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% Source: https://alzhub.org/research?category=genetics_trem2
% 500 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{guerreiro2013-23150934,
  author  = {Guerreiro, R. and Wojtas, A. and Bras, J. and Carrasquillo, M. and Rogaeva, E. and Majounie, E. and Cruchaga, C. and Sassi, C. and others},
  title   = {{TREM2 variants in Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2013},
  doi     = {10.1056/nejmoa1211851},
  pmid    = {23150934},
  url     = {https://doi.org/10.1056/nejmoa1211851}
}

@article{sims2017-28714976,
  author  = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others},
  title   = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2017},
  doi     = {10.1038/ng.3916},
  pmid    = {28714976},
  url     = {https://doi.org/10.1038/ng.3916}
}

@article{pereira2021-34259835,
  author  = {Pereira, J. B. and Janelidze, S. and Smith, R. and Mattsson-Carlgren, N. and Palmqvist, S. and Teunissen, C. E. and Zetterberg, H. and Stomrud, E. and others},
  title   = {{Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awab223},
  pmid    = {34259835},
  url     = {https://doi.org/10.1093/brain/awab223}
}

@article{pascoal2021-34446931,
  author  = {Pascoal, T. A. and Benedet, A. L. and Ashton, N. J. and Kang, M. S. and Therriault, J. and Chamoun, M. and Savard, M. and Lussier, F. Z. and others},
  title   = {{Microglial activation and tau propagate jointly across Braak stages}},
  journal = {Nature medicine},
  year    = {2021},
  doi     = {10.1038/s41591-021-01456-w},
  pmid    = {34446931},
  url     = {https://doi.org/10.1038/s41591-021-01456-w}
}

@article{rajabli2025-40676597,
  author  = {Rajabli, F. and Benchek, P. and Tosto, G. and Kushch, N. and Sha, J. and Bazemore, K. and Zhu, C. and Lee, W. P. and others},
  title   = {{Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease}},
  journal = {Genome biology},
  year    = {2025},
  doi     = {10.1186/s13059-025-03564-z},
  pmid    = {40676597},
  url     = {https://doi.org/10.1186/s13059-025-03564-z}
}

@article{lill2015-25936935,
  author  = {Lill, C. M. and Rengmark, A. and Pihlstrøm, L. and Fogh, I. and Shatunov, A. and Sleiman, P. M. and Wang, L. S. and Liu, T. and others},
  title   = {{The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.12.009},
  pmid    = {25936935},
  url     = {https://doi.org/10.1016/j.jalz.2014.12.009}
}

@article{jonsson2013-23150908,
  author  = {Jonsson, T. and Stefansson, H. and Steinberg, S. and Jonsdottir, I. and Jonsson, P. V. and Snaedal, J. and Bjornsson, S. and Huttenlocher, J. and others},
  title   = {{Variant of TREM2 associated with the risk of Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2013},
  doi     = {10.1056/nejmoa1211103},
  pmid    = {23150908},
  url     = {https://doi.org/10.1056/nejmoa1211103}
}

@article{ruiz2014-24041969,
  author  = {Ruiz, A. and Dols-Icardo, O. and Bullido, M. J. and Pastor, P. and Rodríguez-Rodríguez, E. and López de Munain, A. and de Pancorbo, M. M. and Pérez-Tur, J. and others},
  title   = {{Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.08.011},
  pmid    = {24041969},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.08.011}
}

@article{hampel2020-32296418,
  author  = {Hampel, H. and Caraci, F. and Cuello, A. C. and Caruso, G. and Nisticò, R. and Corbo, M. and Baldacci, F. and Toschi, N. and others},
  title   = {{A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.00456},
  pmid    = {32296418},
  url     = {https://doi.org/10.3389/fimmu.2020.00456}
}

@article{parhizkar2019-30617257,
  author  = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others},
  title   = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-018-0296-9},
  pmid    = {30617257},
  url     = {https://doi.org/10.1038/s41593-018-0296-9}
}

@article{long2024-39444037,
  author  = {Long, H. and Simmons, A. and Mayorga, A. and Burgess, B. and Nguyen, T. and Budda, B. and Rychkova, A. and Rhinn, H. and others},
  title   = {{Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01599-1},
  pmid    = {39444037},
  url     = {https://doi.org/10.1186/s13195-024-01599-1}
}

@article{zernecke2020-32673538,
  author  = {Zernecke, A. and Winkels, H. and Cochain, C. and Williams, J. W. and Wolf, D. and Soehnlein, O. and Robbins, C. S. and Monaco, C. and others},
  title   = {{Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas}},
  journal = {Circulation research},
  year    = {2020},
  doi     = {10.1161/circresaha.120.316903},
  pmid    = {32673538},
  url     = {https://doi.org/10.1161/circresaha.120.316903}
}

@article{rikos2024-36408688,
  author  = {Rikos, D. and Siokas, V. and Mentis, A. A. and Aloizou, A. M. and Liampas, I. and Tsouris, Z. and Peristeri, E. and Stamati, P. and others},
  title   = {{TREM2 R47H variant and risk for Alzheimer's disease: assessment in a Greek population and updated meta-analysis}},
  journal = {The International journal of neuroscience},
  year    = {2024},
  doi     = {10.1080/00207454.2022.2150844},
  pmid    = {36408688},
  url     = {https://doi.org/10.1080/00207454.2022.2150844}
}

@article{nabizadeh2024-38961148,
  author  = {Nabizadeh, Fardin and Seyedmirzaei, Homa and Karami, Shaghayegh},
  title   = {{Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study}},
  journal = {Scientific reports},
  year    = {2024},
  doi     = {10.1038/s41598-024-66211-w},
  pmid    = {38961148},
  url     = {https://doi.org/10.1038/s41598-024-66211-w}
}

@article{suarezcalvet2019-30630532,
  author  = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others},
  title   = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-018-0301-5},
  pmid    = {30630532},
  url     = {https://doi.org/10.1186/s13024-018-0301-5}
}

@article{benitez2014-24439484,
  author  = {Benitez, B. A. and Jin, S. C. and Guerreiro, R. and Graham, R. and Lord, J. and Harold, D. and Sims, R. and Lambert, J. C. and others},
  title   = {{Missense variant in TREML2 protects against Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.12.010},
  pmid    = {24439484},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.12.010}
}

@article{carrasquillo2017-27939925,
  author  = {Carrasquillo, M. M. and Allen, M. and Burgess, J. D. and Wang, X. and Strickland, S. L. and Aryal, S. and Siuda, J. and Kachadoorian, M. L. and others},
  title   = {{A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.10.005},
  pmid    = {27939925},
  url     = {https://doi.org/10.1016/j.jalz.2016.10.005}
}

@article{liu2025-40507855,
  author  = {Liu, X. and Baxley, S. and Hebron, M. and Turner, R. S. and Moussa, C.},
  title   = {{Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26115044},
  pmid    = {40507855},
  url     = {https://doi.org/10.3390/ijms26115044}
}

@article{jin2015-25886450,
  author  = {Jin, S. C. and Carrasquillo, M. M. and Benitez, B. A. and Skorupa, T. and Carrell, D. and Patel, D. and Lincoln, S. and Krishnan, S. and others},
  title   = {{TREM2 is associated with increased risk for Alzheimer's disease in African Americans}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0016-9},
  pmid    = {25886450},
  url     = {https://doi.org/10.1186/s13024-015-0016-9}
}

@article{kleineidam2020-32166339,
  author  = {Kleineidam, L. and Chouraki, V. and Próchnicki, T. and van der Lee, S. J. and Madrid-Márquez, L. and Wagner-Thelen, H. and Karaca, I. and Weinhold, L. and others},
  title   = {{PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02138-6},
  pmid    = {32166339},
  url     = {https://doi.org/10.1007/s00401-020-02138-6}
}

@article{liu2016-26365049,
  author  = {Liu, G. and Liu, Y. and Jiang, Q. and Jiang, Y. and Feng, R. and Zhang, L. and Chen, Z. and Li, K. and others},
  title   = {{Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility}},
  journal = {Molecular neurobiology},
  year    = {2016},
  doi     = {10.1007/s12035-015-9416-7},
  pmid    = {26365049},
  url     = {https://doi.org/10.1007/s12035-015-9416-7}
}

@article{zhou2020-31932797,
  author  = {Zhou, Y. and Song, W. M. and Andhey, P. S. and Swain, A. and Levy, T. and Miller, K. R. and Poliani, P. L. and Cominelli, M. and others},
  title   = {{Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2020},
  doi     = {10.1038/s41591-019-0695-9},
  pmid    = {31932797},
  url     = {https://doi.org/10.1038/s41591-019-0695-9}
}

@article{hooli2014-25186855,
  author  = {Hooli, B. V. and Parrado, A. R. and Mullin, K. and Yip, W. K. and Liu, T. and Roehr, J. T. and Qiao, D. and Jessen, F. and others},
  title   = {{The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000855},
  pmid    = {25186855},
  url     = {https://doi.org/10.1212/wnl.0000000000000855}
}

@article{ramachandran2019-31597160,
  author  = {Ramachandran, P. and Dobie, R. and Wilson-Kanamori, JR. and Dora, E. F. and Henderson, B. E. P. and Luu, N. T. and Portman, JR. and Matchett, K. P. and others},
  title   = {{Resolving the fibrotic niche of human liver cirrhosis at single-cell level}},
  journal = {Nature},
  year    = {2019},
  doi     = {10.1038/s41586-019-1631-3},
  pmid    = {31597160},
  url     = {https://doi.org/10.1038/s41586-019-1631-3}
}

@article{tijms2024-38195725,
  author  = {Tijms, B. M. and Vromen, E. M. and Mjaavatten, O. and Holstege, H. and Reus, L. M. and van der Lee, S. and Wesenhagen, K. E. J. and Lorenzini, L. and others},
  title   = {{Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles}},
  journal = {Nature aging},
  year    = {2024},
  doi     = {10.1038/s43587-023-00550-7},
  pmid    = {38195725},
  url     = {https://doi.org/10.1038/s43587-023-00550-7}
}

@article{cuyvers2014-24119542,
  author  = {Cuyvers, E. and Bettens, K. and Philtjens, S. and Van Langenhove, T. and Gijselinck, I. and van der Zee, J. and Engelborghs, S. and Vandenbulcke, M. and others},
  title   = {{Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.09.009},
  pmid    = {24119542},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.09.009}
}

@article{li2015-26202100,
  author  = {Li, X. and Long, J. and He, T. and Belshaw, R. and Scott, J.},
  title   = {{Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2015},
  doi     = {10.1038/srep12393},
  pmid    = {26202100},
  url     = {https://doi.org/10.1038/srep12393}
}

@article{engelman2014-24378087,
  author  = {Engelman, Corinne D and Koscik, Rebecca L and Jonaitis, Erin M and Hermann, Bruce P and La Rue, Asenath and Sager, Mark A},
  title   = {{Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.11.013},
  pmid    = {24378087},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.11.013}
}

@article{krasemann2017-28930663,
  author  = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others},
  title   = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}},
  journal = {Immunity},
  year    = {2017},
  doi     = {10.1016/j.immuni.2017.08.008},
  pmid    = {28930663},
  url     = {https://doi.org/10.1016/j.immuni.2017.08.008}
}

@article{liu2018-30171911,
  author  = {Liu, D. and Cao, B. and Zhao, Y. and Huang, H. and McIntyre, R. S. and Rosenblat, J. D. and Zhou, H.},
  title   = {{Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis}},
  journal = {Neuroscience letters},
  year    = {2018},
  doi     = {10.1016/j.neulet.2018.08.038},
  pmid    = {30171911},
  url     = {https://doi.org/10.1016/j.neulet.2018.08.038}
}

@article{zhou2019-30883352,
  author  = {Zhou, S. L. and Tan, C. C. and Hou, X. H. and Cao, X. P. and Tan, L. and Yu, J. T.},
  title   = {{TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-181038},
  pmid    = {30883352},
  url     = {https://doi.org/10.3233/jad-181038}
}

@article{wang2015-25728668,
  author  = {Wang, Y. and Cella, M. and Mallinson, K. and Ulrich, J. D. and Young, K. L. and Robinette, M. L. and Gilfillan, S. and Krishnan, G. M. and others},
  title   = {{TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model}},
  journal = {Cell},
  year    = {2015},
  doi     = {10.1016/j.cell.2015.01.049},
  pmid    = {25728668},
  url     = {https://doi.org/10.1016/j.cell.2015.01.049}
}

@article{molinuevo2018-30488277,
  author  = {Molinuevo, J. L. and Ayton, S. and Batrla, R. and Bednar, M. M. and Bittner, T. and Cummings, J. and Fagan, A. M. and Hampel, H. and others},
  title   = {{Current state of Alzheimer's fluid biomarkers}},
  journal = {Acta neuropathologica},
  year    = {2018},
  doi     = {10.1007/s00401-018-1932-x},
  pmid    = {30488277},
  url     = {https://doi.org/10.1007/s00401-018-1932-x}
}

@article{garciaalonso2022-35794482,
  author  = {Garcia-Alonso, L. and Lorenzi, V. and Mazzeo, C. I. and Alves-Lopes, J. P. and Roberts, K. and Sancho-Serra, C. and Engelbert, J. and Marečková, M. and others},
  title   = {{Single-cell roadmap of human gonadal development}},
  journal = {Nature},
  year    = {2022},
  doi     = {10.1038/s41586-022-04918-4},
  pmid    = {35794482},
  url     = {https://doi.org/10.1038/s41586-022-04918-4}
}

@article{franzmeier2020-33032659,
  author  = {Franzmeier, N. and Suárez-Calvet, M. and Frontzkowski, L. and Moore, A. and Hohman, T. J. and Morenas-Rodriguez, E. and Nuscher, B. and Shaw, L. and others},
  title   = {{Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00407-2},
  pmid    = {33032659},
  url     = {https://doi.org/10.1186/s13024-020-00407-2}
}

@article{kerenshaul2017-28602351,
  author  = {Keren-Shaul, H. and Spinrad, A. and Weiner, A. and Matcovitch-Natan, O. and Dvir-Szternfeld, R. and Ulland, T. K. and David, E. and Baruch, K. and others},
  title   = {{A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease}},
  journal = {Cell},
  year    = {2017},
  doi     = {10.1016/j.cell.2017.05.018},
  pmid    = {28602351},
  url     = {https://doi.org/10.1016/j.cell.2017.05.018}
}

@article{jaitin2019-31257031,
  author  = {Jaitin, D. A. and Adlung, L. and Thaiss, C. A. and Weiner, A. and Li, B. and Descamps, H. and Lundgren, P. and Bleriot, C. and others},
  title   = {{Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner}},
  journal = {Cell},
  year    = {2019},
  doi     = {10.1016/j.cell.2019.05.054},
  pmid    = {31257031},
  url     = {https://doi.org/10.1016/j.cell.2019.05.054}
}

@article{wang2020-32579671,
  author  = {Wang, S. and Mustafa, M. and Yuede, C. M. and Salazar, S. V. and Kong, P. and Long, H. and Ward, M. and Siddiqui, O. and others},
  title   = {{Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model}},
  journal = {The Journal of experimental medicine},
  year    = {2020},
  doi     = {10.1084/jem.20200785},
  pmid    = {32579671},
  url     = {https://doi.org/10.1084/jem.20200785}
}

@article{dalmasso2019-30705288,
  author  = {Dalmasso, M. C. and Brusco, L. I. and Olivar, N. and Muchnik, C. and Hanses, C. and Milz, E. and Becker, J. and Heilmann-Heimbach, S. and others},
  title   = {{Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease}},
  journal = {Translational psychiatry},
  year    = {2019},
  doi     = {10.1038/s41398-019-0394-9},
  pmid    = {30705288},
  url     = {https://doi.org/10.1038/s41398-019-0394-9}
}

@article{bartl2021-34618817,
  author  = {Bartl, M. and Dakna, M. and Galasko, D. and Hutten, S. J. and Foroud, T. and Quan, M. and Marek, K. and Siderowf, A. and others},
  title   = {{Biomarkers of neurodegeneration and glial activation validated in Alzheimer's disease assessed in longitudinal cerebrospinal fluid samples of Parkinson's disease}},
  journal = {PloS one},
  year    = {2021},
  doi     = {10.1371/journal.pone.0257372},
  pmid    = {34618817},
  url     = {https://doi.org/10.1371/journal.pone.0257372}
}

@article{wang2016-27091843,
  author  = {Wang, Y. and Ulland, T. K. and Ulrich, J. D. and Song, W. and Tzaferis, J. A. and Hole, J. T. and Yuan, P. and Mahan, T. E. and others},
  title   = {{TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques}},
  journal = {The Journal of experimental medicine},
  year    = {2016},
  doi     = {10.1084/jem.20151948},
  pmid    = {27091843},
  url     = {https://doi.org/10.1084/jem.20151948}
}

@article{suarezcalvet2016-26941262,
  author  = {Suárez-Calvet, M. and Kleinberger, G. and MÁ, Araque Caballero and Brendel, M. and Rominger, A. and Alcolea, D. and Fortea, J. and Lleó, A. and others},
  title   = {{sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201506123},
  pmid    = {26941262},
  url     = {https://doi.org/10.15252/emmm.201506123}
}

@article{heslegrave2016-26754172,
  author  = {Heslegrave, A. and Heywood, W. and Paterson, R. and Magdalinou, N. and Svensson, J. and Johansson, P. and Öhrfelt, A. and Blennow, K. and others},
  title   = {{Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0071-x},
  pmid    = {26754172},
  url     = {https://doi.org/10.1186/s13024-016-0071-x}
}

@article{ewers2020-32790063,
  author  = {Ewers, M. and Biechele, G. and Suárez-Calvet, M. and Sacher, C. and Blume, T. and Morenas-Rodriguez, E. and Deming, Y. and Piccio, L. and others},
  title   = {{Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation}},
  journal = {EMBO molecular medicine},
  year    = {2020},
  doi     = {10.15252/emmm.202012308},
  pmid    = {32790063},
  url     = {https://doi.org/10.15252/emmm.202012308}
}

@article{pereira2022-37118533,
  author  = {Pereira, J. B. and Janelidze, S. and Strandberg, O. and Whelan, C. D. and Zetterberg, H. and Blennow, K. and Palmqvist, S. and Stomrud, E. and others},
  title   = {{Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology}},
  journal = {Nature aging},
  year    = {2022},
  doi     = {10.1038/s43587-022-00310-z},
  pmid    = {37118533},
  url     = {https://doi.org/10.1038/s43587-022-00310-z}
}

@article{ulland2017-28802038,
  author  = {Ulland, T. K. and Song, W. M. and Huang, S. C. and Ulrich, J. D. and Sergushichev, A. and Beatty, W. L. and Loboda, A. A. and Zhou, Y. and others},
  title   = {{TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease}},
  journal = {Cell},
  year    = {2017},
  doi     = {10.1016/j.cell.2017.07.023},
  pmid    = {28802038},
  url     = {https://doi.org/10.1016/j.cell.2017.07.023}
}

@article{alivernini2020-32601335,
  author  = {Alivernini, S. and MacDonald, L. and Elmesmari, A. and Finlay, S. and Tolusso, B. and Gigante, M. R. and Petricca, L. and Di Mario, C. and others},
  title   = {{Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis}},
  journal = {Nature medicine},
  year    = {2020},
  doi     = {10.1038/s41591-020-0939-8},
  pmid    = {32601335},
  url     = {https://doi.org/10.1038/s41591-020-0939-8}
}

@article{obradovic2021-34019793,
  author  = {Obradovic, A. and Chowdhury, N. and Haake, S. M. and Ager, C. and Wang, V. and Vlahos, L. and Guo, X. V. and Aggen, D. H. and others},
  title   = {{Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages}},
  journal = {Cell},
  year    = {2021},
  doi     = {10.1016/j.cell.2021.04.038},
  pmid    = {34019793},
  url     = {https://doi.org/10.1016/j.cell.2021.04.038}
}

@article{leyns2019-31235932,
  author  = {Leyns, C. E. G. and Gratuze, M. and Narasimhan, S. and Jain, N. and Koscal, L. J. and Jiang, H. and Manis, M. and Colonna, M. and others},
  title   = {{TREM2 function impedes tau seeding in neuritic plaques}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0433-0},
  pmid    = {31235932},
  url     = {https://doi.org/10.1038/s41593-019-0433-0}
}

@article{mancuso2024-38539015,
  author  = {Mancuso, R. and Fattorelli, N. and Martinez-Muriana, A. and Davis, E. and Wolfs, L. and Van Den Daele, J. and Geric, I. and Premereur, J. and others},
  title   = {{Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology}},
  journal = {Nature neuroscience},
  year    = {2024},
  doi     = {10.1038/s41593-024-01600-y},
  pmid    = {38539015},
  url     = {https://doi.org/10.1038/s41593-024-01600-y}
}

@article{wilson2020-32065223,
  author  = {Wilson, E. N. and Swarovski, M. S. and Linortner, P. and Shahid, M. and Zuckerman, A. J. and Wang, Q. and Channappa, D. and Minhas, P. S. and others},
  title   = {{Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awaa021},
  pmid    = {32065223},
  url     = {https://doi.org/10.1093/brain/awaa021}
}

@article{wijeyekoon2020-32006615,
  author  = {Wijeyekoon, R. S. and Kronenberg-Versteeg, D. and Scott, K. M. and Hayat, S. and Kuan, W. L. and Evans, JR. and Breen, D. P. and Cummins, G. and others},
  title   = {{Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease}},
  journal = {Brain, behavior, and immunity},
  year    = {2020},
  doi     = {10.1016/j.bbi.2020.01.018},
  pmid    = {32006615},
  url     = {https://doi.org/10.1016/j.bbi.2020.01.018}
}

@article{cappuyns2025-39709141,
  author  = {Cappuyns, S. and Piqué-Gili, M. and Esteban-Fabró, R. and Philips, G. and Balaseviciute, U. and Pinyol, R. and Gris-Oliver, A. and Vandecaveye, V. and others},
  title   = {{Single-cell RNA sequencing-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma}},
  journal = {Journal of hepatology},
  year    = {2025},
  doi     = {10.1016/j.jhep.2024.12.016},
  pmid    = {39709141},
  url     = {https://doi.org/10.1016/j.jhep.2024.12.016}
}

@article{wang2024-38172904,
  author  = {Wang, L. and Nykänen, N. P. and Western, D. and Gorijala, P. and Timsina, J. and Li, F. and Wang, Z. and Ali, M. and others},
  title   = {{Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-023-00687-4},
  pmid    = {38172904},
  url     = {https://doi.org/10.1186/s13024-023-00687-4}
}

@article{gouilly2025-41287056,
  author  = {Gouilly, D. and Da-Costa, A. and Vrillon, A. and Pistono, A. and Goubeaud, M. and Bertrand, E. and Germain, J. and Ainaoui, N. and others},
  title   = {{Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03625-x},
  pmid    = {41287056},
  url     = {https://doi.org/10.1186/s12974-025-03625-x}
}

@article{dijkstra2025-40051009,
  author  = {Dijkstra, Janna I R and Vermunt, Lisa and Venkatraghavan, Vikram and Ozhegov, Georgii and Coomans, Emma M and Ossenkoppele, Rik and van de Giessen, Elsmarieke and Hulsman, Marc and others},
  title   = {{TREM2 risk variants and associated endophenotypes in alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01700-2},
  pmid    = {40051009},
  url     = {https://doi.org/10.1186/s13195-025-01700-2}
}

@article{deczkowska2018-29775591,
  author  = {Deczkowska, A. and Keren-Shaul, H. and Weiner, A. and Colonna, M. and Schwartz, M. and Amit, I.},
  title   = {{Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration}},
  journal = {Cell},
  year    = {2018},
  doi     = {10.1016/j.cell.2018.05.003},
  pmid    = {29775591},
  url     = {https://doi.org/10.1016/j.cell.2018.05.003}
}

@article{xiong2019-31398325,
  author  = {Xiong, X. and Kuang, H. and Ansari, S. and Liu, T. and Gong, J. and Wang, S. and Zhao, X. Y. and Ji, Y. and others},
  title   = {{Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis}},
  journal = {Molecular cell},
  year    = {2019},
  doi     = {10.1016/j.molcel.2019.07.028},
  pmid    = {31398325},
  url     = {https://doi.org/10.1016/j.molcel.2019.07.028}
}

@article{molgora2020-32783918,
  author  = {Molgora, M. and Esaulova, E. and Vermi, W. and Hou, J. and Chen, Y. and Luo, J. and Brioschi, S. and Bugatti, M. and others},
  title   = {{TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.07.013},
  pmid    = {32783918},
  url     = {https://doi.org/10.1016/j.cell.2020.07.013}
}

@article{jay2015-25732305,
  author  = {Jay, T. R. and Miller, C. M. and Cheng, P. J. and Graham, L. C. and Bemiller, S. and Broihier, M. L. and Xu, G. and Margevicius, D. and others},
  title   = {{TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models}},
  journal = {The Journal of experimental medicine},
  year    = {2015},
  doi     = {10.1084/jem.20142322},
  pmid    = {25732305},
  url     = {https://doi.org/10.1084/jem.20142322}
}

@article{depuydt2020-32981416,
  author  = {Depuydt, M. A. C. and Prange, K. H. M. and Slenders, L. and Örd, T. and Elbersen, D. and Boltjes, A. and de Jager, S. C. A. and Asselbergs, F. W. and others},
  title   = {{Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics}},
  journal = {Circulation research},
  year    = {2020},
  doi     = {10.1161/circresaha.120.316770},
  pmid    = {32981416},
  url     = {https://doi.org/10.1161/circresaha.120.316770}
}

