% alzhub.org library filter % Source: https://alzhub.org/research?institution=I135140700 % 136 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{kunkle2019-30820047, author = {Kunkle, B. W. and Grenier-Boley, B. and Sims, R. and Bis, J. C. and Damotte, V. and Naj, A. C. and Boland, A. and Vronskaya, M. and others}, title = {{Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing}}, journal = {Nature genetics}, year = {2019}, doi = {10.1038/s41588-019-0358-2}, pmid = {30820047}, url = {https://doi.org/10.1038/s41588-019-0358-2} } @article{jansen2015-25988462, author = {Jansen, W. J. and Ossenkoppele, R. and Knol, D. L. and Tijms, B. M. and Scheltens, P. and Verhey, F. R. and Visser, P. J. and {Amyloid Biomarker Study Group} and others}, title = {{Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis}}, journal = {JAMA}, year = {2015}, doi = {10.1001/jama.2015.4668}, pmid = {25988462}, url = {https://doi.org/10.1001/jama.2015.4668} } @article{sims2017-28714976, author = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others}, title = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}}, journal = {Nature genetics}, year = {2017}, doi = {10.1038/ng.3916}, pmid = {28714976}, url = {https://doi.org/10.1038/ng.3916} } @article{jun2016-25778476, author = {Jun, G. and Ibrahim-Verbaas, C. A. and Vronskaya, M. and Lambert, J. C. and Chung, J. and Naj, A. C. and Kunkle, B. W. and Wang, L. S. and others}, title = {{A novel Alzheimer disease locus located near the gene encoding tau protein}}, journal = {Molecular psychiatry}, year = {2016}, doi = {10.1038/mp.2015.23}, pmid = {25778476}, url = {https://doi.org/10.1038/mp.2015.23} } @article{jansen2022-36066633, author = {Jansen, I. E. and van der Lee, S. J. and Gomez-Fonseca, D. and de Rojas, I. and Dalmasso, M. C. and Grenier-Boley, B. and Zettergren, A. and Mishra, A. and others}, title = {{Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers}}, journal = {Acta neuropathologica}, year = {2022}, doi = {10.1007/s00401-022-02454-z}, pmid = {36066633}, url = {https://doi.org/10.1007/s00401-022-02454-z} } @article{temba2025-40181181, author = {Temba, Godfrey S. and Pecht, Tal and Kullaya, Vesla I. and Vadaq, Nadira and Mosha, Mary and Ulas, Thomas and Kanungo, Sneha and van Emst, Liesbeth and others}, title = {{Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial}}, journal = {Nature Medicine}, year = {2025}, doi = {10.1038/s41591-025-03602-0}, pmid = {40181181}, url = {https://doi.org/10.1038/s41591-025-03602-0} } @article{maier2020-32463470, author = {Maier, F. and Spottke, A. and Bach, J. P. and Bartels, C. and Buerger, K. and Dodel, R. and Fellgiebel, A. and Fliessbach, K. and others}, title = {{Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2020}, doi = {10.1001/jamanetworkopen.2020.6027}, pmid = {32463470}, url = {https://doi.org/10.1001/jamanetworkopen.2020.6027} } @article{jansen2022-35099509, author = {Jansen, W. J. and Janssen, O. and Tijms, B. M. and Vos, S. J. B. and Ossenkoppele, R. and Visser, P. J. and {Amyloid Biomarker Study Group} and Aarsland, D. and others}, title = {{Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2021.5216}, pmid = {35099509}, url = {https://doi.org/10.1001/jamaneurol.2021.5216} } @article{gomm2016-26882076, author = {Gomm, W. and von Holt, K. and Thomé, F. and Broich, K. and Maier, W. and Fink, A. and Doblhammer, G. and Haenisch, B.}, title = {{Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2015.4791}, pmid = {26882076}, url = {https://doi.org/10.1001/jamaneurol.2015.4791} } @article{holstege2022-36411364, author = {Holstege, H. and Hulsman, M. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Grozeva, D. and van Rooij, J. G. J. and Sims, R. and others}, title = {{Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease}}, journal = {Nature genetics}, year = {2022}, doi = {10.1038/s41588-022-01208-7}, pmid = {36411364}, url = {https://doi.org/10.1038/s41588-022-01208-7} } @article{saadmaan2026-40747850, author = {Saadmaan, Gazi and Dalmasso, Maria Carolina and Maria, Maleeha and Lehtisalo, Jenni and Hiltunen, Mikko and Kaikkonen, Minna U and Levälahti, Esko and Mangialasche, Francesca and others}, title = {{Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial}}, journal = {Brain : a journal of neurology}, year = {2026}, doi = {10.1093/brain/awaf277}, pmid = {40747850}, url = {https://doi.org/10.1093/brain/awaf277} } @article{leguen2022-35639372, author = {Le Guen, Y. and Belloy, M. E. and Grenier-Boley, B. and de Rojas, I. and Castillo-Morales, A. and Jansen, I. and Nicolas, A. and Bellenguez, C. and others}, title = {{Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.1166}, pmid = {35639372}, url = {https://doi.org/10.1001/jamaneurol.2022.1166} } @article{jessen2010-20368517, author = {Jessen, F. and Wiese, B. and Bachmann, C. and Eifflaender-Gorfer, S. and Haller, F. and Kölsch, H. and Luck, T. and Mösch, E. and others}, title = {{Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment}}, journal = {Archives of general psychiatry}, year = {2010}, doi = {10.1001/archgenpsychiatry.2010.30}, pmid = {20368517}, url = {https://doi.org/10.1001/archgenpsychiatry.2010.30} } @article{kleineidam2020-32166339, author = {Kleineidam, L. and Chouraki, V. and Próchnicki, T. and van der Lee, S. J. and Madrid-Márquez, L. and Wagner-Thelen, H. and Karaca, I. and Weinhold, L. and others}, title = {{PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment}}, journal = {Acta neuropathologica}, year = {2020}, doi = {10.1007/s00401-020-02138-6}, pmid = {32166339}, url = {https://doi.org/10.1007/s00401-020-02138-6} } @article{stark2023-37821235, author = {Stark, M. and Wolfsgruber, S. and Kleineidam, L. and Frommann, I. and Altenstein, S. and Bartels, C. and Brosseron, F. and Buerger, K. and others}, title = {{Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207844}, pmid = {37821235}, url = {https://doi.org/10.1212/wnl.0000000000207844} } @article{hajek2015-26658776, author = {Hajek, A. and Brettschneider, C. and Lange, C. and Posselt, T. and Wiese, B. and Steinmann, S. and Weyerer, S. and Werle, J. and others}, title = {{Longitudinal Predictors of Institutionalization in Old Age}}, journal = {PloS one}, year = {2015}, doi = {10.1371/journal.pone.0144203}, pmid = {26658776}, url = {https://doi.org/10.1371/journal.pone.0144203} } @article{jessen2014-23375567, author = {Jessen, F. and Wolfsgruber, S. and Wiese, B. and Bickel, H. and Mösch, E. and Kaduszkiewicz, H. and Pentzek, M. and Riedel-Heller, S. G. and others}, title = {{AD dementia risk in late MCI, in early MCI, and in subjective memory impairment}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2014}, doi = {10.1016/j.jalz.2012.09.017}, pmid = {23375567}, url = {https://doi.org/10.1016/j.jalz.2012.09.017} } @article{lambert2013-24162737, author = {Lambert, Jean‐Charles and Ibrahim‐Verbaas, Carla A. and Harold, Denise H. and Naj, Adam Christian and Sims, Rebecca and Bellenguez, Céline and others}, title = {{Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease}}, journal = {Nature Genetics}, year = {2013}, doi = {10.1038/ng.2802}, pmid = {24162737}, url = {https://doi.org/10.1038/ng.2802} } @article{harold2009-19734902, author = {Harold, Denise H. and Abraham, Richard and Hollingworth, Paul and Sims, Rebecca and Gerrish, Amy and Hamshere, Marian L. and Pahwa, Jaspreet Singh and Moskvina, Valentina and others}, title = {{Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease}}, journal = {Nature Genetics}, year = {2009}, doi = {10.1038/ng.440}, pmid = {19734902}, url = {https://doi.org/10.1038/ng.440} } @article{study2011-21460840, author = {{the Alzheimer's Disease Neuroimaging Initiative} and Hollingworth, Paul and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Lambert, Jean‐Charles and Carrasquillo, Minerva M. and Abraham, Richard and others}, title = {{Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease}}, journal = {Nature Genetics}, year = {2011}, doi = {10.1038/ng.803}, pmid = {21460840}, url = {https://doi.org/10.1038/ng.803} } @article{mengel2025-40247130, author = {Mengel, D. and Soter, E. and Ott, J. M. and Wacker, M. and Leyva, A. and Peters, O. and Hellmann-Regen, J. and Schneider, L. S. and others}, title = {{Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease}}, journal = {Molecular psychiatry}, year = {2025}, doi = {10.1038/s41380-025-03021-0}, pmid = {40247130}, url = {https://doi.org/10.1038/s41380-025-03021-0} } @article{mauschitz2018-29716786, author = {Mauschitz, M. M. and Bonnemaijer, P. W. M. and Diers, K. and Rauscher, F. G. and Elze, T. and Engel, C. and Loeffler, M. and Colijn, J. M. and others}, title = {{Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population}}, journal = {Ophthalmology}, year = {2018}, doi = {10.1016/j.ophtha.2018.03.026}, pmid = {29716786}, url = {https://doi.org/10.1016/j.ophtha.2018.03.026} } @article{hooli2014-25186855, author = {Hooli, B. V. and Parrado, A. R. and Mullin, K. and Yip, W. K. and Liu, T. and Roehr, J. T. and Qiao, D. and Jessen, F. and others}, title = {{The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000855}, pmid = {25186855}, url = {https://doi.org/10.1212/wnl.0000000000000855} } @article{martinoadami2024-39253733, author = {Martino-Adami, P. V. and Chatterjee, M. and Kleineidam, L. and Weyerer, S. and Bickel, H. and Wiese, B. and Riedel-Heller, S. G. and Scherer, M. and others}, title = {{Prognostic value of Alzheimer's disease plasma biomarkers in the oldest-old: a prospective primary care-based study}}, journal = {The Lancet regional health. Europe}, year = {2024}, doi = {10.1016/j.lanepe.2024.101030}, pmid = {39253733}, url = {https://doi.org/10.1016/j.lanepe.2024.101030} } @article{scheltens2016-26921134, author = {Scheltens, P. and Blennow, K. and Breteler, M. M. and de Strooper, B. and Frisoni, G. B. and Salloway, S. and Van der Flier, W. M.}, title = {{Alzheimer's disease}}, journal = {Lancet (London, England)}, year = {2016}, doi = {10.1016/s0140-6736(15)01124-1}, pmid = {26921134}, url = {https://doi.org/10.1016/s0140-6736(15)01124-1} } @article{vanes2009-19734901, author = {van Es, M. A. and Veldink, J. H. and Saris, C. G. and Blauw, H. M. and van Vught, P. W. and Birve, A. and Lemmens, R. and Schelhaas, H. J. and others}, title = {{Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis}}, journal = {Nature genetics}, year = {2009}, doi = {10.1038/ng.442}, pmid = {19734901}, url = {https://doi.org/10.1038/ng.442} } @article{slot2019-30555032, author = {Slot, R. E. R. and Sikkes, S. A. M. and Berkhof, J. and Brodaty, H. and Buckley, R. and Cavedo, E. and Dardiotis, E. and Guillo-Benarous, F. and others}, title = {{Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2018.10.003}, pmid = {30555032}, url = {https://doi.org/10.1016/j.jalz.2018.10.003} } @article{heneka2015-25792098, author = {Heneka, Michael Thomas and Carson, Monica J. and El Khoury, Joseph B. and Landreth, Gary E. and Brosseron, Frederic and Feinstein, Douglas L. and Jacobs, Andreas Hans and Wyss‐Coray, Tony and others}, title = {{Neuroinflammation in Alzheimer's disease}}, journal = {The Lancet Neurology}, year = {2015}, doi = {10.1016/s1474-4422(15)70016-5}, pmid = {25792098}, url = {https://doi.org/10.1016/s1474-4422(15)70016-5} } @article{haenisch2015-25341874, author = {Haenisch, B. and von Holt, K. and Wiese, B. and Prokein, J. and Lange, C. and Ernst, A. and Brettschneider, C. and König, H. H. and others}, title = {{Risk of dementia in elderly patients with the use of proton pump inhibitors}}, journal = {European archives of psychiatry and clinical neuroscience}, year = {2015}, doi = {10.1007/s00406-014-0554-0}, pmid = {25341874}, url = {https://doi.org/10.1007/s00406-014-0554-0} } @article{vos2015-25693589, author = {Vos, S. J. and Verhey, F. and Frölich, L. and Kornhuber, J. and Wiltfang, J. and Maier, W. and Peters, O. and Rüther, E. and others}, title = {{Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage}}, journal = {Brain : a journal of neurology}, year = {2015}, doi = {10.1093/brain/awv029}, pmid = {25693589}, url = {https://doi.org/10.1093/brain/awv029} } @article{ising2019-31748742, author = {Ising, Christina and Venegas, Carmen and Zhang, Shuangshuang and Scheiblich, Hannah and Schmidt, Susanne V. and Vieira-Saecker, Ana Maria Menezes and Schwartz, Stephanie and Albasset, Shadi and McManus, Róisín M. and Tejera, Darío and Griep, Angelika and Santarelli, Francesco and Brosseron, Frederic and Opitz, Sabine and Stunden, James and Merten, Maximilian and Kayed, Rakez and Golenbock, Douglas Taylor and Blum, David L and Latz, Eicke and Buée, Luc and Heneka, Michael Thomas}, title = {{NLRP3 inflammasome activation drives tau pathology}}, journal = {Nature}, year = {2019}, doi = {10.1038/s41586-019-1769-z}, pmid = {31748742}, url = {https://doi.org/10.1038/s41586-019-1769-z} } @article{heneka2013-23254930, author = {Heneka, M. T. and Kummer, M. P. and Stutz, A. and Delekate, A. and Schwartz, S. and Vieira-Saecker, A. and Griep, A. and Axt, D. and others}, title = {{NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice}}, journal = {Nature}, year = {2013}, doi = {10.1038/nature11729}, pmid = {23254930}, url = {https://doi.org/10.1038/nature11729} } @article{jansen2018-29188296, author = {Jansen, W. J. and Ossenkoppele, R. and Tijms, B. M. and Fagan, A. M. and Hansson, O. and Klunk, W. E. and van der Flier, W. M. and Villemagne, V. L. and others}, title = {{Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia}}, journal = {JAMA psychiatry}, year = {2018}, doi = {10.1001/jamapsychiatry.2017.3391}, pmid = {29188296}, url = {https://doi.org/10.1001/jamapsychiatry.2017.3391} } @article{filler2025-40893447, author = {Filler, Jule and Georgakis, Marios K. and Janowitz, Daniel and Duering, Marco and Fang, Rong and Dewenter, Anna and Bode, Felix Jürgen and Stoesser, Sebastian and others}, title = {{Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study}}, journal = {The Lancet Regional Health - Europe}, year = {2025}, doi = {10.1016/j.lanepe.2025.101428}, pmid = {40893447}, url = {https://doi.org/10.1016/j.lanepe.2025.101428} } @article{lammerslietz2026-41850989, author = {Lammers‐Lietz, Florian and Akyuez, Levent and Boraschi, Diana and Borchers, Friedrich and de Bresser, Jeroen and Chatterjee, Sreyoshi and Correia, Marta and de Lange, Nikola M. and others}, title = {{Prediction and risk evaluation of delirium after surgery in older patients: development and internal validation of an algorithm from the prospective BioCog cohort study}}, journal = {British Journal of Anaesthesia}, year = {2026}, doi = {10.1016/j.bja.2026.01.025}, pmid = {41850989}, url = {https://doi.org/10.1016/j.bja.2026.01.025} } @article{nicolas2025-40533518, author = {Nicolas, A. and Sherva, R. and Grenier-Boley, B. and Kim, Y. and Kikuchi, M. and Timsina, J. and de Rojas, I. and Dalmasso, M. C. and Zhou, X. and Le Guen, Y. and Arboleda-Bustos, C. E. and Camargos Bicalho, M. A. and others}, title = {{Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations}}, journal = {Nature genetics}, year = {2025}, doi = {10.1038/s41588-025-02227-w}, pmid = {40533518}, url = {https://doi.org/10.1038/s41588-025-02227-w} } @article{meyer2017-28348957, author = {Meyer, S. and Mueller, K. and Stuke, K. and Bisenius, S. and Diehl-Schmid, J. and Jessen, F. and Kassubek, J. and Kornhuber, J. and others}, title = {{Predicting behavioral variant frontotemporal dementia with pattern classification in multi-center structural MRI data}}, journal = {NeuroImage. Clinical}, year = {2017}, doi = {10.1016/j.nicl.2017.02.001}, pmid = {28348957}, url = {https://doi.org/10.1016/j.nicl.2017.02.001} } @article{vanderlee2019-31131421, author = {van der Lee, S. J. and Conway, O. J. and Jansen, I. and Carrasquillo, M. M. and Kleineidam, L. and van den Akker, E. and Hernández, I. and van Eijk, K. R. and others}, title = {{A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity}}, journal = {Acta neuropathologica}, year = {2019}, doi = {10.1007/s00401-019-02026-8}, pmid = {31131421}, url = {https://doi.org/10.1007/s00401-019-02026-8} } @article{dalmasso2019-30705288, author = {Dalmasso, M. C. and Brusco, L. I. and Olivar, N. and Muchnik, C. and Hanses, C. and Milz, E. and Becker, J. and Heilmann-Heimbach, S. and others}, title = {{Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease}}, journal = {Translational psychiatry}, year = {2019}, doi = {10.1038/s41398-019-0394-9}, pmid = {30705288}, url = {https://doi.org/10.1038/s41398-019-0394-9} } @article{jessen2018-29415768, author = {Jessen, F. and Spottke, A. and Boecker, H. and Brosseron, F. and Buerger, K. and Catak, C. and Fliessbach, K. and Franke, C. and others}, title = {{Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE)}}, journal = {Alzheimer's research \& therapy}, year = {2018}, doi = {10.1186/s13195-017-0314-2}, pmid = {29415768}, url = {https://doi.org/10.1186/s13195-017-0314-2} } @article{vanderlee2018-29316447, author = {van der Lee, S. J. and Teunissen, C. E. and Pool, R. and Shipley, M. J. and Teumer, A. and Chouraki, V. and Melo van Lent, D. and Tynkkynen, J. and others}, title = {{Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2018}, doi = {10.1016/j.jalz.2017.11.012}, pmid = {29316447}, url = {https://doi.org/10.1016/j.jalz.2017.11.012} } @article{scheef2012-22914828, author = {Scheef, L. and Spottke, A. and Daerr, M. and Joe, A. and Striepens, N. and Kölsch, H. and Popp, J. and Daamen, M. and others}, title = {{Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e31826c1a8d}, pmid = {22914828}, url = {https://doi.org/10.1212/wnl.0b013e31826c1a8d} } @article{vanmaurik2019-31526625, author = {van Maurik, I. S. and Vos, S. J. and Bos, I. and Bouwman, F. H. and Teunissen, C. E. and Scheltens, P. and Barkhof, F. and Frolich, L. and others}, title = {{Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study}}, journal = {The Lancet. Neurology}, year = {2019}, doi = {10.1016/s1474-4422(19)30283-2}, pmid = {31526625}, url = {https://doi.org/10.1016/s1474-4422(19)30283-2} } @article{jessen2014-24798886, author = {Jessen, Frank and Amariglio, Rebecca England and van Boxtel, Martin P.J. and Breteler, Monique M.B. and Ceccaldi, Mathieu and Chételat, Gaël and Dubois, Bruno and Dufouil, Carole and others}, title = {{A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease}}, journal = {Alzheimer s \& Dementia}, year = {2014}, doi = {10.1016/j.jalz.2014.01.001}, pmid = {24798886}, url = {https://doi.org/10.1016/j.jalz.2014.01.001} } @article{bartels2018-29179578, author = {Bartels, C. and Wagner, M. and Wolfsgruber, S. and Ehrenreich, H. and Schneider, A. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer's Dementia in Individuals With Previous Depression}}, journal = {The American journal of psychiatry}, year = {2018}, doi = {10.1176/appi.ajp.2017.17040404}, pmid = {29179578}, url = {https://doi.org/10.1176/appi.ajp.2017.17040404} } @article{willem2015-26322584, author = {Willem, M. and Tahirovic, S. and Busche, M. A. and Ovsepian, S. V. and Chafai, M. and Kootar, S. and Hornburg, D. and Evans, L. D. and others}, title = {{η-Secretase processing of APP inhibits neuronal activity in the hippocampus}}, journal = {Nature}, year = {2015}, doi = {10.1038/nature14864}, pmid = {26322584}, url = {https://doi.org/10.1038/nature14864} } @article{brosseron2022-34995486, author = {Brosseron, F. and Maass, A. and Kleineidam, L. and Ravichandran, K. A. and González, P. G. and McManus, R. M. and Ising, C. and Santarelli, F. and others}, title = {{Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease}}, journal = {Neuron}, year = {2022}, doi = {10.1016/j.neuron.2021.12.016}, pmid = {34995486}, url = {https://doi.org/10.1016/j.neuron.2021.12.016} } @article{luo2023-37195665, author = {Luo, J. and Thomassen, J. Q. and Bellenguez, C. and Grenier-Boley, B. and de Rojas, I. and Castillo, A. and Parveen, K. and others}, title = {{Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.13734}, pmid = {37195665}, url = {https://doi.org/10.1001/jamanetworkopen.2023.13734} } @article{heneka2025-39653749, author = {Heneka, M. T. and van der Flier, W. M. and Jessen, F. and Hoozemanns, J. and Thal, D. R. and Boche, D. and Brosseron, F. and Teunissen, C. and others}, title = {{Neuroinflammation in Alzheimer disease}}, journal = {Nature reviews. Immunology}, year = {2025}, doi = {10.1038/s41577-024-01104-7}, pmid = {39653749}, url = {https://doi.org/10.1038/s41577-024-01104-7} } @article{lattmann2026-41997924, author = {Lattmann, René and Vockert, Niklas and Bernal, Jose and Wesenberg, Judith and Suksangkharn, Yanin and Yakupov, Renat and Schütze, Hartmut and Glanz, Wenzel and others}, title = {{Dysfunction of the episodic memory network in the Alzheimer’s disease cascade}}, journal = {Nature Communications}, year = {2026}, doi = {10.1038/s41467-026-71831-z}, pmid = {41997924}, url = {https://doi.org/10.1038/s41467-026-71831-z} } @article{thal2002-12084879, author = {Thal, Dietmar Rudolf and Rüb, Udo and Orantes, Mario and Braak, Heiko}, title = {{Phases of Aβ-deposition in the human brain and its relevance for the development of AD}}, journal = {Neurology}, year = {2002}, doi = {10.1212/wnl.58.12.1791}, pmid = {12084879}, url = {https://doi.org/10.1212/wnl.58.12.1791} } @article{zhang2013-23622250, author = {Zhang, Bin and Gaiteri, Chris and Bodea, Liviu‐Gabriel and Wang, Zhi and McElwee, Joshua J. and Podtelezhnikov, Alexei A. and Zhang, Chunsheng and Xie, Tao and Tran, Linh My and Dobrin, Radu and Fluder, Eugene M. and Clurman, Bruce E. and Melquist, Stacey and Narayanan, Manikandan and Suver, Christine and Shah, Hardik and Mahajan, Milind C. and Gillis, Tammy and Mysore, Jayalakshmi Srinidhi and MacDonald, Marcy E. and Lamb, John R. and Bennett, David Alan and Molony, Cliona M. and Stone, David J. and Gudnason, Vilmundur G. and Myers, Amanda and Schadt, Eric E. and Neumann, Harald and Zhu, Jun and Emilsson, Valur}, title = {{Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease}}, journal = {Cell}, year = {2013}, doi = {10.1016/j.cell.2013.03.030}, pmid = {23622250}, url = {https://doi.org/10.1016/j.cell.2013.03.030} } @article{riedel2008-18204803, author = {Riedel, O. and Klotsche, J. and Spottke, A. and Deuschl, G. and Förstl, H. and Henn, F. and Heuser, I. and Oertel, W. and others}, title = {{Cognitive impairment in 873 patients with idiopathic Parkinson's disease. Results from the German Study on Epidemiology of Parkinson's Disease with Dementia (GEPAD)}}, journal = {Journal of neurology}, year = {2008}, doi = {10.1007/s00415-008-0720-2}, pmid = {18204803}, url = {https://doi.org/10.1007/s00415-008-0720-2} } @article{kleinberger2014-24990881, author = {Kleinberger, G. and Yamanishi, Y. and Suárez-Calvet, M. and Czirr, E. and Lohmann, E. and Cuyvers, E. and Struyfs, H. and Pettkus, N. and others}, title = {{TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis}}, journal = {Science translational medicine}, year = {2014}, doi = {10.1126/scitranslmed.3009093}, pmid = {24990881}, url = {https://doi.org/10.1126/scitranslmed.3009093} } @article{quenez2026-42648288, author = {Quenez, O. and Schramm, C. and Cassinari, K. and Nicolas, A. and Groeneveld, J. and Huguet, G. and Grenier-Boley, B. and Hulsman, M. and Walters, G. B. and de Rojas, I. and Rovelet-Lecrux, A. and Feuillette, S. and others}, title = {{Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk}}, journal = {American Journal of Human Genetics}, year = {2026}, doi = {10.1016/j.ajhg.2026.07.013}, pmid = {42648288}, url = {https://doi.org/10.1016/j.ajhg.2026.07.013} } @article{scheiblich2024-39059388, author = {Scheiblich, H. and Eikens, F. and Wischhof, L. and Opitz, S. and Jüngling, K. and Cserép, C. and Schmidt, S. V. and Lambertz, J. and others}, title = {{Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes}}, journal = {Neuron}, year = {2024}, doi = {10.1016/j.neuron.2024.06.029}, pmid = {39059388}, url = {https://doi.org/10.1016/j.neuron.2024.06.029} } @article{zhang2022-35965319, author = {Zhang, X. and Hu, W. and Wang, Y. and Wang, W. and Liao, H. and Kiburg, K. V. and Shang, X. and others}, title = {{Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank}}, journal = {BMC medicine}, year = {2022}, doi = {10.1186/s12916-022-02449-3}, pmid = {35965319}, url = {https://doi.org/10.1186/s12916-022-02449-3} } @article{helmstaedter2009-19635728, author = {Helmstaedter, C. and Elger, C. E.}, title = {{Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease?}}, journal = {Brain : a journal of neurology}, year = {2009}, doi = {10.1093/brain/awp182}, pmid = {19635728}, url = {https://doi.org/10.1093/brain/awp182} } @article{knaul2025-40021301, author = {Knaul, Felícia Marie and Arreola‐Ornelas, Héctor and Kwete, Xiaoxiao Jiang and Bhadelia, Afsan and Rosa, William E. and Touchton, Michael M. and Méndez-Carniado, Oscar and Vargas, Valentina and others}, title = {{The evolution of serious health-related suffering from 1990 to 2021: an update to The Lancet Commission on global access to palliative care and pain relief}}, journal = {The Lancet Global Health}, year = {2025}, doi = {10.1016/s2214-109x(24)00476-5}, pmid = {40021301}, url = {https://doi.org/10.1016/s2214-109x(24)00476-5} } @article{luo2025-40437158, author = {Luo, Hao and Koponen, Marjaana and Roethlein, Christoph and Becker, Cornelia and Bell, J. Simon and Beyene, Kebede Abera and Chai, Yi and Chan, Amy Hai Yan and others}, title = {{A multinational cohort study of trends in survival following dementia diagnosis}}, journal = {Communications Medicine}, year = {2025}, doi = {10.1038/s43856-025-00923-6}, pmid = {40437158}, url = {https://doi.org/10.1038/s43856-025-00923-6} } @article{jones2010-21085570, author = {Jones, L. and Holmans, P. A. and Hamshere, M. L. and Harold, D. and Moskvina, V. and Ivanov, D. and Pocklington, A. and Abraham, R. and others}, title = {{Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease}}, journal = {PloS one}, year = {2010}, doi = {10.1371/journal.pone.0013950}, pmid = {21085570}, url = {https://doi.org/10.1371/journal.pone.0013950} } @article{brosseron2018-29482610, author = {Brosseron, F. and Traschütz, A. and Widmann, C. N. and Kummer, M. P. and Tacik, P. and Santarelli, F. and Jessen, F. and Heneka, M. T.}, title = {{Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2018}, doi = {10.1186/s13195-018-0353-3}, pmid = {29482610}, url = {https://doi.org/10.1186/s13195-018-0353-3} } @article{fassbender2001-11296263, author = {Fassbender, K. and Simons, M. and Bergmann, C. and Stroick, M. and Lutjohann, D. and Keller, P. and Runz, H. and Kuhl, S. and others}, title = {{Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2001}, doi = {10.1073/pnas.081620098}, pmid = {11296263}, url = {https://doi.org/10.1073/pnas.081620098} } @article{melovanlent2021-34092629, author = {Melo van Lent, D. and O'Donnell, A. and Beiser, A. S. and Vasan, R. S. and DeCarli, C. S. and Scarmeas, N. and Wagner, M. and Jacques, P. F. and others}, title = {{Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2021}, doi = {10.3233/jad-201238}, pmid = {34092629}, url = {https://doi.org/10.3233/jad-201238} } @article{tejera2019-31359456, author = {Tejera, D. and Mercan, D. and Sanchez-Caro, J. M. and Hanan, M. and Greenberg, D. and Soreq, H. and Latz, E. and Golenbock, D. and others}, title = {{Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome}}, journal = {The EMBO journal}, year = {2019}, doi = {10.15252/embj.2018101064}, pmid = {31359456}, url = {https://doi.org/10.15252/embj.2018101064} } @article{boeing2012-22684631, author = {Boeing, H. and Bechthold, A. and Bub, A. and Ellinger, S. and Haller, D. and Kroke, A. and Leschik-Bonnet, E. and Müller, M. J. and others}, title = {{Critical review: vegetables and fruit in the prevention of chronic diseases}}, journal = {European journal of nutrition}, year = {2012}, doi = {10.1007/s00394-012-0380-y}, pmid = {22684631}, url = {https://doi.org/10.1007/s00394-012-0380-y} } @article{tirado2026-41526401, author = {Tirado, Gabriel Martínez and Conde, Patricia Martins and Sapienza, Stefano and Fröhlich, Holger and Pauly, Claire and Schröder, Valerie E. and Jónsdóttir, Sonja and Tsurkalenko, Olena and others}, title = {{Data-driven clinical decision support tool for diagnosing mild cognitive impairment in Parkinson’s disease}}, journal = {npj Parkinson s Disease}, year = {2026}, doi = {10.1038/s41531-025-01222-6}, pmid = {41526401}, url = {https://doi.org/10.1038/s41531-025-01222-6} } @article{solomon2014-24605807, author = {Solomon, A. and Mangialasche, F. and Richard, E. and Andrieu, S. and Bennett, D. A. and Breteler, M. and Fratiglioni, L. and Hooshmand, B. and others}, title = {{Advances in the prevention of Alzheimer's disease and dementia}}, journal = {Journal of internal medicine}, year = {2014}, doi = {10.1111/joim.12178}, pmid = {24605807}, url = {https://doi.org/10.1111/joim.12178} } @article{rabin2015-26402085, author = {Rabin, L. A. and Smart, C. M. and Crane, P. K. and Amariglio, R. E. and Berman, L. M. and Boada, M. and Buckley, R. F. and Chételat, G. and others}, title = {{Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2015}, doi = {10.3233/jad-150154}, pmid = {26402085}, url = {https://doi.org/10.3233/jad-150154} } @article{takahashi2007-17425404, author = {Takahashi, K. and Prinz, M. and Stagi, M. and Chechneva, O. and Neumann, H.