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% Source: https://alzhub.org/research?category=prevention_trials&design=rct
% 79 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{brodaty2025-39875685,
  author  = {Brodaty, Henry and Chau, Tiffany and Heffernan, Megan and Ginige, Jeewani A and Andrews, Gavin and Millard, Michael and Sachdev, Perminder S and Anstey, Kaarin J and others},
  title   = {{An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: a randomized controlled trial}},
  journal = {Nature medicine},
  year    = {2025},
  doi     = {10.1038/s41591-024-03351-6},
  pmid    = {39875685},
  url     = {https://doi.org/10.1038/s41591-024-03351-6}
}

@article{edwards2017-29201994,
  author  = {Edwards, J. D. and Xu, H. and Clark, D. O. and Guey, L. T. and Ross, L. A. and Unverzagt, F. W.},
  title   = {{Speed of processing training results in lower risk of dementia}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2017},
  doi     = {10.1016/j.trci.2017.09.002},
  pmid    = {29201994},
  url     = {https://doi.org/10.1016/j.trci.2017.09.002}
}

@article{oki2024-39229900,
  author  = {Oki, Y. and Osaki, T. and Kumagai, R. and Murata, S. and Encho, H. and Ono, R. and Yasuda, H. and Kowa, H.},
  title   = {{An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14170},
  pmid    = {39229900},
  url     = {https://doi.org/10.1002/alz.14170}
}

@article{kim2026-42475653,
  author  = {Kim, Da Ae and Lee, Sun Min and Sun, Kyunghwa and Park, Ji Hyun and Park, Yoo Kyoung and Jeong, Jee Hyang and Hong, Chang Hyung and Jung, Jiwoo and others},
  title   = {{Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000218297},
  pmid    = {42475653},
  url     = {https://doi.org/10.1212/wnl.0000000000218297}
}

@article{simone2024-37930366,
  author  = {Simone, Tamar and Peltz, Carrie and Rosenberg, Dori E and Barnes, Deborah E and Fleckenstein, Lynn E and Dublin, Sascha and Yaffe, Kristine},
  title   = {{The Impact of Pandemic-Related Restrictions on Dementia Risk Factors in Older Adults}},
  journal = {Journal of applied gerontology : the official journal of the Southern Gerontological Society},
  year    = {2024},
  doi     = {10.1177/07334648231210671},
  pmid    = {37930366},
  url     = {https://doi.org/10.1177/07334648231210671}
}

@article{moon2021-34148030,
  author  = {Moon, S. Y. and Hong, C. H. and Jeong, J. H. and Park, Y. K. and Na, H. R. and Song, H. S. and Kim, B. C. and Park, K. W. and others},
  title   = {{Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial}},
  journal = {Aging},
  year    = {2021},
  doi     = {10.18632/aging.203213},
  pmid    = {34148030},
  url     = {https://doi.org/10.18632/aging.203213}
}

@article{thunborg2024-38812047,
  author  = {Thunborg, C. and Wang, R. and Rosenberg, A. and Sindi, S. and Andersen, P. and Andrieu, S. and Broersen, L. M. and Coley, N. and others},
  title   = {{Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer's disease: the MIND-ADmini randomized controlled trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01468-x},
  pmid    = {38812047},
  url     = {https://doi.org/10.1186/s13195-024-01468-x}
}

@article{zulke2024-37768074,
  author  = {Zülke, A. E. and Pabst, A. and Luppa, M. and Roehr, S. and Seidling, H. and Oey, A. and Cardona, M. I. and Blotenberg, I. and others},
  title   = {{A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13486},
  pmid    = {37768074},
  url     = {https://doi.org/10.1002/alz.13486}
}

@article{doniger2018-29955655,
  author  = {Doniger, G. M. and Beeri, M. S. and Bahar-Fuchs, A. and Gottlieb, A. and Tkachov, A. and Kenan, H. and Livny, A. and Bahat, Y. and others},
  title   = {{Virtual reality-based cognitive-motor training for middle-aged adults at high Alzheimer's disease risk: A randomized controlled trial}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2018},
  doi     = {10.1016/j.trci.2018.02.005},
  pmid    = {29955655},
  url     = {https://doi.org/10.1016/j.trci.2018.02.005}
}

@article{desoutobarreto2021-33569560,
  author  = {de Souto Barreto, P. and Pothier, K. and Soriano, G. and Lussier, M. and Bherer, L. and Guyonnet, S. and Piau, A. and Ousset, P. J. and others},
  title   = {{A Web-Based Multidomain Lifestyle Intervention for Older Adults: The eMIND Randomized Controlled Trial}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2021},
  doi     = {10.14283/jpad.2020.70},
  pmid    = {33569560},
  url     = {https://doi.org/10.14283/jpad.2020.70}
}

@article{xu2022-35098972,
  author  = {Xu, X. and Chew, K. A. and Wong, Z. X. and Phua, A. K. S. and Chong, E. J. Y. and Teo, C. K. L. and Sathe, N. and Chooi, Y. C. and others},
  title   = {{The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2022},
  doi     = {10.14283/jpad.2022.5},
  pmid    = {35098972},
  url     = {https://doi.org/10.14283/jpad.2022.5}
}