@article{wang2022-36306735,
  author  = {Wang, S. and Sudan, R. and Peng, V. and Zhou, Y. and Du, S. and Yuede, C. M. and Lei, T. and Hou, J. and others},
  title   = {{TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways}},
  journal = {Cell},
  year    = {2022},
  doi     = {10.1016/j.cell.2022.09.033},
  pmid    = {36306735},
  url     = {https://doi.org/10.1016/j.cell.2022.09.033}
}

@article{scotthewitt2020-32657463,
  author  = {Scott-Hewitt, N. and Perrucci, F. and Morini, R. and Erreni, M. and Mahoney, M. and Witkowska, A. and Carey, A. and Faggiani, E. and others},
  title   = {{Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia}},
  journal = {The EMBO journal},
  year    = {2020},
  doi     = {10.15252/embj.2020105380},
  pmid    = {32657463},
  url     = {https://doi.org/10.15252/embj.2020105380}
}

@article{seidman2020-32362324,
  author  = {Seidman, J. S. and Troutman, T. D. and Sakai, M. and Gola, A. and Spann, N. J. and Bennett, H. and Bruni, C. M. and Ouyang, Z. and others},
  title   = {{Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis}},
  journal = {Immunity},
  year    = {2020},
  doi     = {10.1016/j.immuni.2020.04.001},
  pmid    = {32362324},
  url     = {https://doi.org/10.1016/j.immuni.2020.04.001}
}

@article{silvin2022-35931085,
  author  = {Silvin, A. and Uderhardt, S. and Piot, C. and Da Mesquita, S. and Yang, K. and Geirsdottir, L. and Mulder, K. and Eyal, D. and others},
  title   = {{Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration}},
  journal = {Immunity},
  year    = {2022},
  doi     = {10.1016/j.immuni.2022.07.004},
  pmid    = {35931085},
  url     = {https://doi.org/10.1016/j.immuni.2022.07.004}
}

@article{cignarella2020-32772264,
  author  = {Cignarella, F. and Filipello, F. and Bollman, B. and Cantoni, C. and Locca, A. and Mikesell, R. and Manis, M. and Ibrahim, A. and others},
  title   = {{TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02193-z},
  pmid    = {32772264},
  url     = {https://doi.org/10.1007/s00401-020-02193-z}
}

@article{tagge2018-29360998,
  author  = {Tagge, C. A. and Fisher, A. M. and Minaeva, O. V. and Gaudreau-Balderrama, A. and Moncaster, J. A. and Zhang, X. L. and Wojnarowicz, M. W. and Casey, N. and others},
  title   = {{Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awx350},
  pmid    = {29360998},
  url     = {https://doi.org/10.1093/brain/awx350}
}

@article{baligacs2024-39639016,
  author  = {Baligács, N. and Albertini, G. and Borrie, S. C. and Serneels, L. and Pridans, C. and Balusu, S. and De Strooper, B.},
  title   = {{Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer's Disease}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-54779-w},
  pmid    = {39639016},
  url     = {https://doi.org/10.1038/s41467-024-54779-w}
}

@article{zhang2020-32000403,
  author  = {Zhang, B. and Li, R. and Zhang, Y. and Gao, X.},
  title   = {{Differential role of triggering receptors expressed on myeloid cells 2 R47H in 3 neurodegenerative diseases based on a systematic review and meta-analysis}},
  journal = {Medicine},
  year    = {2020},
  doi     = {10.1097/md.0000000000018921},
  pmid    = {32000403},
  url     = {https://doi.org/10.1097/md.0000000000018921}
}

@article{karch2015-24951455,
  author  = {Karch, C. M. and Goate, A. M.},
  title   = {{Alzheimer's disease risk genes and mechanisms of disease pathogenesis}},
  journal = {Biological psychiatry},
  year    = {2015},
  doi     = {10.1016/j.biopsych.2014.05.006},
  pmid    = {24951455},
  url     = {https://doi.org/10.1016/j.biopsych.2014.05.006}
}

@article{zhao2018-29518356,
  author  = {Zhao, Y. and Wu, X. and Li, X. and Jiang, L. L. and Gui, X. and Liu, Y. and Sun, Y. and Zhu, B. and others},
  title   = {{TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.01.031},
  pmid    = {29518356},
  url     = {https://doi.org/10.1016/j.neuron.2018.01.031}
}

@article{yuan2016-27196974,
  author  = {Yuan, P. and Condello, C. and Keene, C. D. and Wang, Y. and Bird, T. D. and Paul, S. M. and Luo, W. and Colonna, M. and others},
  title   = {{TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy}},
  journal = {Neuron},
  year    = {2016},
  doi     = {10.1016/j.neuron.2016.05.003},
  pmid    = {27196974},
  url     = {https://doi.org/10.1016/j.neuron.2016.05.003}
}

@article{filipello2018-29752066,
  author  = {Filipello, F. and Morini, R. and Corradini, I. and Zerbi, V. and Canzi, A. and Michalski, B. and Erreni, M. and Markicevic, M. and others},
  title   = {{The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity}},
  journal = {Immunity},
  year    = {2018},
  doi     = {10.1016/j.immuni.2018.04.016},
  pmid    = {29752066},
  url     = {https://doi.org/10.1016/j.immuni.2018.04.016}
}

@article{zhong2019-30911003,
  author  = {Zhong, L. and Xu, Y. and Zhuo, R. and Wang, T. and Wang, K. and Huang, R. and Wang, D. and Gao, Y. and others},
  title   = {{Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model}},
  journal = {Nature communications},
  year    = {2019},
  doi     = {10.1038/s41467-019-09118-9},
  pmid    = {30911003},
  url     = {https://doi.org/10.1038/s41467-019-09118-9}
}

@article{dejanovic2022-37118504,
  author  = {Dejanovic, B. and Wu, T. and Tsai, M. C. and Graykowski, D. and Gandham, V. D. and Rose, C. M. and Bakalarski, C. E. and Ngu, H. and others},
  title   = {{Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models}},
  journal = {Nature aging},
  year    = {2022},
  doi     = {10.1038/s43587-022-00281-1},
  pmid    = {37118504},
  url     = {https://doi.org/10.1038/s43587-022-00281-1}
}

@article{xiang2021-34644146,
  author  = {Xiang, X. and Wind, K. and Wiedemann, T. and Blume, T. and Shi, Y. and Briel, N. and Beyer, L. and Biechele, G. and others},
  title   = {{Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases}},
  journal = {Science translational medicine},
  year    = {2021},
  doi     = {10.1126/scitranslmed.abe5640},
  pmid    = {34644146},
  url     = {https://doi.org/10.1126/scitranslmed.abe5640}
}

@article{scheiblich2024-39059388,
  author  = {Scheiblich, H. and Eikens, F. and Wischhof, L. and Opitz, S. and Jüngling, K. and Cserép, C. and Schmidt, S. V. and Lambertz, J. and others},
  title   = {{Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes}},
  journal = {Neuron},
  year    = {2024},
  doi     = {10.1016/j.neuron.2024.06.029},
  pmid    = {39059388},
  url     = {https://doi.org/10.1016/j.neuron.2024.06.029}
}

@article{borroni2014-24139279,
  author  = {Borroni, B. and Ferrari, F. and Galimberti, D. and Nacmias, B. and Barone, C. and Bagnoli, S. and Fenoglio, C. and Piaceri, I. and others},
  title   = {{Heterozygous TREM2 mutations in frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.09.017},
  pmid    = {24139279},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.09.017}
}

@article{lupton2016-26973105,
  author  = {Lupton, M. K. and Strike, L. and Hansell, N. K. and Wen, W. and Mather, K. A. and Armstrong, N. J. and Thalamuthu, A. and McMahon, K. L. and others},
  title   = {{The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2015.12.023},
  pmid    = {26973105},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.12.023}
}

@article{smith2016-27522519,
  author  = {Smith, A. R. and Smith, R. G. and Condliffe, D. and Hannon, E. and Schalkwyk, L. and Mill, J. and Lunnon, K.},
  title   = {{Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.07.008},
  pmid    = {27522519},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.07.008}
}

@article{li2021-34589742,
  author  = {Li, Q. S. and De Muynck, L.},
  title   = {{Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1}},
  journal = {Brain, behavior, \& immunity - health},
  year    = {2021},
  doi     = {10.1016/j.bbih.2021.100227},
  pmid    = {34589742},
  url     = {https://doi.org/10.1016/j.bbih.2021.100227}
}

@article{biel2023-36620941,
  author  = {Biel, D. and Suárez-Calvet, M. and Hager, P. and Rubinski, A. and Dewenter, A. and Steward, A. and Roemer, S. and Ewers, M. and others},
  title   = {{sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease}},
  journal = {EMBO molecular medicine},
  year    = {2023},
  doi     = {10.15252/emmm.202216987},
  pmid    = {36620941},
  url     = {https://doi.org/10.15252/emmm.202216987}
}

@article{woollacott2018-30111356,
  author  = {Woollacott, I. O. C. and Nicholas, J. M. and Heslegrave, A. and Heller, C. and Foiani, M. S. and Dick, K. M. and Russell, L. L. and Paterson, R. W. and others},
  title   = {{Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0405-8},
  pmid    = {30111356},
  url     = {https://doi.org/10.1186/s13195-018-0405-8}
}

@article{wang2024-38841103,
  author  = {Wang, R. and Zhan, Y. and Zhu, W. and Yang, Q. and Pei, J.},
  title   = {{Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2024},
  doi     = {10.3389/fnagi.2024.1407980},
  pmid    = {38841103},
  url     = {https://doi.org/10.3389/fnagi.2024.1407980}
}

@article{nguyen2020-32840654,
  author  = {Nguyen, A. T. and Wang, K. and Hu, G. and Wang, X. and Miao, Z. and Azevedo, J. A. and Suh, E. and Van Deerlin, V. M. and others},
  title   = {{APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02200-3},
  pmid    = {32840654},
  url     = {https://doi.org/10.1007/s00401-020-02200-3}
}

@article{leyns2017-29073081,
  author  = {Leyns, C. E. G. and Ulrich, J. D. and Finn, M. B. and Stewart, F. R. and Koscal, L. J. and Remolina Serrano, J. and Robinson, G. O. and Anderson, E. and others},
  title   = {{TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2017},
  doi     = {10.1073/pnas.1710311114},
  pmid    = {29073081},
  url     = {https://doi.org/10.1073/pnas.1710311114}
}

@article{safaiyan2021-33606969,
  author  = {Safaiyan, S. and Besson-Girard, S. and Kaya, T. and Cantuti-Castelvetri, L. and Liu, L. and Ji, H. and Schifferer, M. and Gouna, G. and others},
  title   = {{White matter aging drives microglial diversity}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2021.01.027},
  pmid    = {33606969},
  url     = {https://doi.org/10.1016/j.neuron.2021.01.027}
}

@article{daemen2021-33440159,
  author  = {Daemen, S. and Gainullina, A. and Kalugotla, G. and He, L. and Chan, M. M. and Beals, J. W. and Liss, K. H. and Klein, S. and others},
  title   = {{Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2020.108626},
  pmid    = {33440159},
  url     = {https://doi.org/10.1016/j.celrep.2020.108626}
}

@article{griciuc2019-31301936,
  author  = {Griciuc, A. and Patel, S. and Federico, A. N. and Choi, S. H. and Innes, B. J. and Oram, M. K. and Cereghetti, G. and McGinty, D. and others},
  title   = {{TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2019},
  doi     = {10.1016/j.neuron.2019.06.010},
  pmid    = {31301936},
  url     = {https://doi.org/10.1016/j.neuron.2019.06.010}
}

@article{mcquade2020-33097708,
  author  = {McQuade, A. and Kang, Y. J. and Hasselmann, J. and Jairaman, A. and Sotelo, A. and Coburn, M. and Shabestari, S. K. and Chadarevian, J. P. and others},
  title   = {{Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-19227-5},
  pmid    = {33097708},
  url     = {https://doi.org/10.1038/s41467-020-19227-5}
}

@article{bozaserrano2019-31006066,
  author  = {Boza-Serrano, A. and Ruiz, R. and Sanchez-Varo, R. and García-Revilla, J. and Yang, Y. and Jimenez-Ferrer, I. and Paulus, A. and Wennström, M. and others},
  title   = {{Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02013-z},
  pmid    = {31006066},
  url     = {https://doi.org/10.1007/s00401-019-02013-z}
}

@article{song2018-29321225,
  author  = {Song, W. M. and Joshita, S. and Zhou, Y. and Ulland, T. K. and Gilfillan, S. and Colonna, M.},
  title   = {{Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism}},
  journal = {The Journal of experimental medicine},
  year    = {2018},
  doi     = {10.1084/jem.20171529},
  pmid    = {29321225},
  url     = {https://doi.org/10.1084/jem.20171529}
}

@article{hou2021-33586673,
  author  = {Hou, J. and Zhang, J. and Cui, P. and Zhou, Y. and Liu, C. and Wu, X. and Ji, Y. and Wang, S. and others},
  title   = {{TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis}},
  journal = {The Journal of clinical investigation},
  year    = {2021},
  doi     = {10.1172/jci135197},
  pmid    = {33586673},
  url     = {https://doi.org/10.1172/jci135197}
}

@article{govaere2023-37037945,
  author  = {Govaere, O. and Hasoon, M. and Alexander, L. and Cockell, S. and Tiniakos, D. and Ekstedt, M. and Schattenberg, J. M. and Boursier, J. and others},
  title   = {{A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures}},
  journal = {Nature metabolism},
  year    = {2023},
  doi     = {10.1038/s42255-023-00775-1},
  pmid    = {37037945},
  url     = {https://doi.org/10.1038/s42255-023-00775-1}
}

@article{slattery2014-25160042,
  author  = {Slattery, C. F. and Beck, J. A. and Harper, L. and Adamson, G. and Abdi, Z. and Uphill, J. and Campbell, T. and Druyeh, R. and others},
  title   = {{R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2014},
  doi     = {10.1016/j.jalz.2014.05.1751},
  pmid    = {25160042},
  url     = {https://doi.org/10.1016/j.jalz.2014.05.1751}
}

@article{indirachandran2023-35712786,
  author  = {Indira Chandran, V. and Wernberg, C. W. and Lauridsen, M. M. and Skytthe, M. K. and Bendixen, S. M. and Larsen, F. T. and Hansen, C. D. and Grønkjær, L. L. and others},
  title   = {{Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness}},
  journal = {Hepatology (Baltimore, Md.)},
  year    = {2023},
  doi     = {10.1002/hep.32620},
  pmid    = {35712786},
  url     = {https://doi.org/10.1002/hep.32620}
}

@article{niculescu2020-31792364,
  author  = {Niculescu, A. B. and Le-Niculescu, H. and Roseberry, K. and Wang, S. and Hart, J. and Kaur, A. and Robertson, H. and Jones, T. and others},
  title   = {{Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs}},
  journal = {Molecular psychiatry},
  year    = {2020},
  doi     = {10.1038/s41380-019-0602-2},
  pmid    = {31792364},
  url     = {https://doi.org/10.1038/s41380-019-0602-2}
}

@article{kunkle2017-28738127,
  author  = {Kunkle, B. W. and Vardarajan, B. N. and Naj, A. C. and Whitehead, P. L. and Rolati, S. and Slifer, S. and Carney, R. M. and Cuccaro, M. L. and others},
  title   = {{Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.1518},
  pmid    = {28738127},
  url     = {https://doi.org/10.1001/jamaneurol.2017.1518}
}

@article{takahashi2005-15728241,
  author  = {Takahashi, K. and Rochford, C. D. and Neumann, H.},
  title   = {{Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2}},
  journal = {The Journal of experimental medicine},
  year    = {2005},
  doi     = {10.1084/jem.20041611},
  pmid    = {15728241},
  url     = {https://doi.org/10.1084/jem.20041611}
}

@article{cochain2018-29545365,
  author  = {Cochain, C. and Vafadarnejad, E. and Arampatzi, P. and Pelisek, J. and Winkels, H. and Ley, K. and Wolf, D. and Saliba, A. E. and others},
  title   = {{Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis}},
  journal = {Circulation research},
  year    = {2018},
  doi     = {10.1161/circresaha.117.312509},
  pmid    = {29545365},
  url     = {https://doi.org/10.1161/circresaha.117.312509}
}

@article{yeh2016-27477018,
  author  = {Yeh, F. L. and Wang, Y. and Tom, I. and Gonzalez, L. C. and Sheng, M.},
  title   = {{TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia}},
  journal = {Neuron},
  year    = {2016},
  doi     = {10.1016/j.neuron.2016.06.015},
  pmid    = {27477018},
  url     = {https://doi.org/10.1016/j.neuron.2016.06.015}
}

@article{deczkowska2020-32531244,
  author  = {Deczkowska, A. and Weiner, A. and Amit, I.},
  title   = {{The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.05.003},
  pmid    = {32531244},
  url     = {https://doi.org/10.1016/j.cell.2020.05.003}
}

@article{jay2017-28100745,
  author  = {Jay, T. R. and Hirsch, A. M. and Broihier, M. L. and Miller, C. M. and Neilson, L. E. and Ransohoff, R. M. and Lamb, B. T. and Landreth, G. E.},
  title   = {{Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2110-16.2016},
  pmid    = {28100745},
  url     = {https://doi.org/10.1523/jneurosci.2110-16.2016}
}

@article{vanlengerich2023-36635496,
  author  = {van Lengerich, B. and Zhan, L. and Xia, D. and Chan, D. and Joy, D. and Park, J. I. and Tatarakis, D. and Calvert, M. and others},
  title   = {{A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models}},
  journal = {Nature neuroscience},
  year    = {2023},
  doi     = {10.1038/s41593-022-01240-0},
  pmid    = {36635496},
  url     = {https://doi.org/10.1038/s41593-022-01240-0}
}

@article{park2023-37081148,
  author  = {Park, M. D. and Reyes-Torres, I. and LeBerichel, J. and Hamon, P. and LaMarche, N. M. and Hegde, S. and Belabed, M. and Troncoso, L. and others},
  title   = {{TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-023-01475-4},
  pmid    = {37081148},
  url     = {https://doi.org/10.1038/s41590-023-01475-4}
}

@article{song2017-27520774,
  author  = {Song, W. and Hooli, B. and Mullin, K. and Jin, S. C. and Cella, M. and Ulland, T. K. and Wang, Y. and Tanzi, R. E. and others},
  title   = {{Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.07.004},
  pmid    = {27520774},
  url     = {https://doi.org/10.1016/j.jalz.2016.07.004}
}

@article{gratuze2020-32544086,
  author  = {Gratuze, M. and Leyns, C. E. and Sauerbeck, A. D. and St-Pierre, M. K. and Xiong, M. and Kim, N. and Serrano, JR. and MÈ, Tremblay and others},
  title   = {{Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration}},
  journal = {The Journal of clinical investigation},
  year    = {2020},
  doi     = {10.1172/jci138179},
  pmid    = {32544086},
  url     = {https://doi.org/10.1172/jci138179}
}

@article{gratuze2021-34100905,
  author  = {Gratuze, M. and Chen, Y. and Parhizkar, S. and Jain, N. and Strickland, M. R. and Serrano, JR. and Colonna, M. and Ulrich, J. D. and others},
  title   = {{Activated microglia mitigate Aβ-associated tau seeding and spreading}},
  journal = {The Journal of experimental medicine},
  year    = {2021},
  doi     = {10.1084/jem.20210542},
  pmid    = {34100905},
  url     = {https://doi.org/10.1084/jem.20210542}
}

@article{kirschenbaum2024-38134933,
  author  = {Kirschenbaum, D. and Xie, K. and Ingelfinger, F. and Katzenelenbogen, Y. and Abadie, K. and Look, T. and Sheban, F. and Phan, T. S. and others},
  title   = {{Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma}},
  journal = {Cell},
  year    = {2024},
  doi     = {10.1016/j.cell.2023.11.032},
  pmid    = {38134933},
  url     = {https://doi.org/10.1016/j.cell.2023.11.032}
}

@article{ma2018-30239611,
  author  = {MÁ, Araque Caballero and Suárez-Calvet, M. and Duering, M. and Franzmeier, N. and Benzinger, T. and Fagan, A. M. and Bateman, R. J. and Jack, C. R. and others},
  title   = {{White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awy229},
  pmid    = {30239611},
  url     = {https://doi.org/10.1093/brain/awy229}
}

@article{xie2022-34916658,
  author  = {Xie, M. and Liu, Y. U. and Zhao, S. and Zhang, L. and Bosco, D. B. and Pang, Y. P. and Zhong, J. and Sheth, U. and others},
  title   = {{TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration}},
  journal = {Nature neuroscience},
  year    = {2022},
  doi     = {10.1038/s41593-021-00975-6},
  pmid    = {34916658},
  url     = {https://doi.org/10.1038/s41593-021-00975-6}
}

@article{croizer2024-38561380,
  author  = {Croizer, H. and Mhaidly, R. and Kieffer, Y. and Gentric, G. and Djerroudi, L. and Leclere, R. and Pelon, F. and Robley, C. and others},
  title   = {{Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-47068-z},
  pmid    = {38561380},
  url     = {https://doi.org/10.1038/s41467-024-47068-z}
}

@article{jain2023-36219197,
  author  = {Jain, N. and Lewis, C. A. and Ulrich, J. D. and Holtzman, D. M.},
  title   = {{Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading}},
  journal = {The Journal of experimental medicine},
  year    = {2023},
  doi     = {10.1084/jem.20220654},
  pmid    = {36219197},
  url     = {https://doi.org/10.1084/jem.20220654}
}

@article{ruedacarrasco2023-37575021,
  author  = {Rueda-Carrasco, J. and Sokolova, D. and Lee, S. E. and Childs, T. and Jurčáková, N. and Crowley, G. and De Schepper, S. and Ge, J. Z. and others},
  title   = {{Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models}},
  journal = {The EMBO journal},
  year    = {2023},
  doi     = {10.15252/embj.2022113246},
  pmid    = {37575021},
  url     = {https://doi.org/10.15252/embj.2022113246}
}

@article{bashore2024-38385291,
  author  = {Bashore, A. C. and Yan, H. and Xue, C. and Zhu, L. Y. and Kim, E. and Mawson, T. and Coronel, J. and Chung, A. and others},
  title   = {{High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2024},
  doi     = {10.1161/atvbaha.123.320524},
  pmid    = {38385291},
  url     = {https://doi.org/10.1161/atvbaha.123.320524}
}

@article{brosseron2018-29482610,
  author  = {Brosseron, F. and Traschütz, A. and Widmann, C. N. and Kummer, M. P. and Tacik, P. and Santarelli, F. and Jessen, F. and Heneka, M. T.},
  title   = {{Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0353-3},
  pmid    = {29482610},
  url     = {https://doi.org/10.1186/s13195-018-0353-3}
}

@article{patel2019-30924900,
  author  = {Patel, D. and Mez, J. and Vardarajan, B. N. and Staley, L. and Chung, J. and Zhang, X. and Farrell, J. J. and Rynkiewicz, M. J. and others},
  title   = {{Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry}},
  journal = {JAMA network open},
  year    = {2019},
  doi     = {10.1001/jamanetworkopen.2019.1350},
  pmid    = {30924900},
  url     = {https://doi.org/10.1001/jamanetworkopen.2019.1350}
}

@article{huang2015-25852195,
  author  = {Huang, M. and Wang, D. and Xu, Z. and Xu, Y. and Xu, X. and Ma, Y. and Xia, Z.},
  title   = {{Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2015},
  doi     = {10.1177/1533317515577128},
  pmid    = {25852195},
  url     = {https://doi.org/10.1177/1533317515577128}
}

@article{vanhulle2021-33336877,
  author  = {Van Hulle, C. and Jonaitis, E. M. and Betthauser, T. J. and Batrla, R. and Wild, N. and Kollmorgen, G. and Andreasson, U. and Okonkwo, O. and others},
  title   = {{An examination of a novel multipanel of CSF biomarkers in the Alzheimer's disease clinical and pathological continuum}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12204},
  pmid    = {33336877},
  url     = {https://doi.org/10.1002/alz.12204}
}

@article{efthymiou2017-28549481,
  author  = {Efthymiou, A. G. and Goate, A. M.},
  title   = {{Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0184-x},
  pmid    = {28549481},
  url     = {https://doi.org/10.1186/s13024-017-0184-x}
}

@article{gratuze2018-30572908,
  author  = {Gratuze, M. and Leyns, C. E. G. and Holtzman, D. M.},
  title   = {{New insights into the role of TREM2 in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0298-9},
  pmid    = {30572908},
  url     = {https://doi.org/10.1186/s13024-018-0298-9}
}

@article{lucin2013-24012002,
  author  = {Lucin, K. M. and O'Brien, C. E. and Bieri, G. and Czirr, E. and Mosher, K. I. and Abbey, R. J. and Mastroeni, D. F. and Rogers, J. and others},
  title   = {{Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease}},
  journal = {Neuron},
  year    = {2013},
  doi     = {10.1016/j.neuron.2013.06.046},
  pmid    = {24012002},
  url     = {https://doi.org/10.1016/j.neuron.2013.06.046}
}

@article{zhong2017-28209725,
  author  = {Zhong, L. and Chen, X. F. and Wang, T. and Wang, Z. and Liao, C. and Huang, R. and Wang, D. and others},
  title   = {{Soluble TREM2 induces inflammatory responses and enhances microglial survival}},
  journal = {The Journal of experimental medicine},
  year    = {2017},
  doi     = {10.1084/jem.20160844},
  pmid    = {28209725},
  url     = {https://doi.org/10.1084/jem.20160844}
}

