% alzhub.org library filter % Source: https://alzhub.org/research?author=Hardy+J % 32 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{hithersay2019-30452522, author = {Hithersay, R. and Startin, C. M. and Hamburg, S. and Mok, K. Y. and Hardy, J. and Fisher, E. M. C. and Tybulewicz, V. L. J. and Nizetic, D. and others}, title = {{Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2018.3616}, pmid = {30452522}, url = {https://doi.org/10.1001/jamaneurol.2018.3616} } @article{beecham2014-25188341, author = {Beecham, G. W. and Hamilton, K. and Naj, A. C. and Martin, E. R. and Huentelman, M. and Myers, A. J. and Corneveaux, J. J. and Hardy, J. and others}, title = {{Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias}}, journal = {PLoS genetics}, year = {2014}, doi = {10.1371/journal.pgen.1004606}, pmid = {25188341}, url = {https://doi.org/10.1371/journal.pgen.1004606} } @article{strydom2018-29631614, author = {Strydom, A. and Heslegrave, A. and Startin, C. M. and Mok, K. Y. and Hardy, J. and Groet, J. and Nizetic, D. and Zetterberg, H. and others}, title = {{Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome}}, journal = {Alzheimer's research \& therapy}, year = {2018}, doi = {10.1186/s13195-018-0367-x}, pmid = {29631614}, url = {https://doi.org/10.1186/s13195-018-0367-x} } @article{escottprice2017-28727176, author = {Escott-Price, V. and Myers, A. J. and Huentelman, M. and Hardy, J.}, title = {{Polygenic risk score analysis of pathologically confirmed Alzheimer disease}}, journal = {Annals of neurology}, year = {2017}, doi = {10.1002/ana.24999}, pmid = {28727176}, url = {https://doi.org/10.1002/ana.24999} } @article{morgan2000-11140686, author = {Morgan, D. and Diamond, D. M. and Gottschall, P. E. and Ugen, K. E. and Dickey, C. and Hardy, J. and Duff, K. and Jantzen, P. and others}, title = {{A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease}}, journal = {Nature}, year = {2000}, doi = {10.1038/35050116}, pmid = {11140686}, url = {https://doi.org/10.1038/35050116} } @article{rohrer2011-21908872, author = {Rohrer, J. D. and Lashley, T. and Schott, J. M. and Warren, J. E. and Mead, S. and Isaacs, A. M. and Beck, J. and Hardy, J. and others}, title = {{Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration}}, journal = {Brain : a journal of neurology}, year = {2011}, doi = {10.1093/brain/awr198}, pmid = {21908872}, url = {https://doi.org/10.1093/brain/awr198} } @article{reiman2004-14688411, author = {Reiman, E. M. and Chen, K. and Alexander, G. E. and Caselli, R. J. and Bandy, D. and Osborne, D. and Saunders, A. M. and Hardy, J.}, title = {{Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2004}, doi = {10.1073/pnas.2635903100}, pmid = {14688411}, url = {https://doi.org/10.1073/pnas.2635903100} } @article{leonenko2019-31199530, author = {Leonenko, G. and Shoai, M. and Bellou, E. and Sims, R. and Williams, J. and Hardy, J. and Escott-Price, V. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition}}, journal = {Annals of neurology}, year = {2019}, doi = {10.1002/ana.25530}, pmid = {31199530}, url = {https://doi.org/10.1002/ana.25530} } @article{blennow2012-23217738, author = {Blennow, K. and Hardy, J. and Zetterberg, H.}, title = {{The neuropathology and neurobiology of traumatic brain injury}}, journal = {Neuron}, year = {2012}, doi = {10.1016/j.neuron.2012.11.021}, pmid = {23217738}, url = {https://doi.org/10.1016/j.neuron.2012.11.021} } @article{wiseman2015-26243569, author = {Wiseman, F. K. and Al-Janabi, T. and Hardy, J. and Karmiloff-Smith, A. and Nizetic, D. and Tybulewicz, V. L. and Fisher, E. M. and Strydom, A.}, title = {{A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome}}, journal = {Nature reviews. Neuroscience}, year = {2015}, doi = {10.1038/nrn3983}, pmid = {26243569}, url = {https://doi.org/10.1038/nrn3983} } @article{reiman2005-15932949, author = {Reiman, E. M. and Chen, K. and Alexander, G. E. and Caselli, R. J. and Bandy, D. and Osborne, D. and Saunders, A. M. and Hardy, J.