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% Source: https://alzhub.org/research?category=drug_development&score_min=30&score_max=49
% 500 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{whittington2022-35022306,
  author  = {Whittington, M. D. and Campbell, J. D. and Rind, D. and Fluetsch, N. and Lin, G. A. and Pearson, S. D.},
  title   = {{Cost-Effectiveness and Value-Based Pricing of Aducanumab for Patients With Early Alzheimer Disease}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000013314},
  pmid    = {35022306},
  url     = {https://doi.org/10.1212/wnl.0000000000013314}
}

@article{uhlmann2020-33199898,
  author  = {Uhlmann, R. E. and Rother, C. and Rasmussen, J. and Schelle, J. and Bergmann, C. and Ullrich Gavilanes, E. M. and Fritschi, S. K. and Buehler, A. and others},
  title   = {{Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life}},
  journal = {Nature neuroscience},
  year    = {2020},
  doi     = {10.1038/s41593-020-00737-w},
  pmid    = {33199898},
  url     = {https://doi.org/10.1038/s41593-020-00737-w}
}

@article{sveikata2022-34905943,
  author  = {Sveikata, L. and Charidimou, A. and Viswanathan, A.},
  title   = {{Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab}},
  journal = {Stroke},
  year    = {2022},
  doi     = {10.1161/strokeaha.121.036873},
  pmid    = {34905943},
  url     = {https://doi.org/10.1161/strokeaha.121.036873}
}

@article{alvarado2024-38181731,
  author  = {Alvarado, C. X. and Makarious, M. B. and Weller, C. A. and Vitale, D. and Koretsky, M. J. and Bandres-Ciga, S. and Iwaki, H. and Levine, K. and others},
  title   = {{omicSynth: An open multi-omic community resource for identifying druggable targets across neurodegenerative diseases}},
  journal = {American journal of human genetics},
  year    = {2024},
  doi     = {10.1016/j.ajhg.2023.12.006},
  pmid    = {38181731},
  url     = {https://doi.org/10.1016/j.ajhg.2023.12.006}
}

@article{panza2016-27429978,
  author  = {Panza, F. and Solfrizzi, V. and Seripa, D. and Imbimbo, B. P. and Lozupone, M. and Santamato, A. and Zecca, C. and Barulli, M. R. and others},
  title   = {{Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease}},
  journal = {BioMed research international},
  year    = {2016},
  doi     = {10.1155/2016/3245935},
  pmid    = {27429978},
  url     = {https://doi.org/10.1155/2016/3245935}
}

@article{larson1987-2886086,
  author  = {Larson, E. B. and Kukull, W. A. and Buchner, D. and Reifler, B. V.},
  title   = {{Adverse drug reactions associated with global cognitive impairment in elderly persons}},
  journal = {Annals of internal medicine},
  year    = {1987},
  doi     = {10.7326/0003-4819-107-2-169},
  pmid    = {2886086},
  url     = {https://doi.org/10.7326/0003-4819-107-2-169}
}

@article{schultz2018-29507718,
  author  = {Schultz, B. G. and Patten, D. K. and Berlau, D. J.},
  title   = {{The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms}},
  journal = {Translational neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s40035-018-0110-3},
  pmid    = {29507718},
  url     = {https://doi.org/10.1186/s40035-018-0110-3}
}

@article{belmontrausch2026-42265098,
  author  = {Belmont-Rausch, Dylan M and Ludwig, Mette Q and Bentsen, Marie A and Hansen, Stine N and Secher, Anna and Holst, Dorte and Moreno, Jaime and Das, Vivek and others},
  title   = {{Semaglutide attenuates neuroinflammation in male mice}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-74038-4},
  pmid    = {42265098},
  url     = {https://doi.org/10.1038/s41467-026-74038-4}
}

@article{khan2025-41388533,
  author  = {Khan, Ali R and Makhoul, Gennifer Wahbah and Raji, Mukaila A},
  title   = {{Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults}},
  journal = {Endocrine regulations},
  year    = {2025},
  doi     = {10.2478/enr-2025-0030},
  pmid    = {41388533},
  url     = {https://doi.org/10.2478/enr-2025-0030}
}

@article{cerimagic2025-41564203,
  author  = {Čerimagić, Denis},
  title   = {{Pseudo-dementia caused by metformin-induced vitamin B12 deficiency}},
  journal = {Psychiatria Danubina},
  year    = {2025},
  doi     = {10.24869/psyd.2025.370},
  pmid    = {41564203},
  url     = {https://doi.org/10.24869/psyd.2025.370}
}

@article{taylor2024-38175261,
  author  = {Taylor, L. W. and Simzer, E. M. and Pimblett, C. and Lacey-Solymar, O. T. T. and McGeachan, R. I. and Meftah, S. and Rose, J. L. and Spires-Jones, M. P. and others},
  title   = {{p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003}},
  journal = {Acta neuropathologica},
  year    = {2024},
  doi     = {10.1007/s00401-023-02667-w},
  pmid    = {38175261},
  url     = {https://doi.org/10.1007/s00401-023-02667-w}
}

@article{wisse2025-39985478,
  author  = {Wisse, L. E. M. and Wuestefeld, A. and Murray, M. E. and Jagust, W. and La Joie, R.},
  title   = {{Role of tau versus TDP-43 pathology on medial temporal lobe atrophy in aging and Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.14582},
  pmid    = {39985478},
  url     = {https://doi.org/10.1002/alz.14582}
}

@article{pini2025-39741782,
  author  = {Pini, L. and Lista, S. and Griffa, A. and Allali, G. and Imbimbo, B. P.},
  title   = {{Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?}},
  journal = {Brain communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcae460},
  pmid    = {39741782},
  url     = {https://doi.org/10.1093/braincomms/fcae460}
}

@article{hung2024-37882537,
  author  = {Hung, C. and Patani, R.},
  title   = {{Elevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia}},
  journal = {Brain : a journal of neurology},
  year    = {2024},
  doi     = {10.1093/brain/awad370},
  pmid    = {37882537},
  url     = {https://doi.org/10.1093/brain/awad370}
}

@article{lindboe1998-9707335,
  author  = {Lindboe, C. F. and Hansen, H. B.},
  title   = {{The frequency of Lewy bodies in a consecutive autopsy series}},
  journal = {Clinical neuropathology},
  year    = {1998},
  pmid    = {9707335}
}

@article{vermeiren2024-39583643,
  author  = {Vermeiren, M. R. and Calandri, I. L. and van der Flier, W. M. and van de Giessen, E. and Ossenkoppele, R.},
  title   = {{Survey among experts on the future role of tau-PET in clinical practice and trials}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2024},
  doi     = {10.1002/dad2.70033},
  pmid    = {39583643},
  url     = {https://doi.org/10.1002/dad2.70033}
}

@article{chen2025-40339155,
  author  = {Chen, X. Q. and Zuo, X. and Becker, A. and Mante, M. and Florio, J. B. and Jadhav, S. G. and Albay, R. and Johnstone, A. and others},
  title   = {{Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70022},
  pmid    = {40339155},
  url     = {https://doi.org/10.1002/alz.70022}
}

@article{karim2025-40619690,
  author  = {Karim, F. and Delaney, B. A. and Mondal, R. and Liang, C. and Serrano, G. E. and Beach, T. G. and Mukherjee, J.},
  title   = {{[125I]IPPI for Tau Imaging: Binding Studies in Postmortem Human Alzheimer's Disease Hippocampus-Subiculum and Evaluation of Drug Effects}},
  journal = {Synapse (New York, N.Y.)},
  year    = {2025},
  doi     = {10.1002/syn.70024},
  pmid    = {40619690},
  url     = {https://doi.org/10.1002/syn.70024}
}

@article{ahammad2025-40556661,
  author  = {Ahammad, R. U. and Spencer, B. and Quach, B. and Salehi, S. and Rissman, R. A.},
  title   = {{A splice-switching antisense oligonucleotide targeting APP reduces accumulation of α-synuclein in a mouse model of Parkinson's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2025},
  doi     = {10.1002/trc2.70117},
  pmid    = {40556661},
  url     = {https://doi.org/10.1002/trc2.70117}
}

@article{wang2024-39445596,
  author  = {Wang, W. and Wang, Q. and Qi, X. and Gurney, M. and Perry, G. and Volkow, N. D. and Davis, P. B. and Kaelber, D. C. and others},
  title   = {{Associations of semaglutide with first-time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14313},
  pmid    = {39445596},
  url     = {https://doi.org/10.1002/alz.14313}
}

@article{vitek2023-36749830,
  author  = {Vitek, G. E. and Decourt, B. and Sabbagh, M. N.},
  title   = {{Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease}},
  journal = {Expert opinion on investigational drugs},
  year    = {2023},
  doi     = {10.1080/13543784.2023.2178414},
  pmid    = {36749830},
  url     = {https://doi.org/10.1080/13543784.2023.2178414}
}

@article{holscher2024-38677445,
  author  = {Hölscher, C.},
  title   = {{Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?}},
  journal = {Neuropharmacology},
  year    = {2024},
  doi     = {10.1016/j.neuropharm.2024.109952},
  pmid    = {38677445},
  url     = {https://doi.org/10.1016/j.neuropharm.2024.109952}
}

