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% Source: https://alzhub.org/research?category=mechanisms
% 500 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{hung2022-35027502,
  author  = {Hung, C. C. and Chang, C. C. and Huang, C. W. and Nouchi, R. and Cheng, C. H.},
  title   = {{Gut microbiota in patients with Alzheimer's disease spectrum: a systematic review and meta-analysis}},
  journal = {Aging},
  year    = {2022},
  doi     = {10.18632/aging.203826},
  pmid    = {35027502},
  url     = {https://doi.org/10.18632/aging.203826}
}

@article{warren2026-41568738,
  author  = {Warren, Alison and Wynia, Zan and Corr, Patrick G and Devin, Mershad Fahim and Celikkol, Zeynep and Gordon, Lindsey and Farah, Mina and Karam, Michaela and others},
  title   = {{The microbiota-gut-brain axis in mild cognitive impairment and Alzheimer's disease: a scoping review of human studies}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71023},
  pmid    = {41568738},
  url     = {https://doi.org/10.1002/alz.71023}
}

@article{wang2025-40109019,
  author  = {Wang, Lisha and Sooram, Banesh and Kumar, Rajnish and Schedin-Weiss, Sophia and Tjernberg, Lars O and Winblad, Bengt},
  title   = {{Tau degradation in Alzheimer's disease: Mechanisms and therapeutic opportunities}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70048},
  pmid    = {40109019},
  url     = {https://doi.org/10.1002/alz.70048}
}

@article{prins2021-34044875,
  author  = {Prins, N. D. and Harrison, J. E. and Chu, H. M. and Blackburn, K. and Alam, J. J. and Scheltens, P. and {REVERSE-SD Study Investigators}},
  title   = {{A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00843-2},
  pmid    = {34044875},
  url     = {https://doi.org/10.1186/s13195-021-00843-2}
}

@article{nelson2022-35697880,
  author  = {Nelson, P. T. and Brayne, C. and Flanagan, M. E. and Abner, E. L. and Agrawal, S. and Attems, J. and Castellani, R. J. and Corrada, M. M. and others},
  title   = {{Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts}},
  journal = {Acta neuropathologica},
  year    = {2022},
  doi     = {10.1007/s00401-022-02444-1},
  pmid    = {35697880},
  url     = {https://doi.org/10.1007/s00401-022-02444-1}
}

@article{nilsson2024-38325331,
  author  = {Nilsson, J. and Pichet Binette, A. and Palmqvist, S. and Brum, W. S. and Janelidze, S. and Ashton, N. J. and Spotorno, N. and Stomrud, E. and others},
  title   = {{Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases}},
  journal = {Brain : a journal of neurology},
  year    = {2024},
  doi     = {10.1093/brain/awae032},
  pmid    = {38325331},
  url     = {https://doi.org/10.1093/brain/awae032}
}

@article{fei2023-36990042,
  author  = {Fei, Yuzhe and Wang, Ruiru and Lu, Jiachun and Peng, Songhao and Yang, Song and Wang, Yiting and Zheng, Kaixuan and Li, Ran and others},
  title   = {{Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment}},
  journal = {Geriatric nursing (New York, N.Y.)},
  year    = {2023},
  doi     = {10.1016/j.gerinurse.2023.03.006},
  pmid    = {36990042},
  url     = {https://doi.org/10.1016/j.gerinurse.2023.03.006}
}

@article{hilgert2023-39295910,
  author  = {Hilgert, Sabrina Sehn and Dias, Daniel Penteado Martins},
  title   = {{The intestinal microbiota as an ally in the treatment of Alzheimer's disease}},
  journal = {Gut microbiome (Cambridge, England)},
  year    = {2023},
  doi     = {10.1017/gmb.2023.8},
  pmid    = {39295910},
  url     = {https://doi.org/10.1017/gmb.2023.8}
}

@article{zhang2021-32576641,
  author  = {Zhang, B. and Wang, H. E. and Bai, Y. M. and Tsai, S. J. and Su, T. P. and Chen, T. J. and Wang, Y. P. and Chen, M. H.},
  title   = {{Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study}},
  journal = {Gut},
  year    = {2021},
  doi     = {10.1136/gutjnl-2020-320789},
  pmid    = {32576641},
  url     = {https://doi.org/10.1136/gutjnl-2020-320789}
}

@article{ticinesi2018-30214170,
  author  = {Ticinesi, A. and Tana, C. and Nouvenne, A. and Prati, B. and Lauretani, F. and Meschi, T.},
  title   = {{Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review}},
  journal = {Clinical interventions in aging},
  year    = {2018},
  doi     = {10.2147/cia.s139163},
  pmid    = {30214170},
  url     = {https://doi.org/10.2147/cia.s139163}
}

@article{noble2014-25522313,
  author  = {Noble, J. M. and Scarmeas, N. and Celenti, R. S. and Elkind, M. S. and Wright, C. B. and Schupf, N. and Papapanou, P. N.},
  title   = {{Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease}},
  journal = {PloS one},
  year    = {2014},
  doi     = {10.1371/journal.pone.0114959},
  pmid    = {25522313},
  url     = {https://doi.org/10.1371/journal.pone.0114959}
}

@article{horie2025-40164726,
  author  = {Horie, Kanta and Salvadó, Gemma and Koppisetti, Rama K. and Janelidze, Shorena and Barthélemy, Nicolas R. and He, Yingxin and Sato, Chihiro and Gordon, Brian Andrew and others},
  title   = {{Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease}},
  journal = {Nature Medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03617-7},
  pmid    = {40164726},
  url     = {https://doi.org/10.1038/s41591-025-03617-7}
}

@article{planche2022-35592489,
  author  = {Planche, V. and Manjon, J. V. and Mansencal, B. and Lanuza, E. and Tourdias, T. and Catheline, G. and Coupé, P.},
  title   = {{Structural progression of Alzheimer's disease over decades: the MRI staging scheme}},
  journal = {Brain communications},
  year    = {2022},
  doi     = {10.1093/braincomms/fcac109},
  pmid    = {35592489},
  url     = {https://doi.org/10.1093/braincomms/fcac109}
}

@article{ma2024-39577923,
  author  = {Ma, Y. and Farris, C. M. and Weber, S. and Schade, S. and Nguyen, H. and Pérez-Soriano, A. and Giraldo, D. M. and Fernández, M. and others},
  title   = {{Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study}},
  journal = {The Lancet. Neurology},
  year    = {2024},
  doi     = {10.1016/s1474-4422(24)00395-8},
  pmid    = {39577923},
  url     = {https://doi.org/10.1016/s1474-4422(24)00395-8}
}

@article{chin2020-33260030,
  author  = {Chin, K. S. and Yassi, N. and Churilov, L. and Masters, C. L. and Watson, R.},
  title   = {{Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis}},
  journal = {Parkinsonism \& related disorders},
  year    = {2020},
  doi     = {10.1016/j.parkreldis.2020.09.030},
  pmid    = {33260030},
  url     = {https://doi.org/10.1016/j.parkreldis.2020.09.030}
}

@article{scheltens2018-30309389,
  author  = {Scheltens, P. and Hallikainen, M. and Grimmer, T. and Duning, T. and Gouw, A. A. and Teunissen, C. E. and Wink, A. M. and Maruff, P. and others},
  title   = {{Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0431-6},
  pmid    = {30309389},
  url     = {https://doi.org/10.1186/s13195-018-0431-6}
}

@article{rouskas2025-41011443,
  author  = {Rouskas, Konstantinos and Mamalaki, Eirini and Ntanasi, Eva and Pantoura, Marianna and Anezaki, Maria and Emmanouil, Christina and Novau-Ferré, Nil and Bulló, Mònica and others},
  title   = {{Gut Microbiome Alterations in Mild Cognitive Impairment: Findings from the ALBION Greek Cohort}},
  journal = {Microorganisms},
  year    = {2025},
  doi     = {10.3390/microorganisms13092112},
  pmid    = {41011443},
  url     = {https://doi.org/10.3390/microorganisms13092112}
}