@article{hammond2019-30995509,
  author  = {Hammond, T. R. and Marsh, S. E. and Stevens, B.},
  title   = {{Immune Signaling in Neurodegeneration}},
  journal = {Immunity},
  year    = {2019},
  doi     = {10.1016/j.immuni.2019.03.016},
  pmid    = {30995509},
  url     = {https://doi.org/10.1016/j.immuni.2019.03.016}
}

@article{ulrich2017-28426958,
  author  = {Ulrich, J. D. and Ulland, T. K. and Colonna, M. and Holtzman, D. M.},
  title   = {{Elucidating the Role of TREM2 in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.02.042},
  pmid    = {28426958},
  url     = {https://doi.org/10.1016/j.neuron.2017.02.042}
}

@article{schlepckow2020-32154671,
  author  = {Schlepckow, K. and Monroe, K. M. and Kleinberger, G. and Cantuti-Castelvetri, L. and Parhizkar, S. and Xia, D. and Willem, M. and Werner, G. and others},
  title   = {{Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region}},
  journal = {EMBO molecular medicine},
  year    = {2020},
  doi     = {10.15252/emmm.201911227},
  pmid    = {32154671},
  url     = {https://doi.org/10.15252/emmm.201911227}
}

@article{jung2022-35933399,
  author  = {Jung, S. H. and Hwang, B. H. and Shin, S. and Park, E. H. and Park, S. H. and Kim, C. W. and Kim, E. and Choo, E. and others},
  title   = {{Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts}},
  journal = {Nature communications},
  year    = {2022},
  doi     = {10.1038/s41467-022-32284-2},
  pmid    = {35933399},
  url     = {https://doi.org/10.1038/s41467-022-32284-2}
}

@article{griciuc2021-33560670,
  author  = {Griciuc, A. and Tanzi, R. E.},
  title   = {{The role of innate immune genes in Alzheimer's disease}},
  journal = {Current opinion in neurology},
  year    = {2021},
  doi     = {10.1097/wco.0000000000000911},
  pmid    = {33560670},
  url     = {https://doi.org/10.1097/wco.0000000000000911}
}

@article{gouna2021-34424266,
  author  = {Gouna, G. and Klose, C. and Bosch-Queralt, M. and Liu, L. and Gokce, O. and Schifferer, M. and Cantuti-Castelvetri, L. and Simons, M.},
  title   = {{TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination}},
  journal = {The Journal of experimental medicine},
  year    = {2021},
  doi     = {10.1084/jem.20210227},
  pmid    = {34424266},
  url     = {https://doi.org/10.1084/jem.20210227}
}

@article{rachmian2024-38637622,
  author  = {Rachmian, N. and Medina, S. and Cherqui, U. and Akiva, H. and Deitch, D. and Edilbi, D. and Croese, T. and Salame, T. M. and others},
  title   = {{Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain}},
  journal = {Nature neuroscience},
  year    = {2024},
  doi     = {10.1038/s41593-024-01620-8},
  pmid    = {38637622},
  url     = {https://doi.org/10.1038/s41593-024-01620-8}
}

@article{dong2021-33603230,
  author  = {Dong, Y. and D'Mello, C. and Pinsky, W. and Lozinski, B. M. and Kaushik, D. K. and Ghorbani, S. and Moezzi, D. and Brown, D. and others},
  title   = {{Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia}},
  journal = {Nature neuroscience},
  year    = {2021},
  doi     = {10.1038/s41593-021-00801-z},
  pmid    = {33603230},
  url     = {https://doi.org/10.1038/s41593-021-00801-z}
}

@article{henjum2016-27121148,
  author  = {Henjum, K. and Almdahl, I. S. and Årskog, V. and Minthon, L. and Hansson, O. and Fladby, T. and Nilsson, L. N.},
  title   = {{Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2016},
  doi     = {10.1186/s13195-016-0182-1},
  pmid    = {27121148},
  url     = {https://doi.org/10.1186/s13195-016-0182-1}
}

@article{ganguly2024-39172787,
  author  = {Ganguly, S. and Rosenthal, S. B. and Ishizuka, K. and Troutman, T. D. and Rohm, T. V. and Khader, N. and Aleman-Muench, G. and Sano, Y. and others},
  title   = {{Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2024},
  doi     = {10.1073/pnas.2405746121},
  pmid    = {39172787},
  url     = {https://doi.org/10.1073/pnas.2405746121}
}

@article{schlepckow2023-37863592,
  author  = {Schlepckow, K. and Morenas-Rodríguez, E. and Hong, S. and Haass, C.},
  title   = {{Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease}},
  journal = {The Lancet. Neurology},
  year    = {2023},
  doi     = {10.1016/s1474-4422(23)00247-8},
  pmid    = {37863592},
  url     = {https://doi.org/10.1016/s1474-4422(23)00247-8}
}

@article{tagliatti2024-38159572,
  author  = {Tagliatti, E. and Desiato, G. and Mancinelli, S. and Bizzotto, M. and Gagliani, M. C. and Faggiani, E. and Hernández-Soto, R. and Cugurra, A. and others},
  title   = {{Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development}},
  journal = {Immunity},
  year    = {2024},
  doi     = {10.1016/j.immuni.2023.12.002},
  pmid    = {38159572},
  url     = {https://doi.org/10.1016/j.immuni.2023.12.002}
}

@article{cui2025-39971937,
  author  = {Cui, H. and Banerjee, S. and Xie, N. and Hussain, M. and Jaiswal, A. and Liu, H. and Kulkarni, T. and Antony, V. B. and others},
  title   = {{TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-57024-0},
  pmid    = {39971937},
  url     = {https://doi.org/10.1038/s41467-025-57024-0}
}

@article{wang2018-30558641,
  author  = {Wang, H. and Li, Y. and Ryder, J. W. and Hole, J. T. and Ebert, P. J. and Airey, D. C. and Qian, H. R. and Logsdon, B. and others},
  title   = {{Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0296-y},
  pmid    = {30558641},
  url     = {https://doi.org/10.1186/s13024-018-0296-y}
}

@article{delaguila2018-29480181,
  author  = {Del-Aguila, J. L. and Fernández, M. V. and Schindler, S. and Ibanez, L. and Deming, Y. and Ma, S. and Saef, B. and Black, K. and others},
  title   = {{Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-170834},
  pmid    = {29480181},
  url     = {https://doi.org/10.3233/jad-170834}
}

@article{preuss2020-33172468,
  author  = {Preuss, C. and Pandey, R. and Piazza, E. and Fine, A. and Uyar, A. and Perumal, T. and Garceau, D. and Kotredes, K. P. and others},
  title   = {{A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00412-5},
  pmid    = {33172468},
  url     = {https://doi.org/10.1186/s13024-020-00412-5}
}

@article{sanghvi2020-31898332,
  author  = {Sanghvi, H. and Singh, R. and Morrin, H. and Rajkumar, A. P.},
  title   = {{Systematic review of genetic association studies in people with Lewy body dementia}},
  journal = {International journal of geriatric psychiatry},
  year    = {2020},
  doi     = {10.1002/gps.5260},
  pmid    = {31898332},
  url     = {https://doi.org/10.1002/gps.5260}
}

@article{ebbert2016-26449541,
  author  = {Ebbert, M. T. W. and Boehme, K. L. and Wadsworth, M. E. and Staley, L. A. and {Alzheimer's Disease Neuroimaging Initiative} and {Alzheimer's Disease Genetics Consortium} and Mukherjee, S. and Crane, P. K. and others},
  title   = {{Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2015.08.163},
  pmid    = {26449541},
  url     = {https://doi.org/10.1016/j.jalz.2015.08.163}
}

@article{feng2014-24602511,
  author  = {Feng, Shu-jun and Nie, Kun and Gan, Rong and Huang, Jing and Zhang, You-wen and Wang, Li-min and Zhao, Jie-hao and Tang, Hong-mei and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.01.142},
  pmid    = {24602511},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.01.142}
}

@article{tiwari2019-31410002,
  author  = {Tiwari, S. and Atluri, V. and Kaushik, A. and Yndart, A. and Nair, M.},
  title   = {{Alzheimer's disease: pathogenesis, diagnostics, and therapeutics}},
  journal = {International journal of nanomedicine},
  year    = {2019},
  doi     = {10.2147/ijn.s200490},
  pmid    = {31410002},
  url     = {https://doi.org/10.2147/ijn.s200490}
}

@article{nugent2020-31902528,
  author  = {Nugent, A. A. and Lin, K. and van Lengerich, B. and Lianoglou, S. and Przybyla, L. and Davis, S. S. and Llapashtica, C. and Wang, J. and others},
  title   = {{TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2019.12.007},
  pmid    = {31902528},
  url     = {https://doi.org/10.1016/j.neuron.2019.12.007}
}

@article{paloneva2002-12080485,
  author  = {Paloneva, J. and Manninen, T. and Christman, G. and Hovanes, K. and Mandelin, J. and Adolfsson, R. and Bianchin, M. and Bird, T. and others},
  title   = {{Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype}},
  journal = {American journal of human genetics},
  year    = {2002},
  doi     = {10.1086/342259},
  pmid    = {12080485},
  url     = {https://doi.org/10.1086/342259}
}

@article{katzenelenbogen2020-32783915,
  author  = {Katzenelenbogen, Y. and Sheban, F. and Yalin, A. and Yofe, I. and Svetlichnyy, D. and Jaitin, D. A. and Bornstein, C. and Moshe, A. and others},
  title   = {{Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.06.032},
  pmid    = {32783915},
  url     = {https://doi.org/10.1016/j.cell.2020.06.032}
}

@article{poliani2015-25893602,
  author  = {Poliani, P. L. and Wang, Y. and Fontana, E. and Robinette, M. L. and Yamanishi, Y. and Gilfillan, S. and Colonna, M.},
  title   = {{TREM2 sustains microglial expansion during aging and response to demyelination}},
  journal = {The Journal of clinical investigation},
  year    = {2015},
  doi     = {10.1172/jci77983},
  pmid    = {25893602},
  url     = {https://doi.org/10.1172/jci77983}
}

@article{jay2017-28768545,
  author  = {Jay, T. R. and von Saucken, V. E. and Landreth, G. E.},
  title   = {{TREM2 in Neurodegenerative Diseases}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0197-5},
  pmid    = {28768545},
  url     = {https://doi.org/10.1186/s13024-017-0197-5}
}

@article{bisht2016-26847266,
  author  = {Bisht, K. and Sharma, K. P. and Lecours, C. and Sánchez, M. G. and El Hajj, H. and Milior, G. and Olmos-Alonso, A. and Gómez-Nicola, D. and others},
  title   = {{Dark microglia: A new phenotype predominantly associated with pathological states}},
  journal = {Glia},
  year    = {2016},
  doi     = {10.1002/glia.22966},
  pmid    = {26847266},
  url     = {https://doi.org/10.1002/glia.22966}
}

@article{lee2018-29518357,
  author  = {Lee, C. Y. D. and Daggett, A. and Gu, X. and Jiang, L. L. and Langfelder, P. and Li, X. and Wang, N. and Zhao, Y. and others},
  title   = {{Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.02.002},
  pmid    = {29518357},
  url     = {https://doi.org/10.1016/j.neuron.2018.02.002}
}

@article{chen2020-32466767,
  author  = {Chen, S. and Peng, J. and Sherchan, P. and Ma, Y. and Xiang, S. and Yan, F. and Zhao, H. and Jiang, Y. and others},
  title   = {{TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01853-x},
  pmid    = {32466767},
  url     = {https://doi.org/10.1186/s12974-020-01853-x}
}

@article{fabre2023-37027478,
  author  = {Fabre, T. and Barron, A. M. S. and Christensen, S. M. and Asano, S. and Bound, K. and Lech, M. P. and Wadsworth, M. H. and Chen, X. and others},
  title   = {{Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation}},
  journal = {Science immunology},
  year    = {2023},
  doi     = {10.1126/sciimmunol.add8945},
  pmid    = {37027478},
  url     = {https://doi.org/10.1126/sciimmunol.add8945}
}

@article{cantoni2015-25631124,
  author  = {Cantoni, C. and Bollman, B. and Licastro, D. and Xie, M. and Mikesell, R. and Schmidt, R. and Yuede, C. M. and Galimberti, D. and others},
  title   = {{TREM2 regulates microglial cell activation in response to demyelination in vivo}},
  journal = {Acta neuropathologica},
  year    = {2015},
  doi     = {10.1007/s00401-015-1388-1},
  pmid    = {25631124},
  url     = {https://doi.org/10.1007/s00401-015-1388-1}
}

@article{wang2023-36521495,
  author  = {Wang, X. and He, Q. and Zhou, C. and Xu, Y. and Liu, D. and Fujiwara, N. and Kubota, N. and Click, A. and others},
  title   = {{Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development}},
  journal = {Immunity},
  year    = {2023},
  doi     = {10.1016/j.immuni.2022.11.013},
  pmid    = {36521495},
  url     = {https://doi.org/10.1016/j.immuni.2022.11.013}
}

@article{carmona2018-30033062,
  author  = {Carmona, S. and Zahs, K. and Wu, E. and Dakin, K. and Bras, J. and Guerreiro, R.},
  title   = {{The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders}},
  journal = {The Lancet. Neurology},
  year    = {2018},
  doi     = {10.1016/s1474-4422(18)30232-1},
  pmid    = {30033062},
  url     = {https://doi.org/10.1016/s1474-4422(18)30232-1}
}

@article{chenghathaway2018-29859094,
  author  = {Cheng-Hathaway, P. J. and Reed-Geaghan, E. G. and Jay, T. R. and Casali, B. T. and Bemiller, S. M. and Puntambekar, S. S. and von Saucken, V. E. and Williams, R. Y. and others},
  title   = {{The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0262-8},
  pmid    = {29859094},
  url     = {https://doi.org/10.1186/s13024-018-0262-8}
}

@article{zhao2020-32199103,
  author  = {Zhao, N. and Ren, Y. and Yamazaki, Y. and Qiao, W. and Li, F. and Felton, L. M. and Mahmoudiandehkordi, S. and Kueider-Paisley, A. and others},
  title   = {{Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2020.02.034},
  pmid    = {32199103},
  url     = {https://doi.org/10.1016/j.neuron.2020.02.034}
}

@article{kleinberger2017-28559417,
  author  = {Kleinberger, G. and Brendel, M. and Mracsko, E. and Wefers, B. and Groeneweg, L. and Xiang, X. and Focke, C. and Deußing, M. and others},
  title   = {{The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism}},
  journal = {The EMBO journal},
  year    = {2017},
  doi     = {10.15252/embj.201796516},
  pmid    = {28559417},
  url     = {https://doi.org/10.15252/embj.201796516}
}

@article{ridge2016-27036079,
  author  = {Ridge, P. G. and Hoyt, K. B. and Boehme, K. and Mukherjee, S. and Crane, P. K. and Haines, J. L. and Mayeux, R. and Farrer, L. A. and others},
  title   = {{Assessment of the genetic variance of late-onset Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.02.024},
  pmid    = {27036079},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.02.024}
}

@article{kianishabestari2022-35705056,
  author  = {Kiani Shabestari, S. and Morabito, S. and Danhash, E. P. and McQuade, A. and Sanchez, JR. and Miyoshi, E. and Chadarevian, J. P. and Claes, C. and others},
  title   = {{Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice}},
  journal = {Cell reports},
  year    = {2022},
  doi     = {10.1016/j.celrep.2022.110961},
  pmid    = {35705056},
  url     = {https://doi.org/10.1016/j.celrep.2022.110961}
}

@article{sayed2018-30232263,
  author  = {Sayed, F. A. and Telpoukhovskaia, M. and Kodama, L. and Li, Y. and Zhou, Y. and Le, D. and Hauduc, A. and Ludwig, C. and others},
  title   = {{Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2018},
  doi     = {10.1073/pnas.1811411115},
  pmid    = {30232263},
  url     = {https://doi.org/10.1073/pnas.1811411115}
}

@article{sayed2021-34851693,
  author  = {Sayed, F. A. and Kodama, L. and Fan, L. and Carling, G. K. and Udeochu, J. C. and Le, D. and Li, Q. and Zhou, L. and others},
  title   = {{AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation}},
  journal = {Science translational medicine},
  year    = {2021},
  doi     = {10.1126/scitranslmed.abe3947},
  pmid    = {34851693},
  url     = {https://doi.org/10.1126/scitranslmed.abe3947}
}

@article{pottier2013-23380991,
  author  = {Pottier, C. and Wallon, D. and Rousseau, S. and Rovelet-Lecrux, A. and Richard, A. C. and Rollin-Sillaire, A. and Frebourg, T. and Campion, D. and others},
  title   = {{TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-122311},
  pmid    = {23380991},
  url     = {https://doi.org/10.3233/jad-122311}
}

@article{wong2022-36229464,
  author  = {Wong, H. Y. and Sheng, Q. and Hesterberg, A. B. and Croessmann, S. and Rios, B. L. and Giri, K. and Jackson, J. and Miranda, A. X. and others},
  title   = {{Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease}},
  journal = {Nature communications},
  year    = {2022},
  doi     = {10.1038/s41467-022-33780-1},
  pmid    = {36229464},
  url     = {https://doi.org/10.1038/s41467-022-33780-1}
}

@article{do2022-35867799,
  author  = {Do, T. H. and Ma, F. and Andrade, P. R. and Teles, R. and de Andrade Silva, B. J. and Hu, C. and Espinoza, A. and Hsu, J. E. and others},
  title   = {{TREM2 macrophages induced by human lipids drive inflammation in acne lesions}},
  journal = {Science immunology},
  year    = {2022},
  doi     = {10.1126/sciimmunol.abo2787},
  pmid    = {35867799},
  url     = {https://doi.org/10.1126/sciimmunol.abo2787}
}

@article{gratuze2023-36368315,
  author  = {Gratuze, M. and Schlachetzki, J. C. M. and D'Oliveira Albanus, R. and Jain, N. and Novotny, B. and Brase, L. and Rodriguez, L. and Mansel, C. and others},
  title   = {{TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4}},
  journal = {Neuron},
  year    = {2023},
  doi     = {10.1016/j.neuron.2022.10.022},
  pmid    = {36368315},
  url     = {https://doi.org/10.1016/j.neuron.2022.10.022}
}

@article{beckman2021-33734581,
  author  = {Beckman, D. and Chakrabarty, P. and Ott, S. and Dao, A. and Zhou, E. and Janssen, W. G. and Donis-Cox, K. and Muller, S. and others},
  title   = {{A novel tau-based rhesus monkey model of Alzheimer's pathogenesis}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12318},
  pmid    = {33734581},
  url     = {https://doi.org/10.1002/alz.12318}
}

@article{zhao2022-36107206,
  author  = {Zhao, N. and Qiao, W. and Li, F. and Ren, Y. and Zheng, J. and Martens, Y. A. and Wang, X. and Li, L. and others},
  title   = {{Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia}},
  journal = {The Journal of experimental medicine},
  year    = {2022},
  doi     = {10.1084/jem.20212479},
  pmid    = {36107206},
  url     = {https://doi.org/10.1084/jem.20212479}
}

@article{filipello2023-37115208,
  author  = {Filipello, F. and You, S. F. and Mirfakhar, F. S. and Mahali, S. and Bollman, B. and Acquarone, M. and Korvatska, O. and Marsh, J. A. and others},
  title   = {{Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation}},
  journal = {Acta neuropathologica},
  year    = {2023},
  doi     = {10.1007/s00401-023-02568-y},
  pmid    = {37115208},
  url     = {https://doi.org/10.1007/s00401-023-02568-y}
}

@article{iizasa2021-33863908,
  author  = {Iizasa, E. and Chuma, Y. and Uematsu, T. and Kubota, M. and Kawaguchi, H. and Umemura, M. and Toyonaga, K. and Kiyohara, H. and others},
  title   = {{TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-22620-3},
  pmid    = {33863908},
  url     = {https://doi.org/10.1038/s41467-021-22620-3}
}

@article{rauchmann2019-30458365,
  author  = {Rauchmann, B. S. and Schneider-Axmann, T. and Alexopoulos, P. and Perneczky, R. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum}},
  journal = {Neurobiology of aging},
  year    = {2019},
  doi     = {10.1016/j.neurobiolaging.2018.10.022},
  pmid    = {30458365},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2018.10.022}
}

@article{mocci2024-38639096,
  author  = {Mocci, G. and Sukhavasi, K. and Örd, T. and Bankier, S. and Singha, P. and Arasu, U. T. and Agbabiaje, O. O. and Mäkinen, P. and others},
  title   = {{Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis}},
  journal = {Circulation research},
  year    = {2024},
  doi     = {10.1161/circresaha.123.323184},
  pmid    = {38639096},
  url     = {https://doi.org/10.1161/circresaha.123.323184}
}

@article{turnbull2006-16951310,
  author  = {Turnbull, Isaiah R. and Gilfillan, Susan and Cella, Marina and Aoshi, Taiki and Miller, Mark J. and Piccio, Laura M. and Hernandez, Maristela and Colonna, Marco},
  title   = {{Cutting Edge: TREM-2 Attenuates Macrophage Activation}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.6.3520},
  pmid    = {16951310},
  url     = {https://doi.org/10.4049/jimmunol.177.6.3520}
}

@article{jiang2016-27501831,
  author  = {Jiang, T. and Hou, J. K. and Gao, Q. and Yu, J. T. and Zhou, J. S. and Zhao, H. D. and Zhang, Y. D.},
  title   = {{TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects}},
  journal = {Current neurovascular research},
  year    = {2016},
  doi     = {10.2174/1567202613666160808095530},
  pmid    = {27501831},
  url     = {https://doi.org/10.2174/1567202613666160808095530}
}

@article{hamerman2006-16887962,
  author  = {Hamerman, Jessica A. and Jarjoura, Jessica R and Humphrey, Mary Beth and Nakamura, Mary C. and Seaman, William E. and Lanier, Lewis L.},
  title   = {{Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.4.2051},
  pmid    = {16887962},
  url     = {https://doi.org/10.4049/jimmunol.177.4.2051}
}

@article{piccio2008-18790823,
  author  = {Piccio, Laura M. and Buonsanti, Cecilia and Cella, Marina and Tassi, Ilaria and Schmidt, Robert E. and Fenoglio, Chiara and Rinker, John Robert and Naismith, Robert T. and Panina‐Bordignon, Paola and Passini, Nadia and Galimberti, Daniela and Scarpini, Elio Angelo and Colonna, Marco and Cross, Anne Haney},
  title   = {{Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation}},
  journal = {Brain},
  year    = {2008},
  doi     = {10.1093/brain/awn217},
  pmid    = {18790823},
  url     = {https://doi.org/10.1093/brain/awn217}
}

@article{hsieh2009-19302484,
  author  = {Hsieh, C. L. and Koike, M. and Spusta, S. C. and Niemi, E. C. and Yenari, M. and Nakamura, M. C. and Seaman, W. E.},
  title   = {{A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06042.x},
  pmid    = {19302484},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.06042.x}
}

@article{bouchon2001-11602640,
  author  = {Bouchon, A. and Hernández-Munain, C. and Cella, M. and Colonna, M.},
  title   = {{A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells}},
  journal = {The Journal of experimental medicine},
  year    = {2001},
  doi     = {10.1084/jem.194.8.1111},
  pmid    = {11602640},
  url     = {https://doi.org/10.1084/jem.194.8.1111}
}

@article{takahashi2007-17425404,
  author  = {Takahashi, K. and Prinz, M. and Stagi, M. and Chechneva, O. and Neumann, H.},
  title   = {{TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis}},
  journal = {PLoS medicine},
  year    = {2007},
  doi     = {10.1371/journal.pmed.0040124},
  pmid    = {17425404},
  url     = {https://doi.org/10.1371/journal.pmed.0040124}
}

@article{kawabori2015-25716838,
  author  = {Kawabori, M. and Kacimi, R. and Kauppinen, T. and Calosing, C. and Kim, J. Y. and Hsieh, C. L. and Nakamura, M. C. and Yenari, M. A.},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.2620-14.2015},
  pmid    = {25716838},
  url     = {https://doi.org/10.1523/jneurosci.2620-14.2015}
}

@article{binnewies2021-34686340,
  author  = {Binnewies, M. and Pollack, J. L. and Rudolph, J. and Dash, S. and Abushawish, M. and Lee, T. and Jahchan, N. S. and Canaday, P. and others},
  title   = {{Targeting TREM2 on tumor-associated macrophages enhances immunotherapy}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.109844},
  pmid    = {34686340},
  url     = {https://doi.org/10.1016/j.celrep.2021.109844}
}

@article{zheng2017-28077724,
  author  = {Zheng, H. and Jia, L. and Liu, C. C. and Rong, Z. and Zhong, L. and Yang, L. and Chen, X. F. and Fryer, J. D. and others},
  title   = {{TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2459-16.2017},
  pmid    = {28077724},
  url     = {https://doi.org/10.1523/jneurosci.2459-16.2017}
}

@article{ulrich2014-24893973,
  author  = {Ulrich, J. D. and Finn, M. B. and Wang, Y. and Shen, A. and Mahan, T. E. and Jiang, H. and Stewart, F. R. and Piccio, L. and others},
  title   = {{Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2014},
  doi     = {10.1186/1750-1326-9-20},
  pmid    = {24893973},
  url     = {https://doi.org/10.1186/1750-1326-9-20}
}

@article{paloneva2003-12925681,
  author  = {Paloneva, J. and Mandelin, J. and Kiialainen, A. and Bohling, T. and Prudlo, J. and Hakola, P. and Haltia, M. and Konttinen, Y. T. and others},
  title   = {{DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features}},
  journal = {The Journal of experimental medicine},
  year    = {2003},
  doi     = {10.1084/jem.20030027},
  pmid    = {12925681},
  url     = {https://doi.org/10.1084/jem.20030027}
}