@article{ngandu2022-34668644,
  author  = {Ngandu, T. and Lehtisalo, J. and Korkki, S. and Solomon, A. and Coley, N. and Antikainen, R. and Bäckman, L. and Hänninen, T. and others},
  title   = {{The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12492},
  pmid    = {34668644},
  url     = {https://doi.org/10.1002/alz.12492}
}

@article{kwan2024-39259959,
  author  = {Kwan, R. Y. C. and Liu, J. and Sin, O. S. K. and Fong, K. N. K. and Qin, J. and Wong, J. C. Y. and Lai, C.},
  title   = {{Effects of Virtual Reality Motor-Cognitive Training for Older People With Cognitive Frailty: Multicentered Randomized Controlled Trial}},
  journal = {Journal of medical Internet research},
  year    = {2024},
  doi     = {10.2196/57809},
  pmid    = {39259959},
  url     = {https://doi.org/10.2196/57809}
}

@article{lorenzon2025-40998691,
  author  = {Lorenzon, Giulia and Marseglia, Anna and Mohanty, Rosaleena and Lehtisalo, Jenni and Poulakis, Konstantinos and Ngandu, Tiia and Solomon, Alina and Kivipelto, Miia and others},
  title   = {{Brain patterns and risk factors in the FINGER RCT multimodal lifestyle intervention}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100390},
  pmid    = {40998691},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100390}
}

@article{li2024-38706275,
  author  = {Li, S-Y and Xie, X-Y and Liu, D and Cheng, G-R and Hu, F-F and Zeng, D-Y and Chen, X-C and Jia, L-F and others},
  title   = {{China Initiative for Multi-Domain Intervention (CHINA-IN-MUDI) to Prevent Cognitive Decline: Study Design and Progress}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2024},
  doi     = {10.14283/jpad.2024.63},
  pmid    = {38706275},
  url     = {https://doi.org/10.14283/jpad.2024.63}
}

@article{liang2021-33765656,
  author  = {Liang, C. K. and Lee, W. J. and Hwang, A. C. and Lin, C. S. and Chou, M. Y. and Peng, L. N. and Lin, M. H. and Chen, L. K.},
  title   = {{Efficacy of Multidomain Intervention Against Physio-cognitive Decline Syndrome: A Cluster-randomized Trial}},
  journal = {Archives of gerontology and geriatrics},
  year    = {2021},
  doi     = {10.1016/j.archger.2021.104392},
  pmid    = {33765656},
  url     = {https://doi.org/10.1016/j.archger.2021.104392}
}

@article{ponvel2021-34092633,
  author  = {Ponvel, P. and Shahar, S. and Singh, D. K. A. and Ludin, A. F. M. and Rajikan, R. and Rajab, N. F. and Ai-Vyrn, C. and Din, N. C. and others},
  title   = {{Multidomain Intervention for Reversal of Cognitive Frailty, Towards a Personalized Approach (AGELESS Trial): Study Design}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-201607},
  pmid    = {34092633},
  url     = {https://doi.org/10.3233/jad-201607}
}

@article{salisbury2022-34492709,
  author  = {Salisbury, Dereck and Mathiason, Michelle A and Yu, Fang},
  title   = {{Exercise Dose and Aerobic Fitness Response in Alzheimer's Dementia: Findings from the FIT-AD Trial}},
  journal = {International journal of sports medicine},
  year    = {2022},
  doi     = {10.1055/a-1639-2307},
  pmid    = {34492709},
  url     = {https://doi.org/10.1055/a-1639-2307}
}

@article{law2019-31801630,
  author  = {Law, L. L. F. and Mok, V. C. T. and Yau, M. M. K.},
  title   = {{Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0548-2},
  pmid    = {31801630},
  url     = {https://doi.org/10.1186/s13195-019-0548-2}
}

@article{kulmala2021-34448856,
  author  = {Kulmala, J. and Rosenberg, A. and Ngandu, T. and Hemiö, K. and Tenkula, T. and Hyytiä, A. and Vienola, M. and Huhtamäki-Kuoppala, M. and others},
  title   = {{Facilitators and barriers to implementing lifestyle intervention programme to prevent cognitive decline}},
  journal = {European journal of public health},
  year    = {2021},
  doi     = {10.1093/eurpub/ckab087},
  pmid    = {34448856},
  url     = {https://doi.org/10.1093/eurpub/ckab087}
}

@article{park2021-34360490,
  author  = {Park, E. A. and Jung, A. R. and Lee, K. A.},
  title   = {{The Humanoid Robot Sil-Bot in a Cognitive Training Program for Community-Dwelling Elderly People with Mild Cognitive Impairment during the COVID-19 Pandemic: A Randomized Controlled Trial}},
  journal = {International journal of environmental research and public health},
  year    = {2021},
  doi     = {10.3390/ijerph18158198},
  pmid    = {34360490},
  url     = {https://doi.org/10.3390/ijerph18158198}
}