}, title = {{TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis}}, journal = {PLoS medicine}, year = {2007}, doi = {10.1371/journal.pmed.0040124}, pmid = {17425404}, url = {https://doi.org/10.1371/journal.pmed.0040124} } @article{xu2025-40957850, author = {Xu, Jingyuan and Smaling, Hanneke J. A. and Nakanishi, Miharu and Shinan‐Altman, Shiri and Radbruch, Lukas and Gaertner, Jan and Achterberg, Wilco P. and Mehr, David R. and others}, title = {{Acceptability of Euthanasia for People With Dementia: Perspectives of Clinicians From Six Countries}}, journal = {American Journal of Geriatric Psychiatry}, year = {2025}, doi = {10.1016/j.jagp.2025.08.003}, pmid = {40957850}, url = {https://doi.org/10.1016/j.jagp.2025.08.003} } @article{glaser2025-40571933, author = {Gläser, E. and Kilimann, I. and Platen, M. and Hoffmann, W. and Brosseron, F. and Buerger, K. and Coenjaerts, M. and Düzel, E. and Ewers, M. and Fliessbach, K. and Frommann, I. and Gemenetzi, M. and others}, title = {{The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-025-01785-9}, pmid = {40571933}, url = {https://doi.org/10.1186/s13195-025-01785-9} } @article{birkenbihl2020-32843907, author = {Birkenbihl, C. and Emon, M. A. and Vrooman, H. and Westwood, S. and Lovestone, S. and {AddNeuroMed Consortium} and Hofmann-Apitius, M. and Fröhlich, H. and others}, title = {{Differences in cohort study data affect external validation of artificial intelligence models for predictive diagnostics of dementia - lessons for translation into clinical practice}}, journal = {The EPMA journal}, year = {2020}, doi = {10.1007/s13167-020-00216-z}, pmid = {32843907}, url = {https://doi.org/10.1007/s13167-020-00216-z} } @article{vilalta2021-33823153, author = {Vilalta, A. and Zhou, Y. and Sevalle, J. and Griffin, J. K. and Satoh, K. and Allendorf, D. H. and De, S. and Puigdellívol, M. and others}, title = {{Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation}}, journal = {The Journal of biological chemistry}, year = {2021}, doi = {10.1016/j.jbc.2021.100631}, pmid = {33823153}, url = {https://doi.org/10.1016/j.jbc.2021.100631} } @article{ahmad2024-39080778, author = {Ahmad, S. and Yang, W. and Orellana, A. and Frölich, L. and de Rojas, I. and Cano, A. and Boada, M. and Hernández, I. and others}, title = {{Association of oxidative stress and inflammatory metabolites with Alzheimer's disease cerebrospinal fluid biomarkers in mild cognitive impairment}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01542-4}, pmid = {39080778}, url = {https://doi.org/10.1186/s13195-024-01542-4} } @article{schirge2025-40098158, author = {Schirge, P. M. and Perneczky, R. and Taoka, T. and Ruiz-Rizzo, A. L. and Ersoezlue, E. and Forbrig, R. and Guersel, S. and Kurz, C. and others}, title = {{Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-025-01707-9}, pmid = {40098158}, url = {https://doi.org/10.1186/s13195-025-01707-9} } @article{blujdea2026-41814022, author = {Blujdea, Elena Raluca and van Bokhoven, Pieter and Adami, Pamela V. Martino and Marshe, Victoria S. and Vromen, Ellen and Hok-A-Hin, Yanaika Sylvana and Boiten, Walter A. and Irwin, David John and others}, title = {{Microglia protein profiles in CSF across Alzheimer’s disease clinical stages}}, journal = {Nature Aging}, year = {2026}, doi = {10.1038/s43587-026-01088-0}, pmid = {41814022}, url = {https://doi.org/10.1038/s43587-026-01088-0} } @article{cetindag2026-41905188, author = {Cetindag, A. C. and Schipke, C. G. and Esselmann, H. and Kruse, N. and Wiltfang, J. and Schneider, A. and Fliessbach, K. and Miklitz, C. and others}, title = {{Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100544}, pmid = {41905188}, url = {https://doi.org/10.1016/j.tjpad.2026.100544} } @article{thomassen2026-42736378, author = {Thomassen, J. Q. and Leonard, H. and Ulms, B. and Grenier-Boley, B. and Heikkinen, S. and Garcia-González, P. and Castillo-Morales, A. and Kikuchi, M. and Gim, J. and Cao, H. and Küçükali, F. and Amin, N. and others}, title = {{APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease}}, journal = {Nature genetics}, year = {2026}, doi = {10.1038/s41588-026-02713-9}, pmid = {42736378}, url = {https://doi.org/10.1038/s41588-026-02713-9} } @article{lutjohann2000-10681402, author = {Lütjohann, D. and Papassotiropoulos, A. and Björkhem, I. and Locatelli, S. and Bagli, M. and Oehring, R. D. and Schlegel, U. and Jessen, F. and others}, title = {{Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients}}, journal = {Journal of lipid research}, year = {2000}, doi = {10.1016/s0022-2275(20)32052-6}, pmid = {10681402}, url = {https://doi.org/10.1016/s0022-2275(20)32052-6} } @article{luck2007-17848793, author = {Luck, T. and Riedel-Heller, S. G. and Kaduszkiewicz, H. and Bickel, H. and Jessen, F. and Pentzek, M. and Wiese, B. and Koelsch, H. and others}, title = {{Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)}}, journal = {Dementia and geriatric cognitive disorders}, year = {2007}, doi = {10.1159/000108099}, pmid = {17848793}, url = {https://doi.org/10.1159/000108099} } @article{bertram2026-42286243, author = {Bertram, David and Ophey, Anja and Röttgen, Sinah and Kufer, Konstantin and Merten, Nele and Fink, Gereon R. and Kalbe, Elke and Hansen, Clint and others}, title = {{ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy}}, journal = {npj Digital Medicine}, year = {2026}, doi = {10.1038/s41746-026-02738-8}, pmid = {42286243}, url = {https://doi.org/10.1038/s41746-026-02738-8} } @article{garciareitboeck2018-30157425, author = {Garcia-Reitboeck, P. and Phillips, A. and Piers, T. M. and Villegas-Llerena, C. and Butler, M. and Mallach, A. and Rodrigues, C. and Arber, C. E. and others}, title = {{Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis}}, journal = {Cell reports}, year = {2018}, doi = {10.1016/j.celrep.2018.07.094}, pmid = {30157425}, url = {https://doi.org/10.1016/j.celrep.2018.07.094} } @article{franzmeier2021-30899092, author = {Franzmeier, N. and Ren, J. and Damm, A. and Monté-Rubio, G. and Boada, M. and Ruiz, A. and Ramirez, A. and Jessen, F. and others}, title = {{The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2021}, doi = {10.1038/s41380-019-0404-6}, pmid = {30899092}, url = {https://doi.org/10.1038/s41380-019-0404-6} } @article{schmidburgk2016-26553871, author = {Schmid-Burgk, J. L. and Chauhan, D. and Schmidt, T. and Ebert, T. S. and Reinhardt, J. and Endl, E. and Hornung, V.