% alzhub.org library filter % Source: https://alzhub.org/research?author=Sperling+RA % 55 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{sperling2023-37458272, author = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Rafii, M. S. and Johnson, K. and Masters, C. L. and van Dyck, C. H. and Iwatsubo, T. and others}, title = {{Trial of Solanezumab in Preclinical Alzheimer's Disease}}, journal = {The New England journal of medicine}, year = {2023}, doi = {10.1056/nejmoa2305032}, pmid = {37458272}, url = {https://doi.org/10.1056/nejmoa2305032} } @article{honig2024-38730496, author = {Honig, L. S. and Sabbagh, M. N. and van Dyck, C. H. and Sperling, R. A. and Hersch, S. and Matta, A. and Giorgi, L. and Gee, M. and others}, title = {{Updated safety results from phase 3 lecanemab study in early Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01441-8}, pmid = {38730496}, url = {https://doi.org/10.1186/s13195-024-01441-8} } @article{sperling2024-39044488, author = {Sperling, R. A. and Donohue, M. C. and Rissman, R. A. and Johnson, K. A. and Rentz, D. M. and Grill, J. D. and Heidebrink, J. L. and Jenkins, C. and others}, title = {{Amyloid and Tau Prediction of Cognitive and Functional Decline in Unimpaired Older Individuals: Longitudinal Data from the A4 and LEARN Studies}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.122}, pmid = {39044488}, url = {https://doi.org/10.14283/jpad.2024.122} } @article{donohue2017-28609533, author = {Donohue, M. C. and Sperling, R. A. and Petersen, R. and Sun, C. K. and Weiner, M. W. and Aisen, P. S. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons}}, journal = {JAMA}, year = {2017}, doi = {10.1001/jama.2017.6669}, pmid = {28609533}, url = {https://doi.org/10.1001/jama.2017.6669} } @article{papp2017-29264389, author = {Papp, K. V. and Rentz, D. M. and Orlovsky, I. and Sperling, R. A. and Mormino, E. C.}, title = {{Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2017}, doi = {10.1016/j.trci.2017.10.004}, pmid = {29264389}, url = {https://doi.org/10.1016/j.trci.2017.10.004} } @article{sperling2011-21514248, author = {Sperling, R. A. and Aisen, P. S. and Beckett, L. A. and Bennett, D. A. and Craft, S. and Fagan, A. M. and Iwatsubo, T. and Jack, C. R. and others}, title = {{Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2011}, doi = {10.1016/j.jalz.2011.03.003}, pmid = {21514248}, url = {https://doi.org/10.1016/j.jalz.2011.03.003} } @article{insel2025-40853684, author = {Insel, P. S. and Mattsson-Carlgren, N. and Langford, O. and Caruso, V. M. and Leuzy, A. and Young, C. B. and Boxer, A. and Aisen, P. S. and Sperling, R. A. and Mormino, E. C. and Donohue, M. C.}, title = {{Concurrent Changes in Plasma Phosphorylated Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.2974}, pmid = {40853684}, url = {https://doi.org/10.1001/jamaneurol.2025.2974} } @article{sperling2020-32250387, author = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Sun, C. K. and Yaari, R. and Holdridge, K. and Siemers, E. and Johnson, K. A. and others}, title = {{Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.0387}, pmid = {32250387}, url = {https://doi.org/10.1001/jamaneurol.2020.0387} } @article{dubbelman2025-40440591, author = {Dubbelman, M. A. and Liu, A. and Donohue, M. C. and Langford, O. and Raman, R. and Rentz, D. M. and Amariglio, R. and Sperling, R. A. and others}, title = {{Changes in Daily Functioning in Association With Tau and Amyloid Among Unimpaired Older Adults With and Without Elevated Amyloid}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213775}, pmid = {40440591}, url = {https://doi.org/10.1212/wnl.0000000000213775} } @article{doraiswamy2012-22786606, author = {Doraiswamy, P. M. and Sperling, R. A. and Coleman, R. E. and Johnson, K. A. and Reiman, E. M. and Davis, M. D. and Grundman, M. and Sabbagh, M. N. and others}, title = {{Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182661f74}, pmid = {22786606}, url = {https://doi.org/10.1212/wnl.0b013e3182661f74} } @article{donohue2014-24886908, author = {Donohue, M. C. and Sperling, R. A. and Salmon, D. P. and Rentz, D. M. and Raman, R. and Thomas, R. G. and Weiner, M. and Aisen, P. S. and others}, title = {{The preclinical Alzheimer cognitive composite: measuring amyloid-related decline}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.803}, pmid = {24886908}, url = {https://doi.org/10.1001/jamaneurol.2014.803} } @article{rentz2024-39044489, author = {Rentz, D. M. and Rosenberg, P. B. and Sperling, R. A. and Donohue, M. C. and Raman, R. and Liu, A. and Aisen, P. S.