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% Source: https://alzhub.org/research?category=down_syndrome
% 500 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{robertson2015-26076844,
  author  = {Robertson, J. and Hatton, C. and Emerson, E. and Baines, S.},
  title   = {{Prevalence of epilepsy among people with intellectual disabilities: A systematic review}},
  journal = {Seizure},
  year    = {2015},
  doi     = {10.1016/j.seizure.2015.03.016},
  pmid    = {26076844},
  url     = {https://doi.org/10.1016/j.seizure.2015.03.016}
}

@article{handen2020-32775597,
  author  = {Handen, B. L. and Lott, I. T. and Christian, B. T. and Schupf, N. and OBryant, S. and Mapstone, M. and Fagan, A. M. and Lee, J. H. and others},
  title   = {{The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2020},
  doi     = {10.1002/dad2.12065},
  pmid    = {32775597},
  url     = {https://doi.org/10.1002/dad2.12065}
}

@article{videla2025-40528282,
  author  = {Videla, L. and Benejam, B. and Barroeta, I. and Fernandez, S. and Altuna, M. and Arranz, J. and Í, Rodríguez-Baz and Arriola-Infante, J. E. and others},
  title   = {{The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70259},
  pmid    = {40528282},
  url     = {https://doi.org/10.1002/alz.70259}
}

@article{santoro2026-42897209,
  author  = {Santoro, J. D. and Abdel-Latif, S. and Banerjee, A. K. and Mager, H. and Silverman, M. and Kazerooni, L. and Otey, S. T. and Yousuf, M. M. and others},
  title   = {{Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder}},
  journal = {Communications medicine},
  year    = {2026},
  doi     = {10.1038/s43856-026-01921-y},
  pmid    = {42897209},
  url     = {https://doi.org/10.1038/s43856-026-01921-y}
}

@article{videla2022-35930282,
  author  = {Videla, L. and Benejam, B. and Pegueroles, J. and Carmona-Iragui, M. and Padilla, C. and Fernández, S. and Barroeta, I. and Altuna, M. and others},
  title   = {{Longitudinal Clinical and Cognitive Changes Along the Alzheimer Disease Continuum in Down Syndrome}},
  journal = {JAMA network open},
  year    = {2022},
  doi     = {10.1001/jamanetworkopen.2022.25573},
  pmid    = {35930282},
  url     = {https://doi.org/10.1001/jamanetworkopen.2022.25573}
}

@article{rubenstein2024-39312235,
  author  = {Rubenstein, E. and Tewolde, S. and Michals, A. and Weuve, J. and Fortea, J. and Fox, M. P. and Pescador Jimenez, M. and Scott, A. and others},
  title   = {{Alzheimer Dementia Among Individuals With Down Syndrome}},
  journal = {JAMA network open},
  year    = {2024},
  doi     = {10.1001/jamanetworkopen.2024.35018},
  pmid    = {39312235},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.35018}
}

@article{kwetsie2024-38759134,
  author  = {Kwetsie, H. and van Schaijk, M. and Van Der Lee, S. and Maes-Festen, D. and Ten Hoopen, L. W. and van Haelst, M. M. and Coesmans, M. and Van Den Berg, E. and others},
  title   = {{Dementia in Rare Genetic Neurodevelopmental Disorders: A Systematic Literature Review}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000209413},
  pmid    = {38759134},
  url     = {https://doi.org/10.1212/wnl.0000000000209413}
}

@article{mclachlan2024-c829b099,
  author  = {McLachlan, M. and Bettcher, B. and McVea, A. and DiFillipo, A. and Zammit, M. and LeMerise, L. and Rouanet, J. and Price, J. and others},
  title   = {{The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1101/2024.12.04.24318526},
  url     = {https://doi.org/10.1101/2024.12.04.24318526}
}

@article{bayen2018-30032260,
  author  = {Bayen, E. and Possin, K. L. and Chen, Y. and Cleret de Langavant, L. and Yaffe, K.},
  title   = {{Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2018.2210},
  pmid    = {30032260},
  url     = {https://doi.org/10.1001/jamaneurol.2018.2210}
}

