% alzhub.org library filter
% Source: https://alzhub.org/research?category=genetics_genes
% 500 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{nudelman2023-37801072,
  author  = {Nudelman, Kelly N H and Jackson, Trever and Rumbaugh, Malia and Eloyan, Ani and Abreu, Marco and Dage, Jeffrey L and Snoddy, Casey and Faber, Kelley M and others},
  title   = {{Pathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.13482},
  pmid    = {37801072},
  url     = {https://doi.org/10.1002/alz.13482}
}

@article{charidimou2018-29386280,
  author  = {Charidimou, A. and Friedrich, J. O. and Greenberg, S. M. and Viswanathan, A.},
  title   = {{Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000005030},
  pmid    = {29386280},
  url     = {https://doi.org/10.1212/wnl.0000000000005030}
}

@article{oxtoby2018-29579160,
  author  = {Oxtoby, N. P. and Young, A. L. and Cash, D. M. and Benzinger, T. L. S. and Fagan, A. M. and Morris, J. C. and Bateman, R. J. and Fox, N. C. and others},
  title   = {{Data-driven models of dominantly-inherited Alzheimer's disease progression}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awy050},
  pmid    = {29579160},
  url     = {https://doi.org/10.1093/brain/awy050}
}

@article{jansen2019-30617256,
  author  = {Jansen, Iris E. and Savage, Jeanne E. and Watanabe, Kyoko and Bryois, Julien and Williams, Dylan M. and Steinberg, Stacy and Sealock, Julia and Karlsson, Ida and others},
  title   = {{Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk}},
  journal = {Nature Genetics},
  year    = {2019},
  doi     = {10.1038/s41588-018-0311-9},
  pmid    = {30617256},
  url     = {https://doi.org/10.1038/s41588-018-0311-9}
}

@article{carrasquillo2010-20554627,
  author  = {Carrasquillo, M. M. and Belbin, O. and Hunter, T. A. and Ma, L. and Bisceglio, G. D. and Zou, F. and Crook, J. E. and others},
  title   = {{Replication of CLU, CR1, and PICALM associations with alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2010.147},
  pmid    = {20554627},
  url     = {https://doi.org/10.1001/archneurol.2010.147}
}

@article{reitz2011-21220680,
  author  = {Reitz, C. and Cheng, R. and Rogaeva, E. and Lee, J. H. and Tokuhiro, S. and Zou, F. and Bettens, K. and Sleegers, K. and others},
  title   = {{Meta-analysis of the association between variants in SORL1 and Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.346},
  pmid    = {21220680},
  url     = {https://doi.org/10.1001/archneurol.2010.346}
}

@article{lambert2013-24162737,
  author  = {Lambert, Jean‐Charles and Ibrahim‐Verbaas, Carla A. and Harold, Denise H. and Naj, Adam Christian and Sims, Rebecca and Bellenguez, Céline and others},
  title   = {{Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2013},
  doi     = {10.1038/ng.2802},
  pmid    = {24162737},
  url     = {https://doi.org/10.1038/ng.2802}
}

@article{harold2009-19734902,
  author  = {Harold, Denise H. and Abraham, Richard and Hollingworth, Paul and Sims, Rebecca and Gerrish, Amy and Hamshere, Marian L. and Pahwa, Jaspreet Singh and Moskvina, Valentina and others},
  title   = {{Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2009},
  doi     = {10.1038/ng.440},
  pmid    = {19734902},
  url     = {https://doi.org/10.1038/ng.440}
}

@article{study2011-21460840,
  author  = {{the Alzheimer's Disease Neuroimaging Initiative} and Hollingworth, Paul and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Lambert, Jean‐Charles and Carrasquillo, Minerva M. and Abraham, Richard and others},
  title   = {{Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2011},
  doi     = {10.1038/ng.803},
  pmid    = {21460840},
  url     = {https://doi.org/10.1038/ng.803}
}

@article{canevelli2014-24594196,
  author  = {Canevelli, Marco and Piscopo, Paola and Talarico, Giuseppina and Vanacore, Nicola and Blasimme, Alessandro and Crestini, Alessio and Tosto, Giuseppe and Troili, Fernanda and others},
  title   = {{Familial Alzheimer's disease sustained by presenilin 2 mutations: systematic review of literature and genotype-phenotype correlation}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2014},
  doi     = {10.1016/j.neubiorev.2014.02.010},
  pmid    = {24594196},
  url     = {https://doi.org/10.1016/j.neubiorev.2014.02.010}
}

@article{lanoiselee2017-28350801,
  author  = {Lanoiselée, H. M. and Nicolas, G. and Wallon, D. and Rovelet-Lecrux, A. and Lacour, M. and Rousseau, S. and Richard, A. C. and Pasquier, F. and others},
  title   = {{APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases}},
  journal = {PLoS medicine},
  year    = {2017},
  doi     = {10.1371/journal.pmed.1002270},
  pmid    = {28350801},
  url     = {https://doi.org/10.1371/journal.pmed.1002270}
}

@article{campion2019-30911827,
  author  = {Campion, D. and Charbonnier, C. and Nicolas, G.},
  title   = {{SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-01991-4},
  pmid    = {30911827},
  url     = {https://doi.org/10.1007/s00401-019-01991-4}
}

@article{study2009-591259cf,
  author  = {{the European Alzheimer's Disease Initiative Investigators} and Lambert, Jean‐Charles and Heath, Simon Charles and Even, Gaël and Campion, Dominique and Sleegers, Kristel and Hiltunen, Mikko and Combarros, Onofre and others},
  title   = {{Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2009},
  doi     = {10.1038/ng.439},
  url     = {https://doi.org/10.1038/ng.439}
}

@article{hock2002-12379846,
  author  = {Hock, C. and Konietzko, U. and Papassotiropoulos, A. and Wollmer, A. and Streffer, J. and von Rotz, R. C. and Davey, G. and Moritz, E. and others},
  title   = {{Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease}},
  journal = {Nature medicine},
  year    = {2002},
  doi     = {10.1038/nm783},
  pmid    = {12379846},
  url     = {https://doi.org/10.1038/nm783}
}

@article{endres2014-25344383,
  author  = {Endres, K. and Fahrenholz, F. and Lotz, J. and Hiemke, C. and Teipel, S. and Lieb, K. and Tüscher, O. and Fellgiebel, A.},
  title   = {{Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000001017},
  pmid    = {25344383},
  url     = {https://doi.org/10.1212/wnl.0000000000001017}
}

@article{schultz2024-39074479,
  author  = {Schultz, S. A. and Liu, L. and Schultz, A. P. and Fitzpatrick, C. D. and Levin, R. and Bellier, J. P. and Shirzadi, Z. and Joseph-Mathurin, N. and others},
  title   = {{γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)}},
  journal = {The Lancet. Neurology},
  year    = {2024},
  doi     = {10.1016/s1474-4422(24)00236-9},
  pmid    = {39074479},
  url     = {https://doi.org/10.1016/s1474-4422(24)00236-9}
}

@article{rogaeva2007-17220890,
  author  = {Rogaeva, E. and Meng, Y. and Lee, J. H. and Gu, Y. and Kawarai, T. and Zou, F. and Katayama, T. and Baldwin, C. T. and others},
  title   = {{The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease}},
  journal = {Nature genetics},
  year    = {2007},
  doi     = {10.1038/ng1943},
  pmid    = {17220890},
  url     = {https://doi.org/10.1038/ng1943}
}

@article{kwiatkowski2009-19251627,
  author  = {Kwiatkowski, Thomas J. and Bosco, Daryl A. and Leclerc, Aurélie and Tamrazian, Eric and Vanderburg, Charles R. and Russ, C and Davis, Adam and Gilchrist, James M. and Kasarskis, Edward J. and Munsat, T. L. and Valdmanis, Paul N. and Rouleau, Guy Armand and Hosler, Betsy A. and Cortelli, Pietro and de Jong, Pieter J. and Yoshinaga, Yuko and Haines, Jonathan L. and Pericak‐Vance, Margaret A. and Yan, Jianing and Ticozzi, Nicola and Siddique, Teepu and McKenna‐Yasek, D. and Sapp, Peter C. and Horvitz, Howard Robert and Landers, John E. and Brown, Robert H.},
  title   = {{Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis}},
  journal = {Science},
  year    = {2009},
  doi     = {10.1126/science.1166066},
  pmid    = {19251627},
  url     = {https://doi.org/10.1126/science.1166066}
}

@article{vance2009-19251628,
  author  = {Vance, Caroline A. and Rogelj, Boris and Hortobágyi, Tibor and De Vos, Kurt J. and Nishimura, Agnes Lumi and Sreedharan, Jemeen and Hu, Xun and Smith, Bradley N. and Ruddy, Deborah and Wright, Paul D. and Ganesalingam, Jeban and Williams, Kelly L. and Tripathi, Vineeta and Al‐Saraj, Safa and Al‐Chalabi, Ammar and Leigh, P. Nigel and Blair, Ian P. and Nicholson, Garth A. and de Belleroche, Jackie and Gallo, Jean‐Marc and Miller, Christopher C.J. and Shaw, Christopher E.},
  title   = {{Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6}},
  journal = {Science},
  year    = {2009},
  doi     = {10.1126/science.1165942},
  pmid    = {19251628},
  url     = {https://doi.org/10.1126/science.1165942}
}

@article{campion1999-10441572,
  author  = {Campion, D. and Dumanchin, C. and Hannequin, D. and Dubois, B. and Belliard, S. and Puel, M. and Thomas-Anterion, C. and Michon, A. and others},
  title   = {{Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum}},
  journal = {American journal of human genetics},
  year    = {1999},
  doi     = {10.1086/302553},
  pmid    = {10441572},
  url     = {https://doi.org/10.1086/302553}
}

@article{zetterberg2008-18695061,
  author  = {Zetterberg, H. and Andreasson, U. and Hansson, O. and Wu, G. and Sankaranarayanan, S. and Andersson, M. E. and Buchhave, P. and Londos, E. and others},
  title   = {{Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.8.1102},
  pmid    = {18695061},
  url     = {https://doi.org/10.1001/archneur.65.8.1102}
}

@article{chan2015-26414614,
  author  = {Chan, G. and White, C. C. and Winn, P. A. and Cimpean, M. and Replogle, J. M. and Glick, L. R. and Cuerdon, N. E. and Ryan, K. J. and others},
  title   = {{CD33 modulates TREM2: convergence of Alzheimer loci}},
  journal = {Nature neuroscience},
  year    = {2015},
  doi     = {10.1038/nn.4126},
  pmid    = {26414614},
  url     = {https://doi.org/10.1038/nn.4126}
}

@article{levylahad1995-7638622,
  author  = {Levy‐Lahad, Ephrat and Wasco, Wilma and Poorkaj, Parvoneh and Romano, Donna and Oshima, Junko and Pettingell, Warren H. and Yu, Chang‐En and Jondro, P. D. and Schmidt, Stephen D. and Wang, Kai You and Crowley, Annette C. and Fu, Ying‐Hui and Guénette, Suzanne Y. and Galas, David J. and Nemens, Ellen J. and Wijsman, Ellen Marie and Bird, Thomas D. and Schellenberg, Gerard D. and Tanzi, Rudolph E.},
  title   = {{Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus}},
  journal = {Science},
  year    = {1995},
  doi     = {10.1126/science.7638622},
  pmid    = {7638622},
  url     = {https://doi.org/10.1126/science.7638622}
}

@article{games1995-7845465,
  author  = {Games, D. and Adams, D. and Alessandrini, R. and Barbour, R. and Berthelette, P. and Blackwell, C. and Carr, T. and Clemens, J. and others},
  title   = {{Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein}},
  journal = {Nature},
  year    = {1995},
  doi     = {10.1038/373523a0},
  pmid    = {7845465},
  url     = {https://doi.org/10.1038/373523a0}
}

@article{willem2015-26322584,
  author  = {Willem, M. and Tahirovic, S. and Busche, M. A. and Ovsepian, S. V. and Chafai, M. and Kootar, S. and Hornburg, D. and Evans, L. D. and others},
  title   = {{η-Secretase processing of APP inhibits neuronal activity in the hippocampus}},
  journal = {Nature},
  year    = {2015},
  doi     = {10.1038/nature14864},
  pmid    = {26322584},
  url     = {https://doi.org/10.1038/nature14864}
}

@article{delafuentearrillaga2025-40882668,
  author  = {de la Fuente‐Arrillaga, Carmen and Carlos, Silvia and Toledo, Estefanía and Barbería-Latasa, María and Razquín, Cristina and Ruiz‐Canela, Miguel and Gea, Alfredo and Martínez‐González, Miguel Ángel and others},
  title   = {{Cohort Profile Update: The ‘Seguimiento Universidad de Navarra’ (SUN) study after 24 years of follow-up}},
  journal = {International Journal of Epidemiology},
  year    = {2025},
  doi     = {10.1093/ije/dyaf149},
  pmid    = {40882668},
  url     = {https://doi.org/10.1093/ije/dyaf149}
}

@article{scheuner1996-8705854,
  author  = {Scheuner, Donalyn and Eckman, Christopher B. and Jensen, M. and Song, X.H. and Citron, Martin and Suzuki, Nobuhiro and Bird, Thomas D. and Hardy, John and Hutton, Melanie L. and Kukull, Walter A. and Larson, Eric B. and Levy‐Lahad, Ephrat and Viitanen, Matti H. and Peskind, Elaine R. and Poorkaj, Parvoneh and Schellenberg, Gerald D. and Tanzi, Rudolph E. and Wasco, Wilma and Lannfelt, Lars and Selkoe, Dennis J. and Younkin, Samuel G.},
  title   = {{Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease}},
  journal = {Nature Medicine},
  year    = {1996},
  doi     = {10.1038/nm0896-864},
  pmid    = {8705854},
  url     = {https://doi.org/10.1038/nm0896-864}
}

@article{polymeropoulos1997-9197268,
  author  = {Polymeropoulos, Mihael H. and Lavedan, Christian N. and Leroy, Elisabeth and Ide, Susan E. and Dehejia, Anindya M. and Dutra, Amalia and Pike, Brian L. and Root, Holly and Rubenstein, Jeffrey and Boyer, Rebecca and Stenroos, Edward S. and Chandrasekharappa, Settara C. and Athanassiadou, Aglaia and Papapetropoulos, Theodore and Johnson, William G. and Lazzarini, Alice M. and Duvoisin, Roger C. and Di Iorio, Giuseppe and Golbe, Lawrence I. and Nussbaum, Robert L.},
  title   = {{Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease}},
  journal = {Science},
  year    = {1997},
  doi     = {10.1126/science.276.5321.2045},
  pmid    = {9197268},
  url     = {https://doi.org/10.1126/science.276.5321.2045}
}

@article{griciuc2013-23623698,
  author  = {Griciuc, Ana and Serrano‐Pozo, Alberto and Parrado, Antonio and Lesinski, Andrea N. and Asselin, Caroline and Mullin, Kristina and Hooli, Basavaraj V. and Choi, Se Hoon and Hyman, Bradley T. and Tanzi, Rudolph E.},
  title   = {{Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta}},
  journal = {Neuron},
  year    = {2013},
  doi     = {10.1016/j.neuron.2013.04.014},
  pmid    = {23623698},
  url     = {https://doi.org/10.1016/j.neuron.2013.04.014}
}

@article{rogaev1995-7651536,
  author  = {Rogaev, Evgeny Ivanovich and Sherrington, Robin P. and Rogaeva, Ekaterina A. and Lévesque, Georges and Ikeda, Masaki and Liang, Yuh‐Jin and Chi, H. and Lin, Chen-Xi and Holman, K. and Tsuda, Takuya and Mar, Lynn and Sorbi, Sandro and Nacmias, Benedetta and Piacentini, Silvia and Amaducci, L. A. and Chumakov, Ilya M. and Cohen, Daniel Blair and Lannfelt, Lars and Fraser, Paul E. and Rommens, Johanna M. and George‐Hyslop, Peter St},
  title   = {{Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene}},
  journal = {Nature},
  year    = {1995},
  doi     = {10.1038/376775a0},
  pmid    = {7651536},
  url     = {https://doi.org/10.1038/376775a0}
}

@article{wolfe1999-10206644,
  author  = {Wolfe, Michael S. and Xia, Weiming and Ostaszewski, Beth L. and Diehl, Thekla S. and Kimberly, William Taylor and Selkoe, Dennis J.},
  title   = {{Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity}},
  journal = {Nature},
  year    = {1999},
  doi     = {10.1038/19077},
  pmid    = {10206644},
  url     = {https://doi.org/10.1038/19077}
}

@article{holcomb1998-9427614,
  author  = {Holcomb, L. and Gordon, M. N. and McGowan, E. and Yu, X. and Benkovic, S. and Jantzen, P. and Wright, K. and Saad, I. and others},
  title   = {{Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes}},
  journal = {Nature medicine},
  year    = {1998},
  doi     = {10.1038/nm0198-097},
  pmid    = {9427614},
  url     = {https://doi.org/10.1038/nm0198-097}
}

@article{pickford2008-18497889,
  author  = {Pickford, F. and Masliah, E. and Britschgi, M. and Lucin, K. and Narasimhan, R. and Jaeger, P. A. and Small, S. and Spencer, B. and others},
  title   = {{The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci33585},
  pmid    = {18497889},
  url     = {https://doi.org/10.1172/jci33585}
}

@article{bateman2006-16799555,
  author  = {Bateman, R. J. and Munsell, L. Y. and Morris, J. C. and Swarm, R. and Yarasheski, K. E. and Holtzman, D. M.},
  title   = {{Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo}},
  journal = {Nature medicine},
  year    = {2006},
  doi     = {10.1038/nm1438},
  pmid    = {16799555},
  url     = {https://doi.org/10.1038/nm1438}
}

@article{guo2013-23314060,
  author  = {Guo, L. H. and Alexopoulos, P. and Wagenpfeil, S. and Kurz, A. and Perneczky, R. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Plasma proteomics for the identification of Alzheimer disease}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2013},
  doi     = {10.1097/wad.0b013e31827b60d2},
  pmid    = {23314060},
  url     = {https://doi.org/10.1097/wad.0b013e31827b60d2}
}

@article{chouraki2014-24535457,
  author  = {Chouraki, V. and De Bruijn, R. F. and Chapuis, J. and Bis, J. C. and Reitz, C. and Schraen, S. and Ibrahim-Verbaas, C. A. and Grenier-Boley, B. and others},
  title   = {{A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly}},
  journal = {Molecular psychiatry},
  year    = {2014},
  doi     = {10.1038/mp.2013.185},
  pmid    = {24535457},
  url     = {https://doi.org/10.1038/mp.2013.185}
}

@article{kim2009-19679070,
  author  = {Kim, Jungsu and Basak, Jacob M. and Holtzman, David M.},
  title   = {{The Role of Apolipoprotein E in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2009},
  doi     = {10.1016/j.neuron.2009.06.026},
  pmid    = {19679070},
  url     = {https://doi.org/10.1016/j.neuron.2009.06.026}
}

@article{citron1992-1465129,
  author  = {Citron, Martin and Oltersdorf, Tilman and Haass, Christian and McConlogue, Lisa and Hung, Albert Y. and Seubert, Peter A. and Vigo‐Pelfrey, Carmen and Lieberburg, Ivan M. and Selkoe, Dennis J.},
  title   = {{Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production}},
  journal = {Nature},
  year    = {1992},
  doi     = {10.1038/360672a0},
  pmid    = {1465129},
  url     = {https://doi.org/10.1038/360672a0}
}

@article{schenk1999-10408445,
  author  = {Schenk, D. and Barbour, R. and Dunn, W. and Gordon, G. and Grajeda, H. and Guido, T. and Hu, K. and Huang, J. and others},
  title   = {{Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse}},
  journal = {Nature},
  year    = {1999},
  doi     = {10.1038/22124},
  pmid    = {10408445},
  url     = {https://doi.org/10.1038/22124}
}

@article{liu2025-39903689,
  author  = {Liu, Haiyan and Marsh, Thomas W. and Shi, Xinyu and Renton, Alan Edward and Bowling, Kevin M. and Ziegemeier, Ellen and Wang, Guoqiao and Cao, Yuchen and others},
  title   = {{The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awaf038},
  pmid    = {39903689},
  url     = {https://doi.org/10.1093/brain/awaf038}
}

@article{tanaka2026-41587040,
  author  = {Tanaka, Hidetomo and Black, Lauren Elaine and Forrest, Shelley L. and Danics, Krisztina and Sadia, Nusrat and Khodadadi, Mozhgan and Tator, Charles and Smith, Douglas H. and others},
  title   = {{Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy}},
  journal = {JAMA Neurology},
  year    = {2026},
  doi     = {10.1001/jamaneurol.2025.5421},
  pmid    = {41587040},
  url     = {https://doi.org/10.1001/jamaneurol.2025.5421}
}

@article{seyour2026-42139451,
  author  = {Seyour, Mohamed and Berger‐Estilita, Joana and Gisselbaek, Mia and Rubulotta, Francesca and Saxena, Sarah},
  title   = {{Sex-Based Differences in Perioperative Brain Health Outcomes}},
  journal = {A\&A Practice},
  year    = {2026},
  doi     = {10.1213/xaa.0000000000002200},
  pmid    = {42139451},
  url     = {https://doi.org/10.1213/xaa.0000000000002200}
}

@article{zhang2024-39363202,
  author  = {Zhang, X. X. and Wei, M. and Wang, H. R. and Hu, Y. Z. and Sun, H. M. and Jia, J. J.},
  title   = {{Mitochondrial dysfunction gene expression, DNA methylation, and inflammatory cytokines interaction activate Alzheimer's disease: a multi-omics Mendelian randomization study}},
  journal = {Journal of translational medicine},
  year    = {2024},
  doi     = {10.1186/s12967-024-05680-z},
  pmid    = {39363202},
  url     = {https://doi.org/10.1186/s12967-024-05680-z}
}

@article{kabashi2008-18372902,
  author  = {Kabashi, Edor and Valdmanis, Paul N. and Dion, Patrick A. and Spiegelman, Dan and McConkey, Brendan J. and Velde, Christine Vande and Bouchard, Jean‐Pierre and Lacomblez, Lucette and Pochigaeva, Ksenia and Salachas, François and Pradat, Pierre‐François and Camu, William and Meininger, Vincent and Dupré, Nicolas and Rouleau, Guy Armand},
  title   = {{TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis}},
  journal = {Nature Genetics},
  year    = {2008},
  doi     = {10.1038/ng.132},
  pmid    = {18372902},
  url     = {https://doi.org/10.1038/ng.132}
}

@article{tanzi1988-2893290,
  author  = {Tanzi, Rudolph E. and McClatchey, Andrea I. and Lamperti, Edward D. and Villa‐Komaroff, Lydia and Gusella, James F. and Neve, Rachael L.},
  title   = {{Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease}},
  journal = {Nature},
  year    = {1988},
  doi     = {10.1038/331528a0},
  pmid    = {2893290},
  url     = {https://doi.org/10.1038/331528a0}
}

@article{lohmann2012-22503161,
  author  = {Lohmann, Ebba and Guerreiro, Rita J and Erginel-Unaltuna, Nihan and Gurunlian, Nicole and Bilgic, Basar and Gurvit, Hakan and Hanagasi, Hasmet A and Luu, Nga and others},
  title   = {{Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2012.02.020},
  pmid    = {22503161},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2012.02.020}
}

@article{ehehalt2003-12515826,
  author  = {Ehehalt, R. and Keller, P. and Haass, C. and Thiele, C. and Simons, K.},
  title   = {{Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts}},
  journal = {The Journal of cell biology},
  year    = {2003},
  doi     = {10.1083/jcb.200207113},
  pmid    = {12515826},
  url     = {https://doi.org/10.1083/jcb.200207113}
}

@article{areagomez2012-22892566,
  author  = {Area-Gomez, E. and Del Carmen Lara Castillo, M. and Tambini, M. D. and Guardia-Laguarta, C. and de Groof, A. J. and Madra, M. and Ikenouchi, J. and Umeda, M. and others},
  title   = {{Upregulated function of mitochondria-associated ER membranes in Alzheimer disease}},
  journal = {The EMBO journal},
  year    = {2012},
  doi     = {10.1038/emboj.2012.202},
  pmid    = {22892566},
  url     = {https://doi.org/10.1038/emboj.2012.202}
}

@article{town2008-18516051,
  author  = {Town, T. and Laouar, Y. and Pittenger, C. and Mori, T. and Szekely, C. A. and Tan, J. and Duman, R. S. and Flavell, R. A.},
  title   = {{Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology}},
  journal = {Nature medicine},
  year    = {2008},
  doi     = {10.1038/nm1781},
  pmid    = {18516051},
  url     = {https://doi.org/10.1038/nm1781}
}

@article{cisse2011-21113149,
  author  = {Cissé, M. and Halabisky, B. and Harris, J. and Devidze, N. and Dubal, D. B. and Sun, B. and Orr, A. and Lotz, G. and others},
  title   = {{Reversing EphB2 depletion rescues cognitive functions in Alzheimer model}},
  journal = {Nature},
  year    = {2011},
  doi     = {10.1038/nature09635},
  pmid    = {21113149},
  url     = {https://doi.org/10.1038/nature09635}
}

@article{cady2014-24535663,
  author  = {Cady, J. and Koval, E. D. and Benitez, B. A. and Zaidman, C. and Jockel-Balsarotti, J. and Allred, P. and Baloh, R. H. and Ravits, J. and others},
  title   = {{TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.6237},
  pmid    = {24535663},
  url     = {https://doi.org/10.1001/jamaneurol.2013.6237}
}

