% alzhub.org library filter
% Source: https://alzhub.org/research?category=inflammation&score_min=30&score_max=49
% 500 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{takeuchi2006-16720574,
  author  = {Takeuchi, H. and Jin, S. and Wang, J. and Zhang, G. and Kawanokuchi, J. and Kuno, R. and Sonobe, Y. and Mizuno, T. and others},
  title   = {{Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m600504200},
  pmid    = {16720574},
  url     = {https://doi.org/10.1074/jbc.m600504200}
}

@article{lee2010-20552234,
  author  = {Lee, C. Y. and Landreth, G. E.},
  title   = {{The role of microglia in amyloid clearance from the AD brain}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2010},
  doi     = {10.1007/s00702-010-0433-4},
  pmid    = {20552234},
  url     = {https://doi.org/10.1007/s00702-010-0433-4}
}

@article{kim2005-15954124,
  author  = {Kim, S. U. and de Vellis, J.},
  title   = {{Microglia in health and disease}},
  journal = {Journal of neuroscience research},
  year    = {2005},
  doi     = {10.1002/jnr.20562},
  pmid    = {15954124},
  url     = {https://doi.org/10.1002/jnr.20562}
}

@article{poole2013-23666172,
  author  = {Poole, S. and Singhrao, S. K. and Kesavalu, L. and Curtis, M. A. and Crean, S.},
  title   = {{Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-121918},
  pmid    = {23666172},
  url     = {https://doi.org/10.3233/jad-121918}
}

@article{mcgeer2007-16697488,
  author  = {McGeer, P. L. and McGeer, E. G.},
  title   = {{NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies}},
  journal = {Neurobiology of aging},
  year    = {2007},
  doi     = {10.1016/j.neurobiolaging.2006.03.013},
  pmid    = {16697488},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2006.03.013}
}

@article{town2005-16259628,
  author  = {Town, T. and Nikolic, V. and Tan, J.},
  title   = {{The microglial "activation" continuum: from innate to adaptive responses}},
  journal = {Journal of neuroinflammation},
  year    = {2005},
  doi     = {10.1186/1742-2094-2-24},
  pmid    = {16259628},
  url     = {https://doi.org/10.1186/1742-2094-2-24}
}

@article{shaftel2007-17549256,
  author  = {Shaftel, S. S. and Kyrkanides, S. and Olschowka, J. A. and Miller, J. N. and Johnson, R. E. and O'Banion, M. K.},
  title   = {{Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology}},
  journal = {The Journal of clinical investigation},
  year    = {2007},
  doi     = {10.1172/jci31450},
  pmid    = {17549256},
  url     = {https://doi.org/10.1172/jci31450}
}

@article{liu2002-12076984,
  author  = {Liu, B. and Gao, H. M. and Wang, J. Y. and Jeohn, G. H. and Cooper, C. L. and Hong, J. S.},
  title   = {{Role of nitric oxide in inflammation-mediated neurodegeneration}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2002},
  doi     = {10.1111/j.1749-6632.2002.tb04077.x},
  pmid    = {12076984},
  url     = {https://doi.org/10.1111/j.1749-6632.2002.tb04077.x}
}

@article{mcgeer1988-2974227,
  author  = {McGeer, P. L. and Itagaki, S. and McGeer, E. G.},
  title   = {{Expression of the histocompatibility glycoprotein HLA-DR in neurological disease}},
  journal = {Acta neuropathologica},
  year    = {1988},
  doi     = {10.1007/bf00689592},
  pmid    = {2974227},
  url     = {https://doi.org/10.1007/bf00689592}
}

@article{bagasra1996-8780811,
  author  = {Bagasra, O. and Lavi, E. and Bobroski, L. and Khalili, K. and Pestaner, J. P. and Tawadros, R. and Pomerantz, R. J.},
  title   = {{Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry}},
  journal = {AIDS (London, England)},
  year    = {1996},
  doi     = {10.1097/00002030-199606000-00002},
  pmid    = {8780811},
  url     = {https://doi.org/10.1097/00002030-199606000-00002}
}

@article{bae2012-23015436,
  author  = {Bae, E. J. and Lee, H. J. and Rockenstein, E. and Ho, D. H. and Park, E. B. and Yang, N. Y. and Desplats, P. and Masliah, E. and others},
  title   = {{Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.1292-12.2012},
  pmid    = {23015436},
  url     = {https://doi.org/10.1523/jneurosci.1292-12.2012}
}

@article{streit2014-25257319,
  author  = {Streit, W. J. and Xue, Q. S. and Tischer, J. and Bechmann, I.},
  title   = {{Microglial pathology}},
  journal = {Acta neuropathologica communications},
  year    = {2014},
  doi     = {10.1186/s40478-014-0142-6},
  pmid    = {25257319},
  url     = {https://doi.org/10.1186/s40478-014-0142-6}
}

@article{emery2017-28676754,
  author  = {Emery, D. C. and Shoemark, D. K. and Batstone, T. E. and Waterfall, C. M. and Coghill, J. A. and Cerajewska, T. L. and Davies, M. and West, N. X. and others},
  title   = {{16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer's Post-Mortem Brain}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00195},
  pmid    = {28676754},
  url     = {https://doi.org/10.3389/fnagi.2017.00195}
}

@article{lee2003-12655043,
  author  = {Lee, J. and Ryu, H. and Ferrante, R. J. and Morris, S. M. and Ratan, R. R.},
  title   = {{Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2003},
  doi     = {10.1073/pnas.0735876100},
  pmid    = {12655043},
  url     = {https://doi.org/10.1073/pnas.0735876100}
}

@article{bright2019-31324897,
  author  = {Bright, F. and Werry, E. L. and Dobson-Stone, C. and Piguet, O. and Ittner, L. M. and Halliday, G. M. and Hodges, JR. and Kiernan, M. C. and others},
  title   = {{Neuroinflammation in frontotemporal dementia}},
  journal = {Nature reviews. Neurology},
  year    = {2019},
  doi     = {10.1038/s41582-019-0231-z},
  pmid    = {31324897},
  url     = {https://doi.org/10.1038/s41582-019-0231-z}
}

@article{gaikwad2021-34289368,
  author  = {Gaikwad, S. and Puangmalai, N. and Bittar, A. and Montalbano, M. and Garcia, S. and McAllen, S. and Bhatt, N. and Sonawane, M. and others},
  title   = {{Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.109419},
  pmid    = {34289368},
  url     = {https://doi.org/10.1016/j.celrep.2021.109419}
}

@article{wang2017-28188218,
  author  = {Wang, M. and Ding, F. and Deng, S. and Guo, X. and Wang, W. and Iliff, J. J. and Nedergaard, M.},
  title   = {{Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2112-16.2017},
  pmid    = {28188218},
  url     = {https://doi.org/10.1523/jneurosci.2112-16.2017}
}

@article{nasb2024-37450931,
  author  = {Nasb, M. and Tao, W. and Chen, N.},
  title   = {{Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses}},
  journal = {Aging and disease},
  year    = {2024},
  doi     = {10.14336/ad.2023.0608},
  pmid    = {37450931},
  url     = {https://doi.org/10.14336/ad.2023.0608}
}

@article{yokoyama2022-35799899,
  author  = {Yokoyama, M. and Kobayashi, H. and Tatsumi, L. and Tomita, T.},
  title   = {{Mouse Models of Alzheimer's Disease}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2022},
  doi     = {10.3389/fnmol.2022.912995},
  pmid    = {35799899},
  url     = {https://doi.org/10.3389/fnmol.2022.912995}
}

@article{taipa2019-30711675,
  author  = {Taipa, R. and das Neves, S. P. and Sousa, A. L. and Fernandes, J. and Pinto, C. and Correia, A. P. and Santos, E. and Pinto, P. S. and others},
  title   = {{Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline}},
  journal = {Neurobiology of aging},
  year    = {2019},
  doi     = {10.1016/j.neurobiolaging.2018.12.019},
  pmid    = {30711675},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2018.12.019}
}

@article{morgantikossmann2019-30535946,
  author  = {Morganti-Kossmann, M. C. and Semple, B. D. and Hellewell, S. C. and Bye, N. and Ziebell, J. M.},
  title   = {{The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-018-1944-6},
  pmid    = {30535946},
  url     = {https://doi.org/10.1007/s00401-018-1944-6}
}

@article{novoa2022-36550479,
  author  = {Novoa, C. and Salazar, P. and Cisternas, P. and Gherardelli, C. and Vera-Salazar, R. and Zolezzi, J. M. and Inestrosa, N. C.},
  title   = {{Inflammation context in Alzheimer's disease, a relationship intricate to define}},
  journal = {Biological research},
  year    = {2022},
  doi     = {10.1186/s40659-022-00404-3},
  pmid    = {36550479},
  url     = {https://doi.org/10.1186/s40659-022-00404-3}
}

@article{chen2021-33680283,
  author  = {Chen, H. L. and Chen, P. C. and Lu, C. H. and Tsai, N. W. and Yu, C. C. and Chou, K. H. and Lai, Y. R. and Taoka, T. and others},
  title   = {{Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2021},
  doi     = {10.1155/2021/4034509},
  pmid    = {33680283},
  url     = {https://doi.org/10.1155/2021/4034509}
}

@article{saha2021-35126058,
  author  = {Saha, S. and Buttari, B. and Profumo, E. and Tucci, P. and Saso, L.},
  title   = {{A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2021},
  doi     = {10.3389/fncel.2021.787258},
  pmid    = {35126058},
  url     = {https://doi.org/10.3389/fncel.2021.787258}
}

@article{preman2021-33806259,
  author  = {Preman, P. and Alfonso-Triguero, M. and Alberdi, E. and Verkhratsky, A. and Arranz, A. M.},
  title   = {{Astrocytes in Alzheimer's Disease: Pathological Significance and Molecular Pathways}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10030540},
  pmid    = {33806259},
  url     = {https://doi.org/10.3390/cells10030540}
}

@article{kent2024-37452201,
  author  = {Kent, S. A. and Miron, V. E.},
  title   = {{Microglia regulation of central nervous system myelin health and regeneration}},
  journal = {Nature reviews. Immunology},
  year    = {2024},
  doi     = {10.1038/s41577-023-00907-4},
  pmid    = {37452201},
  url     = {https://doi.org/10.1038/s41577-023-00907-4}
}

@article{noh2025-40640892,
  author  = {Noh, Min‐Young and Kwon, Hyuk Sung and Kwon, Min‐Soo and Nahm, Minyeop and Jin, Hee Kyung and Bae, Jae‐sung and Kim, Seung Hyun},
  title   = {{Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00867-4},
  pmid    = {40640892},
  url     = {https://doi.org/10.1186/s13024-025-00867-4}
}

@article{kurz2025-40314736,
  author  = {Kurz, Carolin and De Carli, Laura and Gürsel, Selim Üstün and Schrurs, Isabelle and Jethwa, Alexander and Carboni, Margherita and Bittner, Tobias and Hortsch, Sayuri and others},
  title   = {{Plasma biomarkers of amyloid, tau \& neuroinflammation in Alzheimer’s disease and corticobasal syndrome}},
  journal = {European Archives of Psychiatry and Clinical Neuroscience},
  year    = {2025},
  doi     = {10.1007/s00406-025-02013-z},
  pmid    = {40314736},
  url     = {https://doi.org/10.1007/s00406-025-02013-z}
}

@article{sm2026-42736501,
  author  = {ȘM, Mocrei-Rebrean and Răzniceanu, V. and Pintilie, SR. and Berindan-Neagoe, I.},
  title   = {{Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review}},
  journal = {Molecular neurobiology},
  year    = {2026},
  doi     = {10.1007/s12035-026-06198-9},
  pmid    = {42736501},
  url     = {https://doi.org/10.1007/s12035-026-06198-9}
}

@article{motisibertulli2026-42172661,
  author  = {Motisi Bertulli, A. and Bezzio, C. and Marsano, S. and Corradini, I. and Stranges, S. and Matteoli, M. and Armuzzi, A.},
  title   = {{Does inflammatory bowel disease play a role in cognitive decline? A systematic review}},
  journal = {Journal of Crohn's \& colitis},
  year    = {2026},
  doi     = {10.1093/ecco-jcc/jjag057},
  pmid    = {42172661},
  url     = {https://doi.org/10.1093/ecco-jcc/jjag057}
}

@article{chowdhury2020-32178745,
  author  = {Chowdhury, A. and Rajkumar, A. P.},
  title   = {{Systematic review of gene expression studies in people with Lewy body dementia}},
  journal = {Acta neuropsychiatrica},
  year    = {2020},
  doi     = {10.1017/neu.2020.13},
  pmid    = {32178745},
  url     = {https://doi.org/10.1017/neu.2020.13}
}

@article{bouchon2000-10799849,
  author  = {Bouchon, Axel and Dietrich, Jes and Colonna, Marco},
  title   = {{Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes}},
  journal = {The Journal of Immunology},
  year    = {2000},
  doi     = {10.4049/jimmunol.164.10.4991},
  pmid    = {10799849},
  url     = {https://doi.org/10.4049/jimmunol.164.10.4991}
}

@article{chen2016-26935478,
  author  = {Chen, W. W. and Zhang, X. and Huang, W. J.},
  title   = {{Role of neuroinflammation in neurodegenerative diseases (Review)}},
  journal = {Molecular medicine reports},
  year    = {2016},
  doi     = {10.3892/mmr.2016.4948},
  pmid    = {26935478},
  url     = {https://doi.org/10.3892/mmr.2016.4948}
}

@article{gonzalezreyes2017-29311817,
  author  = {González-Reyes, R. E. and Nava-Mesa, M. O. and Vargas-Sánchez, K. and Ariza-Salamanca, D. and Mora-Muñoz, L.},
  title   = {{Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2017},
  doi     = {10.3389/fnmol.2017.00427},
  pmid    = {29311817},
  url     = {https://doi.org/10.3389/fnmol.2017.00427}
}

@article{walter2007-17982277,
  author  = {Walter, S. and Letiembre, M. and Liu, Y. and Heine, H. and Penke, B. and Hao, W. and Bode, B. and Manietta, N. and others},
  title   = {{Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease}},
  journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year    = {2007},
  doi     = {10.1159/000110455},
  pmid    = {17982277},
  url     = {https://doi.org/10.1159/000110455}
}

@article{tarantini2017-27845201,
  author  = {Tarantini, S. and Tran, C. H. T. and Gordon, G. R. and Ungvari, Z. and Csiszar, A.},
  title   = {{Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline}},
  journal = {Experimental gerontology},
  year    = {2017},
  doi     = {10.1016/j.exger.2016.11.004},
  pmid    = {27845201},
  url     = {https://doi.org/10.1016/j.exger.2016.11.004}
}

@article{skaper2018-29618972,
  author  = {Skaper, S. D. and Facci, L. and Zusso, M. and Giusti, P.},
  title   = {{An Inflammation-Centric View of Neurological Disease: Beyond the Neuron}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2018},
  doi     = {10.3389/fncel.2018.00072},
  pmid    = {29618972},
  url     = {https://doi.org/10.3389/fncel.2018.00072}
}

@article{cabezas2014-25136294,
  author  = {Cabezas, R. and Avila, M. and Gonzalez, J. and El-Bachá, R. S. and Báez, E. and García-Segura, L. M. and Jurado Coronel, J. C. and Capani, F. and others},
  title   = {{Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2014},
  doi     = {10.3389/fncel.2014.00211},
  pmid    = {25136294},
  url     = {https://doi.org/10.3389/fncel.2014.00211}
}

@article{lloyd2019-31256193,
  author  = {Lloyd, A. F. and Miron, V. E.},
  title   = {{The pro-remyelination properties of microglia in the central nervous system}},
  journal = {Nature reviews. Neurology},
  year    = {2019},
  doi     = {10.1038/s41582-019-0184-2},
  pmid    = {31256193},
  url     = {https://doi.org/10.1038/s41582-019-0184-2}
}

@article{he2017-28579942,
  author  = {He, X. F. and Liu, D. X. and Zhang, Q. and Liang, F. Y. and Dai, G. Y. and Zeng, J. S. and Pei, Z. and Xu, G. Q. and others},
  title   = {{Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2017},
  doi     = {10.3389/fnmol.2017.00144},
  pmid    = {28579942},
  url     = {https://doi.org/10.3389/fnmol.2017.00144}
}

@article{gu2010-20409326,
  author  = {Gu, X. L. and Long, C. X. and Sun, L. and Xie, C. and Lin, X. and Cai, H.},
  title   = {{Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice}},
  journal = {Molecular brain},
  year    = {2010},
  doi     = {10.1186/1756-6606-3-12},
  pmid    = {20409326},
  url     = {https://doi.org/10.1186/1756-6606-3-12}
}

@article{kirkley2017-28476157,
  author  = {Kirkley, K. S. and Popichak, K. A. and Afzali, M. F. and Legare, M. E. and Tjalkens, R. B.},
  title   = {{Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity}},
  journal = {Journal of neuroinflammation},
  year    = {2017},
  doi     = {10.1186/s12974-017-0871-0},
  pmid    = {28476157},
  url     = {https://doi.org/10.1186/s12974-017-0871-0}
}

@article{green2004-15255951,
  author  = {Green, P. S. and Mendez, A. J. and Jacob, J. S. and Crowley, JR. and Growdon, W. and Hyman, B. T. and Heinecke, J. W.},
  title   = {{Neuronal expression of myeloperoxidase is increased in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2004},
  doi     = {10.1111/j.1471-4159.2004.02527.x},
  pmid    = {15255951},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02527.x}
}

@article{jantzen2002-11896164,
  author  = {Jantzen, P. T. and Connor, K. E. and DiCarlo, G. and Wenk, G. L. and Wallace, J. L. and Rojiani, A. M. and Coppola, D. and Morgan, D. and others},
  title   = {{Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2002},
  doi     = {10.1523/jneurosci.22-06-02246.2002},
  pmid    = {11896164},
  url     = {https://doi.org/10.1523/jneurosci.22-06-02246.2002}
}

@article{kaushal2015-25744023,
  author  = {Kaushal, V. and Dye, R. and Pakavathkumar, P. and Foveau, B. and Flores, J. and Hyman, B. and Ghetti, B. and Koller, B. H. and others},
  title   = {{Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation}},
  journal = {Cell death and differentiation},
  year    = {2015},
  doi     = {10.1038/cdd.2015.16},
  pmid    = {25744023},
  url     = {https://doi.org/10.1038/cdd.2015.16}
}

@article{megur2020-33374235,
  author  = {Megur, A. and Baltriukienė, D. and Bukelskienė, V. and Burokas, A.},
  title   = {{The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?}},
  journal = {Nutrients},
  year    = {2020},
  doi     = {10.3390/nu13010037},
  pmid    = {33374235},
  url     = {https://doi.org/10.3390/nu13010037}
}

@article{paudel2020-32046119,
  author  = {Paudel, Y. N. and Angelopoulou, E. and Piperi, C. and Othman, I. and Aamir, K. and Shaikh, M. F.},
  title   = {{Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9020383},
  pmid    = {32046119},
  url     = {https://doi.org/10.3390/cells9020383}
}

@article{bagyinszky2017-28431620,
  author  = {Bagyinszky, E. and Giau, V. V. and Shim, K. and Suk, K. and An, S. S. A. and Kim, S.},
  title   = {{Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis}},
  journal = {Journal of the neurological sciences},
  year    = {2017},
  doi     = {10.1016/j.jns.2017.03.031},
  pmid    = {28431620},
  url     = {https://doi.org/10.1016/j.jns.2017.03.031}
}

@article{carnevale2012-22615109,
  author  = {Carnevale, D. and Mascio, G. and D'Andrea, I. and Fardella, V. and Bell, R. D. and Branchi, I. and Pallante, F. and Zlokovic, B. and others},
  title   = {{Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature}},
  journal = {Hypertension (Dallas, Tex. : 1979)},
  year    = {2012},
  doi     = {10.1161/hypertensionaha.112.195511},
  pmid    = {22615109},
  url     = {https://doi.org/10.1161/hypertensionaha.112.195511}
}

@article{mcmanus2017-28259169,
  author  = {McManus, R. M. and Heneka, M. T.},
  title   = {{Role of neuroinflammation in neurodegeneration: new insights}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0241-2},
  pmid    = {28259169},
  url     = {https://doi.org/10.1186/s13195-017-0241-2}
}

@article{hase2018-29210074,
  author  = {Hase, Y. and Horsburgh, K. and Ihara, M. and Kalaria, R. N.},
  title   = {{White matter degeneration in vascular and other ageing-related dementias}},
  journal = {Journal of neurochemistry},
  year    = {2018},
  doi     = {10.1111/jnc.14271},
  pmid    = {29210074},
  url     = {https://doi.org/10.1111/jnc.14271}
}

@article{mandler2014-24525765,
  author  = {Mandler, M. and Valera, E. and Rockenstein, E. and Weninger, H. and Patrick, C. and Adame, A. and Santic, R. and Meindl, S. and others},
  title   = {{Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials}},
  journal = {Acta neuropathologica},
  year    = {2014},
  doi     = {10.1007/s00401-014-1256-4},
  pmid    = {24525765},
  url     = {https://doi.org/10.1007/s00401-014-1256-4}
}

@article{neniskyte2011-21903584,
  author  = {Neniskyte, U. and Neher, J. J. and Brown, G. C.},
  title   = {{Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m111.267583},
  pmid    = {21903584},
  url     = {https://doi.org/10.1074/jbc.m111.267583}
}

@article{connell2022-35715821,
  author  = {Connell, E. and Le Gall, G. and Pontifex, M. G. and Sami, S. and Cryan, J. F. and Clarke, G. and Müller, M. and Vauzour, D.},
  title   = {{Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00548-6},
  pmid    = {35715821},
  url     = {https://doi.org/10.1186/s13024-022-00548-6}
}

@article{fan2015-25239737,
  author  = {Fan, Z. and Aman, Y. and Ahmed, I. and Chetelat, G. and Landeau, B. and Ray Chaudhuri, K. and Brooks, D. J. and Edison, P.},
  title   = {{Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.06.016},
  pmid    = {25239737},
  url     = {https://doi.org/10.1016/j.jalz.2014.06.016}
}

@article{ballard2020-32939050,
  author  = {Ballard, C. and Aarsland, D. and Cummings, J. and O'Brien, J. and Mills, R. and Molinuevo, J. L. and Fladby, T. and Williams, G. and others},
  title   = {{Drug repositioning and repurposing for Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2020},
  doi     = {10.1038/s41582-020-0397-4},
  pmid    = {32939050},
  url     = {https://doi.org/10.1038/s41582-020-0397-4}
}

@article{kenkhuis2021-33597025,
  author  = {Kenkhuis, B. and Somarakis, A. and de Haan, L. and Dzyubachyk, O. and IJsselsteijn, M. E. and de Miranda, N. F. C. C. and Lelieveldt, B. P. F. and Dijkstra, J. and others},
  title   = {{Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients}},
  journal = {Acta neuropathologica communications},
  year    = {2021},
  doi     = {10.1186/s40478-021-01126-5},
  pmid    = {33597025},
  url     = {https://doi.org/10.1186/s40478-021-01126-5}
}

@article{cagnin2004-15562429,
  author  = {Cagnin, A. and Rossor, M. and Sampson, E. L. and Mackinnon, T. and Banati, R. B.},
  title   = {{In vivo detection of microglial activation in frontotemporal dementia}},
  journal = {Annals of neurology},
  year    = {2004},
  doi     = {10.1002/ana.20332},
  pmid    = {15562429},
  url     = {https://doi.org/10.1002/ana.20332}
}

@article{shahidehpour2021-33422891,
  author  = {Shahidehpour, R. K. and Higdon, R. E. and Crawford, N. G. and Neltner, J. H. and Ighodaro, E. T. and Patel, E. and Price, D. and Nelson, P. T. and others},
  title   = {{Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2020.12.003},
  pmid    = {33422891},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2020.12.003}
}

@article{xiao2025-40581647,
  author  = {Xiao, Weiping and Yang, Yibing and Lu, Bai and Yang, Peixuan and Li, Runze and Yang, Daizhi and Li, Fanying and Quan, Lingzhi and others},
  title   = {{Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03493-5},
  pmid    = {40581647},
  url     = {https://doi.org/10.1186/s12974-025-03493-5}
}

@article{su2025-40595567,
  author  = {Su, Yixun and Li, Hui and Zhang, Wenjie and Tao, Shi and Wang, Qi and Zhang, Xuan and Zhou, Mi and Huang, Xiaomin and others},
  title   = {{Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis}},
  journal = {Nature Communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-60746-w},
  pmid    = {40595567},
  url     = {https://doi.org/10.1038/s41467-025-60746-w}
}

@article{ma2025-40350295,
  author  = {Ma, Yanan and Karako, Kenji and Song, Peipei and Xia, Ying},
  title   = {{Can the herpes zoster vaccination be a strategy against dementia?}},
  journal = {Drug Discoveries \& Therapeutics},
  year    = {2025},
  doi     = {10.5582/ddt.2025.01032},
  pmid    = {40350295},
  url     = {https://doi.org/10.5582/ddt.2025.01032}
}

@article{qu2026-41907844,
  author  = {Qu, G. and Bi, Y. and Wang, L. and Xu, L. and Zhang, Y. and Ma, Y. and Tian, C. and Zhang, Z.},
  title   = {{Efficacy of Dang Gui Shao Yao San in treating vascular dementia in animal models: a systematic review and meta-analysis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2026},
  doi     = {10.3389/fnagi.2026.1701536},
  pmid    = {41907844},
  url     = {https://doi.org/10.3389/fnagi.2026.1701536}
}

@article{liu2025-39675515,
  author  = {Liu, C. and Chen, X. and Yang, S. and Wang, X. and Sun, P. and Wang, J. and Zhu, G.},
  title   = {{Insight into cerebral microvessel endothelial regulation of cognitive impairment: A systematic review of the causes and consequences}},
  journal = {Experimental neurology},
  year    = {2025},
  doi     = {10.1016/j.expneurol.2024.115116},
  pmid    = {39675515},
  url     = {https://doi.org/10.1016/j.expneurol.2024.115116}
}

@article{ouyang2026-42150695,
  author  = {Ouyang, Xiaoxue and Chia, Rachel S L and Chai, Yuek Ling and Chong, Joyce R and Sim, Ming Ann and Jo, Dong-Gyu and Arumugam, Thiruma V and Sethi, Gautam and others},
  title   = {{Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia}},
  journal = {Biochemical pharmacology},
  year    = {2026},
  doi     = {10.1016/j.bcp.2026.118077},
  pmid    = {42150695},
  url     = {https://doi.org/10.1016/j.bcp.2026.118077}
}