}, title = {{A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation}}, journal = {The Journal of biological chemistry}, year = {2016}, doi = {10.1074/jbc.c115.700492}, pmid = {26553871}, url = {https://doi.org/10.1074/jbc.c115.700492} } @article{corder2004-15246987, author = {Corder, E. H. and Ghebremedhin, E. and Taylor, M. G. and Thal, D. R. and Ohm, T. G. and Braak, H.}, title = {{The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism}}, journal = {Annals of the New York Academy of Sciences}, year = {2004}, doi = {10.1196/annals.1297.005}, pmid = {15246987}, url = {https://doi.org/10.1196/annals.1297.005} } @article{papassotiropoulos2002-11755458, author = {Papassotiropoulos, A. and Lütjohann, D. and Bagli, M. and Locatelli, S. and Jessen, F. and Buschfort, R. and Ptok, U. and Björkhem, I. and others}, title = {{24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia}}, journal = {Journal of psychiatric research}, year = {2002}, doi = {10.1016/s0022-3956(01)00050-4}, pmid = {11755458}, url = {https://doi.org/10.1016/s0022-3956(01)00050-4} } @article{wunderlich2013-24078628, author = {Wunderlich, P. and Glebov, K. and Kemmerling, N. and Tien, N. T. and Neumann, H. and Walter, J.}, title = {{Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage}}, journal = {The Journal of biological chemistry}, year = {2013}, doi = {10.1074/jbc.m113.517540}, pmid = {24078628}, url = {https://doi.org/10.1074/jbc.m113.517540} } @article{linnartzgerlach2019-30548312, author = {Linnartz-Gerlach, B. and Bodea, L. G. and Klaus, C. and Ginolhac, A. and Halder, R. and Sinkkonen, L. and Walter, J. and Colonna, M. and others}, title = {{TREM2 triggers microglial density and age-related neuronal loss}}, journal = {Glia}, year = {2019}, doi = {10.1002/glia.23563}, pmid = {30548312}, url = {https://doi.org/10.1002/glia.23563} } @article{mcmanus2017-28259169, author = {McManus, R. M. and Heneka, M. T.}, title = {{Role of neuroinflammation in neurodegeneration: new insights}}, journal = {Alzheimer's research \& therapy}, year = {2017}, doi = {10.1186/s13195-017-0241-2}, pmid = {28259169}, url = {https://doi.org/10.1186/s13195-017-0241-2} } @article{rodriguez2026-42115891, author = {Rodriguez, Francisca Saveria and Kleineidam, Luca and Hoffmann, Wolfgang and Peters, Oliver and Gref, Daria and Senden, Louise Droste zu and Priller, Josef and Spruth, Eike Jakob and others}, title = {{Non-economic social deprivation and cognitive functioning later in life: Results from the DELCODE study}}, journal = {Journal of Alzheimer s Disease}, year = {2026}, doi = {10.1177/13872877261449395}, pmid = {42115891}, url = {https://doi.org/10.1177/13872877261449395} } @article{alexopoulou2025-40415342, author = {Alexopoulou, Zampeta-Sofia and Köhler, Stefanie and Mallick, Elisa and Tröger, Johannes and Linz, Nicklas and Spruth, Eike Jakob and Fließbach, Klaus and Bartels, Claudia and others}, title = {{Speech-based digital cognitive assessments for detection of mild cognitive impairment: Validation against paper-based neurocognitive assessment scores}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251343296}, pmid = {40415342}, url = {https://doi.org/10.1177/13872877251343296} } @article{thal2002-11895043, author = {Thal, D. R. and Ghebremedhin, E. and Rüb, U. and Yamaguchi, H. and Del Tredici, K. and Braak, H.}, title = {{Two types of sporadic cerebral amyloid angiopathy}}, journal = {Journal of neuropathology and experimental neurology}, year = {2002}, doi = {10.1093/jnen/61.3.282}, pmid = {11895043}, url = {https://doi.org/10.1093/jnen/61.3.282} } @article{popp2015-25435336, author = {Popp, J. and Wolfsgruber, S. and Heuser, I. and Peters, O. and Hüll, M. and Schröder, J. and Möller, H. J. and Lewczuk, P. and others}, title = {{Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type}}, journal = {Neurobiology of aging}, year = {2015}, doi = {10.1016/j.neurobiolaging.2014.10.031}, pmid = {25435336}, url = {https://doi.org/10.1016/j.neurobiolaging.2014.10.031} } @article{heneka2006-16452658, author = {Heneka, M. T. and Ramanathan, M. and Jacobs, A. H. and Dumitrescu-Ozimek, L. and Bilkei-Gorzo, A. and Debeir, T. and Sastre, M. and Galldiks, N. and others}, title = {{Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2006}, doi = {10.1523/jneurosci.4236-05.2006}, pmid = {16452658}, url = {https://doi.org/10.1523/jneurosci.4236-05.2006} } @article{boschqueralt2021-33619376, author = {Bosch-Queralt, M. and Cantuti-Castelvetri, L. and Damkou, A. and Schifferer, M. and Schlepckow, K. and Alexopoulos, I. and Lütjohann, D. and Klose, C. and others}, title = {{Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination}}, journal = {Nature metabolism}, year = {2021}, doi = {10.1038/s42255-021-00341-7}, pmid = {33619376}, url = {https://doi.org/10.1038/s42255-021-00341-7} } @article{hammes2021-32620704, author = {Hammes, J. and Bischof, G. N. and Bohn, K. P. and Ö, Onur and Schneider, A. and Fliessbach, K. and Hönig, M. C. and Jessen, F. and others}, title = {{One-Stop Shop: 18F-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases}}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year = {2021}, doi = {10.2967/jnumed.120.244061}, pmid = {32620704}, url = {https://doi.org/10.2967/jnumed.120.244061} } @article{hampel2011-22137045, author = {Hampel, H. and Prvulovic, D. and Teipel, S. and Jessen, F. and Luckhaus, C. and Frölich, L. and Riepe, M. W. and Dodel, R. and others}, title = {{The future of Alzheimer's disease: the next 10 years}}, journal = {Progress in neurobiology}, year = {2011}, doi = {10.1016/j.pneurobio.2011.11.008}, pmid = {22137045}, url = {https://doi.org/10.1016/j.pneurobio.2011.11.008} } @article{brandao2025-39813317, author = {Brandão, Wesley Nogueira and Jain, Nimansha and Yin, Zhuoran and Kleemann, Kilian L. and Carpenter, Madison and Bao, Xin and Serrano, Javier Remolina and Tycksen, Eric and others}, title = {{Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy}}, journal = {Science Translational Medicine}, year = {2025}, doi = {10.1126/scitranslmed.adk3690}, pmid = {39813317}, url = {https://doi.org/10.1126/scitranslmed.adk3690} } @article{chalermpalanupap2013-23634965, author = {Chalermpalanupap, T. and Kinkead, B. and Hu, W. T. and Kummer, M. P. and Hammerschmidt, T. and Heneka, M. T. and Weinshenker, D. and Levey, A. I.}, title = {{Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2013}, doi = {10.1186/alzrt175}, pmid = {23634965}, url = {https://doi.org/10.1186/alzrt175} } @article{thal2003-14692704, author = {Thal, D. R. and Ghebremedhin, E. and Orantes, M. and Wiestler, O. D.