@article{park2020-32319247,
  author  = {Park, H. K. and Jeong, J. H. and Moon, S. Y. and Park, Y. K. and Hong, C. H. and Na, H. R. and Song, H. S. and Lee, S. M. and others},
  title   = {{South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial}},
  journal = {Journal of clinical neurology (Seoul, Korea)},
  year    = {2020},
  doi     = {10.3988/jcn.2020.16.2.292},
  pmid    = {32319247},
  url     = {https://doi.org/10.3988/jcn.2020.16.2.292}
}

@article{bell2022-35901382,
  author  = {Bell, T. R. and Sprague, B. N. and Ross, L. A.},
  title   = {{Longitudinal associations of pain and cognitive decline in community-dwelling older adults}},
  journal = {Psychology and aging},
  year    = {2022},
  doi     = {10.1037/pag0000699},
  pmid    = {35901382},
  url     = {https://doi.org/10.1037/pag0000699}
}

@article{tussinghumphreys2017-28600159,
  author  = {Tussing-Humphreys, L. and Lamar, M. and Blumenthal, J. A. and Babyak, M. and Fantuzzi, G. and Blumstein, L. and Schiffer, L. and Fitzgibbon, M. L.},
  title   = {{Building research in diet and cognition: The BRIDGE randomized controlled trial}},
  journal = {Contemporary clinical trials},
  year    = {2017},
  doi     = {10.1016/j.cct.2017.06.003},
  pmid    = {28600159},
  url     = {https://doi.org/10.1016/j.cct.2017.06.003}
}

@article{solomon2021-34151805,
  author  = {Solomon, Alina and Handels, Ron and Wimo, Anders and Antikainen, Riitta and Laatikainen, Tiina and Levälahti, Esko and Peltonen, Markku and Soininen, Hilkka and others},
  title   = {{Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210331},
  pmid    = {34151805},
  url     = {https://doi.org/10.3233/jad-210331}
}

@article{stephen2019-31164160,
  author  = {Stephen, R. and Liu, Y. and Ngandu, T. and Antikainen, R. and Hulkkonen, J. and Koikkalainen, J. and Kemppainen, N. and Lötjönen, J. and others},
  title   = {{Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)}},
  journal = {Alzheimer's research \& therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0506-z},
  pmid    = {31164160},
  url     = {https://doi.org/10.1186/s13195-019-0506-z}
}

@article{inskip2016-27258533,
  author  = {Inskip, Michael and Mavros, Yorgi and Sachdev, Perminder S and Singh, Maria A Fiatarone},
  title   = {{Exercise for Individuals with Lewy Body Dementia: A Systematic Review}},
  journal = {PloS one},
  year    = {2016},
  doi     = {10.1371/journal.pone.0156520},
  pmid    = {27258533},
  url     = {https://doi.org/10.1371/journal.pone.0156520}
}

@article{liu2021-33434704,
  author  = {Liu, X. and Morris, M. C. and Dhana, K. and Ventrelle, J. and Johnson, K. and Bishop, L. and Hollings, C. S. and Boulin, A. and others},
  title   = {{Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline}},
  journal = {Contemporary clinical trials},
  year    = {2021},
  doi     = {10.1016/j.cct.2021.106270},
  pmid    = {33434704},
  url     = {https://doi.org/10.1016/j.cct.2021.106270}
}

@article{kulmala2019-30809801,
  author  = {Kulmala, J. and Ngandu, T. and Havulinna, S. and Levälahti, E. and Lehtisalo, J. and Solomon, A. and Antikainen, R. and Laatikainen, T. and others},
  title   = {{The Effect of Multidomain Lifestyle Intervention on Daily Functioning in Older People}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2019},
  doi     = {10.1111/jgs.15837},
  pmid    = {30809801},
  url     = {https://doi.org/10.1111/jgs.15837}
}

@article{bernini2021-32895890,
  author  = {Bernini, S. and Panzarasa, S. and Barbieri, M. and Sinforiani, E. and Quaglini, S. and Tassorelli, C. and Bottiroli, S.},
  title   = {{A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool}},
  journal = {Aging clinical and experimental research},
  year    = {2021},
  doi     = {10.1007/s40520-020-01665-2},
  pmid    = {32895890},
  url     = {https://doi.org/10.1007/s40520-020-01665-2}
}

@article{rodella2022-34156651,
  author  = {Rodella, C. and Bernini, S. and Panzarasa, S. and Sinforiani, E. and Picascia, M. and Quaglini, S. and Cavallini, E. and Vecchi, T. and others},
  title   = {{A double-blind randomized controlled trial combining cognitive training (CoRe) and neurostimulation (tDCS) in the early stages of cognitive impairment}},
  journal = {Aging clinical and experimental research},
  year    = {2022},
  doi     = {10.1007/s40520-021-01912-0},
  pmid    = {34156651},
  url     = {https://doi.org/10.1007/s40520-021-01912-0}
}