@article{fleisher2015-25580592,
  author  = {Fleisher, A. S. and Chen, K. and Quiroz, Y. T. and Jakimovich, L. J. and Gutierrez Gomez, M. and Langois, C. M. and Langbaum, J. B. and Roontiva, A. and others},
  title   = {{Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.3314},
  pmid    = {25580592},
  url     = {https://doi.org/10.1001/jamaneurol.2014.3314}
}

@article{harms2013-23588422,
  author  = {Harms, M. and Benitez, B. A. and Cairns, N. and Cooper, B. and Cooper, P. and Mayo, K. and Carrell, D. and Faber, K. and others},
  title   = {{C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/2013.jamaneurol.537},
  pmid    = {23588422},
  url     = {https://doi.org/10.1001/2013.jamaneurol.537}
}

@article{zarea2016-27466472,
  author  = {Zarea, A. and Charbonnier, C. and Rovelet-Lecrux, A. and Nicolas, G. and Rousseau, S. and Borden, A. and Pariente, J. and Le Ber, I. and others},
  title   = {{Seizures in dominantly inherited Alzheimer disease}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000003048},
  pmid    = {27466472},
  url     = {https://doi.org/10.1212/wnl.0000000000003048}
}

@article{baker2003-12611754,
  author  = {Baker, L. D. and Sambamurti, K. and Craft, S. and Cherrier, M. and Raskind, M. A. and Stanczyk, F. Z. and Plymate, SR. and Asthana, S.},
  title   = {{17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2003},
  doi     = {10.1097/00019442-200303000-00015},
  pmid    = {12611754},
  url     = {https://doi.org/10.1097/00019442-200303000-00015}
}

@article{goldgaber1987-3810169,
  author  = {Goldgaber, Dmitry and Lerman, Michael I. and McBride, O. Wesley and Saffiotti, Umberto and Gajdusek, D. Carleton},
  title   = {{Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease}},
  journal = {Science},
  year    = {1987},
  doi     = {10.1126/science.3810169},
  pmid    = {3810169},
  url     = {https://doi.org/10.1126/science.3810169}
}

@article{levy1990-2111584,
  author  = {Levy, Efrat and Carman, M. D. and Fernandez-Madrid, Ivan J. and Power, Michael D. and Lieberburg, Ivan M. and van Duinen, Sjoerd G. and Bots, Gerard Th. A. M. and Luyendijk, W and Frangione, Blas},
  title   = {{Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type}},
  journal = {Science},
  year    = {1990},
  doi     = {10.1126/science.2111584},
  pmid    = {2111584},
  url     = {https://doi.org/10.1126/science.2111584}
}

@article{bloom2014-24493463,
  author  = {Bloom, G. S.},
  title   = {{Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.5847},
  pmid    = {24493463},
  url     = {https://doi.org/10.1001/jamaneurol.2013.5847}
}

@article{bard2000-10932230,
  author  = {Bard, F. and Cannon, C. and Barbour, R. and Burke, R. L. and Games, D. and Grajeda, H. and Guido, T. and Hu, K. and others},
  title   = {{Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease}},
  journal = {Nature medicine},
  year    = {2000},
  doi     = {10.1038/78682},
  pmid    = {10932230},
  url     = {https://doi.org/10.1038/78682}
}

@article{verret2012-22541439,
  author  = {Verret, L. and Mann, E. O. and Hang, G. B. and Barth, A. M. and Cobos, I. and Ho, K. and Devidze, N. and Masliah, E. and others},
  title   = {{Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model}},
  journal = {Cell},
  year    = {2012},
  doi     = {10.1016/j.cell.2012.02.046},
  pmid    = {22541439},
  url     = {https://doi.org/10.1016/j.cell.2012.02.046}
}

@article{thinakaran2008-18650430,
  author  = {Thinakaran, G. and Koo, E. H.},
  title   = {{Amyloid precursor protein trafficking, processing, and function}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.r800019200},
  pmid    = {18650430},
  url     = {https://doi.org/10.1074/jbc.r800019200}
}

@article{nitsch1992-1411529,
  author  = {Nitsch, R. M. and Slack, B. E. and Wurtman, R. J. and Growdon, J. H.},
  title   = {{Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors}},
  journal = {Science (New York, N.Y.)},
  year    = {1992},
  doi     = {10.1126/science.1411529},
  pmid    = {1411529},
  url     = {https://doi.org/10.1126/science.1411529}
}

@article{hartmann1997-9288729,
  author  = {Hartmann, T. and Bieger, S. C. and Brühl, B. and Tienari, P. J. and Ida, N. and Allsop, D. and Roberts, G. W. and Masters, C. L. and others},
  title   = {{Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides}},
  journal = {Nature medicine},
  year    = {1997},
  doi     = {10.1038/nm0997-1016},
  pmid    = {9288729},
  url     = {https://doi.org/10.1038/nm0997-1016}
}

@article{wysscoray2001-11329064,
  author  = {Wyss-Coray, T. and Lin, C. and Yan, F. and Yu, G. Q. and Rohde, M. and McConlogue, L. and Masliah, E. and Mucke, L.},
  title   = {{TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice}},
  journal = {Nature medicine},
  year    = {2001},
  doi     = {10.1038/87945},
  pmid    = {11329064},
  url     = {https://doi.org/10.1038/87945}
}

@article{chavezgutierrez2012-22505025,
  author  = {Chávez-Gutiérrez, L. and Bammens, L. and Benilova, I. and Vandersteen, A. and Benurwar, M. and Borgers, M. and Lismont, S. and Zhou, L. and others},
  title   = {{The mechanism of γ-Secretase dysfunction in familial Alzheimer disease}},
  journal = {The EMBO journal},
  year    = {2012},
  doi     = {10.1038/emboj.2012.79},
  pmid    = {22505025},
  url     = {https://doi.org/10.1038/emboj.2012.79}
}

@article{suarezcalvet2016-27974666,
  author  = {Suárez-Calvet, M. and MÁ, Araque Caballero and Kleinberger, G. and Bateman, R. J. and Fagan, A. M. and Morris, J. C. and Levin, J. and Danek, A. and others},
  title   = {{Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury}},
  journal = {Science translational medicine},
  year    = {2016},
  doi     = {10.1126/scitranslmed.aag1767},
  pmid    = {27974666},
  url     = {https://doi.org/10.1126/scitranslmed.aag1767}
}

@article{korvatska2015-26076170,
  author  = {Korvatska, O. and Leverenz, J. B. and Jayadev, S. and McMillan, P. and Kurtz, I. and Guo, X. and Rumbaugh, M. and Matsushita, M. and others},
  title   = {{R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2015.0979},
  pmid    = {26076170},
  url     = {https://doi.org/10.1001/jamaneurol.2015.0979}
}

@article{pera2013-23224319,
  author  = {Pera, M. and Alcolea, D. and Sánchez-Valle, R. and Guardia-Laguarta, C. and Colom-Cadena, M. and Badiola, N. and Suárez-Calvet, M. and Lladó, A. and others},
  title   = {{Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease}},
  journal = {Acta neuropathologica},
  year    = {2013},
  doi     = {10.1007/s00401-012-1062-9},
  pmid    = {23224319},
  url     = {https://doi.org/10.1007/s00401-012-1062-9}
}

@article{hsu2021-33580635,
  author  = {Hsu, Jung-Lung and Lin, Chin-Hsien and Chen, Pei-Lung and Lin, Kun-Ju and Chen, Ta-Fu},
  title   = {{Genetic study of young-onset dementia using targeted gene panel sequencing in Taiwan}},
  journal = {American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year    = {2021},
  doi     = {10.1002/ajmg.b.32836},
  pmid    = {33580635},
  url     = {https://doi.org/10.1002/ajmg.b.32836}
}

@article{castillobarnes2020-32284705,
  author  = {Castillo-Barnes, Diego and Su, Li and Ramírez, Javier and Salas-Gonzalez, Diego and Martinez-Murcia, Francisco J and Illan, Ignacio A and Segovia, Fermin and Ortiz, Andres and others},
  title   = {{Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning}},
  journal = {An international journal on information fusion},
  year    = {2020},
  doi     = {10.1016/j.inffus.2020.01.001},
  pmid    = {32284705},
  url     = {https://doi.org/10.1016/j.inffus.2020.01.001}
}

@article{hoogmartens2021-33023779,
  author  = {Hoogmartens, Julie and Hens, Elisabeth and Engelborghs, Sebastiaan and Vandenberghe, Rik and De Deyn, Peter-P and Cacace, Rita and Van Broeckhoven, Christine and {BELNEU Consortium}},
  title   = {{Contribution of homozygous and compound heterozygous missense mutations in VWA2 to Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2020.09.009},
  pmid    = {33023779},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2020.09.009}
}

@article{ulland2018-30266932,
  author  = {Ulland, T. K. and Colonna, M.},
  title   = {{TREM2 - a key player in microglial biology and Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2018},
  doi     = {10.1038/s41582-018-0072-1},
  pmid    = {30266932},
  url     = {https://doi.org/10.1038/s41582-018-0072-1}
}

@article{lemere1996-8837617,
  author  = {Lemere, C. A. and Lopera, F. and Kosik, K. S. and Lendon, C. L. and Ossa, J. and Saido, T. C. and Yamaguchi, H. and Ruiz, A. and others},
  title   = {{The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology}},
  journal = {Nature medicine},
  year    = {1996},
  doi     = {10.1038/nm1096-1146},
  pmid    = {8837617},
  url     = {https://doi.org/10.1038/nm1096-1146}
}

@article{prasher1998-9506555,
  author  = {Prasher, V. P. and Farrer, M. J. and Kessling, A. M. and Fisher, E. M. and West, R. J. and Barber, P. C. and Butler, A. C.},
  title   = {{Molecular mapping of Alzheimer-type dementia in Down's syndrome}},
  journal = {Annals of neurology},
  year    = {1998},
  doi     = {10.1002/ana.410430316},
  pmid    = {9506555},
  url     = {https://doi.org/10.1002/ana.410430316}
}

@article{podlesniy2013-23794434,
  author  = {Podlesniy, P. and Figueiro-Silva, J. and Llado, A. and Antonell, A. and Sanchez-Valle, R. and Alcolea, D. and Lleo, A. and Molinuevo, J. L. and others},
  title   = {{Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23955},
  pmid    = {23794434},
  url     = {https://doi.org/10.1002/ana.23955}
}

@article{ringman2008-18509095,
  author  = {Ringman, J. M. and Younkin, S. G. and Pratico, D. and Seltzer, W. and Cole, G. M. and Geschwind, D. H. and Rodriguez-Agudelo, Y. and Schaffer, B. and others},
  title   = {{Biochemical markers in persons with preclinical familial Alzheimer disease}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000303973.71803.81},
  pmid    = {18509095},
  url     = {https://doi.org/10.1212/01.wnl.0000303973.71803.81}
}

@article{wang2016-26611835,
  author  = {Wang, Z. and Lei, H. and Zheng, M. and Li, Y. and Cui, Y. and Hao, F.},
  title   = {{Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1}},
  journal = {Molecular neurobiology},
  year    = {2016},
  doi     = {10.1007/s12035-015-9546-y},
  pmid    = {26611835},
  url     = {https://doi.org/10.1007/s12035-015-9546-y}
}

@article{mullan1992-1302033,
  author  = {Mullan, Mike and Crawford, Fiona and Axelman, Karin and Houlden, Henry and Lilius, Lena and Winblad, Bengt G. and Lannfelt, Lars},
  title   = {{A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid}},
  journal = {Nature Genetics},
  year    = {1992},
  doi     = {10.1038/ng0892-345},
  pmid    = {1302033},
  url     = {https://doi.org/10.1038/ng0892-345}
}

@article{suzuki1994-8191290,
  author  = {Suzuki, Nobuhiro and Cheung, Tobun T. and Cai, Xiao-Dan and Odaka, Asano and Ötvös, László and Eckman, Christopher B. and Golde, Todd Eliot and Younkin, Steven G.},
  title   = {{An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants}},
  journal = {Science},
  year    = {1994},
  doi     = {10.1126/science.8191290},
  pmid    = {8191290},
  url     = {https://doi.org/10.1126/science.8191290}
}

@article{novotny2023-36251323,
  author  = {Novotny, Brenna C and Fernandez, Maria Victoria and Wang, Ciyang and Budde, John P and Bergmann, Kristy and Eteleeb, Abdallah M and Bradley, Joseph and Webster, Carol and others},
  title   = {{Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.12800},
  pmid    = {36251323},
  url     = {https://doi.org/10.1002/alz.12800}
}

@article{borchelt1997-9354339,
  author  = {Borchelt, D. R. and Ratovitski, T. and van Lare, J. and Lee, M. K. and Gonzales, V. and Jenkins, N. A. and Copeland, N. G. and Price, D. L. and others},
  title   = {{Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins}},
  journal = {Neuron},
  year    = {1997},
  doi     = {10.1016/s0896-6273(00)80974-5},
  pmid    = {9354339},
  url     = {https://doi.org/10.1016/s0896-6273(00)80974-5}
}

@article{bekris2010-21045163,
  author  = {Bekris, L. M. and Yu, C. E. and Bird, T. D. and Tsuang, D. W.},
  title   = {{Genetics of Alzheimer disease}},
  journal = {Journal of geriatric psychiatry and neurology},
  year    = {2010},
  doi     = {10.1177/0891988710383571},
  pmid    = {21045163},
  url     = {https://doi.org/10.1177/0891988710383571}
}

@article{leissring2003-14687544,
  author  = {Leissring, M. A. and Farris, W. and Chang, A. Y. and Walsh, D. M. and Wu, X. and Sun, X. and Frosch, M. P. and Selkoe, D. J.},
  title   = {{Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00787-6},
  pmid    = {14687544},
  url     = {https://doi.org/10.1016/s0896-6273(03)00787-6}
}

@article{muller2017-28360418,
  author  = {Müller, U. C. and Deller, T. and Korte, M.},
  title   = {{Not just amyloid: physiological functions of the amyloid precursor protein family}},
  journal = {Nature reviews. Neuroscience},
  year    = {2017},
  doi     = {10.1038/nrn.2017.29},
  pmid    = {28360418},
  url     = {https://doi.org/10.1038/nrn.2017.29}
}

@article{roberts1994-8163989,
  author  = {Roberts, G. W. and Gentleman, S. M. and Lynch, A. and Murray, L. and Landon, M. and Graham, D. I.},
  title   = {{Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {1994},
  doi     = {10.1136/jnnp.57.4.419},
  pmid    = {8163989},
  url     = {https://doi.org/10.1136/jnnp.57.4.419}
}

@article{lee1998-9623986,
  author  = {Lee, S. J. and Liyanage, U. and Bickel, P. E. and Xia, W. and Lansbury, P. T. and Kosik, K. S.},
  title   = {{A detergent-insoluble membrane compartment contains A beta in vivo}},
  journal = {Nature medicine},
  year    = {1998},
  doi     = {10.1038/nm0698-730},
  pmid    = {9623986},
  url     = {https://doi.org/10.1038/nm0698-730}
}

@article{wolozin1996-8939861,
  author  = {Wolozin, B. and Iwasaki, K. and Vito, P. and Ganjei, J. K. and Lacanà, E. and Sunderland, T. and Zhao, B. and Kusiak, J. W. and others},
  title   = {{Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation}},
  journal = {Science (New York, N.Y.)},
  year    = {1996},
  doi     = {10.1126/science.274.5293.1710},
  pmid    = {8939861},
  url     = {https://doi.org/10.1126/science.274.5293.1710}
}

@article{schlepckow2017-28855300,
  author  = {Schlepckow, K. and Kleinberger, G. and Fukumori, A. and Feederle, R. and Lichtenthaler, S. F. and Steiner, H. and Haass, C.},
  title   = {{An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201707672},
  pmid    = {28855300},
  url     = {https://doi.org/10.15252/emmm.201707672}
}

@article{gourmaud2020-31834353,
  author  = {Gourmaud, S. and Shou, H. and Irwin, D. J. and Sansalone, K. and Jacobs, L. M. and Lucas, T. H. and Marsh, E. D. and Davis, K. A. and others},
  title   = {{Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awz381},
  pmid    = {31834353},
  url     = {https://doi.org/10.1093/brain/awz381}
}

@article{delaguila2019-31068200,
  author  = {Del-Aguila, J. L. and Benitez, B. A. and Li, Z. and Dube, U. and Mihindukulasuriya, K. A. and Budde, J. P. and Farias, F. H. G. and Fernández, M. V. and others},
  title   = {{TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0319-3},
  pmid    = {31068200},
  url     = {https://doi.org/10.1186/s13024-019-0319-3}
}

@article{oliveiramonteiroepereiradealmeida2024-37460331,
  author  = {Oliveira Monteiro E Pereira de Almeida, M. P. and Valle Pedroso, R. and Mantellatto Grigoli, M. and Vicente Silva, T. and Manzine, P. R. and Cominetti, M. R.},
  title   = {{ADAM10 as a biomarker for Alzheimer's disease: A systematic review}},
  journal = {Revue neurologique},
  year    = {2024},
  doi     = {10.1016/j.neurol.2023.04.002},
  pmid    = {37460331},
  url     = {https://doi.org/10.1016/j.neurol.2023.04.002}
}

@article{sturchlerpierrat1997-9371838,
  author  = {Sturchler-Pierrat, C. and Abramowski, D. and Duke, M. and Wiederhold, K. H. and Mistl, C. and Rothacher, S. and Ledermann, B. and Bürki, K. and others},
  title   = {{Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.24.13287},
  pmid    = {9371838},
  url     = {https://doi.org/10.1073/pnas.94.24.13287}
}

@article{haass2012-22553493,
  author  = {Haass, C. and Kaether, C. and Thinakaran, G. and Sisodia, S.},
  title   = {{Trafficking and proteolytic processing of APP}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
  doi     = {10.1101/cshperspect.a006270},
  pmid    = {22553493},
  url     = {https://doi.org/10.1101/cshperspect.a006270}
}

@article{qin2006-16751189,
  author  = {Qin, W. and Yang, T. and Ho, L. and Zhao, Z. and Wang, J. and Chen, L. and Zhao, W. and Thiyagarajan, M. and others},
  title   = {{Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m602909200},
  pmid    = {16751189},
  url     = {https://doi.org/10.1074/jbc.m602909200}
}

@article{sisodia1992-1631093,
  author  = {Sisodia, S. S.},
  title   = {{Beta-amyloid precursor protein cleavage by a membrane-bound protease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.13.6075},
  pmid    = {1631093},
  url     = {https://doi.org/10.1073/pnas.89.13.6075}
}

@article{rezaizadeh2005-16177050,
  author  = {Rezai-Zadeh, K. and Shytle, D. and Sun, N. and Mori, T. and Hou, H. and Jeanniton, D. and Ehrhart, J. and Townsend, K. and others},
  title   = {{Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.1521-05.2005},
  pmid    = {16177050},
  url     = {https://doi.org/10.1523/jneurosci.1521-05.2005}
}

@article{vassar2014-24646365,
  author  = {Vassar, R. and Kuhn, P. H. and Haass, C. and Kennedy, M. E. and Rajendran, L. and Wong, P. C. and Lichtenthaler, S. F.},
  title   = {{Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects}},
  journal = {Journal of neurochemistry},
  year    = {2014},
  doi     = {10.1111/jnc.12715},
  pmid    = {24646365},
  url     = {https://doi.org/10.1111/jnc.12715}
}

@article{esparza2013-23225543,
  author  = {Esparza, T. J. and Zhao, H. and Cirrito, JR. and Cairns, N. J. and Bateman, R. J. and Holtzman, D. M. and Brody, D. L.},
  title   = {{Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23748},
  pmid    = {23225543},
  url     = {https://doi.org/10.1002/ana.23748}
}

@article{pottier2012-22472873,
  author  = {Pottier, C. and Hannequin, D. and Coutant, S. and Rovelet-Lecrux, A. and Wallon, D. and Rousseau, S. and Legallic, S. and Paquet, C. and others},
  title   = {{High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease}},
  journal = {Molecular psychiatry},
  year    = {2012},
  doi     = {10.1038/mp.2012.15},
  pmid    = {22472873},
  url     = {https://doi.org/10.1038/mp.2012.15}
}

@article{park2017-28515043,
  author  = {Park, L. and Uekawa, K. and Garcia-Bonilla, L. and Koizumi, K. and Murphy, M. and Pistik, R. and Younkin, L. and Younkin, S. and others},
  title   = {{Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides}},
  journal = {Circulation research},
  year    = {2017},
  doi     = {10.1161/circresaha.117.311054},
  pmid    = {28515043},
  url     = {https://doi.org/10.1161/circresaha.117.311054}
}

@article{suberbielle2015-26615780,
  author  = {Suberbielle, E. and Djukic, B. and Evans, M. and Kim, D. H. and Taneja, P. and Wang, X. and Finucane, M. and Knox, J. and others},
  title   = {{DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice}},
  journal = {Nature communications},
  year    = {2015},
  doi     = {10.1038/ncomms9897},
  pmid    = {26615780},
  url     = {https://doi.org/10.1038/ncomms9897}
}

@article{vardarajan2015-25382023,
  author  = {Vardarajan, B. N. and Zhang, Y. and Lee, J. H. and Cheng, R. and Bohm, C. and Ghani, M. and Reitz, C. and Reyes-Dumeyer, D. and others},
  title   = {{Coding mutations in SORL1 and Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24305},
  pmid    = {25382023},
  url     = {https://doi.org/10.1002/ana.24305}
}

@article{jaeger2010-20559548,
  author  = {Jaeger, P. A. and Pickford, F. and Sun, C. H. and Lucin, K. M. and Masliah, E. and Wyss-Coray, T.},
  title   = {{Regulation of amyloid precursor protein processing by the Beclin 1 complex}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0011102},
  pmid    = {20559548},
  url     = {https://doi.org/10.1371/journal.pone.0011102}
}

@article{schultz2023-37291760,
  author  = {Schultz, S. A. and Shirzadi, Z. and Schultz, A. P. and Liu, L. and Fitzpatrick, C. D. and McDade, E. and Barthelemy, N. R. and Renton, A. and others},
  title   = {{Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease}},
  journal = {Aging cell},
  year    = {2023},
  doi     = {10.1111/acel.13871},
  pmid    = {37291760},
  url     = {https://doi.org/10.1111/acel.13871}
}

@article{liu2022-36306459,
  author  = {Liu, Cuicui and Cong, Lin and Zhu, Min and Wang, Yongxiang and Tang, Shi and Han, Xiaojuan and Zhang, Qinghua and Tian, Na and others},
  title   = {{Screening for Genetic Mutations Associated with Early-Onset Alzheimer's Disease in Han Chinese}},
  journal = {Current Alzheimer research},
  year    = {2022},
  doi     = {10.2174/1567205020666221028112915},
  pmid    = {36306459},
  url     = {https://doi.org/10.2174/1567205020666221028112915}
}

@article{wang2008-19050078,
  author  = {Wang, X. and Su, B. and Siedlak, S. L. and Moreira, P. I. and Fujioka, H. and Wang, Y. and Casadesus, G. and Zhu, X.},
  title   = {{Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2008},
  doi     = {10.1073/pnas.0804871105},
  pmid    = {19050078},
  url     = {https://doi.org/10.1073/pnas.0804871105}
}

@article{blurtonjones2009-19633196,
  author  = {Blurton-Jones, M. and Kitazawa, M. and Martinez-Coria, H. and Castello, N. A. and Müller, F. J. and Loring, J. F. and Yamasaki, T. R. and Poon, W. W. and others},
  title   = {{Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0901402106},
  pmid    = {19633196},
  url     = {https://doi.org/10.1073/pnas.0901402106}
}

@article{destrooper2010-20139999,
  author  = {De Strooper, B. and Vassar, R. and Golde, T.},
  title   = {{The secretases: enzymes with therapeutic potential in Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2010},
  doi     = {10.1038/nrneurol.2009.218},
  pmid    = {20139999},
  url     = {https://doi.org/10.1038/nrneurol.2009.218}
}

@article{greig2005-16275899,
  author  = {Greig, N. H. and Utsuki, T. and Ingram, D. K. and Wang, Y. and Pepeu, G. and Scali, C. and Yu, Q. S. and Mamczarz, J. and others},
  title   = {{Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0508575102},
  pmid    = {16275899},
  url     = {https://doi.org/10.1073/pnas.0508575102}
}

@article{cohen2013-23575824,
  author  = {Cohen, R. M. and Rezai-Zadeh, K. and Weitz, T. M. and Rentsendorj, A. and Gate, D. and Spivak, I. and Bholat, Y. and Vasilevko, V. and others},
  title   = {{A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2013},
  doi     = {10.1523/jneurosci.3672-12.2013},
  pmid    = {23575824},
  url     = {https://doi.org/10.1523/jneurosci.3672-12.2013}
}

@article{saito1993-8464868,
  author  = {Saito, K. and Elce, J. S. and Hamos, J. E. and Nixon, R. A.},
  title   = {{Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.7.2628},
  pmid    = {8464868},
  url     = {https://doi.org/10.1073/pnas.90.7.2628}
}

@article{singer2005-16136043,
  author  = {Singer, O. and Marr, R. A. and Rockenstein, E. and Crews, L. and Coufal, N. G. and Gage, F. H. and Verma, I. M. and Masliah, E.},
  title   = {{Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model}},
  journal = {Nature neuroscience},
  year    = {2005},
  doi     = {10.1038/nn1531},
  pmid    = {16136043},
  url     = {https://doi.org/10.1038/nn1531}
}

@article{kaufman2015-25707991,
  author  = {Kaufman, A. C. and Salazar, S. V. and Haas, L. T. and Yang, J. and Kostylev, M. A. and Jeng, A. T. and Robinson, S. A. and Gunther, E. C. and others},
  title   = {{Fyn inhibition rescues established memory and synapse loss in Alzheimer mice}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24394},
  pmid    = {25707991},
  url     = {https://doi.org/10.1002/ana.24394}
}

