% alzhub.org library filter
% Source: https://alzhub.org/research?category=drug_development
% 500 entries, in the order the page lists them. Built from alzhub.org's own records.
% 1 entries have no readable author in the source record and carry no author field.

@article{nong2025-40813122,
  author  = {Nong, Kailei and Jeppesen, Britta Tendal and Shi, Qingyang and Agoritsas, Thomas and Guyatt, Gordon H and White, Heath and Gao, Yiyuan and Agarwal, Arnav and others},
  title   = {{Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2025},
  doi     = {10.1136/bmj-2024-083039},
  pmid    = {40813122},
  url     = {https://doi.org/10.1136/bmj-2024-083039}
}

@article{huang2024-38743015,
  author  = {Huang, Qing and Ma, Xue-Qin and Chen, Hui-Fang},
  title   = {{Lithium Exposure and Risk of Major Neurocognitive Disorders: A Systematic Review and Meta-analysis}},
  journal = {Journal of clinical psychopharmacology},
  year    = {2024},
  doi     = {10.1097/jcp.0000000000001863},
  pmid    = {38743015},
  url     = {https://doi.org/10.1097/jcp.0000000000001863}
}

@article{shulman2023-38012285,
  author  = {Shulman, M. and Kong, J. and O'Gorman, J. and Ratti, E. and Rajagovindan, R. and Viollet, L. and Huang, E. and Sharma, S. and others},
  title   = {{TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease}},
  journal = {Nature aging},
  year    = {2023},
  doi     = {10.1038/s43587-023-00523-w},
  pmid    = {38012285},
  url     = {https://doi.org/10.1038/s43587-023-00523-w}
}

@article{tseng2025-40189519,
  author  = {Tseng, Ping-Tao and Zeng, Bing-Yan and Hsu, Chih-Wei and Hung, Chao-Ming and Carvalho, Andre F and Stubbs, Brendon and Chen, Yen-Wen and Chen, Tien-Yu and others},
  title   = {{The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis}},
  journal = {BMC medicine},
  year    = {2025},
  doi     = {10.1186/s12916-025-04018-w},
  pmid    = {40189519},
  url     = {https://doi.org/10.1186/s12916-025-04018-w}
}

@article{abdelhaleem2026-40435316,
  author  = {Abdel-Haleem, Alyaa M and Casavant, Ellen and Toth, Balazs and Teng, Edmond and Monteiro, Cecilia and Pandya, Nikhil J and Glock, Caspar and Hoogenraad, Casper C and others},
  title   = {{CSF proteomics of semorinemab Alzheimer's disease trials identifies cell-type specific signatures}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awaf200},
  pmid    = {40435316},
  url     = {https://doi.org/10.1093/brain/awaf200}
}

@article{biessels2019-31399442,
  author  = {Biessels, G. J. and Verhagen, C. and Janssen, J. and van den Berg, E. and Zinman, B. and Rosenstock, J. and George, J. T. and Passera, A. and others},
  title   = {{Effect of Linagliptin on Cognitive Performance in Patients With Type 2 Diabetes and Cardiorenal Comorbidities: The CARMELINA Randomized Trial}},
  journal = {Diabetes care},
  year    = {2019},
  doi     = {10.2337/dc19-0783},
  pmid    = {31399442},
  url     = {https://doi.org/10.2337/dc19-0783}
}

@article{liang2024-38746639,
  author  = {Liang, Y. and Doré, V. and Rowe, C. C. and Krishnadas, N.},
  title   = {{Clinical Evidence for GLP-1 Receptor Agonists in Alzheimer's Disease: A Systematic Review}},
  journal = {Journal of Alzheimer's disease reports},
  year    = {2024},
  doi     = {10.3233/adr-230181},
  pmid    = {38746639},
  url     = {https://doi.org/10.3233/adr-230181}
}

@article{burns2025-40566796,
  author  = {Burns, Jeffrey M and Morris, Jill K and Vidoni, Eric D and Wilkins, Heather M and Choi, In-Young and Lee, Phil and Hunt, Suzanne L and Mahnken, Jonathan D and others},
  title   = {{Effects of the SGLT2 inhibitor dapagliflozin in early Alzheimer's disease: A randomized controlled trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70416},
  pmid    = {40566796},
  url     = {https://doi.org/10.1002/alz.70416}
}

@article{roselldiaz2024-38871078,
  author  = {Rosell-Díaz, Marisel and Petit-Gay, Anna and Molas-Prat, Clàudia and Gallardo-Nuell, Laura and Ramió-Torrentà, Lluís and Garre-Olmo, Josep and Pérez-Brocal, Vicente and Moya, Andrés and others},
  title   = {{Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men}},
  journal = {Metabolism: clinical and experimental},
  year    = {2024},
  doi     = {10.1016/j.metabol.2024.155941},
  pmid    = {38871078},
  url     = {https://doi.org/10.1016/j.metabol.2024.155941}
}

@article{devanand2022-34059401,
  author  = {Devanand, D P and Crocco, Elizabeth and Forester, Brent P and Husain, Mustafa M and Lee, Seonjoo and Vahia, Ipsit V and Andrews, Howard and Simon-Pearson, Laura and others},
  title   = {{Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease: Lit-AD Randomized Clinical Trial}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2022},
  doi     = {10.1016/j.jagp.2021.04.014},
  pmid    = {34059401},
  url     = {https://doi.org/10.1016/j.jagp.2021.04.014}
}

@article{gauthier2016-27863809,
  author  = {Gauthier, S. and Feldman, H. H. and Schneider, L. S. and Wilcock, G. K. and Frisoni, G. B. and Hardlund, J. H. and Moebius, H. J. and others},
  title   = {{Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial}},
  journal = {Lancet (London, England)},
  year    = {2016},
  doi     = {10.1016/s0140-6736(16)31275-2},
  pmid    = {27863809},
  url     = {https://doi.org/10.1016/s0140-6736(16)31275-2}
}

@article{tang2023-36821780,
  author  = {Tang, H. and Shao, H. and Shaaban, C. E. and Yang, K. and Brown, J. and Anton, S. and Wu, Y. and Bress, A. and others},
  title   = {{Newer glucose-lowering drugs and risk of dementia: A systematic review and meta-analysis of observational studies}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2023},
  doi     = {10.1111/jgs.18306},
  pmid    = {36821780},
  url     = {https://doi.org/10.1111/jgs.18306}
}

@article{fang2021-35572351,
  author  = {Fang, J. and Zhang, P. and Zhou, Y. and Chiang, C. W. and Tan, J. and Hou, Y. and Stauffer, S. and Li, L. and others},
  title   = {{Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease}},
  journal = {Nature aging},
  year    = {2021},
  doi     = {10.1038/s43587-021-00138-z},
  pmid    = {35572351},
  url     = {https://doi.org/10.1038/s43587-021-00138-z}
}

@article{choudhury2026-41862354,
  author  = {Choudhury, Ishraq and Ward, John Headly and Mahesh, Sahana and Alam, Uazman and Azmi, Shazli and Anson, Matthew},
  title   = {{Effect of Glucagon-Like-Peptide-1 Receptor Agonists (GLP-1 RA) on Neuropsychiatric Outcomes: A Systematic Review and Meta-Analysis}},
  journal = {Clinical therapeutics},
  year    = {2026},
  doi     = {10.1016/j.clinthera.2026.02.010},
  pmid    = {41862354},
  url     = {https://doi.org/10.1016/j.clinthera.2026.02.010}
}

@article{cas2024-38565814,
  author  = {Cas, A Dei and Micheli, M M and Aldigeri, R and Gardini, S and Ferrari-Pellegrini, F and Perini, M and Messa, G and Antonini, M and others},
  title   = {{Long-acting exenatide does not prevent cognitive decline in mild cognitive impairment: a proof-of-concept clinical trial}},
  journal = {Journal of endocrinological investigation},
  year    = {2024},
  doi     = {10.1007/s40618-024-02320-7},
  pmid    = {38565814},
  url     = {https://doi.org/10.1007/s40618-024-02320-7}
}

@article{koychev2024-39358806,
  author  = {Koychev, Ivan and Reid, Graham and Nguyen, Maggie and Mentz, Robert J and Joyce, Dan and Shah, Svati H and Holman, Rury R},
  title   = {{Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01573-x},
  pmid    = {39358806},
  url     = {https://doi.org/10.1186/s13195-024-01573-x}
}

@article{zhou2020-32446679,
  author  = {Zhou, J. B. and Tang, X. and Han, M. and Yang, J. and Simó, R.},
  title   = {{Impact of antidiabetic agents on dementia risk: A Bayesian network meta-analysis}},
  journal = {Metabolism: clinical and experimental},
  year    = {2020},
  doi     = {10.1016/j.metabol.2020.154265},
  pmid    = {32446679},
  url     = {https://doi.org/10.1016/j.metabol.2020.154265}
}

@article{kuatedefo2024-37869901,
  author  = {Kuate Defo, A. and Bakula, V. and Pisaturo, A. and Labos, C. and Wing, S. S. and Daskalopoulou, S. S.},
  title   = {{Diabetes, antidiabetic medications and risk of dementia: A systematic umbrella review and meta-analysis}},
  journal = {Diabetes, obesity \& metabolism},
  year    = {2024},
  doi     = {10.1111/dom.15331},
  pmid    = {37869901},
  url     = {https://doi.org/10.1111/dom.15331}
}

@article{yasar2013-23911756,
  author  = {Yasar, S. and Xia, J. and Yao, W. and Furberg, C. D. and Xue, Q. L. and Mercado, C. I. and Fitzpatrick, A. L. and Fried, L. P. and others},
  title   = {{Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study}},
  journal = {Neurology},
  year    = {2013},
  doi     = {10.1212/wnl.0b013e3182a35228},
  pmid    = {23911756},
  url     = {https://doi.org/10.1212/wnl.0b013e3182a35228}
}