@article{stephen2020-32925045,
  author  = {Stephen, R. and Solomon, A. and Ngandu, T. and Levälahti, E. and Rinne, J. O. and Kemppainen, N. and Parkkola, R. and Antikainen, R. and others},
  title   = {{White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200423},
  pmid    = {32925045},
  url     = {https://doi.org/10.3233/jad-200423}
}

@article{kallio2018-29345724,
  author  = {Kallio, E. L. and Öhman, H. and Hietanen, M. and Soini, H. and Strandberg, T. E. and Kautiainen, H. and Pitkälä, K. H.},
  title   = {{Effects of Cognitive Training on Cognition and Quality of Life of Older Persons with Dementia}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2018},
  doi     = {10.1111/jgs.15196},
  pmid    = {29345724},
  url     = {https://doi.org/10.1111/jgs.15196}
}

@article{beishuizen2017-28263374,
  author  = {Beishuizen, C. R. L. and Coley, N. and Moll van Charante, E. P. and van Gool, W. A. and Richard, E. and Andrieu, S.},
  title   = {{Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2017},
  doi     = {10.1111/jgs.14834},
  pmid    = {28263374},
  url     = {https://doi.org/10.1111/jgs.14834}
}

@article{tomoto2022-34570024,
  author  = {Tomoto, Tsubasa and Le, Tran and Tarumi, Takashi and Dieppa, Marisara and Bell, Kathleen and Madden, Christopher and Zhang, Rong and Ding, Kan},
  title   = {{Carotid Arterial Compliance and Aerobic Exercise Training in Chronic Traumatic Brain Injury: A Pilot Study}},
  journal = {The Journal of head trauma rehabilitation},
  year    = {2022},
  doi     = {10.1097/htr.0000000000000722},
  pmid    = {34570024},
  url     = {https://doi.org/10.1097/htr.0000000000000722}
}

@article{mcmaster2020-32909259,
  author  = {McMaster, M. and Kim, S. and Clare, L. and Torres, S. J. and Cherbuin, N. and DʼEste, C. and Anstey, K. J.},
  title   = {{Lifestyle Risk Factors and Cognitive Outcomes from the Multidomain Dementia Risk Reduction Randomized Controlled Trial, Body Brain Life for Cognitive Decline (BBL-CD)}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2020},
  doi     = {10.1111/jgs.16762},
  pmid    = {32909259},
  url     = {https://doi.org/10.1111/jgs.16762}
}

@article{tenbrinke2018-29378515,
  author  = {Ten Brinke, L. F. and Best, JR. and Crockett, R. A. and Liu-Ambrose, T.},
  title   = {{The effects of an 8-week computerized cognitive training program in older adults: a study protocol for a randomized controlled trial}},
  journal = {BMC geriatrics},
  year    = {2018},
  doi     = {10.1186/s12877-018-0730-6},
  pmid    = {29378515},
  url     = {https://doi.org/10.1186/s12877-018-0730-6}
}

@article{xu2020-33194354,
  author  = {Xu, Z. and Zhang, D. and Lee, A. T. C. and Sit, R. W. S. and Wong, C. and Lee, E. K. P. and Yip, B. H. K. and Tiu, J. Y. S. and others},
  title   = {{A pilot feasibility randomized controlled trial on combining mind-body physical exercise, cognitive training, and nurse-led risk factor modification to reduce cognitive decline among older adults with mild cognitive impairment in primary care}},
  journal = {PeerJ},
  year    = {2020},
  doi     = {10.7717/peerj.9845},
  pmid    = {33194354},
  url     = {https://doi.org/10.7717/peerj.9845}
}

@article{coe2026-41669119,
  author  = {Coe, Norma B. and Miller, Katherine E. M. and Sun, Chuxuan and Taggert, Elizabeth and Gross, Alden L. and Jones, Richard Norman and Felix, Cynthia and Albert, Marilyn S. and others},
  title   = {{Impact of cognitive training on claims‐based diagnosed dementia over 20 years: evidence from the ACTIVE study}},
  journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
  year    = {2026},
  doi     = {10.1002/trc2.70197},
  pmid    = {41669119},
  url     = {https://doi.org/10.1002/trc2.70197}
}

@article{martinezlapiscina2014-24643340,
  author  = {Martínez-Lapiscina, E. H. and Galbete, C. and Corella, D. and Toledo, E. and Buil-Cosiales, P. and Salas-Salvado, J. and Ros, E. and Martinez-Gonzalez, M. A.},
  title   = {{Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial}},
  journal = {Genes \& nutrition},
  year    = {2014},
  doi     = {10.1007/s12263-014-0393-7},
  pmid    = {24643340},
  url     = {https://doi.org/10.1007/s12263-014-0393-7}
}