@article{xiang2018-30185230,
  author  = {Xiang, X. and Piers, T. M. and Wefers, B. and Zhu, K. and Mallach, A. and Brunner, B. and Kleinberger, G. and Song, W. and others},
  title   = {{The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0280-6},
  pmid    = {30185230},
  url     = {https://doi.org/10.1186/s13024-018-0280-6}
}

@article{mcdade2021-34548654,
  author  = {McDade, E. and Voytyuk, I. and Aisen, P. and Bateman, R. J. and Carrillo, M. C. and De Strooper, B. and Haass, C. and Reiman, E. M. and others},
  title   = {{The case for low-level BACE1 inhibition for the prevention of Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2021},
  doi     = {10.1038/s41582-021-00545-1},
  pmid    = {34548654},
  url     = {https://doi.org/10.1038/s41582-021-00545-1}
}

@article{cirrito2005-16239972,
  author  = {Cirrito, JR. and Deane, R. and Fagan, A. M. and Spinner, M. L. and Parsadanian, M. and Finn, M. B. and Jiang, H. and Prior, J. L. and others},
  title   = {{P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model}},
  journal = {The Journal of clinical investigation},
  year    = {2005},
  doi     = {10.1172/jci25247},
  pmid    = {16239972},
  url     = {https://doi.org/10.1172/jci25247}
}

@article{barger1997-9278049,
  author  = {Barger, S. W. and Harmon, A. D.},
  title   = {{Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E}},
  journal = {Nature},
  year    = {1997},
  doi     = {10.1038/42257},
  pmid    = {9278049},
  url     = {https://doi.org/10.1038/42257}
}

@article{dickson1997-9100663,
  author  = {Dickson, D. W.},
  title   = {{The pathogenesis of senile plaques}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1997},
  doi     = {10.1097/00005072-199704000-00001},
  pmid    = {9100663},
  url     = {https://doi.org/10.1097/00005072-199704000-00001}
}

@article{koo1990-1689489,
  author  = {Koo, E. H. and Sisodia, S. S. and Archer, D. R. and Martin, L. J. and Weidemann, A. and Beyreuther, K. and Fischer, P. and Masters, C. L. and others},
  title   = {{Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1990},
  doi     = {10.1073/pnas.87.4.1561},
  pmid    = {1689489},
  url     = {https://doi.org/10.1073/pnas.87.4.1561}
}

@article{postina2004-15146243,
  author  = {Postina, R. and Schroeder, A. and Dewachter, I. and Bohl, J. and Schmitt, U. and Kojro, E. and Prinzen, C. and Endres, K. and others},
  title   = {{A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model}},
  journal = {The Journal of clinical investigation},
  year    = {2004},
  doi     = {10.1172/jci20864},
  pmid    = {15146243},
  url     = {https://doi.org/10.1172/jci20864}
}

@article{ly2013-23202730,
  author  = {Ly, P. T. and Wu, Y. and Zou, H. and Wang, R. and Zhou, W. and Kinoshita, A. and Zhang, M. and Yang, Y. and others},
  title   = {{Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes}},
  journal = {The Journal of clinical investigation},
  year    = {2013},
  doi     = {10.1172/jci64516},
  pmid    = {23202730},
  url     = {https://doi.org/10.1172/jci64516}
}

@article{busciglio1993-8446635,
  author  = {Busciglio, J. and Gabuzda, D. H. and Matsudaira, P. and Yankner, B. A.},
  title   = {{Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.5.2092},
  pmid    = {8446635},
  url     = {https://doi.org/10.1073/pnas.90.5.2092}
}

@article{cheng2007-17548355,
  author  = {Cheng, I. H. and Scearce-Levie, K. and Legleiter, J. and Palop, J. J. and Gerstein, H. and Bien-Ly, N. and Puoliväli, J. and Lesné, S. and others},
  title   = {{Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m701078200},
  pmid    = {17548355},
  url     = {https://doi.org/10.1074/jbc.m701078200}
}

@article{tanzi2001-11683989,
  author  = {Tanzi, R. E. and Bertram, L.},
  title   = {{New frontiers in Alzheimer's disease genetics}},
  journal = {Neuron},
  year    = {2001},
  doi     = {10.1016/s0896-6273(01)00476-7},
  pmid    = {11683989},
  url     = {https://doi.org/10.1016/s0896-6273(01)00476-7}
}

@article{tomita1997-9050898,
  author  = {Tomita, T. and Maruyama, K. and Saido, T. C. and Kume, H. and Shinozaki, K. and Tokuhiro, S. and Capell, A. and Walter, J. and others},
  title   = {{The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.5.2025},
  pmid    = {9050898},
  url     = {https://doi.org/10.1073/pnas.94.5.2025}
}

@article{cruts1998-9384602,
  author  = {Cruts, M. and van Duijn, C. M. and Backhovens, H. and Van den Broeck, M. and Wehnert, A. and Serneels, S. and Sherrington, R. and Hutton, M. and others},
  title   = {{Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease}},
  journal = {Human molecular genetics},
  year    = {1998},
  doi     = {10.1093/hmg/7.1.43},
  pmid    = {9384602},
  url     = {https://doi.org/10.1093/hmg/7.1.43}
}

@article{hemming2005-16154999,
  author  = {Hemming, M. L. and Selkoe, D. J.},
  title   = {{Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508460200},
  pmid    = {16154999},
  url     = {https://doi.org/10.1074/jbc.m508460200}
}

@article{caporaso1992-1557413,
  author  = {Caporaso, G. L. and Gandy, S. E. and Buxbaum, J. D. and Ramabhadran, T. V. and Greengard, P.},
  title   = {{Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.7.3055},
  pmid    = {1557413},
  url     = {https://doi.org/10.1073/pnas.89.7.3055}
}

@article{sultana2006-15950321,
  author  = {Sultana, R. and Boyd-Kimball, D. and Poon, H. F. and Cai, J. and Pierce, W. M. and Klein, J. B. and Markesbery, W. R. and Zhou, X. Z. and others},
  title   = {{Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis}},
  journal = {Neurobiology of aging},
  year    = {2006},
  doi     = {10.1016/j.neurobiolaging.2005.05.005},
  pmid    = {15950321},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2005.05.005}
}

@article{tweedie2012-22642825,
  author  = {Tweedie, D. and Ferguson, R. A. and Fishman, K. and Frankola, K. A. and Van Praag, H. and Holloway, H. W. and Luo, W. and Li, Y. and others},
  title   = {{Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2012},
  doi     = {10.1186/1742-2094-9-106},
  pmid    = {22642825},
  url     = {https://doi.org/10.1186/1742-2094-9-106}
}

@article{zhong2007-17548753,
  author  = {Zhong, Z. and Ewers, M. and Teipel, S. and Bürger, K. and Wallin, A. and Blennow, K. and He, P. and McAllister, C. and others},
  title   = {{Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment}},
  journal = {Archives of general psychiatry},
  year    = {2007},
  doi     = {10.1001/archpsyc.64.6.718},
  pmid    = {17548753},
  url     = {https://doi.org/10.1001/archpsyc.64.6.718}
}

@article{villemagne2009-20008660,
  author  = {Villemagne, V. L. and Ataka, S. and Mizuno, T. and Brooks, W. S. and Wada, Y. and Kondo, M. and Jones, G. and Watanabe, Y. and others},
  title   = {{High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2009.285},
  pmid    = {20008660},
  url     = {https://doi.org/10.1001/archneurol.2009.285}
}

@article{middeldorp2016-27598869,
  author  = {Middeldorp, J. and Lehallier, B. and Villeda, S. A. and Miedema, S. S. and Evans, E. and Czirr, E. and Zhang, H. and Luo, J. and others},
  title   = {{Preclinical Assessment of Young Blood Plasma for Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2016},
  doi     = {10.1001/jamaneurol.2016.3185},
  pmid    = {27598869},
  url     = {https://doi.org/10.1001/jamaneurol.2016.3185}
}

@article{gomes2019-31414210,
  author  = {Gomes, L. A. and Hipp, S. A. and Rijal Upadhaya, A. and Balakrishnan, K. and Ospitalieri, S. and Koper, M. J. and Largo-Barrientos, P. and Uytterhoeven, V. and others},
  title   = {{Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02053-5},
  pmid    = {31414210},
  url     = {https://doi.org/10.1007/s00401-019-02053-5}
}

@article{daniels2026-41709913,
  author  = {Daniels, Alisha J. and McDade, Eric and Llibre‐Guerra, Jorge J. and Xiong, Chengjie and Perrin, Richard J. and Ibáñez, Laura and Supnet‐Bell, Charlene and Cruchaga, Carlos C and others},
  title   = {{15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN}},
  journal = {npj Dementia},
  year    = {2026},
  doi     = {10.1038/s44400-025-00047-7},
  pmid    = {41709913},
  url     = {https://doi.org/10.1038/s44400-025-00047-7}
}

@article{althani2021-33769987,
  author  = {Al-Thani, H. F. and Ahmad, M. N. and Younes, S. and Zayed, H.},
  title   = {{Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries: A Systematic Review}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2021},
  doi     = {10.1097/wad.0000000000000447},
  pmid    = {33769987},
  url     = {https://doi.org/10.1097/wad.0000000000000447}
}

@article{wong2020-30797548,
  author  = {Wong, Tsz Hang and Seelaar, Harro and Melhem, Shamiram and Rozemuller, Annemieke J M and van Swieten, John C},
  title   = {{Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations}},
  journal = {Neurobiology of aging},
  year    = {2020},
  doi     = {10.1016/j.neurobiolaging.2019.01.015},
  pmid    = {30797548},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2019.01.015}
}

@article{colijn2024-38227890,
  author  = {Colijn, Mark A and Ismail, Zahinoor},
  title   = {{Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2024},
  doi     = {10.1097/wad.0000000000000599},
  pmid    = {38227890},
  url     = {https://doi.org/10.1097/wad.0000000000000599}
}

@article{nik2021-33720885,
  author  = {Nik, Seyyed Hani Moussavi and Porter, Tenielle and Newman, Morgan and Bartlett, Benjamin and Khan, Imran and Sabale, Miheer and Eccles, Melissa and Woodfield, Amy and others},
  title   = {{Relevance of a Truncated PRESENILIN 2 Transcript to Alzheimer's Disease and Neurodegeneration}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-201133},
  pmid    = {33720885},
  url     = {https://doi.org/10.3233/jad-201133}
}

@article{jiang2019-30598257,
  author  = {Jiang, Bin and Zhou, Jiong and Li, Hong-Lei and Chen, Yan-Gui and Cheng, Hong-Rong and Ye, Ling-Qi and Liu, De-Shan and Chen, Dian-Fu and others},
  title   = {{Mutation screening in Chinese patients with familial Alzheimer's disease by whole-exome sequencing}},
  journal = {Neurobiology of aging},
  year    = {2019},
  doi     = {10.1016/j.neurobiolaging.2018.11.024},
  pmid    = {30598257},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2018.11.024}
}

@article{lukiw2005-16151530,
  author  = {Lukiw, W. J. and Cui, J. G. and Marcheselli, V. L. and Bodker, M. and Botkjaer, A. and Gotlinger, K. and Serhan, C. N. and Bazan, N. G.},
  title   = {{A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2005},
  doi     = {10.1172/jci25420},
  pmid    = {16151530},
  url     = {https://doi.org/10.1172/jci25420}
}

@article{hsiao1995-7576662,
  author  = {Hsiao, K. K. and Borchelt, D. R. and Olson, K. and Johannsdottir, R. and Kitt, C. and Yunis, W. and Xu, S. and Eckman, C. and others},
  title   = {{Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins}},
  journal = {Neuron},
  year    = {1995},
  doi     = {10.1016/0896-6273(95)90107-8},
  pmid    = {7576662},
  url     = {https://doi.org/10.1016/0896-6273(95)90107-8}
}

@article{selkoe1988-3140239,
  author  = {Selkoe, D. J. and Podlisny, M. B. and Joachim, C. L. and Vickers, E. A. and Lee, G. and Fritz, L. C. and Oltersdorf, T.},
  title   = {{Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1988},
  doi     = {10.1073/pnas.85.19.7341},
  pmid    = {3140239},
  url     = {https://doi.org/10.1073/pnas.85.19.7341}
}

@article{naslund1994-8078890,
  author  = {Näslund, J. and Schierhorn, A. and Hellman, U. and Lannfelt, L. and Roses, A. D. and Tjernberg, L. O. and Silberring, J. and Gandy, S. E. and others},
  title   = {{Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.18.8378},
  pmid    = {8078890},
  url     = {https://doi.org/10.1073/pnas.91.18.8378}
}

@article{choi2009-19837759,
  author  = {Choi, SR. and Golding, G. and Zhuang, Z. and Zhang, W. and Lim, N. and Hefti, F. and Benedum, T. E. and Kilbourn, M. R. and others},
  title   = {{Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2009},
  doi     = {10.2967/jnumed.109.065284},
  pmid    = {19837759},
  url     = {https://doi.org/10.2967/jnumed.109.065284}
}

@article{rezaizadeh2008-18457818,
  author  = {Rezai-Zadeh, K. and Arendash, G. W. and Hou, H. and Fernandez, F. and Jensen, M. and Runfeldt, M. and Shytle, R. D. and Tan, J.},
  title   = {{Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice}},
  journal = {Brain research},
  year    = {2008},
  doi     = {10.1016/j.brainres.2008.02.107},
  pmid    = {18457818},
  url     = {https://doi.org/10.1016/j.brainres.2008.02.107}
}

@article{destrooper2007-17268505,
  author  = {De Strooper, B.},
  title   = {{Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease}},
  journal = {EMBO reports},
  year    = {2007},
  doi     = {10.1038/sj.embor.7400897},
  pmid    = {17268505},
  url     = {https://doi.org/10.1038/sj.embor.7400897}
}

@article{puzzo2011-21472769,
  author  = {Puzzo, D. and Privitera, L. and Fa', M. and Staniszewski, A. and Hashimoto, G. and Aziz, F. and Sakurai, M. and Ribe, E. M. and others},
  title   = {{Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory}},
  journal = {Annals of neurology},
  year    = {2011},
  doi     = {10.1002/ana.22313},
  pmid    = {21472769},
  url     = {https://doi.org/10.1002/ana.22313}
}

@article{rogers1999-10037734,
  author  = {Rogers, J. T. and Leiter, L. M. and McPhee, J. and Cahill, C. M. and Zhan, S. S. and Potter, H. and Nilsson, L. N.},
  title   = {{Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences}},
  journal = {The Journal of biological chemistry},
  year    = {1999},
  doi     = {10.1074/jbc.274.10.6421},
  pmid    = {10037734},
  url     = {https://doi.org/10.1074/jbc.274.10.6421}
}

@article{dong2009-19433662,
  author  = {Dong, Y. and Zhang, G. and Zhang, B. and Moir, R. D. and Xia, W. and Marcantonio, E. R. and Culley, D. J. and Crosby, G. and others},
  title   = {{The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2009.48},
  pmid    = {19433662},
  url     = {https://doi.org/10.1001/archneurol.2009.48}
}

@article{areagomez2018-29491396,
  author  = {Area-Gomez, E. and de Groof, A. and Bonilla, E. and Montesinos, J. and Tanji, K. and Boldogh, I. and Pon, L. and Schon, E. A.},
  title   = {{A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease}},
  journal = {Cell death \& disease},
  year    = {2018},
  doi     = {10.1038/s41419-017-0215-0},
  pmid    = {29491396},
  url     = {https://doi.org/10.1038/s41419-017-0215-0}
}

@article{vonarnim2005-15749709,
  author  = {von Arnim, C. A. and Kinoshita, A. and Peltan, I. D. and Tangredi, M. M. and Herl, L. and Lee, B. M. and Spoelgen, R. and Hshieh, T. T. and others},
  title   = {{The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m414248200},
  pmid    = {15749709},
  url     = {https://doi.org/10.1074/jbc.m414248200}
}

@article{galvan2006-16641106,
  author  = {Galvan, V. and Gorostiza, O. F. and Banwait, S. and Ataie, M. and Logvinova, A. V. and Sitaraman, S. and Carlson, E. and Sagi, S. A. and others},
  title   = {{Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0509695103},
  pmid    = {16641106},
  url     = {https://doi.org/10.1073/pnas.0509695103}
}

@article{takeuchi2000-10880403,
  author  = {Takeuchi, A. and Irizarry, M. C. and Duff, K. and Saido, T. C. and Hsiao Ashe, K. and Hasegawa, M. and Mann, D. M. and Hyman, B. T. and others},
  title   = {{Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss}},
  journal = {The American journal of pathology},
  year    = {2000},
  doi     = {10.1016/s0002-9440(10)64544-0},
  pmid    = {10880403},
  url     = {https://doi.org/10.1016/s0002-9440(10)64544-0}
}

@article{dubal2015-25673831,
  author  = {Dubal, D. B. and Zhu, L. and Sanchez, P. E. and Worden, K. and Broestl, L. and Johnson, E. and Ho, K. and Yu, G. Q. and others},
  title   = {{Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.5791-12.2015},
  pmid    = {25673831},
  url     = {https://doi.org/10.1523/jneurosci.5791-12.2015}
}

@article{colciaghi2004-14872043,
  author  = {Colciaghi, F. and Marcello, E. and Borroni, B. and Zimmermann, M. and Caltagirone, C. and Cattabeni, F. and Padovani, A. and Di Luca, M.},
  title   = {{Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000106953.49802.9c},
  pmid    = {14872043},
  url     = {https://doi.org/10.1212/01.wnl.0000106953.49802.9c}
}

@article{hemming2008-18942891,
  author  = {Hemming, M. L. and Elias, J. E. and Gygi, S. P. and Selkoe, D. J.},
  title   = {{Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements}},
  journal = {PLoS biology},
  year    = {2008},
  doi     = {10.1371/journal.pbio.0060257},
  pmid    = {18942891},
  url     = {https://doi.org/10.1371/journal.pbio.0060257}
}

@article{liu2007-17564960,
  author  = {Liu, F. and Arias-Vásquez, A. and Sleegers, K. and Aulchenko, Y. S. and Kayser, M. and Sanchez-Juan, P. and Feng, B. J. and Bertoli-Avella, A. M. and others},
  title   = {{A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population}},
  journal = {American journal of human genetics},
  year    = {2007},
  doi     = {10.1086/518720},
  pmid    = {17564960},
  url     = {https://doi.org/10.1086/518720}
}

@article{andreasson2016-27248001,
  author  = {Andreasson, K. I. and Bachstetter, A. D. and Colonna, M. and Ginhoux, F. and Holmes, C. and Lamb, B. and Landreth, G. and Lee, D. C. and others},
  title   = {{Targeting innate immunity for neurodegenerative disorders of the central nervous system}},
  journal = {Journal of neurochemistry},
  year    = {2016},
  doi     = {10.1111/jnc.13667},
  pmid    = {27248001},
  url     = {https://doi.org/10.1111/jnc.13667}
}

@article{derossi2020-32160554,
  author  = {De Rossi, P. and Nomura, T. and Andrew, R. J. and Masse, N. Y. and Sampathkumar, V. and Musial, T. F. and Sudwarts, A. and Recupero, A. J. and others},
  title   = {{Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation}},
  journal = {Cell reports},
  year    = {2020},
  doi     = {10.1016/j.celrep.2020.02.026},
  pmid    = {32160554},
  url     = {https://doi.org/10.1016/j.celrep.2020.02.026}
}

@article{ringman2016-26888304,
  author  = {Ringman, J. M. and Monsell, S. and Ng, D. W. and Zhou, Y. and Nguyen, A. and Coppola, G. and Van Berlo, V. and Mendez, M. F. and others},
  title   = {{Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2016},
  doi     = {10.1093/jnen/nlv028},
  pmid    = {26888304},
  url     = {https://doi.org/10.1093/jnen/nlv028}
}

@article{nsongo2017-28106563,
  author  = {N'Songo, Aurelie and Carrasquillo, Minerva M and Wang, Xue and Nguyen, Thuy and Asmann, Yan and Younkin, Steven G and Allen, Mariet and Duara, Ranjan and others},
  title   = {{Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-161185},
  pmid    = {28106563},
  url     = {https://doi.org/10.3233/jad-161185}
}

@article{wong2004-14709552,
  author  = {Wong, G. T. and Manfra, D. and Poulet, F. M. and Zhang, Q. and Josien, H. and Bara, T. and Engstrom, L. and Pinzon-Ortiz, M. and others},
  title   = {{Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation}},
  journal = {The Journal of biological chemistry},
  year    = {2004},
  doi     = {10.1074/jbc.m311652200},
  pmid    = {14709552},
  url     = {https://doi.org/10.1074/jbc.m311652200}
}

@article{johnsonwood1997-9037091,
  author  = {Johnson-Wood, K. and Lee, M. and Motter, R. and Hu, K. and Gordon, G. and Barbour, R. and Khan, K. and Gordon, M. and others},
  title   = {{Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.4.1550},
  pmid    = {9037091},
  url     = {https://doi.org/10.1073/pnas.94.4.1550}
}

@article{butterfield2013-23249141,
  author  = {Butterfield, D. A. and Swomley, A. M. and Sultana, R.},
  title   = {{Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression}},
  journal = {Antioxidants \& redox signaling},
  year    = {2013},
  doi     = {10.1089/ars.2012.5027},
  pmid    = {23249141},
  url     = {https://doi.org/10.1089/ars.2012.5027}
}

@article{destrooper2000-10806097,
  author  = {De Strooper, B. and Annaert, W.},
  title   = {{Proteolytic processing and cell biological functions of the amyloid precursor protein}},
  journal = {Journal of cell science},
  year    = {2000},
  doi     = {10.1242/jcs.113.11.1857},
  pmid    = {10806097},
  url     = {https://doi.org/10.1242/jcs.113.11.1857}
}

@article{gong2004-15578094,
  author  = {Gong, B. and Vitolo, O. V. and Trinchese, F. and Liu, S. and Shelanski, M. and Arancio, O.},
  title   = {{Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment}},
  journal = {The Journal of clinical investigation},
  year    = {2004},
  doi     = {10.1172/jci22831},
  pmid    = {15578094},
  url     = {https://doi.org/10.1172/jci22831}
}

@article{buxbaum1990-2116015,
  author  = {Buxbaum, J. D. and Gandy, S. E. and Cicchetti, P. and Ehrlich, M. E. and Czernik, A. J. and Fracasso, R. P. and Ramabhadran, T. V. and Unterbeck, A. J. and others},
  title   = {{Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1990},
  doi     = {10.1073/pnas.87.15.6003},
  pmid    = {2116015},
  url     = {https://doi.org/10.1073/pnas.87.15.6003}
}

@article{trinchese2004-15174014,
  author  = {Trinchese, F. and Liu, S. and Battaglia, F. and Walter, S. and Mathews, P. M. and Arancio, O.},
  title   = {{Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice}},
  journal = {Annals of neurology},
  year    = {2004},
  doi     = {10.1002/ana.20101},
  pmid    = {15174014},
  url     = {https://doi.org/10.1002/ana.20101}
}

@article{greenfield1999-9892704,
  author  = {Greenfield, J. P. and Tsai, J. and Gouras, G. K. and Hai, B. and Thinakaran, G. and Checler, F. and Sisodia, S. S. and Greengard, P. and others},
  title   = {{Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1999},
  doi     = {10.1073/pnas.96.2.742},
  pmid    = {9892704},
  url     = {https://doi.org/10.1073/pnas.96.2.742}
}

@article{wunderlich2013-24078628,
  author  = {Wunderlich, P. and Glebov, K. and Kemmerling, N. and Tien, N. T. and Neumann, H. and Walter, J.},
  title   = {{Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m113.517540},
  pmid    = {24078628},
  url     = {https://doi.org/10.1074/jbc.m113.517540}
}

@article{nalbantoglu1997-9168112,
  author  = {Nalbantoglu, J. and Tirado-Santiago, G. and Lahsaïni, A. and Poirier, J. and Goncalves, O. and Verge, G. and Momoli, F. and Welner, S. A. and others},
  title   = {{Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein}},
  journal = {Nature},
  year    = {1997},
  doi     = {10.1038/387500a0},
  pmid    = {9168112},
  url     = {https://doi.org/10.1038/387500a0}
}

@article{wong2005-15824102,
  author  = {Wong, H. K. and Sakurai, T. and Oyama, F. and Kaneko, K. and Wada, K. and Miyazaki, H. and Kurosawa, M. and De Strooper, B. and others},
  title   = {{beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m414648200},
  pmid    = {15824102},
  url     = {https://doi.org/10.1074/jbc.m414648200}
}

@article{citron1994-7991571,
  author  = {Citron, M. and Vigo-Pelfrey, C. and Teplow, D. B. and Miller, C. and Schenk, D. and Johnston, J. and Winblad, B. and Venizelos, N. and others},
  title   = {{Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.25.11993},
  pmid    = {7991571},
  url     = {https://doi.org/10.1073/pnas.91.25.11993}
}

@article{cho2011-21771791,
  author  = {Cho, S. H. and Sun, B. and Zhou, Y. and Kauppinen, T. M. and Halabisky, B. and Wes, P. and Ransohoff, R. M. and Gan, L.},
  title   = {{CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m111.254268},
  pmid    = {21771791},
  url     = {https://doi.org/10.1074/jbc.m111.254268}
}

@article{xu1997-9108049,
  author  = {Xu, H. and Sweeney, D. and Wang, R. and Thinakaran, G. and Lo, A. C. and Sisodia, S. S. and Greengard, P. and Gandy, S.},
  title   = {{Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.8.3748},
  pmid    = {9108049},
  url     = {https://doi.org/10.1073/pnas.94.8.3748}
}

@article{cras1991-1652752,
  author  = {Cras, P. and Kawai, M. and Lowery, D. and Gonzalez-DeWhitt, P. and Greenberg, B. and Perry, G.},
  title   = {{Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1991},
  doi     = {10.1073/pnas.88.17.7552},
  pmid    = {1652752},
  url     = {https://doi.org/10.1073/pnas.88.17.7552}
}

@article{citron1996-8917563,
  author  = {Citron, M. and Diehl, T. S. and Gordon, G. and Biere, A. L. and Seubert, P. and Selkoe, D. J.},
  title   = {{Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1996},
  doi     = {10.1073/pnas.93.23.13170},
  pmid    = {8917563},
  url     = {https://doi.org/10.1073/pnas.93.23.13170}
}

@article{xie2006-16645451,
  author  = {Xie, Z. and Dong, Y. and Maeda, U. and Alfille, P. and Culley, D. J. and Crosby, G. and Tanzi, R. E.},
  title   = {{The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels}},
  journal = {Anesthesiology},
  year    = {2006},
  doi     = {10.1097/00000542-200605000-00015},
  pmid    = {16645451},
  url     = {https://doi.org/10.1097/00000542-200605000-00015}
}

@article{smith1990-2111585,
  author  = {Smith, R. P. and Higuchi, D. A. and Broze, G. J.},
  title   = {{Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein}},
  journal = {Science (New York, N.Y.)},
  year    = {1990},
  doi     = {10.1126/science.2111585},
  pmid    = {2111585},
  url     = {https://doi.org/10.1126/science.2111585}
}

@article{jankowsky2005-16279840,
  author  = {Jankowsky, J. L. and Slunt, H. H. and Gonzales, V. and Savonenko, A. V. and Wen, J. C. and Jenkins, N. A. and Copeland, N. G. and Younkin, L. H. and others},
  title   = {{Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease}},
  journal = {PLoS medicine},
  year    = {2005},
  doi     = {10.1371/journal.pmed.0020355},
  pmid    = {16279840},
  url     = {https://doi.org/10.1371/journal.pmed.0020355}
}

@article{bakernigh2015-25732182,
  author  = {Baker-Nigh, A. and Vahedi, S. and Davis, E. G. and Weintraub, S. and Bigio, E. H. and Klein, W. L. and Geula, C.},
  title   = {{Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2015},
  doi     = {10.1093/brain/awv024},
  pmid    = {25732182},
  url     = {https://doi.org/10.1093/brain/awv024}
}

@article{xia1997-9223340,
  author  = {Xia, W. and Zhang, J. and Perez, R. and Koo, E. H. and Selkoe, D. J.},
  title   = {{Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.15.8208},
  pmid    = {9223340},
  url     = {https://doi.org/10.1073/pnas.94.15.8208}
}

@article{hick2015-25432317,
  author  = {Hick, M. and Herrmann, U. and Weyer, S. W. and Mallm, J. P. and Tschäpe, J. A. and Borgers, M. and Mercken, M. and Roth, F. C. and others},
  title   = {{Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity}},
  journal = {Acta neuropathologica},
  year    = {2015},
  doi     = {10.1007/s00401-014-1368-x},
  pmid    = {25432317},
  url     = {https://doi.org/10.1007/s00401-014-1368-x}
}

@article{weyer2011-21522131,
  author  = {Weyer, S. W. and Klevanski, M. and Delekate, A. and Voikar, V. and Aydin, D. and Hick, M. and Filippov, M. and Drost, N. and others},
  title   = {{APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP}},
  journal = {The EMBO journal},
  year    = {2011},
  doi     = {10.1038/emboj.2011.119},
  pmid    = {21522131},
  url     = {https://doi.org/10.1038/emboj.2011.119}
}

@article{zhou2012-22692213,
  author  = {Zhou, L. and Barão, S. and Laga, M. and Bockstael, K. and Borgers, M. and Gijsen, H. and Annaert, W. and Moechars, D. and others},
  title   = {{The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.377465},
  pmid    = {22692213},
  url     = {https://doi.org/10.1074/jbc.m112.377465}
}

@article{derrico2020-33061903,
  author  = {d'Errico, P. and Meyer-Luehmann, M.},
  title   = {{Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2020},
  doi     = {10.3389/fnagi.2020.00265},
  pmid    = {33061903},
  url     = {https://doi.org/10.3389/fnagi.2020.00265}
}

@article{shen2008-18436531,
  author  = {Shen, C. and Chen, Y. and Liu, H. and Zhang, K. and Zhang, T. and Lin, A. and Jing, N.},
  title   = {{Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m800013200},
  pmid    = {18436531},
  url     = {https://doi.org/10.1074/jbc.m800013200}
}

@article{zetterberg2011-22194817,
  author  = {Zetterberg, H. and Mörtberg, E. and Song, L. and Chang, L. and Provuncher, G. K. and Patel, P. P. and Ferrell, E. and Fournier, D. R. and others},
  title   = {{Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans}},
  journal = {PloS one},
  year    = {2011},
  doi     = {10.1371/journal.pone.0028263},
  pmid    = {22194817},
  url     = {https://doi.org/10.1371/journal.pone.0028263}
}

@article{ayton2015-25716857,
  author  = {Ayton, S. and Lei, P. and Hare, D. J. and Duce, J. A. and George, J. L. and Adlard, P. A. and McLean, C. and Rogers, J. T. and others},
  title   = {{Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.3439-14.2015},
  pmid    = {25716857},
  url     = {https://doi.org/10.1523/jneurosci.3439-14.2015}
}

@article{bao2022-35347329,
  author  = {Bao, F. and Deng, Y. and Wan, S. and Shen, S. Q. and Wang, B. and Dai, Q. and Altschuler, S. J. and Wu, L. F.},
  title   = {{Integrative spatial analysis of cell morphologies and transcriptional states with MUSE}},
  journal = {Nature biotechnology},
  year    = {2022},
  doi     = {10.1038/s41587-022-01251-z},
  pmid    = {35347329},
  url     = {https://doi.org/10.1038/s41587-022-01251-z}
}

@article{barberocamps2018-29862881,
  author  = {Barbero-Camps, E. and Roca-Agujetas, V. and Bartolessis, I. and de Dios, C. and Fernández-Checa, J. C. and Marí, M. and Morales, A. and Hartmann, T. and others},
  title   = {{Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion}},
  journal = {Autophagy},
  year    = {2018},
  doi     = {10.1080/15548627.2018.1438807},
  pmid    = {29862881},
  url     = {https://doi.org/10.1080/15548627.2018.1438807}
}

@article{deneubourg2022-34130600,
  author  = {Deneubourg, C. and Ramm, M. and Smith, L. J. and Baron, O. and Singh, K. and Byrne, S. C. and Duchen, M. R. and Gautel, M. and others},
  title   = {{The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy}},
  journal = {Autophagy},
  year    = {2022},
  doi     = {10.1080/15548627.2021.1943177},
  pmid    = {34130600},
  url     = {https://doi.org/10.1080/15548627.2021.1943177}
}

@article{hemming2007-17760499,
  author  = {Hemming, M. L. and Patterson, M. and Reske-Nielsen, C. and Lin, L. and Isacson, O. and Selkoe, D. J.},
  title   = {{Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease}},
  journal = {PLoS medicine},
  year    = {2007},
  doi     = {10.1371/journal.pmed.0040262},
  pmid    = {17760499},
  url     = {https://doi.org/10.1371/journal.pmed.0040262}
}

@article{rocaagujetas2021-33685483,
  author  = {Roca-Agujetas, V. and Barbero-Camps, E. and de Dios, C. and Podlesniy, P. and Abadin, X. and Morales, A. and Marí, M. and Trullàs, R. and others},
  title   = {{Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00435-6},
  pmid    = {33685483},
  url     = {https://doi.org/10.1186/s13024-021-00435-6}
}

@article{che2026-41512220,
  author  = {Che, Yanfei and Yu, Ziman and Ji, Songjie and Yang, Dan},
  title   = {{Decoding TREM2 Signaling Pathways}},
  journal = {Neurology Neuroimmunology \& Neuroinflammation},
  year    = {2026},
  doi     = {10.1212/nxi.0000000000200527},
  pmid    = {41512220},
  url     = {https://doi.org/10.1212/nxi.0000000000200527}
}

@article{chelban2021-33969176,
  author  = {Chelban, Viorica and Breza, Marianthi and Szaruga, Maria and Vandrovcova, Jana and Murphy, David and Lee, Chia-Ju and Alikhwan, Sondos and Bourinaris, Thomas and others},
  title   = {{Spastic paraplegia preceding PSEN1-related familial Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2021},
  doi     = {10.1002/dad2.12186},
  pmid    = {33969176},
  url     = {https://doi.org/10.1002/dad2.12186}
}

@article{jiao2014-24650794,
  author  = {Jiao, Bin and Tang, Beisha and Liu, Xiaoyan and Xu, Jun and Wang, Yanjiang and Zhou, Lin and Zhang, Fufeng and Yan, Xinxiang and others},
  title   = {{Mutational analysis in early-onset familial Alzheimer's disease in Mainland China}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.02.014},
  pmid    = {24650794},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.02.014}
}

@article{fukumoto2002-12223024,
  author  = {Fukumoto, H. and Cheung, B. S. and Hyman, B. T. and Irizarry, M. C.},
  title   = {{Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2002},
  doi     = {10.1001/archneur.59.9.1381},
  pmid    = {12223024},
  url     = {https://doi.org/10.1001/archneur.59.9.1381}
}

@article{mrak2005-15639313,
  author  = {Mrak, R. E. and Griffin, W. S.},
  title   = {{Glia and their cytokines in progression of neurodegeneration}},
  journal = {Neurobiology of aging},
  year    = {2005},
  doi     = {10.1016/j.neurobiolaging.2004.05.010},
  pmid    = {15639313},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.05.010}
}

@article{arispe1993-7504270,
  author  = {Arispe, N. and Pollard, H. B. and Rojas, E.},
  title   = {{Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.22.10573},
  pmid    = {7504270},
  url     = {https://doi.org/10.1073/pnas.90.22.10573}
}

@article{cataldo1990-1692625,
  author  = {Cataldo, A. M. and Nixon, R. A.},
  title   = {{Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1990},
  doi     = {10.1073/pnas.87.10.3861},
  pmid    = {1692625},
  url     = {https://doi.org/10.1073/pnas.87.10.3861}
}

@article{williams2012-21982844,
  author  = {Williams, R. J. and Spencer, J. P.},
  title   = {{Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease}},
  journal = {Free radical biology \& medicine},
  year    = {2012},
  doi     = {10.1016/j.freeradbiomed.2011.09.010},
  pmid    = {21982844},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2011.09.010}
}

@article{heneka2006-16452658,
  author  = {Heneka, M. T. and Ramanathan, M. and Jacobs, A. H. and Dumitrescu-Ozimek, L. and Bilkei-Gorzo, A. and Debeir, T. and Sastre, M. and Galldiks, N. and others},
  title   = {{Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.4236-05.2006},
  pmid    = {16452658},
  url     = {https://doi.org/10.1523/jneurosci.4236-05.2006}
}

@article{wojtowicz2020-32170673,
  author  = {Wójtowicz, S. and Strosznajder, A. K. and Jeżyna, M. and Strosznajder, J. B.},
  title   = {{The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders}},
  journal = {Neurochemical research},
  year    = {2020},
  doi     = {10.1007/s11064-020-02993-5},
  pmid    = {32170673},
  url     = {https://doi.org/10.1007/s11064-020-02993-5}
}

@article{kumarsingh2006-16752394,
  author  = {Kumar-Singh, S. and Theuns, J. and Van Broeck, B. and Pirici, D. and Vennekens, K. and Corsmit, E. and Cruts, M. and others},
  title   = {{Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40}},
  journal = {Human mutation},
  year    = {2006},
  doi     = {10.1002/humu.20336},
  pmid    = {16752394},
  url     = {https://doi.org/10.1002/humu.20336}
}

@article{bush1990-2118534,
  author  = {Bush, A. I. and Martins, R. N. and Rumble, B. and Moir, R. and Fuller, S. and Milward, E. and Currie, J. and Ames, D. and others},
  title   = {{The amyloid precursor protein of Alzheimer's disease is released by human platelets}},
  journal = {The Journal of biological chemistry},
  year    = {1990},
  doi     = {10.1016/s0021-9258(18)55493-4},
  pmid    = {2118534},
  url     = {https://doi.org/10.1016/s0021-9258(18)55493-4}
}

@article{vandam2003-12542676,
  author  = {Van Dam, D. and D'Hooge, R. and Staufenbiel, M. and Van Ginneken, C. and Van Meir, F. and De Deyn, P. P.},
  title   = {{Age-dependent cognitive decline in the APP23 model precedes amyloid deposition}},
  journal = {The European journal of neuroscience},
  year    = {2003},
  doi     = {10.1046/j.1460-9568.2003.02444.x},
  pmid    = {12542676},
  url     = {https://doi.org/10.1046/j.1460-9568.2003.02444.x}
}

@article{green2007-17442823,
  author  = {Green, K. N. and Martinez-Coria, H. and Khashwji, H. and Hall, E. B. and Yurko-Mauro, K. A. and Ellis, L. and LaFerla, F. M.},
  title   = {{Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.0055-07.2007},
  pmid    = {17442823},
  url     = {https://doi.org/10.1523/jneurosci.0055-07.2007}
}

@article{white2006-16648635,
  author  = {White, A. R. and Du, T. and Laughton, K. M. and Volitakis, I. and Sharples, R. A. and Xilinas, M. E. and Hoke, D. E. and Holsinger, R. M. and others},
  title   = {{Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m602487200},
  pmid    = {16648635},
  url     = {https://doi.org/10.1074/jbc.m602487200}
}

@article{oules2012-22915123,
  author  = {Oulès, B. and Del Prete, D. and Greco, B. and Zhang, X. and Lauritzen, I. and Sevalle, J. and Moreno, S. and Paterlini-Bréchot, P. and others},
  title   = {{Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.0875-12.2012},
  pmid    = {22915123},
  url     = {https://doi.org/10.1523/jneurosci.0875-12.2012}
}

@article{buxbaum1998-9822724,
  author  = {Buxbaum, J. D. and Thinakaran, G. and Koliatsos, V. and O'Callahan, J. and Slunt, H. H. and Price, D. L. and Sisodia, S. S.},
  title   = {{Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1998},
  doi     = {10.1523/jneurosci.18-23-09629.1998},
  pmid    = {9822724},
  url     = {https://doi.org/10.1523/jneurosci.18-23-09629.1998}
}

@article{murakami2011-22072713,
  author  = {Murakami, K. and Murata, N. and Noda, Y. and Tahara, S. and Kaneko, T. and Kinoshita, N. and Hatsuta, H. and Murayama, S. and others},
  title   = {{SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m111.279208},
  pmid    = {22072713},
  url     = {https://doi.org/10.1074/jbc.m111.279208}
}

@article{sheng1996-8892349,
  author  = {Sheng, J. G. and Ito, K. and Skinner, R. D. and Mrak, R. E. and Rovnaghi, C. R. and Van Eldik, L. J. and Griffin, W. S.},
  title   = {{In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis}},
  journal = {Neurobiology of aging},
  year    = {1996},
  doi     = {10.1016/0197-4580(96)00104-2},
  pmid    = {8892349},
  url     = {https://doi.org/10.1016/0197-4580(96)00104-2}
}

@article{smith2009-19805389,
  author  = {Smith, D. L. and Pozueta, J. and Gong, B. and Arancio, O. and Shelanski, M.},
  title   = {{Reversal of long-term dendritic spine alterations in Alzheimer disease models}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0908706106},
  pmid    = {19805389},
  url     = {https://doi.org/10.1073/pnas.0908706106}
}

@article{du2001-11552007,
  author  = {Du, Y. and Dodel, R. and Hampel, H. and Buerger, K. and Lin, S. and Eastwood, B. and Bales, K. and Gao, F. and others},
  title   = {{Reduced levels of amyloid beta-peptide antibody in Alzheimer disease}},
  journal = {Neurology},
  year    = {2001},
  doi     = {10.1212/wnl.57.5.801},
  pmid    = {11552007},
  url     = {https://doi.org/10.1212/wnl.57.5.801}
}

@article{grossi2013-23951225,
  author  = {Grossi, C. and Rigacci, S. and Ambrosini, S. and Ed Dami, T. and Luccarini, I. and Traini, C. and Failli, P. and Berti, A. and others},
  title   = {{The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0071702},
  pmid    = {23951225},
  url     = {https://doi.org/10.1371/journal.pone.0071702}
}

@article{sabo2001-11425871,
  author  = {Sabo, S. L. and Ikin, A. F. and Buxbaum, J. D. and Greengard, P.},
  title   = {{The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement}},
  journal = {The Journal of cell biology},
  year    = {2001},
  doi     = {10.1083/jcb.153.7.1403},
  pmid    = {11425871},
  url     = {https://doi.org/10.1083/jcb.153.7.1403}
}

@article{jiang1998-9501252,
  author  = {Jiang, M. and Gold, M. S. and Boulay, G. and Spicher, K. and Peyton, M. and Brabet, P. and Srinivasan, Y. and Rudolph, U. and others},
  title   = {{Multiple neurological abnormalities in mice deficient in the G protein Go}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1998},
  doi     = {10.1073/pnas.95.6.3269},
  pmid    = {9501252},
  url     = {https://doi.org/10.1073/pnas.95.6.3269}
}

@article{vingtdeux2007-17468104,
  author  = {Vingtdeux, V. and Hamdane, M. and Loyens, A. and Gelé, P. and Drobeck, H. and Bégard, S. and Galas, M. C. and Delacourte, A. and others},
  title   = {{Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m609475200},
  pmid    = {17468104},
  url     = {https://doi.org/10.1074/jbc.m609475200}
}

@article{cho2010-20558735,
  author  = {Cho, H. H. and Cahill, C. M. and Vanderburg, C. R. and Scherzer, C. R. and Wang, B. and Huang, X. and Rogers, J. T.},
  title   = {{Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.149161},
  pmid    = {20558735},
  url     = {https://doi.org/10.1074/jbc.m110.149161}
}

@article{sergeant2003-12787077,
  author  = {Sergeant, N. and Bombois, S. and Ghestem, A. and Drobecq, H. and Kostanjevecki, V. and Missiaen, C. and Wattez, A. and David, J. P. and others},
  title   = {{Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach}},
  journal = {Journal of neurochemistry},
  year    = {2003},
  doi     = {10.1046/j.1471-4159.2003.01818.x},
  pmid    = {12787077},
  url     = {https://doi.org/10.1046/j.1471-4159.2003.01818.x}
}

@article{zhangnunes2006-16612980,
  author  = {Zhang-Nunes, S. X. and Maat-Schieman, M. L. and van Duinen, S. G. and Roos, R. A. and Frosch, M. P. and Greenberg, S. M.},
  title   = {{The cerebral beta-amyloid angiopathies: hereditary and sporadic}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2006},
  doi     = {10.1111/j.1750-3639.2006.tb00559.x},
  pmid    = {16612980},
  url     = {https://doi.org/10.1111/j.1750-3639.2006.tb00559.x}
}

@article{wood2014-24329875,
  author  = {Wood, W. G. and Li, L. and Müller, W. E. and Eckert, G. P.},
  title   = {{Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis}},
  journal = {Journal of neurochemistry},
  year    = {2014},
  doi     = {10.1111/jnc.12637},
  pmid    = {24329875},
  url     = {https://doi.org/10.1111/jnc.12637}
}

@article{butterfield2010-19854267,
  author  = {Butterfield, D. A. and Galvan, V. and Lange, M. B. and Tang, H. and Sowell, R. A. and Spilman, P. and Fombonne, J. and Gorostiza, O. and others},
  title   = {{In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP}},
  journal = {Free radical biology \& medicine},
  year    = {2010},
  doi     = {10.1016/j.freeradbiomed.2009.10.035},
  pmid    = {19854267},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2009.10.035}
}

@article{obregon2006-16624814,
  author  = {Obregon, D. F. and Rezai-Zadeh, K. and Bai, Y. and Sun, N. and Hou, H. and Ehrhart, J. and Zeng, J. and Mori, T. and others},
  title   = {{ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m600617200},
  pmid    = {16624814},
  url     = {https://doi.org/10.1074/jbc.m600617200}
}

@article{andrew2016-27474742,
  author  = {Andrew, R. J. and Kellett, K. A. and Thinakaran, G. and Hooper, N. M.},
  title   = {{A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis}},
  journal = {The Journal of biological chemistry},
  year    = {2016},
  doi     = {10.1074/jbc.r116.746032},
  pmid    = {27474742},
  url     = {https://doi.org/10.1074/jbc.r116.746032}
}

@article{mori2013-23409038,
  author  = {Mori, T. and Koyama, N. and Guillot-Sestier, M. V. and Tan, J. and Town, T.},
  title   = {{Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0055774},
  pmid    = {23409038},
  url     = {https://doi.org/10.1371/journal.pone.0055774}
}

@article{ostrowski2007-17646164,
  author  = {Ostrowski, S. M. and Wilkinson, B. L. and Golde, T. E. and Landreth, G.},
  title   = {{Statins reduce amyloid-beta production through inhibition of protein isoprenylation}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m702640200},
  pmid    = {17646164},
  url     = {https://doi.org/10.1074/jbc.m702640200}
}

@article{page2008-17962197,
  author  = {Page, R. M. and Baumann, K. and Tomioka, M. and Pérez-Revuelta, B. I. and Fukumori, A. and Jacobsen, H. and Flohr, A. and Luebbers, T. and others},
  title   = {{Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m708754200},
  pmid    = {17962197},
  url     = {https://doi.org/10.1074/jbc.m708754200}
}

@article{vetrivel2006-16432149,
  author  = {Vetrivel, K. S. and Thinakaran, G.},
  title   = {{Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000192107.17175.39},
  pmid    = {16432149},
  url     = {https://doi.org/10.1212/01.wnl.0000192107.17175.39}
}

@article{sevush1998-9561982,
  author  = {Sevush, S. and Jy, W. and Horstman, L. L. and Mao, W. W. and Kolodny, L. and Ahn, Y. S.},
  title   = {{Platelet activation in Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {1998},
  doi     = {10.1001/archneur.55.4.530},
  pmid    = {9561982},
  url     = {https://doi.org/10.1001/archneur.55.4.530}
}

@article{vardarajan2012-22673115,
  author  = {Vardarajan, B. N. and Bruesegem, S. Y. and Harbour, M. E. and Inzelberg, R. and Friedland, R. and St George-Hyslop, P. and Seaman, M. N. and Farrer, L. A.},
  title   = {{Identification of Alzheimer disease-associated variants in genes that regulate retromer function}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2012.04.020},
  pmid    = {22673115},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2012.04.020}
}

@article{elhachem2017-28508374,
  author  = {El-Hachem, N. and Haibe-Kains, B. and Khalil, A. and Kobeissy, F. H. and Nemer, G.},
  title   = {{AutoDock and AutoDockTools for Protein-Ligand Docking: Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) as a Case Study}},
  journal = {Methods in molecular biology (Clifton, N.J.)},
  year    = {2017},
  doi     = {10.1007/978-1-4939-6952-4_20},
  pmid    = {28508374},
  url     = {https://doi.org/10.1007/978-1-4939-6952-4_20}
}

@article{finckh2000-10631141,
  author  = {Finckh, U. and Müller-Thomsen, T. and Mann, U. and Eggers, C. and Marksteiner, J. and Meins, W. and Binetti, G. and Alberici, A. and others},
  title   = {{High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes}},
  journal = {American journal of human genetics},
  year    = {2000},
  doi     = {10.1086/302702},
  pmid    = {10631141},
  url     = {https://doi.org/10.1086/302702}
}

@article{park2014-24781082,
  author  = {Park, L. and Koizumi, K. and El Jamal, S. and Zhou, P. and Previti, M. L. and Van Nostrand, W. E. and Carlson, G. and Iadecola, C.},
  title   = {{Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy}},
  journal = {Stroke},
  year    = {2014},
  doi     = {10.1161/strokeaha.114.005179},
  pmid    = {24781082},
  url     = {https://doi.org/10.1161/strokeaha.114.005179}
}

@article{zhong2015-25957402,
  author  = {Zhong, L. and Chen, X. F. and Zhang, Z. L. and Wang, Z. and Shi, X. Z. and Xu, K. and Zhang, Y. W. and Xu, H. and others},
  title   = {{DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.645986},
  pmid    = {25957402},
  url     = {https://doi.org/10.1074/jbc.m115.645986}
}

@article{pedrini2005-15647781,
  author  = {Pedrini, S. and Carter, T. L. and Prendergast, G. and Petanceska, S. and Ehrlich, M. E. and Gandy, S.},
  title   = {{Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK}},
  journal = {PLoS medicine},
  year    = {2005},
  doi     = {10.1371/journal.pmed.0020018},
  pmid    = {15647781},
  url     = {https://doi.org/10.1371/journal.pmed.0020018}
}

@article{mori2012-22219198,
  author  = {Mori, T. and Rezai-Zadeh, K. and Koyama, N. and Arendash, G. W. and Yamaguchi, H. and Kakuda, N. and Horikoshi-Sakuraba, Y. and Tan, J. and others},
  title   = {{Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m111.294025},
  pmid    = {22219198},
  url     = {https://doi.org/10.1074/jbc.m111.294025}
}

@article{kook2014-24853300,
  author  = {Kook, S. Y. and Jeong, H. and Kang, M. J. and Park, R. and Shin, H. J. and Han, S. H. and Son, S. M. and Song, H. and others},
  title   = {{Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model}},
  journal = {Cell death and differentiation},
  year    = {2014},
  doi     = {10.1038/cdd.2014.67},
  pmid    = {24853300},
  url     = {https://doi.org/10.1038/cdd.2014.67}
}

