% alzhub.org library filter
% Source: https://alzhub.org/research?atag=triggering-receptor
% 384 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{koychev2024-39358806,
  author  = {Koychev, Ivan and Reid, Graham and Nguyen, Maggie and Mentz, Robert J and Joyce, Dan and Shah, Svati H and Holman, Rury R},
  title   = {{Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01573-x},
  pmid    = {39358806},
  url     = {https://doi.org/10.1186/s13195-024-01573-x}
}

@article{moussa2017-28086917,
  author  = {Moussa, C. and Hebron, M. and Huang, X. and Ahn, J. and Rissman, R. A. and Aisen, P. S. and Turner, R. S.},
  title   = {{Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2017},
  doi     = {10.1186/s12974-016-0779-0},
  pmid    = {28086917},
  url     = {https://doi.org/10.1186/s12974-016-0779-0}
}

@article{swardfager2010-20692646,
  author  = {Swardfager, W. and Lanctôt, K. and Rothenburg, L. and Wong, A. and Cappell, J. and Herrmann, N.},
  title   = {{A meta-analysis of cytokines in Alzheimer's disease}},
  journal = {Biological psychiatry},
  year    = {2010},
  doi     = {10.1016/j.biopsych.2010.06.012},
  pmid    = {20692646},
  url     = {https://doi.org/10.1016/j.biopsych.2010.06.012}
}

@article{podlesnydrabiniok2020-33127097,
  author  = {Podleśny-Drabiniok, A. and Marcora, E. and Goate, A. M.},
  title   = {{Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics}},
  journal = {Trends in neurosciences},
  year    = {2020},
  doi     = {10.1016/j.tins.2020.10.002},
  pmid    = {33127097},
  url     = {https://doi.org/10.1016/j.tins.2020.10.002}
}

@article{potter2021-33778150,
  author  = {Potter, H. and Woodcock, J. H. and Boyd, T. D. and Coughlan, C. M. and O'Shaughnessy, JR. and Borges, M. T. and Thaker, A. A. and Raj, B. A. and others},
  title   = {{Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12158},
  pmid    = {33778150},
  url     = {https://doi.org/10.1002/trc2.12158}
}

@article{fan2017-28122877,
  author  = {Fan, Z. and Brooks, D. J. and Okello, A. and Edison, P.},
  title   = {{An early and late peak in microglial activation in Alzheimer's disease trajectory}},
  journal = {Brain : a journal of neurology},
  year    = {2017},
  doi     = {10.1093/brain/aww349},
  pmid    = {28122877},
  url     = {https://doi.org/10.1093/brain/aww349}
}

@article{martinsferreira2025-39820004,
  author  = {Martins-Ferreira, Ricardo and Calafell-Segura, Josep and Leal, Bárbara and Rodríguez-Ubreva, Javier and Martínez-Saez, Elena and Mereu, Elisabetta and Costa, Paulo Pinho E and Laguna, Ariadna and others},
  title   = {{The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-56124-1},
  pmid    = {39820004},
  url     = {https://doi.org/10.1038/s41467-025-56124-1}
}

@article{ramanan2015-26268530,
  author  = {Ramanan, Vijay K. and Risacher, Shannon L. and Nho, Kwangsik T. and Kim, Sungeun and Shen, Li and McDonald, Brenna C. and Yoder, Karmen K. and Hutchins, Gary D. and others},
  title   = {{GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP}},
  journal = {Brain},
  year    = {2015},
  doi     = {10.1093/brain/awv231},
  pmid    = {26268530},
  url     = {https://doi.org/10.1093/brain/awv231}
}

@article{amin2022-35314318,
  author  = {Amin, Jay and Erskine, Daniel and Donaghy, Paul C and Surendranathan, Ajenthan and Swann, Peter and Kunicki, Amy P and Boche, Delphine and Holmes, Clive and others},
  title   = {{Inflammation in dementia with Lewy bodies}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105698},
  pmid    = {35314318},
  url     = {https://doi.org/10.1016/j.nbd.2022.105698}
}

@article{holmes2009-19738171,
  author  = {Holmes, C. and Cunningham, C. and Zotova, E. and Woolford, J. and Dean, C. and Kerr, S. and Culliford, D. and Perry, V. H.},
  title   = {{Systemic inflammation and disease progression in Alzheimer disease}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181b6bb95},
  pmid    = {19738171},
  url     = {https://doi.org/10.1212/wnl.0b013e3181b6bb95}
}

@article{vanwetering2024-38715119,
  author  = {van Wetering, Janna and Geut, Hanne and Bol, John J and Galis, Yvon and Timmermans, Evelien and Twisk, Jos W R and Hepp, Dagmar H and Morella, Martino L and others},
  title   = {{Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies}},
  journal = {Acta neuropathologica communications},
  year    = {2024},
  doi     = {10.1186/s40478-024-01786-z},
  pmid    = {38715119},
  url     = {https://doi.org/10.1186/s40478-024-01786-z}
}

@article{diazlucena2021-33881612,
  author  = {Diaz-Lucena, Daniela and Kruse, Niels and Thüne, Katrin and Schmitz, Matthias and Villar-Piqué, Anna and da Cunha, Jose Eriton Gomes and Hermann, Peter and López-Pérez, Óscar and others},
  title   = {{TREM2 expression in the brain and biological fluids in prion diseases}},
  journal = {Acta neuropathologica},
  year    = {2021},
  doi     = {10.1007/s00401-021-02296-1},
  pmid    = {33881612},
  url     = {https://doi.org/10.1007/s00401-021-02296-1}
}

@article{gate2021-34648304,
  author  = {Gate, D. and Tapp, E. and Leventhal, O. and Shahid, M. and Nonninger, T. J. and Yang, A. C. and Strempfl, K. and Unger, M. S. and others},
  title   = {{CD4 + T cells contribute to neurodegeneration in Lewy body dementia}},
  journal = {Science (New York, N.Y.)},
  year    = {2021},
  doi     = {10.1126/science.abf7266},
  pmid    = {34648304},
  url     = {https://doi.org/10.1126/science.abf7266}
}

@article{shi2022-36408515,
  author  = {Shi, Xiaolei and Zhong, Xiaomei and Zhou, Huarong and Zhou, Nan and Hu, Yachun and Ning, Yuping and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum}},
  journal = {Frontiers in neurology},
  year    = {2022},
  doi     = {10.3389/fneur.2022.961842},
  pmid    = {36408515},
  url     = {https://doi.org/10.3389/fneur.2022.961842}
}

@article{feiten2026-41580393,
  author  = {Feiten, Astrid F and Dahm, Kilian and Schlepckow, Kai and van Lengerich, Bettina and Suh, Jung H and Reifschneider, Anika and Wefers, Benedikt and Bartos, Laura M and others},
  title   = {{TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68706-8},
  pmid    = {41580393},
  url     = {https://doi.org/10.1038/s41467-026-68706-8}
}

@article{abdulkhaliq2026-41792456,
  author  = {Abdulkhaliq, Altaf A and Alasiri, Glowi and Kim, Bonglee and Khan, Johra and Ajoolabady, Amir and Yousof, Shimaa Mohammad and Ren, Jun and Tuomilehto, Jaakko and others},
  title   = {{TREM2 in neurodegeneration and diseases}},
  journal = {Molecular psychiatry},
  year    = {2026},
  doi     = {10.1038/s41380-026-03505-7},
  pmid    = {41792456},
  url     = {https://doi.org/10.1038/s41380-026-03505-7}
}

@article{belmontrausch2026-42265098,
  author  = {Belmont-Rausch, Dylan M and Ludwig, Mette Q and Bentsen, Marie A and Hansen, Stine N and Secher, Anna and Holst, Dorte and Moreno, Jaime and Das, Vivek and others},
  title   = {{Semaglutide attenuates neuroinflammation in male mice}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-74038-4},
  pmid    = {42265098},
  url     = {https://doi.org/10.1038/s41467-026-74038-4}
}

@article{ouyang2026-42150695,
  author  = {Ouyang, Xiaoxue and Chia, Rachel S L and Chai, Yuek Ling and Chong, Joyce R and Sim, Ming Ann and Jo, Dong-Gyu and Arumugam, Thiruma V and Sethi, Gautam and others},
  title   = {{Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia}},
  journal = {Biochemical pharmacology},
  year    = {2026},
  doi     = {10.1016/j.bcp.2026.118077},
  pmid    = {42150695},
  url     = {https://doi.org/10.1016/j.bcp.2026.118077}
}

@article{gaire2026-41571675,
  author  = {Gaire, Bhakta Prasad and Koronyo, Yosef and Vit, Jean-Philippe and Hutton, Alexandre and Subedi, Lalita and Fuchs, Dieu-Trang and Swerdlow, Natalie and Rentsendorj, Altan and others},
  title   = {{Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68580-4},
  pmid    = {41571675},
  url     = {https://doi.org/10.1038/s41467-026-68580-4}
}

@article{lee2026-41789727,
  author  = {Lee, Jeongmi and Cho, Yongeun and Choi, Bo Youn and Kim, Hark Kyun and Lee, Yeongyeong and Kim, Eunae and Han, Jihoon and Sul, Jae Hoon and others},
  title   = {{HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag089},
  pmid    = {41789727},
  url     = {https://doi.org/10.1093/brain/awag089}
}

@article{shen2026-42489128,
  author  = {Shen, Qi and Chang, Haocai and Li, Junyu and Guo, Haoyun and Shi, Wenbin and Yan, Yihua and Ouyang, Wenwen and Zhang, Zhan and others},
  title   = {{Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag247},
  pmid    = {42489128},
  url     = {https://doi.org/10.1093/brain/awag247}
}

@article{babicleko2020-32390629,
  author  = {Babić Leko, M. and Nikolac Perković, M. and Klepac, N. and DŠ, Štrac and Borovečki, F. and Pivac, N. and Hof, P. R. and Šimić, G.},
  title   = {{IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer's Disease Pathology}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200056},
  pmid    = {32390629},
  url     = {https://doi.org/10.3233/jad-200056}
}

@article{grubman2021-34021136,
  author  = {Grubman, A. and Choo, X. Y. and Chew, G. and Ouyang, J. F. and Sun, G. and Croft, N. P. and Rossello, F. J. and Simmons, R. and others},
  title   = {{Transcriptional signature in microglia associated with Aβ plaque phagocytosis}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-23111-1},
  pmid    = {34021136},
  url     = {https://doi.org/10.1038/s41467-021-23111-1}
}

@article{deschepper2023-36747024,
  author  = {De Schepper, S. and Ge, J. Z. and Sierksma, A. and Crowley, G. and Ferreira, L. S. S. and Garceau, D. and Toomey, C. E. and Sokolova, D. and others},
  title   = {{Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease}},
  journal = {Nature neuroscience},
  year    = {2023},
  doi     = {10.1038/s41593-023-01257-z},
  pmid    = {36747024},
  url     = {https://doi.org/10.1038/s41593-023-01257-z}
}

@article{wendeln2018-29643512,
  author  = {Wendeln, A. C. and Degenhardt, K. and Kaurani, L. and Gertig, M. and Ulas, T. and Jain, G. and Wagner, J. and Häsler, L. M. and others},
  title   = {{Innate immune memory in the brain shapes neurological disease hallmarks}},
  journal = {Nature},
  year    = {2018},
  doi     = {10.1038/s41586-018-0023-4},
  pmid    = {29643512},
  url     = {https://doi.org/10.1038/s41586-018-0023-4}
}

@article{jakimovski2024-37949093,
  author  = {Jakimovski, D. and Bittner, S. and Zivadinov, R. and Morrow, S. A. and Benedict, R. H. and Zipp, F. and Weinstock-Guttman, B.},
  title   = {{Multiple sclerosis}},
  journal = {Lancet (London, England)},
  year    = {2024},
  doi     = {10.1016/s0140-6736(23)01473-3},
  pmid    = {37949093},
  url     = {https://doi.org/10.1016/s0140-6736(23)01473-3}
}

@article{schott2013-23983027,
  author  = {Schott, Jonathan M. and Révész, Tamás},
  title   = {{Inflammation in Alzheimer’s disease: insights from immunotherapy}},
  journal = {Brain},
  year    = {2013},
  doi     = {10.1093/brain/awt231},
  pmid    = {23983027},
  url     = {https://doi.org/10.1093/brain/awt231}
}

@article{jin2025-40801241,
  author  = {Jin, Zhihui and Lu, Yan and Tang, Huifang and Cui, Huashun},
  title   = {{Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non-human primate models}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70472},
  pmid    = {40801241},
  url     = {https://doi.org/10.1002/alz.70472}
}

@article{hovde2025-41216966,
  author  = {Hovde, Moriah J and Maaser-Hecker, Anna and Bae, Jun-Seok and Tanzi, Rudolph E},
  title   = {{Inhibition of Acyl-CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low-density lipoprotein receptor 1 (LRP1)-dependent phagocytosis of amyloid beta protein in microglia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70879},
  pmid    = {41216966},
  url     = {https://doi.org/10.1002/alz.70879}
}

@article{dean2024-39032157,
  author  = {Dean, Hunter B and Greer, Rory A and Yang, Shan-Zhong and Elston, Daniel S and Brett, Thomas J and Roberson, Erik D and Song, Yuhua},
  title   = {{Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14124},
  pmid    = {39032157},
  url     = {https://doi.org/10.1002/alz.14124}
}

@article{danhash2025-40843775,
  author  = {Danhash, Emma P and Verbeck, Anthony C and Western, Daniel and Díaz-Pacheco, Andrea S and Galasso, Grant and You, Shih-Feng and Huang, Guangming and Starr, Emma and others},
  title   = {{Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70580},
  pmid    = {40843775},
  url     = {https://doi.org/10.1002/alz.70580}
}

@article{messenger2025-40346446,
  author  = {Messenger, Evan J and Baar, Sydney A and Bedford, Logan M and Tsai, Andy P and Lin, Peter Bor-Chian and Ferguson, Chloe A and Xu, Guixiang and Wallace, Abigail and others},
  title   = {{PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70231},
  pmid    = {40346446},
  url     = {https://doi.org/10.1002/alz.70231}
}

@article{gomez2025-40490625,
  author  = {Gomez, Andrew R and Byun, Hyae Ran and Wu, Shaogen and Muhammad, A K M Ghulam and Ikbariyeh, Jasmine and Chen, Jaelin and Muro, Alek and Li, Lin and others},
  title   = {{Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice}},
  journal = {Nature aging},
  year    = {2025},
  doi     = {10.1038/s43587-025-00879-1},
  pmid    = {40490625},
  url     = {https://doi.org/10.1038/s43587-025-00879-1}
}

@article{bedford2025-41066163,
  author  = {Bedford, Logan M and Tutrow, Kaylee D and Hooper, Karly and Messenger, Evan J and Hernandez, Melody and Lamb, Bruce T and Meyer, Jason S and Richardson, Timothy I and others},
  title   = {{Alzheimer's disease-associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell-derived microglia-like cells}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70772},
  pmid    = {41066163},
  url     = {https://doi.org/10.1002/alz.70772}
}

@article{schauer2024-39090679,
  author  = {Schauer, Stephen P and Cho, Chang Hoon and Novikova, Gloriia and Roth, Gillie A and Lee, Julie and Sharma, Anup D and Foley, Alejandro R and Ng, Carl and others},
  title   = {{Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13921},
  pmid    = {39090679},
  url     = {https://doi.org/10.1002/alz.13921}
}

@article{hartmann2024-38528004,
  author  = {Hartmann, Jakob and Bajaj, Thomas and Otten, Joy and Klengel, Claudia and Ebert, Tim and Gellner, Anne-Kathrin and Junglas, Ellen and Hafner, Kathrin and others},
  title   = {{SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-46953-x},
  pmid    = {38528004},
  url     = {https://doi.org/10.1038/s41467-024-46953-x}
}

@article{riversauty2024-39229486,
  author  = {Rivers-Auty, Jack and Hoyle, Christopher and Pointer, Ayesha and Lawrence, Catherine and Pickering-Brown, Stuart and Brough, David and Ryan, Sarah},
  title   = {{C9orf72 dipeptides activate the NLRP3 inflammasome}},
  journal = {Brain communications},
  year    = {2024},
  doi     = {10.1093/braincomms/fcae282},
  pmid    = {39229486},
  url     = {https://doi.org/10.1093/braincomms/fcae282}
}

@article{mancuso2019-31504240,
  author  = {Mancuso, R. and Fryatt, G. and Cleal, M. and Obst, J. and Pipi, E. and Monzón-Sandoval, J. and Ribe, E. and Winchester, L. and others},
  title   = {{CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice}},
  journal = {Brain : a journal of neurology},
  year    = {2019},
  doi     = {10.1093/brain/awz241},
  pmid    = {31504240},
  url     = {https://doi.org/10.1093/brain/awz241}
}

@article{olah2018-29416036,
  author  = {Olah, M. and Patrick, E. and Villani, A. C. and Xu, J. and White, C. C. and Ryan, K. J. and Piehowski, P. and Kapasi, A. and others},
  title   = {{A transcriptomic atlas of aged human microglia}},
  journal = {Nature communications},
  year    = {2018},
  doi     = {10.1038/s41467-018-02926-5},
  pmid    = {29416036},
  url     = {https://doi.org/10.1038/s41467-018-02926-5}
}

@article{demiguel2021-34880498,
  author  = {De Miguel, Z. and Khoury, N. and Betley, M. J. and Lehallier, B. and Willoughby, D. and Olsson, N. and Yang, A. C. and Hahn, O. and others},
  title   = {{Exercise plasma boosts memory and dampens brain inflammation via clusterin}},
  journal = {Nature},
  year    = {2021},
  doi     = {10.1038/s41586-021-04183-x},
  pmid    = {34880498},
  url     = {https://doi.org/10.1038/s41586-021-04183-x}
}

@article{spangenberg2019-31434879,
  author  = {Spangenberg, E. and Severson, P. L. and Hohsfield, L. A. and Crapser, J. and Zhang, J. and Burton, E. A. and Zhang, Y. and Spevak, W. and others},
  title   = {{Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model}},
  journal = {Nature communications},
  year    = {2019},
  doi     = {10.1038/s41467-019-11674-z},
  pmid    = {31434879},
  url     = {https://doi.org/10.1038/s41467-019-11674-z}
}

@article{minhas2021-33473210,
  author  = {Minhas, P. S. and Latif-Hernandez, A. and McReynolds, M. R. and Durairaj, A. S. and Wang, Q. and Rubin, A. and Joshi, A. U. and He, J. Q. and others},
  title   = {{Restoring metabolism of myeloid cells reverses cognitive decline in ageing}},
  journal = {Nature},
  year    = {2021},
  doi     = {10.1038/s41586-020-03160-0},
  pmid    = {33473210},
  url     = {https://doi.org/10.1038/s41586-020-03160-0}
}

@article{kloske2023-36975090,
  author  = {Kloske, Courtney M and Barnum, Christopher J and Batista, Andre F and Bradshaw, Elizabeth M and Brickman, Adam M and Bu, Guojun and Dennison, Jessica and Gearon, Mary D and others},
  title   = {{APOE and immunity: Research highlights}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.13020},
  pmid    = {36975090},
  url     = {https://doi.org/10.1002/alz.13020}
}

@article{rosner2026-41435829,
  author  = {Rosner, Dalya and Sun, Jiahong and Cacace, Rita and Yee, Angie and Wagh, Chaitanya and Rychkova, Anna and Dunlap, Mariah and Gulbranson, Daniel and others},
  title   = {{The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states}},
  journal = {Neuron},
  year    = {2026},
  doi     = {10.1016/j.neuron.2025.11.022},
  pmid    = {41435829},
  url     = {https://doi.org/10.1016/j.neuron.2025.11.022}
}

@article{lv2026-42865133,
  author  = {Lv, Yaqing and Shi, Mingpeng and Zhao, Yongfei and Yu, Yi and Lv, Jiawei and Zhao, Hai},
  title   = {{Context-dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer}},
  journal = {Clinical and translational medicine},
  year    = {2026},
  doi     = {10.1002/ctm2.70863},
  pmid    = {42865133},
  url     = {https://doi.org/10.1002/ctm2.70863}
}

@article{abdulkhaliq2026-41213496,
  author  = {Abdulkhaliq, Altaf A and Alasiri, Glowi and Almoghrabi, Yousef and Kim, Bonglee and Khan, Johra and Ajoolabady, Amir and Ren, Jun and Tuomilehto, Jaakko and others},
  title   = {{Role of TREM2 in neuroinflammation}},
  journal = {Experimental neurology},
  year    = {2026},
  doi     = {10.1016/j.expneurol.2025.115547},
  pmid    = {41213496},
  url     = {https://doi.org/10.1016/j.expneurol.2025.115547}
}

@article{mallach2021-34704019,
  author  = {Mallach, Anna and Gobom, Johan and Zetterberg, Henrik and Hardy, John and Piers, Thomas M and Wray, Selina and Pocock, Jennifer M},
  title   = {{The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles}},
  journal = {Brain communications},
  year    = {2021},
  doi     = {10.1093/braincomms/fcab009},
  pmid    = {34704019},
  url     = {https://doi.org/10.1093/braincomms/fcab009}
}

@article{konstantoulea2026-41770935,
  author  = {Konstantoulea, Katerina and Ramakers, Meine and Borrie, Sarah C and T'Syen, Dries and Moechars, Daan and Sliwinska, Malgorzata A and Pradhan, Brajabandhu and Albertini, Giulia and others},
  title   = {{Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2026},
  doi     = {10.1073/pnas.2516774123},
  pmid    = {41770935},
  url     = {https://doi.org/10.1073/pnas.2516774123}
}

@article{moonen2023-36481964,
  author  = {Moonen, Sebastiaan and Koper, Marta J and Van Schoor, Evelien and Schaeverbeke, Jolien M and Vandenberghe, Rik and von Arnim, Christine A F and Tousseyn, Thomas and De Strooper, Bart and others},
  title   = {{Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons}},
  journal = {Acta neuropathologica},
  year    = {2023},
  doi     = {10.1007/s00401-022-02528-y},
  pmid    = {36481964},
  url     = {https://doi.org/10.1007/s00401-022-02528-y}
}

@article{zeenny2026-42377782,
  author  = {Zeenny, Marie-Noel and Salame, Ingrid and Maatouk, Lynn and Akoury, Elias},
  title   = {{Neuroinflammation and Tauopathies}},
  journal = {Molecular biology reports},
  year    = {2026},
  doi     = {10.1007/s11033-026-12253-4},
  pmid    = {42377782},
  url     = {https://doi.org/10.1007/s11033-026-12253-4}
}

@article{chou2023-38016942,
  author  = {Chou, Vicky and Pearse, Richard V and Aylward, Aimee J and Ashour, Nancy and Taga, Mariko and Terzioglu, Gizem and Fujita, Masashi and Fancher, Seeley B and others},
  title   = {{INPP5D regulates inflammasome activation in human microglia}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-42819-w},
  pmid    = {38016942},
  url     = {https://doi.org/10.1038/s41467-023-42819-w}
}

@article{lopezrodriguez2021-34080771,
  author  = {Lopez-Rodriguez, Ana Belen and Hennessy, Edel and Murray, Carol L and Nazmi, Arshed and Delaney, Hugh J and Healy, Dáire and Fagan, Steven G and Rooney, Michael and others},
  title   = {{Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12341},
  pmid    = {34080771},
  url     = {https://doi.org/10.1002/alz.12341}
}

@article{kim2026-41673711,
  author  = {Kim, Yeji and Ha, Tae-Young and Kondaurova, Oksana and Lee, Myung-Shik and Chang, Keun-A},
  title   = {{Microglia TFEB activation attenuates Alzheimer's disease pathology by enhancing autophagy-lysosomal function}},
  journal = {Journal of neuroinflammation},
  year    = {2026},
  doi     = {10.1186/s12974-026-03728-z},
  pmid    = {41673711},
  url     = {https://doi.org/10.1186/s12974-026-03728-z}
}

@article{chen2023-36835494,
  author  = {Chen, Yi-Chun and Chang, Shih-Cheng and Lee, Yun-Shien and Ho, Wei-Min and Huang, Yu-Hua and Wu, Yah-Yuan and Chu, Yi-Chuan and Wu, Kuan-Hsuan and others},
  title   = {{TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24044085},
  pmid    = {36835494},
  url     = {https://doi.org/10.3390/ijms24044085}
}

@article{kim2021-33382892,
  author  = {Kim, Jong-Heon and Afridi, Ruqayya and Han, Jin and Jung, Hyun-Gug and Kim, Seung-Chan and Hwang, Eun Mi and Shim, Hyun Soo and Ryu, Hoon and others},
  title   = {{Gamma subunit of complement component 8 is a neuroinflammation inhibitor}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awaa425},
  pmid    = {33382892},
  url     = {https://doi.org/10.1093/brain/awaa425}
}

@article{yao2023-37670126,
  author  = {Yao, Jing and Wang, Zhe and Song, Weihong and Zhang, Yun},
  title   = {{Targeting NLRP3 inflammasome for neurodegenerative disorders}},
  journal = {Molecular psychiatry},
  year    = {2023},
  doi     = {10.1038/s41380-023-02239-0},
  pmid    = {37670126},
  url     = {https://doi.org/10.1038/s41380-023-02239-0}
}

@article{li2026-41734021,
  author  = {Li, Tao and Castro-Gomez, Sergio and Lucena, Pablo Botella and Vieira-Saecker, Ana and Schwartz, Stephanie and Ding, Yingying and Deng, Yushuang and Gou, Maling and others},
  title   = {{Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model}},
  journal = {The Journal of clinical investigation},
  year    = {2026},
  doi     = {10.1172/jci199818},
  pmid    = {41734021},
  url     = {https://doi.org/10.1172/jci199818}
}

@article{jantti2022-35706029,
  author  = {Jäntti, H. and Sitnikova, V. and Ishchenko, Y. and Shakirzyanova, A. and Giudice, L. and Ugidos, I. F. and Gómez-Budia, M. and Korvenlaita, N. and others},
  title   = {{Microglial amyloid beta clearance is driven by PIEZO1 channels}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02486-y},
  pmid    = {35706029},
  url     = {https://doi.org/10.1186/s12974-022-02486-y}
}

@article{venegas2017-29293211,
  author  = {Venegas, C. and Kumar, S. and Franklin, B. S. and Dierkes, T. and Brinkschulte, R. and Tejera, D. and Vieira-Saecker, A. and Schwartz, S. and others},
  title   = {{Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease}},
  journal = {Nature},
  year    = {2017},
  doi     = {10.1038/nature25158},
  pmid    = {29293211},
  url     = {https://doi.org/10.1038/nature25158}
}

@article{muzio2021-34630027,
  author  = {Muzio, L. and Viotti, A. and Martino, G.},
  title   = {{Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy}},
  journal = {Frontiers in neuroscience},
  year    = {2021},
  doi     = {10.3389/fnins.2021.742065},
  pmid    = {34630027},
  url     = {https://doi.org/10.3389/fnins.2021.742065}
}

@article{wendimu2022-35805174,
  author  = {Wendimu, M. Y. and Hooks, S. B.},
  title   = {{Microglia Phenotypes in Aging and Neurodegenerative Diseases}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11132091},
  pmid    = {35805174},
  url     = {https://doi.org/10.3390/cells11132091}
}

@article{lier2021-34571885,
  author  = {Lier, J. and Streit, W. J. and Bechmann, I.},
  title   = {{Beyond Activation: Characterizing Microglial Functional Phenotypes}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10092236},
  pmid    = {34571885},
  url     = {https://doi.org/10.3390/cells10092236}
}

@article{cornell2022-34472455,
  author  = {Cornell, J. and Salinas, S. and Huang, H. Y. and Zhou, M.},
  title   = {{Microglia regulation of synaptic plasticity and learning and memory}},
  journal = {Neural regeneration research},
  year    = {2022},
  doi     = {10.4103/1673-5374.322423},
  pmid    = {34472455},
  url     = {https://doi.org/10.4103/1673-5374.322423}
}

@article{xie2021-35069578,
  author  = {Xie, J. and Van Hoecke, L. and Vandenbroucke, R. E.},
  title   = {{The Impact of Systemic Inflammation on Alzheimer's Disease Pathology}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.796867},
  pmid    = {35069578},
  url     = {https://doi.org/10.3389/fimmu.2021.796867}
}

@article{daniels2016-27509875,
  author  = {Daniels, M. J. and Rivers-Auty, J. and Schilling, T. and Spencer, N. G. and Watremez, W. and Fasolino, V. and Booth, S. J. and White, C. S. and others},
  title   = {{Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models}},
  journal = {Nature communications},
  year    = {2016},
  doi     = {10.1038/ncomms12504},
  pmid    = {27509875},
  url     = {https://doi.org/10.1038/ncomms12504}
}

@article{salter2017-28886007,
  author  = {Salter, M. W. and Stevens, B.},
  title   = {{Microglia emerge as central players in brain disease}},
  journal = {Nature medicine},
  year    = {2017},
  doi     = {10.1038/nm.4397},
  pmid    = {28886007},
  url     = {https://doi.org/10.1038/nm.4397}
}

@article{zhang2023-37433768,
  author  = {Zhang, W. and Xiao, D. and Mao, Q. and Xia, H.},
  title   = {{Role of neuroinflammation in neurodegeneration development}},
  journal = {Signal transduction and targeted therapy},
  year    = {2023},
  doi     = {10.1038/s41392-023-01486-5},
  pmid    = {37433768},
  url     = {https://doi.org/10.1038/s41392-023-01486-5}
}

@article{guo2022-35250543,
  author  = {Guo, S. and Wang, H. and Yin, Y.},
  title   = {{Microglia Polarization From M1 to M2 in Neurodegenerative Diseases}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.815347},
  pmid    = {35250543},
  url     = {https://doi.org/10.3389/fnagi.2022.815347}
}

@article{rajesh2022-35741014,
  author  = {Rajesh, Y. and Kanneganti, T. D.},
  title   = {{Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11121885},
  pmid    = {35741014},
  url     = {https://doi.org/10.3390/cells11121885}
}

@article{yang2022-36353359,
  author  = {Yang, J. and Ran, M. and Li, H. and Lin, Y. and Ma, K. and Yang, Y. and Fu, X. and Yang, S.},
  title   = {{New insight into neurological degeneration: Inflammatory cytokines and blood-brain barrier}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2022},
  doi     = {10.3389/fnmol.2022.1013933},
  pmid    = {36353359},
  url     = {https://doi.org/10.3389/fnmol.2022.1013933}
}

@article{qi2025-41168805,
  author  = {Qi, Xiaoshan and Zhu, Kedong and Ke, Wei and Wang, Junjie and Mao, Shanping and Chen, Guiqin},
  title   = {{Roles of TREM2 in Alzheimer's disease}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00515-3},
  pmid    = {41168805},
  url     = {https://doi.org/10.1186/s40035-025-00515-3}
}

@article{peng2025-41261263,
  author  = {Peng, Xiao-Qian and Yang, Zi-Kang and Guo, Hong-Song and Wu, Xiang-Yuan and Ruganzu, John Bosco and Liu, Zhong-Zhong and Wu, Song-Di and Yang, Wei-Na},
  title   = {{TREM2 Alleviates Neuroinflammation and Improves Neurogenesis in ApoE-/- Mice by Regulating M1/M2 Microglial Polarization}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-05449-5},
  pmid    = {41261263},
  url     = {https://doi.org/10.1007/s12035-025-05449-5}
}

@article{olejnik2025-40405515,
  author  = {Olejnik, Beata and Ferens-Sieczkowska, Mirosława},
  title   = {{Lectins and neurodegeneration: A glycobiologist's perspective}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2025},
  doi     = {10.17219/acem/204107},
  pmid    = {40405515},
  url     = {https://doi.org/10.17219/acem/204107}
}

@article{shojaei2024-39431020,
  author  = {Shojaei, Monireh and Schaefer, Rebecca and Schlepckow, Kai and Kunze, Lea H and Struebing, Felix L and Brunner, Bettina and Willem, Michael and Bartos, Laura M and others},
  title   = {{PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies}},
  journal = {Theranostics},
  year    = {2024},
  doi     = {10.7150/thno.97149},
  pmid    = {39431020},
  url     = {https://doi.org/10.7150/thno.97149}
}

@article{bosco2025-39353548,
  author  = {Bosco, Dale B and Kremen, Vaclav and Haruwaka, Koichiro and Zhao, Shunyi and Wang, Lingxiao and Ebner, Blake A and Zheng, Jiaying and Xie, Manling and others},
  title   = {{Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus}},
  journal = {Brain, behavior, and immunity},
  year    = {2025},
  doi     = {10.1016/j.bbi.2024.09.034},
  pmid    = {39353548},
  url     = {https://doi.org/10.1016/j.bbi.2024.09.034}
}

@article{chen2025-40305572,
  author  = {Chen, Dadian and Wang, Chen and Chen, Xi and Li, Jiayu and Chen, Shuai and Li, Yanzhong and Ma, Fangling and Li, Tingting and others},
  title   = {{Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders}},
  journal = {Science translational medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.ads6111},
  pmid    = {40305572},
  url     = {https://doi.org/10.1126/scitranslmed.ads6111}
}

@article{chiang2024-38592304,
  author  = {Chiang, Yi-Kuan and Lin, Yung-Shuan and Chen, Chun-Yu and Lirng, Jiing-Feng and Yang, Yu-Hsiu and Lee, Wei-Ju and Fuh, Jong-Ling},
  title   = {{Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2024},
  doi     = {10.1177/15333175241243183},
  pmid    = {38592304},
  url     = {https://doi.org/10.1177/15333175241243183}
}

@article{cho2025-41337883,
  author  = {Cho, Sungwoo and El Gaamouch, Farida and Upadhyay, Saurabh and Nada, Hossam and Kuncewicz, Katarzyna and Gabr, Moustafa T},
  title   = {{As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2025},
  doi     = {10.1016/j.biopha.2025.118862},
  pmid    = {41337883},
  url     = {https://doi.org/10.1016/j.biopha.2025.118862}
}

@article{gallo2025-41390810,
  author  = {Gallo, Carmela and Verrillo, Lucia and Manzo, Emiliano and Cauzzi, Emma and La Barbera, Livia and Sabatino, Giuseppina and De Paolis, Maria Luisa and Sciacca, Michele Francesco Maria and others},
  title   = {{Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03634-w},
  pmid    = {41390810},
  url     = {https://doi.org/10.1186/s12974-025-03634-w}
}

@article{ramakrishnan2024-38613944,
  author  = {Ramakrishnan, Gautham S and Berry, William L and Pacherille, Angela and Kerr, William G and Chisholm, John D and Pedicone, Chiara and Humphrey, Mary Beth},
  title   = {{SHIP inhibition mediates select TREM2-induced microglial functions}},
  journal = {Molecular immunology},
  year    = {2024},
  doi     = {10.1016/j.molimm.2024.04.002},
  pmid    = {38613944},
  url     = {https://doi.org/10.1016/j.molimm.2024.04.002}
}

@article{ferri2020-33768114,
  author  = {Ferri, Evelyn and Rossi, Paolo Dionigi and Geraci, Annalisa and Ciccone, Simona and Cesari, Matteo and Arosio, Beatrice},
  title   = {{The sTREM2 Concentrations in the Blood: A Marker of Neurodegeneration?}},
  journal = {Frontiers in molecular biosciences},
  year    = {2020},
  doi     = {10.3389/fmolb.2020.627931},
  pmid    = {33768114},
  url     = {https://doi.org/10.3389/fmolb.2020.627931}
}

@article{njoku2025-41009633,
  author  = {Njoku, George Chigozie and Kanmogne, Georgette Djuidje},
  title   = {{Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer's Disease and HIV-Associated Neurocognitive Disorders}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26189069},
  pmid    = {41009633},
  url     = {https://doi.org/10.3390/ijms26189069}
}

@article{yin2024-38347225,
  author  = {Yin, Tao and Yesiltepe, Metin and D'Adamio, Luciano},
  title   = {{Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias}},
  journal = {EMBO reports},
  year    = {2024},
  doi     = {10.1038/s44319-024-00077-x},
  pmid    = {38347225},
  url     = {https://doi.org/10.1038/s44319-024-00077-x}
}

@article{chen2025-40122810,
  author  = {Chen, Kai and Li, Fuyao and Zhang, Shuwen and Chen, Yixing and Ikezu, Tadafumi C and Li, Zonghua and Martens, Yuka A and Qiao, Wenhui and others},
  title   = {{Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03420-8},
  pmid    = {40122810},
  url     = {https://doi.org/10.1186/s12974-025-03420-8}
}

@article{li2025-40940798,
  author  = {Li, Ling and Zheng, Xiaoxiao and Ma, Hongyue and Zhu, Mingxia and Li, Xiuli and Sun, Xiaodan and Feng, Xinhong},
  title   = {{TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14171387},
  pmid    = {40940798},
  url     = {https://doi.org/10.3390/cells14171387}
}

@article{zgorzynska2024-38244651,
  author  = {Zgorzynska, Emilia},
  title   = {{TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges}},
  journal = {Molecular and cellular neurosciences},
  year    = {2024},
  doi     = {10.1016/j.mcn.2024.103917},
  pmid    = {38244651},
  url     = {https://doi.org/10.1016/j.mcn.2024.103917}
}

@article{wang2024-38831312,
  author  = {Wang, Xueting and Xie, Yuqi and Fan, Xiaoyang and Wu, Xiaomei and Wang, Dan and Zhu, Li},
  title   = {{Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01489-6},
  pmid    = {38831312},
  url     = {https://doi.org/10.1186/s13195-024-01489-6}
}

@article{vandermeulen2024-38654375,
  author  = {Vandermeulen, Lina and Geric, Ivana and Fumagalli, Laura and Kreir, Mohamed and Lu, Ashley and Nonneman, Annelies and Premereur, Jessie and Wolfs, Leen and others},
  title   = {{Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-024-00725-9},
  pmid    = {38654375},
  url     = {https://doi.org/10.1186/s13024-024-00725-9}
}

@article{sun2024-39062547,
  author  = {Sun, Zhongqing and Zhang, Xin and So, Kwok-Fai and Jiang, Wen and Chiu, Kin},
  title   = {{Targeting Microglia in Alzheimer's Disease: Pathogenesis and Potential Therapeutic Strategies}},
  journal = {Biomolecules},
  year    = {2024},
  doi     = {10.3390/biom14070833},
  pmid    = {39062547},
  url     = {https://doi.org/10.3390/biom14070833}
}

@article{aldalahmah2024-38626772,
  author  = {Al-Dalahmah, Osama and Lam, Matti and McInvale, Julie J and Qu, Wenhui and Nguyen, Trang and Mun, Jeong-Yeon and Kwon, Sam and Ifediora, Nkechime and others},
  title   = {{Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons}},
  journal = {Cell stem cell},
  year    = {2024},
  doi     = {10.1016/j.stem.2024.03.013},
  pmid    = {38626772},
  url     = {https://doi.org/10.1016/j.stem.2024.03.013}
}

@article{cadiz2024-38226975,
  author  = {Cadiz, Mika P and Gibson, Katelin A and Todd, Kennedi T and Nascari, David G and Massa, Nashali and Lilley, Meredith T and Olney, Kimberly C and Al-Amin, Md Mamun and others},
  title   = {{Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231363},
  pmid    = {38226975},
  url     = {https://doi.org/10.1084/jem.20231363}
}

@article{butovsky2025-40324382,
  author  = {Butovsky, Oleg and Rosenzweig, Neta},
  title   = {{Alzheimer's disease and age-related macular degeneration: Shared and distinct immune mechanisms}},
  journal = {Immunity},
  year    = {2025},
  doi     = {10.1016/j.immuni.2025.04.013},
  pmid    = {40324382},
  url     = {https://doi.org/10.1016/j.immuni.2025.04.013}
}

@article{xu2025-40075143,
  author  = {Xu, Wen and Huang, Yi and Zhou, Rongbin},
  title   = {{NLRP3 inflammasome in neuroinflammation and central nervous system diseases}},
  journal = {Cellular \& molecular immunology},
  year    = {2025},
  doi     = {10.1038/s41423-025-01275-w},
  pmid    = {40075143},
  url     = {https://doi.org/10.1038/s41423-025-01275-w}
}

@article{li2025-40260242,
  author  = {Li, Zhitao and Gong, Chunrong},
  title   = {{NLRP3 inflammasome in Alzheimer's disease: molecular mechanisms and emerging therapies}},
  journal = {Frontiers in immunology},
  year    = {2025},
  doi     = {10.3389/fimmu.2025.1583886},
  pmid    = {40260242},
  url     = {https://doi.org/10.3389/fimmu.2025.1583886}
}

@article{verma2024-38507186,
  author  = {Verma, Ambika and Azhar, Gohar and Patyal, Pankaj and Zhang, Wei and Zhang, Xiaomin and Wei, Jeanne Y},
  title   = {{Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells}},
  journal = {GeroScience},
  year    = {2024},
  doi     = {10.1007/s11357-024-01117-z},
  pmid    = {38507186},
  url     = {https://doi.org/10.1007/s11357-024-01117-z}
}

@article{wang2025-40847374,
  author  = {Wang, Jie and Ni, Hong and Wang, Yu and Wei, Luyao and Ding, Hanqing and Guo, Zhongzhao and Pan, Hao and Yu, Ying and others},
  title   = {{Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00501-9},
  pmid    = {40847374},
  url     = {https://doi.org/10.1186/s40035-025-00501-9}
}

@article{guo2025-40541122,
  author  = {Guo, Minsong and Wang, Zhengqin and Zhou, Xiaogang and Yu, Chonglin and Wu, Jianming and Yu, Lu and Mi, Jianing and Ren, Fang and others},
  title   = {{Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.156928},
  pmid    = {40541122},
  url     = {https://doi.org/10.1016/j.phymed.2025.156928}
}

@article{vilella2024-37967665,
  author  = {Vilella, Antonietta and Bodria, Martina and Papotti, Bianca and Zanotti, Ilaria and Zimetti, Francesca and Remaggi, Giulia and Elviri, Lisa and Potì, Francesco and others},
  title   = {{PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2024},
  doi     = {10.1016/j.bbi.2023.11.008},
  pmid    = {37967665},
  url     = {https://doi.org/10.1016/j.bbi.2023.11.008}
}

@article{xu2025-41175591,
  author  = {Xu, Ziwei and Huang, Feijun and Wu, Zheming and Xu, Ke and Huang, Liping},
  title   = {{Syringin attenuates Alzheimer's disease-associated neuroinflammation by inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.157454},
  pmid    = {41175591},
  url     = {https://doi.org/10.1016/j.phymed.2025.157454}
}

@article{joshi2024-39215356,
  author  = {Joshi, Radhika and Brezani, Veronika and Mey, Gabrielle M and Guixé-Muntet, Sergi and Ortega-Ribera, Marti and Zhuang, Yuan and Zivny, Adam and Werneburg, Sebastian and others},
  title   = {{IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2024},
  doi     = {10.1186/s12974-024-03203-7},
  pmid    = {39215356},
  url     = {https://doi.org/10.1186/s12974-024-03203-7}
}

@article{li2024-38043010,
  author  = {Li, Yunfeng and Chen, Xiongjin and Zhou, Mulan and Feng, Sifan and Peng, Xiaoping and Wang, Yan},
  title   = {{Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-230273},
  pmid    = {38043010},
  url     = {https://doi.org/10.3233/jad-230273}
}

@article{ravichandran2025-41206011,
  author  = {Ravichandran, Kishore Aravind and Brosseron, Frederic and McManus, Róisín M and Ising, Christina and Görgen, Simon and Schmidt, Susanne V and Santarelli, Fracesco and Lee, Se Young and others},
  title   = {{Enhancing Tyro3 signaling ameliorates IL-1β production through STAT1 in Alzheimer's disease models}},
  journal = {Journal of leukocyte biology},
  year    = {2025},
  doi     = {10.1093/jleuko/qiaf157},
  pmid    = {41206011},
  url     = {https://doi.org/10.1093/jleuko/qiaf157}
}

@article{han2025-40400619,
  author  = {Han, Jialin and Zhang, Zhi and Zhang, Pengfei and Yu, Qian and Cheng, Qian and Lu, Zhiming and Zong, Shuai},
  title   = {{The roles of microglia and astrocytes in neuroinflammation of Alzheimer's disease}},
  journal = {Frontiers in neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1575453},
  pmid    = {40400619},
  url     = {https://doi.org/10.3389/fnins.2025.1575453}
}

@article{serradas2024-39272998,
  author  = {Serradas, Maria L and Ding, Yingying and Martorell, Paula V and Kulińska, Ida and Castro-Gomez, Sergio},
  title   = {{Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease}},
  journal = {Cells},
  year    = {2024},
  doi     = {10.3390/cells13171426},
  pmid    = {39272998},
  url     = {https://doi.org/10.3390/cells13171426}
}

@article{braatz2024-36799439,
  author  = {Braatz, Charlotte and Komes, Max P and Ravichandran, Kishore Aravind and de Fragas, Matheus Garcia and Griep, Angelika and Schwartz, Stephanie and McManus, Róisín M and Heneka, Michael T},
  title   = {{NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro}},
  journal = {Journal of neurochemistry},
  year    = {2024},
  doi     = {10.1111/jnc.15778},
  pmid    = {36799439},
  url     = {https://doi.org/10.1111/jnc.15778}
}

@article{wang2025-41062518,
  author  = {Wang, Xiaoxuan and Tian, Haozhe and Chen, Shifei and Ying, Liangliang and Zheng, Juan and Song, Yaya and Xi, Jin and Zhang, Yuxin and others},
  title   = {{Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells}},
  journal = {Scientific reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-19015-5},
  pmid    = {41062518},
  url     = {https://doi.org/10.1038/s41598-025-19015-5}
}

@article{cai2025-39945772,
  author  = {Cai, Zhangying and Wang, Shoutang and Cao, Siyan and Chen, Yun and Penati, Silvia and Peng, Vincent and Yuede, Carla M and Beatty, Wandy L and others},
  title   = {{Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control}},
  journal = {The Journal of experimental medicine},
  year    = {2025},
  doi     = {10.1084/jem.20230173},
  pmid    = {39945772},
  url     = {https://doi.org/10.1084/jem.20230173}
}

@article{maphis2015-25833819,
  author  = {Maphis, Nicole M. and Xu, Guixiang and Kokiko‐Cochran, Olga N. and Jiang, Shanya and Cardona, Astrid E. and Ransohoff, Richard M. and Lamb, Bruce T. and Bhaskar, Kiran},
  title   = {{Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain}},
  journal = {Brain},
  year    = {2015},
  doi     = {10.1093/brain/awv081},
  pmid    = {25833819},
  url     = {https://doi.org/10.1093/brain/awv081}
}

@article{liu2018-29669582,
  author  = {Liu, Y. and Zhang, Y. and Zheng, X. and Fang, T. and Yang, X. and Luo, X. and Guo, A. and Newell, K. A. and others},
  title   = {{Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2018},
  doi     = {10.1186/s12974-018-1141-5},
  pmid    = {29669582},
  url     = {https://doi.org/10.1186/s12974-018-1141-5}
}

@article{luo2019-31040784,
  author  = {Luo, H. and Xiang, Y. and Qu, X. and Liu, H. and Liu, C. and Li, G. and Han, L. and Qin, X.},
  title   = {{Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway}},
  journal = {Frontiers in pharmacology},
  year    = {2019},
  doi     = {10.3389/fphar.2019.00395},
  pmid    = {31040784},
  url     = {https://doi.org/10.3389/fphar.2019.00395}
}

@article{carpanini2019-30886620,
  author  = {Carpanini, S. M. and Torvell, M. and Morgan, B. P.},
  title   = {{Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System}},
  journal = {Frontiers in immunology},
  year    = {2019},
  doi     = {10.3389/fimmu.2019.00362},
  pmid    = {30886620},
  url     = {https://doi.org/10.3389/fimmu.2019.00362}
}

@article{salafrigerio2019-31018141,
  author  = {Sala Frigerio, C. and Wolfs, L. and Fattorelli, N. and Thrupp, N. and Voytyuk, I. and Schmidt, I. and Mancuso, R. and Chen, W. T. and others},
  title   = {{The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques}},
  journal = {Cell reports},
  year    = {2019},
  doi     = {10.1016/j.celrep.2019.03.099},
  pmid    = {31018141},
  url     = {https://doi.org/10.1016/j.celrep.2019.03.099}
}

@article{rangaraju2018-29784049,
  author  = {Rangaraju, S. and Dammer, E. B. and Raza, S. A. and Rathakrishnan, P. and Xiao, H. and Gao, T. and Duong, D. M. and Pennington, M. W. and others},
  title   = {{Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0254-8},
  pmid    = {29784049},
  url     = {https://doi.org/10.1186/s13024-018-0254-8}
}

@article{katsumoto2018-30498474,
  author  = {Katsumoto, A. and Takeuchi, H. and Takahashi, K. and Tanaka, F.},
  title   = {{Microglia in Alzheimer's Disease: Risk Factors and Inflammation}},
  journal = {Frontiers in neurology},
  year    = {2018},
  doi     = {10.3389/fneur.2018.00978},
  pmid    = {30498474},
  url     = {https://doi.org/10.3389/fneur.2018.00978}
}

@article{fuger2017-28846081,
  author  = {Füger, P. and Hefendehl, J. K. and Veeraraghavalu, K. and Wendeln, A. C. and Schlosser, C. and Obermüller, U. and Wegenast-Braun, B. M. and Neher, J. J. and others},
  title   = {{Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging}},
  journal = {Nature neuroscience},
  year    = {2017},
  doi     = {10.1038/nn.4631},
  pmid    = {28846081},
  url     = {https://doi.org/10.1038/nn.4631}
}

@article{poyhonen2019-31105589,
  author  = {Pöyhönen, S. and Er, S. and Domanskyi, A. and Airavaara, M.},
  title   = {{Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury}},
  journal = {Frontiers in physiology},
  year    = {2019},
  doi     = {10.3389/fphys.2019.00486},
  pmid    = {31105589},
  url     = {https://doi.org/10.3389/fphys.2019.00486}
}

@article{jones2017-29312321,
  author  = {Jones, S. V. and Kounatidis, I.},
  title   = {{Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans}},
  journal = {Frontiers in immunology},
  year    = {2017},
  doi     = {10.3389/fimmu.2017.01805},
  pmid    = {29312321},
  url     = {https://doi.org/10.3389/fimmu.2017.01805}
}

@article{kelley2019-31284572,
  author  = {Kelley, N. and Jeltema, D. and Duan, Y. and He, Y.},
  title   = {{The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation}},
  journal = {International journal of molecular sciences},
  year    = {2019},
  doi     = {10.3390/ijms20133328},
  pmid    = {31284572},
  url     = {https://doi.org/10.3390/ijms20133328}
}

@article{coll2015-25686105,
  author  = {Coll, R. C. and Robertson, A. A. and Chae, J. J. and Higgins, S. C. and Muñoz-Planillo, R. and Inserra, M. C. and Vetter, I. and Dungan, L. S. and others},
  title   = {{A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases}},
  journal = {Nature medicine},
  year    = {2015},
  doi     = {10.1038/nm.3806},
  pmid    = {25686105},
  url     = {https://doi.org/10.1038/nm.3806}
}

@article{yang2019-30755589,
  author  = {Yang, Y. and Wang, H. and Kouadir, M. and Song, H. and Shi, F.},
  title   = {{Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors}},
  journal = {Cell death \& disease},
  year    = {2019},
  doi     = {10.1038/s41419-019-1413-8},
  pmid    = {30755589},
  url     = {https://doi.org/10.1038/s41419-019-1413-8}
}

@article{kwon2020-33239064,
  author  = {Kwon, H. S. and Koh, S. H.},
  title   = {{Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes}},
  journal = {Translational neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s40035-020-00221-2},
  pmid    = {33239064},
  url     = {https://doi.org/10.1186/s40035-020-00221-2}
}

@article{meda1995-7715705,
  author  = {Meda, L. and Cassatella, M. A. and Szendrei, G. I. and Otvos, L. and Baron, P. and Villalba, M. and Ferrari, D. and Rossi, F.},
  title   = {{Activation of microglial cells by beta-amyloid protein and interferon-gamma}},
  journal = {Nature},
  year    = {1995},
  doi     = {10.1038/374647a0},
  pmid    = {7715705},
  url     = {https://doi.org/10.1038/374647a0}
}

@article{zhang2019-30936558,
  author  = {Zhang, P. and Kishimoto, Y. and Grammatikakis, I. and Gottimukkala, K. and Cutler, R. G. and Zhang, S. and Abdelmohsen, K. and Bohr, V. A. and others},
  title   = {{Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0372-9},
  pmid    = {30936558},
  url     = {https://doi.org/10.1038/s41593-019-0372-9}
}

@article{simpson2020-32823544,
  author  = {Simpson, D. S. A. and Oliver, P. L.},
  title   = {{ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2020},
  doi     = {10.3390/antiox9080743},
  pmid    = {32823544},
  url     = {https://doi.org/10.3390/antiox9080743}
}

@article{fusco2020-32545788,
  author  = {Fusco, R. and Siracusa, R. and Genovese, T. and Cuzzocrea, S. and Di Paola, R.},
  title   = {{Focus on the Role of NLRP3 Inflammasome in Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21124223},
  pmid    = {32545788},
  url     = {https://doi.org/10.3390/ijms21124223}
}

@article{prinz2017-28092660,
  author  = {Prinz, M. and Priller, J.},
  title   = {{The role of peripheral immune cells in the CNS in steady state and disease}},
  journal = {Nature neuroscience},
  year    = {2017},
  doi     = {10.1038/nn.4475},
  pmid    = {28092660},
  url     = {https://doi.org/10.1038/nn.4475}
}

@article{zenaro2015-26214837,
  author  = {Zenaro, E. and Pietronigro, E. and Della Bianca, V. and Piacentino, G. and Marongiu, L. and Budui, S. and Turano, E. and Rossi, B. and others},
  title   = {{Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin}},
  journal = {Nature medicine},
  year    = {2015},
  doi     = {10.1038/nm.3913},
  pmid    = {26214837},
  url     = {https://doi.org/10.1038/nm.3913}
}

@article{guzmanmartinez2019-31572186,
  author  = {Guzman-Martinez, L. and Maccioni, R. B. and Andrade, V. and Navarrete, L. P. and Pastor, M. G. and Ramos-Escobar, N.},
  title   = {{Neuroinflammation as a Common Feature of Neurodegenerative Disorders}},
  journal = {Frontiers in pharmacology},
  year    = {2019},
  doi     = {10.3389/fphar.2019.01008},
  pmid    = {31572186},
  url     = {https://doi.org/10.3389/fphar.2019.01008}
}

@article{saleh2004-15129283,
  author  = {Saleh, M. and Vaillancourt, J. P. and Graham, R. K. and Huyck, M. and Srinivasula, S. M. and Alnemri, E. S. and Steinberg, M. H. and Nolan, V. and others},
  title   = {{Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms}},
  journal = {Nature},
  year    = {2004},
  doi     = {10.1038/nature02451},
  pmid    = {15129283},
  url     = {https://doi.org/10.1038/nature02451}
}

@article{liang2021-34749609,
  author  = {Liang, Xinyan and Wu, Haijian and Colt, Mark and Guo, Xinying and Pluimer, Brock and Zeng, Jianxiong and Dong, Shupeng and Zhao, Zhen},
  title   = {{Microglia and its Genetics in Alzheimer's Disease}},
  journal = {Current Alzheimer research},
  year    = {2021},
  doi     = {10.2174/1567205018666211105140732},
  pmid    = {34749609},
  url     = {https://doi.org/10.2174/1567205018666211105140732}
}

@article{nott2023-37359515,
  author  = {Nott, Alexi and Holtman, Inge R},
  title   = {{Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease}},
  journal = {Frontiers in immunology},
  year    = {2023},
  doi     = {10.3389/fimmu.2023.1168539},
  pmid    = {37359515},
  url     = {https://doi.org/10.3389/fimmu.2023.1168539}
}

@article{jonas2022-35078351,
  author  = {Jonas, Lauren A and Jain, Tanya and Li, Yue-Ming},
  title   = {{Functional insight into LOAD-associated microglial response genes}},
  journal = {Open biology},
  year    = {2022},
  doi     = {10.1098/rsob.210280},
  pmid    = {35078351},
  url     = {https://doi.org/10.1098/rsob.210280}
}

@article{chappie2022-35059124,
  author  = {Chappie, Thomas A and Abdelmessih, Mario and Ambroise, Claude W and Boehm, Markus and Cai, Mi and Green, Michael and Guilmette, Edward and Steppan, Claire M and others},
  title   = {{Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators}},
  journal = {ACS medicinal chemistry letters},
  year    = {2022},
  doi     = {10.1021/acsmedchemlett.1c00396},
  pmid    = {35059124},
  url     = {https://doi.org/10.1021/acsmedchemlett.1c00396}
}

@article{shafi2021-33786894,
  author  = {Shafi, Sadat and Singh, Archu and Ibrahim, Abdallah Mohammad and Alhajri, Noora and Izneid, Tareq Abu and Pottoo, Faheem Hyder},
  title   = {{Role of triggering receptor expressed on myeloid cells 2 (TREM2) in neurodegenerative dementias}},
  journal = {The European journal of neuroscience},
  year    = {2021},
  doi     = {10.1111/ejn.15215},
  pmid    = {33786894},
  url     = {https://doi.org/10.1111/ejn.15215}
}

@article{essex2022-35575023,
  author  = {Essex, Alyson L and Huot, Joshua R and Deosthale, Padmini and Wagner, Alison and Figueras, Jorge and Davis, Azaria and Damrath, John and Pin, Fabrizio and others},
  title   = {{Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice}},
  journal = {Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year    = {2022},
  doi     = {10.1002/jbmr.4572},
  pmid    = {35575023},
  url     = {https://doi.org/10.1002/jbmr.4572}
}

@article{bandow2022-36283335,
  author  = {Bandow, Kenjiro and Smith, Avi and Garlick, Jonathan},
  title   = {{Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) positively regulates lipopolysaccharide-induced expression of CXC chemokine ligand 10 and 11 in mouse macrophages}},
  journal = {Biochemical and biophysical research communications},
  year    = {2022},
  doi     = {10.1016/j.bbrc.2022.10.048},
  pmid    = {36283335},
  url     = {https://doi.org/10.1016/j.bbrc.2022.10.048}
}

@article{katsumoto2022-36389767,
  author  = {Katsumoto, Atsuko and Kokiko-Cochran, Olga N and Bemiller, Shane M and Xu, Guixiang and Ransohoff, Richard M and Lamb, Bruce T},
  title   = {{Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.978423},
  pmid    = {36389767},
  url     = {https://doi.org/10.3389/fimmu.2022.978423}
}

@article{cheng2021-33841415,
  author  = {Cheng, Baoying and Li, Xin and Dai, Kai and Duan, Shengshun and Rong, Zhouyi and Chen, Yingmin and Lü, Liangcheng and Liu, Zhaoji and others},
  title   = {{Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.633796},
  pmid    = {33841415},
  url     = {https://doi.org/10.3389/fimmu.2021.633796}
}

@article{schwarz2022-35752274,
  author  = {Schwarz, Hannah and Bässler, Sarah and Balta, Denise and Socher, Eileen and Zunke, Friederike and Arnold, Philipp},
  title   = {{The role of triggering receptor expressed on myeloid cells 2 in Parkinson's disease and other neurodegenerative disorders}},
  journal = {Behavioural brain research},
  year    = {2022},
  doi     = {10.1016/j.bbr.2022.113977},
  pmid    = {35752274},
  url     = {https://doi.org/10.1016/j.bbr.2022.113977}
}

@article{qiao2023-36721205,
  author  = {Qiao, Wenhui and Chen, Yixing and Zhong, Jun and Madden, Benjamin J and Charlesworth, Cristine M and Martens, Yuka A and Liu, Chia-Chen and Knight, Joshua and others},
  title   = {{Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00599-3},
  pmid    = {36721205},
  url     = {https://doi.org/10.1186/s13024-023-00599-3}
}

@article{olufunmilayo2022-35120968,
  author  = {Olufunmilayo, Edward O and Holsinger, R M Damian},
  title   = {{Variant TREM2 Signaling in Alzheimer's Disease}},
  journal = {Journal of molecular biology},
  year    = {2022},
  doi     = {10.1016/j.jmb.2022.167470},
  pmid    = {35120968},
  url     = {https://doi.org/10.1016/j.jmb.2022.167470}
}

@article{wijegunawardena2023-37235776,
  author  = {Wijegunawardena, Gayani and Castillo, Erika and Henrickson, Brandy and Davis, Regan and Condello, Carlo and Wu, Haifan},
  title   = {{Total Chemical Synthesis of Glycosylated TREM2 Ectodomain}},
  journal = {ACS chemical neuroscience},
  year    = {2023},
  doi     = {10.1021/acschemneuro.3c00257},
  pmid    = {37235776},
  url     = {https://doi.org/10.1021/acschemneuro.3c00257}
}

@article{larosa2023-37239970,
  author  = {La Rosa, Francesca and Agostini, Simone and Piancone, Federica and Marventano, Ivana and Hernis, Ambra and Fenoglio, Chiara and Galimberti, Daniela and Scarpini, Elio and others},
  title   = {{TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24108626},
  pmid    = {37239970},
  url     = {https://doi.org/10.3390/ijms24108626}
}

@article{okuzono2021-34523252,
  author  = {Okuzono, Yuumi and Sakuma, Hiroyuki and Miyakawa, Shuuichi and Ifuku, Masataka and Lee, Jonghun and Das, Debashree and Banerjee, Antara and Zhao, Yang and others},
  title   = {{Reduced TREM2 activation in microglia of patients with Alzheimer's disease}},
  journal = {FEBS open bio},
  year    = {2021},
  doi     = {10.1002/2211-5463.13300},
  pmid    = {34523252},
  url     = {https://doi.org/10.1002/2211-5463.13300}
}

@article{yu2023-36318443,
  author  = {Yu, Chao-Ji and Wang, Meng and Li, Rui-Yang and Wei, Tao and Yang, Han-Chen and Yin, Yun-Si and Mi, Ying-Xin and Qin, Qi and others},
  title   = {{TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-022-03100-1},
  pmid    = {36318443},
  url     = {https://doi.org/10.1007/s12035-022-03100-1}
}

@article{lee2021-33980160,
  author  = {Lee, Hwa-Youn and Lee, Eun-Hee and Yi, Jawoon and Ji, Kon-Young and Kim, Su-Man and Choi, Ha-Rim and Yee, Su-Min and Kang, Hyung-Sik and others},
  title   = {{TREM2 promotes natural killer cell development in CD3-CD122+NK1.1+ pNK cells}},
  journal = {BMC immunology},
  year    = {2021},
  doi     = {10.1186/s12865-021-00420-0},
  pmid    = {33980160},
  url     = {https://doi.org/10.1186/s12865-021-00420-0}
}

@article{kulkarni2021-34275100,
  author  = {Kulkarni, Bhargavi and Kumar, Dileep and Cruz-Martins, Natália and Sellamuthu, Satheeshkumar},
  title   = {{Role of TREM2 in Alzheimer's Disease: A Long Road Ahead}},
  journal = {Molecular neurobiology},
  year    = {2021},
  doi     = {10.1007/s12035-021-02477-9},
  pmid    = {34275100},
  url     = {https://doi.org/10.1007/s12035-021-02477-9}
}

@article{fu2023-37190607,
  author  = {Fu, Xin-Xin and Chen, Shuai-Yu and Lian, Hui-Wen and Deng, Yang and Duan, Rui and Zhang, Ying-Dong and Jiang, Teng},
  title   = {{The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release}},
  journal = {Brain sciences},
  year    = {2023},
  doi     = {10.3390/brainsci13040642},
  pmid    = {37190607},
  url     = {https://doi.org/10.3390/brainsci13040642}
}

@article{chu2023-37525057,
  author  = {Chu, Yung Ning and Akahori, Aika and Takatori, Sho and Tomita, Taisuke},
  title   = {{Pathological Roles of INPP5D in Alzheimer's Disease}},
  journal = {Advances in experimental medicine and biology},
  year    = {2023},
  doi     = {10.1007/978-3-031-31978-5_30},
  pmid    = {37525057},
  url     = {https://doi.org/10.1007/978-3-031-31978-5_30}
}

@article{liu2023-38176932,
  author  = {Liu, Guangtong and Zhang, Linlin and Fan, Yongzhao and Ji, Wenliang},
  title   = {{The Pathogenesis in Alzheimer's Disease: TREM2 as a Potential Target}},
  journal = {Journal of integrative neuroscience},
  year    = {2023},
  doi     = {10.31083/j.jin2206150},
  pmid    = {38176932},
  url     = {https://doi.org/10.31083/j.jin2206150}
}

@article{magno2021-33823896,
  author  = {Magno, Lorenza and Bunney, Tom D and Mead, Emma and Svensson, Fredrik and Bictash, Magda N},
  title   = {{TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00436-5},
  pmid    = {33823896},
  url     = {https://doi.org/10.1186/s13024-021-00436-5}
}

@article{wolf2022-36119485,
  author  = {Wolf, Elysa M and Fingleton, Barbara and Hasty, Alyssa H},
  title   = {{The therapeutic potential of TREM2 in cancer}},
  journal = {Frontiers in oncology},
  year    = {2022},
  doi     = {10.3389/fonc.2022.984193},
  pmid    = {36119485},
  url     = {https://doi.org/10.3389/fonc.2022.984193}
}

@article{ibach2021-33314333,
  author  = {Ibach, Melanie and Mathews, Mona and Linnartz-Gerlach, Bettina and Theil, Sandra and Kumar, Sathish and Feederle, Regina and Brüstle, Oliver and Neumann, Harald and others},
  title   = {{A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.23953},
  pmid    = {33314333},
  url     = {https://doi.org/10.1002/glia.23953}
}

@article{joshi2021-34427354,
  author  = {Joshi, Pranav and Riffel, Florian and Satoh, Kanayo and Enomoto, Masahiro and Qamar, Seema and Scheiblich, Hannah and Villacampa, Nàdia and Kumar, Sathish and others},
  title   = {{Differential interaction with TREM2 modulates microglial uptake of modified Aβ species}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.24077},
  pmid    = {34427354},
  url     = {https://doi.org/10.1002/glia.24077}
}

@article{xue2021-33557250,
  author  = {Xue, Feng and Du, