{Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00008}, pmid = {28197095}, url = {https://doi.org/10.3389/fnagi.2017.00008} } @article{liu2025-40605462, author = {Liu, Ella and Jones, Sherri Lee and Light, Victoria A. and Teunissen, Charlotte Elisabeth and Bouzigues, Arabella and Russell, Lucy Louise and Foster, Phoebe H. and Ferry‐Bolder, Eve and others}, title = {{Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251352103}, pmid = {40605462}, url = {https://doi.org/10.1177/13872877251352103} } @article{kurz2025-40314736, author = {Kurz, Carolin and De Carli, Laura and Gürsel, Selim Üstün and Schrurs, Isabelle and Jethwa, Alexander and Carboni, Margherita and Bittner, Tobias and Hortsch, Sayuri and others}, title = {{Plasma biomarkers of amyloid, tau \& neuroinflammation in Alzheimer’s disease and corticobasal syndrome}}, journal = {European Archives of Psychiatry and Clinical Neuroscience}, year = {2025}, doi = {10.1007/s00406-025-02013-z}, pmid = {40314736}, url = {https://doi.org/10.1007/s00406-025-02013-z} } @article{franzmeier2021-30899092, author = {Franzmeier, N. and Ren, J. and Damm, A. and Monté-Rubio, G. and Boada, M. and Ruiz, A. and Ramirez, A. and Jessen, F. and others}, title = {{The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2021}, doi = {10.1038/s41380-019-0404-6}, pmid = {30899092}, url = {https://doi.org/10.1038/s41380-019-0404-6} } @article{guner2020-32616437, author = {Güner, G. and Lichtenthaler, S. F.}, title = {{The substrate repertoire of γ-secretase/presenilin}}, journal = {Seminars in cell \& developmental biology}, year = {2020}, doi = {10.1016/j.semcdb.2020.05.019}, pmid = {32616437}, url = {https://doi.org/10.1016/j.semcdb.2020.05.019} } @article{xiang2016-27402340, author = {Xiang, X. and Werner, G. and Bohrmann, B. and Liesz, A. and Mazaheri, F. and Capell, A. and Feederle, R. and Knuesel, I. and others}, title = {{TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance}}, journal = {EMBO molecular medicine}, year = {2016}, doi = {10.15252/emmm.201606370}, pmid = {27402340}, url = {https://doi.org/10.15252/emmm.201606370} } @article{suarezcalvet2018-30482868, author = {Suárez-Calvet, M. and Capell, A. and MÁ, Araque Caballero and Morenas-Rodríguez, E. and Fellerer, K. and Franzmeier, N. and Kleinberger, G. and Eren, E. and others}, title = {{CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline}}, journal = {EMBO molecular medicine}, year = {2018}, doi = {10.15252/emmm.201809712}, pmid = {30482868}, url = {https://doi.org/10.15252/emmm.201809712} } @article{rauchmann2020-32368960, author = {Rauchmann, B. S. and Ghaseminejad, F. and Mekala, S. and Perneczky, R. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Cerebral Microhemorrhage at MRI in Mild Cognitive Impairment and Early Alzheimer Disease: Association with Tau and Amyloid β at PET Imaging}}, journal = {Radiology}, year = {2020}, doi = {10.1148/radiol.2020191904}, pmid = {32368960}, url = {https://doi.org/10.1148/radiol.2020191904} } @article{hillerstrom2024-38480678, author = {Hillerstrom, Hampus and Fisher, Richard Alan and Janicki, Matthew P. and Chicoine, Brian Allen and Christian, Bradley T. and Esbensen, Anna J. and Esralew, Lucille and Fortea, Juan and others}, title = {{Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome}}, journal = {Alzheimer s \& Dementia}, year = {2024}, doi = {10.1002/alz.13778}, pmid = {38480678}, url = {https://doi.org/10.1002/alz.13778} } @article{chen2025-40459787, author = {Chen, Charles D. and Franklin, Erin E. and Li, Yan and Joseph‐Mathurin, Nelly and Burns, Aime and Hobbs, Diana A. and McCullough, Austin A. and Schultz, Stephanie A. and others}, title = {{Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease}}, journal = {Acta Neuropathologica}, year = {2025}, doi = {10.1007/s00401-025-02890-7}, pmid = {40459787}, url = {https://doi.org/10.1007/s00401-025-02890-7} } @article{soltaninejad2025-41057914, author = {Soltaninejad, Mahdie and Dadar, Mahsa and Collins, D. Louis and Rajabli, Reza and Venkatraghavan, Vikram and Bouzigues, Arabella and Russell, Lucy