@article{roveletlecrux2015-26194182,
  author  = {Rovelet-Lecrux, A. and Charbonnier, C. and Wallon, D. and Nicolas, G. and Seaman, M. N. and Pottier, C. and Breusegem, S. Y. and Mathur, P. P. and others},
  title   = {{De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease}},
  journal = {Molecular psychiatry},
  year    = {2015},
  doi     = {10.1038/mp.2015.100},
  pmid    = {26194182},
  url     = {https://doi.org/10.1038/mp.2015.100}
}

@article{xu2014-24441878,
  author  = {Xu, Z. and Dong, Y. and Wang, H. and Culley, D. J. and Marcantonio, E. R. and Crosby, G. and Tanzi, R. E. and Zhang, Y. and others},
  title   = {{Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice}},
  journal = {Scientific reports},
  year    = {2014},
  doi     = {10.1038/srep03766},
  pmid    = {24441878},
  url     = {https://doi.org/10.1038/srep03766}
}

@article{llibreguerra2025-41450326,
  author  = {Llibre‐Guerra, Jorge J. and Zhou, Jin and Schneider, Lon S. S. and Andreozzi, Erica M. and Clifford, David B. and Banerjee, Sibabrata and Wang, Guoqiao and McDade, Eric and others},
  title   = {{Baseline Participant Characteristics in the DIAN‐TU‐001 Trial}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_105299},
  pmid    = {41450326},
  url     = {https://doi.org/10.1002/alz70859_105299}
}

@article{wenham1991-1674030,
  author  = {Wenham, Philip R. and Price, W H and Blundell, Gillian},
  title   = {{Apolipoprotein E genotyping by one-stage PCR}},
  journal = {The Lancet},
  year    = {1991},
  doi     = {10.1016/0140-6736(91)92823-k},
  pmid    = {1674030},
  url     = {https://doi.org/10.1016/0140-6736(91)92823-k}
}

@article{chartierharlin1991-1944558,
  author  = {Chartier-Harlin, M. C. and Crawford, F. and Houlden, H. and Warren, A. and Hughes, D. and Fidani, L. and Goate, A. and Rossor, M. and others},
  title   = {{Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene}},
  journal = {Nature},
  year    = {1991},
  doi     = {10.1038/353844a0},
  pmid    = {1944558},
  url     = {https://doi.org/10.1038/353844a0}
}

@article{vossel2013-23835471,
  author  = {Vossel, K. A. and Beagle, A. J. and Rabinovici, G. D. and Shu, H. and Lee, S. E. and Naasan, G. and Hegde, M. and Cornes, S. B. and others},
  title   = {{Seizures and epileptiform activity in the early stages of Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.136},
  pmid    = {23835471},
  url     = {https://doi.org/10.1001/jamaneurol.2013.136}
}

@article{lee2022-35654956,
  author  = {Lee, J. H. and Yang, D. S. and Goulbourne, C. N. and Im, E. and Stavrides, P. and Pensalfini, A. and Chan, H. and Bouchet-Marquis, C. and others},
  title   = {{Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques}},
  journal = {Nature neuroscience},
  year    = {2022},
  doi     = {10.1038/s41593-022-01084-8},
  pmid    = {35654956},
  url     = {https://doi.org/10.1038/s41593-022-01084-8}
}

@article{gong1993-8395566,
  author  = {Gong, C. X. and Singh, T. J. and Grundke-Iqbal, I. and Iqbal, K.},
  title   = {{Phosphoprotein phosphatase activities in Alzheimer disease brain}},
  journal = {Journal of neurochemistry},
  year    = {1993},
  doi     = {10.1111/j.1471-4159.1993.tb03603.x},
  pmid    = {8395566},
  url     = {https://doi.org/10.1111/j.1471-4159.1993.tb03603.x}
}

@article{savonenko2005-15755686,
  author  = {Savonenko, A. and Xu, G. M. and Melnikova, T. and Morton, J. L. and Gonzales, V. and Wong, M. P. and Price, D. L. and Tang, F. and others},
  title   = {{Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2004.10.022},
  pmid    = {15755686},
  url     = {https://doi.org/10.1016/j.nbd.2004.10.022}
}

@article{colton2006-17005052,
  author  = {Colton, C. A. and Mott, R. T. and Sharpe, H. and Xu, Q. and Van Nostrand, W. E. and Vitek, M. P.},
  title   = {{Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-27},
  pmid    = {17005052},
  url     = {https://doi.org/10.1186/1742-2094-3-27}
}

@article{dong2004-15283960,
  author  = {Dong, H. and Goico, B. and Martin, M. and Csernansky, C. A. and Bertchume, A. and Csernansky, J. G.},
  title   = {{Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress}},
  journal = {Neuroscience},
  year    = {2004},
  doi     = {10.1016/j.neuroscience.2004.05.040},
  pmid    = {15283960},
  url     = {https://doi.org/10.1016/j.neuroscience.2004.05.040}
}

@article{jaffe1994-8175728,
  author  = {Jaffe, A. B. and Toran-Allerand, C. D. and Greengard, P. and Gandy, S. E.},
  title   = {{Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {1994},
  doi     = {10.1016/s0021-9258(17)36796-0},
  pmid    = {8175728},
  url     = {https://doi.org/10.1016/s0021-9258(17)36796-0}
}

@article{zawia2009-19245828,
  author  = {Zawia, N. H. and Lahiri, D. K. and Cardozo-Pelaez, F.},
  title   = {{Epigenetics, oxidative stress, and Alzheimer disease}},
  journal = {Free radical biology \& medicine},
  year    = {2009},
  doi     = {10.1016/j.freeradbiomed.2009.02.006},
  pmid    = {19245828},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2009.02.006}
}

@article{cole2008-18650431,
  author  = {Cole, S. L. and Vassar, R.},
  title   = {{The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.r800015200},
  pmid    = {18650431},
  url     = {https://doi.org/10.1074/jbc.r800015200}
}

@article{avrahami2013-23155049,
  author  = {Avrahami, L. and Farfara, D. and Shaham-Kol, M. and Vassar, R. and Frenkel, D. and Eldar-Finkelman, H.},
  title   = {{Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m112.409250},
  pmid    = {23155049},
  url     = {https://doi.org/10.1074/jbc.m112.409250}
}

@article{smith1999-10499440,
  author  = {Smith, D. H. and Chen, X. H. and Nonaka, M. and Trojanowski, J. Q. and Lee, V. M. and Saatman, K. E. and Leoni, M. J. and Xu, B. N. and others},
  title   = {{Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1999},
  doi     = {10.1097/00005072-199909000-00008},
  pmid    = {10499440},
  url     = {https://doi.org/10.1097/00005072-199909000-00008}
}

@article{griffin2006-16542445,
  author  = {Griffin, W. S. and Liu, L. and Li, Y. and Mrak, R. E. and Barger, S. W.},
  title   = {{Interleukin-1 mediates Alzheimer and Lewy body pathologies}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-5},
  pmid    = {16542445},
  url     = {https://doi.org/10.1186/1742-2094-3-5}
}

@article{saftig2015-26522965,
  author  = {Saftig, P. and Lichtenthaler, S. F.},
  title   = {{The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain}},
  journal = {Progress in neurobiology},
  year    = {2015},
  doi     = {10.1016/j.pneurobio.2015.10.003},
  pmid    = {26522965},
  url     = {https://doi.org/10.1016/j.pneurobio.2015.10.003}
}

@article{grimm2011-21324907,
  author  = {Grimm, M. O. and Kuchenbecker, J. and Grösgen, S. and Burg, V. K. and Hundsdörfer, B. and Rothhaar, T. L. and Friess, P. and de Wilde, M. C. and others},
  title   = {{Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.182329},
  pmid    = {21324907},
  url     = {https://doi.org/10.1074/jbc.m110.182329}
}

@article{jimenez2011-21460223,
  author  = {Jimenez, S. and Torres, M. and Vizuete, M. and Sanchez-Varo, R. and Sanchez-Mejias, E. and Trujillo-Estrada, L. and Carmona-Cuenca, I. and Caballero, C. and others},
  title   = {{Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.209718},
  pmid    = {21460223},
  url     = {https://doi.org/10.1074/jbc.m110.209718}
}

@article{huang2006-16636059,
  author  = {Huang, S. M. and Mouri, A. and Kokubo, H. and Nakajima, R. and Suemoto, T. and Higuchi, M. and Staufenbiel, M. and Noda, Y. and others},
  title   = {{Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m601372200},
  pmid    = {16636059},
  url     = {https://doi.org/10.1074/jbc.m601372200}
}

@article{agrawal2020-32973488,
  author  = {Agrawal, I. and Jha, S.},
  title   = {{Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia}},
  journal = {Frontiers in aging neuroscience},
  year    = {2020},
  doi     = {10.3389/fnagi.2020.00252},
  pmid    = {32973488},
  url     = {https://doi.org/10.3389/fnagi.2020.00252}
}

@article{ostergranite1996-8824314,
  author  = {Oster-Granite, M. L. and McPhie, D. L. and Greenan, J. and Neve, R. L.},
  title   = {{Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1996},
  doi     = {10.1523/jneurosci.16-21-06732.1996},
  pmid    = {8824314},
  url     = {https://doi.org/10.1523/jneurosci.16-21-06732.1996}
}

@article{austin2010-21127294,
  author  = {Austin, S. A. and Santhanam, A. V. and Katusic, Z. S.},
  title   = {{Endothelial nitric oxide modulates expression and processing of amyloid precursor protein}},
  journal = {Circulation research},
  year    = {2010},
  doi     = {10.1161/circresaha.110.233080},
  pmid    = {21127294},
  url     = {https://doi.org/10.1161/circresaha.110.233080}
}

@article{caporaso1992-1549591,
  author  = {Caporaso, G. L. and Gandy, S. E. and Buxbaum, J. D. and Greengard, P.},
  title   = {{Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.6.2252},
  pmid    = {1549591},
  url     = {https://doi.org/10.1073/pnas.89.6.2252}
}

@article{caporaso1994-8182461,
  author  = {Caporaso, G. L. and Takei, K. and Gandy, S. E. and Matteoli, M. and Mundigl, O. and Greengard, P. and De Camilli, P.},
  title   = {{Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1994},
  doi     = {10.1523/jneurosci.14-05-03122.1994},
  pmid    = {8182461},
  url     = {https://doi.org/10.1523/jneurosci.14-05-03122.1994}
}

@article{barrachina2009-19606065,
  author  = {Barrachina, M. and Ferrer, I.},
  title   = {{DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2009},
  doi     = {10.1097/nen.0b013e3181af2e46},
  pmid    = {19606065},
  url     = {https://doi.org/10.1097/nen.0b013e3181af2e46}
}

@article{lee2008-18276590,
  author  = {Lee, J. and Retamal, C. and Cuitiño, L. and Caruano-Yzermans, A. and Shin, J. E. and van Kerkhof, P. and Marzolo, M. P. and Bu, G.},
  title   = {{Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m800642200},
  pmid    = {18276590},
  url     = {https://doi.org/10.1074/jbc.m800642200}
}

@article{delprete2014-24902695,
  author  = {Del Prete, D. and Checler, F. and Chami, M.},
  title   = {{Ryanodine receptors: physiological function and deregulation in Alzheimer disease}},
  journal = {Molecular neurodegeneration},
  year    = {2014},
  doi     = {10.1186/1750-1326-9-21},
  pmid    = {24902695},
  url     = {https://doi.org/10.1186/1750-1326-9-21}
}

@article{zhang2005-15851850,
  author  = {Zhang, J. and Goodlett, D. R. and Quinn, J. F. and Peskind, E. and Kaye, J. A. and Zhou, Y. and Pan, C. and Yi, E. and others},
  title   = {{Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2005},
  doi     = {10.3233/jad-2005-7205},
  pmid    = {15851850},
  url     = {https://doi.org/10.3233/jad-2005-7205}
}

@article{vetrivel2009-19074428,
  author  = {Vetrivel, K. S. and Meckler, X. and Chen, Y. and Nguyen, P. D. and Seidah, N. G. and Vassar, R. and Wong, P. C. and Fukata, M. and others},
  title   = {{Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m808920200},
  pmid    = {19074428},
  url     = {https://doi.org/10.1074/jbc.m808920200}
}

@article{rushworth2013-23386614,
  author  = {Rushworth, J. V. and Griffiths, H. H. and Watt, N. T. and Hooper, N. M.},
  title   = {{Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m112.400358},
  pmid    = {23386614},
  url     = {https://doi.org/10.1074/jbc.m112.400358}
}

@article{gandy2010-20641005,
  author  = {Gandy, S. and Simon, A. J. and Steele, J. W. and Lublin, A. L. and Lah, J. J. and Walker, L. C. and Levey, A. I. and Krafft, G. A. and others},
  title   = {{Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.22052},
  pmid    = {20641005},
  url     = {https://doi.org/10.1002/ana.22052}
}

@article{schnoder2016-26663083,
  author  = {Schnöder, L. and Hao, W. and Qin, Y. and Liu, S. and Tomic, I. and Liu, X. and Fassbender, K. and Liu, Y.},
  title   = {{Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1}},
  journal = {The Journal of biological chemistry},
  year    = {2016},
  doi     = {10.1074/jbc.m115.695916},
  pmid    = {26663083},
  url     = {https://doi.org/10.1074/jbc.m115.695916}
}

@article{benilova2014-25253695,
  author  = {Benilova, I. and Gallardo, R. and Ungureanu, A. A. and Castillo Cano, V. and Snellinx, A. and Ramakers, M. and Bartic, C. and Rousseau, F. and others},
  title   = {{The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m114.599027},
  pmid    = {25253695},
  url     = {https://doi.org/10.1074/jbc.m114.599027}
}

@article{buggiaprevot2008-18263584,
  author  = {Buggia-Prevot, V. and Sevalle, J. and Rossner, S. and Checler, F.},
  title   = {{NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m706579200},
  pmid    = {18263584},
  url     = {https://doi.org/10.1074/jbc.m706579200}
}

@article{kostylev2015-26018073,
  author  = {Kostylev, M. A. and Kaufman, A. C. and Nygaard, H. B. and Patel, P. and Haas, L. T. and Gunther, E. C. and Vortmeyer, A. and Strittmatter, S. M.},
  title   = {{Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.643577},
  pmid    = {26018073},
  url     = {https://doi.org/10.1074/jbc.m115.643577}
}

@article{griffin1998-9880042,
  author  = {Griffin, W. S. and Sheng, J. G. and McKenzie, J. E. and Royston, M. C. and Gentleman, S. M. and Brumback, R. A. and Cork, L. C. and Del Bigio, M. R. and others},
  title   = {{Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis}},
  journal = {Neurobiology of aging},
  year    = {1998},
  doi     = {10.1016/s0197-4580(98)00074-8},
  pmid    = {9880042},
  url     = {https://doi.org/10.1016/s0197-4580(98)00074-8}
}

@article{benowitz1989-2591522,
  author  = {Benowitz, L. I. and Rodriguez, W. and Paskevich, P. and Mufson, E. J. and Schenk, D. and Neve, R. L.},
  title   = {{The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects}},
  journal = {Experimental neurology},
  year    = {1989},
  doi     = {10.1016/0014-4886(89)90156-8},
  pmid    = {2591522},
  url     = {https://doi.org/10.1016/0014-4886(89)90156-8}
}

@article{mcphie2003-12890786,
  author  = {McPhie, D. L. and Coopersmith, R. and Hines-Peralta, A. and Chen, Y. and Ivins, K. J. and Manly, S. P. and Kozlowski, M. R. and Neve, K. A. and others},
  title   = {{DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2003},
  doi     = {10.1523/jneurosci.23-17-06914.2003},
  pmid    = {12890786},
  url     = {https://doi.org/10.1523/jneurosci.23-17-06914.2003}
}

@article{ho2012-22606286,
  author  = {Ho, Y. S. and Yang, X. and Yeung, S. C. and Chiu, K. and Lau, C. F. and Tsang, A. W. and Mak, J. C. and Chang, R. C.},
  title   = {{Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0036752},
  pmid    = {22606286},
  url     = {https://doi.org/10.1371/journal.pone.0036752}
}

@article{hoe2009-19164281,
  author  = {Hoe, H. S. and Fu, Z. and Makarova, A. and Lee, J. Y. and Lu, C. and Feng, L. and Pajoohesh-Ganji, A. and Matsuoka, Y. and others},
  title   = {{The effects of amyloid precursor protein on postsynaptic composition and activity}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m900141200},
  pmid    = {19164281},
  url     = {https://doi.org/10.1074/jbc.m900141200}
}

@article{wallon2012-22475797,
  author  = {Wallon, D. and Rousseau, S. and Rovelet-Lecrux, A. and Quillard-Muraine, M. and Guyant-Maréchal, L. and Martinaud, O. and Pariente, J. and Puel, M. and others},
  title   = {{The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2012},
  doi     = {10.3233/jad-2012-120172},
  pmid    = {22475797},
  url     = {https://doi.org/10.3233/jad-2012-120172}
}

@article{lourenco2009-19148186,
  author  = {Lourenço, F. C. and Galvan, V. and Fombonne, J. and Corset, V. and Llambi, F. and Müller, U. and Bredesen, D. E. and Mehlen, P.},
  title   = {{Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production}},
  journal = {Cell death and differentiation},
  year    = {2009},
  doi     = {10.1038/cdd.2008.191},
  pmid    = {19148186},
  url     = {https://doi.org/10.1038/cdd.2008.191}
}

@article{snider2005-16344340,
  author  = {Snider, B. J. and Norton, J. and Coats, M. A. and Chakraverty, S. and Hou, C. E. and Jervis, R. and Lendon, C. L. and Goate, A. M. and others},
  title   = {{Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life}},
  journal = {Archives of neurology},
  year    = {2005},
  doi     = {10.1001/archneur.62.12.1821},
  pmid    = {16344340},
  url     = {https://doi.org/10.1001/archneur.62.12.1821}
}

@article{basun2008-18413473,
  author  = {Basun, H. and Bogdanovic, N. and Ingelsson, M. and Almkvist, O. and Näslund, J. and Axelman, K. and Bird, T. D. and Nochlin, D. and others},
  title   = {{Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.4.499},
  pmid    = {18413473},
  url     = {https://doi.org/10.1001/archneur.65.4.499}
}

@article{lu2025-41277110,
  author  = {Lu, Jiayi and Di Florio, Damian Nicolas and Boya, Patricia and Maday, Sandra and Springer, Wolfdieter and Chu, Charleen T.},
  title   = {{Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2581217},
  pmid    = {41277110},
  url     = {https://doi.org/10.1080/15548627.2025.2581217}
}

@article{armstrong2021-33180114,
  author  = {Armstrong, G. W. and Kim, L. A. and Vingopoulos, F. and Park, J. Y. and Garg, I. and Kasetty, M. and Silverman, R. F. and Zeng, R. and others},
  title   = {{Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms}},
  journal = {JAMA ophthalmology},
  year    = {2021},
  doi     = {10.1001/jamaophthalmol.2020.4909},
  pmid    = {33180114},
  url     = {https://doi.org/10.1001/jamaophthalmol.2020.4909}
}

@article{reinhardt2018-29358714,
  author  = {Reinhardt, S. and Stoye, N. and Luderer, M. and Kiefer, F. and Schmitt, U. and Lieb, K. and Endres, K.},
  title   = {{Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks}},
  journal = {Scientific reports},
  year    = {2018},
  doi     = {10.1038/s41598-018-19577-7},
  pmid    = {29358714},
  url     = {https://doi.org/10.1038/s41598-018-19577-7}
}

@article{vangiau2019-31557888,
  author  = {Van Giau, Vo and Bagyinszky, Eva and Youn, Young Chul and An, Seong Soo A and Kim, SangYun},
  title   = {{APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease}},
  journal = {International journal of molecular sciences},
  year    = {2019},
  doi     = {10.3390/ijms20194757},
  pmid    = {31557888},
  url     = {https://doi.org/10.3390/ijms20194757}
}

@article{vangiau2019-31182772,
  author  = {Van Giau, Vo and Bagyinszky, Eva and Yang, Young Soon and Youn, Young Chul and An, Seong Soo A and Kim, Sang Yun},
  title   = {{Genetic analyses of early-onset Alzheimer's disease using next generation sequencing}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-44848-2},
  pmid    = {31182772},
  url     = {https://doi.org/10.1038/s41598-019-44848-2}
}

@article{yang2022-36362122,
  author  = {Yang, YoungSoon and Bagyinszky, Eva and An, Seong Soo A and Kim, SangYun},
  title   = {{PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms232113331},
  pmid    = {36362122},
  url     = {https://doi.org/10.3390/ijms232113331}
}

@article{shim2022-35328387,
  author  = {Shim, Kyu-Hwan and Kang, Min-Ju and Bae, Heewon and Kim, Danyeong and Park, Jiwon and An, Seong-Soo A and Jeong, Da-Eun},
  title   = {{A Possible Pathogenic PSEN2 Gly56Ser Mutation in a Korean Patient with Early-Onset Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23062967},
  pmid    = {35328387},
  url     = {https://doi.org/10.3390/ijms23062967}
}

@article{lleo2001-11723295,
  author  = {Lleó, A and Blesa, R and Gendre, J and Castellví, M and Pastor, P and Queralt, R and Oliva, R},
  title   = {{A novel presenilin 2 gene mutation (D439A) in a patient with early-onset Alzheimer's disease}},
  journal = {Neurology},
  year    = {2001},
  doi     = {10.1212/wnl.57.10.1926},
  pmid    = {11723295},
  url     = {https://doi.org/10.1212/wnl.57.10.1926}
}

@article{zhou2020-32579498,
  author  = {Zhou, Jiajia and Chen, Yi and Meng, Fanxia and Zhang, Kan and Liu, Xiaoyan and Peng, Guoping},
  title   = {{Presenilin 1 and APP Gene Mutations in Early-Onset AD Families from a Southeast Region of China}},
  journal = {Current Alzheimer research},
  year    = {2020},
  doi     = {10.2174/1567205017666200624195809},
  pmid    = {32579498},
  url     = {https://doi.org/10.2174/1567205017666200624195809}
}

@article{rudenskaya2023-37994898,
  author  = {Rudenskaya, G E and Petukhova, M S and Zabnenkova, V V and Cherevatova, T B and Ryzhkova, O P},
  title   = {{[Early-onset familial Alzheimer's disease with spastic paraparesis associated with PSEN1 gene]}},
  journal = {Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova},
  year    = {2023},
  doi     = {10.17116/jnevro2023123111120},
  pmid    = {37994898},
  url     = {https://doi.org/10.17116/jnevro2023123111120}
}

@article{portet2003-14581682,
  author  = {Portet, F and Dauvilliers, Y and Campion, D and Raux, G and Hauw, J J and Lyon-Caen, O and Camu, W and Touchon, J},
  title   = {{Very early onset AD with a de novo mutation in the presenilin 1 gene (Met 233 Leu)}},
  journal = {Neurology},
  year    = {2003},
  doi     = {10.1212/01.wnl.0000086811.39675.79},
  pmid    = {14581682},
  url     = {https://doi.org/10.1212/01.wnl.0000086811.39675.79}
}

@article{krstic2013-23183882,
  author  = {Krstic, D. and Knuesel, I.},
  title   = {{Deciphering the mechanism underlying late-onset Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2013},
  doi     = {10.1038/nrneurol.2012.236},
  pmid    = {23183882},
  url     = {https://doi.org/10.1038/nrneurol.2012.236}
}

@article{hoyer2004-15094078,
  author  = {Hoyer, S.},
  title   = {{Glucose metabolism and insulin receptor signal transduction in Alzheimer disease}},
  journal = {European journal of pharmacology},
  year    = {2004},
  doi     = {10.1016/j.ejphar.2004.02.049},
  pmid    = {15094078},
  url     = {https://doi.org/10.1016/j.ejphar.2004.02.049}
}

@article{li1997-9258260,
  author  = {Li, S. and Mallory, M. and Alford, M. and Tanaka, S. and Masliah, E.},
  title   = {{Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1997},
  doi     = {10.1097/00005072-199708000-00008},
  pmid    = {9258260},
  url     = {https://doi.org/10.1097/00005072-199708000-00008}
}

@article{weidemann2002-11851430,
  author  = {Weidemann, A. and Eggert, S. and Reinhard, F. B. and Vogel, M. and Paliga, K. and Baier, G. and Masters, C. L. and Beyreuther, K. and others},
  title   = {{A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing}},
  journal = {Biochemistry},
  year    = {2002},
  doi     = {10.1021/bi015794o},
  pmid    = {11851430},
  url     = {https://doi.org/10.1021/bi015794o}
}

@article{wang2006-16364207,
  author  = {Wang, R. and Yan, H. and Tang, X. C.},
  title   = {{Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine}},
  journal = {Acta pharmacologica Sinica},
  year    = {2006},
  doi     = {10.1111/j.1745-7254.2006.00255.x},
  pmid    = {16364207},
  url     = {https://doi.org/10.1111/j.1745-7254.2006.00255.x}
}

@article{ning2008-18566467,
  author  = {Ning, A. and Cui, J. and To, E. and Ashe, K. H. and Matsubara, J.},
  title   = {{Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease}},
  journal = {Investigative ophthalmology \& visual science},
  year    = {2008},
  doi     = {10.1167/iovs.08-1849},
  pmid    = {18566467},
  url     = {https://doi.org/10.1167/iovs.08-1849}
}

@article{boissonneault2009-18986979,
  author  = {Boissonneault, V. and Plante, I. and Rivest, S. and Provost, P.},
  title   = {{MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m807530200},
  pmid    = {18986979},
  url     = {https://doi.org/10.1074/jbc.m807530200}
}

@article{westmark2007-17298186,
  author  = {Westmark, C. J. and Malter, J. S.},
  title   = {{FMRP mediates mGluR5-dependent translation of amyloid precursor protein}},
  journal = {PLoS biology},
  year    = {2007},
  doi     = {10.1371/journal.pbio.0050052},
  pmid    = {17298186},
  url     = {https://doi.org/10.1371/journal.pbio.0050052}
}

