% alzhub.org library filter % Source: https://alzhub.org/research?institution=I4210105615 % 45 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{jansen2015-25988462, author = {Jansen, W. J. and Ossenkoppele, R. and Knol, D. L. and Tijms, B. M. and Scheltens, P. and Verhey, F. R. and Visser, P. J. and {Amyloid Biomarker Study Group} and others}, title = {{Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis}}, journal = {JAMA}, year = {2015}, doi = {10.1001/jama.2015.4668}, pmid = {25988462}, url = {https://doi.org/10.1001/jama.2015.4668} } @article{vandyck2023-36449413, author = {van Dyck, C. H. and Swanson, C. J. and Aisen, P. and Bateman, R. J. and Chen, C. and Gee, M. and Kanekiyo, M. and Li, D. and others}, title = {{Lecanemab in Early Alzheimer's Disease}}, journal = {The New England journal of medicine}, year = {2023}, doi = {10.1056/nejmoa2212948}, pmid = {36449413}, url = {https://doi.org/10.1056/nejmoa2212948} } @article{atri2018-29318278, author = {Atri, A. and Frölich, L. and Ballard, C. and Tariot, P. N. and Molinuevo, J. L. and Boneva, N. and Windfeld, K. and Raket, L. L. and others}, title = {{Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials}}, journal = {JAMA}, year = {2018}, doi = {10.1001/jama.2017.20373}, pmid = {29318278}, url = {https://doi.org/10.1001/jama.2017.20373} } @article{jansen2022-36066633, author = {Jansen, I. E. and van der Lee, S. J. and Gomez-Fonseca, D. and de Rojas, I. and Dalmasso, M. C. and Grenier-Boley, B. and Zettergren, A. and Mishra, A. and others}, title = {{Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers}}, journal = {Acta neuropathologica}, year = {2022}, doi = {10.1007/s00401-022-02454-z}, pmid = {36066633}, url = {https://doi.org/10.1007/s00401-022-02454-z} } @article{maier2020-32463470, author = {Maier, F. and Spottke, A. and Bach, J. P. and Bartels, C. and Buerger, K. and Dodel, R. and Fellgiebel, A. and Fliessbach, K. and others}, title = {{Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2020}, doi = {10.1001/jamanetworkopen.2020.6027}, pmid = {32463470}, url = {https://doi.org/10.1001/jamanetworkopen.2020.6027} } @article{jansen2022-35099509, author = {Jansen, W. J. and Janssen, O. and Tijms, B. M. and Vos, S. J. B. and Ossenkoppele, R. and Visser, P. J. and {Amyloid Biomarker Study Group} and Aarsland, D. and others}, title = {{Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2021.5216}, pmid = {35099509}, url = {https://doi.org/10.1001/jamaneurol.2021.5216} } @article{leguen2022-35639372, author = {Le Guen, Y. and Belloy, M. E. and Grenier-Boley, B. and de Rojas, I. and Castillo-Morales, A. and Jansen, I. and Nicolas, A. and Bellenguez, C. and others}, title = {{Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.1166}, pmid = {35639372}, url = {https://doi.org/10.1001/jamaneurol.2022.1166} } @article{kleineidam2020-32166339, author = {Kleineidam, L. and Chouraki, V. and Próchnicki, T. and van der Lee, S. J. and Madrid-Márquez, L. and Wagner-Thelen, H. and Karaca, I. and Weinhold, L. and others}, title = {{PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment}}, journal = {Acta neuropathologica}, year = {2020}, doi = {10.1007/s00401-020-02138-6}, pmid = {32166339}, url = {https://doi.org/10.1007/s00401-020-02138-6} } @article{hajek2015-26658776, author = {Hajek, A. and Brettschneider, C. and Lange, C. and Posselt, T. and Wiese, B. and Steinmann, S. and Weyerer, S. and Werle, J. and others}, title = {{Longitudinal Predictors of Institutionalization in Old Age}}, journal = {PloS one}, year = {2015}, doi = {10.1371/journal.pone.0144203}, pmid = {26658776}, url = {https://doi.org/10.1371/journal.pone.0144203} } @article{jessen2014-23375567, author = {Jessen, F. and Wolfsgruber, S. and Wiese, B. and Bickel, H. and Mösch, E. and Kaduszkiewicz, H. and