@article{gaire2026-41571675,
  author  = {Gaire, Bhakta Prasad and Koronyo, Yosef and Vit, Jean-Philippe and Hutton, Alexandre and Subedi, Lalita and Fuchs, Dieu-Trang and Swerdlow, Natalie and Rentsendorj, Altan and others},
  title   = {{Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68580-4},
  pmid    = {41571675},
  url     = {https://doi.org/10.1038/s41467-026-68580-4}
}

@article{lee2026-41789727,
  author  = {Lee, Jeongmi and Cho, Yongeun and Choi, Bo Youn and Kim, Hark Kyun and Lee, Yeongyeong and Kim, Eunae and Han, Jihoon and Sul, Jae Hoon and others},
  title   = {{HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag089},
  pmid    = {41789727},
  url     = {https://doi.org/10.1093/brain/awag089}
}

@article{shen2026-42489128,
  author  = {Shen, Qi and Chang, Haocai and Li, Junyu and Guo, Haoyun and Shi, Wenbin and Yan, Yihua and Ouyang, Wenwen and Zhang, Zhan and others},
  title   = {{Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag247},
  pmid    = {42489128},
  url     = {https://doi.org/10.1093/brain/awag247}
}

@article{dheen2007-17504139,
  author  = {Dheen, S. T. and Kaur, C. and Ling, E. A.},
  title   = {{Microglial activation and its implications in the brain diseases}},
  journal = {Current medicinal chemistry},
  year    = {2007},
  doi     = {10.2174/092986707780597961},
  pmid    = {17504139},
  url     = {https://doi.org/10.2174/092986707780597961}
}

@article{karve2016-25752446,
  author  = {Karve, I. P. and Taylor, J. M. and Crack, P. J.},
  title   = {{The contribution of astrocytes and microglia to traumatic brain injury}},
  journal = {British journal of pharmacology},
  year    = {2016},
  doi     = {10.1111/bph.13125},
  pmid    = {25752446},
  url     = {https://doi.org/10.1111/bph.13125}
}

@article{yuyama2012-22303002,
  author  = {Yuyama, K. and Sun, H. and Mitsutake, S. and Igarashi, Y.},
  title   = {{Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m111.324616},
  pmid    = {22303002},
  url     = {https://doi.org/10.1074/jbc.m111.324616}
}

@article{minter2016-26509334,
  author  = {Minter, M. R. and Taylor, J. M. and Crack, P. J.},
  title   = {{The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2016},
  doi     = {10.1111/jnc.13411},
  pmid    = {26509334},
  url     = {https://doi.org/10.1111/jnc.13411}
}

@article{eugenin2006-16436595,
  author  = {Eugenin, E. A. and Osiecki, K. and Lopez, L. and Goldstein, H. and Calderon, T. M. and Berman, J. W.},
  title   = {{CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.3863-05.2006},
  pmid    = {16436595},
  url     = {https://doi.org/10.1523/jneurosci.3863-05.2006}
}

@article{deane2004-15459432,
  author  = {Deane, R. and Wu, Z. and Zlokovic, B. V.},
  title   = {{RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier}},
  journal = {Stroke},
  year    = {2004},
  doi     = {10.1161/01.str.0000143452.85382.d1},
  pmid    = {15459432},
  url     = {https://doi.org/10.1161/01.str.0000143452.85382.d1}
}

@article{spagnuolo2018-28923363,
  author  = {Spagnuolo, C. and Moccia, S. and Russo, G. L.},
  title   = {{Anti-inflammatory effects of flavonoids in neurodegenerative disorders}},
  journal = {European journal of medicinal chemistry},
  year    = {2018},
  doi     = {10.1016/j.ejmech.2017.09.001},
  pmid    = {28923363},
  url     = {https://doi.org/10.1016/j.ejmech.2017.09.001}
}

@article{yuyama2014-25037226,
  author  = {Yuyama, K. and Sun, H. and Sakai, S. and Mitsutake, S. and Okada, M. and Tahara, H. and Furukawa, J. and Fujitani, N. and others},
  title   = {{Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m114.577213},
  pmid    = {25037226},
  url     = {https://doi.org/10.1074/jbc.m114.577213}
}

@article{churchill2009-19743454,
  author  = {Churchill, M. J. and Wesselingh, S. L. and Cowley, D. and Pardo, C. A. and McArthur, J. C. and Brew, B. J. and Gorry, P. R.},
  title   = {{Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia}},
  journal = {Annals of neurology},
  year    = {2009},
  doi     = {10.1002/ana.21697},
  pmid    = {19743454},
  url     = {https://doi.org/10.1002/ana.21697}
}

@article{dumont2011-21130159,
  author  = {Dumont, M. and Beal, M. F.},
  title   = {{Neuroprotective strategies involving ROS in Alzheimer disease}},
  journal = {Free radical biology \& medicine},
  year    = {2011},
  doi     = {10.1016/j.freeradbiomed.2010.11.026},
  pmid    = {21130159},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2010.11.026}
}

@article{fine1996-8663435,
  author  = {Fine, S. M. and Angel, R. A. and Perry, S. W. and Epstein, L. G. and Rothstein, J. D. and Dewhurst, S. and Gelbard, H. A.},
  title   = {{Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia}},
  journal = {The Journal of biological chemistry},
  year    = {1996},
  doi     = {10.1074/jbc.271.26.15303},
  pmid    = {8663435},
  url     = {https://doi.org/10.1074/jbc.271.26.15303}
}

@article{fonseca2009-19561098,
  author  = {Fonseca, M. I. and Ager, R. R. and Chu, S. H. and Yazan, O. and Sanderson, S. D. and LaFerla, F. M. and Taylor, S. M. and Woodruff, T. M. and others},
  title   = {{Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2009},
  doi     = {10.4049/jimmunol.0901005},
  pmid    = {19561098},
  url     = {https://doi.org/10.4049/jimmunol.0901005}
}

@article{heusinkveld2016-27448464,
  author  = {Heusinkveld, H. J. and Wahle, T. and Campbell, A. and Westerink, R. H. S. and Tran, L. and Johnston, H. and Stone, V. and Cassee, F. R. and others},
  title   = {{Neurodegenerative and neurological disorders by small inhaled particles}},
  journal = {Neurotoxicology},
  year    = {2016},
  doi     = {10.1016/j.neuro.2016.07.007},
  pmid    = {27448464},
  url     = {https://doi.org/10.1016/j.neuro.2016.07.007}
}

@article{mcdonald1997-9065490,
  author  = {McDonald, D. R. and Brunden, K. R. and Landreth, G. E.},
  title   = {{Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1997},
  doi     = {10.1523/jneurosci.17-07-02284.1997},
  pmid    = {9065490},
  url     = {https://doi.org/10.1523/jneurosci.17-07-02284.1997}
}

@article{testa2016-27687218,
  author  = {Testa, G. and Staurenghi, E. and Zerbinati, C. and Gargiulo, S. and Iuliano, L. and Giaccone, G. and Fantò, F. and Poli, G. and others},
  title   = {{Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation}},
  journal = {Redox biology},
  year    = {2016},
  doi     = {10.1016/j.redox.2016.09.001},
  pmid    = {27687218},
  url     = {https://doi.org/10.1016/j.redox.2016.09.001}
}

@article{chen2012-23122958,
  author  = {Chen, R. and Zhang, J. and Wu, Y. and Wang, D. and Feng, G. and Tang, Y. P. and Teng, Z. and Chen, C.},
  title   = {{Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease}},
  journal = {Cell reports},
  year    = {2012},
  doi     = {10.1016/j.celrep.2012.09.030},
  pmid    = {23122958},
  url     = {https://doi.org/10.1016/j.celrep.2012.09.030}
}

@article{michaud2013-23322736,
  author  = {Michaud, J. P. and Hallé, M. and Lampron, A. and Thériault, P. and Préfontaine, P. and Filali, M. and Tribout-Jover, P. and Lanteigne, A. M. and others},
  title   = {{Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2013},
  doi     = {10.1073/pnas.1215165110},
  pmid    = {23322736},
  url     = {https://doi.org/10.1073/pnas.1215165110}
}

@article{head2016-26651341,
  author  = {Head, E. and Lott, I. T. and Wilcock, D. M. and Lemere, C. A.},
  title   = {{Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology}},
  journal = {Current Alzheimer research},
  year    = {2016},
  doi     = {10.2174/1567205012666151020114607},
  pmid    = {26651341},
  url     = {https://doi.org/10.2174/1567205012666151020114607}
}

@article{michailidou2015-25727254,
  author  = {Michailidou, I. and Willems, J. G. and Kooi, E. J. and van Eden, C. and Gold, S. M. and Geurts, J. J. and Baas, F. and Huitinga, I. and others},
  title   = {{Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24398},
  pmid    = {25727254},
  url     = {https://doi.org/10.1002/ana.24398}
}

@article{bronzuoli2016-27843334,
  author  = {Bronzuoli, M. R. and Iacomino, A. and Steardo, L. and Scuderi, C.},
  title   = {{Targeting neuroinflammation in Alzheimer's disease}},
  journal = {Journal of inflammation research},
  year    = {2016},
  doi     = {10.2147/jir.s86958},
  pmid    = {27843334},
  url     = {https://doi.org/10.2147/jir.s86958}
}

@article{bauerl2018-29575030,
  author  = {Bäuerl, C. and Collado, M. C. and Diaz Cuevas, A. and Viña, J. and Pérez Martínez, G.},
  title   = {{Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan}},
  journal = {Letters in applied microbiology},
  year    = {2018},
  doi     = {10.1111/lam.12882},
  pmid    = {29575030},
  url     = {https://doi.org/10.1111/lam.12882}
}

@article{nichol2008-18400101,
  author  = {Nichol, K. E. and Poon, W. W. and Parachikova, A. I. and Cribbs, D. H. and Glabe, C. G. and Cotman, C. W.},
  title   = {{Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-13},
  pmid    = {18400101},
  url     = {https://doi.org/10.1186/1742-2094-5-13}
}

@article{munch1998-9720973,
  author  = {Münch, G. and Schinzel, R. and Loske, C. and Wong, A. and Durany, N. and Li, J. J. and Vlassara, H. and Smith, M. A. and others},
  title   = {{Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {1998},
  doi     = {10.1007/s007020050069},
  pmid    = {9720973},
  url     = {https://doi.org/10.1007/s007020050069}
}

@article{giulian1996-8815885,
  author  = {Giulian, D. and Haverkamp, L. J. and Yu, J. H. and Karshin, W. and Tom, D. and Li, J. and Kirkpatrick, J. and Kuo, L. M. and others},
  title   = {{Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1996},
  doi     = {10.1523/jneurosci.16-19-06021.1996},
  pmid    = {8815885},
  url     = {https://doi.org/10.1523/jneurosci.16-19-06021.1996}
}

@article{corcia2012-23300829,
  author  = {Corcia, P. and Tauber, C. and Vercoullie, J. and Arlicot, N. and Prunier, C. and Praline, J. and Nicolas, G. and Venel, Y. and others},
  title   = {{Molecular imaging of microglial activation in amyotrophic lateral sclerosis}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0052941},
  pmid    = {23300829},
  url     = {https://doi.org/10.1371/journal.pone.0052941}
}

@article{lewis2010-20847045,
  author  = {Lewis, T. L. and Cao, D. and Lu, H. and Mans, R. A. and Su, Y. R. and Jungbauer, L. and Linton, M. F. and Fazio, S. and others},
  title   = {{Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.127829},
  pmid    = {20847045},
  url     = {https://doi.org/10.1074/jbc.m110.127829}
}

@article{roumier2004-15601948,
  author  = {Roumier, A. and Béchade, C. and Poncer, J. C. and Smalla, K. H. and Tomasello, E. and Vivier, E. and Gundelfinger, E. D. and Triller, A. and others},
  title   = {{Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2004},
  doi     = {10.1523/jneurosci.2251-04.2004},
  pmid    = {15601948},
  url     = {https://doi.org/10.1523/jneurosci.2251-04.2004}
}

@article{chen2006-16339765,
  author  = {Chen, K. and Iribarren, P. and Hu, J. and Chen, J. and Gong, W. and Cho, E. H. and Lockett, S. and Dunlop, N. M. and others},
  title   = {{Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m508125200},
  pmid    = {16339765},
  url     = {https://doi.org/10.1074/jbc.m508125200}
}

@article{paloneva2001-11402114,
  author  = {Paloneva, J. and Autti, T. and Raininko, R. and Partanen, J. and Salonen, O. and Puranen, M. and Hakola, P. and Haltia, M.},
  title   = {{CNS manifestations of Nasu-Hakola disease: a frontal dementia with bone cysts}},
  journal = {Neurology},
  year    = {2001},
  doi     = {10.1212/wnl.56.11.1552},
  pmid    = {11402114},
  url     = {https://doi.org/10.1212/wnl.56.11.1552}
}

@article{grieco2019-31680842,
  author  = {Grieco, M. and Giorgi, A. and Gentile, M. C. and d'Erme, M. and Morano, S. and Maras, B. and Filardi, T.},
  title   = {{Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.01112},
  pmid    = {31680842},
  url     = {https://doi.org/10.3389/fnins.2019.01112}
}

@article{delaguila2019-31399126,
  author  = {Del-Aguila, J. L. and Li, Z. and Dube, U. and Mihindukulasuriya, K. A. and Budde, J. P. and Fernandez, M. V. and Ibanez, L. and Bradley, J. and others},
  title   = {{A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain}},
  journal = {Alzheimer's research \& therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0524-x},
  pmid    = {31399126},
  url     = {https://doi.org/10.1186/s13195-019-0524-x}
}

@article{grande2020-32171784,
  author  = {Grande, G. and Qiu, C. and Fratiglioni, L.},
  title   = {{Prevention of dementia in an ageing world: Evidence and biological rationale}},
  journal = {Ageing research reviews},
  year    = {2020},
  doi     = {10.1016/j.arr.2020.101045},
  pmid    = {32171784},
  url     = {https://doi.org/10.1016/j.arr.2020.101045}
}

@article{wang2012-23238711,
  author  = {Wang, M. and Iliff, J. J. and Liao, Y. and Chen, M. J. and Shinseki, M. S. and Venkataraman, A. and Cheung, J. and Wang, W. and others},
  title   = {{Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.1860-12.2012},
  pmid    = {23238711},
  url     = {https://doi.org/10.1523/jneurosci.1860-12.2012}
}

@article{dibenedetto2022-36078138,
  author  = {Di Benedetto, G. and Burgaletto, C. and Bellanca, C. M. and Munafò, A. and Bernardini, R. and Cantarella, G.},
  title   = {{Role of Microglia and Astrocytes in Alzheimer's Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11172728},
  pmid    = {36078138},
  url     = {https://doi.org/10.3390/cells11172728}
}

@article{shal2018-29896105,
  author  = {Shal, B. and Ding, W. and Ali, H. and Kim, Y. S. and Khan, S.},
  title   = {{Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease}},
  journal = {Frontiers in pharmacology},
  year    = {2018},
  doi     = {10.3389/fphar.2018.00548},
  pmid    = {29896105},
  url     = {https://doi.org/10.3389/fphar.2018.00548}
}

@article{lall2017-28737506,
  author  = {Lall, D. and Baloh, R. H.},
  title   = {{Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia}},
  journal = {The Journal of clinical investigation},
  year    = {2017},
  doi     = {10.1172/jci90607},
  pmid    = {28737506},
  url     = {https://doi.org/10.1172/jci90607}
}

@article{farkas2004-15138777,
  author  = {Farkas, E. and Donka, G. and de Vos, R. A. and Mihály, A. and Bari, F. and Luiten, P. G.},
  title   = {{Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain}},
  journal = {Acta neuropathologica},
  year    = {2004},
  doi     = {10.1007/s00401-004-0864-9},
  pmid    = {15138777},
  url     = {https://doi.org/10.1007/s00401-004-0864-9}
}

@article{grimaldi2019-31551688,
  author  = {Grimaldi, A. and Pediconi, N. and Oieni, F. and Pizzarelli, R. and Rosito, M. and Giubettini, M. and Santini, T. and Limatola, C. and others},
  title   = {{Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.00925},
  pmid    = {31551688},
  url     = {https://doi.org/10.3389/fnins.2019.00925}
}

@article{lenoel2025-40858618,
  author  = {Lenoël, Isadora and Ribon, Matthieu and Lorenc, Félicie and Diebold, Aurélien and Philibert, Clémentine Eva and Robaldo, David and Badsi, Manel and Perronnet, Julianne and others},
  title   = {{ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice}},
  journal = {Nature Communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-63211-w},
  pmid    = {40858618},
  url     = {https://doi.org/10.1038/s41467-025-63211-w}
}

@article{sun2025-40177166,
  author  = {Sun, Y. and Liu, Z. and Zhang, Z. and Kang, Y. and Wang, X. and Zhang, Y. and Liu, Y. and Zhao, P.},
  title   = {{Human induced pluripotent stem cell models for Alzheimer's disease research: a bibliometric analysis}},
  journal = {Frontiers in human neuroscience},
  year    = {2025},
  doi     = {10.3389/fnhum.2025.1548701},
  pmid    = {40177166},
  url     = {https://doi.org/10.3389/fnhum.2025.1548701}
}

@article{yokokura2011-20844871,
  author  = {Yokokura, M. and Mori, N. and Yagi, S. and Yoshikawa, E. and Kikuchi, M. and Yoshihara, Y. and Wakuda, T. and Sugihara, G. and others},
  title   = {{In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2011},
  doi     = {10.1007/s00259-010-1612-0},
  pmid    = {20844871},
  url     = {https://doi.org/10.1007/s00259-010-1612-0}
}

@article{bath2015-25727737,
  author  = {Bath, P. M. and Wardlaw, J. M.},
  title   = {{Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions}},
  journal = {International journal of stroke : official journal of the International Stroke Society},
  year    = {2015},
  doi     = {10.1111/ijs.12466},
  pmid    = {25727737},
  url     = {https://doi.org/10.1111/ijs.12466}
}

@article{navia1986-3014994,
  author  = {Navia, B. A. and Cho, E. S. and Petito, C. K. and Price, R. W.},
  title   = {{The AIDS dementia complex: II. Neuropathology}},
  journal = {Annals of neurology},
  year    = {1986},
  doi     = {10.1002/ana.410190603},
  pmid    = {3014994},
  url     = {https://doi.org/10.1002/ana.410190603}
}

@article{wendeln2018-29643512,
  author  = {Wendeln, A. C. and Degenhardt, K. and Kaurani, L. and Gertig, M. and Ulas, T. and Jain, G. and Wagner, J. and Häsler, L. M. and others},
  title   = {{Innate immune memory in the brain shapes neurological disease hallmarks}},
  journal = {Nature},
  year    = {2018},
  doi     = {10.1038/s41586-018-0023-4},
  pmid    = {29643512},
  url     = {https://doi.org/10.1038/s41586-018-0023-4}
}

@article{felipo2002-12207972,
  author  = {Felipo, V. and Butterworth, R. F.},
  title   = {{Neurobiology of ammonia}},
  journal = {Progress in neurobiology},
  year    = {2002},
  doi     = {10.1016/s0301-0082(02)00019-9},
  pmid    = {12207972},
  url     = {https://doi.org/10.1016/s0301-0082(02)00019-9}
}

@article{guillemin2001-11520905,
  author  = {Guillemin, G. J. and Kerr, S. J. and Smythe, G. A. and Smith, D. G. and Kapoor, V. and Armati, P. J. and Croitoru, J. and Brew, B. J.},
  title   = {{Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection}},
  journal = {Journal of neurochemistry},
  year    = {2001},
  doi     = {10.1046/j.1471-4159.2001.00498.x},
  pmid    = {11520905},
  url     = {https://doi.org/10.1046/j.1471-4159.2001.00498.x}
}

@article{cartier2005-15708626,
  author  = {Cartier, L. and Hartley, O. and Dubois-Dauphin, M. and Krause, K. H.},
  title   = {{Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases}},
  journal = {Brain research. Brain research reviews},
  year    = {2005},
  doi     = {10.1016/j.brainresrev.2004.07.021},
  pmid    = {15708626},
  url     = {https://doi.org/10.1016/j.brainresrev.2004.07.021}
}

@article{cho2014-25126727,
  author  = {Cho, M. H. and Cho, K. and Kang, H. J. and Jeon, E. Y. and Kim, H. S. and Kwon, H. J. and Kim, H. M. and Kim, D. H. and others},
  title   = {{Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome}},
  journal = {Autophagy},
  year    = {2014},
  doi     = {10.4161/auto.29647},
  pmid    = {25126727},
  url     = {https://doi.org/10.4161/auto.29647}
}

@article{quintanilla2004-15051507,
  author  = {Quintanilla, R. A. and Orellana, D. I. and González-Billault, C. and Maccioni, R. B.},
  title   = {{Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway}},
  journal = {Experimental cell research},
  year    = {2004},
  doi     = {10.1016/j.yexcr.2004.01.002},
  pmid    = {15051507},
  url     = {https://doi.org/10.1016/j.yexcr.2004.01.002}
}

@article{cui2018-28970251,
  author  = {Cui, G. H. and Wu, J. and Mou, F. F. and Xie, W. H. and Wang, F. B. and Wang, Q. L. and Fang, J. and Xu, Y. W. and others},
  title   = {{Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2018},
  doi     = {10.1096/fj.201700600r},
  pmid    = {28970251},
  url     = {https://doi.org/10.1096/fj.201700600r}
}

@article{munoz2010-19951717,
  author  = {Munoz, L. and Ammit, A. J.},
  title   = {{Targeting p38 MAPK pathway for the treatment of Alzheimer's disease}},
  journal = {Neuropharmacology},
  year    = {2010},
  doi     = {10.1016/j.neuropharm.2009.11.010},
  pmid    = {19951717},
  url     = {https://doi.org/10.1016/j.neuropharm.2009.11.010}
}

@article{eikelenboom2002-12379910,
  author  = {Eikelenboom, P. and Bate, C. and Van Gool, W. A. and Hoozemans, J. J. M. and Rozemuller, J. M. and Veerhuis, R. and Williams, A.},
  title   = {{Neuroinflammation in Alzheimer's disease and prion disease}},
  journal = {Glia},
  year    = {2002},
  doi     = {10.1002/glia.10146},
  pmid    = {12379910},
  url     = {https://doi.org/10.1002/glia.10146}
}

@article{mrak1995-7635444,
  author  = {Mrak, R. E. and Sheng, J. G. and Griffin, W. S.},
  title   = {{Glial cytokines in Alzheimer's disease: review and pathogenic implications}},
  journal = {Human pathology},
  year    = {1995},
  doi     = {10.1016/0046-8177(95)90001-2},
  pmid    = {7635444},
  url     = {https://doi.org/10.1016/0046-8177(95)90001-2}
}

@article{catorce2016-26639457,
  author  = {Catorce, M. N. and Gevorkian, G.},
  title   = {{LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals}},
  journal = {Current neuropharmacology},
  year    = {2016},
  doi     = {10.2174/1570159x14666151204122017},
  pmid    = {26639457},
  url     = {https://doi.org/10.2174/1570159x14666151204122017}
}

@article{cai2018-29782323,
  author  = {Cai, Z. and Qiao, P. F. and Wan, C. Q. and Cai, M. and Zhou, N. K. and Li, Q.},
  title   = {{Role of Blood-Brain Barrier in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-180098},
  pmid    = {29782323},
  url     = {https://doi.org/10.3233/jad-180098}
}

@article{abdul2009-19828810,
  author  = {Abdul, H. M. and Sama, M. A. and Furman, J. L. and Mathis, D. M. and Beckett, T. L. and Weidner, A. M. and Patel, E. S. and Baig, I. and others},
  title   = {{Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.1064-09.2009},
  pmid    = {19828810},
  url     = {https://doi.org/10.1523/jneurosci.1064-09.2009}
}

@article{masliah1992-1416802,
  author  = {Masliah, E. and Achim, C. L. and Ge, N. and DeTeresa, R. and Terry, R. D. and Wiley, C. A.},
  title   = {{Spectrum of human immunodeficiency virus-associated neocortical damage}},
  journal = {Annals of neurology},
  year    = {1992},
  doi     = {10.1002/ana.410320304},
  pmid    = {1416802},
  url     = {https://doi.org/10.1002/ana.410320304}
}

@article{mcgeer2010-20061650,
  author  = {McGeer, E. G. and McGeer, P. L.},
  title   = {{Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2010},
  doi     = {10.3233/jad-2010-1219},
  pmid    = {20061650},
  url     = {https://doi.org/10.3233/jad-2010-1219}
}

@article{egea2015-26232730,
  author  = {Egea, J. and Buendia, I. and Parada, E. and Navarro, E. and León, R. and Lopez, M. G.},
  title   = {{Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection}},
  journal = {Biochemical pharmacology},
  year    = {2015},
  doi     = {10.1016/j.bcp.2015.07.032},
  pmid    = {26232730},
  url     = {https://doi.org/10.1016/j.bcp.2015.07.032}
}

@article{streit2004-15197750,
  author  = {Streit, W. J.},
  title   = {{Microglia and Alzheimer's disease pathogenesis}},
  journal = {Journal of neuroscience research},
  year    = {2004},
  doi     = {10.1002/jnr.20093},
  pmid    = {15197750},
  url     = {https://doi.org/10.1002/jnr.20093}
}

@article{malm2005-15649704,
  author  = {Malm, T. M. and Koistinaho, M. and Pärepalo, M. and Vatanen, T. and Ooka, A. and Karlsson, S. and Koistinaho, J.},
  title   = {{Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2004.09.009},
  pmid    = {15649704},
  url     = {https://doi.org/10.1016/j.nbd.2004.09.009}
}

@article{mcgeer1998-9762518,
  author  = {McGeer, E. G. and McGeer, P. L.},
  title   = {{The importance of inflammatory mechanisms in Alzheimer disease}},
  journal = {Experimental gerontology},
  year    = {1998},
  doi     = {10.1016/s0531-5565(98)00013-8},
  pmid    = {9762518},
  url     = {https://doi.org/10.1016/s0531-5565(98)00013-8}
}