@article{bemiller2017-29037207,
  author  = {Bemiller, S. M. and McCray, T. J. and Allan, K. and Formica, S. V. and Xu, G. and Wilson, G. and Kokiko-Cochran, O. N. and Crish, S. D. and others},
  title   = {{TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0216-6},
  pmid    = {29037207},
  url     = {https://doi.org/10.1186/s13024-017-0216-6}
}

@article{zhu2021-33844047,
  author  = {Zhu, D. and Montagne, A. and Zhao, Z.},
  title   = {{Alzheimer's pathogenic mechanisms and underlying sex difference}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2021},
  doi     = {10.1007/s00018-021-03830-w},
  pmid    = {33844047},
  url     = {https://doi.org/10.1007/s00018-021-03830-w}
}

@article{he2021-34040149,
  author  = {He, L. and Davila-Velderrain, J. and Sumida, T. S. and Hafler, D. A. and Kellis, M. and Kulminski, A. M.},
  title   = {{NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data}},
  journal = {Communications biology},
  year    = {2021},
  doi     = {10.1038/s42003-021-02146-6},
  pmid    = {34040149},
  url     = {https://doi.org/10.1038/s42003-021-02146-6}
}

@article{lewcock2020-33096024,
  author  = {Lewcock, J. W. and Schlepckow, K. and Di Paolo, G. and Tahirovic, S. and Monroe, K. M. and Haass, C.},
  title   = {{Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2020.09.029},
  pmid    = {33096024},
  url     = {https://doi.org/10.1016/j.neuron.2020.09.029}
}

@article{hou2022-36564824,
  author  = {Hou, J. and Chen, Y. and Grajales-Reyes, G. and Colonna, M.},
  title   = {{TREM2 dependent and independent functions of microglia in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00588-y},
  pmid    = {36564824},
  url     = {https://doi.org/10.1186/s13024-022-00588-y}
}

@article{zernecke2023-36190844,
  author  = {Zernecke, A. and Erhard, F. and Weinberger, T. and Schulz, C. and Ley, K. and Saliba, A. E. and Cochain, C.},
  title   = {{Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis}},
  journal = {Cardiovascular research},
  year    = {2023},
  doi     = {10.1093/cvr/cvac161},
  pmid    = {36190844},
  url     = {https://doi.org/10.1093/cvr/cvac161}
}

@article{xiong2020-33033253,
  author  = {Xiong, D. and Wang, Y. and You, M.},
  title   = {{A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-18546-x},
  pmid    = {33033253},
  url     = {https://doi.org/10.1038/s41467-020-18546-x}
}

@article{zhao2022-36070367,
  author  = {Zhao, P. and Xu, Y. and Jiang, L. and Fan, X. and Li, L. and Li, X. and Arase, H. and Zhao, Y. and others},
  title   = {{A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease}},
  journal = {Science translational medicine},
  year    = {2022},
  doi     = {10.1126/scitranslmed.abq0095},
  pmid    = {36070367},
  url     = {https://doi.org/10.1126/scitranslmed.abq0095}
}

@article{giraldo2013-23582655,
  author  = {Giraldo, M. and Lopera, F. and Siniard, A. L. and Corneveaux, J. J. and Schrauwen, I. and Carvajal, J. and Muñoz, C. and Ramirez-Restrepo, M. and others},
  title   = {{Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.02.016},
  pmid    = {23582655},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.02.016}
}

@article{ellwanger2021-33446504,
  author  = {Ellwanger, D. C. and Wang, S. and Brioschi, S. and Shao, Z. and Green, L. and Case, R. and Yoo, D. and Weishuhn, D. and others},
  title   = {{Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2017742118},
  pmid    = {33446504},
  url     = {https://doi.org/10.1073/pnas.2017742118}
}

@article{sung2023-37406134,
  author  = {Sung, Y. J. and Yang, C. and Norton, J. and Johnson, M. and Fagan, A. and Bateman, R. J. and Perrin, R. J. and Morris, J. C. and others},
  title   = {{Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease}},
  journal = {Science translational medicine},
  year    = {2023},
  doi     = {10.1126/scitranslmed.abq5923},
  pmid    = {37406134},
  url     = {https://doi.org/10.1126/scitranslmed.abq5923}
}

@article{beckmann2018-29448957,
  author  = {Beckmann, N. and Giorgetti, E. and Neuhaus, A. and Zurbruegg, S. and Accart, N. and Smith, P. and Perdoux, J. and Perrot, L. and others},
  title   = {{Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945}},
  journal = {Acta neuropathologica communications},
  year    = {2018},
  doi     = {10.1186/s40478-018-0510-8},
  pmid    = {29448957},
  url     = {https://doi.org/10.1186/s40478-018-0510-8}
}

@article{zhang2023-37865646,
  author  = {Zhang, X. and Tang, L. and Yang, J. and Meng, L. and Chen, J. and Zhou, L. and Wang, J. and Xiong, M. and others},
  title   = {{Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-42505-x},
  pmid    = {37865646},
  url     = {https://doi.org/10.1038/s41467-023-42505-x}
}

@article{yang2023-37735198,
  author  = {Yang, X. and Wen, J. and Yang, H. and Jones, I. R. and Zhu, X. and Liu, W. and Li, B. and Clelland, C. D. and others},
  title   = {{Functional characterization of Alzheimer's disease genetic variants in microglia}},
  journal = {Nature genetics},
  year    = {2023},
  doi     = {10.1038/s41588-023-01506-8},
  pmid    = {37735198},
  url     = {https://doi.org/10.1038/s41588-023-01506-8}
}

@article{zhao2022-36519540,
  author  = {Zhao, A. and Jiao, Y. and Ye, G. and Kang, W. and Tan, L. and Li, Y. and Deng, Y. and Liu, J. and others},
  title   = {{Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease}},
  journal = {The Journal of clinical investigation},
  year    = {2022},
  doi     = {10.1172/jci158708},
  pmid    = {36519540},
  url     = {https://doi.org/10.1172/jci158708}
}

@article{tesi2019-30258121,
  author  = {Tesi, N. and van der Lee, S. J. and Hulsman, M. and Jansen, I. E. and Stringa, N. and van Schoor, N. and Meijers-Heijboer, H. and Huisman, M. and others},
  title   = {{Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease}},
  journal = {European journal of human genetics : EJHG},
  year    = {2019},
  doi     = {10.1038/s41431-018-0273-5},
  pmid    = {30258121},
  url     = {https://doi.org/10.1038/s41431-018-0273-5}
}

@article{zou2025-40791247,
  author  = {Zou, B. and Xiang, J. and Zhang, M. and Huang, J. and Feng, C.},
  title   = {{A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024}},
  journal = {Frontiers in aging neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1587575},
  pmid    = {40791247},
  url     = {https://doi.org/10.3389/fnagi.2025.1587575}
}

@article{wang2018-29256968,
  author  = {Wang, Ping and Guo, Qihao and Zhou, Yan and Chen, Keliang and Xu, Yan and Ding, Ding and Hong, Zhen and Zhao, Qianhua},
  title   = {{Lack of association between triggering receptor expressed on myeloid cells 2 polymorphism rs75932628 and late-onset Alzheimer's disease in a Chinese Han population}},
  journal = {Psychiatric genetics},
  year    = {2018},
  doi     = {10.1097/ypg.0000000000000188},
  pmid    = {29256968},
  url     = {https://doi.org/10.1097/ypg.0000000000000188}
}

@article{rodriguezgomez2020-32709045,
  author  = {Rodríguez-Gómez, J. A. and Kavanagh, E. and Engskog-Vlachos, P. and Engskog, M. K. R. and Herrera, A. J. and Espinosa-Oliva, A. M. and Joseph, B. and Hajji, N. and others},
  title   = {{Microglia: Agents of the CNS Pro-Inflammatory Response}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9071717},
  pmid    = {32709045},
  url     = {https://doi.org/10.3390/cells9071717}
}

@article{jiang2014-25047746,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhang, Q. Q. and Cao, L. and Tan, M. S. and Gu, L. Z. and Wang, H. F. and others},
  title   = {{Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2014},
  doi     = {10.1038/npp.2014.164},
  pmid    = {25047746},
  url     = {https://doi.org/10.1038/npp.2014.164}
}

@article{lee2021-33675684,
  author  = {Lee, S. H. and Meilandt, W. J. and Xie, L. and Gandham, V. D. and Ngu, H. and Barck, K. H. and Rezzonico, M. G. and Imperio, J. and others},
  title   = {{Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2021.02.010},
  pmid    = {33675684},
  url     = {https://doi.org/10.1016/j.neuron.2021.02.010}
}

@article{cuyvers2016-27302364,
  author  = {Cuyvers, E. and Sleegers, K.},
  title   = {{Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond}},
  journal = {The Lancet. Neurology},
  year    = {2016},
  doi     = {10.1016/s1474-4422(16)00127-7},
  pmid    = {27302364},
  url     = {https://doi.org/10.1016/s1474-4422(16)00127-7}
}

@article{willemsen2020-32003464,
  author  = {Willemsen, L. and de Winther, M. P.},
  title   = {{Macrophage subsets in atherosclerosis as defined by single-cell technologies}},
  journal = {The Journal of pathology},
  year    = {2020},
  doi     = {10.1002/path.5392},
  pmid    = {32003464},
  url     = {https://doi.org/10.1002/path.5392}
}

@article{kober2016-27995897,
  author  = {Kober, D. L. and Alexander-Brett, J. M. and Karch, C. M. and Cruchaga, C. and Colonna, M. and Holtzman, M. J. and Brett, T. J.},
  title   = {{Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms}},
  journal = {eLife},
  year    = {2016},
  doi     = {10.7554/elife.20391},
  pmid    = {27995897},
  url     = {https://doi.org/10.7554/elife.20391}
}

@article{frank2008-18551625,
  author  = {Frank, S. and Burbach, G. J. and Bonin, M. and Walter, M. and Streit, W. and Bechmann, I. and Deller, T.},
  title   = {{TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice}},
  journal = {Glia},
  year    = {2008},
  doi     = {10.1002/glia.20710},
  pmid    = {18551625},
  url     = {https://doi.org/10.1002/glia.20710}
}

@article{hendrikx2022-35750138,
  author  = {Hendrikx, T. and Porsch, F. and Kiss, M. G. and Rajcic, D. and Papac-Miličević, N. and Hoebinger, C. and Goederle, L. and Hladik, A. and others},
  title   = {{Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH}},
  journal = {Journal of hepatology},
  year    = {2022},
  doi     = {10.1016/j.jhep.2022.06.004},
  pmid    = {35750138},
  url     = {https://doi.org/10.1016/j.jhep.2022.06.004}
}

@article{liu2020-32959884,
  author  = {Liu, W. and Taso, O. and Wang, R. and Bayram, S. and Graham, A. C. and Garcia-Reitboeck, P. and Mallach, A. and Andrews, W. D. and others},
  title   = {{Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions}},
  journal = {Human molecular genetics},
  year    = {2020},
  doi     = {10.1093/hmg/ddaa209},
  pmid    = {32959884},
  url     = {https://doi.org/10.1093/hmg/ddaa209}
}

@article{li2022-35658903,
  author  = {Li, R. Y. and Qin, Q. and Yang, H. C. and Wang, Y. Y. and Mi, Y. X. and Yin, Y. S. and Wang, M. and Yu, C. J. and others},
  title   = {{TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00542-y},
  pmid    = {35658903},
  url     = {https://doi.org/10.1186/s13024-022-00542-y}
}

@article{zhong2018-29587871,
  author  = {Zhong, L. and Wang, Z. and Wang, D. and Martens, Y. A. and Wu, L. and Xu, Y. and Wang, K. and others},
  title   = {{Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0247-7},
  pmid    = {29587871},
  url     = {https://doi.org/10.1186/s13024-018-0247-7}
}

@article{bancaro2023-36868226,
  author  = {Bancaro, N. and Calì, B. and Troiani, M. and Elia, A. R. and Arzola, R. A. and Attanasio, G. and Lai, P. and Crespo, M. and others},
  title   = {{Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer}},
  journal = {Cancer cell},
  year    = {2023},
  doi     = {10.1016/j.ccell.2023.02.004},
  pmid    = {36868226},
  url     = {https://doi.org/10.1016/j.ccell.2023.02.004}
}

@article{wang2019-30930146,
  author  = {Wang, E. C. E. and Dai, Z. and Ferrante, A. W. and Drake, C. G. and Christiano, A. M.},
  title   = {{A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth}},
  journal = {Cell stem cell},
  year    = {2019},
  doi     = {10.1016/j.stem.2019.01.011},
  pmid    = {30930146},
  url     = {https://doi.org/10.1016/j.stem.2019.01.011}
}

@article{forabosco2013-23855984,
  author  = {Forabosco, P. and Ramasamy, A. and Trabzuni, D. and Walker, R. and Smith, C. and Bras, J. and Levine, A. P. and Hardy, J. and others},
  title   = {{Insights into TREM2 biology by network analysis of human brain gene expression data}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.05.001},
  pmid    = {23855984},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.05.001}
}

@article{zhong2023-37442133,
  author  = {Zhong, L. and Sheng, X. and Wang, W. and Li, Y. and Zhuo, R. and Wang, K. and Zhang, L. and Hu, D. D. and others},
  title   = {{TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration}},
  journal = {Immunity},
  year    = {2023},
  doi     = {10.1016/j.immuni.2023.06.016},
  pmid    = {37442133},
  url     = {https://doi.org/10.1016/j.immuni.2023.06.016}
}

@article{price2020-32795308,
  author  = {Price, B. R. and Sudduth, T. L. and Weekman, E. M. and Johnson, S. and Hawthorne, D. and Woolums, A. and Wilcock, D. M.},
  title   = {{Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01915-0},
  pmid    = {32795308},
  url     = {https://doi.org/10.1186/s12974-020-01915-0}
}

@article{fol2016-26538149,
  author  = {Fol, R. and Braudeau, J. and Ludewig, S. and Abel, T. and Weyer, S. W. and Roederer, J. P. and Brod, F. and others},
  title   = {{Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-015-1498-9},
  pmid    = {26538149},
  url     = {https://doi.org/10.1007/s00401-015-1498-9}
}

@article{fitz2021-34099706,
  author  = {Fitz, N. F. and Nam, K. N. and Wolfe, C. M. and Letronne, F. and Playso, B. E. and Iordanova, B. E. and Kozai, T. D. Y. and Biedrzycki, R. J. and others},
  title   = {{Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-23762-0},
  pmid    = {34099706},
  url     = {https://doi.org/10.1038/s41467-021-23762-0}
}

@article{filipello2022-35041990,
  author  = {Filipello, F. and Goldsbury, C. and You, S. F. and Locca, A. and Karch, C. M. and Piccio, L.},
  title   = {{Soluble TREM2: Innocent bystander or active player in neurological diseases?}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105630},
  pmid    = {35041990},
  url     = {https://doi.org/10.1016/j.nbd.2022.105630}
}

@article{sun2023-37172094,
  author  = {Sun, R. and Han, R. and McCornack, C. and Khan, S. and Tabor, G. T. and Chen, Y. and Hou, J. and Jiang, H. and others},
  title   = {{TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma}},
  journal = {Science advances},
  year    = {2023},
  doi     = {10.1126/sciadv.ade3559},
  pmid    = {37172094},
  url     = {https://doi.org/10.1126/sciadv.ade3559}
}

@article{gotzl2019-31122931,
  author  = {Götzl, J. K. and Brendel, M. and Werner, G. and Parhizkar, S. and Sebastian Monasor, L. and Kleinberger, G. and Colombo, A. V. and Deussing, M. and others},
  title   = {{Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism}},
  journal = {EMBO molecular medicine},
  year    = {2019},
  doi     = {10.15252/emmm.201809711},
  pmid    = {31122931},
  url     = {https://doi.org/10.15252/emmm.201809711}
}

@article{hauremirande2017-28612290,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Fanutza, T. and Kim, S. H. and Klein, W. L. and Glabe, C. and Readhead, B. and Dudley, J. T. and others},
  title   = {{Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology}},
  journal = {Acta neuropathologica},
  year    = {2017},
  doi     = {10.1007/s00401-017-1737-3},
  pmid    = {28612290},
  url     = {https://doi.org/10.1007/s00401-017-1737-3}
}

@article{gong2024-38182899,
  author  = {Gong, S. and Zhai, M. and Shi, J. and Yu, G. and Lei, Z. and Shi, Y. and Zeng, Y. and Ju, P. and others},
  title   = {{TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53}},
  journal = {Cell death and differentiation},
  year    = {2024},
  doi     = {10.1038/s41418-023-01252-8},
  pmid    = {38182899},
  url     = {https://doi.org/10.1038/s41418-023-01252-8}
}

@article{parhizkar2023-37099634,
  author  = {Parhizkar, S. and Gent, G. and Chen, Y. and Rensing, N. and Gratuze, M. and Strout, G. and Sviben, S. and Tycksen, E. and others},
  title   = {{Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice}},
  journal = {Science translational medicine},
  year    = {2023},
  doi     = {10.1126/scitranslmed.ade6285},
  pmid    = {37099634},
  url     = {https://doi.org/10.1126/scitranslmed.ade6285}
}

@article{gispert2016-27423963,
  author  = {Gispert, J. D. and Suárez-Calvet, M. and Monté, G. C. and Tucholka, A. and Falcon, C. and Rojas, S. and Rami, L. and Sánchez-Valle, R. and others},
  title   = {{Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.06.005},
  pmid    = {27423963},
  url     = {https://doi.org/10.1016/j.jalz.2016.06.005}
}

@article{yoo2023-37541210,
  author  = {Yoo, Y. and Neumayer, G. and Shibuya, Y. and Mader, M. M. and Wernig, M.},
  title   = {{A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease}},
  journal = {Cell stem cell},
  year    = {2023},
  doi     = {10.1016/j.stem.2023.07.006},
  pmid    = {37541210},
  url     = {https://doi.org/10.1016/j.stem.2023.07.006}
}

@article{reifschneider2022-35019161,
  author  = {Reifschneider, A. and Robinson, S. and van Lengerich, B. and Gnörich, J. and Logan, T. and Heindl, S. and Vogt, M. A. and Weidinger, E. and others},
  title   = {{Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency}},
  journal = {The EMBO journal},
  year    = {2022},
  doi     = {10.15252/embj.2021109108},
  pmid    = {35019161},
  url     = {https://doi.org/10.15252/embj.2021109108}
}

@article{leber2014-24910390,
  author  = {Le Ber, I. and De Septenville, A. and Guerreiro, R. and Bras, J. and Camuzat, A. and Caroppo, P. and Lattante, S. and Couarch, P. and others},
  title   = {{Homozygous TREM2 mutation in a family with atypical frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.04.010},
  pmid    = {24910390},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.04.010}
}

@article{guimaraes2024-38972873,
  author  = {Guimarães, G. R. and Maklouf, G. R. and Teixeira, C. E. and de Oliveira Santos, L. and Tessarollo, N. G. and de Toledo, N. E. and Serain, A. F. and de Lanna, C. A. and others},
  title   = {{Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-49916-4},
  pmid    = {38972873},
  url     = {https://doi.org/10.1038/s41467-024-49916-4}
}

@article{vilalta2021-33823153,
  author  = {Vilalta, A. and Zhou, Y. and Sevalle, J. and Griffin, J. K. and Satoh, K. and Allendorf, D. H. and De, S. and Puigdellívol, M. and others},
  title   = {{Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation}},
  journal = {The Journal of biological chemistry},
  year    = {2021},
  doi     = {10.1016/j.jbc.2021.100631},
  pmid    = {33823153},
  url     = {https://doi.org/10.1016/j.jbc.2021.100631}
}

@article{gisslen2019-30568991,
  author  = {Gisslén, M. and Heslegrave, A. and Veleva, E. and Yilmaz, A. and Andersson, L. M. and Hagberg, L. and Spudich, S. and Fuchs, D. and others},
  title   = {{CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection}},
  journal = {Neurology(R) neuroimmunology \& neuroinflammation},
  year    = {2019},
  doi     = {10.1212/nxi.0000000000000512},
  pmid    = {30568991},
  url     = {https://doi.org/10.1212/nxi.0000000000000512}
}

@article{deponti2025-39862865,
  author  = {De Ponti, F. F. and Bujko, A. and Liu, Z. and Collins, P. J. and Schuermans, S. and Maueroder, C. and Amstelveen, S. and Thoné, T. and others},
  title   = {{Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair}},
  journal = {Immunity},
  year    = {2025},
  doi     = {10.1016/j.immuni.2025.01.002},
  pmid    = {39862865},
  url     = {https://doi.org/10.1016/j.immuni.2025.01.002}
}

@article{zhang2025-40247363,
  author  = {Zhang, L. and Xiang, X. and Li, Y. and Bu, G. and Chen, X. F.},
  title   = {{TREM2 and sTREM2 in Alzheimer's disease: from mechanisms to therapies}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00834-z},
  pmid    = {40247363},
  url     = {https://doi.org/10.1186/s13024-025-00834-z}
}

@article{carling2024-39353433,
  author  = {Carling, G. K. and Fan, L. and Foxe, N. R. and Norman, K. and Wong, M. Y. and Zhu, D. and Corona, C. and Razzoli, A. and others},
  title   = {{Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model}},
  journal = {Neuron},
  year    = {2024},
  doi     = {10.1016/j.neuron.2024.09.006},
  pmid    = {39353433},
  url     = {https://doi.org/10.1016/j.neuron.2024.09.006}
}

@article{yu2024-38289348,
  author  = {Yu, C. and Lad, E. M. and Mathew, R. and Shiraki, N. and Littleton, S. and Chen, Y. and Hou, J. and Schlepckow, K. and others},
  title   = {{Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231011},
  pmid    = {38289348},
  url     = {https://doi.org/10.1084/jem.20231011}
}

@article{batista2024-38255891,
  author  = {Batista, A. F. and Khan, K. A. and Papavergi, M. T. and Lemere, C. A.},
  title   = {{The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25020817},
  pmid    = {38255891},
  url     = {https://doi.org/10.3390/ijms25020817}
}

@article{ardighieri2021-34220848,
  author  = {Ardighieri, L. and Missale, F. and Bugatti, M. and Gatta, L. B. and Pezzali, I. and Monti, M. and Gottardi, S. and Zanotti, L. and others},
  title   = {{Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.690201},
  pmid    = {34220848},
  url     = {https://doi.org/10.3389/fimmu.2021.690201}
}

@article{yu2014-24184202,
  author  = {Yu, J. T. and Jiang, T. and Wang, Y. L. and Wang, H. F. and Zhang, W. and Hu, N. and Tan, L. and Sun, L. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.10.075},
  pmid    = {24184202},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.10.075}
}

@article{dzobo2024-38269588,
  author  = {Dzobo, K. E. and Cupido, A. J. and Mol, B. M. and Stiekema, L. C. A. and Versloot, M. and Winkelmeijer, M. and Peter, J. and Pennekamp, A. M. and others},
  title   = {{Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2024},
  doi     = {10.1161/atvbaha.123.319937},
  pmid    = {38269588},
  url     = {https://doi.org/10.1161/atvbaha.123.319937}
}

@article{su2018-29322490,
  author  = {Su, W. H. and Shi, Z. H. and Liu, S. L. and Wang, X. D. and Liu, S. and Ji, Y.},
  title   = {{The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations}},
  journal = {Annals of human genetics},
  year    = {2018},
  doi     = {10.1111/ahg.12241},
  pmid    = {29322490},
  url     = {https://doi.org/10.1111/ahg.12241}
}

@article{reitz2013-1f8a1527,
  author  = {Reitz, Christiane and Mayeux, Richard P},
  title   = {{TREM2 and Neurodegenerative Disease}},
  journal = {New England Journal of Medicine},
  year    = {2013},
  doi     = {10.1056/nejmc1306509},
  url     = {https://doi.org/10.1056/nejmc1306509}
}

@article{colonna2003-12776204,
  author  = {Colonna, M.},
  title   = {{TREMs in the immune system and beyond}},
  journal = {Nature reviews. Immunology},
  year    = {2003},
  doi     = {10.1038/nri1106},
  pmid    = {12776204},
  url     = {https://doi.org/10.1038/nri1106}
}

@article{konishi2018-30127720,
  author  = {Konishi, H. and Kiyama, H.},
  title   = {{Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2018},
  doi     = {10.3389/fncel.2018.00206},
  pmid    = {30127720},
  url     = {https://doi.org/10.3389/fncel.2018.00206}
}

@article{tan2023-36889359,
  author  = {Tan, J. and Fan, W. and Liu, T. and Zhu, B. and Liu, Y. and Wang, S. and Wu, J. and Liu, J. and others},
  title   = {{TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma}},
  journal = {Journal of hepatology},
  year    = {2023},
  doi     = {10.1016/j.jhep.2023.02.032},
  pmid    = {36889359},
  url     = {https://doi.org/10.1016/j.jhep.2023.02.032}
}

@article{patterson2023-38646596,
  author  = {Patterson, M. T. and Firulyova, M. M. and Xu, Y. and Hillman, H. and Bishop, C. and Zhu, A. and Hickok, G. H. and Schrank, P. R. and others},
  title   = {{Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis}},
  journal = {Nature cardiovascular research},
  year    = {2023},
  doi     = {10.1038/s44161-023-00354-3},
  pmid    = {38646596},
  url     = {https://doi.org/10.1038/s44161-023-00354-3}
}

@article{thornton2017-28855301,
  author  = {Thornton, P. and Sevalle, J. and Deery, M. J. and Fraser, G. and Zhou, Y. and Ståhl, S. and Franssen, E. H. and Dodd, R. B. and others},
  title   = {{TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201707673},
  pmid    = {28855301},
  url     = {https://doi.org/10.15252/emmm.201707673}
}