@article{lott2019-30733618,
  author  = {Lott, I. T. and Head, E.},
  title   = {{Dementia in Down syndrome: unique insights for Alzheimer disease research}},
  journal = {Nature reviews. Neurology},
  year    = {2019},
  doi     = {10.1038/s41582-018-0132-6},
  pmid    = {30733618},
  url     = {https://doi.org/10.1038/s41582-018-0132-6}
}

@article{mclachlan2025-40189783,
  author  = {McLachlan, M. and Bettcher, B. and McVea, A. and DiFilippo, A. and Zammit, M. and LeMerise, L. and Rouanet, J. and Price, J. and others},
  title   = {{The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70141},
  pmid    = {40189783},
  url     = {https://doi.org/10.1002/alz.70141}
}

@article{cooper2016-27473843,
  author  = {Cooper, S. A. and Ademola, T. and Caslake, M. and Douglas, E. and Evans, J. and Greenlaw, N. and Haig, C. and Hassiotis, A. and others},
  title   = {{Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial}},
  journal = {Trials},
  year    = {2016},
  doi     = {10.1186/s13063-016-1370-9},
  pmid    = {27473843},
  url     = {https://doi.org/10.1186/s13063-016-1370-9}
}

@article{schupf2007-17620492,
  author  = {Schupf, N. and Patel, B. and Pang, D. and Zigman, W. B. and Silverman, W. and Mehta, P. D. and Mayeux, R.},
  title   = {{Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.7.1007},
  pmid    = {17620492},
  url     = {https://doi.org/10.1001/archneur.64.7.1007}
}

@article{wisch2026-41205623,
  author  = {Wisch, J. K. and Jiao, Z. and Kennedy, J. T. and Cohen, A. D. and Schlachetzki, Z. and Petersen, M. and Handen, B. L. and Christian, B. T. and others},
  title   = {{Imaging and plasma biomarkers for pathological accumulation in Down syndrome}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awaf418},
  pmid    = {41205623},
  url     = {https://doi.org/10.1093/brain/awaf418}
}

@article{fortea2020-32593336,
  author  = {Fortea, Juan and Vilaplana, Eduard and Carmona‐Iragui, María and Benejam, Bessy and Videla, Laura and Barroeta, Isabel and Fernández, Susana and Altuna, Miren and Pegueroles, Jordi and Montal, Víctor and Valldeneu, Sílvia and Giménez, Sandra and González‐Ortiz, Sofía and Muñoz, Laia and Estellés, Teresa and Illán‐Gala, Ignacio and Belbin, Olivia and Camacho, Valle and Wilson, Liam Reese and Annus, Tiina and Osorio, Ricardo S. and Videla, Sebastián and Lehmann, Sylvain and Holland, Anthony John and Alcolea, Daniel Andres and Clarimón, Jordi and Zaman, Shahid H. and Blesa, Rafael and Lleó, Alberto},
  title   = {{Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study}},
  journal = {The Lancet},
  year    = {2020},
  doi     = {10.1016/s0140-6736(20)30689-9},
  pmid    = {32593336},
  url     = {https://doi.org/10.1016/s0140-6736(20)30689-9}
}

@article{rowe2006-16480563,
  author  = {Rowe, J. and Lavender, A. and Turk, V.},
  title   = {{Cognitive executive function in Down's syndrome}},
  journal = {The British journal of clinical psychology},
  year    = {2006},
  doi     = {10.1348/014466505x29594},
  pmid    = {16480563},
  url     = {https://doi.org/10.1348/014466505x29594}
}

@article{tanzi1987-2949367,
  author  = {Tanzi, R. E. and Gusella, J. F. and Watkins, P. C. and Bruns, G. A. and St George-Hyslop, P. and Van Keuren, M. L. and Patterson, D. and Pagan, S. and others},
  title   = {{Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus}},
  journal = {Science (New York, N.Y.)},
  year    = {1987},
  doi     = {10.1126/science.2949367},
  pmid    = {2949367},
  url     = {https://doi.org/10.1126/science.2949367}
}

