% alzhub.org library filter % Source: https://alzhub.org/research?category=genetics_trem2&year=2017 % 46 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{sims2017-28714976, author = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others}, title = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}}, journal = {Nature genetics}, year = {2017}, doi = {10.1038/ng.3916}, pmid = {28714976}, url = {https://doi.org/10.1038/ng.3916} } @article{krasemann2017-28930663, author = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others}, title = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}}, journal = {Immunity}, year = {2017}, doi = {10.1016/j.immuni.2017.08.008}, pmid = {28930663}, url = {https://doi.org/10.1016/j.immuni.2017.08.008} } @article{kerenshaul2017-28602351, author = {Keren-Shaul, H. and Spinrad, A. and Weiner, A. and Matcovitch-Natan, O. and Dvir-Szternfeld, R. and Ulland, T. K. and David, E. and Baruch, K. and others}, title = {{A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease}}, journal = {Cell}, year = {2017}, doi = {10.1016/j.cell.2017.05.018}, pmid = {28602351}, url = {https://doi.org/10.1016/j.cell.2017.05.018} } @article{ulland2017-28802038, author = {Ulland, T. K. and Song, W. M. and Huang, S. C. and Ulrich, J. D. and Sergushichev, A. and Beatty, W. L. and Loboda, A. A. and Zhou, Y. and others}, title = {{TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease}}, journal = {Cell}, year = {2017}, doi = {10.1016/j.cell.2017.07.023}, pmid = {28802038}, url = {https://doi.org/10.1016/j.cell.2017.07.023} } @article{leyns2017-29073081, author = {Leyns, C. E. G. and Ulrich, J. D. and Finn, M. B. and Stewart, F. R. and Koscal, L. J. and Remolina Serrano, J. and Robinson, G. O. and Anderson, E. and others}, title = {{TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2017}, doi = {10.1073/pnas.1710311114}, pmid = {29073081}, url = {https://doi.org/10.1073/pnas.1710311114} } @article{kunkle2017-28738127, author = {Kunkle, B. W. and Vardarajan, B. N. and Naj, A. C. and Whitehead, P. L. and Rolati, S. and Slifer, S. and Carney, R. M. and Cuccaro, M. L. and others}, title = {{Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.1518}, pmid = {28738127}, url = {https://doi.org/10.1001/jamaneurol.2017.1518} } @article{jay2017-28100745, author = {Jay, T. R. and Hirsch, A. M. and Broihier, M. L. and Miller, C. M. and Neilson, L. E. and Ransohoff, R. M. and Lamb, B. T. and Landreth, G. E.}, title = {{Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2017}, doi = {10.1523/jneurosci.2110-16.2016}, pmid = {28100745}, url = {https://doi.org/10.1523/jneurosci.2110-16.2016} } @article{efthymiou2017-28549481, author = {Efthymiou, A. G. and Goate, A. M.}, title = {{Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk}}, journal = {Molecular neurodegeneration}, year = {2017}, doi = {10.1186/s13024-017-0184-x}, pmid = {28549481}, url = {https://doi.org/10.1186/s13024-017-0184-x} } @article{zhong2017-28209725, author = {Zhong, L. and Chen, X. F. and Wang, T. and Wang, Z. and Liao, C. and Huang, R. and Wang, D. and others}, title = {{Soluble TREM2 induces inflammatory responses and enhances microglial survival}}, journal = {The Journal of experimental medicine}, year = {2017}, doi = {10.1084/jem.20160844}, pmid = {28209725}, url = {https://doi.org/10.1084/jem.20160844} } @article{ulrich2017-28426958, author = {Ulrich, J. D. and Ulland, T. K. and Colonna, M. and Holtzman, D. M.}, title = {{Elucidating the Role of TREM2 in Alzheimer's Disease}}, journal = {Neuron}, year = {2017}, doi = {10.1016/j.neuron.2017.02.042}, pmid = {28426958}, url = {https://doi.org/10.1016/j.neuron.2017.02.042} } @article{jay2017-28768545, author = {Jay, T. R. and von Saucken, V. E. and Landreth, G. E.