@article{hardy2002-12130773,
  author  = {Hardy, John and Selkoe, Dennis J.},
  title   = {{The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics}},
  journal = {Science},
  year    = {2002},
  doi     = {10.1126/science.1072994},
  pmid    = {12130773},
  url     = {https://doi.org/10.1126/science.1072994}
}

@article{vassar1999-10531052,
  author  = {Vassar, Robert J. and Bennett, Brian D. and Babu‐Khan, Safura and Kahn, Steve and Mendiaz, Elizabeth A. and Denis, Paul E. and Teplow, David B. and Ross, Sandra L. and others},
  title   = {{β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE}},
  journal = {Science},
  year    = {1999},
  doi     = {10.1126/science.286.5440.735},
  pmid    = {10531052},
  url     = {https://doi.org/10.1126/science.286.5440.735}
}

@article{sreedharan2008-18309045,
  author  = {Sreedharan, Jemeen and Blair, Ian P. and Tripathi, Vineeta B. and Hu, Xun and Vance, Caroline A. and Rogelj, Boris and Ackerley, Steven and Durnall, Jennifer C. and others},
  title   = {{TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis}},
  journal = {Science},
  year    = {2008},
  doi     = {10.1126/science.1154584},
  pmid    = {18309045},
  url     = {https://doi.org/10.1126/science.1154584}
}

@article{chi2017-27522059,
  author  = {Chi, G. C. and Fitzpatrick, A. L. and Sharma, M. and Jenny, N. S. and Lopez, O. L. and DeKosky, S. T.},
  title   = {{Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults}},
  journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
  year    = {2017},
  doi     = {10.1093/gerona/glw155},
  pmid    = {27522059},
  url     = {https://doi.org/10.1093/gerona/glw155}
}

@article{mathys2019-31042697,
  author  = {Mathys, Hansruedi and Dávila-Velderrain, José and Peng, Zhuyu and Gao, Fan and Mohammadi, Shahin and Young, Jennie Z. and Menon, Madhvi and He, Liang and Abdurrob, Fatema and Jiang, Xueqiao and Martorell, Anthony J. and Ransohoff, Richard M. and Hafler, Brian P. and Bennett, David Alan and Kellis, Manolis and Tsai, Li‐Huei},
  title   = {{Single-cell transcriptomic analysis of Alzheimer’s disease}},
  journal = {Nature},
  year    = {2019},
  doi     = {10.1038/s41586-019-1195-2},
  pmid    = {31042697},
  url     = {https://doi.org/10.1038/s41586-019-1195-2}
}

@article{pusil2019-31633176,
  author  = {Pusil, S. and López, M. E. and Cuesta, P. and Bruña, R. and Pereda, E. and Maestú, F.},
  title   = {{Hypersynchronization in mild cognitive impairment: the 'X' model}},
  journal = {Brain : a journal of neurology},
  year    = {2019},
  doi     = {10.1093/brain/awz320},
  pmid    = {31633176},
  url     = {https://doi.org/10.1093/brain/awz320}
}

@article{zhou2025-39662839,
  author  = {Zhou, Xuan-Peng and Sun, Luan-Biao and Liu, Wen-Hao and Zhu, Wu-Ming and Li, Lin-Chun and Song, Xin-Yuan and Xing, Jian-Peng and Gao, Shuo-Hui},
  title   = {{The complex relationship between gut microbiota and Alzheimer's disease: A systematic review}},
  journal = {Ageing research reviews},
  year    = {2025},
  doi     = {10.1016/j.arr.2024.102637},
  pmid    = {39662839},
  url     = {https://doi.org/10.1016/j.arr.2024.102637}
}

@article{barthelemy2020-32057125,
  author  = {Barthélemy, N. R. and Liu, H. and Lu, W. and Kotzbauer, P. T. and Bateman, R. J. and Lucey, B. P.},
  title   = {{Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid}},
  journal = {Annals of neurology},
  year    = {2020},
  doi     = {10.1002/ana.25702},
  pmid    = {32057125},
  url     = {https://doi.org/10.1002/ana.25702}
}

@article{mormino2016-27548655,
  author  = {Mormino, E. C. and Papp, K. V. and Rentz, D. M. and Schultz, A. P. and LaPoint, M. and Amariglio, R. and Hanseeuw, B. and Marshall, G. A. and others},
  title   = {{Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals}},
  journal = {JAMA neurology},
  year    = {2016},
  doi     = {10.1001/jamaneurol.2016.2237},
  pmid    = {27548655},
  url     = {https://doi.org/10.1001/jamaneurol.2016.2237}
}

@article{shankar2008-18568035,
  author  = {Shankar, Ganesh M. and Li, Shaomin and Mehta, Tapan and García-Muñoz, Amaya and Shepardson, Nina E. and Smith, Imelda M. and Brett, Francesca M. and Farrell, Michael Anthony and Rowan, Michael J. and Lemere, Cynthia Ann and Regan, Ciaran M. and Walsh, Dominic M. and Sabatini, Bernardo Luis and Selkoe, Dennis J.},
  title   = {{Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory}},
  journal = {Nature Medicine},
  year    = {2008},
  doi     = {10.1038/nm1782},
  pmid    = {18568035},
  url     = {https://doi.org/10.1038/nm1782}
}

@article{cordero2022-35367961,
  author  = {Cordero, Elisa Marina González and Cuevas-Budhart, Miguel Angel and Morán, Diana Pérez and Villeda, Miguel Angel Trejo and Gª-Madrid, Mercedes Gomez-Del-Pulgar},
  title   = {{Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-215224},
  pmid    = {35367961},
  url     = {https://doi.org/10.3233/jad-215224}
}

@article{gibson2020-33074237,
  author  = {Gibson, G. E. and Luchsinger, J. A. and Cirio, R. and Chen, H. and Franchino-Elder, J. and Hirsch, J. A. and Bettendorff, L. and Chen, Z. and others},
  title   = {{Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200896},
  pmid    = {33074237},
  url     = {https://doi.org/10.3233/jad-200896}
}

@article{kang2009-19779148,
  author  = {Kang, Jae-Eun and Lim, Miranda M. and Bateman, Randall John and Lee, James J. and Smyth, Liam P. and Cirrito, John R. and Fujiki, Nobuhiro and Nishino, Seiji and Holtzman, David M.},
  title   = {{Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle}},
  journal = {Science},
  year    = {2009},
  doi     = {10.1126/science.1180962},
  pmid    = {19779148},
  url     = {https://doi.org/10.1126/science.1180962}
}

@article{portelius2015-26373605,
  author  = {Portelius, E. and Zetterberg, H. and Skillbäck, T. and Törnqvist, U. and Andreasson, U. and Trojanowski, J. Q. and Weiner, M. W. and Shaw, L. M. and others},
  title   = {{Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2015},
  doi     = {10.1093/brain/awv267},
  pmid    = {26373605},
  url     = {https://doi.org/10.1093/brain/awv267}
}

@article{brendel2020-33165511,
  author  = {Brendel, M. and Barthel, H. and van Eimeren, T. and Marek, K. and Beyer, L. and Song, M. and Palleis, C. and Gehmeyr, M. and others},
  title   = {{Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.2526},
  pmid    = {33165511},
  url     = {https://doi.org/10.1001/jamaneurol.2020.2526}
}

@article{chatterjee2024-38890531,
  author  = {Chatterjee, M. and Özdemir, S. and Fritz, C. and Möbius, W. and Kleineidam, L. and Mandelkow, E. and Biernat, J. and Doğdu, C. and others},
  title   = {{Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS}},
  journal = {Nature medicine},
  year    = {2024},
  doi     = {10.1038/s41591-024-02937-4},
  pmid    = {38890531},
  url     = {https://doi.org/10.1038/s41591-024-02937-4}
}

@article{xu2025-40394891,
  author  = {Xu, Xiaomeng and Yang, Xinyuan and Zhang, Junfang and Wang, Yan and Selim, Magdy H. and Zheng, Yingting and Shen, Ruinan and Sun, Lipeng and others},
  title   = {{Choroid plexus free‐water correlates with glymphatic function in Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70239},
  pmid    = {40394891},
  url     = {https://doi.org/10.1002/alz.70239}
}