@article{korbel2009-19597142,
  author  = {Korbel, J. O. and Tirosh-Wagner, T. and Urban, A. E. and Chen, X. N. and Kasowski, M. and Dai, L. and Grubert, F. and Erdman, C. and others},
  title   = {{The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0813248106},
  pmid    = {19597142},
  url     = {https://doi.org/10.1073/pnas.0813248106}
}

@article{masters1985-3159021,
  author  = {Masters, C. L. and Simms, G. and Weinman, N. A. and Multhaup, G. and McDonald, B. L. and Beyreuther, K.},
  title   = {{Amyloid plaque core protein in Alzheimer disease and Down syndrome}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1985},
  doi     = {10.1073/pnas.82.12.4245},
  pmid    = {3159021},
  url     = {https://doi.org/10.1073/pnas.82.12.4245}
}

@article{oeckl2022-35340050,
  author  = {Oeckl, P. and Wagemann, O. and Halbgebauer, S. and Anderl-Straub, S. and Nuebling, G. and Prix, C. and Loosli, S. V. and Wlasich, E. and others},
  title   = {{Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181}},
  journal = {Annals of neurology},
  year    = {2022},
  doi     = {10.1002/ana.26360},
  pmid    = {35340050},
  url     = {https://doi.org/10.1002/ana.26360}
}

@article{kac2025-40275833,
  author  = {Kac, P. R. and Alcolea, D. and Montoliu-Gaya, L. and Fernández, S. and Rodriguez, J. L. and Maure, L. and González-Ortiz, F. and Benejam, B. and others},
  title   = {{Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70172},
  pmid    = {40275833},
  url     = {https://doi.org/10.1002/alz.70172}
}

@article{zammit2026-41240365,
  author  = {Zammit, M. D. and Bruzzone, H. and Cody, K. A. and Morse, J. and Wilson, R. and Bettcher, B. T. and McLachlan, M. J. and McVea, A. K. and others},
  title   = {{The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awaf428},
  pmid    = {41240365},
  url     = {https://doi.org/10.1093/brain/awaf428}
}

@article{xicota2024-39500037,
  author  = {Xicota, L. and Dang, L. T. and Lee, A. and Krinsky-McHale, S. and Pang, D. and Melilli, L. and O'Bryant, S. and Henson, R. L. and others},
  title   = {{The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome}},
  journal = {EBioMedicine},
  year    = {2024},
  doi     = {10.1016/j.ebiom.2024.105433},
  pmid    = {39500037},
  url     = {https://doi.org/10.1016/j.ebiom.2024.105433}
}

@article{chung2026-42096659,
  author  = {Chung, P. A. and Fleming, V. L. and Reid, K. J. and Plante, D. T. and Hom, C. L. and Ances, B. M. and Handen, B. L. and Christian, B. T. and others},
  title   = {{Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000214938},
  pmid    = {42096659},
  url     = {https://doi.org/10.1212/wnl.0000000000214938}
}

@article{wisniewski1985-3158266,
  author  = {Wisniewski, K. E. and Wı́sniewski, Henryk M. and Wen, G. Y.},
  title   = {{Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome}},
  journal = {Annals of Neurology},
  year    = {1985},
  doi     = {10.1002/ana.410170310},
  pmid    = {3158266},
  url     = {https://doi.org/10.1002/ana.410170310}
}

@article{santoro2020-31767984,
  author  = {Santoro, S. L. and Cannon, S. and Capone, G. and Franklin, C. and Hart, S. J. and Hobensack, V. and Kishnani, P. S. and Macklin, E. A. and others},
  title   = {{Unexplained regression in Down syndrome: 35 cases from an international Down syndrome database}},
  journal = {Genetics in medicine : official journal of the American College of Medical Genetics},
  year    = {2020},
  doi     = {10.1038/s41436-019-0706-8},
  pmid    = {31767984},
  url     = {https://doi.org/10.1038/s41436-019-0706-8}
}