}, title = {{Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2005}, doi = {10.1073/pnas.0500579102}, pmid = {15932949}, url = {https://doi.org/10.1073/pnas.0500579102} } @article{forabosco2013-23855984, author = {Forabosco, P. and Ramasamy, A. and Trabzuni, D. and Walker, R. and Smith, C. and Bras, J. and Levine, A. P. and Hardy, J. and others}, title = {{Insights into TREM2 biology by network analysis of human brain gene expression data}}, journal = {Neurobiology of aging}, year = {2013}, doi = {10.1016/j.neurobiolaging.2013.05.001}, pmid = {23855984}, url = {https://doi.org/10.1016/j.neurobiolaging.2013.05.001} } @article{ballard2016-27302127, author = {Ballard, C. and Mobley, W. and Hardy, J. and Williams, G. and Corbett, A.}, title = {{Dementia in Down's syndrome}}, journal = {The Lancet. Neurology}, year = {2016}, doi = {10.1016/s1474-4422(16)00063-6}, pmid = {27302127}, url = {https://doi.org/10.1016/s1474-4422(16)00063-6} } @article{dsouza2020-32986108, author = {D'Souza, H. and Mason, L. and Mok, K. Y. and Startin, C. M. and Hamburg, S. and Hithersay, R. and Baksh, R. A. and Hardy, J. and others}, title = {{Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome}}, journal = {JAMA network open}, year = {2020}, doi = {10.1001/jamanetworkopen.2020.18221}, pmid = {32986108}, url = {https://doi.org/10.1001/jamanetworkopen.2020.18221} } @article{piers2020-31907987, author = {Piers, T. M. and Cosker, K. and Mallach, A. and Johnson, G. T. and Guerreiro, R. and Hardy, J. and Pocock, J. M.}, title = {{A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia}}, journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year = {2020}, doi = {10.1096/fj.201902447r}, pmid = {31907987}, url = {https://doi.org/10.1096/fj.201902447r} } @article{carmona2018-29478590, author = {Carmona, S. and Hardy, J. and Guerreiro, R.}, title = {{The genetic landscape of Alzheimer disease}}, journal = {Handbook of clinical neurology}, year = {2018}, doi = {10.1016/b978-0-444-64076-5.00026-0}, pmid = {29478590}, url = {https://doi.org/10.1016/b978-0-444-64076-5.00026-0} } @article{brownjohn2018-29606617, author = {Brownjohn, P. W. and Smith, J. and Solanki, R. and Lohmann, E. and Houlden, H. and Hardy, J. and Dietmann, S. and Livesey, F. J.}, title = {{Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia}}, journal = {Stem cell reports}, year = {2018}, doi = {10.1016/j.stemcr.2018.03.003}, pmid = {29606617}, url = {https://doi.org/10.1016/j.stemcr.2018.03.003} } @article{ostrerovagolts2000-10934254, author = {Ostrerova-Golts, N. and Petrucelli, L. and Hardy, J. and Lee, J. M. and Farer, M. and Wolozin, B.}, title = {{The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2000}, doi = {10.1523/jneurosci.20-16-06048.2000}, pmid = {10934254}, url = {https://doi.org/10.1523/jneurosci.20-16-06048.2000} } @article{villegasllerena2016-26517285, author = {Villegas-Llerena, C. and Phillips, A. and Garcia-Reitboeck, P. and Hardy, J. and Pocock, J. M.}, title = {{Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease}}, journal = {Current opinion in neurobiology}, year = {2016}, doi = {10.1016/j.conb.2015.10.004}, pmid = {26517285}, url = {https://doi.org/10.1016/j.conb.2015.10.004} } @article{fox1997-9126060, author = {Fox, N. C. and Kennedy, A. M. and Harvey, R. J. and Lantos, P. L. and Roques, P. K. and Collinge, J. and Hardy, J. and Hutton, M. and others}, title = {{Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor}}, journal = {Brain : a journal of neurology}, year = {1997}, doi = {10.1093/brain/120.3.491}, pmid = {9126060}, url = {https://doi.org/10.1093/brain/120.3.491} } @article{guerreiro2015-25679767, author = {Guerreiro, R. and Brás, J. and Hardy, J.