}, title = {{Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline}}, journal = {Journal of neuropathology and experimental neurology}, year = {2003}, doi = {10.1093/jnen/62.12.1287}, pmid = {14692704}, url = {https://doi.org/10.1093/jnen/62.12.1287} } @article{sandhoff2013-23785136, author = {Sandhoff, K. and Harzer, K.}, title = {{Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2013}, doi = {10.1523/jneurosci.0822-13.2013}, pmid = {23785136}, url = {https://doi.org/10.1523/jneurosci.0822-13.2013} } @article{leone2025-40712373, author = {Leone, Riccardo and Kobeleva, Xenia}, title = {{White matter hyperintensities contribute to early cortical thinning in addition to tau in aging}}, journal = {Neurobiology of Aging}, year = {2025}, doi = {10.1016/j.neurobiolaging.2025.07.007}, pmid = {40712373}, url = {https://doi.org/10.1016/j.neurobiolaging.2025.07.007} } @article{hooijmans2007-17720508, author = {Hooijmans, C. R. and Rutters, F. and Dederen, P. J. and Gambarota, G. and Veltien, A. and van Groen, T. and Broersen, L. M. and Lütjohann, D. and others}, title = {{Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)}}, journal = {Neurobiology of disease}, year = {2007}, doi = {10.1016/j.nbd.2007.06.007}, pmid = {17720508}, url = {https://doi.org/10.1016/j.nbd.2007.06.007} } @article{golubnitschaja2022-36415625, author = {Golubnitschaja, O. and Potuznik, P. and Polivka, J. and Pesta, M. and Kaverina, O. and Pieper, C. C. and Kropp, M. and Thumann, G. and others}, title = {{Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach}}, journal = {The EPMA journal}, year = {2022}, doi = {10.1007/s13167-022-00307-z}, pmid = {36415625}, url = {https://doi.org/10.1007/s13167-022-00307-z} } @article{schubert1991-1786532, author = {Schubert, W. and Prior, R. and Weidemann, A. and Dircksen, H. and Multhaup, G. and Masters, C. L. and Beyreuther, K.}, title = {{Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites}}, journal = {Brain research}, year = {1991}, doi = {10.1016/0006-8993(91)91532-6}, pmid = {1786532}, url = {https://doi.org/10.1016/0006-8993(91)91532-6} } @article{neumann2007-17239445, author = {Neumann, H. and Takahashi, K.}, title = {{Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis}}, journal = {Journal of neuroimmunology}, year = {2007}, doi = {10.1016/j.jneuroim.2006.11.032}, pmid = {17239445}, url = {https://doi.org/10.1016/j.jneuroim.2006.11.032} } @article{rakusa2025-39966759, author = {Rakuša, Elena and Reinke, Constantin and Doblhammer, Gabriele and Radbruch, Lukas and Schmid, Matthias C. and Welchowski, Thomas}, title = {{Dementia as a predictor of palliative care: Uncovering patient patterns based on German claims data}}, journal = {BMC Palliative Care}, year = {2025}, doi = {10.1186/s12904-025-01672-y}, pmid = {39966759}, url = {https://doi.org/10.1186/s12904-025-01672-y} } @article{heneka2001-11556547, author = {Heneka, M. T. and Wiesinger, H. and Dumitrescu-Ozimek, L. and Riederer, P. and Feinstein, D. L. and Klockgether, T.}, title = {{Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease}}, journal = {Journal of neuropathology and experimental neurology}, year = {2001}, doi = {10.1093/jnen/60.9.906}, pmid = {11556547}, url = {https://doi.org/10.1093/jnen/60.9.906} } @article{pietrzik2010-20608755, author = {Pietrzik, K. and Bailey, L. and Shane, B.}, title = {{Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics}}, journal = {Clinical pharmacokinetics}, year = {2010}, doi = {10.2165/11532990-000000000-00000}, pmid = {20608755}, url = {https://doi.org/10.2165/11532990-000000000-00000} } @article{tamboli2010-20876579, author = {Tamboli, I. Y. and Barth, E. and Christian, L. and Siepmann, M. and Kumar, S. and Singh, S. and Tolksdorf, K. and Heneka, M. T. and others}, title = {{Statins promote the degradation of extracellular amyloid beta-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion}}, journal = {The Journal of biological chemistry}, year = {2010}, doi = {10.1074/jbc.m110.149468}, pmid = {20876579}, url = {https://doi.org/10.1074/jbc.m110.149468} } @article{melchior2010-20640189, author = {Melchior, B. and Garcia, A. E. and Hsiung, B. K. and Lo, K. M. and Doose, J. M. and Thrash, J. C. and Stalder, A. K. and Staufenbiel, M. and others}, title = {{Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease}}, journal = {ASN neuro}, year = {2010}, doi = {10.1042/an20100010}, pmid = {20640189}, url = {https://doi.org/10.1042/an20100010} } @article{brosseron2021-32894885, author = {Brosseron, F. and Kleemann, K. and Kolbe, C. C. and Santarelli, F. and Castro-Gomez, S. and Tacik, P. and Latz, E. and Jessen, F. and others}, title = {{Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation}}, journal = {Journal of neurochemistry}, year = {2021}, doi = {10.1111/jnc.15175}, pmid = {32894885}, url = {https://doi.org/10.1111/jnc.15175} } @article{pir2025-40891506, author = {Pir, Ghulam Jeelani and Buddenkotte, Joerg and Alam, Majid Ali and Own, Ahmed M. and Eck, Randall J. and Kraemer, Brian C. and Mandelkow�, Eckhard and Steinhoff, Martin S.}, title = {{TDP ‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models}}, journal = {FEBS Journal}, year = {2025}, doi = {10.1111/febs.70239}, pmid = {40891506}, url = {https://doi.org/10.1111/febs.70239} } @article{hooijmans2009-19130883, author = {Hooijmans, C. R. and Van der Zee, C. E. and Dederen, P. J. and Brouwer, K. M. and Reijmer, Y. D. and van Groen, T. and Broersen, L. M. and Lütjohann, D. and others}, title = {{DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice}}, journal = {Neurobiology of disease}, year = {2009}, doi = {10.1016/j.nbd.2008.12.002}, pmid = {19130883}, url = {https://doi.org/10.1016/j.nbd.2008.12.002} } @article{venkataramani2010-20145244, author = {Venkataramani, V. and Rossner, C. and Iffland, L. and Schweyer, S. and Tamboli, I. Y. and Walter, J. and Wirths, O. and Bayer, T. A.}, title = {{Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein}}, journal = {The Journal of biological chemistry}, year = {2010}, doi = {10.1074/jbc.m109.057836}, pmid = {20145244}, url = {https://doi.org/10.1074/jbc.m109.057836} } @article{walter2016-26694609, author = {Walter, J.}, title = {{The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases}}, journal = {The Journal of biological chemistry}, year = {2016}, doi = {10.1074/jbc.r115.704981}, pmid = {26694609}, url = {https://doi.org/10.1074/jbc.r115.704981} } @article{mukherjee2019-30733664, author = {Mukherjee, S. and Klaus, C. and Pricop-Jeckstadt, M. and Miller, J. A. and Struebing, F. L.}, title = {{A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks}}, journal = {Frontiers in neuroscience}, year = {2019}, doi = {10.3389/fnins.2019.00002}, pmid = {30733664}, url = {https://doi.org/10.3389/fnins.2019.00002} } @article{aborageh2025-40360514, author = {Aborageh, Mohamed and Hähnel, Tom and Conde, Patricia Martins and Klucken, Jochen and Fröhlich, Holger}, title = {{Predicting dementia in people with Parkinson’s disease}}, journal = {npj Parkinson s Disease}, year = {2025}, doi = {10.1038/s41531-025-00983-4}, pmid = {40360514}, url = {https://doi.org/10.1038/s41531-025-00983-4} } @article{lutjohann2002-12091492, author = {Lütjohann, D. and Brzezinka, A. and Barth, E. and Abramowski, D. and Staufenbiel, M. and von Bergmann, K. and Beyreuther, K. and Multhaup, G. and others}, title = {{Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain}}, journal = {Journal of lipid research}, year = {2002}, doi = {10.1194/jlr.m200071-jlr200}, pmid = {12091492}, url = {https://doi.org/10.1194/jlr.m200071-jlr200} } @article{tamboli2005-15923191, author = {Tamboli, I. Y. and Prager, K. and Barth, E. and Heneka, M. and Sandhoff, K. and Walter, J.