@article{degiorgi2024-39764175,
  author  = {De Giorgi, Riccardo and Koychev, Ivan and Adler, Amanda I and Cowen, Philip J and Harmer, Catherine J and Harrison, Paul J and Taquet, Maxime},
  title   = {{12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes: a propensity-score matched cohort study}},
  journal = {EClinicalMedicine},
  year    = {2024},
  doi     = {10.1016/j.eclinm.2024.102726},
  pmid    = {39764175},
  url     = {https://doi.org/10.1016/j.eclinm.2024.102726}
}

@article{garciacasares2023-37231200,
  author  = {García-Casares, Natalia and González-González, Guillermo and de la Cruz-Cosme, Carlos and Garzón-Maldonado, Francisco J and de Rojas-Leal, Carmen and Ariza, María J and Narváez, Manuel and Barbancho, Miguel Ángel and others},
  title   = {{Effects of GLP-1 receptor agonists on neurological complications of diabetes}},
  journal = {Reviews in endocrine \& metabolic disorders},
  year    = {2023},
  doi     = {10.1007/s11154-023-09807-3},
  pmid    = {37231200},
  url     = {https://doi.org/10.1007/s11154-023-09807-3}
}

@article{zhou2021-33614900,
  author  = {Zhou, Bo and Zissimopoulos, Julie and Nadeem, Hasan and Crane, Matthew A and Goldman, Dana and Romley, John A},
  title   = {{Association between exenatide use and incidence of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12139},
  pmid    = {33614900},
  url     = {https://doi.org/10.1002/trc2.12139}
}

@article{lu2024-38657568,
  author  = {Lu, Qiuying and Lv, Huijing and Liu, Xiaotong and Zang, Lili and Zhang, Yue and Meng, Qinghui},
  title   = {{Lithium Therapy's Potential to Lower Dementia Risk and the Prevalence of Alzheimer's Disease: A Meta-Analysis}},
  journal = {European neurology},
  year    = {2024},
  doi     = {10.1159/000538846},
  pmid    = {38657568},
  url     = {https://doi.org/10.1159/000538846}
}

@article{gejl2017-29235507,
  author  = {Gejl, M. and Brock, B. and Egefjord, L. and Vang, K. and Rungby, J. and Gjedde, A.},
  title   = {{Blood-Brain Glucose Transfer in Alzheimer's disease: Effect of GLP-1 Analog Treatment}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-17718-y},
  pmid    = {29235507},
  url     = {https://doi.org/10.1038/s41598-017-17718-y}
}

@article{cao2018-29790638,
  author  = {Cao, B. and Rosenblat, J. D. and Brietzke, E. and Park, C. and Lee, Y. and Musial, N. and Pan, Z. and Mansur, R. B. and others},
  title   = {{Comparative efficacy and acceptability of antidiabetic agents for Alzheimer's disease and mild cognitive impairment: A systematic review and network meta-analysis}},
  journal = {Diabetes, obesity \& metabolism},
  year    = {2018},
  doi     = {10.1111/dom.13373},
  pmid    = {29790638},
  url     = {https://doi.org/10.1111/dom.13373}
}

@article{simons2002-12205648,
  author  = {Simons, M. and Schwärzler, F. and Lütjohann, D. and von Bergmann, K. and Beyreuther, K. and Dichgans, J. and Wormstall, H. and Hartmann, T. and others},
  title   = {{Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial}},
  journal = {Annals of neurology},
  year    = {2002},
  doi     = {10.1002/ana.10292},
  pmid    = {12205648},
  url     = {https://doi.org/10.1002/ana.10292}
}

@article{ott2015-25575908,
  author  = {Ott, B. R. and Daiello, L. A. and Dahabreh, I. J. and Springate, B. A. and Bixby, K. and Murali, M. and Trikalinos, T. A.},
  title   = {{Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials}},
  journal = {Journal of general internal medicine},
  year    = {2015},
  doi     = {10.1007/s11606-014-3115-3},
  pmid    = {25575908},
  url     = {https://doi.org/10.1007/s11606-014-3115-3}
}

@article{swiger2013-24095248,
  author  = {Swiger, K. J. and Manalac, R. J. and Blumenthal, R. S. and Blaha, M. J. and Martin, S. S.},
  title   = {{Statins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects}},
  journal = {Mayo Clinic proceedings},
  year    = {2013},
  doi     = {10.1016/j.mayocp.2013.07.013},
  pmid    = {24095248},
  url     = {https://doi.org/10.1016/j.mayocp.2013.07.013}
}

@article{forlenza2019-30947755,
  author  = {Forlenza, Orestes V and Radanovic, Márcia and Talib, Leda L and Gattaz, Wagner F},
  title   = {{Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2019},
  doi     = {10.1192/bjp.2019.76},
  pmid    = {30947755},
  url     = {https://doi.org/10.1192/bjp.2019.76}
}

@article{deliyannides2023-37732619,
  author  = {Deliyannides, Deborah A and Graff, Jamie A and Niño, Izael and Lee, Seonjoo and Husain, Mustafa M and Forester, Brent P and Crocco, Elizabeth and Vahia, Ipsit V and others},
  title   = {{Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation}},
  journal = {International journal of geriatric psychiatry},
  year    = {2023},
  doi     = {10.1002/gps.6002},
  pmid    = {37732619},
  url     = {https://doi.org/10.1002/gps.6002}
}

@article{norgaard2022-35229024,
  author  = {Nørgaard, C. H. and Friedrich, S. and Hansen, C. T. and Gerds, T. and Ballard, C. and Møller, D. V. and Knudsen, L. B. and Kvist, K. and others},
  title   = {{Treatment with glucagon-like peptide-1 receptor agonists and incidence of dementia: Data from pooled double-blind randomized controlled trials and nationwide disease and prescription registers}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12268},
  pmid    = {35229024},
  url     = {https://doi.org/10.1002/trc2.12268}
}

@article{siddeeque2024-39486172,
  author  = {Siddeeque, N. and Hussein, M. H. and Abdelmaksoud, A. and Bishop, J. and Attia, A. S. and Elshazli, R. M. and Fawzy, M. S. and Toraih, E. A.},
  title   = {{Neuroprotective effects of GLP-1 receptor agonists in neurodegenerative Disorders: A Large-Scale Propensity-Matched cohort study}},
  journal = {International immunopharmacology},
  year    = {2024},
  doi     = {10.1016/j.intimp.2024.113537},
  pmid    = {39486172},
  url     = {https://doi.org/10.1016/j.intimp.2024.113537}
}

@article{luchsinger2016-26890736,
  author  = {Luchsinger, J. A. and Perez, T. and Chang, H. and Mehta, P. and Steffener, J. and Pradabhan, G. and Ichise, M. and Manly, J. and others},
  title   = {{Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2016},
  doi     = {10.3233/jad-150493},
  pmid    = {26890736},
  url     = {https://doi.org/10.3233/jad-150493}
}

@article{engstrom2026-41994910,
  author  = {Engström, Arvid and Svanström, Henrik and Hviid, Anders and Eliasson, Björn and Gudbjörnsdottir, Soffia and Wintzell, Viktor and Hveem, Kristian and Jonasson, Christian and others},
  title   = {{Use of Glucagon-Like Peptide-1 Receptor Agonists and Risk of Parkinson's Disease: Scandinavian Cohort Study}},
  journal = {Diabetes, obesity \& metabolism},
  year    = {2026},
  doi     = {10.1111/dom.70760},
  pmid    = {41994910},
  url     = {https://doi.org/10.1111/dom.70760}
}

@article{dai2022-36186728,
  author  = {Dai, Jiahui and Ports, Kayleen Deanna and Corrada, Maria M and Odegaard, Andrew O and O'Connell, Joan and Jiang, Luohua},
  title   = {{Metformin and Dementia Risk: A Systematic Review with Respect to Time Related Biases}},
  journal = {Journal of Alzheimer's disease reports},
  year    = {2022},
  doi     = {10.3233/adr-220002},
  pmid    = {36186728},
  url     = {https://doi.org/10.3233/adr-220002}
}

@article{avilesolmos2014-24662192,
  author  = {Aviles-Olmos, I. and Dickson, J. and Kefalopoulou, Z. and Djamshidian, A. and Kahan, J. and Ell, P. and Whitton, P. and Wyse, R. and others},
  title   = {{Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease}},
  journal = {Journal of Parkinson's disease},
  year    = {2014},
  doi     = {10.3233/jpd-140364},
  pmid    = {24662192},
  url     = {https://doi.org/10.3233/jpd-140364}
}

@article{tian2023-37302139,
  author  = {Tian, S. and Jiang, J. and Wang, J. and Zhang, Z. and Miao, Y. and Ji, X. and Bi, Y.},
  title   = {{Comparison on cognitive outcomes of antidiabetic agents for type 2 diabetes: A systematic review and network meta-analysis}},
  journal = {Diabetes/metabolism research and reviews},
  year    = {2023},
  doi     = {10.1002/dmrr.3673},
  pmid    = {37302139},
  url     = {https://doi.org/10.1002/dmrr.3673}
}

@article{forlenza2011-21525519,
  author  = {Forlenza, O. V. and Diniz, B. S. and Radanovic, M. and Santos, F. S. and Talib, L. L. and Gattaz, W. F.},
  title   = {{Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2011},
  doi     = {10.1192/bjp.bp.110.080044},
  pmid    = {21525519},
  url     = {https://doi.org/10.1192/bjp.bp.110.080044}
}

@article{laurindo2022-35054924,
  author  = {Laurindo, L. F. and Barbalho, S. M. and Guiguer, E. L. and da Silva Soares de Souza, M. and de Souza, G. A. and Fidalgo, T. M. and Araújo, A. C. and de Souza Gonzaga, H. F. and others},
  title   = {{GLP-1a: Going beyond Traditional Use}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23020739},
  pmid    = {35054924},
  url     = {https://doi.org/10.3390/ijms23020739}
}

@article{wagstaff2003-12885101,
  author  = {Wagstaff, L. R. and Mitton, M. W. and Arvik, B. M. and Doraiswamy, P. M.},
  title   = {{Statin-associated memory loss: analysis of 60 case reports and review of the literature}},
  journal = {Pharmacotherapy},
  year    = {2003},
  doi     = {10.1592/phco.23.7.871.32720},
  pmid    = {12885101},
  url     = {https://doi.org/10.1592/phco.23.7.871.32720}
}