@article{hardy1992-1566067,
  author  = {Hardy, John and Higgins, Gerald A.},
  title   = {{Alzheimer's Disease: The Amyloid Cascade Hypothesis}},
  journal = {Science},
  year    = {1992},
  doi     = {10.1126/science.1566067},
  pmid    = {1566067},
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}

@article{selkoe2016-27025652,
  author  = {Selkoe, Dennis J. and Hardy, John},
  title   = {{The amyloid hypothesis of Alzheimer's disease at 25 years}},
  journal = {EMBO Molecular Medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201606210},
  pmid    = {27025652},
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}

@article{anita2022-34808290,
  author  = {Anita, N. Z. and Zebarth, J. and Chan, B. and Wu, C. Y. and Syed, T. and Shahrul, D. and Nguyen, M. M. and Pakosh, M. and others},
  title   = {{Inflammatory markers in type 2 diabetes with vs. without cognitive impairment; a systematic review and meta-analysis}},
  journal = {Brain, behavior, and immunity},
  year    = {2022},
  doi     = {10.1016/j.bbi.2021.11.005},
  pmid    = {34808290},
  url     = {https://doi.org/10.1016/j.bbi.2021.11.005}
}

@article{holland2022-34398211,
  author  = {Holland, N. and Malpetti, M. and Rittman, T. and Mak, E. E. and Passamonti, L. and Kaalund, S. S. and Hezemans, F. H. and Jones, P. S. and others},
  title   = {{Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awab282},
  pmid    = {34398211},
  url     = {https://doi.org/10.1093/brain/awab282}
}

@article{xie2013-24136970,
  author  = {Xie, Lulu and Kang, Hongyi and Xu, Qiwu and Chen, Michael J. and Liao, Yonghong and Thiyagarajan, Meenakshisundaram and O’Donnell, John and Christensen, Daniel J. and Nicholson, Charles and Iliff, Jeffrey J. and Takano, Takahiro and Deane, Rashid and Nedergaard, Maiken},
  title   = {{Sleep Drives Metabolite Clearance from the Adult Brain}},
  journal = {Science},
  year    = {2013},
  doi     = {10.1126/science.1241224},
  pmid    = {24136970},
  url     = {https://doi.org/10.1126/science.1241224}
}

@article{mawuenyega2010-21148344,
  author  = {Mawuenyega, Kwasi G. and Sigurdson, Wendy C. and Ovod, Vitaliy and Munsell, Ling Y. and Kasten, Tom P. and Morris, John C. and Yarasheski, Kevin E. and Bateman, Randall John},
  title   = {{Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease}},
  journal = {Science},
  year    = {2010},
  doi     = {10.1126/science.1197623},
  pmid    = {21148344},
  url     = {https://doi.org/10.1126/science.1197623}
}

@article{polymenidou2011-21358643,
  author  = {Polymenidou, Magdalini and Lagier‐Tourenne, Clotilde and Hutt, Kasey R. and Huelga, Stephanie C. and Moran, Jacqueline and Liang, Tiffany Y and Ling, Shuo‐Chien and Sun, Eveline and Wancewicz, Edward V. and Mazur, Curt and Kordasiewicz, Holly B. and Sedaghat, Yalda and Donohue, John Paul and Shiue, Lily and Bennett, C. Frank and Yeo, Gene Wei-Ming and Cleveland, Don W.},
  title   = {{Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43}},
  journal = {Nature Neuroscience},
  year    = {2011},
  doi     = {10.1038/nn.2779},
  pmid    = {21358643},
  url     = {https://doi.org/10.1038/nn.2779}
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@article{liu2026-42325435,
  author  = {Liu, Chenyu and Zhu, Zihan and Lin, Huang and Bush, William S and Jenq, Robert R and Cominelli, Fabio and Pillai, Jagan A and Haines, Jonathan L and others},
  title   = {{The gut-brain axis in Alzheimer's disease: early detection, microbial metabolites, mechanisms, and therapeutic opportunities}},
  journal = {Frontiers in molecular biosciences},
  year    = {2026},
  doi     = {10.3389/fmolb.2026.1735332},
  pmid    = {42325435},
  url     = {https://doi.org/10.3389/fmolb.2026.1735332}
}

@article{ajith2026-41074715,
  author  = {Ajith, Thekkuttuparambil Ananthanarayanan and Sreejith, Jagal Kishore},
  title   = {{Microbiota-gut-brain axis and probiotics: potential therapeutic strategies for treating Alzheimer's disease}},
  journal = {Nutritional neuroscience},
  year    = {2026},
  doi     = {10.1080/1028415x.2025.2567429},
  pmid    = {41074715},
  url     = {https://doi.org/10.1080/1028415x.2025.2567429}
}

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@article{forman2021-34194012,
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  year    = {2021},
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@article{yan2021-33536413,
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  title   = {{Ferroptosis: mechanisms and links with diseases}},
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@article{moujalled2021-34099897,
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  title   = {{Molecular mechanisms of cell death in neurological diseases}},
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  year    = {2021},
  doi     = {10.1038/s41418-021-00814-y},
  pmid    = {34099897},
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@article{park2021-33774476,
  author  = {Park, M. W. and Cha, H. W. and Kim, J. and Kim, J. H. and Yang, H. and Yoon, S. and Boonpraman, N. and Yi, S. S. and others},
  title   = {{NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases}},
  journal = {Redox biology},
  year    = {2021},
  doi     = {10.1016/j.redox.2021.101947},
  pmid    = {33774476},
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@article{nakhal2024-39459534,
  author  = {Nakhal, Mohammed M and Yassin, Lidya K and Alyaqoubi, Rana and Saeed, Sara and Alderei, Alreem and Alhammadi, Alya and Alshehhi, Mirah and Almehairbi, Afra and others},
  title   = {{The Microbiota-Gut-Brain Axis and Neurological Disorders: A Comprehensive Review}},
  journal = {Life (Basel, Switzerland)},
  year    = {2024},
  doi     = {10.3390/life14101234},
  pmid    = {39459534},
  url     = {https://doi.org/10.3390/life14101234}
}

@article{faysal2025-40908772,
  author  = {Faysal, Md and Zehravi, Mehrukh and Sutradhar, Baishakhi and Amin, Md Al and Shanmugarajan, Thukani Sathanantham and Arjun, Uppuluri Varuna Naga Venkata and Ethiraj, Susithra and Durairaj, Akiladevi and others},
  title   = {{The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders}},
  journal = {CNS neuroscience \& therapeutics},
  year    = {2025},
  doi     = {10.1111/cns.70593},
  pmid    = {40908772},
  url     = {https://doi.org/10.1111/cns.70593}
}

@article{cocean2024-38914414,
  author  = {Cocean, Ana-Maria and Vodnar, Dan Cristian},
  title   = {{Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health}},
  journal = {Progress in neuro-psychopharmacology \& biological psychiatry},
  year    = {2024},
  doi     = {10.1016/j.pnpbp.2024.111073},
  pmid    = {38914414},
  url     = {https://doi.org/10.1016/j.pnpbp.2024.111073}
}

@article{liao2024-38488562,
  author  = {Liao, Wang and Wei, Jiana and Liu, Chongxu and Luo, Haoyu and Ruan, Yuting and Mai, Yingren and Yu, Qun and Cao, Zhiyu and others},
  title   = {{Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis}},
  journal = {Neural regeneration research},
  year    = {2024},
  doi     = {10.4103/1673-5374.391310},
  pmid    = {38488562},
  url     = {https://doi.org/10.4103/1673-5374.391310}
}

@article{borregoruiz2025-40600213,
  author  = {Borrego-Ruiz, Alejandro and Borrego, Juan J},
  title   = {{Human oral microbiome and its influence on mental health and brain disorders}},
  journal = {AIMS microbiology},
  year    = {2025},
  doi     = {10.3934/microbiol.2025013},
  pmid    = {40600213},
  url     = {https://doi.org/10.3934/microbiol.2025013}
}