@article{muller2012-22355794,
  author  = {Müller, U. C. and Zheng, H.},
  title   = {{Physiological functions of APP family proteins}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
  doi     = {10.1101/cshperspect.a006288},
  pmid    = {22355794},
  url     = {https://doi.org/10.1101/cshperspect.a006288}
}

@article{blasko1999-9872930,
  author  = {Blasko, I. and Marx, F. and Steiner, E. and Hartmann, T. and Grubeck-Loebenstein, B.},
  title   = {{TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {1999},
  doi     = {10.1096/fasebj.13.1.63},
  pmid    = {9872930},
  url     = {https://doi.org/10.1096/fasebj.13.1.63}
}

@article{zhu2014-25336656,
  author  = {Zhu, Y. and Shan, X. and Yuzwa, S. A. and Vocadlo, D. J.},
  title   = {{The emerging link between O-GlcNAc and Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.r114.601351},
  pmid    = {25336656},
  url     = {https://doi.org/10.1074/jbc.r114.601351}
}

@article{gordon2002-11822882,
  author  = {Gordon, M. N. and Holcomb, L. A. and Jantzen, P. T. and DiCarlo, G. and Wilcock, D. and Boyett, K. W. and Connor, K. and Melachrino, J. and others},
  title   = {{Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse}},
  journal = {Experimental neurology},
  year    = {2002},
  doi     = {10.1006/exnr.2001.7754},
  pmid    = {11822882},
  url     = {https://doi.org/10.1006/exnr.2001.7754}
}

@article{ermekova1997-9407065,
  author  = {Ermekova, K. S. and Zambrano, N. and Linn, H. and Minopoli, G. and Gertler, F. and Russo, T. and Sudol, M.},
  title   = {{The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled}},
  journal = {The Journal of biological chemistry},
  year    = {1997},
  doi     = {10.1074/jbc.272.52.32869},
  pmid    = {9407065},
  url     = {https://doi.org/10.1074/jbc.272.52.32869}
}

@article{nelson2007-17431506,
  author  = {Nelson, O. and Tu, H. and Lei, T. and Bentahir, M. and de Strooper, B. and Bezprozvanny, I.},
  title   = {{Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1}},
  journal = {The Journal of clinical investigation},
  year    = {2007},
  doi     = {10.1172/jci30447},
  pmid    = {17431506},
  url     = {https://doi.org/10.1172/jci30447}
}

@article{muller2008-18603345,
  author  = {Müller, T. and Meyer, H. E. and Egensperger, R. and Marcus, K.},
  title   = {{The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease}},
  journal = {Progress in neurobiology},
  year    = {2008},
  doi     = {10.1016/j.pneurobio.2008.05.002},
  pmid    = {18603345},
  url     = {https://doi.org/10.1016/j.pneurobio.2008.05.002}
}

@article{bird2008-18414205,
  author  = {Bird, T. D.},
  title   = {{Genetic aspects of Alzheimer disease}},
  journal = {Genetics in medicine : official journal of the American College of Medical Genetics},
  year    = {2008},
  doi     = {10.1097/gim.0b013e31816b64dc},
  pmid    = {18414205},
  url     = {https://doi.org/10.1097/gim.0b013e31816b64dc}
}

@article{nalivaeva2013-23684647,
  author  = {Nalivaeva, N. N. and Turner, A. J.},
  title   = {{The amyloid precursor protein: a biochemical enigma in brain development, function and disease}},
  journal = {FEBS letters},
  year    = {2013},
  doi     = {10.1016/j.febslet.2013.05.010},
  pmid    = {23684647},
  url     = {https://doi.org/10.1016/j.febslet.2013.05.010}
}

@article{gu2009-19240035,
  author  = {Gu, Z. and Liu, W. and Yan, Z.},
  title   = {{beta-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m806508200},
  pmid    = {19240035},
  url     = {https://doi.org/10.1074/jbc.m806508200}
}

@article{lu2010-20460993,
  author  = {Lu, Y. and Wu, X. and Dong, Y. and Xu, Z. and Zhang, Y. and Xie, Z.},
  title   = {{Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice}},
  journal = {Anesthesiology},
  year    = {2010},
  doi     = {10.1097/aln.0b013e3181d94de1},
  pmid    = {20460993},
  url     = {https://doi.org/10.1097/aln.0b013e3181d94de1}
}

@article{brugg1995-7708769,
  author  = {Brugg, B. and Dubreuil, Y. L. and Huber, G. and Wollman, E. E. and Delhaye-Bouchaud, N. and Mariani, J.},
  title   = {{Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.7.3032},
  pmid    = {7708769},
  url     = {https://doi.org/10.1073/pnas.92.7.3032}
}

@article{cataldo1990-2350688,
  author  = {Cataldo, A. M. and Thayer, C. Y. and Bird, E. D. and Wheelock, T. R. and Nixon, R. A.},
  title   = {{Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin}},
  journal = {Brain research},
  year    = {1990},
  doi     = {10.1016/0006-8993(90)90456-l},
  pmid    = {2350688},
  url     = {https://doi.org/10.1016/0006-8993(90)90456-l}
}

@article{donnelly2008-18086681,
  author  = {Donnelly, P. S. and Caragounis, A. and Du, T. and Laughton, K. M. and Volitakis, I. and Cherny, R. A. and Sharples, R. A. and Hill, A. F. and others},
  title   = {{Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m705957200},
  pmid    = {18086681},
  url     = {https://doi.org/10.1074/jbc.m705957200}
}

@article{li2006-17186461,
  author  = {Li, D. and Parks, S. B. and Kushner, J. D. and Nauman, D. and Burgess, D. and Ludwigsen, S. and Partain, J. and Nixon, R. R. and others},
  title   = {{Mutations of presenilin genes in dilated cardiomyopathy and heart failure}},
  journal = {American journal of human genetics},
  year    = {2006},
  doi     = {10.1086/509900},
  pmid    = {17186461},
  url     = {https://doi.org/10.1086/509900}
}

@article{wolf1995-7876266,
  author  = {Wolf, B. A. and Wertkin, A. M. and Jolly, Y. C. and Yasuda, R. P. and Wolfe, B. B. and Konrad, R. J. and Manning, D. and Ravi, S. and others},
  title   = {{Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells}},
  journal = {The Journal of biological chemistry},
  year    = {1995},
  doi     = {10.1074/jbc.270.9.4916},
  pmid    = {7876266},
  url     = {https://doi.org/10.1074/jbc.270.9.4916}
}

@article{hitt2012-22988240,
  author  = {Hitt, B. and Riordan, S. M. and Kukreja, L. and Eimer, W. A. and Rajapaksha, T. W. and Vassar, R.},
  title   = {{β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.415505},
  pmid    = {22988240},
  url     = {https://doi.org/10.1074/jbc.m112.415505}
}

@article{matsuda2005-15983050,
  author  = {Matsuda, S. and Giliberto, L. and Matsuda, Y. and Davies, P. and McGowan, E. and Pickford, F. and Ghiso, J. and Frangione, B. and others},
  title   = {{The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.c500217200},
  pmid    = {15983050},
  url     = {https://doi.org/10.1074/jbc.c500217200}
}

@article{xu1995-7559474,
  author  = {Xu, H. and Greengard, P. and Gandy, S.},
  title   = {{Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {1995},
  doi     = {10.1074/jbc.270.40.23243},
  pmid    = {7559474},
  url     = {https://doi.org/10.1074/jbc.270.40.23243}
}

@article{darochasouto2011-21487307,
  author  = {DaRocha-Souto, B. and Scotton, T. C. and Coma, M. and Serrano-Pozo, A. and Hashimoto, T. and Serenó, L. and Rodríguez, M. and Sánchez, B. and others},
  title   = {{Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2011},
  doi     = {10.1097/nen.0b013e318217a118},
  pmid    = {21487307},
  url     = {https://doi.org/10.1097/nen.0b013e318217a118}
}

@article{li2014-24644038,
  author  = {Li, J. G. and Chu, J. and Barrero, C. and Merali, S. and Praticò, D.},
  title   = {{Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles}},
  journal = {Annals of neurology},
  year    = {2014},
  doi     = {10.1002/ana.24145},
  pmid    = {24644038},
  url     = {https://doi.org/10.1002/ana.24145}
}

@article{maesako2012-22563077,
  author  = {Maesako, M. and Uemura, K. and Kubota, M. and Kuzuya, A. and Sasaki, K. and Hayashida, N. and Asada-Utsugi, M. and Watanabe, K. and others},
  title   = {{Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.367011},
  pmid    = {22563077},
  url     = {https://doi.org/10.1074/jbc.m112.367011}
}

@article{bien2012-22879596,
  author  = {Bien, J. and Jefferson, T. and Causević, M. and Jumpertz, T. and Munter, L. and Multhaup, G. and Weggen, S. and Becker-Pauly, C. and others},
  title   = {{The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.395608},
  pmid    = {22879596},
  url     = {https://doi.org/10.1074/jbc.m112.395608}
}

@article{fedeli2019-30892128,
  author  = {Fedeli, C. and Filadi, R. and Rossi, A. and Mammucari, C. and Pizzo, P.},
  title   = {{PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis}},
  journal = {Autophagy},
  year    = {2019},
  doi     = {10.1080/15548627.2019.1596489},
  pmid    = {30892128},
  url     = {https://doi.org/10.1080/15548627.2019.1596489}
}

@article{irwin2013-23885714,
  author  = {Irwin, D. J. and Cohen, T. J. and Grossman, M. and Arnold, S. E. and McCarty-Wood, E. and Van Deerlin, V. M. and Lee, V. M. and Trojanowski, J. Q.},
  title   = {{Acetylated tau neuropathology in sporadic and hereditary tauopathies}},
  journal = {The American journal of pathology},
  year    = {2013},
  doi     = {10.1016/j.ajpath.2013.04.025},
  pmid    = {23885714},
  url     = {https://doi.org/10.1016/j.ajpath.2013.04.025}
}

@article{lee1995-7644542,
  author  = {Lee, R. K. and Wurtman, R. J. and Cox, A. J. and Nitsch, R. M.},
  title   = {{Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.17.8083},
  pmid    = {7644542},
  url     = {https://doi.org/10.1073/pnas.92.17.8083}
}

@article{olsson2014-24225948,
  author  = {Olsson, F. and Schmidt, S. and Althoff, V. and Munter, L. M. and Jin, S. and Rosqvist, S. and Lendahl, U. and Multhaup, G. and others},
  title   = {{Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m113.498246},
  pmid    = {24225948},
  url     = {https://doi.org/10.1074/jbc.m113.498246}
}

@article{steiner2018-31225454,
  author  = {Steiner, H. and Fukumori, A. and Tagami, S. and Okochi, M.},
  title   = {{Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase}},
  journal = {Cell stress},
  year    = {2018},
  doi     = {10.15698/cst2018.11.162},
  pmid    = {31225454},
  url     = {https://doi.org/10.15698/cst2018.11.162}
}

@article{demontgolfier2019-30571552,
  author  = {de Montgolfier, O. and Pinçon, A. and Pouliot, P. and Gillis, M. A. and Bishop, J. and Sled, J. G. and Villeneuve, L. and Ferland, G. and others},
  title   = {{High Systolic Blood Pressure Induces Cerebral Microvascular Endothelial Dysfunction, Neurovascular Unit Damage, and Cognitive Decline in Mice}},
  journal = {Hypertension (Dallas, Tex. : 1979)},
  year    = {2019},
  doi     = {10.1161/hypertensionaha.118.12048},
  pmid    = {30571552},
  url     = {https://doi.org/10.1161/hypertensionaha.118.12048}
}

@article{delay2011-21982160,
  author  = {Delay, C. and Calon, F. and Mathews, P. and Hébert, S. S.},
  title   = {{Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function}},
  journal = {Molecular neurodegeneration},
  year    = {2011},
  doi     = {10.1186/1750-1326-6-70},
  pmid    = {21982160},
  url     = {https://doi.org/10.1186/1750-1326-6-70}
}

@article{rosenberg2016-27135718,
  author  = {Rosenberg, R. N. and Lambracht-Washington, D. and Yu, G. and Xia, W.},
  title   = {{Genomics of Alzheimer Disease: A Review}},
  journal = {JAMA neurology},
  year    = {2016},
  doi     = {10.1001/jamaneurol.2016.0301},
  pmid    = {27135718},
  url     = {https://doi.org/10.1001/jamaneurol.2016.0301}
}

@article{hung1992-1409654,
  author  = {Hung, A. Y. and Koo, E. H. and Haass, C. and Selkoe, D. J.},
  title   = {{Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.20.9439},
  pmid    = {1409654},
  url     = {https://doi.org/10.1073/pnas.89.20.9439}
}

@article{chami2012-22654105,
  author  = {Chami, L. and Buggia-Prévot, V. and Duplan, E. and Del Prete, D. and Chami, M. and Peyron, J. F. and Checler, F.},
  title   = {{Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m111.333054},
  pmid    = {22654105},
  url     = {https://doi.org/10.1074/jbc.m111.333054}
}

@article{arai1990-1690426,
  author  = {Arai, H. and Lee, V. M. and Otvos, L. and Greenberg, B. D. and Lowery, D. E. and Sharma, S. K. and Schmidt, M. L. and Trojanowski, J. Q.},
  title   = {{Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1990},
  doi     = {10.1073/pnas.87.6.2249},
  pmid    = {1690426},
  url     = {https://doi.org/10.1073/pnas.87.6.2249}
}

@article{wang2012-23024364,
  author  = {Wang, C. and Sun, B. and Zhou, Y. and Grubb, A. and Gan, L.},
  title   = {{Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.371641},
  pmid    = {23024364},
  url     = {https://doi.org/10.1074/jbc.m112.371641}
}

@article{jankowsky2007-17556372,
  author  = {Jankowsky, J. L. and Younkin, L. H. and Gonzales, V. and Fadale, D. J. and Slunt, H. H. and Lester, H. A. and Younkin, S. G. and Borchelt, D. R.},
  title   = {{Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m611050200},
  pmid    = {17556372},
  url     = {https://doi.org/10.1074/jbc.m611050200}
}

@article{graffradford2014-25332445,
  author  = {Graff-Radford, N. R.},
  title   = {{Alzheimer CSF biomarkers may be misleading in normal-pressure hydrocephalus}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000916},
  pmid    = {25332445},
  url     = {https://doi.org/10.1212/wnl.0000000000000916}
}

@article{barberocamps2014-24815354,
  author  = {Barbero-Camps, E. and Fernández, A. and Baulies, A. and Martinez, L. and Fernández-Checa, J. C. and Colell, A.},
  title   = {{Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking}},
  journal = {The American journal of pathology},
  year    = {2014},
  doi     = {10.1016/j.ajpath.2014.03.014},
  pmid    = {24815354},
  url     = {https://doi.org/10.1016/j.ajpath.2014.03.014}
}

@article{varvel2009-19907078,
  author  = {Varvel, N. H. and Bhaskar, K. and Kounnas, M. Z. and Wagner, S. L. and Yang, Y. and Lamb, B. T. and Herrup, K.},
  title   = {{NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2009},
  doi     = {10.1172/jci39716},
  pmid    = {19907078},
  url     = {https://doi.org/10.1172/jci39716}
}

@article{teter2019-30951849,
  author  = {Teter, B. and Morihara, T. and Lim, G. P. and Chu, T. and Jones, M. R. and Zuo, X. and Paul, R. M. and Frautschy, S. A. and others},
  title   = {{Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis}},
  journal = {Neurobiology of disease},
  year    = {2019},
  doi     = {10.1016/j.nbd.2019.02.015},
  pmid    = {30951849},
  url     = {https://doi.org/10.1016/j.nbd.2019.02.015}
}

@article{brodbeck2011-21454574,
  author  = {Brodbeck, J. and McGuire, J. and Liu, Z. and Meyer-Franke, A. and Balestra, M. E. and Jeong, D. E. and Pleiss, M. and McComas, C. and others},
  title   = {{Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.217380},
  pmid    = {21454574},
  url     = {https://doi.org/10.1074/jbc.m110.217380}
}

@article{hou2017-27105872,
  author  = {Hou, Y. and Song, H. and Croteau, D. L. and Akbari, M. and Bohr, V. A.},
  title   = {{Genome instability in Alzheimer disease}},
  journal = {Mechanisms of ageing and development},
  year    = {2017},
  doi     = {10.1016/j.mad.2016.04.005},
  pmid    = {27105872},
  url     = {https://doi.org/10.1016/j.mad.2016.04.005}
}

@article{multhaup2015-26296890,
  author  = {Multhaup, G. and Huber, O. and Buée, L. and Galas, M. C.},
  title   = {{Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.r115.677211},
  pmid    = {26296890},
  url     = {https://doi.org/10.1074/jbc.r115.677211}
}

@article{rosenberg1997-9041854,
  author  = {Rosenberg, R. N. and Baskin, F. and Fosmire, J. A. and Risser, R. and Adams, P. and Svetlik, D. and Honig, L. S. and Cullum, C. M. and others},
  title   = {{Altered amyloid protein processing in platelets of patients with Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {1997},
  doi     = {10.1001/archneur.1997.00550140019007},
  pmid    = {9041854},
  url     = {https://doi.org/10.1001/archneur.1997.00550140019007}
}

@article{nordvall2025-40054389,
  author  = {Nordvall, Gunnar and Yan, Ping and Agholme, Lotta and Lundkvist, Johan and Sandin, Johan and Biverstål, Henrik and Winblad, Bengt G. and Zetterberg, Henrik and others},
  title   = {{γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice}},
  journal = {Journal of Pharmacology and Experimental Therapeutics},
  year    = {2025},
  doi     = {10.1016/j.jpet.2025.103400},
  pmid    = {40054389},
  url     = {https://doi.org/10.1016/j.jpet.2025.103400}
}

@article{albanus2025-40737431,
  author  = {Albanus, Ricardo D’Oliveira and Finan, Gina M. and Brase, Logan and Sweeney, Nicholas and Kim, Tae Yeon and Chen, Shuo and Ryoo, Yeonsu and others},
  title   = {{Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease}},
  journal = {Science Translational Medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.adx0027},
  pmid    = {40737431},
  url     = {https://doi.org/10.1126/scitranslmed.adx0027}
}

@article{castelot2025-40336092,
  author  = {Castelot, Romain and Zaréa, Aline and Wallon, David and Rovelet‐Lecrux, Anne and Schramm, Catherine and Quillard‐Muraine, Muriel and Beaume, Anne and Blanc, Frédéric and others},
  title   = {{Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01748-0},
  pmid    = {40336092},
  url     = {https://doi.org/10.1186/s13195-025-01748-0}
}

@article{xiao2021-34220489,
  author  = {Xiao, Xuewen and Liu, Hui and Liu, Xixi and Zhang, Weiwei and Zhang, Sizhe and Jiao, Bin},
  title   = {{APP, PSEN1, and PSEN2 Variants in Alzheimer's Disease: Systematic Re-evaluation According to ACMG Guidelines}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.695808},
  pmid    = {34220489},
  url     = {https://doi.org/10.3389/fnagi.2021.695808}
}

@article{course2023-35949106,
  author  = {Course, Meredith M and Gudsnuk, Kathryn and Keene, C Dirk and Bird, Thomas D and Jayadev, Suman and Valdmanis, Paul N},
  title   = {{Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awac294},
  pmid    = {35949106},
  url     = {https://doi.org/10.1093/brain/awac294}
}

@article{piaceri2020-32328830,
  author  = {Piaceri, I and Chiari, A and Galli, C and Bagnoli, S and Ferrari, C and Saavedra, S Trujillo and Molinari, M A and Vinceti, G and others},
  title   = {{Incomplete penetrance in familial Alzheimer's disease with PSEN1 Ala260Gly mutation}},
  journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
  year    = {2020},
  doi     = {10.1007/s10072-020-04421-6},
  pmid    = {32328830},
  url     = {https://doi.org/10.1007/s10072-020-04421-6}
}

@article{muchnik2015-26166204,
  author  = {Muchnik, Carolina and Olivar, Natividad and Dalmasso, María Carolina and Azurmendi, Pablo Javier and Liberczuk, Cynthia and Morelli, Laura and Brusco, Luis Ignacio},
  title   = {{Identification of PSEN2 mutation p.N141I in Argentine pedigrees with early-onset familial Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2015.06.011},
  pmid    = {26166204},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.06.011}
}

@article{vangiau2019-31391004,
  author  = {Van Giau, Vo and Pyun, Jung-Min and Suh, Jeewon and Bagyinszky, Eva and An, Seong Soo A and Kim, Sang Yun},
  title   = {{A pathogenic PSEN1 Trp165Cys mutation associated with early-onset Alzheimer's disease}},
  journal = {BMC neurology},
  year    = {2019},
  doi     = {10.1186/s12883-019-1419-y},
  pmid    = {31391004},
  url     = {https://doi.org/10.1186/s12883-019-1419-y}
}

@article{vangiau2018-30104866,
  author  = {Van Giau, Vo and Pyun, Jung-Min and Bagyinszky, Eva and An, Seong Soo A and Kim, SangYun},
  title   = {{A pathogenic PSEN2 p.His169Asn mutation associated with early-onset Alzheimer's disease}},
  journal = {Clinical interventions in aging},
  year    = {2018},
  doi     = {10.2147/cia.s170374},
  pmid    = {30104866},
  url     = {https://doi.org/10.2147/cia.s170374}
}

@article{willumsen2022-34319632,
  author  = {Willumsen, Nanet and Poole, Teresa and Nicholas, Jennifer M and Fox, Nick C and Ryan, Natalie S and Lashley, Tammaryn},
  title   = {{Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer's disease}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2022},
  doi     = {10.1111/bpa.13009},
  pmid    = {34319632},
  url     = {https://doi.org/10.1111/bpa.13009}
}

@article{bernardi2009-18314228,
  author  = {Bernardi, Livia and Tomaino, Carmine and Anfossi, Maria and Gallo, Maura and Geracitano, Silvana and Costanzo, Angela and Colao, Rosanna and Puccio, Gianfranco and others},
  title   = {{Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2009},
  doi     = {10.1016/j.neurobiolaging.2008.01.005},
  pmid    = {18314228},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2008.01.005}
}

@article{kane2000-10804202,
  author  = {Kane, M. D. and Lipinski, W. J. and Callahan, M. J. and Bian, F. and Durham, R. A. and Schwarz, R. D. and Roher, A. E. and Walker, L. C.},
  title   = {{Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2000},
  doi     = {10.1523/jneurosci.20-10-03606.2000},
  pmid    = {10804202},
  url     = {https://doi.org/10.1523/jneurosci.20-10-03606.2000}
}

@article{mandelkow2003-14643379,
  author  = {Mandelkow, E. M. and Stamer, K. and Vogel, R. and Thies, E. and Mandelkow, E.},
  title   = {{Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses}},
  journal = {Neurobiology of aging},
  year    = {2003},
  doi     = {10.1016/j.neurobiolaging.2003.04.007},
  pmid    = {14643379},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2003.04.007}
}

@article{yu1998-9632714,
  author  = {Yu, G. and Chen, F. and Levesque, G. and Nishimura, M. and Zhang, D. M. and Levesque, L. and Rogaeva, E. and Xu, D. and others},
  title   = {{The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin}},
  journal = {The Journal of biological chemistry},
  year    = {1998},
  doi     = {10.1074/jbc.273.26.16470},
  pmid    = {9632714},
  url     = {https://doi.org/10.1074/jbc.273.26.16470}
}

@article{fuso2005-15607954,
  author  = {Fuso, A. and Seminara, L. and Cavallaro, R. A. and D'Anselmi, F. and Scarpa, S.},
  title   = {{S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production}},
  journal = {Molecular and cellular neurosciences},
  year    = {2005},
  doi     = {10.1016/j.mcn.2004.09.007},
  pmid    = {15607954},
  url     = {https://doi.org/10.1016/j.mcn.2004.09.007}
}

@article{moran1995-7777509,
  author  = {Moran, P. M. and Higgins, L. S. and Cordell, B. and Moser, P. C.},
  title   = {{Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.12.5341},
  pmid    = {7777509},
  url     = {https://doi.org/10.1073/pnas.92.12.5341}
}

@article{mcconlogue2007-17616527,
  author  = {McConlogue, L. and Buttini, M. and Anderson, J. P. and Brigham, E. F. and Chen, K. S. and Freedman, S. B. and Games, D. and Johnson-Wood, K. and others},
  title   = {{Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m611687200},
  pmid    = {17616527},
  url     = {https://doi.org/10.1074/jbc.m611687200}
}

@article{oltersdorf1990-1968460,
  author  = {Oltersdorf, T. and Ward, P. J. and Henriksson, T. and Beattie, E. C. and Neve, R. and Lieberburg, I. and Fritz, L. C.},
  title   = {{The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway}},
  journal = {The Journal of biological chemistry},
  year    = {1990},
  doi     = {10.1016/s0021-9258(19)39590-0},
  pmid    = {1968460},
  url     = {https://doi.org/10.1016/s0021-9258(19)39590-0}
}

@article{li2007-17456849,
  author  = {Li, Z. G. and Zhang, W. and Sima, A. A.},
  title   = {{Alzheimer-like changes in rat models of spontaneous diabetes}},
  journal = {Diabetes},
  year    = {2007},
  doi     = {10.2337/db07-0171},
  pmid    = {17456849},
  url     = {https://doi.org/10.2337/db07-0171}
}

@article{schubert1991-1786532,
  author  = {Schubert, W. and Prior, R. and Weidemann, A. and Dircksen, H. and Multhaup, G. and Masters, C. L. and Beyreuther, K.},
  title   = {{Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites}},
  journal = {Brain research},
  year    = {1991},
  doi     = {10.1016/0006-8993(91)91532-6},
  pmid    = {1786532},
  url     = {https://doi.org/10.1016/0006-8993(91)91532-6}
}

@article{vilardo2010-20395292,
  author  = {Vilardo, E. and Barbato, C. and Ciotti, M. and Cogoni, C. and Ruberti, F.},
  title   = {{MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.112664},
  pmid    = {20395292},
  url     = {https://doi.org/10.1074/jbc.m110.112664}
}

@article{colciaghi2002-12080182,
  author  = {Colciaghi, F. and Borroni, B. and Pastorino, L. and Marcello, E. and Zimmermann, M. and Cattabeni, F. and Padovani, A. and Di Luca, M.},
  title   = {{[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients}},
  journal = {Molecular medicine (Cambridge, Mass.)},
  year    = {2002},
  doi     = {10.1007/bf03402076},
  pmid    = {12080182},
  url     = {https://doi.org/10.1007/bf03402076}
}

@article{he2005-15615712,
  author  = {He, X. and Li, F. and Chang, W. P. and Tang, J.},
  title   = {{GGA proteins mediate the recycling pathway of memapsin 2 (BACE)}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m411296200},
  pmid    = {15615712},
  url     = {https://doi.org/10.1074/jbc.m411296200}
}

@article{domingues2017-28317487,
  author  = {Domingues, C. and da Cruz E Silva, O. A. B. and Henriques, A. G.},
  title   = {{Impact of Cytokines and Chemokines on Alzheimer's Disease Neuropathological Hallmarks}},
  journal = {Current Alzheimer research},
  year    = {2017},
  doi     = {10.2174/1567205014666170317113606},
  pmid    = {28317487},
  url     = {https://doi.org/10.2174/1567205014666170317113606}
}

@article{rossjohn1999-10201399,
  author  = {Rossjohn, J. and Cappai, R. and Feil, S. C. and Henry, A. and McKinstry, W. J. and Galatis, D. and Hesse, L. and Multhaup, G. and others},
  title   = {{Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein}},
  journal = {Nature structural biology},
  year    = {1999},
  doi     = {10.1038/7562},
  pmid    = {10201399},
  url     = {https://doi.org/10.1038/7562}
}

@article{jankowsky2003-14692698,
  author  = {Jankowsky, J. L. and Xu, G. and Fromholt, D. and Gonzales, V. and Borchelt, D. R.},
  title   = {{Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2003},
  doi     = {10.1093/jnen/62.12.1220},
  pmid    = {14692698},
  url     = {https://doi.org/10.1093/jnen/62.12.1220}
}

@article{lim2001-11755007,
  author  = {Lim, G. P. and Yang, F. and Chu, T. and Gahtan, E. and Ubeda, O. and Beech, W. and Overmier, J. B. and Hsiao-Ashec, K. and others},
  title   = {{Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2001},
  doi     = {10.1016/s0197-4580(01)00299-8},
  pmid    = {11755007},
  url     = {https://doi.org/10.1016/s0197-4580(01)00299-8}
}

@article{hook2008-18184658,
  author  = {Hook, V. Y. and Kindy, M. and Hook, G.},
  title   = {{Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m708362200},
  pmid    = {18184658},
  url     = {https://doi.org/10.1074/jbc.m708362200}
}

@article{long2014-24352696,
  author  = {Long, J. M. and Ray, B. and Lahiri, D. K.},
  title   = {{MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m113.518241},
  pmid    = {24352696},
  url     = {https://doi.org/10.1074/jbc.m113.518241}
}

@article{schmidt2007-17855360,
  author  = {Schmidt, V. and Sporbert, A. and Rohe, M. and Reimer, T. and Rehm, A. and Andersen, O. M. and Willnow, T. E.},
  title   = {{SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m705073200},
  pmid    = {17855360},
  url     = {https://doi.org/10.1074/jbc.m705073200}
}

@article{nordstedt1993-8416966,
  author  = {Nordstedt, C. and Caporaso, G. L. and Thyberg, J. and Gandy, S. E. and Greengard, P.},
  title   = {{Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells}},
  journal = {The Journal of biological chemistry},
  year    = {1993},
  doi     = {10.1016/s0021-9258(18)54194-6},
  pmid    = {8416966},
  url     = {https://doi.org/10.1016/s0021-9258(18)54194-6}
}

@article{haining2012-23035126,
  author  = {Haining, E. J. and Yang, J. and Bailey, R. L. and Khan, K. and Collier, R. and Tsai, S. and Watson, S. P. and Frampton, J. and others},
  title   = {{The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.416503},
  pmid    = {23035126},
  url     = {https://doi.org/10.1074/jbc.m112.416503}
}

@article{caccamo2011-21266573,
  author  = {Caccamo, A. and Maldonado, M. A. and Majumder, S. and Medina, D. X. and Holbein, W. and Magrí, A. and Oddo, S.},
  title   = {{Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.180638},
  pmid    = {21266573},
  url     = {https://doi.org/10.1074/jbc.m110.180638}
}

@article{culbert2006-16774924,
  author  = {Culbert, A. A. and Skaper, S. D. and Howlett, D. R. and Evans, N. A. and Facci, L. and Soden, P. E. and Seymour, Z. M. and Guillot, F. and others},
  title   = {{MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m513646200},
  pmid    = {16774924},
  url     = {https://doi.org/10.1074/jbc.m513646200}
}

@article{maloney2014-25253696,
  author  = {Maloney, J. A. and Bainbridge, T. and Gustafson, A. and Zhang, S. and Kyauk, R. and Steiner, P. and van der Brug, M. and Liu, Y. and others},
  title   = {{Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m114.589069},
  pmid    = {25253696},
  url     = {https://doi.org/10.1074/jbc.m114.589069}
}

@article{sabo2003-12843239,
  author  = {Sabo, S. L. and Ikin, A. F. and Buxbaum, J. D. and Greengard, P.},
  title   = {{The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2003},
  doi     = {10.1523/jneurosci.23-13-05407.2003},
  pmid    = {12843239},
  url     = {https://doi.org/10.1523/jneurosci.23-13-05407.2003}
}

@article{leroy2012-23026200,
  author  = {Leroy, K. and Ando, K. and Laporte, V. and Dedecker, R. and Suain, V. and Authelet, M. and Héraud, C. and Pierrot, N. and others},
  title   = {{Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice}},
  journal = {The American journal of pathology},
  year    = {2012},
  doi     = {10.1016/j.ajpath.2012.08.012},
  pmid    = {23026200},
  url     = {https://doi.org/10.1016/j.ajpath.2012.08.012}
}

@article{mori2001-11487052,
  author  = {Mori, T. and Paris, D. and Town, T. and Rojiani, A. M. and Sparks, D. L. and Delledonne, A. and Crawford, F. and Abdullah, L. I. and others},
  title   = {{Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2001},
  doi     = {10.1093/jnen/60.8.778},
  pmid    = {11487052},
  url     = {https://doi.org/10.1093/jnen/60.8.778}
}

@article{thanopoulou2010-21076037,
  author  = {Thanopoulou, K. and Fragkouli, A. and Stylianopoulou, F. and Georgopoulos, S.},
  title   = {{Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2010},
  doi     = {10.1073/pnas.1005888107},
  pmid    = {21076037},
  url     = {https://doi.org/10.1073/pnas.1005888107}
}

@article{fraser1994-7966323,
  author  = {Fraser, P. E. and McLachlan, D. R. and Surewicz, W. K. and Mizzen, C. A. and Snow, A. D. and Nguyen, J. T. and Kirschner, D. A.},
  title   = {{Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues}},
  journal = {Journal of molecular biology},
  year    = {1994},
  doi     = {10.1006/jmbi.1994.1704},
  pmid    = {7966323},
  url     = {https://doi.org/10.1006/jmbi.1994.1704}
}

@article{cataldo2004-15330337,
  author  = {Cataldo, A. M. and Peterhoff, C. M. and Schmidt, S. D. and Terio, N. B. and Duff, K. and Beard, M. and Mathews, P. M. and Nixon, R. A.},
  title   = {{Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2004},
  doi     = {10.1093/jnen/63.8.821},
  pmid    = {15330337},
  url     = {https://doi.org/10.1093/jnen/63.8.821}
}

@article{kienlencampard2008-18201969,
  author  = {Kienlen-Campard, P. and Tasiaux, B. and Van Hees, J. and Li, M. and Huysseune, S. and Sato, T. and Fei, J. Z. and Aimoto, S. and others},
  title   = {{Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m707142200},
  pmid    = {18201969},
  url     = {https://doi.org/10.1074/jbc.m707142200}
}

@article{vetrivel2006-16930451,
  author  = {Vetrivel, K. S. and Zhang, Y. W. and Xu, H. and Thinakaran, G.},
  title   = {{Pathological and physiological functions of presenilins}},
  journal = {Molecular neurodegeneration},
  year    = {2006},
  doi     = {10.1186/1750-1326-1-4},
  pmid    = {16930451},
  url     = {https://doi.org/10.1186/1750-1326-1-4}
}

@article{fang2012-22015470,
  author  = {Fang, F. and Chen, X. and Huang, T. and Lue, L. F. and Luddy, J. S. and Yan, S. S.},
  title   = {{Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model}},
  journal = {Biochimica et biophysica acta},
  year    = {2012},
  doi     = {10.1016/j.bbadis.2011.10.004},
  pmid    = {22015470},
  url     = {https://doi.org/10.1016/j.bbadis.2011.10.004}
}

@article{cole2005-15718241,
  author  = {Cole, S. L. and Grudzien, A. and Manhart, I. O. and Kelly, B. L. and Oakley, H. and Vassar, R.},
  title   = {{Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m413895200},
  pmid    = {15718241},
  url     = {https://doi.org/10.1074/jbc.m413895200}
}

@article{areagomez2016-27235807,
  author  = {Area-Gomez, E. and Schon, E. A.},
  title   = {{Mitochondria-associated ER membranes and Alzheimer disease}},
  journal = {Current opinion in genetics \& development},
  year    = {2016},
  doi     = {10.1016/j.gde.2016.04.006},
  pmid    = {27235807},
  url     = {https://doi.org/10.1016/j.gde.2016.04.006}
}

@article{tienari1997-9108116,
  author  = {Tienari, P. J. and Ida, N. and Ikonen, E. and Simons, M. and Weidemann, A. and Multhaup, G. and Masters, C. L. and Dotti, C. G. and others},
  title   = {{Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.8.4125},
  pmid    = {9108116},
  url     = {https://doi.org/10.1073/pnas.94.8.4125}
}

@article{roher1993-8229002,
  author  = {Roher, A. E. and Palmer, K. C. and Yurewicz, E. C. and Ball, M. J. and Greenberg, B. D.},
  title   = {{Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue}},
  journal = {Journal of neurochemistry},
  year    = {1993},
  doi     = {10.1111/j.1471-4159.1993.tb09834.x},
  pmid    = {8229002},
  url     = {https://doi.org/10.1111/j.1471-4159.1993.tb09834.x}
}

@article{wan2011-21034809,
  author  = {Wan, L. and Nie, G. and Zhang, J. and Luo, Y. and Zhang, P. and Zhang, Z. and Zhao, B.},
  title   = {{β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease}},
  journal = {Free radical biology \& medicine},
  year    = {2011},
  doi     = {10.1016/j.freeradbiomed.2010.10.707},
  pmid    = {21034809},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2010.10.707}
}

@article{shinohara2010-20472556,
  author  = {Shinohara, M. and Sato, N. and Kurinami, H. and Takeuchi, D. and Takeda, S. and Shimamura, M. and Yamashita, T. and Uchiyama, Y. and others},
  title   = {{Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.102277},
  pmid    = {20472556},
  url     = {https://doi.org/10.1074/jbc.m110.102277}
}

@article{kitazume2010-20952385,
  author  = {Kitazume, S. and Tachida, Y. and Kato, M. and Yamaguchi, Y. and Honda, T. and Hashimoto, Y. and Wada, Y. and Saito, T. and others},
  title   = {{Brain endothelial cells produce amyloid beta from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.144626},
  pmid    = {20952385},
  url     = {https://doi.org/10.1074/jbc.m110.144626}
}

@article{zhang2005-15711015,
  author  = {Zhang, Y. W. and Luo, W. J. and Wang, H. and Lin, P. and Vetrivel, K. S. and Liao, F. and Li, F. and Wong, P. C. and others},
  title   = {{Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m409467200},
  pmid    = {15711015},
  url     = {https://doi.org/10.1074/jbc.m409467200}
}

@article{pierrot2013-23554170,
  author  = {Pierrot, N. and Tyteca, D. and D'auria, L. and Dewachter, I. and Gailly, P. and Hendrickx, A. and Tasiaux, B. and Haylani, L. E. and others},
  title   = {{Amyloid precursor protein controls cholesterol turnover needed for neuronal activity}},
  journal = {EMBO molecular medicine},
  year    = {2013},
  doi     = {10.1002/emmm.201202215},
  pmid    = {23554170},
  url     = {https://doi.org/10.1002/emmm.201202215}
}

@article{delarasse2011-21081501,
  author  = {Delarasse, C. and Auger, R. and Gonnord, P. and Fontaine, B. and Kanellopoulos, J. M.},
  title   = {{The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.200618},
  pmid    = {21081501},
  url     = {https://doi.org/10.1074/jbc.m110.200618}
}

@article{kinoshita2003-12888553,
  author  = {Kinoshita, A. and Shah, T. and Tangredi, M. M. and Strickland, D. K. and Hyman, B. T.},
  title   = {{The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65}},
  journal = {The Journal of biological chemistry},
  year    = {2003},
  doi     = {10.1074/jbc.m306403200},
  pmid    = {12888553},
  url     = {https://doi.org/10.1074/jbc.m306403200}
}

@article{sadowski2004-15198121,
  author  = {Sadowski, M. and Pankiewicz, J. and Scholtzova, H. and Ji, Y. and Quartermain, D. and Jensen, C. H. and Duff, K. and Nixon, R. A. and others},
  title   = {{Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2004},
  doi     = {10.1093/jnen/63.5.418},
  pmid    = {15198121},
  url     = {https://doi.org/10.1093/jnen/63.5.418}
}

@article{pozdnyakov2013-23396974,
  author  = {Pozdnyakov, N. and Murrey, H. E. and Crump, C. J. and Pettersson, M. and Ballard, T. E. and Am Ende, C. W. and Ahn, K. and Li, Y. M. and others},
  title   = {{γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m112.398602},
  pmid    = {23396974},
  url     = {https://doi.org/10.1074/jbc.m112.398602}
}

@article{winkler2012-22532566,
  author  = {Winkler, E. and Kamp, F. and Scheuring, J. and Ebke, A. and Fukumori, A. and Steiner, H.},
  title   = {{Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.356659},
  pmid    = {22532566},
  url     = {https://doi.org/10.1074/jbc.m112.356659}
}

@article{yagi2025-40143815,
  author  = {Yagi, Hitomi and Boeck, Myriam and Neilsen, Katherine and Yang, Jay and Ko, Minji and Tomita, Yohei and Negishi, Kazuno and Fu, Zhongjie and others},
  title   = {{Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes—Brief Report}},
  journal = {Arteriosclerosis Thrombosis and Vascular Biology},
  year    = {2025},
  doi     = {10.1161/atvbaha.124.321809},
  pmid    = {40143815},
  url     = {https://doi.org/10.1161/atvbaha.124.321809}
}

@article{borroni2001-11255448,
  author  = {Borroni, B. and Colciaghi, F. and Pastorino, L. and Pettenati, C. and Cottini, E. and Rozzini, L. and Monastero, R. and Lenzi, G. L. and others},
  title   = {{Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment}},
  journal = {Archives of neurology},
  year    = {2001},
  doi     = {10.1001/archneur.58.3.442},
  pmid    = {11255448},
  url     = {https://doi.org/10.1001/archneur.58.3.442}
}

@article{schedinweiss2014-24279329,
  author  = {Schedin-Weiss, S. and Winblad, B. and Tjernberg, L. O.},
  title   = {{The role of protein glycosylation in Alzheimer disease}},
  journal = {The FEBS journal},
  year    = {2014},
  doi     = {10.1111/febs.12590},
  pmid    = {24279329},
  url     = {https://doi.org/10.1111/febs.12590}
}

@article{apelt2001-11245811,
  author  = {Apelt, J. and Schliebs, R.},
  title   = {{Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology}},
  journal = {Brain research},
  year    = {2001},
  doi     = {10.1016/s0006-8993(00)03176-0},
  pmid    = {11245811},
  url     = {https://doi.org/10.1016/s0006-8993(00)03176-0}
}

@article{greeve2004-15102905,
  author  = {Greeve, I. and Kretzschmar, D. and Tschäpe, J. A. and Beyn, A. and Brellinger, C. and Schweizer, M. and Nitsch, R. M. and Reifegerste, R.},
  title   = {{Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2004},
  doi     = {10.1523/jneurosci.0283-04.2004},
  pmid    = {15102905},
  url     = {https://doi.org/10.1523/jneurosci.0283-04.2004}
}

@article{jung2009-19652386,
  author  = {Jung, H. A. and Min, B. S. and Yokozawa, T. and Lee, J. H. and Kim, Y. S. and Choi, J. S.},
  title   = {{Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids}},
  journal = {Biological \& pharmaceutical bulletin},
  year    = {2009},
  doi     = {10.1248/bpb.32.1433},
  pmid    = {19652386},
  url     = {https://doi.org/10.1248/bpb.32.1433}
}

@article{cataldo1991-1837142,
  author  = {Cataldo, A. M. and Paskevich, P. A. and Kominami, E. and Nixon, R. A.},
  title   = {{Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1991},
  doi     = {10.1073/pnas.88.24.10998},
  pmid    = {1837142},
  url     = {https://doi.org/10.1073/pnas.88.24.10998}
}

@article{tamboli2010-20876579,
  author  = {Tamboli, I. Y. and Barth, E. and Christian, L. and Siepmann, M. and Kumar, S. and Singh, S. and Tolksdorf, K. and Heneka, M. T. and others},
  title   = {{Statins promote the degradation of extracellular amyloid beta-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.149468},
  pmid    = {20876579},
  url     = {https://doi.org/10.1074/jbc.m110.149468}
}

@article{irizarry2004-15717023,
  author  = {Irizarry, M. C.},
  title   = {{Biomarkers of Alzheimer disease in plasma}},
  journal = {NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2004},
  doi     = {10.1602/neurorx.1.2.226},
  pmid    = {15717023},
  url     = {https://doi.org/10.1602/neurorx.1.2.226}
}

@article{fang2012-22178568,
  author  = {Fang, M. and Wang, J. and Zhang, X. and Geng, Y. and Hu, Z. and Rudd, J. A. and Ling, S. and Chen, W. and others},
  title   = {{The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease}},
  journal = {Toxicology letters},
  year    = {2012},
  doi     = {10.1016/j.toxlet.2011.11.032},
  pmid    = {22178568},
  url     = {https://doi.org/10.1016/j.toxlet.2011.11.032}
}

@article{suzuki1994-8131745,
  author  = {Suzuki, T. and Oishi, M. and Marshak, D. R. and Czernik, A. J. and Nairn, A. C. and Greengard, P.},
  title   = {{Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein}},
  journal = {The EMBO journal},
  year    = {1994},
  doi     = {10.1002/j.1460-2075.1994.tb06360.x},
  pmid    = {8131745},
  url     = {https://doi.org/10.1002/j.1460-2075.1994.tb06360.x}
}

@article{gowing1994-8157623,
  author  = {Gowing, E. and Roher, A. E. and Woods, A. S. and Cotter, R. J. and Chaney, M. and Little, S. P. and Ball, M. J.},
  title   = {{Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {1994},
  doi     = {10.1016/s0021-9258(19)78080-6},
  pmid    = {8157623},
  url     = {https://doi.org/10.1016/s0021-9258(19)78080-6}
}

@article{yasojima2001-11689168,
  author  = {Yasojima, K. and McGeer, E. G. and McGeer, P. L.},
  title   = {{Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain}},
  journal = {Brain research},
  year    = {2001},
  doi     = {10.1016/s0006-8993(01)03008-6},
  pmid    = {11689168},
  url     = {https://doi.org/10.1016/s0006-8993(01)03008-6}
}

@article{jahangard2020-32625049,
  author  = {Jahangard, Y. and Monfared, H. and Moradi, A. and Zare, M. and Mirnajafi-Zadeh, J. and Mowla, S. J.},
  title   = {{Therapeutic Effects of Transplanted Exosomes Containing miR-29b to a Rat Model of Alzheimer's Disease}},
  journal = {Frontiers in neuroscience},
  year    = {2020},
  doi     = {10.3389/fnins.2020.00564},
  pmid    = {32625049},
  url     = {https://doi.org/10.3389/fnins.2020.00564}
}

@article{levy2001-11202179,
  author  = {Levy, E. and Sastre, M. and Kumar, A. and Gallo, G. and Piccardo, P. and Ghetti, B. and Tagliavini, F.},
  title   = {{Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2001},
  doi     = {10.1093/jnen/60.1.94},
  pmid    = {11202179},
  url     = {https://doi.org/10.1093/jnen/60.1.94}
}

@article{wilson1999-10446803,
  author  = {Wilson, C. A. and Doms, R. W. and Lee, V. M.},
  title   = {{Intracellular APP processing and A beta production in Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1999},
  doi     = {10.1097/00005072-199908000-00001},
  pmid    = {10446803},
  url     = {https://doi.org/10.1097/00005072-199908000-00001}
}

@article{belyaev2009-19057576,
  author  = {Belyaev, N. D. and Nalivaeva, N. N. and Makova, N. Z. and Turner, A. J.},
  title   = {{Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease}},
  journal = {EMBO reports},
  year    = {2009},
  doi     = {10.1038/embor.2008.222},
  pmid    = {19057576},
  url     = {https://doi.org/10.1038/embor.2008.222}
}

@article{kuhn2007-17307738,
  author  = {Kuhn, P. H. and Marjaux, E. and Imhof, A. and De Strooper, B. and Haass, C. and Lichtenthaler, S. F.},
  title   = {{Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m700356200},
  pmid    = {17307738},
  url     = {https://doi.org/10.1074/jbc.m700356200}
}

@article{liu2017-28003341,
  author  = {Liu, Q. and Chen, Y. and Shen, C. and Xiao, Y. and Wang, Y. and Liu, Z. and Liu, X.},
  title   = {{Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2017},
  doi     = {10.1096/fj.201601071r},
  pmid    = {28003341},
  url     = {https://doi.org/10.1096/fj.201601071r}
}

@article{yao2017-28330719,
  author  = {Yao, Z. and Yang, W. and Gao, Z. and Jia, P.},
  title   = {{Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease}},
  journal = {Neuroscience letters},
  year    = {2017},
  doi     = {10.1016/j.neulet.2017.03.027},
  pmid    = {28330719},
  url     = {https://doi.org/10.1016/j.neulet.2017.03.027}
}

@article{viayna2014-24568372,
  author  = {Viayna, E. and Sola, I. and Bartolini, M. and De Simone, A. and Tapia-Rojas, C. and Serrano, F. G. and Sabaté, R. and Juárez-Jiménez, J. and others},
  title   = {{Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents}},
  journal = {Journal of medicinal chemistry},
  year    = {2014},
  doi     = {10.1021/jm401824w},
  pmid    = {24568372},
  url     = {https://doi.org/10.1021/jm401824w}
}

@article{martin2005-15734684,
  author  = {Martin, G. M.},
  title   = {{Genetic modulation of senescent phenotypes in Homo sapiens}},
  journal = {Cell},
  year    = {2005},
  doi     = {10.1016/j.cell.2005.01.031},
  pmid    = {15734684},
  url     = {https://doi.org/10.1016/j.cell.2005.01.031}
}

@article{gralle2009-19336403,
  author  = {Gralle, M. and Botelho, M. G. and Wouters, F. S.},
  title   = {{Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m808755200},
  pmid    = {19336403},
  url     = {https://doi.org/10.1074/jbc.m808755200}
}

@article{tolia2006-16844686,
  author  = {Tolia, A. and Chávez-Gutiérrez, L. and De Strooper, B.},
  title   = {{Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m604997200},
  pmid    = {16844686},
  url     = {https://doi.org/10.1074/jbc.m604997200}
}

@article{takeda2013-23561508,
  author  = {Takeda, S. and Sato, N. and Ikimura, K. and Nishino, H. and Rakugi, H. and Morishita, R.},
  title   = {{Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.02.010},
  pmid    = {23561508},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.02.010}
}

@article{masliah1998-9825941,
  author  = {Masliah, E. and Mallory, M. and Alford, M. and Tanaka, S. and Hansen, L. A.},
  title   = {{Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1998},
  doi     = {10.1097/00005072-199811000-00007},
  pmid    = {9825941},
  url     = {https://doi.org/10.1097/00005072-199811000-00007}
}

@article{pensalfini2014-25092575,
  author  = {Pensalfini, A. and Albay, R. and Rasool, S. and Wu, J. W. and Hatami, A. and Arai, H. and Margol, L. and Milton, S. and others},
  title   = {{Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques}},
  journal = {Neurobiology of disease},
  year    = {2014},
  doi     = {10.1016/j.nbd.2014.07.011},
  pmid    = {25092575},
  url     = {https://doi.org/10.1016/j.nbd.2014.07.011}
}

@article{camden2005-15778502,
  author  = {Camden, J. M. and Schrader, A. M. and Camden, R. E. and González, F. A. and Erb, L. and Seye, C. I. and Weisman, G. A.},
  title   = {{P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m500219200},
  pmid    = {15778502},
  url     = {https://doi.org/10.1074/jbc.m500219200}
}

@article{greenfield2002-11823458,
  author  = {Greenfield, J. P. and Leung, L. W. and Cai, D. and Kaasik, K. and Gross, R. S. and Rodriguez-Boulan, E. and Greengard, P. and Xu, H.},
  title   = {{Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis}},
  journal = {The Journal of biological chemistry},
  year    = {2002},
  doi     = {10.1074/jbc.m110009200},
  pmid    = {11823458},
  url     = {https://doi.org/10.1074/jbc.m110009200}
}