@article{trompet2010-19653027,
  author  = {Trompet, S. and van Vliet, P. and de Craen, A. J. and Jolles, J. and Buckley, B. M. and Murphy, M. B. and Ford, I. and Macfarlane, P. W. and others},
  title   = {{Pravastatin and cognitive function in the elderly. Results of the PROSPER study}},
  journal = {Journal of neurology},
  year    = {2010},
  doi     = {10.1007/s00415-009-5271-7},
  pmid    = {19653027},
  url     = {https://doi.org/10.1007/s00415-009-5271-7}
}

@article{cheng2017-28002662,
  author  = {Cheng, Chin and Zandi, Peter and Stuart, Elizabeth and Lin, Ching-Heng and Su, Pei-Yu and Alexander, G Caleb and Lan, Tsuo-Hung},
  title   = {{Association Between Lithium Use and Risk of Alzheimer's Disease}},
  journal = {The Journal of clinical psychiatry},
  year    = {2017},
  doi     = {10.4088/jcp.15m10304},
  pmid    = {28002662},
  url     = {https://doi.org/10.4088/jcp.15m10304}
}

@article{terao2024-39598397,
  author  = {Terao, Takeshi and Hirakawa, Hirofumi and Muronaga, Masaaki and Izumi, Toshihiko and Kohno, Kentaro},
  title   = {{Trace Lithium for Suicide Prevention and Dementia Prevention: A Qualitative Review}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2024},
  doi     = {10.3390/ph17111486},
  pmid    = {39598397},
  url     = {https://doi.org/10.3390/ph17111486}
}

@article{araki2020-7f71ce0b,
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  url     = {https://doi.org/10.1186/s13024-024-00733-9}
}

@article{gaikwad2024-38959324,
  author  = {Gaikwad, Sagar and Puangmalai, Nicha and Sonawane, Minal and Montalbano, Mauro and Price, Rachel and Iyer, Malini S and Ray, Anamika and Moreno, Sandra and others},
  title   = {{Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adj5958},
  pmid    = {38959324},
  url     = {https://doi.org/10.1126/scitranslmed.adj5958}
}

@article{olluri2025-39908690,
  author  = {Olluri, Andi},
  title   = {{Clinical trials targeting tau should be halted}},
  journal = {Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year    = {2025},
  doi     = {10.1016/j.jocn.2025.111101},
  pmid    = {39908690},
  url     = {https://doi.org/10.1016/j.jocn.2025.111101}
}

@article{weber2024-38763001,
  author  = {Weber, Patrick and Bojarová, Pavla and Brouzdová, Jitka and Křen, Vladimír and Kulik, Natalia and Stütz, Arnold E and Thonhofer, Martin and Wrodnigg, Tanja M},
  title   = {{Diaminocyclopentane - l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase}},
  journal = {Bioorganic chemistry},
  year    = {2024},
  doi     = {10.1016/j.bioorg.2024.107452},
  pmid    = {38763001},
  url     = {https://doi.org/10.1016/j.bioorg.2024.107452}
}

@article{jang2024-39500576,
  author  = {Jang, Elliot and Hoxha, Kevt'her and Mozier, Damian and Insana, Abigail and Farber, Ethan and Changolkar, Lakshmi and Zhang, Bin and Chio, Tak-Ian and others},
  title   = {{Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2024},
  doi     = {10.1523/jneurosci.0877-24.2024},
  pmid    = {39500576},
  url     = {https://doi.org/10.1523/jneurosci.0877-24.2024}
}

@article{thangwaritorn2024-38756263,
  author  = {Thangwaritorn, Skylynn and Lee, Christopher and Metchikoff, Elena and Razdan, Vidushi and Ghafary, Suliman and Rivera, Dominic and Pinto, Alvaro and Pemminati, Sudhakar},
  title   = {{A Review of Recent Advances in the Management of Alzheimer's Disease}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.58416},
  pmid    = {38756263},
  url     = {https://doi.org/10.7759/cureus.58416}
}

@article{horsley2024-38512662,
  author  = {Horsley, David and Rickard, Janet E and Vorley, Thomas and Leeper, Matilda F and Wischik, Claude M and Harrington, Charles R},
  title   = {{Assays for the Screening and Characterization of Tau Aggregation Inhibitors}},
  journal = {Methods in molecular biology (Clifton, N.J.)},
  year    = {2024},
  doi     = {10.1007/978-1-0716-3629-9_5},
  pmid    = {38512662},
  url     = {https://doi.org/10.1007/978-1-0716-3629-9_5}
}

@article{delgiudice2024-38508903,
  author  = {Del Giudice, Kirsys Patricia and Cosgaya, Marina and Zaro, Idoia and Ravasi, Valeria and Santacruz, Pilar and Painous, Celia and Fernández, Manel and Cámara, Ana and others},
  title   = {{Anti-alpha synuclein and anti-tau immunotherapies: Can a cocktail approach work?}},
  journal = {Parkinsonism \& related disorders},
  year    = {2024},
  doi     = {10.1016/j.parkreldis.2024.106080},
  pmid    = {38508903},
  url     = {https://doi.org/10.1016/j.parkreldis.2024.106080}
}

@article{zhang2025-41017406,
  author  = {Zhang, Han and Pan, Ming-Tian and Li, Yu-Xuan and Li, Xiao-Jiang and Guo, Xiang-Yu and He, Da-Jian},
  title   = {{Understanding Tau pathology: Insights from animal models}},
  journal = {Zoological research},
  year    = {2025},
  doi     = {10.24272/j.issn.2095-8137.2025.077},
  pmid    = {41017406},
  url     = {https://doi.org/10.24272/j.issn.2095-8137.2025.077}
}

@article{rosenqvist2018-30386817,
  author  = {Rosenqvist, Nina and Asuni, Ayodeji A and Andersson, Christian R and Christensen, Søren and Daechsel, Justus A and Egebjerg, Jan and Falsig, Jeppe and Helboe, Lone and others},
  title   = {{Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2018},
  doi     = {10.1016/j.trci.2018.09.005},
  pmid    = {30386817},
  url     = {https://doi.org/10.1016/j.trci.2018.09.005}
}

@article{schuster2024-38429929,
  author  = {Schuster, Kristen H and Zalon, Annie J and DiFranco, Danielle M and Putka, Alexandra F and Stec, Nicholas R and Jarrah, Sabrina I and Naeem, Arsal and Haque, Zaid and others},
  title   = {{ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice}},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year    = {2024},
  doi     = {10.1016/j.ymthe.2024.02.033},
  pmid    = {38429929},
  url     = {https://doi.org/10.1016/j.ymthe.2024.02.033}
}

@article{smith2024-38618323,
  author  = {Smith, Blake and Ownby, Raymond L},
  title   = {{Disease-Modifying Treatments and Their Future in Alzheimer's Disease Management}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.56105},
  pmid    = {38618323},
  url     = {https://doi.org/10.7759/cureus.56105}
}

@article{zhou2024-39613463,
  author  = {Zhou, Futao and Zhao, Yushi and Sun, Yangyan and Chen, Wanjiao},
  title   = {{Molecular Insights into Tau Pathology and its Therapeutic Strategies in Alzheimer's Disease}},
  journal = {Journal of integrative neuroscience},
  year    = {2024},
  doi     = {10.31083/j.jin2311197},
  pmid    = {39613463},
  url     = {https://doi.org/10.31083/j.jin2311197}
}

@article{shi2024-38255905,
  author  = {Shi, Huahua and Zhao, Yan},
  title   = {{Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25020831},
  pmid    = {38255905},
  url     = {https://doi.org/10.3390/ijms25020831}
}

@article{vejandla2024-38313929,
  author  = {Vejandla, Bhuvanasai and Savani, Sarah and Appalaneni, Rohith and Veeravalli, Rithik S and Gude, Sai Sravya},
  title   = {{Alzheimer's Disease: The Past, Present, and Future of a Globally Progressive Disease}},
  journal = {Cureus},
  year    = {2024},
  doi     = {10.7759/cureus.51705},
  pmid    = {38313929},
  url     = {https://doi.org/10.7759/cureus.51705}
}

@article{pawar2025-40395755,
  author  = {Pawar, Shreya and Rauf, Mohd Ahmar and Abdelhady, Hosam and Iyer, Arun K},
  title   = {{Tau-targeting nanoparticles for treatment of Alzheimer's disease}},
  journal = {Exploration (Beijing, China)},
  year    = {2025},
  doi     = {10.1002/exp.20230137},
  pmid    = {40395755},
  url     = {https://doi.org/10.1002/exp.20230137}
}

@article{godugu2025-41562774,
  author  = {Godugu, Deepika and Gattu, Kranthi and Suri, Parul and Daartey, Abel B and Jadhav, Krishna and Rojekar, Satish},
  title   = {{Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches}},
  journal = {Antibodies (Basel, Switzerland)},
  year    = {2025},
  doi     = {10.3390/antib15010001},
  pmid    = {41562774},
  url     = {https://doi.org/10.3390/antib15010001}
}

@article{bang2024-39634029,
  author  = {Bang, Sookhee and Song, Jeong Kuen and Lee, Kwan Hee},
  title   = {{Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer's diseases}},
  journal = {IBRO neuroscience reports},
  year    = {2024},
  doi     = {10.1016/j.ibneur.2024.11.005},
  pmid    = {39634029},
  url     = {https://doi.org/10.1016/j.ibneur.2024.11.005}
}

@article{tanabe2025-40276591,
  author  = {Tanabe, Hirokazu and Maeda, Sumihiro and Sano, Etsuko and Sakai, Norio and Endoh-Yamagami, Setsu and Okano, Hideyuki},
  title   = {{Tau aggregation induces cell death in iPSC-derived neurons}},
  journal = {Aging brain},
  year    = {2025},
  doi     = {10.1016/j.nbas.2025.100136},
  pmid    = {40276591},
  url     = {https://doi.org/10.1016/j.nbas.2025.100136}
}