@article{lee2025-01baa622,
  author  = {Lee, Wen-Teng},
  title   = {{GLP-1 Receptor Agonists Reduce Dementia and Alzheimer Disease Risk in Patients with Diabetes and Advanced CKD: Real-World Evidence from TriNetX}},
  journal = {Journal of the American Society of Nephrology},
  year    = {2025},
  doi     = {10.1681/asn.2025rdy8v05v},
  url     = {https://doi.org/10.1681/asn.2025rdy8v05v}
}

@article{xu2021-32366951,
  author  = {Xu, Y. and Du, S. and Marsh, J. A. and Horie, K. and Sato, C. and Ballabio, A. and Karch, C. M. and Holtzman, D. M. and others},
  title   = {{TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading}},
  journal = {Molecular psychiatry},
  year    = {2021},
  doi     = {10.1038/s41380-020-0738-0},
  pmid    = {32366951},
  url     = {https://doi.org/10.1038/s41380-020-0738-0}
}

@article{west2017-29181488,
  author  = {West, T. and Hu, Y. and Verghese, P. B. and Bateman, R. J. and Braunstein, J. B. and Fogelman, I. and Budur, K. and Florian, H. and others},
  title   = {{Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2017},
  doi     = {10.14283/jpad.2017.36},
  pmid    = {29181488},
  url     = {https://doi.org/10.14283/jpad.2017.36}
}

@article{tolnay1997-9144586,
  author  = {Tolnay, M. and Spillantini, M. G. and Goedert, M. and Ulrich, J. and Langui, D. and Probst, A.},
  title   = {{Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons}},
  journal = {Acta neuropathologica},
  year    = {1997},
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@article{yun2018-29892066,
  author  = {Yun, S. P. and Kam, T. I. and Panicker, N. and Kim, S. and Oh, Y. and Park, J. S. and Kwon, S. H. and others},
  title   = {{Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease}},
  journal = {Nature medicine},
  year    = {2018},
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  pmid    = {29892066},
  url     = {https://doi.org/10.1038/s41591-018-0051-5}
}

@article{avilesolmos2013-22344583,
  author  = {Aviles-Olmos, I. and Limousin, P. and Lees, A. and Foltynie, T.},
  title   = {{Parkinson's disease, insulin resistance and novel agents of neuroprotection}},
  journal = {Brain : a journal of neurology},
  year    = {2013},
  doi     = {10.1093/brain/aws009},
  pmid    = {22344583},
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@article{nowell2023-36258018,
  author  = {Nowell, J. and Blunt, E. and Edison, P.},
  title   = {{Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease}},
  journal = {Molecular psychiatry},
  year    = {2023},
  doi     = {10.1038/s41380-022-01792-4},
  pmid    = {36258018},
  url     = {https://doi.org/10.1038/s41380-022-01792-4}
}

@article{komulainen2008-18707012,
  author  = {Komulainen, P. and Pedersen, M. and Hänninen, T. and Bruunsgaard, H. and Lakka, T. A. and Kivipelto, M. and Hassinen, M. and Rauramaa, T. H. and others},
  title   = {{BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study}},
  journal = {Neurobiology of learning and memory},
  year    = {2008},
  doi     = {10.1016/j.nlm.2008.07.014},
  pmid    = {18707012},
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@article{rodriguez2021-33589615,
  author  = {Rodriguez, S. and Hug, C. and Todorov, P. and Moret, N. and Boswell, S. A. and Evans, K. and Zhou, G. and Johnson, N. T. and others},
  title   = {{Machine learning identifies candidates for drug repurposing in Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-21330-0},
  pmid    = {33589615},
  url     = {https://doi.org/10.1038/s41467-021-21330-0}
}

@article{gejl2012-22929437,
  author  = {Gejl, Michael and Egefjord, Lærke and Lerche, Susanne Søgaard and Vang, Kim and Bibby, Bo Martin and Holst, Jens Juul and Mengel, Annette and Møller, Niels and others},
  title   = {{Glucagon-Like Peptide-1 Decreases Intracerebral Glucose Content by Activating Hexokinase and Changing Glucose Clearance during Hyperglycemia}},
  journal = {Journal of Cerebral Blood Flow \& Metabolism},
  year    = {2012},
  doi     = {10.1038/jcbfm.2012.118},
  pmid    = {22929437},
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@article{venning2012-23121204,
  author  = {Venning, Vanessa A. and Taghipour, Kathy and Mustapa, M.F. Mohd and Highet, A.S. and Kirtschig, Gudula and Hughes, J.R. and McLelland, J. and McDonagh, Andrew J. G. and others},
  title   = {{British Association of Dermatologists’ guidelines for the management of bullous pemphigoid 2012}},
  journal = {British Journal of Dermatology},
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@article{krishnan2022-35589711,
  author  = {Krishnan, G. and Raitcheva, D. and Bartlett, D. and Prudencio, M. and McKenna-Yasek, D. M. and Douthwright, C. and Oskarsson, B. E. and Ladha, S. and others},
  title   = {{Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD}},
  journal = {Nature communications},
  year    = {2022},
  doi     = {10.1038/s41467-022-30387-4},
  pmid    = {35589711},
  url     = {https://doi.org/10.1038/s41467-022-30387-4}
}

@article{huang2023-37673952,
  author  = {Huang, Y. and Wen, J. and Ramirez, L. M. and Gümüşdil, E. and Pokhrel, P. and Man, V. H. and Ye, H. and Han, Y. and others},
  title   = {{Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-41241-6},
  pmid    = {37673952},
  url     = {https://doi.org/10.1038/s41467-023-41241-6}
}

@article{behrouzi2016-27036121,
  author  = {Behrouzi, R. and Liu, X. and Wu, D. and Robinson, A. C. and Tanaguchi-Watanabe, S. and Rollinson, S. and Shi, J. and Tian, J. and others},
  title   = {{Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy}},
  journal = {Acta neuropathologica communications},
  year    = {2016},
  doi     = {10.1186/s40478-016-0301-z},
  pmid    = {27036121},
  url     = {https://doi.org/10.1186/s40478-016-0301-z}
}

@article{luan2023-37012334,
  author  = {Luan, W. and Wright, A. L. and Brown-Wright, H. and Le, S. and San Gil, R. and Madrid San Martin, L. and Ling, K. and Jafar-Nejad, P. and others},
  title   = {{Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD}},
  journal = {Molecular psychiatry},
  year    = {2023},
  doi     = {10.1038/s41380-023-02036-9},
  pmid    = {37012334},
  url     = {https://doi.org/10.1038/s41380-023-02036-9}
}

@article{broder1990-1698042,
  author  = {Broder, S. and Mitsuya, H. and Yarchoan, R. and Pavlakis, G. N.},
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@article{shiarli2006-16866983,
  author  = {Shiarli, A. M. and Jennings, R. and Shi, J. and Bailey, K. and Davidson, Y. and Tian, J. and Bigio, E. H. and Ghetti, B. and others},
  title   = {{Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease}},
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@article{espay2023-36796939,
  author  = {Espay, A. J. and Herrup, K. and Daly, T.},
  title   = {{Finding the falsification threshold of the toxic proteinopathy hypothesis in neurodegeneration}},
  journal = {Handbook of clinical neurology},
  year    = {2023},
  doi     = {10.1016/b978-0-323-85538-9.00008-0},
  pmid    = {36796939},
  url     = {https://doi.org/10.1016/b978-0-323-85538-9.00008-0}
}

@article{wang2023-36598274,
  author  = {Wang, E. W. and Brown, G. L. and Lewis, M. M. and Jellen, L. C. and Pu, C. and Johnson, M. L. and Chen, H. and Kong, L. and others},
  title   = {{Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2023},
  doi     = {10.1002/mds.29311},
  pmid    = {36598274},
  url     = {https://doi.org/10.1002/mds.29311}
}

@article{wan2023-36710682,
  author  = {Wan, K. and Yin, W. and Tang, Y. and Zhu, W. and Wang, Z. and Zhou, X. and Zhang, W. and Zhang, C. and others},
  title   = {{Brain Gray Matter Volume Mediated the Correlation Between Plasma P-Tau and Cognitive Function of Early Alzheimer's Disease in China: A Cross-Sectional Observational Study}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2023},
  doi     = {10.3233/jad-221100},
  pmid    = {36710682},
  url     = {https://doi.org/10.3233/jad-221100}
}

@article{liu2021-34535787,
  author  = {Liu, K. Y. and Howard, R.},
  title   = {{Can we learn lessons from the FDA's approval of aducanumab?}},
  journal = {Nature reviews. Neurology},
  year    = {2021},
  doi     = {10.1038/s41582-021-00557-x},
  pmid    = {34535787},
  url     = {https://doi.org/10.1038/s41582-021-00557-x}
}

@article{leinenga2021-33836798,
  author  = {Leinenga, G. and Koh, W. K. and Götz, J.},
  title   = {{A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00809-4},
  pmid    = {33836798},
  url     = {https://doi.org/10.1186/s13195-021-00809-4}
}

@article{morato2022-36012569,
  author  = {Morató, X. and Pytel, V. and Jofresa, S. and Ruiz, A. and Boada, M.},
  title   = {{Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimer's Disease: Towards a Personalized Polypharmacology Patient-Centered Approach}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23169305},
  pmid    = {36012569},
  url     = {https://doi.org/10.3390/ijms23169305}
}