@article{yassin2025-41104042,
  author  = {Yassin, Lidya K and Skrabulyte-Barbulescu, Jurga and Alshamsi, Shamsa H and Saeed, Sara and Alkuwaiti, Shamma H and Almazrouei, Saif and Alnuaimi, Abeer and BaniYas, Shamsa and others},
  title   = {{The microbiota-gut-brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention}},
  journal = {Frontiers in aging neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1667448},
  pmid    = {41104042},
  url     = {https://doi.org/10.3389/fnagi.2025.1667448}
}

@article{shabani2025-40395507,
  author  = {Shabani, Mohammad and Ghoshehy, Ali and Mottaghi, Amir Mohammad and Chegini, Zahra and Kerami, Azam and Shariati, Aref and Moghadam, Majid Taati},
  title   = {{The relationship between gut microbiome and human diseases: mechanisms, predisposing factors and potential intervention}},
  journal = {Frontiers in cellular and infection microbiology},
  year    = {2025},
  doi     = {10.3389/fcimb.2025.1516010},
  pmid    = {40395507},
  url     = {https://doi.org/10.3389/fcimb.2025.1516010}
}

@article{cerullo2025-40362738,
  author  = {Cerullo, Miriam and Armeli, Federica and Mengoni, Beatrice and Menin, Martina and Crudeli, Maria Luisa and Businaro, Rita},
  title   = {{Curcumin Modulation of the Gut-Brain Axis for Neuroinflammation and Metabolic Disorders Prevention and Treatment}},
  journal = {Nutrients},
  year    = {2025},
  doi     = {10.3390/nu17091430},
  pmid    = {40362738},
  url     = {https://doi.org/10.3390/nu17091430}
}

@article{liang2024-39403057,
  author  = {Liang, Chang and Pereira, Resel and Zhang, Yan and Rojas, Olga L},
  title   = {{Gut Microbiome in Alzheimer's Disease: from Mice to Humans}},
  journal = {Current neuropharmacology},
  year    = {2024},
  doi     = {10.2174/1570159x22666240308090741},
  pmid    = {39403057},
  url     = {https://doi.org/10.2174/1570159x22666240308090741}
}

@article{huarcaya2025-40396795,
  author  = {Huarcaya, Lester Raymundo Dominguez},
  title   = {{Gut Microbiota and Alzheimer Disease}},
  journal = {Acta neurologica Taiwanica},
  year    = {2025},
  doi     = {10.4103/ant.ant_113_0046},
  pmid    = {40396795},
  url     = {https://doi.org/10.4103/ant.ant_113_0046}
}

@article{momen2024-39125436,
  author  = {Momen, Yomna S and Mishra, Jayshree and Kumar, Narendra},
  title   = {{Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer's Disease}},
  journal = {Nutrients},
  year    = {2024},
  doi     = {10.3390/nu16152558},
  pmid    = {39125436},
  url     = {https://doi.org/10.3390/nu16152558}
}

@article{qin2025-41425927,
  author  = {Qin, Ruiqi and Li, Chaofan and Yuan, Xingxing and Chen, Yinghua},
  title   = {{Microbiome-targeted Alzheimer's interventions via gut-brain axis}},
  journal = {Frontiers in microbiology},
  year    = {2025},
  doi     = {10.3389/fmicb.2025.1729708},
  pmid    = {41425927},
  url     = {https://doi.org/10.3389/fmicb.2025.1729708}
}

@article{mukherjee2025-40712930,
  author  = {Mukherjee, Upasana and Reddy, P Hemachandra},
  title   = {{Gut-brain relationship in dementia and Alzheimer's disease: Impact on stress and immunity}},
  journal = {Ageing research reviews},
  year    = {2025},
  doi     = {10.1016/j.arr.2025.102843},
  pmid    = {40712930},
  url     = {https://doi.org/10.1016/j.arr.2025.102843}
}

@article{khan2024-38237031,
  author  = {Khan, Romeesa and Di Gesù, Claudia M and Lee, Juneyoung and McCullough, Louise D},
  title   = {{The contribution of age-related changes in the gut-brain axis to neurological disorders}},
  journal = {Gut microbes},
  year    = {2024},
  doi     = {10.1080/19490976.2024.2302801},
  pmid    = {38237031},
  url     = {https://doi.org/10.1080/19490976.2024.2302801}
}

@article{wu2024-38008941,
  author  = {Wu, Shijing and Yang, Liangfang and Fu, Yiwei and Liao, Zhimin and Cai, De and Liu, Zhou},
  title   = {{Intestinal Barrier Function and Neurodegenerative Disease}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2024},
  doi     = {10.2174/0118715273264097231116103948},
  pmid    = {38008941},
  url     = {https://doi.org/10.2174/0118715273264097231116103948}
}

@article{qu2024-37728579,
  author  = {Qu, Linkai and Li, Yanwei and Liu, Fan and Fang, Yimeng and He, Jiaxuan and Ma, Jiahui and Xu, Ting and Wang, Lei and others},
  title   = {{Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential}},
  journal = {Aging and disease},
  year    = {2024},
  doi     = {10.14336/ad.2023.0823-2},
  pmid    = {37728579},
  url     = {https://doi.org/10.14336/ad.2023.0823-2}
}

@article{zhao2025-41298902,
  author  = {Zhao, Yuhai and Taylor, Christopher M and Lukiw, Walter J and Bazan, Nicolas G},
  title   = {{Dietary fiber modulates gut microbiota and lipid metabolism ameliorating Alzheimer's pathology in 5xFAD mice}},
  journal = {Scientific reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-26315-3},
  pmid    = {41298902},
  url     = {https://doi.org/10.1038/s41598-025-26315-3}
}

@article{hochuli2024-38455083,
  author  = {Hochuli, Nathaniel and Kadyan, Saurabh and Park, Gwoncheol and Patoine, Cole and Nagpal, Ravinder},
  title   = {{Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer's pathophysiology}},
  journal = {Microbiome research reports},
  year    = {2024},
  doi     = {10.20517/mrr.2023.39},
  pmid    = {38455083},
  url     = {https://doi.org/10.20517/mrr.2023.39}
}

@article{dziedziak2025-41007667,
  author  = {Dziedziak, Marta and Mytych, Agata and Szyller, Hubert Paweł and Lasocka, Maria and Augustynowicz, Gabriela and Szydziak, Joanna and Hrapkowicz, Aleksandra and Dyda, Maciej and others},
  title   = {{Gut Microbiota in Psychiatric and Neurological Disorders: Current Insights and Therapeutic Implications}},
  journal = {Biomedicines},
  year    = {2025},
  doi     = {10.3390/biomedicines13092104},
  pmid    = {41007667},
  url     = {https://doi.org/10.3390/biomedicines13092104}
}

@article{dandamudi2024-39588438,
  author  = {Dandamudi, Bindu Jyothi and Dimaano, Kathrina Antheia M and Shah, Nensi and AlQassab, Osamah and Al-Sulaitti, Zainab and Nelakuditi, Bhavana and Mohammed, Lubna},
  title   = {{Neurodegenerative Disorders and the Gut-Microbiome-Brain Axis: A Literature Review}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.72427},
  pmid    = {39588438},
  url     = {https://doi.org/10.7759/cureus.72427}
}

@article{zou2024-38495755,
  author  = {Zou, Xinfu and Zou, Guoqiang and Zou, Xinyan and Wang, Kangfeng and Chen, Zetao},
  title   = {{Gut microbiota and its metabolites in Alzheimer's disease: from pathogenesis to treatment}},
  journal = {PeerJ},
  year    = {2024},
  doi     = {10.7717/peerj.17061},
  pmid    = {38495755},
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}

@article{huang2024-39245190,
  author  = {Huang, Jiayuan and Liu, Sanxin and Li, Peijie and Wei, Lei and Lin, Gan and Lin, Jiahao and Luo, Yuting and Liu, Yixin and others},
  title   = {{Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease}},
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  year    = {2024},
  doi     = {10.1016/j.phrs.2024.107385},
  pmid    = {39245190},
  url     = {https://doi.org/10.1016/j.phrs.2024.107385}
}

