% alzhub.org library filter % Source: https://alzhub.org/research?institution=I2801952686 % 275 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{kunkle2019-30820047, author = {Kunkle, B. W. and Grenier-Boley, B. and Sims, R. and Bis, J. C. and Damotte, V. and Naj, A. C. and Boland, A. and Vronskaya, M. and others}, title = {{Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing}}, journal = {Nature genetics}, year = {2019}, doi = {10.1038/s41588-019-0358-2}, pmid = {30820047}, url = {https://doi.org/10.1038/s41588-019-0358-2} } @article{wolters2020-32611641, author = {Wolters, F. J. and Chibnik, L. B. and Waziry, R. and Anderson, R. and Berr, C. and Beiser, A. and Bis, J. C. and Blacker, D. and others}, title = {{Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000010022}, pmid = {32611641}, url = {https://doi.org/10.1212/wnl.0000000000010022} } @article{sims2017-28714976, author = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others}, title = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}}, journal = {Nature genetics}, year = {2017}, doi = {10.1038/ng.3916}, pmid = {28714976}, url = {https://doi.org/10.1038/ng.3916} } @article{jun2016-25778476, author = {Jun, G. and Ibrahim-Verbaas, C. A. and Vronskaya, M. and Lambert, J. C. and Chung, J. and Naj, A. C. and Kunkle, B. W. and Wang, L. S. and others}, title = {{A novel Alzheimer disease locus located near the gene encoding tau protein}}, journal = {Molecular psychiatry}, year = {2016}, doi = {10.1038/mp.2015.23}, pmid = {25778476}, url = {https://doi.org/10.1038/mp.2015.23} } @article{hendriks2021-34279544, author = {Hendriks, S. and Peetoom, K. and Bakker, C. and van der Flier, W. M. and Papma, J. M. and Koopmans, R. and Verhey, F. R. J. and de Vugt, M. and others}, title = {{Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis}}, journal = {JAMA neurology}, year = {2021}, doi = {10.1001/jamaneurol.2021.2161}, pmid = {34279544}, url = {https://doi.org/10.1001/jamaneurol.2021.2161} } @article{bergeron2018-30255971, author = {Bergeron, D. and Gorno-Tempini, M. L. and Rabinovici, G. D. and Santos-Santos, M. A. and Seeley, W. and Miller, B. L. and Pijnenburg, Y. and Keulen, M. A. and others}, title = {{Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia}}, journal = {Annals of neurology}, year = {2018}, doi = {10.1002/ana.25333}, pmid = {30255971}, url = {https://doi.org/10.1002/ana.25333} } @article{hilal2018-30068634, author = {Hilal, S. and Tan, C. S. and Adams, H. H. H. and Habes, M. and Mok, V. and Venketasubramanian, N. and Hofer, E. and Ikram, M. K. and others}, title = {{Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006079}, pmid = {30068634}, url = {https://doi.org/10.1212/wnl.0000000000006079} } @article{fornage2011-21681796, author = {Fornage, M. and Debette, S. and Bis, J. C. and Schmidt, H. and Ikram, M. A. and Dufouil, C. and Sigurdsson, S. and Lumley, T. and others}, title = {{Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22403}, pmid = {21681796}, url = {https://doi.org/10.1002/ana.22403} } @article{pottier2025-40280976, author = {Pottier, Cyril P. and Küçükali, Fahri and Baker, Matt C. and Batzler, Anthony and Jenkins, Gregory D. and van Blitterswijk, Marka and Vicente, Cristina T. and De Coster, Wouter and others}, title = {{Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing}}, journal = {Nature Communications}, year = {2025}, doi = {10.1038/s41467-025-59216-0}, pmid = {40280976}, url = {https://doi.org/10.1038/s41467-025-59216-0} } @article{ding2020-31706889, author = {Ding, J. and Davis-Plourde, K. L. and Sedaghat, S. and Tully, P. J. and Wang, W. and Phillips, C. and Pase, M. P. and Himali, J. J. and others}, title = {{Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies}}, journal = {The Lancet. Neurology}, year = {2020}, doi = {10.1016/s1474-4422(19)30393-x}, pmid = {31706889}, url = {https://doi.org/10.1016/s1474-4422(19)30393-x} } @article{intveld2001-11794217, author = {in t' Veld, B. A. and Ruitenberg, A. and Hofman, A. and Launer, L. J. and van Duijn, C. M. and Stijnen, T. and Breteler, M. M. and Stricker, B. H.}, title = {{Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2001}, doi = {10.1056/nejmoa010178}, pmid = {11794217}, url = {https://doi.org/10.1056/nejmoa010178} } @article{jonsson2013-23150908, author = {Jonsson, T. and Stefansson, H. and Steinberg, S. and Jonsdottir, I. and Jonsson, P. V. and Snaedal, J. and Bjornsson, S. and Huttenlocher, J. and others}, title = {{Variant of TREM2 associated with the risk of Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2013}, doi = {10.1056/nejmoa1211103}, pmid = {23150908}, url = {https://doi.org/10.1056/nejmoa1211103} } @article{rojas2021-33827960, author = {Rojas, J. C. and Wang, P. and Staffaroni, A. M. and Heller, C. and Cobigo, Y. and Wolf, A. and Goh, S. M. and Ljubenkov, P. A. and others}, title = {{Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011848}, pmid = {33827960}, url = {https://doi.org/10.1212/wnl.0000000000011848} } @article{bruck2025-39778977, author = {Brück, C. C. and Mooldijk, S. S. and Kuiper, L. M. and Sambou, M. L. and Licher, S. and Mattace-Raso, F. and Wolters, F. J.}, title = {{Time to nursing home admission and death in people with dementia: systematic review and meta-analysis}}, journal = {BMJ}, year = {2025}, doi = {10.1136/bmj-2024-080636}, pmid = {39778977}, url = {https://doi.org/10.1136/bmj-2024-080636} } @article{jansen2022-36066633, author = {Jansen, I. E. and van der Lee, S. J. and Gomez-Fonseca, D. and de Rojas, I. and Dalmasso, M. C. and Grenier-Boley, B. and Zettergren, A. and Mishra, A. and others}, title = {{Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers}}, journal = {Acta neuropathologica}, year = {2022}, doi = {10.1007/s00401-022-02454-z}, pmid = {36066633}, url = {https://doi.org/10.1007/s00401-022-02454-z} } @article{li2026-41559019, author = {Li, Joanne M. and Gauen, Abigail and Zmora, Rachel and Stephen, John J. and Petito, Lucia C. and Scholtens, Denise and Peterson, Elizabeth and Kohli-Lynch, Ciaran Navin and others}, title = {{Midlife and late‐life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project}}, journal = {Alzheimer s \& Dementia}, year = {2026}, doi = {10.1002/alz.71065}, pmid = {41559019}, url = {https://doi.org/10.1002/alz.71065} } @article{albanese2017-28761927, author = {Albanese, E. and Launer, L. J. and Egger, M. and Prince, M. J. and Giannakopoulos, P. and Wolters, F. J. and Egan, K.}, title = {{Body mass index in midlife and dementia: Systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2017}, doi = {10.1016/j.dadm.2017.05.007}, pmid = {28761927}, url = {https://doi.org/10.1016/j.dadm.2017.05.007} } @article{therriault2023-36508198, author = {Therriault, J. and Vermeiren, M. and Servaes, S. and Tissot, C. and Ashton, N. J. and Benedet, A. L. and Karikari, T. K. and Lantero-Rodriguez, J. and others}, title = {{Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2022.4485}, pmid = {36508198}, url = {https://doi.org/10.1001/jamaneurol.2022.4485} } @article{ashton2021-34099648, author = {Ashton, N. J. and Janelidze, S. and Al Khleifat, A. and Leuzy, A. and van der Ende, E. L. and Karikari, T. K. and Benedet, A. L. and Pascoal, T. A. and others}, title = {{A multicentre validation study of the diagnostic value of plasma neurofilament light}}, journal = {Nature communications}, year = {2021}, doi = {10.1038/s41467-021-23620-z}, pmid = {34099648}, url = {https://doi.org/10.1038/s41467-021-23620-z} } @article{armstrong2020-32517579, author = {Armstrong, N. J. and Mather, K. A. and Sargurupremraj, M. and Knol, M. J. and Malik, R. and Satizabal, C. L. and Yanek, L. R. and Wen, W. and others}, title = {{Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities}}, journal = {Stroke}, year = {2020}, doi = {10.1161/strokeaha.119.027544}, pmid = {32517579}, url = {https://doi.org/10.1161/strokeaha.119.027544} } @article{wolters2019-31356640, author = {Wolters, F. J. and Yang, Q. and Biggs, M. L. and Jakobsdottir, J. and Li, S. and Evans, D. S. and Bis, J. C. and Harris, T. B. and others}, title = {{The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)}}, journal = {PloS one}, year = {2019}, doi = {10.1371/journal.pone.0219668}, pmid = {31356640}, url = {https://doi.org/10.1371/journal.pone.0219668} } @article{sargurupremraj2020-33293549, author = {Sargurupremraj, M. and Suzuki, H. and Jian, X. and Sarnowski, C. and Evans, T. E. and Bis, J. C. and Eiriksdottir, G. and Sakaue, S. and others}, title = {{Cerebral small vessel disease genomics and its implications across the lifespan}}, journal = {Nature communications}, year = {2020}, doi = {10.1038/s41467-020-19111-2}, pmid = {33293549}, url = {https://doi.org/10.1038/s41467-020-19111-2} } @article{buergel2022-36138150, author = {Buergel, T. and Steinfeldt, J. and Ruyoga, G. and Pietzner, M. and Bizzarri, D. and Vojinovic, D. and Upmeier Zu Belzen, J. and Loock, L. and others}, title = {{Metabolomic profiles predict individual multidisease outcomes}}, journal = {Nature medicine}, year = {2022}, doi = {10.1038/s41591-022-01980-3}, pmid = {36138150}, url = {https://doi.org/10.1038/s41591-022-01980-3} } @article{engelhart2002-12076218, author = {Engelhart, M. J. and Geerlings, M. I. and Ruitenberg, A. and van Swieten, J. C. and Hofman, A. and Witteman, J. C. and Breteler, M. M.}, title = {{Dietary intake of antioxidants and risk of Alzheimer disease}}, journal = {JAMA}, year = {2002}, doi = {10.1001/jama.287.24.3223}, pmid = {12076218}, url = {https://doi.org/10.1001/jama.287.24.3223} } @article{vanderlee2018-29555425, author = {van der Lee, S. J. and Wolters, F. J. and Ikram, M. K. and Hofman, A. and Ikram, M. A. and Amin, N. and van Duijn, C. M.}, title = {{The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(18)30053-x}, pmid = {29555425}, url = {https://doi.org/10.1016/s1474-4422(18)30053-x} } @article{bridel2019-31206160, author = {Bridel, C. and van Wieringen, W. N. and Zetterberg, H. and Tijms, B. M. and Teunissen, C. E. and {the NFL Group} and Alvarez-Cermeño, J. C. and Andreasson, U. and others}, title = {{Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2019.1534}, pmid = {31206160}, url = {https://doi.org/10.1001/jamaneurol.2019.1534} } @article{slooter1998-9678314, author = {Slooter, A. J. and Cruts, M. and Kalmijn, S. and Hofman, A. and Breteler, M. M. and Van Broeckhoven, C. and van Duijn, C. M.}, title = {{Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study}}, journal = {Archives of neurology}, year = {1998}, doi = {10.1001/archneur.55.7.964}, pmid = {9678314}, url = {https://doi.org/10.1001/archneur.55.7.964} } @article{verhaaren2015-25663218, author = {Verhaaren, B. F. and Debette, S. and Bis, J. C. and Smith, J. A. and Ikram, M. K. and Adams, H. H. and Beecham, A. H. and Rajan, K. B. and others}, title = {{Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI}}, journal = {Circulation. Cardiovascular genetics}, year = {2015}, doi = {10.1161/circgenetics.114.000858}, pmid = {25663218}, url = {https://doi.org/10.1161/circgenetics.114.000858} } @article{chauhan2015-25670335, author = {Chauhan, G. and Adams, H. H. H. and Bis, J. C. and Weinstein, G. and Yu, L. and Töglhofer, A. M. and Smith, A. V. and van der Lee, S. J. and others}, title = {{Association of Alzheimer's disease GWAS loci with MRI markers of brain aging}}, journal = {Neurobiology of aging}, year = {2015}, doi = {10.1016/j.neurobiolaging.2014.12.028}, pmid = {25670335}, url = {https://doi.org/10.1016/j.neurobiolaging.2014.12.028} } @article{schrijvers2012-22551732, author = {Schrijvers, E. M. and Verhaaren, B. F. and Koudstaal, P. J. and Hofman, A. and Ikram, M. A. and Breteler, M. M.}, title = {{Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182553be6}, pmid = {22551732}, url = {https://doi.org/10.1212/wnl.0b013e3182553be6} } @article{nho2019-31365104, author = {Nho, K. and Kueider-Paisley, A. and Ahmad, S. and MahmoudianDehkordi, S. and Arnold, M. and Risacher, S. L. and Louie, G. and Blach, C. and others}, title = {{Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.7978}, pmid = {31365104}, url = {https://doi.org/10.1001/jamanetworkopen.2019.7978} } @article{eikelboom2021-34413181, author = {Eikelboom, W. S. and van den Berg, E. and Singleton, E. H. and Baart, S. J. and Coesmans, M. and Leeuwis, A. E. and Teunissen, C. E. and van Berckel, B. N. M. and others}, title = {{Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum: Cross-sectional and Longitudinal Associations}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012598}, pmid = {34413181}, url = {https://doi.org/10.1212/wnl.0000000000012598} } @article{lithell2003-12714861, author = {Lithell, H. and Hansson, L. and Skoog, I. and Elmfeldt, D. and Hofman, A. and Olofsson, B. and Trenkwalder, P. and Zanchetti, A. and others}, title = {{The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial}}, journal = {Journal of hypertension}, year = {2003}, doi = {10.1097/00004872-200305000-00011}, pmid = {12714861}, url = {https://doi.org/10.1097/00004872-200305000-00011} } @article{dewolf2020-32206776, author = {de Wolf, F. and Ghanbari, M. and Licher, S. and McRae-McKee, K. and Gras, L. and Weverling, G. J. and Wermeling, P. and Sedaghat, S. and others}, title = {{Plasma tau, neurofilament light chain and amyloid-β levels and risk of dementia; a population-based cohort study}}, journal = {Brain : a journal of neurology}, year = {2020}, doi = {10.1093/brain/awaa054}, pmid = {32206776}, url = {https://doi.org/10.1093/brain/awaa054} } @article{holstege2022-36411364, author = {Holstege, H. and Hulsman, M. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Grozeva, D. and van Rooij, J. G. J. and Sims, R. and others}, title = {{Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease}}, journal = {Nature genetics}, year = {2022}, doi = {10.1038/s41588-022-01208-7}, pmid = {36411364}, url = {https://doi.org/10.1038/s41588-022-01208-7} } @article{rojassaunero2023-37139580, author = {Rojas-Saunero, L. P. and Young, J. G. and Didelez, V. and Ikram, M. A. and Swanson, S. A.}, title = {{Considering Questions Before Methods in Dementia Research With Competing Events and Causal Goals}}, journal = {American journal of epidemiology}, year = {2023}, doi = {10.1093/aje/kwad090}, pmid = {37139580}, url = {https://doi.org/10.1093/aje/kwad090} } @article{nguyenho2024-38913396, author = {Nguyen Ho, P. T. and Hoepel, S. J. W. and Rodriguez-Ayllon, M. and Luik, A. I. and Vernooij, M. W. and Neitzel, J.