}, title = {{Characterizing Clinical Progression in Cognitively Unimpaired Older Individuals with Brain Amyloid: Results from the A4 Study}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.123}, pmid = {39044489}, url = {https://doi.org/10.14283/jpad.2024.123} } @article{amariglio2024-39044492, author = {Amariglio, R. E. and Grill, J. D. and Rentz, D. M. and Marshall, G. A. and Donohue, M. C. and Liu, A. and Aisen, P. S. and Sperling, R. A.}, title = {{Longitudinal Trajectories of the Cognitive Function Index in the A4 Study}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.125}, pmid = {39044492}, url = {https://doi.org/10.14283/jpad.2024.125} } @article{ge2018-29592889, author = {Ge, T. and Sabuncu, M. R. and Smoller, J. W. and Sperling, R. A. and Mormino, E. C. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005415}, pmid = {29592889}, url = {https://doi.org/10.1212/wnl.0000000000005415} } @article{dickerson2011-21490323, author = {Dickerson, B. C. and Stoub, T. R. and Shah, R. C. and Sperling, R. A. and Killiany, R. J. and Albert, M. S. and Hyman, B. T. and Blacker, D. and others}, title = {{Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e3182166e96}, pmid = {21490323}, url = {https://doi.org/10.1212/wnl.0b013e3182166e96} } @article{yang2018-30093249, author = {Yang, H. S. and Yu, L. and White, C. C. and Chibnik, L. B. and Chhatwal, J. P. and Sperling, R. A. and Bennett, D. A. and Schneider, J. A. and others}, title = {{Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(18)30251-5}, pmid = {30093249}, url = {https://doi.org/10.1016/s1474-4422(18)30251-5} } @article{young2022-35435938, author = {Young, C. B. and Winer, JR. and Younes, K. and Cody, K. A. and Betthauser, T. J. and Johnson, S. C. and Schultz, A. and Sperling, R. A. and others}, title = {{Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.0676}, pmid = {35435938}, url = {https://doi.org/10.1001/jamaneurol.2022.0676} } @article{obrien2010-20463288, author = {O'Brien, J. L. and O'Keefe, K. M. and LaViolette, P. S. and DeLuca, A. N. and Blacker, D. and Dickerson, B. C. and Sperling, R. A.}, title = {{Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181e3966e}, pmid = {20463288}, url = {https://doi.org/10.1212/wnl.0b013e3181e3966e} } @article{johnson2013-23375563, author = {Johnson, K. A. and Sperling, R. A. and Gidicsin, C. M. and Carmasin, J. S. and Maye, J. E. and Coleman, R. E. and Reiman, E. M. and Sabbagh, M. N. and others}, title = {{Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2013}, doi = {10.1016/j.jalz.2012.10.007}, pmid = {23375563}, url = {https://doi.org/10.1016/j.jalz.2012.10.007} } @article{dickerson2007-18056553, author = {Dickerson, B. C. and Sperling, R. A. and Hyman, B. T. and Albert, M. S. and Blacker, D.}, title = {{Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment}}, journal = {Archives of general psychiatry}, year = {2007}, doi = {10.1001/archpsyc.64.12.1443}, pmid = {18056553}, url = {https://doi.org/10.1001/archpsyc.64.12.1443} } @article{donovan2018-29325447, author = {Donovan, N. J. and Locascio, J. J. and Marshall, G. A. and Gatchel, J. and Hanseeuw, B. J. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and others}, title = {{Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults}}, journal = {The American journal of psychiatry}, year = {2018}, doi = {10.1176/appi.ajp.2017.17040442}, pmid = {29325447}, url = {https://doi.org/10.1176/appi.ajp.2017.17040442} } @article{mormino2016-27385740, author = {Mormino, E. C. and Sperling, R. A. and Holmes, A. J. and Buckner, R. L. and De Jager, P. L. and Smoller, J. W. and Sabuncu, M. R. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Polygenic risk of Alzheimer disease is associated with early- and late-life processes}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000002922}, pmid = {27385740}, url = {https://doi.org/10.1212/wnl.0000000000002922} } @article{quiroz2018-29435558, author = {Quiroz, Y. T. and Sperling, R. A. and Norton, D. J. and Baena, A. and Arboleda-Velasquez, J. F. and Cosio, D. and Schultz, A. and Lapoint, M. and others}, title = {{Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2017.4907}, pmid = {29435558}, url = {https://doi.org/10.1001/jamaneurol.2017.4907} } @article{donovan2016-27806159, author = {Donovan, N. J. and Okereke, O. I. and Vannini, P. and Amariglio, R. E. and Rentz, D. M. and Marshall, G. A. and Johnson, K. A. and Sperling, R. A.}, title = {{Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults}}, journal = {JAMA psychiatry}, year = {2016}, doi = {10.1001/jamapsychiatry.2016.2657}, pmid = {27806159}, url = {https://doi.org/10.1001/jamapsychiatry.2016.2657} } @article{mormino2014-25222039, author = {Mormino, E. C. and Betensky, R. A. and Hedden, T. and Schultz, A. P. and Amariglio, R. E. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A.}, title = {{Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.2031}, pmid = {25222039}, url = {https://doi.org/10.1001/jamaneurol.2014.2031} } @article{ghanbarian2025-41268784, author = {Ghanbarian, E. and Qian, T. and Khorsand, B. and Zheng, L. and Sajjadi, S. A. and Grill, J. D. and Rabin, L. A. and Lipton, R. B. and Sperling, R. A. and Ezzati, A.}, title = {{Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70948}, pmid = {41268784}, url = {https://doi.org/10.1002/alz.70948} } @article{black2010-20505438, author = {Black, R. S. and Sperling, R. A. and Safirstein, B. and Motter, R. N. and Pallay, A. and Nichols, A. and Grundman, M.}, title = {{A single ascending dose study of bapineuzumab in patients with Alzheimer disease}}, journal = {Alzheimer disease and associated disorders}, year = {2010}, doi = {10.1097/wad.0b013e3181c53b00}, pmid = {20505438}, url = {https://doi.org/10.1097/wad.0b013e3181c53b00} } @article{jack2011-21514247, author = {Jack, C. R. and Albert, M. S. and Knopman, D. S. and McKhann, G. M. and Sperling, R. A. and Carrillo, M. C. and Thies, B. and Phelps, C. H.}, title = {{Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2011}, doi = {10.1016/j.jalz.2011.03.004}, pmid = {21514247}, url = {https://doi.org/10.1016/j.jalz.2011.03.004} } @article{marshall2011-21575871, author = {Marshall, G. A. and Rentz, D. M. and Frey, M. T. and Locascio, J. J. and Johnson, K. A. and Sperling, R. A. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2011}, doi = {10.1016/j.jalz.2010.04.005}, pmid = {21575871}, url = {https://doi.org/10.1016/j.jalz.2010.04.005} } @article{sperling2014-24648338, author = {Sperling, R. A. and Rentz, D. M. and Johnson, K. A. and Karlawish, J. and Donohue, M. and Salmon, D. P. and Aisen, P.}, title = {{The A4 study: stopping AD before symptoms begin?}}, journal = {Science translational medicine}, year = {2014}, doi = {10.1126/scitranslmed.3007941}, pmid = {24648338}, url = {https://doi.org/10.1126/scitranslmed.3007941} } @article{rentz2021-33589537, author = {Rentz, D. M. and Papp, K. V. and Mayblyum, D. V. and Sanchez, J. S. and Klein, H. and Souillard-Mandar, W. and Sperling, R. A. and Johnson, K. A.}, title = {{Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011697}, pmid = {33589537}, url = {https://doi.org/10.1212/wnl.0000000000011697} } @article{donovan2014-23890751, author = {Donovan, N. J. and Wadsworth, L. P. and Lorius, N. and Locascio, J. J. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and Marshall, G. A. and others}, title = {{Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2014}, doi = {10.1016/j.jagp.2013.03.006}, pmid = {23890751}, url = {https://doi.org/10.1016/j.jagp.2013.03.006} } @article{doraiswamy2014-24614494, author = {Doraiswamy, P. M. and Sperling, R. A. and Johnson, K. and Reiman, E. M. and Wong, T. Z. and Sabbagh, M. N. and Sadowsky, C. H. and Fleisher, A. S. and others}, title = {{Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study}}, journal = {Molecular psychiatry}, year = {2014}, doi = {10.1038/mp.2014.9}, pmid = {24614494}, url = {https://doi.org/10.1038/mp.2014.9} } @article{growdon2015-25934852, author = {Growdon, M. E. and Schultz, A. P. and Dagley, A. S. and Amariglio, R. E. and Hedden, T. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and others}, title = {{Odor identification and Alzheimer disease biomarkers in clinically normal elderly}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001614}, pmid = {25934852}, url = {https://doi.org/10.1212/wnl.0000000000001614} } @article{replogle2015-25545807, author = {Replogle, J. M. and Chan, G. and White, C. C. and Raj, T. and Winn, P. A. and Evans, D. A. and Sperling, R. A. and Chibnik, L. B. and others}, title = {{A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology}}, journal = {Annals of neurology}, year = {2015}, doi = {10.1002/ana.24337}, pmid = {25545807}, url = {https://doi.org/10.1002/ana.24337} } @article{johnson2012-22474610, author = {Johnson, K. A. and Fox, N. C. and Sperling, R. A. and Klunk, W. E.}, title = {{Brain imaging in Alzheimer disease}}, journal = {Cold Spring Harbor perspectives in medicine}, year = {2012}, doi = {10.1101/cshperspect.a006213}, pmid = {22474610}, url = {https://doi.org/10.1101/cshperspect.a006213} } @article{sabuncu2012-22169231, author = {Sabuncu, M. R. and Buckner, R. L. and Smoller, J. W. and Lee, P. H. and Fischl, B. and Sperling, R. A. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects}}, journal = {Cerebral cortex (New York, N.Y. : 1991)}, year = {2012}, doi = {10.1093/cercor/bhr348}, pmid = {22169231}, url = {https://doi.org/10.1093/cercor/bhr348} } @article{ewers2011-21696834, author = {Ewers, M. and Sperling, R. A. and Klunk, W. E. and Weiner, M. W. and Hampel, H.}, title = {{Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia}}, journal = {Trends in neurosciences}, year = {2011}, doi = {10.1016/j.tins.2011.05.005}, pmid = {21696834}, url = {https://doi.org/10.1016/j.tins.2011.05.005} } @article{beyrer2026-41926844, author = {Beyrer, J. and Sheff, Z. and Payakachat, N. and Chandler, J. M. and Chen, Y. F. and Kubisiak, J. and Lee, A. and Holdridge, K. C. and Yaari, R. and Aisen, P. and Rafii, M. S. and Sperling, R. A. and others}, title = {{Increase in healthcare utilization and Medicare payment with progression of preclinical Alzheimer's disease}}, journal = {Journal of Prevention of Alzheimer's Disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100547}, pmid = {41926844}, url = {https://doi.org/10.1016/j.tjpad.2026.100547} } @article{rafii2023-35971310, author = {Rafii, M. S. and Sperling, R. A. and Donohue, M. C. and Zhou, J. and Roberts, C. and Irizarry, M. C. and Dhadda, S. and Sethuraman, G. and others}, title = {{The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.12748}, pmid = {35971310}, url = {https://doi.org/10.1002/alz.12748} } @article{rentz2010-20373347, author = {Rentz, D. M. and Locascio, J. J. and Becker, J. A. and Moran, E. K. and Eng, E. and Buckner, R. L. and Sperling, R. A. and Johnson, K. A.}, title = {{Cognition, reserve, and amyloid deposition in normal aging}}, journal = {Annals of neurology}, year = {2010}, doi = {10.1002/ana.21904}, pmid = {20373347}, url = {https://doi.org/10.1002/ana.21904} } @article{grober2022-35197359, author = {Grober, E. and Lipton, R. B. and Sperling, R. A. and Papp, K. V. and Johnson, K. A. and Rentz, D. M. and Veroff, A. E. and Aisen, P. S. and others}, title = {{Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200046}, pmid = {35197359}, url = {https://doi.org/10.1212/wnl.0000000000200046} } @article{halawa2019-30704519, author = {Halawa, O. A. and Gatchel, JR. and Amariglio, R. E. and Rentz, D. M. and Sperling, R. A. and Johnson, K. A. and Marshall, G. A. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2019}, doi = {10.1186/s13195-019-0471-6}, pmid = {30704519}, url = {https://doi.org/10.1186/s13195-019-0471-6} } @article{wadsworth2012-22922821, author = {Wadsworth, L. P. and Lorius, N. and Donovan, N. J. and Locascio, J. J. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and Marshall, G. A.}, title = {{Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum}}, journal = {Dementia and geriatric cognitive disorders}, year = {2012}, doi = {10.1159/000342119}, pmid = {22922821}, url = {https://doi.org/10.1159/000342119} } @article{miller2008-17846109, author = {Miller, S. L. and Fenstermacher, E. and Bates, J. and Blacker, D. and Sperling, R. A. and Dickerson, B. 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