% alzhub.org library filter % Source: https://alzhub.org/research?institution=I1283280774 % 400 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{barnes2023-37466280, author = {Barnes, L. L. and Dhana, K. and Liu, X. and Carey, V. J. and Ventrelle, J. and Johnson, K. and others}, title = {{Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons}}, journal = {New England Journal of Medicine}, year = {2023}, doi = {10.1056/NEJMoa2302368}, pmid = {37466280}, url = {https://doi.org/10.1056/NEJMoa2302368} } @article{salloway2014-24450891, author = {Salloway, S. and Sperling, R. and Fox, N. C. and Blennow, K. and Klunk, W. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others}, title = {{Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2014}, doi = {10.1056/nejmoa1304839}, pmid = {24450891}, url = {https://doi.org/10.1056/nejmoa1304839} } @article{zimmer2025-40063015, author = {Zimmer, J. A. and Ardayfio, P. and Wang, H. and Khanna, R. and Evans, C. D. and Lu, M. and Sparks, J. and Andersen, S. and Lauzon, S. and Nery, E. S. M. and others}, title = {{Amyloid-Related Imaging Abnormalities With Donanemab in Early Symptomatic Alzheimer Disease: Secondary Analysis of the TRAILBLAZER-ALZ and ALZ 2 Randomized Clinical Trials}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.0065}, pmid = {40063015}, url = {https://doi.org/10.1001/jamaneurol.2025.0065} } @article{naj2011-21460841, author = {Naj, A. C. and Jun, G. and Beecham, G. W. and Wang, L. S. and Vardarajan, B. N. and Buros, J. and Gallins, P. J. and Buxbaum, J. D. and others}, title = {{Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease}}, journal = {Nature genetics}, year = {2011}, doi = {10.1038/ng.801}, pmid = {21460841}, url = {https://doi.org/10.1038/ng.801} } @article{sims2017-28714976, author = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others}, title = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}}, journal = {Nature genetics}, year = {2017}, doi = {10.1038/ng.3916}, pmid = {28714976}, url = {https://doi.org/10.1038/ng.3916} } @article{ostrowitzki2022-36121669, author = {Ostrowitzki, S. and Bittner, T. and Sink, K. M. and Mackey, H. and Rabe, C. and Honig, L. S. and Cassetta, E. and Woodward, M. and others}, title = {{Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.2909}, pmid = {36121669}, url = {https://doi.org/10.1001/jamaneurol.2022.2909} } @article{moayyedi2019-31152740, author = {Moayyedi, P. and Eikelboom, J. W. and Bosch, J. and Connolly, S. J. and Dyal, L. and Shestakovska, O. and Leong, D. and Anand, S. S. and others}, title = {{Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin}}, journal = {Gastroenterology}, year = {2019}, doi = {10.1053/j.gastro.2019.05.056}, pmid = {31152740}, url = {https://doi.org/10.1053/j.gastro.2019.05.056} } @article{cummings2025-39780249, author = {Cummings, J. L. and Atri, A. and Feldman, H. H. and Hansson, O. and Sano, M. and Knop, F. K. and Johannsen, P. and León, T. and others}, title = {{evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-024-01666-7}, pmid = {39780249}, url = {https://doi.org/10.1186/s13195-024-01666-7} } @article{manson2013-24084921, author = {Manson, J. E. and Chlebowski, R. T. and Stefanick, M. L. and Aragaki, A. K. and Rossouw, J. E. and Prentice, R. L. and Anderson, G. and Howard, B. V. and others}, title = {{Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials}}, journal = {JAMA}, year = {2013}, doi = {10.1001/jama.2013.278040}, pmid = {24084921}, url = {https://doi.org/10.1001/jama.2013.278040} } @article{pase2023-37462968, author = {Pase, M. P. and Harrison, S. and Misialek, JR. and Kline, C. E. and Cavuoto, M. and Baril, A. A. and Yiallourou, S. and Bisson, A. and others}, title = {{Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.25152}, pmid = {37462968}, url = {https://doi.org/10.1001/jamanetworkopen.2023.25152} } @article{jun2016-25778476, author = {Jun, G. and Ibrahim-Verbaas, C. A. and Vronskaya, M. and Lambert, J. C. and Chung, J. and Naj, A. C. and Kunkle, B. W. and Wang, L. S. and others}, title = {{A novel Alzheimer disease locus located near the gene encoding tau protein}}, journal = {Molecular psychiatry}, year = {2016}, doi = {10.1038/mp.2015.23}, pmid = {25778476}, url = {https://doi.org/10.1038/mp.2015.23} } @article{lewis2025-39982143, author = {Lewis, Kimberley A. and Balas, Michele C. and Stollings, Joanna L. and McNett, Molly and Girard, Timothy D. and Chanques, Gérald and Kho, Michelle E. and Pandharipande, Pratik P. and others}, title = {{A Focused Update to the Clinical Practice Guidelines for the Prevention and Management of Pain, Anxiety, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU}}, journal = {Critical Care Medicine}, year = {2025}, doi = {10.1097/ccm.0000000000006574}, pmid = {39982143}, url = {https://doi.org/10.1097/ccm.0000000000006574} } @article{bateman2012-22784036, author = {Bateman, Randall John and Xiong, Chengjie and Benzinger, Tammie L.S. and Fagan, Anne M. and Goate, Alison and Fox, Nick C. and Marcus, Daniel S. and Cairns, Nigel J. and others}, title = {{Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease}}, journal = {New England Journal of Medicine}, year = {2012}, doi = {10.1056/nejmoa1202753}, pmid = {22784036}, url = {https://doi.org/10.1056/nejmoa1202753} } @article{honig2024-38730496, author = {Honig, L. S. and Sabbagh, M. N. and van Dyck, C. H. and Sperling, R. A. and Hersch, S. and Matta, A. and Giorgi, L. and Gee, M. and others}, title = {{Updated safety results from phase 3 lecanemab study in early Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01441-8}, pmid = {38730496}, url = {https://doi.org/10.1186/s13195-024-01441-8} } @article{atri2018-29318278, author = {Atri, A. and Frölich, L. and Ballard, C. and Tariot, P. N. and Molinuevo, J. L. and Boneva, N. and Windfeld, K. and Raket, L. L. and others}, title = {{Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials}}, journal = {JAMA}, year = {2018}, doi = {10.1001/jama.2017.20373}, pmid = {29318278}, url = {https://doi.org/10.1001/jama.2017.20373} } @article{hanseeuw2019-31157827, author = {Hanseeuw, B. J. and Betensky, R. A. and Jacobs, H. I. L. and Schultz, A. P. and Sepulcre, J. and Becker, J. A. and Cosio, D. M. O. and Farrell, M. and others}, title = {{Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2019.1424}, pmid = {31157827}, url = {https://doi.org/10.1001/jamaneurol.2019.1424} } @article{coughlan2025-40029638, author = {Coughlan, G. T. and Klinger, H. M. and Boyle, R. and Betthauser, T. J. and Binette, A. P. and Christenson, L. and Chadwick, T. and Hansson, O. and others}, title = {{Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis}}, journal = {JAMA neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.0013}, pmid = {40029638}, url = {https://doi.org/10.1001/jamaneurol.2025.0013} } @article{ossenkoppele2022-36357681, author = {Ossenkoppele, R. and Pichet Binette, A. and Groot, C. and Smith, R. and Strandberg, O. and Palmqvist, S. and Stomrud, E. and Tideman, P. and others}, title = {{Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline}}, journal = {Nature medicine}, year = {2022}, doi = {10.1038/s41591-022-02049-x}, pmid = {36357681}, url = {https://doi.org/10.1038/s41591-022-02049-x} } @article{moscoso2025-40522652, author = {Moscoso, Alexis and Heeman, Fiona and Raghavan, Sheelakumari and Costoya‐Sánchez, Alejandro and van Essen, Martijn and Mainta, Ismini and Camacho, Valle and Rodríguez-Fonseca, Omar Darío and others}, title = {{Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity}}, journal = {JAMA}, year = {2025}, doi = {10.1001/jama.2025.7817}, pmid = {40522652}, url = {https://doi.org/10.1001/jama.2025.7817} } @article{baker2025-40720610, author = {Baker, L. D. and Espeland, M. A. and Whitmer, R. A. and Snyder, H. M. and Leng, X. and Lovato, L. and Papp, K. V. and Yu, M. and others}, title = {{Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial}}, journal = {JAMA}, year = {2025}, doi = {10.1001/jama.2025.12923}, pmid = {40720610}, url = {https://doi.org/10.1001/jama.2025.12923} } @article{sherva2023-36543923, author = {Sherva, R. and Zhang, R. and Sahelijo, N. and Jun, G. and Anglin, T. and Chanfreau, C. and Cho, K. and Fonda, JR. and others}, title = {{African ancestry GWAS of dementia in a large military cohort identifies significant risk loci}}, journal = {Molecular psychiatry}, year = {2023}, doi = {10.1038/s41380-022-01890-3}, pmid = {36543923}, url = {https://doi.org/10.1038/s41380-022-01890-3} } @article{mattssoncarlgren2020-33068398, author = {Mattsson-Carlgren, N. and Janelidze, S. and Palmqvist, S. and Cullen, N. and Svenningsson, A. L. and Strandberg, O. and Mengel, D. and Walsh, D. M. and others}, title = {{Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2020}, doi = {10.1093/brain/awaa286}, pmid = {33068398}, url = {https://doi.org/10.1093/brain/awaa286} } @article{rabinovici2025-39776249, author = {Rabinovici, G. D. and Knopman, D. S. and Arbizu, J. and Benzinger, T. L. S. and Donohoe, K. J. and Hansson, O. and Herscovitch, P. and Kuo, P. H. and Lingler, J. H. and Minoshima, S. and others}, title = {{Updated appropriate use criteria for amyloid and tau PET: A report from the Alzheimer's Association and Society for Nuclear Medicine and Molecular Imaging Workgroup}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.14338}, pmid = {39776249}, url = {https://doi.org/10.1002/alz.14338} } @article{sperling2024-39044488, author = {Sperling, R. A. and Donohue, M. C. and Rissman, R. A. and Johnson, K. A. and Rentz, D. M. and Grill, J. D. and Heidebrink, J. L. and Jenkins, C. and others}, title = {{Amyloid and Tau Prediction of Cognitive and Functional Decline in Unimpaired Older Individuals: Longitudinal Data from the A4 and LEARN Studies}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.122}, pmid = {39044488}, url = {https://doi.org/10.14283/jpad.2024.122} } @article{wagemann2024-38683602, author = {Wagemann, O. and Liu, H. and Wang, G. and Shi, X. and Bittner, T. and Scelsi, M. A. and Farlow, M. R. and Clifford, D. B. and others}, title = {{Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.0991}, pmid = {38683602}, url = {https://doi.org/10.1001/jamaneurol.2024.0991} } @article{salloway2009-19923550, author = {Salloway, S. and Sperling, R. and Gilman, S. and Fox, N. C. and Blennow, K. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others}, title = {{A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181c67808}, pmid = {19923550}, url = {https://doi.org/10.1212/wnl.0b013e3181c67808} } @article{grill2020-32777010, author = {Grill, J. D. and Raman, R. and Ernstrom, K. and Sultzer, D. L. and Burns, J. M. and Donohue, M. C. and Johnson, K. A. and Aisen, P. S. and others}, title = {{Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.2734}, pmid = {32777010}, url = {https://doi.org/10.1001/jamaneurol.2020.2734} } @article{marcantonio2001-11380742, author = {Marcantonio, E. R. and Flacker, J. M. and Wright, R. J. and Resnick, N. M.}, title = {{Reducing delirium after hip fracture: a randomized trial}}, journal = {Journal of the American Geriatrics Society}, year = {2001}, doi = {10.1046/j.1532-5415.2001.49108.x}, pmid = {11380742}, url = {https://doi.org/10.1046/j.1532-5415.2001.49108.x} } @article{zhang2026-41661604, author = {Zhang, Y. and Liu, Y. and Li, Y. and Gu, X. and Kang, J. H. and others}, title = {{Coffee and Tea Intake, Dementia Risk, and Cognitive Function}}, journal = {JAMA}, year = {2026}, doi = {10.1001/jama.2025.27259}, pmid = {41661604}, url = {https://doi.org/10.1001/jama.2025.27259} } @article{leguen2023-36809323, author = {Le Guen, Y. and Raulin, A. C. and Logue, M. W. and Sherva, R. and Belloy, M. E. and Eger, S. J. and Chen, A. and Kennedy, G. and Kuchenbecker, L. and O'Leary, J. P. and Zhang, R. and Merritt, V. C. and others}, title = {{Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease}}, journal = {JAMA}, year = {2023}, doi = {10.1001/jama.2023.0268}, pmid = {36809323}, url = {https://doi.org/10.1001/jama.2023.0268} } @article{chew2015-26305649, author = {Chew, E. Y. and Clemons, T. E. and Agrón, E. and Launer, L. J. and Grodstein, F. and Bernstein, P. S.}, title = {{Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial}}, journal = {JAMA}, year = {2015}, doi = {10.1001/jama.2015.9677}, pmid = {26305649}, url = {https://doi.org/10.1001/jama.2015.9677} } @article{sperling2021-33464300, author = {Sperling, R. and Henley, D. and Aisen, P. S. and Raman, R. and Donohue, M. C. and Ernstrom, K. and Rafii, M. S. and Streffer, J. and others}, title = {{Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial}}, journal = {JAMA neurology}, year = {2021}, doi = {10.1001/jamaneurol.2020.4857}, pmid = {33464300}, url = {https://doi.org/10.1001/jamaneurol.2020.4857} } @article{donohue2017-28609533, author = {Donohue, M. C. and Sperling, R. A. and Petersen, R. and Sun, C. K. and Weiner, M. W. and Aisen, P. S. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons}}, journal = {JAMA}, year = {2017}, doi = {10.1001/jama.2017.6669}, pmid = {28609533}, url = {https://doi.org/10.1001/jama.2017.6669} } @article{postuma2019-30789229, author = {Postuma, R. B. and Iranzo, A. and Hu, M. and Högl, B. and Boeve, B. F. and Manni, R. and Oertel, W. H. and Arnulf, I. and others}, title = {{Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study}}, journal = {Brain : a journal of neurology}, year = {2019}, doi = {10.1093/brain/awz030}, pmid = {30789229}, url = {https://doi.org/10.1093/brain/awz030} } @article{rhee2019-30768188, author = {Rhee, C. and Jones, T. M. and Hamad, Y. and Pande, A. and Varon, J. and O'Brien, C. and Anderson, D. J. and Warren, D. K. and others}, title = {{Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2018.7571}, pmid = {30768188}, url = {https://doi.org/10.1001/jamanetworkopen.2018.7571} } @article{quiroz2024-38899694, author = {Quiroz, Y. T. and Aguillon, D. and Aguirre-Acevedo, D. C. and Vasquez, D. and Zuluaga, Y. and Baena, A. Y. and Madrigal, L. and Hincapié, L. and Sanchez, J. S. and Langella, S. and Posada-Duque, R. and Littau, J. L. and others}, title = {{APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease}}, journal = {New England Journal of Medicine}, year = {2024}, doi = {10.1056/NEJMoa2308583}, pmid = {38899694}, url = {https://doi.org/10.1056/NEJMoa2308583} } @article{cronje2023-37392405, author = {Cronjé, H. T. and Liu, X. and Odden, M. C. and Moseholm, K. F. and Seshadri, S. and Satizabal, C. L. and Lopez, O. L. and Bis, J. C. and Djoussé, L. and Fohner, A. E. and Psaty, B. M. and Tracy, R. P. and others}, title = {{Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study}}, journal = {Alzheimer's \& Dementia}, year = {2023}, doi = {10.1002/alz.13367}, pmid = {37392405}, url = {https://doi.org/10.1002/alz.13367} } @article{naj2014-25199842, author = {Naj, A. C. and Jun, G. and Reitz, C. and Kunkle, B. W. and Perry, W. and Park, Y. S. and Beecham, G. W. and Rajbhandary, R. A. and others}, title = {{Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.1491}, pmid = {25199842}, url = {https://doi.org/10.1001/jamaneurol.2014.1491} } @article{volandes2023-37695586, author = {Volandes, A. E. and Zupanc, S. N. and Lakin, JR. and Cabral, H. J. and Burns, E. A. and Carney, M. T. and Lopez, S. and Itty, J. and others}, title = {{Video Intervention and Goals-of-Care Documentation in Hospitalized Older Adults: The VIDEO-PCE Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.32556}, pmid = {37695586}, url = {https://doi.org/10.1001/jamanetworkopen.2023.32556} } @article{wang2005-16319382, author = {Wang, P. S. and Schneeweiss, S. and Avorn, J. and Fischer, M. A. and Mogun, H. and Solomon, D. H. and Brookhart, M. A.}, title = {{Risk of death in elderly users of conventional vs. atypical antipsychotic medications}}, journal = {The New England journal of medicine}, year = {2005}, doi = {10.1056/nejmoa052827}, pmid = {16319382}, url = {https://doi.org/10.1056/nejmoa052827} } @article{wang2023-36848126, author = {Wang, X. and Ma, H. and Li, X. and Heianza, Y. and Manson, J. E. and Franco, O. H. and Qi, L.}, title = {{Association of Cardiovascular Health With Life Expectancy Free of Cardiovascular Disease, Diabetes, Cancer, and Dementia in UK Adults}}, journal = {JAMA internal medicine}, year = {2023}, doi = {10.1001/jamainternmed.2023.0015}, pmid = {36848126}, url = {https://doi.org/10.1001/jamainternmed.2023.0015} } @article{sun2026-41854616, author = {Sun, Haoqi and Milton, Sasha and Fang, Yi and Taha, Hash Brown and Shiju, Shreya and Thomas, Robert J and Ganglberger, Wolfgang and Pase, Matthew P and others}, title = {{Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis}}, journal = {JAMA network open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.1521}, pmid = {41854616}, url = {https://doi.org/10.1001/jamanetworkopen.2026.1521} } @article{raghavan2020-32568366, author = {Raghavan, N. S. and Dumitrescu, L. and Mormino, E. and Mahoney, E. R. and Lee, A. J. and Gao, Y. and Bilgel, M. and Goldstein, D. and others}, title = {{Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.1760}, pmid = {32568366}, url = {https://doi.org/10.1001/jamaneurol.2020.1760} } @article{hohman2018-29801024, author = {Hohman, T. J. and Dumitrescu, L. and Barnes, L. L. and Thambisetty, M. and Beecham, G. and Kunkle, B. and Gifford, K. A. and Bush, W. S. and others}, title = {{Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2018.0821}, pmid = {29801024}, url = {https://doi.org/10.1001/jamaneurol.2018.0821} } @article{xue2024-38965435, author = {Xue, C. and Kowshik, S. S. and Lteif, D. and Puducheri, S. and Jasodanand, V. H. and Zhou, O. T. and Walia, A. S. and Guney, O. B. and others}, title = {{AI-based differential diagnosis of dementia etiologies on multimodal data}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-03118-z}, pmid = {38965435}, url = {https://doi.org/10.1038/s41591-024-03118-z} } @article{parhizkar2019-30617257, author = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others}, title = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-018-0296-9}, pmid = {30617257}, url = {https://doi.org/10.1038/s41593-018-0296-9} } @article{roostaei2017-27021820, author = {Roostaei, T. and Nazeri, A. and Felsky, D. and De Jager, P. L. and Schneider, J. A. and Pollock, B. G. and Bennett, D. A. and Voineskos, A. N. and others}, title = {{Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2017}, doi = {10.1038/mp.2016.35}, pmid = {27021820}, url = {https://doi.org/10.1038/mp.2016.35} } @article{tessier2024-38709531, author = {Tessier, A. J. and Cortese, M. and Yuan, C. and Bjornevik, K. and Ascherio, A. and Wang, D. D. and Chavarro, J. E. and Stampfer, M. J. and Hu, F. B. and Willett, W. C. and others}, title = {{Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death}}, journal = {JAMA Network Open}, year = {2024}, doi = {10.1001/jamanetworkopen.2024.10021}, pmid = {38709531}, url = {https://doi.org/10.1001/jamanetworkopen.2024.10021} } @article{atri2024-39713942, author = {Atri, A. and Dickerson, B. C. and Clevenger, C. and Karlawish, J. and Knopman, D. and Lin, P. J. and Norman, M. and Onyike, C. and Sano, M. and Scanland, S. and others}, title = {{Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD): Executive summary of recommendations for primary care}}, journal = {Alzheimer's \& Dementia}, year = {2024}, doi = {10.1002/alz.14333}, pmid = {39713942}, url = {https://doi.org/10.1002/alz.14333} } @article{sargurupremraj2020-33293549, author = {Sargurupremraj, M. and Suzuki, H. and Jian, X. and Sarnowski, C. and Evans, T. E. and Bis, J. C. and Eiriksdottir, G. and Sakaue, S. and others}, title = {{Cerebral small vessel disease genomics and its implications across the lifespan}}, journal = {Nature communications}, year = {2020}, doi = {10.1038/s41467-020-19111-2}, pmid = {33293549}, url = {https://doi.org/10.1038/s41467-020-19111-2} } @article{wayne2014-24383523, author = {Wayne, P. M. and Walsh, J. N. and Taylor-Piliae, R. E. and Wells, R. E. and Papp, K. V. and Donovan, N. J. and Yeh, G. Y.}, title = {{Effect of tai chi on cognitive performance in older adults: systematic review and meta-analysis}}, journal = {Journal of the American Geriatrics Society}, year = {2014}, doi = {10.1111/jgs.12611}, pmid = {24383523}, url = {https://doi.org/10.1111/jgs.12611} } @article{sperling2011-21514248, author = {Sperling, R. A. and Aisen, P. S. and Beckett, L. A. and Bennett, D. A. and Craft, S. and Fagan, A. M. and Iwatsubo, T. and Jack, C. R. and others}, title = {{Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2011}, doi = {10.1016/j.jalz.2011.03.003}, pmid = {21514248}, url = {https://doi.org/10.1016/j.jalz.2011.03.003} } @article{dube2019-31591557, author = {Dube, U. and Del-Aguila, J. L. and Li, Z. and Budde, J. P. and Jiang, S. and Hsu, S. and Ibanez, L. and Fernandez, M. V. and others}, title = {{An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-019-0501-5}, pmid = {31591557}, url = {https://doi.org/10.1038/s41593-019-0501-5} } @article{driver2012-22411920, author = {Driver, J. A. and Beiser, A. and Au, R. and Kreger, B. E. and Splansky, G. L. and Kurth, T. and Kiel, D. P. and Lu, K. P. and others}, title = {{Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study}}, journal = {BMJ (Clinical research ed.)}, year = {2012}, doi = {10.1136/bmj.e1442}, pmid = {22411920}, url = {https://doi.org/10.1136/bmj.e1442} } @article{younan2020-31746986, author = {Younan, D. and Petkus, A. J. and Widaman, K. F. and Wang, X. and Casanova, R. and Espeland, M. A. and Gatz, M. and Henderson, V. W. and others}, title = {{Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2020}, doi = {10.1093/brain/awz348}, pmid = {31746986}, url = {https://doi.org/10.1093/brain/awz348} } @article{szwedo2022-35106798, author = {Szwedo, A. A. and Dalen, I. and Pedersen, K. F. and Camacho, M. and Bäckström, D. and Forsgren, L. and Tzoulis, C. and Winder-Rhodes, S. and others}, title = {{GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2022}, doi = {10.1002/mds.28932}, pmid = {35106798}, url = {https://doi.org/10.1002/mds.28932} } @article{kwok2025-40094667, author = {Kwok, J. Y. Y. and Cheung, D. S. K. and Zarit, S. and Cheung, K. S. and Lau, B. H. P. and Lou, V. W. and Cheng, S. T. and Gallagher-Thompson, D. and Qian, M. and Chou, K. L.}, title = {{Multicomponent Intervention for Distressed Informal Caregivers of People With Dementia: A Randomized Clinical Trial}}, journal = {JAMA Network Open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.0069}, pmid = {40094667}, url = {https://doi.org/10.1001/jamanetworkopen.2025.0069} } @article{shadyab2026-41805953, author = {Shadyab, A. H. and Zhang, B. and LaCroix, A. Z. and Mielke, M. M. and Resnick, S. M. and Nguyen, S. and Ferrucci, L. and Libermann, T. A. and Ngo, L. and Casanova, R. and others}, title = {{Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.1295}, pmid = {41805953}, url = {https://doi.org/10.1001/jamanetworkopen.2026.1295} } @article{insel2025-40853684, author = {Insel, P. S. and Mattsson-Carlgren, N. and Langford, O. and Caruso, V. M. and Leuzy, A. and Young, C. B. and Boxer, A. and Aisen, P. S. and Sperling, R. A. and Mormino, E. C. and Donohue, M. C.}, title = {{Concurrent Changes in Plasma Phosphorylated Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.2974}, pmid = {40853684}, url = {https://doi.org/10.1001/jamaneurol.2025.2974} } @article{verhaaren2015-25663218, author = {Verhaaren, B. F. and Debette, S. and Bis, J. C. and Smith, J. A. and Ikram, M. K. and Adams, H. H. and Beecham, A. H. and Rajan, K. B. and others}, title = {{Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI}}, journal = {Circulation. Cardiovascular genetics}, year = {2015}, doi = {10.1161/circgenetics.114.000858}, pmid = {25663218}, url = {https://doi.org/10.1161/circgenetics.114.000858} } @article{salloway2011-21917766, author = {Salloway, S. and Sperling, R. and Keren, R. and Porsteinsson, A. P. and van Dyck, C. H. and Tariot, P. N. and Gilman, S. and Arnold, D. and others}, title = {{A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e3182309fa5}, pmid = {21917766}, url = {https://doi.org/10.1212/wnl.0b013e3182309fa5} } @article{grodstein2013-24490265, author = {Grodstein, F. and O'Brien, J. and Kang, J. H. and Dushkes, R. and Cook, N. R. and Okereke, O. and Manson, J. E. and Glynn, R. J. and others}, title = {{Long-term multivitamin supplementation and cognitive function in men: a randomized trial}}, journal = {Annals of internal medicine}, year = {2013}, doi = {10.7326/0003-4819-159-12-201312170-00006}, pmid = {24490265}, url = {https://doi.org/10.7326/0003-4819-159-12-201312170-00006} } @article{christensen2018-28726810, author = {Christensen, K. D. and Uhlmann, W. R. and Roberts, J. S. and Linnenbringer, E. and Whitehouse, P. J. and Royal, C. D. M. and Obisesan, T. O. and Cupples, L. A. and others}, title = {{A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone}}, journal = {Genetics in medicine : official journal of the American College of Medical Genetics}, year = {2018}, doi = {10.1038/gim.2017.103}, pmid = {28726810}, url = {https://doi.org/10.1038/gim.2017.103} } @article{rabin2018-29799986, author = {Rabin, J. S. and Schultz, A. P. and Hedden, T. and Viswanathan, A. and Marshall, G. A. and Kilpatrick, E. and Klein, H. and Buckley, R. F. and others}, title = {{Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2018.1123}, pmid = {29799986}, url = {https://doi.org/10.1001/jamaneurol.2018.1123} } @article{sanchez2021-33472953, author = {Sanchez, J. S. and Becker, J. A. and Jacobs, H. I. L. and Hanseeuw, B. J. and Jiang, S. and Schultz, A. P. and Properzi, M. J. and Katz, SR. and others}, title = {{The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography}}, journal = {Science translational medicine}, year = {2021}, doi = {10.1126/scitranslmed.abc0655}, pmid = {33472953}, url = {https://doi.org/10.1126/scitranslmed.abc0655} } @article{fortea2024-38710950, author = {Fortea, J. and Pegueroles, J. and Alcolea, D. and Belbin, O. and Dols-Icardo, O. and Vaqué-Alcázar, L. and Videla, L. and Gispert, J. D. and others}, title = {{APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-02931-w}, pmid = {38710950}, url = {https://doi.org/10.1038/s41591-024-02931-w} } @article{weiner2015-26073027, author = {Weiner, M. W. and Veitch, D. P. and Aisen, P. S. and Beckett, L. A. and Cairns, N. J. and Cedarbaum, J. and Green, R. C. and Harvey, D. and others}, title = {{2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2014.11.001}, pmid = {26073027}, url = {https://doi.org/10.1016/j.jalz.2014.11.001} } @article{ko2022-36399339, author = {Ko, Darae and Lin, Kueiyu Joshua and Bessette, Lily Gui and Lee, Su Been and Walkey, Allan J. and Cheng, Susan C. and Kim, Erin and Glynn, Robert J. and others}, title = {{Trends in Use of Oral Anticoagulants in Older Adults With Newly Diagnosed Atrial Fibrillation, 2010-2020}}, journal = {JAMA Network Open}, year = {2022}, doi = {10.1001/jamanetworkopen.2022.42964}, pmid = {36399339}, url = {https://doi.org/10.1001/jamanetworkopen.2022.42964} } @article{coughlan2026-41697669, author = {Coughlan, Gillian T and Ourry, Valentin and Townsend, Diana and Klinger, Hannah and Brown, Jane A and Cuppels, Madison and Betthauser, Tobey and Langhough, Rebecca and others}, title = {{Sex Differences in P-Tau217, Tau Aggregation, and Cognitive Decline}}, journal = {JAMA neurology}, year = {2026}, doi = {10.1001/jamaneurol.2025.5670}, pmid = {41697669}, url = {https://doi.org/10.1001/jamaneurol.2025.5670} } @article{sperling2020-32250387, author = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Sun, C. K. and Yaari, R. and Holdridge, K. and Siemers, E. and Johnson, K. A. and others}, title = {{Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.0387}, pmid = {32250387}, url = {https://doi.org/10.1001/jamaneurol.2020.0387} } @article{liu2018-29429971, author = {Liu, E. and Wang, D. and Sperling, R. and Salloway, S. and Fox, N. C. and Blennow, K. and Scheltens, P. and Schmidt, M. E. and others}, title = {{Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005060}, pmid = {29429971}, url = {https://doi.org/10.1212/wnl.0000000000005060} } @article{yang2024-38315899, author = {Yang, H. S. and Yau, W. W. and Carlyle, B. C. and Trombetta, B. A. and Zhang, C. and Shirzadi, Z. and Schultz, A. P. and Pruzin, J. J. and others}, title = {{Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2024}, doi = {10.1093/brain/awae034}, pmid = {38315899}, url = {https://doi.org/10.1093/brain/awae034} } @article{yu2015-25365775, author = {Yu, L. and Chibnik, L. B. and Srivastava, G. P. and Pochet, N. and Yang, J. and Xu, J. and Kozubek, J. and Obholzer, N. and others}, title = {{Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2014.3049}, pmid = {25365775}, url = {https://doi.org/10.1001/jamaneurol.2014.3049} } @article{dubbelman2025-40440591, author = {Dubbelman, M. A. and Liu, A. and Donohue, M. C. and Langford, O. and Raman, R. and Rentz, D. M. and Amariglio, R. and Sperling, R. A. and others}, title = {{Changes in Daily Functioning in Association With Tau and Amyloid Among Unimpaired Older Adults With and Without Elevated Amyloid}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213775}, pmid = {40440591}, url = {https://doi.org/10.1212/wnl.0000000000213775} } @article{chen2016-26086180, author = {Chen, J. C. and Espeland, M. A. and Brunner, R. L. and Lovato, L. C. and Wallace, R. B. and Leng, X. and Phillips, L. S. and Robinson, J. G. and others}, title = {{Sleep duration, cognitive decline, and dementia risk in older women}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2016}, doi = {10.1016/j.jalz.2015.03.004}, pmid = {26086180}, url = {https://doi.org/10.1016/j.jalz.2015.03.004} } @article{gleason2015-26352694, author = {Gleason, L. J. and Schmitt, E. M. and Kosar, C. M. and Tabloski, P. and Saczynski, J. S. and Robinson, T. and Cooper, Z. and Rogers, S. O. and others}, title = {{Effect of Delirium and Other Major Complications on Outcomes After Elective Surgery in Older Adults}}, journal = {JAMA surgery}, year = {2015}, doi = {10.1001/jamasurg.2015.2606}, pmid = {26352694}, url = {https://doi.org/10.1001/jamasurg.2015.2606} } @article{ayton2015-25988319, author = {Ayton, S. and Faux, N. G. and Bush, A. I. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE}}, journal = {Nature communications}, year = {2015}, doi = {10.1038/ncomms7760}, pmid = {25988319}, url = {https://doi.org/10.1038/ncomms7760} } @article{carrasquillo2017-27939925, author = {Carrasquillo, M. M. and Allen, M. and Burgess, J. D. and Wang, X. and Strickland, S. L. and Aryal, S. and Siuda, J. and Kachadoorian, M. L. and others}, title = {{A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.10.005}, pmid = {27939925}, url = {https://doi.org/10.1016/j.jalz.2016.10.005} } @article{himali2023-37902739, author = {Himali, J. J. and Baril, A. A. and Cavuoto, M. G. and Yiallourou, S. and Wiedner, C. D. and Himali, D. and others}, title = {{Association Between Slow-Wave Sleep Loss and Incident Dementia}}, journal = {JAMA Neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3889}, pmid = {37902739}, url = {https://doi.org/10.1001/jamaneurol.2023.3889} } @article{bakkour2009-19109536, author = {Bakkour, A. and Morris, J. C. and Dickerson, B. C.}, title = {{The cortical signature of prodromal AD: regional thinning predicts mild AD dementia}}, journal = {Neurology}, year = {2009}, doi = {10.1212/01.wnl.0000340981.97664.2f}, pmid = {19109536}, url = {https://doi.org/10.1212/01.wnl.0000340981.97664.2f} } @article{shirzadi2023-37843849, author = {Shirzadi, Z. and Schultz, S. A. and Yau, W. W. and Joseph-Mathurin, N. and Fitzpatrick, C. D. and Levin, R. and Kantarci, K. and Preboske, G. M. and others}, title = {{Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3618}, pmid = {37843849}, url = {https://doi.org/10.1001/jamaneurol.2023.3618} } @article{wang2022-35315884, author = {Wang, W. and Zhang, M. J. and Inciardi, R. M. and Norby, F. L. and Johansen, M. C. and Parikh, R. and Hof, JR., Van't and Alonso, A. and others}, title = {{Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia}}, journal = {JAMA}, year = {2022}, doi = {10.1001/jama.2022.2518}, pmid = {35315884}, url = {https://doi.org/10.1001/jama.2022.2518} } @article{young2018-30323170, author = {Young, A. L. and Marinescu, R. V. and Oxtoby, N. P. and Bocchetta, M. and Yong, K. and Firth, N. C. and Cash, D. M. and Thomas, D. L. and others}, title = {{Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference}}, journal = {Nature communications}, year = {2018}, doi = {10.1038/s41467-018-05892-0}, pmid = {30323170}, url = {https://doi.org/10.1038/s41467-018-05892-0} } @article{mcgrath2017-29117954, author = {McGrath, E. R. and Beiser, A. S. and DeCarli, C. and Plourde, K. L. and Vasan, R. S. and Greenberg, S. M. and Seshadri, S.}, title = {{Blood pressure from mid- to late life and risk of incident dementia}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004741}, pmid = {29117954}, url = {https://doi.org/10.1212/wnl.0000000000004741} } @article{halabi2024-39666337, author = {Halabi, Cathra and Izzy, Saef and DiGiorgio, Anthony Michael and Mills, Hunter and Radmanesh, Farid and Yue, John K. and Choshali, Habibeh Ashouri and Schenk, Gundolf and others}, title = {{Traumatic Brain Injury and Risk of Incident Comorbidities}}, journal = {JAMA Network Open}, year = {2024}, doi = {10.1001/jamanetworkopen.2024.50499}, pmid = {39666337}, url = {https://doi.org/10.1001/jamanetworkopen.2024.50499} } @article{humbert2025-40167274, author = {Humbert, Marc and McLaughlin, Vallerie V. and Badesch, David B. and Ghofrani, Hossein Ardeschir and Gibbs, J. Simon R. and Gomberg‐Maitland, Mardi and Preston, Ioana R. and Souza, Rogério and others}, title = {{Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death}}, journal = {New England Journal of Medicine}, year = {2025}, doi = {10.1056/nejmoa2415160}, pmid = {40167274}, url = {https://doi.org/10.1056/nejmoa2415160} } @article{chen2026-41604149, author = {Chen, Bowen and Xue, Erxu and Li, Yining and Tang, Enze and Wang, Yaojie and Wu, Yue and Liu, Shan and Zhao, Jianhui}, title = {{Life-Course Psychosocial Stress and Risk of Dementia and Stroke in Middle-Aged and Older Adults}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2025.56012}, pmid = {41604149}, url = {https://doi.org/10.1001/jamanetworkopen.2025.56012} } @article{buckley2019-30715078, author = {Buckley, R. F. and Mormino, E. C. and Rabin, J. S. and Hohman, T. J. and Landau, S. and Hanseeuw, B. J. and Jacobs, H. I. L. and Papp, K. V. and others}, title = {{Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2018.4693}, pmid = {30715078}, url = {https://doi.org/10.1001/jamaneurol.2018.4693} } @article{amariglio2015-25706191, author = {Amariglio, R. E. and Donohue, M. C. and Marshall, G. A. and Rentz, D. M. and Salmon, D. P. and Ferris, S. H. and Karantzoulis, S. and Aisen, P. S. and others}, title = {{Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2014.3375}, pmid = {25706191}, url = {https://doi.org/10.1001/jamaneurol.2014.3375} } @article{liu2015-26208959, author = {Liu, E. and Schmidt, M. E. and Margolin, R. and Sperling, R. and Koeppe, R. and Mason, N. S. and Klunk, W. E. and Mathis, C. A. and others}, title = {{Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001877}, pmid = {26208959}, url = {https://doi.org/10.1212/wnl.0000000000001877} } @article{vandyck2019-31329216, author = {van Dyck, C. H. and Nygaard, H. B. and Chen, K. and Donohue, M. C. and Raman, R. and Rissman, R. A. and Brewer, J. B. and Koeppe, R. A. and others}, title = {{Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2019.2050}, pmid = {31329216}, url = {https://doi.org/10.1001/jamaneurol.2019.2050} } @article{chappell2007-17389305, author = {Chappell, A. S. and Gonzales, C. and Williams, J. and Witte, M. M. and Mohs, R. C. and Sperling, R.}, title = {{AMPA potentiator treatment of cognitive deficits in Alzheimer disease}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000260240.46070.7c}, pmid = {17389305}, url = {https://doi.org/10.1212/01.wnl.0000260240.46070.7c} } @article{sevinc2021-34512305, author = {Sevinc, G. and Rusche, J. and Wong, B. and Datta, T. and Kaufman, R. and Gutz, S. E. and Schneider, M. and Todorova, N. and others}, title = {{Mindfulness Training Improves Cognition and Strengthens Intrinsic Connectivity Between the Hippocampus and Posteromedial Cortex in Healthy Older Adults}}, journal = {Frontiers in aging neuroscience}, year = {2021}, doi = {10.3389/fnagi.2021.702796}, pmid = {34512305}, url = {https://doi.org/10.3389/fnagi.2021.702796} } @article{strikwerdabrown2022-35907254, author = {Strikwerda-Brown, C. and Hobbs, D. A. and Gonneaud, J. and St-Onge, F. and Binette, A. P. and Ozlen, H. and Provost, K. and Soucy, J. P. and others}, title = {{Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.2379}, pmid = {35907254}, url = {https://doi.org/10.1001/jamaneurol.2022.2379} } @article{buckley2017-28592457, author = {Buckley, R. F. and Schultz, A. P. and Hedden, T. and Papp, K. V. and Hanseeuw, B. J. and Marshall, G. and Sepulcre, J. and Smith, E. E. and others}, title = {{Functional network integrity presages cognitive decline in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004059}, pmid = {28592457}, url = {https://doi.org/10.1212/wnl.0000000000004059} } @article{lee2019-30760848, author = {Lee, G. and Nho, K. and Kang, B. and Sohn, K. A. and Kim, D. and {for Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Predicting Alzheimer's disease progression using multi-modal deep learning approach}}, journal = {Scientific reports}, year = {2019}, doi = {10.1038/s41598-018-37769-z}, pmid = {30760848}, url = {https://doi.org/10.1038/s41598-018-37769-z} } @article{liu2017-28629879, author = {Liu, G. and Locascio, J. J. and Corvol, J. C. and Boot, B. and Liao, Z. and Page, K. and Franco, D. and Burke, K. and others}, title = {{Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts}}, journal = {The Lancet. Neurology}, year = {2017}, doi = {10.1016/s1474-4422(17)30122-9}, pmid = {28629879}, url = {https://doi.org/10.1016/s1474-4422(17)30122-9} } @article{li2025-39813632, author = {Li, Yuhan and Li, Yanping and Gu, Xiao and Liu, Yuxi and Dong, Danyue and Kang, Jae Hee and Wang, Molin and Eliassen, A. Heather and others}, title = {{Long-Term Intake of Red Meat in Relation to Dementia Risk and Cognitive Function in US Adults}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000210286}, pmid = {39813632}, url = {https://doi.org/10.1212/wnl.0000000000210286} } @article{ni2025-41327300, author = {Ni, Jiaqi and Hernández-Cacho, Adrián and Nishi, Stephanie K. and Babió, Nancy and Belzer, Clara and Konstati, Prokopis and Vioqué, Jesús and Corella, Dolores and others}, title = {{Mediterranean diet, gut microbiota, and cognitive decline in older adults with obesity/overweight and metabolic syndrome: a prospective cohort study}}, journal = {BMC Medicine}, year = {2025}, doi = {10.1186/s12916-025-04488-y}, pmid = {41327300}, url = {https://doi.org/10.1186/s12916-025-04488-y} } @article{lambert2013-24162737, author = {Lambert, Jean‐Charles and Ibrahim‐Verbaas, Carla A. and Harold, Denise H. and Naj, Adam Christian and Sims, Rebecca and Bellenguez, Céline and others}, title = {{Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease}}, journal = {Nature Genetics}, year = {2013}, doi = {10.1038/ng.2802}, pmid = {24162737}, url = {https://doi.org/10.1038/ng.2802} } @article{dubois2014-24849862, author = {Dubois, Bruno and Feldman, Howard and Jacova, Claudia and Hampel, Harald Juergen and Molinuevo, José Luís and Blennow, Kaj and DeKosky, Steven T. and Gauthier, Serge G. and others}, title = {{Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria}}, journal = {The Lancet Neurology}, year = {2014}, doi = {10.1016/s1474-4422(14)70090-0}, pmid = {24849862}, url = {https://doi.org/10.1016/s1474-4422(14)70090-0} } @article{harrison2026-42008251, author = {Harrison, T. M. and Harvey, D. J. and Chadwick, T. and Chao, Y. and Taggett, J. and Maillard, P. and Lovato, L. and Farias, S. T. and Papp, K. V. and Lockhart, S. N. and others}, title = {{Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study}}, journal = {JAMA Neurology}, year = {2026}, doi = {10.1001/jamaneurol.2026.0832}, pmid = {42008251}, url = {https://doi.org/10.1001/jamaneurol.2026.0832} } @article{ordoobadi2024-39348117, author = {Ordoobadi, A. J. and Dhanani, H. and Tulebaev, SR. and Salim, A. and Cooper, Z. and Jarman, M. P.}, title = {{Risk of Dementia Diagnosis After Injurious Falls in Older Adults}}, journal = {JAMA Network Open}, year = {2024}, doi = {10.1001/jamanetworkopen.2024.36606}, pmid = {39348117}, url = {https://doi.org/10.1001/jamanetworkopen.2024.36606} } @article{josephmathurin2022-36151869, author = {Joseph-Mathurin, N. and Llibre-Guerra, J. J. and Li, Y. and McCullough, A. A. and Hofmann, C. and Wojtowicz, J. and Park, E. and Wang, G. and others}, title = {{Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease}}, journal = {Annals of neurology}, year = {2022}, doi = {10.1002/ana.26511}, pmid = {36151869}, url = {https://doi.org/10.1002/ana.26511} } @article{shi2017-28959956, author = {Shi, Y. and Yamada, K. and Liddelow, S. A. and Smith, S. T. and Zhao, L. and Luo, W. and Tsai, R. M. and Spina, S. and others}, title = {{ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature24016}, pmid = {28959956}, url = {https://doi.org/10.1038/nature24016} } @article{donohue2014-24886908, author = {Donohue, M. C. and Sperling, R. A. and Salmon, D. P. and Rentz, D. M. and Raman, R. and Thomas, R. G. and Weiner, M. and Aisen, P. S. and others}, title = {{The preclinical Alzheimer cognitive composite: measuring amyloid-related decline}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.803}, pmid = {24886908}, url = {https://doi.org/10.1001/jamaneurol.2014.803} } @article{mormino2014-24748674, author = {Mormino, E. C. and Betensky, R. A. and Hedden, T. and Schultz, A. P. and Ward, A. and Huijbers, W. and Rentz, D. M. and Johnson, K. A. and others}, title = {{Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000431}, pmid = {24748674}, url = {https://doi.org/10.1212/wnl.0000000000000431} } @article{zhang2008-18192497, author = {Zhang, B. and Mitchell, S. L. and Bambauer, K. Z. and Jones, R. and Prigerson, H. G.}, title = {{Depressive symptom trajectories and associated risks among bereaved Alzheimer disease caregivers}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2008}, doi = {10.1097/jgp.0b013e318157caec}, pmid = {18192497}, url = {https://doi.org/10.1097/jgp.0b013e318157caec} } @article{christensen2016-26810768, author = {Christensen, K. D. and Roberts, J. S. and Whitehouse, P. J. and Royal, C. D. and Obisesan, T. O. and Cupples, L. A. and Vernarelli, J. A. and Bhatt, D. L. and others}, title = {{Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial}}, journal = {Annals of internal medicine}, year = {2016}, doi = {10.7326/m15-0187}, pmid = {26810768}, url = {https://doi.org/10.7326/m15-0187} } @article{rentz2024-39044489, author = {Rentz, D. M. and Rosenberg, P. B. and Sperling, R. A. and Donohue, M. C. and Raman, R. and Liu, A. and Aisen, P. S.}, title = {{Characterizing Clinical Progression in Cognitively Unimpaired Older Individuals with Brain Amyloid: Results from the A4 Study}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.123}, pmid = {39044489}, url = {https://doi.org/10.14283/jpad.2024.123} } @article{tranah2011-22162057, author = {Tranah, G. J. and Blackwell, T. and Stone, K. L. and Ancoli-Israel, S. and Paudel, M. L. and Ensrud, K. E. and Cauley, J. A. and Redline, S. and others}, title = {{Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22468}, pmid = {22162057}, url = {https://doi.org/10.1002/ana.22468} } @article{racine2021-33078300, author = {Racine, A. M. and Tommet, D. and D'Aquila, M. L. and Fong, T. G. and Gou, Y. and Tabloski, P. A. and Metzger, E. D. and Hshieh, T. T. and others}, title = {{Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients}}, journal = {Journal of general internal medicine}, year = {2021}, doi = {10.1007/s11606-020-06238-7}, pmid = {33078300}, url = {https://doi.org/10.1007/s11606-020-06238-7} } @article{weiner2017-28342697, author = {Weiner, M. W. and Veitch, D. P. and Aisen, P. S. and Beckett, L. A. and Cairns, N. J. and Green, R. C. and Harvey, D. and Jack, C. R. and others}, title = {{Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.11.007}, pmid = {28342697}, url = {https://doi.org/10.1016/j.jalz.2016.11.007} } @article{bian2025-39920677, author = {Bian, Wenxin and Biswas, Raaj Kishore and Ahmadi, Matthew N. and Bin, Yu Sun and Postnova, Svetlana and Phillips, Andrew J. K. and Koemel, Nicholas A. and Chaput, Jean‐Philippe and others}, title = {{Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults}}, journal = {BMC Public Health}, year = {2025}, doi = {10.1186/s12889-025-21649-z}, pmid = {39920677}, url = {https://doi.org/10.1186/s12889-025-21649-z} } @article{hardy2002-12130773, author = {Hardy, John and Selkoe, Dennis J.}, title = {{The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics}}, journal = {Science}, year = {2002}, doi = {10.1126/science.1072994}, pmid = {12130773}, url = {https://doi.org/10.1126/science.1072994} } @article{hong2016-27033548, author = {Hong, S. and Beja-Glasser, V. F. and Nfonoyim, B. M. and Frouin, A. and Li, S. and Ramakrishnan, S. and Merry, K. M. and Shi, Q. and others}, title = {{Complement and microglia mediate early synapse loss in Alzheimer mouse models}}, journal = {Science (New York, N.Y.)}, year = {2016}, doi = {10.1126/science.aad8373}, pmid = {27033548}, url = {https://doi.org/10.1126/science.aad8373} } @article{ge2018-29592889, author = {Ge, T. and Sabuncu, M. R. and Smoller, J. W. and Sperling, R. A. and Mormino, E. C. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005415}, pmid = {29592889}, url = {https://doi.org/10.1212/wnl.0000000000005415} } @article{atri2011-21555634, author = {Atri, A. and O'Brien, J. L. and Sreenivasan, A. and Rastegar, S. and Salisbury, S. and DeLuca, A. N. and O'Keefe, K. M. and LaViolette, P. S. and others}, title = {{Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2011.94}, pmid = {21555634}, url = {https://doi.org/10.1001/archneurol.2011.94} } @article{mace2024-39571150, author = {Mace, R. A. and Law, M. E. and Cohen, J. E. and Ritchie, C. S. and Okereke, O. I. and Hoeppner, B. B. and Brewer, J. A. and Bartels, S. J. and others}, title = {{A Mindfulness-Based Lifestyle Intervention for Dementia Risk Reduction: Protocol for the My Healthy Brain Feasibility Randomized Controlled Trial}}, journal = {JMIR research protocols}, year = {2024}, doi = {10.2196/64149}, pmid = {39571150}, url = {https://doi.org/10.2196/64149} } @article{jack2018-29653606, author = {Jack, C. R. and Bennett, D. A. and Blennow, K. and Carrillo, M. C. and Dunn, B. and Haeberlein, S. B. and Holtzman, D. M. and Jagust, W. and others}, title = {{NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2018}, doi = {10.1016/j.jalz.2018.02.018}, pmid = {29653606}, url = {https://doi.org/10.1016/j.jalz.2018.02.018} } @article{dickerson2011-21490323, author = {Dickerson, B. C. and Stoub, T. R. and Shah, R. C. and Sperling, R. A. and Killiany, R. J. and Albert, M. S. and Hyman, B. T. and Blacker, D. and others}, title = {{Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e3182166e96}, pmid = {21490323}, url = {https://doi.org/10.1212/wnl.0b013e3182166e96} } @article{brown2022-35197628, author = {Brown, A. L. and Wilkins, O. G. and Keuss, M. J. and Kargbo-Hill, S. E. and Zanovello, M. and Lee, W. C. and Bampton, A. and Lee, F. C. Y. and others}, title = {{TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-04436-3}, pmid = {35197628}, url = {https://doi.org/10.1038/s41586-022-04436-3} } @article{beecham2014-25188341, author = {Beecham, G. W. and Hamilton, K. and Naj, A. C. and Martin, E. R. and Huentelman, M. and Myers, A. J. and Corneveaux, J. J. and Hardy, J. and others}, title = {{Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias}}, journal = {PLoS genetics}, year = {2014}, doi = {10.1371/journal.pgen.1004606}, pmid = {25188341}, url = {https://doi.org/10.1371/journal.pgen.1004606} } @article{devore2010-20625087, author = {Devore, E. E. and Grodstein, F. and van Rooij, F. J. and Hofman, A. and Stampfer, M. J. and Witteman, J. C. and Breteler, M. M.}, title = {{Dietary antioxidants and long-term risk of dementia}}, journal = {Archives of neurology}, year = {2010}, doi = {10.1001/archneurol.2010.144}, pmid = {20625087}, url = {https://doi.org/10.1001/archneurol.2010.144} } @article{yiallourou2025-40377976, author = {Yiallourou, Stephanie R and Baril, Andrée‐Ann and Wiedner, Crystal and Misialek, Jeffrey R. and Kline, Christopher E. and Harrison, Stephanie Litwack and Cannon, Ethan J. and Yang, Qiong and others}, title = {{Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium}}, journal = {SLEEP}, year = {2025}, doi = {10.1093/sleep/zsaf129}, pmid = {40377976}, url = {https://doi.org/10.1093/sleep/zsaf129} } @article{vassar1999-10531052, author = {Vassar, Robert J. and Bennett, Brian D. and Babu‐Khan, Safura and Kahn, Steve and Mendiaz, Elizabeth A. and Denis, Paul E. and Teplow, David B. and Ross, Sandra L. and others}, title = {{β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE}}, journal = {Science}, year = {1999}, doi = {10.1126/science.286.5440.735}, pmid = {10531052}, url = {https://doi.org/10.1126/science.286.5440.735} } @article{page2021-33782057, author = {Page, Matthew James and McKenzie, Joanne E. and Bossuyt, Patrick M. and Boutron, Isabelle and Hoffmann, Tammy and Mulrow, Cynthia D. and Shamseer, Larissa and Tetzlaff, Jennifer and Akl, Elie A. and Brennan, Sue and Chou, Roger and Glanville, Julie and Grimshaw, Jeremy and Hróbjartsson, Asbjørn and Lalu, Manoj Mathew and Li, Tianjing and Loder, Elizabeth and Mayo‐Wilson, Evan and McDonald, Steve J and McGuinness, Luke A. and Stewart, Lesley A. and Thomas, James and Tricco, Andrea C. and Welch, Vivian Andrea and Whiting, Penny F. and Moher, David}, title = {{The PRISMA 2020 statement: an updated guideline for reporting systematic reviews}}, journal = {BMJ}, year = {2021}, doi = {10.1136/bmj.n71}, pmid = {33782057}, url = {https://doi.org/10.1136/bmj.n71} } @article{vandyck2025-41355080, author = {van Dyck, C. H. and Sperling, R. and Johnson, K. and Dhadda, S. and Kanekiyo, M. and Li, D. and Gee, M. and Hersch, S. and Irizarry, M. and Kramer, L.}, title = {{Long-term safety and efficacy of lecanemab in early Alzheimer's disease: Results from the Clarity AD open-label extension study}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70905}, pmid = {41355080}, url = {https://doi.org/10.1002/alz.70905} } @article{atri2026-42128444, author = {Atri, A. and Apostolova, L. G. and Iwata, A. and Wessels, A. M. and Atkins, A. and Lu, M. and Ye, W. and Ryan, S. and Doty, E. G.}, title = {{Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial}}, journal = {Neurology: Clinical Practice}, year = {2026}, doi = {10.1212/CPJ.0000000000200621}, pmid = {42128444}, url = {https://doi.org/10.1212/CPJ.0000000000200621} } @article{young2022-35435938, author = {Young, C. B. and Winer, JR. and Younes, K. and Cody, K. A. and Betthauser, T. J. and Johnson, S. C. and Schultz, A. and Sperling, R. A. and others}, title = {{Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.0676}, pmid = {35435938}, url = {https://doi.org/10.1001/jamaneurol.2022.0676} } @article{hofmann2024-39557867, author = {Hofmann, A. and Häsler, L. M. and Lambert, M. and Kaeser, S. A. and Gräber-Sultan, S. and Obermüller, U. and Kuder-Buletta, E. and la Fougere, C. and others}, title = {{Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease}}, journal = {Nature communications}, year = {2024}, doi = {10.1038/s41467-024-52937-8}, pmid = {39557867}, url = {https://doi.org/10.1038/s41467-024-52937-8} } @article{obrien2010-20463288, author = {O'Brien, J. L. and O'Keefe, K. M. and LaViolette, P. S. and DeLuca, A. N. and Blacker, D. and Dickerson, B. C. and Sperling, R. A.}, title = {{Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181e3966e}, pmid = {20463288}, url = {https://doi.org/10.1212/wnl.0b013e3181e3966e} } @article{grill2024-37830926, author = {Grill, J. D. and Flournoy, C. and Dhadda, S. and Ernstrom, K. and Sperling, R. and Molina-Henry, D. and Tranotti, K. and Harris, R. and others}, title = {{Eligibility Rates among Racially and Ethnically Diverse US Participants in Phase 2 and Phase 3 Placebo-Controlled, Double-Blind, Randomized Trials of Lecanemab and Elenbecestat in Early Alzheimer Disease}}, journal = {Annals of neurology}, year = {2024}, doi = {10.1002/ana.26819}, pmid = {37830926}, url = {https://doi.org/10.1002/ana.26819} } @article{reiman2012-23137948, author = {Reiman, E. M. and Quiroz, Y. T. and Fleisher, A. S. and Chen, K. and Velez-Pardo, C. and Jimenez-Del-Rio, M. and Fagan, A. M. and Shah, A. R. and others}, title = {{Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study}}, journal = {The Lancet. Neurology}, year = {2012}, doi = {10.1016/s1474-4422(12)70228-4}, pmid = {23137948}, url = {https://doi.org/10.1016/s1474-4422(12)70228-4} } @article{lee2016-27016429, author = {Lee, S. and Viqar, F. and Zimmerman, M. E. and Narkhede, A. and Tosto, G. and Benzinger, T. L. and Marcus, D. S. and Fagan, A. M. and others}, title = {{White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network}}, journal = {Annals of neurology}, year = {2016}, doi = {10.1002/ana.24647}, pmid = {27016429}, url = {https://doi.org/10.1002/ana.24647} } @article{marcantonio2000-10855596, author = {Marcantonio, E. R. and Flacker, J. M. and Michaels, M. and Resnick, N. M.}, title = {{Delirium is independently associated with poor functional recovery after hip fracture}}, journal = {Journal of the American Geriatrics Society}, year = {2000}, doi = {10.1111/j.1532-5415.2000.tb04718.x}, pmid = {10855596}, url = {https://doi.org/10.1111/j.1532-5415.2000.tb04718.x} } @article{huijbers2015-25678559, author = {Huijbers, W. and Mormino, E. C. and Schultz, A. P. and Wigman, S. and Ward, A. M. and Larvie, M. and Amariglio, R. E. and Marshall, G. A. and others}, title = {{Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression}}, journal = {Brain : a journal of neurology}, year = {2015}, doi = {10.1093/brain/awv007}, pmid = {25678559}, url = {https://doi.org/10.1093/brain/awv007} } @article{krasemann2017-28930663, author = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others}, title = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}}, journal = {Immunity}, year = {2017}, doi = {10.1016/j.immuni.2017.08.008}, pmid = {28930663}, url = {https://doi.org/10.1016/j.immuni.2017.08.008} } @article{dickerson2007-18056553, author = {Dickerson, B. C. and Sperling, R. A. and Hyman, B. T. and Albert, M. S. and Blacker, D.}, title = {{Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment}}, journal = {Archives of general psychiatry}, year = {2007}, doi = {10.1001/archpsyc.64.12.1443}, pmid = {18056553}, url = {https://doi.org/10.1001/archpsyc.64.12.1443} } @article{zhong2024-39106873, author = {Zhong, J. and Zhang, Y. and Zhu, K. and Li, R. and Zhou, X. and Yao, P. and Franco, O. H. and Manson, J. E. and others}, title = {{Associations of social determinants of health with life expectancy and future health risks among individuals with type 2 diabetes: two nationwide cohort studies in the UK and USA}}, journal = {The lancet. Healthy longevity}, year = {2024}, doi = {10.1016/s2666-7568(24)00116-8}, pmid = {39106873}, url = {https://doi.org/10.1016/s2666-7568(24)00116-8} } @article{grill2026-41910973, author = {Grill, Joshua D. and RAMAN, REMA and Wang, Shunran and Ernstrom, Karin B. and Andrews, Patricia and Appleby, Brian Stephen and Bhangu, Jaspreet S. and Dhadda, Shobha and others}, title = {{Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.3845}, pmid = {41910973}, url = {https://doi.org/10.1001/jamanetworkopen.2026.3845} } @article{mormino2016-27548655, author = {Mormino, E. C. and Papp, K. V. and Rentz, D. M. and Schultz, A. P. and LaPoint, M. and Amariglio, R. and Hanseeuw, B. and Marshall, G. A. and others}, title = {{Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.2237}, pmid = {27548655}, url = {https://doi.org/10.1001/jamaneurol.2016.2237} } @article{schultz2024-39074479, author = {Schultz, S. A. and Liu, L. and Schultz, A. P. and Fitzpatrick, C. D. and Levin, R. and Bellier, J. P. and Shirzadi, Z. and Joseph-Mathurin, N. and others}, title = {{γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)}}, journal = {The Lancet. Neurology}, year = {2024}, doi = {10.1016/s1474-4422(24)00236-9}, pmid = {39074479}, url = {https://doi.org/10.1016/s1474-4422(24)00236-9} } @article{shankar2008-18568035, author = {Shankar, Ganesh M. and Li, Shaomin and Mehta, Tapan and García-Muñoz, Amaya and Shepardson, Nina E. and Smith, Imelda M. and Brett, Francesca M. and Farrell, Michael Anthony and Rowan, Michael J. and Lemere, Cynthia Ann and Regan, Ciaran M. and Walsh, Dominic M. and Sabatini, Bernardo Luis and Selkoe, Dennis J.}, title = {{Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory}}, journal = {Nature Medicine}, year = {2008}, doi = {10.1038/nm1782}, pmid = {18568035}, url = {https://doi.org/10.1038/nm1782} } @article{kivisakk2022-35800899, author = {Kivisäkk, P. and Magdamo, C. and Trombetta, B. A. and Noori, A. and Kuo, Y. K. E. and Chibnik, L. B. and Carlyle, B. C. and Serrano-Pozo, A. and others}, title = {{Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment}}, journal = {Brain communications}, year = {2022}, doi = {10.1093/braincomms/fcac155}, pmid = {35800899}, url = {https://doi.org/10.1093/braincomms/fcac155} } @article{sperling2012-22305802, author = {Sperling, R. and Salloway, S. and Brooks, D. J. and Tampieri, D. and Barakos, J. and Fox, N. C. and Raskind, M. and Sabbagh, M. and others}, title = {{Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis}}, journal = {The Lancet. Neurology}, year = {2012}, doi = {10.1016/s1474-4422(12)70015-7}, pmid = {22305802}, url = {https://doi.org/10.1016/s1474-4422(12)70015-7} } @article{roberts2012-22498844, author = {Roberts, J. S. and Chen, C. A. and Uhlmann, W. R. and Green, R. C.}, title = {{Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease}}, journal = {Genetics in medicine : official journal of the American College of Medical Genetics}, year = {2012}, doi = {10.1038/gim.2012.37}, pmid = {22498844}, url = {https://doi.org/10.1038/gim.2012.37} } @article{katzmarzyk2022-33782046, author = {Katzmarzyk, P. T. and Friedenreich, C. and Shiroma, E. J. and Lee, I. M.}, title = {{Physical inactivity and non-communicable disease burden in low-income, middle-income and high-income countries}}, journal = {British journal of sports medicine}, year = {2022}, doi = {10.1136/bjsports-2020-103640}, pmid = {33782046}, url = {https://doi.org/10.1136/bjsports-2020-103640} } @article{buckley2017-28973551, author = {Buckley, R. F. and Hanseeuw, B. and Schultz, A. P. and Vannini, P. and Aghjayan, S. L. and Properzi, M. J. and Jackson, J. D. and Mormino, E. C. and others}, title = {{Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.2216}, pmid = {28973551}, url = {https://doi.org/10.1001/jamaneurol.2017.2216} } @article{benner2002-12132975, author = {Benner, J. S. and Glynn, R. J. and Mogun, H. and Neumann, P. J. and Weinstein, M. C. and Avorn, J.}, title = {{Long-term persistence in use of statin therapy in elderly patients}}, journal = {JAMA}, year = {2002}, doi = {10.1001/jama.288.4.455}, pmid = {12132975}, url = {https://doi.org/10.1001/jama.288.4.455} } @article{li2020-34179863, author = {Li, P. and Gao, L. and Gaba, A. and Yu, L. and Cui, L. and Fan, W. and Lim, A. S. P. and Bennett, D. A. and others}, title = {{Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults}}, journal = {The lancet. Healthy longevity}, year = {2020}, doi = {10.1016/s2666-7568(20)30015-5}, pmid = {34179863}, url = {https://doi.org/10.1016/s2666-7568(20)30015-5} } @article{ulsa2022-34558609, author = {Ulsa, M. C. and Xi, Z. and Li, P. and Gaba, A. and Wong, P. M. and Saxena, R. and Scheer, F. A. J. L. and Rutter, M. and others}, title = {{Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization}}, journal = {The journals of gerontology. Series A, Biological sciences and medical sciences}, year = {2022}, doi = {10.1093/gerona/glab272}, pmid = {34558609}, url = {https://doi.org/10.1093/gerona/glab272} } @article{mormino2017-28253478, author = {Mormino, E. C. and Papp, K. V. and Rentz, D. M. and Donohue, M. C. and Amariglio, R. and Quiroz, Y. T. and Chhatwal, J. and Marshall, G. A. and others}, title = {{Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2017.01.018}, pmid = {28253478}, url = {https://doi.org/10.1016/j.jalz.2017.01.018} } @article{butovsky2013-24316888, author = {Butovsky, Oleg and Jedrychowski, Mark P. and Moore, Craig Stephen and Cialic, Ron and Lanser, Amanda J. and Gabriely, Galina and Koeglsperger, Thomas and Dake, Ben and Wu, Pauline M. and Doykan, Camille E. and Fanek, Zain and Liu, Liping and Chen, Zhuoxun and Rothstein, Jeffrey D. and Ransohoff, Richard M. and Gygi, Steven P. and Antel, Jack Perry and Weiner, Howard L.