}, title = {{TREM2 in Neurodegenerative Diseases}}, journal = {Molecular neurodegeneration}, year = {2017}, doi = {10.1186/s13024-017-0197-5}, pmid = {28768545}, url = {https://doi.org/10.1186/s13024-017-0197-5} } @article{kleinberger2017-28559417, author = {Kleinberger, G. and Brendel, M. and Mracsko, E. and Wefers, B. and Groeneweg, L. and Xiang, X. and Focke, C. and Deußing, M. and others}, title = {{The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism}}, journal = {The EMBO journal}, year = {2017}, doi = {10.15252/embj.201796516}, pmid = {28559417}, url = {https://doi.org/10.15252/embj.201796516} } @article{zheng2017-28077724, author = {Zheng, H. and Jia, L. and Liu, C. C. and Rong, Z. and Zhong, L. and Yang, L. and Chen, X. F. and Fryer, J. D. and others}, title = {{TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2017}, doi = {10.1523/jneurosci.2459-16.2017}, pmid = {28077724}, url = {https://doi.org/10.1523/jneurosci.2459-16.2017} } @article{bemiller2017-29037207, author = {Bemiller, S. M. and McCray, T. J. and Allan, K. and Formica, S. V. and Xu, G. and Wilson, G. and Kokiko-Cochran, O. N. and Crish, S. D. and others}, title = {{TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy}}, journal = {Molecular neurodegeneration}, year = {2017}, doi = {10.1186/s13024-017-0216-6}, pmid = {29037207}, url = {https://doi.org/10.1186/s13024-017-0216-6} } @article{hauremirande2017-28612290, author = {Haure-Mirande, J. V. and Audrain, M. and Fanutza, T. and Kim, S. H. and Klein, W. L. and Glabe, C. and Readhead, B. and Dudley, J. T. and others}, title = {{Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology}}, journal = {Acta neuropathologica}, year = {2017}, doi = {10.1007/s00401-017-1737-3}, pmid = {28612290}, url = {https://doi.org/10.1007/s00401-017-1737-3} } @article{thornton2017-28855301, author = {Thornton, P. and Sevalle, J. and Deery, M. J. and Fraser, G. and Zhou, Y. and Ståhl, S. and Franssen, E. H. and Dodd, R. B. and others}, title = {{TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant}}, journal = {EMBO molecular medicine}, year = {2017}, doi = {10.15252/emmm.201707673}, pmid = {28855301}, url = {https://doi.org/10.15252/emmm.201707673} } @article{castillo2017-29259249, author = {Castillo, E. and Leon, J. and Mazzei, G. and Abolhassani, N. and Haruyama, N. and Saito, T. and Saido, T. and Hokama, M. and others}, title = {{Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation}}, journal = {Scientific reports}, year = {2017}, doi = {10.1038/s41598-017-17999-3}, pmid = {29259249}, url = {https://doi.org/10.1038/s41598-017-17999-3} } @article{yeh2017-28442216, author = {Yeh, F. L. and Hansen, D. V. and Sheng, M.}, title = {{TREM2, Microglia, and Neurodegenerative Diseases}}, journal = {Trends in molecular medicine}, year = {2017}, doi = {10.1016/j.molmed.2017.03.008}, pmid = {28442216}, url = {https://doi.org/10.1016/j.molmed.2017.03.008} } @article{feuerbach2017-28923481, author = {Feuerbach, D. and Schindler, P. and Barske, C. and Joller, S. and Beng-Louka, E. and Worringer, K. A. and Kommineni, S. and Kaykas, A. and others}, title = {{ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157}}, journal = {Neuroscience letters}, year = {2017}, doi = {10.1016/j.neulet.2017.09.034}, pmid = {28923481}, url = {https://doi.org/10.1016/j.neulet.2017.09.034} } @article{brendel2017-28197095, author = {Brendel, M. and Kleinberger, G. and Probst, F. and Jaworska, A. and Overhoff, F. and Blume, T. and Albert, N. L. and Carlsen, J. and others}, title = {{Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00008}, pmid = {28197095}, url = {https://doi.org/10.3389/fnagi.2017.00008} } @article{kober2017-28432014, author = {Kober, D. L. and Brett, T. J.}, title = {{TREM2-Ligand Interactions in Health and Disease}}, journal = {Journal of molecular biology}, year = {2017}, doi = {10.1016/j.jmb.2017.04.004}, pmid = {28432014}, url = {https://doi.org/10.1016/j.jmb.2017.04.004} } @article{yin2017-28434692, author = {Yin, Z. and Raj, D. and Saiepour, N. and Van Dam, D. and Brouwer, N. and Holtman, I. R. and Eggen, B. J. L. and Möller, T. and others}, title = {{Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease}}, journal = {Neurobiology of aging}, year = {2017}, doi = {10.1016/j.neurobiolaging.2017.03.021}, pmid = {28434692}, url = {https://doi.org/10.1016/j.neurobiolaging.2017.03.021} } @article{liao2017-27922847, author = {Liao, F. and Yoon, H. and Kim, J.}, title = {{Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease}}, journal = {Current opinion in lipidology}, year = {2017}, doi = {10.1097/mol.0000000000000383}, pmid = {27922847}, url = {https://doi.org/10.1097/mol.0000000000000383} } @article{takahashi2017-28070672, author = {Takahashi, H. and Klein, Z. A. and Bhagat, S. M. and Kaufman, A. C. and Kostylev, M. A. and Ikezu, T. and Strittmatter, S. M. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network}}, journal = {Acta neuropathologica}, year = {2017}, doi = {10.1007/s00401-017-1668-z}, pmid = {28070672}, url = {https://doi.org/10.1007/s00401-017-1668-z} } @article{fahrenhold2018-28987033, author = {Fahrenhold, M. and Rakic, S. and Classey, J. and Brayne, C. and Ince, P. G. and Nicoll, J. A. R. and Boche, D. and MRC-CFAS}, title = {{TREM2 expression in the human brain: a marker of monocyte recruitment?}}, journal = {Brain pathology (Zurich, Switzerland)}, year = {2018}, doi = {10.1111/bpa.12564}, pmid = {28987033}, url = {https://doi.org/10.1111/bpa.12564} } @article{wu2017-28592261, author = {Wu, R. and Li, X. and Xu, P. and Huang, L. and Cheng, J. and Huang, X. and Jiang, J. and Wu, L. J. and others}, title = {{TREM2 protects against cerebral ischemia/reperfusion injury}}, journal = {Molecular brain}, year = {2017}, doi = {10.1186/s13041-017-0296-9}, pmid = {28592261}, url = {https://doi.org/10.1186/s13041-017-0296-9} } @article{condello2018-29169609, author = {Condello, C. and Yuan, P. and Grutzendler, J.}, title = {{Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging}}, journal = {Biological psychiatry}, year = {2018}, doi = {10.1016/j.biopsych.2017.10.007}, pmid = {29169609}, url = {https://doi.org/10.1016/j.biopsych.2017.10.007} } @article{kim2017-28894284, author = {Kim, S. M. and Mun, B. R. and Lee, S. J. and Joh, Y. and Lee, H. Y. and Ji, K. Y. and Choi, H. R. and Lee, E. H. and others}, title = {{TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia}}, journal = {Scientific reports}, year = {2017}, doi = {10.1038/s41598-017-11634-x}, pmid = {28894284}, url = {https://doi.org/10.1038/s41598-017-11634-x} } @article{nam2017-28655926, author = {Nam, K. N. and Mounier, A. and Wolfe, C. M. and Fitz, N. F. and Carter, A. Y. and Castranio, E. L. and Kamboh, H. I. and Reeves, V. L. and others}, title = {{Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice}}, journal = {Scientific reports}, year = {2017}, doi = {10.1038/s41598-017-04412-2}, pmid = {28655926}, url = {https://doi.org/10.1038/s41598-017-04412-2} } @article{dardiotis2017-28214109, author = {Dardiotis, E. and Siokas, V. and Pantazi, E. and Dardioti, M. and Rikos, D. and Xiromerisiou, G. and Markou, A. and Papadimitriou, D. and others}, title = {{A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature}}, journal = {Neurobiology of aging}, year = {2017}, doi = {10.1016/j.neurobiolaging.2017.01.015}, pmid = {28214109}, url = {https://doi.org/10.1016/j.neurobiolaging.2017.01.015} } @article{clayton2017-29311768, author = {Clayton, K. A. and Van Enoo, A. A. and Ikezu, T.}, title = {{Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy}}, journal = {Frontiers in neuroscience}, year = {2017}, doi = {10.3389/fnins.2017.00680}, pmid = {29311768}, url = {https://doi.org/10.3389/fnins.2017.00680} } @article{piirainen2017-28185874, author = {Piirainen, S. and Youssef, A. and Song, C. and Kalueff, A. V. and Landreth, G. E. and Malm, T. and Tian, L.}, title = {{Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?}}, journal = {Neuroscience and biobehavioral reviews}, year = {2017}, doi = {10.1016/j.neubiorev.2017.01.046}, pmid = {28185874}, url = {https://doi.org/10.1016/j.neubiorev.2017.01.046} } @article{caldeira2017-28912710, author = {Caldeira, C. and Cunha, C. and Vaz, A. R. and Falcão, A. S. and Barateiro, A. and Seixas, E. and Fernandes, A. and Brites, D.}, title = {{Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00277}, pmid = {28912710}, url = {https://doi.org/10.3389/fnagi.2017.00277} } @article{jendresen2017-28320424, author = {Jendresen, C. and Årskog, V. and Daws, M. R. and Nilsson, L. N.}, title = {{The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway}}, journal = {Journal of neuroinflammation}, year = {2017}, doi = {10.1186/s12974-017-0835-4}, pmid = {28320424}, url = {https://doi.org/10.1186/s12974-017-0835-4} } @article{raha2017-27662313, author = {Raha, A. A. and Henderson, J. W. and Stott, SR. and Vuono, R. and Foscarin, S. and Friedland, R. P. and Zaman, S. H. and Raha-Chowdhury, R.