@article{lee2026-41697144,
  author  = {Lee, Wen-Teng and Jing Tong, W. A. N. G. and Tsai, Ming‐Hsien and Fang, Yu‐Wei},
  title   = {{GLP-1 receptor agonists reduce dementia and Alzheimer disease risk in diabetic patients with CKD}},
  journal = {Nephrology Dialysis Transplantation},
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  title   = {{Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes}},
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@article{xu2021-34291435,
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  title   = {{Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model}},
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@article{courade2025-41448139,
  author  = {Courade, Jean-Philippe and Zetterberg, Henrik and Höglinger, Günter U and Dewachter, Ilse},
  title   = {{The evolving landscape of Alzheimer's disease therapy: From Aβ to tau}},
  journal = {Cell},
  year    = {2025},
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  pmid    = {41448139},
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}

@article{llibreguerra2025-41184455,
  author  = {Llibre-Guerra, Jorge J and McDade, Eric M and Schindler, Suzanne E and Clifford, David B and Supnet, Charlene and Atri, Alireza and Bateman, Randall J},
  title   = {{Towards pharmacological prevention of Alzheimer disease}},
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  year    = {2025},
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@article{bravo2024-38915105,
  author  = {Bravo, Celeste Parra and Krukowski, Karen and Barker, Sarah and Wang, Chao and Li, Yaqiao and Fan, Li and Vázquez-Rosa, Edwin and Shin, Min-Kyoo and others},
  title   = {{Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-024-00733-9},
  pmid    = {38915105},
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}

@article{gaikwad2024-38959324,
  author  = {Gaikwad, Sagar and Puangmalai, Nicha and Sonawane, Minal and Montalbano, Mauro and Price, Rachel and Iyer, Malini S and Ray, Anamika and Moreno, Sandra and others},
  title   = {{Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adj5958},
  pmid    = {38959324},
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}

@article{olluri2025-39908690,
  author  = {Olluri, Andi},
  title   = {{Clinical trials targeting tau should be halted}},
  journal = {Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year    = {2025},
  doi     = {10.1016/j.jocn.2025.111101},
  pmid    = {39908690},
  url     = {https://doi.org/10.1016/j.jocn.2025.111101}
}

@article{weber2024-38763001,
  author  = {Weber, Patrick and Bojarová, Pavla and Brouzdová, Jitka and Křen, Vladimír and Kulik, Natalia and Stütz, Arnold E and Thonhofer, Martin and Wrodnigg, Tanja M},
  title   = {{Diaminocyclopentane - l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase}},
  journal = {Bioorganic chemistry},
  year    = {2024},
  doi     = {10.1016/j.bioorg.2024.107452},
  pmid    = {38763001},
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}

@article{jang2024-39500576,
  author  = {Jang, Elliot and Hoxha, Kevt'her and Mozier, Damian and Insana, Abigail and Farber, Ethan and Changolkar, Lakshmi and Zhang, Bin and Chio, Tak-Ian and others},
  title   = {{Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2024},
  doi     = {10.1523/jneurosci.0877-24.2024},
  pmid    = {39500576},
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}

@article{thangwaritorn2024-38756263,
  author  = {Thangwaritorn, Skylynn and Lee, Christopher and Metchikoff, Elena and Razdan, Vidushi and Ghafary, Suliman and Rivera, Dominic and Pinto, Alvaro and Pemminati, Sudhakar},
  title   = {{A Review of Recent Advances in the Management of Alzheimer's Disease}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.58416},
  pmid    = {38756263},
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}

@article{horsley2024-38512662,
  author  = {Horsley, David and Rickard, Janet E and Vorley, Thomas and Leeper, Matilda F and Wischik, Claude M and Harrington, Charles R},
  title   = {{Assays for the Screening and Characterization of Tau Aggregation Inhibitors}},
  journal = {Methods in molecular biology (Clifton, N.J.)},
  year    = {2024},
  doi     = {10.1007/978-1-0716-3629-9_5},
  pmid    = {38512662},
  url     = {https://doi.org/10.1007/978-1-0716-3629-9_5}
}

@article{delgiudice2024-38508903,
  author  = {Del Giudice, Kirsys Patricia and Cosgaya, Marina and Zaro, Idoia and Ravasi, Valeria and Santacruz, Pilar and Painous, Celia and Fernández, Manel and Cámara, Ana and others},
  title   = {{Anti-alpha synuclein and anti-tau immunotherapies: Can a cocktail approach work?}},
  journal = {Parkinsonism \& related disorders},
  year    = {2024},
  doi     = {10.1016/j.parkreldis.2024.106080},
  pmid    = {38508903},
  url     = {https://doi.org/10.1016/j.parkreldis.2024.106080}
}

@article{zhang2025-41017406,
  author  = {Zhang, Han and Pan, Ming-Tian and Li, Yu-Xuan and Li, Xiao-Jiang and Guo, Xiang-Yu and He, Da-Jian},
  title   = {{Understanding Tau pathology: Insights from animal models}},
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  pmid    = {41017406},
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}

@article{rosenqvist2018-30386817,
  author  = {Rosenqvist, Nina and Asuni, Ayodeji A and Andersson, Christian R and Christensen, Søren and Daechsel, Justus A and Egebjerg, Jan and Falsig, Jeppe and Helboe, Lone and others},
  title   = {{Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2018},
  doi     = {10.1016/j.trci.2018.09.005},
  pmid    = {30386817},
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}

@article{schuster2024-38429929,
  author  = {Schuster, Kristen H and Zalon, Annie J and DiFranco, Danielle M and Putka, Alexandra F and Stec, Nicholas R and Jarrah, Sabrina I and Naeem, Arsal and Haque, Zaid and others},
  title   = {{ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice}},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year    = {2024},
  doi     = {10.1016/j.ymthe.2024.02.033},
  pmid    = {38429929},
  url     = {https://doi.org/10.1016/j.ymthe.2024.02.033}
}

@article{smith2024-38618323,
  author  = {Smith, Blake and Ownby, Raymond L},
  title   = {{Disease-Modifying Treatments and Their Future in Alzheimer's Disease Management}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.56105},
  pmid    = {38618323},
  url     = {https://doi.org/10.7759/cureus.56105}
}

@article{zhou2024-39613463,
  author  = {Zhou, Futao and Zhao, Yushi and Sun, Yangyan and Chen, Wanjiao},
  title   = {{Molecular Insights into Tau Pathology and its Therapeutic Strategies in Alzheimer's Disease}},
  journal = {Journal of integrative neuroscience},
  year    = {2024},
  doi     = {10.31083/j.jin2311197},
  pmid    = {39613463},
  url     = {https://doi.org/10.31083/j.jin2311197}
}

@article{shi2024-38255905,
  author  = {Shi, Huahua and Zhao, Yan},
  title   = {{Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25020831},
  pmid    = {38255905},
  url     = {https://doi.org/10.3390/ijms25020831}
}

@article{vejandla2024-38313929,
  author  = {Vejandla, Bhuvanasai and Savani, Sarah and Appalaneni, Rohith and Veeravalli, Rithik S and Gude, Sai Sravya},
  title   = {{Alzheimer's Disease: The Past, Present, and Future of a Globally Progressive Disease}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.51705},
  pmid    = {38313929},
  url     = {https://doi.org/10.7759/cureus.51705}
}

@article{pawar2025-40395755,
  author  = {Pawar, Shreya and Rauf, Mohd Ahmar and Abdelhady, Hosam and Iyer, Arun K},
  title   = {{Tau-targeting nanoparticles for treatment of Alzheimer's disease}},
  journal = {Exploration (Beijing, China)},
  year    = {2025},
  doi     = {10.1002/exp.20230137},
  pmid    = {40395755},
  url     = {https://doi.org/10.1002/exp.20230137}
}

@article{godugu2025-41562774,
  author  = {Godugu, Deepika and Gattu, Kranthi and Suri, Parul and Daartey, Abel B and Jadhav, Krishna and Rojekar, Satish},
  title   = {{Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches}},
  journal = {Antibodies (Basel, Switzerland)},
  year    = {2025},
  doi     = {10.3390/antib15010001},
  pmid    = {41562774},
  url     = {https://doi.org/10.3390/antib15010001}
}

@article{bang2024-39634029,
  author  = {Bang, Sookhee and Song, Jeong Kuen and Lee, Kwan Hee},
  title   = {{Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer's diseases}},
  journal = {IBRO neuroscience reports},
  year    = {2024},
  doi     = {10.1016/j.ibneur.2024.11.005},
  pmid    = {39634029},
  url     = {https://doi.org/10.1016/j.ibneur.2024.11.005}
}

@article{tanabe2025-40276591,
  author  = {Tanabe, Hirokazu and Maeda, Sumihiro and Sano, Etsuko and Sakai, Norio and Endoh-Yamagami, Setsu and Okano, Hideyuki},
  title   = {{Tau aggregation induces cell death in iPSC-derived neurons}},
  journal = {Aging brain},
  year    = {2025},
  doi     = {10.1016/j.nbas.2025.100136},
  pmid    = {40276591},
  url     = {https://doi.org/10.1016/j.nbas.2025.100136}
}

@article{sabbagh2025-40782673,
  author  = {Sabbagh, Marwan Noel and Kennedy, Jessica and Majeed, Jad and Decourt, Boris},
  title   = {{Alzheimer's disease: Clinical trials to watch}},
  journal = {Med (New York, N.Y.)},
  year    = {2025},
  doi     = {10.1016/j.medj.2025.100771},
  pmid    = {40782673},
  url     = {https://doi.org/10.1016/j.medj.2025.100771}
}