}, title = {{Sleep, 24-Hour Activity Rhythms, and Subsequent Amyloid-β Pathology}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.1755}, pmid = {38913396}, url = {https://doi.org/10.1001/jamaneurol.2024.1755} } @article{leguen2022-35639372, author = {Le Guen, Y. and Belloy, M. E. and Grenier-Boley, B. and de Rojas, I. and Castillo-Morales, A. and Jansen, I. and Nicolas, A. and Bellenguez, C. and others}, title = {{Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.1166}, pmid = {35639372}, url = {https://doi.org/10.1001/jamaneurol.2022.1166} } @article{majounie2012-22406228, author = {Majounie, E. and Renton, A. E. and Mok, K. and Dopper, E. G. and Waite, A. and Rollinson, S. and Chiò, A. and Restagno, G. and others}, title = {{Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2012}, doi = {10.1016/s1474-4422(12)70043-1}, pmid = {22406228}, url = {https://doi.org/10.1016/s1474-4422(12)70043-1} } @article{vanoijen2006-16857570, author = {van Oijen, M. and Hofman, A. and Soares, H. D. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study}}, journal = {The Lancet. Neurology}, year = {2006}, doi = {10.1016/s1474-4422(06)70501-4}, pmid = {16857570}, url = {https://doi.org/10.1016/s1474-4422(06)70501-4} } @article{ott1998-9652667, author = {Ott, A. and Slooter, A. J. and Hofman, A. and van Harskamp, F. and Witteman, J. C. and Van Broeckhoven, C. and van Duijn, C. M. and Breteler, M. M.}, title = {{Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study}}, journal = {Lancet (London, England)}, year = {1998}, doi = {10.1016/s0140-6736(97)07541-7}, pmid = {9652667}, url = {https://doi.org/10.1016/s0140-6736(97)07541-7} } @article{young2018-30323170, author = {Young, A. L. and Marinescu, R. V. and Oxtoby, N. P. and Bocchetta, M. and Yong, K. and Firth, N. C. and Cash, D. M. and Thomas, D. L. and others}, title = {{Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference}}, journal = {Nature communications}, year = {2018}, doi = {10.1038/s41467-018-05892-0}, pmid = {30323170}, url = {https://doi.org/10.1038/s41467-018-05892-0} } @article{wolters2017-28588075, author = {Wolters, F. J. and Zonneveld, H. I. and Hofman, A. and van der Lugt, A. and Koudstaal, P. J. and Vernooij, M. W. and Ikram, M. A. and {Heart-Brain Connection Collaborative Research Group}}, title = {{Cerebral Perfusion and the Risk of Dementia: A Population-Based Study}}, journal = {Circulation}, year = {2017}, doi = {10.1161/circulationaha.117.027448}, pmid = {28588075}, url = {https://doi.org/10.1161/circulationaha.117.027448} } @article{reitz2007-17785668, author = {Reitz, C. and den Heijer, T. and van Duijn, C. and Hofman, A. and Breteler, M. M.}, title = {{Relation between smoking and risk of dementia and Alzheimer disease: the Rotterdam Study}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000271395.29695.9a}, pmid = {17785668}, url = {https://doi.org/10.1212/01.wnl.0000271395.29695.9a} } @article{licher2018-29740780, author = {Licher, S. and Yilmaz, P. and Leening, M. J. G. and Wolters, F. J. and Vernooij, M. W. and Stephan, B. C. M. and Ikram, M. K. and Ikram, M. A.}, title = {{External validation of four dementia prediction models for use in the general community-dwelling population: a comparative analysis from the Rotterdam Study}}, journal = {European journal of epidemiology}, year = {2018}, doi = {10.1007/s10654-018-0403-y}, pmid = {29740780}, url = {https://doi.org/10.1007/s10654-018-0403-y} } @article{xiao2022-35618435, author = {Xiao, T. and van Kleef, L. A. and Ikram, M. K. and de Knegt, R. J. and Ikram, M. A.}, title = {{Association of Nonalcoholic Fatty Liver Disease and Fibrosis With Incident Dementia and Cognition: The Rotterdam Study}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200770}, pmid = {35618435}, url = {https://doi.org/10.1212/wnl.0000000000200770} } @article{xiao2023-36948596, author = {Xiao, T. and Ghatan, S. and Mooldijk, S. S. and Trajanoska, K. and Oei, L. and Gomez, M. M. and Ikram, M. K. and Rivadeneira, F. and others}, title = {{Association of Bone Mineral Density and Dementia: The Rotterdam Study}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207220}, pmid = {36948596}, url = {https://doi.org/10.1212/wnl.0000000000207220} } @article{vermeer2003-12660385, author = {Vermeer, Sarah E. and Prins, Niels D. and den Heijer, Tom and Hofman, Albert and Koudstaal, Peter J. and Breteler, Monique M.B.}, title = {{Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline}}, journal = {New England Journal of Medicine}, year = {2003}, doi = {10.1056/nejmoa022066}, pmid = {12660385}, url = {https://doi.org/10.1056/nejmoa022066} } @article{vandeerlin2010-20154673, author = {Van Deerlin, V. M. and Sleiman, P. M. and Martinez-Lage, M. and Chen-Plotkin, A. and Wang, L. S. and Graff-Radford, N. R. and Dickson, D. W. and Rademakers, R. and others}, title = {{Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions}}, journal = {Nature genetics}, year = {2010}, doi = {10.1038/ng.536}, pmid = {20154673}, url = {https://doi.org/10.1038/ng.536} } @article{bellenguez2022-35379992, author = {Bellenguez, C. and Küçükali, F. and Jansen, I. E. and Kleineidam, L. and Moreno-Grau, S. and Amin, N. and Naj, A. C. and Campos-Martin, R. and others}, title = {{New insights into the genetic etiology of Alzheimer's disease and related dementias}}, journal = {Nature genetics}, year = {2022}, doi = {10.1038/s41588-022-01024-z}, pmid = {35379992}, url = {https://doi.org/10.1038/s41588-022-01024-z} } @article{mutlu2018-29946702, author = {Mutlu, U. and Colijn, J. M. and Ikram, M. A. and Bonnemaijer, P. W. M. and Licher, S. and Wolters, F. J. and Tiemeier, H. and Koudstaal, P. J. and others}, title = {{Association of Retinal Neurodegeneration on Optical Coherence Tomography With Dementia: A Population-Based Study}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2018.1563}, pmid = {29946702}, url = {https://doi.org/10.1001/jamaneurol.2018.1563} } @article{lambert2013-24162737, author = {Lambert, Jean‐Charles and Ibrahim‐Verbaas, Carla A. and Harold, Denise H. and Naj, Adam Christian and Sims, Rebecca and Bellenguez, Céline and others}, title = {{Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease}}, journal = {Nature Genetics}, year = {2013}, doi = {10.1038/ng.2802}, pmid = {24162737}, url = {https://doi.org/10.1038/ng.2802} } @article{giorgio2026-41936382, author = {Giorgio, Katherine and Stephen, John J and Mansolf, Maxwell and Peterson, Elizabeth A and Gross, Alden L and Briceño, Emily M and Levine, Deborah A and Helmer, Catherine and others}, title = {{Risk factors for early-onset and late-onset dementia: a prospective cohort study}}, journal = {The lancet. Healthy longevity}, year = {2026}, doi = {10.1016/j.lanhl.2026.100831}, pmid = {41936382}, url = {https://doi.org/10.1016/j.lanhl.2026.100831} } @article{schrijvers2010-21115952, author = {Schrijvers, E. M. and Witteman, J. C. and Sijbrands, E. J. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181ffe4f6}, pmid = {21115952}, url = {https://doi.org/10.1212/wnl.0b013e3181ffe4f6} } @article{engelhart2002-12499483, author = {Engelhart, M. J. and Geerlings, M. I. and Ruitenberg, A. and Van Swieten, J. C. and Hofman, A. and Witteman, J. C. and Breteler, M. M.}, title = {{Diet and risk of dementia: Does fat matter?: The Rotterdam Study}}, journal = {Neurology}, year = {2002}, doi = {10.1212/01.wnl.0000038345.77753.46}, pmid = {12499483}, url = {https://doi.org/10.1212/01.wnl.0000038345.77753.46} } @article{dimarco2014-24799342, author = {Di Marco, L. Y. and Marzo, A. and Muñoz-Ruiz, M. and Ikram, M. A. and Kivipelto, M. and Ruefenacht, D. and Venneri, A. and Soininen, H. and others}, title = {{Modifiable lifestyle factors in dementia: a systematic review of longitudinal observational cohort studies}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2014}, doi = {10.3233/jad-132225}, pmid = {24799342}, url = {https://doi.org/10.3233/jad-132225} } @article{rascovsky2011-21810890, author = {Rascovsky, K. and Hodges, JR. and Knopman, D. and Mendez, M. F. and Kramer, J. H. and Neuhaus, J. and van Swieten, J. C. and Seelaar, H. and others}, title = {{Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia}}, journal = {Brain : a journal of neurology}, year = {2011}, doi = {10.1093/brain/awr179}, pmid = {21810890}, url = {https://doi.org/10.1093/brain/awr179} } @article{fathy2020-31011951, author = {Fathy, Y. Y. and Hoogers, S. E. and Berendse, H. W. and van der Werf, Y. D. and Visser, P. J. and de Jong, F. J. and van de Berg, W. D. J.}, title = {{Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis}}, journal = {Brain imaging and behavior}, year = {2020}, doi = {10.1007/s11682-019-00099-3}, pmid = {31011951}, url = {https://doi.org/10.1007/s11682-019-00099-3} } @article{debruijn2015-26389654, author = {de Bruijn, R. F. and Heeringa, J. and Wolters, F. J. and Franco, O. H. and Stricker, B. H. and Hofman, A. and Koudstaal, P. J. and Ikram, M. A.}, title = {{Association Between Atrial Fibrillation and Dementia in the General Population}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2015.2161}, pmid = {26389654}, url = {https://doi.org/10.1001/jamaneurol.2015.2161} } @article{mauschitz2018-29716786, author = {Mauschitz, M. M. and Bonnemaijer, P. W. M. and Diers, K. and Rauscher, F. G. and Elze, T. and Engel, C. and Loeffler, M. and Colijn, J. M. and others}, title = {{Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population}}, journal = {Ophthalmology}, year = {2018}, doi = {10.1016/j.ophtha.2018.03.026}, pmid = {29716786}, url = {https://doi.org/10.1016/j.ophtha.2018.03.026} } @article{hilal2017-28984600, author = {Hilal, S. and Akoudad, S. and van Duijn, C. M. and Niessen, W. J. and Verbeek, M. M. and Vanderstichele, H. and Stoops, E. and Ikram, M. A. and others}, title = {{Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-170458}, pmid = {28984600}, url = {https://doi.org/10.3233/jad-170458} } @article{voortman2017-28825166, author = {Voortman, T. and Kiefte-de Jong, J. C. and Ikram, M. A. and Stricker, B. H. and van Rooij, F. J. A. and Lahousse, L. and Tiemeier, H. and Brusselle, G. G. and others}, title = {{Adherence to the 2015 Dutch dietary guidelines and risk of non-communicable diseases and mortality in the Rotterdam Study}}, journal = {European journal of epidemiology}, year = {2017}, doi = {10.1007/s10654-017-0295-2}, pmid = {28825166}, url = {https://doi.org/10.1007/s10654-017-0295-2} } @article{vanes2009-19734901, author = {van Es, M. A. and Veldink, J. H. and Saris, C. G. and Blauw, H. M. and van Vught, P. W. and Birve, A. and Lemmens, R. and Schelhaas, H. J. and others}, title = {{Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis}}, journal = {Nature genetics}, year = {2009}, doi = {10.1038/ng.442}, pmid = {19734901}, url = {https://doi.org/10.1038/ng.442} } @article{cruts2006-16862115, author = {Cruts, M. and Gijselinck, I. and van der Zee, J. and Engelborghs, S. and Wils, H. and Pirici, D. and Rademakers, R. and others}, title = {{Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21}}, journal = {Nature}, year = {2006}, doi = {10.1038/nature05017}, pmid = {16862115}, url = {https://doi.org/10.1038/nature05017} } @article{ott2004-15037693, author = {Ott, A. and Andersen, K. and Dewey, M. E. and Letenneur, L. and Brayne, C. and Copeland, JR. and Dartigues, J. F. and Kragh-Sorensen, P. and others}, title = {{Effect of smoking on global cognitive function in nondemented elderly}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000115110.35610.80}, pmid = {15037693}, url = {https://doi.org/10.1212/01.wnl.0000115110.35610.80} } @article{ott1998-9521184, author = {Ott, A. and Breteler, M. M. and van Harskamp, F. and Stijnen, T. and Hofman, A.}, title = {{Incidence and risk of dementia. The Rotterdam Study}}, journal = {American journal of epidemiology}, year = {1998}, doi = {10.1093/oxfordjournals.aje.a009489}, pmid = {9521184}, url = {https://doi.org/10.1093/oxfordjournals.aje.a009489} } @article{vanoijen2007-17328068, author = {van Oijen, M. and de Jong, F. J. and Witteman, J. C. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Atherosclerosis and risk for dementia}}, journal = {Annals of neurology}, year = {2007}, doi = {10.1002/ana.21073}, pmid = {17328068}, url = {https://doi.org/10.1002/ana.21073} } @article{devore2010-20625087, author = {Devore, E. E. and Grodstein, F. and van Rooij, F. J. and Hofman, A. and Stampfer, M. J. and Witteman, J. C. and Breteler, M. M.}, title = {{Dietary antioxidants and long-term risk of dementia}}, journal = {Archives of neurology}, year = {2010}, doi = {10.1001/archneurol.2010.144}, pmid = {20625087}, url = {https://doi.org/10.1001/archneurol.2010.144} } @article{vanoijen2005-16269641, author = {van Oijen, M. and Witteman, J. C. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia}}, journal = {Stroke}, year = {2005}, doi = {10.1161/01.str.0000189721.31432.26}, pmid = {16269641}, url = {https://doi.org/10.1161/01.str.0000189721.31432.26} } @article{chen2021-33416887, author = {Chen, J. and Mooldijk, S. S. and Licher, S. and Waqas, K. and Ikram, M. K. and Uitterlinden, A. G. and Zillikens, M. C. and Ikram, M. A.}, title = {{Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia}}, journal = {JAMA network open}, year = {2021}, doi = {10.1001/jamanetworkopen.2020.33012}, pmid = {33416887}, url = {https://doi.org/10.1001/jamanetworkopen.2020.33012} } @article{qian2017-28323826, author = {Qian, J. and Wolters, F. J. and Beiser, A. and Haan, M. and Ikram, M. A. and Karlawish, J. and Langbaum, J. B. and Neuhaus, J. M. and others}, title = {{APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts}}, journal = {PLoS medicine}, year = {2017}, doi = {10.1371/journal.pmed.1002254}, pmid = {28323826}, url = {https://doi.org/10.1371/journal.pmed.1002254} } @article{licher2019-31451782, author = {Licher, S. and Ahmad, S. and Karamujić-Čomić, H. and Voortman, T. and Leening, M. J. G. and Ikram, M. A. and Ikram, M. K.