@article{petrelli2015-25534579,
  author  = {Petrelli, A. and Kaesberg, S. and Barbe, M. T. and Timmermann, L. and Rosen, J. B. and Fink, G. R. and Kessler, J. and Kalbe, E.},
  title   = {{Cognitive training in Parkinson's disease reduces cognitive decline in the long term}},
  journal = {European journal of neurology},
  year    = {2015},
  doi     = {10.1111/ene.12621},
  pmid    = {25534579},
  url     = {https://doi.org/10.1111/ene.12621}
}

@article{yeh2019-30639273,
  author  = {Yeh, T. T. and Chang, K. C. and Wu, C. Y.},
  title   = {{The Active Ingredient of Cognitive Restoration: A Multicenter Randomized Controlled Trial of Sequential Combination of Aerobic Exercise and Computer-Based Cognitive Training in Stroke Survivors With Cognitive Decline}},
  journal = {Archives of physical medicine and rehabilitation},
  year    = {2019},
  doi     = {10.1016/j.apmr.2018.12.020},
  pmid    = {30639273},
  url     = {https://doi.org/10.1016/j.apmr.2018.12.020}
}

@article{gill2016-26285025,
  author  = {Gill, D. P. and Gregory, M. A. and Zou, G. and Liu-Ambrose, T. and Shigematsu, R. and Hachinski, V. and Fitzgerald, C. and Petrella, R. J.},
  title   = {{The Healthy Mind, Healthy Mobility Trial: A Novel Exercise Program for Older Adults}},
  journal = {Medicine and science in sports and exercise},
  year    = {2016},
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  pmid    = {26285025},
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}

@article{bergamaschi2013-23784727,
  author  = {Bergamaschi, S. and Arcara, G. and Calza, A. and Villani, D. and Orgeta, V. and Mondini, S.},
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}

@article{hoffmann2016-26682695,
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  title   = {{Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial}},
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  year    = {2016},
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}

@article{smithray2014-25274713,
  author  = {Smith-Ray, R. L. and Makowski-Woidan, B. and Hughes, S. L.},
  title   = {{A randomized trial to measure the impact of a community-based cognitive training intervention on balance and gait in cognitively intact Black older adults}},
  journal = {Health education \& behavior : the official publication of the Society for Public Health Education},
  year    = {2014},
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@article{hassandra2021-33759797,
  author  = {Hassandra, M. and Galanis, E. and Hatzigeorgiadis, A. and Goudas, M. and Mouzakidis, C. and Karathanasi, E. M. and Petridou, N. and Tsolaki, M. and others},
  title   = {{Α Virtual Reality App for Physical and Cognitive Training of Older People With Mild Cognitive Impairment: Mixed Methods Feasibility Study}},
  journal = {JMIR serious games},
  year    = {2021},
  doi     = {10.2196/24170},
  pmid    = {33759797},
  url     = {https://doi.org/10.2196/24170}
}

@article{sugimoto2021-34585222,
  author  = {Sugimoto, T. and Sakurai, T. and Akatsu, H. and Doi, T. and Fujiwara, Y. and Hirakawa, A. and Kinoshita, F. and Kuzuya, M. and others},
  title   = {{The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2021},
  doi     = {10.14283/jpad.2021.29},
  pmid    = {34585222},
  url     = {https://doi.org/10.14283/jpad.2021.29}
}

@article{barbera2018-29480185,
  author  = {Barbera, M. and Mangialasche, F. and Jongstra, S. and Guillemont, J. and Ngandu, T. and Beishuizen, C. and Coley, N. and Brayne, C. and others},
  title   = {{Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults: The HATICE Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-170858},
  pmid    = {29480185},
  url     = {https://doi.org/10.3233/jad-170858}
}

@article{mcadamsdemarco2018-29340317,
  author  = {McAdams-DeMarco, M. A. and Konel, J. and Warsame, F. and Ying, H. and González Fernández, M. and Carlson, M. C. and Fine, D. M. and Appel, L. J. and others},
  title   = {{Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function}},
  journal = {Kidney international reports},
  year    = {2018},
  doi     = {10.1016/j.ekir.2017.08.006},
  pmid    = {29340317},
  url     = {https://doi.org/10.1016/j.ekir.2017.08.006}
}

@article{buitenweg2017-29209183,
  author  = {Buitenweg, J. I. V. and van de Ven, R. M. and Prinssen, S. and Murre, J. M. J. and Ridderinkhof, K. R.},
  title   = {{Cognitive Flexibility Training: A Large-Scale Multimodal Adaptive Active-Control Intervention Study in Healthy Older Adults}},
  journal = {Frontiers in human neuroscience},
  year    = {2017},
  doi     = {10.3389/fnhum.2017.00529},
  pmid    = {29209183},
  url     = {https://doi.org/10.3389/fnhum.2017.00529}
}

@article{murukesu2020-33014971,
  author  = {Murukesu, R. R. and Singh, D. K. A. and Shahar, S. and Subramaniam, P.},
  title   = {{A Multi-Domain Intervention Protocol for the Potential Reversal of Cognitive Frailty: "WE-RISE" Randomized Controlled Trial}},
  journal = {Frontiers in public health},
  year    = {2020},
  doi     = {10.3389/fpubh.2020.00471},
  pmid    = {33014971},
  url     = {https://doi.org/10.3389/fpubh.2020.00471}
}

