% alzhub.org library filter
% Source: https://alzhub.org/research?author=Holtzman+DM
% 74 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{paczynski2025-40354064,
  author  = {Paczynski, M. and Hofmann, A. and Posey, Z. and Gregersen, M. and Rudman, M. and Ellington, D. and Aldinger, M. and Musiek, E. S. and Holtzman, D. M. and Bateman, R. J. and others},
  title   = {{Lecanemab Treatment in a Specialty Memory Clinic}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.1232},
  pmid    = {40354064},
  url     = {https://doi.org/10.1001/jamaneurol.2025.1232}
}

@article{piccio2016-26754641,
  author  = {Piccio, L. and Deming, Y. and Del-Águila, J. L. and Ghezzi, L. and Holtzman, D. M. and Fagan, A. M. and Fenoglio, C. and Galimberti, D. and others},
  title   = {{Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-016-1533-5},
  pmid    = {26754641},
  url     = {https://doi.org/10.1007/s00401-016-1533-5}
}

@article{fagan2007-17210801,
  author  = {Fagan, A. M. and Roe, C. M. and Xiong, C. and Mintun, M. A. and Morris, J. C. and Holtzman, D. M.},
  title   = {{Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.3.noc60123},
  pmid    = {17210801},
  url     = {https://doi.org/10.1001/archneur.64.3.noc60123}
}

@article{ju2013-23479184,
  author  = {Ju, Y. E. and McLeland, J. S. and Toedebusch, C. D. and Xiong, C. and Fagan, A. M. and Duntley, S. P. and Morris, J. C. and Holtzman, D. M.},
  title   = {{Sleep quality and preclinical Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.2334},
  pmid    = {23479184},
  url     = {https://doi.org/10.1001/jamaneurol.2013.2334}
}

@article{meyerluehmann2008-18256671,
  author  = {Meyer-Luehmann, M. and Spires-Jones, T. L. and Prada, C. and Garcia-Alloza, M. and de Calignon, A. and Rozkalne, A. and Koenigsknecht-Talboo, J. and Holtzman, D. M. and others},
  title   = {{Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease}},
  journal = {Nature},
  year    = {2008},
  doi     = {10.1038/nature06616},
  pmid    = {18256671},
  url     = {https://doi.org/10.1038/nature06616}
}

@article{self2023-37667136,
  author  = {Self, W. K. and Holtzman, D. M.},
  title   = {{Emerging diagnostics and therapeutics for Alzheimer disease}},
  journal = {Nature medicine},
  year    = {2023},
  doi     = {10.1038/s41591-023-02505-2},
  pmid    = {37667136},
  url     = {https://doi.org/10.1038/s41591-023-02505-2}
}

@article{jack2018-29653606,
  author  = {Jack, C. R. and Bennett, D. A. and Blennow, K. and Carrillo, M. C. and Dunn, B. and Haeberlein, S. B. and Holtzman, D. M. and Jagust, W. and others},
  title   = {{NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2018},
  doi     = {10.1016/j.jalz.2018.02.018},
  pmid    = {29653606},
  url     = {https://doi.org/10.1016/j.jalz.2018.02.018}
}

@article{vlassenko2016-27398953,
  author  = {Vlassenko, A. G. and McCue, L. and Jasielec, M. S. and Su, Y. and Gordon, B. A. and Xiong, C. and Holtzman, D. M. and Benzinger, T. L. and others},
  title   = {{Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2016},
  doi     = {10.1002/ana.24719},
  pmid    = {27398953},
  url     = {https://doi.org/10.1002/ana.24719}
}

@article{gordon2016-27548756,
  author  = {Gordon, B. A. and Blazey, T. and Su, Y. and Fagan, A. M. and Holtzman, D. M. and Morris, J. C. and Benzinger, T. L.},
  title   = {{Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology}},
  journal = {JAMA neurology},
  year    = {2016},
  doi     = {10.1001/jamaneurol.2016.2642},
  pmid    = {27548756},
  url     = {https://doi.org/10.1001/jamaneurol.2016.2642}
}