}, title = {{Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population}}, journal = {Nature medicine}, year = {2019}, doi = {10.1038/s41591-019-0547-7}, pmid = {31451782}, url = {https://doi.org/10.1038/s41591-019-0547-7} } @article{deleeuw2002-11912110, author = {de Leeuw, F. E. and de Groot, J. C. and Oudkerk, M. and Witteman, J. C. and Hofman, A. and van Gijn, J. and Breteler, M. M.}, title = {{Hypertension and cerebral white matter lesions in a prospective cohort study}}, journal = {Brain : a journal of neurology}, year = {2002}, doi = {10.1093/brain/awf077}, pmid = {11912110}, url = {https://doi.org/10.1093/brain/awf077} } @article{prins2004-15477506, author = {Prins, N. D. and van Dijk, E. J. and den Heijer, T. and Vermeer, S. E. and Koudstaal, P. J. and Oudkerk, M. and Hofman, A. and Breteler, M. M.}, title = {{Cerebral white matter lesions and the risk of dementia}}, journal = {Archives of neurology}, year = {2004}, doi = {10.1001/archneur.61.10.1531}, pmid = {15477506}, url = {https://doi.org/10.1001/archneur.61.10.1531} } @article{renton2011-21944779, author = {Renton, A. E. and Majounie, E. and Waite, A. and Simón-Sánchez, J. and Rollinson, S. and Gibbs, JR. and Schymick, J. C. and Laaksovirta, H. and others}, title = {{A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD}}, journal = {Neuron}, year = {2011}, doi = {10.1016/j.neuron.2011.09.010}, pmid = {21944779}, url = {https://doi.org/10.1016/j.neuron.2011.09.010} } @article{skoog2005-16109319, author = {Skoog, I. and Lithell, H. and Hansson, L. and Elmfeldt, D. and Hofman, A. and Olofsson, B. and Trenkwalder, P. and Zanchetti, A. and others}, title = {{Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE)}}, journal = {American journal of hypertension}, year = {2005}, doi = {10.1016/j.amjhyper.2005.02.013}, pmid = {16109319}, url = {https://doi.org/10.1016/j.amjhyper.2005.02.013} } @article{mirza2025-40260680, author = {Mirza, Saira Saeed and Pasternak, Maurice M. and Paterson, Andrew D. and Rogaeva, Ekaterina A. and Tartaglia, Maria Carmela and Mitchell, Sara Berman and Black, Sandra E. and Freedman, Morris and others}, title = {{Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study}}, journal = {Brain}, year = {2025}, doi = {10.1093/brain/awaf019}, pmid = {40260680}, url = {https://doi.org/10.1093/brain/awaf019} } @article{honey2026-41986736, author = {Honey, Madison I. J. and Hok-A-Hin, Yanaika Sylvana and Thijssen, Elisabeth H. and Cousins, Katheryn A Q and van der Weijden, Babette and Veld, Lisanne in ‘t and Stoops, Erik and de Boer, Sterre C.M. and others}, title = {{An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration}}, journal = {Nature Medicine}, year = {2026}, doi = {10.1038/s41591-026-04341-6}, pmid = {41986736}, url = {https://doi.org/10.1038/s41591-026-04341-6} } @article{winblad2004-15324367, author = {Winblad, Bengt G. and Palmer, Katie and Kivipelto, Miia and Jelić, Vesna and Fratiglioni, Laura and Wahlund, Lars‐Olof and Nordberg, Agneta K. and Bäckman, Lars and others}, title = {{Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment}}, journal = {Journal of Internal Medicine}, year = {2004}, doi = {10.1111/j.1365-2796.2004.01380.x}, pmid = {15324367}, url = {https://doi.org/10.1111/j.1365-2796.2004.01380.x} } @article{vernooij2009-19620607, author = {Vernooij, M. W. and Ikram, M. A. and Hofman, A. and Krestin, G. P. and Breteler, M. M. and van der Lugt, A.}, title = {{Superficial siderosis in the general population}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181ae7c5e}, pmid = {19620607}, url = {https://doi.org/10.1212/wnl.0b013e3181ae7c5e} } @article{greenberg2009-19161908, author = {Greenberg, S. M. and Vernooij, M. W. and Cordonnier, C. and Viswanathan, A. and Al-Shahi Salman, R. and Warach, S. and Launer, L. J. and Van Buchem, M. A. and others}, title = {{Cerebral microbleeds: a guide to detection and interpretation}}, journal = {The Lancet. Neurology}, year = {2009}, doi = {10.1016/s1474-4422(09)70013-4}, pmid = {19161908}, url = {https://doi.org/10.1016/s1474-4422(09)70013-4} } @article{hofman1997-9111537, author = {Hofman, A. and Ott, A. and Breteler, M. M. and Bots, M. L. and Slooter, A. J. and van Harskamp, F. and van Duijn, C. N. and Van Broeckhoven, C. and others}, title = {{Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study}}, journal = {Lancet (London, England)}, year = {1997}, doi = {10.1016/s0140-6736(96)09328-2}, pmid = {9111537}, url = {https://doi.org/10.1016/s0140-6736(96)09328-2} } @article{ott1995-7728032, author = {Ott, A. and Breteler, M. M. and van Harskamp, F. and Claus, J. J. and van der Cammen, T. J. and Grobbee, D. E. and Hofman, A.}, title = {{Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study}}, journal = {BMJ (Clinical research ed.)}, year = {1995}, doi = {10.1136/bmj.310.6985.970}, pmid = {7728032}, url = {https://doi.org/10.1136/bmj.310.6985.970} } @article{akoudad2016-27271785, author = {Akoudad, S. and Wolters, F. J. and Viswanathan, A. and de Bruijn, R. F. and van der Lugt, A. and Hofman, A. and Koudstaal, P. J. and Ikram, M. A. and others}, title = {{Association of Cerebral Microbleeds With Cognitive Decline and Dementia}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.1017}, pmid = {27271785}, url = {https://doi.org/10.1001/jamaneurol.2016.1017} } @article{rohrer2015-25662776, author = {Rohrer, J. D. and Nicholas, J. M. and Cash, D. M. and van Swieten, J. and Dopper, E. and Jiskoot, L. and van Minkelen, R. and Rombouts, S. A. and others}, title = {{Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis}}, journal = {The Lancet. Neurology}, year = {2015}, doi = {10.1016/s1474-4422(14)70324-2}, pmid = {25662776}, url = {https://doi.org/10.1016/s1474-4422(14)70324-2} } @article{ruitenberg2001-11125239, author = {Ruitenberg, A. and Skoog, I. and Ott, A. and Aevarsson, O. and Witteman, J. C. and Lernfelt, B. and van Harskamp, F. and Hofman, A. and others}, title = {{Blood pressure and risk of dementia: results from the Rotterdam study and the Gothenburg H-70 Study}}, journal = {Dementia and geriatric cognitive disorders}, year = {2001}, doi = {10.1159/000051233}, pmid = {11125239}, url = {https://doi.org/10.1159/000051233} } @article{delau2005-15985568, author = {de Lau, L. M. and Bornebroek, M. and Witteman, J. C. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study}}, journal = {Neurology}, year = {2005}, doi = {10.1212/01.wnl.0000166038.67153.9f}, pmid = {15985568}, url = {https://doi.org/10.1212/01.wnl.0000166038.67153.9f} } @article{weinstein2019-30768625, author = {Weinstein, G. and Davis-Plourde, K. L. and Conner, S. and Himali, J. J. and Beiser, A. S. and Lee, A. and Rawlings, A. M. and Sedaghat, S. and others}, title = {{Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts}}, journal = {PloS one}, year = {2019}, doi = {10.1371/journal.pone.0212293}, pmid = {30768625}, url = {https://doi.org/10.1371/journal.pone.0212293} } @article{deboer2025-39951678, author = {de Boer, Liset and Poos, Jackie M. and van den Berg, Esther and De Houwer, Julie F. H. and Swartenbroekx, Tine and Dopper, Elise G.P. and Boesjes, Pam and Tahboun, Najlae and others}, title = {{Montreal Cognitive Assessment vs the Mini-Mental State Examination as a Screening Tool for Patients With Genetic Frontotemporal Dementia}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213401}, pmid = {39951678}, url = {https://doi.org/10.1212/wnl.0000000000213401} } @article{jiang2026-42127901, author = {Jiang, F. and Dong, Q. and Jayakody, D. M. P. and Chen, X. and Mueller, C. and Wu, B. and others}, title = {{Hearing aid effectiveness and probable dementia risk across 33 countries: A pooled analysis of seven cohorts}}, journal = {Cell Reports Medicine}, year = {2026}, doi = {10.1016/j.xcrm.2026.102802}, pmid = {42127901}, url = {https://doi.org/10.1016/j.xcrm.2026.102802} } @article{nicolas2025-40533518, author = {Nicolas, A. and Sherva, R. and Grenier-Boley, B. and Kim, Y. and Kikuchi, M. and Timsina, J. and de Rojas, I. and Dalmasso, M. C. and Zhou, X. and Le Guen, Y. and Arboleda-Bustos, C. E. and Camargos Bicalho, M. A. and others}, title = {{Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations}}, journal = {Nature genetics}, year = {2025}, doi = {10.1038/s41588-025-02227-w}, pmid = {40533518}, url = {https://doi.org/10.1038/s41588-025-02227-w} } @article{geerlings2001-11255424, author = {Geerlings, M. I. and Ruitenberg, A. and Witteman, J. C. and van Swieten, J. C. and Hofman, A. and van Duijn, C. M. and Breteler, M. M. and Launer, L. J.}, title = {{Reproductive period and risk of dementia in postmenopausal women}}, journal = {JAMA}, year = {2001}, doi = {10.1001/jama.285.11.1475}, pmid = {11255424}, url = {https://doi.org/10.1001/jama.285.11.1475} } @article{wolters2019-31366722, author = {Wolters, F. J. and Zonneveld, H. I. and Licher, S. and Cremers, L. G. M. and {Heart Brain Connection Collaborative Research Group} and Ikram, M. K. and Koudstaal, P. J. and Vernooij, M. W. and others}, title = {{Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI}}, journal = {Neurology}, year = {2019}, doi = {10.1212/wnl.0000000000008003}, pmid = {31366722}, url = {https://doi.org/10.1212/wnl.0000000000008003} } @article{engelhart2004-15148142, author = {Engelhart, M. J. and Geerlings, M. I. and Meijer, J. and Kiliaan, A. and Ruitenberg, A. and van Swieten, J. C. and Stijnen, T. and Hofman, A. and others}, title = {{Inflammatory proteins in plasma and the risk of dementia: the rotterdam study}}, journal = {Archives of neurology}, year = {2004}, doi = {10.1001/archneur.61.5.668}, pmid = {15148142}, url = {https://doi.org/10.1001/archneur.61.5.668} } @article{verhaar2021-35173707, author = {Verhaar, B. J. H. and Hendriksen, H. M. A. and de Leeuw, F. A. and Doorduijn, A. S. and van Leeuwenstijn, M. and Teunissen, C. E. and Barkhof, F. and Scheltens, P. and others}, title = {{Gut Microbiota Composition Is Related to AD Pathology}}, journal = {Frontiers in immunology}, year = {2021}, doi = {10.3389/fimmu.2021.794519}, pmid = {35173707}, url = {https://doi.org/10.3389/fimmu.2021.794519} } @article{young2021-34158384, author = {Young, A. L. and Bocchetta, M. and Russell, L. L. and Convery, R. S. and Peakman, G. and Todd, E. and Cash, D. M. and Greaves, C. V. and others}, title = {{Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012410}, pmid = {34158384}, url = {https://doi.org/10.1212/wnl.0000000000012410} } @article{vermeer2002-11891822, author = {Vermeer, S. E. and van Dijk, E. J. and Koudstaal, P. J. and Oudkerk, M. and Hofman, A. and Clarke, R. and Breteler, M. M.}, title = {{Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study}}, journal = {Annals of neurology}, year = {2002}, doi = {10.1002/ana.10111}, pmid = {11891822}, url = {https://doi.org/10.1002/ana.10111} } @article{ruitenberg2002-11830193, author = {Ruitenberg, A. and van Swieten, J. C. and Witteman, J. C. and Mehta, K. M. and van Duijn, C. M. and Hofman, A. and Breteler, M. M.}, title = {{Alcohol consumption and risk of dementia: the Rotterdam Study}}, journal = {Lancet (London, England)}, year = {2002}, doi = {10.1016/s0140-6736(02)07493-7}, pmid = {11830193}, url = {https://doi.org/10.1016/s0140-6736(02)07493-7} } @article{blackman2022-36337343, author = {Blackman, J. and Stankeviciute, L. and Arenaza-Urquijo, E. M. and Suárez-Calvet, M. and Sánchez-Benavides, G. and Vilor-Tejedor, N. and Iranzo, A. and Molinuevo, J. L. and others}, title = {{Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults}}, journal = {Brain communications}, year = {2022}, doi = {10.1093/braincomms/fcac257}, pmid = {36337343}, url = {https://doi.org/10.1093/braincomms/fcac257} } @article{ruitenberg2001-11445258, author = {Ruitenberg, A. and Ott, A. and van Swieten, J. C. and Hofman, A. and Breteler, M. M.}, title = {{Incidence of dementia: does gender make a difference?}}, journal = {Neurobiology of aging}, year = {2001}, doi = {10.1016/s0197-4580(01)00231-7}, pmid = {11445258}, url = {https://doi.org/10.1016/s0197-4580(01)00231-7} } @article{vanoijen2007-19595922, author = {van Oijen, M. and de Jong, F. J. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Subjective memory complaints, education, and risk of Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2007}, doi = {10.1016/j.jalz.2007.01.011}, pmid = {19595922}, url = {https://doi.org/10.1016/j.jalz.2007.01.011} } @article{croll2018-29769374, author = {Croll, P. H. and Voortman, T. and Ikram, M. A. and Franco, O. H. and Schoufour, J. D. and Bos, D. and Vernooij, M. W.}, title = {{Better diet quality relates to larger brain tissue volumes: The Rotterdam Study}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005691}, pmid = {29769374}, url = {https://doi.org/10.1212/wnl.0000000000005691} } @article{yuan2025-40461148, author = {Yuan, Shuai and Zhang, Fengying and Pu, Lihui and Lv, Juan and Xie, Xiaofeng and Lin, Lin and Qiu, Mengying and Huang, Lei and others}, title = {{Social support interventions for caregivers of older adults with dementia: a scoping review}}, journal = {BMJ Open}, year = {2025}, doi = {10.1136/bmjopen-2024-095815}, pmid = {40461148}, url = {https://doi.org/10.1136/bmjopen-2024-095815} } @article{debruijn2015-26195085, author = {de Bruijn, R. F. and Bos, M. J. and Portegies, M. L. and Hofman, A. and Franco, O. H. and Koudstaal, P. J. and Ikram, M. A.}, title = {{The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study}}, journal = {BMC medicine}, year = {2015}, doi = {10.1186/s12916-015-0377-5}, pmid = {26195085}, url = {https://doi.org/10.1186/s12916-015-0377-5} } @article{vanderlee2018-29316447, author = {van der Lee, S. J. and Teunissen, C. E. and Pool, R. and Shipley, M. J. and Teumer, A. and Chouraki, V. and Melo van Lent, D. and Tynkkynen, J. and others}, title = {{Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2018}, doi = {10.1016/j.jalz.2017.11.012}, pmid = {29316447}, url = {https://doi.org/10.1016/j.jalz.2017.11.012} } @article{ott1997-9040682, author = {Ott, A. and Breteler, M. M. and de Bruyne, M. C. and van Harskamp, F. and Grobbee, D. E. and Hofman, A.}, title = {{Atrial fibrillation and dementia in a population-based study. The Rotterdam Study}}, journal = {Stroke}, year = {1997}, doi = {10.1161/01.str.28.2.316}, pmid = {9040682}, url = {https://doi.org/10.1161/01.str.28.2.316} } @article{mehta1999-10599765, author = {Mehta, K. M. and Ott, A. and Kalmijn, S. and Slooter, A. J. and van Duijn, C. M. and Hofman, A. and Breteler, M. M.