@article{alshehri2025-40498212,
  author  = {Alshehri, Ghadah H and Al-Kuraishy, Hayder M and Waheed, Huda Jaber and Al-Gareeb, Ali I and Faheem, Safaa A and Alexiou, Athanasios and Papadakis, Marios and Batiha, Gaber El-Saber},
  title   = {{Tirzepatide: a novel therapeutic approach for Alzheimer's disease}},
  journal = {Metabolic brain disease},
  year    = {2025},
  doi     = {10.1007/s11011-025-01649-z},
  pmid    = {40498212},
  url     = {https://doi.org/10.1007/s11011-025-01649-z}
}

@article{zhou2025-40344943,
  author  = {Zhou, Zhi Dong and Yi, Lingxiao and Popławska-Domaszewicz, Karolina and Chaudhuri, Kallol Ray and Jankovic, Joseph and Tan, Eng King},
  title   = {{Glucagon-like peptide-1 receptor agonists in neurodegenerative diseases: Promises and challenges}},
  journal = {Pharmacological research},
  year    = {2025},
  doi     = {10.1016/j.phrs.2025.107770},
  pmid    = {40344943},
  url     = {https://doi.org/10.1016/j.phrs.2025.107770}
}

@article{himmerich2025-40042613,
  author  = {Himmerich, Hubertus},
  title   = {{[Glucagon-like peptide-1 receptor agonists: a new pharmacological treatment option for psychiatric illnesses?]}},
  journal = {Der Nervenarzt},
  year    = {2025},
  doi     = {10.1007/s00115-025-01813-x},
  pmid    = {40042613},
  url     = {https://doi.org/10.1007/s00115-025-01813-x}
}

@article{zarei2025-40620322,
  author  = {Zarei, Malek and Sabetkasaei, Masoumeh and Mozafari, Masoud and Zaeri, Sasan},
  title   = {{The expanding role of semaglutide: beyond glycemic control}},
  journal = {Journal of diabetes and metabolic disorders},
  year    = {2025},
  doi     = {10.1007/s40200-025-01663-z},
  pmid    = {40620322},
  url     = {https://doi.org/10.1007/s40200-025-01663-z}
}

@article{moaket2025-41226780,
  author  = {Moaket, Osama Sobhi and Obaid, Sarah Eyad and Obaid, Fawaz Eyad and Shakeeb, Yusuf Abdulkarim and Elsharief, Samir Mohammed and Tania, Afrin and Darwish, Radwan and Butler, Alexandra E and others},
  title   = {{GLP-1 and the Degenerating Brain: Exploring Mechanistic Insights and Therapeutic Potential}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms262110743},
  pmid    = {41226780},
  url     = {https://doi.org/10.3390/ijms262110743}
}

@article{west2025-40172827,
  author  = {West, Juliana and Li, Maggie and Wong, Sabrina and Le, Gia Han and Teopiz, Kayla M and Valentino, Kyle and Dri, Christine E and McIntyre, Roger S},
  title   = {{Are Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Central Nervous System (CNS) Penetrant: A Narrative Review}},
  journal = {Neurology and therapy},
  year    = {2025},
  doi     = {10.1007/s40120-025-00724-y},
  pmid    = {40172827},
  url     = {https://doi.org/10.1007/s40120-025-00724-y}
}

@article{pillarisetti2025-39902055,
  author  = {Pillarisetti, Lekha and Agrawal, Devendra K},
  title   = {{Semaglutide: Double-edged Sword with Risks and Benefits}},
  journal = {Archives of internal medicine research},
  year    = {2025},
  doi     = {10.26502/aimr.0189},
  pmid    = {39902055},
  url     = {https://doi.org/10.26502/aimr.0189}
}

@article{zhang2024-39405916,
  author  = {Zhang, Yinbing and Tang, Cheng and He, Yao and Zhang, Yingqian and Li, Qinxi and Zhang, Ting and Zhao, Bangcheng and Tong, Aiping and others},
  title   = {{Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and human brain organoid models}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2024},
  doi     = {10.1016/j.biopha.2024.117540},
  pmid    = {39405916},
  url     = {https://doi.org/10.1016/j.biopha.2024.117540}
}

@article{roy2025-40738791,
  author  = {Roy, Akash and Dawson, Valina L and Dawson, Ted M},
  title   = {{From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2025},
  doi     = {10.1016/j.neurot.2025.e00712},
  pmid    = {40738791},
  url     = {https://doi.org/10.1016/j.neurot.2025.e00712}
}

@article{germano2024-39216535,
  author  = {Germano, Leticia Forny and Koehler, Jacqueline A and Baggio, Laurie L and Cui, Fiona and Wong, Chi Kin and Rittig, Nikolaj and Cao, Xiemin and Matthews, Dianne and others},
  title   = {{The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice}},
  journal = {Molecular metabolism},
  year    = {2024},
  doi     = {10.1016/j.molmet.2024.102019},
  pmid    = {39216535},
  url     = {https://doi.org/10.1016/j.molmet.2024.102019}
}

@article{holscher2025-40938528,
  author  = {Hölscher, Christian},
  title   = {{Incretin Hormones GLP-1 and GIP Normalize Energy Utilization and Reduce Inflammation in the Brain in Alzheimer's Disease and Parkinson's Disease: From Repurposed GLP-1 Receptor Agonists to Novel Dual GLP-1/GIP Receptor Agonists as Potential Disease-Modifying Therapies}},
  journal = {CNS drugs},
  year    = {2025},
  doi     = {10.1007/s40263-025-01226-z},
  pmid    = {40938528},
  url     = {https://doi.org/10.1007/s40263-025-01226-z}
}

@article{zhang2025-40882702,
  author  = {Zhang, Meng-Wei and Zhou, Wan-Yi and Li, Xin-Yi and Xu, Zhi-Heng and Lin, Hua-Mei and Tang, Yi-Lin and Zhao, Jue and Chen, Chen and others},
  title   = {{GLP-1 receptor agonist semaglutide ameliorates motor deficits and tau pathology in the rTg4510s mouse model}},
  journal = {Neuropharmacology},
  year    = {2025},
  doi     = {10.1016/j.neuropharm.2025.110659},
  pmid    = {40882702},
  url     = {https://doi.org/10.1016/j.neuropharm.2025.110659}
}

@article{sawamura2025-40001315,
  author  = {Sawamura, Toshitaka and Karashima, Shigehiro and Ohmori, Ai and Kometani, Mitsuhiro and Yoneda, Takashi},
  title   = {{Impacts of tirzepatide on older patients with diminished β-cell function and dementia}},
  journal = {Geriatrics \& gerontology international},
  year    = {2025},
  doi     = {10.1111/ggi.70018},
  pmid    = {40001315},
  url     = {https://doi.org/10.1111/ggi.70018}
}

@article{schnell2024-38504284,
  author  = {Schnell, Oliver and Barnard-Kelly, Katharine and Battelino, Tadej and Ceriello, Antonio and Larsson, Helena Elding and Fernández-Fernández, Beatriz and Forst, Thomas and Frias, Juan-Pablo and others},
  title   = {{CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes}},
  journal = {Cardiovascular diabetology},
  year    = {2024},
  doi     = {10.1186/s12933-024-02180-8},
  pmid    = {38504284},
  url     = {https://doi.org/10.1186/s12933-024-02180-8}
}

@article{ibrahim2025-40964464,
  author  = {Ibrahim, Ruba and Kambal, Aya and Abdelmajeed, Mohammed A},
  title   = {{Glucagon-Like Peptide-1 Receptor Agonists in Neurodegenerative Diseases: A Comprehensive Review}},
  journal = {Cureus},
  year    = {2025},
  doi     = {10.7759/cureus.92441},
  pmid    = {40964464},
  url     = {https://doi.org/10.7759/cureus.92441}
}

@article{akita2024-38185192,
  author  = {Akita, Tomomi and Shimamura, Mizuki and Tezuka, Ayano and Takagi, Marina and Yamashita, Chikamasa},
  title   = {{GLP-1 derivatives with functional sequences transit and migrate through trigeminal neurons}},
  journal = {European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year    = {2024},
  doi     = {10.1016/j.ejpb.2024.114176},
  pmid    = {38185192},
  url     = {https://doi.org/10.1016/j.ejpb.2024.114176}
}

@article{abdulrazeq2024-39959894,
  author  = {Abdulrazeq, Hael and Taman, Mazen and Ali, Rohaid and Doberstein, Cody and Sullivan, Patricia and Sampath, Prakash and Telfeian, Albert and Gokaslan, Ziya and others},
  title   = {{GLP-1 Receptor Agonists: Beyond Diabetes-What the Neurosurgeon Needs to Know}},
  journal = {Neurosurgery practice},
  year    = {2024},
  doi     = {10.1227/neuprac.0000000000000098},
  pmid    = {39959894},
  url     = {https://doi.org/10.1227/neuprac.0000000000000098}
}

@article{barrett2024-38915346,
  author  = {Barrett, Emma and Ivey, Gabrielle and Cunningham, Adam and Coffman, Gary and Pemberton, Tyera and Lee, Chan and Patra, Prabir and Day, James B and others},
  title   = {{Reduced GLP-1R availability in the caudate nucleus with Alzheimer's disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2024},
  doi     = {10.3389/fnagi.2024.1350239},
  pmid    = {38915346},
  url     = {https://doi.org/10.3389/fnagi.2024.1350239}
}