@article{schindler2019-31371569,
  author  = {Schindler, S. E. and Bollinger, J. G. and Ovod, V. and Mawuenyega, K. G. and Li, Y. and Gordon, B. A. and Holtzman, D. M. and Morris, J. C. and others},
  title   = {{High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis}},
  journal = {Neurology},
  year    = {2019},
  doi     = {10.1212/wnl.0000000000008081},
  pmid    = {31371569},
  url     = {https://doi.org/10.1212/wnl.0000000000008081}
}

@article{morris2010-20186853,
  author  = {Morris, J. C. and Roe, C. M. and Xiong, C. and Fagan, A. M. and Goate, A. M. and Holtzman, D. M. and Mintun, M. A.},
  title   = {{APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.21843},
  pmid    = {20186853},
  url     = {https://doi.org/10.1002/ana.21843}
}

@article{musiek2018-29379963,
  author  = {Musiek, E. S. and Bhimasani, M. and Zangrilli, M. A. and Morris, J. C. and Holtzman, D. M. and Ju, Y. S.},
  title   = {{Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2017.4719},
  pmid    = {29379963},
  url     = {https://doi.org/10.1001/jamaneurol.2017.4719}
}

@article{bell2012-22622580,
  author  = {Bell, R. D. and Winkler, E. A. and Singh, I. and Sagare, A. P. and Deane, R. and Wu, Z. and Holtzman, D. M. and Betsholtz, C. and others},
  title   = {{Apolipoprotein E controls cerebrovascular integrity via cyclophilin A}},
  journal = {Nature},
  year    = {2012},
  doi     = {10.1038/nature11087},
  pmid    = {22622580},
  url     = {https://doi.org/10.1038/nature11087}
}

@article{mishra2018-29672664,
  author  = {Mishra, S. and Blazey, T. M. and Holtzman, D. M. and Cruchaga, C. and Su, Y. and Morris, J. C. and Benzinger, T. L. S. and Gordon, B. A.},
  title   = {{Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awy103},
  pmid    = {29672664},
  url     = {https://doi.org/10.1093/brain/awy103}
}

@article{morris2009-20008650,
  author  = {Morris, J. C. and Roe, C. M. and Grant, E. A. and Head, D. and Storandt, M. and Goate, A. M. and Fagan, A. M. and Holtzman, D. M. and others},
  title   = {{Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2009.269},
  pmid    = {20008650},
  url     = {https://doi.org/10.1001/archneurol.2009.269}
}

@article{thomas2014-25069482,
  author  = {Thomas, J. B. and Brier, M. R. and Bateman, R. J. and Snyder, A. Z. and Benzinger, T. L. and Xiong, C. and Raichle, M. and Holtzman, D. M. and others},
  title   = {{Functional connectivity in autosomal dominant and late-onset Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1654},
  pmid    = {25069482},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1654}
}

@article{snider2009-19433664,
  author  = {Snider, B. J. and Fagan, A. M. and Roe, C. and Shah, A. R. and Grant, E. A. and Xiong, C. and Morris, J. C. and Holtzman, D. M.},
  title   = {{Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2009.55},
  pmid    = {19433664},
  url     = {https://doi.org/10.1001/archneurol.2009.55}
}

@article{brier2012-22745490,
  author  = {Brier, M. R. and Thomas, J. B. and Snyder, A. Z. and Benzinger, T. L. and Zhang, D. and Raichle, M. E. and Holtzman, D. M. and Morris, J. C. and others},
  title   = {{Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.5698-11.2012},
  pmid    = {22745490},
  url     = {https://doi.org/10.1523/jneurosci.5698-11.2012}
}

@article{tarawneh2015-25867677,
  author  = {Tarawneh, R. and Head, D. and Allison, S. and Buckles, V. and Fagan, A. M. and Ladenson, J. H. and Morris, J. C. and Holtzman, D. M.},
  title   = {{Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2015.0202},
  pmid    = {25867677},
  url     = {https://doi.org/10.1001/jamaneurol.2015.0202}
}

@article{hu2012-22855860,
  author  = {Hu, W. T. and Holtzman, D. M. and Fagan, A. M. and Shaw, L. M. and Perrin, R. and Arnold, S. E. and Grossman, M. and Xiong, C. and others},
  title   = {{Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e318266fa70},
  pmid    = {22855860},
  url     = {https://doi.org/10.1212/wnl.0b013e318266fa70}
}