}, title = {{Head trauma and risk of dementia and Alzheimer's disease: The Rotterdam Study}}, journal = {Neurology}, year = {1999}, doi = {10.1212/wnl.53.9.1959}, pmid = {10599765}, url = {https://doi.org/10.1212/wnl.53.9.1959} } @article{chaker2016-27638924, author = {Chaker, L. and Wolters, F. J. and Bos, D. and Korevaar, T. I. and Hofman, A. and van der Lugt, A. and Koudstaal, P. J. and Franco, O. H. and others}, title = {{Thyroid function and the risk of dementia: The Rotterdam Study}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000003227}, pmid = {27638924}, url = {https://doi.org/10.1212/wnl.0000000000003227} } @article{mirza2017-27520773, author = {Mirza, S. S. and Ikram, M. A. and Bos, D. and Mihaescu, R. and Hofman, A. and Tiemeier, H.}, title = {{Mild cognitive impairment and risk of depression and anxiety: A population-based study}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.06.2361}, pmid = {27520773}, url = {https://doi.org/10.1016/j.jalz.2016.06.2361} } @article{freakpoli2022-34842183, author = {Freak-Poli, R. and Wagemaker, N. and Wang, R. and Lysen, T. S. and Ikram, M. A. and Vernooij, M. W. and Dintica, C. S. and Vernooij-Dassen, M. and others}, title = {{Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2022}, doi = {10.3233/jad-210330}, pmid = {34842183}, url = {https://doi.org/10.3233/jad-210330} } @article{wolters2017-28356461, author = {Wolters, F. J. and van der Lee, S. J. and Koudstaal, P. J. and van Duijn, C. M. and Hofman, A. and Ikram, M. K. and Vernooij, M. W. and Ikram, M. A.}, title = {{Parental family history of dementia in relation to subclinical brain disease and dementia risk}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000003871}, pmid = {28356461}, url = {https://doi.org/10.1212/wnl.0000000000003871} } @article{deleeuw2001-11118240, author = {de Leeuw, F. E. and de Groot, J. C. and Achten, E. and Oudkerk, M. and Ramos, L. M. and Heijboer, R. and Hofman, A. and Jolles, J. and others}, title = {{Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2001}, doi = {10.1136/jnnp.70.1.9}, pmid = {11118240}, url = {https://doi.org/10.1136/jnnp.70.1.9} } @article{vandijk2004-15466662, author = {van Dijk, E. J. and Breteler, M. M. and Schmidt, R. and Berger, K. and Nilsson, L. G. and Oudkerk, M. and Pajak, A. and Sans, S. and others}, title = {{The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2004}, doi = {10.1161/01.hyp.0000145857.98904.20}, pmid = {15466662}, url = {https://doi.org/10.1161/01.hyp.0000145857.98904.20} } @article{delau2005-16087767, author = {de Lau, L. M. and Schipper, C. M. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study}}, journal = {Archives of neurology}, year = {2005}, doi = {10.1001/archneur.62.8.1265}, pmid = {16087767}, url = {https://doi.org/10.1001/archneur.62.8.1265} } @article{delau2006-16864826, author = {de Lau, L. M. and Koudstaal, P. J. and Witteman, J. C. and Hofman, A. and Breteler, M. M.}, title = {{Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000225050.57553.6d}, pmid = {16864826}, url = {https://doi.org/10.1212/01.wnl.0000225050.57553.6d} } @article{luo2023-37195665, author = {Luo, J. and Thomassen, J. Q. and Bellenguez, C. and Grenier-Boley, B. and de Rojas, I. and Castillo, A. and Parveen, K. and others}, title = {{Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.13734}, pmid = {37195665}, url = {https://doi.org/10.1001/jamanetworkopen.2023.13734} } @article{lysen2020-32558256, author = {Lysen, T. S. and Luik, A. I. and Ikram, M. K. and Tiemeier, H. and Ikram, M. A.}, title = {{Actigraphy-estimated sleep and 24-hour activity rhythms and the risk of dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2020}, doi = {10.1002/alz.12122}, pmid = {32558256}, url = {https://doi.org/10.1002/alz.12122} } @article{hilal2018-30355213, author = {Hilal, S. and Ikram, M. A. and Verbeek, M. M. and Franco, O. H. and Stoops, E. and Vanderstichele, H. and Niessen, W. J. and Vernooij, M. W.}, title = {{C-Reactive Protein, Plasma Amyloid-β Levels, and Their Interaction With Magnetic Resonance Imaging Markers}}, journal = {Stroke}, year = {2018}, doi = {10.1161/strokeaha.118.022317}, pmid = {30355213}, url = {https://doi.org/10.1161/strokeaha.118.022317} } @article{donkerkaat2009-19458322, author = {Donker Kaat, L. and Boon, A. J. and Azmani, A. and Kamphorst, W. and Breteler, M. M. and Anar, B. and Heutink, P. and van Swieten, J. C.}, title = {{Familial aggregation of parkinsonism in progressive supranuclear palsy}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181a92bcc}, pmid = {19458322}, url = {https://doi.org/10.1212/wnl.0b013e3181a92bcc} } @article{hoglinger2017-28467028, author = {Höglinger, Günter U. and Respondek, Gesine and Stamelou, María and Kurz, Carolin and Josephs, Keith A. and Lang, Anthony E. and Mollenhauer, Brit and Müller, Ulrich and Nilsson, Christer and Whitwell, Jennifer L. and Arzberger, Thomas and Englund, Elisabet M. and Gelpí, Ellen and Giese, Armin and Irwin, David John and Meissner, Wassilios G. and Pantelyat, Alexander Y. and Rajput, Alex H. and Van Swieten, John Cornelis and Troakes, Claire and Antonini, Angelo and Bhatia, Kailash P. and Bordelon, Yvette M. and Compta, Yaroslau and Corvol, Jean‐Christophe and Colosimo, Carlo and Dickson, Dennis W. and Dodel, Richard C. and Ferguson, Leslie W. and Grossman, Murray and Kassubek, Jan and Krismer, Florian and Levin, Johannes and Lorenzl, Stefan and Morris, Huw R. and Nestor, Peter J. and Oertel, Wolfgang H. and Poewe, Werner H and Rabinovici, Gil D. and Rowe, James Benedict and Schellenberg, Gerard D. and Seppi, Klaus and van Eimeren, Thilo and Wenning, Gregor Karl and Boxer, Adam L. and Golbe, Lawrence I. and Litvan, Irene and {Movement Disorder Society–endorsed PSP Study Group}}, title = {{Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria}}, journal = {Movement Disorders}, year = {2017}, doi = {10.1002/mds.26987}, pmid = {28467028}, url = {https://doi.org/10.1002/mds.26987} } @article{frisoni2022-34815562, author = {Frisoni, G. B. and Altomare, D. and Thal, D. R. and Ribaldi, F. and van der Kant, R. and Ossenkoppele, R. and Blennow, K. and Cummings, J. and others}, title = {{The probabilistic model of Alzheimer disease: the amyloid hypothesis revised}}, journal = {Nature reviews. Neuroscience}, year = {2022}, doi = {10.1038/s41583-021-00533-w}, pmid = {34815562}, url = {https://doi.org/10.1038/s41583-021-00533-w} } @article{dejong2006-16636121, author = {de Jong, F. J. and den Heijer, T. and Visser, T. J. and de Rijke, Y. B. and Drexhage, H. A. and Hofman, A. and Breteler, M. M.}, title = {{Thyroid hormones, dementia, and atrophy of the medial temporal lobe}}, journal = {The Journal of clinical endocrinology and metabolism}, year = {2006}, doi = {10.1210/jc.2006-0449}, pmid = {16636121}, url = {https://doi.org/10.1210/jc.2006-0449} } @article{ott1996-8933010, author = {Ott, A. and Stolk, R. P. and Hofman, A. and van Harskamp, F. and Grobbee, D. E. and Breteler, M. M.}, title = {{Association of diabetes mellitus and dementia: the Rotterdam Study}}, journal = {Diabetologia}, year = {1996}, doi = {10.1007/s001250050588}, pmid = {8933010}, url = {https://doi.org/10.1007/s001250050588} } @article{poels2012-22262748, author = {Poels, M. M. and Ikram, M. A. and van der Lugt, A. and Hofman, A. and Niessen, W. J. and Krestin, G. P. and Breteler, M. M. and Vernooij, M. W.}, title = {{Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182452928}, pmid = {22262748}, url = {https://doi.org/10.1212/wnl.0b013e3182452928} } @article{ruitenberg2005-15929050, author = {Ruitenberg, A. and den Heijer, T. and Bakker, S. L. and van Swieten, J. C. and Koudstaal, P. J. and Hofman, A. and Breteler, M. M.}, title = {{Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study}}, journal = {Annals of neurology}, year = {2005}, doi = {10.1002/ana.20493}, pmid = {15929050}, url = {https://doi.org/10.1002/ana.20493} } @article{wang2019-31575746, author = {Wang, J. and Knol, M. J. and Tiulpin, A. and Dubost, F. and de Bruijne, M. and Vernooij, M. W. and Adams, H. H. H. and Ikram, M. A. and others}, title = {{Gray Matter Age Prediction as a Biomarker for Risk of Dementia}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2019}, doi = {10.1073/pnas.1902376116}, pmid = {31575746}, url = {https://doi.org/10.1073/pnas.1902376116} } @article{wolters2016-27727284, author = {Wolters, F. J. and Mattace-Raso, F. U. and Koudstaal, P. J. and Hofman, A. and Ikram, M. A. and {Heart Brain Connection Collaborative Research Group}}, title = {{Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study}}, journal = {PLoS medicine}, year = {2016}, doi = {10.1371/journal.pmed.1002143}, pmid = {27727284}, url = {https://doi.org/10.1371/journal.pmed.1002143} } @article{evans2018-29778641, author = {Evans, T. E. and Adams, H. H. H. and Licher, S. and Wolters, F. J. and van der Lugt, A. and Ikram, M. K. and O'Sullivan, M. J. and Vernooij, M. W. and others}, title = {{Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia}}, journal = {NeuroImage}, year = {2018}, doi = {10.1016/j.neuroimage.2018.05.041}, pmid = {29778641}, url = {https://doi.org/10.1016/j.neuroimage.2018.05.041} } @article{licher2017-28984598, author = {Licher, S. and de Bruijn, R. F. A. G. and Wolters, F. J. and Zillikens, M. C. and Ikram, M. A. and Ikram, M. K.}, title = {{Vitamin D and the Risk of Dementia: The Rotterdam Study}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-170407}, pmid = {28984598}, url = {https://doi.org/10.3233/jad-170407} } @article{schrijvers2012-22786586, author = {Schrijvers, E. M. and Buitendijk, G. H. and Ikram, M. K. and Koudstaal, P. J. and Hofman, A. and Vingerling, JR. and Breteler, M. M.}, title = {{Retinopathy and risk of dementia: the Rotterdam Study}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e318260cd7e}, pmid = {22786586}, url = {https://doi.org/10.1212/wnl.0b013e318260cd7e} } @article{wolters2016-26586657, author = {Wolters, F. J. and de Bruijn, R. F. and Hofman, A. and Koudstaal, P. J. and Ikram, M. A. and {Heart Brain Connection Collaborative Research Group}}, title = {{Cerebral Vasoreactivity, Apolipoprotein E, and the Risk of Dementia: A Population-Based Study}}, journal = {Arteriosclerosis, thrombosis, and vascular biology}, year = {2016}, doi = {10.1161/atvbaha.115.306768}, pmid = {26586657}, url = {https://doi.org/10.1161/atvbaha.115.306768} } @article{hendriks1992-1303239, author = {Hendriks, L. and van Duijn, C. M. and Cras, P. and Cruts, M. and Van Hul, W. and van Harskamp, F. and Warren, A. and McInnis, M. G. and others}, title = {{Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene}}, journal = {Nature genetics}, year = {1992}, doi = {10.1038/ng0692-218}, pmid = {1303239}, url = {https://doi.org/10.1038/ng0692-218} } @article{chouraki2014-24535457, author = {Chouraki, V. and De Bruijn, R. F. and Chapuis, J. and Bis, J. C. and Reitz, C. and Schraen, S. and Ibrahim-Verbaas, C. A. and Grenier-Boley, B. and others}, title = {{A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly}}, journal = {Molecular psychiatry}, year = {2014}, doi = {10.1038/mp.2013.185}, pmid = {24535457}, url = {https://doi.org/10.1038/mp.2013.185} } @article{quenez2026-42648288, author = {Quenez, O. and Schramm, C. and Cassinari, K. and Nicolas, A. and Groeneveld, J. and Huguet, G. and Grenier-Boley, B. and Hulsman, M. and Walters, G. B. and de Rojas, I. and Rovelet-Lecrux, A. and Feuillette, S. and others}, title = {{Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk}}, journal = {American Journal of Human Genetics}, year = {2026}, doi = {10.1016/j.ajhg.2026.07.013}, pmid = {42648288}, url = {https://doi.org/10.1016/j.ajhg.2026.07.013} } @article{geerlings2008-18391157, author = {Geerlings, M. I. and den Heijer, T. and Koudstaal, P. J. and Hofman, A. and Breteler, M. M.}, title = {{History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000308937.30473.d1}, pmid = {18391157}, url = {https://doi.org/10.1212/01.wnl.0000308937.30473.d1} } @article{wu2017-28497805, author = {Wu, Y. T. and Beiser, A. S. and Breteler, M. M. B. and Fratiglioni, L. and Helmer, C. and Hendrie, H. C. and Honda, H. and Ikram, M. A. and others}, title = {{The changing prevalence and incidence of dementia over time - current evidence}}, journal = {Nature reviews. Neurology}, year = {2017}, doi = {10.1038/nrneurol.2017.63}, pmid = {28497805}, url = {https://doi.org/10.1038/nrneurol.2017.63} } @article{heller2020-31937580, author = {Heller, C. and Foiani, M. S. and Moore, K. and Convery, R. and Bocchetta, M. and Neason, M. and Cash, D. M. and Thomas, D. and others}, title = {{Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2020}, doi = {10.1136/jnnp-2019-321954}, pmid = {31937580}, url = {https://doi.org/10.1136/jnnp-2019-321954} } @article{breteler1994-8025427, author = {Breteler, M. M. and Claus, J. J. and Grobbee, D. E. and Hofman, A.}, title = {{Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam Study}}, journal = {BMJ (Clinical research ed.)}, year = {1994}, doi = {10.1136/bmj.308.6944.1604}, pmid = {8025427}, url = {https://doi.org/10.1136/bmj.308.6944.1604} } @article{ikram2008-18323497, author = {Ikram, M. A. and van Oijen, M. and de Jong, F. J. and Kors, J. A. and Koudstaal, P. J. and Hofman, A. and Witteman, J. C. and Breteler, M. M.}, title = {{Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease}}, journal = {Stroke}, year = {2008}, doi = {10.1161/strokeaha.107.501106}, pmid = {18323497}, url = {https://doi.org/10.1161/strokeaha.107.501106} } @article{licher2019-30525906, author = {Licher, S. and Leening, M. J. G. and Yilmaz, P. and Wolters, F. J. and Heeringa, J. and Bindels, P. J. E. and {Alzheimer’s Disease Neuroimaging Initiative} and Vernooij, M. W. and others}, title = {{Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies}}, journal = {The American journal of psychiatry}, year = {2019}, doi = {10.1176/appi.ajp.2018.18050566}, pmid = {30525906}, url = {https://doi.org/10.1176/appi.ajp.2018.18050566} } @article{vanarendonk2023-36374264, author = {van Arendonk, J. and Neitzel, J. and Steketee, R. M. E. and van Assema, D. M. E. and Vrooman, H. A. and Segbers, M. and Ikram, M. A. and Vernooij, M. W.