@article{mcmaster2018-30538436,
  author  = {McMaster, M. and Kim, S. and Clare, L. and Torres, S. J. and D'Este, C. and Anstey, K. J.},
  title   = {{Body, Brain, Life for Cognitive Decline (BBL-CD): protocol for a multidomain dementia risk reduction randomized controlled trial for subjective cognitive decline and mild cognitive impairment}},
  journal = {Clinical interventions in aging},
  year    = {2018},
  doi     = {10.2147/cia.s182046},
  pmid    = {30538436},
  url     = {https://doi.org/10.2147/cia.s182046}
}

@article{ponvel2025-40361174,
  author  = {Ponvel, Pavapriya and Shahar, Suzana and Singh, Devinder Kaur Ajit and Ludin, Arimi Fitri Mat and Subramaniam, Ponnusamy and Ibrahim, Norhayati and Haron, Hasnah and Ismail, Aniza Binti and others},
  title   = {{The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailty in Malaysia: The AGELESS Trial}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01722-w},
  pmid    = {40361174},
  url     = {https://doi.org/10.1186/s13195-025-01722-w}
}

@article{moon2025-39840755,
  author  = {Moon, So Young and Park, Yoo Kyoung and Jeong, Jee Hyang and Hong, Chang Hyung and Jung, Jiwoo and Na, Hae Ri and Cho, Soo Hyun and Kim, Hyun Sook and others},
  title   = {{South Korean study to prevent cognitive impairment and protect brain health through multidomain interventions via face‐to‐face and video communication platforms in mild cognitive impairment (SUPERBRAIN‐MEET): A randomized controlled trial}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.14517},
  pmid    = {39840755},
  url     = {https://doi.org/10.1002/alz.14517}
}

@article{lawrence2017-28583011,
  author  = {Lawrence, B. J. and Gasson, N. and Bucks, R. S. and Troeung, L. and Loftus, A. M.},
  title   = {{Cognitive Training and Noninvasive Brain Stimulation for Cognition in Parkinson's Disease: A Meta-analysis}},
  journal = {Neurorehabilitation and neural repair},
  year    = {2017},
  doi     = {10.1177/1545968317712468},
  pmid    = {28583011},
  url     = {https://doi.org/10.1177/1545968317712468}
}

@article{widmer2015-25447615,
  author  = {Widmer, R. J. and Flammer, A. J. and Lerman, L. O. and Lerman, A.},
  title   = {{The Mediterranean diet, its components, and cardiovascular disease}},
  journal = {The American journal of medicine},
  year    = {2015},
  doi     = {10.1016/j.amjmed.2014.10.014},
  pmid    = {25447615},
  url     = {https://doi.org/10.1016/j.amjmed.2014.10.014}
}

@article{belleville2008-17958927,
  author  = {Belleville, S.},
  title   = {{Cognitive training for persons with mild cognitive impairment}},
  journal = {International psychogeriatrics},
  year    = {2008},
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  pmid    = {17958927},
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}

@article{martinezgonzalez2016-27552476,
  author  = {Martinez-Gonzalez, M. A. and Martin-Calvo, N.},
  title   = {{Mediterranean diet and life expectancy; beyond olive oil, fruits, and vegetables}},
  journal = {Current opinion in clinical nutrition and metabolic care},
  year    = {2016},
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  pmid    = {27552476},
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}

@article{sugimoto2025-40065916,
  author  = {Sugimoto, Taiki and Uchida, Kazuaki and Sato, Kenji and Yokoyama, Yoko and Onoyama, Ayaka and Fujita, Kosuke and Kuroda, Yujiro and Wakayama, Satomu and others},
  title   = {{Factors associated with adherence to tablet‐based cognitive training: J‐MINT study}},
  journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
  year    = {2025},
  doi     = {10.1002/trc2.70062},
  pmid    = {40065916},
  url     = {https://doi.org/10.1002/trc2.70062}
}

@article{beyer2025-40378769,
  author  = {Beyer, Frauke and Kleine, Lukas and Zülke, Andrea E. and Luppa, Melanie and Mildner, Toralf and Gensichen, Jochen Stefan and Frese, Thomas and Czock, David and others},
  title   = {{Exploring the effect of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study}},
  journal = {NeuroImage Clinical},
  year    = {2025},
  doi     = {10.1016/j.nicl.2025.103796},
  pmid    = {40378769},
  url     = {https://doi.org/10.1016/j.nicl.2025.103796}
}