@article{sanz2009-19299738,
  author  = {Sanz, J. M. and Chiozzi, P. and Ferrari, D. and Colaianna, M. and Idzko, M. and Falzoni, S. and Fellin, R. and Trabace, L. and others},
  title   = {{Activation of microglia by amyloid beta requires P2X7 receptor expression}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2009},
  doi     = {10.4049/jimmunol.0803612},
  pmid    = {19299738},
  url     = {https://doi.org/10.4049/jimmunol.0803612}
}

@article{bonifati2007-16698083,
  author  = {Bonifati, D. M. and Kishore, U.},
  title   = {{Role of complement in neurodegeneration and neuroinflammation}},
  journal = {Molecular immunology},
  year    = {2007},
  doi     = {10.1016/j.molimm.2006.03.007},
  pmid    = {16698083},
  url     = {https://doi.org/10.1016/j.molimm.2006.03.007}
}

@article{majumdar2007-17314396,
  author  = {Majumdar, A. and Cruz, D. and Asamoah, N. and Buxbaum, A. and Sohar, I. and Lobel, P. and Maxfield, F. R.},
  title   = {{Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils}},
  journal = {Molecular biology of the cell},
  year    = {2007},
  doi     = {10.1091/mbc.e06-10-0975},
  pmid    = {17314396},
  url     = {https://doi.org/10.1091/mbc.e06-10-0975}
}

@article{persidsky1999-10550317,
  author  = {Persidsky, Y. and Ghorpade, A. and Rasmussen, J. and Limoges, J. and Liu, X. J. and Stins, M. and Fiala, M. and Way, D. and others},
  title   = {{Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis}},
  journal = {The American journal of pathology},
  year    = {1999},
  doi     = {10.1016/s0002-9440(10)65476-4},
  pmid    = {10550317},
  url     = {https://doi.org/10.1016/s0002-9440(10)65476-4}
}

@article{seo2018-29179999,
  author  = {Seo, E. J. and Fischer, N. and Efferth, T.},
  title   = {{Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease}},
  journal = {Pharmacological research},
  year    = {2018},
  doi     = {10.1016/j.phrs.2017.11.030},
  pmid    = {29179999},
  url     = {https://doi.org/10.1016/j.phrs.2017.11.030}
}

@article{grundkeiqbal1990-2082650,
  author  = {Grundke-Iqbal, I. and Fleming, J. and Tung, Y. C. and Lassmann, H. and Iqbal, K. and Joshi, J. G.},
  title   = {{Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia}},
  journal = {Acta neuropathologica},
  year    = {1990},
  doi     = {10.1007/bf00334497},
  pmid    = {2082650},
  url     = {https://doi.org/10.1007/bf00334497}
}

@article{garwood2017-27442752,
  author  = {Garwood, C. J. and Ratcliffe, L. E. and Simpson, J. E. and Heath, P. R. and Ince, P. G. and Wharton, S. B.},
  title   = {{Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role}},
  journal = {Neuropathology and applied neurobiology},
  year    = {2017},
  doi     = {10.1111/nan.12338},
  pmid    = {27442752},
  url     = {https://doi.org/10.1111/nan.12338}
}

@article{pabon2011-21266082,
  author  = {Pabon, M. M. and Bachstetter, A. D. and Hudson, C. E. and Gemma, C. and Bickford, P. C.},
  title   = {{CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2011},
  doi     = {10.1186/1742-2094-8-9},
  pmid    = {21266082},
  url     = {https://doi.org/10.1186/1742-2094-8-9}
}

@article{weiss1999-10453044,
  author  = {Weiss, J. M. and Nath, A. and Major, E. O. and Berman, J. W.},
  title   = {{HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {1999},
  doi     = {10.4049/jimmunol.163.5.2953},
  pmid    = {10453044},
  url     = {https://doi.org/10.4049/jimmunol.163.5.2953}
}

@article{muddapu2020-32296300,
  author  = {Muddapu, V. R. and Dharshini, S. A. P. and Chakravarthy, V. S. and Gromiha, M. M.},
  title   = {{Neurodegenerative Diseases - Is Metabolic Deficiency the Root Cause?}},
  journal = {Frontiers in neuroscience},
  year    = {2020},
  doi     = {10.3389/fnins.2020.00213},
  pmid    = {32296300},
  url     = {https://doi.org/10.3389/fnins.2020.00213}
}

@article{rhinn2022-35039149,
  author  = {Rhinn, H. and Tatton, N. and McCaughey, S. and Kurnellas, M. and Rosenthal, A.},
  title   = {{Progranulin as a therapeutic target in neurodegenerative diseases}},
  journal = {Trends in pharmacological sciences},
  year    = {2022},
  doi     = {10.1016/j.tips.2021.11.015},
  pmid    = {35039149},
  url     = {https://doi.org/10.1016/j.tips.2021.11.015}
}

@article{faraco2017-28782084,
  author  = {Faraco, G. and Park, L. and Anrather, J. and Iadecola, C.},
  title   = {{Brain perivascular macrophages: characterization and functional roles in health and disease}},
  journal = {Journal of molecular medicine (Berlin, Germany)},
  year    = {2017},
  doi     = {10.1007/s00109-017-1573-x},
  pmid    = {28782084},
  url     = {https://doi.org/10.1007/s00109-017-1573-x}
}

@article{mori2010-19705461,
  author  = {Mori, T. and Koyama, N. and Arendash, G. W. and Horikoshi-Sakuraba, Y. and Tan, J. and Town, T.},
  title   = {{Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease}},
  journal = {Glia},
  year    = {2010},
  doi     = {10.1002/glia.20924},
  pmid    = {19705461},
  url     = {https://doi.org/10.1002/glia.20924}
}

@article{aso2013-23515018,
  author  = {Aso, E. and Juvés, S. and Maldonado, R. and Ferrer, I.},
  title   = {{CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-130137},
  pmid    = {23515018},
  url     = {https://doi.org/10.3233/jad-130137}
}

@article{kenkhuis2022-35247551,
  author  = {Kenkhuis, B. and Somarakis, A. and Kleindouwel, L. R. T. and van Roon-Mom, W. M. C. and Höllt, T. and van der Weerd, L.},
  title   = {{Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105684},
  pmid    = {35247551},
  url     = {https://doi.org/10.1016/j.nbd.2022.105684}
}

@article{aso2014-24634659,
  author  = {Aso, E. and Ferrer, I.},
  title   = {{Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic}},
  journal = {Frontiers in pharmacology},
  year    = {2014},
  doi     = {10.3389/fphar.2014.00037},
  pmid    = {24634659},
  url     = {https://doi.org/10.3389/fphar.2014.00037}
}

@article{umoh2018-29191947,
  author  = {Umoh, M. E. and Dammer, E. B. and Dai, J. and Duong, D. M. and Lah, J. J. and Levey, A. I. and Gearing, M. and Glass, J. D. and others},
  title   = {{A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain}},
  journal = {EMBO molecular medicine},
  year    = {2018},
  doi     = {10.15252/emmm.201708202},
  pmid    = {29191947},
  url     = {https://doi.org/10.15252/emmm.201708202}
}

@article{barnett2025-41188644,
  author  = {BARNETT, DANIEL H. and Zimmer, Till S. and Booraem, Caroline and Palaguachi, Fernando and Meadows, Samantha M. and Xiao, Haopeng and Wong, Man Ying and Luo, Wenjie and others},
  title   = {{Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology}},
  journal = {Nature Metabolism},
  year    = {2025},
  doi     = {10.1038/s42255-025-01390-y},
  pmid    = {41188644},
  url     = {https://doi.org/10.1038/s42255-025-01390-y}
}

@article{bosworth2025-40048429,
  author  = {Bosworth, Alexandra P and Contreras, Minerva and Sancho, Laura and Salas, Isabel H. and Paumier, Adrien and Novak, Sammy Weiser and Manor, Uri and Allen, Nicola J.},
  title   = {{Astrocyte glypican 5 regulates synapse maturation and stabilization}},
  journal = {Cell Reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.115374},
  pmid    = {40048429},
  url     = {https://doi.org/10.1016/j.celrep.2025.115374}
}

@article{brandao2025-39813317,
  author  = {Brandão, Wesley Nogueira and Jain, Nimansha and Yin, Zhuoran and Kleemann, Kilian L. and Carpenter, Madison and Bao, Xin and Serrano, Javier Remolina and Tycksen, Eric and others},
  title   = {{Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy}},
  journal = {Science Translational Medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.adk3690},
  pmid    = {39813317},
  url     = {https://doi.org/10.1126/scitranslmed.adk3690}
}

@article{bacci2025-41476029,
  author  = {Bacci, Julia R. and Ryan, Joanne L. and Murray, Anne M. and Wu, Zimu and Woods, Robyn L. and Berk, Michael and Mielke, Michelle M.},
  title   = {{The association of Alzheimer's disease and related dementias blood‐based biomarkers with depressive symptoms}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.71007},
  pmid    = {41476029},
  url     = {https://doi.org/10.1002/alz.71007}
}

@article{chen2026-dd40034c,
  author  = {Chen, Robin and Chiu, Shannon and DeSimone, Jesse C. and Wang, Wei and Barmpoutis, Angelos and McMillan, Corey T. and Radhakrishnan, Hamsanandini and Irwin, David John and others},
  title   = {{Automated Imaging Differentiation for Dementia}},
  journal = {Neurology Open Access},
  year    = {2026},
  doi     = {10.1212/wn9.0000000000000093},
  url     = {https://doi.org/10.1212/wn9.0000000000000093}
}

@article{hartmann2024-38528004,
  author  = {Hartmann, Jakob and Bajaj, Thomas and Otten, Joy and Klengel, Claudia and Ebert, Tim and Gellner, Anne-Kathrin and Junglas, Ellen and Hafner, Kathrin and others},
  title   = {{SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-46953-x},
  pmid    = {38528004},
  url     = {https://doi.org/10.1038/s41467-024-46953-x}
}

@article{riversauty2024-39229486,
  author  = {Rivers-Auty, Jack and Hoyle, Christopher and Pointer, Ayesha and Lawrence, Catherine and Pickering-Brown, Stuart and Brough, David and Ryan, Sarah},
  title   = {{C9orf72 dipeptides activate the NLRP3 inflammasome}},
  journal = {Brain communications},
  year    = {2024},
  doi     = {10.1093/braincomms/fcae282},
  pmid    = {39229486},
  url     = {https://doi.org/10.1093/braincomms/fcae282}
}

@article{stoll1999-10341362,
  author  = {Stoll, G. and Jander, S.},
  title   = {{The role of microglia and macrophages in the pathophysiology of the CNS}},
  journal = {Progress in neurobiology},
  year    = {1999},
  doi     = {10.1016/s0301-0082(98)00083-5},
  pmid    = {10341362},
  url     = {https://doi.org/10.1016/s0301-0082(98)00083-5}
}

@article{merazrios2013-23964211,
  author  = {Meraz-Ríos, M. A. and Toral-Rios, D. and Franco-Bocanegra, D. and Villeda-Hernández, J. and Campos-Peña, V.},
  title   = {{Inflammatory process in Alzheimer's Disease}},
  journal = {Frontiers in integrative neuroscience},
  year    = {2013},
  doi     = {10.3389/fnint.2013.00059},
  pmid    = {23964211},
  url     = {https://doi.org/10.3389/fnint.2013.00059}
}

@article{chitu2016-27083478,
  author  = {Chitu, V. and Ş, Gokhan and Nandi, S. and Mehler, M. F. and Stanley, E. R.},
  title   = {{Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System}},
  journal = {Trends in neurosciences},
  year    = {2016},
  doi     = {10.1016/j.tins.2016.03.005},
  pmid    = {27083478},
  url     = {https://doi.org/10.1016/j.tins.2016.03.005}
}

@article{thirumangalakudi2008-18410513,
  author  = {Thirumangalakudi, L. and Prakasam, A. and Zhang, R. and Bimonte-Nelson, H. and Sambamurti, K. and Kindy, M. S. and Bhat, N. R.},
  title   = {{High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2008.05415.x},
  pmid    = {18410513},
  url     = {https://doi.org/10.1111/j.1471-4159.2008.05415.x}
}

@article{venneti2006-17156911,
  author  = {Venneti, S. and Lopresti, B. J. and Wiley, C. A.},
  title   = {{The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging}},
  journal = {Progress in neurobiology},
  year    = {2006},
  doi     = {10.1016/j.pneurobio.2006.10.002},
  pmid    = {17156911},
  url     = {https://doi.org/10.1016/j.pneurobio.2006.10.002}
}

@article{lee2002-12111820,
  author  = {Lee, Y. B. and Nagai, A. and Kim, S. U.},
  title   = {{Cytokines, chemokines, and cytokine receptors in human microglia}},
  journal = {Journal of neuroscience research},
  year    = {2002},
  doi     = {10.1002/jnr.10253},
  pmid    = {12111820},
  url     = {https://doi.org/10.1002/jnr.10253}
}

@article{griffin2006-16470015,
  author  = {Griffin, W. S.},
  title   = {{Inflammation and neurodegenerative diseases}},
  journal = {The American journal of clinical nutrition},
  year    = {2006},
  doi     = {10.1093/ajcn/83.2.470s},
  pmid    = {16470015},
  url     = {https://doi.org/10.1093/ajcn/83.2.470s}
}

@article{lin2020-31765741,
  author  = {Lin, X. and Chen, Y. and Zhang, P. and Chen, G. and Zhou, Y. and Yu, X.},
  title   = {{The potential mechanism of postoperative cognitive dysfunction in older people}},
  journal = {Experimental gerontology},
  year    = {2020},
  doi     = {10.1016/j.exger.2019.110791},
  pmid    = {31765741},
  url     = {https://doi.org/10.1016/j.exger.2019.110791}
}

@article{kang2005-15927426,
  author  = {Kang, D. C. and Su, Z. Z. and Sarkar, D. and Emdad, L. and Volsky, D. J. and Fisher, P. B.},
  title   = {{Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1}},
  journal = {Gene},
  year    = {2005},
  doi     = {10.1016/j.gene.2005.04.006},
  pmid    = {15927426},
  url     = {https://doi.org/10.1016/j.gene.2005.04.006}
}

@article{mclarnon2006-17086106,
  author  = {McLarnon, J. G. and Ryu, J. K. and Walker, D. G. and Choi, H. B.},
  title   = {{Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000240470.97295.d3},
  pmid    = {17086106},
  url     = {https://doi.org/10.1097/01.jnen.0000240470.97295.d3}
}

@article{zhang2015-25673992,
  author  = {Zhang, F. and Jiang, L.},
  title   = {{Neuroinflammation in Alzheimer's disease}},
  journal = {Neuropsychiatric disease and treatment},
  year    = {2015},
  doi     = {10.2147/ndt.s75546},
  pmid    = {25673992},
  url     = {https://doi.org/10.2147/ndt.s75546}
}

@article{nwaobi2016-26961251,
  author  = {Nwaobi, S. E. and Cuddapah, V. A. and Patterson, K. C. and Randolph, A. C. and Olsen, M. L.},
  title   = {{The role of glial-specific Kir4.1 in normal and pathological states of the CNS}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-016-1553-1},
  pmid    = {26961251},
  url     = {https://doi.org/10.1007/s00401-016-1553-1}
}

@article{gorry2001-11581376,
  author  = {Gorry, P. R. and Bristol, G. and Zack, J. A. and Ritola, K. and Swanstrom, R. and Birch, C. J. and Bell, J. E. and Bannert, N. and others},
  title   = {{Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity}},
  journal = {Journal of virology},
  year    = {2001},
  doi     = {10.1128/jvi.75.21.10073-10089.2001},
  pmid    = {11581376},
  url     = {https://doi.org/10.1128/jvi.75.21.10073-10089.2001}
}

@article{lee2010-20228251,
  author  = {Lee, M. and Cho, T. and Jantaratnotai, N. and Wang, Y. T. and McGeer, E. and McGeer, P. L.},
  title   = {{Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2010},
  doi     = {10.1096/fj.09-149997},
  pmid    = {20228251},
  url     = {https://doi.org/10.1096/fj.09-149997}
}

@article{acosta2017-28467650,
  author  = {Acosta, C. and Anderson, H. D. and Anderson, C. M.},
  title   = {{Astrocyte dysfunction in Alzheimer disease}},
  journal = {Journal of neuroscience research},
  year    = {2017},
  doi     = {10.1002/jnr.24075},
  pmid    = {28467650},
  url     = {https://doi.org/10.1002/jnr.24075}
}

@article{xia1999-10190688,
  author  = {Xia, M. Q. and Hyman, B. T.},
  title   = {{Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease}},
  journal = {Journal of neurovirology},
  year    = {1999},
  doi     = {10.3109/13550289909029743},
  pmid    = {10190688},
  url     = {https://doi.org/10.3109/13550289909029743}
}

@article{wilkinson2006-17094809,
  author  = {Wilkinson, B. L. and Landreth, G. E.},
  title   = {{The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-30},
  pmid    = {17094809},
  url     = {https://doi.org/10.1186/1742-2094-3-30}
}

@article{gao2012-22503440,
  author  = {Gao, H. M. and Zhou, H. and Hong, J. S.},
  title   = {{NADPH oxidases: novel therapeutic targets for neurodegenerative diseases}},
  journal = {Trends in pharmacological sciences},
  year    = {2012},
  doi     = {10.1016/j.tips.2012.03.008},
  pmid    = {22503440},
  url     = {https://doi.org/10.1016/j.tips.2012.03.008}
}

@article{dandrea2004-15172747,
  author  = {D'Andrea, M. R. and Cole, G. M. and Ard, M. D.},
  title   = {{The microglial phagocytic role with specific plaque types in the Alzheimer disease brain}},
  journal = {Neurobiology of aging},
  year    = {2004},
  doi     = {10.1016/j.neurobiolaging.2003.12.026},
  pmid    = {15172747},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2003.12.026}
}

@article{parachikova2007-17052803,
  author  = {Parachikova, A. and Agadjanyan, M. G. and Cribbs, D. H. and Blurton-Jones, M. and Perreau, V. and Rogers, J. and Beach, T. G. and Cotman, C. W.},
  title   = {{Inflammatory changes parallel the early stages of Alzheimer disease}},
  journal = {Neurobiology of aging},
  year    = {2007},
  doi     = {10.1016/j.neurobiolaging.2006.08.014},
  pmid    = {17052803},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2006.08.014}
}

@article{medeiros2013-23063604,
  author  = {Medeiros, R. and LaFerla, F. M.},
  title   = {{Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony}},
  journal = {Experimental neurology},
  year    = {2013},
  doi     = {10.1016/j.expneurol.2012.10.007},
  pmid    = {23063604},
  url     = {https://doi.org/10.1016/j.expneurol.2012.10.007}
}

@article{currais2014-24341874,
  author  = {Currais, A. and Prior, M. and Dargusch, R. and Armando, A. and Ehren, J. and Schubert, D. and Quehenberger, O. and Maher, P.},
  title   = {{Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice}},
  journal = {Aging cell},
  year    = {2014},
  doi     = {10.1111/acel.12185},
  pmid    = {24341874},
  url     = {https://doi.org/10.1111/acel.12185}
}

@article{cordle2005-16085653,
  author  = {Cordle, A. and Koenigsknecht-Talboo, J. and Wilkinson, B. and Limpert, A. and Landreth, G.},
  title   = {{Mechanisms of statin-mediated inhibition of small G-protein function}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m505268200},
  pmid    = {16085653},
  url     = {https://doi.org/10.1074/jbc.m505268200}
}

@article{brew1995-7574452,
  author  = {Brew, B. J. and Rosenblum, M. and Cronin, K. and Price, R. W.},
  title   = {{AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations}},
  journal = {Annals of neurology},
  year    = {1995},
  doi     = {10.1002/ana.410380404},
  pmid    = {7574452},
  url     = {https://doi.org/10.1002/ana.410380404}
}

@article{sheng1998-9542587,
  author  = {Sheng, J. G. and Mrak, R. E. and Griffin, W. S.},
  title   = {{Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain}},
  journal = {Acta neuropathologica},
  year    = {1998},
  doi     = {10.1007/s004010050792},
  pmid    = {9542587},
  url     = {https://doi.org/10.1007/s004010050792}
}

@article{vehmas2003-12498966,
  author  = {Vehmas, A. K. and Kawas, C. H. and Stewart, W. F. and Troncoso, J. C.},
  title   = {{Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2003},
  doi     = {10.1016/s0197-4580(02)00090-8},
  pmid    = {12498966},
  url     = {https://doi.org/10.1016/s0197-4580(02)00090-8}
}

@article{rosenberg2001-11340226,
  author  = {Rosenberg, G. A. and Sullivan, N. and Esiri, M. M.},
  title   = {{White matter damage is associated with matrix metalloproteinases in vascular dementia}},
  journal = {Stroke},
  year    = {2001},
  doi     = {10.1161/01.str.32.5.1162},
  pmid    = {11340226},
  url     = {https://doi.org/10.1161/01.str.32.5.1162}
}

@article{chen2023-36455485,
  author  = {Chen, L. L. and Fan, Y. G. and Zhao, L. X. and Zhang, Q. and Wang, Z. Y.},
  title   = {{The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators}},
  journal = {Bioorganic chemistry},
  year    = {2023},
  doi     = {10.1016/j.bioorg.2022.106301},
  pmid    = {36455485},
  url     = {https://doi.org/10.1016/j.bioorg.2022.106301}
}

@article{gamba2015-26150787,
  author  = {Gamba, P. and Testa, G. and Gargiulo, S. and Staurenghi, E. and Poli, G. and Leonarduzzi, G.},
  title   = {{Oxidized cholesterol as the driving force behind the development of Alzheimer's disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2015},
  doi     = {10.3389/fnagi.2015.00119},
  pmid    = {26150787},
  url     = {https://doi.org/10.3389/fnagi.2015.00119}
}

@article{mwale2025-39827337,
  author  = {Mwale, Pharaoh Fellow and Hsieh, Cheng-Ta and Yen, Ting‐Lin and Jan, Jing‐Shiun and Taliyan, Rajeev and Yang, Chih‐Hao and Yang, Wen‐Bin},
  title   = {{Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00801-8},
  pmid    = {39827337},
  url     = {https://doi.org/10.1186/s13024-025-00801-8}
}

@article{daponte2025-41097004,
  author  = {Daponte, Ariadne and Koros, Christos and Skarlis, Charalampos and Siozios, Daphne and Rentzos, Michail and Papageorgiou, Sokratis G. and Anagnostouli, Maria C.},
  title   = {{Neurofilament Biomarkers in Neurology: From Neuroinflammation to Neurodegeneration, Bridging Established and Novel Analytical Advances with Clinical Practice}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26199739},
  pmid    = {41097004},
  url     = {https://doi.org/10.3390/ijms26199739}
}

@article{prajapati2025-40036891,
  author  = {Prajapati, Santosh Kumar and Jain, Shalini and Yadav, Hariom},
  title   = {{Age-Related Cognitive Decline and Dementia: Interface of Microbiome–Immune–Neuronal Interactions}},
  journal = {The Journals of Gerontology Series A},
  year    = {2025},
  doi     = {10.1093/gerona/glaf038},
  pmid    = {40036891},
  url     = {https://doi.org/10.1093/gerona/glaf038}
}

@article{luo2026-41578396,
  author  = {Luo, Lixin and Qiao, Song},
  title   = {{Neuroinflammation and blood–brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications}},
  journal = {European journal of medical research},
  year    = {2026},
  doi     = {10.1186/s40001-026-03840-z},
  pmid    = {41578396},
  url     = {https://doi.org/10.1186/s40001-026-03840-z}
}

@article{ziegler2025-41173000,
  author  = {Ziegler, Kevin Chris and Askarova, Aydan and Gergian, Charbel and Yaa, Reuben M and van Dalen, Janna D. and Transfeld, Janis Lisa and Zoppi, Filippo and Du, Jia and others},
  title   = {{The brain neurovascular epigenome and its association with dementia}},
  journal = {Neuron},
  year    = {2025},
  doi     = {10.1016/j.neuron.2025.10.001},
  pmid    = {41173000},
  url     = {https://doi.org/10.1016/j.neuron.2025.10.001}
}

@article{brezani2025-40665351,
  author  = {Brezáni, Veronika and Joshi, Radhika and Ortega‐Ribera, Martí and Nagesh, Prashanth Thevkar and Zivny, Adam and Kurt‐Jones, Evelyn A. and Golenbock, Douglas Taylor and others},
  title   = {{Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03501-8},
  pmid    = {40665351},
  url     = {https://doi.org/10.1186/s12974-025-03501-8}
}

@article{chia2025-40826098,
  author  = {Chia, Sook‐Yoong and Li, Mengwei and Li, Zigang and Tu, Haitao and Lee, Jolene Wei Ling and Qiu, Lifeng and Ling, Jingjing and Reynolds, Richard J. and others},
  title   = {{Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes}},
  journal = {Genome Medicine},
  year    = {2025},
  doi     = {10.1186/s13073-025-01519-4},
  pmid    = {40826098},
  url     = {https://doi.org/10.1186/s13073-025-01519-4}
}

@article{wang2026-41980911,
  author  = {Wang, Meng and Buthut, Maria and Meinhardt, Jenny and Otto, Carolin and Gallaccio, Gerardina and Fernández‐Zapata, Camila and Teves, Matteo and Samol, Claudia and others},
  title   = {{Immune–proteo–metabolomic changes link to Aβ and tau pathology in Alzheimer disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71359},
  pmid    = {41980911},
  url     = {https://doi.org/10.1002/alz.71359}
}

@article{dunfee2006-17015824,
  author  = {Dunfee, R. L. and Thomas, E. R. and Gorry, P. R. and Wang, J. and Taylor, J. and Kunstman, K. and Wolinsky, S. M. and Gabuzda, D.},
  title   = {{The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0605513103},
  pmid    = {17015824},
  url     = {https://doi.org/10.1073/pnas.0605513103}
}

@article{cattaneo2017-27776263,
  author  = {Cattaneo, A. and Cattane, N. and Galluzzi, S. and Provasi, S. and Lopizzo, N. and Festari, C. and Ferrari, C. and Guerra, U. P. and others},
  title   = {{Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2016.08.019},
  pmid    = {27776263},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.08.019}
}

@article{spangenberg2019-31434879,
  author  = {Spangenberg, E. and Severson, P. L. and Hohsfield, L. A. and Crapser, J. and Zhang, J. and Burton, E. A. and Zhang, Y. and Spevak, W. and others},
  title   = {{Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model}},
  journal = {Nature communications},
  year    = {2019},
  doi     = {10.1038/s41467-019-11674-z},
  pmid    = {31434879},
  url     = {https://doi.org/10.1038/s41467-019-11674-z}
}