@article{crook2024-39422964,
  author  = {Crook, Harry and Edison, Paul},
  title   = {{Incretin Mimetics as Potential Disease Modifying Treatment for Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-240730},
  pmid    = {39422964},
  url     = {https://doi.org/10.3233/jad-240730}
}

@article{kopp2024-39062586,
  author  = {Kopp, Katherine O and Li, Yazhou and Glotfelty, Elliot J and Tweedie, David and Greig, Nigel H},
  title   = {{Incretin-Based Multi-Agonist Peptides Are Neuroprotective and Anti-Inflammatory in Cellular Models of Neurodegeneration}},
  journal = {Biomolecules},
  year    = {2024},
  doi     = {10.3390/biom14070872},
  pmid    = {39062586},
  url     = {https://doi.org/10.3390/biom14070872}
}

@article{sasaki2024-39577079,
  author  = {Sasaki, Kana and Fujita, Hiroki and Sato, Takehiro and Kato, Shunske and Takahashi, Yuya and Takeshita, Yukio and Kanda, Takashi and Saito, Takashi and others},
  title   = {{GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2024},
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@article{sundararaman2025-40142784,
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@article{stefano2025-41047006,
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@article{office2025-40429612,
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@article{rybakowski2024-39510063,
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@article{feng2024-38229533,
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@article{ramos2024-38674150,
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@article{xie2024-39096284,
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@article{cho2024-38238285,
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@article{barkerhaliski2025-39784685,
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@article{jain2024-38160285,
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@article{conceicao2024-39525305,
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@article{panza2023-37620094,
  author  = {Panza, Francesco and Solfrizzi, Vincenzo and Daniele, Antonio and Lozupone, Madia},
  title   = {{Passive tau-based immunotherapy for tauopathies}},
  journal = {Handbook of clinical neurology},
  year    = {2023},
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  pmid    = {37620094},
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@article{luciani2023-37122097,
  author  = {Luciani, Marco and Montalbano, Mauro and Troncone, Luca and Bacchin, Camilla and Uchida, Keita and Daniele, Gianlorenzo and Wolf, Bethany Jacobs and Butler, Helen M and others},
  title   = {{Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy}},
  journal = {European heart journal},
  year    = {2023},
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  pmid    = {37122097},
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@article{weber2023-37666109,
  author  = {Weber, Patrick and Mészáros, Zuzana and Bojarová, Pavla and Ebner, Manuel and Fischer, Roland and Křen, Vladimír and Kulik, Natalia and Müller, Philipp and others},
  title   = {{Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase}},
  journal = {Bioorganic chemistry},
  year    = {2023},
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  pmid    = {37666109},
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}

@article{zhu2021-33999598,
  author  = {Zhu, Lin and Xu, Linlin and Wu, Xiaohui and Deng, Fei and Ma, Rujiang and Liu, Yang and Huang, Fan and Shi, Linqi},
  title   = {{Tau-Targeted Multifunctional Nanoinhibitor for Alzheimer's Disease}},
  journal = {ACS applied materials \& interfaces},
  year    = {2021},
  doi     = {10.1021/acsami.1c00257},
  pmid    = {33999598},
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}

@article{panza2023-37405389,
  author  = {Panza, Francesco and Dibello, Vittorio and Sardone, Rodolfo and Castellana, Fabio and Zupo, Roberta and Lampignano, Luisa and Bortone, Ilaria and Stallone, Roberta and others},
  title   = {{Clinical development of passive tau-based immunotherapeutics for treating primary and secondary tauopathies}},
  journal = {Expert opinion on investigational drugs},
  year    = {2023},
  doi     = {10.1080/13543784.2023.2233892},
  pmid    = {37405389},
  url     = {https://doi.org/10.1080/13543784.2023.2233892}
}

@article{self2022-35653415,
  author  = {Self, Wade and Awwad, Khader and Savaryn, John Paul and Schulz, Michael},
  title   = {{An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS}},
  journal = {PloS one},
  year    = {2022},
  doi     = {10.1371/journal.pone.0269157},
  pmid    = {35653415},
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}

@article{koh2021-34884940,
  author  = {Koh, Han Seok and Lee, SangJoon and Lee, Hyo Jin and Min, Jae-Woong and Iwatsubo, Takeshi and Teunissen, Charlotte E and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222313136},
  pmid    = {34884940},
  url     = {https://doi.org/10.3390/ijms222313136}
}

@article{martins2023-38074413,
  author  = {Martins, Dina Rodrigues and Sha, Fern and Van der Elst, Wim and Shih, Pei-Yu and Devoght, Jens and Van Kolen, Kristof and Mercken, Marc and Van Broeck, Bianca and others},
  title   = {{Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies}},
  journal = {Molecular therapy. Methods \& clinical development},
  year    = {2023},
  doi     = {10.1016/j.omtm.2023.101158},
  pmid    = {38074413},
  url     = {https://doi.org/10.1016/j.omtm.2023.101158}
}

@article{oberrauch2021-33524848,
  author  = {Oberrauch, Sara and Metha, Jeremy A and Brian, Maddison L and Barnes, Samuel A and Featherby, Travis J and Lawrence, Andrew J and Hoyer, Daniel and Murawski, Carsten and others},
  title   = {{Reward motivation and cognitive flexibility in tau null-mutation mice}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2020.12.017},
  pmid    = {33524848},
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}

@article{karimi2022-36410182,
  author  = {Karimi, Nastaran and Çatak, Feyza Bayram and Arslan, Ebru and Saghazadeh, Amene and Rezaei, Nima},
  title   = {{Tau immunotherapy in Alzheimer's disease and progressive supranuclear palsy}},
  journal = {International immunopharmacology},
  year    = {2022},
  doi     = {10.1016/j.intimp.2022.109445},
  pmid    = {36410182},
  url     = {https://doi.org/10.1016/j.intimp.2022.109445}
}

@article{gao2023-37418213,
  author  = {Gao, Shudan and Wang, Yun and Ma, Tao and Zhang, Junying},
  title   = {{The Late Stage of Abnormal Aging: Dementia}},
  journal = {Advances in experimental medicine and biology},
  year    = {2023},
  doi     = {10.1007/978-981-99-1627-6_12},
  pmid    = {37418213},
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}

@article{ingham2021-34009955,
  author  = {Ingham, David J and Blankenfeld, Bryce R and Chacko, Shibin and Perera, Chamani and Oakley, Berl R and Gamblin, Truman Christopher},
  title   = {{Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition}},
  journal = {Biochemistry},
  year    = {2021},
  doi     = {10.1021/acs.biochem.1c00111},
  pmid    = {34009955},
  url     = {https://doi.org/10.1021/acs.biochem.1c00111}
}

@article{morello2023-37759477,
  author  = {Morello, Giovanna and Guarnaccia, Maria and La Cognata, Valentina and Latina, Valentina and Calissano, Pietro and Amadoro, Giuseppina and Cavallaro, Sebastiano},
  title   = {{Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment}},
  journal = {Cells},
  year    = {2023},
  doi     = {10.3390/cells12182254},
  pmid    = {37759477},
  url     = {https://doi.org/10.3390/cells12182254}
}

@article{alshamrani2023-37366656,
  author  = {Alshamrani, Meshal},
  title   = {{Recent Trends in Active and Passive Immunotherapies of Alzheimer's Disease}},
  journal = {Antibodies (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/antib12020041},
  pmid    = {37366656},
  url     = {https://doi.org/10.3390/antib12020041}
}

@article{brown2022-36517890,
  author  = {Brown, Jennifer L and Hart, Damyan W and Boyle, Gabriel E and Brown, Taylor G and LaCroix, Michael and Baraibar, Andrés M and Pelzel, Ross and Kim, Minwoo and others},
  title   = {{SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex}},
  journal = {Acta neuropathologica communications},
  year    = {2022},
  doi     = {10.1186/s40478-022-01480-y},
  pmid    = {36517890},
  url     = {https://doi.org/10.1186/s40478-022-01480-y}
}

@article{levy2022-36160048,
  author  = {Levy, Simon A and Zuniga, Gabrielle and Gonzalez, Elias M and Butler, David and Temple, Sally and Frost, Bess},
  title   = {{TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy}},
  journal = {Cell reports methods},
  year    = {2022},
  doi     = {10.1016/j.crmeth.2022.100292},
  pmid    = {36160048},
  url     = {https://doi.org/10.1016/j.crmeth.2022.100292}
}

@article{alipour2022-36087426,
  author  = {Alipour, Masoume and Tebianian, Majid and Tofigh, Nahid and Taheri, Reyhaneh Sadat and Mousavi, Sayed Alireza and Naseri, Asal and Ahmadi, Amin and Munawar, Nayla and others},
  title   = {{Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models}},
  journal = {Neuropeptides},
  year    = {2022},
  doi     = {10.1016/j.npep.2022.102285},
  pmid    = {36087426},
  url     = {https://doi.org/10.1016/j.npep.2022.102285}
}

@article{liu2023-36621732,
  author  = {Liu, Xin and She, Weiyi and Sung, Herman H-Y and Williams, Ian D and Qian, Peiyuan},
  title   = {{Tau-aggregation inhibitors derived from Streptomyces tendae MCCC 1A01534 protect HT22 cells against okadaic acid-induced damage}},
  journal = {International journal of biological macromolecules},
  year    = {2023},
  doi     = {10.1016/j.ijbiomac.2023.123170},
  pmid    = {36621732},
  url     = {https://doi.org/10.1016/j.ijbiomac.2023.123170}
}