@article{sabbagh2025-40782673,
  author  = {Sabbagh, Marwan Noel and Kennedy, Jessica and Majeed, Jad and Decourt, Boris},
  title   = {{Alzheimer's disease: Clinical trials to watch}},
  journal = {Med (New York, N.Y.)},
  year    = {2025},
  doi     = {10.1016/j.medj.2025.100771},
  pmid    = {40782673},
  url     = {https://doi.org/10.1016/j.medj.2025.100771}
}

@article{alshehri2025-40498212,
  author  = {Alshehri, Ghadah H and Al-Kuraishy, Hayder M and Waheed, Huda Jaber and Al-Gareeb, Ali I and Faheem, Safaa A and Alexiou, Athanasios and Papadakis, Marios and Batiha, Gaber El-Saber},
  title   = {{Tirzepatide: a novel therapeutic approach for Alzheimer's disease}},
  journal = {Metabolic brain disease},
  year    = {2025},
  doi     = {10.1007/s11011-025-01649-z},
  pmid    = {40498212},
  url     = {https://doi.org/10.1007/s11011-025-01649-z}
}

@article{zhou2025-40344943,
  author  = {Zhou, Zhi Dong and Yi, Lingxiao and Popławska-Domaszewicz, Karolina and Chaudhuri, Kallol Ray and Jankovic, Joseph and Tan, Eng King},
  title   = {{Glucagon-like peptide-1 receptor agonists in neurodegenerative diseases: Promises and challenges}},
  journal = {Pharmacological research},
  year    = {2025},
  doi     = {10.1016/j.phrs.2025.107770},
  pmid    = {40344943},
  url     = {https://doi.org/10.1016/j.phrs.2025.107770}
}

@article{himmerich2025-40042613,
  author  = {Himmerich, Hubertus},
  title   = {{[Glucagon-like peptide-1 receptor agonists: a new pharmacological treatment option for psychiatric illnesses?]}},
  journal = {Der Nervenarzt},
  year    = {2025},
  doi     = {10.1007/s00115-025-01813-x},
  pmid    = {40042613},
  url     = {https://doi.org/10.1007/s00115-025-01813-x}
}

@article{zarei2025-40620322,
  author  = {Zarei, Malek and Sabetkasaei, Masoumeh and Mozafari, Masoud and Zaeri, Sasan},
  title   = {{The expanding role of semaglutide: beyond glycemic control}},
  journal = {Journal of diabetes and metabolic disorders},
  year    = {2025},
  doi     = {10.1007/s40200-025-01663-z},
  pmid    = {40620322},
  url     = {https://doi.org/10.1007/s40200-025-01663-z}
}

@article{moaket2025-41226780,
  author  = {Moaket, Osama Sobhi and Obaid, Sarah Eyad and Obaid, Fawaz Eyad and Shakeeb, Yusuf Abdulkarim and Elsharief, Samir Mohammed and Tania, Afrin and Darwish, Radwan and Butler, Alexandra E and others},
  title   = {{GLP-1 and the Degenerating Brain: Exploring Mechanistic Insights and Therapeutic Potential}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms262110743},
  pmid    = {41226780},
  url     = {https://doi.org/10.3390/ijms262110743}
}

@article{west2025-40172827,
  author  = {West, Juliana and Li, Maggie and Wong, Sabrina and Le, Gia Han and Teopiz, Kayla M and Valentino, Kyle and Dri, Christine E and McIntyre, Roger S},
  title   = {{Are Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Central Nervous System (CNS) Penetrant: A Narrative Review}},
  journal = {Neurology and therapy},
  year    = {2025},
  doi     = {10.1007/s40120-025-00724-y},
  pmid    = {40172827},
  url     = {https://doi.org/10.1007/s40120-025-00724-y}
}

@article{pillarisetti2025-39902055,
  author  = {Pillarisetti, Lekha and Agrawal, Devendra K},
  title   = {{Semaglutide: Double-edged Sword with Risks and Benefits}},
  journal = {Archives of internal medicine research},
  year    = {2025},
  doi     = {10.26502/aimr.0189},
  pmid    = {39902055},
  url     = {https://doi.org/10.26502/aimr.0189}
}

@article{zhang2024-39405916,
  author  = {Zhang, Yinbing and Tang, Cheng and He, Yao and Zhang, Yingqian and Li, Qinxi and Zhang, Ting and Zhao, Bangcheng and Tong, Aiping and others},
  title   = {{Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and human brain organoid models}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2024},
  doi     = {10.1016/j.biopha.2024.117540},
  pmid    = {39405916},
  url     = {https://doi.org/10.1016/j.biopha.2024.117540}
}

@article{roy2025-40738791,
  author  = {Roy, Akash and Dawson, Valina L and Dawson, Ted M},
  title   = {{From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2025},
  doi     = {10.1016/j.neurot.2025.e00712},
  pmid    = {40738791},
  url     = {https://doi.org/10.1016/j.neurot.2025.e00712}
}

@article{germano2024-39216535,
  author  = {Germano, Leticia Forny and Koehler, Jacqueline A and Baggio, Laurie L and Cui, Fiona and Wong, Chi Kin and Rittig, Nikolaj and Cao, Xiemin and Matthews, Dianne and others},
  title   = {{The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice}},
  journal = {Molecular metabolism},
  year    = {2024},
  doi     = {10.1016/j.molmet.2024.102019},
  pmid    = {39216535},
  url     = {https://doi.org/10.1016/j.molmet.2024.102019}
}

@article{holscher2025-40938528,
  author  = {Hölscher, Christian},
  title   = {{Incretin Hormones GLP-1 and GIP Normalize Energy Utilization and Reduce Inflammation in the Brain in Alzheimer's Disease and Parkinson's Disease: From Repurposed GLP-1 Receptor Agonists to Novel Dual GLP-1/GIP Receptor Agonists as Potential Disease-Modifying Therapies}},
  journal = {CNS drugs},
  year    = {2025},
  doi     = {10.1007/s40263-025-01226-z},
  pmid    = {40938528},
  url     = {https://doi.org/10.1007/s40263-025-01226-z}
}

@article{zhang2025-40882702,
  author  = {Zhang, Meng-Wei and Zhou, Wan-Yi and Li, Xin-Yi and Xu, Zhi-Heng and Lin, Hua-Mei and Tang, Yi-Lin and Zhao, Jue and Chen, Chen and others},
  title   = {{GLP-1 receptor agonist semaglutide ameliorates motor deficits and tau pathology in the rTg4510s mouse model}},
  journal = {Neuropharmacology},
  year    = {2025},
  doi     = {10.1016/j.neuropharm.2025.110659},
  pmid    = {40882702},
  url     = {https://doi.org/10.1016/j.neuropharm.2025.110659}
}

@article{sawamura2025-40001315,
  author  = {Sawamura, Toshitaka and Karashima, Shigehiro and Ohmori, Ai and Kometani, Mitsuhiro and Yoneda, Takashi},
  title   = {{Impacts of tirzepatide on older patients with diminished β-cell function and dementia}},
  journal = {Geriatrics \& gerontology international},
  year    = {2025},
  doi     = {10.1111/ggi.70018},
  pmid    = {40001315},
  url     = {https://doi.org/10.1111/ggi.70018}
}

@article{schnell2024-38504284,
  author  = {Schnell, Oliver and Barnard-Kelly, Katharine and Battelino, Tadej and Ceriello, Antonio and Larsson, Helena Elding and Fernández-Fernández, Beatriz and Forst, Thomas and Frias, Juan-Pablo and others},
  title   = {{CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes}},
  journal = {Cardiovascular diabetology},
  year    = {2024},
  doi     = {10.1186/s12933-024-02180-8},
  pmid    = {38504284},
  url     = {https://doi.org/10.1186/s12933-024-02180-8}
}

@article{ibrahim2025-40964464,
  author  = {Ibrahim, Ruba and Kambal, Aya and Abdelmajeed, Mohammed A},
  title   = {{Glucagon-Like Peptide-1 Receptor Agonists in Neurodegenerative Diseases: A Comprehensive Review}},
  journal = {Cureus},
  year    = {2025},
  doi     = {10.7759/cureus.92441},
  pmid    = {40964464},
  url     = {https://doi.org/10.7759/cureus.92441}
}

@article{akita2024-38185192,
  author  = {Akita, Tomomi and Shimamura, Mizuki and Tezuka, Ayano and Takagi, Marina and Yamashita, Chikamasa},
  title   = {{GLP-1 derivatives with functional sequences transit and migrate through trigeminal neurons}},
  journal = {European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year    = {2024},
  doi     = {10.1016/j.ejpb.2024.114176},
  pmid    = {38185192},
  url     = {https://doi.org/10.1016/j.ejpb.2024.114176}
}

@article{abdulrazeq2024-39959894,
  author  = {Abdulrazeq, Hael and Taman, Mazen and Ali, Rohaid and Doberstein, Cody and Sullivan, Patricia and Sampath, Prakash and Telfeian, Albert and Gokaslan, Ziya and others},
  title   = {{GLP-1 Receptor Agonists: Beyond Diabetes-What the Neurosurgeon Needs to Know}},
  journal = {Neurosurgery practice},
  year    = {2024},
  doi     = {10.1227/neuprac.0000000000000098},
  pmid    = {39959894},
  url     = {https://doi.org/10.1227/neuprac.0000000000000098}
}

@article{barrett2024-38915346,
  author  = {Barrett, Emma and Ivey, Gabrielle and Cunningham, Adam and Coffman, Gary and Pemberton, Tyera and Lee, Chan and Patra, Prabir and Day, James B and others},
  title   = {{Reduced GLP-1R availability in the caudate nucleus with Alzheimer's disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2024},
  doi     = {10.3389/fnagi.2024.1350239},
  pmid    = {38915346},
  url     = {https://doi.org/10.3389/fnagi.2024.1350239}
}

@article{crook2024-39422964,
  author  = {Crook, Harry and Edison, Paul},
  title   = {{Incretin Mimetics as Potential Disease Modifying Treatment for Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-240730},
  pmid    = {39422964},
  url     = {https://doi.org/10.3233/jad-240730}
}