@article{liebner2018-29411111,
  author  = {Liebner, S. and Dijkhuizen, R. M. and Reiss, Y. and Plate, K. H. and Agalliu, D. and Constantin, G.},
  title   = {{Functional morphology of the blood-brain barrier in health and disease}},
  journal = {Acta neuropathologica},
  year    = {2018},
  doi     = {10.1007/s00401-018-1815-1},
  pmid    = {29411111},
  url     = {https://doi.org/10.1007/s00401-018-1815-1}
}

@article{moonen2023-36481964,
  author  = {Moonen, Sebastiaan and Koper, Marta J and Van Schoor, Evelien and Schaeverbeke, Jolien M and Vandenberghe, Rik and von Arnim, Christine A F and Tousseyn, Thomas and De Strooper, Bart and others},
  title   = {{Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons}},
  journal = {Acta neuropathologica},
  year    = {2023},
  doi     = {10.1007/s00401-022-02528-y},
  pmid    = {36481964},
  url     = {https://doi.org/10.1007/s00401-022-02528-y}
}

@article{zeenny2026-42377782,
  author  = {Zeenny, Marie-Noel and Salame, Ingrid and Maatouk, Lynn and Akoury, Elias},
  title   = {{Neuroinflammation and Tauopathies}},
  journal = {Molecular biology reports},
  year    = {2026},
  doi     = {10.1007/s11033-026-12253-4},
  pmid    = {42377782},
  url     = {https://doi.org/10.1007/s11033-026-12253-4}
}

@article{chou2023-38016942,
  author  = {Chou, Vicky and Pearse, Richard V and Aylward, Aimee J and Ashour, Nancy and Taga, Mariko and Terzioglu, Gizem and Fujita, Masashi and Fancher, Seeley B and others},
  title   = {{INPP5D regulates inflammasome activation in human microglia}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-42819-w},
  pmid    = {38016942},
  url     = {https://doi.org/10.1038/s41467-023-42819-w}
}

@article{lopezrodriguez2021-34080771,
  author  = {Lopez-Rodriguez, Ana Belen and Hennessy, Edel and Murray, Carol L and Nazmi, Arshed and Delaney, Hugh J and Healy, Dáire and Fagan, Steven G and Rooney, Michael and others},
  title   = {{Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12341},
  pmid    = {34080771},
  url     = {https://doi.org/10.1002/alz.12341}
}

@article{kim2026-41673711,
  author  = {Kim, Yeji and Ha, Tae-Young and Kondaurova, Oksana and Lee, Myung-Shik and Chang, Keun-A},
  title   = {{Microglia TFEB activation attenuates Alzheimer's disease pathology by enhancing autophagy-lysosomal function}},
  journal = {Journal of neuroinflammation},
  year    = {2026},
  doi     = {10.1186/s12974-026-03728-z},
  pmid    = {41673711},
  url     = {https://doi.org/10.1186/s12974-026-03728-z}
}

@article{chen2023-36835494,
  author  = {Chen, Yi-Chun and Chang, Shih-Cheng and Lee, Yun-Shien and Ho, Wei-Min and Huang, Yu-Hua and Wu, Yah-Yuan and Chu, Yi-Chuan and Wu, Kuan-Hsuan and others},
  title   = {{TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24044085},
  pmid    = {36835494},
  url     = {https://doi.org/10.3390/ijms24044085}
}

@article{kim2021-33382892,
  author  = {Kim, Jong-Heon and Afridi, Ruqayya and Han, Jin and Jung, Hyun-Gug and Kim, Seung-Chan and Hwang, Eun Mi and Shim, Hyun Soo and Ryu, Hoon and others},
  title   = {{Gamma subunit of complement component 8 is a neuroinflammation inhibitor}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awaa425},
  pmid    = {33382892},
  url     = {https://doi.org/10.1093/brain/awaa425}
}

@article{yao2023-37670126,
  author  = {Yao, Jing and Wang, Zhe and Song, Weihong and Zhang, Yun},
  title   = {{Targeting NLRP3 inflammasome for neurodegenerative disorders}},
  journal = {Molecular psychiatry},
  year    = {2023},
  doi     = {10.1038/s41380-023-02239-0},
  pmid    = {37670126},
  url     = {https://doi.org/10.1038/s41380-023-02239-0}
}

@article{li2026-41734021,
  author  = {Li, Tao and Castro-Gomez, Sergio and Lucena, Pablo Botella and Vieira-Saecker, Ana and Schwartz, Stephanie and Ding, Yingying and Deng, Yushuang and Gou, Maling and others},
  title   = {{Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model}},
  journal = {The Journal of clinical investigation},
  year    = {2026},
  doi     = {10.1172/jci199818},
  pmid    = {41734021},
  url     = {https://doi.org/10.1172/jci199818}
}

@article{minghetti2004-15453089,
  author  = {Minghetti, L.},
  title   = {{Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2004},
  doi     = {10.1093/jnen/63.9.901},
  pmid    = {15453089},
  url     = {https://doi.org/10.1093/jnen/63.9.901}
}

@article{minagar2002-12220687,
  author  = {Minagar, A. and Shapshak, P. and Fujimura, R. and Ownby, R. and Heyes, M. and Eisdorfer, C.},
  title   = {{The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis}},
  journal = {Journal of the neurological sciences},
  year    = {2002},
  doi     = {10.1016/s0022-510x(02)00207-1},
  pmid    = {12220687},
  url     = {https://doi.org/10.1016/s0022-510x(02)00207-1}
}

@article{mcgeer2001-11754986,
  author  = {McGeer, P. L. and McGeer, E. G.},
  title   = {{Inflammation, autotoxicity and Alzheimer disease}},
  journal = {Neurobiology of aging},
  year    = {2001},
  doi     = {10.1016/s0197-4580(01)00289-5},
  pmid    = {11754986},
  url     = {https://doi.org/10.1016/s0197-4580(01)00289-5}
}

@article{akiyama1990-1977769,
  author  = {Akiyama, H. and McGeer, P. L.},
  title   = {{Brain microglia constitutively express beta-2 integrins}},
  journal = {Journal of neuroimmunology},
  year    = {1990},
  doi     = {10.1016/0165-5728(90)90055-r},
  pmid    = {1977769},
  url     = {https://doi.org/10.1016/0165-5728(90)90055-r}
}

@article{mrak2001-11754997,
  author  = {Mrak, R. E. and Griffin, W. S.},
  title   = {{Interleukin-1, neuroinflammation, and Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2001},
  doi     = {10.1016/s0197-4580(01)00287-1},
  pmid    = {11754997},
  url     = {https://doi.org/10.1016/s0197-4580(01)00287-1}
}

@article{merrill1991-2065887,
  author  = {Merrill, J. E. and Chen, I. S.},
  title   = {{HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {1991},
  doi     = {10.1096/fasebj.5.10.2065887},
  pmid    = {2065887},
  url     = {https://doi.org/10.1096/fasebj.5.10.2065887}
}

@article{faden2016-25939377,
  author  = {Faden, A. I. and Wu, J. and Stoica, B. A. and Loane, D. J.},
  title   = {{Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury}},
  journal = {British journal of pharmacology},
  year    = {2016},
  doi     = {10.1111/bph.13179},
  pmid    = {25939377},
  url     = {https://doi.org/10.1111/bph.13179}
}

@article{bajetto2002-12354279,
  author  = {Bajetto, A. and Bonavia, R. and Barbero, S. and Schettini, G.},
  title   = {{Characterization of chemokines and their receptors in the central nervous system: physiopathological implications}},
  journal = {Journal of neurochemistry},
  year    = {2002},
  doi     = {10.1046/j.1471-4159.2002.01091.x},
  pmid    = {12354279},
  url     = {https://doi.org/10.1046/j.1471-4159.2002.01091.x}
}

@article{rosalescorral2012-22107053,
  author  = {Rosales-Corral, S. A. and Acuña-Castroviejo, D. and Coto-Montes, A. and Boga, J. A. and Manchester, L. C. and Fuentes-Broto, L. and Korkmaz, A. and Ma, S. and others},
  title   = {{Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin}},
  journal = {Journal of pineal research},
  year    = {2012},
  doi     = {10.1111/j.1600-079x.2011.00937.x},
  pmid    = {22107053},
  url     = {https://doi.org/10.1111/j.1600-079x.2011.00937.x}
}

@article{pisanu2014-25134730,
  author  = {Pisanu, A. and Lecca, D. and Mulas, G. and Wardas, J. and Simbula, G. and Spiga, S. and Carta, A. R.},
  title   = {{Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease}},
  journal = {Neurobiology of disease},
  year    = {2014},
  doi     = {10.1016/j.nbd.2014.08.011},
  pmid    = {25134730},
  url     = {https://doi.org/10.1016/j.nbd.2014.08.011}
}

@article{takeuchi2005-15640150,
  author  = {Takeuchi, H. and Mizuno, T. and Zhang, G. and Wang, J. and Kawanokuchi, J. and Kuno, R. and Suzumura, A.},
  title   = {{Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m413863200},
  pmid    = {15640150},
  url     = {https://doi.org/10.1074/jbc.m413863200}
}

@article{albright1999-9847323,
  author  = {Albright, A. V. and Shieh, J. T. and Itoh, T. and Lee, B. and Pleasure, D. and O'Connor, M. J. and Doms, R. W. and González-Scarano, F.},
  title   = {{Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates}},
  journal = {Journal of virology},
  year    = {1999},
  doi     = {10.1128/jvi.73.1.205-213.1999},
  pmid    = {9847323},
  url     = {https://doi.org/10.1128/jvi.73.1.205-213.1999}
}

@article{itagaki1988-2972943,
  author  = {Itagaki, S. and McGeer, P. L. and Akiyama, H.},
  title   = {{Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue}},
  journal = {Neuroscience letters},
  year    = {1988},
  doi     = {10.1016/0304-3940(88)90690-8},
  pmid    = {2972943},
  url     = {https://doi.org/10.1016/0304-3940(88)90690-8}
}

@article{anthony2005-15977645,
  author  = {Anthony, I. C. and Ramage, S. N. and Carnie, F. W. and Simmonds, P. and Bell, J. E.},
  title   = {{Influence of HAART on HIV-related CNS disease and neuroinflammation}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2005},
  doi     = {10.1093/jnen/64.6.529},
  pmid    = {15977645},
  url     = {https://doi.org/10.1093/jnen/64.6.529}
}

@article{perlmutter1992-1484388,
  author  = {Perlmutter, L. S. and Scott, S. A. and Barrón, E. and Chui, H. C.},
  title   = {{MHC class II-positive microglia in human brain: association with Alzheimer lesions}},
  journal = {Journal of neuroscience research},
  year    = {1992},
  doi     = {10.1002/jnr.490330407},
  pmid    = {1484388},
  url     = {https://doi.org/10.1002/jnr.490330407}
}

@article{rossi2009-19631259,
  author  = {Rossi, D. and Volterra, A.},
  title   = {{Astrocytic dysfunction: insights on the role in neurodegeneration}},
  journal = {Brain research bulletin},
  year    = {2009},
  doi     = {10.1016/j.brainresbull.2009.07.012},
  pmid    = {19631259},
  url     = {https://doi.org/10.1016/j.brainresbull.2009.07.012}
}

@article{tsai2016-27318702,
  author  = {Tsai, H. C. and Han, M. H.},
  title   = {{Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation}},
  journal = {Drugs},
  year    = {2016},
  doi     = {10.1007/s40265-016-0603-2},
  pmid    = {27318702},
  url     = {https://doi.org/10.1007/s40265-016-0603-2}
}

@article{ahmad2016-27211305,
  author  = {Ahmad, L. and Zhang, S. Y. and Casanova, J. L. and Sancho-Shimizu, V.},
  title   = {{Human TBK1: A Gatekeeper of Neuroinflammation}},
  journal = {Trends in molecular medicine},
  year    = {2016},
  doi     = {10.1016/j.molmed.2016.04.006},
  pmid    = {27211305},
  url     = {https://doi.org/10.1016/j.molmed.2016.04.006}
}

@article{iannaccone2013-22841687,
  author  = {Iannaccone, S. and Cerami, C. and Alessio, M. and Garibotto, V. and Panzacchi, A. and Olivieri, S. and Gelsomino, G. and Moresco, R. M. and others},
  title   = {{In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease}},
  journal = {Parkinsonism \& related disorders},
  year    = {2013},
  doi     = {10.1016/j.parkreldis.2012.07.002},
  pmid    = {22841687},
  url     = {https://doi.org/10.1016/j.parkreldis.2012.07.002}
}

@article{jevtic2017-28941639,
  author  = {Jevtic, S. and Sengar, A. S. and Salter, M. W. and McLaurin, J.},
  title   = {{The role of the immune system in Alzheimer disease: Etiology and treatment}},
  journal = {Ageing research reviews},
  year    = {2017},
  doi     = {10.1016/j.arr.2017.08.005},
  pmid    = {28941639},
  url     = {https://doi.org/10.1016/j.arr.2017.08.005}
}

@article{bolos2017-28231054,
  author  = {Bolós, M. and Perea, JR. and Avila, J.},
  title   = {{Alzheimer's disease as an inflammatory disease}},
  journal = {Biomolecular concepts},
  year    = {2017},
  doi     = {10.1515/bmc-2016-0029},
  pmid    = {28231054},
  url     = {https://doi.org/10.1515/bmc-2016-0029}
}

@article{du2017-27206432,
  author  = {Du, S. Q. and Wang, X. R. and Xiao, L. Y. and Tu, J. F. and Zhu, W. and He, T. and Liu, C. Z.},
  title   = {{Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?}},
  journal = {Molecular neurobiology},
  year    = {2017},
  doi     = {10.1007/s12035-016-9915-1},
  pmid    = {27206432},
  url     = {https://doi.org/10.1007/s12035-016-9915-1}
}

@article{mcgeer2006-16914866,
  author  = {McGeer, P. L. and Rogers, J. and McGeer, E. G.},
  title   = {{Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2006},
  doi     = {10.3233/jad-2006-9s330},
  pmid    = {16914866},
  url     = {https://doi.org/10.3233/jad-2006-9s330}
}

@article{yasuno2008-18514164,
  author  = {Yasuno, F. and Ota, M. and Kosaka, J. and Ito, H. and Higuchi, M. and Doronbekov, T. K. and Nozaki, S. and Fujimura, Y. and others},
  title   = {{Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106}},
  journal = {Biological psychiatry},
  year    = {2008},
  doi     = {10.1016/j.biopsych.2008.04.021},
  pmid    = {18514164},
  url     = {https://doi.org/10.1016/j.biopsych.2008.04.021}
}

@article{miao2005-16049335,
  author  = {Miao, J. and Xu, F. and Davis, J. and Otte-Höller, I. and Verbeek, M. M. and Van Nostrand, W. E.},
  title   = {{Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein}},
  journal = {The American journal of pathology},
  year    = {2005},
  doi     = {10.1016/s0002-9440(10)62993-8},
  pmid    = {16049335},
  url     = {https://doi.org/10.1016/s0002-9440(10)62993-8}
}

@article{ye2025-39806423,
  author  = {Ye, Jinwang and Zhong, Suyue and Wan, Huali and Guo, Xing and Yao, Xuanbao and Liu, Qiong and Chen, Liming and Wang, Jian‐Zhi and others},
  title   = {{Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00796-2},
  pmid    = {39806423},
  url     = {https://doi.org/10.1186/s13024-025-00796-2}
}

@article{leng2025-40951922,
  author  = {Leng, Kun and Maze, Mervyn and Chang, Odmara L. Barreto},
  title   = {{Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1632947},
  pmid    = {40951922},
  url     = {https://doi.org/10.3389/fnagi.2025.1632947}
}

@article{cacerespalomo2025-41388301,
  author  = {Cáceres-Palomo, Laura and Sánchez‐Mejías, Elisabeth and Trujillo‐Estrada, Laura and Pérez-Moreno, Juan José and Lopez-Oliva, Elba and Lim, Tau En and DeFlitch, Leah and Chang, Serena H. and others},
  title   = {{Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03607-z},
  pmid    = {41388301},
  url     = {https://doi.org/10.1186/s12974-025-03607-z}
}

@article{dagla2026-41677657,
  author  = {Dagla, Ioanna and Gkikas, Faidon and Gikas, Evagelos and Tsarbopoulos, Anthony},
  title   = {{Targeting Amyloid Beta Aggregation and Neuroinflammation in Alzheimer’s Disease: Advances and Future Directions}},
  journal = {Cells},
  year    = {2026},
  doi     = {10.3390/cells15030295},
  pmid    = {41677657},
  url     = {https://doi.org/10.3390/cells15030295}
}

@article{torre2025-39863251,
  author  = {Torre, Matthew and Zanella, Camila A. and Feany, Mel Β.},
  title   = {{The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and Alzheimer Disease}},
  journal = {American Journal Of Pathology},
  year    = {2025},
  doi     = {10.1016/j.ajpath.2024.12.013},
  pmid    = {39863251},
  url     = {https://doi.org/10.1016/j.ajpath.2024.12.013}
}

@article{domingo2026-42497677,
  author  = {Domingo, J. L. and Colomina, M. T.},
  title   = {{Aluminum and Alzheimer's disease in the 21st century: An umbrella review of evidence and controversies}},
  journal = {Neurotoxicology},
  year    = {2026},
  doi     = {10.1016/j.neuro.2026.103531},
  pmid    = {42497677},
  url     = {https://doi.org/10.1016/j.neuro.2026.103531}
}

@article{tyagi2026-41510854,
  author  = {Tyagi, S. and Murali, N. and Singh, S. K. and Babtiwale, SR. and Padhi, B. K. and Lakshmi, N. R. A. and Gandhi, A. P.},
  title   = {{A Systematic Review to Evaluate the Effect of Neflamapimod on Cognitive Function and Progression of Dementia}},
  journal = {Neurology India},
  year    = {2026},
  doi     = {10.4103/neurol-india.neurol-india-d-25-00227},
  pmid    = {41510854},
  url     = {https://doi.org/10.4103/neurol-india.neurol-india-d-25-00227}
}

@article{gu2025-41137028,
  author  = {Gu, Q. and Wang, S. and Zhu, L. and Sun, Q. and Zhang, Y.},
  title   = {{Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: a meta-analysis}},
  journal = {AIDS research and therapy},
  year    = {2025},
  doi     = {10.1186/s12981-025-00804-x},
  pmid    = {41137028},
  url     = {https://doi.org/10.1186/s12981-025-00804-x}
}

@article{petersvanton2020-32592865,
  author  = {Peters van Ton, A. M. and Verbeek, M. M. and Alkema, W. and Pickkers, P. and Abdo, W. F.},
  title   = {{Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer's disease}},
  journal = {Brain, behavior, and immunity},
  year    = {2020},
  doi     = {10.1016/j.bbi.2020.06.027},
  pmid    = {32592865},
  url     = {https://doi.org/10.1016/j.bbi.2020.06.027}
}

@article{thomas1992-1638276,
  author  = {Thomas, W. E.},
  title   = {{Brain macrophages: evaluation of microglia and their functions}},
  journal = {Brain research. Brain research reviews},
  year    = {1992},
  doi     = {10.1016/0165-0173(92)90007-9},
  pmid    = {1638276},
  url     = {https://doi.org/10.1016/0165-0173(92)90007-9}
}

@article{saha2006-16771683,
  author  = {Saha, R. N. and Pahan, K.},
  title   = {{Regulation of inducible nitric oxide synthase gene in glial cells}},
  journal = {Antioxidants \& redox signaling},
  year    = {2006},
  doi     = {10.1089/ars.2006.8.929},
  pmid    = {16771683},
  url     = {https://doi.org/10.1089/ars.2006.8.929}
}

@article{lee2010-21052932,
  author  = {Lee, Y. J. and Han, S. B. and Nam, S. Y. and Oh, K. W. and Hong, J. T.},
  title   = {{Inflammation and Alzheimer's disease}},
  journal = {Archives of pharmacal research},
  year    = {2010},
  doi     = {10.1007/s12272-010-1006-7},
  pmid    = {21052932},
  url     = {https://doi.org/10.1007/s12272-010-1006-7}
}

@article{mishra2008-19966973,
  author  = {Mishra, S. and Palanivelu, K.},
  title   = {{The effect of curcumin (turmeric) on Alzheimer's disease: An overview}},
  journal = {Annals of Indian Academy of Neurology},
  year    = {2008},
  doi     = {10.4103/0972-2327.40220},
  pmid    = {19966973},
  url     = {https://doi.org/10.4103/0972-2327.40220}
}

@article{bajetto2001-11456467,
  author  = {Bajetto, A. and Bonavia, R. and Barbero, S. and Florio, T. and Schettini, G.},
  title   = {{Chemokines and their receptors in the central nervous system}},
  journal = {Frontiers in neuroendocrinology},
  year    = {2001},
  doi     = {10.1006/frne.2001.0214},
  pmid    = {11456467},
  url     = {https://doi.org/10.1006/frne.2001.0214}
}

@article{lee2008-18492487,
  author  = {Lee, H. J. and Suk, J. E. and Bae, E. J. and Lee, S. J.},
  title   = {{Clearance and deposition of extracellular alpha-synuclein aggregates in microglia}},
  journal = {Biochemical and biophysical research communications},
  year    = {2008},
  doi     = {10.1016/j.bbrc.2008.05.045},
  pmid    = {18492487},
  url     = {https://doi.org/10.1016/j.bbrc.2008.05.045}
}

@article{johnstone1999-10378882,
  author  = {Johnstone, M. and Gearing, A. J. and Miller, K. M.},
  title   = {{A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced}},
  journal = {Journal of neuroimmunology},
  year    = {1999},
  doi     = {10.1016/s0165-5728(98)00226-4},
  pmid    = {10378882},
  url     = {https://doi.org/10.1016/s0165-5728(98)00226-4}
}

@article{maezawa2011-20971854,
  author  = {Maezawa, I. and Zimin, P. I. and Wulff, H. and Jin, L. W.},
  title   = {{Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.135244},
  pmid    = {20971854},
  url     = {https://doi.org/10.1074/jbc.m110.135244}
}

@article{persidsky1997-9120312,
  author  = {Persidsky, Y. and Stins, M. and Way, D. and Witte, M. H. and Weinand, M. and Kim, K. S. and Bock, P. and Gendelman, H. E. and others},
  title   = {{A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {1997},
  doi     = {10.4049/jimmunol.158.7.3499},
  pmid    = {9120312},
  url     = {https://doi.org/10.4049/jimmunol.158.7.3499}
}

@article{walker2019-31241312,
  author  = {Walker, K. A. and Ficek, B. N. and Westbrook, R.},
  title   = {{Understanding the Role of Systemic Inflammation in Alzheimer's Disease}},
  journal = {ACS chemical neuroscience},
  year    = {2019},
  doi     = {10.1021/acschemneuro.9b00333},
  pmid    = {31241312},
  url     = {https://doi.org/10.1021/acschemneuro.9b00333}
}

@article{hong2016-27230456,
  author  = {Hong, H. and Kim, B. S. and Im, H. I.},
  title   = {{Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders}},
  journal = {International neurourology journal},
  year    = {2016},
  doi     = {10.5213/inj.1632604.302},
  pmid    = {27230456},
  url     = {https://doi.org/10.5213/inj.1632604.302}
}

@article{wang2017-28318352,
  author  = {Wang, D. and Zhang, J. and Jiang, W. and Cao, Z. and Zhao, F. and Cai, T. and Aschner, M. and Luo, W.},
  title   = {{The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability}},
  journal = {Autophagy},
  year    = {2017},
  doi     = {10.1080/15548627.2017.1293766},
  pmid    = {28318352},
  url     = {https://doi.org/10.1080/15548627.2017.1293766}
}

@article{doorn2014-25099483,
  author  = {Doorn, K. J. and Moors, T. and Drukarch, B. and WDj, van de Berg and Lucassen, P. J. and van Dam, A. M.},
  title   = {{Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients}},
  journal = {Acta neuropathologica communications},
  year    = {2014},
  doi     = {10.1186/s40478-014-0090-1},
  pmid    = {25099483},
  url     = {https://doi.org/10.1186/s40478-014-0090-1}
}

@article{wang2020-33015803,
  author  = {Wang, X. X. and Zhang, B. and Xia, R. and Jia, Q. Y.},
  title   = {{Inflammation, apoptosis and autophagy as critical players in vascular dementia}},
  journal = {European review for medical and pharmacological sciences},
  year    = {2020},
  doi     = {10.26355/eurrev_202009_23048},
  pmid    = {33015803},
  url     = {https://doi.org/10.26355/eurrev_202009_23048}
}

@article{faden2015-25421001,
  author  = {Faden, A. I. and Loane, D. J.},
  title   = {{Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2015},
  doi     = {10.1007/s13311-014-0319-5},
  pmid    = {25421001},
  url     = {https://doi.org/10.1007/s13311-014-0319-5}
}

@article{perlmutter1990-2097581,
  author  = {Perlmutter, L. S. and Barron, E. and Chui, H. C.},
  title   = {{Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease}},
  journal = {Neuroscience letters},
  year    = {1990},
  doi     = {10.1016/0304-3940(90)90748-x},
  pmid    = {2097581},
  url     = {https://doi.org/10.1016/0304-3940(90)90748-x}
}

@article{schmidtmayerova1996-8570619,
  author  = {Schmidtmayerova, H. and Nottet, H. S. and Nuovo, G. and Raabe, T. and Flanagan, C. R. and Dubrovsky, L. and Gendelman, H. E. and Cerami, A. and others},
  title   = {{Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1996},
  doi     = {10.1073/pnas.93.2.700},
  pmid    = {8570619},
  url     = {https://doi.org/10.1073/pnas.93.2.700}
}

@article{hannestad2012-22776451,
  author  = {Hannestad, J. and Gallezot, J. D. and Schafbauer, T. and Lim, K. and Kloczynski, T. and Morris, E. D. and Carson, R. E. and Ding, Y. S. and others},
  title   = {{Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates}},
  journal = {NeuroImage},
  year    = {2012},
  doi     = {10.1016/j.neuroimage.2012.06.055},
  pmid    = {22776451},
  url     = {https://doi.org/10.1016/j.neuroimage.2012.06.055}
}

@article{schwab2008-18487845,
  author  = {Schwab, C. and McGeer, P. L.},
  title   = {{Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2008},
  doi     = {10.3233/jad-2008-13402},
  pmid    = {18487845},
  url     = {https://doi.org/10.3233/jad-2008-13402}
}