@article{vagenknecht2022-35128565,
  author  = {Vagenknecht, Patrick and Luzgin, Artur and Ono, Maiko and Ji, Bin and Higuchi, Makoto and Noain, Daniela and Maschio, Cinzia A and Sobek, Jens and others},
  title   = {{Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2022},
  doi     = {10.1007/s00259-022-05708-w},
  pmid    = {35128565},
  url     = {https://doi.org/10.1007/s00259-022-05708-w}
}

@article{hill2021-34737403,
  author  = {Hill, Emily and Karikari, Thomas K and Lantero-Rodriguez, Juan and Zetterberg, Henrik and Blennow, Kaj and Richardson, Magnus J and Wall, Mark J},
  title   = {{Truncating tau reveals different pathophysiological actions of oligomers in single neurons}},
  journal = {Communications biology},
  year    = {2021},
  doi     = {10.1038/s42003-021-02791-x},
  pmid    = {34737403},
  url     = {https://doi.org/10.1038/s42003-021-02791-x}
}

@article{li2023-36717015,
  author  = {Li, Longfei and Miao, Jin and Jiang, Yanli and Dai, Chun-Ling and Iqbal, Khalid and Liu, Fei and Chu, Dandan},
  title   = {{Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice}},
  journal = {Experimental neurology},
  year    = {2023},
  doi     = {10.1016/j.expneurol.2023.114337},
  pmid    = {36717015},
  url     = {https://doi.org/10.1016/j.expneurol.2023.114337}
}

@article{lee2023-36989942,
  author  = {Lee, Tae Suk and Park, Eun Ji and Choi, Minkyu and Oh, Hyun Seok and An, Yejin and Kim, Taehyung and Kim, Tae Hwan and Shin, Beom Soo and others},
  title   = {{Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies in rats}},
  journal = {Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year    = {2023},
  doi     = {10.1016/j.jchromb.2023.123688},
  pmid    = {36989942},
  url     = {https://doi.org/10.1016/j.jchromb.2023.123688}
}

@article{dizchaves2022-35180937,
  author  = {Diz-Chaves, Yolanda and Herrera-Pérez, Salvador and González-Matías, Lucas C and Mallo, Federico},
  title   = {{Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus}},
  journal = {Vitamins and hormones},
  year    = {2022},
  doi     = {10.1016/bs.vh.2021.12.005},
  pmid    = {35180937},
  url     = {https://doi.org/10.1016/bs.vh.2021.12.005}
}

@article{begic2021-34479819,
  author  = {Begic, Edin and Causevic, Mirsada},
  title   = {{Glucagon-Like Peptide-1 Receptor Agonists and Brain Vascular Function}},
  journal = {Heart, lung \& circulation},
  year    = {2021},
  doi     = {10.1016/j.hlc.2021.07.024},
  pmid    = {34479819},
  url     = {https://doi.org/10.1016/j.hlc.2021.07.024}
}

@article{vargassoria2021-34118986,
  author  = {Vargas-Soria, Maria and Carranza-Naval, Maria Jose and Del Marco, Angel and Garcia-Alloza, Monica},
  title   = {{Role of liraglutide in Alzheimer's disease pathology}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00853-0},
  pmid    = {34118986},
  url     = {https://doi.org/10.1186/s13195-021-00853-0}
}

@article{viljoen2023-36740965,
  author  = {Viljoen, Adie and Bain, Stephen C},
  title   = {{Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond}},
  journal = {Endocrinology and metabolism (Seoul, Korea)},
  year    = {2023},
  doi     = {10.3803/enm.2022.1642},
  pmid    = {36740965},
  url     = {https://doi.org/10.3803/enm.2022.1642}
}

@article{qi2022-35985417,
  author  = {Qi, Liqin and Gao, Ruonan and Chen, Zhou and Lin, Donghai and Liu, Zhiqing and Wang, Linxi and Lin, Lijing and Liu, Xiaoying and others},
  title   = {{Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells}},
  journal = {Neurotoxicology},
  year    = {2022},
  doi     = {10.1016/j.neuro.2022.08.007},
  pmid    = {35985417},
  url     = {https://doi.org/10.1016/j.neuro.2022.08.007}
}

@article{chen2023-36470445,
  author  = {Chen, Shang-Der and Chuang, Yao-Chung and Lin, Tsu-Kung and Yang, Jenq-Lin},
  title   = {{Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases}},
  journal = {European journal of pharmacology},
  year    = {2023},
  doi     = {10.1016/j.ejphar.2022.175439},
  pmid    = {36470445},
  url     = {https://doi.org/10.1016/j.ejphar.2022.175439}
}

@article{cummings2022-35128745,
  author  = {Cummings, Jeffrey and Ortiz, Andrew and Castellino, Janelle and Kinney, Jefferson},
  title   = {{Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease}},
  journal = {The European journal of neuroscience},
  year    = {2022},
  doi     = {10.1111/ejn.15619},
  pmid    = {35128745},
  url     = {https://doi.org/10.1111/ejn.15619}
}

@article{li2021-34552561,
  author  = {Li, Qiu-Xuan and Gao, Han and Guo, Yue-Xin and Wang, Bo-Ya and Hua, Rong-Xuan and Gao, Lei and Shang, Hong-Wei and Lu, Xin and others},
  title   = {{GLP-1 and Underlying Beneficial Actions in Alzheimer's Disease, Hypertension, and NASH}},
  journal = {Frontiers in endocrinology},
  year    = {2021},
  doi     = {10.3389/fendo.2021.721198},
  pmid    = {34552561},
  url     = {https://doi.org/10.3389/fendo.2021.721198}
}

@article{deden2021-34942949,
  author  = {Deden, Laura N and Booij, Jan and Grandjean, Joanes and Homberg, Judith R and Hazebroek, Eric J and Gotthardt, Martin and Boss, Marti},
  title   = {{Brain Imaging of the GLP-1 Receptor in Obesity Using 68Ga-NODAGA-Exendin-4 PET}},
  journal = {Brain sciences},
  year    = {2021},
  doi     = {10.3390/brainsci11121647},
  pmid    = {34942949},
  url     = {https://doi.org/10.3390/brainsci11121647}
}

@article{kreiner2023-37191234,
  author  = {Kreiner, Frederik Flindt and von Scholten, Bernt Johan and Kurtzhals, Peter and Gough, Stephen Charles Langford},
  title   = {{Glucagon-like peptide-1 receptor agonists to expand the healthy lifespan: Current and future potentials}},
  journal = {Aging cell},
  year    = {2023},
  doi     = {10.1111/acel.13818},
  pmid    = {37191234},
  url     = {https://doi.org/10.1111/acel.13818}
}

@article{mouhammad2022-35264926,
  author  = {Mouhammad, Zaynab Ahmad and Vohra, Rupali and Horwitz, Anna and Thein, Anna-Sophie and Rovelt, Jens and Cvenkel, Barbara and Williams, Pete A and Azuara-Blanco, Augusto and others},
  title   = {{Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.824054},
  pmid    = {35264926},
  url     = {https://doi.org/10.3389/fnins.2022.824054}
}

@article{liu2021-34676939,
  author  = {Liu, Xiao-Yu and Zhang, Ni and Zhang, Sheng-Xiao and Xu, Ping},
  title   = {{Potential new therapeutic target for Alzheimer's disease: Glucagon-like peptide-1}},
  journal = {The European journal of neuroscience},
  year    = {2021},
  doi     = {10.1111/ejn.15502},
  pmid    = {34676939},
  url     = {https://doi.org/10.1111/ejn.15502}
}

@article{dizchaves2022-36076972,
  author  = {Diz-Chaves, Yolanda and Mastoor, Zainab and Spuch, Carlos and González-Matías, Lucas C and Mallo, Federico},
  title   = {{Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23179583},
  pmid    = {36076972},
  url     = {https://doi.org/10.3390/ijms23179583}
}

@article{lagerupprecht2022-35510183,
  author  = {Lage-Rupprecht, Vanessa and Schultz, Bruce and Dick, Justus and Namysl, Marcin and Zaliani, Andrea and Gebel, Stephan and Pless, Ole and Reinshagen, Jeanette and others},
  title   = {{A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism}},
  journal = {Patterns (New York, N.Y.)},
  year    = {2022},
  doi     = {10.1016/j.patter.2021.100433},
  pmid    = {35510183},
  url     = {https://doi.org/10.1016/j.patter.2021.100433}
}

@article{goodarzi2023-37335453,
  author  = {Goodarzi, Golnaz and Tehrani, Sadra Samavarchi and Fana, Saeed Ebrahimi and Moradi-Sardareh, Hemen and Panahi, Ghodratollah and Maniati, Mahmood and Meshkani, Reza},
  title   = {{Crosstalk between Alzheimer's disease and diabetes: a focus on anti-diabetic drugs}},
  journal = {Metabolic brain disease},
  year    = {2023},
  doi     = {10.1007/s11011-023-01225-3},
  pmid    = {37335453},
  url     = {https://doi.org/10.1007/s11011-023-01225-3}
}

@article{neha2023-36529440,
  author  = {Neha and Parvez, Suhel},
  title   = {{Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer's disease}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2022.101815},
  pmid    = {36529440},
  url     = {https://doi.org/10.1016/j.arr.2022.101815}
}