Louise and Foster, Phoebe H. and others}, title = {{White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70695}, pmid = {41057914}, url = {https://doi.org/10.1002/alz.70695} } @article{biechele2021-33385560, author = {Biechele, G. and Wind, K. and Blume, T. and Sacher, C. and Beyer, L. and Eckenweber, F. and Franzmeier, N. and Ewers, M. and others}, title = {{Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice}}, journal = {NeuroImage}, year = {2021}, doi = {10.1016/j.neuroimage.2020.117707}, pmid = {33385560}, url = {https://doi.org/10.1016/j.neuroimage.2020.117707} } @article{karch2018-29630712, author = {Karch, C. M. and Wen, N. and Fan, C. C. and Yokoyama, J. S. and Kouri, N. and Ross, O. A. and Höglinger, G. and Müller, U. and others}, title = {{Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2018.0372}, pmid = {29630712}, url = {https://doi.org/10.1001/jamaneurol.2018.0372} } @article{takalo2020-32917267, author = {Takalo, M. and Wittrahm, R. and Wefers, B. and Parhizkar, S. and Jokivarsi, K. and Kuulasmaa, T. and Mäkinen, P. and Martiskainen, H. and others}, title = {{The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions}}, journal = {Molecular neurodegeneration}, year = {2020}, doi = {10.1186/s13024-020-00402-7}, pmid = {32917267}, url = {https://doi.org/10.1186/s13024-020-00402-7} } @article{boschqueralt2021-33619376, author = {Bosch-Queralt, M. and Cantuti-Castelvetri, L. and Damkou, A. and Schifferer, M. and Schlepckow, K. and Alexopoulos, I. and Lütjohann, D. and Klose, C. and others}, title = {{Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination}}, journal = {Nature metabolism}, year = {2021}, doi = {10.1038/s42255-021-00341-7}, pmid = {33619376}, url = {https://doi.org/10.1038/s42255-021-00341-7} } @article{rauchmann2020-31958095, author = {Rauchmann, B. S. and Sadlon, A. and Perneczky, R. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2020}, doi = {10.3233/jad-191120}, pmid = {31958095}, url = {https://doi.org/10.3233/jad-191120} } @article{schoberl2020-31896617, author = {Schöberl, F. and Pradhan, C. and Irving, S. and Buerger, K. and Xiong, G. and Kugler, G. and Kohlbecher, S. and Engmann, J. and others}, title = {{Real-space navigation testing differentiates between amyloid-positive and -negative aMCI}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000008758}, pmid = {31896617}, url = {https://doi.org/10.1212/wnl.0000000000008758} } @article{brendel2016-26912428, author = {Brendel, M. and Probst, F. and Jaworska, A. and Overhoff, F. and Korzhova, V. and Albert, N. L. and Beck, R. and Lindner, S. and others}, title = {{Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study}}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year = {2016}, doi = {10.2967/jnumed.115.167858}, pmid = {26912428}, url = {https://doi.org/10.2967/jnumed.115.167858} } @article{abdelmoity2025-40977577, author = {Abdelmoity, O. and Wisch, J. K. and Kennedy, J. T. and Goyal, M. and Vlassenko, A. and Flores, S. and Handen, B. L. and Head, E. and others}, title = {{Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease}}, journal = {Annals of neurology}, year = {2025}, doi = {10.1002/ana.78002}, pmid = {40977577}, url = {https://doi.org/10.1002/ana.78002} } @article{saftig2015-26522965, author = {Saftig, P. and Lichtenthaler, S. F.}, title = {{The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain}}, journal = {Progress in neurobiology}, year = {2015}, doi = {10.1016/j.pneurobio.2015.10.003}, pmid = {26522965}, url = {https://doi.org/10.1016/j.pneurobio.2015.10.003} } @article{millar2023-38111006, author = {Millar, P. R. and Gordon, B. A. and Wisch, J. K. and Schultz, S. A. and Benzinger, T. L. and Cruchaga, C. and Hassenstab, J. J. and Ibanez, L. and others}, title = {{Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease}}, journal = {Molecular neurodegeneration}, year = {2023}, doi = {10.1186/s13024-023-00688-3}, pmid = {38111006}, url = {https://doi.org/10.1186/s13024-023-00688-3} } @article{lichtenthaler2022-34689040, author = {Lichtenthaler, S. F. and Tschirner, S. K. and Steiner, H.