@article{westfall2020-32310171,
  author  = {Westfall, Susan and Dinh, Duy M and Pasinetti, Giulio Maria},
  title   = {{Investigation of Potential Brain Microbiome in Alzheimer's Disease: Implications of Study Bias}},
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  year    = {2020},
  doi     = {10.3233/jad-191328},
  pmid    = {32310171},
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}

@article{oriordan2025-40442386,
  author  = {O'Riordan, Kenneth J and Aburto, Maria R and Nagpal, Jatin and Clarke, Gerard and Cryan, John F},
  title   = {{Microbiome: A Key Regulator of Body-Brain Interactions}},
  journal = {Advances in experimental medicine and biology},
  year    = {2025},
  doi     = {10.1007/978-3-031-89525-8_6},
  pmid    = {40442386},
  url     = {https://doi.org/10.1007/978-3-031-89525-8_6}
}

@article{zhang2024-39355779,
  author  = {Zhang, Shanshan and Lu, Jing and Jin, Ziqi and Xu, Hanying and Zhang, Dongmei and Chen, Jianan and Wang, Jian},
  title   = {{Gut microbiota metabolites: potential therapeutic targets for Alzheimer's disease?}},
  journal = {Frontiers in pharmacology},
  year    = {2024},
  doi     = {10.3389/fphar.2024.1459655},
  pmid    = {39355779},
  url     = {https://doi.org/10.3389/fphar.2024.1459655}
}

@article{mustafa2025-41276714,
  author  = {Mustafa, Mohammed Ahmed and Vadia, Nasir and Varma, Pooja and Al-Shaker, Hasnaawei and Mohanty, Biswaranjan and Dhyani, Archana and Kaur, Irwanjot and Chauhan, Ashish Singh and others},
  title   = {{The Gut-Brain Axis in Alzheimer's Disease: Exploring Microbial Influences and Therapeutic Strategies}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-05474-4},
  pmid    = {41276714},
  url     = {https://doi.org/10.1007/s12035-025-05474-4}
}

@article{vijayaram2025-41078543,
  author  = {Vijayaram, Srirengaraj and Mahendran, Karthikeyan and Razafindralambo, Hary and Ringø, Einar and Kannan, Suruli and Sun, Yun-Zhang},
  title   = {{Probiotics, gut microbiota, and brain health: Exploring therapeutic pathways}},
  journal = {AIMS microbiology},
  year    = {2025},
  doi     = {10.3934/microbiol.2025022},
  pmid    = {41078543},
  url     = {https://doi.org/10.3934/microbiol.2025022}
}

@article{guo2017-28386764,
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  title   = {{Roles of tau protein in health and disease}},
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  year    = {2017},
  doi     = {10.1007/s00401-017-1707-9},
  pmid    = {28386764},
  url     = {https://doi.org/10.1007/s00401-017-1707-9}
}

@article{prikhodko2024-39134419,
  author  = {Prikhodko, Olga and Freund, Ronald K and Sullivan, Emily and Kennedy, Matthew J and Dell'Acqua, Mark L},
  title   = {{Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2024},
  doi     = {10.1523/jneurosci.0675-24.2024},
  pmid    = {39134419},
  url     = {https://doi.org/10.1523/jneurosci.0675-24.2024}
}

@article{pereyra2025-40198223,
  author  = {Pereyra, Guadalupe and Mateo, María Inés and Miaja, Pablo and Martin-Bermejo, María Jesús and Martinez-Baños, Marcos and Klaassen, Remco and Gruart, Agnès and Rueda-Carrasco, Javier and others},
  title   = {{SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment}},
  journal = {Cell reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.115535},
  pmid    = {40198223},
  url     = {https://doi.org/10.1016/j.celrep.2025.115535}
}

@article{dilucente2024-38366025,
  author  = {Di Lucente, Jacopo and Persico, Giuseppe and Zhou, Zeyu and Jin, Lee-Way and Ramsey, Jon J and Rutkowsky, Jennifer M and Montgomery, Claire M and Tomilov, Alexey and others},
  title   = {{Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes}},
  journal = {Communications biology},
  year    = {2024},
  doi     = {10.1038/s42003-024-05860-z},
  pmid    = {38366025},
  url     = {https://doi.org/10.1038/s42003-024-05860-z}
}

@article{ebrahimi2025-41021123,
  author  = {Ebrahimi, Rasoul and Golzari, Zahra and Heidari-Foroozan, Mahsa and Khosravi, Abolfazl and Sharghi, Samin Ghaheri and Saleh, Mobina and Salarvandian, Shakiba and Esmaeilpour, Khadijeh},
  title   = {{Impaired Synaptic Plasticity Mechanisms in Alzheimer's Disease}},
  journal = {Metabolic brain disease},
  year    = {2025},
  doi     = {10.1007/s11011-025-01712-9},
  pmid    = {41021123},
  url     = {https://doi.org/10.1007/s11011-025-01712-9}
}

@article{ji2025-40993809,
  author  = {Ji, Miao-Jin and Li, Yun and Yang, Jiao and Wang, Kangjunjie and Sang, Shuning and Yang, Hong and Tian, Chenhao and Tang, Xin and others},
  title   = {{RNF168 dephosphorylation ameliorates cognitive decline in Aβ-based mouse models of Alzheimer's disease}},
  journal = {Acta neuropathologica communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02115-8},
  pmid    = {40993809},
  url     = {https://doi.org/10.1186/s40478-025-02115-8}
}

@article{fan2025-41029886,
  author  = {Fan, Xing and Wang, Hao and Guo, Cuiping and Huang, Shijia and Xia, Liye and Zhou, Zheng and Tao, Ran and Li, Mingzhe and others},
  title   = {{IRF1 ameliorates synaptic dysfunction through the modulation of O-GlcNAcylation on GluN1 subunit of NMDAR}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01857-w},
  pmid    = {41029886},
  url     = {https://doi.org/10.1186/s13195-025-01857-w}
}

@article{haseenap2024-39244567,
  author  = {Haseena P, A. and Basavaraju, Nimisha and Chandran, Mahesh and Jaleel, Abdul and Bennett, David A and Kommaddi, Reddy Peera},
  title   = {{Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01558-w},
  pmid    = {39244567},
  url     = {https://doi.org/10.1186/s13195-024-01558-w}
}

@article{zeng2024-38719948,
  author  = {Zeng, Juan and Hu, Xian-Feng and Sun, Dong-Sheng and Hong, Xiao-Yue and Ma, Jun-Zheng and Feng, Qiong},
  title   = {{Alzheimer-like behavior and synaptic dysfunction in 3 × Tg-AD mice are reversed with calcineurin inhibition}},
  journal = {Experimental brain research},
  year    = {2024},
  doi     = {10.1007/s00221-024-06841-8},
  pmid    = {38719948},
  url     = {https://doi.org/10.1007/s00221-024-06841-8}
}

@article{collingridge2025-39615648,
  author  = {Collingridge, Graham L},
  title   = {{Long-term potentiation in the hippocampus: From magnesium to memory}},
  journal = {Neuroscience},
  year    = {2025},
  doi     = {10.1016/j.neuroscience.2024.11.069},
  pmid    = {39615648},
  url     = {https://doi.org/10.1016/j.neuroscience.2024.11.069}
}

@article{ayala2024-38452814,
  author  = {Ayala, Ivan and Bahrami, Atousa and Pan, Yuting and Spencer, Callen and Flanagan, Margaret E and Mesulam, M-Marsel and Gefen, Tamar and Geula, Changiz},
  title   = {{Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy}},
  journal = {Neurochemistry international},
  year    = {2024},
  doi     = {10.1016/j.neuint.2024.105719},
  pmid    = {38452814},
  url     = {https://doi.org/10.1016/j.neuint.2024.105719}
}