}, title = {{Identification of a unique TGF-β–dependent molecular and functional signature in microglia}}, journal = {Nature Neuroscience}, year = {2013}, doi = {10.1038/nn.3599}, pmid = {24316888}, url = {https://doi.org/10.1038/nn.3599} } @article{winblad2016-26987701, author = {Winblad, Bengt G. and Amouyel, Philippe and Andrieu, Sandrine and Ballard, Clive G. and Brayne, Carol and Brodaty, Henry and Cedazo-Mínguez, Ángel and Dubois, Bruno and Edvardsson, David and Feldman, Howard and Fratiglioni, Laura and Frisoni, Giovanni Battista and Gauthier, Serge G. and Georges, Jean and Graff, Caroline and Iqbal, Khalid and Jessen, Frank and Johansson, Gunilla and Jönsson, Linus and Kivipelto, Miia and Knapp, Martin Richard John and Mangialasche, Francesca and Melis, René J. F. and Nordberg, Agneta K. and Rikkert, Marcel G. M. Olde and Qiu, Chengxuan and Sakmar, Thomas P. and Scheltens, Philip and Schneider, Lon S. S. and Sperling, Reisa Anne and Tjernberg, Lars O. and Waldemar, Gunhild and Wimo, Anders and Zetterberg, Henrik}, title = {{Defeating Alzheimer's disease and other dementias: a priority for European science and society}}, journal = {The Lancet Neurology}, year = {2016}, doi = {10.1016/s1474-4422(16)00062-4}, pmid = {26987701}, url = {https://doi.org/10.1016/s1474-4422(16)00062-4} } @article{jessen2020-31958406, author = {Jessen, Frank and Amariglio, Rebecca England and Buckley, Rachel F. and van der Flier, Wiesje M. and Han, Ying and Molinuevo, José Luís and Rabin, Laura A. and Rentz, Dorene M. and Rodríguez‐Gómez, Octavio and Saykin, Andrew J. and Sikkes, Sietske A.M. and Smart, Colette M. and Wolfsgruber, Steffen and Wagner, Michael}, title = {{The characterisation of subjective cognitive decline}}, journal = {The Lancet Neurology}, year = {2020}, doi = {10.1016/s1474-4422(19)30368-0}, pmid = {31958406}, url = {https://doi.org/10.1016/s1474-4422(19)30368-0} } @article{yu2017-28108637, author = {Yu, L. and Lutz, M. W. and Wilson, R. S. and Burns, D. K. and Roses, A. D. and Saunders, A. M. and Gaiteri, C. and De Jager, P. L. and others}, title = {{TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000003614}, pmid = {28108637}, url = {https://doi.org/10.1212/wnl.0000000000003614} } @article{seto2024-38884955, author = {Seto, M. and Hohman, T. J. and Mormino, E. C. and Papp, K. V. and Amariglio, R. E. and Rentz, D. M. and Johnson, K. A. and Schultz, A. P. and others}, title = {{Parental History of Memory Impairment and β-Amyloid in Cognitively Unimpaired Older Adults}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.1763}, pmid = {38884955}, url = {https://doi.org/10.1001/jamaneurol.2024.1763} } @article{reiman2020-32015339, author = {Reiman, E. M. and Arboleda-Velasquez, J. F. and Quiroz, Y. T. and Huentelman, M. J. and Beach, T. G. and Caselli, R. J. and Chen, Y. and Su, Y. and others}, title = {{Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study}}, journal = {Nature communications}, year = {2020}, doi = {10.1038/s41467-019-14279-8}, pmid = {32015339}, url = {https://doi.org/10.1038/s41467-019-14279-8} } @article{shah2016-27751558, author = {Shah, H. and Albanese, E. and Duggan, C. and Rudan, I. and Langa, K. M. and Carrillo, M. C. and Chan, K. Y. and Joanette, Y. and others}, title = {{Research priorities to reduce the global burden of dementia by 2025}}, journal = {The Lancet. Neurology}, year = {2016}, doi = {10.1016/s1474-4422(16)30235-6}, pmid = {27751558}, url = {https://doi.org/10.1016/s1474-4422(16)30235-6} } @article{orkaby2017-28954880, author = {Orkaby, A. R. and Cho, K. and Cormack, J. and Gagnon, D. R. and Driver, J. A.}, title = {{Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004586}, pmid = {28954880}, url = {https://doi.org/10.1212/wnl.0000000000004586} } @article{krivanek2021-33935078, author = {Krivanek, T. J. and Gale, S. A. and McFeeley, B. M. and Nicastri, C. M. and Daffner, K. R.}, title = {{Promoting Successful Cognitive Aging: A Ten-Year Update}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2021}, doi = {10.3233/jad-201462}, pmid = {33935078}, url = {https://doi.org/10.3233/jad-201462} } @article{johnson2016-26505746, author = {Johnson, K. A. and Schultz, A. and Betensky, R. A. and Becker, J. A. and Sepulcre, J. and Rentz, D. and Mormino, E. and Chhatwal, J. and others}, title = {{Tau positron emission tomographic imaging in aging and early Alzheimer disease}}, journal = {Annals of neurology}, year = {2016}, doi = {10.1002/ana.24546}, pmid = {26505746}, url = {https://doi.org/10.1002/ana.24546} } @article{mckee2016-26667418, author = {McKee, A. C. and Cairns, N. J. and Dickson, D. W. and Folkerth, R. D. and Keene, C. D. and Litvan, I. and Perl, D. P. and Stein, T. D. and others}, title = {{The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-015-1515-z}, pmid = {26667418}, url = {https://doi.org/10.1007/s00401-015-1515-z} } @article{mollenhauer2011-21317042, author = {Mollenhauer, B. and Locascio, J. J. and Schulz-Schaeffer, W. and Sixel-Döring, F. and Trenkwalder, C. and Schlossmacher, M. G.}, title = {{α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study}}, journal = {The Lancet. Neurology}, year = {2011}, doi = {10.1016/s1474-4422(11)70014-x}, pmid = {21317042}, url = {https://doi.org/10.1016/s1474-4422(11)70014-x} } @article{coughlan2023-37010830, author = {Coughlan, G. T. and Betthauser, T. J. and Boyle, R. and Koscik, R. L. and Klinger, H. M. and Chibnik, L. B. and Jonaitis, E. M. and Yau, W. W. and others}, title = {{Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.0455}, pmid = {37010830}, url = {https://doi.org/10.1001/jamaneurol.2023.0455} } @article{ruizcanela2025-40854218, author = {Ruiz‐Canela, Miguel and Corella, Dolores and Martínez‐González, Miguel Ángel and Babió, Nancy and Martínéz, J. Alfredo and Forga, Lluís and Alonso‐Gómez, Ángel M. and Wärnberǵ, Julia and others}, title = {{Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes}}, journal = {Annals of Internal Medicine}, year = {2025}, doi = {10.7326/annals-25-00388}, pmid = {40854218}, url = {https://doi.org/10.7326/annals-25-00388} } @article{selkoe2016-27025652, author = {Selkoe, Dennis J. and Hardy, John}, title = {{The amyloid hypothesis of Alzheimer's disease at 25 years}}, journal = {EMBO Molecular Medicine}, year = {2016}, doi = {10.15252/emmm.201606210}, pmid = {27025652}, url = {https://doi.org/10.15252/emmm.201606210} } @article{asai2015-26436904, author = {Asai, Hirohide and Ikezu, Seiko and Tsunoda, Satoshi and Medalla, Maria and Luebke, Jennifer Irene and Haydar, Tarik F. and Wolozin, Benjamin L. and Butovsky, Oleg and Kügler, Sebastian and Ikezu, Tsuneya}, title = {{Depletion of microglia and inhibition of exosome synthesis halt tau propagation}}, journal = {Nature Neuroscience}, year = {2015}, doi = {10.1038/nn.4132}, pmid = {26436904}, url = {https://doi.org/10.1038/nn.4132} } @article{boerwinkle2023-36517172, author = {Boerwinkle, A. H. and Gordon, B. A. and Wisch, J. and Flores, S. and Henson, R. L. and Butt, O. H. and McKay, N. and Chen, C. D. and others}, title = {{Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2023}, doi = {10.1016/s1474-4422(22)00408-2}, pmid = {36517172}, url = {https://doi.org/10.1016/s1474-4422(22)00408-2} } @article{mormino2016-27385740, author = {Mormino, E. C. and Sperling, R. A. and Holmes, A. J. and Buckner, R. L. and De Jager, P. L. and Smoller, J. W. and Sabuncu, M. R. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Polygenic risk of Alzheimer disease is associated with early- and late-life processes}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000002922}, pmid = {27385740}, url = {https://doi.org/10.1212/wnl.0000000000002922} } @article{schmitt2012-22999782, author = {Schmitt, E. M. and Marcantonio, E. R. and Alsop, D. C. and Jones, R. N. and Rogers, S. O. and Fong, T. G. and Metzger, E. and Inouye, S. K. and others}, title = {{Novel risk markers and long-term outcomes of delirium: the successful aging after elective surgery (SAGES) study design and methods}}, journal = {Journal of the American Medical Directors Association}, year = {2012}, doi = {10.1016/j.jamda.2012.08.004}, pmid = {22999782}, url = {https://doi.org/10.1016/j.jamda.2012.08.004} } @article{fagan2014-24598588, author = {Fagan, A. M. and Xiong, C. and Jasielec, M. S. and Bateman, R. J. and Goate, A. M. and Benzinger, T. L. and Ghetti, B. and Martins, R. N. and others}, title = {{Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease}}, journal = {Science translational medicine}, year = {2014}, doi = {10.1126/scitranslmed.3007901}, pmid = {24598588}, url = {https://doi.org/10.1126/scitranslmed.3007901} } @article{quiroz2018-29435558, author = {Quiroz, Y. T. and Sperling, R. A. and Norton, D. J. and Baena, A. and Arboleda-Velasquez, J. F. and Cosio, D. and Schultz, A. and Lapoint, M. and others}, title = {{Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2017.4907}, pmid = {29435558}, url = {https://doi.org/10.1001/jamaneurol.2017.4907} } @article{lo2012-22972646, author = {Lo, R. Y. and Jagust, W. J. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Vascular burden and Alzheimer disease pathologic progression}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e31826c1b9d}, pmid = {22972646}, url = {https://doi.org/10.1212/wnl.0b013e31826c1b9d} } @article{thomas2014-25069482, author = {Thomas, J. B. and Brier, M. R. and Bateman, R. J. and Snyder, A. Z. and Benzinger, T. L. and Xiong, C. and Raichle, M. and Holtzman, D. M. and others}, title = {{Functional connectivity in autosomal dominant and late-onset Alzheimer disease}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.1654}, pmid = {25069482}, url = {https://doi.org/10.1001/jamaneurol.2014.1654} } @article{donovan2016-27806159, author = {Donovan, N. J. and Okereke, O. I. and Vannini, P. and Amariglio, R. E. and Rentz, D. M. and Marshall, G. A. and Johnson, K. A. and Sperling, R. A.}, title = {{Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults}}, journal = {JAMA psychiatry}, year = {2016}, doi = {10.1001/jamapsychiatry.2016.2657}, pmid = {27806159}, url = {https://doi.org/10.1001/jamapsychiatry.2016.2657} } @article{chan2015-26414614, author = {Chan, G. and White, C. C. and Winn, P. A. and Cimpean, M. and Replogle, J. M. and Glick, L. R. and Cuerdon, N. E. and Ryan, K. J. and others}, title = {{CD33 modulates TREM2: convergence of Alzheimer loci}}, journal = {Nature neuroscience}, year = {2015}, doi = {10.1038/nn.4126}, pmid = {26414614}, url = {https://doi.org/10.1038/nn.4126} } @article{echouffotcheugui2018-30355700, author = {Echouffo-Tcheugui, J. B. and Conner, S. C. and Himali, J. J. and Maillard, P. and DeCarli, C. S. and Beiser, A. S. and Vasan, R. S. and Seshadri, S.}, title = {{Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006549}, pmid = {30355700}, url = {https://doi.org/10.1212/wnl.0000000000006549} } @article{green2024-39198642, author = {Green, G. S. and Fujita, M. and Yang, H. S. and Taga, M. and Cain, A. and McCabe, C. and Comandante-Lou, N. and White, C. C. and others}, title = {{Cellular communities reveal trajectories of brain ageing and Alzheimer's disease}}, journal = {Nature}, year = {2024}, doi = {10.1038/s41586-024-07871-6}, pmid = {39198642}, url = {https://doi.org/10.1038/s41586-024-07871-6} } @article{liang2025-39836940, author = {Liang, Jingjing and Hussainy, Sadiya and Lee, Sara Michelle and Wu, Gray and Bautista, Natalie and Ding, Mao and Wang, Heming and LAFLEUR, BONNIE J. and others}, title = {{Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000210250}, pmid = {39836940}, url = {https://doi.org/10.1212/wnl.0000000000210250} } @article{perelman2026-41540920, author = {Perelman, Sarah E. and Meeker, Melissa A and Kennedy, Maura and Joseph, Joshua W. and Liu, Shan W.}, title = {{Emergency Department Hallways Are Associated With Incident Delirium and Severe Agitation in Older Adults Living With Dementia}}, journal = {Journal of the American Geriatrics Society}, year = {2026}, doi = {10.1111/jgs.70307}, pmid = {41540920}, url = {https://doi.org/10.1111/jgs.70307} } @article{masini2025-40052267, author = {Masini, Gabriele and Wang, Wendy and Ji, Yuekai and Eaton, Anne A. and Inciardi, Riccardo Maria and Soliman, Elsayed Z. and PASSMAN, ROD S. and Solomon, Scott David and others}, title = {{Markers of Left Atrial Myopathy: Prognostic Usefulness for Ischemic Stroke and Dementia in People in Sinus Rhythm}}, journal = {Stroke}, year = {2025}, doi = {10.1161/strokeaha.124.047747}, pmid = {40052267}, url = {https://doi.org/10.1161/strokeaha.124.047747} } @article{jessen2014-24798886, author = {Jessen, Frank and Amariglio, Rebecca England and van Boxtel, Martin P.J. and Breteler, Monique M.B. and Ceccaldi, Mathieu and Chételat, Gaël and Dubois, Bruno and Dufouil, Carole and others}, title = {{A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease}}, journal = {Alzheimer s \& Dementia}, year = {2014}, doi = {10.1016/j.jalz.2014.01.001}, pmid = {24798886}, url = {https://doi.org/10.1016/j.jalz.2014.01.001} } @article{walsh2002-11932745, author = {Walsh, Dominic M. and Klyubin, Igor V. and Fadeeva, Julia V. and Cullen, William K. and Anwyl, Roger and Wolfe, Michael S. and Rowan, Michael J. and Selkoe, Dennis J.}, title = {{Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo}}, journal = {Nature}, year = {2002}, doi = {10.1038/416535a}, pmid = {11932745}, url = {https://doi.org/10.1038/416535a} } @article{selkoe2002-12399581, author = {Selkoe, Dennis J.}, title = {{Alzheimer's Disease Is a Synaptic Failure}}, journal = {Science}, year = {2002}, doi = {10.1126/science.1074069}, pmid = {12399581}, url = {https://doi.org/10.1126/science.1074069} } @article{hansson2022-35908251, author = {Hansson, Oskar and Edelmayer, Rebecca M. and Boxer, Adam L. and Carrillo, María C. and Mielke, Michelle M. and Rabinovici, Gil D. and Salloway, Stephen and Sperling, Reisa Anne and Zetterberg, Henrik and Teunissen, Charlotte Elisabeth}, title = {{The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease}}, journal = {Alzheimer s \& Dementia}, year = {2022}, doi = {10.1002/alz.12756}, pmid = {35908251}, url = {https://doi.org/10.1002/alz.12756} } @article{lopera2023-37188781, author = {Lopera, F. and Marino, C. and Chandrahas, A. S. and O'Hare, M. and Villalba-Moreno, N. D. and Aguillon, D. and Baena, A. and Sanchez, J. S. and Vila-Castelar, C. and Ramirez Gomez, L. and Chmielewska, N. and Oliveira, G. M. and others}, title = {{Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man}}, journal = {Nature Medicine}, year = {2023}, doi = {10.1038/s41591-023-02318-3}, pmid = {37188781}, url = {https://doi.org/10.1038/s41591-023-02318-3} } @article{kimura2025-40205047, author = {Kimura, K. and Subramanian, A. and Yin, Z. and Khalilnezhad, A. and Wu, Y. and He, D. and Dixon, K. O. and Chitta, U. K. and Ding, X. and Adhikari, N. and Guzchenko, I. and Zhang, X. and others}, title = {{Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease}}, journal = {Nature}, year = {2025}, doi = {10.1038/s41586-025-08852-z}, pmid = {40205047}, url = {https://doi.org/10.1038/s41586-025-08852-z} } @article{killiany2000-10762153, author = {Killiany, R. J. and Gomez-Isla, T. and Moss, M. and Kikinis, R. and Sandor, T. and Jolesz, F. and Tanzi, R. and Jones, K. and others}, title = {{Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease}}, journal = {Annals of neurology}, year = {2000}, doi = {10.1002/1531-8249(200004)47:4<430::aid-ana5>3.0.co;2-i}, pmid = {10762153}, url = {https://doi.org/10.1002/1531-8249(200004)47:4<430::aid-ana5>3.0.co;2-i} } @article{wachterman2016-27367547, author = {Wachterman, M. W. and Pilver, C. and Smith, D. and Ersek, M. and Lipsitz, SR. and Keating, N. L.}, title = {{Quality of End-of-Life Care Provided to Patients With Different Serious Illnesses}}, journal = {JAMA internal medicine}, year = {2016}, doi = {10.1001/jamainternmed.2016.1200}, pmid = {27367547}, url = {https://doi.org/10.1001/jamainternmed.2016.1200} } @article{cash2013-24049139, author = {Cash, D. M. and Ridgway, G. R. and Liang, Y. and Ryan, N. S. and Kinnunen, K. M. and Yeatman, T. and Malone, I. B. and Benzinger, T. L. and others}, title = {{The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study}}, journal = {Neurology}, year = {2013}, doi = {10.1212/wnl.0b013e3182a841c6}, pmid = {24049139}, url = {https://doi.org/10.1212/wnl.0b013e3182a841c6} } @article{levine2018-28605446, author = {Levine, D. M. and Lipsitz, SR. and Linder, J. A.}, title = {{Changes in Everyday and Digital Health Technology Use Among Seniors in Declining Health}}, journal = {The journals of gerontology. Series A, Biological sciences and medical sciences}, year = {2018}, doi = {10.1093/gerona/glx116}, pmid = {28605446}, url = {https://doi.org/10.1093/gerona/glx116} } @article{heneka2025-39653749, author = {Heneka, M. T. and van der Flier, W. M. and Jessen, F. and Hoozemanns, J. and Thal, D. R. and Boche, D. and Brosseron, F. and Teunissen, C. and others}, title = {{Neuroinflammation in Alzheimer disease}}, journal = {Nature reviews. Immunology}, year = {2025}, doi = {10.1038/s41577-024-01104-7}, pmid = {39653749}, url = {https://doi.org/10.1038/s41577-024-01104-7} } @article{orkaby2016-28039854, author = {Orkaby, Ariela R. and Ozonoff, Al and Reisman, Joel I. and Miller, Donald Ray and Zhao, Shibei and Rose, Adam J.}, title = {{Continued Use of Warfarin in Veterans with Atrial Fibrillation After Dementia Diagnosis}}, journal = {Journal of the American Geriatrics Society}, year = {2016}, doi = {10.1111/jgs.14573}, pmid = {28039854}, url = {https://doi.org/10.1111/jgs.14573} } @article{scheuner1996-8705854, author = {Scheuner, Donalyn and Eckman, Christopher B. and Jensen, M. and Song, X.H. and Citron, Martin and Suzuki, Nobuhiro and Bird, Thomas D. and Hardy, John and Hutton, Melanie L. and Kukull, Walter A. and Larson, Eric B. and Levy‐Lahad, Ephrat and Viitanen, Matti H. and Peskind, Elaine R. and Poorkaj, Parvoneh and Schellenberg, Gerald D. and Tanzi, Rudolph E. and Wasco, Wilma and Lannfelt, Lars and Selkoe, Dennis J. and Younkin, Samuel G.}, title = {{Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease}}, journal = {Nature Medicine}, year = {1996}, doi = {10.1038/nm0896-864}, pmid = {8705854}, url = {https://doi.org/10.1038/nm0896-864} } @article{dubois2016-27012484, author = {Dubois, Bruno and Hampel, Harald Juergen and Feldman, Howard and Scheltens, Philip and Aisen, Paul S. S. and Andrieu, Sandrine and Bakardjian, Hovagim and Benali, Habib and Bertram, Lars and Blennow, Kaj and Broich, Karl and Cavedo, Enrica and Crutch, Sebastian James and Dartigues, Jean‐François and Duyckaerts, Charles J. and Epelbaum, Stéphane and Frisoni, Giovanni Battista and Gauthier, Serge G. and Genthon, Rémy and Gouw, Alida A. and Habert, Marie‐Odile and Holtzman, David M. and Kivipelto, Miia and Lista, Simone and Molinuevo, José Luís and O’Bryant, Sid E. and Rabinovici, Gil D. and Rowe, Christopher Cleon and Salloway, Stephen and Schneider, Lon S. S. and Sperling, Reisa Anne and Teichmann, Marc and Carrillo, María C. and Cummings, Jeffrey L. and Jack, Clifford R.}, title = {{Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria}}, journal = {Alzheimer s \& Dementia}, year = {2016}, doi = {10.1016/j.jalz.2016.02.002}, pmid = {27012484}, url = {https://doi.org/10.1016/j.jalz.2016.02.002} } @article{sperling2009-19640477, author = {Sperling, Reisa Anne and LaViolette, Peter S. and O’Keefe, Kelly and O’Brien, Jacqueline L. and Rentz, Dorene M. and Pihlajamaki, Maija M. and Marshall, Gad A. and Hyman, Bradley T. and Selkoe, Dennis J. and Hedden, Trey and Buckner, Randy Lee and Becker, John Alex and Johnson, Keith A.}, title = {{Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia}}, journal = {Neuron}, year = {2009}, doi = {10.1016/j.neuron.2009.07.003}, pmid = {19640477}, url = {https://doi.org/10.1016/j.neuron.2009.07.003} } @article{wolfe1999-10206644, author = {Wolfe, Michael S. and Xia, Weiming and Ostaszewski, Beth L. and Diehl, Thekla S. and Kimberly, William Taylor and Selkoe, Dennis J.}, title = {{Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity}}, journal = {Nature}, year = {1999}, doi = {10.1038/19077}, pmid = {10206644}, url = {https://doi.org/10.1038/19077} } @article{ghanbarian2025-41268784, author = {Ghanbarian, E. and Qian, T. and Khorsand, B. and Zheng, L. and Sajjadi, S. A. and Grill, J. D. and Rabin, L. A. and Lipton, R. B. and Sperling, R. A. and Ezzati, A.