@article{liu2022-35395400,
  author  = {Liu, Wei and Wang, Gang and Wang, Zhiwen and Wang, Guan and Huang, Jianping and Liu, Bo},
  title   = {{Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases}},
  journal = {Drug discovery today},
  year    = {2022},
  doi     = {10.1016/j.drudis.2022.04.003},
  pmid    = {35395400},
  url     = {https://doi.org/10.1016/j.drudis.2022.04.003}
}

@article{parolo2023-36604493,
  author  = {Parolo, Silvia and Mariotti, Federica and Bora, Pranami and Carboni, Lucia and Domenici, Enrico},
  title   = {{Single-cell-led drug repurposing for Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2023},
  doi     = {10.1038/s41598-023-27420-x},
  pmid    = {36604493},
  url     = {https://doi.org/10.1038/s41598-023-27420-x}
}

@article{feng2021-34163481,
  author  = {Feng, Xiaojun and Chen, Wenxu and Ni, Xiayun and Little, Peter J and Xu, Suowen and Tang, Liqin and Weng, Jianping},
  title   = {{Metformin, Macrophage Dysfunction and Atherosclerosis}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.682853},
  pmid    = {34163481},
  url     = {https://doi.org/10.3389/fimmu.2021.682853}
}

@article{mohle2023-37508364,
  author  = {Möhle, Luisa and Stefan, Katja and Bascuñana, Pablo and Brackhan, Mirjam and Brüning, Thomas and Eiriz, Ivan and El Menuawy, Ahmed and van Genderen, Sylvie and others},
  title   = {{ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer's Disease}},
  journal = {Biology},
  year    = {2023},
  doi     = {10.3390/biology12070932},
  pmid    = {37508364},
  url     = {https://doi.org/10.3390/biology12070932}
}

@article{mansour2021-34139302,
  author  = {Mansour, Heba M and Fawzy, Hala M and El-Khatib, Aiman S and Khattab, Mahmoud M},
  title   = {{Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer's Disease: Current Perspectives and Challenging Prospects}},
  journal = {Neuroscience},
  year    = {2021},
  doi     = {10.1016/j.neuroscience.2021.06.013},
  pmid    = {34139302},
  url     = {https://doi.org/10.1016/j.neuroscience.2021.06.013}
}

@article{khezri2022-35134385,
  author  = {Khezri, Mohammad Rafi and Yousefi, Keyvan and Mahboubi, Negin and Hodaei, Darya and Ghasemnejad-Berenji, Morteza},
  title   = {{Metformin in Alzheimer's disease: An overview of potential mechanisms, preclinical and clinical findings}},
  journal = {Biochemical pharmacology},
  year    = {2022},
  doi     = {10.1016/j.bcp.2022.114945},
  pmid    = {35134385},
  url     = {https://doi.org/10.1016/j.bcp.2022.114945}
}

@article{jimenez2023-36677633,
  author  = {Jiménez, Elvia Mera and Żołek, Teresa and Perez, Paola Gabriela Hernández and Ruvalcaba, Rene Miranda and Nicolás-Vázquez, María Inés and Hernández-Rodríguez, Maricarmen},
  title   = {{Drug Repurposing to Inhibit Histamine N-Methyl Transferase}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/molecules28020576},
  pmid    = {36677633},
  url     = {https://doi.org/10.3390/molecules28020576}
}

@article{nabirotchkin2022-35811522,
  author  = {Nabirotchkin, Serguei and Bouaziz, Jan and Glibert, Fabrice and Mandel, Jonas and Foucquier, Julie and Hajj, Rodolphe and Callizot, Noëlle and Cholet, Nathalie and others},
  title   = {{Combinational Drug Repurposing from Genetic Networks Applied to Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220120},
  pmid    = {35811522},
  url     = {https://doi.org/10.3233/jad-220120}
}

@article{savva2022-35386099,
  author  = {Savva, Kyriaki and Zachariou, Margarita and Bourdakou, Marilena M and Dietis, Nikolas and Spyrou, George M},
  title   = {{Network-based stage-specific drug repurposing for Alzheimer's disease}},
  journal = {Computational and structural biotechnology journal},
  year    = {2022},
  doi     = {10.1016/j.csbj.2022.03.013},
  pmid    = {35386099},
  url     = {https://doi.org/10.1016/j.csbj.2022.03.013}
}

@article{nam2021-34482237,
  author  = {Nam, Geewoo and Suh, Jong-Min and Yi, Yelim and Lim, Mi Hee},
  title   = {{Drug repurposing: small molecules against Cu(II)-amyloid-β and free radicals}},
  journal = {Journal of inorganic biochemistry},
  year    = {2021},
  doi     = {10.1016/j.jinorgbio.2021.111592},
  pmid    = {34482237},
  url     = {https://doi.org/10.1016/j.jinorgbio.2021.111592}
}

@article{urbina2021-34274565,
  author  = {Urbina, Fabio and Puhl, Ana C and Ekins, Sean},
  title   = {{Recent advances in drug repurposing using machine learning}},
  journal = {Current opinion in chemical biology},
  year    = {2021},
  doi     = {10.1016/j.cbpa.2021.06.001},
  pmid    = {34274565},
  url     = {https://doi.org/10.1016/j.cbpa.2021.06.001}
}

@article{zhao2023-36422837,
  author  = {Zhao, Shuai and Fan, Ziqi and Zhang, Xinyi and Li, Zheyu and Shen, Ting and Li, Kaicheng and Yan, Yaping and Yuan, Yunfeng and others},
  title   = {{Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2023},
  doi     = {10.1007/s13311-022-01316-6},
  pmid    = {36422837},
  url     = {https://doi.org/10.1007/s13311-022-01316-6}
}

@article{cai2021-34378011,
  author  = {Cai, Lijun and Lu, Changcheng and Xu, Junlin and Meng, Yajie and Wang, Peng and Fu, Xiangzheng and Zeng, Xiangxiang and Su, Yansen},
  title   = {{Drug repositioning based on the heterogeneous information fusion graph convolutional network}},
  journal = {Briefings in bioinformatics},
  year    = {2021},
  doi     = {10.1093/bib/bbab319},
  pmid    = {34378011},
  url     = {https://doi.org/10.1093/bib/bbab319}
}

@article{pope2021-33899637,
  author  = {Pope, Evans D and Cordes, Laura and Shi, Jiong and Mari, Zoltan and Decourt, Boris and Sabbagh, Marwan Noel},
  title   = {{Dementia with Lewy bodies: emerging drug targets and therapeutics}},
  journal = {Expert opinion on investigational drugs},
  year    = {2021},
  doi     = {10.1080/13543784.2021.1916913},
  pmid    = {33899637},
  url     = {https://doi.org/10.1080/13543784.2021.1916913}
}

@article{hamano2021-34299093,
  author  = {Hamano, Tadanori and Enomoto, Soichi and Shirafuji, Norimichi and Ikawa, Masamichi and Yamamura, Osamu and Yen, Shu-Hui and Nakamoto, Yasunari},
  title   = {{Autophagy and Tau Protein}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22147475},
  pmid    = {34299093},
  url     = {https://doi.org/10.3390/ijms22147475}
}

@article{rybakowski2022-35364656,
  author  = {Rybakowski, Janusz K},
  title   = {{Antiviral, immunomodulatory, and neuroprotective effect of lithium}},
  journal = {Journal of integrative neuroscience},
  year    = {2022},
  doi     = {10.31083/j.jin2102068},
  pmid    = {35364656},
  url     = {https://doi.org/10.31083/j.jin2102068}
}

@article{naseri2023-36474458,
  author  = {Naseri, Amirreza and Sanaie, Sarvin and Hamzehzadeh, Sina and Seyedi-Sahebari, Sepideh and Hosseini, Mohammad-Salar and Gholipour-Khalili, Elnaz and Rezazadeh-Gavgani, Ehsan and Majidazar, Reza and others},
  title   = {{Metformin: new applications for an old drug}},
  journal = {Journal of basic and clinical physiology and pharmacology},
  year    = {2023},
  doi     = {10.1515/jbcpp-2022-0252},
  pmid    = {36474458},
  url     = {https://doi.org/10.1515/jbcpp-2022-0252}
}

@article{byrns2021-33476559,
  author  = {Byrns, China N and Bonini, Nancy M},
  title   = {{An Integrated Multi-omics Approach Identifies Therapeutic Potential for ATP6V1A in Late Onset Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2020.12.015},
  pmid    = {33476559},
  url     = {https://doi.org/10.1016/j.neuron.2020.12.015}
}

@article{zhang2021-34432352,
  author  = {Zhang, Yali and Fan, Xing and Su, Zhangyao and Yuan, Tianli and Yin, Haimeng and Gu, Haohao and Zuo, Yue and Chen, Shiyin and others},
  title   = {{Pretreatment with metformin prevents microcystin-LR-induced tau hyperphosphorylation via mTOR-dependent PP2A and GSK-3β activation}},
  journal = {Environmental toxicology},
  year    = {2021},
  doi     = {10.1002/tox.23354},
  pmid    = {34432352},
  url     = {https://doi.org/10.1002/tox.23354}
}

@article{liao2021-35153733,
  author  = {Liao, Wang and Xu, Jiaxin and Li, Bo and Ruan, Yuting and Li, Tian and Liu, Jun},
  title   = {{Deciphering the Roles of Metformin in Alzheimer's Disease: A Snapshot}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.728315},
  pmid    = {35153733},
  url     = {https://doi.org/10.3389/fphar.2021.728315}
}