@article{wang2024-38916730,
  author  = {Wang, Zijian and Pan, Jun-Ping and Geng, Jiayuan and Lv, Shijie and Chen, Guisi and Fang, Nian and Zhang, Zheng and Li, Junliang and others},
  title   = {{Nogo-A Drives Alzheimer's Disease Progression by Inducing Tauopathy Vulnerability}},
  journal = {Aging and disease},
  year    = {2024},
  doi     = {10.14336/ad.2024.0053},
  pmid    = {38916730},
  url     = {https://doi.org/10.14336/ad.2024.0053}
}

@article{shin2024-39085348,
  author  = {Shin, Kyung Chul and Moussa, Houda Yasmine Ali and Park, Yongsoo},
  title   = {{Cholesterol imbalance and neurotransmission defects in neurodegeneration}},
  journal = {Experimental \& molecular medicine},
  year    = {2024},
  doi     = {10.1038/s12276-024-01273-4},
  pmid    = {39085348},
  url     = {https://doi.org/10.1038/s12276-024-01273-4}
}

@article{bloemer2025-40984655,
  author  = {Bloemer, Jenna and Pinky, Priyanka D and Suppiramaniam, Vishnu and Reed, Miranda N},
  title   = {{Adiponectin Receptor Agonist Ameliorates Synaptic Dysfunction in 3xTg Alzheimer's Disease Mouse Model by Activation of AMPK}},
  journal = {CNS neuroscience \& therapeutics},
  year    = {2025},
  doi     = {10.1111/cns.70616},
  pmid    = {40984655},
  url     = {https://doi.org/10.1111/cns.70616}
}

@article{dasilva2024-38615035,
  author  = {da Silva, Marina I Oliveira and Santejo, Miguel and Babcock, Isaac W and Magalhães, Ana and Minamide, Laurie S and Won, Seok-Joon and Castillo, Erika and Gerhardt, Ellen and others},
  title   = {{α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway}},
  journal = {Cell death \& disease},
  year    = {2024},
  doi     = {10.1038/s41419-024-06630-9},
  pmid    = {38615035},
  url     = {https://doi.org/10.1038/s41419-024-06630-9}
}

@article{zhao2024-38819697,
  author  = {Zhao, Wenyan and Zhang, Wei and Hu, Yingying and Zhou, Yuliang and Zhao, Jinying and Li, Yahong and Xu, Zhipeng},
  title   = {{AdipoRon Ameliorates Synaptic Dysfunction and Inhibits tau Hyperphosphorylation through the AdipoR/AMPK/mTOR Pathway in T2DM Mice}},
  journal = {Neurochemical research},
  year    = {2024},
  doi     = {10.1007/s11064-024-04162-4},
  pmid    = {38819697},
  url     = {https://doi.org/10.1007/s11064-024-04162-4}
}

@article{wang2025-40003952,
  author  = {Wang, Yaxin and Zhao, Jinfeng and Zhao, Li},
  title   = {{L-Lactate Administration Improved Synaptic Plasticity and Cognition in Early 3xTg-AD Mice}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26041486},
  pmid    = {40003952},
  url     = {https://doi.org/10.3390/ijms26041486}
}

@article{balducci2025-39871396,
  author  = {Balducci, Claudia and Orsini, Franca and Cerovic, Milica and Beeg, Marten and Rocutto, Beatrice and Dacomo, Letizia and Masone, Antonio and Busani, Eleonora and others},
  title   = {{Tau oligomers impair memory and synaptic plasticity through the cellular prion protein}},
  journal = {Acta neuropathologica communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-01930-3},
  pmid    = {39871396},
  url     = {https://doi.org/10.1186/s40478-025-01930-3}
}

@article{ivanova2025-41096712,
  author  = {Ivanova, Anna V and Kutuzova, Alexandra D and Kuzmichev, Ilia A and Abakumov, Maxim A},
  title   = {{Alzheimer's Disease: From Molecular Mechanisms to Promising Therapeutic Strategies}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26199444},
  pmid    = {41096712},
  url     = {https://doi.org/10.3390/ijms26199444}
}

@article{ye2024-38869076,
  author  = {Ye, Yu and Jia, Penghui and Miao, Jiafan and Wang, Yicheng and Li, Zibo and Lin, Yuxin and He, Miao and Liu, Shurui and others},
  title   = {{CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity}},
  journal = {Autophagy},
  year    = {2024},
  doi     = {10.1080/15548627.2024.2367183},
  pmid    = {38869076},
  url     = {https://doi.org/10.1080/15548627.2024.2367183}
}

@article{mariner2024-37749371,
  author  = {Mariner, Blaise L and Rodriguez, Antonio S and Heath, Olivia C and McCormick, Mark A},
  title   = {{Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors}},
  journal = {GeroScience},
  year    = {2024},
  doi     = {10.1007/s11357-023-00938-8},
  pmid    = {37749371},
  url     = {https://doi.org/10.1007/s11357-023-00938-8}
}

@article{ferrari2024-38865459,
  author  = {Ferrari, Luca and Bauer, Bernd and Qiu, Yue and Schuschnig, Martina and Klotz, Sigrid and Anrather, Dorothea and Juretschke, Thomas and Beli, Petra and others},
  title   = {{Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion}},
  journal = {Science advances},
  year    = {2024},
  doi     = {10.1126/sciadv.adm8449},
  pmid    = {38865459},
  url     = {https://doi.org/10.1126/sciadv.adm8449}
}

@article{ryan2024-38101818,
  author  = {Ryan, Laura and Rubinsztein, David C},
  title   = {{The autophagy of stress granules}},
  journal = {FEBS letters},
  year    = {2024},
  doi     = {10.1002/1873-3468.14787},
  pmid    = {38101818},
  url     = {https://doi.org/10.1002/1873-3468.14787}
}

@article{kinger2024-38797543,
  author  = {Kinger, Sumit and Jagtap, Yuvraj Anandrao and Kumar, Prashant and Choudhary, Akash and Prasad, Amit and Prajapati, Vijay Kumar and Kumar, Amit and Mehta, Gunjan and others},
  title   = {{Proteostasis in neurodegenerative diseases}},
  journal = {Advances in clinical chemistry},
  year    = {2024},
  doi     = {10.1016/bs.acc.2024.04.002},
  pmid    = {38797543},
  url     = {https://doi.org/10.1016/bs.acc.2024.04.002}
}

@article{tangavelou2024-39596399,
  author  = {Tangavelou, Karthikeyan and Bhaskar, Kiran},
  title   = {{The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms252212335},
  pmid    = {39596399},
  url     = {https://doi.org/10.3390/ijms252212335}
}

@article{hu2025-40729740,
  author  = {Hu, Liubing and Li, Jianshuang and Guo, Haolin and Su, Lei and Dong, Peina and Huang, Juan and Liu, Yanyan and Liu, Xinjie and others},
  title   = {{SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40}},
  journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
  year    = {2025},
  doi     = {10.1002/advs.202503408},
  pmid    = {40729740},
  url     = {https://doi.org/10.1002/advs.202503408}
}

@article{endicott2024-39687864,
  author  = {Endicott, S Joseph},
  title   = {{Chaperone-mediated autophagy as a modulator of aging and longevity}},
  journal = {Frontiers in aging},
  year    = {2024},
  doi     = {10.3389/fragi.2024.1509400},
  pmid    = {39687864},
  url     = {https://doi.org/10.3389/fragi.2024.1509400}
}

@article{augur2025-40898372,
  author  = {Augur, Zachary M and Fogo, Garrett M and Arbery, Mason R and Stern, Andrew M and Benoit, Courtney R and Hsieh, Yi-Chen and Young-Pearse, Tracy L},
  title   = {{Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons}},
  journal = {Acta neuropathologica communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02103-y},
  pmid    = {40898372},
  url     = {https://doi.org/10.1186/s40478-025-02103-y}
}

@article{thapa2024-39216694,
  author  = {Thapa, Riya and Bhat, Asif Ahmad and Shahwan, Moyad and Ali, Haider and PadmaPriya, G and Bansal, Pooja and Rajotiya, Sumit and Barwal, Amit and others},
  title   = {{Proteostasis disruption and senescence in Alzheimer's disease pathways to neurodegeneration}},
  journal = {Brain research},
  year    = {2024},
  doi     = {10.1016/j.brainres.2024.149202},
  pmid    = {39216694},
  url     = {https://doi.org/10.1016/j.brainres.2024.149202}
}