}, title = {{Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70948}, pmid = {41268784}, url = {https://doi.org/10.1002/alz.70948} } @article{amariglio2020-32417775, author = {Amariglio, R. E. and Buckley, R. F. and Rabin, J. S. and Papp, K. V. and Quiroz, Y. T. and Mormino, E. C. and Sparks, K. P. and Johnson, K. A. and others}, title = {{Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2020}, doi = {10.3233/jad-191291}, pmid = {32417775}, url = {https://doi.org/10.3233/jad-191291} } @article{buckley2018-29803541, author = {Buckley, R. F. and Mormino, E. C. and Amariglio, R. E. and Properzi, M. J. and Rabin, J. S. and Lim, Y. Y. and Papp, K. V. and Jacobs, H. I. L. and others}, title = {{Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2018}, doi = {10.1016/j.jalz.2018.04.010}, pmid = {29803541}, url = {https://doi.org/10.1016/j.jalz.2018.04.010} } @article{black2010-20505438, author = {Black, R. S. and Sperling, R. A. and Safirstein, B. and Motter, R. N. and Pallay, A. and Nichols, A. and Grundman, M.}, title = {{A single ascending dose study of bapineuzumab in patients with Alzheimer disease}}, journal = {Alzheimer disease and associated disorders}, year = {2010}, doi = {10.1097/wad.0b013e3181c53b00}, pmid = {20505438}, url = {https://doi.org/10.1097/wad.0b013e3181c53b00} } @article{jack2011-21514247, author = {Jack, C. R. and Albert, M. S. and Knopman, D. S. and McKhann, G. M. and Sperling, R. A. and Carrillo, M. C. and Thies, B. and Phelps, C. H.}, title = {{Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2011}, doi = {10.1016/j.jalz.2011.03.004}, pmid = {21514247}, url = {https://doi.org/10.1016/j.jalz.2011.03.004} } @article{marshall2011-21575871, author = {Marshall, G. A. and Rentz, D. M. and Frey, M. T. and Locascio, J. J. and Johnson, K. A. and Sperling, R. A. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2011}, doi = {10.1016/j.jalz.2010.04.005}, pmid = {21575871}, url = {https://doi.org/10.1016/j.jalz.2010.04.005} } @article{conway1998-9809558, author = {Conway, K. A. and Harper, J. D. and Lansbury, P. T.}, title = {{Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease}}, journal = {Nature medicine}, year = {1998}, doi = {10.1038/3311}, pmid = {9809558}, url = {https://doi.org/10.1038/3311} } @article{wang2016-27348499, author = {Wang, W. and Wang, L. and Lu, J. and Siedlak, S. L. and Fujioka, H. and Liang, J. and Jiang, S. and Ma, X. and others}, title = {{The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity}}, journal = {Nature medicine}, year = {2016}, doi = {10.1038/nm.4130}, pmid = {27348499}, url = {https://doi.org/10.1038/nm.4130} } @article{jay2015-25732305, author = {Jay, T. R. and Miller, C. M. and Cheng, P. J. and Graham, L. C. and Bemiller, S. and Broihier, M. L. and Xu, G. and Margevicius, D. and others}, title = {{TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models}}, journal = {The Journal of experimental medicine}, year = {2015}, doi = {10.1084/jem.20142322}, pmid = {25732305}, url = {https://doi.org/10.1084/jem.20142322} } @article{rabinovici2025-40155270, author = {Rabinovici, G. D. and Selkoe, D. J. and Schindler, S. E. and Aisen, P. and Apostolova, L. G. and Atri, A. and Greenberg, S. M. and Hendrix, S. B. and others}, title = {{Donanemab: Appropriate use recommendations}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100150}, pmid = {40155270}, url = {https://doi.org/10.1016/j.tjpad.2025.100150} } @article{liss2021-33458891, author = {Liss, J. L. and Seleri Assunção, S. and Cummings, J. and Atri, A. and Geldmacher, D. S. and Candela, S. F. and Devanand, D. P. and Fillit, H. M. and others}, title = {{Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis}}, journal = {Journal of internal medicine}, year = {2021}, doi = {10.1111/joim.13244}, pmid = {33458891}, url = {https://doi.org/10.1111/joim.13244} } @article{mayerhofer2023-37360335, author = {Mayerhofer, Ernst and Zaba, Natalie O. and Parodi, Livia and Ganbold, Alena and Biffi, Alessandro and Rosand, Jonathan M. and Yechoor, Nirupama and Anderson, Christopher D.}, title = {{Disparities in brain health comorbidity management in intracerebral hemorrhage}}, journal = {Frontiers in Neurology}, year = {2023}, doi = {10.3389/fneur.2023.1194810}, pmid = {37360335}, url = {https://doi.org/10.3389/fneur.2023.1194810} } @article{selkoe2001-11274343, author = {Selkoe, Dennis J.}, title = {{Alzheimer's Disease: Genes, Proteins, and Therapy}}, journal = {Physiological Reviews}, year = {2001}, doi = {10.1152/physrev.2001.81.2.741}, pmid = {11274343}, url = {https://doi.org/10.1152/physrev.2001.81.2.741} } @article{dickerson2008-18632739, author = {Dickerson, Bradford Clark and Bakkour, Akram and Salat, David H. and Feczko, Eric and Pacheco, Jenni and Greve, Douglas N. and Grodstein, Fran and Wright, Christopher Ian and Blacker, Deborah and Rosas, Herminia Diana and Sperling, Reisa Anne and Atri, Alireza and Growdon, John H. and Hyman, Bradley T. and Morris, John C. and Fischl, Bruce R. and Buckner, Randy Lee}, title = {{The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals}}, journal = {Cerebral Cortex}, year = {2008}, doi = {10.1093/cercor/bhn113}, pmid = {18632739}, url = {https://doi.org/10.1093/cercor/bhn113} } @article{haass1992-1383826, author = {Haass, Christian and Schlossmacher, Michael G. and Hung, Albert Y. and Vigo‐Pelfrey, Carmen and Mellon, Angela and Ostaszewski, Beth L. and Lieberburg, Ivan M. and Koo, Edward H. and Schenk, Dale and Teplow, David B. and Selkoe, Dennis J.}, title = {{Amyloid β-peptide is produced by cultured cells during normal metabolism}}, journal = {Nature}, year = {1992}, doi = {10.1038/359322a0}, pmid = {1383826}, url = {https://doi.org/10.1038/359322a0} } @article{citron1992-1465129, author = {Citron, Martin and Oltersdorf, Tilman and Haass, Christian and McConlogue, Lisa and Hung, Albert Y. and Seubert, Peter A. and Vigo‐Pelfrey, Carmen and Lieberburg, Ivan M. and Selkoe, Dennis J.}, title = {{Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production}}, journal = {Nature}, year = {1992}, doi = {10.1038/360672a0}, pmid = {1465129}, url = {https://doi.org/10.1038/360672a0} } @article{caviedes2026-41688826, author = {Caviedes, A. and Cabral-Miranda, F. and Orellana, P. and Hernández, H. and Henríquez, F. and Gonzalez-Gomez, R. and Pizarro, M. and Migeot, J. and Ochoa-Rosales, C. and Gonzalez-Silva, C. and Marin-Diaz, N. and Coronel-Oliveros, C. and others}, title = {{Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America}}, journal = {Nature Aging}, year = {2026}, doi = {10.1038/s43587-025-01061-3}, pmid = {41688826}, url = {https://doi.org/10.1038/s43587-025-01061-3} } @article{ali2023-37101235, author = {Ali, M. and Archer, D. B. and Gorijala, P. and Western, D. and Timsina, J. and Fernández, M. V. and Wang, T. C. and Satizabal, C. L. and others}, title = {{Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease}}, journal = {Acta neuropathologica communications}, year = {2023}, doi = {10.1186/s40478-023-01563-4}, pmid = {37101235}, url = {https://doi.org/10.1186/s40478-023-01563-4} } @article{shulman2013-23836404, author = {Shulman, J. M. and Chen, K. and Keenan, B. T. and Chibnik, L. B. and Fleisher, A. and Thiyyagura, P. and Roontiva, A. and McCabe, C. and others}, title = {{Genetic susceptibility for Alzheimer disease neuritic plaque pathology}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.2815}, pmid = {23836404}, url = {https://doi.org/10.1001/jamaneurol.2013.2815} } @article{gomperts2008-18794492, author = {Gomperts, S. N. and Rentz, D. M. and Moran, E. and Becker, J. A. and Locascio, J. J. and Klunk, W. E. and Mathis, C. A. and Elmaleh, D. R. and others}, title = {{Imaging amyloid deposition in Lewy body diseases}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000326146.60732.d6}, pmid = {18794492}, url = {https://doi.org/10.1212/01.wnl.0000326146.60732.d6} } @article{drzezga2011-21490054, author = {Drzezga, A. and Becker, J. A. and Van Dijk, K. R. and Sreenivasan, A. and Talukdar, T. and Sullivan, C. and Schultz, A. P. and Sepulcre, J. and others}, title = {{Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden}}, journal = {Brain : a journal of neurology}, year = {2011}, doi = {10.1093/brain/awr066}, pmid = {21490054}, url = {https://doi.org/10.1093/brain/awr066} } @article{mcdonald2010-20403962, author = {Mc Donald, J. M. and Savva, G. M. and Brayne, C. and Welzel, A. T. and Forster, G. and Shankar, G. M. and Selkoe, D. J. and Ince, P. G. and others}, title = {{The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia}}, journal = {Brain : a journal of neurology}, year = {2010}, doi = {10.1093/brain/awq065}, pmid = {20403962}, url = {https://doi.org/10.1093/brain/awq065} } @article{hanseeuw2018-29792874, author = {Hanseeuw, B. J. and Betensky, R. A. and Mormino, E. C. and Schultz, A. P. and Sepulcre, J. and Becker, J. A. and Jacobs, H. I. L. and Buckley, R. F. and others}, title = {{PET staging of amyloidosis using striatum}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2018}, doi = {10.1016/j.jalz.2018.04.011}, pmid = {29792874}, url = {https://doi.org/10.1016/j.jalz.2018.04.011} } @article{sun2023-36379419, author = {Sun, Y. and Chen, C. and Yu, Y. and Zhang, H. and Tan, X. and Zhang, J. and Qi, L. and Lu, Y. and others}, title = {{Replacement of leisure-time sedentary behavior with various physical activities and the risk of dementia incidence and mortality: A prospective cohort study}}, journal = {Journal of sport and health science}, year = {2023}, doi = {10.1016/j.jshs.2022.11.005}, pmid = {36379419}, url = {https://doi.org/10.1016/j.jshs.2022.11.005} } @article{liu2025-40855194, author = {Liu, Yuxi and Gu, Xiao and Li, Yanping and Wang, Fenglei and Vyas, Chirag M. and Peng, Cheng and Dong, Danyue and Li, Yuhan and others}, title = {{Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function}}, journal = {Nature Medicine}, year = {2025}, doi = {10.1038/s41591-025-03891-5}, pmid = {40855194}, url = {https://doi.org/10.1038/s41591-025-03891-5} } @article{li2026-41535386, author = {Li, Jun and Hu, Jie and Yun, Huan and Mei, Zhendong and Wang, Xingyan and Luo, Kai and Guasch‐Ferré, Marta and Han, Xikun and others}, title = {{Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes}}, journal = {Nature Medicine}, year = {2026}, doi = {10.1038/s41591-025-04105-8}, pmid = {41535386}, url = {https://doi.org/10.1038/s41591-025-04105-8} } @article{liu2025-39903689, author = {Liu, Haiyan and Marsh, Thomas W. and Shi, Xinyu and Renton, Alan Edward and Bowling, Kevin M. and Ziegemeier, Ellen and Wang, Guoqiao and Cao, Yuchen and others}, title = {{The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset}}, journal = {Brain}, year = {2025}, doi = {10.1093/brain/awaf038}, pmid = {39903689}, url = {https://doi.org/10.1093/brain/awaf038} } @article{wang2025-41299092, author = {Wang, Yunhe and Xiao, Sihao and Liu, Bowen and Jiang, Rongtao and Liu, Yuxi and Hang, Yian and Chen, Li and Chen, Runsen and others}, title = {{Organ-specific proteomic aging clocks predict disease and longevity across diverse populations}}, journal = {Nature Aging}, year = {2025}, doi = {10.1038/s43587-025-01016-8}, pmid = {41299092}, url = {https://doi.org/10.1038/s43587-025-01016-8} } @article{cruchaga2013-23562540, author = {Cruchaga, Carlos C and Kauwe, John S. K. and Harari, Oscar and Jin, Sheng Chih and Cai, Yefei and Karch, Celeste M M. and Benítez, Bruno A. and Jeng, Amanda T. and Skorupa, Tara and Carrell, David and Bertelsen, Sarah E. and Bailey, Matthew H. and McKean, David M. and Shulman, Joshua M and De Jager, Philip L. and Chibnik, Lori Beth and Bennett, David and Arnold, S. E. and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Williams, Julie H. and Van Deerlin, Vivianna M. and Lee, Virginia M.‐Y. and Shaw, Leslie M. and Trojanowski, John Q. and Haines, Jonathan L. and Mayeux, Richard P and Pericak‐Vance, Margaret A. and Farrer, Lindsay A. and Schellenberg, Gerard D. and Peskind, Elaine R. and Galasko, Douglas R and Fagan, Anne M. and Holtzman, David M. and Morris, John C. and Goate, Alison}, title = {{GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease}}, journal = {Neuron}, year = {2013}, doi = {10.1016/j.neuron.2013.02.026}, pmid = {23562540}, url = {https://doi.org/10.1016/j.neuron.2013.02.026} } @article{kurniansyah2026-42661068, author = {Kurniansyah, N. and Tasaki, S. and Rehman, H. and Zhu, C. and Farrell, J. and Sherva, R. and Hauger, R. and Merritt, V. C. and Panizzon, M. and Zhang, R. and Gaziano, J. M. and Gim, J. and others}, title = {{A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations}}, journal = {Nature genetics}, year = {2026}, doi = {10.1038/s41588-026-02722-8}, pmid = {42661068}, url = {https://doi.org/10.1038/s41588-026-02722-8} } @article{therriault2024-38429551, author = {Therriault, J. and Schindler, S. E. and Salvadó, G. and Pascoal, T. A. and Benedet, A. L. and Ashton, N. J. and Karikari, T. K. and Apostolova, L. and others}, title = {{Biomarker-based staging of Alzheimer disease: rationale and clinical applications}}, journal = {Nature reviews. Neurology}, year = {2024}, doi = {10.1038/s41582-024-00942-2}, pmid = {38429551}, url = {https://doi.org/10.1038/s41582-024-00942-2} } @article{grill2024-38585443, author = {Grill, J. D. and Raman, R. and Ernstrom, K. and Wang, S. and Donohue, M. C. and Aisen, P. S. and Karlawish, J. and Henley, D. and others}, title = {{Immediate Reactions to Alzheimer Biomarker Disclosure in Cognitively Unimpaired Individuals in a Global Truncated Randomized Trial}}, journal = {Neurology. Clinical practice}, year = {2024}, doi = {10.1212/cpj.0000000000200265}, pmid = {38585443}, url = {https://doi.org/10.1212/cpj.0000000000200265} } @article{sperling2014-24648338, author = {Sperling, R. A. and Rentz, D. M. and Johnson, K. A. and Karlawish, J. and Donohue, M. and Salmon, D. P. and Aisen, P.}, title = {{The A4 study: stopping AD before symptoms begin?}}, journal = {Science translational medicine}, year = {2014}, doi = {10.1126/scitranslmed.3007941}, pmid = {24648338}, url = {https://doi.org/10.1126/scitranslmed.3007941} } @article{fong2015-26139023, author = {Fong, T. G. and Davis, D. and Growdon, M. E. and Albuquerque, A. and Inouye, S. K.}, title = {{The interface between delirium and dementia in elderly adults}}, journal = {The Lancet. Neurology}, year = {2015}, doi = {10.1016/s1474-4422(15)00101-5}, pmid = {26139023}, url = {https://doi.org/10.1016/s1474-4422(15)00101-5} } @article{fleisher2013-22633529, author = {Fleisher, A. S. and Chen, K. and Liu, X. and Ayutyanont, N. and Roontiva, A. and Thiyyagura, P. and Protas, H. and Joshi, A. D. and others}, title = {{Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease}}, journal = {Neurobiology of aging}, year = {2013}, doi = {10.1016/j.neurobiolaging.2012.04.017}, pmid = {22633529}, url = {https://doi.org/10.1016/j.neurobiolaging.2012.04.017} } @article{rentz2021-33589537, author = {Rentz, D. M. and Papp, K. V. and Mayblyum, D. V. and Sanchez, J. S. and Klein, H. and Souillard-Mandar, W. and Sperling, R. A. and Johnson, K. A.}, title = {{Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011697}, pmid = {33589537}, url = {https://doi.org/10.1212/wnl.0000000000011697} } @article{mazaheri2017-28483841, author = {Mazaheri, F. and Snaidero, N. and Kleinberger, G. and Madore, C. and Daria, A. and Werner, G. and Krasemann, S. and Capell, A. and others}, title = {{TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury}}, journal = {EMBO reports}, year = {2017}, doi = {10.15252/embr.201743922}, pmid = {28483841}, url = {https://doi.org/10.15252/embr.201743922} } @article{donovan2014-24698445, author = {Donovan, N. J. and Amariglio, R. E. and Zoller, A. S. and Rudel, R. K. and Gomez-Isla, T. and Blacker, D. and Hyman, B. T. and Locascio, J. J. and others}, title = {{Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2014}, doi = {10.1016/j.jagp.2014.02.007}, pmid = {24698445}, url = {https://doi.org/10.1016/j.jagp.2014.02.007} } @article{donovan2014-23890751, author = {Donovan, N. J. and Wadsworth, L. P. and Lorius, N. and Locascio, J. J. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and Marshall, G. A. and others}, title = {{Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2014}, doi = {10.1016/j.jagp.2013.03.006}, pmid = {23890751}, url = {https://doi.org/10.1016/j.jagp.2013.03.006} } @article{pase2017-28835407, author = {Pase, M. P. and Himali, J. J. and Grima, N. A. and Beiser, A. S. and Satizabal, C. L. and Aparicio, H. J. and Thomas, R. J. and Gottlieb, D. J. and others}, title = {{Sleep architecture and the risk of incident dementia in the community}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004373}, pmid = {28835407}, url = {https://doi.org/10.1212/wnl.0000000000004373} } @article{gao2023-36808743, author = {Gao, L. and Li, P. and Gaykova, N. and Zheng, X. and Gao, C. and Lane, J. M. and Saxena, R. and Scheer, F. A. J. L. and others}, title = {{Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia}}, journal = {Annals of neurology}, year = {2023}, doi = {10.1002/ana.26617}, pmid = {36808743}, url = {https://doi.org/10.1002/ana.26617} } @article{roy2020-31917687, author = {Roy, E. R. and Wang, B. and Wan, Y. W. and Chiu, G. and Cole, A. and Yin, Z. and Propson, N. E. and Xu, Y. and others}, title = {{Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease}}, journal = {The Journal of clinical investigation}, year = {2020}, doi = {10.1172/jci133737}, pmid = {31917687}, url = {https://doi.org/10.1172/jci133737} } @article{bairamian2022-35248147, author = {Bairamian, D. and Sha, S. and Rolhion, N. and Sokol, H. and Dorothée, G. and Lemere, C. A. and Krantic, S.}, title = {{Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2022}, doi = {10.1186/s13024-022-00522-2}, pmid = {35248147}, url = {https://doi.org/10.1186/s13024-022-00522-2} } @article{rohatgi2025-41038644, author = {Rohatgi, Saurabh and Zhu, Shenghua and Calle, Esteban and Ford, Jeremy N. and Kozak, Benjamin M. and Chagui, Odette Ganem and Vejdani‐Jahromi, Maryam and Griffin, Harry R. and others}, title = {{Are Deep White Matter Hyperintensities Associated with Amyloid-Related Imaging Abnormalities in Patients with Alzheimer Disease Treated with Lecanemab?}}, journal = {American Journal of Neuroradiology}, year = {2025}, doi = {10.3174/ajnr.a8822}, pmid = {41038644}, url = {https://doi.org/10.3174/ajnr.a8822} } @article{aaronson2025-40249614, author = {Aaronson, Anna and Diaz, Adam and Ashford, Miriam Thiel and Jin, Chengshi and Tank, Rachana and Miller, Melanie Jayne and Kang, Jae Myeong and Manjavong, Manchumad and others}, title = {{Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis}}, journal = {JAMA Network Open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.5810}, pmid = {40249614}, url = {https://doi.org/10.1001/jamanetworkopen.2025.5810} } @article{brycesmith2025-41120751, author = {Bryce-Smith, Sam and Brown, Anna‐Leigh and Chien, Max Z. Y. J. and Dattilo, Dario and Mehta, Puja R. and Mattedi, Francesca and Barattucci, Simone and Mikheenko, Alla and others}, title = {{TDP-43 loss induces cryptic polyadenylation in ALS/FTD}}, journal = {Nature Neuroscience}, year = {2025}, doi = {10.1038/s41593-025-02050-w}, pmid = {41120751}, url = {https://doi.org/10.1038/s41593-025-02050-w} } @article{farris2003-12634421, author = {Farris, Wesley and Mansourian, Stefan and Chang, Yang and Lindsley, Loren D. and Eckman, Elizabeth A. and Frosch, Matthew P. and Eckman, Christopher B. and Tanzi, Rudolph E. and Selkoe, Dennis J. and Guénette, Suzanne Y.}, title = {{Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo}}, journal = {Proceedings of the National Academy of Sciences}, year = {2003}, doi = {10.1073/pnas.0230450100}, pmid = {12634421}, url = {https://doi.org/10.1073/pnas.0230450100} } @article{schoemaker2021-33627498, author = {Schoemaker, D. and Charidimou, A. and Zanon Zotin, M. C. and Raposo, N. and Johnson, K. A. and Sanchez, J. S. and Greenberg, S. M. and Viswanathan, A.}, title = {{Association of Memory Impairment With Concomitant Tau Pathology in Patients With Cerebral Amyloid Angiopathy}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011745}, pmid = {33627498}, url = {https://doi.org/10.1212/wnl.0000000000011745} } @article{growdon2015-25934852, author = {Growdon, M. E. and Schultz, A. P. and Dagley, A. S. and Amariglio, R. E. and Hedden, T. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and others}, title = {{Odor identification and Alzheimer disease biomarkers in clinically normal elderly}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001614}, pmid = {25934852}, url = {https://doi.org/10.1212/wnl.0000000000001614} } @article{anderson2006-16847063, author = {Anderson, J. P. and Walker, D. E. and Goldstein, J. M. and de Laat, R. and Banducci, K. and Caccavello, R. J. and Barbour, R. and Huang, J. and others}, title = {{Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease}}, journal = {The Journal of biological chemistry}, year = {2006}, doi = {10.1074/jbc.m600933200}, pmid = {16847063}, url = {https://doi.org/10.1074/jbc.m600933200} } @article{wolozin2019-31582840, author = {Wolozin, B. and Ivanov, P.}, title = {{Stress granules and neurodegeneration}}, journal = {Nature reviews. Neuroscience}, year = {2019}, doi = {10.1038/s41583-019-0222-5}, pmid = {31582840}, url = {https://doi.org/10.1038/s41583-019-0222-5} } @article{weiner2017-27931796, author = {Weiner, M. W. and Veitch, D. P. and Aisen, P. S. and Beckett, L. A. and Cairns, N. J. and Green, R. C. and Harvey, D. and Jack, C. R. and others}, title = {{The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.10.006}, pmid = {27931796}, url = {https://doi.org/10.1016/j.jalz.2016.10.006} } @article{park2023-37081148, author = {Park, M. D. and Reyes-Torres, I. and LeBerichel, J. and Hamon, P. and LaMarche, N. M. and Hegde, S. and Belabed, M. and Troncoso, L. and others}, title = {{TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer}}, journal = {Nature immunology}, year = {2023}, doi = {10.1038/s41590-023-01475-4}, pmid = {37081148}, url = {https://doi.org/10.1038/s41590-023-01475-4} } @article{devore2009-19474131, author = {Devore, E. E. and Grodstein, F. and van Rooij, F. J. and Hofman, A. and Rosner, B. and Stampfer, M. J. and Witteman, J. C. and Breteler, M. M.}, title = {{Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk}}, journal = {The American journal of clinical nutrition}, year = {2009}, doi = {10.3945/ajcn.2008.27037}, pmid = {19474131}, url = {https://doi.org/10.3945/ajcn.2008.27037} } @article{greenberg2020-31827267, author = {Greenberg, S. M. and Bacskai, B. J. and Hernandez-Guillamon, M. and Pruzin, J. and Sperling, R. and van Veluw, S. J.}, title = {{Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways}}, journal = {Nature reviews. Neurology}, year = {2020}, doi = {10.1038/s41582-019-0281-2}, pmid = {31827267}, url = {https://doi.org/10.1038/s41582-019-0281-2} } @article{lee2022-35173313, author = {Lee, H. G. and Wheeler, M. A. and Quintana, F. J.}, title = {{Function and therapeutic value of astrocytes in neurological diseases}}, journal = {Nature reviews. Drug discovery}, year = {2022}, doi = {10.1038/s41573-022-00390-x}, pmid = {35173313}, url = {https://doi.org/10.1038/s41573-022-00390-x} } @article{heidecker2025-40582710, author = {Heidecker, Bettina and Libby, Peter and Vassiliou, Vassilios S. and Roubille, François and Vardeny, Orly and Hassager, Christian and Gatzoulis, Michael Athanassios and Mamas, Mamas A. and others}, title = {{Vaccination as a new form of cardiovascular prevention: a European Society of Cardiology clinical consensus statement}}, journal = {European Heart Journal}, year = {2025}, doi = {10.1093/eurheartj/ehaf384}, pmid = {40582710}, url = {https://doi.org/10.1093/eurheartj/ehaf384} } @article{senff2025-40307407, author = {Senff, Jasper Rudolf and Tack, Reinier W. P. and Tan, Benjamin Yong‐Qiang and Prapiadou, Savvina and Kimball, Tamara N. and Ng, Sharon and Duskin, Jonathan A. and Shah-Ostrowski, Mark Jun and others}, title = {{Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort}}, journal = {Scientific Reports}, year = {2025}, doi = {10.1038/s41598-025-99246-8}, pmid = {40307407}, url = {https://doi.org/10.1038/s41598-025-99246-8} } @article{sperling2011-21784348, author = {Sperling, Reisa Anne and Jack, Clifford R. and Black, Sandra E. and Frosch, Matthew P. and Greenberg, Steven Mark and Hyman, Bradley T. and Scheltens, Philip and Carrillo, María C. and Thies, William H. and Bednar, Martin M. and Black, Ronald S. and Brashear, H. Robert and Grundman, Michael and Siemers, Eric and Feldman, Howard and Schindler, Rachel J.}, title = {{Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup}}, journal = {Alzheimer s \& Dementia}, year = {2011}, doi = {10.1016/j.jalz.2011.05.2351}, pmid = {21784348}, url = {https://doi.org/10.1016/j.jalz.2011.05.2351} } @article{xia2017-28241163, author = {Xia, C. and Makaretz, S. J. and Caso, C. and McGinnis, S. and Gomperts, S. N. and Sepulcre, J. and Gomez-Isla, T. and Hyman, B. T. and others}, title = {{Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2016.5755}, pmid = {28241163}, url = {https://doi.org/10.1001/jamaneurol.2016.5755} } @article{margeta2022-35977543, author = {Margeta, M. A. and Yin, Z. and Madore, C. and Pitts, K. M. and Letcher, S. M. and Tang, J. and Jiang, S. and Gauthier, C. D. and others}, title = {{Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma}}, journal = {Immunity}, year = {2022}, doi = {10.1016/j.immuni.2022.07.014}, pmid = {35977543}, url = {https://doi.org/10.1016/j.immuni.2022.07.014} } @article{replogle2015-25545807, author = {Replogle, J. M. and Chan, G. and White, C. C. and Raj, T. and Winn, P. A. and Evans, D. A. and Sperling, R. A. and Chibnik, L. B. and others}, title = {{A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology}}, journal = {Annals of neurology}, year = {2015}, doi = {10.1002/ana.24337}, pmid = {25545807}, url = {https://doi.org/10.1002/ana.24337} } @article{ogunmoroti2016-27792654, author = {Ogunmoroti, O. and Allen, N. B. and Cushman, M. and Michos, E. D. and Rundek, T. and Rana, J. S. and Blankstein, R. and Blumenthal, R. S. and others}, title = {{Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis}}, journal = {Journal of the American Heart Association}, year = {2016}, doi = {10.1161/jaha.116.003954}, pmid = {27792654}, url = {https://doi.org/10.1161/jaha.116.003954} } @article{atri2019-30704681, author = {Atri, A.}, title = {{The Alzheimer's Disease Clinical Spectrum: Diagnosis and Management}}, journal = {The Medical clinics of North America}, year = {2019}, doi = {10.1016/j.mcna.2018.10.009}, pmid = {30704681}, url = {https://doi.org/10.1016/j.mcna.2018.10.009} } @article{lanctot2017-29067350, author = {Lanctôt, K. L. and Amatniek, J. and Ancoli-Israel, S. and Arnold, S. E. and Ballard, C. and Cohen-Mansfield, J. and Ismail, Z. and Lyketsos, C. and others}, title = {{Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2017}, doi = {10.1016/j.trci.2017.07.001}, pmid = {29067350}, url = {https://doi.org/10.1016/j.trci.2017.07.001} } @article{lemere1996-8837617, author = {Lemere, C. A. and Lopera, F. and Kosik, K. S. and Lendon, C. L. and Ossa, J. and Saido, T. C. and Yamaguchi, H. and Ruiz, A. and others}, title = {{The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology}}, journal = {Nature medicine}, year = {1996}, doi = {10.1038/nm1096-1146}, pmid = {8837617}, url = {https://doi.org/10.1038/nm1096-1146} } @article{yang2017-28053038, author = {Yang, T. and Li, S. and Xu, H. and Walsh, D. M. and Selkoe, D. J.}, title = {{Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2017}, doi = {10.1523/jneurosci.1698-16.2016}, pmid = {28053038}, url = {https://doi.org/10.1523/jneurosci.1698-16.2016} } @article{fawzy2025-41345521, author = {Fawzy, Michael Elnemais and Wang, Sharon and Palmer, Phebe and Gatchel, Jennifer R. and Marshall, Gad A. and Gagliardi, Geoffroy Pierre and Vannini, Patrizia and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Association between anosognosia and neuropsychiatric symptoms in Alzheimer’s disease dementia patients}}, journal = {Scientific Reports}, year = {2025}, doi = {10.1038/s41598-025-29569-z}, pmid = {41345521}, url = {https://doi.org/10.1038/s41598-025-29569-z} } @article{ottesen2025-40359903, author = {Ottesen, Taylor D. and Xiang, Lingwei and Adler, Rachel and Holly, Kaitlyn E. and Clark, Clancy J. and Sepucha, Karen and Shah, Samir K. and Kim, Dae Hyun and others}, title = {{Patients With Moderate to Severe Dementia Who Undergo Elective TKA Face Elevated Risks of Death, Delirium, and Intensive Interventions: A Large, Propensity-weighted Database Study}}, journal = {Clinical Orthopaedics and Related Research}, year = {2025}, doi = {10.1097/corr.0000000000003542}, pmid = {40359903}, url = {https://doi.org/10.1097/corr.0000000000003542} } @article{selkoe1991-1673054, author = {Selkoe, Dennis J.}, title = {{The molecular pathology of Alzheimer's disease}}, journal = {Neuron}, year = {1991}, doi = {10.1016/0896-6273(91)90052-2}, pmid = {1673054}, url = {https://doi.org/10.1016/0896-6273(91)90052-2} } @article{jun2017-28183528, author = {Jun, G. R. and Chung, J. and Mez, J. and Barber, R. and Beecham, G. W. and Bennett, D. A. and Buxbaum, J. D. and Byrd, G. S. and others}, title = {{Transethnic genome-wide scan identifies novel Alzheimer's disease loci}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.12.012}, pmid = {28183528}, url = {https://doi.org/10.1016/j.jalz.2016.12.012} } @article{bennett2009-19398704, author = {Bennett, D. A. and De Jager, P. L. and Leurgans, S. E. and Schneider, J. A.}, title = {{Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181a2e87d}, pmid = {19398704}, url = {https://doi.org/10.1212/wnl.0b013e3181a2e87d} } @article{johnson2012-22474610, author = {Johnson, K. A. and Fox, N. C. and Sperling, R. A. and Klunk, W. E.}, title = {{Brain imaging in Alzheimer disease}}, journal = {Cold Spring Harbor perspectives in medicine}, year = {2012}, doi = {10.1101/cshperspect.a006213}, pmid = {22474610}, url = {https://doi.org/10.1101/cshperspect.a006213} } @article{rentz2011-21689670, author = {Rentz, D. M. and Amariglio, R. E. and Becker, J. A. and Frey, M. and Olson, L. E. and Frishe, K. and Carmasin, J. and Maye, J. E. and others}, title = {{Face-name associative memory performance is related to amyloid burden in normal elderly}}, journal = {Neuropsychologia}, year = {2011}, doi = {10.1016/j.neuropsychologia.2011.06.006}, pmid = {21689670}, url = {https://doi.org/10.1016/j.neuropsychologia.2011.06.006} } @article{cross2020-31609481, author = {Cross, S. H. and Kaufman, B. G. and Taylor, D. H. and Kamal, A. H. and Warraich, H. J.}, title = {{Trends and Factors Associated with Place of Death for Individuals with Dementia in the United States}}, journal = {Journal of the American Geriatrics Society}, year = {2020}, doi = {10.1111/jgs.16200}, pmid = {31609481}, url = {https://doi.org/10.1111/jgs.16200} } @article{liu2024-39158850, author = {Liu, L. and Saba, A. and Pascual, JR. and Miller, M. B. and Hennessey, E. L. and Lott, I. T. and Brickman, A. M. and Wilcock, D. M. and others}, title = {{Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.2579}, pmid = {39158850}, url = {https://doi.org/10.1001/jamaneurol.2024.2579} } @article{rabin2017-28482688, author = {Rabin, L. A. and Smart, C. M. and Amariglio, R. E.}, title = {{Subjective Cognitive Decline in Preclinical Alzheimer's Disease}}, journal = {Annual review of clinical psychology}, year = {2017}, doi = {10.1146/annurev-clinpsy-032816-045136}, pmid = {28482688}, url = {https://doi.org/10.1146/annurev-clinpsy-032816-045136} } @article{you2022-35029059, author = {You, Y. and Muraoka, S. and Jedrychowski, M. P. and Hu, J. and McQuade, A. K. and Young-Pearse, T. and Aslebagh, R. and Shaffer, S. A. and others}, title = {{Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain}}, journal = {Journal of extracellular vesicles}, year = {2022}, doi = {10.1002/jev2.12183}, pmid = {35029059}, url = {https://doi.org/10.1002/jev2.12183} } @article{leissring2003-14687544, author = {Leissring, M. A. and Farris, W. and Chang, A. Y. and Walsh, D. M. and Wu, X. and Sun, X. and Frosch, M. P. and Selkoe, D. J.}, title = {{Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death}}, journal = {Neuron}, year = {2003}, doi = {10.1016/s0896-6273(03)00787-6}, pmid = {14687544}, url = {https://doi.org/10.1016/s0896-6273(03)00787-6} } @article{lee1998-9623986, author = {Lee, S. J. and Liyanage, U. and Bickel, P. E. and Xia, W. and Lansbury, P. T. and Kosik, K. S.}, title = {{A detergent-insoluble membrane compartment contains A beta in vivo}}, journal = {Nature medicine}, year = {1998}, doi = {10.1038/nm0698-730}, pmid = {9623986}, url = {https://doi.org/10.1038/nm0698-730} } @article{bisht2016-26847266, author = {Bisht, K. and Sharma, K. P. and Lecours, C. and Sánchez, M. G. and El Hajj, H. and Milior, G. and Olmos-Alonso, A. and Gómez-Nicola, D. and others}, title = {{Dark microglia: A new phenotype predominantly associated with pathological states}}, journal = {Glia}, year = {2016}, doi = {10.1002/glia.22966}, pmid = {26847266}, url = {https://doi.org/10.1002/glia.22966} } @article{singh2023-38107629, author = {Singh, S. D. and Oreskovic, T. and Carr, S. and Papier, K. and Conroy, M. and Senff, JR. and Chemali, Z. and Gutierrez-Martinez, L. and others}, title = {{The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort}}, journal = {Frontiers in neurology}, year = {2023}, doi = {10.3389/fneur.2023.1291020}, pmid = {38107629}, url = {https://doi.org/10.3389/fneur.2023.1291020} } @article{mcgrath2019-30830941, author = {McGrath, E. R. and Himali, J. J. and Levy, D. and Conner, S. C. and Pase, M. P. and Abraham, C. R. and Courchesne, P. and Satizabal, C. L. and others}, title = {{Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study}}, journal = {PloS one}, year = {2019}, doi = {10.1371/journal.pone.0213321}, pmid = {30830941}, url = {https://doi.org/10.1371/journal.pone.0213321} } @article{buchman2016-26819457, author = {Buchman, A. S. and Yu, L. and Boyle, P. A. and Schneider, J. A. and De Jager, P. L. and Bennett, D. A.}, title = {{Higher brain BDNF gene expression is associated with slower cognitive decline in older adults}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000002387}, pmid = {26819457}, url = {https://doi.org/10.1212/wnl.0000000000002387} } @article{panayi2025-41497512, author = {Panayi, Adriana C. and Friedrich, Sarah and Rühl, Jasmin and Schaschinger, Thomas and Niederegger, Tobias and Knoedler, Leonard and Knoedler, Samuel and Rendenbach, Carsten and others}, title = {{Delirium after surgery: a retrospective study of predictors, complications, and screening patterns in the national surgical quality improvement program}}, journal = {EClinicalMedicine}, year = {2025}, doi = {10.1016/j.eclinm.2025.103629}, pmid = {41497512}, url = {https://doi.org/10.1016/j.eclinm.2025.103629} } @article{johnson2007-17683091, author = {Johnson, Keith A. and Gregas, Matt and Becker, John Alex and Kinnecom, Catherine and Salat, David H. and Moran, Erin K. and Smith, Eric Edward and Rosand, Jonathan M. and Rentz, Dorene M. and Klunk, William E. and Mathis, Chester A. and Price, Julie C. and DeKosky, Steven T. and Fischman, Alan J. and Greenberg, Steven Mark}, title = {{Imaging of amyloid burden and distribution in cerebral amyloid angiopathy}}, journal = {Annals of Neurology}, year = {2007}, doi = {10.1002/ana.21164}, pmid = {17683091}, url = {https://doi.org/10.1002/ana.21164} } @article{hampel2023-37280110, author = {Hampel, H. and Elhage, A. and Cho, M. and Apostolova, L. G. and Nicoll, J. A. R. and Atri, A.}, title = {{Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics}}, journal = {Brain : a journal of neurology}, year = {2023}, doi = {10.1093/brain/awad188}, pmid = {37280110}, url = {https://doi.org/10.1093/brain/awad188} } @article{yang2026-42410659, author = {Yang, C. T. and Wilkins, J. M. and Kesselheim, A. S. and Kim, D. H. and Lin, K. J.}, title = {{Clinical outcomes after antipsychotic discontinuation in nursing home residents with dementia: a nationwide cohort study}}, journal = {Alzheimer's Research \& Therapy}, year = {2026}, doi = {10.1186/s13195-026-02134-0}, pmid = {42410659}, url = {https://doi.org/10.1186/s13195-026-02134-0} } @article{jacobs2020-32273431, author = {Jacobs, H. I. L. and Augustinack, J. C. and Schultz, A. P. and Hanseeuw, B. J. and Locascio, J. and Amariglio, R. E. and Papp, K. V. and Rentz, D. M. and others}, title = {{The presubiculum links incipient amyloid and tau pathology to memory function in older persons}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009362}, pmid = {32273431}, url = {https://doi.org/10.1212/wnl.0000000000009362} } @article{sabuncu2012-22169231, author = {Sabuncu, M. R. and Buckner, R. L. and Smoller, J. W. and Lee, P. H. and Fischl, B. and Sperling, R. A. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects}}, journal = {Cerebral cortex (New York, N.Y. : 1991)}, year = {2012}, doi = {10.1093/cercor/bhr348}, pmid = {22169231}, url = {https://doi.org/10.1093/cercor/bhr348} } @article{ames2021-33546262, author = {Ames, B. N. and Grant, W. B. and Willett, W. C.}, title = {{Does the High Prevalence of Vitamin D Deficiency in African Americans Contribute to Health Disparities?}}, journal = {Nutrients}, year = {2021}, doi = {10.3390/nu13020499}, pmid = {33546262}, url = {https://doi.org/10.3390/nu13020499} } @article{rabin2015-26402085, author = {Rabin, L. A. and Smart, C. M. and Crane, P. K. and Amariglio, R. E. and Berman, L. M. and Boada, M. and Buckley, R. F. and Chételat, G. and others}, title = {{Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2015}, doi = {10.3233/jad-150154}, pmid = {26402085}, url = {https://doi.org/10.3233/jad-150154} } @article{alten2025-40028849, author = {Alten, B. and Gokcal, E. and Warren, A. and van Veluw, S. J. and Kozberg, M. and Gurol, M. E. and Viswanathan, A. and Greenberg, S. M.}, title = {{Cerebrospinal Fluid Beta-Amyloid Concentration and Clinical and Radiographic Manifestations of Cerebral Amyloid Angiopathy}}, journal = {Journal of the American Heart Association}, year = {2025}, doi = {10.1161/jaha.124.040025}, pmid = {40028849}, url = {https://doi.org/10.1161/jaha.124.040025} } @article{miner2026-42440317, author = {Miner, A. E. and Zetterberg, H. and Blennow, K. and Groh, JR. and Singh, A. and Dieckhoff, K. and Tripodis, Y. and Adler, C. H. and others}, title = {{Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy}}, journal = {JAMA network open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.22966}, pmid = {42440317}, url = {https://doi.org/10.1001/jamanetworkopen.2026.22966} } @article{itagaki1989-2808689, author = {Itagaki, S. and McGeer, P. L. and Akiyama, H. and Zhu, S. and Selkoe, D.}, title = {{Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease}}, journal = {Journal of neuroimmunology}, year = {1989}, doi = {10.1016/0165-5728(89)90115-x}, pmid = {2808689}, url = {https://doi.org/10.1016/0165-5728(89)90115-x} } @article{moscoso2025-11860bf1, author = {Moscoso, Alexis and Leuzy, Antoine and Raket, Lars Lau and Villemagne, Victor L. and Klein, Gregory and Tonietto, Matteo and Olafson, Emily and Baker, Suzanne L. and others}, title = {{External Validation of Joint Propagation Model‐Based Tau PET CenTauR units}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70856_106362}, url = {https://doi.org/10.1002/alz70856_106362} } @article{jung2025-40397431, author = {Jung, Kyungyeon and Kim, Ju Hwan and Bea, Sungho and Ko, Hwa Yeon and You, Seng Chan and Choi, Eue‐Keun and Lee, Suehyun and Lim, Minsik and others}, title = {{Association between sacubitril/valsartan and risk of dementia in patients with heart failure: a nationwide cohort study}}, journal = {European Heart Journal - Cardiovascular Pharmacotherapy}, year = {2025}, doi = {10.1093/ehjcvp/pvaf024}, pmid = {40397431}, url = {https://doi.org/10.1093/ehjcvp/pvaf024} } @article{huang2025-40624639, author = {Huang, Tianyi and Beydoun, May A. and Kianersi, Sina and Redline, Susan S and Launer, Lenore J.}, title = {{Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank}}, journal = {BMC Medicine}, year = {2025}, doi = {10.1186/s12916-025-04251-3}, pmid = {40624639}, url = {https://doi.org/10.1186/s12916-025-04251-3} } @article{schultz2023-37291760, author = {Schultz, S. A. and Shirzadi, Z. and Schultz, A. P. and Liu, L. and Fitzpatrick, C. D. and McDade, E. and Barthelemy, N. R. and Renton, A. and others}, title = {{Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease}}, journal = {Aging cell}, year = {2023}, doi = {10.1111/acel.13871}, pmid = {37291760}, url = {https://doi.org/10.1111/acel.13871} } @article{serranopozo2014-24585367, author = {Serrano-Pozo, A. and Qian, J. and Monsell, S. E. and Blacker, D. and Gómez-Isla, T. and Betensky, R. A. and Growdon, J. H. and Johnson, K. A. and others}, title = {{Mild to moderate Alzheimer dementia with insufficient neuropathological changes}}, journal = {Annals of neurology}, year = {2014}, doi = {10.1002/ana.24125}, pmid = {24585367}, url = {https://doi.org/10.1002/ana.24125} } @article{guskiewicz2005-16239884, author = {Guskiewicz, K. M. and Marshall, S. W. and Bailes, J. and McCrea, M. and Cantu, R. C. and Randolph, C. and Jordan, B. D.