@article{afagh1996-8593893,
  author  = {Afagh, A. and Cummings, B. J. and Cribbs, D. H. and Cotman, C. W. and Tenner, A. J.},
  title   = {{Localization and cell association of C1q in Alzheimer's disease brain}},
  journal = {Experimental neurology},
  year    = {1996},
  doi     = {10.1006/exnr.1996.0043},
  pmid    = {8593893},
  url     = {https://doi.org/10.1006/exnr.1996.0043}
}

@article{lee2009-19631409,
  author  = {Lee, M. and Schwab, C. and Yu, S. and McGeer, E. and McGeer, P. L.},
  title   = {{Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide}},
  journal = {Neurobiology of aging},
  year    = {2009},
  doi     = {10.1016/j.neurobiolaging.2009.06.001},
  pmid    = {19631409},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2009.06.001}
}

@article{giulian1995-7655344,
  author  = {Giulian, D. and Haverkamp, L. J. and Li, J. and Karshin, W. L. and Yu, J. and Tom, D. and Li, X. and Kirkpatrick, J. B.},
  title   = {{Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain}},
  journal = {Neurochemistry international},
  year    = {1995},
  doi     = {10.1016/0197-0186(95)00067-i},
  pmid    = {7655344},
  url     = {https://doi.org/10.1016/0197-0186(95)00067-i}
}

@article{igarashi2011-21297269,
  author  = {Igarashi, M. and Ma, K. and Gao, F. and Kim, H. W. and Rapoport, S. I. and Rao, J. S.},
  title   = {{Disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2011},
  doi     = {10.3233/jad-2011-101608},
  pmid    = {21297269},
  url     = {https://doi.org/10.3233/jad-2011-101608}
}

@article{yin2010-20667979,
  author  = {Yin, F. and Dumont, M. and Banerjee, R. and Ma, Y. and Li, H. and Lin, M. T. and Beal, M. F. and Nathan, C. and others},
  title   = {{Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2010},
  doi     = {10.1096/fj.10-161471},
  pmid    = {20667979},
  url     = {https://doi.org/10.1096/fj.10-161471}
}

@article{akiguchi2017-28261874,
  author  = {Akiguchi, I. and Pallàs, M. and Budka, H. and Akiyama, H. and Ueno, M. and Han, J. and Yagi, H. and Nishikawa, T. and others},
  title   = {{SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions}},
  journal = {Neuropathology : official journal of the Japanese Society of Neuropathology},
  year    = {2017},
  doi     = {10.1111/neup.12373},
  pmid    = {28261874},
  url     = {https://doi.org/10.1111/neup.12373}
}

@article{cortescanteli2015-25475538,
  author  = {Cortes-Canteli, M. and Mattei, L. and Richards, A. T. and Norris, E. H. and Strickland, S.},
  title   = {{Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2014.10.030},
  pmid    = {25475538},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.10.030}
}

@article{rosenberg2017-28265034,
  author  = {Rosenberg, G. A.},
  title   = {{Extracellular matrix inflammation in vascular cognitive impairment and dementia}},
  journal = {Clinical science (London, England : 1979)},
  year    = {2017},
  doi     = {10.1042/cs20160604},
  pmid    = {28265034},
  url     = {https://doi.org/10.1042/cs20160604}
}

@article{parachikova2008-18258444,
  author  = {Parachikova, A. and Nichol, K. E. and Cotman, C. W.},
  title   = {{Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition}},
  journal = {Neurobiology of disease},
  year    = {2008},
  doi     = {10.1016/j.nbd.2007.12.008},
  pmid    = {18258444},
  url     = {https://doi.org/10.1016/j.nbd.2007.12.008}
}

@article{tweedie2007-17908040,
  author  = {Tweedie, D. and Sambamurti, K. and Greig, N. H.},
  title   = {{TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets}},
  journal = {Current Alzheimer research},
  year    = {2007},
  doi     = {10.2174/156720507781788873},
  pmid    = {17908040},
  url     = {https://doi.org/10.2174/156720507781788873}
}

@article{miller2025-40279247,
  author  = {Miller, Cameron R. and Ealy, Alyssa and Gregory, Amanda and Janarthanam, Chelva and Albers, William G and Richardson, Gabriel and Jin, Huajun and Zenitsky, Gary D. and others},
  title   = {{Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia}},
  journal = {Cell Reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.115618},
  pmid    = {40279247},
  url     = {https://doi.org/10.1016/j.celrep.2025.115618}
}

@article{labarbera2025-41077614,
  author  = {La Barbera, Livia and Krashia, Paraskevi and Loffredo, Gilda and Cauzzi, Emma and De Paolis, Maria Luisa and Montanari, Martina and Saba, Luana and Spoleti, Elena and others},
  title   = {{Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00893-2},
  pmid    = {41077614},
  url     = {https://doi.org/10.1186/s13024-025-00893-2}
}

@article{dilorenzo2025-40869114,
  author  = {Di Lorenzo, Rosa and Zecca, Chiara and Chimienti, Guglielmina and Latronico, Tiziana and Liuzzi, Grazia Maria and Pesce, Vito and Dell’Abate, Maria Teresa and Borlizzi, Francesco and others},
  title   = {{Reliable New Biomarkers of Mitochondrial Oxidative Stress and Neuroinflammation in Cerebrospinal Fluid and Plasma from Alzheimer’s Disease Patients: A Pilot Study}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26167792},
  pmid    = {40869114},
  url     = {https://doi.org/10.3390/ijms26167792}
}

@article{ihuoma2026-41831270,
  author  = {Ihuoma, Jennifer and Milan, Madison and Negri, Sharon and Troyano‐Rodriguez, Eva and Rudraboina, Rakesh and Kosmider, Aleksandra and Awasthi, Shantipriya and Csiszar, Anna and others},
  title   = {{LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia}},
  journal = {Redox Biology},
  year    = {2026},
  doi     = {10.1016/j.redox.2026.104118},
  pmid    = {41831270},
  url     = {https://doi.org/10.1016/j.redox.2026.104118}
}

@article{arbaciauskaite2026-41678018,
  author  = {Arbaciauskaite, Skaiste and Silvestri, Simona and Luo, Pingyan and Krüger, Christina and Mossmann, Zoé J. and Allelein, Susann and Scholz, Alexander and Löffler, Dennis and others},
  title   = {{Microglia-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Carry miRNAs Driving a Neuroinflammatory Response}},
  journal = {Molecular Neurobiology},
  year    = {2026},
  doi     = {10.1007/s12035-026-05719-w},
  pmid    = {41678018},
  url     = {https://doi.org/10.1007/s12035-026-05719-w}
}

@article{hauer2025-40885039,
  author  = {Hauer, Kevin Oliveira and Hall, Sara and Nahimi, Adjmal and Strandberg, Olof T. and Ohlsson, Tomas G. and Jögi, Jonas and Stomrud, Erik and Janelidze, Shorena and others},
  title   = {{CSF markers of neuroinflammation, synaptic dysfunction and [18F]DOPA-PET in Parkinson's disease}},
  journal = {Parkinsonism \& Related Disorders},
  year    = {2025},
  doi     = {10.1016/j.parkreldis.2025.108005},
  pmid    = {40885039},
  url     = {https://doi.org/10.1016/j.parkreldis.2025.108005}
}

@article{peng2025-41001154,
  author  = {Peng, Y. and Chen, H. and Peng, K. and Li, L. and Ma, Z.},
  title   = {{Mapping the research landscape of Mild Cognitive Impairment in Parkinson's disease: a bibliometric and visualization analysis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1624420},
  pmid    = {41001154},
  url     = {https://doi.org/10.3389/fnagi.2025.1624420}
}

@article{choi2011-21463871,
  author  = {Choi, J. and Lee, H. W. and Suk, K.},
  title   = {{Increased plasma levels of lipocalin 2 in mild cognitive impairment}},
  journal = {Journal of the neurological sciences},
  year    = {2011},
  doi     = {10.1016/j.jns.2011.03.023},
  pmid    = {21463871},
  url     = {https://doi.org/10.1016/j.jns.2011.03.023}
}

@article{seilhean1997-9144590,
  author  = {Seilhean, D. and Kobayashi, K. and He, Y. and Uchihara, T. and Rosenblum, O. and Katlama, C. and Bricaire, F. and Duyckaerts, C. and others},
  title   = {{Tumor necrosis factor-alpha, microglia and astrocytes in AIDS dementia complex}},
  journal = {Acta neuropathologica},
  year    = {1997},
  doi     = {10.1007/s004010050646},
  pmid    = {9144590},
  url     = {https://doi.org/10.1007/s004010050646}
}

@article{price2021-33812051,
  author  = {Price, B. R. and Johnson, L. A. and Norris, C. M.},
  title   = {{Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer's disease}},
  journal = {Ageing research reviews},
  year    = {2021},
  doi     = {10.1016/j.arr.2021.101335},
  pmid    = {33812051},
  url     = {https://doi.org/10.1016/j.arr.2021.101335}
}

@article{shabbir2021-33669988,
  author  = {Shabbir, U. and Arshad, M. S. and Sameen, A. and Oh, D. H.},
  title   = {{Crosstalk between Gut and Brain in Alzheimer's Disease: The Role of Gut Microbiota Modulation Strategies}},
  journal = {Nutrients},
  year    = {2021},
  doi     = {10.3390/nu13020690},
  pmid    = {33669988},
  url     = {https://doi.org/10.3390/nu13020690}
}

@article{candelariojalil2011-21454822,
  author  = {Candelario-Jalil, E. and Thompson, J. and Taheri, S. and Grossetete, M. and Adair, J. C. and Edmonds, E. and Prestopnik, J. and Wills, J. and others},
  title   = {{Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment}},
  journal = {Stroke},
  year    = {2011},
  doi     = {10.1161/strokeaha.110.600825},
  pmid    = {21454822},
  url     = {https://doi.org/10.1161/strokeaha.110.600825}
}

@article{chen2016-26667280,
  author  = {Chen, A. and Akinyemi, R. O. and Hase, Y. and Firbank, M. J. and Ndung'u, M. N. and Foster, V. and Craggs, L. J. and Washida, K. and others},
  title   = {{Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia}},
  journal = {Brain : a journal of neurology},
  year    = {2016},
  doi     = {10.1093/brain/awv328},
  pmid    = {26667280},
  url     = {https://doi.org/10.1093/brain/awv328}
}

@article{liu2014-24667364,
  author  = {Liu, Y. and Fu, X. and Lan, N. and Li, S. and Zhang, J. and Wang, S. and Li, C. and Shang, Y. and others},
  title   = {{Luteolin protects against high fat diet-induced cognitive deficits in obesity mice}},
  journal = {Behavioural brain research},
  year    = {2014},
  doi     = {10.1016/j.bbr.2014.02.040},
  pmid    = {24667364},
  url     = {https://doi.org/10.1016/j.bbr.2014.02.040}
}

@article{feng2023-37351177,
  author  = {Feng, S. and Wu, C. and Zou, P. and Deng, Q. and Chen, Z. and Li, M. and Zhu, L. and Li, F. and others},
  title   = {{High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization}},
  journal = {Theranostics},
  year    = {2023},
  doi     = {10.7150/thno.81951},
  pmid    = {37351177},
  url     = {https://doi.org/10.7150/thno.81951}
}

@article{zhou2021-34108016,
  author  = {Zhou, Y. and Xu, J. and Hou, Y. and Leverenz, J. B. and Kallianpur, A. and Mehra, R. and Liu, Y. and Yu, H. and others},
  title   = {{Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00850-3},
  pmid    = {34108016},
  url     = {https://doi.org/10.1186/s13195-021-00850-3}
}

@article{zhou2023-36989373,
  author  = {Zhou, J. and Wade, S. D. and Graykowski, D. and Xiao, M. F. and Zhao, B. and Giannini, L. A. A. and Hanson, J. E. and van Swieten, J. C. and others},
  title   = {{The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration}},
  journal = {Science translational medicine},
  year    = {2023},
  doi     = {10.1126/scitranslmed.adf0141},
  pmid    = {36989373},
  url     = {https://doi.org/10.1126/scitranslmed.adf0141}
}

@article{salter2017-28886007,
  author  = {Salter, M. W. and Stevens, B.},
  title   = {{Microglia emerge as central players in brain disease}},
  journal = {Nature medicine},
  year    = {2017},
  doi     = {10.1038/nm.4397},
  pmid    = {28886007},
  url     = {https://doi.org/10.1038/nm.4397}
}

@article{zhang2023-37433768,
  author  = {Zhang, W. and Xiao, D. and Mao, Q. and Xia, H.},
  title   = {{Role of neuroinflammation in neurodegeneration development}},
  journal = {Signal transduction and targeted therapy},
  year    = {2023},
  doi     = {10.1038/s41392-023-01486-5},
  pmid    = {37433768},
  url     = {https://doi.org/10.1038/s41392-023-01486-5}
}

@article{teleanu2022-35682615,
  author  = {Teleanu, D. M. and Niculescu, A. G. and Lungu, II. and Radu, C. I. and Vladâcenco, O. and Roza, E. and Costăchescu, B. and Grumezescu, A. M. and others},
  title   = {{An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23115938},
  pmid    = {35682615},
  url     = {https://doi.org/10.3390/ijms23115938}
}

@article{guo2022-35250543,
  author  = {Guo, S. and Wang, H. and Yin, Y.},
  title   = {{Microglia Polarization From M1 to M2 in Neurodegenerative Diseases}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.815347},
  pmid    = {35250543},
  url     = {https://doi.org/10.3389/fnagi.2022.815347}
}

@article{nott2019-31727856,
  author  = {Nott, A. and Holtman, I. R. and Coufal, N. G. and Schlachetzki, J. C. M. and Yu, M. and Hu, R. and Han, C. Z. and Pena, M. and others},
  title   = {{Brain cell type-specific enhancer-promoter interactome maps and disease - risk association}},
  journal = {Science (New York, N.Y.)},
  year    = {2019},
  doi     = {10.1126/science.aay0793},
  pmid    = {31727856},
  url     = {https://doi.org/10.1126/science.aay0793}
}

@article{alkhayri2022-35566252,
  author  = {Al-Khayri, J. M. and Sahana, G. R. and Nagella, P. and Joseph, B. V. and Alessa, F. M. and Al-Mssallem, M. Q.},
  title   = {{Flavonoids as Potential Anti-Inflammatory Molecules: A Review}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2022},
  doi     = {10.3390/molecules27092901},
  pmid    = {35566252},
  url     = {https://doi.org/10.3390/molecules27092901}
}

@article{xu2025-40075143,
  author  = {Xu, Wen and Huang, Yi and Zhou, Rongbin},
  title   = {{NLRP3 inflammasome in neuroinflammation and central nervous system diseases}},
  journal = {Cellular \& molecular immunology},
  year    = {2025},
  doi     = {10.1038/s41423-025-01275-w},
  pmid    = {40075143},
  url     = {https://doi.org/10.1038/s41423-025-01275-w}
}

@article{li2025-40260242,
  author  = {Li, Zhitao and Gong, Chunrong},
  title   = {{NLRP3 inflammasome in Alzheimer's disease: molecular mechanisms and emerging therapies}},
  journal = {Frontiers in immunology},
  year    = {2025},
  doi     = {10.3389/fimmu.2025.1583886},
  pmid    = {40260242},
  url     = {https://doi.org/10.3389/fimmu.2025.1583886}
}

@article{verma2024-38507186,
  author  = {Verma, Ambika and Azhar, Gohar and Patyal, Pankaj and Zhang, Wei and Zhang, Xiaomin and Wei, Jeanne Y},
  title   = {{Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells}},
  journal = {GeroScience},
  year    = {2024},
  doi     = {10.1007/s11357-024-01117-z},
  pmid    = {38507186},
  url     = {https://doi.org/10.1007/s11357-024-01117-z}
}

@article{arcosencarnacion2025-40537787,
  author  = {Arcos-Encarnación, Bolivar and Cortes-Flores, Eladio and Barón-Mendoza, Isabel and Almazán, Jorge Luis and Valle-García, David and de León-Guerrero, Sol Díaz and Hovan, Ladislav and Meza-Sosa, Karla F and others},
  title   = {{KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03426-2},
  pmid    = {40537787},
  url     = {https://doi.org/10.1186/s12974-025-03426-2}
}

@article{wang2025-40847374,
  author  = {Wang, Jie and Ni, Hong and Wang, Yu and Wei, Luyao and Ding, Hanqing and Guo, Zhongzhao and Pan, Hao and Yu, Ying and others},
  title   = {{Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00501-9},
  pmid    = {40847374},
  url     = {https://doi.org/10.1186/s40035-025-00501-9}
}

@article{leibold2024-38663120,
  author  = {Leibold, Noah S and Despa, Florin},
  title   = {{Neuroinflammation induced by amyloid-forming pancreatic amylin: Rationale for a mechanistic hypothesis}},
  journal = {Biophysical chemistry},
  year    = {2024},
  doi     = {10.1016/j.bpc.2024.107252},
  pmid    = {38663120},
  url     = {https://doi.org/10.1016/j.bpc.2024.107252}
}

@article{guo2025-40541122,
  author  = {Guo, Minsong and Wang, Zhengqin and Zhou, Xiaogang and Yu, Chonglin and Wu, Jianming and Yu, Lu and Mi, Jianing and Ren, Fang and others},
  title   = {{Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.156928},
  pmid    = {40541122},
  url     = {https://doi.org/10.1016/j.phymed.2025.156928}
}

@article{vilella2024-37967665,
  author  = {Vilella, Antonietta and Bodria, Martina and Papotti, Bianca and Zanotti, Ilaria and Zimetti, Francesca and Remaggi, Giulia and Elviri, Lisa and Potì, Francesco and others},
  title   = {{PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2024},
  doi     = {10.1016/j.bbi.2023.11.008},
  pmid    = {37967665},
  url     = {https://doi.org/10.1016/j.bbi.2023.11.008}
}

@article{xu2025-41175591,
  author  = {Xu, Ziwei and Huang, Feijun and Wu, Zheming and Xu, Ke and Huang, Liping},
  title   = {{Syringin attenuates Alzheimer's disease-associated neuroinflammation by inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.157454},
  pmid    = {41175591},
  url     = {https://doi.org/10.1016/j.phymed.2025.157454}
}

@article{joshi2024-39215356,
  author  = {Joshi, Radhika and Brezani, Veronika and Mey, Gabrielle M and Guixé-Muntet, Sergi and Ortega-Ribera, Marti and Zhuang, Yuan and Zivny, Adam and Werneburg, Sebastian and others},
  title   = {{IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2024},
  doi     = {10.1186/s12974-024-03203-7},
  pmid    = {39215356},
  url     = {https://doi.org/10.1186/s12974-024-03203-7}
}

@article{li2024-38043010,
  author  = {Li, Yunfeng and Chen, Xiongjin and Zhou, Mulan and Feng, Sifan and Peng, Xiaoping and Wang, Yan},
  title   = {{Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-230273},
  pmid    = {38043010},
  url     = {https://doi.org/10.3233/jad-230273}
}

@article{firdous2024-38832985,
  author  = {Firdous, Sayed Mohammed and Khan, Sahabaj Ali and Maity, Amritangshu},
  title   = {{Oxidative stress-mediated neuroinflammation in Alzheimer's disease}},
  journal = {Naunyn-Schmiedeberg's archives of pharmacology},
  year    = {2024},
  doi     = {10.1007/s00210-024-03188-3},
  pmid    = {38832985},
  url     = {https://doi.org/10.1007/s00210-024-03188-3}
}

@article{qin2024-38577947,
  author  = {Qin, Pei and Sun, Ye and Li, Liya},
  title   = {{Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)}},
  journal = {International journal of molecular medicine},
  year    = {2024},
  doi     = {10.3892/ijmm.2024.5371},
  pmid    = {38577947},
  url     = {https://doi.org/10.3892/ijmm.2024.5371}
}

@article{paesmans2024-39381137,
  author  = {Paesmans, Ine and Van Kolen, Kristof and Vandermeeren, Marc and Shih, Pei-Yu and Wuyts, Dirk and Boone, Fleur and Sanchez, Sergio Garcia and Grauwen, Karolien and others},
  title   = {{NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology}},
  journal = {Frontiers in aging neuroscience},
  year    = {2024},
  doi     = {10.3389/fnagi.2024.1459134},
  pmid    = {39381137},
  url     = {https://doi.org/10.3389/fnagi.2024.1459134}
}

@article{ravichandran2025-41206011,
  author  = {Ravichandran, Kishore Aravind and Brosseron, Frederic and McManus, Róisín M and Ising, Christina and Görgen, Simon and Schmidt, Susanne V and Santarelli, Fracesco and Lee, Se Young and others},
  title   = {{Enhancing Tyro3 signaling ameliorates IL-1β production through STAT1 in Alzheimer's disease models}},
  journal = {Journal of leukocyte biology},
  year    = {2025},
  doi     = {10.1093/jleuko/qiaf157},
  pmid    = {41206011},
  url     = {https://doi.org/10.1093/jleuko/qiaf157}
}

@article{han2025-40400619,
  author  = {Han, Jialin and Zhang, Zhi and Zhang, Pengfei and Yu, Qian and Cheng, Qian and Lu, Zhiming and Zong, Shuai},
  title   = {{The roles of microglia and astrocytes in neuroinflammation of Alzheimer's disease}},
  journal = {Frontiers in neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1575453},
  pmid    = {40400619},
  url     = {https://doi.org/10.3389/fnins.2025.1575453}
}

@article{serradas2024-39272998,
  author  = {Serradas, Maria L and Ding, Yingying and Martorell, Paula V and Kulińska, Ida and Castro-Gomez, Sergio},
  title   = {{Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease}},
  journal = {Cells},
  year    = {2024},
  doi     = {10.3390/cells13171426},
  pmid    = {39272998},
  url     = {https://doi.org/10.3390/cells13171426}
}

@article{zubillaga2025-40992081,
  author  = {Zubillaga, Marlene and Abadin, Xenia and Ivars, Elia and Puigròs, Margalida and Trullas, Ramon and Bellini, M José and Arnal, Nathalie and Colell, Anna},
  title   = {{Copper overload worsens the inflammatory response of microglia to amyloid beta (Aβ) by impairing phagocytosis and promoting mitochondrial DNA-mediated NLRP3 inflammasome activation}},
  journal = {Redox biology},
  year    = {2025},
  doi     = {10.1016/j.redox.2025.103872},
  pmid    = {40992081},
  url     = {https://doi.org/10.1016/j.redox.2025.103872}
}

@article{braatz2024-36799439,
  author  = {Braatz, Charlotte and Komes, Max P and Ravichandran, Kishore Aravind and de Fragas, Matheus Garcia and Griep, Angelika and Schwartz, Stephanie and McManus, Róisín M and Heneka, Michael T},
  title   = {{NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro}},
  journal = {Journal of neurochemistry},
  year    = {2024},
  doi     = {10.1111/jnc.15778},
  pmid    = {36799439},
  url     = {https://doi.org/10.1111/jnc.15778}
}

@article{wang2025-41062518,
  author  = {Wang, Xiaoxuan and Tian, Haozhe and Chen, Shifei and Ying, Liangliang and Zheng, Juan and Song, Yaya and Xi, Jin and Zhang, Yuxin and others},
  title   = {{Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells}},
  journal = {Scientific reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-19015-5},
  pmid    = {41062518},
  url     = {https://doi.org/10.1038/s41598-025-19015-5}
}

@article{zhang2021-34239348,
  author  = {Zhang, Huiqin and Wei, Wei and Zhao, Ming and Ma, Lina and Jiang, Xuefan and Pei, Hui and Cao, Yu and Li, Hao},
  title   = {{Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease}},
  journal = {International Journal of Biological Sciences},
  year    = {2021},
  doi     = {10.7150/ijbs.57078},
  pmid    = {34239348},
  url     = {https://doi.org/10.7150/ijbs.57078}
}

@article{maphis2015-25833819,
  author  = {Maphis, Nicole M. and Xu, Guixiang and Kokiko‐Cochran, Olga N. and Jiang, Shanya and Cardona, Astrid E. and Ransohoff, Richard M. and Lamb, Bruce T. and Bhaskar, Kiran},
  title   = {{Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain}},
  journal = {Brain},
  year    = {2015},
  doi     = {10.1093/brain/awv081},
  pmid    = {25833819},
  url     = {https://doi.org/10.1093/brain/awv081}
}

@article{saura1994-7816197,
  author  = {Saura, J. and Luque, J. M. and Cesura, A. M. and Da Prada, M. and Chan-Palay, V. and Huber, G. and Löffler, J. and Richards, J. G.},
  title   = {{Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography}},
  journal = {Neuroscience},
  year    = {1994},
  doi     = {10.1016/0306-4522(94)90311-5},
  pmid    = {7816197},
  url     = {https://doi.org/10.1016/0306-4522(94)90311-5}
}

@article{flanary2007-17378753,
  author  = {Flanary, B. E. and Sammons, N. W. and Nguyen, C. and Walker, D. and Streit, W. J.},
  title   = {{Evidence that aging and amyloid promote microglial cell senescence}},
  journal = {Rejuvenation research},
  year    = {2007},
  doi     = {10.1089/rej.2006.9096},
  pmid    = {17378753},
  url     = {https://doi.org/10.1089/rej.2006.9096}
}

@article{wenk2003-12934968,
  author  = {Wenk, G. L.},
  title   = {{Neuropathologic changes in Alzheimer's disease}},
  journal = {The Journal of clinical psychiatry},
  year    = {2003},
  pmid    = {12934968}
}

@article{ranki1995-8527071,
  author  = {Ranki, A. and Nyberg, M. and Ovod, V. and Haltia, M. and Elovaara, I. and Raininko, R. and Haapasalo, H. and Krohn, K.},
  title   = {{Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia}},
  journal = {AIDS (London, England)},
  year    = {1995},
  doi     = {10.1097/00002030-199509000-00004},
  pmid    = {8527071},
  url     = {https://doi.org/10.1097/00002030-199509000-00004}
}

@article{schwartz2016-27616557,
  author  = {Schwartz, M. and Deczkowska, A.},
  title   = {{Neurological Disease as a Failure of Brain-Immune Crosstalk: The Multiple Faces of Neuroinflammation}},
  journal = {Trends in immunology},
  year    = {2016},
  doi     = {10.1016/j.it.2016.08.001},
  pmid    = {27616557},
  url     = {https://doi.org/10.1016/j.it.2016.08.001}
}