@article{kopp2024-39062586,
  author  = {Kopp, Katherine O and Li, Yazhou and Glotfelty, Elliot J and Tweedie, David and Greig, Nigel H},
  title   = {{Incretin-Based Multi-Agonist Peptides Are Neuroprotective and Anti-Inflammatory in Cellular Models of Neurodegeneration}},
  journal = {Biomolecules},
  year    = {2024},
  doi     = {10.3390/biom14070872},
  pmid    = {39062586},
  url     = {https://doi.org/10.3390/biom14070872}
}

@article{sasaki2024-39577079,
  author  = {Sasaki, Kana and Fujita, Hiroki and Sato, Takehiro and Kato, Shunske and Takahashi, Yuya and Takeshita, Yukio and Kanda, Takashi and Saito, Takashi and others},
  title   = {{GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2024},
  doi     = {10.1016/j.bbrc.2024.151016},
  pmid    = {39577079},
  url     = {https://doi.org/10.1016/j.bbrc.2024.151016}
}

@article{sundararaman2025-40142784,
  author  = {Sundararaman, Lalitha and Gouda, Divakara and Kumar, Anil and Sundararaman, Sumithra and Goudra, Basavana},
  title   = {{Glucagon-like Peptide-1 Receptor Agonists: Exciting Avenues Beyond Weight Loss}},
  journal = {Journal of clinical medicine},
  year    = {2025},
  doi     = {10.3390/jcm14061978},
  pmid    = {40142784},
  url     = {https://doi.org/10.3390/jcm14061978}
}

@article{lv2024-39321702,
  author  = {Lv, Renjun and Zhao, Yan and Wang, Xiao and He, Yao and Dong, Na and Min, Xiangzhen and Liu, Xueying and Yu, Qin and others},
  title   = {{GLP-1 analogue liraglutide attenuates CIH-induced cognitive deficits by inhibiting oxidative stress, neuroinflammation, and apoptosis via the Nrf2/HO-1 and MAPK/NF-κB signaling pathways}},
  journal = {International immunopharmacology},
  year    = {2024},
  doi     = {10.1016/j.intimp.2024.113222},
  pmid    = {39321702},
  url     = {https://doi.org/10.1016/j.intimp.2024.113222}
}

@article{stefano2025-41047006,
  author  = {Stefano, George B and Büttiker, Pascal and Weissenberger, Simon and Raboch, Jiri and Anders, Martin},
  title   = {{Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria}},
  journal = {Frontiers in neuroendocrinology},
  year    = {2025},
  doi     = {10.1016/j.yfrne.2025.101217},
  pmid    = {41047006},
  url     = {https://doi.org/10.1016/j.yfrne.2025.101217}
}

@article{office2025-40429612,
  author  = {Office, Internation Journal Of Molecular Sciences Editorial},
  title   = {{Expression of Concern: Paladugu et al. Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer's Disease. Int. J. Mol. Sci. 2021, 22, 860}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26104467},
  pmid    = {40429612},
  url     = {https://doi.org/10.3390/ijms26104467}
}

@article{noto2025-41035821,
  author  = {Noto, Natalia Motzko and Speth, Robert C and Robison, Lisa S},
  title   = {{Cerebral amyloid angiopathy: a narrative review}},
  journal = {Frontiers in aging neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1632252},
  pmid    = {41035821},
  url     = {https://doi.org/10.3389/fnagi.2025.1632252}
}

@article{shukla2024-38942541,
  author  = {Shukla, Halak and John, Diana and Banerjee, Shuvomoy and Tiwari, Anand Krishna},
  title   = {{Drug repurposing for neurodegenerative diseases}},
  journal = {Progress in molecular biology and translational science},
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  title   = {{Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis}},
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  title   = {{Liraglutide Protects Against Brain Amyloid-β 1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation}},
  journal = {International journal of molecular sciences},
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  title   = {{The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease}},
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  year    = {2020},
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  title   = {{The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice}},
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@article{taheri2020-32738903,
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  title   = {{Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications}},
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@article{panza2023-37620094,
  author  = {Panza, Francesco and Solfrizzi, Vincenzo and Daniele, Antonio and Lozupone, Madia},
  title   = {{Passive tau-based immunotherapy for tauopathies}},
  journal = {Handbook of clinical neurology},
  year    = {2023},
  doi     = {10.1016/b978-0-323-98817-9.00029-6},
  pmid    = {37620094},
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}

@article{luciani2023-37122097,
  author  = {Luciani, Marco and Montalbano, Mauro and Troncone, Luca and Bacchin, Camilla and Uchida, Keita and Daniele, Gianlorenzo and Wolf, Bethany Jacobs and Butler, Helen M and others},
  title   = {{Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy}},
  journal = {European heart journal},
  year    = {2023},
  doi     = {10.1093/eurheartj/ehad205},
  pmid    = {37122097},
  url     = {https://doi.org/10.1093/eurheartj/ehad205}
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@article{weber2023-37666109,
  author  = {Weber, Patrick and Mészáros, Zuzana and Bojarová, Pavla and Ebner, Manuel and Fischer, Roland and Křen, Vladimír and Kulik, Natalia and Müller, Philipp and others},
  title   = {{Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase}},
  journal = {Bioorganic chemistry},
  year    = {2023},
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  pmid    = {37666109},
  url     = {https://doi.org/10.1016/j.bioorg.2023.106819}
}

@article{zhu2021-33999598,
  author  = {Zhu, Lin and Xu, Linlin and Wu, Xiaohui and Deng, Fei and Ma, Rujiang and Liu, Yang and Huang, Fan and Shi, Linqi},
  title   = {{Tau-Targeted Multifunctional Nanoinhibitor for Alzheimer's Disease}},
  journal = {ACS applied materials \& interfaces},
  year    = {2021},
  doi     = {10.1021/acsami.1c00257},
  pmid    = {33999598},
  url     = {https://doi.org/10.1021/acsami.1c00257}
}

@article{panza2023-37405389,
  author  = {Panza, Francesco and Dibello, Vittorio and Sardone, Rodolfo and Castellana, Fabio and Zupo, Roberta and Lampignano, Luisa and Bortone, Ilaria and Stallone, Roberta and others},
  title   = {{Clinical development of passive tau-based immunotherapeutics for treating primary and secondary tauopathies}},
  journal = {Expert opinion on investigational drugs},
  year    = {2023},
  doi     = {10.1080/13543784.2023.2233892},
  pmid    = {37405389},
  url     = {https://doi.org/10.1080/13543784.2023.2233892}
}

@article{self2022-35653415,
  author  = {Self, Wade and Awwad, Khader and Savaryn, John Paul and Schulz, Michael},
  title   = {{An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS}},
  journal = {PloS one},
  year    = {2022},
  doi     = {10.1371/journal.pone.0269157},
  pmid    = {35653415},
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}

@article{koh2021-34884940,
  author  = {Koh, Han Seok and Lee, SangJoon and Lee, Hyo Jin and Min, Jae-Woong and Iwatsubo, Takeshi and Teunissen, Charlotte E and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222313136},
  pmid    = {34884940},
  url     = {https://doi.org/10.3390/ijms222313136}
}

@article{martins2023-38074413,
  author  = {Martins, Dina Rodrigues and Sha, Fern and Van der Elst, Wim and Shih, Pei-Yu and Devoght, Jens and Van Kolen, Kristof and Mercken, Marc and Van Broeck, Bianca and others},
  title   = {{Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies}},
  journal = {Molecular therapy. Methods \& clinical development},
  year    = {2023},
  doi     = {10.1016/j.omtm.2023.101158},
  pmid    = {38074413},
  url     = {https://doi.org/10.1016/j.omtm.2023.101158}
}

@article{oberrauch2021-33524848,
  author  = {Oberrauch, Sara and Metha, Jeremy A and Brian, Maddison L and Barnes, Samuel A and Featherby, Travis J and Lawrence, Andrew J and Hoyer, Daniel and Murawski, Carsten and others},
  title   = {{Reward motivation and cognitive flexibility in tau null-mutation mice}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2020.12.017},
  pmid    = {33524848},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2020.12.017}
}

@article{karimi2022-36410182,
  author  = {Karimi, Nastaran and Çatak, Feyza Bayram and Arslan, Ebru and Saghazadeh, Amene and Rezaei, Nima},
  title   = {{Tau immunotherapy in Alzheimer's disease and progressive supranuclear palsy}},
  journal = {International immunopharmacology},
  year    = {2022},
  doi     = {10.1016/j.intimp.2022.109445},
  pmid    = {36410182},
  url     = {https://doi.org/10.1016/j.intimp.2022.109445}
}

@article{gao2023-37418213,
  author  = {Gao, Shudan and Wang, Yun and Ma, Tao and Zhang, Junying},
  title   = {{The Late Stage of Abnormal Aging: Dementia}},
  journal = {Advances in experimental medicine and biology},
  year    = {2023},
  doi     = {10.1007/978-981-99-1627-6_12},
  pmid    = {37418213},
  url     = {https://doi.org/10.1007/978-981-99-1627-6_12}
}

@article{ingham2021-34009955,
  author  = {Ingham, David J and Blankenfeld, Bryce R and Chacko, Shibin and Perera, Chamani and Oakley, Berl R and Gamblin, Truman Christopher},
  title   = {{Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition}},
  journal = {Biochemistry},
  year    = {2021},
  doi     = {10.1021/acs.biochem.1c00111},
  pmid    = {34009955},
  url     = {https://doi.org/10.1021/acs.biochem.1c00111}
}

@article{morello2023-37759477,
  author  = {Morello, Giovanna and Guarnaccia, Maria and La Cognata, Valentina and Latina, Valentina and Calissano, Pietro and Amadoro, Giuseppina and Cavallaro, Sebastiano},
  title   = {{Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment}},
  journal = {Cells},
  year    = {2023},
  doi     = {10.3390/cells12182254},
  pmid    = {37759477},
  url     = {https://doi.org/10.3390/cells12182254}
}

@article{alshamrani2023-37366656,
  author  = {Alshamrani, Meshal},
  title   = {{Recent Trends in Active and Passive Immunotherapies of Alzheimer's Disease}},
  journal = {Antibodies (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/antib12020041},
  pmid    = {37366656},
  url     = {https://doi.org/10.3390/antib12020041}
}