@article{kakoti2022-36263141,
  author  = {Kakoti, Bibhuti Bhusan and Bezbaruah, Rajashri and Ahmed, Nasima},
  title   = {{Therapeutic drug repositioning with special emphasis on neurodegenerative diseases: Threats and issues}},
  journal = {Frontiers in pharmacology},
  year    = {2022},
  doi     = {10.3389/fphar.2022.1007315},
  pmid    = {36263141},
  url     = {https://doi.org/10.3389/fphar.2022.1007315}
}

@article{chen2022-35401820,
  author  = {Chen, Sheng and Gan, Donghao and Lin, Sixiong and Zhong, Yiming and Chen, Mingjue and Zou, Xuenong and Shao, Zengwu and Xiao, Guozhi},
  title   = {{Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms}},
  journal = {Theranostics},
  year    = {2022},
  doi     = {10.7150/thno.71360},
  pmid    = {35401820},
  url     = {https://doi.org/10.7150/thno.71360}
}

@article{eshraghi2022-35304223,
  author  = {Eshraghi, Mehdi and Ahmadi, Mazaher and Afshar, Saeid and Lorzadeh, Shahrokh and Adlimoghaddam, Aida and Jalal, Nahid Rezvani and West, Ryan and Dastghaib, Sanaz and others},
  title   = {{Enhancing autophagy in Alzheimer's disease through drug repositioning}},
  journal = {Pharmacology \& therapeutics},
  year    = {2022},
  doi     = {10.1016/j.pharmthera.2022.108171},
  pmid    = {35304223},
  url     = {https://doi.org/10.1016/j.pharmthera.2022.108171}
}

@article{bayraktar2023-37210557,
  author  = {Bayraktar, Abdulahad and Li, Xiangyu and Kim, Woonghee and Zhang, Cheng and Turkez, Hasan and Shoaie, Saeed and Mardinoglu, Adil},
  title   = {{Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients}},
  journal = {Journal of translational medicine},
  year    = {2023},
  doi     = {10.1186/s12967-023-04192-6},
  pmid    = {37210557},
  url     = {https://doi.org/10.1186/s12967-023-04192-6}
}

@article{ashraf2022-35889524,
  author  = {Ashraf, Ghulam Md and DasGupta, Debarati and Alam, Mohammad Zubair and Baeesa, Saleh S and Alghamdi, Badrah S and Anwar, Firoz and Alqurashi, Thamer M A and Sharaf, Sharaf E and others},
  title   = {{Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2022},
  doi     = {10.3390/molecules27144652},
  pmid    = {35889524},
  url     = {https://doi.org/10.3390/molecules27144652}
}

@article{agarwal2023-35733313,
  author  = {Agarwal, Kritie and Katare, Deepshikha Pande and Jakhmola-Mani, Ruchi},
  title   = {{Foresee Novel Targets for Alzheimer's Disease by Investigating Repurposed Drugs}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2023},
  doi     = {10.2174/1871527321666220622162622},
  pmid    = {35733313},
  url     = {https://doi.org/10.2174/1871527321666220622162622}
}

@article{sanati2022-34999113,
  author  = {Sanati, Mehdi and Aminyavari, Samaneh and Afshari, Amir R and Sahebkar, Amirhossein},
  title   = {{Mechanistic insight into the role of metformin in Alzheimer's disease}},
  journal = {Life sciences},
  year    = {2022},
  doi     = {10.1016/j.lfs.2021.120299},
  pmid    = {34999113},
  url     = {https://doi.org/10.1016/j.lfs.2021.120299}
}

@article{haussmann2021-34119602,
  author  = {Haussmann, Robert and Noppes, Felix and Brandt, Moritz D and Bauer, Michael and Donix, Markus},
  title   = {{Lithium: A therapeutic option in Alzheimer's disease and its prodromal stages?}},
  journal = {Neuroscience letters},
  year    = {2021},
  doi     = {10.1016/j.neulet.2021.136044},
  pmid    = {34119602},
  url     = {https://doi.org/10.1016/j.neulet.2021.136044}
}

@article{oliveira2021-34283253,
  author  = {Oliveira, Wilma Helena and Braga, Clarissa Figueiredo and Lós, Deniele Bezerra and Araújo, Shyrlene Meiry Rocha and França, MariaEduarda Rocha and Duarte-Silva, Eduardo and Rodrigues, Gabriel Barros and Rocha, Sura Wanessa Santos and others},
  title   = {{Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice}},
  journal = {Experimental brain research},
  year    = {2021},
  doi     = {10.1007/s00221-021-06176-8},
  pmid    = {34283253},
  url     = {https://doi.org/10.1007/s00221-021-06176-8}
}

@article{alkuraishy2023-36849855,
  author  = {Al-Kuraishy, Hayder M and Al-Gareeb, Ali I and Saad, Hebatallah M and Batiha, Gaber El-Saber},
  title   = {{Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects}},
  journal = {Inflammopharmacology},
  year    = {2023},
  doi     = {10.1007/s10787-023-01163-7},
  pmid    = {36849855},
  url     = {https://doi.org/10.1007/s10787-023-01163-7}
}

@article{muronaga2022-36073313,
  author  = {Muronaga, Masaaki and Terao, Takeshi and Kohno, Kentaro and Hirakawa, Hirofumi and Izumi, Toshihiko and Etoh, Masaki},
  title   = {{Lithium in drinking water and Alzheimer's dementia: Epidemiological Findings from National Data Base of Japan}},
  journal = {Bipolar disorders},
  year    = {2022},
  doi     = {10.1111/bdi.13257},
  pmid    = {36073313},
  url     = {https://doi.org/10.1111/bdi.13257}
}

@article{zhu2022-35765655,
  author  = {Zhu, Sha and Bai, Qifeng and Li, Lanqing and Xu, Tingyang},
  title   = {{Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents}},
  journal = {Computational and structural biotechnology journal},
  year    = {2022},
  doi     = {10.1016/j.csbj.2022.05.057},
  pmid    = {35765655},
  url     = {https://doi.org/10.1016/j.csbj.2022.05.057}
}

@article{chen2021-34717542,
  author  = {Chen, Peng and Bao, Tianjiazhi and Yu, Xiaosheng and Liu, Zhongtu},
  title   = {{A drug repositioning algorithm based on a deep autoencoder and adaptive fusion}},
  journal = {BMC bioinformatics},
  year    = {2021},
  doi     = {10.1186/s12859-021-04406-y},
  pmid    = {34717542},
  url     = {https://doi.org/10.1186/s12859-021-04406-y}
}

@article{benjanuwattra2020-32621957,
  author  = {Benjanuwattra, Juthipong and Apaijai, Nattayaporn and Chunchai, Titikorn and Kerdphoo, Sasiwan and Jaiwongkam, Thidarat and Arunsak, Bussarin and Wongsuchai, Supawit and Chattipakorn, Nipon and others},
  title   = {{Metformin preferentially provides neuroprotection following cardiac ischemia/reperfusion in non-diabetic rats}},
  journal = {Biochimica et biophysica acta. Molecular basis of disease},
  year    = {2020},
  doi     = {10.1016/j.bbadis.2020.165893},
  pmid    = {32621957},
  url     = {https://doi.org/10.1016/j.bbadis.2020.165893}
}

@article{makeeva2023-38069121,
  author  = {Makeeva, Vladlena S and Dyrkheeva, Nadezhda S and Lavrik, Olga I and Zakian, Suren M and Malakhova, Anastasia A},
  title   = {{Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms242316798},
  pmid    = {38069121},
  url     = {https://doi.org/10.3390/ijms242316798}
}

@article{matuszewski2026-fe439787,
  author  = {Matuszewski, W. and Wołos-Kłosowicz, K. and Włodarczyk, P. and Waśniewska, P. and Modzelewski, R. and Górny, J. M. and Szklarz, M. and Juranek, J.},
  title   = {{Beyond Glycemic Control: GLP-1RA–Based Therapies and Emerging Targets Beyond the Metabolic Axis}},
  journal = {Journal of clinical medicine},
  year    = {2026},
  doi     = {10.20944/preprints202602.0277.v1},
  url     = {https://doi.org/10.20944/preprints202602.0277.v1}
}

@article{jantrapirom2020-32138327,
  author  = {Jantrapirom, Salinee and Nimlamool, Wutigri and Chattipakorn, Nipon and Chattipakorn, Siriporn Chaisin and Temviriyanukul, Piya and Inthachat, Woorawee and Govitrapong, Piyarat and Potikanond, Saranyapin},
  title   = {{Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity}},
  journal = {International Journal of Molecular Sciences},
  year    = {2020},
  doi     = {10.3390/ijms21051725},
  pmid    = {32138327},
  url     = {https://doi.org/10.3390/ijms21051725}
}

@article{panagaki2017-29170452,
  author  = {Panagaki, Theodora and Michael, Maria and Hölscher, Christian},
  title   = {{Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells}},
  journal = {Scientific Reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-16488-x},
  pmid    = {29170452},
  url     = {https://doi.org/10.1038/s41598-017-16488-x}
}

@article{elsahar2020-33125461,
  author  = {El-Sahar, Ayman E. and Shiha, Nesma A. and El Sayed, Nesrine S. and Ahmed, Lamiaa A.},
  title   = {{Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways}},
  journal = {The International Journal of Neuropsychopharmacology},
  year    = {2020},
  doi     = {10.1093/ijnp/pyaa078},
  pmid    = {33125461},
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