@article{cosenza2002-12408230,
  author  = {Cosenza, M. A. and Zhao, M. L. and Si, Q. and Lee, S. C.},
  title   = {{Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2002},
  doi     = {10.1111/j.1750-3639.2002.tb00461.x},
  pmid    = {12408230},
  url     = {https://doi.org/10.1111/j.1750-3639.2002.tb00461.x}
}

@article{mrak2001-11754999,
  author  = {Mrak, R. E. and Griffinbc, W. S.},
  title   = {{The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2001},
  doi     = {10.1016/s0197-4580(01)00293-7},
  pmid    = {11754999},
  url     = {https://doi.org/10.1016/s0197-4580(01)00293-7}
}

@article{matos2008-18790019,
  author  = {Matos, M. and Augusto, E. and Oliveira, C. R. and Agostinho, P.},
  title   = {{Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades}},
  journal = {Neuroscience},
  year    = {2008},
  doi     = {10.1016/j.neuroscience.2008.08.022},
  pmid    = {18790019},
  url     = {https://doi.org/10.1016/j.neuroscience.2008.08.022}
}

@article{glushakova2014-24564198,
  author  = {Glushakova, O. Y. and Johnson, D. and Hayes, R. L.},
  title   = {{Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage}},
  journal = {Journal of neurotrauma},
  year    = {2014},
  doi     = {10.1089/neu.2013.3080},
  pmid    = {24564198},
  url     = {https://doi.org/10.1089/neu.2013.3080}
}

@article{ladak2019-31301445,
  author  = {Ladak, A. A. and Enam, S. A. and Ibrahim, M. T.},
  title   = {{A Review of the Molecular Mechanisms of Traumatic Brain Injury}},
  journal = {World neurosurgery},
  year    = {2019},
  doi     = {10.1016/j.wneu.2019.07.039},
  pmid    = {31301445},
  url     = {https://doi.org/10.1016/j.wneu.2019.07.039}
}

@article{cooperknock2012-22890216,
  author  = {Cooper-Knock, J. and Kirby, J. and Ferraiuolo, L. and Heath, P. R. and Rattray, M. and Shaw, P. J.},
  title   = {{Gene expression profiling in human neurodegenerative disease}},
  journal = {Nature reviews. Neurology},
  year    = {2012},
  doi     = {10.1038/nrneurol.2012.156},
  pmid    = {22890216},
  url     = {https://doi.org/10.1038/nrneurol.2012.156}
}

@article{conant1999-10482270,
  author  = {Conant, K. and McArthur, J. C. and Griffin, D. E. and Sjulson, L. and Wahl, L. M. and Irani, D. N.},
  title   = {{Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia}},
  journal = {Annals of neurology},
  year    = {1999},
  doi     = {10.1002/1531-8249(199909)46:3<391::aid-ana15>3.0.co;2-0},
  pmid    = {10482270},
  url     = {https://doi.org/10.1002/1531-8249(199909)46:3<391::aid-ana15>3.0.co;2-0}
}

@article{yang2018-30099679,
  author  = {Yang, J. T. and Wang, Z. J. and Cai, H. Y. and Yuan, L. and Hu, M. M. and Wu, M. N. and Qi, J. S.},
  title   = {{Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer's Disease}},
  journal = {Neuroscience bulletin},
  year    = {2018},
  doi     = {10.1007/s12264-018-0268-9},
  pmid    = {30099679},
  url     = {https://doi.org/10.1007/s12264-018-0268-9}
}

@article{herholz2007-18445746,
  author  = {Herholz, K. and Carter, S. F. and Jones, M.},
  title   = {{Positron emission tomography imaging in dementia}},
  journal = {The British journal of radiology},
  year    = {2007},
  doi     = {10.1259/bjr/97295129},
  pmid    = {18445746},
  url     = {https://doi.org/10.1259/bjr/97295129}
}

@article{lunamedina2005-15817469,
  author  = {Luna-Medina, R. and Cortes-Canteli, M. and Alonso, M. and Santos, A. and Martínez, A. and Perez-Castillo, A.},
  title   = {{Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m414390200},
  pmid    = {15817469},
  url     = {https://doi.org/10.1074/jbc.m414390200}
}

@article{mayer2025-40254131,
  author  = {Mayer, Meredith G. and Fischer, Tracy},
  title   = {{Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in Coronavirus Disease 2019 and Alzheimer Disease}},
  journal = {American Journal Of Pathology},
  year    = {2025},
  doi     = {10.1016/j.ajpath.2025.03.011},
  pmid    = {40254131},
  url     = {https://doi.org/10.1016/j.ajpath.2025.03.011}
}

@article{katsoulaki2025-40573227,
  author  = {Katsoulaki, Eleftheria-Emmanouela and Dimopoulos, Dimitrios and Hadjipavlou‐Litina, Dimitra},
  title   = {{Multitarget Compounds Designed for Alzheimer, Parkinson, and Huntington Neurodegeneration Diseases}},
  journal = {Pharmaceuticals},
  year    = {2025},
  doi     = {10.3390/ph18060831},
  pmid    = {40573227},
  url     = {https://doi.org/10.3390/ph18060831}
}

@article{yang2025-40045356,
  author  = {Yang, Qu and Chen, Qi and Zhang, Kai-Bing and Liu, Yu and Zheng, Jia-Cheng and Hu, Dong-Xia and Luo, Jun},
  title   = {{Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-01950-z},
  pmid    = {40045356},
  url     = {https://doi.org/10.1186/s40478-025-01950-z}
}

@article{tsai2026-41516384,
  author  = {Tsai, Hui‐Yun and Qiu, Jing Yi and Liao, Han-Wei and Chang, Chi‐I and Chen, Yu-Hsiang and Ho, Chi‐Tang and Chen, Yu-Kuo and others},
  title   = {{Propyl Gallate Attenuates Methylglyoxal-Induced Alzheimer-like Cognitive Deficits and Neuroinflammation in Mice}},
  journal = {International Journal of Molecular Sciences},
  year    = {2026},
  doi     = {10.3390/ijms27010511},
  pmid    = {41516384},
  url     = {https://doi.org/10.3390/ijms27010511}
}

@article{ylmaz2025-40699631,
  author  = {Yılmaz, Habibe and Bayraktutan, Ulvi},
  title   = {{Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction}},
  journal = {Current Issues in Molecular Biology},
  year    = {2025},
  doi     = {10.3390/cimb47040232},
  pmid    = {40699631},
  url     = {https://doi.org/10.3390/cimb47040232}
}

@article{rui2025-39853966,
  author  = {Rui, Tongyu and Huang, He‐Zhou and Zheng, Kai and Fan, Hong‐Wei and Zhang, Juan and Guo, Ziyuan and Man, Heng‐Ye and Brazhe, Nadezda A. and others},
  title   = {{Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced Neurodegeneration}},
  journal = {Advanced Science},
  year    = {2025},
  doi     = {10.1002/advs.202410799},
  pmid    = {39853966},
  url     = {https://doi.org/10.1002/advs.202410799}
}

@article{choi2025-40592207,
  author  = {Choi, Jae-Won and Im, Joo Young and Balakrishnan, Rengasamy},
  title   = {{Paeoniflorin exercise-mimetic potential regulates the Nrf2/HO-1/BDNF/CREB and APP/BACE-1/NF-κB/MAPK signaling pathways to reduce cognitive impairments and neuroinflammation in amnesic mouse model}},
  journal = {Biomedicine \& Pharmacotherapy},
  year    = {2025},
  doi     = {10.1016/j.biopha.2025.118299},
  pmid    = {40592207},
  url     = {https://doi.org/10.1016/j.biopha.2025.118299}
}

@article{karkkainen2025-40471493,
  author  = {Kärkkäinen, Virve and Saari, Toni Tapani and Rusanen, Minna and Uusitalo, Hannu M. T. and Leinonen, Ville and Thiede, Bernd and Kaarniranta, Kai and Koivisto, Anne Maria and others},
  title   = {{Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease}},
  journal = {Journal of Molecular Neuroscience},
  year    = {2025},
  doi     = {10.1007/s12031-025-02368-x},
  pmid    = {40471493},
  url     = {https://doi.org/10.1007/s12031-025-02368-x}
}

@article{fine2025-39872995,
  author  = {Fine, Jared M. and Kosyakovsky, Jacob and Bowe, Tate T. and Faltesek, Katherine A. and STROEBEL, BENJAMIN M. and Abrahante, Juan E. and Kelly, Michael Robert and Thompson, Elizabeth A. and others},
  title   = {{Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease}},
  journal = {Frontiers in Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2024.1528374},
  pmid    = {39872995},
  url     = {https://doi.org/10.3389/fnins.2024.1528374}
}

@article{prinse2025-40754329,
  author  = {Prinse, F. A. M. and van der Weerd, L. and van Swieten, J. C. and Ronen, I. and Seelaar, H. and Hirschler, L. and Najac, C. and Dopper, E. G. P.},
  title   = {{Investigating the role of neuroinflammation and brain clearance in frontotemporal lobar degeneration using 7T MRI and fluid biomarkers: protocol for a cross-sectional study in a tertiary care setting}},
  journal = {BMJ open},
  year    = {2025},
  doi     = {10.1136/bmjopen-2025-102668},
  pmid    = {40754329},
  url     = {https://doi.org/10.1136/bmjopen-2025-102668}
}

@article{fischersmith2001-11704885,
  author  = {Fischer-Smith, T. and Croul, S. and Sverstiuk, A. E. and Capini, C. and L'Heureux, D. and Régulier, E. G. and Richardson, M. W. and Amini, S. and others},
  title   = {{CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection}},
  journal = {Journal of neurovirology},
  year    = {2001},
  doi     = {10.1080/135502801753248114},
  pmid    = {11704885},
  url     = {https://doi.org/10.1080/135502801753248114}
}

@article{dickson1988-2456021,
  author  = {Dickson, D. W. and Farlo, J. and Davies, P. and Crystal, H. and Fuld, P. and Yen, S. H.},
  title   = {{Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques}},
  journal = {The American journal of pathology},
  year    = {1988},
  pmid    = {2456021}
}

@article{davis1994-8193937,
  author  = {Davis, E. J. and Foster, T. D. and Thomas, W. E.},
  title   = {{Cellular forms and functions of brain microglia}},
  journal = {Brain research bulletin},
  year    = {1994},
  doi     = {10.1016/0361-9230(94)90189-9},
  pmid    = {8193937},
  url     = {https://doi.org/10.1016/0361-9230(94)90189-9}
}

@article{benveniste1990-2121800,
  author  = {Benveniste, E. N. and Sparacio, S. M. and Norris, J. G. and Grenett, H. E. and Fuller, G. M.},
  title   = {{Induction and regulation of interleukin-6 gene expression in rat astrocytes}},
  journal = {Journal of neuroimmunology},
  year    = {1990},
  doi     = {10.1016/0165-5728(90)90104-u},
  pmid    = {2121800},
  url     = {https://doi.org/10.1016/0165-5728(90)90104-u}
}

@article{mizuno2004-14975696,
  author  = {Mizuno, T. and Kurotani, T. and Komatsu, Y. and Kawanokuchi, J. and Kato, H. and Mitsuma, N. and Suzumura, A.},
  title   = {{Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia}},
  journal = {Neuropharmacology},
  year    = {2004},
  doi     = {10.1016/j.neuropharm.2003.09.009},
  pmid    = {14975696},
  url     = {https://doi.org/10.1016/j.neuropharm.2003.09.009}
}

@article{cunningham2015-25802557,
  author  = {Cunningham, C. and Hennessy, E.},
  title   = {{Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research}},
  journal = {Alzheimer's research \& therapy},
  year    = {2015},
  doi     = {10.1186/s13195-015-0117-2},
  pmid    = {25802557},
  url     = {https://doi.org/10.1186/s13195-015-0117-2}
}

@article{yadav2009-19768553,
  author  = {Yadav, A. and Collman, R. G.},
  title   = {{CNS inflammation and macrophage/microglial biology associated with HIV-1 infection}},
  journal = {Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology},
  year    = {2009},
  doi     = {10.1007/s11481-009-9174-2},
  pmid    = {19768553},
  url     = {https://doi.org/10.1007/s11481-009-9174-2}
}

@article{banisadr2002-12431218,
  author  = {Banisadr, G. and Fontanges, P. and Haour, F. and Kitabgi, P. and Rostène, W. and Mélik Parsadaniantz, S.},
  title   = {{Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons}},
  journal = {The European journal of neuroscience},
  year    = {2002},
  doi     = {10.1046/j.1460-9568.2002.02237.x},
  pmid    = {12431218},
  url     = {https://doi.org/10.1046/j.1460-9568.2002.02237.x}
}

@article{garden2002-12379911,
  author  = {Garden, G. A.},
  title   = {{Microglia in human immunodeficiency virus-associated neurodegeneration}},
  journal = {Glia},
  year    = {2002},
  doi     = {10.1002/glia.10155},
  pmid    = {12379911},
  url     = {https://doi.org/10.1002/glia.10155}
}

@article{jellinger2000-10809400,
  author  = {Jellinger, K. A.},
  title   = {{Cell death mechanisms in Parkinson's disease}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2000},
  doi     = {10.1007/s007020050001},
  pmid    = {10809400},
  url     = {https://doi.org/10.1007/s007020050001}
}

@article{yoon2025-40277896,
  author  = {Yoon, Chi‐Su},
  title   = {{Natural Products in the Treatment of Neuroinflammation at Microglia: Recent Trend and Features}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14080571},
  pmid    = {40277896},
  url     = {https://doi.org/10.3390/cells14080571}
}

@article{sturno2025-40089786,
  author  = {Sturno, Annalise M. and Hassell, James E. and Lanaspa, Miguel Angel and Bruce, Kimberley D.},
  title   = {{Do microglia metabolize fructose in Alzheimer’s disease?}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03401-x},
  pmid    = {40089786},
  url     = {https://doi.org/10.1186/s12974-025-03401-x}
}

@article{zhai2025-40151913,
  author  = {Zhai, Yanyu and Lu, Kaili and Yuan, Yuan and Zhang, Ziyao and Xue, Lixia and Zhao, Fei and Xu, Xiaofeng and Wang, Hongmei},
  title   = {{Semaglutide improves cognitive function and neuroinflammation in APP/PS1 transgenic mice by activating AMPK and inhibiting TLR4/NF-κB pathway}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251329439},
  pmid    = {40151913},
  url     = {https://doi.org/10.1177/13872877251329439}
}

@article{ferrarisouza2025-41449556,
  author  = {Ferrari‐Souza, João Pedro and Povala, Guilherme and Rahmouni, Nesrine and Bellaver, Bruna and Ferreira, Pâmela C.L. and Leffa, Douglas Teixeira and Lussier, Firoza Zubeida and Aguzzoli, Cristiano Schaffer and others},
  title   = {{Microglia as a key player in Aβ‐related astrocyte reactivity}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_102677},
  pmid    = {41449556},
  url     = {https://doi.org/10.1002/alz70856_102677}
}

@article{zhang2025-39923958,
  author  = {Zhang, Han and Bi, F.H. Tra and Zhao, Peng and Cui, Herong and Tao, Xiaojun and Zhang, Jianghua and Li, Chang and Cao, Yang and others},
  title   = {{Longan Aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia}},
  journal = {Journal of Ethnopharmacology},
  year    = {2025},
  doi     = {10.1016/j.jep.2025.119464},
  pmid    = {39923958},
  url     = {https://doi.org/10.1016/j.jep.2025.119464}
}

@article{alami2025-40111935,
  author  = {Alami, Mehdi and Zerif, Echarki and Khalil, Abdelouahed and Hajji, Nabil and Ramassamy, Charles and Lacombe, Guy and Laurent, Benoît and Cohen, Alan A. and others},
  title   = {{Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ 1–42 -induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251329474},
  pmid    = {40111935},
  url     = {https://doi.org/10.1177/13872877251329474}
}

@article{dematteis2025-40615914,
  author  = {Dematteis, Giulia and Gong, Chunmei and Malecka, Justyna and Tonelli, Elisa and Genazzani, Armando A. and Tapella, Laura and Eleuteri, Anna Maria and Lim, Dmitry and others},
  title   = {{Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01793-9},
  pmid    = {40615914},
  url     = {https://doi.org/10.1186/s13195-025-01793-9}
}

@article{porchietto2025-41009578,
  author  = {Porchietto, Elisa and Morello, Giulia and Cicilese, Giulia and Rainero, Innocenzo and Rubino, Elisa and Tamagno, Elena and Boschi, Silvia and Guglielmotto, Michela},
  title   = {{UCH-L1 in Alzheimer’s Disease: A Crucial Player in Dementia-Associated Mechanisms}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26189012},
  pmid    = {41009578},
  url     = {https://doi.org/10.3390/ijms26189012}
}

@article{akif2025-40462117,
  author  = {Akif, Adnan and Nguyen, T.T. and Liu, Langni and Xu, Xiaotian and Kulkarni, Amol A. and Jiang, Jianxiong and Zhang, Yang and Hao, Jiukuan},
  title   = {{Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia}},
  journal = {Fluids and Barriers of the CNS},
  year    = {2025},
  doi     = {10.1186/s12987-025-00665-6},
  pmid    = {40462117},
  url     = {https://doi.org/10.1186/s12987-025-00665-6}
}

@article{mizutani2026-41964274,
  author  = {Mizutani, Akane and Parra-Pérez, Carlos and Shindo, Akihiro and Lizasoaín, Ignacio and Moro, María Ángeles and Arai, Ken},
  title   = {{Neuroinflammation in vascular cognitive impairment and dementia: Insights from clinical biomarkers and experimental models}},
  journal = {Journal of Cerebral Blood Flow \& Metabolism},
  year    = {2026},
  doi     = {10.1177/0271678x261437523},
  pmid    = {41964274},
  url     = {https://doi.org/10.1177/0271678x261437523}
}

@article{lephart2026-41683663,
  author  = {Lephart, Edwin D. and Weber, K. Scott and Hedges, Dawson W.},
  title   = {{Assessing the Roles of Aging, Estrogen, Nutrition, and Neuroinflammation in Women and Their Involvement in Alzheimer’s Disease—A Narrative Overview}},
  journal = {International Journal of Molecular Sciences},
  year    = {2026},
  doi     = {10.3390/ijms27031239},
  pmid    = {41683663},
  url     = {https://doi.org/10.3390/ijms27031239}
}

@article{weng2026-41676156,
  author  = {Weng, Ying and He, Ting and Li, Mengzhu and Zhou, Qiuzhi and Xie, Jiazhao and Wei, Linyu and Wang, Xin and Wang, Jian-Zhi and others},
  title   = {{Microglial histone H3K18 crotonylation promotes STAT1 expression and induces cognitive deficit in Alzheimer disease}},
  journal = {Frontiers in Immunology},
  year    = {2026},
  doi     = {10.3389/fimmu.2026.1744375},
  pmid    = {41676156},
  url     = {https://doi.org/10.3389/fimmu.2026.1744375}
}

@article{capucho2026-41692039,
  author  = {Capucho, Adriana M. and de Leão, José Ponce and Flôr, Karine Corrêa and Melo, Gonçalo M. and Fernandes, M. and Sacramento, Joana F. and Conde, Sílvia V.},
  title   = {{Chronic caffeine consumption prevents obesity-induced cognitive and memory impairments by reducing neuroinflammation and enhancing neuronal activity in the hippocampus}},
  journal = {Pharmacological Research},
  year    = {2026},
  doi     = {10.1016/j.phrs.2026.108140},
  pmid    = {41692039},
  url     = {https://doi.org/10.1016/j.phrs.2026.108140}
}

@article{neupane2025-41465242,
  author  = {Neupane, Sandesh and Hortobágyi, Tibor},
  title   = {{Molecular Crossroads: Shared and Divergent Molecular Signatures in Alzheimer’s Disease and Dementia with Lewy Bodies}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms262411811},
  pmid    = {41465242},
  url     = {https://doi.org/10.3390/ijms262411811}
}

@article{zhao2025-39749650,
  author  = {Zhao, B. and Zang, P. and Quan, M. and Wang, Q. and Guo, D. and Jia, J. and Wang, W.},
  title   = {{The Effect of APOE ε4 on Alzheimer's Disease Fluid Biomarkers: A Cross-Sectional Study Based on the COAST}},
  journal = {CNS neuroscience \& therapeutics},
  year    = {2025},
  doi     = {10.1111/cns.70202},
  pmid    = {39749650},
  url     = {https://doi.org/10.1111/cns.70202}
}

@article{hazen2020-31414991,
  author  = {Hazen, J. and Vistnes, M. and Barca, M. L. and Eldholm, R. S. and Persson, K. and Brækhus, A. and Saltvedt, I. and Selbæk, G. and others},
  title   = {{The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2020},
  doi     = {10.1097/wad.0000000000000342},
  pmid    = {31414991},
  url     = {https://doi.org/10.1097/wad.0000000000000342}
}

@article{chun2022-35184428,
  author  = {Chun, M. Y. and Lee, J. and Jeong, J. H. and Roh, J. H. and Oh, S. J. and Oh, M. and Oh, J. S. and others},
  title   = {{18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment}},
  journal = {Yonsei medical journal},
  year    = {2022},
  doi     = {10.3349/ymj.2022.63.3.259},
  pmid    = {35184428},
  url     = {https://doi.org/10.3349/ymj.2022.63.3.259}
}

@article{avison2004-15579291,
  author  = {Avison, M. J. and Nath, A. and Greene-Avison, R. and Schmitt, F. A. and Greenberg, R. N. and Berger, JR.},
  title   = {{Neuroimaging correlates of HIV-associated BBB compromise}},
  journal = {Journal of neuroimmunology},
  year    = {2004},
  doi     = {10.1016/j.jneuroim.2004.08.025},
  pmid    = {15579291},
  url     = {https://doi.org/10.1016/j.jneuroim.2004.08.025}
}

@article{grimaldi2018-29880901,
  author  = {Grimaldi, A. and Brighi, C. and Peruzzi, G. and Ragozzino, D. and Bonanni, V. and Limatola, C. and Ruocco, G. and Di Angelantonio, S.},
  title   = {{Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model}},
  journal = {Cell death \& disease},
  year    = {2018},
  doi     = {10.1038/s41419-018-0740-5},
  pmid    = {29880901},
  url     = {https://doi.org/10.1038/s41419-018-0740-5}
}

@article{nilson2017-27716675,
  author  = {Nilson, A. N. and English, K. C. and Gerson, J. E. and Barton Whittle, T. and Nicolas Crain, C. and Xue, J. and Sengupta, U. and Castillo-Carranza, D. L. and others},
  title   = {{Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160912},
  pmid    = {27716675},
  url     = {https://doi.org/10.3233/jad-160912}
}

@article{yang2020-32963694,
  author  = {Yang, W. and Liu, Y. and Xu, Q. Q. and Xian, Y. F. and Lin, Z. X.},
  title   = {{Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2020},
  doi     = {10.1155/2020/4754195},
  pmid    = {32963694},
  url     = {https://doi.org/10.1155/2020/4754195}
}

@article{kim2018-30092810,
  author  = {Kim, C. and Spencer, B. and Rockenstein, E. and Yamakado, H. and Mante, M. and Adame, A. and Fields, J. A. and Masliah, D. and others},
  title   = {{Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0276-2},
  pmid    = {30092810},
  url     = {https://doi.org/10.1186/s13024-018-0276-2}
}

@article{michalicova2020-33100967,
  author  = {Michalicova, A. and Majerova, P. and Kovac, A.},
  title   = {{Tau Protein and Its Role in Blood-Brain Barrier Dysfunction}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2020},
  doi     = {10.3389/fnmol.2020.570045},
  pmid    = {33100967},
  url     = {https://doi.org/10.3389/fnmol.2020.570045}
}

@article{martin2017-27723233,
  author  = {Martin, E. and Boucher, C. and Fontaine, B. and Delarasse, C.},
  title   = {{Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology}},
  journal = {Aging cell},
  year    = {2017},
  doi     = {10.1111/acel.12522},
  pmid    = {27723233},
  url     = {https://doi.org/10.1111/acel.12522}
}

@article{ashok2020-33023198,
  author  = {Ashok, A. and Singh, N. and Chaudhary, S. and Bellamkonda, V. and Kritikos, A. E. and Wise, A. S. and Rana, N. and McDonald, D. and others},
  title   = {{Retinal Degeneration and Alzheimer's Disease: An Evolving Link}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21197290},
  pmid    = {33023198},
  url     = {https://doi.org/10.3390/ijms21197290}
}

@article{dupont2017-28387722,
  author  = {Dupont, A. C. and Largeau, B. and Santiago Ribeiro, M. J. and Guilloteau, D. and Tronel, C. and Arlicot, N.},
  title   = {{Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2017},
  doi     = {10.3390/ijms18040785},
  pmid    = {28387722},
  url     = {https://doi.org/10.3390/ijms18040785}
}

@article{kwon2020-33239064,
  author  = {Kwon, H. S. and Koh, S. H.},
  title   = {{Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes}},
  journal = {Translational neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s40035-020-00221-2},
  pmid    = {33239064},
  url     = {https://doi.org/10.1186/s40035-020-00221-2}
}

@article{fang2019-30742114,
  author  = {Fang, E. F. and Hou, Y. and Palikaras, K. and Adriaanse, B. A. and Kerr, J. S. and Yang, B. and Lautrup, S. and Hasan-Olive, M. M. and others},
  title   = {{Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-018-0332-9},
  pmid    = {30742114},
  url     = {https://doi.org/10.1038/s41593-018-0332-9}
}

@article{dominy2019-30746447,
  author  = {Dominy, S. S. and Lynch, C. and Ermini, F. and Benedyk, M. and Marczyk, A. and Konradi, A. and Nguyen, M. and Haditsch, U. and others},
  title   = {{Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors}},
  journal = {Science advances},
  year    = {2019},
  doi     = {10.1126/sciadv.aau3333},
  pmid    = {30746447},
  url     = {https://doi.org/10.1126/sciadv.aau3333}
}

@article{iaccarino2016-27929004,
  author  = {Iaccarino, H. F. and Singer, A. C. and Martorell, A. J. and Rudenko, A. and Gao, F. and Gillingham, T. Z. and Mathys, H. and Seo, J. and others},
  title   = {{Gamma frequency entrainment attenuates amyloid load and modifies microglia}},
  journal = {Nature},
  year    = {2016},
  doi     = {10.1038/nature20587},
  pmid    = {27929004},
  url     = {https://doi.org/10.1038/nature20587}
}