}, title = {{Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m414525200}, pmid = {15923191}, url = {https://doi.org/10.1074/jbc.m414525200} } @article{linnartz2013-22615186, author = {Linnartz, B. and Neumann, H.}, title = {{Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx}}, journal = {Glia}, year = {2013}, doi = {10.1002/glia.22359}, pmid = {22615186}, url = {https://doi.org/10.1002/glia.22359} } @article{linnartz2010-20721346, author = {Linnartz, B. and Wang, Y. and Neumann, H.}, title = {{Microglial immunoreceptor tyrosine-based activation and inhibition motif signaling in neuroinflammation}}, journal = {International journal of Alzheimer's disease}, year = {2010}, doi = {10.4061/2010/587463}, pmid = {20721346}, url = {https://doi.org/10.4061/2010/587463} } @article{zarea2026-42215639, author = {Zaréa, Aline and Cassinari, Kévin and Lecoquierre, François and Quenez, Olivier and Charbonnier, Camille and Schramm, Catherine and Lacour, Morgane and Rousseau, Stéphane and others}, title = {{Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios}}, journal = {Molecular Psychiatry}, year = {2026}, doi = {10.1038/s41380-026-03665-6}, pmid = {42215639}, url = {https://doi.org/10.1038/s41380-026-03665-6} } @article{bartels2025-40847320, author = {Bartels, Claudia and Chen, J. and Belz, Michael K. and Yakupov, Renat and Düzel, Emrah and Glanz, Wenzel and Lüsebrink, Falk and Dechent, Peter and others}, title = {{Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia}}, journal = {Alzheimer s Research \& Therapy}, year = {2025}, doi = {10.1186/s13195-025-01833-4}, pmid = {40847320}, url = {https://doi.org/10.1186/s13195-025-01833-4} } @article{utter2008-18716559, author = {Utter, S. and Tamboli, I. Y. and Walter, J. and Upadhaya, A. R. and Birkenmeier, G. and Pietrzik, C. U. and Ghebremedhin, E. and Thal, D. R.}, title = {{Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes}}, journal = {Journal of neuropathology and experimental neurology}, year = {2008}, doi = {10.1097/nen.0b013e3181836a71}, pmid = {18716559}, url = {https://doi.org/10.1097/nen.0b013e3181836a71} } @article{villacampa2025-40387894, author = {Villacampa, Nàdia and Sarlus, Heela and Martorell, Paula and Bhalla, Khushbu and Castro‐Gomez, Sergio and Vieira-Saecker, Ana Maria Menezes and Slutzkin, Ilya and Händler, Kristian and others}, title = {{Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease}}, journal = {ASN NEURO}, year = {2025}, doi = {10.1080/17590914.2025.2506406}, pmid = {40387894}, url = {https://doi.org/10.1080/17590914.2025.2506406} } @article{kapadia2026-42681024, author = {Kapadia, Akshay and Schuhmann, Fabian and Daşkın, Ezgi and Walter, Jochen and Lindahl, Isabell and Rahmani, Neda and Morrema, Tjado H. J. and Rozemüller, Annemieke J.M. and others}, title = {{Presynaptic accumulation of APP-CTFβ may contribute to synaptic dysfunction in Alzheimer’s disease}}, journal = {The EMBO Journal}, year = {2026}, doi = {10.1038/s44318-026-00899-6}, pmid = {42681024}, url = {https://doi.org/10.1038/s44318-026-00899-6} } @article{keeney2013-23027708, author = {Keeney, J. T. and Swomley, A. M. and Förster, S. and Harris, J. L. and Sultana, R. and Butterfield, D. A.}, title = {{Apolipoprotein A-I: insights from redox proteomics for its role in neurodegeneration}}, journal = {Proteomics. Clinical applications}, year = {2013}, doi = {10.1002/prca.201200087}, pmid = {23027708}, url = {https://doi.org/10.1002/prca.201200087} } @article{labudova1999-10210286, author = {Labudova, O. and Cairns, N. and Koeck, T. and Kitzmueller, E. and Rink, H. and Lubec, G.}, title = {{Thyroid stimulating hormone-receptor overexpression in brain of patients with Down syndrome and Alzheimer's disease}}, journal = {Life sciences}, year = {1999}, doi = {10.1016/s0024-3205(99)00030-2}, pmid = {10210286}, url = {https://doi.org/10.1016/s0024-3205(99)00030-2} } @article{heide2017-28318110, author = {Heide, Loehlein Fier and Dmitry, Prokopenko and Julian, Hecker and Cho Michael, H. and Silverman Edwin, K. and Weiss Scott, T. and Tanzi Rudolph, E. and Christoph, Lange}, title = {{On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows}}, journal = {Genetic epidemiology}, year = {2017}, doi = {10.1002/gepi.22040}, pmid = {28318110}, url = {https://doi.org/10.1002/gepi.22040} } @article{schaper2025-41429419, author = {Schäper, Philipp and Hanke, Alexander and Jonas, Stephan and Nissen, Leon and Reimer, Lara Marie and Schweizer, Florian and Wagner, Michael and Rolke, Kristin and others}, title = {{Usability of a Tablet-Based Cognitive Assessment Administered by Medical Assistants in General Practice: Implementation Study}}, journal = {JMIR Formative Research}, year = {2025}, doi = {10.2196/76010}, pmid = {41429419}, url = {https://doi.org/10.2196/76010} } @article{onuroezguer2022-35858613, author = {Onur Oezguer, A. and Claus, Wolff-Menzler and von Arnim Christine A, F. and Frank, Jessen and Fink Gereon, R. and Jens, Wiltfang and Christoph, Laske and Anja, Schneider and others}, title = {{[The Cost of Early Diagnosis of Cognitive Decline in German Memory Clinics]}}, journal = {Fortschritte der Neurologie-Psychiatrie}, year = {2022}, doi = {10.1055/a-1871-9889}, pmid = {35858613}, url = {https://doi.org/10.1055/a-1871-9889} } @article{skjaerbaek2026-ad526bca, author = {Skjaerbaek, C. and Damgaard, A. T. and Bertelsen, N. B. and Lillethorup, T. P. and Horsager, J. and Lowe, V. and Andersen, N. H. and Terkelsen and others}, title = {{Self-applied single-channel mastoid ExG for fully automated detection of REM sleep behaviour disorder}}, journal = {medRxiv (preprint)}, year = {2026}, doi = {10.64898/2026.08.14.26360475}, url = {https://doi.org/10.64898/2026.08.14.26360475} } @article{legrand2026-1c507e85, author = {Le Grand, Q. and Koch, A. and Imtiaz, M.-A. and Maier, G. and Talevi, V. and Liu, D. and Aziz, N. A. and Breteler and others}, title = {{Diffusion kurtosis imaging (gen)omics unravels mechanisms of cerebral small vessel disease}}, journal = {medRxiv (preprint)}, year = {2026}, doi = {10.64898/2026.08.12.26360241}, url = {https://doi.org/10.64898/2026.08.12.26360241} } @article{kuhn2026-ad82dff0, author = {Kuhn, E. and Antopoulos, G. and Kleineidam, L. and Stark, M. and Roeske, S. and Hoffstaedter, F. and Waite, L. and Peters and others}, title = {{MRI-derived brain aging trajectories across the Alzheimer's continuum: links to cognition, pathology and lifestyle risk factors}}, journal = {medRxiv (preprint)}, year = {2026}, doi = {10.64898/2026.08.19.26360525}, url = {https://doi.org/10.64898/2026.08.19.26360525} }