}, title = {{Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-160663}, pmid = {27662313}, url = {https://doi.org/10.3233/jad-160663} } @article{cooperknock2017-28302159, author = {Cooper-Knock, J. and Green, C. and Altschuler, G. and Wei, W. and Bury, J. J. and Heath, P. R. and Wyles, M. and Gelsthorpe, C. and others}, title = {{A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis}}, journal = {Acta neuropathologica communications}, year = {2017}, doi = {10.1186/s40478-017-0424-x}, pmid = {28302159}, url = {https://doi.org/10.1186/s40478-017-0424-x} } @article{wyatt2017-28601603, author = {Wyatt, S. K. and Witt, T. and Barbaro, N. M. and Cohen-Gadol, A. A. and Brewster, A. L.}, title = {{Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy}}, journal = {Experimental neurology}, year = {2017}, doi = {10.1016/j.expneurol.2017.06.009}, pmid = {28601603}, url = {https://doi.org/10.1016/j.expneurol.2017.06.009} } @article{zhong2017-28680398, author = {Zhong, L. and Zhang, Z. L. and Li, X. and Liao, C. and Mou, P. and Wang, T. and Wang, Z. and others}, title = {{TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00204}, pmid = {28680398}, url = {https://doi.org/10.3389/fnagi.2017.00204} } @article{pinto2017-28567000, author = {Pinto, S. and Cunha, C. and Barbosa, M. and Vaz, A. R. and Brites, D.}, title = {{Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype}}, journal = {Frontiers in neuroscience}, year = {2017}, doi = {10.3389/fnins.2017.00273}, pmid = {28567000}, url = {https://doi.org/10.3389/fnins.2017.00273} } @article{hu2018-29051087, author = {Hu, L. Y. and Zhou, Y. and Cui, W. Q. and Hu, X. M. and Du, L. X. and Mi, W. L. and Chu, Y. X. and Wu, G. C. and others}, title = {{Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice}}, journal = {Brain, behavior, and immunity}, year = {2018}, doi = {10.1016/j.bbi.2017.10.011}, pmid = {29051087}, url = {https://doi.org/10.1016/j.bbi.2017.10.011} } @article{castranio2017-28502803, author = {Castranio, E. L. and Mounier, A. and Wolfe, C. M. and Nam, K. N. and Fitz, N. F. and Letronne, F. and Schug, J. and Koldamova, R. and others}, title = {{Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury}}, journal = {Neurobiology of disease}, year = {2017}, doi = {10.1016/j.nbd.2017.05.006}, pmid = {28502803}, url = {https://doi.org/10.1016/j.nbd.2017.05.006} } @article{ozaki2017-28412600, author = {Ozaki, Y. and Yoshino, Y. and Yamazaki, K. and Sao, T. and Mori, Y. and Ochi, S. and Yoshida, T. and Mori, T. and others}, title = {{DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease}}, journal = {Journal of psychiatric research}, year = {2017}, doi = {10.1016/j.jpsychires.2017.04.003}, pmid = {28412600}, url = {https://doi.org/10.1016/j.jpsychires.2017.04.003} } @article{zhang2018-29104108, author = {Zhang, X. and Wang, W. and Li, P. and Wang, X. and Ni, K.}, title = {{High TREM2 expression correlates with poor prognosis in gastric cancer}}, journal = {Human pathology}, year = {2018}, doi = {10.1016/j.humpath.2017.10.026}, pmid = {29104108}, url = {https://doi.org/10.1016/j.humpath.2017.10.026} } @article{zhang2017-29180839, author = {Zhang, Xiaobao and Yan, Fang and Cui, Jizheng and Wu, Yong and Luan, Hengfei and Yin, Miaomiao and Zhao, Zhibin and Feng, Jiying and others}, title = {{Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia}}, journal = {Mediators of inflammation}, year = {2017}, doi = {10.1155/2017/9340610}, pmid = {29180839}, url = {https://doi.org/10.1155/2017/9340610} } @article{gao2017-28393702, author = {Gao, Li and Jiang, Teng and Yao, Xiaoying and Yu, Ling and Yang, Xiaolan and Li, Yansheng}, title = {{TREM2 and the Progression of Alzheimer's Disease}}, journal = {Current neurovascular research}, year = {2017}, doi = {10.2174/1567202614666170404165201}, pmid = {28393702}, url = {https://doi.org/10.2174/1567202614666170404165201} } @article{carter2017-30480234, author = {Carter, C. J.}, title = {{Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer's Disease}}, journal = {Journal of Alzheimer's disease reports}, year = {2017}, doi = {10.3233/adr-170017}, pmid = {30480234}, url = {https://doi.org/10.3233/adr-170017} }