}, title = {{SnapShot: Genetics of ALS and FTD}}, journal = {Cell}, year = {2015}, doi = {10.1016/j.cell.2015.01.052}, pmid = {25679767}, url = {https://doi.org/10.1016/j.cell.2015.01.052} } @article{hung2021-34133918, author = {Hung, C. and Tuck, E. and Stubbs, V. and van der Lee, S. J. and Aalfs, C. and van Spaendonk, R. and Scheltens, P. and Hardy, J. and others}, title = {{SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network}}, journal = {Cell reports}, year = {2021}, doi = {10.1016/j.celrep.2021.109259}, pmid = {34133918}, url = {https://doi.org/10.1016/j.celrep.2021.109259} } @article{adhikari2023-36515320, author = {Adhikari, U. K. and Khan, R. and Mikhael, M. and Balez, R. and David, M. A. and Mahns, D. and Hardy, J. and Tayebi, M.}, title = {{Therapeutic anti-amyloid β antibodies cause neuronal disturbances}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.12833}, pmid = {36515320}, url = {https://doi.org/10.1002/alz.12833} } @article{sasaguri2017-28768718, author = {Sasaguri, H. and Nilsson, P. and Hashimoto, S. and Nagata, K. and Saito, T. and De Strooper, B. and Hardy, J. and Vassar, R. and others}, title = {{APP mouse models for Alzheimer's disease preclinical studies}}, journal = {The EMBO journal}, year = {2017}, doi = {10.15252/embj.201797397}, pmid = {28768718}, url = {https://doi.org/10.15252/embj.201797397} } @article{brown1995-8541850, author = {Brown, J. and Ashworth, A. and Gydesen, S. and Sorensen, A. and Rossor, M. and Hardy, J. and Collinge, J.}, title = {{Familial non-specific dementia maps to chromosome 3}}, journal = {Human molecular genetics}, year = {1995}, doi = {10.1093/hmg/4.9.1625}, pmid = {8541850}, url = {https://doi.org/10.1093/hmg/4.9.1625} } @article{raskin2015-26412218, author = {Raskin, J. and Cummings, J. and Hardy, J. and Schuh, K. and Dean, R. A.}, title = {{Neurobiology of Alzheimer's Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions}}, journal = {Current Alzheimer research}, year = {2015}, doi = {10.2174/1567205012666150701103107}, pmid = {26412218}, url = {https://doi.org/10.2174/1567205012666150701103107} } @article{hampel2021-32223911, author = {Hampel, H. and Vassar, R. and De Strooper, B. and Hardy, J. and Willem, M. and Singh, N. and Zhou, J. and Yan, R. and others}, title = {{The β-Secretase BACE1 in Alzheimer's Disease}}, journal = {Biological psychiatry}, year = {2021}, doi = {10.1016/j.biopsych.2020.02.001}, pmid = {32223911}, url = {https://doi.org/10.1016/j.biopsych.2020.02.001} } @article{sofola2010-20824130, author = {Sofola, O. and Kerr, F. and Rogers, I. and Killick, R. and Augustin, H. and Gandy, C. and Allen, M. J. and Hardy, J. and others}, title = {{Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease}}, journal = {PLoS genetics}, year = {2010}, doi = {10.1371/journal.pgen.1001087}, pmid = {20824130}, url = {https://doi.org/10.1371/journal.pgen.1001087} } @article{le2001-11706935, author = {Le, T. V. and Crook, R. and Hardy, J. and Dickson, D. W.}, title = {{Cotton wool plaques in non-familial late-onset Alzheimer disease}}, journal = {Journal of neuropathology and experimental neurology}, year = {2001}, doi = {10.1093/jnen/60.11.1051}, pmid = {11706935}, url = {https://doi.org/10.1093/jnen/60.11.1051} } @article{guerreiro2012-20594621, author = {Guerreiro, R. J. and Gustafson, D. R. and Hardy, J.}, title = {{The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE}}, journal = {Neurobiology of aging}, year = {2012}, doi = {10.1016/j.neurobiolaging.2010.03.025}, pmid = {20594621}, url = {https://doi.org/10.1016/j.neurobiolaging.2010.03.025} } @article{hardy1997-9106355, author = {Hardy, J.}, title = {{Amyloid, the presenilins and Alzheimer's disease}}, journal = {Trends in neurosciences}, year = {1997}, doi = {10.1016/s0166-2236(96)01030-2}, pmid = {9106355}, url = {https://doi.org/10.1016/s0166-2236(96)01030-2} } @article{hardy2014-24749173, author = {Hardy, J. and Bogdanovic, N. and Winblad, B. and Portelius, E. and Andreasen, N. and Cedazo-Minguez, A. and Zetterberg, H.}, title = {{Pathways to Alzheimer's disease}}, journal = {Journal of internal medicine}, year = {2014}, doi = {10.1111/joim.12192}, pmid = {24749173}, url = {https://doi.org/10.1111/joim.12192} }