% alzhub.org library filter % Source: https://alzhub.org/research?category=genetics_trem2&institution=I4210113080 % 30 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{parhizkar2019-30617257, author = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others}, title = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-018-0296-9}, pmid = {30617257}, url = {https://doi.org/10.1038/s41593-018-0296-9} } @article{suarezcalvet2019-30630532, author = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others}, title = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-018-0301-5}, pmid = {30630532}, url = {https://doi.org/10.1186/s13024-018-0301-5} } @article{krasemann2017-28930663, author = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others}, title = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}}, journal = {Immunity}, year = {2017}, doi = {10.1016/j.immuni.2017.08.008}, pmid = {28930663}, url = {https://doi.org/10.1016/j.immuni.2017.08.008} } @article{franzmeier2020-33032659, author = {Franzmeier, N. and Suárez-Calvet, M. and Frontzkowski, L. and Moore, A. and Hohman, T. J. and Morenas-Rodriguez, E. and Nuscher, B. and Shaw, L. and others}, title = {{Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration}}, journal = {Molecular neurodegeneration}, year = {2020}, doi = {10.1186/s13024-020-00407-2}, pmid = {33032659}, url = {https://doi.org/10.1186/s13024-020-00407-2} } @article{suarezcalvet2016-26941262, author = {Suárez-Calvet, M. and Kleinberger, G. and MÁ, Araque Caballero and Brendel, M. and Rominger, A. and Alcolea, D. and Fortea, J. and Lleó, A. and others}, title = {{sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers}}, journal = {EMBO molecular medicine}, year = {2016}, doi = {10.15252/emmm.201506123}, pmid = {26941262}, url = {https://doi.org/10.15252/emmm.201506123} } @article{ewers2020-32790063, author = {Ewers, M. and Biechele, G. and Suárez-Calvet, M. and Sacher, C. and Blume, T. and Morenas-Rodriguez, E. and Deming, Y. and Piccio, L. and others}, title = {{Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation}}, journal = {EMBO molecular medicine}, year = {2020}, doi = {10.15252/emmm.202012308}, pmid = {32790063}, url = {https://doi.org/10.15252/emmm.202012308} } @article{xiang2021-34644146, author = {Xiang, X. and Wind, K. and Wiedemann, T. and Blume, T. and Shi, Y. and Briel, N. and Beyer, L. and Biechele, G. and others}, title = {{Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases}}, journal = {Science translational medicine}, year = {2021}, doi = {10.1126/scitranslmed.abe5640}, pmid = {34644146}, url = {https://doi.org/10.1126/scitranslmed.abe5640} } @article{biel2023-36620941, author = {Biel, D. and Suárez-Calvet, M. and Hager, P. and Rubinski, A. and Dewenter, A. and Steward, A. and Roemer, S. and Ewers, M. and others}, title = {{sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease}}, journal = {EMBO molecular medicine}, year = {2023}, doi = {10.15252/emmm.202216987}, pmid = {36620941}, url = {https://doi.org/10.15252/emmm.202216987} } @article{safaiyan2021-33606969, author = {Safaiyan, S. and Besson-Girard, S. and Kaya, T. and Cantuti-Castelvetri, L. and Liu, L. and Ji, H. and Schifferer, M. and Gouna, G. and others}, title = {{White matter aging drives microglial diversity}}, journal = {Neuron}, year = {2021}, doi = {10.1016/j.neuron.2021.01.027}, pmid = {33606969}, url = {https://doi.org/10.1016/j.neuron.2021.01.027} } @article{vanlengerich2023-36635496, author = {van Lengerich, B. and Zhan, L. and Xia, D. and Chan, D. and Joy, D. and Park, J. I. and Tatarakis, D. and Calvert, M. and others}, title = {{A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models}}, journal = {Nature neuroscience}, year = {2023}, doi = {10.1038/s41593-022-01240-0}, pmid = {36635496}, url = {https://doi.org/10.1038/s41593-022-01240-0} } @article{ma2018-30239611, author = {MÁ, Araque Caballero and Suárez-Calvet, M. and Duering, M. and Franzmeier, N. and Benzinger, T. and Fagan, A. M. and Bateman, R. J. and Jack, C. R. and others}, title = {{White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2018}, doi = {10.1093/brain/awy229}, pmid = {30239611}, url = {https://doi.org/10.1093/brain/awy229} } @article{schlepckow2020-32154671, author = {Schlepckow, K. and Monroe, K. M. and Kleinberger, G. and Cantuti-Castelvetri, L. and Parhizkar, S. and Xia, D. and Willem, M. and Werner, G. and others}, title = {{Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region}}, journal = {EMBO molecular medicine}, year = {2020}, doi = {10.15252/emmm.201911227}, pmid = {32154671}, url = {https://doi.org/10.15252/emmm.201911227} } @article{gouna2021-34424266, author = {Gouna, G. and Klose, C. and Bosch-Queralt, M. and Liu, L. and Gokce, O. and Schifferer, M. and Cantuti-Castelvetri, L. and Simons, M.}, title = {{TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination}}, journal = {The Journal of experimental medicine}, year = {2021}, doi = {10.1084/jem.20210227}, pmid = {34424266}, url = {https://doi.org/10.1084/jem.20210227} } @article{schlepckow2023-37863592, author = {Schlepckow, K. and Morenas-Rodríguez, E. and Hong, S. and Haass, C.}, title = {{Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease}}, journal = {The Lancet. Neurology}, year = {2023}, doi = {10.1016/s1474-4422(23)00247-8}, pmid = {37863592}, url = {https://doi.org/10.1016/s1474-4422(23)00247-8} } @article{kleinberger2017-28559417, author = {Kleinberger, G. and Brendel, M. and Mracsko, E. and Wefers, B. and Groeneweg, L. and Xiang, X. and Focke, C. and Deußing, M. and others}, title = {{The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism}}, journal = {The EMBO journal}, year = {2017}, doi = {10.15252/embj.201796516}, pmid = {28559417}, url = {https://doi.org/10.15252/embj.201796516} } @article{rauchmann2019-30458365, author = {Rauchmann, B. S. and Schneider-Axmann, T. and Alexopoulos, P. and Perneczky, R. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum}}, journal = {Neurobiology of aging}, year = {2019}, doi = {10.1016/j.neurobiolaging.2018.10.022}, pmid = {30458365}, url = {https://doi.org/10.1016/j.neurobiolaging.2018.10.022} } @article{lewcock2020-33096024, author = {Lewcock, J. W. and Schlepckow, K. and Di Paolo, G. and Tahirovic, S. and Monroe, K. M. and Haass, C.}, title = {{Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease}}, journal = {Neuron}, year = {2020}, doi = {10.1016/j.neuron.2020.09.029}, pmid = {33096024}, url = {https://doi.org/10.1016/j.neuron.2020.09.029} } @article{gotzl2019-31122931, author = {Götzl, J. K. and Brendel, M. and Werner, G. and Parhizkar, S. and Sebastian Monasor, L. and Kleinberger, G. and Colombo, A. V. and Deussing, M. and others}, title = {{Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism}}, journal = {EMBO molecular medicine}, year = {2019}, doi = {10.15252/emmm.201809711}, pmid = {31122931}, url = {https://doi.org/10.15252/emmm.201809711} } @article{gispert2016-27423963, author = {Gispert, J. D. and Suárez-Calvet, M. and Monté, G. C. and Tucholka, A. and Falcon, C. and Rojas, S. and Rami, L. and Sánchez-Valle, R. and others}, title = {{Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2016}, doi = {10.1016/j.jalz.2016.06.005}, pmid = {27423963}, url = {https://doi.org/10.1016/j.jalz.2016.06.005} } @article{reifschneider2022-35019161, author = {Reifschneider, A. and Robinson, S. and van Lengerich, B. and Gnörich, J. and Logan, T. and Heindl, S. and Vogt, M. A. and Weidinger, E. and others}, title = {{Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency}}, journal = {The EMBO journal}, year = {2022}, doi = {10.15252/embj.2021109108}, pmid = {35019161}, url = {https://doi.org/10.15252/embj.2021109108} } @article{yu2024-38289348, author = {Yu, C. and Lad, E. M. and Mathew, R. and Shiraki, N. and Littleton, S. and Chen, Y. and Hou, J. and Schlepckow, K. and others}, title = {{Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2}}, journal = {The Journal of experimental medicine}, year = {2024}, doi = {10.1084/jem.20231011}, pmid = {38289348}, url = {https://doi.org/10.1084/jem.20231011} } @article{piollet2024-38974464, author = {Piollet, M. and Porsch, F. and Rizzo, G. and Kapser, F. and Schulz, D. J. J. and Kiss, M. G. and Schlepckow, K. and Morenas-Rodriguez, E. and others}, title = {{TREM2 protects from atherosclerosis by limiting necrotic core formation}}, journal = {Nature cardiovascular research}, year = {2024}, doi = {10.1038/s44161-024-00429-9}, pmid = {38974464}, url = {https://doi.org/10.1038/s44161-024-00429-9} } @article{brendel2017-28197095, author = {Brendel, M. and Kleinberger, G. and Probst, F. and Jaworska, A. and Overhoff, F. and Blume, T. and Albert, N. L. and Carlsen, J. and others}, title = {{Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00008}, pmid = {28197095}, url = {https://doi.org/10.3389/fnagi.2017.00008} } @article{guner2020-32616437, author = {Güner, G. and Lichtenthaler, S. F.}, title = {{The substrate repertoire of γ-secretase/presenilin}}, journal = {Seminars in cell \& developmental biology}, year = {2020}, doi = {10.1016/j.semcdb.2020.05.019}, pmid = {32616437}, url = {https://doi.org/10.1016/j.semcdb.2020.05.019} } @article{xiang2016-27402340, author = {Xiang, X. and Werner, G. and Bohrmann, B. and Liesz, A. and Mazaheri, F. and Capell, A. and Feederle, R. and Knuesel, I. and others}, title = {{TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance}}, journal = {EMBO molecular medicine}, year = {2016}, doi = {10.15252/emmm.201606370}, pmid = {27402340}, url = {https://doi.org/10.15252/emmm.201606370} } @article{suarezcalvet2018-30482868, author = {Suárez-Calvet, M. and Capell, A. and MÁ, Araque Caballero and Morenas-Rodríguez, E. and Fellerer, K. and Franzmeier, N. and Kleinberger, G. and Eren, E. and others}, title = {{CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline}}, journal = {EMBO molecular medicine}, year = {2018}, doi = {10.15252/emmm.201809712}, pmid = {30482868}, url = {https://doi.org/10.15252/emmm.201809712} } @article{takalo2020-32917267, author = {Takalo, M. and Wittrahm, R. and Wefers, B. and Parhizkar, S. and Jokivarsi, K. and Kuulasmaa, T. and Mäkinen, P. and Martiskainen, H. and others}, title = {{The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions}}, journal = {Molecular neurodegeneration}, year = {2020}, doi = {10.1186/s13024-020-00402-7}, pmid = {32917267}, url = {https://doi.org/10.1186/s13024-020-00402-7} } @article{boschqueralt2021-33619376, author = {Bosch-Queralt, M. and Cantuti-Castelvetri, L. and Damkou, A. and Schifferer, M. and Schlepckow, K. and Alexopoulos, I. and Lütjohann, D. and Klose, C. and others}, title = {{Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination}}, journal = {Nature metabolism}, year = {2021}, doi = {10.1038/s42255-021-00341-7}, pmid = {33619376}, url = {https://doi.org/10.1038/s42255-021-00341-7} } @article{rauchmann2020-31958095, author = {Rauchmann, B. S. and Sadlon, A. and Perneczky, R. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2020}, doi = {10.3233/jad-191120}, pmid = {31958095}, url = {https://doi.org/10.3233/jad-191120} } @article{lichtenthaler2022-34689040, author = {Lichtenthaler, S. F. and Tschirner, S. K. and Steiner, H.}, title = {{Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2}}, journal = {Current opinion in neurobiology}, year = {2022}, doi = {10.1016/j.conb.2021.09.003}, pmid = {34689040}, url = {https://doi.org/10.1016/j.conb.2021.09.003} }