}, title = {{Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2}}, journal = {Current opinion in neurobiology}, year = {2022}, doi = {10.1016/j.conb.2021.09.003}, pmid = {34689040}, url = {https://doi.org/10.1016/j.conb.2021.09.003} } @article{cash2025-40118731, author = {Cash, D. M. and Morgan, K. E. and O'Connor, A. and Veale, T. D. and Malone, I. B. and Poole, T. and Benzinger, T. L. and Gordon, B. A. and others}, title = {{Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100133}, pmid = {40118731}, url = {https://doi.org/10.1016/j.tjpad.2025.100133} } @article{martiskainen2025-40301889, author = {Martiskainen, Henna and Willman, Roosa-Maria and Harju, Päivi and Heikkinen, Sami V. and Heiskanen, Mette and Müller, Stephan A. and Sinisalo, Rosa and Takalo, Mari and others}, title = {{Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease}}, journal = {Molecular Neurodegeneration}, year = {2025}, doi = {10.1186/s13024-025-00830-3}, pmid = {40301889}, url = {https://doi.org/10.1186/s13024-025-00830-3} } @article{bouzigues2025-40673371, author = {Bouzigues, Arabella and Le Du, Vincent and Joulot, Matthieu and Peysson, Ninon and Houot, Marion and Béranger, Benoît and Russell, Lucy Louise and Foster, Phoebe H. and others}, title = {{Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70367}, pmid = {40673371}, url = {https://doi.org/10.1002/alz.70367} } @article{dannert2026-41950304, author = {Dannert, Angelika and Schulz, Nathalie and Klimmt, Julien and Knez, Lea and Groschup, Bernhard and Gonçalves, Carolina Cardoso and Carraro, Caterina and Schifferer, Martina and others}, title = {{A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology}}, journal = {Science Translational Medicine}, year = {2026}, doi = {10.1126/scitranslmed.adu9845}, pmid = {41950304}, url = {https://doi.org/10.1126/scitranslmed.adu9845} } @article{myers2025-40726520, author = {Myers, James A C and Stafford, Tom and Koychev, Ivan G. and Perneczky, Robert and Bandmann, Oliver and Vaci, Nemanja}, title = {{Loneliness, social isolation, and effects on cognitive decline in patients with dementia: A retrospective cohort study using natural language processing}}, journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring}, year = {2025}, doi = {10.1002/dad2.70149}, pmid = {40726520}, url = {https://doi.org/10.1002/dad2.70149} } @article{eckenweber2026-41690259, author = {Eckenweber, Sebastian and Völter, Friederike and Franzmeier, Nicolai and Palleis, Carla and Wagemann, Olivia and Weidinger, Endy and Katzdobler, Sabrina and Wlasich, Elisabeth and others}, title = {{Additive value of early-phase β-Amyloid-PET for the differential diagnosis of non-Alzheimer’s disease dementia}}, journal = {NeuroImage Clinical}, year = {2026}, doi = {10.1016/j.nicl.2026.103963}, pmid = {41690259}, url = {https://doi.org/10.1016/j.nicl.2026.103963} } @article{nubling2026-42609160, author = {Nübling, G. and Marth, L. and Sandkühler, K. and Stockbauer, A. and Wlasich, E. and Jäck, A. and Wagemann, O. and Kustermann, J. and others}, title = {{Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations}}, journal = {Journal of intellectual disability research : JIDR}, year = {2026}, doi = {10.1111/jir.70162}, pmid = {42609160}, url = {https://doi.org/10.1111/jir.70162} } @article{nubling2022-35320851, author = {Nübling, G. and Wagemann, O. and Loosli, S. V. and Wlasich, E. and Danek, A. and Levin, J.}, title = {{[Diagnosing Alzheimer Dementia in People with Down Syndrome in Accordance with ICD, DSM V and A/T/N System]}}, journal = {Fortschritte der Neurologie-Psychiatrie}, year = {2022}, doi = {10.1055/a-1771-6273}, pmid = {35320851}, url = {https://doi.org/10.1055/a-1771-6273} } @article{deming2018-3f7a9435, author = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others}, title = {{The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk}}, journal = {Science translational medicine}, year = {2018}, doi = {10.1101/352179}, url = {https://doi.org/10.1101/352179} } @article{jessen2025-40640062, author = {Jessen, Frank and Arbizu, Javier and Boada, Merçé and Balasa, Mircea and Bennys, Karim and Boban, Marina and Bürger, Katharina and Chincarini, A. and others}, title = {{Comment by European Alzheimer’s Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer’ s disease}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100259}, pmid = {40640062}, url = {https://doi.org/10.1016/j.tjpad.2025.100259} } @article{hornung2025-276be469, author = {Hornung, Simon and Vogl, Dominik P. and Naltsas, Denise and Volta, Beatrice Dalla and Ballmann, Markus and Marcon, Beatrice and Syed, Muhammed Muazzam Kamil and Wu, Yiyang and others}, title = {{Multi‐Targeting Makrozyklische Peptide als Nanomolare Inhibitoren der Selbst‐ und Kreuznukleation der Amyloiden Selbstassemblierung von α‐Synuclein}}, journal = {Angewandte Chemie}, year = {2025}, doi = {10.1002/ange.202422834}, url = {https://doi.org/10.1002/ange.202422834} } @article{bernhardt2025-40713844, author = {Bernhardt, Alexander Maximilian and Roeber, Sigrun and Ruf, Viktoria and Wlasich, Elisabeth and Weidinger, Endy and Longen, Sebastian and Trossbach, Svenja Verena and Gnörich, Johannes S. and others}, title = {{Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology}}, journal = {Acta Neuropathologica Communications}, year = {2025}, doi = {10.1186/s40478-025-02081-1}, pmid = {40713844}, url = {https://doi.org/10.1186/s40478-025-02081-1} } @article{huer2025-39384617, author = {Hüer, T. and Weitzel, M. and Giebel, G. D. and Raszke, P. and Wasem, J. and Levin, J. and Nübling, G. and Wagemann, O. and others}, title = {{[Alzheimer's dementia in people with Down syndrome : Results of guideline-assisted expert interviews on healthcare deficits in the diagnostics and treatment as well as solution approaches]}}, journal = {Zeitschrift fur Gerontologie und Geriatrie}, year = {2025}, doi = {10.1007/s00391-024-02371-8}, pmid = {39384617}, url = {https://doi.org/10.1007/s00391-024-02371-8} } @article{onuroezguer2022-35858613, author = {Onur Oezguer, A. and Claus, Wolff-Menzler and von Arnim Christine A, F. and Frank, Jessen and Fink Gereon, R. and Jens, Wiltfang and Christoph, Laske and Anja, Schneider and others}, title = {{[The Cost of Early Diagnosis of Cognitive Decline in German Memory Clinics]}}, journal = {Fortschritte der Neurologie-Psychiatrie}, year = {2022}, doi = {10.1055/a-1871-9889}, pmid = {35858613}, url = {https://doi.org/10.1055/a-1871-9889} } @article{tato2022-35468638, author = {Tatò, M. and Perneczky, R.}, title = {{[Diagnosing Alzheimer's dementia - a playground for academics or a sensible clinical measure?]}}, journal = {Deutsche medizinische Wochenschrift (1946)}, year = {2022}, doi = {10.1055/a-1769-1376}, pmid = {35468638}, url = {https://doi.org/10.1055/a-1769-1376} } @article{lin2026-2a0fe361, author = {Lin, W. and Beric, A. and Wisch, J. K. and Baker, B. and Jerome, G. and Minton, M. and Preminger, S. and Stauber, J. and others}, title = {{Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer’s Disease}}, journal = {medRxiv}, year = {2026}, doi = {10.64898/2026.03.31.26349851}, url = {https://doi.org/10.64898/2026.03.31.26349851} } @article{kuhn2026-ad82dff0, author = {Kuhn, E. and Antopoulos, G. and Kleineidam, L. and Stark, M. and Roeske, S. and Hoffstaedter, F. and Waite, L. and Peters and others}, title = {{MRI-derived brain aging trajectories across the Alzheimer's continuum: links to cognition, pathology and lifestyle risk factors}}, journal = {medRxiv (preprint)}, year = {2026}, doi = {10.64898/2026.08.19.26360525}, url = {https://doi.org/10.64898/2026.08.19.26360525} } @article{schroeder2026-3ea6500a, author = {Schroeder, J. and Ciora, O.-A. and Heesen, P. and Bendszus, M. and Levin, J. and Perneczky, R. and Bally, L. and Feuerriegel and others}, title = {{Glucagon-like peptide-1 receptor agonist initiation and risk of clinically recorded Alzheimer's disease-type dementia in older adults with type 2 diabetes: a target trial emulation using causal machine learning}}, journal = {medRxiv (preprint)}, year = {2026}, doi = {10.64898/2026.08.21.26361012}, url = {https://doi.org/10.64898/2026.08.21.26361012} }