@article{brown2022-36517890,
  author  = {Brown, Jennifer L and Hart, Damyan W and Boyle, Gabriel E and Brown, Taylor G and LaCroix, Michael and Baraibar, Andrés M and Pelzel, Ross and Kim, Minwoo and others},
  title   = {{SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex}},
  journal = {Acta neuropathologica communications},
  year    = {2022},
  doi     = {10.1186/s40478-022-01480-y},
  pmid    = {36517890},
  url     = {https://doi.org/10.1186/s40478-022-01480-y}
}

@article{levy2022-36160048,
  author  = {Levy, Simon A and Zuniga, Gabrielle and Gonzalez, Elias M and Butler, David and Temple, Sally and Frost, Bess},
  title   = {{TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy}},
  journal = {Cell reports methods},
  year    = {2022},
  doi     = {10.1016/j.crmeth.2022.100292},
  pmid    = {36160048},
  url     = {https://doi.org/10.1016/j.crmeth.2022.100292}
}

@article{alipour2022-36087426,
  author  = {Alipour, Masoume and Tebianian, Majid and Tofigh, Nahid and Taheri, Reyhaneh Sadat and Mousavi, Sayed Alireza and Naseri, Asal and Ahmadi, Amin and Munawar, Nayla and others},
  title   = {{Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models}},
  journal = {Neuropeptides},
  year    = {2022},
  doi     = {10.1016/j.npep.2022.102285},
  pmid    = {36087426},
  url     = {https://doi.org/10.1016/j.npep.2022.102285}
}

@article{liu2023-36621732,
  author  = {Liu, Xin and She, Weiyi and Sung, Herman H-Y and Williams, Ian D and Qian, Peiyuan},
  title   = {{Tau-aggregation inhibitors derived from Streptomyces tendae MCCC 1A01534 protect HT22 cells against okadaic acid-induced damage}},
  journal = {International journal of biological macromolecules},
  year    = {2023},
  doi     = {10.1016/j.ijbiomac.2023.123170},
  pmid    = {36621732},
  url     = {https://doi.org/10.1016/j.ijbiomac.2023.123170}
}

@article{vagenknecht2022-35128565,
  author  = {Vagenknecht, Patrick and Luzgin, Artur and Ono, Maiko and Ji, Bin and Higuchi, Makoto and Noain, Daniela and Maschio, Cinzia A and Sobek, Jens and others},
  title   = {{Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2022},
  doi     = {10.1007/s00259-022-05708-w},
  pmid    = {35128565},
  url     = {https://doi.org/10.1007/s00259-022-05708-w}
}

@article{hill2021-34737403,
  author  = {Hill, Emily and Karikari, Thomas K and Lantero-Rodriguez, Juan and Zetterberg, Henrik and Blennow, Kaj and Richardson, Magnus J and Wall, Mark J},
  title   = {{Truncating tau reveals different pathophysiological actions of oligomers in single neurons}},
  journal = {Communications biology},
  year    = {2021},
  doi     = {10.1038/s42003-021-02791-x},
  pmid    = {34737403},
  url     = {https://doi.org/10.1038/s42003-021-02791-x}
}

@article{li2023-36717015,
  author  = {Li, Longfei and Miao, Jin and Jiang, Yanli and Dai, Chun-Ling and Iqbal, Khalid and Liu, Fei and Chu, Dandan},
  title   = {{Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice}},
  journal = {Experimental neurology},
  year    = {2023},
  doi     = {10.1016/j.expneurol.2023.114337},
  pmid    = {36717015},
  url     = {https://doi.org/10.1016/j.expneurol.2023.114337}
}

@article{lee2023-36989942,
  author  = {Lee, Tae Suk and Park, Eun Ji and Choi, Minkyu and Oh, Hyun Seok and An, Yejin and Kim, Taehyung and Kim, Tae Hwan and Shin, Beom Soo and others},
  title   = {{Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies in rats}},
  journal = {Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year    = {2023},
  doi     = {10.1016/j.jchromb.2023.123688},
  pmid    = {36989942},
  url     = {https://doi.org/10.1016/j.jchromb.2023.123688}
}

@article{dizchaves2022-35180937,
  author  = {Diz-Chaves, Yolanda and Herrera-Pérez, Salvador and González-Matías, Lucas C and Mallo, Federico},
  title   = {{Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus}},
  journal = {Vitamins and hormones},
  year    = {2022},
  doi     = {10.1016/bs.vh.2021.12.005},
  pmid    = {35180937},
  url     = {https://doi.org/10.1016/bs.vh.2021.12.005}
}

@article{begic2021-34479819,
  author  = {Begic, Edin and Causevic, Mirsada},
  title   = {{Glucagon-Like Peptide-1 Receptor Agonists and Brain Vascular Function}},
  journal = {Heart, lung \& circulation},
  year    = {2021},
  doi     = {10.1016/j.hlc.2021.07.024},
  pmid    = {34479819},
  url     = {https://doi.org/10.1016/j.hlc.2021.07.024}
}

@article{vargassoria2021-34118986,
  author  = {Vargas-Soria, Maria and Carranza-Naval, Maria Jose and Del Marco, Angel and Garcia-Alloza, Monica},
  title   = {{Role of liraglutide in Alzheimer's disease pathology}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00853-0},
  pmid    = {34118986},
  url     = {https://doi.org/10.1186/s13195-021-00853-0}
}

@article{viljoen2023-36740965,
  author  = {Viljoen, Adie and Bain, Stephen C},
  title   = {{Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond}},
  journal = {Endocrinology and metabolism (Seoul, Korea)},
  year    = {2023},
  doi     = {10.3803/enm.2022.1642},
  pmid    = {36740965},
  url     = {https://doi.org/10.3803/enm.2022.1642}
}

@article{qi2022-35985417,
  author  = {Qi, Liqin and Gao, Ruonan and Chen, Zhou and Lin, Donghai and Liu, Zhiqing and Wang, Linxi and Lin, Lijing and Liu, Xiaoying and others},
  title   = {{Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells}},
  journal = {Neurotoxicology},
  year    = {2022},
  doi     = {10.1016/j.neuro.2022.08.007},
  pmid    = {35985417},
  url     = {https://doi.org/10.1016/j.neuro.2022.08.007}
}

@article{chen2023-36470445,
  author  = {Chen, Shang-Der and Chuang, Yao-Chung and Lin, Tsu-Kung and Yang, Jenq-Lin},
  title   = {{Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases}},
  journal = {European journal of pharmacology},
  year    = {2023},
  doi     = {10.1016/j.ejphar.2022.175439},
  pmid    = {36470445},
  url     = {https://doi.org/10.1016/j.ejphar.2022.175439}
}

@article{cummings2022-35128745,
  author  = {Cummings, Jeffrey and Ortiz, Andrew and Castellino, Janelle and Kinney, Jefferson},
  title   = {{Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease}},
  journal = {The European journal of neuroscience},
  year    = {2022},
  doi     = {10.1111/ejn.15619},
  pmid    = {35128745},
  url     = {https://doi.org/10.1111/ejn.15619}
}

@article{li2021-34552561,
  author  = {Li, Qiu-Xuan and Gao, Han and Guo, Yue-Xin and Wang, Bo-Ya and Hua, Rong-Xuan and Gao, Lei and Shang, Hong-Wei and Lu, Xin and others},
  title   = {{GLP-1 and Underlying Beneficial Actions in Alzheimer's Disease, Hypertension, and NASH}},
  journal = {Frontiers in endocrinology},
  year    = {2021},
  doi     = {10.3389/fendo.2021.721198},
  pmid    = {34552561},
  url     = {https://doi.org/10.3389/fendo.2021.721198}
}

@article{deden2021-34942949,
  author  = {Deden, Laura N and Booij, Jan and Grandjean, Joanes and Homberg, Judith R and Hazebroek, Eric J and Gotthardt, Martin and Boss, Marti},
  title   = {{Brain Imaging of the GLP-1 Receptor in Obesity Using 68Ga-NODAGA-Exendin-4 PET}},
  journal = {Brain sciences},
  year    = {2021},
  doi     = {10.3390/brainsci11121647},
  pmid    = {34942949},
  url     = {https://doi.org/10.3390/brainsci11121647}
}

@article{kreiner2023-37191234,
  author  = {Kreiner, Frederik Flindt and von Scholten, Bernt Johan and Kurtzhals, Peter and Gough, Stephen Charles Langford},
  title   = {{Glucagon-like peptide-1 receptor agonists to expand the healthy lifespan: Current and future potentials}},
  journal = {Aging cell},
  year    = {2023},
  doi     = {10.1111/acel.13818},
  pmid    = {37191234},
  url     = {https://doi.org/10.1111/acel.13818}
}

@article{mouhammad2022-35264926,
  author  = {Mouhammad, Zaynab Ahmad and Vohra, Rupali and Horwitz, Anna and Thein, Anna-Sophie and Rovelt, Jens and Cvenkel, Barbara and Williams, Pete A and Azuara-Blanco, Augusto and others},
  title   = {{Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.824054},
  pmid    = {35264926},
  url     = {https://doi.org/10.3389/fnins.2022.824054}
}

@article{liu2021-34676939,
  author  = {Liu, Xiao-Yu and Zhang, Ni and Zhang, Sheng-Xiao and Xu, Ping},
  title   = {{Potential new therapeutic target for Alzheimer's disease: Glucagon-like peptide-1}},
  journal = {The European journal of neuroscience},
  year    = {2021},
  doi     = {10.1111/ejn.15502},
  pmid    = {34676939},
  url     = {https://doi.org/10.1111/ejn.15502}
}

@article{dizchaves2022-36076972,
  author  = {Diz-Chaves, Yolanda and Mastoor, Zainab and Spuch, Carlos and González-Matías, Lucas C and Mallo, Federico},
  title   = {{Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23179583},
  pmid    = {36076972},
  url     = {https://doi.org/10.3390/ijms23179583}
}