}, title = {{Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study}}, journal = {Brain : a journal of neurology}, year = {2023}, doi = {10.1093/brain/awac354}, pmid = {36374264}, url = {https://doi.org/10.1093/brain/awac354} } @article{reitz2008-18006863, author = {Reitz, C. and Bos, M. J. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Prestroke cognitive performance, incident stroke, and risk of dementia: the Rotterdam Study}}, journal = {Stroke}, year = {2008}, doi = {10.1161/strokeaha.107.490334}, pmid = {18006863}, url = {https://doi.org/10.1161/strokeaha.107.490334} } @article{hofe2025-40040336, author = {Hofe, Ilse vom and Stricker, Bruno H. Ch. and Ikram, Muhammad Aimen and Ikram, M. Kamran and Wolters, Frank J. and Ikram, M. Arfan}, title = {{Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk}}, journal = {Journal of the American Geriatrics Society}, year = {2025}, doi = {10.1111/jgs.19411}, pmid = {40040336}, url = {https://doi.org/10.1111/jgs.19411} } @article{denheijer2006-16389197, author = {den Heijer, T. and Geerlings, M. I. and Hoebeek, F. E. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people}}, journal = {Archives of general psychiatry}, year = {2006}, doi = {10.1001/archpsyc.63.1.57}, pmid = {16389197}, url = {https://doi.org/10.1001/archpsyc.63.1.57} } @article{toledo2017-28341160, author = {Toledo, J. B. and Arnold, M. and Kastenmüller, G. and Chang, R. and Baillie, R. A. and Han, X. and Thambisetty, M. and Tenenbaum, J. D. and others}, title = {{Metabolic network failures in Alzheimer's disease: A biochemical road map}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2017.01.020}, pmid = {28341160}, url = {https://doi.org/10.1016/j.jalz.2017.01.020} } @article{kalmijn1997-9392577, author = {Kalmijn, S. and Launer, L. J. and Ott, A. and Witteman, J. C. and Hofman, A. and Breteler, M. M.}, title = {{Dietary fat intake and the risk of incident dementia in the Rotterdam Study}}, journal = {Annals of neurology}, year = {1997}, doi = {10.1002/ana.410420514}, pmid = {9392577}, url = {https://doi.org/10.1002/ana.410420514} } @article{harhangi2000-10746597, author = {Harhangi, B. S. and de Rijk, M. C. and van Duijn, C. M. and Van Broeckhoven, C. and Hofman, A. and Breteler, M. M.}, title = {{APOE and the risk of PD with or without dementia in a population-based study}}, journal = {Neurology}, year = {2000}, doi = {10.1212/wnl.54.6.1272}, pmid = {10746597}, url = {https://doi.org/10.1212/wnl.54.6.1272} } @article{salas2001-11753273, author = {Salas, M. and In't Veld, B. A. and van der Linden, P. D. and Hofman, A. and Breteler, M. and Stricker, B. H.}, title = {{Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study}}, journal = {Clinical pharmacology and therapeutics}, year = {2001}, doi = {10.1067/mcp.2001.119812}, pmid = {11753273}, url = {https://doi.org/10.1067/mcp.2001.119812} } @article{charidimou2015-26115675, author = {Charidimou, A. and Linn, J. and Vernooij, M. W. and Opherk, C. and Akoudad, S. and Baron, J. C. and Greenberg, S. M. and Jäger, H. R. and others}, title = {{Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions}}, journal = {Brain : a journal of neurology}, year = {2015}, doi = {10.1093/brain/awv162}, pmid = {26115675}, url = {https://doi.org/10.1093/brain/awv162} } @article{mielke2022-35394117, author = {Mielke, M. M. and Aggarwal, N. T. and Vila-Castelar, C. and Agarwal, P. and Arenaza-Urquijo, E. M. and Brett, B. and Brugulat-Serrat, A. and DuBose, L. E. and others}, title = {{Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2022}, doi = {10.1002/alz.12662}, pmid = {35394117}, url = {https://doi.org/10.1002/alz.12662} } @article{frisoni2023-36895446, author = {Frisoni, G. B. and Altomare, D. and Ribaldi, F. and Villain, N. and Brayne, C. and Mukadam, N. and Abramowicz, M. and Barkhof, F. and others}, title = {{Dementia prevention in memory clinics: recommendations from the European task force for brain health services}}, journal = {The Lancet regional health. Europe}, year = {2023}, doi = {10.1016/j.lanepe.2022.100576}, pmid = {36895446}, url = {https://doi.org/10.1016/j.lanepe.2022.100576} } @article{zerr2009-19773352, author = {Zerr, I. and Kallenberg, K. and Summers, D. M. and Romero, C. and Taratuto, A. and Heinemann, U. and Breithaupt, M. and Varges, D. and others}, title = {{Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease}}, journal = {Brain : a journal of neurology}, year = {2009}, doi = {10.1093/brain/awp191}, pmid = {19773352}, url = {https://doi.org/10.1093/brain/awp191} } @article{mirza2016-27138970, author = {Mirza, S. S. and Wolters, F. J. and Swanson, S. A. and Koudstaal, P. J. and Hofman, A. and Tiemeier, H. and Ikram, M. A.}, title = {{10-year trajectories of depressive symptoms and risk of dementia: a population-based study}}, journal = {The lancet. Psychiatry}, year = {2016}, doi = {10.1016/s2215-0366(16)00097-3}, pmid = {27138970}, url = {https://doi.org/10.1016/s2215-0366(16)00097-3} } @article{kalmijn2000-11155096, author = {Kalmijn, S. and Mehta, K. M. and Pols, H. A. and Hofman, A. and Drexhage, H. A. and Breteler, M. M.}, title = {{Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study}}, journal = {Clinical endocrinology}, year = {2000}, doi = {10.1046/j.1365-2265.2000.01146.x}, pmid = {11155096}, url = {https://doi.org/10.1046/j.1365-2265.2000.01146.x} } @article{dekkers2019-31012815, author = {Dekkers, I. A. and Jansen, P. R. and Lamb, H. J.}, title = {{Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank Study}}, journal = {Radiology}, year = {2019}, doi = {10.1148/radiol.2019181012}, pmid = {31012815}, url = {https://doi.org/10.1148/radiol.2019181012} } @article{devore2009-19474131, author = {Devore, E. E. and Grodstein, F. and van Rooij, F. J. and Hofman, A. and Rosner, B. and Stampfer, M. J. and Witteman, J. C. and Breteler, M. M.}, title = {{Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk}}, journal = {The American journal of clinical nutrition}, year = {2009}, doi = {10.3945/ajcn.2008.27037}, pmid = {19474131}, url = {https://doi.org/10.3945/ajcn.2008.27037} } @article{stephan2020-32199121, author = {Stephan, B. C. M. and Pakpahan, E. and Siervo, M. and Licher, S. and Muniz-Terrera, G. and Mohan, D. and Acosta, D. and Rodriguez Pichardo, G. and others}, title = {{Prediction of dementia risk in low-income and middle-income countries (the 10/66 Study): an independent external validation of existing models}}, journal = {The Lancet. Global health}, year = {2020}, doi = {10.1016/s2214-109x(20)30062-0}, pmid = {32199121}, url = {https://doi.org/10.1016/s2214-109x(20)30062-0} } @article{vanderwillik2019-30927918, author = {van der Willik, K. D. and Fani, L. and Rizopoulos, D. and Licher, S. and Fest, J. and Schagen, S. B. and Ikram, M. K. and Ikram, M. A.}, title = {{Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study}}, journal = {Journal of neuroinflammation}, year = {2019}, doi = {10.1186/s12974-019-1454-z}, pmid = {30927918}, url = {https://doi.org/10.1186/s12974-019-1454-z} } @article{darweesh2017-28973176, author = {Darweesh, S. K. L. and Wolters, F. J. and Postuma, R. B. and Stricker, B. H. and Hofman, A. and Koudstaal, P. J. and Ikram, M. K. and Ikram, M. A.}, title = {{Association Between Poor Cognitive Functioning and Risk of Incident Parkinsonism: The Rotterdam Study}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.2248}, pmid = {28973176}, url = {https://doi.org/10.1001/jamaneurol.2017.2248} } @article{delau2006-16401729, author = {de Lau, L. M. and Koudstaal, P. J. and Hofman, A. and Breteler, M. M.}, title = {{Subjective complaints precede Parkinson disease: the rotterdam study}}, journal = {Archives of neurology}, year = {2006}, doi = {10.1001/archneur.63.3.noc50312}, pmid = {16401729}, url = {https://doi.org/10.1001/archneur.63.3.noc50312} } @article{kieboom2017-28931641, author = {Kieboom, B. C. T. and Licher, S. and Wolters, F. J. and Ikram, M. K. and Hoorn, E. J. and Zietse, R. and Stricker, B. H. and Ikram, M. A.}, title = {{Serum magnesium is associated with the risk of dementia}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004517}, pmid = {28931641}, url = {https://doi.org/10.1212/wnl.0000000000004517} } @article{hokahin2025-40866991, author = {Hok-A-Hin, Yanaika Sylvana and Vermunt, Lisa and Peeters, Carel F.W. and van der Ende, Emma Louise and de Boer, Sterre C.M. and Meeter, Lieke H. H. and De Houwer, Julie F. H. and Seelaar, Harro and others}, title = {{Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia}}, journal = {Molecular Neurodegeneration}, year = {2025}, doi = {10.1186/s13024-025-00882-5}, pmid = {40866991}, url = {https://doi.org/10.1186/s13024-025-00882-5} } @article{sogorbesteve2025-39908349, author = {Sogorb‐Esteve, Aitana and Weiner, Sophia and Simrén, Joel and Swift, Imogen J. and Bocchetta, Martina and Todd, Emily G. and Cash, David M. and Bouzigues, Arabella and others}, title = {{Proteomic analysis reveals distinct cerebrospinal fluid signatures across genetic frontotemporal dementia subtypes}}, journal = {Science Translational Medicine}, year = {2025}, doi = {10.1126/scitranslmed.adm9654}, pmid = {39908349}, url = {https://doi.org/10.1126/scitranslmed.adm9654} } @article{vanarendonk2024-37535203, author = {van Arendonk, J. and Wolters, F. J. and Neitzel, J. and Vinke, E. J. and Vernooij, M. W. and Ghanbari, M. and Ikram, M. A.}, title = {{Plasma neurofilament light chain in relation to 10-year change in cognition and neuroimaging markers: a population-based study}}, journal = {GeroScience}, year = {2024}, doi = {10.1007/s11357-023-00876-5}, pmid = {37535203}, url = {https://doi.org/10.1007/s11357-023-00876-5} } @article{hachinski2006-16917086, author = {Hachinski, V. and Iadecola, C. and Petersen, R. C. and Breteler, M. M. and Nyenhuis, D. L. and Black, S. E. and Powers, W. J. and DeCarli, C. and others}, title = {{National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards}}, journal = {Stroke}, year = {2006}, doi = {10.1161/01.str.0000237236.88823.47}, pmid = {16917086}, url = {https://doi.org/10.1161/01.str.0000237236.88823.47} } @article{denheijer2003-14595538, author = {den Heijer, T. and Vermeer, S. E. and van Dijk, E. J. and Prins, N. D. and Koudstaal, P. J. and Hofman, A. and Breteler, M. M.}, title = {{Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI}}, journal = {Diabetologia}, year = {2003}, doi = {10.1007/s00125-003-1235-0}, pmid = {14595538}, url = {https://doi.org/10.1007/s00125-003-1235-0} } @article{bolt2015-25693947, author = {Bolt, E. E. and Snijdewind, M. C. and Willems, D. L. and van der Heide, A. and Onwuteaka-Philipsen, B. D.}, title = {{Can physicians conceive of performing euthanasia in case of psychiatric disease, dementia or being tired of living?}}, journal = {Journal of medical ethics}, year = {2015}, doi = {10.1136/medethics-2014-102150}, pmid = {25693947}, url = {https://doi.org/10.1136/medethics-2014-102150} } @article{vernooij2019-30852630, author = {Vernooij, M. W. and Pizzini, F. B. and Schmidt, R. and Smits, M. and Yousry, T. A. and Bargallo, N. and Frisoni, G. B. and others}, title = {{Dementia imaging in clinical practice: a European-wide survey of 193 centres and conclusions by the ESNR working group}}, journal = {Neuroradiology}, year = {2019}, doi = {10.1007/s00234-019-02188-y}, pmid = {30852630}, url = {https://doi.org/10.1007/s00234-019-02188-y} } @article{dejong2011-21288987, author = {de Jong, F. J. and Schrijvers, E. M. and Ikram, M. K. and Koudstaal, P. J. and de Jong, P. T. and Hofman, A. and Vingerling, JR. and Breteler, M. M.}, title = {{Retinal vascular caliber and risk of dementia: the Rotterdam study}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e31820e7baa}, pmid = {21288987}, url = {https://doi.org/10.1212/wnl.0b013e31820e7baa} } @article{licher2019-30279211, author = {Licher, S. and Darweesh, S. K. L. and Wolters, F. J. and Fani, L. and Heshmatollah, A. and Mutlu, U. and Koudstaal, P. J. and Heeringa, J. and others}, title = {{Lifetime risk of common neurological diseases in the elderly population}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2019}, doi = {10.1136/jnnp-2018-318650}, pmid = {30279211}, url = {https://doi.org/10.1136/jnnp-2018-318650} } @article{schrijvers2012-22116812, author = {Schrijvers, E. M. and Schürmann, B. and Koudstaal, P. J. and van den Bussche, H. and Van Duijn, C. M. and Hentschel, F. and Heun, R. and Hofman, A. and others}, title = {{Genome-wide association study of vascular dementia}}, journal = {Stroke}, year = {2012}, doi = {10.1161/strokeaha.111.628768}, pmid = {22116812}, url = {https://doi.org/10.1161/strokeaha.111.628768} } @article{sleegers2006-16921174, author = {Sleegers, K. and Brouwers, N. and Gijselinck, I. and Theuns, J. and Goossens, D. and Wauters, J. and Del-Favero, J. and Cruts, M. and others}, title = {{APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy}}, journal = {Brain : a journal of neurology}, year = {2006}, doi = {10.1093/brain/awl203}, pmid = {16921174}, url = {https://doi.org/10.1093/brain/awl203} } @article{haller2018-29558307, author = {Haller, S. and Vernooij, M. W. and Kuijer, J. P. A. and Larsson, E. M. and Jäger, H. R. and Barkhof, F.}, title = {{Cerebral Microbleeds: Imaging and Clinical Significance}}, journal = {Radiology}, year = {2018}, doi = {10.1148/radiol.2018170803}, pmid = {29558307}, url = {https://doi.org/10.1148/radiol.2018170803} } @article{oomens2025-39939930, author = {Oomens, Julie Elisabeth and Moonen, Justine E. F. and Vos, Stephanie J. B. and Beran, Magdalena and Mateus, Pedro and De Deyn, Peter Paul and van der Flier, Wiesje M. and Geerlings, Mirjam I. and others}, title = {{Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts}}, journal = {BMC Neurology}, year = {2025}, doi = {10.1186/s12883-024-03995-4}, pmid = {39939930}, url = {https://doi.org/10.1186/s12883-024-03995-4} } @article{vandenberg2017-28624827, author = {van den Berg, Esther and Jiskoot, Lize Corrine and Grosveld, Mariëlle J.H. and Van Swieten, John Cornelis and Papma, Janne M.}, title = {{Qualitative Assessment of Verbal Fluency Performance in Frontotemporal Dementia}}, journal = {Dementia and Geriatric Cognitive Disorders}, year = {2017}, doi = {10.1159/000477538}, pmid = {28624827}, url = {https://doi.org/10.1159/000477538} } @article{wolters2019-31294622, author = {Wolters, F. J. and Ikram, M. A.