@article{sun2025-41296937,
  author  = {Sun, Li and Chen, Chu},
  title   = {{Senescence in Aging and Alzheimer's Disease}},
  journal = {Aging and disease},
  year    = {2025},
  doi     = {10.14336/ad.2025.1201},
  pmid    = {41296937},
  url     = {https://doi.org/10.14336/ad.2025.1201}
}

@article{chinnathambi2025-40973404,
  author  = {Chinnathambi, Subashchandrabose},
  title   = {{Tau proteotasis in Alzheimer's disease}},
  journal = {Advances in protein chemistry and structural biology},
  year    = {2025},
  doi     = {10.1016/bs.apcsb.2024.09.003},
  pmid    = {40973404},
  url     = {https://doi.org/10.1016/bs.apcsb.2024.09.003}
}

@article{salcedotacuma2025-41071871,
  author  = {Salcedo-Tacuma, David and Asad, Nadeem and Islam, Md Qamrul and Anderson, Raymond and Smith, David M},
  title   = {{Hyperactive 20S proteasome enhances proteostasis and ERAD in C. elegans via degradation of intrinsically disordered proteins}},
  journal = {Science advances},
  year    = {2025},
  doi     = {10.1126/sciadv.adx3014},
  pmid    = {41071871},
  url     = {https://doi.org/10.1126/sciadv.adx3014}
}

@article{jamwal2025-41309196,
  author  = {Jamwal, Rajeshwer Singh and Sharma, Bhawani and Minerva and Gupta, Agamya and Misri, Swati and Shankaryan, Raju and Shah, Ruchi and Kumar, Rakesh},
  title   = {{Protein misfolding and its dual role in neurodegeneration and cancer progression}},
  journal = {Advances in protein chemistry and structural biology},
  year    = {2025},
  doi     = {10.1016/bs.apcsb.2025.10.001},
  pmid    = {41309196},
  url     = {https://doi.org/10.1016/bs.apcsb.2025.10.001}
}

@article{panwar2024-38570333,
  author  = {Panwar, Surbhi and Uniyal, Prerna and Kukreti, Neelima and Hashmi, Afreen and Verma, Shivani and Arya, Aanchal and Joshi, Gaurav},
  title   = {{Role of autophagy and proteostasis in neurodegenerative diseases: Exploring the therapeutic interventions}},
  journal = {Chemical biology \& drug design},
  year    = {2024},
  doi     = {10.1111/cbdd.14515},
  pmid    = {38570333},
  url     = {https://doi.org/10.1111/cbdd.14515}
}

@article{li2024-38486986,
  author  = {Li, Yixian and Yang, Peng and Meng, Ran and Xu, Shuting and Zhou, Lingling and Qian, Kang and Wang, Pengzhen and Cheng, Yunlong and others},
  title   = {{Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis}},
  journal = {Acta pharmaceutica Sinica. B},
  year    = {2024},
  doi     = {10.1016/j.apsb.2023.10.009},
  pmid    = {38486986},
  url     = {https://doi.org/10.1016/j.apsb.2023.10.009}
}

@article{hein2025-40558538,
  author  = {Hein, Zaw Myo and Vishnumukkala, Thirupathirao and Karikalan, Barani and Alkatiri, Aisyah and Hussan, Farida and Jagadeesan, Saravanan and Kamaruzzaman, Mohd Amir and Ramli, Muhammad Danial Che and others},
  title   = {{Autophagy and Alzheimer's Disease: Mechanisms and Impact Beyond the Brain}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14120911},
  pmid    = {40558538},
  url     = {https://doi.org/10.3390/cells14120911}
}

@article{hayat2025-41877687,
  author  = {Hayat, Bushra and Alone, Debasmita Pankaj},
  title   = {{Unfolded proteins and aggregates: The role of proteostasis in pseudoexfoliation pathology}},
  journal = {Molecular vision},
  year    = {2025},
  pmid    = {41877687}
}

@article{lin2024-39281281,
  author  = {Lin, Hongru and Zhang, Chen and Gao, Yehui and Zhou, Yi and Ma, Botian and Jiang, Jinyun and Long, Xue and Yimamu, Nuerziya and others},
  title   = {{HLH-30/TFEB modulates autophagy to improve proteostasis in Aβ transgenic Caenorhabditis elegans}},
  journal = {Frontiers in pharmacology},
  year    = {2024},
  doi     = {10.3389/fphar.2024.1433030},
  pmid    = {39281281},
  url     = {https://doi.org/10.3389/fphar.2024.1433030}
}

@article{ning2024-39522311,
  author  = {Ning, Zhenqiu and Zhong, Xiaoqin and Wang, Yu and Hu, Dafeng and Tang, Xialin and Deng, Minzhen},
  title   = {{Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice}},
  journal = {International immunopharmacology},
  year    = {2024},
  doi     = {10.1016/j.intimp.2024.113581},
  pmid    = {39522311},
  url     = {https://doi.org/10.1016/j.intimp.2024.113581}
}

@article{li2025-40414310,
  author  = {Li, Lili and Li, Shiyin and Cai, Lei and Yang, Xiaofeng and Feng, Yifeng and Zhang, Liying and He, Xiaofei and Li, Mingyue},
  title   = {{Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease}},
  journal = {Behavioural brain research},
  year    = {2025},
  doi     = {10.1016/j.bbr.2025.115650},
  pmid    = {40414310},
  url     = {https://doi.org/10.1016/j.bbr.2025.115650}
}

@article{cai2025-39945772,
  author  = {Cai, Zhangying and Wang, Shoutang and Cao, Siyan and Chen, Yun and Penati, Silvia and Peng, Vincent and Yuede, Carla M and Beatty, Wandy L and others},
  title   = {{Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control}},
  journal = {The Journal of experimental medicine},
  year    = {2025},
  doi     = {10.1084/jem.20230173},
  pmid    = {39945772},
  url     = {https://doi.org/10.1084/jem.20230173}
}

@article{waldherr2024-39060347,
  author  = {Waldherr, Sarah M and Han, Marina and Saxton, Aleen D and Vadset, Taylor A and McMillan, Pamela J and Wheeler, Jeanna M and Liachko, Nicole F and Kraemer, Brian C},
  title   = {{Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy}},
  journal = {Communications biology},
  year    = {2024},
  doi     = {10.1038/s42003-024-06570-2},
  pmid    = {39060347},
  url     = {https://doi.org/10.1038/s42003-024-06570-2}
}

@article{brehme2014-25437566,
  author  = {Brehme, Marc and Voisine, Cindy and Rolland, Thomas and Wachi, Shinichiro and Soper, James H. and Zhu, Yitan and Orton, Kai and Villella, Adriana and others},
  title   = {{A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease}},
  journal = {Cell Reports},
  year    = {2014},
  doi     = {10.1016/j.celrep.2014.09.042},
  pmid    = {25437566},
  url     = {https://doi.org/10.1016/j.celrep.2014.09.042}
}

@article{du2025-40320714,
  author  = {Du, Fang Ling and Yu, Qing and Hu, Gang and Lin, Chyuan‐Sheng and Yan, Shirley ShiDu},
  title   = {{PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer disease}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2463322},
  pmid    = {40320714},
  url     = {https://doi.org/10.1080/15548627.2025.2463322}
}

@article{bayram2026-41933395,
  author  = {Bayram, Ece and Carter, Danelle J. and Aslam, Sana and Forbes, Emily K. and Holden, Samantha K.},
  title   = {{Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies}},
  journal = {Biology of Sex Differences},
  year    = {2026},
  doi     = {10.1186/s13293-026-00899-5},
  pmid    = {41933395},
  url     = {https://doi.org/10.1186/s13293-026-00899-5}
}