Pentzek, M. and Riedel-Heller, S. G. and others}, title = {{AD dementia risk in late MCI, in early MCI, and in subjective memory impairment}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2014}, doi = {10.1016/j.jalz.2012.09.017}, pmid = {23375567}, url = {https://doi.org/10.1016/j.jalz.2012.09.017} } @article{harold2009-19734902, author = {Harold, Denise H. and Abraham, Richard and Hollingworth, Paul and Sims, Rebecca and Gerrish, Amy and Hamshere, Marian L. and Pahwa, Jaspreet Singh and Moskvina, Valentina and others}, title = {{Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease}}, journal = {Nature Genetics}, year = {2009}, doi = {10.1038/ng.440}, pmid = {19734902}, url = {https://doi.org/10.1038/ng.440} } @article{study2011-21460840, author = {{the Alzheimer's Disease Neuroimaging Initiative} and Hollingworth, Paul and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Lambert, Jean‐Charles and Carrasquillo, Minerva M. and Abraham, Richard and others}, title = {{Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease}}, journal = {Nature Genetics}, year = {2011}, doi = {10.1038/ng.803}, pmid = {21460840}, url = {https://doi.org/10.1038/ng.803} } @article{luppa2010-19934075, author = {Luppa, M. and Luck, T. and Weyerer, S. and König, H. H. and Brähler, E. and Riedel-Heller, S. G.}, title = {{Prediction of institutionalization in the elderly. A systematic review}}, journal = {Age and ageing}, year = {2010}, doi = {10.1093/ageing/afp202}, pmid = {19934075}, url = {https://doi.org/10.1093/ageing/afp202} } @article{haenisch2015-25341874, author = {Haenisch, B. and von Holt, K. and Wiese, B. and Prokein, J. and Lange, C. and Ernst, A. and Brettschneider, C. and König, H. H. and others}, title = {{Risk of dementia in elderly patients with the use of proton pump inhibitors}}, journal = {European archives of psychiatry and clinical neuroscience}, year = {2015}, doi = {10.1007/s00406-014-0554-0}, pmid = {25341874}, url = {https://doi.org/10.1007/s00406-014-0554-0} } @article{vos2015-25693589, author = {Vos, S. J. and Verhey, F. and Frölich, L. and Kornhuber, J. and Wiltfang, J. and Maier, W. and Peters, O. and Rüther, E. and others}, title = {{Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage}}, journal = {Brain : a journal of neurology}, year = {2015}, doi = {10.1093/brain/awv029}, pmid = {25693589}, url = {https://doi.org/10.1093/brain/awv029} } @article{kurz2012-21986341, author = {Kurz, A. and Thöne-Otto, A. and Cramer, B. and Egert, S. and Frölich, L. and Gertz, H. J. and Kehl, V. and Wagenpfeil, S. and others}, title = {{CORDIAL: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: a multicenter, randomized, controlled trial}}, journal = {Alzheimer disease and associated disorders}, year = {2012}, doi = {10.1097/wad.0b013e318231e46e}, pmid = {21986341}, url = {https://doi.org/10.1097/wad.0b013e318231e46e} } @article{jansen2018-29188296, author = {Jansen, W. J. and Ossenkoppele, R. and Tijms, B. M. and Fagan, A. M. and Hansson, O. and Klunk, W. E. and van der Flier, W. M. and Villemagne, V. L. and others}, title = {{Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia}}, journal = {JAMA psychiatry}, year = {2018}, doi = {10.1001/jamapsychiatry.2017.3391}, pmid = {29188296}, url = {https://doi.org/10.1001/jamapsychiatry.2017.3391} } @article{nicolas2025-40533518, author = {Nicolas, A. and Sherva, R. and Grenier-Boley, B. and Kim, Y. and Kikuchi, M. and Timsina, J. and de Rojas, I. and Dalmasso, M. C. and Zhou, X. and Le Guen, Y. and Arboleda-Bustos, C. E. and Camargos Bicalho, M. A. and others}, title = {{Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations}}, journal = {Nature genetics}, year = {2025}, doi = {10.1038/s41588-025-02227-w}, pmid = {40533518}, url = {https://doi.org/10.1038/s41588-025-02227-w} } @article{dubois2024-39483064, author = {Dubois, B. and Villain, N. and Schneider, L. and Fox, N. and Campbell, N. and Galasko, D. and Kivipelto, M. and Jessen, F. and others}, title = {{Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.3770}, pmid = {39483064}, url = {https://doi.org/10.1001/jamaneurol.2024.3770} } @article{morgan2019-31047856, author = {Morgan, A. R. and Touchard, S. and Leckey, C. and O'Hagan, C. and Nevado-Holgado, A. J. and {NIMA Consortium} and Barkhof, F. and Bertram, L. and others}, title = {{Inflammatory biomarkers in Alzheimer's disease plasma}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.03.007}, pmid = {31047856}, url = {https://doi.org/10.1016/j.jalz.2019.03.007} } @article{wischik2026-41570392, author = {Wischik, C. M. and Stefanacci, R. and Bentham, P. and Gauthier, S. and Zetterberg, H. and Wilcock, G. K. and Froelich, L. and Burns, A. and MacSweeney, E. and Ballard, C. and others}, title = {{Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease}}, journal = {The Journal of Prevention of Alzheimer's Disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100480}, pmid = {41570392}, url = {https://doi.org/10.1016/j.tjpad.2026.100480} } @article{gustavsson2023-35652476, author = {Gustavsson, A. and Norton, N. and Fast, T. and Frölich, L. and Georges, J. and Holzapfel, D. and Kirabali, T. and Krolak-Salmon, P. and others}, title = {{Global estimates on the number of persons across the Alzheimer's disease continuum}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.12694}, pmid = {35652476}, url = {https://doi.org/10.1002/alz.12694} } @article{vanmaurik2019-31526625, author = {van Maurik, I. S. and Vos, S. J. and Bos, I. and Bouwman, F. H. and Teunissen, C. E. and Scheltens, P. and Barkhof, F. and Frolich, L. and others}, title = {{Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study}}, journal = {The Lancet. Neurology}, year = {2019}, doi = {10.1016/s1474-4422(19)30283-2}, pmid = {31526625}, url = {https://doi.org/10.1016/s1474-4422(19)30283-2} } @article{luo2023-37195665, author = {Luo, J. and Thomassen, J. Q. and Bellenguez, C. and Grenier-Boley, B. and de Rojas, I. and Castillo, A. and Parveen, K. and others}, title = {{Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.13734}, pmid = {37195665}, url = {https://doi.org/10.1001/jamanetworkopen.2023.13734} } @article{stamate2019-31890857, author = {Stamate, D. and Kim, M. and Proitsi, P. and Westwood, S. and Baird, A. and Nevado-Holgado, A. and Hye, A. and Bos, I. and others}, title = {{A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2019}, doi = {10.1016/j.trci.2019.11.001}, pmid = {31890857}, url = {https://doi.org/10.1016/j.trci.2019.11.001} } @article{jones2010-21085570, author = {Jones, L. and Holmans, P. A. and Hamshere, M. L. and Harold, D. and Moskvina, V. and Ivanov, D. and Pocklington, A. and Abraham, R. and others}, title = {{Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease}}, journal = {PloS one}, year = {2010}, doi = {10.1371/journal.pone.0013950}, pmid = {21085570}, url = {https://doi.org/10.1371/journal.pone.0013950} } @article{braun2015-26324898, author = {Braun, U. and Schäfer, A. and Walter, H. and Erk, S. and Romanczuk-Seiferth, N. and Haddad, L. and Schweiger, J. I. and Grimm, O. and others}, title = {{Dynamic reconfiguration of frontal brain networks during executive cognition in humans}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2015}, doi = {10.1073/pnas.1422487112}, pmid = {26324898}, url = {https://doi.org/10.1073/pnas.1422487112} } @article{ahmad2024-39080778, author = {Ahmad, S. and Yang, W. and Orellana, A. and Frölich, L. and de Rojas, I. and Cano, A. and Boada, M. and Hernández, I. and others}, title = {{Association of oxidative stress and inflammatory metabolites with