@article{meilandt2020-31980586,
  author  = {Meilandt, W. J. and Ngu, H. and Gogineni, A. and Lalehzadeh, G. and Lee, S. H. and Srinivasan, K. and Imperio, J. and Wu, T. and others},
  title   = {{Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.1871-19.2019},
  pmid    = {31980586},
  url     = {https://doi.org/10.1523/jneurosci.1871-19.2019}
}

@article{otero2012-22312126,
  author  = {Otero, K. and Shinohara, M. and Zhao, H. and Cella, M. and Gilfillan, S. and Colucci, A. and Faccio, R. and Ross, F. P. and others},
  title   = {{TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2012},
  doi     = {10.4049/jimmunol.1102836},
  pmid    = {22312126},
  url     = {https://doi.org/10.4049/jimmunol.1102836}
}

@article{hauremirande2022-36002854,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Ehrlich, M. E. and Gandy, S.},
  title   = {{Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00552-w},
  pmid    = {36002854},
  url     = {https://doi.org/10.1186/s13024-022-00552-w}
}

@article{painter2015-26337043,
  author  = {Painter, M. M. and Atagi, Y. and Liu, C. C. and Rademakers, R. and Xu, H. and Fryer, J. D. and Bu, G.},
  title   = {{TREM2 in CNS homeostasis and neurodegenerative disease}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0040-9},
  pmid    = {26337043},
  url     = {https://doi.org/10.1186/s13024-015-0040-9}
}

@article{castillo2017-29259249,
  author  = {Castillo, E. and Leon, J. and Mazzei, G. and Abolhassani, N. and Haruyama, N. and Saito, T. and Saido, T. and Hokama, M. and others},
  title   = {{Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-17999-3},
  pmid    = {29259249},
  url     = {https://doi.org/10.1038/s41598-017-17999-3}
}

@article{lessard2018-30341064,
  author  = {Lessard, C. B. and Malnik, S. L. and Zhou, Y. and Ladd, T. B. and Cruz, P. E. and Ran, Y. and Mahan, T. E. and Chakrabaty, P. and others},
  title   = {{High-affinity interactions and signal transduction between Aβ oligomers and TREM2}},
  journal = {EMBO molecular medicine},
  year    = {2018},
  doi     = {10.15252/emmm.201809027},
  pmid    = {30341064},
  url     = {https://doi.org/10.15252/emmm.201809027}
}

@article{bhattacharjee2016-26949937,
  author  = {Bhattacharjee, S. and Zhao, Y. and Dua, P. and Rogaev, E. I. and Lukiw, W. J.},
  title   = {{microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration}},
  journal = {PloS one},
  year    = {2016},
  doi     = {10.1371/journal.pone.0150211},
  pmid    = {26949937},
  url     = {https://doi.org/10.1371/journal.pone.0150211}
}

@article{qiu2021-34526055,
  author  = {Qiu, S. and Palavicini, J. P. and Wang, J. and Gonzalez, N. S. and He, S. and Dustin, E. and Zou, C. and Ding, L. and others},
  title   = {{Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00488-7},
  pmid    = {34526055},
  url     = {https://doi.org/10.1186/s13024-021-00488-7}
}

@article{guerreiro2013-23870839,
  author  = {Guerreiro, R. and Bilgic, B. and Guven, G. and Brás, J. and Rohrer, J. and Lohmann, E. and Hanagasi, H. and Gurvit, H. and others},
  title   = {{Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.06.005},
  pmid    = {23870839},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.06.005}
}

@article{yofe2023-37756565,
  author  = {Yofe, I. and Shami, T. and Cohen, N. and Landsberger, T. and Sheban, F. and Stoler-Barak, L. and Yalin, A. and Phan, T. S. and others},
  title   = {{Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary}},
  journal = {Cancer discovery},
  year    = {2023},
  doi     = {10.1158/2159-8290.cd-23-0299},
  pmid    = {37756565},
  url     = {https://doi.org/10.1158/2159-8290.cd-23-0299}
}

@article{jiang2024-38649866,
  author  = {Jiang, S. and Cai, G. and Yang, Z. and Shi, H. and Zeng, H. and Ye, Q. and Hu, Z. and Wang, Z.},
  title   = {{Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease}},
  journal = {ACS nano},
  year    = {2024},
  doi     = {10.1021/acsnano.3c13150},
  pmid    = {38649866},
  url     = {https://doi.org/10.1021/acsnano.3c13150}
}

@article{prokop2019-31350575,
  author  = {Prokop, S. and Miller, K. R. and Labra, SR. and Pitkin, R. M. and Hoxha, K. and Narasimhan, S. and Changolkar, L. and Rosenbloom, A. and others},
  title   = {{Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02048-2},
  pmid    = {31350575},
  url     = {https://doi.org/10.1007/s00401-019-02048-2}
}

@article{shirotani2019-31101881,
  author  = {Shirotani, K. and Hori, Y. and Yoshizaki, R. and Higuchi, E. and Colonna, M. and Saito, T. and Hashimoto, S. and others},
  title   = {{Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-43535-6},
  pmid    = {31101881},
  url     = {https://doi.org/10.1038/s41598-019-43535-6}
}

@article{huang2024-37917301,
  author  = {Huang, P. and Zhang, Z. and Zhang, P. and Feng, J. and Xie, J. and Zheng, Y. and Liang, X. and Zhu, B. and others},
  title   = {{TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells}},
  journal = {Molecular neurobiology},
  year    = {2024},
  doi     = {10.1007/s12035-023-03713-0},
  pmid    = {37917301},
  url     = {https://doi.org/10.1007/s12035-023-03713-0}
}

@article{ohrfelt2016-26754805,
  author  = {Öhrfelt, A. and Axelsson, M. and Malmeström, C. and Novakova, L. and Heslegrave, A. and Blennow, K. and Lycke, J. and Zetterberg, H.},
  title   = {{Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone}},
  journal = {Multiple sclerosis (Houndmills, Basingstoke, England)},
  year    = {2016},
  doi     = {10.1177/1352458515624558},
  pmid    = {26754805},
  url     = {https://doi.org/10.1177/1352458515624558}
}

@article{ma2020-32276587,
  author  = {Ma, L. Z. and Tan, L. and Bi, Y. L. and Shen, X. N. and Xu, W. and Ma, Y. H. and Li, H. Q. and Dong, Q. and others},
  title   = {{Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00374-8},
  pmid    = {32276587},
  url     = {https://doi.org/10.1186/s13024-020-00374-8}
}

@article{yashaswini2024-38508241,
  author  = {Yashaswini, C. N. and Qin, T. and Bhattacharya, D. and Amor, C. and Lowe, S. and Lujambio, A. and Wang, S. and Friedman, S. L.},
  title   = {{Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatohepatitis}},
  journal = {Journal of hepatology},
  year    = {2024},
  doi     = {10.1016/j.jhep.2024.03.014},
  pmid    = {38508241},
  url     = {https://doi.org/10.1016/j.jhep.2024.03.014}
}

@article{liu2020-32941599,
  author  = {Liu, T. and Zhu, B. and Liu, Y. and Zhang, X. and Yin, J. and Li, X. and Jiang, L. and Hodges, A. P. and others},
  title   = {{Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE}},
  journal = {The Journal of experimental medicine},
  year    = {2020},
  doi     = {10.1084/jem.20200474},
  pmid    = {32941599},
  url     = {https://doi.org/10.1084/jem.20200474}
}

@article{jung2025-40149001,
  author  = {Jung, E. S. and Choi, H. and Mook-Jung, I.},
  title   = {{Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00825-0},
  pmid    = {40149001},
  url     = {https://doi.org/10.1186/s13024-025-00825-0}
}

@article{zhou2023-36658241,
  author  = {Zhou, Y. and Tada, M. and Cai, Z. and Andhey, P. S. and Swain, A. and Miller, K. R. and Gilfillan, S. and Artyomov, M. N. and others},
  title   = {{Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-022-01403-y},
  pmid    = {36658241},
  url     = {https://doi.org/10.1038/s41590-022-01403-y}
}

@article{kotredes2021-34707490,
  author  = {Kotredes, K. P. and Oblak, A. and Pandey, R. S. and Lin, P. B. and Garceau, D. and Williams, H. and Uyar, A. and O'Rourke, R. and others},
  title   = {{Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.735524},
  pmid    = {34707490},
  url     = {https://doi.org/10.3389/fnagi.2021.735524}
}

@article{miyashita2023-35641666,
  author  = {Miyashita, A. and Kikuchi, M. and Hara, N. and Ikeuchi, T.},
  title   = {{Genetics of Alzheimer's disease: an East Asian perspective}},
  journal = {Journal of human genetics},
  year    = {2023},
  doi     = {10.1038/s10038-022-01050-z},
  pmid    = {35641666},
  url     = {https://doi.org/10.1038/s10038-022-01050-z}
}

@article{demuynck2024-37535809,
  author  = {De Muynck, K. and Heyerick, L. and De Ponti, F. F. and Vanderborght, B. and Meese, T. and Van Campenhout, S. and Baudonck, L. and Gijbels, E. and others},
  title   = {{Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis}},
  journal = {Hepatology (Baltimore, Md.)},
  year    = {2024},
  doi     = {10.1097/hep.0000000000000557},
  pmid    = {37535809},
  url     = {https://doi.org/10.1097/hep.0000000000000557}
}

@article{belsare2022-35082148,
  author  = {Belsare, K. D. and Wu, H. and Mondal, D. and Bond, A. and Castillo, E. and Jin, J. and Jo, H. and Roush, A. E. and others},
  title   = {{Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2022},
  doi     = {10.1073/pnas.2114486119},
  pmid    = {35082148},
  url     = {https://doi.org/10.1073/pnas.2114486119}
}

@article{liao2026-42230432,
  author  = {Liao, Y. and Ye, S. and Zhao, L. and Zhou, M. and Wen, Y. and Zhu, Y. and Huang, J. and Zhang, L. and others},
  title   = {{Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies}},
  journal = {Molecular neurobiology},
  year    = {2026},
  doi     = {10.1007/s12035-026-05925-6},
  pmid    = {42230432},
  url     = {https://doi.org/10.1007/s12035-026-05925-6}
}

@article{yin2024-38915213,
  author  = {Yin, Y. and Yang, H. and Li, R. and Wu, G. and Qin, Q. and Tang, Y.},
  title   = {{A systematic review of the role of TREM2 in Alzheimer's disease}},
  journal = {Chinese medical journal},
  year    = {2024},
  doi     = {10.1097/cm9.0000000000003000},
  pmid    = {38915213},
  url     = {https://doi.org/10.1097/cm9.0000000000003000}
}

@article{lu2015-26037549,
  author  = {Lu, Y. and Liu, W. and Wang, X.},
  title   = {{TREM2 variants and risk of Alzheimer's disease: a meta-analysis}},
  journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
  year    = {2015},
  doi     = {10.1007/s10072-015-2274-2},
  pmid    = {26037549},
  url     = {https://doi.org/10.1007/s10072-015-2274-2}
}

@article{diazlucena2021-33881612,
  author  = {Diaz-Lucena, Daniela and Kruse, Niels and Thüne, Katrin and Schmitz, Matthias and Villar-Piqué, Anna and da Cunha, Jose Eriton Gomes and Hermann, Peter and López-Pérez, Óscar and others},
  title   = {{TREM2 expression in the brain and biological fluids in prion diseases}},
  journal = {Acta neuropathologica},
  year    = {2021},
  doi     = {10.1007/s00401-021-02296-1},
  pmid    = {33881612},
  url     = {https://doi.org/10.1007/s00401-021-02296-1}
}

@article{zhang2019-31590042,
  author  = {Zhang, J. and Zheng, Y. and Luo, Y. and Du, Y. and Zhang, X. and Fu, J.},
  title   = {{Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells}},
  journal = {Molecular immunology},
  year    = {2019},
  doi     = {10.1016/j.molimm.2019.09.020},
  pmid    = {31590042},
  url     = {https://doi.org/10.1016/j.molimm.2019.09.020}
}

@article{peng2010-20484116,
  author  = {Peng, Q. and Malhotra, S. and Torchia, J. A. and Kerr, W. G. and Coggeshall, K. M. and Humphrey, M. B.},
  title   = {{TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1}},
  journal = {Science signaling},
  year    = {2010},
  doi     = {10.1126/scisignal.2000500},
  pmid    = {20484116},
  url     = {https://doi.org/10.1126/scisignal.2000500}
}

@article{yeh2017-28442216,
  author  = {Yeh, F. L. and Hansen, D. V. and Sheng, M.},
  title   = {{TREM2, Microglia, and Neurodegenerative Diseases}},
  journal = {Trends in molecular medicine},
  year    = {2017},
  doi     = {10.1016/j.molmed.2017.03.008},
  pmid    = {28442216},
  url     = {https://doi.org/10.1016/j.molmed.2017.03.008}
}

@article{kierdorf2013-23630462,
  author  = {Kierdorf, K. and Prinz, M.},
  title   = {{Factors regulating microglia activation}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2013},
  doi     = {10.3389/fncel.2013.00044},
  pmid    = {23630462},
  url     = {https://doi.org/10.3389/fncel.2013.00044}
}

@article{matarin2015-25620700,
  author  = {Matarin, M. and Salih, D. A. and Yasvoina, M. and Cummings, D. M. and Guelfi, S. and Liu, W. and Nahaboo Solim, M. A. and Moens, T. G. and others},
  title   = {{A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology}},
  journal = {Cell reports},
  year    = {2015},
  doi     = {10.1016/j.celrep.2014.12.041},
  pmid    = {25620700},
  url     = {https://doi.org/10.1016/j.celrep.2014.12.041}
}

@article{andreone2020-32514138,
  author  = {Andreone, B. J. and Przybyla, L. and Llapashtica, C. and Rana, A. and Davis, S. S. and van Lengerich, B. and Lin, K. and Shi, J. and others},
  title   = {{Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia}},
  journal = {Nature neuroscience},
  year    = {2020},
  doi     = {10.1038/s41593-020-0650-6},
  pmid    = {32514138},
  url     = {https://doi.org/10.1038/s41593-020-0650-6}
}

@article{mecca2018-29361745,
  author  = {Mecca, C. and Giambanco, I. and Donato, R. and Arcuri, C.},
  title   = {{Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms19010318},
  pmid    = {29361745},
  url     = {https://doi.org/10.3390/ijms19010318}
}

@article{vanacker2019-31159836,
  author  = {Van Acker, Z. P. and Bretou, M. and Annaert, W.},
  title   = {{Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0323-7},
  pmid    = {31159836},
  url     = {https://doi.org/10.1186/s13024-019-0323-7}
}

@article{klunemann2005-15883308,
  author  = {Klünemann, H. H. and Ridha, B. H. and Magy, L. and Wherrett, JR. and Hemelsoet, D. M. and Keen, R. W. and De Bleecker, J. L. and Rossor, M. N. and others},
  title   = {{The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000160304.00003.ca},
  pmid    = {15883308},
  url     = {https://doi.org/10.1212/01.wnl.0000160304.00003.ca}
}

@article{qin2021-33516818,
  author  = {Qin, Q. and Teng, Z. and Liu, C. and Li, Q. and Yin, Y. and Tang, Y.},
  title   = {{TREM2, microglia, and Alzheimer's disease}},
  journal = {Mechanisms of ageing and development},
  year    = {2021},
  doi     = {10.1016/j.mad.2021.111438},
  pmid    = {33516818},
  url     = {https://doi.org/10.1016/j.mad.2021.111438}
}

@article{feuerbach2017-28923481,
  author  = {Feuerbach, D. and Schindler, P. and Barske, C. and Joller, S. and Beng-Louka, E. and Worringer, K. A. and Kommineni, S. and Kaykas, A. and others},
  title   = {{ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157}},
  journal = {Neuroscience letters},
  year    = {2017},
  doi     = {10.1016/j.neulet.2017.09.034},
  pmid    = {28923481},
  url     = {https://doi.org/10.1016/j.neulet.2017.09.034}
}

@article{garciareitboeck2018-30157425,
  author  = {Garcia-Reitboeck, P. and Phillips, A. and Piers, T. M. and Villegas-Llerena, C. and Butler, M. and Mallach, A. and Rodrigues, C. and Arber, C. E. and others},
  title   = {{Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis}},
  journal = {Cell reports},
  year    = {2018},
  doi     = {10.1016/j.celrep.2018.07.094},
  pmid    = {30157425},
  url     = {https://doi.org/10.1016/j.celrep.2018.07.094}
}

@article{piers2020-31907987,
  author  = {Piers, T. M. and Cosker, K. and Mallach, A. and Johnson, G. T. and Guerreiro, R. and Hardy, J. and Pocock, J. M.},
  title   = {{A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2020},
  doi     = {10.1096/fj.201902447r},
  pmid    = {31907987},
  url     = {https://doi.org/10.1096/fj.201902447r}
}

@article{garciarevilla2022-35859075,
  author  = {García-Revilla, J. and Boza-Serrano, A. and Espinosa-Oliva, A. M. and Soto, M. S. and Deierborg, T. and Ruiz, R. and de Pablos, R. M. and Burguillos, M. A. and others},
  title   = {{Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration}},
  journal = {Cell death \& disease},
  year    = {2022},
  doi     = {10.1038/s41419-022-05058-3},
  pmid    = {35859075},
  url     = {https://doi.org/10.1038/s41419-022-05058-3}
}

@article{wang2022-36031601,
  author  = {Wang, Y. and Johnson, K. C. C. and Gatti-Mays, M. E. and Li, Z.},
  title   = {{Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy}},
  journal = {Journal of hematology \& oncology},
  year    = {2022},
  doi     = {10.1186/s13045-022-01335-y},
  pmid    = {36031601},
  url     = {https://doi.org/10.1186/s13045-022-01335-y}
}

@article{piollet2024-38974464,
  author  = {Piollet, M. and Porsch, F. and Rizzo, G. and Kapser, F. and Schulz, D. J. J. and Kiss, M. G. and Schlepckow, K. and Morenas-Rodriguez, E. and others},
  title   = {{TREM2 protects from atherosclerosis by limiting necrotic core formation}},
  journal = {Nature cardiovascular research},
  year    = {2024},
  doi     = {10.1038/s44161-024-00429-9},
  pmid    = {38974464},
  url     = {https://doi.org/10.1038/s44161-024-00429-9}
}

@article{fang2024-38617547,
  author  = {Fang, C. and Zhong, R. and Lu, S. and Yu, G. and Liu, Z. and Yan, C. and Gao, J. and Tang, Y. and others},
  title   = {{TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis}},
  journal = {International journal of biological sciences},
  year    = {2024},
  doi     = {10.7150/ijbs.91519},
  pmid    = {38617547},
  url     = {https://doi.org/10.7150/ijbs.91519}
}

@article{salih2019-32274467,
  author  = {Salih, D. A. and Bayram, S. and Guelfi, S. and Reynolds, R. H. and Shoai, M. and Ryten, M. and Brenton, J. W. and Zhang, D. and others},
  title   = {{Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk}},
  journal = {Brain communications},
  year    = {2019},
  doi     = {10.1093/braincomms/fcz022},
  pmid    = {32274467},
  url     = {https://doi.org/10.1093/braincomms/fcz022}
}

@article{wei2024-38042110,
  author  = {Wei, W. and Zhang, L. and Xin, W. and Pan, Y. and Tatenhorst, L. and Hao, Z. and Gerner, S. T. and Huber, S. and others},
  title   = {{TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2024},
  doi     = {10.1016/j.biopha.2023.115962},
  pmid    = {38042110},
  url     = {https://doi.org/10.1016/j.biopha.2023.115962}
}

@article{hou2023-36952346,
  author  = {Hou, J. and Zhou, Y. and Cai, Z. and Terekhova, M. and Swain, A. and Andhey, P. S. and Guimaraes, R. M. and Ulezko Antonova, A. and others},
  title   = {{Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination}},
  journal = {Cell reports},
  year    = {2023},
  doi     = {10.1016/j.celrep.2023.112293},
  pmid    = {36952346},
  url     = {https://doi.org/10.1016/j.celrep.2023.112293}
}

@article{sebastian2022-35967299,
  author  = {Sebastian, A. and Hum, N. R. and McCool, J. L. and Wilson, S. P. and Murugesh, D. K. and Martin, K. A. and Rios-Arce, N. D. and Amiri, B. and others},
  title   = {{Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.938075},
  pmid    = {35967299},
  url     = {https://doi.org/10.3389/fimmu.2022.938075}
}

@article{jiang2016-27067662,
  author  = {Jiang, T. and Tan, L. and Chen, Q. and Tan, M. S. and Zhou, J. S. and Zhu, X. C. and Lu, H. and Wang, H. F. and others},
  title   = {{A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.02.023},
  pmid    = {27067662},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.02.023}
}

@article{peng2025-39731912,
  author  = {Peng, X. and Sun, B. and Tang, C. and Shi, C. and Xie, X. and Wang, X. and Jiang, D. and Li, S. and others},
  title   = {{HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis}},
  journal = {Developmental cell},
  year    = {2025},
  doi     = {10.1016/j.devcel.2024.12.011},
  pmid    = {39731912},
  url     = {https://doi.org/10.1016/j.devcel.2024.12.011}
}

@article{brendel2017-28197095,
  author  = {Brendel, M. and Kleinberger, G. and Probst, F. and Jaworska, A. and Overhoff, F. and Blume, T. and Albert, N. L. and Carlsen, J. and others},
  title   = {{Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00008},
  pmid    = {28197095},
  url     = {https://doi.org/10.3389/fnagi.2017.00008}
}

@article{jairaman2022-35191835,
  author  = {Jairaman, A. and McQuade, A. and Granzotto, A. and Kang, Y. J. and Chadarevian, J. P. and Gandhi, S. and Parker, I. and Smith, I. and others},
  title   = {{TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia}},
  journal = {eLife},
  year    = {2022},
  doi     = {10.7554/elife.73021},
  pmid    = {35191835},
  url     = {https://doi.org/10.7554/elife.73021}
}

@article{liebold2023-36766683,
  author  = {Liebold, I. and Meyer, S. and Heine, M. and Kuhl, A. and Witt, J. and Eissing, L. and Fischer, A. W. and Koop, A. C. and others},
  title   = {{TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD}},
  journal = {Cells},
  year    = {2023},
  doi     = {10.3390/cells12030341},
  pmid    = {36766683},
  url     = {https://doi.org/10.3390/cells12030341}
}

@article{sharif2021-33627323,
  author  = {Sharif, O. and Brunner, J. S. and Korosec, A. and Martins, R. and Jais, A. and Snijder, B. and Vogel, A. and Caldera, M. and others},
  title   = {{Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages}},
  journal = {Diabetes},
  year    = {2021},
  doi     = {10.2337/db20-0572},
  pmid    = {33627323},
  url     = {https://doi.org/10.2337/db20-0572}
}

@article{kober2017-28432014,
  author  = {Kober, D. L. and Brett, T. J.},
  title   = {{TREM2-Ligand Interactions in Health and Disease}},
  journal = {Journal of molecular biology},
  year    = {2017},
  doi     = {10.1016/j.jmb.2017.04.004},
  pmid    = {28432014},
  url     = {https://doi.org/10.1016/j.jmb.2017.04.004}
}

@article{yin2017-28434692,
  author  = {Yin, Z. and Raj, D. and Saiepour, N. and Van Dam, D. and Brouwer, N. and Holtman, I. R. and Eggen, B. J. L. and Möller, T. and others},
  title   = {{Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.03.021},
  pmid    = {28434692},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.03.021}
}

@article{mcquade2019-30738892,
  author  = {McQuade, A. and Blurton-Jones, M.},
  title   = {{Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk}},
  journal = {Journal of molecular biology},
  year    = {2019},
  doi     = {10.1016/j.jmb.2019.01.045},
  pmid    = {30738892},
  url     = {https://doi.org/10.1016/j.jmb.2019.01.045}
}

@article{zhang2023-36635449,
  author  = {Zhang, K. and Wang, Y. and Chen, S. and Mao, J. and Jin, Y. and Ye, H. and Zhang, Y. and Liu, X. and others},
  title   = {{TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis}},
  journal = {Nature metabolism},
  year    = {2023},
  doi     = {10.1038/s42255-022-00715-5},
  pmid    = {36635449},
  url     = {https://doi.org/10.1038/s42255-022-00715-5}
}

@article{hickman2014-24355566,
  author  = {Hickman, S. E. and El Khoury, J.},
  title   = {{TREM2 and the neuroimmunology of Alzheimer's disease}},
  journal = {Biochemical pharmacology},
  year    = {2014},
  doi     = {10.1016/j.bcp.2013.11.021},
  pmid    = {24355566},
  url     = {https://doi.org/10.1016/j.bcp.2013.11.021}
}

@article{guner2020-32616437,
  author  = {Güner, G. and Lichtenthaler, S. F.},
  title   = {{The substrate repertoire of γ-secretase/presenilin}},
  journal = {Seminars in cell \& developmental biology},
  year    = {2020},
  doi     = {10.1016/j.semcdb.2020.05.019},
  pmid    = {32616437},
  url     = {https://doi.org/10.1016/j.semcdb.2020.05.019}
}

@article{xiang2016-27402340,
  author  = {Xiang, X. and Werner, G. and Bohrmann, B. and Liesz, A. and Mazaheri, F. and Capell, A. and Feederle, R. and Knuesel, I. and others},
  title   = {{TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201606370},
  pmid    = {27402340},
  url     = {https://doi.org/10.15252/emmm.201606370}
}