@article{amabili2025-40896828,
  author  = {Amabili, Giulio and Maranesi, Elvira and Margaritini, Arianna and Bonfigli, Anna Rita and Felici, Elisa and Barbarossa, Federico and Benadduci, Marco and Gosetto, Laëtitia and others},
  title   = {{Managing Cognitive Decline Through a Social Robot–Based Intervention: Protocol for the engAGE Proof of Concept and Randomized Controlled Trial}},
  journal = {JMIR Research Protocols},
  year    = {2025},
  doi     = {10.2196/67601},
  pmid    = {40896828},
  url     = {https://doi.org/10.2196/67601}
}

@article{tainta2025-40589624,
  author  = {Tainta, Mikel and Ecay‐Torres, Mirian and Barandiarán, Myriam and Estanga, Ainara and López, Carolina and Altuna, Miren and Iriondo, Ane and Saldias, Jon and others},
  title   = {{CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1539711},
  pmid    = {40589624},
  url     = {https://doi.org/10.3389/fnagi.2025.1539711}
}

@article{cherbuin2026-42098784,
  author  = {Cherbuin, Nicolas and Northey, Joseph M. and Walsh, Erin I. and Burns, Richard A. and Speer, Hollie and Lawlis, Nicholas and Namsrai, Tergel and Scott, Amanda and others},
  title   = {{A randomised controlled trial of physical activity and cognitive training in older adults: the PhABHeaD study}},
  journal = {Trials},
  year    = {2026},
  doi     = {10.1186/s13063-026-09681-9},
  pmid    = {42098784},
  url     = {https://doi.org/10.1186/s13063-026-09681-9}
}

@article{kang2025-40894462,
  author  = {Kang, Hyun and Ihara, Emily S. and Tompkins, Catherine J. and Lauber, Mckenzie},
  title   = {{Boosting Cognitive Training through Social Engagement: Impacts on Older Adults With Subjective Cognitive Decline}},
  journal = {Sage Open Aging},
  year    = {2025},
  doi     = {10.1177/30495334251366575},
  pmid    = {40894462},
  url     = {https://doi.org/10.1177/30495334251366575}
}

@article{silva2025-40640060,
  author  = {Silva, Ana Filipa and de Assis, Gilmara Gomes and Silva, Rui and Murawska‐Ciałowicz, Eugenia and Żurek, Grzegorz and Carvalho, José and Roriz, Mafalda Sofia and Azevedo, José and others},
  title   = {{The differential effect of strength, cognitive and aerobic training combinations on cognitive performance and functional abilities in elderly with cognitive decline: The Fit4Alz project}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100267},
  pmid    = {40640060},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100267}
}

@article{khan2026-41918619,
  author  = {Khan, Abdur Raheem and Aafreen, Aafreen and Khan, Ashfaque and Ganesh, G. Shankar and Aldhahi, Monira Ibrahim and Alshehri, Mohammed M. and Shaphe, Mohammad Abu},
  title   = {{Effects of aerobic exercise and computer-based cognitive training on cognition, functional independence, quality of life, and salivary cortisol levels in older adults with mild cognitive impairment: a randomized trial}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2026},
  doi     = {10.3389/fnagi.2026.1776069},
  pmid    = {41918619},
  url     = {https://doi.org/10.3389/fnagi.2026.1776069}
}

@article{jung2026-41938858,
  author  = {Jung, Jae Youn and Hong, Chang Hyung and Park, Yoo Kyoung and Moon, So Young and Jeong, Jee Hyang and Park, Hee Kyung and Choi, Seong Hye and Back, Joung Hwan and others},
  title   = {{Association of the Big Five personality traits with cognitive decline: a 24-week multidomain intervention study}},
  journal = {Frontiers in Psychiatry},
  year    = {2026},
  doi     = {10.3389/fpsyt.2026.1797887},
  pmid    = {41938858},
  url     = {https://doi.org/10.3389/fpsyt.2026.1797887}
}

@article{choi2025-41266554,
  author  = {Choi, Ha Yeong and Kim, Yeo Jin and Son, Dae‐Soon and Ahn, Moo Eob and Lee, Sang Gyu},
  title   = {{Effectiveness of a 52-week multidomain intervention to maintain cognitive function in patients with mild cognitive impairment: a randomized controlled trial}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-24865-0},
  pmid    = {41266554},
  url     = {https://doi.org/10.1038/s41598-025-24865-0}
}

@article{sugimoto2025-40046640,
  author  = {Sugimoto, Taiki and Uchida, Kazuaki and Yokoyama, Yoko and Onoyama, Ayaka and Fujita, Kosuke and Kuroda, Yujiro and Hinakura, Keigo and Ogawa, Susumu and others},
  title   = {{Adherence and aerobic exercise intensity in live online exercise sessions for older adults with mild cognitive impairment: Insights from the Japan-Multimodal Intervention Trial for the Prevention of Dementia}},
  journal = {Journal of Aging Research and Lifestyle},
  year    = {2025},
  doi     = {10.1016/j.jarlif.2025.100003},
  pmid    = {40046640},
  url     = {https://doi.org/10.1016/j.jarlif.2025.100003}
}