@article{martens2022-35298921,
  author  = {Martens, Y. A. and Zhao, N. and Liu, C. C. and Kanekiyo, T. and Yang, A. J. and Goate, A. M. and Holtzman, D. M. and Bu, G.},
  title   = {{ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias}},
  journal = {Neuron},
  year    = {2022},
  doi     = {10.1016/j.neuron.2022.03.004},
  pmid    = {35298921},
  url     = {https://doi.org/10.1016/j.neuron.2022.03.004}
}

@article{bateman2006-16799555,
  author  = {Bateman, R. J. and Munsell, L. Y. and Morris, J. C. and Swarm, R. and Yarasheski, K. E. and Holtzman, D. M.},
  title   = {{Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo}},
  journal = {Nature medicine},
  year    = {2006},
  doi     = {10.1038/nm1438},
  pmid    = {16799555},
  url     = {https://doi.org/10.1038/nm1438}
}

@article{babulal2016-27426238,
  author  = {Babulal, G. M. and Ghoshal, N. and Head, D. and Vernon, E. K. and Holtzman, D. M. and Benzinger, T. L. S. and Fagan, A. M. and Morris, J. C. and others},
  title   = {{Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2016},
  doi     = {10.1016/j.jagp.2016.04.004},
  pmid    = {27426238},
  url     = {https://doi.org/10.1016/j.jagp.2016.04.004}
}

@article{perrin2009-19829371,
  author  = {Perrin, R. J. and Fagan, A. M. and Holtzman, D. M.},
  title   = {{Multimodal techniques for diagnosis and prognosis of Alzheimer's disease}},
  journal = {Nature},
  year    = {2009},
  doi     = {10.1038/nature08538},
  pmid    = {19829371},
  url     = {https://doi.org/10.1038/nature08538}
}

@article{holtzman2011-21471435,
  author  = {Holtzman, D. M. and Morris, J. C. and Goate, A. M.},
  title   = {{Alzheimer's disease: the challenge of the second century}},
  journal = {Science translational medicine},
  year    = {2011},
  doi     = {10.1126/scitranslmed.3002369},
  pmid    = {21471435},
  url     = {https://doi.org/10.1126/scitranslmed.3002369}
}

@article{deane2008-19033669,
  author  = {Deane, R. and Sagare, A. and Hamm, K. and Parisi, M. and Lane, S. and Finn, M. B. and Holtzman, D. M. and Zlokovic, B. V.},
  title   = {{apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci36663},
  pmid    = {19033669},
  url     = {https://doi.org/10.1172/jci36663}
}

@article{jain2023-36219197,
  author  = {Jain, N. and Lewis, C. A. and Ulrich, J. D. and Holtzman, D. M.},
  title   = {{Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading}},
  journal = {The Journal of experimental medicine},
  year    = {2023},
  doi     = {10.1084/jem.20220654},
  pmid    = {36219197},
  url     = {https://doi.org/10.1084/jem.20220654}
}

@article{shi2018-30140051,
  author  = {Shi, Y. and Holtzman, D. M.},
  title   = {{Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight}},
  journal = {Nature reviews. Immunology},
  year    = {2018},
  doi     = {10.1038/s41577-018-0051-1},
  pmid    = {30140051},
  url     = {https://doi.org/10.1038/s41577-018-0051-1}
}

@article{faraco2019-31645758,
  author  = {Faraco, G. and Hochrainer, K. and Segarra, S. G. and Schaeffer, S. and Santisteban, M. M. and Menon, A. and Jiang, H. and Holtzman, D. M. and others},
  title   = {{Dietary salt promotes cognitive impairment through tau phosphorylation}},
  journal = {Nature},
  year    = {2019},
  doi     = {10.1038/s41586-019-1688-z},
  pmid    = {31645758},
  url     = {https://doi.org/10.1038/s41586-019-1688-z}
}

@article{gratuze2018-30572908,
  author  = {Gratuze, M. and Leyns, C. E. G. and Holtzman, D. M.},
  title   = {{New insights into the role of TREM2 in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0298-9},
  pmid    = {30572908},
  url     = {https://doi.org/10.1186/s13024-018-0298-9}
}

@article{ulrich2017-28426958,
  author  = {Ulrich, J. D. and Ulland, T. K. and Colonna, M. and Holtzman, D. M.},
  title   = {{Elucidating the Role of TREM2 in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.02.042},
  pmid    = {28426958},
  url     = {https://doi.org/10.1016/j.neuron.2017.02.042}
}