@article{jiang2016-26802771,
  author  = {Jiang, T. and Zhang, Y. D. and Chen, Q. and Gao, Q. and Zhu, X. C. and Zhou, J. S. and Shi, J. Q. and Lu, H. and others},
  title   = {{TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice}},
  journal = {Neuropharmacology},
  year    = {2016},
  doi     = {10.1016/j.neuropharm.2016.01.028},
  pmid    = {26802771},
  url     = {https://doi.org/10.1016/j.neuropharm.2016.01.028}
}

@article{wang2020-33065553,
  author  = {Wang, Y. and Lin, Y. and Wang, L. and Zhan, H. and Luo, X. and Zeng, Y. and Wu, W. and Zhang, X. and others},
  title   = {{TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice}},
  journal = {Aging},
  year    = {2020},
  doi     = {10.18632/aging.104104},
  pmid    = {33065553},
  url     = {https://doi.org/10.18632/aging.104104}
}

@article{liao2017-27922847,
  author  = {Liao, F. and Yoon, H. and Kim, J.},
  title   = {{Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease}},
  journal = {Current opinion in lipidology},
  year    = {2017},
  doi     = {10.1097/mol.0000000000000383},
  pmid    = {27922847},
  url     = {https://doi.org/10.1097/mol.0000000000000383}
}

@article{savage2015-25904803,
  author  = {Savage, J. C. and Jay, T. and Goduni, E. and Quigley, C. and Mariani, M. M. and Malm, T. and Ransohoff, R. M. and Lamb, B. T. and others},
  title   = {{Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.4586-14.2015},
  pmid    = {25904803},
  url     = {https://doi.org/10.1523/jneurosci.4586-14.2015}
}

@article{kobayashi2016-27798193,
  author  = {Kobayashi, M. and Konishi, H. and Sayo, A. and Takai, T. and Kiyama, H.},
  title   = {{TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.1238-16.2016},
  pmid    = {27798193},
  url     = {https://doi.org/10.1523/jneurosci.1238-16.2016}
}

@article{zhu2022-36056435,
  author  = {Zhu, B. and Liu, Y. and Hwang, S. and Archuleta, K. and Huang, H. and Campos, A. and Murad, R. and Piña-Crespo, J. and others},
  title   = {{Trem2 deletion enhances tau dispersion and pathology through microglia exosomes}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00562-8},
  pmid    = {36056435},
  url     = {https://doi.org/10.1186/s13024-022-00562-8}
}

@article{yan2022-36463233,
  author  = {Yan, J. and Zhang, Y. and Wang, L. and Li, Z. and Tang, S. and Wang, Y. and Gu, N. and Sun, X. and others},
  title   = {{TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02651-3},
  pmid    = {36463233},
  url     = {https://doi.org/10.1186/s12974-022-02651-3}
}

@article{cohn2021-34925024,
  author  = {Cohn, W. and Melnik, M. and Huang, C. and Teter, B. and Chandra, S. and Zhu, C. and McIntire, L. B. and John, V. and others},
  title   = {{Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.766082},
  pmid    = {34925024},
  url     = {https://doi.org/10.3389/fphar.2021.766082}
}

@article{zheng2016-27143430,
  author  = {Zheng, H. and Liu, C. C. and Atagi, Y. and Chen, X. F. and Jia, L. and Yang, L. and He, W. and Zhang, X. and others},
  title   = {{Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.03.004},
  pmid    = {27143430},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.03.004}
}

@article{chen2023-37563723,
  author  = {Chen, J. and Zhu, T. and Jiang, G. and Zeng, Q. and Li, Z. and Huang, X.},
  title   = {{Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer}},
  journal = {Molecular cancer},
  year    = {2023},
  doi     = {10.1186/s12943-023-01830-x},
  pmid    = {37563723},
  url     = {https://doi.org/10.1186/s12943-023-01830-x}
}

@article{linnartzgerlach2019-30548312,
  author  = {Linnartz-Gerlach, B. and Bodea, L. G. and Klaus, C. and Ginolhac, A. and Halder, R. and Sinkkonen, L. and Walter, J. and Colonna, M. and others},
  title   = {{TREM2 triggers microglial density and age-related neuronal loss}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23563},
  pmid    = {30548312},
  url     = {https://doi.org/10.1002/glia.23563}
}

@article{jiang2015-26364736,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhou, J. S. and Cao, L. and Tan, M. S. and Wang, H. F. and Chen, Q. and others},
  title   = {{Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2015.08.019},
  pmid    = {26364736},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.08.019}
}

@article{suarezcalvet2018-30482868,
  author  = {Suárez-Calvet, M. and Capell, A. and MÁ, Araque Caballero and Morenas-Rodríguez, E. and Fellerer, K. and Franzmeier, N. and Kleinberger, G. and Eren, E. and others},
  title   = {{CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline}},
  journal = {EMBO molecular medicine},
  year    = {2018},
  doi     = {10.15252/emmm.201809712},
  pmid    = {30482868},
  url     = {https://doi.org/10.15252/emmm.201809712}
}

@article{benitez2021-34266459,
  author  = {Benitez, D. P. and Jiang, S. and Wood, J. and Wang, R. and Hall, C. M. and Peerboom, C. and Wong, N. and Stringer, K. M. and others},
  title   = {{Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00457-0},
  pmid    = {34266459},
  url     = {https://doi.org/10.1186/s13024-021-00457-0}
}

@article{zhong2024-38788719,
  author  = {Zhong, J. and Xing, X. and Gao, Y. and Pei, L. and Lu, C. and Sun, H. and Lai, Y. and Du, K. and others},
  title   = {{Distinct roles of TREM2 in central nervous system cancers and peripheral cancers}},
  journal = {Cancer cell},
  year    = {2024},
  doi     = {10.1016/j.ccell.2024.05.001},
  pmid    = {38788719},
  url     = {https://doi.org/10.1016/j.ccell.2024.05.001}
}

@article{takahashi2017-28070672,
  author  = {Takahashi, H. and Klein, Z. A. and Bhagat, S. M. and Kaufman, A. C. and Kostylev, M. A. and Ikezu, T. and Strittmatter, S. M. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network}},
  journal = {Acta neuropathologica},
  year    = {2017},
  doi     = {10.1007/s00401-017-1668-z},
  pmid    = {28070672},
  url     = {https://doi.org/10.1007/s00401-017-1668-z}
}

@article{endoumeda2022-35477277,
  author  = {Endo-Umeda, K. and Kim, E. and Thomas, D. G. and Liu, W. and Dou, H. and Yalcinkaya, M. and Abramowicz, S. and Xiao, T. and others},
  title   = {{Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2022},
  doi     = {10.1161/atvbaha.122.317583},
  pmid    = {35477277},
  url     = {https://doi.org/10.1161/atvbaha.122.317583}
}

@article{liu2025-40712453,
  author  = {Liu, T. and Kong, X. and Qiao, J. and Wei, J.},
  title   = {{Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovations}},
  journal = {Redox biology},
  year    = {2025},
  doi     = {10.1016/j.redox.2025.103787},
  pmid    = {40712453},
  url     = {https://doi.org/10.1016/j.redox.2025.103787}
}

@article{zhou2022-35359989,
  author  = {Zhou, L. and Wang, M. and Guo, H. and Hou, J. and Zhang, Y. and Li, M. and Wu, X. and Chen, X. and others},
  title   = {{Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.848367},
  pmid    = {35359989},
  url     = {https://doi.org/10.3389/fimmu.2022.848367}
}

@article{hauremirande2019-30283032,
  author  = {Haure-Mirande, J. V. and Wang, M. and Audrain, M. and Fanutza, T. and Kim, S. H. and Heja, S. and Readhead, B. and Dudley, J. T. and others},
  title   = {{Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden}},
  journal = {Molecular psychiatry},
  year    = {2019},
  doi     = {10.1038/s41380-018-0255-6},
  pmid    = {30283032},
  url     = {https://doi.org/10.1038/s41380-018-0255-6}
}

@article{audrain2019-30283031,
  author  = {Audrain, M. and Haure-Mirande, J. V. and Wang, M. and Kim, S. H. and Fanutza, T. and Chakrabarty, P. and Fraser, P. and St George-Hyslop, P. H. and others},
  title   = {{Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau}},
  journal = {Molecular psychiatry},
  year    = {2019},
  doi     = {10.1038/s41380-018-0258-3},
  pmid    = {30283031},
  url     = {https://doi.org/10.1038/s41380-018-0258-3}
}

@article{greve2023-35348636,
  author  = {Greve, H. J. and Dunbar, A. L. and Lombo, C. G. and Ahmed, C. and Thang, M. and Messenger, E. J. and Mumaw, C. L. and Johnson, J. A. and others},
  title   = {{The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awac113},
  pmid    = {35348636},
  url     = {https://doi.org/10.1093/brain/awac113}
}

@article{banerjee2020-32176643,
  author  = {Banerjee, G. and Ambler, G. and Keshavan, A. and Paterson, R. W. and Foiani, M. S. and Toombs, J. and Heslegrave, A. and Dickson, J. C. and others},
  title   = {{Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-191254},
  pmid    = {32176643},
  url     = {https://doi.org/10.3233/jad-191254}
}

@article{fahrenhold2018-28987033,
  author  = {Fahrenhold, M. and Rakic, S. and Classey, J. and Brayne, C. and Ince, P. G. and Nicoll, J. A. R. and Boche, D. and MRC-CFAS},
  title   = {{TREM2 expression in the human brain: a marker of monocyte recruitment?}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2018},
  doi     = {10.1111/bpa.12564},
  pmid    = {28987033},
  url     = {https://doi.org/10.1111/bpa.12564}
}

@article{diluccia2024-38758808,
  author  = {Di Luccia, B. and Molgora, M. and Khantakova, D. and Jaeger, N. and Chang, H. W. and Czepielewski, R. S. and Helmink, B. A. and Onufer, E. J. and others},
  title   = {{TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy}},
  journal = {Science immunology},
  year    = {2024},
  doi     = {10.1126/sciimmunol.adi5374},
  pmid    = {38758808},
  url     = {https://doi.org/10.1126/sciimmunol.adi5374}
}

@article{rakina2024-38571605,
  author  = {Rakina, M. and Larionova, I. and Kzhyshkowska, J.},
  title   = {{Macrophage diversity in human cancers: New insight provided by single-cell resolution and spatial context}},
  journal = {Heliyon},
  year    = {2024},
  doi     = {10.1016/j.heliyon.2024.e28332},
  pmid    = {38571605},
  url     = {https://doi.org/10.1016/j.heliyon.2024.e28332}
}

@article{henn2021-34851663,
  author  = {Henn, D. and Chen, K. and Fehlmann, T. and Trotsyuk, A. A. and Sivaraj, D. and Maan, Z. N. and Bonham, C. A. and Barrera, J. A. and others},
  title   = {{Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2+ macrophages}},
  journal = {Science advances},
  year    = {2021},
  doi     = {10.1126/sciadv.abi4528},
  pmid    = {34851663},
  url     = {https://doi.org/10.1126/sciadv.abi4528}
}

@article{nwadiugwu2023-37106802,
  author  = {Nwadiugwu, M. and Shen, H. and Deng, H. W.},
  title   = {{Potential Molecular Mechanisms of Alzheimer's Disease from Genetic Studies}},
  journal = {Biology},
  year    = {2023},
  doi     = {10.3390/biology12040602},
  pmid    = {37106802},
  url     = {https://doi.org/10.3390/biology12040602}
}

@article{ndiaye2009-19171755,
  author  = {N’Diaye, Elsa-Noah and Branda, Catherine and Branda, Steven S. and Nevarez, Lisette and Colonna, Marco and Lowell, Clifford A. and Hamerman, Jessica A. and Seaman, William E.},
  title   = {{TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria}},
  journal = {The Journal of Cell Biology},
  year    = {2009},
  doi     = {10.1083/jcb.200808080},
  pmid    = {19171755},
  url     = {https://doi.org/10.1083/jcb.200808080}
}

@article{shi2022-36408515,
  author  = {Shi, Xiaolei and Zhong, Xiaomei and Zhou, Huarong and Zhou, Nan and Hu, Yachun and Ning, Yuping and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum}},
  journal = {Frontiers in neurology},
  year    = {2022},
  doi     = {10.3389/fneur.2022.961842},
  pmid    = {36408515},
  url     = {https://doi.org/10.3389/fneur.2022.961842}
}

@article{kim2022-36112222,
  author  = {Kim, Boram and Suh, EunRan and Nguyen, Aivi T and Prokop, Stefan and Mikytuck, Bailey and Olatunji, Olamide A and Robinson, John L and Grossman, Murray and others},
  title   = {{TREM2 risk variants are associated with atypical Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2022},
  doi     = {10.1007/s00401-022-02495-4},
  pmid    = {36112222},
  url     = {https://doi.org/10.1007/s00401-022-02495-4}
}

@article{berdynski2022-36031890,
  author  = {Berdyński, Mariusz and Ludwiczak, Jan and Barczak, Anna and Barcikowska-Kotowicz, Maria and Kuźma-Kozakiewicz, Magdalena and Dunin-Horkawicz, Stanisław and Żekanowski, Cezary and Borzemska, Beata},
  title   = {{TREM2 Gene Compound Heterozygosity in Neurodegenerative Disorders}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220210},
  pmid    = {36031890},
  url     = {https://doi.org/10.3233/jad-220210}
}

@article{feiten2026-41580393,
  author  = {Feiten, Astrid F and Dahm, Kilian and Schlepckow, Kai and van Lengerich, Bettina and Suh, Jung H and Reifschneider, Anika and Wefers, Benedikt and Bartos, Laura M and others},
  title   = {{TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68706-8},
  pmid    = {41580393},
  url     = {https://doi.org/10.1038/s41467-026-68706-8}
}

@article{abdulkhaliq2026-41792456,
  author  = {Abdulkhaliq, Altaf A and Alasiri, Glowi and Kim, Bonglee and Khan, Johra and Ajoolabady, Amir and Yousof, Shimaa Mohammad and Ren, Jun and Tuomilehto, Jaakko and others},
  title   = {{TREM2 in neurodegeneration and diseases}},
  journal = {Molecular psychiatry},
  year    = {2026},
  doi     = {10.1038/s41380-026-03505-7},
  pmid    = {41792456},
  url     = {https://doi.org/10.1038/s41380-026-03505-7}
}

@article{seno2009-19109436,
  author  = {Seno, H. and Miyoshi, H. and Brown, S. L. and Geske, M. J. and Colonna, M. and Stappenbeck, T. S.},
  title   = {{Efficient colonic mucosal wound repair requires Trem2 signaling}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0803343106},
  pmid    = {19109436},
  url     = {https://doi.org/10.1073/pnas.0803343106}
}

@article{gui2022-35498045,
  author  = {Gui, Y. and Zheng, H. and Cao, R. Y.},
  title   = {{Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms}},
  journal = {Frontiers in cardiovascular medicine},
  year    = {2022},
  doi     = {10.3389/fcvm.2022.845942},
  pmid    = {35498045},
  url     = {https://doi.org/10.3389/fcvm.2022.845942}
}

@article{loving2020-32411016,
  author  = {Loving, B. A. and Bruce, K. D.},
  title   = {{Lipid and Lipoprotein Metabolism in Microglia}},
  journal = {Frontiers in physiology},
  year    = {2020},
  doi     = {10.3389/fphys.2020.00393},
  pmid    = {32411016},
  url     = {https://doi.org/10.3389/fphys.2020.00393}
}

@article{brownjohn2018-29606617,
  author  = {Brownjohn, P. W. and Smith, J. and Solanki, R. and Lohmann, E. and Houlden, H. and Hardy, J. and Dietmann, S. and Livesey, F. J.},
  title   = {{Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia}},
  journal = {Stem cell reports},
  year    = {2018},
  doi     = {10.1016/j.stemcr.2018.03.003},
  pmid    = {29606617},
  url     = {https://doi.org/10.1016/j.stemcr.2018.03.003}
}

@article{huttenrauch2018-30340518,
  author  = {Hüttenrauch, M. and Ogorek, I. and Klafki, H. and Otto, M. and Stadelmann, C. and Weggen, S. and Wiltfang, J. and Wirths, O.},
  title   = {{Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia}},
  journal = {Acta neuropathologica communications},
  year    = {2018},
  doi     = {10.1186/s40478-018-0612-3},
  pmid    = {30340518},
  url     = {https://doi.org/10.1186/s40478-018-0612-3}
}

@article{song2019-31363137,
  author  = {Song, L. and Yuan, X. and Jones, Z. and Vied, C. and Miao, Y. and Marzano, M. and Hua, T. and Sang, Q. A. and others},
  title   = {{Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-47444-6},
  pmid    = {31363137},
  url     = {https://doi.org/10.1038/s41598-019-47444-6}
}

@article{liu2022-35712121,
  author  = {Liu, Z. and Gao, Z. and Li, B. and Li, J. and Ou, Y. and Yu, X. and Zhang, Z. and Liu, S. and others},
  title   = {{Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression}},
  journal = {Oncoimmunology},
  year    = {2022},
  doi     = {10.1080/2162402x.2022.2085432},
  pmid    = {35712121},
  url     = {https://doi.org/10.1080/2162402x.2022.2085432}
}

@article{chouraki2014-25311924,
  author  = {Chouraki, V. and Seshadri, S.},
  title   = {{Genetics of Alzheimer's disease}},
  journal = {Advances in genetics},
  year    = {2014},
  doi     = {10.1016/b978-0-12-800149-3.00005-6},
  pmid    = {25311924},
  url     = {https://doi.org/10.1016/b978-0-12-800149-3.00005-6}
}

@article{malik2015-26438529,
  author  = {Malik, M. and Parikh, I. and Vasquez, J. B. and Smith, C. and Tai, L. and Bu, G. and LaDu, M. J. and Fardo, D. W. and others},
  title   = {{Genetics ignite focus on microglial inflammation in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0048-1},
  pmid    = {26438529},
  url     = {https://doi.org/10.1186/s13024-015-0048-1}
}

@article{lee2020-31800167,
  author  = {Lee, J. and Kim, D. E. and Griffin, P. and Sheehan, P. W. and Kim, D. H. and Musiek, E. S. and Yoon, S. Y.},
  title   = {{Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease}},
  journal = {Aging cell},
  year    = {2020},
  doi     = {10.1111/acel.13078},
  pmid    = {31800167},
  url     = {https://doi.org/10.1111/acel.13078}
}

@article{nizami2019-30740661,
  author  = {Nizami, S. and Hall-Roberts, H. and Warrier, S. and Cowley, S. A. and Di Daniel, E.},
  title   = {{Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets}},
  journal = {British journal of pharmacology},
  year    = {2019},
  doi     = {10.1111/bph.14618},
  pmid    = {30740661},
  url     = {https://doi.org/10.1111/bph.14618}
}

@article{shi2022-35672148,
  author  = {Shi, Q. and Chang, C. and Saliba, A. and Bhat, M. A.},
  title   = {{Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2022},
  doi     = {10.1523/jneurosci.2427-21.2022},
  pmid    = {35672148},
  url     = {https://doi.org/10.1523/jneurosci.2427-21.2022}
}

@article{sieber2013-23301011,
  author  = {Sieber, M. W. and Jaenisch, N. and Brehm, M. and Guenther, M. and Linnartz-Gerlach, B. and Neumann, H. and Witte, O. W. and Frahm, C.},
  title   = {{Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0052982},
  pmid    = {23301011},
  url     = {https://doi.org/10.1371/journal.pone.0052982}
}

@article{rangaraju2018-29552013,
  author  = {Rangaraju, S. and Raza, S. A. and Li, N. X. and Betarbet, R. and Dammer, E. B. and Duong, D. and Lah, J. J. and Seyfried, N. T. and others},
  title   = {{Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects}},
  journal = {Frontiers in immunology},
  year    = {2018},
  doi     = {10.3389/fimmu.2018.00405},
  pmid    = {29552013},
  url     = {https://doi.org/10.3389/fimmu.2018.00405}
}

@article{kemp2021-33782087,
  author  = {Kemp, S. B. and Steele, N. G. and Carpenter, E. S. and Donahue, K. L. and Bushnell, G. G. and Morris, A. H. and The, S. and Orbach, S. M. and others},
  title   = {{Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages}},
  journal = {Life science alliance},
  year    = {2021},
  doi     = {10.26508/lsa.202000935},
  pmid    = {33782087},
  url     = {https://doi.org/10.26508/lsa.202000935}
}

@article{reiner2012-22939635,
  author  = {Reiner, A. P. and Beleza, S. and Franceschini, N. and Auer, P. L. and Robinson, J. G. and Kooperberg, C. and Peters, U. and Tang, H.},
  title   = {{Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women}},
  journal = {American journal of human genetics},
  year    = {2012},
  doi     = {10.1016/j.ajhg.2012.07.023},
  pmid    = {22939635},
  url     = {https://doi.org/10.1016/j.ajhg.2012.07.023}
}

@article{huggins2021-34389631,
  author  = {Huggins, D. N. and LaRue, R. S. and Wang, Y. and Knutson, T. P. and Xu, Y. and Williams, J. W. and Schwertfeger, K. L.},
  title   = {{Characterizing Macrophage Diversity in Metastasis-Bearing Lungs Reveals a Lipid-Associated Macrophage Subset}},
  journal = {Cancer research},
  year    = {2021},
  doi     = {10.1158/0008-5472.can-21-0101},
  pmid    = {34389631},
  url     = {https://doi.org/10.1158/0008-5472.can-21-0101}
}

@article{perea2020-33066368,
  author  = {Perea, JR. and Bolós, M. and Avila, J.},
  title   = {{Microglia in Alzheimer's Disease in the Context of Tau Pathology}},
  journal = {Biomolecules},
  year    = {2020},
  doi     = {10.3390/biom10101439},
  pmid    = {33066368},
  url     = {https://doi.org/10.3390/biom10101439}
}

@article{graham2016-26888450,
  author  = {Graham, L. C. and Harder, J. M. and Soto, I. and de Vries, W. N. and John, S. W. and Howell, G. R.},
  title   = {{Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2016},
  doi     = {10.1038/srep21568},
  pmid    = {26888450},
  url     = {https://doi.org/10.1038/srep21568}
}

@article{fassler2021-33422057,
  author  = {Fassler, M. and Rappaport, M. S. and Cuño, C. B. and George, J.},
  title   = {{Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-020-01980-5},
  pmid    = {33422057},
  url     = {https://doi.org/10.1186/s12974-020-01980-5}
}

@article{stephen2019-31113487,
  author  = {Stephen, T. L. and Cacciottolo, M. and Balu, D. and Morgan, T. E. and LaDu, M. J. and Finch, C. E. and Pike, C. J.},
  title   = {{APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice}},
  journal = {Acta neuropathologica communications},
  year    = {2019},
  doi     = {10.1186/s40478-019-0729-z},
  pmid    = {31113487},
  url     = {https://doi.org/10.1186/s40478-019-0729-z}
}

@article{takalo2020-32917267,
  author  = {Takalo, M. and Wittrahm, R. and Wefers, B. and Parhizkar, S. and Jokivarsi, K. and Kuulasmaa, T. and Mäkinen, P. and Martiskainen, H. and others},
  title   = {{The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00402-7},
  pmid    = {32917267},
  url     = {https://doi.org/10.1186/s13024-020-00402-7}
}

@article{boschqueralt2021-33619376,
  author  = {Bosch-Queralt, M. and Cantuti-Castelvetri, L. and Damkou, A. and Schifferer, M. and Schlepckow, K. and Alexopoulos, I. and Lütjohann, D. and Klose, C. and others},
  title   = {{Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination}},
  journal = {Nature metabolism},
  year    = {2021},
  doi     = {10.1038/s42255-021-00341-7},
  pmid    = {33619376},
  url     = {https://doi.org/10.1038/s42255-021-00341-7}
}

@article{soares2021-34831271,
  author  = {Soares, L. C. and Al-Dalahmah, O. and Hillis, J. and Young, C. C. and Asbed, I. and Sakaguchi, M. and O'Neill, E. and Szele, F. G.},
  title   = {{Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10113047},
  pmid    = {34831271},
  url     = {https://doi.org/10.3390/cells10113047}
}

@article{terzioglu2023-38017562,
  author  = {Terzioglu, G. and Young-Pearse, T. L.},
  title   = {{Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00674-9},
  pmid    = {38017562},
  url     = {https://doi.org/10.1186/s13024-023-00674-9}
}

@article{li2022-35741054,
  author  = {Li, T. and Lu, L. and Pember, E. and Li, X. and Zhang, B. and Zhu, Z.},
  title   = {{New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer's Disease and Its Potential for Therapeutic Intervention}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11121925},
  pmid    = {35741054},
  url     = {https://doi.org/10.3390/cells11121925}
}

@article{patterson2024-38695172,
  author  = {Patterson, M. T. and Xu, Y. and Hillman, H. and Osinski, V. and Schrank, P. R. and Kennedy, A. E. and Barrow, F. and Zhu, A. and others},
  title   = {{Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2024},
  doi     = {10.1161/atvbaha.124.320797},
  pmid    = {38695172},
  url     = {https://doi.org/10.1161/atvbaha.124.320797}
}

@article{thomas2022-36376530,
  author  = {Thomas, A. L. and Lehn, M. A. and Janssen, E. M. and Hildeman, D. A. and Chougnet, C. A.},
  title   = {{Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease}},
  journal = {Scientific reports},
  year    = {2022},
  doi     = {10.1038/s41598-022-21920-y},
  pmid    = {36376530},
  url     = {https://doi.org/10.1038/s41598-022-21920-y}
}