Alzheimer's disease cerebrospinal fluid biomarkers in mild cognitive impairment}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01542-4}, pmid = {39080778}, url = {https://doi.org/10.1186/s13195-024-01542-4} } @article{thomassen2026-42736378, author = {Thomassen, J. Q. and Leonard, H. and Ulms, B. and Grenier-Boley, B. and Heikkinen, S. and Garcia-González, P. and Castillo-Morales, A. and Kikuchi, M. and Gim, J. and Cao, H. and Küçükali, F. and Amin, N. and others}, title = {{APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease}}, journal = {Nature genetics}, year = {2026}, doi = {10.1038/s41588-026-02713-9}, pmid = {42736378}, url = {https://doi.org/10.1038/s41588-026-02713-9} } @article{luck2007-17848793, author = {Luck, T. and Riedel-Heller, S. G. and Kaduszkiewicz, H. and Bickel, H. and Jessen, F. and Pentzek, M. and Wiese, B. and Koelsch, H. and others}, title = {{Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)}}, journal = {Dementia and geriatric cognitive disorders}, year = {2007}, doi = {10.1159/000108099}, pmid = {17848793}, url = {https://doi.org/10.1159/000108099} } @article{tomita1997-9050898, author = {Tomita, T. and Maruyama, K. and Saido, T. C. and Kume, H. and Shinozaki, K. and Tokuhiro, S. and Capell, A. and Walter, J. and others}, title = {{The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1997}, doi = {10.1073/pnas.94.5.2025}, pmid = {9050898}, url = {https://doi.org/10.1073/pnas.94.5.2025} } @article{weyer2011-21522131, author = {Weyer, S. W. and Klevanski, M. and Delekate, A. and Voikar, V. and Aydin, D. and Hick, M. and Filippov, M. and Drost, N. and others}, title = {{APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP}}, journal = {The EMBO journal}, year = {2011}, doi = {10.1038/emboj.2011.119}, pmid = {21522131}, url = {https://doi.org/10.1038/emboj.2011.119} } @article{fischer2025-40933821, author = {Fischer, Florian U. and Kollmann, Bianca and Wolf, Dominik Georg Friedrich and Sebastian, Alexandra and Knaepen, Kristel and Riedel, David and Mierau, Andreas and Ruffini, Nicolas and others}, title = {{Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study}}, journal = {Frontiers in Aging Neuroscience}, year = {2025}, doi = {10.3389/fnagi.2025.1587395}, pmid = {40933821}, url = {https://doi.org/10.3389/fnagi.2025.1587395} } @article{popp2015-25435336, author = {Popp, J. and Wolfsgruber, S. and Heuser, I. and Peters, O. and Hüll, M. and Schröder, J. and Möller, H. J. and Lewczuk, P. and others}, title = {{Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type}}, journal = {Neurobiology of aging}, year = {2015}, doi = {10.1016/j.neurobiolaging.2014.10.031}, pmid = {25435336}, url = {https://doi.org/10.1016/j.neurobiolaging.2014.10.031} } @article{hampel2011-22137045, author = {Hampel, H. and Prvulovic, D. and Teipel, S. and Jessen, F. and Luckhaus, C. and Frölich, L. and Riepe, M. W. and Dodel, R. and others}, title = {{The future of Alzheimer's disease: the next 10 years}}, journal = {Progress in neurobiology}, year = {2011}, doi = {10.1016/j.pneurobio.2011.11.008}, pmid = {22137045}, url = {https://doi.org/10.1016/j.pneurobio.2011.11.008} } @article{handels2025-39800459, author = {Handels, Ron L. H. and Hataiyusuk, Somboon and Wimo, Anders and Sköldunger, Anders and Bakker, Christian and Bieber, Anja and Ciccone, Alfonso and Defanti, Carlo Alberto and others}, title = {{Informal care for people with dementia in Europe}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2024.100015}, pmid = {39800459}, url = {https://doi.org/10.1016/j.tjpad.2024.100015} } @article{reinhardt2018-29358714, author = {Reinhardt, S. and Stoye, N. and Luderer, M. and Kiefer, F. and Schmitt, U. and Lieb, K. and Endres, K.