@article{leyns2017-28662669,
  author  = {Leyns, C. E. G. and Holtzman, D. M.},
  title   = {{Glial contributions to neurodegeneration in tauopathies}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0192-x},
  pmid    = {28662669},
  url     = {https://doi.org/10.1186/s13024-017-0192-x}
}

@article{chen2021-33176118,
  author  = {Chen, Y. and Strickland, M. R. and Soranno, A. and Holtzman, D. M.},
  title   = {{Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2020.10.008},
  pmid    = {33176118},
  url     = {https://doi.org/10.1016/j.neuron.2020.10.008}
}

@article{tarawneh2012-22357717,
  author  = {Tarawneh, R. and Lee, J. M. and Ladenson, J. H. and Morris, J. C. and Holtzman, D. M.},
  title   = {{CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e318248e568},
  pmid    = {22357717},
  url     = {https://doi.org/10.1212/wnl.0b013e318248e568}
}

@article{mahan2022-35109920,
  author  = {Mahan, T. E. and Wang, C. and Bao, X. and Choudhury, A. and Ulrich, J. D. and Holtzman, D. M.},
  title   = {{Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00516-0},
  pmid    = {35109920},
  url     = {https://doi.org/10.1186/s13024-022-00516-0}
}

@article{ju2014-24366271,
  author  = {Ju, Y. E. and Lucey, B. P. and Holtzman, D. M.},
  title   = {{Sleep and Alzheimer disease pathology--a bidirectional relationship}},
  journal = {Nature reviews. Neurology},
  year    = {2014},
  doi     = {10.1038/nrneurol.2013.269},
  pmid    = {24366271},
  url     = {https://doi.org/10.1038/nrneurol.2013.269}
}

@article{esparza2013-23225543,
  author  = {Esparza, T. J. and Zhao, H. and Cirrito, JR. and Cairns, N. J. and Bateman, R. J. and Holtzman, D. M. and Brody, D. L.},
  title   = {{Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23748},
  pmid    = {23225543},
  url     = {https://doi.org/10.1002/ana.23748}
}

@article{musiek2015-25766617,
  author  = {Musiek, E. S. and Xiong, D. D. and Holtzman, D. M.},
  title   = {{Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease}},
  journal = {Experimental \& molecular medicine},
  year    = {2015},
  doi     = {10.1038/emm.2014.121},
  pmid    = {25766617},
  url     = {https://doi.org/10.1038/emm.2014.121}
}

@article{holtzman2012-22393530,
  author  = {Holtzman, D. M. and Herz, J. and Bu, G.},
  title   = {{Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
  doi     = {10.1101/cshperspect.a006312},
  pmid    = {22393530},
  url     = {https://doi.org/10.1101/cshperspect.a006312}
}

@article{wang2013-23959173,
  author  = {Wang, L. and Brier, M. R. and Snyder, A. Z. and Thomas, J. B. and Fagan, A. M. and Xiong, C. and Benzinger, T. L. and Holtzman, D. M. and others},
  title   = {{Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.3253},
  pmid    = {23959173},
  url     = {https://doi.org/10.1001/jamaneurol.2013.3253}
}

@article{kfoury2012-22461630,
  author  = {Kfoury, N. and Holmes, B. B. and Jiang, H. and Holtzman, D. M. and Diamond, M. I.},
  title   = {{Trans-cellular propagation of Tau aggregation by fibrillar species}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.346072},
  pmid    = {22461630},
  url     = {https://doi.org/10.1074/jbc.m112.346072}
}

@article{kanekiyo2013-24305823,
  author  = {Kanekiyo, T. and Cirrito, JR. and Liu, C. C. and Shinohara, M. and Li, J. and Schuler, D. R. and Holtzman, D. M. and others},
  title   = {{Neuronal clearance of amyloid-β by endocytic receptor LRP1}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2013},
  doi     = {10.1523/jneurosci.3487-13.2013},
  pmid    = {24305823},
  url     = {https://doi.org/10.1523/jneurosci.3487-13.2013}
}

@article{wahrle2005-16207708,
  author  = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Hartman, R. E. and Bales, K. R. and Paul, S. M. and Holtzman, D. M.},
  title   = {{Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508780200},
  pmid    = {16207708},
  url     = {https://doi.org/10.1074/jbc.m508780200}
}