@article{schoch2021-34187891,
  author  = {Schoch, K. M. and Ezerskiy, L. A. and Morhaus, M. M. and Bannon, R. N. and Sauerbeck, A. D. and Shabsovich, M. and Jafar-Nejad, P. and Rigo, F. and others},
  title   = {{Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2100356118},
  pmid    = {34187891},
  url     = {https://doi.org/10.1073/pnas.2100356118}
}

@article{macdonald2021-34143756,
  author  = {MacDonald, L. and Alivernini, S. and Tolusso, B. and Elmesmari, A. and Somma, D. and Perniola, S. and Paglionico, A. and Petricca, L. and others},
  title   = {{COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes}},
  journal = {JCI insight},
  year    = {2021},
  doi     = {10.1172/jci.insight.147413},
  pmid    = {34143756},
  url     = {https://doi.org/10.1172/jci.insight.147413}
}

@article{zhou2024-38478630,
  author  = {Zhou, L. and Qiu, X. and Meng, Z. and Liu, T. and Chen, Z. and Zhang, P. and Kuang, H. and Pan, T. and others},
  title   = {{Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adk1866},
  pmid    = {38478630},
  url     = {https://doi.org/10.1126/scitranslmed.adk1866}
}

@article{cui2024-38849370,
  author  = {Cui, Y. and Chen, C. and Tang, Z. and Yuan, W. and Yue, K. and Cui, P. and Qiu, X. and Zhang, H. and others},
  title   = {{TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice}},
  journal = {Cell death \& disease},
  year    = {2024},
  doi     = {10.1038/s41419-024-06756-w},
  pmid    = {38849370},
  url     = {https://doi.org/10.1038/s41419-024-06756-w}
}

@article{lu2022-36411661,
  author  = {Lu, Y. P. and Wu, H. W. and Zhu, T. and Li, X. T. and Zuo, J. and Hasan, A. A. and Reichetzeder, C. and Delic, D. and others},
  title   = {{Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2022},
  doi     = {10.1016/j.biopha.2022.113947},
  pmid    = {36411661},
  url     = {https://doi.org/10.1016/j.biopha.2022.113947}
}

@article{gockley2021-33947463,
  author  = {Gockley, J. and Montgomery, K. S. and Poehlman, W. L. and Wiley, J. C. and Liu, Y. and Gerasimov, E. and Greenwood, A. K. and Sieberts, S. K. and others},
  title   = {{Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease}},
  journal = {Genome medicine},
  year    = {2021},
  doi     = {10.1186/s13073-021-00890-2},
  pmid    = {33947463},
  url     = {https://doi.org/10.1186/s13073-021-00890-2}
}

@article{ren2020-32579116,
  author  = {Ren, S. and Yao, W. and Tambini, M. D. and Yin, T. and Norris, K. A. and D'Adamio, L.},
  title   = {{Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels}},
  journal = {eLife},
  year    = {2020},
  doi     = {10.7554/elife.57513},
  pmid    = {32579116},
  url     = {https://doi.org/10.7554/elife.57513}
}

@article{roveta2024-39596011,
  author  = {Roveta, F. and Bonino, L. and Piella, E. M. and Rainero, I. and Rubino, E.},
  title   = {{Neuroinflammatory Biomarkers in Alzheimer's Disease: From Pathophysiology to Clinical Implications}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms252211941},
  pmid    = {39596011},
  url     = {https://doi.org/10.3390/ijms252211941}
}

@article{audrain2021-33314529,
  author  = {Audrain, M. and Haure-Mirande, J. V. and Mleczko, J. and Wang, M. and Griffin, J. K. and St George-Hyslop, P. H. and Fraser, P. and Zhang, B. and others},
  title   = {{Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12256},
  pmid    = {33314529},
  url     = {https://doi.org/10.1002/alz.12256}
}

@article{kamila2025-40510290,
  author  = {Kamila, P. and Kar, K. and Chowdhury, S. and Chakraborty, P. and Dutta, R. and Singh S, A. and Prajapati, B. G.},
  title   = {{Effect of neuroinflammation on the progression of Alzheimer's disease and its significant ramifications for novel anti-inflammatory treatments}},
  journal = {IBRO neuroscience reports},
  year    = {2025},
  doi     = {10.1016/j.ibneur.2025.05.005},
  pmid    = {40510290},
  url     = {https://doi.org/10.1016/j.ibneur.2025.05.005}
}

@article{kang2018-29040522,
  author  = {Kang, S. S. and Kurti, A. and Baker, K. E. and Liu, C. C. and Colonna, M. and Ulrich, J. D. and Holtzman, D. M. and Bu, G. and others},
  title   = {{Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal}},
  journal = {Human molecular genetics},
  year    = {2018},
  doi     = {10.1093/hmg/ddx366},
  pmid    = {29040522},
  url     = {https://doi.org/10.1093/hmg/ddx366}
}

@article{wood2022-36417868,
  author  = {Wood, J. I. and Wong, E. and Joghee, R. and Balbaa, A. and Vitanova, K. S. and Stringer, K. M. and Vanshoiack, A. and Phelan, S. J. and others},
  title   = {{Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology}},
  journal = {Cell reports},
  year    = {2022},
  doi     = {10.1016/j.celrep.2022.111686},
  pmid    = {36417868},
  url     = {https://doi.org/10.1016/j.celrep.2022.111686}
}

@article{rauchmann2020-31958095,
  author  = {Rauchmann, B. S. and Sadlon, A. and Perneczky, R. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-191120},
  pmid    = {31958095},
  url     = {https://doi.org/10.3233/jad-191120}
}

@article{villegasllerena2016-26517285,
  author  = {Villegas-Llerena, C. and Phillips, A. and Garcia-Reitboeck, P. and Hardy, J. and Pocock, J. M.},
  title   = {{Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease}},
  journal = {Current opinion in neurobiology},
  year    = {2016},
  doi     = {10.1016/j.conb.2015.10.004},
  pmid    = {26517285},
  url     = {https://doi.org/10.1016/j.conb.2015.10.004}
}

@article{song2019-31033233,
  author  = {Song, Q. and Hawkins, G. A. and Wudel, L. and Chou, P. C. and Forbes, E. and Pullikuth, A. K. and Liu, L. and Jin, G. and others},
  title   = {{Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq}},
  journal = {Cancer medicine},
  year    = {2019},
  doi     = {10.1002/cam4.2113},
  pmid    = {31033233},
  url     = {https://doi.org/10.1002/cam4.2113}
}

@article{sudom2018-29794134,
  author  = {Sudom, A. and Talreja, S. and Danao, J. and Bragg, E. and Kegel, R. and Min, X. and Richardson, J. and Zhang, Z. and others},
  title   = {{Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2}},
  journal = {The Journal of biological chemistry},
  year    = {2018},
  doi     = {10.1074/jbc.ra118.002352},
  pmid    = {29794134},
  url     = {https://doi.org/10.1074/jbc.ra118.002352}
}

@article{wu2017-28592261,
  author  = {Wu, R. and Li, X. and Xu, P. and Huang, L. and Cheng, J. and Huang, X. and Jiang, J. and Wu, L. J. and others},
  title   = {{TREM2 protects against cerebral ischemia/reperfusion injury}},
  journal = {Molecular brain},
  year    = {2017},
  doi     = {10.1186/s13041-017-0296-9},
  pmid    = {28592261},
  url     = {https://doi.org/10.1186/s13041-017-0296-9}
}

@article{allcock2003-12645956,
  author  = {Allcock, R. J. and Barrow, A. D. and Forbes, S. and Beck, S. and Trowsdale, J.},
  title   = {{The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44}},
  journal = {European journal of immunology},
  year    = {2003},
  doi     = {10.1002/immu.200310033},
  pmid    = {12645956},
  url     = {https://doi.org/10.1002/immu.200310033}
}

@article{bagyinszky2014-24729694,
  author  = {Bagyinszky, E. and Youn, Y. C. and An, S. S. and Kim, S.},
  title   = {{The genetics of Alzheimer's disease}},
  journal = {Clinical interventions in aging},
  year    = {2014},
  doi     = {10.2147/cia.s51571},
  pmid    = {24729694},
  url     = {https://doi.org/10.2147/cia.s51571}
}

@article{stefano2009-19457124,
  author  = {Stefano, L. and Racchetti, G. and Bianco, F. and Passini, N. and Gupta, R. S. and Panina Bordignon, P. and Meldolesi, J.},
  title   = {{The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06130.x},
  pmid    = {19457124},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.06130.x}
}

@article{condello2018-29169609,
  author  = {Condello, C. and Yuan, P. and Grutzendler, J.},
  title   = {{Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging}},
  journal = {Biological psychiatry},
  year    = {2018},
  doi     = {10.1016/j.biopsych.2017.10.007},
  pmid    = {29169609},
  url     = {https://doi.org/10.1016/j.biopsych.2017.10.007}
}

@article{kim2017-28894284,
  author  = {Kim, S. M. and Mun, B. R. and Lee, S. J. and Joh, Y. and Lee, H. Y. and Ji, K. Y. and Choi, H. R. and Lee, E. H. and others},
  title   = {{TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-11634-x},
  pmid    = {28894284},
  url     = {https://doi.org/10.1038/s41598-017-11634-x}
}

@article{puigdellivol2020-32581723,
  author  = {Puigdellívol, M. and Allendorf, D. H. and Brown, G. C.},
  title   = {{Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2020},
  doi     = {10.3389/fncel.2020.00162},
  pmid    = {32581723},
  url     = {https://doi.org/10.3389/fncel.2020.00162}
}

@article{yao2019-31649511,
  author  = {Yao, H. and Coppola, K. and Schweig, J. E. and Crawford, F. and Mullan, M. and Paris, D.},
  title   = {{Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2019},
  doi     = {10.3389/fncel.2019.00457},
  pmid    = {31649511},
  url     = {https://doi.org/10.3389/fncel.2019.00457}
}

@article{zhang2022-35278107,
  author  = {Zhang, H. and Liu, Z. and Wen, H. and Guo, Y. and Xu, F. and Zhu, Q. and Yuan, W. and Luo, R. and others},
  title   = {{Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer}},
  journal = {Cancer immunology, immunotherapy : CII},
  year    = {2022},
  doi     = {10.1007/s00262-022-03173-w},
  pmid    = {35278107},
  url     = {https://doi.org/10.1007/s00262-022-03173-w}
}

@article{zhang2022-35123512,
  author  = {Zhang, S. S. and Zhu, L. and Peng, Y. and Zhang, L. and Chao, F. L. and Jiang, L. and Xiao, Q. and Liang, X. and others},
  title   = {{Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02401-5},
  pmid    = {35123512},
  url     = {https://doi.org/10.1186/s12974-022-02401-5}
}

@article{li2023-37517293,
  author  = {Li, Y. and Xu, H. and Wang, H. and Yang, K. and Luan, J. and Wang, S.},
  title   = {{TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2023},
  doi     = {10.1016/j.biopha.2023.115218},
  pmid    = {37517293},
  url     = {https://doi.org/10.1016/j.biopha.2023.115218}
}

@article{bekris2018-29685286,
  author  = {Bekris, L. M. and Khrestian, M. and Dyne, E. and Shao, Y. and Pillai, J. A. and Rao, S. M. and Bemiller, S. M. and Lamb, B. and others},
  title   = {{Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease}},
  journal = {Journal of neuroimmunology},
  year    = {2018},
  doi     = {10.1016/j.jneuroim.2018.03.003},
  pmid    = {29685286},
  url     = {https://doi.org/10.1016/j.jneuroim.2018.03.003}
}

@article{chaney2019-30339715,
  author  = {Chaney, A. and Williams, SR. and Boutin, H.},
  title   = {{In vivo molecular imaging of neuroinflammation in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2019},
  doi     = {10.1111/jnc.14615},
  pmid    = {30339715},
  url     = {https://doi.org/10.1111/jnc.14615}
}

@article{wang2024-38942796,
  author  = {Wang, Y. and Chen, W. and Qiao, S. and Zou, H. and Yu, X. J. and Yang, Y. and Li, Z. and Wang, J. and others},
  title   = {{Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma}},
  journal = {Cellular \& molecular immunology},
  year    = {2024},
  doi     = {10.1038/s41423-024-01199-x},
  pmid    = {38942796},
  url     = {https://doi.org/10.1038/s41423-024-01199-x}
}

@article{nam2017-28655926,
  author  = {Nam, K. N. and Mounier, A. and Wolfe, C. M. and Fitz, N. F. and Carter, A. Y. and Castranio, E. L. and Kamboh, H. I. and Reeves, V. L. and others},
  title   = {{Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-04412-2},
  pmid    = {28655926},
  url     = {https://doi.org/10.1038/s41598-017-04412-2}
}

@article{picard2021-34343616,
  author  = {Picard, K. and Bisht, K. and Poggini, S. and Garofalo, S. and Golia, M. T. and Basilico, B. and Abdallah, F. and Ciano Albanese, N. and others},
  title   = {{Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2021},
  doi     = {10.1016/j.bbi.2021.07.022},
  pmid    = {34343616},
  url     = {https://doi.org/10.1016/j.bbi.2021.07.022}
}

@article{ocanas2023-37587511,
  author  = {Ocañas, SR. and Pham, K. D. and Cox, J. E. J. and Keck, A. W. and Ko, S. and Ampadu, F. A. and Porter, H. L. and Ansere, V. A. and others},
  title   = {{Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02870-2},
  pmid    = {37587511},
  url     = {https://doi.org/10.1186/s12974-023-02870-2}
}

@article{zhou2018-30038567,
  author  = {Zhou, Y. and Ulland, T. K. and Colonna, M.},
  title   = {{TREM2-Dependent Effects on Microglia in Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00202},
  pmid    = {30038567},
  url     = {https://doi.org/10.3389/fnagi.2018.00202}
}

@article{bordeleau2020-32891154,
  author  = {Bordeleau, M. and Lacabanne, C. and Fernández de Cossío, L. and Vernoux, N. and Savage, J. C. and González-Ibáñez, F. and MÈ, Tremblay},
  title   = {{Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01914-1},
  pmid    = {32891154},
  url     = {https://doi.org/10.1186/s12974-020-01914-1}
}

@article{dardiotis2017-28214109,
  author  = {Dardiotis, E. and Siokas, V. and Pantazi, E. and Dardioti, M. and Rikos, D. and Xiromerisiou, G. and Markou, A. and Papadimitriou, D. and others},
  title   = {{A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.01.015},
  pmid    = {28214109},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.01.015}
}

@article{claes2019-30442540,
  author  = {Claes, C. and Van Den Daele, J. and Boon, R. and Schouteden, S. and Colombo, A. and Monasor, L. S. and Fiers, M. and Ordovás, L. and others},
  title   = {{Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2019},
  doi     = {10.1016/j.jalz.2018.09.006},
  pmid    = {30442540},
  url     = {https://doi.org/10.1016/j.jalz.2018.09.006}
}

@article{morris2019-29705945,
  author  = {Morris, G. and Berk, M. and Maes, M. and Puri, B. K.},
  title   = {{Could Alzheimer's Disease Originate in the Periphery and If So How So?}},
  journal = {Molecular neurobiology},
  year    = {2019},
  doi     = {10.1007/s12035-018-1092-y},
  pmid    = {29705945},
  url     = {https://doi.org/10.1007/s12035-018-1092-y}
}

@article{piccioni2021-33652870,
  author  = {Piccioni, G. and Mango, D. and Saidi, A. and Corbo, M. and Nisticò, R.},
  title   = {{Targeting Microglia-Synapse Interactions in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22052342},
  pmid    = {33652870},
  url     = {https://doi.org/10.3390/ijms22052342}
}

@article{zhao2022-35717259,
  author  = {Zhao, P. and Xu, Y. and Jiang, L. L. and Fan, X. and Ku, Z. and Li, L. and Liu, X. and Deng, M. and others},
  title   = {{LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00550-y},
  pmid    = {35717259},
  url     = {https://doi.org/10.1186/s13024-022-00550-y}
}

@article{shi2025-38769824,
  author  = {Shi, Q. and Gutierrez, R. A. and Bhat, M. A.},
  title   = {{Microglia, Trem2, and Neurodegeneration}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2025},
  doi     = {10.1177/10738584241254118},
  pmid    = {38769824},
  url     = {https://doi.org/10.1177/10738584241254118}
}

@article{giau2019-30917570,
  author  = {Giau, V. V. and Senanarong, V. and Bagyinszky, E. and An, S. S. A. and Kim, S.},
  title   = {{Analysis of 50 Neurodegenerative Genes in Clinically Diagnosed Early-Onset Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2019},
  doi     = {10.3390/ijms20061514},
  pmid    = {30917570},
  url     = {https://doi.org/10.3390/ijms20061514}
}

@article{ito2011-21956652,
  author  = {Ito, Hiroaki and Hamerman, Jessica A.},
  title   = {{TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells}},
  journal = {European Journal of Immunology},
  year    = {2011},
  doi     = {10.1002/eji.201141679},
  pmid    = {21956652},
  url     = {https://doi.org/10.1002/eji.201141679}
}

@article{jin2025-40801241,
  author  = {Jin, Zhihui and Lu, Yan and Tang, Huifang and Cui, Huashun},
  title   = {{Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non-human primate models}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70472},
  pmid    = {40801241},
  url     = {https://doi.org/10.1002/alz.70472}
}

@article{hovde2025-41216966,
  author  = {Hovde, Moriah J and Maaser-Hecker, Anna and Bae, Jun-Seok and Tanzi, Rudolph E},
  title   = {{Inhibition of Acyl-CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low-density lipoprotein receptor 1 (LRP1)-dependent phagocytosis of amyloid beta protein in microglia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70879},
  pmid    = {41216966},
  url     = {https://doi.org/10.1002/alz.70879}
}

@article{dean2024-39032157,
  author  = {Dean, Hunter B and Greer, Rory A and Yang, Shan-Zhong and Elston, Daniel S and Brett, Thomas J and Roberson, Erik D and Song, Yuhua},
  title   = {{Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14124},
  pmid    = {39032157},
  url     = {https://doi.org/10.1002/alz.14124}
}

@article{danhash2025-40843775,
  author  = {Danhash, Emma P and Verbeck, Anthony C and Western, Daniel and Díaz-Pacheco, Andrea S and Galasso, Grant and You, Shih-Feng and Huang, Guangming and Starr, Emma and others},
  title   = {{Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70580},
  pmid    = {40843775},
  url     = {https://doi.org/10.1002/alz.70580}
}

@article{messenger2025-40346446,
  author  = {Messenger, Evan J and Baar, Sydney A and Bedford, Logan M and Tsai, Andy P and Lin, Peter Bor-Chian and Ferguson, Chloe A and Xu, Guixiang and Wallace, Abigail and others},
  title   = {{PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70231},
  pmid    = {40346446},
  url     = {https://doi.org/10.1002/alz.70231}
}

@article{gomez2025-40490625,
  author  = {Gomez, Andrew R and Byun, Hyae Ran and Wu, Shaogen and Muhammad, A K M Ghulam and Ikbariyeh, Jasmine and Chen, Jaelin and Muro, Alek and Li, Lin and others},
  title   = {{Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice}},
  journal = {Nature aging},
  year    = {2025},
  doi     = {10.1038/s43587-025-00879-1},
  pmid    = {40490625},
  url     = {https://doi.org/10.1038/s43587-025-00879-1}
}

@article{bedford2025-41066163,
  author  = {Bedford, Logan M and Tutrow, Kaylee D and Hooper, Karly and Messenger, Evan J and Hernandez, Melody and Lamb, Bruce T and Meyer, Jason S and Richardson, Timothy I and others},
  title   = {{Alzheimer's disease-associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell-derived microglia-like cells}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70772},
  pmid    = {41066163},
  url     = {https://doi.org/10.1002/alz.70772}
}

@article{schauer2024-39090679,
  author  = {Schauer, Stephen P and Cho, Chang Hoon and Novikova, Gloriia and Roth, Gillie A and Lee, Julie and Sharma, Anup D and Foley, Alejandro R and Ng, Carl and others},
  title   = {{Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13921},
  pmid    = {39090679},
  url     = {https://doi.org/10.1002/alz.13921}
}

@article{vogels2019-31277708,
  author  = {Vogels, T. and Murgoci, A. N. and Hromádka, T.},
  title   = {{Intersection of pathological tau and microglia at the synapse}},
  journal = {Acta neuropathologica communications},
  year    = {2019},
  doi     = {10.1186/s40478-019-0754-y},
  pmid    = {31277708},
  url     = {https://doi.org/10.1186/s40478-019-0754-y}
}

@article{li2019-29663649,
  author  = {Li, C. and Zhao, B. and Lin, C. and Gong, Z. and An, X.},
  title   = {{TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling}},
  journal = {Cell biology international},
  year    = {2019},
  doi     = {10.1002/cbin.10975},
  pmid    = {29663649},
  url     = {https://doi.org/10.1002/cbin.10975}
}

@article{sessa2004-15548205,
  author  = {Sessa, G. and Podini, P. and Mariani, M. and Meroni, A. and Spreafico, R. and Sinigaglia, F. and Colonna, M. and Panina, P. and others},
  title   = {{Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia}},
  journal = {The European journal of neuroscience},
  year    = {2004},
  doi     = {10.1111/j.1460-9568.2004.03729.x},
  pmid    = {15548205},
  url     = {https://doi.org/10.1111/j.1460-9568.2004.03729.x}
}

@article{lue2015-25186950,
  author  = {Lue, L. F. and Schmitz, C. T. and Serrano, G. and Sue, L. I. and Beach, T. G. and Walker, D. G.},
  title   = {{TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2015},
  doi     = {10.1111/bpa.12190},
  pmid    = {25186950},
  url     = {https://doi.org/10.1111/bpa.12190}
}

@article{ydens2012-22818207,
  author  = {Ydens, E. and Cauwels, A. and Asselbergh, B. and Goethals, S. and Peeraer, L. and Lornet, G. and Almeida-Souza, L. and Van Ginderachter, J. A. and others},
  title   = {{Acute injury in the peripheral nervous system triggers an alternative macrophage response}},
  journal = {Journal of neuroinflammation},
  year    = {2012},
  doi     = {10.1186/1742-2094-9-176},
  pmid    = {22818207},
  url     = {https://doi.org/10.1186/1742-2094-9-176}
}

@article{schmid2009-19393017,
  author  = {Schmid, C. D. and Melchior, B. and Masek, K. and Puntambekar, S. S. and Danielson, P. E. and Lo, D. D. and Sutcliffe, J. G. and Carson, M. J.},
  title   = {{Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.05984.x},
  pmid    = {19393017},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.05984.x}
}

@article{clayton2017-29311768,
  author  = {Clayton, K. A. and Van Enoo, A. A. and Ikezu, T.},
  title   = {{Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy}},
  journal = {Frontiers in neuroscience},
  year    = {2017},
  doi     = {10.3389/fnins.2017.00680},
  pmid    = {29311768},
  url     = {https://doi.org/10.3389/fnins.2017.00680}
}

@article{nazmi2019-30680794,
  author  = {Nazmi, A. and Field, R. H. and Griffin, E. W. and Haugh, O. and Hennessy, E. and Cox, D. and Reis, R. and Tortorelli, L. and others},
  title   = {{Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23592},
  pmid    = {30680794},
  url     = {https://doi.org/10.1002/glia.23592}
}

@article{ulrich2016-26854967,
  author  = {Ulrich, J. D. and Holtzman, D. M.},
  title   = {{TREM2 Function in Alzheimer's Disease and Neurodegeneration}},
  journal = {ACS chemical neuroscience},
  year    = {2016},
  doi     = {10.1021/acschemneuro.5b00313},
  pmid    = {26854967},
  url     = {https://doi.org/10.1021/acschemneuro.5b00313}
}

@article{piirainen2017-28185874,
  author  = {Piirainen, S. and Youssef, A. and Song, C. and Kalueff, A. V. and Landreth, G. E. and Malm, T. and Tian, L.},
  title   = {{Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2017},
  doi     = {10.1016/j.neubiorev.2017.01.046},
  pmid    = {28185874},
  url     = {https://doi.org/10.1016/j.neubiorev.2017.01.046}
}

@article{caldeira2017-28912710,
  author  = {Caldeira, C. and Cunha, C. and Vaz, A. R. and Falcão, A. S. and Barateiro, A. and Seixas, E. and Fernandes, A. and Brites, D.},
  title   = {{Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00277},
  pmid    = {28912710},
  url     = {https://doi.org/10.3389/fnagi.2017.00277}
}

@article{cheng2018-29599291,
  author  = {Cheng, Q. and Danao, J. and Talreja, S. and Wen, P. and Yin, J. and Sun, N. and Li, C. M. and Chui, D. and others},
  title   = {{TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function}},
  journal = {The Journal of biological chemistry},
  year    = {2018},
  doi     = {10.1074/jbc.ra118.001848},
  pmid    = {29599291},
  url     = {https://doi.org/10.1074/jbc.ra118.001848}
}

@article{baizabalcarvallo2016-26891767,
  author  = {Baizabal-Carvallo, J. F. and Jankovic, J.},
  title   = {{Parkinsonism, movement disorders and genetics in frontotemporal dementia}},
  journal = {Nature reviews. Neurology},
  year    = {2016},
  doi     = {10.1038/nrneurol.2016.14},
  pmid    = {26891767},
  url     = {https://doi.org/10.1038/nrneurol.2016.14}
}

@article{yang2020-32635934,
  author  = {Yang, J. and Fu, Z. and Zhang, X. and Xiong, M. and Meng, L. and Zhang, Z.},
  title   = {{TREM2 ectodomain and its soluble form in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01878-2},
  pmid    = {32635934},
  url     = {https://doi.org/10.1186/s12974-020-01878-2}
}