}, title = {{Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks}}, journal = {Scientific reports}, year = {2018}, doi = {10.1038/s41598-018-19577-7}, pmid = {29358714}, url = {https://doi.org/10.1038/s41598-018-19577-7} } @article{vollhardt2025-39999928, author = {Vollhardt, Alisa and Frölich, Lutz and Stockbauer, Anna and Danek, Adrian and Schmitz, Christoph and Wahl, Anna-Sophia}, title = {{Towards a better diagnosis and treatment of dementia: Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia}}, journal = {Neurobiology of Disease}, year = {2025}, doi = {10.1016/j.nbd.2025.106845}, pmid = {39999928}, url = {https://doi.org/10.1016/j.nbd.2025.106845} } @article{gattaz1995-7893853, author = {Gattaz, W. F. and Maras, A. and Cairns, N. J. and Levy, R. and Förstl, H.}, title = {{Decreased phospholipase A2 activity in Alzheimer brains}}, journal = {Biological psychiatry}, year = {1995}, doi = {10.1016/0006-3223(94)00123-k}, pmid = {7893853}, url = {https://doi.org/10.1016/0006-3223(94)00123-k} } @article{grimm2008-18308724, author = {Grimm, M. O. and Grimm, H. S. and Tomic, I. and Beyreuther, K. and Hartmann, T. and Bergmann, C.}, title = {{Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels}}, journal = {The Journal of biological chemistry}, year = {2008}, doi = {10.1074/jbc.m801520200}, pmid = {18308724}, url = {https://doi.org/10.1074/jbc.m801520200} } @article{dyrba2015-25644739, author = {Dyrba, M. and Barkhof, F. and Fellgiebel, A. and Filippi, M. and Hausner, L. and Hauenstein, K. and Kirste, T. and Teipel, S. J. and others}, title = {{Predicting Prodromal Alzheimer's Disease in Subjects with Mild Cognitive Impairment Using Machine Learning Classification of Multimodal Multicenter Diffusion-Tensor and Magnetic Resonance Imaging Data}}, journal = {Journal of neuroimaging : official journal of the American Society of Neuroimaging}, year = {2015}, doi = {10.1111/jon.12214}, pmid = {25644739}, url = {https://doi.org/10.1111/jon.12214} } @article{frederiksen2025-40413561, author = {Frederiksen, Kristian Steen and Boada, Merçé and Dubois, Bruno and Engelborghs, Sebastiaan and Frisoni, Giovanni Battista and Georges, Jean and Hort, Jakub and Jönsson, Linus and others}, title = {{Navigating the introduction of anti-amyloid therapy in Europe: a position statement by individual members of the EADC}}, journal = {Alzheimer s Research \& Therapy}, year = {2025}, doi = {10.1186/s13195-025-01766-y}, pmid = {40413561}, url = {https://doi.org/10.1186/s13195-025-01766-y} } @article{heller2025-41051875, author = {Heller, Nathan H. and Barrett, Frederick Streeter and Buchborn, Tobias and Collerton, Daniel and Dupuis, David and Halberstadt, Adam L. and Jardri, Renaud and Noorani, Tehseen N. and others}, title = {{Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases}}, journal = {Schizophrenia Bulletin}, year = {2025}, doi = {10.1093/schbul/sbaf068}, pmid = {41051875}, url = {https://doi.org/10.1093/schbul/sbaf068} } @article{jessen2025-40640062, author = {Jessen, Frank and Arbizu, Javier and Boada, Merçé and Balasa, Mircea and Bennys, Karim and Boban, Marina and Bürger, Katharina and Chincarini, A. and others}, title = {{Comment by European Alzheimer’s Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer’ s disease}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100259}, pmid = {40640062}, url = {https://doi.org/10.1016/j.tjpad.2025.100259} } @article{onuroezguer2022-35858613, author = {Onur Oezguer, A. and Claus, Wolff-Menzler and von Arnim Christine A, F. and Frank, Jessen and Fink Gereon, R. and Jens, Wiltfang and Christoph, Laske and Anja, Schneider and others}, title = {{[The Cost of Early Diagnosis of Cognitive Decline in German Memory Clinics]}}, journal = {Fortschritte der Neurologie-Psychiatrie}, year = {2022}, doi = {10.1055/a-1871-9889}, pmid = {35858613}, url = {https://doi.org/10.1055/a-1871-9889} }