}, title = {{Association between recurrent concussion and late-life cognitive impairment in retired professional football players}}, journal = {Neurosurgery}, year = {2005}, doi = {10.1093/neurosurgery/57.4.719}, pmid = {16239884}, url = {https://doi.org/10.1093/neurosurgery/57.4.719} } @article{desikan2008-18672473, author = {Desikan, R. S. and Fischl, B. and Cabral, H. J. and Kemper, T. L. and Guttmann, C. R. and Blacker, D. and Hyman, B. T. and Albert, M. S. and others}, title = {{MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000320055.57329.34}, pmid = {18672473}, url = {https://doi.org/10.1212/01.wnl.0000320055.57329.34} } @article{volandes2008-18588408, author = {Volandes, A. E. and Paasche-Orlow, M. and Gillick, M. R. and Cook, E. F. and Shaykevich, S. and Abbo, E. D. and Lehmann, L.}, title = {{Health literacy not race predicts end-of-life care preferences}}, journal = {Journal of palliative medicine}, year = {2008}, doi = {10.1089/jpm.2007.0224}, pmid = {18588408}, url = {https://doi.org/10.1089/jpm.2007.0224} } @article{ewers2011-21696834, author = {Ewers, M. and Sperling, R. A. and Klunk, W. E. and Weiner, M. W. and Hampel, H.}, title = {{Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia}}, journal = {Trends in neurosciences}, year = {2011}, doi = {10.1016/j.tins.2011.05.005}, pmid = {21696834}, url = {https://doi.org/10.1016/j.tins.2011.05.005} } @article{mcdade2021-34548654, author = {McDade, E. and Voytyuk, I. and Aisen, P. and Bateman, R. J. and Carrillo, M. C. and De Strooper, B. and Haass, C. and Reiman, E. M. and others}, title = {{The case for low-level BACE1 inhibition for the prevention of Alzheimer disease}}, journal = {Nature reviews. Neurology}, year = {2021}, doi = {10.1038/s41582-021-00545-1}, pmid = {34548654}, url = {https://doi.org/10.1038/s41582-021-00545-1} } @article{gotzl2019-31122931, author = {Götzl, J. K. and Brendel, M. and Werner, G. and Parhizkar, S. and Sebastian Monasor, L. and Kleinberger, G. and Colombo, A. V. and Deussing, M. and others}, title = {{Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism}}, journal = {EMBO molecular medicine}, year = {2019}, doi = {10.15252/emmm.201809711}, pmid = {31122931}, url = {https://doi.org/10.15252/emmm.201809711} } @article{batista2024-38255891, author = {Batista, A. F. and Khan, K. A. and Papavergi, M. T. and Lemere, C. A.}, title = {{The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis}}, journal = {International journal of molecular sciences}, year = {2024}, doi = {10.3390/ijms25020817}, pmid = {38255891}, url = {https://doi.org/10.3390/ijms25020817} } @article{marriott2022-34978125, author = {Marriott, R. J. and Murray, K. and Flicker, L. and Hankey, G. J. and Matsumoto, A. M. and Dwivedi, G. and Antonio, L. and Almeida, O. P. and others}, title = {{Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2022}, doi = {10.1002/alz.12529}, pmid = {34978125}, url = {https://doi.org/10.1002/alz.12529} } @article{moscoso2025-41434902, author = {Moscoso, Alexis and Leuzy, Antoine and Raket, Lars Lau and Villemagne, Victor L. and Klein, Gregory and Tonietto, Matteo and Olafson, Emily and Baker, Suzanne L. and others}, title = {{External Validation of Joint Propagation Model‐Based Tau PET CenTauR units}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70862_109722}, pmid = {41434902}, url = {https://doi.org/10.1002/alz70862_109722} } @article{hazelton2025-41073365, author = {Hazelton, Jessica L. and Migeot, Joaquín and González-Gómez, Raúl and Altschuler, Florencia and Duran-Aniotz, Claudia A. and Wen, Olivia and Rial, Dante Sebastián Galván Galván and Barttfeld, Pablo and others}, title = {{Cardiovascular risk factors and the allostatic interoceptive network in dementia}}, journal = {Cardiovascular Research}, year = {2025}, doi = {10.1093/cvr/cvaf185}, pmid = {41073365}, url = {https://doi.org/10.1093/cvr/cvaf185} } @article{fried1991-1669507, author = {Fried, Linda P. and Borhani, Nemat O. and Enright, Paul and Furberg, Curt Daniel and Gardin, Julius M. and Kronmal, Richard A. and Kuller, Lewis H. and Manolio, Teri A. and Mittelmark, Maurice B. and Newman, Anne B. and O’Leary, Daniel H. and Psaty, Bruce M. and Rautaharju, Pentti M. and Tracy, Russell P. and Weiler, Philip G.}, title = {{The cardiovascular health study: Design and rationale}}, journal = {Annals of Epidemiology}, year = {1991}, doi = {10.1016/1047-2797(91)90005-w}, pmid = {1669507}, url = {https://doi.org/10.1016/1047-2797(91)90005-w} } @article{lemere1996-9173910, author = {Lemere, Cynthia Ann and Blusztajn, Jan Krzysztof and Yamaguchi, Hiroki and Wisniewski, Thomas and Saido, Takaomi C. and Selkoe, Dennis J.}, title = {{Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation}}, journal = {Neurobiology of Disease}, year = {1996}, doi = {10.1006/nbdi.1996.0003}, pmid = {9173910}, url = {https://doi.org/10.1006/nbdi.1996.0003} } @article{bateman2010-21a895c8, author = {Bateman, Randall John and Aisen, Paul S. S. and De Strooper, Bart and Fox, Nick C. and Lemere, Cynthia Ann and Ringman, John Matthew and Salloway, Stephen and Sperling, Reisa Anne and Windisch, Manfred and Xiong, Chengjie}, title = {{Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease}}, journal = {Alzheimer s Research \& Therapy}, year = {2010}, doi = {10.1186/alzrt59}, url = {https://doi.org/10.1186/alzrt59} } @article{beyrer2026-41926844, author = {Beyrer, J. and Sheff, Z. and Payakachat, N. and Chandler, J. M. and Chen, Y. F. and Kubisiak, J. and Lee, A. and Holdridge, K. C. and Yaari, R. and Aisen, P. and Rafii, M. S. and Sperling, R. A. and others}, title = {{Increase in healthcare utilization and Medicare payment with progression of preclinical Alzheimer's disease}}, journal = {Journal of Prevention of Alzheimer's Disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100547}, pmid = {41926844}, url = {https://doi.org/10.1016/j.tjpad.2026.100547} } @article{bonomi2024-38038976, author = {Bonomi, S. and Lu, R. and Schindler, S. E. and Bui, Q. and Lah, J. J. and Wolk, D. and Gleason, C. E. and Sperling, R. and others}, title = {{Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals}}, journal = {Annals of neurology}, year = {2024}, doi = {10.1002/ana.26838}, pmid = {38038976}, url = {https://doi.org/10.1002/ana.26838} } @article{rabin2019-30565287, author = {Rabin, J. S. and Yang, H. S. and Schultz, A. P. and Hanseeuw, B. J. and Hedden, T. and Viswanathan, A. and Gatchel, JR. and Marshall, G. A. and others}, title = {{Vascular Risk and β-Amyloid Are Synergistically Associated with Cortical Tau}}, journal = {Annals of neurology}, year = {2019}, doi = {10.1002/ana.25399}, pmid = {30565287}, url = {https://doi.org/10.1002/ana.25399} } @article{ismail2018-28899446, author = {Ismail, Z. and Gatchel, J. and Bateman, D. R. and Barcelos-Ferreira, R. and Cantillon, M. and Jaeger, J. and Donovan, N. J. and Mortby, M. E.}, title = {{Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria}}, journal = {International psychogeriatrics}, year = {2018}, doi = {10.1017/s1041610217001880}, pmid = {28899446}, url = {https://doi.org/10.1017/s1041610217001880} } @article{musen2012-22664957, author = {Musen, G. and Jacobson, A. M. and Bolo, N. R. and Simonson, D. C. and Shenton, M. E. and McCartney, R. L. and Flores, V. L. and Hoogenboom, W. S.}, title = {{Resting-state brain functional connectivity is altered in type 2 diabetes}}, journal = {Diabetes}, year = {2012}, doi = {10.2337/db11-1669}, pmid = {22664957}, url = {https://doi.org/10.2337/db11-1669} } @article{brass2006-17179895, author = {Brass, S. D. and Chen, N. K. and Mulkern, R. V. and Bakshi, R.}, title = {{Magnetic resonance imaging of iron deposition in neurological disorders}}, journal = {Topics in magnetic resonance imaging : TMRI}, year = {2006}, doi = {10.1097/01.rmr.0000245459.82782.e4}, pmid = {17179895}, url = {https://doi.org/10.1097/01.rmr.0000245459.82782.e4} } @article{varatharajah2019-30783207, author = {Varatharajah, Y. and Ramanan, V. K. and Iyer, R. and Vemuri, P. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics}}, journal = {Scientific reports}, year = {2019}, doi = {10.1038/s41598-019-38793-3}, pmid = {30783207}, url = {https://doi.org/10.1038/s41598-019-38793-3} } @article{volles2001-11425308, author = {Volles, M. J. and Lee, S. J. and Rochet, J. C. and Shtilerman, M. D. and Ding, T. T. and Kessler, J. C. and Lansbury, P. T.}, title = {{Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease}}, journal = {Biochemistry}, year = {2001}, doi = {10.1021/bi0102398}, pmid = {11425308}, url = {https://doi.org/10.1021/bi0102398} } @article{hemming2005-16154999, author = {Hemming, M. L. and Selkoe, D. J.}, title = {{Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m508460200}, pmid = {16154999}, url = {https://doi.org/10.1074/jbc.m508460200} } @article{kaul1999-10393974, author = {Kaul, M. and Lipton, S. A.}, title = {{Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1999}, doi = {10.1073/pnas.96.14.8212}, pmid = {10393974}, url = {https://doi.org/10.1073/pnas.96.14.8212} } @article{oveisgharan2025-40845264, author = {Oveisgharan, Shahram and Yu, Lei and Yang, Jingyun and Agrawal, Sonal and Vialle, Ricardo A. and Lopes, Kátia de Paiva and Tasaki, Shinya and Wang, Yanling and others}, title = {{Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000214024}, pmid = {40845264}, url = {https://doi.org/10.1212/wnl.0000000000214024} } @article{li2026-42015324, author = {Li, Runpeng and Langford, Oliver and Insel, Philip S. and Sperling, Reisa Anne and Raman, Rema and Aisen, Paul S. S and Donohue, Michael}, title = {{Divergent patterns of cognitive decline in preclinical Alzheimer's disease: Implications for secondary prevention trials}}, journal = {Alzheimer s \& Dementia}, year = {2026}, doi = {10.1002/alz.71366}, pmid = {42015324}, url = {https://doi.org/10.1002/alz.71366} } @article{huynh2026-41569280, author = {Huynh, Andrew L. H. and Wang, Shunran and Lee, Kathryn and Amadoru, Sanka and Wrigley, Scott D. and Zisis, Georgios and Ernstrom, Karin B. and RAMAN, REMA and others}, title = {{Prevalence of frailty and its association with cognition in preclinical Alzheimer’s disease: a cross-sectional analysis of baseline data from the A4 study}}, journal = {Age and Ageing}, year = {2026}, doi = {10.1093/ageing/afaf378}, pmid = {41569280}, url = {https://doi.org/10.1093/ageing/afaf378} } @article{wu2025-41449636, author = {Wu, Jiageng and Wyss, Richard and Lin, Josh C. H. and Yang, Jie}, title = {{Cognitive Assessment of Dementia Patients Using Large Language Models}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70858_103769}, pmid = {41449636}, url = {https://doi.org/10.1002/alz70858_103769} } @article{wang2025-40537069, author = {Wang, Shuyue and Zhang, Fan and Zeng, Qingze and Hong, Hui and Zhang, Yao and Xie, Linyun and Miao, Lin and Jiaerken, Yeerfan and others}, title = {{Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213666}, pmid = {40537069}, url = {https://doi.org/10.1212/wnl.0000000000213666} } @article{daniels2026-41709913, author = {Daniels, Alisha J. and McDade, Eric and Llibre‐Guerra, Jorge J. and Xiong, Chengjie and Perrin, Richard J. and Ibáñez, Laura and Supnet‐Bell, Charlene and Cruchaga, Carlos C and others}, title = {{15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN}}, journal = {npj Dementia}, year = {2026}, doi = {10.1038/s44400-025-00047-7}, pmid = {41709913}, url = {https://doi.org/10.1038/s44400-025-00047-7} } @article{matar2026-42200480, author = {Matar, Dany Y. and Lee, John J. and Niederegger, Tobias and Tee, Jia Wei and Schaschinger, Thomas and Orgill, Dennis Paul and Hundeshagen, Gabriel and Panayi, Adriana Christine}, title = {{Dementia and postoperative outcomes in older adults: national estimates and mechanistic pathways from a US cohort study}}, journal = {Age and Ageing}, year = {2026}, doi = {10.1093/ageing/afag155}, pmid = {42200480}, url = {https://doi.org/10.1093/ageing/afag155} } @article{grober2022-35197359, author = {Grober, E. and Lipton, R. B. and Sperling, R. A. and Papp, K. V. and Johnson, K. A. and Rentz, D. M. and Veroff, A. E. and Aisen, P. S. and others}, title = {{Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200046}, pmid = {35197359}, url = {https://doi.org/10.1212/wnl.0000000000200046} } @article{maron2009-18729731, author = {Maron, B. A. and Loscalzo, J.}, title = {{The treatment of hyperhomocysteinemia}}, journal = {Annual review of medicine}, year = {2009}, doi = {10.1146/annurev.med.60.041807.123308}, pmid = {18729731}, url = {https://doi.org/10.1146/annurev.med.60.041807.123308} } @article{klunk2002-12230326, author = {Klunk, W. E. and Bacskai, B. J. and Mathis, C. A. and Kajdasz, S. T. and McLellan, M. E. and Frosch, M. P. and Debnath, M. L. and Holt, D. P. and others}, title = {{Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative}}, journal = {Journal of neuropathology and experimental neurology}, year = {2002}, doi = {10.1093/jnen/61.9.797}, pmid = {12230326}, url = {https://doi.org/10.1093/jnen/61.9.797} } @article{resnick1989-2909873, author = {Resnick, N. M. and Yalla, S. V. and Laurino, E.}, title = {{The pathophysiology of urinary incontinence among institutionalized elderly persons}}, journal = {The New England journal of medicine}, year = {1989}, doi = {10.1056/nejm198901053200101}, pmid = {2909873}, url = {https://doi.org/10.1056/nejm198901053200101} } @article{stern2023-cdf6b8dd, author = {Stern, A. M. and Van Pelt, K. L. and Liu, L. and Anderson, A. K. and Ostaszewski, B. and Mapstone, M. and O’Bryant, S. and Petersen, M. E. and others}, title = {{Plasma NT1-tau and Aβ42correlate with age and cognitive function in two large Down syndrome cohorts}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1101/2023.03.10.23287109}, url = {https://doi.org/10.1101/2023.03.10.23287109} } @article{shen2007-17197420, author = {Shen, J. and Kelleher, R. J.}, title = {{The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2007}, doi = {10.1073/pnas.0608332104}, pmid = {17197420}, url = {https://doi.org/10.1073/pnas.0608332104} } @article{rogers1999-10037734, author = {Rogers, J. T. and Leiter, L. M. and McPhee, J. and Cahill, C. M. and Zhan, S. S. and Potter, H. and Nilsson, L. N.}, title = {{Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences}}, journal = {The Journal of biological chemistry}, year = {1999}, doi = {10.1074/jbc.274.10.6421}, pmid = {10037734}, url = {https://doi.org/10.1074/jbc.274.10.6421} } @article{dong2009-19433662, author = {Dong, Y. and Zhang, G. and Zhang, B. and Moir, R. D. and Xia, W. and Marcantonio, E. R. and Culley, D. J. and Crosby, G. and others}, title = {{The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels}}, journal = {Archives of neurology}, year = {2009}, doi = {10.1001/archneurol.2009.48}, pmid = {19433662}, url = {https://doi.org/10.1001/archneurol.2009.48} } @article{hemming2008-18942891, author = {Hemming, M. L. and Elias, J. E. and Gygi, S. P. and Selkoe, D. J.}, title = {{Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements}}, journal = {PLoS biology}, year = {2008}, doi = {10.1371/journal.pbio.0060257}, pmid = {18942891}, url = {https://doi.org/10.1371/journal.pbio.0060257} } @article{halawa2019-30704519, author = {Halawa, O. A. and Gatchel, JR. and Amariglio, R. E. and Rentz, D. M. and Sperling, R. A. and Johnson, K. A. and Marshall, G. A. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2019}, doi = {10.1186/s13195-019-0471-6}, pmid = {30704519}, url = {https://doi.org/10.1186/s13195-019-0471-6} } @article{baugh2012-22552850, author = {Baugh, C. M. and Stamm, J. M. and Riley, D. O. and Gavett, B. E. and Shenton, M. E. and Lin, A. and Nowinski, C. J. and Cantu, R. C. and others}, title = {{Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma}}, journal = {Brain imaging and behavior}, year = {2012}, doi = {10.1007/s11682-012-9164-5}, pmid = {22552850}, url = {https://doi.org/10.1007/s11682-012-9164-5} } @article{mendez2025-41518606, author = {Mendez, Brahyan J. Galindo and Teng, Ling and Marshall, Gad A. and Liu, Lei and Chhatwal, Jasmeer P. and Hohman, Timothy J. and Mayeux, Richard P and De Jager, Philip L. and others}, title = {{Microglia‐specific Alzheimer's disease polygenic risk score predicts longitudinal increase in plasma tau and faster cognitive decline in cognitively unimpaired older adults}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70856_106441}, pmid = {41518606}, url = {https://doi.org/10.1002/alz70856_106441} } @article{sperling2025-41450236, author = {Sperling, Reisa Anne and RAMAN, REMA}, title = {{How to efficiently move towards primary prevention in sporadic AD}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70859_105951}, pmid = {41450236}, url = {https://doi.org/10.1002/alz70859_105951} } @article{farrell2024-38988055, author = {Farrell, M. E. and Thibault, E. G. and Becker, J. A. and Price, J. C. and Healy, B. C. and Hanseeuw, B. J. and Buckley, R. F. and Jacobs, H. I. L. and others}, title = {{Spatial extent as a sensitive amyloid-PET metric in preclinical Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.14036}, pmid = {38988055}, url = {https://doi.org/10.1002/alz.14036} } @article{wells2019-31564434, author = {Wells, H. R. R. and Freidin, M. B. and Zainul Abidin, F. N. and Payton, A. and Dawes, P. and Munro, K. J. and Morton, C. C. and Moore, D. R. and others}, title = {{GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank}}, journal = {American journal of human genetics}, year = {2019}, doi = {10.1016/j.ajhg.2019.09.008}, pmid = {31564434}, url = {https://doi.org/10.1016/j.ajhg.2019.09.008} } @article{hinton2005-16078970, author = {Hinton, L. and Franz, C. E. and Yeo, G. and Levkoff, S. E.}, title = {{Conceptions of dementia in a multiethnic sample of family caregivers}}, journal = {Journal of the American Geriatrics Society}, year = {2005}, doi = {10.1111/j.1532-5415.2005.53409.x}, pmid = {16078970}, url = {https://doi.org/10.1111/j.1532-5415.2005.53409.x} } @article{pascual2026-41865347, author = {Pascual, JR. and Rivera, I. and Nguyen, H. and Ngo, P. T. and Hoang, A. and Andrews, E. J. and Rouanet, J. and Wright, S. T. and others}, title = {{Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan}}, journal = {Acta neuropathologica}, year = {2026}, doi = {10.1007/s00401-026-02994-8}, pmid = {41865347}, url = {https://doi.org/10.1007/s00401-026-02994-8} } @article{citron1996-8917563, author = {Citron, M. and Diehl, T. S. and Gordon, G. and Biere, A. L. and Seubert, P. and Selkoe, D. J.}, title = {{Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1996}, doi = {10.1073/pnas.93.23.13170}, pmid = {8917563}, url = {https://doi.org/10.1073/pnas.93.23.13170} } @article{xie2006-16645451, author = {Xie, Z. and Dong, Y. and Maeda, U. and Alfille, P. and Culley, D. J. and Crosby, G. and Tanzi, R. E.}, title = {{The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels}}, journal = {Anesthesiology}, year = {2006}, doi = {10.1097/00000542-200605000-00015}, pmid = {16645451}, url = {https://doi.org/10.1097/00000542-200605000-00015} } @article{xia1997-9223340, author = {Xia, W. and Zhang, J. and Perez, R. and Koo, E. H. and Selkoe, D. J.}, title = {{Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1997}, doi = {10.1073/pnas.94.15.8208}, pmid = {9223340}, url = {https://doi.org/10.1073/pnas.94.15.8208} } @article{hemming2007-17760499, author = {Hemming, M. L. and Patterson, M. and Reske-Nielsen, C. and Lin, L. and Isacson, O. and Selkoe, D. J.}, title = {{Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease}}, journal = {PLoS medicine}, year = {2007}, doi = {10.1371/journal.pmed.0040262}, pmid = {17760499}, url = {https://doi.org/10.1371/journal.pmed.0040262} } @article{crowley2011-21225347, author = {Crowley, K.}, title = {{Sleep and sleep disorders in older adults}}, journal = {Neuropsychology review}, year = {2011}, doi = {10.1007/s11065-010-9154-6}, pmid = {21225347}, url = {https://doi.org/10.1007/s11065-010-9154-6} } @article{frost2013-23747948, author = {Frost, J. L. and Le, K. X. and Cynis, H. and Ekpo, E. and Kleinschmidt, M. and Palmour, R. M. and Ervin, F. R. and Snigdha, S. and others}, title = {{Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models}}, journal = {The American journal of pathology}, year = {2013}, doi = {10.1016/j.ajpath.2013.05.005}, pmid = {23747948}, url = {https://doi.org/10.1016/j.ajpath.2013.05.005} } @article{wadsworth2012-22922821, author = {Wadsworth, L. P. and Lorius, N. and Donovan, N. J. and Locascio, J. J. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and Marshall, G. A.}, title = {{Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum}}, journal = {Dementia and geriatric cognitive disorders}, year = {2012}, doi = {10.1159/000342119}, pmid = {22922821}, url = {https://doi.org/10.1159/000342119} } @article{cho2010-20558735, author = {Cho, H. H. and Cahill, C. M. and Vanderburg, C. R. and Scherzer, C. R. and Wang, B. and Huang, X. and Rogers, J. T.}, title = {{Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1}}, journal = {The Journal of biological chemistry}, year = {2010}, doi = {10.1074/jbc.m110.149161}, pmid = {20558735}, url = {https://doi.org/10.1074/jbc.m110.149161} } @article{xu2014-24441878, author = {Xu, Z. and Dong, Y. and Wang, H. and Culley, D. J. and Marcantonio, E. R. and Crosby, G. and Tanzi, R. E. and Zhang, Y. and others}, title = {{Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice}}, journal = {Scientific reports}, year = {2014}, doi = {10.1038/srep03766}, pmid = {24441878}, url = {https://doi.org/10.1038/srep03766} } @article{terzioglu2023-38017562, author = {Terzioglu, G. and Young-Pearse, T. L.}, title = {{Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2023}, doi = {10.1186/s13024-023-00674-9}, pmid = {38017562}, url = {https://doi.org/10.1186/s13024-023-00674-9} } @article{miller2008-17846109, author = {Miller, S. L. and Fenstermacher, E. and Bates, J. and Blacker, D. and Sperling, R. A. and Dickerson, B. C.}, title = {{Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2008}, doi = {10.1136/jnnp.2007.124149}, pmid = {17846109}, url = {https://doi.org/10.1136/jnnp.2007.124149} } @article{altschuler2025-40797280, author = {Altschuler, Florencia and Canziani, Verónica and Fraile-Vazquez, Matias E and González-Gómez, Raúl and Hernández, Hernán Guillermo and Báez, Sandra and Migeot, Joaquín and Fittipaldi, Sol and others}, title = {{White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study}}, journal = {Alzheimer s Research \& Therapy}, year = {2025}, doi = {10.1186/s13195-025-01832-5}, pmid = {40797280}, url = {https://doi.org/10.1186/s13195-025-01832-5} } @article{mendez2026-41920173, author = {Mendez, Joel Sanchez and Queme, Bryan and Fu, Yubo and Morrison, John L. and Lewinger, Juan Pablo and Kawaguchi, Eric S. and Mi, Huaiyu and Obón‐Santacana, Mireia and others}, title = {{TGF-β Pathway–Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method}}, journal = {Cancer Epidemiology Biomarkers \& Prevention}, year = {2026}, doi = {10.1158/1055-9965.epi-25-1754}, pmid = {41920173}, url = {https://doi.org/10.1158/1055-9965.epi-25-1754} } @article{li2025-40218880, author = {Li, Mengyan and Ren, Ruodi and Wang, Kunkun and Wang, Shan and Chow, Andrew and Yang, Andrew and Lu, Yun and Leo, Christopher}, title = {{Effects of B Vitamins on Homocysteine Lowering and Thrombotic Risk Reduction—A Review of Randomized Controlled Trials Published Since January 1996}}, journal = {Nutrients}, year = {2025}, doi = {10.3390/nu17071122}, pmid = {40218880}, url = {https://doi.org/10.3390/nu17071122} } @article{howard2025-40737611, author = {Howard, Calvin and Johnson, Amy M and Baratono, Sheena R. and Faust, Katharina and Peedicail, Joseph Samuel and Ng, Marcus}, title = {{Machine Learning–Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial}}, journal = {Journal of Medical Internet Research}, year = {2025}, doi = {10.2196/67446}, pmid = {40737611}, url = {https://doi.org/10.2196/67446} } @article{dickerson2001-3378c42f, author = {Dickerson, Brad C. and Goncharova, Irina I. and Sullivan, Matt and Forchetti, Concetta and Wilson, Robert S. and Bennett, David Alan and Beckett, Laurel A. and deToledo‐Morrell, Leyla}, title = {{MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease}}, journal = {Neurobiology of Aging}, year = {2001}, doi = {10.1016/s0197-4580(01)00271-8}, url = {https://doi.org/10.1016/s0197-4580(01)00271-8} } @article{gholipour2017-28109983, author = {Gholipour, T. and Mitchell, S. and Sarkis, R. A. and Chemali, Z.}, title = {{The clinical and neurobehavioral course of Down syndrome and dementia with or without new-onset epilepsy}}, journal = {Epilepsy \& behavior : E\&B}, year = {2017}, doi = {10.1016/j.yebeh.2016.12.014}, pmid = {28109983}, url = {https://doi.org/10.1016/j.yebeh.2016.12.014} } @article{schnoder2016-26663083, author = {Schnöder, L. and Hao, W. and Qin, Y. and Liu, S. and Tomic, I. and Liu, X. and Fassbender, K. and Liu, Y.}, title = {{Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1}}, journal = {The Journal of biological chemistry}, year = {2016}, doi = {10.1074/jbc.m115.695916}, pmid = {26663083}, url = {https://doi.org/10.1074/jbc.m115.695916} } @article{thibault2026-41830758, author = {Thibault, Emma G. and Montenegro, Grace A Del Carmen and Becker, John Alex and Price, Julie C. and Healy, B.F and Hanseeuw, Bernard Jimmy and Buckley, Rachel F. and Jacobs, Heidi I.L. and others}, title = {{Amyloid spatial extent with florbetapir-PET for early detection of preclinical Alzheimer’s disease}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100529}, pmid = {41830758}, url = {https://doi.org/10.1016/j.tjpad.2026.100529} } @article{tack2025-40118792, author = {Tack, Reinier W. P. and Senff, Jasper Rudolf and Kimball, Tamara N. and Prapiadou, Savvina and Tan, Benjamin Yong‐Qiang and Yechoor, Nirupama and Rosand, Jonathan M. and Singh, Sanjula and others}, title = {{Reliability and Validity of Self‐Reported Risk Factors for Stroke and Dementia}}, journal = {Journal of the American Heart Association}, year = {2025}, doi = {10.1161/jaha.124.038730}, pmid = {40118792}, url = {https://doi.org/10.1161/jaha.124.038730} } @article{brandao2025-39813317, author = {Brandão, Wesley Nogueira and Jain, Nimansha and Yin, Zhuoran and Kleemann, Kilian L. and Carpenter, Madison and Bao, Xin and Serrano, Javier Remolina and Tycksen, Eric and others}, title = {{Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy}}, journal = {Science Translational Medicine}, year = {2025}, doi = {10.1126/scitranslmed.adk3690}, pmid = {39813317}, url = {https://doi.org/10.1126/scitranslmed.adk3690} } @article{hshieh2025-40380784, author = {Hshieh, Tammy T. and Chapin, Benjamin Albert and Mak, W and Xu, Guoquan and Schmitt, Eva M. and Marcantonio, Edward R. and Shanes, Hannah and Heine, Cole and others}, title = {{Better Assessment of Illness Study (BASIL) II for Delirium Severity: Study Design, Variables, and Methods}}, journal = {Journal of Geriatric Psychiatry and Neurology}, year = {2025}, doi = {10.1177/08919887251343604}, pmid = {40380784}, url = {https://doi.org/10.1177/08919887251343604} } @article{baril2022-34310026, author = {Baril, A. A. and Beiser, A. S. and Sanchez, E. and Mysliwiec, V. and Redline, S. and Gottlieb, D. J. and O'Connor, G. T. and Gonzales, M. M. and others}, title = {{Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2022}, doi = {10.1002/alz.12405}, pmid = {34310026}, url = {https://doi.org/10.1002/alz.12405} } @article{yiallourou2026-42525904, author = {Yiallourou, Stephanie R and Wiedner, Crystal and Yang, Qiong and Baril, Andrée‐Ann and Misialek, Jeffrey R. and Kline, Christopher E. and Harrison, Stephanie and Bernal, Rebecca and others}, title = {{Association of Sleep Variables With Cognitive Performance and the Risk of Dementia in the Sleep and Dementia Consortium}}, journal = {Neurology}, year = {2026}, doi = {10.1212/wnl.0000000000218182}, pmid = {42525904}, url = {https://doi.org/10.1212/wnl.0000000000218182} } @article{tremblay2025-40084663, author = {Tremblay, Cécilia and Shakir, Neha and Zhang, Nan and Adler, Charles H. and Shill, Holly A. and Mehta, Shyamal H. and Driver‐Dunckley, Erika D. and Belden, Christine M. and others}, title = {{Associations between neuropsychiatric symptoms and pathology in clinicopathologically defined Alzheimer's disease, Alzheimer's disease with Lewy bodies, and dementia with Lewy bodies}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251320670}, pmid = {40084663}, url = {https://doi.org/10.1177/13872877251320670} } @article{madigan2012-22877803, author = {Madigan, D. and Sigelman, D. W. and Mayer, J. W. and Furberg, C. D. and Avorn, J.}, title = {{Under-reporting of cardiovascular events in the rofecoxib Alzheimer disease studies}}, journal = {American heart journal}, year = {2012}, doi = {10.1016/j.ahj.2012.05.002}, pmid = {22877803}, url = {https://doi.org/10.1016/j.ahj.2012.05.002} } @article{wooten2017-27660144, author = {Wooten, D. W. and Guehl, N. J. and Verwer, E. E. and Shoup, T. M. and Yokell, D. L. and Zubcevik, N. and Vasdev, N. and Zafonte, R. D. and others}, title = {{Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects}}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year = {2017}, doi = {10.2967/jnumed.115.170910}, pmid = {27660144}, url = {https://doi.org/10.2967/jnumed.115.170910} } @article{cash2025-40118731, author = {Cash, D. M. and Morgan, K. E. and O'Connor, A. and Veale, T. D. and Malone, I. B. and Poole, T. and Benzinger, T. L. and Gordon, B. A. and others}, title = {{Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100133}, pmid = {40118731}, url = {https://doi.org/10.1016/j.tjpad.2025.100133} } @article{torre2025-39863251, author = {Torre, Matthew and Zanella, Camila A. and Feany, Mel Β.}, title = {{The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and Alzheimer Disease}}, journal = {American Journal Of Pathology}, year = {2025}, doi = {10.1016/j.ajpath.2024.12.013}, pmid = {39863251}, url = {https://doi.org/10.1016/j.ajpath.2024.12.013} } @article{liu2026-41880148, author = {Liu, Yuxi and Li, Yanping and Li, Yuhan and Zhang, Yu Shrike and Wang, Yunhe and Gu, Xiao and Yue, Yiyang and Kang, Jae H and others}, title = {{Long‐term adherence and changes in the Mediterranean and MIND diets in relation to dementia risk and cognitive function}}, journal = {Alzheimer s \& Dementia}, year = {2026}, doi = {10.1002/alz.71324}, pmid = {41880148}, url = {https://doi.org/10.1002/alz.71324} } @article{porteny2025-40205431, author = {Porteny, Thalia and Lynch, Mary and Covaleski, Audrey and Tjia, Jennifer and GAZARIAN, PRISCILLA KEDDY and Reich, Amanda Jane and Perez, Stephen M. and Kennefick, Kristen and others}, title = {{Medical decision-making experiences of persons with dementia and their carepartners: a qualitative study}}, journal = {BMC Palliative Care}, year = {2025}, doi = {10.1186/s12904-025-01710-9}, pmid = {40205431}, url = {https://doi.org/10.1186/s12904-025-01710-9} } @article{daneshvar2011-22050943, author = {Daneshvar, D. H. and Riley, D. O. and Nowinski, C. J. and McKee, A. C. and Stern, R. A. and Cantu, R. C.}, title = {{Long-term consequences: effects on normal development profile after concussion}}, journal = {Physical medicine and rehabilitation clinics of North America}, year = {2011}, doi = {10.1016/j.pmr.2011.08.009}, pmid = {22050943}, url = {https://doi.org/10.1016/j.pmr.2011.08.009} } @article{moro2012-23143229, author = {Moro, M. L. and Giaccone, G. and Lombardi, R. and Indaco, A. and Uggetti, A. and Morbin, M. and Saccucci, S. and Di Fede, G. and others}, title = {{APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38}}, journal = {Acta neuropathologica}, year = {2012}, doi = {10.1007/s00401-012-1061-x}, pmid = {23143229}, url = {https://doi.org/10.1007/s00401-012-1061-x} } @article{marshall2014-24685624, author = {Marshall, G. A. and Lorius, N. and Locascio, J. J. and Hyman, B. T. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A.}, title = {{Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2014}, doi = {10.3233/jad-132768}, pmid = {24685624}, url = {https://doi.org/10.3233/jad-132768} } @article{hyle2026-42412430, author = {Hyle, Emily Parker and Ang, Luke and Luu, Grace and Kasaie, Parastu and Dai, Dannie and Ebem, Florence and Phelan, Jessica and Koiso, Satoshi and others}, title = {{Ten-Year Cost Projections for Medicare Beneficiaries 65 Years or Older With HIV}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.21966}, pmid = {42412430}, url = {https://doi.org/10.1001/jamanetworkopen.2026.21966} } @article{singhal2025-40359013, author = {Singhal, Tarun and Cicero, Steven and Gale, Seth A. and Horan, Nicolas and Dubey, Shipra and Marshall, Gad A. and Weiner, Howard L.}, title = {{Dampening of Microglial Activation With Nasal Foralumab Administration in Moderate Alzheimer’s Disease Dementia}}, journal = {Clinical Nuclear Medicine}, year = {2025}, doi = {10.1097/rlu.0000000000005955}, pmid = {40359013}, url = {https://doi.org/10.1097/rlu.0000000000005955} } @article{lee2025-40042467, author = {Lee, Haeok and Mlombe, Yohannie B. and Song, Yeunjoo E. and Yang, Hyun‐Sik and Phiri, Tiwonge Elisa and Maseke, Joseph and Bauleni, Esther M. and Jun, Gyungah and others}, title = {{Dementia prevalence and risk factors in people with and without HIV in Malawi: A medical record review}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70009}, pmid = {40042467}, url = {https://doi.org/10.1002/alz.70009} } @article{fisette2012-22303960, author = {Fisette, J. F. and Montagna, D. R. and Mihailescu, M. R. and Wolfe, M. S.}, title = {{A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing}}, journal = {Journal of neurochemistry}, year = {2012}, doi = {10.1111/j.1471-4159.2012.07680.x}, pmid = {22303960}, url = {https://doi.org/10.1111/j.1471-4159.2012.07680.x} } @article{kim2026-42234953, author = {Kim, Daeeun and McInerney, Katelyn and Dagli, Chaitali S. and Armstrong, Nicole D. and Cushman, Mary and Bennett, Aleena and Blue, Elizabeth E. and Sofer, Tamar and others}, title = {{Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population}}, journal = {Neurology}, year = {2026}, doi = {10.1212/wnl.0000000000218163}, pmid = {42234953}, url = {https://doi.org/10.1212/wnl.0000000000218163} } @article{howard2025-40536945, author = {Howard, Calvin and Johnson, Amy M and Peedicail, Joseph Samuel and Ng, Marcus}, title = {{The Rapid Online Cognitive Assessment for the Detection of Neurocognitive Disorder: Open-Label Study}}, journal = {Journal of Medical Internet Research}, year = {2025}, doi = {10.2196/66735}, pmid = {40536945}, url = {https://doi.org/10.2196/66735} } @article{han2025-40239644, author = {Han, Xudong and Zhang, Yichi and Petrosky, Jillian N and Bald, Sarah and Sherva, Richard and Labadorf, Adam Thomas and Cherry, Jonathan D. and Chung, Jaeyoon and others}, title = {{A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes}}, journal = {Cell Reports Medicine}, year = {2025}, doi = {10.1016/j.xcrm.2025.102084}, pmid = {40239644}, url = {https://doi.org/10.1016/j.xcrm.2025.102084} } @article{polinski2007-17485754, author = {Polinski, Jennifer M. and Wang, Philip S. and Fischer, Michael A.}, title = {{Medicaid’s Prior Authorization Program And Access To Atypical Antipsychotic Medications}}, journal = {Health Affairs}, year = {2007}, doi = {10.1377/hlthaff.26.3.750}, pmid = {17485754}, url = {https://doi.org/10.1377/hlthaff.26.3.750} } @article{kurniansyah2025-41434242, author = {Kurniansyah, Nuzulul and Tasaki, Shinya and Zhu, Congcong and Farrell, John Joseph and Rehman, Habbiburr and Sherva, Richard and Hauger, Richard L. and Merritt, Victoria C. and others}, title = {{Hormone replacement therapy in women and vascular risk factors modify the association of a multi‐ancestry polygenic risk score with Alzheimer disease and related traits}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70861_108536}, pmid = {41434242}, url = {https://doi.org/10.1002/alz70861_108536} } @article{skotko2023-36437642, author = {Skotko, B. G. and Krell, K. and Haugen, K. and Torres, A. and Nieves, A. and Dhand, A.}, title = {{Personal social networks of people with Down syndrome}}, journal = {American journal of medical genetics. Part A}, year = {2023}, doi = {10.1002/ajmg.a.63059}, pmid = {36437642}, url = {https://doi.org/10.1002/ajmg.a.63059} } @article{stern2025-41435407, author = {Stern, Andrew M. and Francis, Anna G. and Meunier, Angela L. and Anderson, Amirah K. and Hennessey, Elizabeth L. and Miller, Michael B. and Lemere, Cynthia Ann and Selkoe, Dennis J.}, title = {{Lecanemab, aducanumab, and donanemab bind the same human Alzheimer disease Aβ aggregates at different epitopes}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_099914}, pmid = {41435407}, url = {https://doi.org/10.1002/alz70855_099914} } @article{naci2023-9bc9eb86, author = {Naci, Huseyin and Forrest, Robin and Zhai, Mike and Stofesky, Amanda R. and Kesselheim, Aaron S.}, title = {{Characteristics of Prior Authorization Policies for New Drugs in Medicare Part D}}, journal = {JAMA Health Forum}, year = {2023}, doi = {10.1001/jamahealthforum.2022.5610}, url = {https://doi.org/10.1001/jamahealthforum.2022.5610} } @article{dickerson2001-11705634, author = {Dickerson, B. C. and Goncharova, I. and Sullivan, M. P. and Forchetti, C. and Wilson, R. S. and Bennett, D. A. and Beckett, L. A. and deToledo-Morrell, L.}, title = {{MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease}}, journal = {Neurobiology of aging}, year = {2001}, doi = {10.1016/s0197-4580(01)00271-8}, pmid = {11705634}, url = {https://doi.org/10.1016/s0197-4580(01)00271-8} } @article{lemere2025-41434072, author = {Lemere, Cynthia Ann}, title = {{Mouse models for studying anti‐amyloid antibody‐induced ARIA}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70861_108865}, pmid = {41434072}, url = {https://doi.org/10.1002/alz70861_108865} } @article{riera2025-d5d70de7, author = {Riera, Kayla and Gale, Seth A. and Ghorayeb, Georges and McFeeley, Brittany M. and Daffner, Kirk R.}, title = {{Degree of Adherence to Brain Health Recommendations in Patients Pursuing Anti-Amyloid Antibody Therapy for Alzheimer’s Disease (S23.003)}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000210695}, url = {https://doi.org/10.1212/wnl.0000000000210695} } @article{caro2026-dd11f0ff, author = {Caro, Ilana and Sargurupremraj, Muralidharan and Yang, Chengran and Akinleye, Callistus A. and Trégouët, David‐Alexandre and Akinyemi, Rufus and Shigemizu, Daichi and Coker, Motunrayo Mojoyin and others}, title = {{Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries}}, journal = {Neurology Genetics}, year = {2026}, doi = {10.1212/nxg.0000000000200425}, url = {https://doi.org/10.1212/nxg.0000000000200425} } @article{heide2017-28318110, author = {Heide, Loehlein Fier and Dmitry, Prokopenko and Julian, Hecker and Cho Michael, H. and Silverman Edwin, K. and Weiss Scott, T. and Tanzi Rudolph, E. and Christoph, Lange}, title = {{On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows}}, journal = {Genetic epidemiology}, year = {2017}, doi = {10.1002/gepi.22040}, pmid = {28318110}, url = {https://doi.org/10.1002/gepi.22040} } @article{gujjala2024-77053260, author = {Gujjala, V. A. and Klimek, I. and Abyadeh, M. and Tyshkovskiy, A. and Oz, N. and Castro, J. P. and Gladyshev, V. N. and Newton, J. and others}, title = {{A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer’s disease and aging research}}, journal = {bioRxiv}, year = {2024}, doi = {10.1101/2024.04.19.590328}, url = {https://doi.org/10.1101/2024.04.19.590328} } @article{lin2026-2a0fe361, author = {Lin, W. and Beric, A. and Wisch, J. K. and Baker, B. and Jerome, G. and Minton, M. and Preminger, S. and Stauber, J. and others}, title = {{Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer’s Disease}}, journal = {medRxiv}, year = {2026}, doi = {10.64898/2026.03.31.26349851}, url = {https://doi.org/10.64898/2026.03.31.26349851} } @article{butler2025-35ab99e8, author = {Butler, P. M. and Francis, A. and Meunier, A. L. and Anderson, A. K. and Hennessey, E. L. and Miller, M. B. and Lemere, C. A. and Selkoe, D. J. and others}, title = {{Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain}}, journal = {bioRxiv}, year = {2025}, doi = {10.1101/2025.05.20.654902}, url = {https://doi.org/10.1101/2025.05.20.654902} }