@article{varvel2015-26458770,
  author  = {Varvel, N. H. and Grathwohl, S. A. and Degenhardt, K. and Resch, C. and Bosch, A. and Jucker, M. and Neher, J. J.},
  title   = {{Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease}},
  journal = {The Journal of experimental medicine},
  year    = {2015},
  doi     = {10.1084/jem.20150478},
  pmid    = {26458770},
  url     = {https://doi.org/10.1084/jem.20150478}
}

@article{guo2023-37133566,
  author  = {Guo, X. and Li, B. and Wen, C. and Zhang, F. and Xiang, X. and Nie, L. and Chen, J. and Mao, L.},
  title   = {{TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2023},
  doi     = {10.1007/s00018-023-04786-9},
  pmid    = {37133566},
  url     = {https://doi.org/10.1007/s00018-023-04786-9}
}

@article{jendresen2017-28320424,
  author  = {Jendresen, C. and Årskog, V. and Daws, M. R. and Nilsson, L. N.},
  title   = {{The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway}},
  journal = {Journal of neuroinflammation},
  year    = {2017},
  doi     = {10.1186/s12974-017-0835-4},
  pmid    = {28320424},
  url     = {https://doi.org/10.1186/s12974-017-0835-4}
}

@article{roussos2015-25499537,
  author  = {Roussos, P. and Katsel, P. and Fam, P. and Tan, W. and Purohit, D. P. and Haroutunian, V.},
  title   = {{The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.10.013},
  pmid    = {25499537},
  url     = {https://doi.org/10.1016/j.jalz.2014.10.013}
}

@article{fracassi2023-35816404,
  author  = {Fracassi, A. and Marcatti, M. and Tumurbaatar, B. and Woltjer, R. and Moreno, S. and Taglialatela, G.},
  title   = {{TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2023},
  doi     = {10.1111/bpa.13108},
  pmid    = {35816404},
  url     = {https://doi.org/10.1111/bpa.13108}
}

@article{raha2017-27662313,
  author  = {Raha, A. A. and Henderson, J. W. and Stott, SR. and Vuono, R. and Foscarin, S. and Friedland, R. P. and Zaman, S. H. and Raha-Chowdhury, R.},
  title   = {{Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160663},
  pmid    = {27662313},
  url     = {https://doi.org/10.3233/jad-160663}
}

@article{mohle2016-26984535,
  author  = {Möhle, L. and Israel, N. and Paarmann, K. and Krohn, M. and Pietkiewicz, S. and Müller, A. and Lavrik, I. N. and Buguliskis, J. S. and others},
  title   = {{Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes}},
  journal = {Acta neuropathologica communications},
  year    = {2016},
  doi     = {10.1186/s40478-016-0293-8},
  pmid    = {26984535},
  url     = {https://doi.org/10.1186/s40478-016-0293-8}
}

@article{dayananda2023-36174883,
  author  = {Dayananda, K. K. and Ahmed, S. and Wang, D. and Polis, B. and Islam, R. and Kaffman, A.},
  title   = {{Early life stress impairs synaptic pruning in the developing hippocampus}},
  journal = {Brain, behavior, and immunity},
  year    = {2023},
  doi     = {10.1016/j.bbi.2022.09.014},
  pmid    = {36174883},
  url     = {https://doi.org/10.1016/j.bbi.2022.09.014}
}

@article{molgora2023-36989543,
  author  = {Molgora, M. and Liu, Y. A. and Colonna, M. and Cella, M.},
  title   = {{TREM2: A new player in the tumor microenvironment}},
  journal = {Seminars in immunology},
  year    = {2023},
  doi     = {10.1016/j.smim.2023.101739},
  pmid    = {36989543},
  url     = {https://doi.org/10.1016/j.smim.2023.101739}
}

@article{kober2020-33090700,
  author  = {Kober, D. L. and Stuchell-Brereton, M. D. and Kluender, C. E. and Dean, H. B. and Strickland, M. R. and Steinberg, D. F. and Nelson, S. S. and Baban, B. and others},
  title   = {{Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12194},
  pmid    = {33090700},
  url     = {https://doi.org/10.1002/alz.12194}
}

@article{yang2021-33567283,
  author  = {Yang, H. S. and Onos, K. D. and Choi, K. and Keezer, K. J. and Skelly, D. A. and Carter, G. W. and Howell, G. R.},
  title   = {{Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.108739},
  pmid    = {33567283},
  url     = {https://doi.org/10.1016/j.celrep.2021.108739}
}

@article{yang2023-36259513,
  author  = {Yang, T. and Zhang, S. and Yuan, H. and Wang, Y. and Cai, L. and Chen, H. and Wang, X. and Song, D. and others},
  title   = {{Platinum-Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2023},
  doi     = {10.1002/anie.202213337},
  pmid    = {36259513},
  url     = {https://doi.org/10.1002/anie.202213337}
}

@article{xue2022-35847502,
  author  = {Xue, T. and Ji, J. and Sun, Y. and Huang, X. and Cai, Z. and Yang, J. and Guo, W. and Guo, R. and others},
  title   = {{Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury}},
  journal = {Acta pharmaceutica Sinica. B},
  year    = {2022},
  doi     = {10.1016/j.apsb.2021.10.012},
  pmid    = {35847502},
  url     = {https://doi.org/10.1016/j.apsb.2021.10.012}
}

@article{pottier2016-27658901,
  author  = {Pottier, C. and Ravenscroft, T. A. and Brown, P. H. and Finch, N. A. and Baker, M. and Parsons, M. and Asmann, Y. W. and Ren, Y. and others},
  title   = {{TYROBP genetic variants in early-onset Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.07.028},
  pmid    = {27658901},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.07.028}
}

@article{cooperknock2017-28302159,
  author  = {Cooper-Knock, J. and Green, C. and Altschuler, G. and Wei, W. and Bury, J. J. and Heath, P. R. and Wyles, M. and Gelsthorpe, C. and others},
  title   = {{A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis}},
  journal = {Acta neuropathologica communications},
  year    = {2017},
  doi     = {10.1186/s40478-017-0424-x},
  pmid    = {28302159},
  url     = {https://doi.org/10.1186/s40478-017-0424-x}
}

@article{lin2023-36524682,
  author  = {Lin, P. B. and Tsai, A. P. and Soni, D. and Lee-Gosselin, A. and Moutinho, M. and Puntambekar, S. S. and Landreth, G. E. and Lamb, B. T. and others},
  title   = {{INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.12849},
  pmid    = {36524682},
  url     = {https://doi.org/10.1002/alz.12849}
}

@article{wang2022-36068223,
  author  = {Wang, Y. and Cao, C. and Zhu, Y. and Fan, H. and Liu, Q. and Liu, Y. and Chen, K. and Wu, Y. and others},
  title   = {{TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria}},
  journal = {Cell death \& disease},
  year    = {2022},
  doi     = {10.1038/s41419-022-05193-x},
  pmid    = {36068223},
  url     = {https://doi.org/10.1038/s41419-022-05193-x}
}

@article{warneckeeberz2016-26631031,
  author  = {Warnecke-Eberz, U. and Metzger, R. and Hölscher, A. H. and Drebber, U. and Bollschweiler, E.},
  title   = {{Diagnostic marker signature for esophageal cancer from transcriptome analysis}},
  journal = {Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  year    = {2016},
  doi     = {10.1007/s13277-015-4400-4},
  pmid    = {26631031},
  url     = {https://doi.org/10.1007/s13277-015-4400-4}
}

@article{qu2020-33139402,
  author  = {Qu, W. and Li, L.},
  title   = {{Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.2193-20.2020},
  pmid    = {33139402},
  url     = {https://doi.org/10.1523/jneurosci.2193-20.2020}
}

@article{jadhav2020-33115519,
  author  = {Jadhav, V. S. and Lin, P. B. C. and Pennington, T. and Di Prisco, G. V. and Jannu, A. J. and Xu, G. and Moutinho, M. and Zhang, J. and others},
  title   = {{Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00409-0},
  pmid    = {33115519},
  url     = {https://doi.org/10.1186/s13024-020-00409-0}
}

@article{schmid2002-12472885,
  author  = {Schmid, Christoph D. and Sautkulis, Lauren N. and Danielson, Patria E. and Cooper, Judith and Hasel, Karl W. and Hilbush, Brian S. and Sutcliffe, J. Gregor and Carson, Monica J.},
  title   = {{Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia}},
  journal = {Journal of Neurochemistry},
  year    = {2002},
  doi     = {10.1046/j.1471-4159.2002.01243.x},
  pmid    = {12472885},
  url     = {https://doi.org/10.1046/j.1471-4159.2002.01243.x}
}

@article{daws2003-12847223,
  author  = {Daws, Michael R. and Sullam, Paul M. and Niemi, Eréne C. and Chen, Thomas T. and Tchao, Nadia K. and Seaman, William E.},
  title   = {{Pattern Recognition by TREM-2: Binding of Anionic Ligands}},
  journal = {The Journal of Immunology},
  year    = {2003},
  doi     = {10.4049/jimmunol.171.2.594},
  pmid    = {12847223},
  url     = {https://doi.org/10.4049/jimmunol.171.2.594}
}

@article{kloske2023-36975090,
  author  = {Kloske, Courtney M and Barnum, Christopher J and Batista, Andre F and Bradshaw, Elizabeth M and Brickman, Adam M and Bu, Guojun and Dennison, Jessica and Gearon, Mary D and others},
  title   = {{APOE and immunity: Research highlights}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.13020},
  pmid    = {36975090},
  url     = {https://doi.org/10.1002/alz.13020}
}

@article{rosner2026-41435829,
  author  = {Rosner, Dalya and Sun, Jiahong and Cacace, Rita and Yee, Angie and Wagh, Chaitanya and Rychkova, Anna and Dunlap, Mariah and Gulbranson, Daniel and others},
  title   = {{The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states}},
  journal = {Neuron},
  year    = {2026},
  doi     = {10.1016/j.neuron.2025.11.022},
  pmid    = {41435829},
  url     = {https://doi.org/10.1016/j.neuron.2025.11.022}
}

@article{lv2026-42865133,
  author  = {Lv, Yaqing and Shi, Mingpeng and Zhao, Yongfei and Yu, Yi and Lv, Jiawei and Zhao, Hai},
  title   = {{Context-dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer}},
  journal = {Clinical and translational medicine},
  year    = {2026},
  doi     = {10.1002/ctm2.70863},
  pmid    = {42865133},
  url     = {https://doi.org/10.1002/ctm2.70863}
}

@article{abdulkhaliq2026-41213496,
  author  = {Abdulkhaliq, Altaf A and Alasiri, Glowi and Almoghrabi, Yousef and Kim, Bonglee and Khan, Johra and Ajoolabady, Amir and Ren, Jun and Tuomilehto, Jaakko and others},
  title   = {{Role of TREM2 in neuroinflammation}},
  journal = {Experimental neurology},
  year    = {2026},
  doi     = {10.1016/j.expneurol.2025.115547},
  pmid    = {41213496},
  url     = {https://doi.org/10.1016/j.expneurol.2025.115547}
}

@article{mallach2021-34704019,
  author  = {Mallach, Anna and Gobom, Johan and Zetterberg, Henrik and Hardy, John and Piers, Thomas M and Wray, Selina and Pocock, Jennifer M},
  title   = {{The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles}},
  journal = {Brain communications},
  year    = {2021},
  doi     = {10.1093/braincomms/fcab009},
  pmid    = {34704019},
  url     = {https://doi.org/10.1093/braincomms/fcab009}
}

@article{konstantoulea2026-41770935,
  author  = {Konstantoulea, Katerina and Ramakers, Meine and Borrie, Sarah C and T'Syen, Dries and Moechars, Daan and Sliwinska, Malgorzata A and Pradhan, Brajabandhu and Albertini, Giulia and others},
  title   = {{Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2026},
  doi     = {10.1073/pnas.2516774123},
  pmid    = {41770935},
  url     = {https://doi.org/10.1073/pnas.2516774123}
}

@article{neumann2007-17239445,
  author  = {Neumann, H. and Takahashi, K.},
  title   = {{Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis}},
  journal = {Journal of neuroimmunology},
  year    = {2007},
  doi     = {10.1016/j.jneuroim.2006.11.032},
  pmid    = {17239445},
  url     = {https://doi.org/10.1016/j.jneuroim.2006.11.032}
}

@article{rae2007-17597598,
  author  = {Rae, F. and Woods, K. and Sasmono, T. and Campanale, N. and Taylor, D. and Ovchinnikov, D. A. and Grimmond, S. M. and Hume, D. A. and others},
  title   = {{Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter}},
  journal = {Developmental biology},
  year    = {2007},
  doi     = {10.1016/j.ydbio.2007.05.027},
  pmid    = {17597598},
  url     = {https://doi.org/10.1016/j.ydbio.2007.05.027}
}

@article{wes2016-27100611,
  author  = {Wes, P. D. and Sayed, F. A. and Bard, F. and Gan, L.},
  title   = {{Targeting microglia for the treatment of Alzheimer's Disease}},
  journal = {Glia},
  year    = {2016},
  doi     = {10.1002/glia.22988},
  pmid    = {27100611},
  url     = {https://doi.org/10.1002/glia.22988}
}

@article{humphrey2006-16418779,
  author  = {Humphrey, M. B. and Daws, M. R. and Spusta, S. C. and Niemi, E. C. and Torchia, J. A. and Lanier, L. L. and Seaman, W. E. and Nakamura, M. C.},
  title   = {{TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function}},
  journal = {Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year    = {2006},
  doi     = {10.1359/jbmr.051016},
  pmid    = {16418779},
  url     = {https://doi.org/10.1359/jbmr.051016}
}

@article{zhang2018-29621548,
  author  = {Zhang, Y. and Feng, S. and Nie, K. and Li, Y. and Gao, Y. and Gan, R. and Wang, L. and Li, B. and others},
  title   = {{TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2018},
  doi     = {10.1016/j.bbrc.2018.03.226},
  pmid    = {29621548},
  url     = {https://doi.org/10.1016/j.bbrc.2018.03.226}
}

@article{chouery2008-18546367,
  author  = {Chouery, E. and Delague, V. and Bergougnoux, A. and Koussa, S. and Serre, J. L. and Mégarbané, A.},
  title   = {{Mutations in TREM2 lead to pure early-onset dementia without bone cysts}},
  journal = {Human mutation},
  year    = {2008},
  doi     = {10.1002/humu.20836},
  pmid    = {18546367},
  url     = {https://doi.org/10.1002/humu.20836}
}

@article{grassivaro2020-31818979,
  author  = {Grassivaro, F. and Menon, R. and Acquaviva, M. and Ottoboni, L. and Ruffini, F. and Bergamaschi, A. and Muzio, L. and Farina, C. and others},
  title   = {{Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.1523-19.2019},
  pmid    = {31818979},
  url     = {https://doi.org/10.1523/jneurosci.1523-19.2019}
}

@article{cheng2021-33679809,
  author  = {Cheng, X. and Wang, X. and Nie, K. and Cheng, L. and Zhang, Z. and Hu, Y. and Peng, W.},
  title   = {{Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.646523},
  pmid    = {33679809},
  url     = {https://doi.org/10.3389/fimmu.2021.646523}
}

@article{ruganzu2021-33065077,
  author  = {Ruganzu, J. B. and Zheng, Q. and Wu, X. and He, Y. and Peng, X. and Jin, H. and Zhou, J. and Ma, R. and others},
  title   = {{TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway}},
  journal = {Experimental neurology},
  year    = {2021},
  doi     = {10.1016/j.expneurol.2020.113506},
  pmid    = {33065077},
  url     = {https://doi.org/10.1016/j.expneurol.2020.113506}
}

@article{jiang2013-23407992,
  author  = {Jiang, T. and Yu, J. T. and Zhu, X. C. and Tan, L.},
  title   = {{TREM2 in Alzheimer's disease}},
  journal = {Molecular neurobiology},
  year    = {2013},
  doi     = {10.1007/s12035-013-8424-8},
  pmid    = {23407992},
  url     = {https://doi.org/10.1007/s12035-013-8424-8}
}

@article{hu2014-24002183,
  author  = {Hu, N. and Tan, M. S. and Yu, J. T. and Sun, L. and Tan, L. and Wang, Y. L. and Jiang, T.},
  title   = {{Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-130854},
  pmid    = {24002183},
  url     = {https://doi.org/10.3233/jad-130854}
}

@article{hamerman2016-26683155,
  author  = {Hamerman, J. A. and Pottle, J. and Ni, M. and He, Y. and Zhang, Z. Y. and Buckner, J. H.},
  title   = {{Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases}},
  journal = {Immunological reviews},
  year    = {2016},
  doi     = {10.1111/imr.12381},
  pmid    = {26683155},
  url     = {https://doi.org/10.1111/imr.12381}
}

@article{chen2021-33729626,
  author  = {Chen, M. J. and Ramesha, S. and Weinstock, L. D. and Gao, T. and Ping, L. and Xiao, H. and Dammer, E. B. and Duong, D. D. and others},
  title   = {{Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer's disease}},
  journal = {Journal of neuroscience research},
  year    = {2021},
  doi     = {10.1002/jnr.24829},
  pmid    = {33729626},
  url     = {https://doi.org/10.1002/jnr.24829}
}

@article{jay2019-31265185,
  author  = {Jay, T. R. and von Saucken, V. E. and Muñoz, B. and Codocedo, J. F. and Atwood, B. K. and Lamb, B. T. and Landreth, G. E.},
  title   = {{TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23664},
  pmid    = {31265185},
  url     = {https://doi.org/10.1002/glia.23664}
}

@article{wyatt2017-28601603,
  author  = {Wyatt, S. K. and Witt, T. and Barbaro, N. M. and Cohen-Gadol, A. A. and Brewster, A. L.},
  title   = {{Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy}},
  journal = {Experimental neurology},
  year    = {2017},
  doi     = {10.1016/j.expneurol.2017.06.009},
  pmid    = {28601603},
  url     = {https://doi.org/10.1016/j.expneurol.2017.06.009}
}

@article{saber2017-26976047,
  author  = {Saber, M. and Kokiko-Cochran, O. and Puntambekar, S. S. and Lathia, J. D. and Lamb, B. T.},
  title   = {{Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury}},
  journal = {Journal of neurotrauma},
  year    = {2017},
  doi     = {10.1089/neu.2016.4401},
  pmid    = {26976047},
  url     = {https://doi.org/10.1089/neu.2016.4401}
}

@article{lee2021-34965428,
  author  = {Lee, S. H. and Rezzonico, M. G. and Friedman, B. A. and Huntley, M. H. and Meilandt, W. J. and Pandey, S. and Chen, Y. J. and Easton, A. and others},
  title   = {{TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.110158},
  pmid    = {34965428},
  url     = {https://doi.org/10.1016/j.celrep.2021.110158}
}

@article{zheng2018-30532704,
  author  = {Zheng, H. and Cheng, B. and Li, Y. and Li, X. and Chen, X. and Zhang, Y. W.},
  title   = {{TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00395},
  pmid    = {30532704},
  url     = {https://doi.org/10.3389/fnagi.2018.00395}
}

@article{zhong2017-28680398,
  author  = {Zhong, L. and Zhang, Z. L. and Li, X. and Liao, C. and Mou, P. and Wang, T. and Wang, Z. and others},
  title   = {{TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00204},
  pmid    = {28680398},
  url     = {https://doi.org/10.3389/fnagi.2017.00204}
}

@article{celarain2016-27051467,
  author  = {Celarain, N. and Sánchez-Ruiz de Gordoa, J. and Zelaya, M. V. and Roldán, M. and Larumbe, R. and Pulido, L. and Echavarri, C. and Mendioroz, M.},
  title   = {{TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus}},
  journal = {Clinical epigenetics},
  year    = {2016},
  doi     = {10.1186/s13148-016-0202-9},
  pmid    = {27051467},
  url     = {https://doi.org/10.1186/s13148-016-0202-9}
}

@article{li2021-34708251,
  author  = {Li, Y. and Laws, S. M. and Miles, L. A. and Wiley, J. S. and Huang, X. and Masters, C. L. and Gu, B. J.},
  title   = {{Genomics of Alzheimer's disease implicates the innate and adaptive immune systems}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2021},
  doi     = {10.1007/s00018-021-03986-5},
  pmid    = {34708251},
  url     = {https://doi.org/10.1007/s00018-021-03986-5}
}

@article{song2022-35017668,
  author  = {Song, S. and Yu, L. and Hasan, M. N. and Paruchuri, S. S. and Mullett, S. J. and Sullivan, M. L. G. and Fiesler, V. M. and Young, C. B. and others},
  title   = {{Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice}},
  journal = {Communications biology},
  year    = {2022},
  doi     = {10.1038/s42003-021-02984-4},
  pmid    = {35017668},
  url     = {https://doi.org/10.1038/s42003-021-02984-4}
}

@article{sanjay2022-35670898,
  author  = {Sanjay and Shin, J. H. and Park, M. and Lee, H. J.},
  title   = {{Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model}},
  journal = {Molecular neurobiology},
  year    = {2022},
  doi     = {10.1007/s12035-022-02873-9},
  pmid    = {35670898},
  url     = {https://doi.org/10.1007/s12035-022-02873-9}
}

@article{mangale2020-32449994,
  author  = {Mangale, V. and Syage, A. R. and Ekiz, H. A. and Skinner, D. D. and Cheng, Y. and Stone, C. L. and Brown, R. M. and O'Connell, R. M. and others},
  title   = {{Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system}},
  journal = {Glia},
  year    = {2020},
  doi     = {10.1002/glia.23844},
  pmid    = {32449994},
  url     = {https://doi.org/10.1002/glia.23844}
}

@article{xu2023-36829205,
  author  = {Xu, J. and Zhang, L. and Li, M. and He, X. and Luo, J. and Wu, R. and Hong, Z. and Zheng, H. and others},
  title   = {{TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02741-w},
  pmid    = {36829205},
  url     = {https://doi.org/10.1186/s12974-023-02741-w}
}

@article{fitz2020-32703241,
  author  = {Fitz, N. F. and Wolfe, C. M. and Playso, B. E. and Biedrzycki, R. J. and Lu, Y. and Nam, K. N. and Lefterov, I. and Koldamova, R.},
  title   = {{Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00394-4},
  pmid    = {32703241},
  url     = {https://doi.org/10.1186/s13024-020-00394-4}
}

@article{kurisu2019-30523715,
  author  = {Kurisu, K. and Zheng, Z. and Kim, J. Y. and Shi, J. and Kanoke, A. and Liu, J. and Hsieh, C. L. and Yenari, M. A.},
  title   = {{Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke}},
  journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year    = {2019},
  doi     = {10.1177/0271678x18817282},
  pmid    = {30523715},
  url     = {https://doi.org/10.1177/0271678x18817282}
}

@article{jiao2014-24866402,
  author  = {Jiao, B. and Liu, X. and Tang, B. and Hou, L. and Zhou, L. and Zhang, F. and Zhou, Y. and Guo, J. and others},
  title   = {{Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.04.025},
  pmid    = {24866402},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.04.025}
}

@article{tran2023-36803190,
  author  = {Tran, K. M. and Kawauchi, S. and Kramár, E. A. and Rezaie, N. and Liang, H. Y. and Sakr, J. S. and Gomez-Arboledas, A. and Arreola, M. A. and others},
  title   = {{A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00598-4},
  pmid    = {36803190},
  url     = {https://doi.org/10.1186/s13024-023-00598-4}
}

@article{peng2023-36662361,
  author  = {Peng, X. and Guo, H. and Zhang, X. and Yang, Z. and Ruganzu, J. B. and Wu, X. and Bi, W. and others},
  title   = {{TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-023-03217-x},
  pmid    = {36662361},
  url     = {https://doi.org/10.1007/s12035-023-03217-x}
}

@article{khantakova2022-35746551,
  author  = {Khantakova, D. and Brioschi, S. and Molgora, M.},
  title   = {{Exploring the Impact of TREM2 in Tumor-Associated Macrophages}},
  journal = {Vaccines},
  year    = {2022},
  doi     = {10.3390/vaccines10060943},
  pmid    = {35746551},
  url     = {https://doi.org/10.3390/vaccines10060943}
}

@article{sirkis2016-27589997,
  author  = {Sirkis, D. W. and Bonham, L. W. and Aparicio, R. E. and Geier, E. G. and Ramos, E. M. and Wang, Q. and Karydas, A. and Miller, Z. A. and others},
  title   = {{Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression}},
  journal = {Acta neuropathologica communications},
  year    = {2016},
  doi     = {10.1186/s40478-016-0367-7},
  pmid    = {27589997},
  url     = {https://doi.org/10.1186/s40478-016-0367-7}
}

@article{lichtenthaler2022-34689040,
  author  = {Lichtenthaler, S. F. and Tschirner, S. K. and Steiner, H.},
  title   = {{Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2}},
  journal = {Current opinion in neurobiology},
  year    = {2022},
  doi     = {10.1016/j.conb.2021.09.003},
  pmid    = {34689040},
  url     = {https://doi.org/10.1016/j.conb.2021.09.003}
}

@article{church2022-36517889,
  author  = {Church, K. A. and Rodriguez, D. and Vanegas, D. and Gutierrez, I. L. and Cardona, S. M. and Madrigal, J. L. M. and Kaur, T. and Cardona, A. E.},
  title   = {{Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02659-9},
  pmid    = {36517889},
  url     = {https://doi.org/10.1186/s12974-022-02659-9}
}

@article{reich2020-33613545,
  author  = {Reich, M. and Paris, I. and Ebeling, M. and Dahm, N. and Schweitzer, C. and Reinhardt, D. and Schmucki, R. and Prasad, M. and others},
  title   = {{Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.617860},
  pmid    = {33613545},
  url     = {https://doi.org/10.3389/fimmu.2020.617860}
}