@article{lanzillotta2024-38705491,
  author  = {Lanzillotta, C. and Baniowska, M. R. and Prestia, F. and Sette, C. and Nalesso, V. and Perluigi, M. and Barone, E. and Duchon, A. and others},
  title   = {{Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model}},
  journal = {Neurobiology of disease},
  year    = {2024},
  doi     = {10.1016/j.nbd.2024.106523},
  pmid    = {38705491},
  url     = {https://doi.org/10.1016/j.nbd.2024.106523}
}

@article{montoliugaya2025-40595720,
  author  = {Montoliu-Gaya, L. and Bian, S. and Dammer, E. B. and Alcolea, D. and Sauer, M. and Martá-Ariza, M. and Ashton, N. J. and Belbin, O. and others},
  title   = {{Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-61054-z},
  pmid    = {40595720},
  url     = {https://doi.org/10.1038/s41467-025-61054-z}
}

@article{reeves1995-7550346,
  author  = {Reeves, R. H. and Irving, N. G. and Moran, T. H. and Wohn, A. and Kitt, C. and Sisodia, S. S. and Schmidt, C. and Bronson, R. T. and others},
  title   = {{A mouse model for Down syndrome exhibits learning and behaviour deficits}},
  journal = {Nature genetics},
  year    = {1995},
  doi     = {10.1038/ng1095-177},
  pmid    = {7550346},
  url     = {https://doi.org/10.1038/ng1095-177}
}

@article{devenny2000-11115020,
  author  = {Devenny, D. A. and Krinsky-McHale, S. J. and Sersen, G. and Silverman, W. P.},
  title   = {{Sequence of cognitive decline in dementia in adults with Down's syndrome}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2000},
  doi     = {10.1046/j.1365-2788.2000.00305.x},
  pmid    = {11115020},
  url     = {https://doi.org/10.1046/j.1365-2788.2000.00305.x}
}

@article{schupf2010-21041786,
  author  = {Schupf, N. and Zigman, W. B. and Tang, M. X. and Pang, D. and Mayeux, R. and Mehta, P. and Silverman, W.},
  title   = {{Change in plasma Aß peptides and onset of dementia in adults with Down syndrome}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181fb448b},
  pmid    = {21041786},
  url     = {https://doi.org/10.1212/wnl.0b013e3181fb448b}
}

@article{bernhardt2025-40528443,
  author  = {Bernhardt, A. M. and Í, Rodríguez-Baz and Aldecoa, I. and Arranz, J. and Arriola-Infante, J. E. and Maure-Blesa, L. and Carmona-Iragui, M. and Longen, S. and others},
  title   = {{Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70342},
  pmid    = {40528443},
  url     = {https://doi.org/10.1002/alz.70342}
}

@article{alic2021-32647257,
  author  = {Alić, I. and Goh, P. A. and Murray, A. and Portelius, E. and Gkanatsiou, E. and Gough, G. and Mok, K. Y. and Koschut, D. and others},
  title   = {{Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain}},
  journal = {Molecular psychiatry},
  year    = {2021},
  doi     = {10.1038/s41380-020-0806-5},
  pmid    = {32647257},
  url     = {https://doi.org/10.1038/s41380-020-0806-5}
}

@article{beacher2005-16330724,
  author  = {Beacher, F. and Simmons, A. and Daly, E. and Prasher, V. and Adams, C. and Margallo-Lana, M. L. and Morris, R. and Lovestone, S. and others},
  title   = {{Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study}},
  journal = {Archives of general psychiatry},
  year    = {2005},
  doi     = {10.1001/archpsyc.62.12.1360},
  pmid    = {16330724},
  url     = {https://doi.org/10.1001/archpsyc.62.12.1360}
}