@article{vangils2026-41508135,
  author  = {van Gils, Veerle and Waterink, Lisa and Wimmers, S. C. P. M. and Jelsma, J.G.M. and de Vugt, Marjolein Elizabeth and Handels, Ron L. H. and Sikkes, Sietske A.M. and van der Flier, Wiesje M. and others},
  title   = {{The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-025-01947-9},
  pmid    = {41508135},
  url     = {https://doi.org/10.1186/s13195-025-01947-9}
}

@article{scheuermann2025-40306986,
  author  = {Scheuermann, Julia-Sophia and Scheerbaum, Petra and Liu, Yu and Ding, Yaping and Lu, Jianwen and Zhong, Ming and Su, Jian and Gefeller, Olaf and others},
  title   = {{SinoMAKS—protocol of a randomised controlled trial to evaluate the Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementia in Chinese nursing homes}},
  journal = {BMJ Open},
  year    = {2025},
  doi     = {10.1136/bmjopen-2024-093618},
  pmid    = {40306986},
  url     = {https://doi.org/10.1136/bmjopen-2024-093618}
}

@article{voigt2026-41958469,
  author  = {Voigt, Robin M. and Chaudhary, Adit and Naqib, Ankur D and Engen, Phillip A. and Adnan, Darbaz and Dhana, Klodian and Green, Stefan J. and Villanueva, Michelle and others},
  title   = {{Weight loss and metabolic improvements dominate the microbiome response in the MIND diet intervention: a randomized controlled trial}},
  journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
  year    = {2026},
  doi     = {10.1002/trc2.70239},
  pmid    = {41958469},
  url     = {https://doi.org/10.1002/trc2.70239}
}

@article{attarha2025-41084791,
  author  = {Attarha, Mouna and Pelegrino, Ana de Figueiredo and Ouellet, Lydia and Toussaint, Paule‐Joanne and Grant, Sarah-Jane and Van Vleet, Thomas and de Villers‐Sidani, Etienne},
  title   = {{Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial}},
  journal = {JMIR Serious Games},
  year    = {2025},
  doi     = {10.2196/75161},
  pmid    = {41084791},
  url     = {https://doi.org/10.2196/75161}
}

@article{ide2025-40397393,
  author  = {Ide, Keiko and Mizushima, Shunsaku and Saito, Kyoko and Suzuki, Hiroko and Chiba, Yuhei and Abe, Kie and Yoshimi, Asuka and Hishimoto, Akitoyo and others},
  title   = {{Japan-multimodal intervention trial for the prevention of dementia in older people with lifestyle-related diseases: A community-based, 18-month, randomized controlled trial}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251344222},
  pmid    = {40397393},
  url     = {https://doi.org/10.1177/13872877251344222}
}

@article{chiu2026-41781884,
  author  = {Chiu, Hsien-Chun and Hsieh, Yu-Wei and Cheng, Chia‐Hsiung},
  title   = {{Baseline predictors of neurophysiological response to combined physical and cognitive training in older adults with subjective cognitive decline}},
  journal = {BMC Geriatrics},
  year    = {2026},
  doi     = {10.1186/s12877-026-07270-8},
  pmid    = {41781884},
  url     = {https://doi.org/10.1186/s12877-026-07270-8}
}

@article{chung2025-41220868,
  author  = {Chung, S. S. and Kim, Bori R. and Moon, Sooin and Kim, Geon Ha},
  title   = {{Effects of a 12-Week Hybrid Analog–Digital Cognitive Training on Cognitively Unimpaired Older Adults: A Pilot Single-Blind Randomized Controlled Trial}},
  journal = {Dementia and Neurocognitive Disorders},
  year    = {2025},
  doi     = {10.12779/dnd.2025.24.4.301},
  pmid    = {41220868},
  url     = {https://doi.org/10.12779/dnd.2025.24.4.301}
}

@article{heffner2025-40454426,
  author  = {Heffner, Kathi L. and Crean, Hugh F. and Gallegos, Autumn M. and Quiñones-Cordero, Maria M and Weber, Miriam T. and Sörensen, Silvia and Lin, Rose Sin Yi and Podgorski, Carol Ann and others},
  title   = {{Speed of Processing Training for Stress Adaptation in Caregivers of a Family Member With Dementia: A Randomized Controlled Trial}},
  journal = {Innovation in Aging},
  year    = {2025},
  doi     = {10.1093/geroni/igaf033},
  pmid    = {40454426},
  url     = {https://doi.org/10.1093/geroni/igaf033}
}

@article{ye2025-39985041,
  author  = {Ye, Yi and Chen, Qing and Li, Ruixuan and Wang, Xiaoyi and Sun, Yueling and Li, Fangjiang and Liu, Xiaoping and Wang, Le and others},
  title   = {{The efficacy of computerized cognitive training in patients with coronary heart disease and cognitive impairment, no dementia: study protocol for a randomized controlled trial}},
  journal = {Trials},
  year    = {2025},
  doi     = {10.1186/s13063-025-08745-6},
  pmid    = {39985041},
  url     = {https://doi.org/10.1186/s13063-025-08745-6}
}