@article{basak2012-22383525,
  author  = {Basak, J. M. and Verghese, P. B. and Yoon, H. and Kim, J. and Holtzman, D. M.},
  title   = {{Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m111.288746},
  pmid    = {22383525},
  url     = {https://doi.org/10.1074/jbc.m111.288746}
}

@article{holtzman1996-8917591,
  author  = {Holtzman, D. M. and Santucci, D. and Kilbridge, J. and Chua-Couzens, J. and Fontana, D. J. and Daniels, S. E. and Johnson, R. M. and Chen, K. and others},
  title   = {{Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1996},
  doi     = {10.1073/pnas.93.23.13333},
  pmid    = {8917591},
  url     = {https://doi.org/10.1073/pnas.93.23.13333}
}

@article{holtzman1995-7568158,
  author  = {Holtzman, D. M. and Pitas, R. E. and Kilbridge, J. and Nathan, B. and Mahley, R. W. and Bu, G. and Schwartz, A. L.},
  title   = {{Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
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  pmid    = {7568158},
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}

@article{kang2018-29040522,
  author  = {Kang, S. S. and Kurti, A. and Baker, K. E. and Liu, C. C. and Colonna, M. and Ulrich, J. D. and Holtzman, D. M. and Bu, G. and others},
  title   = {{Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal}},
  journal = {Human molecular genetics},
  year    = {2018},
  doi     = {10.1093/hmg/ddx366},
  pmid    = {29040522},
  url     = {https://doi.org/10.1093/hmg/ddx366}
}

@article{clifford2009-19907013,
  author  = {Clifford, D. B. and Fagan, A. M. and Holtzman, D. M. and Morris, J. C. and Teshome, M. and Shah, A. R. and Kauwe, J. S.},
  title   = {{CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease}},
  journal = {Neurology},
  year    = {2009},
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  pmid    = {19907013},
  url     = {https://doi.org/10.1212/wnl.0b013e3181c5b445}
}

@article{fagan2009-19260027,
  author  = {Fagan, A. M. and Head, D. and Shah, A. R. and Marcus, D. and Mintun, M. and Morris, J. C. and Holtzman, D. M.},
  title   = {{Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly}},
  journal = {Annals of neurology},
  year    = {2009},
  doi     = {10.1002/ana.21559},
  pmid    = {19260027},
  url     = {https://doi.org/10.1002/ana.21559}
}

@article{liang2010-20818789,
  author  = {Liang, K. Y. and Mintun, M. A. and Fagan, A. M. and Goate, A. M. and Bugg, J. M. and Holtzman, D. M. and Morris, J. C. and Head, D.},
  title   = {{Exercise and Alzheimer's disease biomarkers in cognitively normal older adults}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.22096},
  pmid    = {20818789},
  url     = {https://doi.org/10.1002/ana.22096}
}

@article{xu2021-32366951,
  author  = {Xu, Y. and Du, S. and Marsh, J. A. and Horie, K. and Sato, C. and Ballabio, A. and Karch, C. M. and Holtzman, D. M. and others},
  title   = {{TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading}},
  journal = {Molecular psychiatry},
  year    = {2021},
  doi     = {10.1038/s41380-020-0738-0},
  pmid    = {32366951},
  url     = {https://doi.org/10.1038/s41380-020-0738-0}
}

@article{winer2013-23147550,
  author  = {Winer, L. and Srinivasan, D. and Chun, S. and Lacomis, D. and Jaffa, M. and Fagan, A. and Holtzman, D. M. and Wancewicz, E. and others},
  title   = {{SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.593},
  pmid    = {23147550},
  url     = {https://doi.org/10.1001/jamaneurol.2013.593}
}

@article{wang2012-22156755,
  author  = {Wang, L. and Fagan, A. M. and Shah, A. R. and Beg, M. F. and Csernansky, J. G. and Morris, J. C. and Holtzman, D. M.},
  title   = {{Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2012},
  doi     = {10.1097/wad.0b013e31823c0cf4},
  pmid    = {22156755},
  url     = {https://doi.org/10.1097/wad.0b013e31823c0cf4}
}