@article{meda1995-7715705,
  author  = {Meda, L. and Cassatella, M. A. and Szendrei, G. I. and Otvos, L. and Baron, P. and Villalba, M. and Ferrari, D. and Rossi, F.},
  title   = {{Activation of microglial cells by beta-amyloid protein and interferon-gamma}},
  journal = {Nature},
  year    = {1995},
  doi     = {10.1038/374647a0},
  pmid    = {7715705},
  url     = {https://doi.org/10.1038/374647a0}
}

@article{zhang2019-30936558,
  author  = {Zhang, P. and Kishimoto, Y. and Grammatikakis, I. and Gottimukkala, K. and Cutler, R. G. and Zhang, S. and Abdelmohsen, K. and Bohr, V. A. and others},
  title   = {{Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0372-9},
  pmid    = {30936558},
  url     = {https://doi.org/10.1038/s41593-019-0372-9}
}

@article{simpson2020-32823544,
  author  = {Simpson, D. S. A. and Oliver, P. L.},
  title   = {{ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2020},
  doi     = {10.3390/antiox9080743},
  pmid    = {32823544},
  url     = {https://doi.org/10.3390/antiox9080743}
}

@article{hambright2017-28212525,
  author  = {Hambright, W. S. and Fonseca, R. S. and Chen, L. and Na, R. and Ran, Q.},
  title   = {{Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration}},
  journal = {Redox biology},
  year    = {2017},
  doi     = {10.1016/j.redox.2017.01.021},
  pmid    = {28212525},
  url     = {https://doi.org/10.1016/j.redox.2017.01.021}
}

@article{jo2014-24973918,
  author  = {Jo, S. and Yarishkin, O. and Hwang, Y. J. and Chun, Y. E. and Park, M. and Woo, D. H. and Bae, J. Y. and Kim, T. and others},
  title   = {{GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2014},
  doi     = {10.1038/nm.3639},
  pmid    = {24973918},
  url     = {https://doi.org/10.1038/nm.3639}
}

@article{rutsch2020-33362788,
  author  = {Rutsch, A. and Kantsjö, J. B. and Ronchi, F.},
  title   = {{The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.604179},
  pmid    = {33362788},
  url     = {https://doi.org/10.3389/fimmu.2020.604179}
}

@article{merighi2022-36361780,
  author  = {Merighi, Stefania and Nigro, Manuela and Travagli, Alessia and Gessi, Stefania},
  title   = {{Microglia and Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms232112990},
  pmid    = {36361780},
  url     = {https://doi.org/10.3390/ijms232112990}
}

@article{hou2021-34497121,
  author  = {Hou, Yujun and Wei, Yong and Lautrup, Sofie and Yang, Beimeng and Wang, Yue and Cordonnier, Stephanie and Mattson, Mark P and Croteau, Deborah L and others},
  title   = {{NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2011226118},
  pmid    = {34497121},
  url     = {https://doi.org/10.1073/pnas.2011226118}
}

@article{kim2021-34638977,
  author  = {Kim, Jieun and Lee, Hyun-Ju and Park, Seon Kyeong and Park, Jin-Hee and Jeong, Ha-Ram and Lee, Soojung and Lee, Heeyong and Seol, Eunyoung and others},
  title   = {{Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms221910637},
  pmid    = {34638977},
  url     = {https://doi.org/10.3390/ijms221910637}
}

@article{freitag2022-35780157,
  author  = {Freitag, Kiara and Sterczyk, Nele and Wendlinger, Sarah and Obermayer, Benedikt and Schulz, Julia and Farztdinov, Vadim and Mülleder, Michael and Ralser, Markus and others},
  title   = {{Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02534-7},
  pmid    = {35780157},
  url     = {https://doi.org/10.1186/s12974-022-02534-7}
}

@article{dedios2023-36895045,
  author  = {de Dios, Cristina and Abadin, Xenia and Roca-Agujetas, Vicente and Jimenez-Martinez, Marina and Morales, Albert and Trullas, Ramon and Mari, Montserrat and Colell, Anna},
  title   = {{Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis}},
  journal = {Translational neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s40035-023-00343-3},
  pmid    = {36895045},
  url     = {https://doi.org/10.1186/s40035-023-00343-3}
}

@article{gong2022-36017373,
  author  = {Gong, Ting and Chen, Qi and Mao, Hongchen and Zhang, Yao and Ren, Huan and Xu, Mengmeng and Chen, Hong and Yang, Deqin},
  title   = {{Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice}},
  journal = {Frontiers in cellular and infection microbiology},
  year    = {2022},
  doi     = {10.3389/fcimb.2022.925435},
  pmid    = {36017373},
  url     = {https://doi.org/10.3389/fcimb.2022.925435}
}

@article{li2023-37165444,
  author  = {Li, Jia-Mei and Hu, Ting and Zhou, Xiao-Na and Zhang, Ting and Guo, Jia-Hui and Wang, Min-Yuan and Wu, Yi-Lin and Su, Wen-Jun and others},
  title   = {{The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02791-0},
  pmid    = {37165444},
  url     = {https://doi.org/10.1186/s12974-023-02791-0}
}

@article{shah2021-34948444,
  author  = {Shah, Akash and Kishore, Uday and Shastri, Abhishek},
  title   = {{Complement System in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222413647},
  pmid    = {34948444},
  url     = {https://doi.org/10.3390/ijms222413647}
}

@article{he2021-34229722,
  author  = {He, Xiao-Fei and Li, Li-Li and Xian, Wen-Biao and Li, Ming-Yue and Zhang, Li-Ying and Xu, Jing-Hui and Pei, Zhong and Zheng, Hai-Qing and others},
  title   = {{Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-021-02199-8},
  pmid    = {34229722},
  url     = {https://doi.org/10.1186/s12974-021-02199-8}
}

@article{shu2023-36800288,
  author  = {Shu, Xiaoqiu and Wei, Chen and Tu, Wen-Yo and Zhong, Keke and Qi, Shuyuan and Wang, Ailian and Bai, Lei and Zhang, Shan-Xin and others},
  title   = {{Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome}},
  journal = {Cell reports},
  year    = {2023},
  doi     = {10.1016/j.celrep.2023.112133},
  pmid    = {36800288},
  url     = {https://doi.org/10.1016/j.celrep.2023.112133}
}

@article{vanzeller2021-34366341,
  author  = {Van Zeller, Mariana and Dias, Diogo and Sebastião, Ana M and Valente, Cláudia A},
  title   = {{NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210268},
  pmid    = {34366341},
  url     = {https://doi.org/10.3233/jad-210268}
}

@article{ravichandran2021-34846519,
  author  = {Ravichandran, Kishore Aravind and Heneka, Michael T},
  title   = {{Inflammasome activation in neurodegenerative diseases}},
  journal = {Essays in biochemistry},
  year    = {2021},
  doi     = {10.1042/ebc20210021},
  pmid    = {34846519},
  url     = {https://doi.org/10.1042/ebc20210021}
}

@article{barczuk2022-36012243,
  author  = {Barczuk, Julia and Siwecka, Natalia and Lusa, Weronika and Rozpędek-Kamińska, Wioletta and Kucharska, Ewa and Majsterek, Ireneusz},
  title   = {{Targeting NLRP3-Mediated Neuroinflammation in Alzheimer's Disease Treatment}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23168979},
  pmid    = {36012243},
  url     = {https://doi.org/10.3390/ijms23168979}
}

@article{zhou2023-37268807,
  author  = {Zhou, Ran and Chen, Shih-Heng and Zhao, Zhan and Tu, Dezhen and Song, Sheng and Wang, Yubao and Wang, Qingshan and Feng, Jing and others},
  title   = {{Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-023-03393-w},
  pmid    = {37268807},
  url     = {https://doi.org/10.1007/s12035-023-03393-w}
}

@article{holbrook2021-33776778,
  author  = {Holbrook, Jonathan A and Jarosz-Griffiths, Heledd H and Caseley, Emily and Lara-Reyna, Samuel and Poulter, James A and Williams-Gray, Caroline H and Peckham, Daniel and McDermott, Michael F},
  title   = {{Neurodegenerative Disease and the NLRP3 Inflammasome}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.643254},
  pmid    = {33776778},
  url     = {https://doi.org/10.3389/fphar.2021.643254}
}

@article{rather2021-34381308,
  author  = {Rather, Mashoque Ahmad and Khan, Andleeb and Alshahrani, Saeed and Rashid, Hina and Qadri, Marwa and Rashid, Summya and Alsaffar, Rana M and Kamal, Mohammad Amjad and others},
  title   = {{Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products}},
  journal = {Mediators of inflammation},
  year    = {2021},
  doi     = {10.1155/2021/9982954},
  pmid    = {34381308},
  url     = {https://doi.org/10.1155/2021/9982954}
}

@article{zhang2021-34430820,
  author  = {Zhang, Liansheng and Qian, Yun and Li, Jie and Zhou, Xuan and Xu, He and Yan, Jie and Xiang, Jialing and Yuan, Xiang and others},
  title   = {{BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology}},
  journal = {iScience},
  year    = {2021},
  doi     = {10.1016/j.isci.2021.102942},
  pmid    = {34430820},
  url     = {https://doi.org/10.1016/j.isci.2021.102942}
}

@article{lee2021-34668411,
  author  = {Lee, SangJoon and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Innate Immunity and Cell Death in Alzheimer's Disease}},
  journal = {ASN neuro},
  year    = {2021},
  doi     = {10.1177/17590914211051908},
  pmid    = {34668411},
  url     = {https://doi.org/10.1177/17590914211051908}
}

@article{milner2021-33181351,
  author  = {Milner, Mark T and Maddugoda, Madhavi and Götz, Jürgen and Burgener, Sabrina S and Schroder, Kate},
  title   = {{The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease}},
  journal = {Current opinion in immunology},
  year    = {2021},
  doi     = {10.1016/j.coi.2020.10.011},
  pmid    = {33181351},
  url     = {https://doi.org/10.1016/j.coi.2020.10.011}
}

@article{toscano2021-34530705,
  author  = {Toscano, Eliana C de Brito and Rocha, Natalia P and Lopes, Beatriz N A and Suemoto, Claudia K and Teixeira, Antonio L},
  title   = {{Neuroinflammation in Alzheimer's Disease: Focus on NLRP1 and NLRP3 Inflammasomes}},
  journal = {Current protein \& peptide science},
  year    = {2021},
  doi     = {10.2174/1389203722666210916141436},
  pmid    = {34530705},
  url     = {https://doi.org/10.2174/1389203722666210916141436}
}

@article{ayyubova2023-36302379,
  author  = {Ayyubova, Gunel},
  title   = {{Dysfunctional microglia and tau pathology in Alzheimer's disease}},
  journal = {Reviews in the neurosciences},
  year    = {2023},
  doi     = {10.1515/revneuro-2022-0087},
  pmid    = {36302379},
  url     = {https://doi.org/10.1515/revneuro-2022-0087}
}

@article{poh2022-35000611,
  author  = {Poh, Luting and Sim, Wei Liang and Jo, Dong-Gyu and Dinh, Quynh Nhu and Drummond, Grant R and Sobey, Christopher G and Chen, Christopher Li-Hsian and Lai, Mitchell K P and others},
  title   = {{The role of inflammasomes in vascular cognitive impairment}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-021-00506-8},
  pmid    = {35000611},
  url     = {https://doi.org/10.1186/s13024-021-00506-8}
}

@article{gao2023-37328043,
  author  = {Gao, Dan and Hao, Jin-Ping and Li, Bo-Ya and Zheng, Ceng-Ceng and Miao, Bei-Bei and Zhang, Li and Li, Ya-Li and Li, Lin and others},
  title   = {{Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING}},
  journal = {European journal of pharmacology},
  year    = {2023},
  doi     = {10.1016/j.ejphar.2023.175809},
  pmid    = {37328043},
  url     = {https://doi.org/10.1016/j.ejphar.2023.175809}
}

@article{sandhu2021-33499208,
  author  = {Sandhu, Jagdeep K and Kulka, Marianna},
  title   = {{Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22031093},
  pmid    = {33499208},
  url     = {https://doi.org/10.3390/ijms22031093}
}

@article{mamsa2023-37652164,
  author  = {Mamsa, Rumaiza and Prabhavalkar, Kedar S and Bhatt, Lokesh Kumar},
  title   = {{Crosstalk between NLRP3 inflammasome and calpain in Alzheimer's disease}},
  journal = {The European journal of neuroscience},
  year    = {2023},
  doi     = {10.1111/ejn.16139},
  pmid    = {37652164},
  url     = {https://doi.org/10.1111/ejn.16139}
}

@article{trudler2021-33833060,
  author  = {Trudler, Dorit and Nazor, Kristopher L and Eisele, Yvonne S and Grabauskas, Titas and Dolatabadi, Nima and Parker, James and Sultan, Abdullah and Zhong, Zhenyu and others},
  title   = {{Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2025847118},
  pmid    = {33833060},
  url     = {https://doi.org/10.1073/pnas.2025847118}
}

@article{abdallah2022-35263086,
  author  = {Abdallah, Ihab M and Al-Shami, Kamal M and Yang, Euitaek and Wang, Junwei and Guillaume, Claudia and Kaddoumi, Amal},
  title   = {{Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer's Disease Mouse Model}},
  journal = {ACS chemical neuroscience},
  year    = {2022},
  doi     = {10.1021/acschemneuro.2c00005},
  pmid    = {35263086},
  url     = {https://doi.org/10.1021/acschemneuro.2c00005}
}

@article{lei2021-33641782,
  author  = {Lei, Li-Yan and Wang, Rui-Cheng and Pan, Ya-Lei and Yue, Zheng-Gang and Zhou, Rui and Xie, Pei and Tang, Zhi-Shu},
  title   = {{Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway}},
  journal = {Chinese journal of natural medicines},
  year    = {2021},
  doi     = {10.1016/s1875-5364(21)60012-2},
  pmid    = {33641782},
  url     = {https://doi.org/10.1016/s1875-5364(21)60012-2}
}

@article{chen2022-36353622,
  author  = {Chen, Yu and Peng, Fu and Xing, Ziwei and Chen, Junren and Peng, Cheng and Li, Dan},
  title   = {{Beneficial effects of natural flavonoids on neuroinflammation}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.1006434},
  pmid    = {36353622},
  url     = {https://doi.org/10.3389/fimmu.2022.1006434}
}

@article{shukla2021-33916001,
  author  = {Shukla, Pradeep K and Delotterie, David F and Xiao, Jianfeng and Pierre, Joseph F and Rao, RadhaKrishna and McDonald, Michael P and Khan, Mohammad Moshahid},
  title   = {{Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer's Disease}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10040779},
  pmid    = {33916001},
  url     = {https://doi.org/10.3390/cells10040779}
}

@article{brahadeeswaran2022-35066762,
  author  = {Brahadeeswaran, Subhashini and Sivagurunathan, Narmadhaa and Calivarathan, Latchoumycandane},
  title   = {{Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases}},
  journal = {Molecular neurobiology},
  year    = {2022},
  doi     = {10.1007/s12035-021-02683-5},
  pmid    = {35066762},
  url     = {https://doi.org/10.1007/s12035-021-02683-5}
}

@article{jia2023-37721665,
  author  = {Jia, Yue-Ran and Guo, Zi-Qing and Guo, Qian and Wang, Xiao-Chuan},
  title   = {{Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer's Disease}},
  journal = {Current medical science},
  year    = {2023},
  doi     = {10.1007/s11596-023-2788-4},
  pmid    = {37721665},
  url     = {https://doi.org/10.1007/s11596-023-2788-4}
}

@article{han2023-37725102,
  author  = {Han, Ying-Hao and Liu, Xiao-Dong and Jin, Mei-Hua and Sun, Hu-Nan and Kwon, Taeho},
  title   = {{Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases}},
  journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]},
  year    = {2023},
  doi     = {10.1007/s00011-023-01790-4},
  pmid    = {37725102},
  url     = {https://doi.org/10.1007/s00011-023-01790-4}
}

@article{xu2021-34187889,
  author  = {Xu, Yin and Propson, Nicholas E and Du, Shuqi and Xiong, Wen and Zheng, Hui},
  title   = {{Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2023418118},
  pmid    = {34187889},
  url     = {https://doi.org/10.1073/pnas.2023418118}
}

@article{bohlson2023-36750318,
  author  = {Bohlson, Suzanne S and Tenner, Andrea J},
  title   = {{Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation}},
  journal = {Annual review of immunology},
  year    = {2023},
  doi     = {10.1146/annurev-immunol-101921-035639},
  pmid    = {36750318},
  url     = {https://doi.org/10.1146/annurev-immunol-101921-035639}
}

@article{susjanleite2022-35979366,
  author  = {Sušjan-Leite, Petra and Ramuta, Taja Železnik and Boršić, Elvira and Orehek, Sara and Hafner-Bratkovič, Iva},
  title   = {{Supramolecular organizing centers at the interface of inflammation and neurodegeneration}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.940969},
  pmid    = {35979366},
  url     = {https://doi.org/10.3389/fimmu.2022.940969}
}

@article{xin2022-35229660,
  author  = {Xin, Yue-Yang and Wang, Jin-Xu and Xu, Ai-Jun},
  title   = {{Electroacupuncture ameliorates neuroinflammation in animal models}},
  journal = {Acupuncture in medicine : journal of the British Medical Acupuncture Society},
  year    = {2022},
  doi     = {10.1177/09645284221076515},
  pmid    = {35229660},
  url     = {https://doi.org/10.1177/09645284221076515}
}

@article{chen2023-36018184,
  author  = {Chen, Feng and Liu, Jing and Li, Fa-Qiang and Wang, Shuai-Shuai and Zhang, Yan-Yan and Lu, Yun-Yun and Hu, Fang-Fang and Yao, Rui-Qin},
  title   = {{β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats}},
  journal = {Neural regeneration research},
  year    = {2023},
  doi     = {10.4103/1673-5374.350204},
  pmid    = {36018184},
  url     = {https://doi.org/10.4103/1673-5374.350204}
}

@article{golzarisorkheh2021-34569958,
  author  = {Golzari-Sorkheh, Mahdieh and Brown, Carla E and Weaver, Donald F and Reed, Mark A},
  title   = {{The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210660},
  pmid    = {34569958},
  url     = {https://doi.org/10.3233/jad-210660}
}

@article{lu2022-36262883,
  author  = {Lu, Ranran and Zhang, Lijie and Yang, Xinling},
  title   = {{Interaction between autophagy and the NLRP3 inflammasome in Alzheimer's and Parkinson's disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.1018848},
  pmid    = {36262883},
  url     = {https://doi.org/10.3389/fnagi.2022.1018848}
}

@article{jung2022-35474599,
  author  = {Jung, Eun Sun and Suh, Kyujin and Han, Jihui and Kim, Heyyoung and Kang, Hyung-Sik and Choi, Won-Seok and Mook-Jung, Inhee},
  title   = {{Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway}},
  journal = {Aging cell},
  year    = {2022},
  doi     = {10.1111/acel.13623},
  pmid    = {35474599},
  url     = {https://doi.org/10.1111/acel.13623}
}

@article{sita2021-34209586,
  author  = {Sita, Giulia and Graziosi, Agnese and Hrelia, Patrizia and Morroni, Fabiana},
  title   = {{NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22136984},
  pmid    = {34209586},
  url     = {https://doi.org/10.3390/ijms22136984}
}

@article{ghosh2021-34656693,
  author  = {Ghosh, Powsali and Singh, Ravi and Ganeshpurkar, Ankit and Pokle, Ankit Vyankatrao and Singh, Ravi Bhushan and Singh, Sushil Kumar and Kumar, Ashok},
  title   = {{Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts \& roles}},
  journal = {Neurochemistry international},
  year    = {2021},
  doi     = {10.1016/j.neuint.2021.105212},
  pmid    = {34656693},
  url     = {https://doi.org/10.1016/j.neuint.2021.105212}
}

@article{brabers2006-16796601,
  author  = {Brabers, N. A. and Nottet, H. S.},
  title   = {{Role of the pro-inflammatory cytokines TNF-alpha and IL-1beta in HIV-associated dementia}},
  journal = {European journal of clinical investigation},
  year    = {2006},
  doi     = {10.1111/j.1365-2362.2006.01657.x},
  pmid    = {16796601},
  url     = {https://doi.org/10.1111/j.1365-2362.2006.01657.x}
}

@article{li2011-21143158,
  author  = {Li, C. and Zhao, R. and Gao, K. and Wei, Z. and Yin, M. Y. and Lau, L. T. and Chui, D. and Yu, A. C.},
  title   = {{Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease}},
  journal = {Current Alzheimer research},
  year    = {2011},
  doi     = {10.2174/156720511794604543},
  pmid    = {21143158},
  url     = {https://doi.org/10.2174/156720511794604543}
}

@article{rosenkranz2007-17582512,
  author  = {Rosenkranz, D. and Weyer, S. and Tolosa, E. and Gaenslen, A. and Berg, D. and Leyhe, T. and Gasser, T. and Stoltze, L.},
  title   = {{Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration}},
  journal = {Journal of neuroimmunology},
  year    = {2007},
  doi     = {10.1016/j.jneuroim.2007.05.011},
  pmid    = {17582512},
  url     = {https://doi.org/10.1016/j.jneuroim.2007.05.011}
}

@article{hazell1999-10564534,
  author  = {Hazell, A. S. and Butterworth, R. F.},
  title   = {{Hepatic encephalopathy: An update of pathophysiologic mechanisms}},
  journal = {Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)},
  year    = {1999},
  doi     = {10.1046/j.1525-1373.1999.d01-120.x},
  pmid    = {10564534},
  url     = {https://doi.org/10.1046/j.1525-1373.1999.d01-120.x}
}

@article{kohler2016-27604604,
  author  = {Köhler, C. A. and Maes, M. and Slyepchenko, A. and Berk, M. and Solmi, M. and Lanctôt, K. L. and Carvalho, A. F.},
  title   = {{The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer's Disease}},
  journal = {Current pharmaceutical design},
  year    = {2016},
  doi     = {10.2174/1381612822666160907093807},
  pmid    = {27604604},
  url     = {https://doi.org/10.2174/1381612822666160907093807}
}

@article{dhandapani2002-12390866,
  author  = {Dhandapani, K. M. and Brann, D. W.},
  title   = {{Protective effects of estrogen and selective estrogen receptor modulators in the brain}},
  journal = {Biology of reproduction},
  year    = {2002},
  doi     = {10.1095/biolreprod.102.003848},
  pmid    = {12390866},
  url     = {https://doi.org/10.1095/biolreprod.102.003848}
}

@article{lavi1997-9327737,
  author  = {Lavi, E. and Strizki, J. M. and Ulrich, A. M. and Zhang, W. and Fu, L. and Wang, Q. and O'Connor, M. and Hoxie, J. A. and others},
  title   = {{CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons}},
  journal = {The American journal of pathology},
  year    = {1997},
  pmid    = {9327737}
}

@article{grammas2011-21676288,
  author  = {Grammas, P. and Martinez, J. and Miller, B.},
  title   = {{Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases}},
  journal = {Expert reviews in molecular medicine},
  year    = {2011},
  doi     = {10.1017/s1462399411001918},
  pmid    = {21676288},
  url     = {https://doi.org/10.1017/s1462399411001918}
}

@article{wu2004-15285800,
  author  = {Wu, S. Z. and Bodles, A. M. and Porter, M. M. and Griffin, W. S. and Basile, A. S. and Barger, S. W.},
  title   = {{Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide}},
  journal = {Journal of neuroinflammation},
  year    = {2004},
  doi     = {10.1186/1742-2094-1-2},
  pmid    = {15285800},
  url     = {https://doi.org/10.1186/1742-2094-1-2}
}

@article{angst2025-40395993,
  author  = {Angst, Gabrielle and Jia, Nuo and Esqueda, Luis Tron and Fan, Yanbo and Cai, Qian and Wang, Chenran},
  title   = {{Autophagy in alzheimer disease pathogenesis and its therapeutic values}},
  journal = {Autophagy Reports},
  year    = {2025},
  doi     = {10.1080/27694127.2025.2471677},
  pmid    = {40395993},
  url     = {https://doi.org/10.1080/27694127.2025.2471677}
}

@article{khan2025-40757092,
  author  = {Khan, Romeesa and Devlin, Patrick J. and Urayama, Akihiko and Ritzel, Rodney M.},
  title   = {{Models and mechanisms of post-stroke dementia and cognitive impairment}},
  journal = {Frontiers in Stroke},
  year    = {2025},
  doi     = {10.3389/fstro.2025.1563924},
  pmid    = {40757092},
  url     = {https://doi.org/10.3389/fstro.2025.1563924}
}

@article{chaigneau2025-40304030,
  author  = {Chaigneau, Thomas and Sha, Sha and Roux, Candice M. and Aïd, Saba and Faucher, Alice and Chantran, Yannick and Dorothée, Guillaume and Krantic, Slavica},
  title   = {{Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology}},
  journal = {Glia},
  year    = {2025},
  doi     = {10.1002/glia.70029},
  pmid    = {40304030},
  url     = {https://doi.org/10.1002/glia.70029}
}

@article{jaisaaad2025-41436365,
  author  = {Jaisa-aad, Methasit and Agüero, Cinthya and Rabaneda‐Lombarte, Neus and Bianco, Celia and Melloni, Alexandra N. and Hyman, Bradley T. and Gómez‐Isla, Teresa and Brugarolas, Pedro and others},
  title   = {{Monoamine Oxidase‐B (MAO‐B) Identifies Neurotoxic Reactive Astrocytes in Alzheimer's Disease and Related Dementias}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_102019},
  pmid    = {41436365},
  url     = {https://doi.org/10.1002/alz70855_102019}
}

@article{weiss2025-40816764,
  author  = {Weiss, Blaine E. and Gant, John C. and Lin, Ruei‐Lung and Gollihue, Jenna L. and Rogers, Colin B. and Kraner, Susan D. and Rucker, Edmund B. and Katsumata, Yuriko and others},
  title   = {{Disrupted Calcium Dynamics in Reactive Astrocytes Occur with End Feet–Arteriole Decoupling in an Amyloid Mouse Model of Alzheimer's Disease}},
  journal = {Journal of Neuroscience},
  year    = {2025},
  doi     = {10.1523/jneurosci.0349-25.2025},
  pmid    = {40816764},
  url     = {https://doi.org/10.1523/jneurosci.0349-25.2025}
}