}, title = {{Epidemiology of Vascular Dementia}}, journal = {Arteriosclerosis, thrombosis, and vascular biology}, year = {2019}, doi = {10.1161/atvbaha.119.311908}, pmid = {31294622}, url = {https://doi.org/10.1161/atvbaha.119.311908} } @article{seelaar2011-20971753, author = {Seelaar, H. and Rohrer, J. D. and Pijnenburg, Y. A. and Fox, N. C. and van Swieten, J. C.}, title = {{Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2011}, doi = {10.1136/jnnp.2010.212225}, pmid = {20971753}, url = {https://doi.org/10.1136/jnnp.2010.212225} } @article{wiese2023-37218539, author = {Wiese, L. A. K. and Gibson, A. and Guest, M. A. and Nelson, A. R. and Weaver, R. and Gupta, A. and Carmichael, O. and Lewis, J. P. and others}, title = {{Global rural health disparities in Alzheimer's disease and related dementias: State of the science}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.13104}, pmid = {37218539}, url = {https://doi.org/10.1002/alz.13104} } @article{kalia2015-25401511, author = {Kalia, L. V. and Lang, A. E. and Hazrati, L. N. and Fujioka, S. and Wszolek, Z. K. and Dickson, D. W. and Ross, O. A. and Van Deerlin, V. M. and others}, title = {{Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2014.2704}, pmid = {25401511}, url = {https://doi.org/10.1001/jamaneurol.2014.2704} } @article{rosso2003-12975285, author = {Rosso, S. M. and van Herpen, E. and Pijnenburg, Y. A. and Schoonenboom, N. S. and Scheltens, P. and Heutink, P. and van Swieten, J. C.}, title = {{Total tau and phosphorylated tau 181 levels in the cerebrospinal fluid of patients with frontotemporal dementia due to P301L and G272V tau mutations}}, journal = {Archives of neurology}, year = {2003}, doi = {10.1001/archneur.60.9.1209}, pmid = {12975285}, url = {https://doi.org/10.1001/archneur.60.9.1209} } @article{poels2007-17272780, author = {Poels, M. M. and van Oijen, M. and Mattace-Raso, F. U. and Hofman, A. and Koudstaal, P. J. and Witteman, J. C. and Breteler, M. M.}, title = {{Arterial stiffness, cognitive decline, and risk of dementia: the Rotterdam study}}, journal = {Stroke}, year = {2007}, doi = {10.1161/01.str.0000257998.33768.87}, pmid = {17272780}, url = {https://doi.org/10.1161/01.str.0000257998.33768.87} } @article{debruijn2013-23385659, author = {de Bruijn, R. F. and Schrijvers, E. M. and de Groot, K. A. and Witteman, J. C. and Hofman, A. and Franco, O. H. and Koudstaal, P. J. and Ikram, M. A.}, title = {{The association between physical activity and dementia in an elderly population: the Rotterdam Study}}, journal = {European journal of epidemiology}, year = {2013}, doi = {10.1007/s10654-013-9773-3}, pmid = {23385659}, url = {https://doi.org/10.1007/s10654-013-9773-3} } @article{decrom2022-35022067, author = {de Crom, T. O. E. and Mooldijk, S. S. and Ikram, M. K. and Ikram, M. A. and Voortman, T.}, title = {{MIND diet and the risk of dementia: a population-based study}}, journal = {Alzheimer's research \& therapy}, year = {2022}, doi = {10.1186/s13195-022-00957-1}, pmid = {35022067}, url = {https://doi.org/10.1186/s13195-022-00957-1} } @article{geerlings2003-12730994, author = {Geerlings, M. I. and Launer, L. J. and de Jong, F. H. and Ruitenberg, A. and Stijnen, T. and van Swieten, J. C. and Hofman, A. and Witteman, J. C. and others}, title = {{Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study}}, journal = {Annals of neurology}, year = {2003}, doi = {10.1002/ana.10521}, pmid = {12730994}, url = {https://doi.org/10.1002/ana.10521} } @article{vanderwillik2021-32750110, author = {van der Willik, K. D. and Licher, S. and Vinke, E. J. and Knol, M. J. and Darweesh, S. K. L. and van der Geest, J. N. and Schagen, S. B. and Ikram, M. K. and others}, title = {{Trajectories of Cognitive and Motor Function Between Ages 45 and 90 Years: A Population-Based Study}}, journal = {The journals of gerontology. Series A, Biological sciences and medical sciences}, year = {2021}, doi = {10.1093/gerona/glaa187}, pmid = {32750110}, url = {https://doi.org/10.1093/gerona/glaa187} } @article{ott1999-10025813, author = {Ott, A. and van Rossum, C. T. and van Harskamp, F. and van de Mheen, H. and Hofman, A. and Breteler, M. M.}, title = {{Education and the incidence of dementia in a large population-based study: the Rotterdam Study}}, journal = {Neurology}, year = {1999}, doi = {10.1212/wnl.52.3.663}, pmid = {10025813}, url = {https://doi.org/10.1212/wnl.52.3.663} } @article{wolters2019-30299452, author = {Wolters, F. J. and Tinga, L. M. and Dhana, K. and Koudstaal, P. J. and Hofman, A. and Bos, D. and Franco, O. H. and Ikram, M. A.}, title = {{Life Expectancy With and Without Dementia: A Population-Based Study of Dementia Burden and Preventive Potential}}, journal = {American journal of epidemiology}, year = {2019}, doi = {10.1093/aje/kwy234}, pmid = {30299452}, url = {https://doi.org/10.1093/aje/kwy234} } @article{direk2012-22381733, author = {Direk, N. and Koudstaal, P. J. and Hofman, A. and Ikram, M. A. and Hoogendijk, W. J. and Tiemeier, H.}, title = {{Cerebral hemodynamics and incident depression: the Rotterdam Study}}, journal = {Biological psychiatry}, year = {2012}, doi = {10.1016/j.biopsych.2012.01.019}, pmid = {22381733}, url = {https://doi.org/10.1016/j.biopsych.2012.01.019} } @article{urwin2010-20490813, author = {Urwin, H. and Josephs, K. A. and Rohrer, J. D. and Mackenzie, I. R. and Neumann, M. and Authier, A. and Seelaar, H. and Van Swieten, J. C. and others}, title = {{FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration}}, journal = {Acta neuropathologica}, year = {2010}, doi = {10.1007/s00401-010-0698-6}, pmid = {20490813}, url = {https://doi.org/10.1007/s00401-010-0698-6} } @article{nielsen2025-40545610, author = {Nielsen, T. Rune and Jørgensen, Kasper and Delgado‐Álvarez, Alfonso and Franzen, Sanne and Lozano-Ruiz, Álvaro and Özden, Maria and Palisson, Juliette and Mukadam, Naaheed and others}, title = {{Comparison of the diagnostic accuracy of five cross-cultural cognitive screening instruments for dementia and mild cognitive impairment in a multicultural memory clinic sample}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251351037}, pmid = {40545610}, url = {https://doi.org/10.1177/13872877251351037} } @article{vigneswaran2026-42593792, author = {Vigneswaran, S. and Verberk, I. M. W. and Boonkamp, L. and In 't Veld, L. and Koel-Simmelink, M. J. A. and Antwi-Berko, D. and van Unen, L. and Rousset, R. and Claessen, T. and Zwan, M. D. and Ossenkoppele, R. and Wilson, D. and others}, title = {{Plasma Alzheimer Biomarkers and Diagnostic Decision-Making in Memory Clinics}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.28864}, pmid = {42593792}, url = {https://doi.org/10.1001/jamanetworkopen.2026.28864} } @article{intveld2001-11378246, author = {in't Veld, B. A. and Ruitenberg, A. and Hofman, A. and Stricker, B. H. and Breteler, M. M.}, title = {{Antihypertensive drugs and incidence of dementia: the Rotterdam Study}}, journal = {Neurobiology of aging}, year = {2001}, doi = {10.1016/s0197-4580(00)00241-4}, pmid = {11378246}, url = {https://doi.org/10.1016/s0197-4580(00)00241-4} } @article{fani2020-31839608, author = {Fani, L. and Hilal, S. and Sedaghat, S. and Broer, L. and Licher, S. and Arp, P. P. and van Meurs, J. B. J. and Ikram, M. K. and others}, title = {{Telomere Length and the Risk of Alzheimer's Disease: The Rotterdam Study}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2020}, doi = {10.3233/jad-190759}, pmid = {31839608}, url = {https://doi.org/10.3233/jad-190759} } @article{freakpoli2017-28673434, author = {Freak-Poli, R. and Kirkman, M. and De Castro Lima, G. and Direk, N. and Franco, O. H. and Tiemeier, H.}, title = {{Sexual Activity and Physical Tenderness in Older Adults: Cross-Sectional Prevalence and Associated Characteristics}}, journal = {The journal of sexual medicine}, year = {2017}, doi = {10.1016/j.jsxm.2017.05.010}, pmid = {28673434}, url = {https://doi.org/10.1016/j.jsxm.2017.05.010} } @article{murphy2021-33888766, author = {Murphy, M. J. and Fani, L. and Ikram, M. K. and Ghanbari, M. and Ikram, M. A.}, title = {{Herpes simplex virus 1 and the risk of dementia: a population-based study}}, journal = {Scientific reports}, year = {2021}, doi = {10.1038/s41598-021-87963-9}, pmid = {33888766}, url = {https://doi.org/10.1038/s41598-021-87963-9} } @article{vanduijn1994-8075646, author = {van Duijn, C. M. and de Knijff, P. and Cruts, M. and Wehnert, A. and Havekes, L. M. and Hofman, A. and Van Broeckhoven, C.}, title = {{Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease}}, journal = {Nature genetics}, year = {1994}, doi = {10.1038/ng0594-74}, pmid = {8075646}, url = {https://doi.org/10.1038/ng0594-74} } @article{rosbergen2025-40629712, author = {Rosbergen, Mathijs T. and van der Veere, Pieter J. and Claus, Jacqueline Josephine and Evans, Tavia E. and Venkatraghavan, Vikram and Barkhof, Frederik and van Harten, Argonde C. and Ikram, M. Arfan and others}, title = {{Subcortical gray matter volumes and 5‐year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi‐cohort analysis}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70413}, pmid = {40629712}, url = {https://doi.org/10.1002/alz.70413} } @article{liu2025-40277074, author = {Liu, Xulin and de Boer, Sterre C.M. and Cortez, Kasey and Poos, Jackie M. and Illán‐Gala, Ignacio and Heuer, Hilary W. and Forsberg, Leah K. and Casaletto, Kaitlin Blackstone and others}, title = {{Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.14608}, pmid = {40277074}, url = {https://doi.org/10.1002/alz.14608} } @article{kan2025-39761997, author = {Kan, Cheuk Ni and Coenen, Mirthe and Xu, Xin Yi and Hilal, Saima and Barkhof, Frederik and Benke, Thomas and Dal‐Bianco, Peter and DeCarli, Charles S and others}, title = {{Tract-specific white matter hyperintensities and neuropsychiatric syndromes: a multicentre memory clinic study}}, journal = {Journal of Neurology Neurosurgery \& Psychiatry}, year = {2025}, doi = {10.1136/jnnp-2024-334264}, pmid = {39761997}, url = {https://doi.org/10.1136/jnnp-2024-334264} } @article{caro2025-41266628, author = {Caro, Ilana and Western, Daniel and Namba, Shinichi and Sun, Na and Kawaguchi, Shuji and He, Yunye and Fujita, Masashi and Roshchupkin, Gennady V. and others}, title = {{Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease}}, journal = {Nature Aging}, year = {2025}, doi = {10.1038/s43587-025-01006-w}, pmid = {41266628}, url = {https://doi.org/10.1038/s43587-025-01006-w} } @article{heshmatollah2022-35232820, author = {Heshmatollah, A. and Fani, L. and Koudstaal, P. J. and Ghanbari, M. and Ikram, M. A. and Ikram, M. K.}, title = {{Plasma β-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200004}, pmid = {35232820}, url = {https://doi.org/10.1212/wnl.0000000000200004} } @article{birkenbihl2020-32843907, author = {Birkenbihl, C. and Emon, M. A. and Vrooman, H. and Westwood, S. and Lovestone, S. and {AddNeuroMed Consortium} and Hofmann-Apitius, M. and Fröhlich, H. and others}, title = {{Differences in cohort study data affect external validation of artificial intelligence models for predictive diagnostics of dementia - lessons for translation into clinical practice}}, journal = {The EPMA journal}, year = {2020}, doi = {10.1007/s13167-020-00216-z}, pmid = {32843907}, url = {https://doi.org/10.1007/s13167-020-00216-z} } @article{vandamme2008-18378771, author = {Van Damme, P. and Van Hoecke, A. and Lambrechts, D. and Vanacker, P. and Bogaert, E. and van Swieten, J. and Carmeliet, P. and Van Den Bosch, L. and others}, title = {{Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival}}, journal = {The Journal of cell biology}, year = {2008}, doi = {10.1083/jcb.200712039}, pmid = {18378771}, url = {https://doi.org/10.1083/jcb.200712039} } @article{ahmad2024-39080778, author = {Ahmad, S. and Yang, W. and Orellana, A. and Frölich, L. and de Rojas, I. and Cano, A. and Boada, M. and Hernández, I. and others}, title = {{Association of oxidative stress and inflammatory metabolites with Alzheimer's disease cerebrospinal fluid biomarkers in mild cognitive impairment}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01542-4}, pmid = {39080778}, url = {https://doi.org/10.1186/s13195-024-01542-4} } @article{portegies2016-27418596, author = {Portegies, M. L. and Wolters, F. J. and Hofman, A. and Ikram, M. K. and Koudstaal, P. J. and Ikram, M. A.}, title = {{Prestroke Vascular Pathology and the Risk of Recurrent Stroke and Poststroke Dementia}}, journal = {Stroke}, year = {2016}, doi = {10.1161/strokeaha.116.014094}, pmid = {27418596}, url = {https://doi.org/10.1161/strokeaha.116.014094} } @article{hilal2018-29960604, author = {Hilal, S. and Wolters, F. J. and Verbeek, M. M. and Vanderstichele, H. and Ikram, M. K. and Stoops, E. and Ikram, M. A. and Vernooij, M. W.}, title = {{Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study}}, journal = {Alzheimer's research \& therapy}, year = {2018}, doi = {10.1186/s13195-018-0395-6}, pmid = {29960604}, url = {https://doi.org/10.1186/s13195-018-0395-6} } @article{najoua2025-39947158, author = {Najoua, Lazaar and Van Beek Sabine, E. and Rirash Awaale, F. and Papma Janne, M. and Jaime, Perales-Puchalt and Shaw Ashley, R. and Vidoni Eric, D. and Sanne, Franzen}, title = {{Diversity in United States Dementia Prevention Trials: An Updated Systematic Review of Eligibility Criteria and Recruitment Strategies}}, journal = {Dementia and geriatric cognitive disorders}, year = {2025}, doi = {10.1159/000543905}, pmid = {39947158}, url = {https://doi.org/10.1159/000543905} } @article{hofman2007-17955331, author = {Hofman, Albert and Breteler, Monique M.B. and van Duijn, Cornelia M. and Krestin, Gabriel Paul and Pols, Huibert A. P. and Stricker, Bruno H. Ch. and Tiemeier, Henning W. and Uitterlinden, André Gerardus and Vingerling, Johannes R. and Witteman, Jacqueline C.M.}, title = {{The Rotterdam Study: objectives and design update}}, journal = {European Journal of Epidemiology}, year = {2007}, doi = {10.1007/s10654-007-9199-x}, pmid = {17955331}, url = {https://doi.org/10.1007/s10654-007-9199-x} } @article{holstege2017-28537274, author = {Holstege, H. and van der Lee, S. J. and Hulsman, M. and Wong, T. H. and van Rooij, J. G. and Weiss, M. and Louwersheimer, E. and Wolters, F. J. and others}, title = {{Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy}}, journal = {European journal of human genetics : EJHG}, year = {2017}, doi = {10.1038/ejhg.2017.87}, pmid = {28537274}, url = {https://doi.org/10.1038/ejhg.2017.87} } @article{denheijer2005-15668423, author = {den Heijer, T. and Launer, L. J. and Prins, N. D. and van Dijk, E. J. and Vermeer, S. E. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe}}, journal = {Neurology}, year = {2005}, doi = {10.1212/01.wnl.0000149641.55751.2e}, pmid = {15668423}, url = {https://doi.org/10.1212/01.wnl.0000149641.55751.2e} } @article{breteler1994-8202966, author = {Breteler, M. M. and van Amerongen, N. M. and van Swieten, J. C. and Claus, J. J. and Grobbee, D. E. and van Gijn, J. and Hofman, A. and van Harskamp, F.}, title = {{Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study}}, journal = {Stroke}, year = {1994}, doi = {10.1161/01.str.25.6.1109}, pmid = {8202966}, url = {https://doi.org/10.1161/01.str.25.6.1109} } @article{bos2007-18159057, author = {Bos, M. J. and van Rijn, M. J. and Witteman, J. C. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Incidence and prognosis of transient neurological attacks}}, journal = {JAMA}, year = {2007}, doi = {10.1001/jama.298.24.2877}, pmid = {18159057}, url = {https://doi.org/10.1001/jama.298.24.2877} } @article{debruijn2014-24825566, author = {de Bruijn, R. F. and Akoudad, S. and Cremers, L. G. and Hofman, A. and Niessen, W. J. and van der Lugt, A. and Koudstaal, P. J. and Vernooij, M. W. and others}, title = {{Determinants, MRI correlates, and prognosis of mild cognitive impairment: the Rotterdam Study}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2014}, doi = {10.3233/jad-132558}, pmid = {24825566}, url = {https://doi.org/10.3233/jad-132558} } @article{darweesh2016-27188952, author = {Darweesh, S. K. and Koudstaal, P. J. and Stricker, B. H. and Hofman, A. and Ikram, M. A.}, title = {{Trends in the Incidence of Parkinson Disease in the General Population: The Rotterdam Study}}, journal = {American journal of epidemiology}, year = {2016}, doi = {10.1093/aje/kwv271}, pmid = {27188952}, url = {https://doi.org/10.1093/aje/kwv271} } @article{quadri2018-29887161, author = {Quadri, M. and Mandemakers, W. and Grochowska, M. M. and Masius, R. and Geut, H. and Fabrizio, E. and Breedveld, G. J. and Kuipers, D. and others}, title = {{LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(18)30179-0}, pmid = {29887161}, url = {https://doi.org/10.1016/s1474-4422(18)30179-0} } @article{moller2016-26653846, author = {Möller, C. and Pijnenburg, Y. A. and van der Flier, W. M. and Versteeg, A. and Tijms, B. and de Munck, J. C. and Hafkemeijer, A. and Rombouts, S. A. and others}, title = {{Alzheimer Disease and Behavioral Variant Frontotemporal Dementia: Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis}}, journal = {Radiology}, year = {2016}, doi = {10.1148/radiol.2015150220}, pmid = {26653846}, url = {https://doi.org/10.1148/radiol.2015150220} } @article{giannini2021-33622418, author = {Giannini, L. A. A. and Peterson, C. and Ohm, D. and Xie, S. X. and McMillan, C. T. and Raskovsky, K. and Massimo, L. and Suh, E. and others}, title = {{Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology}}, journal = {Acta neuropathologica communications}, year = {2021}, doi = {10.1186/s40478-021-01129-2}, pmid = {33622418}, url = {https://doi.org/10.1186/s40478-021-01129-2} } @article{liu2007-17564960, author = {Liu, F. and Arias-Vásquez, A. and Sleegers, K. and Aulchenko, Y. S. and Kayser, M. and Sanchez-Juan, P. and Feng, B. J. and Bertoli-Avella, A. M. and others}, title = {{A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population}}, journal = {American journal of human genetics}, year = {2007}, doi = {10.1086/518720}, pmid = {17564960}, url = {https://doi.org/10.1086/518720} } @article{hoogendam2014-24553905, author = {Hoogendam, Y. Y. and Hofman, A. and van der Geest, J. N. and van der Lugt, A. and Ikram, M. A.}, title = {{Patterns of cognitive function in aging: the Rotterdam Study}}, journal = {European journal of epidemiology}, year = {2014}, doi = {10.1007/s10654-014-9885-4}, pmid = {24553905}, url = {https://doi.org/10.1007/s10654-014-9885-4} } @article{bos2012-22537801, author = {Bos, D. and Vernooij, M. W. and Elias-Smale, S. E. and Verhaaren, B. F. and Vrooman, H. A. and Hofman, A. and Niessen, W. J. and Witteman, J. C. and others}, title = {{Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2012}, doi = {10.1016/j.jalz.2012.01.008}, pmid = {22537801}, url = {https://doi.org/10.1016/j.jalz.2012.01.008} } @article{yilmaz2018-30571403, author = {Yilmaz, P. and Ikram, M. K. and Niessen, W. J. and Ikram, M. A. and Vernooij, M. W.}, title = {{Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death}}, journal = {Stroke}, year = {2018}, doi = {10.1161/strokeaha.118.022485}, pmid = {30571403}, url = {https://doi.org/10.1161/strokeaha.118.022485} } @article{marquesvidal2025-40504596, author = {Marques-Vidal, Pedro Manuel and Tsampasian, Vasiliki and Cassidy, Aedín and Biondi‐Zoccai, Giuseppe and Chrysohoou, Christina A. and Koskinas, Konstantinos C. and Verschuren, W. M. Monique and Czapla, Michał and others}, title = {{Diet and nutrition in cardiovascular disease prevention: a scientific statement of the European Association of Preventive Cardiology and the Association of Cardiovascular Nursing \& Allied Professions of the European Society of Cardiology}}, journal = {European Journal of Preventive Cardiology}, year = {2025}, doi = {10.1093/eurjpc/zwaf310}, pmid = {40504596}, url = {https://doi.org/10.1093/eurjpc/zwaf310} } @article{liu2025-40605462, author = {Liu, Ella and Jones, Sherri Lee and Light, Victoria A. and Teunissen, Charlotte Elisabeth and Bouzigues, Arabella and Russell, Lucy Louise and Foster, Phoebe H. and Ferry‐Bolder, Eve and others}, title = {{Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251352103}, pmid = {40605462}, url = {https://doi.org/10.1177/13872877251352103} } @article{vandersteen2025-40032035, author = {van der Steen, Jenny Theodora and Van den Block, Lieve and Nakanishi, Miharu and Dening, Karen Harrison and Parker, Deborah and Larkin, Philip Joseph and Di Giulio, Paola and der Schmitten, Jürgen in and others}, title = {{Optimizing Advance Care Planning in Dementia: Recommendations From a 33-Country Delphi Study}}, journal = {Journal of Pain and Symptom Management}, year = {2025}, doi = {10.1016/j.jpainsymman.2025.02.471}, pmid = {40032035}, url = {https://doi.org/10.1016/j.jpainsymman.2025.02.471} } @article{ali2025-40259973, author = {Ali, Amira Mohammed and AL-Dossary, Saeed Abdullah and Laranjeira, Carlos and Selim, Abeer and Hallit, Souheil R. and Alkhamees, Abdulmajeed A. and Aljubilah, Aljawharah Fahad and Aljaberi, Musheer Abdulwahid Abdo and others}, title = {{Loneliness among dementia caregivers: evaluation of the psychometric properties and cutoff score of the Three-item UCLA Loneliness Scale}}, journal = {Frontiers in Psychiatry}, year = {2025}, doi = {10.3389/fpsyt.2025.1526569}, pmid = {40259973}, url = {https://doi.org/10.3389/fpsyt.2025.1526569} } @article{vokali2025-41136425, author = {Vokali, Efthymia and Chevalier, Elodie and Dreyfus, Nicolas and Charmey, Dorian and Melly, Tania and Kocher, Jacqueline and Ratnam, Monisha and Serra, Andreia M. and others}, title = {{Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology}}, journal = {Nature Communications}, year = {2025}, doi = {10.1038/s41467-025-64540-6}, pmid = {41136425}, url = {https://doi.org/10.1038/s41467-025-64540-6} } @article{schoonenboom2004-15136685, author = {Schoonenboom, N. S. and Pijnenburg, Y. A. and Mulder, C. and Rosso, S. M. and Van Elk, E. J. and Van Kamp, G. J. and Van Swieten, J. C. and Scheltens, P.}, title = {{Amyloid beta(1-42) and phosphorylated tau in CSF as markers for early-onset Alzheimer disease}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000123249.58898.e0}, pmid = {15136685}, url = {https://doi.org/10.1212/01.wnl.0000123249.58898.e0} } @article{derijk1997-9193212, author = {de Rijk, M. C. and Breteler, M. M. and den Breeijen, J. H. and Launer, L. J. and Grobbee, D. E. and van der Meché, F. G. and Hofman, A.}, title = {{Dietary antioxidants and Parkinson disease. The Rotterdam Study}}, journal = {Archives of neurology}, year = {1997}, doi = {10.1001/archneur.1997.00550180070015}, pmid = {9193212}, url = {https://doi.org/10.1001/archneur.1997.00550180070015} } @article{camposobando2018-29766437, author = {Campos-Obando, N. and Lahousse, L. and Brusselle, G. and Stricker, B. H. and Hofman, A. and Franco, O. H. and Uitterlinden, A. G. and Zillikens, M. C.}, title = {{Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men}}, journal = {European journal of epidemiology}, year = {2018}, doi = {10.1007/s10654-018-0407-7}, pmid = {29766437}, url = {https://doi.org/10.1007/s10654-018-0407-7} } @article{soltaninejad2025-41057914, author = {Soltaninejad, Mahdie and Dadar, Mahsa and Collins, D. Louis and Rajabli, Reza and Venkatraghavan, Vikram and Bouzigues, Arabella and Russell, Lucy Louise and Foster, Phoebe H. and others}, title = {{White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70695}, pmid = {41057914}, url = {https://doi.org/10.1002/alz.70695} } @article{reus2025-40214138, author = {Reus, Lianne Maria and Willemse, Sean W. and de Boer, Sterre C.M. and De Houwer, Julie and Hartog, Willem Lucas and Mol, Merel O. and van Rooij, Jeroen and Tesi, Niccoló and others}, title = {{UNC13A Polymorphism Influences Survival in Patients with Frontotemporal Dementia}}, journal = {Annals of Neurology}, year = {2025}, doi = {10.1002/ana.27245}, pmid = {40214138}, url = {https://doi.org/10.1002/ana.27245} } @article{bron2021-34118592, author = {Bron, E. E. and Klein, S. and Papma, J. M. and Jiskoot, L. C. and Venkatraghavan, V. and Linders, J. and Aalten, P. and De Deyn, P. P. and others}, title = {{Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease}}, journal = {NeuroImage. Clinical}, year = {2021}, doi = {10.1016/j.nicl.2021.102712}, pmid = {34118592}, url = {https://doi.org/10.1016/j.nicl.2021.102712} } @article{theuns2006-16685645, author = {Theuns, J. and Brouwers, N. and Engelborghs, S. and Sleegers, K. and Bogaerts, V. and Corsmit, E. and De Pooter, T. and van Duijn, C. M. and others}, title = {{Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease}}, journal = {American journal of human genetics}, year = {2006}, doi = {10.1086/504044}, pmid = {16685645}, url = {https://doi.org/10.1086/504044} } @article{mirza2014-24530024, author = {Mirza, S. S. and de Bruijn, R. F. and Direk, N. and Hofman, A. and Koudstaal, P. J. and Ikram, M. A. and Tiemeier, H.}, title = {{Depressive symptoms predict incident dementia during short- but not long-term follow-up period}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2014}, doi = {10.1016/j.jalz.2013.10.006}, pmid = {24530024}, url = {https://doi.org/10.1016/j.jalz.2013.10.006} } @article{debruijn2014-24745561, author = {de Bruijn, R. F. and Direk, N. and Mirza, S. S. and Hofman, A. and Koudstaal, P. J. and Tiemeier, H. and Ikram, M. A.}, title = {{Anxiety is not associated with the risk of dementia or cognitive decline: the Rotterdam Study}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2014}, doi = {10.1016/j.jagp.2014.03.001}, pmid = {24745561}, url = {https://doi.org/10.1016/j.jagp.2014.03.001} } @article{denheijer2004-15447910, author = {den Heijer, T. and Vermeer, S. E. and van Dijk, E. J. and Prins, N. D. and Koudstaal, P. J. and van Duijn, C. M. and Hofman, A. and Breteler, M. M.}, title = {{Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia}}, journal = {The American journal of clinical nutrition}, year = {2004}, doi = {10.1093/ajcn/80.4.992}, pmid = {15447910}, url = {https://doi.org/10.1093/ajcn/80.4.992} } @article{heutink1997-9029063, author = {Heutink, P. and Stevens, M. and Rizzu, P. and Bakker, E. and Kros, J. M. and Tibben, A. and Niermeijer, M. F. and van Duijn, C. M. and others}, title = {{Hereditary frontotemporal dementia is linked to chromosome 17q21-q22: a genetic and clinicopathological study of three Dutch families}}, journal = {Annals of neurology}, year = {1997}, doi = {10.1002/ana.410410205}, pmid = {9029063}, url = {https://doi.org/10.1002/ana.410410205} } @article{verlinden2016-26362597, author = {Verlinden, V. J. A. and van der Geest, J. N. and de Bruijn, R. F. A. G. and Hofman, A. and Koudstaal, P. J. and Ikram, M. A.}, title = {{Trajectories of decline in cognition and daily functioning in preclinical dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2016}, doi = {10.1016/j.jalz.2015.08.001}, pmid = {26362597}, url = {https://doi.org/10.1016/j.jalz.2015.08.001} } @article{mirza2016-25918047, author = {Mirza, S. S. and de Bruijn, R. F. and Koudstaal, P. J. and van den Meiracker, A. H. and Franco, O. H. and Hofman, A. and Tiemeier, H. and Ikram, M. A.}, title = {{The N-terminal pro B-type natriuretic peptide, and risk of dementia and cognitive decline: a 10-year follow-up study in the general population}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2016}, doi = {10.1136/jnnp-2014-309968}, pmid = {25918047}, url = {https://doi.org/10.1136/jnnp-2014-309968} } @article{walsh2026-42048404, author = {Walsh, Sebastian and Röhr, Susanne and Migeot, Joaquín and Bodryzlova, Yuliya and Ma’u, Etuini and Salemme, Simone and Marshall, Charles R. and Daly, Timothy P and others}, title = {{The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR)}}, journal = {PLoS Medicine}, year = {2026}, doi = {10.1371/journal.pmed.1005059}, pmid = {42048404}, url = {https://doi.org/10.1371/journal.pmed.1005059} } @article{claus2025-39956960, author = {Claus, Jacqueline Josephine and Rosbergen, Mathijs T. and Roshchupkin, Gennady V. and Ikram, M. Arfan and Vernooij, Meike Willemijn and Wolters, Frank J.