@article{ali2025-40336141,
  author  = {Ali, Muhammad and Garcia, Pierre and Lunkes, Laetitia P. and Sciortino, Alessia and Thomas, Mélanie H. and Heurtaux, Tony and Grzyb, Kamil and Halder, Rashi and others},
  title   = {{Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02013-z},
  pmid    = {40336141},
  url     = {https://doi.org/10.1186/s40478-025-02013-z}
}

@article{ayyubova2026-41596124,
  author  = {Ayyubova, Gunel and Bablu, Fariha E and Rahimli, Nazrin and Aghayeva, Leyla and Springer, Elijah M. and Alghenaim, Fada A. and Suzuki, Yuichiro J.},
  title   = {{Roles of Reactive Oxygen Species in Relationships Between Viral Infections and Alzheimer’s Disease and Related Dementia}},
  journal = {Antioxidants},
  year    = {2026},
  doi     = {10.3390/antiox15010066},
  pmid    = {41596124},
  url     = {https://doi.org/10.3390/antiox15010066}
}

@article{guruacharya2026-42624102,
  author  = {Guruacharya, Anuj and Härtung, Thomas and Reis, Roberta Sena and Moreira, Natália Chermont dos Santos and Attisano, Liliana and Bolognin, Silvia and Iqbal, Khalid and Rajbanshi, Binita},
  title   = {{Brain organoids in Alzheimer disease and related tauopathies: Challenges and opportunities for translational readiness}},
  journal = {Stem Cell Reports},
  year    = {2026},
  doi     = {10.1016/j.stemcr.2026.103051},
  pmid    = {42624102},
  url     = {https://doi.org/10.1016/j.stemcr.2026.103051}
}

@article{carra2025-40398193,
  author  = {Carra, Serena and Fábián, Balázs and Taghavi, Hamed Vaez and Milanetti, Edoardo and Giliberti, Valeria and Ruocco, Giancarlo and Shepherd, Jason D. and Vendruscolo, Michele and others},
  title   = {{Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases}},
  journal = {Molecular Aspects of Medicine},
  year    = {2025},
  doi     = {10.1016/j.mam.2025.101369},
  pmid    = {40398193},
  url     = {https://doi.org/10.1016/j.mam.2025.101369}
}

@article{chen2025-40588144,
  author  = {Chen, Dongmei and Li, Ruomeng and She, Fei and Chen, Jiawen and Cho, Sang Min and Yang, Bohyun and Tian, Yuan and Guan, Le and others},
  title   = {{Saikosaponin C ameliorates tau-related pathology by modulating oxidative stress and MAPK axis in Alzheimer's disease}},
  journal = {Journal of Ethnopharmacology},
  year    = {2025},
  doi     = {10.1016/j.jep.2025.120221},
  pmid    = {40588144},
  url     = {https://doi.org/10.1016/j.jep.2025.120221}
}

@article{shami2026-40990233,
  author  = {Shami, R. and El Majzoub, R. and Ismail, A. and Kotaich, J. and Kassem, M. and Safadieh, G. and Fayyad-Kazan, M. and Chahine, B.},
  title   = {{Effects of triptolide herb on the progression of Alzheimer's disease preclinical models: a systematic review}},
  journal = {Neurodegenerative disease management},
  year    = {2026},
  doi     = {10.1080/17582024.2025.2562776},
  pmid    = {40990233},
  url     = {https://doi.org/10.1080/17582024.2025.2562776}
}

@article{aljarba2025-39892578,
  author  = {Aljarba, Nada Hamad and Al-Kuraishy, Hayder Mutter and Al-Gareeb, Ali Ismail and Shokr, Mustafa M and Papadakis, Marios and Alexiou, Athanasios T. and Alruwaili, Mubarak and Alrouji, Mohammed and others},
  title   = {{The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke}},
  journal = {Brain Research Bulletin},
  year    = {2025},
  doi     = {10.1016/j.brainresbull.2025.111236},
  pmid    = {39892578},
  url     = {https://doi.org/10.1016/j.brainresbull.2025.111236}
}

@article{ji2025-41249845,
  author  = {Ji, Jeff X. and Giles, Brian L. and Bhattacharjee, Surjyadipta and Kautzmann, Marie-Audrey Ines and Masson, Alasdair P. and Carmo, Sonia Do and Cuello, A. Claudio and Bazan, Nicolas Guillermo},
  title   = {{Intercellular signaling and synaptic deconstruction uncovered by single-cell and spatial transcriptomics in an AD tauopathy model}},
  journal = {Communications Biology},
  year    = {2025},
  doi     = {10.1038/s42003-025-08959-z},
  pmid    = {41249845},
  url     = {https://doi.org/10.1038/s42003-025-08959-z}
}

@article{watanabe2025-40677151,
  author  = {Watanabe, Ryohei and Papatriantafyllou, John D. and Maeda, Kengo and Aguirre, Geoffrey K. and Ando, Masahiro and Benoit, Bernice M. and Grossman, Murray and Irwin, David John and others},
  title   = {{Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70427},
  pmid    = {40677151},
  url     = {https://doi.org/10.1002/alz.70427}
}

@article{katsinelos2025-41260337,
  author  = {Katsinelos, Panagiotis and Lövestam, Sofia and Qi, Chao and Falcon, Benjamin and Macdonald, Jennifer A. and Stephenson, Gabriel and Ghetti, Bernardino Francesco and McKee, Ann Carolyn and others},
  title   = {{Seeding biosensor cell line that reproduces the Alzheimer tau fold}},
  journal = {Journal of Biological Chemistry},
  year    = {2025},
  doi     = {10.1016/j.jbc.2025.110952},
  pmid    = {41260337},
  url     = {https://doi.org/10.1016/j.jbc.2025.110952}
}

@article{johansson2025-41005266,
  author  = {Johansson, Charlotte and Koenig, Thomas W. and Smailović, Una and Hallström, Vanessa and Jelić, Vesna and Graff, Caroline},
  title   = {{Selective association of EEG microstates with clinical symptoms and mutation status in monogenic Alzheimer disease}},
  journal = {NeuroImage Clinical},
  year    = {2025},
  doi     = {10.1016/j.nicl.2025.103879},
  pmid    = {41005266},
  url     = {https://doi.org/10.1016/j.nicl.2025.103879}
}

@article{kuriyama2025-39939242,
  author  = {Kuriyama, Mai and Wang, Chu Fan and Nagase, Tatsuya and Sohma, Youhei and Kanai, Motomu and Hori, Yukiko and Tomita, Taisuke},
  title   = {{Proteolytic therapeutic modalities for amyloidoses: Insights into immunotherapy, PROTAC, and photo-oxygenation}},
  journal = {Neurotherapeutics},
  year    = {2025},
  doi     = {10.1016/j.neurot.2025.e00548},
  pmid    = {39939242},
  url     = {https://doi.org/10.1016/j.neurot.2025.e00548}
}

@article{zhu2025-39842821,
  author  = {Zhu, Sanyong and Song, Zhenfeng and Tapayan, April Sweet and Singh, Kartikey and Wang, Kuang‐Wei and Hagar, Hsiao‐Tien Chien and Zhang, Jicheng and Kim, Hyunbae and others},
  title   = {{Effects of Heparan Sulfate Trisaccharide Containing Oleanolic Acid in Attenuating Hyperphosphorylated Tau-Induced Cell Dysfunction Associated with Alzheimer’s Disease}},
  journal = {Journal of Medicinal Chemistry},
  year    = {2025},
  doi     = {10.1021/acs.jmedchem.4c02563},
  pmid    = {39842821},
  url     = {https://doi.org/10.1021/acs.jmedchem.4c02563}
}

@article{cokdinleyen2025-40430450,
  author  = {Cokdinleyen, Melis and Valdés, Alberto and Kara, Hüseyin and Ibáñez, Elena and Cifuentes, Alejandro},
  title   = {{Neuroprotective Potential of Tetraselmis chuii Compounds: Insights into Blood–Brain Barrier Permeability and Intestinal Transport}},
  journal = {Pharmaceuticals},
  year    = {2025},
  doi     = {10.3390/ph18050629},
  pmid    = {40430450},
  url     = {https://doi.org/10.3390/ph18050629}
}

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