@article{lagerupprecht2022-35510183,
  author  = {Lage-Rupprecht, Vanessa and Schultz, Bruce and Dick, Justus and Namysl, Marcin and Zaliani, Andrea and Gebel, Stephan and Pless, Ole and Reinshagen, Jeanette and others},
  title   = {{A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism}},
  journal = {Patterns (New York, N.Y.)},
  year    = {2022},
  doi     = {10.1016/j.patter.2021.100433},
  pmid    = {35510183},
  url     = {https://doi.org/10.1016/j.patter.2021.100433}
}

@article{goodarzi2023-37335453,
  author  = {Goodarzi, Golnaz and Tehrani, Sadra Samavarchi and Fana, Saeed Ebrahimi and Moradi-Sardareh, Hemen and Panahi, Ghodratollah and Maniati, Mahmood and Meshkani, Reza},
  title   = {{Crosstalk between Alzheimer's disease and diabetes: a focus on anti-diabetic drugs}},
  journal = {Metabolic brain disease},
  year    = {2023},
  doi     = {10.1007/s11011-023-01225-3},
  pmid    = {37335453},
  url     = {https://doi.org/10.1007/s11011-023-01225-3}
}

@article{neha2023-36529440,
  author  = {Neha and Parvez, Suhel},
  title   = {{Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer's disease}},
  journal = {Ageing research reviews},
  year    = {2023},
  doi     = {10.1016/j.arr.2022.101815},
  pmid    = {36529440},
  url     = {https://doi.org/10.1016/j.arr.2022.101815}
}

@article{liu2022-35395400,
  author  = {Liu, Wei and Wang, Gang and Wang, Zhiwen and Wang, Guan and Huang, Jianping and Liu, Bo},
  title   = {{Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases}},
  journal = {Drug discovery today},
  year    = {2022},
  doi     = {10.1016/j.drudis.2022.04.003},
  pmid    = {35395400},
  url     = {https://doi.org/10.1016/j.drudis.2022.04.003}
}

@article{parolo2023-36604493,
  author  = {Parolo, Silvia and Mariotti, Federica and Bora, Pranami and Carboni, Lucia and Domenici, Enrico},
  title   = {{Single-cell-led drug repurposing for Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2023},
  doi     = {10.1038/s41598-023-27420-x},
  pmid    = {36604493},
  url     = {https://doi.org/10.1038/s41598-023-27420-x}
}

@article{feng2021-34163481,
  author  = {Feng, Xiaojun and Chen, Wenxu and Ni, Xiayun and Little, Peter J and Xu, Suowen and Tang, Liqin and Weng, Jianping},
  title   = {{Metformin, Macrophage Dysfunction and Atherosclerosis}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.682853},
  pmid    = {34163481},
  url     = {https://doi.org/10.3389/fimmu.2021.682853}
}

@article{mohle2023-37508364,
  author  = {Möhle, Luisa and Stefan, Katja and Bascuñana, Pablo and Brackhan, Mirjam and Brüning, Thomas and Eiriz, Ivan and El Menuawy, Ahmed and van Genderen, Sylvie and others},
  title   = {{ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer's Disease}},
  journal = {Biology},
  year    = {2023},
  doi     = {10.3390/biology12070932},
  pmid    = {37508364},
  url     = {https://doi.org/10.3390/biology12070932}
}

@article{mansour2021-34139302,
  author  = {Mansour, Heba M and Fawzy, Hala M and El-Khatib, Aiman S and Khattab, Mahmoud M},
  title   = {{Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer's Disease: Current Perspectives and Challenging Prospects}},
  journal = {Neuroscience},
  year    = {2021},
  doi     = {10.1016/j.neuroscience.2021.06.013},
  pmid    = {34139302},
  url     = {https://doi.org/10.1016/j.neuroscience.2021.06.013}
}

@article{khezri2022-35134385,
  author  = {Khezri, Mohammad Rafi and Yousefi, Keyvan and Mahboubi, Negin and Hodaei, Darya and Ghasemnejad-Berenji, Morteza},
  title   = {{Metformin in Alzheimer's disease: An overview of potential mechanisms, preclinical and clinical findings}},
  journal = {Biochemical pharmacology},
  year    = {2022},
  doi     = {10.1016/j.bcp.2022.114945},
  pmid    = {35134385},
  url     = {https://doi.org/10.1016/j.bcp.2022.114945}
}

@article{jimenez2023-36677633,
  author  = {Jiménez, Elvia Mera and Żołek, Teresa and Perez, Paola Gabriela Hernández and Ruvalcaba, Rene Miranda and Nicolás-Vázquez, María Inés and Hernández-Rodríguez, Maricarmen},
  title   = {{Drug Repurposing to Inhibit Histamine N-Methyl Transferase}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/molecules28020576},
  pmid    = {36677633},
  url     = {https://doi.org/10.3390/molecules28020576}
}

@article{nabirotchkin2022-35811522,
  author  = {Nabirotchkin, Serguei and Bouaziz, Jan and Glibert, Fabrice and Mandel, Jonas and Foucquier, Julie and Hajj, Rodolphe and Callizot, Noëlle and Cholet, Nathalie and others},
  title   = {{Combinational Drug Repurposing from Genetic Networks Applied to Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220120},
  pmid    = {35811522},
  url     = {https://doi.org/10.3233/jad-220120}
}

@article{savva2022-35386099,
  author  = {Savva, Kyriaki and Zachariou, Margarita and Bourdakou, Marilena M and Dietis, Nikolas and Spyrou, George M},
  title   = {{Network-based stage-specific drug repurposing for Alzheimer's disease}},
  journal = {Computational and structural biotechnology journal},
  year    = {2022},
  doi     = {10.1016/j.csbj.2022.03.013},
  pmid    = {35386099},
  url     = {https://doi.org/10.1016/j.csbj.2022.03.013}
}

@article{nam2021-34482237,
  author  = {Nam, Geewoo and Suh, Jong-Min and Yi, Yelim and Lim, Mi Hee},
  title   = {{Drug repurposing: small molecules against Cu(II)-amyloid-β and free radicals}},
  journal = {Journal of inorganic biochemistry},
  year    = {2021},
  doi     = {10.1016/j.jinorgbio.2021.111592},
  pmid    = {34482237},
  url     = {https://doi.org/10.1016/j.jinorgbio.2021.111592}
}

@article{urbina2021-34274565,
  author  = {Urbina, Fabio and Puhl, Ana C and Ekins, Sean},
  title   = {{Recent advances in drug repurposing using machine learning}},
  journal = {Current opinion in chemical biology},
  year    = {2021},
  doi     = {10.1016/j.cbpa.2021.06.001},
  pmid    = {34274565},
  url     = {https://doi.org/10.1016/j.cbpa.2021.06.001}
}

@article{zhao2023-36422837,
  author  = {Zhao, Shuai and Fan, Ziqi and Zhang, Xinyi and Li, Zheyu and Shen, Ting and Li, Kaicheng and Yan, Yaping and Yuan, Yunfeng and others},
  title   = {{Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2023},
  doi     = {10.1007/s13311-022-01316-6},
  pmid    = {36422837},
  url     = {https://doi.org/10.1007/s13311-022-01316-6}
}

@article{cai2021-34378011,
  author  = {Cai, Lijun and Lu, Changcheng and Xu, Junlin and Meng, Yajie and Wang, Peng and Fu, Xiangzheng and Zeng, Xiangxiang and Su, Yansen},
  title   = {{Drug repositioning based on the heterogeneous information fusion graph convolutional network}},
  journal = {Briefings in bioinformatics},
  year    = {2021},
  doi     = {10.1093/bib/bbab319},
  pmid    = {34378011},
  url     = {https://doi.org/10.1093/bib/bbab319}
}

@article{pope2021-33899637,
  author  = {Pope, Evans D and Cordes, Laura and Shi, Jiong and Mari, Zoltan and Decourt, Boris and Sabbagh, Marwan Noel},
  title   = {{Dementia with Lewy bodies: emerging drug targets and therapeutics}},
  journal = {Expert opinion on investigational drugs},
  year    = {2021},
  doi     = {10.1080/13543784.2021.1916913},
  pmid    = {33899637},
  url     = {https://doi.org/10.1080/13543784.2021.1916913}
}

@article{hamano2021-34299093,
  author  = {Hamano, Tadanori and Enomoto, Soichi and Shirafuji, Norimichi and Ikawa, Masamichi and Yamamura, Osamu and Yen, Shu-Hui and Nakamoto, Yasunari},
  title   = {{Autophagy and Tau Protein}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22147475},
  pmid    = {34299093},
  url     = {https://doi.org/10.3390/ijms22147475}
}

@article{rybakowski2022-35364656,
  author  = {Rybakowski, Janusz K},
  title   = {{Antiviral, immunomodulatory, and neuroprotective effect of lithium}},
  journal = {Journal of integrative neuroscience},
  year    = {2022},
  doi     = {10.31083/j.jin2102068},
  pmid    = {35364656},
  url     = {https://doi.org/10.31083/j.jin2102068}
}

@article{naseri2023-36474458,
  author  = {Naseri, Amirreza and Sanaie, Sarvin and Hamzehzadeh, Sina and Seyedi-Sahebari, Sepideh and Hosseini, Mohammad-Salar and Gholipour-Khalili, Elnaz and Rezazadeh-Gavgani, Ehsan and Majidazar, Reza and others},
  title   = {{Metformin: new applications for an old drug}},
  journal = {Journal of basic and clinical physiology and pharmacology},
  year    = {2023},
  doi     = {10.1515/jbcpp-2022-0252},
  pmid    = {36474458},
  url     = {https://doi.org/10.1515/jbcpp-2022-0252}
}

@article{byrns2021-33476559,
  author  = {Byrns, China N and Bonini, Nancy M},
  title   = {{An Integrated Multi-omics Approach Identifies Therapeutic Potential for ATP6V1A in Late Onset Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2020.12.015},
  pmid    = {33476559},
  url     = {https://doi.org/10.1016/j.neuron.2020.12.015}
}

@article{zhang2021-34432352,
  author  = {Zhang, Yali and Fan, Xing and Su, Zhangyao and Yuan, Tianli and Yin, Haimeng and Gu, Haohao and Zuo, Yue and Chen, Shiyin and others},
  title   = {{Pretreatment with metformin prevents microcystin-LR-induced tau hyperphosphorylation via mTOR-dependent PP2A and GSK-3β activation}},
  journal = {Environmental toxicology},
  year    = {2021},
  doi     = {10.1002/tox.23354},
  pmid    = {34432352},
  url     = {https://doi.org/10.1002/tox.23354}
}

@article{liao2021-35153733,
  author  = {Liao, Wang and Xu, Jiaxin and Li, Bo and Ruan, Yuting and Li, Tian and Liu, Jun},
  title   = {{Deciphering the Roles of Metformin in Alzheimer's Disease: A Snapshot}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.728315},
  pmid    = {35153733},
  url     = {https://doi.org/10.3389/fphar.2021.728315}
}

@article{kakoti2022-36263141,
  author  = {Kakoti, Bibhuti Bhusan and Bezbaruah, Rajashri and Ahmed, Nasima},
  title   = {{Therapeutic drug repositioning with special emphasis on neurodegenerative diseases: Threats and issues}},
  journal = {Frontiers in pharmacology},
  year    = {2022},
  doi     = {10.3389/fphar.2022.1007315},
  pmid    = {36263141},
  url     = {https://doi.org/10.3389/fphar.2022.1007315}
}

@article{chen2022-35401820,
  author  = {Chen, Sheng and Gan, Donghao and Lin, Sixiong and Zhong, Yiming and Chen, Mingjue and Zou, Xuenong and Shao, Zengwu and Xiao, Guozhi},
  title   = {{Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms}},
  journal = {Theranostics},
  year    = {2022},
  doi     = {10.7150/thno.71360},
  pmid    = {35401820},
  url     = {https://doi.org/10.7150/thno.71360}
}

@article{eshraghi2022-35304223,
  author  = {Eshraghi, Mehdi and Ahmadi, Mazaher and Afshar, Saeid and Lorzadeh, Shahrokh and Adlimoghaddam, Aida and Jalal, Nahid Rezvani and West, Ryan and Dastghaib, Sanaz and others},
  title   = {{Enhancing autophagy in Alzheimer's disease through drug repositioning}},
  journal = {Pharmacology \& therapeutics},
  year    = {2022},
  doi     = {10.1016/j.pharmthera.2022.108171},
  pmid    = {35304223},
  url     = {https://doi.org/10.1016/j.pharmthera.2022.108171}
}

@article{bayraktar2023-37210557,
  author  = {Bayraktar, Abdulahad and Li, Xiangyu and Kim, Woonghee and Zhang, Cheng and Turkez, Hasan and Shoaie, Saeed and Mardinoglu, Adil},
  title   = {{Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients}},
  journal = {Journal of translational medicine},
  year    = {2023},
  doi     = {10.1186/s12967-023-04192-6},
  pmid    = {37210557},
  url     = {https://doi.org/10.1186/s12967-023-04192-6}
}

@article{ashraf2022-35889524,
  author  = {Ashraf, Ghulam Md and DasGupta, Debarati and Alam, Mohammad Zubair and Baeesa, Saleh S and Alghamdi, Badrah S and Anwar, Firoz and Alqurashi, Thamer M A and Sharaf, Sharaf E and others},
  title   = {{Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2022},
  doi     = {10.3390/molecules27144652},
  pmid    = {35889524},
  url     = {https://doi.org/10.3390/molecules27144652}
}

@article{agarwal2023-35733313,
  author  = {Agarwal, Kritie and Katare, Deepshikha Pande and Jakhmola-Mani, Ruchi},
  title   = {{Foresee Novel Targets for Alzheimer's Disease by Investigating Repurposed Drugs}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2023},
  doi     = {10.2174/1871527321666220622162622},
  pmid    = {35733313},
  url     = {https://doi.org/10.2174/1871527321666220622162622}
}

@article{sanati2022-34999113,
  author  = {Sanati, Mehdi and Aminyavari, Samaneh and Afshari, Amir R and Sahebkar, Amirhossein},
  title   = {{Mechanistic insight into the role of metformin in Alzheimer's disease}},
  journal = {Life sciences},
  year    = {2022},
  doi     = {10.1016/j.lfs.2021.120299},
  pmid    = {34999113},
  url     = {https://doi.org/10.1016/j.lfs.2021.120299}
}

@article{haussmann2021-34119602,
  author  = {Haussmann, Robert and Noppes, Felix and Brandt, Moritz D and Bauer, Michael and Donix, Markus},
  title   = {{Lithium: A therapeutic option in Alzheimer's disease and its prodromal stages?}},
  journal = {Neuroscience letters},
  year    = {2021},
  doi     = {10.1016/j.neulet.2021.136044},
  pmid    = {34119602},
  url     = {https://doi.org/10.1016/j.neulet.2021.136044}
}

@article{oliveira2021-34283253,
  author  = {Oliveira, Wilma Helena and Braga, Clarissa Figueiredo and Lós, Deniele Bezerra and Araújo, Shyrlene Meiry Rocha and França, MariaEduarda Rocha and Duarte-Silva, Eduardo and Rodrigues, Gabriel Barros and Rocha, Sura Wanessa Santos and others},
  title   = {{Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice}},
  journal = {Experimental brain research},
  year    = {2021},
  doi     = {10.1007/s00221-021-06176-8},
  pmid    = {34283253},
  url     = {https://doi.org/10.1007/s00221-021-06176-8}
}

@article{alkuraishy2023-36849855,
  author  = {Al-Kuraishy, Hayder M and Al-Gareeb, Ali I and Saad, Hebatallah M and Batiha, Gaber El-Saber},
  title   = {{Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects}},
  journal = {Inflammopharmacology},
  year    = {2023},
  doi     = {10.1007/s10787-023-01163-7},
  pmid    = {36849855},
  url     = {https://doi.org/10.1007/s10787-023-01163-7}
}

@article{muronaga2022-36073313,
  author  = {Muronaga, Masaaki and Terao, Takeshi and Kohno, Kentaro and Hirakawa, Hirofumi and Izumi, Toshihiko and Etoh, Masaki},
  title   = {{Lithium in drinking water and Alzheimer's dementia: Epidemiological Findings from National Data Base of Japan}},
  journal = {Bipolar disorders},
  year    = {2022},
  doi     = {10.1111/bdi.13257},
  pmid    = {36073313},
  url     = {https://doi.org/10.1111/bdi.13257}
}

@article{zhu2022-35765655,
  author  = {Zhu, Sha and Bai, Qifeng and Li, Lanqing and Xu, Tingyang},
  title   = {{Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents}},
  journal = {Computational and structural biotechnology journal},
  year    = {2022},
  doi     = {10.1016/j.csbj.2022.05.057},
  pmid    = {35765655},
  url     = {https://doi.org/10.1016/j.csbj.2022.05.057}
}

@article{chen2021-34717542,
  author  = {Chen, Peng and Bao, Tianjiazhi and Yu, Xiaosheng and Liu, Zhongtu},
  title   = {{A drug repositioning algorithm based on a deep autoencoder and adaptive fusion}},
  journal = {BMC bioinformatics},
  year    = {2021},
  doi     = {10.1186/s12859-021-04406-y},
  pmid    = {34717542},
  url     = {https://doi.org/10.1186/s12859-021-04406-y}
}

@article{benjanuwattra2020-32621957,
  author  = {Benjanuwattra, Juthipong and Apaijai, Nattayaporn and Chunchai, Titikorn and Kerdphoo, Sasiwan and Jaiwongkam, Thidarat and Arunsak, Bussarin and Wongsuchai, Supawit and Chattipakorn, Nipon and others},
  title   = {{Metformin preferentially provides neuroprotection following cardiac ischemia/reperfusion in non-diabetic rats}},
  journal = {Biochimica et biophysica acta. Molecular basis of disease},
  year    = {2020},
  doi     = {10.1016/j.bbadis.2020.165893},
  pmid    = {32621957},
  url     = {https://doi.org/10.1016/j.bbadis.2020.165893}
}

@article{makeeva2023-38069121,
  author  = {Makeeva, Vladlena S and Dyrkheeva, Nadezhda S and Lavrik, Olga I and Zakian, Suren M and Malakhova, Anastasia A},
  title   = {{Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms242316798},
  pmid    = {38069121},
  url     = {https://doi.org/10.3390/ijms242316798}
}

@article{matuszewski2026-fe439787,
  author  = {Matuszewski, W. and Wołos-Kłosowicz, K. and Włodarczyk, P. and Waśniewska, P. and Modzelewski, R. and Górny, J. M. and Szklarz, M. and Juranek, J.},
  title   = {{Beyond Glycemic Control: GLP-1RA–Based Therapies and Emerging Targets Beyond the Metabolic Axis}},
  journal = {Journal of clinical medicine},
  year    = {2026},
  doi     = {10.20944/preprints202602.0277.v1},
  url     = {https://doi.org/10.20944/preprints202602.0277.v1}
}

@article{jantrapirom2020-32138327,
  author  = {Jantrapirom, Salinee and Nimlamool, Wutigri and Chattipakorn, Nipon and Chattipakorn, Siriporn Chaisin and Temviriyanukul, Piya and Inthachat, Woorawee and Govitrapong, Piyarat and Potikanond, Saranyapin},
  title   = {{Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity}},
  journal = {International Journal of Molecular Sciences},
  year    = {2020},
  doi     = {10.3390/ijms21051725},
  pmid    = {32138327},
  url     = {https://doi.org/10.3390/ijms21051725}
}

@article{panagaki2017-29170452,
  author  = {Panagaki, Theodora and Michael, Maria and Hölscher, Christian},
  title   = {{Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells}},
  journal = {Scientific Reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-16488-x},
  pmid    = {29170452},
  url     = {https://doi.org/10.1038/s41598-017-16488-x}
}

@article{elsahar2020-33125461,
  author  = {El-Sahar, Ayman E. and Shiha, Nesma A. and El Sayed, Nesrine S. and Ahmed, Lamiaa A.},
  title   = {{Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways}},
  journal = {The International Journal of Neuropsychopharmacology},
  year    = {2020},
  doi     = {10.1093/ijnp/pyaa078},
  pmid    = {33125461},
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