@article{bowirrat2025-40943177,
  author  = {Bowirrat, Abdalla and Pinhasov, Albert and Bowirrat, Aia and Badgaiyan, Rajendra Dhar},
  title   = {{Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and Neuroinflammation}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26178253},
  pmid    = {40943177},
  url     = {https://doi.org/10.3390/ijms26178253}
}

@article{zheng2025-40919134,
  author  = {Zheng, Kai and Huang, He‐Zhou and Liu, Dan and Brazhe, Nadezda A. and Chen, Jiajie and Zhu, Ling‐Qiang},
  title   = {{Targeting the miR‐96‐5p/Cathepsin B Pathway to Alleviate Neuron‐Derived Neuroinflammation in Alzheimer's Disease}},
  journal = {MedComm},
  year    = {2025},
  doi     = {10.1002/mco2.70368},
  pmid    = {40919134},
  url     = {https://doi.org/10.1002/mco2.70368}
}

@article{song2026-41540503,
  author  = {Song, Chengcheng and Wu, Pau Yen and Huffman, William J. and David‐Bercholz, Jennifer and Bedolla, Alicia and Velagapudi, Ravikanth and Njoroge, Ann Wangechi and Rodriguiz, Ramona M. and others},
  title   = {{Electrical stimulation of the vagus nerve improves amyloid pathology in delirium superimposed on dementia}},
  journal = {Bioelectronic Medicine},
  year    = {2026},
  doi     = {10.1186/s42234-025-00194-5},
  pmid    = {41540503},
  url     = {https://doi.org/10.1186/s42234-025-00194-5}
}

@article{ghafouri2006-16712719,
  author  = {Ghafouri, M. and Amini, S. and Khalili, K. and Sawaya, B. E.},
  title   = {{HIV-1 associated dementia: symptoms and causes}},
  journal = {Retrovirology},
  year    = {2006},
  doi     = {10.1186/1742-4690-3-28},
  pmid    = {16712719},
  url     = {https://doi.org/10.1186/1742-4690-3-28}
}

@article{fellner2011-21562886,
  author  = {Fellner, L. and Jellinger, K. A. and Wenning, G. K. and Stefanova, N.},
  title   = {{Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts}},
  journal = {Acta neuropathologica},
  year    = {2011},
  doi     = {10.1007/s00401-011-0833-z},
  pmid    = {21562886},
  url     = {https://doi.org/10.1007/s00401-011-0833-z}
}

@article{rocha2015-26094487,
  author  = {Rocha, E. M. and Smith, G. A. and Park, E. and Cao, H. and Graham, A. R. and Brown, E. and McLean, JR. and Hayes, M. A. and others},
  title   = {{Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice}},
  journal = {Antioxidants \& redox signaling},
  year    = {2015},
  doi     = {10.1089/ars.2015.6307},
  pmid    = {26094487},
  url     = {https://doi.org/10.1089/ars.2015.6307}
}

@article{hu2015-25871773,
  author  = {Hu, J. and Liu, C. C. and Chen, X. F. and Zhang, Y. W. and Xu, H. and Bu, G.},
  title   = {{Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0001-3},
  pmid    = {25871773},
  url     = {https://doi.org/10.1186/s13024-015-0001-3}
}

@article{lee2010-20972375,
  author  = {Lee, H. J. and Kim, C. and Lee, S. J.},
  title   = {{Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2010},
  doi     = {10.4161/oxim.3.4.12809},
  pmid    = {20972375},
  url     = {https://doi.org/10.4161/oxim.3.4.12809}
}

@article{sweeney2016-27227366,
  author  = {Sweeney, M. D. and Ayyadurai, S. and Zlokovic, B. V.},
  title   = {{Pericytes of the neurovascular unit: key functions and signaling pathways}},
  journal = {Nature neuroscience},
  year    = {2016},
  doi     = {10.1038/nn.4288},
  pmid    = {27227366},
  url     = {https://doi.org/10.1038/nn.4288}
}

@article{hooper2008-18088381,
  author  = {Hooper, C. and Killick, R. and Lovestone, S.},
  title   = {{The GSK3 hypothesis of Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2007.05194.x},
  pmid    = {18088381},
  url     = {https://doi.org/10.1111/j.1471-4159.2007.05194.x}
}

@article{edwards2008-18762209,
  author  = {Edwards, D. R. and Handsley, M. M. and Pennington, C. J.},
  title   = {{The ADAM metalloproteinases}},
  journal = {Molecular aspects of medicine},
  year    = {2008},
  doi     = {10.1016/j.mam.2008.08.001},
  pmid    = {18762209},
  url     = {https://doi.org/10.1016/j.mam.2008.08.001}
}

@article{streit2004-15285801,
  author  = {Streit, W. J. and Mrak, R. E. and Griffin, W. S.},
  title   = {{Microglia and neuroinflammation: a pathological perspective}},
  journal = {Journal of neuroinflammation},
  year    = {2004},
  doi     = {10.1186/1742-2094-1-14},
  pmid    = {15285801},
  url     = {https://doi.org/10.1186/1742-2094-1-14}
}

@article{pan2022-35303422,
  author  = {Pan, R. Y. and He, L. and Zhang, J. and Liu, X. and Liao, Y. and Gao, J. and Yan, Y. and others},
  title   = {{Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease}},
  journal = {Cell metabolism},
  year    = {2022},
  doi     = {10.1016/j.cmet.2022.02.013},
  pmid    = {35303422},
  url     = {https://doi.org/10.1016/j.cmet.2022.02.013}
}

@article{mccoy2008-18925972,
  author  = {McCoy, M. K. and Tansey, M. G.},
  title   = {{TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-45},
  pmid    = {18925972},
  url     = {https://doi.org/10.1186/1742-2094-5-45}
}

@article{hauw1994-7969952,
  author  = {Hauw, J. J. and Daniel, S. E. and Dickson, D. and Horoupian, D. S. and Jellinger, K. and Lantos, P. L. and McKee, A. and Tabaton, M. and others},
  title   = {{Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy)}},
  journal = {Neurology},
  year    = {1994},
  doi     = {10.1212/wnl.44.11.2015},
  pmid    = {7969952},
  url     = {https://doi.org/10.1212/wnl.44.11.2015}
}

@article{pekny2016-26671410,
  author  = {Pekny, M. and Pekna, M. and Messing, A. and Steinhäuser, C. and Lee, J. M. and Parpura, V. and Hol, E. M. and Sofroniew, M. V. and others},
  title   = {{Astrocytes: a central element in neurological diseases}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-015-1513-1},
  pmid    = {26671410},
  url     = {https://doi.org/10.1007/s00401-015-1513-1}
}

@article{rogers1992-1438191,
  author  = {Rogers, J and Cooper, Neil R. and Webster, Scott D. and Schultz, J and McGeer, Patrick L. and Styren, Scot D. and CIVIN, W. HAROLD and Brachova, Libuse and others},
  title   = {{Complement activation by beta-amyloid in Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {1992},
  doi     = {10.1073/pnas.89.21.10016},
  pmid    = {1438191},
  url     = {https://doi.org/10.1073/pnas.89.21.10016}
}

@article{hofman1989-2754393,
  author  = {Hofman, Florence M. and Hinton, David R. and Johnson, K. P. and Merrill, J E},
  title   = {{Tumor necrosis factor identified in multiple sclerosis brain}},
  journal = {The Journal of Experimental Medicine},
  year    = {1989},
  doi     = {10.1084/jem.170.2.607},
  pmid    = {2754393},
  url     = {https://doi.org/10.1084/jem.170.2.607}
}

@article{cunningham2005-16207887,
  author  = {Cunningham, Colm M. and Wilcockson, David Charles and Campion, Suzanne and Lunnon, Katie and Perry, Victor Hugh},
  title   = {{Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration}},
  journal = {Journal of Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2614-05.2005},
  pmid    = {16207887},
  url     = {https://doi.org/10.1523/jneurosci.2614-05.2005}
}

@article{frankcannon2009-19917131,
  author  = {Frank-Cannon, Tamy C. and Alto, Laura Taylor and McAlpine, Fiona E and Tansey, Malú G.},
  title   = {{Does neuroinflammation fan the flame in neurodegenerative diseases?}},
  journal = {Molecular Neurodegeneration},
  year    = {2009},
  doi     = {10.1186/1750-1326-4-47},
  pmid    = {19917131},
  url     = {https://doi.org/10.1186/1750-1326-4-47}
}

@article{selmaj1991-1999503,
  author  = {Selmaj, Krzysztof W. and Raine, Cedric S. and Cannella, Barbara and Brosnan, Celia F.},
  title   = {{Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions}},
  journal = {Journal of Clinical Investigation},
  year    = {1991},
  doi     = {10.1172/jci115102},
  pmid    = {1999503},
  url     = {https://doi.org/10.1172/jci115102}
}

@article{combs2001-11160388,
  author  = {Combs, Colin Kelly and Karlo, J. Colleen and Kao, Shih-Chu and Landreth, Gary E.},
  title   = {{β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis}},
  journal = {Journal of Neuroscience},
  year    = {2001},
  doi     = {10.1523/jneurosci.21-04-01179.2001},
  pmid    = {11160388},
  url     = {https://doi.org/10.1523/jneurosci.21-04-01179.2001}
}

@article{fagiolo1993-8370415,
  author  = {Fagiolo, Umberto and Cossarizza, Andrea and Scala, Enrico and Fanales‐Belasio, Emanuele and Ortolani, Claudio and Cozzi, Emanuele and Monti, Daniela and Franceschi, Claudio and others},
  title   = {{Increased cytokine production in mononuclear cells of healthy elderly people}},
  journal = {European Journal of Immunology},
  year    = {1993},
  doi     = {10.1002/eji.1830230950},
  pmid    = {8370415},
  url     = {https://doi.org/10.1002/eji.1830230950}
}

@article{paresce1996-8816718,
  author  = {Paresce, Donata M. and Ghosh, Richik N. and Maxfield, Frederick R.},
  title   = {{Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor}},
  journal = {Neuron},
  year    = {1996},
  doi     = {10.1016/s0896-6273(00)80187-7},
  pmid    = {8816718},
  url     = {https://doi.org/10.1016/s0896-6273(00)80187-7}
}

@article{chiu2013-23850290,
  author  = {Chiu, Isaac M. and Morimoto, Emiko and Goodarzi, Hani and Liao, Jennifer T. and O’Keeffe, Sean and Phatnani, Hemali P. and Muratet, Michael A. and Carroll, Michael C. and others},
  title   = {{A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model}},
  journal = {Cell Reports},
  year    = {2013},
  doi     = {10.1016/j.celrep.2013.06.018},
  pmid    = {23850290},
  url     = {https://doi.org/10.1016/j.celrep.2013.06.018}
}

@article{benito2003-14657172,
  author  = {Benito, Cristina and Núñez, Estefanía and Tolón, Rosa Maria and Carrier, Erica J. and Rábano, Alberto and Hillard, Cecilia J. and Romero, Julián},
  title   = {{Cannabinoid CB2Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains}},
  journal = {Journal of Neuroscience},
  year    = {2003},
  doi     = {10.1523/jneurosci.23-35-11136.2003},
  pmid    = {14657172},
  url     = {https://doi.org/10.1523/jneurosci.23-35-11136.2003}
}

@article{frautschy1998-9422548,
  author  = {Frautschy, Sally Ann and Yang, F and Irrizarry, Michael and Hyman, Bradley T. and Saido, Takaomi C. and Hsiao, Karen and Cole, Greg M.},
  title   = {{Microglial response to amyloid plaques in APPsw transgenic mice}},
  journal = {Europe PMC (PubMed Central)},
  year    = {1998},
  pmid    = {9422548}
}

@article{lian2016-26758846,
  author  = {Lian, Hong and Litvinchuk, Alexandra and Chiang, Angie C.A. and Aithmitti, Nadia and Jankowsky, Joanna L. and Zheng, Hui},
  title   = {{Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease}},
  journal = {Journal of Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.2117-15.2016},
  pmid    = {26758846},
  url     = {https://doi.org/10.1523/jneurosci.2117-15.2016}
}

@article{reedgeaghan2009-19776284,
  author  = {Reed-Geaghan, Erin G. and Savage, Julie C. and Hise, Amy G. and Landreth, Gary E.},
  title   = {{CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation}},
  journal = {Journal of Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.3158-09.2009},
  pmid    = {19776284},
  url     = {https://doi.org/10.1523/jneurosci.3158-09.2009}
}

@article{akiyama2000-10850730,
  author  = {Akiyama, H. and Arai, T. and Kondo, H. and Tanno, E. and Haga, C. and Ikeda, K.},
  title   = {{Cell mediators of inflammation in the Alzheimer disease brain}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2000},
  doi     = {10.1097/00002093-200000001-00008},
  pmid    = {10850730},
  url     = {https://doi.org/10.1097/00002093-200000001-00008}
}

@article{nakamura2002-12186424,
  author  = {Nakamura, Y.},
  title   = {{Regulating factors for microglial activation}},
  journal = {Biological \& pharmaceutical bulletin},
  year    = {2002},
  doi     = {10.1248/bpb.25.945},
  pmid    = {12186424},
  url     = {https://doi.org/10.1248/bpb.25.945}
}

@article{norenberg1987-3306480,
  author  = {Norenberg, M. D.},
  title   = {{The role of astrocytes in hepatic encephalopathy}},
  journal = {Neurochemical pathology},
  year    = {1987},
  doi     = {10.1007/bf02833599},
  pmid    = {3306480},
  url     = {https://doi.org/10.1007/bf02833599}
}

@article{bamburg2016-26873625,
  author  = {Bamburg, JR. and Bernstein, B. W.},
  title   = {{Actin dynamics and cofilin-actin rods in alzheimer disease}},
  journal = {Cytoskeleton (Hoboken, N.J.)},
  year    = {2016},
  doi     = {10.1002/cm.21282},
  pmid    = {26873625},
  url     = {https://doi.org/10.1002/cm.21282}
}

@article{calderongarciduenas2015-25256239,
  author  = {Calderón-Garcidueñas, L. and Calderón-Garcidueñas, A. and Torres-Jardón, R. and Avila-Ramírez, J. and Kulesza, R. J. and Angiulli, A. D.},
  title   = {{Air pollution and your brain: what do you need to know right now}},
  journal = {Primary health care research \& development},
  year    = {2015},
  doi     = {10.1017/s146342361400036x},
  pmid    = {25256239},
  url     = {https://doi.org/10.1017/s146342361400036x}
}

@article{kakkar2025-40938771,
  author  = {Kakkar, A. K. and Singh, Harpreet and Singh, Bhuvnesh Kumar and Kumar, Arvind and Mishra, Arun Kumar and Chopra, Hitesh},
  title   = {{Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251374353},
  pmid    = {40938771},
  url     = {https://doi.org/10.1177/13872877251374353}
}

@article{zhao2025-40145977,
  author  = {Zhao, Wenhui and Liu, Zhongxuan and Wu, Jiannan and Liu, Anran and Yan, Junqiang},
  title   = {{Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications}},
  journal = {Neural Regeneration Research},
  year    = {2025},
  doi     = {10.4103/nrr.nrr-d-24-01343},
  pmid    = {40145977},
  url     = {https://doi.org/10.4103/nrr.nrr-d-24-01343}
}

@article{park2025-40771977,
  author  = {Park, Hyoungshin and Ni, Manting and Le, Yvonne},
  title   = {{Neuroinflammation and nutrition in Alzheimer’s disease}},
  journal = {Frontiers in Neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1622571},
  pmid    = {40771977},
  url     = {https://doi.org/10.3389/fneur.2025.1622571}
}

@article{mengr2025-39932627,
  author  = {Mengr, Anna and Šmotková, Zuzana and Pačesová, Andrea and Železná, Blanka and Kuneš, Jaroslav and Maletı́nská, Lenka},
  title   = {{Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease}},
  journal = {Journal of Neuroimmune Pharmacology},
  year    = {2025},
  doi     = {10.1007/s11481-025-10174-w},
  pmid    = {39932627},
  url     = {https://doi.org/10.1007/s11481-025-10174-w}
}

@article{boreland2025-41205777,
  author  = {Boreland, Andrew J. and Abbo, Yara and Li, Xindi and Stillitano, Alessandro C. and Zhang, Siwei and Duan, Jubao and Pang, Zhiping P. and Hart, Ronald P.},
  title   = {{Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model}},
  journal = {Alcohol},
  year    = {2025},
  doi     = {10.1016/j.alcohol.2025.10.006},
  pmid    = {41205777},
  url     = {https://doi.org/10.1016/j.alcohol.2025.10.006}
}

@article{villacampa2025-40387894,
  author  = {Villacampa, Nàdia and Sarlus, Heela and Martorell, Paula and Bhalla, Khushbu and Castro‐Gomez, Sergio and Vieira-Saecker, Ana Maria Menezes and Slutzkin, Ilya and Händler, Kristian and others},
  title   = {{Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease}},
  journal = {ASN NEURO},
  year    = {2025},
  doi     = {10.1080/17590914.2025.2506406},
  pmid    = {40387894},
  url     = {https://doi.org/10.1080/17590914.2025.2506406}
}

@article{nguyenhao2025-40581808,
  author  = {Nguyen-Hao, Hoang-Tuong and Liu, Jie and Novelli, Mario and Maskey, Dhiraj and Schwartz, Raymond S. and Harari, Oscar and Sutherland, Greg Trevor},
  title   = {{Quantification of Alzheimer disease neuropathology using tissue microarrays}},
  journal = {Journal of Neuropathology \& Experimental Neurology},
  year    = {2025},
  doi     = {10.1093/jnen/nlaf064},
  pmid    = {40581808},
  url     = {https://doi.org/10.1093/jnen/nlaf064}
}

@article{untu2025-40529210,
  author  = {Untu, Ilinca and Davidson, Michael and Stanciu, Gabriela Dumitriţa and Rabinowitz, Jonathan and Dobrin, Romeo and Vieru, Diana Sabina and Tamba, Bogdan-Ionel},
  title   = {{Neurobiological and therapeutic landmarks of depression associated with Alzheimer’s disease dementia}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1584607},
  pmid    = {40529210},
  url     = {https://doi.org/10.3389/fnagi.2025.1584607}
}

@article{kandimalla2026-41574776,
  author  = {Kandimalla, Mahathi and Lim, Seokbeen and Jacobson, David N and Lee, Jeyeon and Min, Paul H. and Nycklemoe, Marin and Lee, Seung Baek and Lundt, Emily S. and others},
  title   = {{Neuroinflammation demonstrated by 11 C‐ER176 PET with amyloid and tau pathology}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71027},
  pmid    = {41574776},
  url     = {https://doi.org/10.1002/alz.71027}
}

@article{liu2025-41013506,
  author  = {Liu, Jiahui and Zaidi, Ali Hussainy and Pike, Christian J.},
  title   = {{Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity in a sexually dimorphic manner}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03534-z},
  pmid    = {41013506},
  url     = {https://doi.org/10.1186/s12974-025-03534-z}
}

@article{abdellah2025-40325262,
  author  = {Abdel-Lah, Ebtsam S and Sherkawy, Hoda S. and Mohamed, Wafaa H. and Fawy, Mariam A. and Hasan, Asmaa A. and Muhammed, Asmaa A. and Taha, Amira F. and Tony, Abeer A. and others},
  title   = {{Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer’s disease in rats: role of AMPK/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress}},
  journal = {Inflammopharmacology},
  year    = {2025},
  doi     = {10.1007/s10787-025-01755-5},
  pmid    = {40325262},
  url     = {https://doi.org/10.1007/s10787-025-01755-5}
}

@article{beretti2025-41595595,
  author  = {Beretti, Francesca and Malenchini, Marta and Gatti, Martina and Maraldi, Tullia},
  title   = {{Oxidative Stress as a Central Mechanistic Bridge Between Alzheimer’s and Vascular Pathologies in Mixed Dementia: Emerging Evidence and Therapeutic Perspectives}},
  journal = {Biomedicines},
  year    = {2025},
  doi     = {10.3390/biomedicines14010059},
  pmid    = {41595595},
  url     = {https://doi.org/10.3390/biomedicines14010059}
}

@article{ciervo2026-41499526,
  author  = {Ciervo, Yuri and Rigoni, Pietro and Bucciarelli, Linda and Lombi, Martina and Pratesi, Federico and Bologna, Nadia and Accardo, Massimo and Recchi, Chiara and others},
  title   = {{Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice}},
  journal = {Science Translational Medicine},
  year    = {2026},
  doi     = {10.1126/scitranslmed.adw9930},
  pmid    = {41499526},
  url     = {https://doi.org/10.1126/scitranslmed.adw9930}
}

@article{mearelli2025-40888599,
  author  = {Mearelli, Marika and Hirschberg, Insa and Weissleder, Christin and Giachino, Carmela and Maria Jose Perez, J. and Dubroux, Malvina and Provenzano, Francesca and Rizzuti, Mafalda and others},
  title   = {{C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC ‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk}},
  journal = {Glia},
  year    = {2025},
  doi     = {10.1002/glia.70080},
  pmid    = {40888599},
  url     = {https://doi.org/10.1002/glia.70080}
}

@article{choe2025-41204331,
  author  = {Choe, Kyonghwan and Ahmad, Riaz and Kang, Min Hwa and Lee, Hyeon Jin and Ahmad, Sareer and Park, Tae Ju and Kim, Myeong Ok},
  title   = {{The novel sphingolipids cP1P and P1P attenuate neuroinflammation and enhance S1PR1/Akt/mTOR signaling to mitigate cognitive decline in an Alzheimer’s disease mouse model}},
  journal = {Cell Communication and Signaling},
  year    = {2025},
  doi     = {10.1186/s12964-025-02485-5},
  pmid    = {41204331},
  url     = {https://doi.org/10.1186/s12964-025-02485-5}
}

@article{harmouch2026-42215997,
  author  = {Harmouch, Jamile and Green, Ryan J. and Mayilsamy, Karthick and Tosi, Kristina and Mohapatra, Subhra and Mohapatra, Shyam S.},
  title   = {{Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD}},
  journal = {Journal of Neuroinflammation},
  year    = {2026},
  doi     = {10.1186/s12974-026-03876-2},
  pmid    = {42215997},
  url     = {https://doi.org/10.1186/s12974-026-03876-2}
}

@article{gonzalezperez2025-40494433,
  author  = {González Pérez, N. and Bellotto, M. and Porte Alcón, S. and Bentivegna, M. and Arcucci, L. and Á, Vinuesa and Presa, J. and Brites, F. and others},
  title   = {{Metformin protects against insulin resistance-related dementia risk involving restored microglial homeostasis}},
  journal = {Life sciences},
  year    = {2025},
  doi     = {10.1016/j.lfs.2025.123803},
  pmid    = {40494433},
  url     = {https://doi.org/10.1016/j.lfs.2025.123803}
}

@article{venegas2019-31702392,
  author  = {Venegas, Carmen and Heneka, Michael T},
  title   = {{Inflammasome-mediated innate immunity in Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900439},
  pmid    = {31702392},
  url     = {https://doi.org/10.1096/fj.201900439}
}

@article{shi2020-32804134,
  author  = {Shi, Jian-Quan and Wang, Bian-Rong and Jiang, Teng and Gao, Li and Zhang, Ying-Dong and Xu, Jun},
  title   = {{NLRP3 Inflammasome: A Potential Therapeutic Target in Fine Particulate Matter-Induced Neuroinflammation in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200359},
  pmid    = {32804134},
  url     = {https://doi.org/10.3233/jad-200359}
}

@article{pereira2019-31577960,
  author  = {Pereira, Claudia F and Santos, Armanda E and Moreira, Paula I and Pereira, Ana Catarina and Sousa, Fabio J and Cardoso, Sandra M and Cruz, M Teresa},
  title   = {{Is Alzheimer's disease an inflammasomopathy?}},
  journal = {Ageing research reviews},
  year    = {2019},
  doi     = {10.1016/j.arr.2019.100966},
  pmid    = {31577960},
  url     = {https://doi.org/10.1016/j.arr.2019.100966}
}

@article{heneka2017-28019679,
  author  = {Heneka, Michael T},
  title   = {{Inflammasome activation and innate immunity in Alzheimer's disease}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2017},
  doi     = {10.1111/bpa.12483},
  pmid    = {28019679},
  url     = {https://doi.org/10.1111/bpa.12483}
}

@article{giorgi2020-33207731,
  author  = {Giorgi, Filippo Sean and Biagioni, Francesca and Galgani, Alessandro and Pavese, Nicola and Lazzeri, Gloria and Fornai, Francesco},
  title   = {{Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21228630},
  pmid    = {33207731},
  url     = {https://doi.org/10.3390/ijms21228630}
}

@article{dinet2019-31780883,
  author  = {Dinet, Virginie and Petry, Klaus G and Badaut, Jerome},
  title   = {{Brain-Immune Interactions and Neuroinflammation After Traumatic Brain Injury}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.01178},
  pmid    = {31780883},
  url     = {https://doi.org/10.3389/fnins.2019.01178}
}

@article{ho2020-31786775,
  author  = {Ho, Wen-Chien and Hsu, Chia-Chi and Huang, Hui-Ju and Wang, Hsiang-Tsui and Lin, Anya Maan-Yuh},
  title   = {{Anti-inflammatory Effect of AZD6244 on Acrolein-Induced Neuroinflammation}},
  journal = {Molecular neurobiology},
  year    = {2020},
  doi     = {10.1007/s12035-019-01758-8},
  pmid    = {31786775},
  url     = {https://doi.org/10.1007/s12035-019-01758-8}
}

@article{tzeng2018-30127003,
  author  = {Tzeng, Te-Chen and Hasegawa, Yuto and Iguchi, Risa and Cheung, Amy and Caffrey, Daniel R and Thatcher, Elizabeth Jeanne and Mao, Wenjie and Germain, Gail and others},
  title   = {{Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2018},
  doi     = {10.1073/pnas.1801802115},
  pmid    = {30127003},
  url     = {https://doi.org/10.1073/pnas.1801802115}
}

@article{pennisi2017-27862176,
  author  = {Pennisi, Manuela and Crupi, Rosalia and Di Paola, Rosanna and Ontario, Maria Laura and Bella, Rita and Calabrese, Edward J and Crea, Roberto and Cuzzocrea, Salvatore and others},
  title   = {{Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease}},
  journal = {Journal of neuroscience research},
  year    = {2017},
  doi     = {10.1002/jnr.23986},
  pmid    = {27862176},
  url     = {https://doi.org/10.1002/jnr.23986}
}