@article{noh2026-42676462,
  author  = {Noh, M. Y. and Sung, W. and Kim, H. and Son, B. and Kim, Y. E. and Choi, Y. Y. and Holtzman, D. M. and Kim, S. H.},
  title   = {{Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2026},
  doi     = {10.1002/dad2.70468},
  pmid    = {42676462},
  url     = {https://doi.org/10.1002/dad2.70468}
}

@article{zerbinatti2006-17012232,
  author  = {Zerbinatti, C. V. and Wahrle, S. E. and Kim, H. and Cam, J. A. and Bales, K. and Paul, S. M. and Holtzman, D. M. and Bu, G.},
  title   = {{Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m604436200},
  pmid    = {17012232},
  url     = {https://doi.org/10.1074/jbc.m604436200}
}

@article{ulrich2016-26854967,
  author  = {Ulrich, J. D. and Holtzman, D. M.},
  title   = {{TREM2 Function in Alzheimer's Disease and Neurodegeneration}},
  journal = {ACS chemical neuroscience},
  year    = {2016},
  doi     = {10.1021/acschemneuro.5b00313},
  pmid    = {26854967},
  url     = {https://doi.org/10.1021/acschemneuro.5b00313}
}

@article{seo2024-38172602,
  author  = {Seo, D. O. and Holtzman, D. M.},
  title   = {{Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies}},
  journal = {Experimental \& molecular medicine},
  year    = {2024},
  doi     = {10.1038/s12276-023-01146-2},
  pmid    = {38172602},
  url     = {https://doi.org/10.1038/s12276-023-01146-2}
}

@article{musiek2016-27885006,
  author  = {Musiek, E. S. and Holtzman, D. M.},
  title   = {{Mechanisms linking circadian clocks, sleep, and neurodegeneration}},
  journal = {Science (New York, N.Y.)},
  year    = {2016},
  doi     = {10.1126/science.aah4968},
  pmid    = {27885006},
  url     = {https://doi.org/10.1126/science.aah4968}
}

@article{bathini2026-7ec97b6f,
  author  = {Bathini, P. and Schilling, S. and Rahfeld, J. and Holtzman, D. M. and Saido, T. C. and Lemere, C. A.},
  title   = {{Early Binding of Anti-Amyloid Antibodies to CAA Drives Complement Activation, Inflammation and ARIA in Mice}},
  journal = {Molecular neurodegeneration},
  year    = {2026},
  doi     = {10.64898/2026.03.04.709591},
  url     = {https://doi.org/10.64898/2026.03.04.709591}
}

@article{mann2022-35171651,
  author  = {Mann, C. N. and Devi, S. S. and Kersting, C. T. and Bleem, A. V. and Karch, C. M. and Holtzman, D. M. and Gallardo, G.},
  title   = {{Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model}},
  journal = {Science translational medicine},
  year    = {2022},
  doi     = {10.1126/scitranslmed.abm4107},
  pmid    = {35171651},
  url     = {https://doi.org/10.1126/scitranslmed.abm4107}
}

@article{holtzman2016-27154059,
  author  = {Holtzman, D. M. and Carrillo, M. C. and Hendrix, J. A. and Bain, L. J. and Catafau, A. M. and Gault, L. M. and Goedert, M. and Mandelkow, E. and others},
  title   = {{Tau: From research to clinical development}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.03.018},
  pmid    = {27154059},
  url     = {https://doi.org/10.1016/j.jalz.2016.03.018}
}

@article{bales2002-14993413,
  author  = {Bales, K. R. and Dodart, J. C. and DeMattos, R. B. and Holtzman, D. M. and Paul, S. M.},
  title   = {{Apolipoprotein E, amyloid, and Alzheimer disease}},
  journal = {Molecular interventions},
  year    = {2002},
  doi     = {10.1124/mi.2.6.363},
  pmid    = {14993413},
  url     = {https://doi.org/10.1124/mi.2.6.363}
}

@article{holtzman1992-1741393,
  author  = {Holtzman, D. M. and Li, Y. W. and DeArmond, S. J. and McKinley, M. P. and Gage, F. H. and Epstein, C. J. and Mobley, W. C.},
  title   = {{Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.4.1383},
  pmid    = {1741393},
  url     = {https://doi.org/10.1073/pnas.89.4.1383}
}