}, title = {{Validation of a novel neuroimaging signature for dementia and clinical Alzheimer's disease in the population-based Rotterdam study}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251315044}, pmid = {39956960}, url = {https://doi.org/10.1177/13872877251315044} } @article{hofman1991-1833235, author = {Hofman, Albert and Grobbee, Diederick E. and de Jong, Paulus T.V.M. and Van Den Ouweland, Frank A}, title = {{Determinants of disease and disability in the elderly: The Rotterdam elderly study}}, journal = {European Journal of Epidemiology}, year = {1991}, doi = {10.1007/bf00145007}, pmid = {1833235}, url = {https://doi.org/10.1007/bf00145007} } @article{bis2020-30108311, author = {Bis, J. C. and Jian, X. and Kunkle, B. W. and Chen, Y. and Hamilton-Nelson, K. L. and Bush, W. S. and Salerno, W. J. and Lancour, D. and others}, title = {{Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation}}, journal = {Molecular psychiatry}, year = {2020}, doi = {10.1038/s41380-018-0112-7}, pmid = {30108311}, url = {https://doi.org/10.1038/s41380-018-0112-7} } @article{smedinga2021-32809153, author = {Smedinga, M. and Darweesh, S. K. L. and Bloem, B. R. and Post, B. and Richard, E.}, title = {{Towards early disease modification of Parkinson's disease: a review of lessons learned in the Alzheimer field}}, journal = {Journal of neurology}, year = {2021}, doi = {10.1007/s00415-020-10162-5}, pmid = {32809153}, url = {https://doi.org/10.1007/s00415-020-10162-5} } @article{sorop2017-28482008, author = {Sorop, O. and Olver, T. D. and van de Wouw, J. and Heinonen, I. and van Duin, R. W. and Duncker, D. J. and Merkus, D.}, title = {{The microcirculation: a key player in obesity-associated cardiovascular disease}}, journal = {Cardiovascular research}, year = {2017}, doi = {10.1093/cvr/cvx093}, pmid = {28482008}, url = {https://doi.org/10.1093/cvr/cvx093} } @article{valstar2008-18392742, author = {Valstar, M. J. and Ruijter, G. J. and van Diggelen, O. P. and Poorthuis, B. J. and Wijburg, F. A.}, title = {{Sanfilippo syndrome: a mini-review}}, journal = {Journal of inherited metabolic disease}, year = {2008}, doi = {10.1007/s10545-008-0838-5}, pmid = {18392742}, url = {https://doi.org/10.1007/s10545-008-0838-5} } @article{devugt2006-16679763, author = {de Vugt, M. E. and Riedijk, SR. and Aalten, P. and Tibben, A. and van Swieten, J. C. and Verhey, F. R.}, title = {{Impact of behavioural problems on spousal caregivers: a comparison between Alzheimer's disease and frontotemporal dementia}}, journal = {Dementia and geriatric cognitive disorders}, year = {2006}, doi = {10.1159/000093102}, pmid = {16679763}, url = {https://doi.org/10.1159/000093102} } @article{rosso2001-11571213, author = {Rosso, S. M. and Kamphorst, W. and de Graaf, B. and Willemsen, R. and Ravid, R. and Niermeijer, M. F. and Spillantini, M. G. and Heutink, P. and others}, title = {{Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22}}, journal = {Brain : a journal of neurology}, year = {2001}, doi = {10.1093/brain/124.10.1948}, pmid = {11571213}, url = {https://doi.org/10.1093/brain/124.10.1948} } @article{zuurbier2015-26206535, author = {Zuurbier, L. A. and Ikram, M. A. and Luik, A. I. and Hofman, A. and Van Someren, E. J. and Vernooij, M. W. and Tiemeier, H.}, title = {{Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study}}, journal = {European journal of neurology}, year = {2015}, doi = {10.1111/ene.12775}, pmid = {26206535}, url = {https://doi.org/10.1111/ene.12775} } @article{rajicic2026-41789476, author = {Rajicic, Ana and Mol, Merel O. and Melhem, Shamiram and Kisic, Helena and Van Swieten, John Cornelis and Seelaar, Harro and van Rooij, Jeroen}, title = {{Transcriptomic signature of frontotemporal lobar degeneration with TDP-43 type C pathology}}, journal = {Brain}, year = {2026}, doi = {10.1093/brain/awag085}, pmid = {41789476}, url = {https://doi.org/10.1093/brain/awag085} } @article{catindig2012-22877510, author = {Catindig, J. A. and Venketasubramanian, N. and Ikram, M. K. and Chen, C.}, title = {{Epidemiology of dementia in Asia: insights on prevalence, trends and novel risk factors}}, journal = {Journal of the neurological sciences}, year = {2012}, doi = {10.1016/j.jns.2012.07.023}, pmid = {22877510}, url = {https://doi.org/10.1016/j.jns.2012.07.023} } @article{piccirillo2008-18375141, author = {Piccirillo, J. F. and Vlahiotis, A. and Barrett, L. B. and Flood, K. L. and Spitznagel, E. L. and Steyerberg, E. W.}, title = {{The changing prevalence of comorbidity across the age spectrum}}, journal = {Critical reviews in oncology/hematology}, year = {2008}, doi = {10.1016/j.critrevonc.2008.01.013}, pmid = {18375141}, url = {https://doi.org/10.1016/j.critrevonc.2008.01.013} } @article{adams2015-25916564, author = {Adams, H. H. and de Bruijn, R. F. and Hofman, A. and Uitterlinden, A. G. and van Duijn, C. M. and Vernooij, M. W. and Koudstaal, P. J. and Ikram, M. A.}, title = {{Genetic risk of neurodegenerative diseases is associated with mild cognitive impairment and conversion to dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2014.12.008}, pmid = {25916564}, url = {https://doi.org/10.1016/j.jalz.2014.12.008} } @article{cerami2025-40365933, author = {Cerami, Chiara and Boccardi, Marina and Meli, Claudia and Panzavolta, Andrea and Funghi, Giulia and Festari, Cristina and Cappa, Stefano Francesco and Chatzikostopoulos, Thanos and others}, title = {{Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders}}, journal = {Journal of Neuropsychology}, year = {2025}, doi = {10.1111/jnp.12431}, pmid = {40365933}, url = {https://doi.org/10.1111/jnp.12431} } @article{bouzigues2025-40673371, author = {Bouzigues, Arabella and Le Du, Vincent and Joulot, Matthieu and Peysson, Ninon and Houot, Marion and Béranger, Benoît and Russell, Lucy Louise and Foster, Phoebe H. and others}, title = {{Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70367}, pmid = {40673371}, url = {https://doi.org/10.1002/alz.70367} } @article{graafland2026-41697408, author = {Graafland, Charlotte H and Seelaar, Harro and Panman, Jessica L. and Van Swieten, John Cornelis and Bunnik, Eline Maria and Kaat, Laura Donker}, title = {{Reasons for and against presymptomatic genetic testing in frontotemporal dementia: a qualitative study}}, journal = {Human Genetics}, year = {2026}, doi = {10.1007/s00439-025-02795-1}, pmid = {41697408}, url = {https://doi.org/10.1007/s00439-025-02795-1} } @article{caroppo2016-27280171, author = {Caroppo, P. and Camuzat, A. and Guillot-Noel, L. and Thomas-Antérion, C. and Couratier, P. and Wong, T. H. and Teichmann, M. and Golfier, V. and others}, title = {{Defining the spectrum of frontotemporal dementias associated with TARDBP mutations}}, journal = {Neurology. Genetics}, year = {2016}, doi = {10.1212/nxg.0000000000000080}, pmid = {27280171}, url = {https://doi.org/10.1212/nxg.0000000000000080} } @article{penatauber2026-42548036, author = {Peña‐Tauber, Andrés and Arriaza, Ricardo Hernández and Reil, Dylan and Muntaner, Manon and Park, Junyoung and Grenier‐Boley, Benjamin and Hulsman, Marc and Amouyel, Philippe and others}, title = {{Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk}}, journal = {Annals of Neurology}, year = {2026}, doi = {10.1002/ana.78303}, pmid = {42548036}, url = {https://doi.org/10.1002/ana.78303} } @article{pu2025-40200556, author = {Pu, Lihui and Barton, Matthew and Gamage, Madushika Wishvanie Kodagoda and Okada, Mari and Todorovic, Michael and Moyle, Wendy}, title = {{Pain Assessment and Management in Dementia Care: Qualitative Perspectives of People With Dementia, Their Families, and Healthcare Professionals}}, journal = {Journal of Clinical Nursing}, year = {2025}, doi = {10.1111/jocn.17771}, pmid = {40200556}, url = {https://doi.org/10.1111/jocn.17771} } @article{yu2026-41041540, author = {Yu, Jing and Rosbergen, Mathijs T. and Wolters, Frank J. and Bron, Esther E. and Vernooij, Meike Willemijn and Ikram, M. Arfan and Roshchupkin, Gennady V.}, title = {{Imaging-genetics-based dementia risk prediction using deep survival neural networks in the Rotterdam Study}}, journal = {Scientific Reports}, year = {2026}, doi = {10.1038/s41598-026-47047-y}, pmid = {41041540}, url = {https://doi.org/10.1038/s41598-026-47047-y} } @article{riedijk2006-16966830, author = {Riedijk, SR. and De Vugt, M. E. and Duivenvoorden, H. J. and Niermeijer, M. F. and Van Swieten, J. C. and Verhey, F. R. and Tibben, A.}, title = {{Caregiver burden, health-related quality of life and coping in dementia caregivers: a comparison of frontotemporal dementia and Alzheimer's disease}}, journal = {Dementia and geriatric cognitive disorders}, year = {2006}, doi = {10.1159/000095750}, pmid = {16966830}, url = {https://doi.org/10.1159/000095750} } @article{darweesh2019-31515066, author = {Darweesh, S. K. L. and Licher, S. and Wolters, F. J. and Koudstaal, P. J. and Ikram, M. K. and Ikram, M. A.}, title = {{Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.03.013}, pmid = {31515066}, url = {https://doi.org/10.1016/j.jalz.2019.03.013} } @article{kukkle2025-40898879, author = {Kukkle, Prashanth Lingappa and Neupane, Rosy and Pantelyat, Alexander Y. and Wills, Anne-Marie A. and Jabbari, Edwin and Dopper, Elise G.P. and Kovács, Gábor Géza and Höglinger, Günter U. and others}, title = {{Progressive Supranuclear Palsy—A Global Review}}, journal = {Movement Disorders Clinical Practice}, year = {2025}, doi = {10.1002/mdc3.70338}, pmid = {40898879}, url = {https://doi.org/10.1002/mdc3.70338} } @article{calia2025-40819654, author = {Calia, Clara and O’Donald, Freddie and Franzen, Sanne and Alvarez, A and Dreyer, Anna J. and Ibáñez-Casas, Inmaculada and Jiang, Jessica and Daugherty, Julia C. and others}, title = {{Cross-cultural functional assessment for dementia: A commentary}}, journal = {The Clinical Neuropsychologist}, year = {2025}, doi = {10.1080/13854046.2025.2543913}, pmid = {40819654}, url = {https://doi.org/10.1080/13854046.2025.2543913} } @article{ho2025-40965463, author = {Ho, Phuong Thuy Nguyen and Vernooij, Meike Willemijn and Voortman, Trudy and Rodríguez‐Ayllón, María and Neitzel, Julia}, title = {{Objective physical activity and Alzheimer's disease burden in the population‐based Rotterdam Study}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70655}, pmid = {40965463}, url = {https://doi.org/10.1002/alz.70655} } @article{hoepel2025-40793962, author = {Hoepel, Sanne J W and Ikram, M. Kamran and Ikram, M. Arfan and Voortman, Trudy and Luik, Annemarie Ida}, title = {{Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke}}, journal = {Journal of Sleep Research}, year = {2025}, doi = {10.1111/jsr.70166}, pmid = {40793962}, url = {https://doi.org/10.1111/jsr.70166} } @article{prinse2025-40754329, author = {Prinse, F. A. M. and van der Weerd, L. and van Swieten, J. C. and Ronen, I. and Seelaar, H. and Hirschler, L. and Najac, C. and Dopper, E. G. P.}, title = {{Investigating the role of neuroinflammation and brain clearance in frontotemporal lobar degeneration using 7T MRI and fluid biomarkers: protocol for a cross-sectional study in a tertiary care setting}}, journal = {BMJ open}, year = {2025}, doi = {10.1136/bmjopen-2025-102668}, pmid = {40754329}, url = {https://doi.org/10.1136/bmjopen-2025-102668} } @article{zarea2026-42215639, author = {Zaréa, Aline and Cassinari, Kévin and Lecoquierre, François and Quenez, Olivier and Charbonnier, Camille and Schramm, Catherine and Lacour, Morgane and Rousseau, Stéphane and others}, title = {{Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios}}, journal = {Molecular Psychiatry}, year = {2026}, doi = {10.1038/s41380-026-03665-6}, pmid = {42215639}, url = {https://doi.org/10.1038/s41380-026-03665-6} } @article{miedema2025-40713859, author = {Miedema, Suzanne S. M. and Rajicic, Ana and Mol, Merel O. and Paliukhovich, Iryna and Klaassen, Remco V. and van Buuren, Renee and Li, Ka Wan and Koopmans, Frank and others}, title = {{Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome}}, journal = {Acta Neuropathologica Communications}, year = {2025}, doi = {10.1186/s40478-025-02077-x}, pmid = {40713859}, url = {https://doi.org/10.1186/s40478-025-02077-x} } @article{dellarole2025-41399249, author = {Dellarole, Ilaria Linda and Aprea, Vittoria and Catania, Marcella and Battipaglia, Claudia and Romeo, Aurora and Villa, Cristina and Burato, Anna and Celauro, Luigi and others}, title = {{Detection of TDP‐43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70989}, pmid = {41399249}, url = {https://doi.org/10.1002/alz.70989} } @article{ulugut2025-41387629, author = {Ulugut, Hülya and Younes, Kyan and Montembeault, Maxime and Bertoux, Maxime and Irish, Muireann and Kumfor, Fiona and Fumagalli, Giorgio and Samancı, Bedia and others}, title = {{Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group}}, journal = {Communications Medicine}, year = {2025}, doi = {10.1038/s43856-025-01252-4}, pmid = {41387629}, url = {https://doi.org/10.1038/s43856-025-01252-4} } @article{graafland2025-40502924, author = {Graafland, Charlotte H and Kaat, Laura Donker and Richard, Edo and Van Swieten, John Cornelis and Seelaar, Harro and Bunnik, Eline Maria}, title = {{Ethics of disclosure of onset‐predictive biomarker test results for genetic frontotemporal dementia in the research context}}, journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring}, year = {2025}, doi = {10.1002/dad2.70133}, pmid = {40502924}, url = {https://doi.org/10.1002/dad2.70133} } @article{claus2025-40344552, author = {Claus, Jacqueline Josephine and Rosbergen, Mathijs T. and Labrecque, Jeremy Alexander and Vernooij, Meike Willemijn and Wolters, Frank J. and Ikram, M. Arfan}, title = {{Mediation of the Association Between APOE ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213679}, pmid = {40344552}, url = {https://doi.org/10.1212/wnl.0000000000213679} } @article{vandersteen2025-59bd41a0, author = {van der Steen, Jenny Theodora and Van den Block, Lieve and Nakanishi, Miharu and der Schmitten, Jürgen in and Sudore, Rebecca L. and Korfage, Ida J.}, title = {{Ambiguities About Discussing End of Life in the Context of Advance Care Planning in Dementia}}, journal = {Innovation in Aging}, year = {2025}, doi = {10.1093/geroni/igaf122.2601}, url = {https://doi.org/10.1093/geroni/igaf122.2601} } @article{cunha2026-beffb111, author = {Cunha, C. and Garcia-Urena, M. and Martinez, R. and Romero-Lado, M. J. and Fernandez, M. V. and Andreassen, O. A. and Sims, R. and Tsolaki and others}, title = {{Genomics link obesity and type 2 diabetes to Alzheimers disease to unveil novel biological insights}}, journal = {medRxiv (preprint)}, year = {2026}, doi = {10.64898/2026.02.10.26344393}, url = {https://doi.org/10.64898/2026.02.10.26344393} }