@article{willnow2013-23813966,
  author  = {Willnow, T. E. and Andersen, O. M.},
  title   = {{Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease}},
  journal = {Journal of cell science},
  year    = {2013},
  doi     = {10.1242/jcs.125393},
  pmid    = {23813966},
  url     = {https://doi.org/10.1242/jcs.125393}
}

@article{park2006-16452662,
  author  = {Park, J. H. and Gimbel, D. A. and GrandPre, T. and Lee, J. K. and Kim, J. E. and Li, W. and Lee, D. H. and Strittmatter, S. M.},
  title   = {{Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.3291-05.2006},
  pmid    = {16452662},
  url     = {https://doi.org/10.1523/jneurosci.3291-05.2006}
}

@article{ringman2012-22232349,
  author  = {Ringman, J. M. and Schulman, H. and Becker, C. and Jones, T. and Bai, Y. and Immermann, F. and Cole, G. and Sokolow, S. and others},
  title   = {{Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations}},
  journal = {Archives of neurology},
  year    = {2012},
  doi     = {10.1001/archneurol.2011.642},
  pmid    = {22232349},
  url     = {https://doi.org/10.1001/archneurol.2011.642}
}

@article{fraser1993-8515277,
  author  = {Fraser, P. E. and Nguyen, J. T. and McLachlan, D. R. and Abraham, C. R. and Kirschner, D. A.},
  title   = {{Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro}},
  journal = {Journal of neurochemistry},
  year    = {1993},
  doi     = {10.1111/j.1471-4159.1993.tb03568.x},
  pmid    = {8515277},
  url     = {https://doi.org/10.1111/j.1471-4159.1993.tb03568.x}
}

@article{guo2019-31370707,
  author  = {Guo, Y. and Wei, X. and Yan, H. and Qin, Y. and Yan, S. and Liu, J. and Zhao, Y. and Jiang, F. and others},
  title   = {{TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900992r},
  pmid    = {31370707},
  url     = {https://doi.org/10.1096/fj.201900992r}
}

@article{tampellini2007-17468102,
  author  = {Tampellini, D. and Magrané, J. and Takahashi, R. H. and Li, F. and Lin, M. T. and Almeida, C. G. and Gouras, G. K.},
  title   = {{Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m700373200},
  pmid    = {17468102},
  url     = {https://doi.org/10.1074/jbc.m700373200}
}

@article{rosenblum2014-24210593,
  author  = {Rosenblum, W. I.},
  title   = {{Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.10.085},
  pmid    = {24210593},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.10.085}
}

@article{veereshwarayya2006-16887805,
  author  = {Veereshwarayya, V. and Kumar, P. and Rosen, K. M. and Mestril, R. and Querfurth, H. W.},
  title   = {{Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m602533200},
  pmid    = {16887805},
  url     = {https://doi.org/10.1074/jbc.m602533200}
}

@article{rogaev1997-9073509,
  author  = {Rogaev, E. I. and Sherrington, R. and Wu, C. and Levesque, G. and Liang, Y. and Rogaeva, E. A. and Ikeda, M. and Holman, K. and others},
  title   = {{Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease}},
  journal = {Genomics},
  year    = {1997},
  doi     = {10.1006/geno.1996.4523},
  pmid    = {9073509},
  url     = {https://doi.org/10.1006/geno.1996.4523}
}

@article{yin2007-17556361,
  author  = {Yin, Y. I. and Bassit, B. and Zhu, L. and Yang, X. and Wang, C. and Li, Y. M.},
  title   = {{gamma-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m704601200},
  pmid    = {17556361},
  url     = {https://doi.org/10.1074/jbc.m704601200}
}

@article{sotiropoulos2008-18691381,
  author  = {Sotiropoulos, I. and Catania, C. and Riedemann, T. and Fry, J. P. and Breen, K. C. and Michaelidis, T. M. and Almeida, O. F.},
  title   = {{Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2008.05613.x},
  pmid    = {18691381},
  url     = {https://doi.org/10.1111/j.1471-4159.2008.05613.x}
}

@article{angeletti2005-15722349,
  author  = {Angeletti, B. and Waldron, K. J. and Freeman, K. B. and Bawagan, H. and Hussain, I. and Miller, C. C. and Lau, K. F. and Tennant, M. E. and others},
  title   = {{BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m412034200},
  pmid    = {15722349},
  url     = {https://doi.org/10.1074/jbc.m412034200}
}

@article{etani2025-41261421,
  author  = {Etani, Hayato and Takatori, Sho and Wang, Wenbo and Omi, Jumpei and Amiya, Yusuke and Akahori, Aika and Watanabe, Hirotaka and Sonn, Iki and others},
  title   = {{Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01891-8},
  pmid    = {41261421},
  url     = {https://doi.org/10.1186/s13195-025-01891-8}
}

@article{mcnamara1998-9678319,
  author  = {McNamara, M. J. and Gomez-Isla, T. and Hyman, B. T.},
  title   = {{Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {1998},
  doi     = {10.1001/archneur.55.7.1001},
  pmid    = {9678319},
  url     = {https://doi.org/10.1001/archneur.55.7.1001}
}

@article{venegas2017-29293211,
  author  = {Venegas, C. and Kumar, S. and Franklin, B. S. and Dierkes, T. and Brinkschulte, R. and Tejera, D. and Vieira-Saecker, A. and Schwartz, S. and others},
  title   = {{Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease}},
  journal = {Nature},
  year    = {2017},
  doi     = {10.1038/nature25158},
  pmid    = {29293211},
  url     = {https://doi.org/10.1038/nature25158}
}

@article{graffradford2021-33609479,
  author  = {Graff-Radford, J. and Yong, K. X. X. and Apostolova, L. G. and Bouwman, F. H. and Carrillo, M. and Dickerson, B. C. and Rabinovici, G. D. and Schott, J. M. and others},
  title   = {{New insights into atypical Alzheimer's disease in the era of biomarkers}},
  journal = {The Lancet. Neurology},
  year    = {2021},
  doi     = {10.1016/s1474-4422(20)30440-3},
  pmid    = {33609479},
  url     = {https://doi.org/10.1016/s1474-4422(20)30440-3}
}

@article{erkert2024-38684238,
  author  = {Erkert, Lena and Gamez-Belmonte, Reyes and Kabisch, Melanie and Schödel, Lena and Patankar, Jay V and Gonzalez-Acera, Miguel and Mahapatro, Mousumi and Bao, Li-Li and others},
  title   = {{Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis}},
  journal = {Gut},
  year    = {2024},
  doi     = {10.1136/gutjnl-2023-331622},
  pmid    = {38684238},
  url     = {https://doi.org/10.1136/gutjnl-2023-331622}
}

@article{gao2019-30822634,
  author  = {Gao, Ying and Ren, Ru-Jing and Zhong, Zi-Lin and Dammer, Eric and Zhao, Qian-Hua and Shan, Shan and Zhou, Zheng and Li, Xia and others},
  title   = {{Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2019},
  doi     = {10.1016/j.neurobiolaging.2019.01.018},
  pmid    = {30822634},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2019.01.018}
}

@article{bagyinszky2024-39596030,
  author  = {Bagyinszky, Eva and An, Seong Soo A},
  title   = {{Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms252211959},
  pmid    = {39596030},
  url     = {https://doi.org/10.3390/ijms252211959}
}

@article{valdes2025-39754192,
  author  = {Valdes, Phoebe and Caldwell, Andrew B and Liu, Qing and Fitzgerald, Michael Q and Ramachandran, Srinivasan and Karch, Celeste M and Galasko, Douglas R and others},
  title   = {{Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-024-01659-6},
  pmid    = {39754192},
  url     = {https://doi.org/10.1186/s13195-024-01659-6}
}

@article{martinezfeduchi2024-38726308,
  author  = {Martinez-Feduchi, Paula and Jin, Peng and Yao, Bing},
  title   = {{Epigenetic modifications of DNA and RNA in Alzheimer's disease}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2024},
  doi     = {10.3389/fnmol.2024.1398026},
  pmid    = {38726308},
  url     = {https://doi.org/10.3389/fnmol.2024.1398026}
}

@article{marsh2025-39875235,
  author  = {Marsh, Jacob A and Huang, Guangming and Bowling, Kevin and Renton, Alan E and Ziegemeier, Ellen and Ball, Torri and Pottier, Cyril and Cruchaga, Carlos and others},
  title   = {{Evaluating pathogenicity of variants of unknown significance in APP, PSEN1, and PSEN2}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2025},
  doi     = {10.1016/j.neurot.2025.e00527},
  pmid    = {39875235},
  url     = {https://doi.org/10.1016/j.neurot.2025.e00527}
}

@article{castilloordonez2024-37843220,
  author  = {Castillo-Ordoñez, Willian Orlando and Cajas-Salazar, Nohelia and Velasco-Reyes, Mayra Alejandra},
  title   = {{Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents}},
  journal = {Neural regeneration research},
  year    = {2024},
  doi     = {10.4103/1673-5374.382232},
  pmid    = {37843220},
  url     = {https://doi.org/10.4103/1673-5374.382232}
}

@article{johnson2025-40518825,
  author  = {Johnson, Ian P and Peterson, Tia M and Gudsnuk, Kathryn and Keene, C Dirk and Bird, Thomas D and Jayadev, Suman and Valdmanis, Paul N and Course, Meredith M},
  title   = {{Presence of Alzheimer's disease variants in circular RNA of PSEN1 and PSEN2}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877251350112},
  pmid    = {40518825},
  url     = {https://doi.org/10.1177/13872877251350112}
}

@article{yan2024-39136994,
  author  = {Yan, Kuo and Zhang, Chen and Kang, Jongkyun and Montenegro, Paola and Shen, Jie},
  title   = {{Cortical neurodegeneration caused by Psen1 mutations is independent of Aβ}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2024},
  doi     = {10.1073/pnas.2409343121},
  pmid    = {39136994},
  url     = {https://doi.org/10.1073/pnas.2409343121}
}

@article{li2025-41068782,
  author  = {Li, Zuguang and Zhang, Juan and Liu, Zhiqiang and Yu, Lu and Yang, Chunqing and Zhang, Luoman and Xiang, Zhigao and Hu, Feng and others},
  title   = {{Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00895-0},
  pmid    = {41068782},
  url     = {https://doi.org/10.1186/s13024-025-00895-0}
}

@article{ting2014-24413619,
  author  = {Ting, Simon Kang Seng and Benzinger, Tammie and Kepe, Vladimir and Fagan, Anne and Coppola, Giovanni and Porter, Verna and Hecimovic, Silva and Chakraverty, Suma and others},
  title   = {{A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-131844},
  pmid    = {24413619},
  url     = {https://doi.org/10.3233/jad-131844}
}

@article{mir2024-38213663,
  author  = {Mir, Asif and Kamran, Zainab and Iqbal, Wajid},
  title   = {{Orchestration of Genetic Alterations in PSEN1 and PSEN2 Genes in Development of Alzheimer's Disease through Computational Analysis}},
  journal = {Global medical genetics},
  year    = {2024},
  doi     = {10.1055/s-0043-1777849},
  pmid    = {38213663},
  url     = {https://doi.org/10.1055/s-0043-1777849}
}

@article{bai2015-26623517,
  author  = {Bai, Xiao‐chen and Rajendra, Eeson and Yang, Guanghui and Shi, Yigong and Scheres, Sjors H. W.},
  title   = {{Sampling the conformational space of the catalytic subunit of human γ-secretase}},
  journal = {eLife},
  year    = {2015},
  doi     = {10.7554/elife.11182},
  pmid    = {26623517},
  url     = {https://doi.org/10.7554/elife.11182}
}

@article{roberts2012-22121980,
  author  = {Roberts, B. R. and Ryan, T. M. and Bush, A. I. and Masters, C. L. and Duce, J. A.},
  title   = {{The role of metallobiology and amyloid-β peptides in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2012},
  doi     = {10.1111/j.1471-4159.2011.07500.x},
  pmid    = {22121980},
  url     = {https://doi.org/10.1111/j.1471-4159.2011.07500.x}
}

@article{knauer1992-1502155,
  author  = {Knauer, M. F. and Soreghan, B. and Burdick, D. and Kosmoski, J. and Glabe, C. G.},
  title   = {{Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.16.7437},
  pmid    = {1502155},
  url     = {https://doi.org/10.1073/pnas.89.16.7437}
}

@article{wertkin1993-8415732,
  author  = {Wertkin, A. M. and Turner, R. S. and Pleasure, S. J. and Golde, T. E. and Younkin, S. G. and Trojanowski, J. Q. and Lee, V. M.},
  title   = {{Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.20.9513},
  pmid    = {8415732},
  url     = {https://doi.org/10.1073/pnas.90.20.9513}
}

@article{lukiw2008-19022980,
  author  = {Lukiw, W. J. and Bazan, N. G.},
  title   = {{Docosahexaenoic acid and the aging brain}},
  journal = {The Journal of nutrition},
  year    = {2008},
  doi     = {10.3945/jn.108.096016},
  pmid    = {19022980},
  url     = {https://doi.org/10.3945/jn.108.096016}
}

@article{kienlencampard2002-11861655,
  author  = {Kienlen-Campard, P. and Miolet, S. and Tasiaux, B. and Octave, J. N.},
  title   = {{Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis}},
  journal = {The Journal of biological chemistry},
  year    = {2002},
  doi     = {10.1074/jbc.m200887200},
  pmid    = {11861655},
  url     = {https://doi.org/10.1074/jbc.m200887200}
}

@article{blanch2016-26776077,
  author  = {Blanch, M. and Mosquera, J. L. and Ansoleaga, B. and Ferrer, I. and Barrachina, M.},
  title   = {{Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease-Related Pathology and in Parkinson Disease}},
  journal = {The American journal of pathology},
  year    = {2016},
  doi     = {10.1016/j.ajpath.2015.10.004},
  pmid    = {26776077},
  url     = {https://doi.org/10.1016/j.ajpath.2015.10.004}
}

@article{mandel2008-19040558,
  author  = {Mandel, S. A. and Amit, T. and Weinreb, O. and Reznichenko, L. and Youdim, M. B.},
  title   = {{Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases}},
  journal = {CNS neuroscience \& therapeutics},
  year    = {2008},
  doi     = {10.1111/j.1755-5949.2008.00060.x},
  pmid    = {19040558},
  url     = {https://doi.org/10.1111/j.1755-5949.2008.00060.x}
}

@article{yuzwa2014-25344697,
  author  = {Yuzwa, S. A. and Shan, X. and Jones, B. A. and Zhao, G. and Woodward, M. L. and Li, X. and Zhu, Y. and McEachern, E. J. and others},
  title   = {{Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice}},
  journal = {Molecular neurodegeneration},
  year    = {2014},
  doi     = {10.1186/1750-1326-9-42},
  pmid    = {25344697},
  url     = {https://doi.org/10.1186/1750-1326-9-42}
}

@article{wilson2017-27978767,
  author  = {Wilson, M. R. and Zoubeidi, A.},
  title   = {{Clusterin as a therapeutic target}},
  journal = {Expert opinion on therapeutic targets},
  year    = {2017},
  doi     = {10.1080/14728222.2017.1267142},
  pmid    = {27978767},
  url     = {https://doi.org/10.1080/14728222.2017.1267142}
}

@article{lefterov2010-20739292,
  author  = {Lefterov, I. and Fitz, N. F. and Cronican, A. A. and Fogg, A. and Lefterov, P. and Kodali, R. and Wetzel, R. and Koldamova, R.},
  title   = {{Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.127738},
  pmid    = {20739292},
  url     = {https://doi.org/10.1074/jbc.m110.127738}
}

@article{miravalle2005-16086583,
  author  = {Miravalle, L. and Calero, M. and Takao, M. and Roher, A. E. and Ghetti, B. and Vidal, R.},
  title   = {{Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques}},
  journal = {Biochemistry},
  year    = {2005},
  doi     = {10.1021/bi0508237},
  pmid    = {16086583},
  url     = {https://doi.org/10.1021/bi0508237}
}

@article{schellenberg1995-7567974,
  author  = {Schellenberg, G. D.},
  title   = {{Genetic dissection of Alzheimer disease, a heterogeneous disorder}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.19.8552},
  pmid    = {7567974},
  url     = {https://doi.org/10.1073/pnas.92.19.8552}
}

@article{young2012-22155432,
  author  = {Young, F. B. and Butland, S. L. and Sanders, S. S. and Sutton, L. M. and Hayden, M. R.},
  title   = {{Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases}},
  journal = {Progress in neurobiology},
  year    = {2012},
  doi     = {10.1016/j.pneurobio.2011.11.002},
  pmid    = {22155432},
  url     = {https://doi.org/10.1016/j.pneurobio.2011.11.002}
}

@article{zhao2013-23462268,
  author  = {Zhao, Y. and Bhattacharjee, S. and Jones, B. M. and Dua, P. and Alexandrov, P. N. and Hill, J. M. and Lukiw, W. J.},
  title   = {{Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a}},
  journal = {Neuroreport},
  year    = {2013},
  doi     = {10.1097/wnr.0b013e32835fb6b0},
  pmid    = {23462268},
  url     = {https://doi.org/10.1097/wnr.0b013e32835fb6b0}
}

@article{askanas1996-8577761,
  author  = {Askanas, V. and McFerrin, J. and Baqué, S. and Alvarez, R. B. and Sarkozi, E. and Engel, W. K.},
  title   = {{Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1996},
  doi     = {10.1073/pnas.93.3.1314},
  pmid    = {8577761},
  url     = {https://doi.org/10.1073/pnas.93.3.1314}
}

@article{mclaurin1998-9571042,
  author  = {McLaurin, J. and Franklin, T. and Chakrabartty, A. and Fraser, P. E.},
  title   = {{Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest}},
  journal = {Journal of molecular biology},
  year    = {1998},
  doi     = {10.1006/jmbi.1998.1677},
  pmid    = {9571042},
  url     = {https://doi.org/10.1006/jmbi.1998.1677}
}

@article{muller2007-17093061,
  author  = {Müller, T. and Concannon, C. G. and Ward, M. W. and Walsh, C. M. and Tirniceriu, A. L. and Tribl, F. and Kögel, D. and Prehn, J. H. and others},
  title   = {{Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)}},
  journal = {Molecular biology of the cell},
  year    = {2007},
  doi     = {10.1091/mbc.e06-04-0283},
  pmid    = {17093061},
  url     = {https://doi.org/10.1091/mbc.e06-04-0283}
}

@article{mei2010-20813165,
  author  = {Mei, X. and Ezan, P. and Giaume, C. and Koulakoff, A.},
  title   = {{Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice}},
  journal = {Neuroscience},
  year    = {2010},
  doi     = {10.1016/j.neuroscience.2010.08.001},
  pmid    = {20813165},
  url     = {https://doi.org/10.1016/j.neuroscience.2010.08.001}
}

@article{zhao2004-15485850,
  author  = {Zhao, G. and Mao, G. and Tan, J. and Dong, Y. and Cui, M. Z. and Kim, S. H. and Xu, X.},
  title   = {{Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2004},
  doi     = {10.1074/jbc.c400473200},
  pmid    = {15485850},
  url     = {https://doi.org/10.1074/jbc.c400473200}
}

@article{cheng2013-23546882,
  author  = {Cheng, C. and Li, W. and Zhang, Z. and Yoshimura, S. and Hao, Q. and Zhang, C. and Wang, Z.},
  title   = {{MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10)}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m112.381392},
  pmid    = {23546882},
  url     = {https://doi.org/10.1074/jbc.m112.381392}
}

@article{mouton2009-19699265,
  author  = {Mouton, P. R. and Chachich, M. E. and Quigley, C. and Spangler, E. and Ingram, D. K.},
  title   = {{Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice}},
  journal = {Neuroscience letters},
  year    = {2009},
  doi     = {10.1016/j.neulet.2009.08.038},
  pmid    = {19699265},
  url     = {https://doi.org/10.1016/j.neulet.2009.08.038}
}

@article{greenberg1994-8041753,
  author  = {Greenberg, S. M. and Koo, E. H. and Selkoe, D. J. and Qiu, W. Q. and Kosik, K. S.},
  title   = {{Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.15.7104},
  pmid    = {8041753},
  url     = {https://doi.org/10.1073/pnas.91.15.7104}
}

@article{scearcelevie2020-32612262,
  author  = {Scearce-Levie, K. and Sanchez, P. E. and Lewcock, J. W.},
  title   = {{Leveraging preclinical models for the development of Alzheimer disease therapeutics}},
  journal = {Nature reviews. Drug discovery},
  year    = {2020},
  doi     = {10.1038/s41573-020-0065-9},
  pmid    = {32612262},
  url     = {https://doi.org/10.1038/s41573-020-0065-9}
}

@article{catricala2012-22985434,
  author  = {Catricala, S. and Torti, M. and Ricevuti, G.},
  title   = {{Alzheimer disease and platelets: how's that relevant}},
  journal = {Immunity \& ageing : I \& A},
  year    = {2012},
  doi     = {10.1186/1742-4933-9-20},
  pmid    = {22985434},
  url     = {https://doi.org/10.1186/1742-4933-9-20}
}

@article{venkataramani2010-20145244,
  author  = {Venkataramani, V. and Rossner, C. and Iffland, L. and Schweyer, S. and Tamboli, I. Y. and Walter, J. and Wirths, O. and Bayer, T. A.},
  title   = {{Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m109.057836},
  pmid    = {20145244},
  url     = {https://doi.org/10.1074/jbc.m109.057836}
}

@article{zhou2015-25611954,
  author  = {Zhou, Q. and Wang, M. and Du, Y. and Zhang, W. and Bai, M. and Zhang, Z. and Li, Z. and Miao, J.},
  title   = {{Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24361},
  pmid    = {25611954},
  url     = {https://doi.org/10.1002/ana.24361}
}

@article{lane2004-15190239,
  author  = {Lane, R. M. and Kivipelto, M. and Greig, N. H.},
  title   = {{Acetylcholinesterase and its inhibition in Alzheimer disease}},
  journal = {Clinical neuropharmacology},
  year    = {2004},
  doi     = {10.1097/00002826-200405000-00011},
  pmid    = {15190239},
  url     = {https://doi.org/10.1097/00002826-200405000-00011}
}

@article{jeppsson2012-23048024,
  author  = {Jeppsson, F. and Eketjäll, S. and Janson, J. and Karlström, S. and Gustavsson, S. and Olsson, L. L. and Radesäter, A. C. and Ploeger, B. and others},
  title   = {{Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.409110},
  pmid    = {23048024},
  url     = {https://doi.org/10.1074/jbc.m112.409110}
}

@article{matsumura2014-24375443,
  author  = {Matsumura, N. and Takami, M. and Okochi, M. and Wada-Kakuda, S. and Fujiwara, H. and Tagami, S. and Funamoto, S. and Ihara, Y. and others},
  title   = {{γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m113.510131},
  pmid    = {24375443},
  url     = {https://doi.org/10.1074/jbc.m113.510131}
}

@article{kitazume2003-12473667,
  author  = {Kitazume, S. and Tachida, Y. and Oka, R. and Kotani, N. and Ogawa, K. and Suzuki, M. and Dohmae, N. and Takio, K. and others},
  title   = {{Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1)}},
  journal = {The Journal of biological chemistry},
  year    = {2003},
  doi     = {10.1074/jbc.m206262200},
  pmid    = {12473667},
  url     = {https://doi.org/10.1074/jbc.m206262200}
}

@article{parr2015-25384422,
  author  = {Parr, C. and Mirzaei, N. and Christian, M. and Sastre, M.},
  title   = {{Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2015},
  doi     = {10.1096/fj.14-253211},
  pmid    = {25384422},
  url     = {https://doi.org/10.1096/fj.14-253211}
}

@article{chen2014-23996345,
  author  = {Chen, Y. and Liang, Z. and Tian, Z. and Blanchard, J. and Dai, C. L. and Chalbot, S. and Iqbal, K. and Liu, F. and others},
  title   = {{Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice}},
  journal = {Molecular neurobiology},
  year    = {2014},
  doi     = {10.1007/s12035-013-8539-y},
  pmid    = {23996345},
  url     = {https://doi.org/10.1007/s12035-013-8539-y}
}

@article{fisette2012-22303960,
  author  = {Fisette, J. F. and Montagna, D. R. and Mihailescu, M. R. and Wolfe, M. S.},
  title   = {{A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing}},
  journal = {Journal of neurochemistry},
  year    = {2012},
  doi     = {10.1111/j.1471-4159.2012.07680.x},
  pmid    = {22303960},
  url     = {https://doi.org/10.1111/j.1471-4159.2012.07680.x}
}

@article{gouras1998-9798916,
  author  = {Gouras, G. K. and Xu, H. and Jovanovic, J. N. and Buxbaum, J. D. and Wang, R. and Greengard, P. and Relkin, N. R. and Gandy, S.},
  title   = {{Generation and regulation of beta-amyloid peptide variants by neurons}},
  journal = {Journal of neurochemistry},
  year    = {1998},
  doi     = {10.1046/j.1471-4159.1998.71051920.x},
  pmid    = {9798916},
  url     = {https://doi.org/10.1046/j.1471-4159.1998.71051920.x}
}

@article{gattaz1995-7893853,
  author  = {Gattaz, W. F. and Maras, A. and Cairns, N. J. and Levy, R. and Förstl, H.},
  title   = {{Decreased phospholipase A2 activity in Alzheimer brains}},
  journal = {Biological psychiatry},
  year    = {1995},
  doi     = {10.1016/0006-3223(94)00123-k},
  pmid    = {7893853},
  url     = {https://doi.org/10.1016/0006-3223(94)00123-k}
}