@article{gallardo2019-32096039,
  author  = {Gallardo, G. and Holtzman, D. M.},
  title   = {{Amyloid-β and Tau at the Crossroads of Alzheimer's Disease}},
  journal = {Advances in experimental medicine and biology},
  year    = {2019},
  doi     = {10.1007/978-981-32-9358-8_16},
  pmid    = {32096039},
  url     = {https://doi.org/10.1007/978-981-32-9358-8_16}
}

@article{wang2020-31408876,
  author  = {Wang, C. and Holtzman, D. M.},
  title   = {{Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2020},
  doi     = {10.1038/s41386-019-0478-5},
  pmid    = {31408876},
  url     = {https://doi.org/10.1038/s41386-019-0478-5}
}

@article{musiek2015-f2cb1175,
  author  = {Musiek, E. S. and Holtzman, D. M.},
  title   = {{Three dimensions of the amyloid hypothesis: time, space and 'wingmen'}},
  journal = {Nature Neuroscience},
  year    = {2015}
}

@article{han2001-11359882,
  author  = {Han, X. and Holtzman, D. M. and McKeel, D. W.},
  title   = {{Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry}},
  journal = {Journal of neurochemistry},
  year    = {2001},
  doi     = {10.1046/j.1471-4159.2001.00332.x},
  pmid    = {11359882},
  url     = {https://doi.org/10.1046/j.1471-4159.2001.00332.x}
}

@article{yuede2009-19524672,
  author  = {Yuede, C. M. and Zimmerman, S. D. and Dong, H. and Kling, M. J. and Bero, A. W. and Holtzman, D. M. and Timson, B. F. and Csernansky, J. G.},
  title   = {{Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2009},
  doi     = {10.1016/j.nbd.2009.06.002},
  pmid    = {19524672},
  url     = {https://doi.org/10.1016/j.nbd.2009.06.002}
}

@article{sun1998-9547235,
  author  = {Sun, Y. and Wu, S. and Bu, G. and Onifade, M. K. and Patel, S. N. and LaDu, M. J. and Fagan, A. M. and Holtzman, D. M.},
  title   = {{Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1998},
  doi     = {10.1523/jneurosci.18-09-03261.1998},
  pmid    = {9547235},
  url     = {https://doi.org/10.1523/jneurosci.18-09-03261.1998}
}

@article{roh2012-22956200,
  author  = {Roh, J. H. and Huang, Y. and Bero, A. W. and Kasten, T. and Stewart, F. R. and Bateman, R. J. and Holtzman, D. M.},
  title   = {{Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology}},
  journal = {Science translational medicine},
  year    = {2012},
  doi     = {10.1126/scitranslmed.3004291},
  pmid    = {22956200},
  url     = {https://doi.org/10.1126/scitranslmed.3004291}
}

@article{shibata2000-11120756,
  author  = {Shibata, M. and Yamada, S. and Kumar, SR. and Calero, M. and Bading, J. and Frangione, B. and Holtzman, D. M. and Miller, C. A. and others},
  title   = {{Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier}},
  journal = {The Journal of clinical investigation},
  year    = {2000},
  doi     = {10.1172/jci10498},
  pmid    = {11120756},
  url     = {https://doi.org/10.1172/jci10498}
}

@article{bell2007-17077814,
  author  = {Bell, R. D. and Sagare, A. P. and Friedman, A. E. and Bedi, G. S. and Holtzman, D. M. and Deane, R. and Zlokovic, B. V.},
  title   = {{Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system}},
  journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year    = {2007},
  doi     = {10.1038/sj.jcbfm.9600419},
  pmid    = {17077814},
  url     = {https://doi.org/10.1038/sj.jcbfm.9600419}
}

@article{funk2015-26126828,
  author  = {Funk, K. E. and Mirbaha, H. and Jiang, H. and Holtzman, D. M. and Diamond, M. I.},
  title   = {{Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.657924},
  pmid    = {26126828},
  url     = {https://doi.org/10.1074/jbc.m115.657924}
}

@article{tarawneh2012-22553492,
  author  = {Tarawneh, R. and Holtzman, D. M.},
  title   = {{The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
  doi     = {10.1101/cshperspect.a006148},
  pmid    = {22553492},
  url     = {https://doi.org/10.1101/cshperspect.a006148}
}