@article{belbin2020-32807227,
  author  = {Belbin, O. and Xiao, M. F. and Xu, D. and Carmona-Iragui, M. and Pegueroles, J. and Benejam, B. and Videla, L. and Fernández, S. and others},
  title   = {{Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer's disease-related inhibitory circuit dysfunction in adults with Down syndrome}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00398-0},
  pmid    = {32807227},
  url     = {https://doi.org/10.1186/s13024-020-00398-0}
}

@article{lin2016-27330972,
  author  = {Lin, A. L. and Powell, D. and Caban-Holt, A. and Jicha, G. and Robertson, W. and Gold, B. T. and Davis, R. and Abner, E. and others},
  title   = {{(1)H-MRS metabolites in adults with Down syndrome: Effects of dementia}},
  journal = {NeuroImage. Clinical},
  year    = {2016},
  doi     = {10.1016/j.nicl.2016.06.001},
  pmid    = {27330972},
  url     = {https://doi.org/10.1016/j.nicl.2016.06.001}
}

@article{liu2024-39158850,
  author  = {Liu, L. and Saba, A. and Pascual, JR. and Miller, M. B. and Hennessey, E. L. and Lott, I. T. and Brickman, A. M. and Wilcock, D. M. and others},
  title   = {{Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome}},
  journal = {JAMA neurology},
  year    = {2024},
  doi     = {10.1001/jamaneurol.2024.2579},
  pmid    = {39158850},
  url     = {https://doi.org/10.1001/jamaneurol.2024.2579}
}

@article{pereiradasilva2026-42721539,
  author  = {Pereira da Silva, A. M. and Tudella, G. C. N. and Lee, A. M. and Santos, D. H. and Cukiert, C. M. and Perry, G.},
  title   = {{Epilepsy and subsequent dementia in adults with down syndrome: a propensity score-matched cohort study using federated electronic health records}},
  journal = {Seizure},
  year    = {2026},
  doi     = {10.1016/j.seizure.2026.08.023},
  pmid    = {42721539},
  url     = {https://doi.org/10.1016/j.seizure.2026.08.023}
}

@article{zammit2026-42928420,
  author  = {Zammit, M. D. and Hartley, S. L. and Christian, B. T. and Rafii, M. S.},
  title   = {{Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71925},
  pmid    = {42928420},
  url     = {https://doi.org/10.1002/alz.71925}
}

@article{franceschi2018-29662881,
  author  = {Franceschi, C. and Garagnani, P. and Morsiani, C. and Conte, M. and Santoro, A. and Grignolio, A. and Monti, D. and Capri, M. and others},
  title   = {{The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates}},
  journal = {Frontiers in medicine},
  year    = {2018},
  doi     = {10.3389/fmed.2018.00061},
  pmid    = {29662881},
  url     = {https://doi.org/10.3389/fmed.2018.00061}
}

@article{korenberg1994-8197171,
  author  = {Korenberg, JR. and Chen, X. N. and Schipper, R. and Sun, Z. and Gonsky, R. and Gerwehr, S. and Carpenter, N. and Daumer, C. and others},
  title   = {{Down syndrome phenotypes: the consequences of chromosomal imbalance}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.11.4997},
  pmid    = {8197171},
  url     = {https://doi.org/10.1073/pnas.91.11.4997}
}

@article{hill2003-12639204,
  author  = {Hill, D. A. and Gridley, G. and Cnattingius, S. and Mellemkjaer, L. and Linet, M. and Adami, H. O. and Olsen, J. H. and Nyren, O. and others},
  title   = {{Mortality and cancer incidence among individuals with Down syndrome}},
  journal = {Archives of internal medicine},
  year    = {2003},
  doi     = {10.1001/archinte.163.6.705},
  pmid    = {12639204},
  url     = {https://doi.org/10.1001/archinte.163.6.705}
}

@article{hartley2015-25510383,
  author  = {Hartley, D. and Blumenthal, T. and Carrillo, M. and DiPaolo, G. and Esralew, L. and Gardiner, K. and Granholm, A. C. and Iqbal, K. and others},
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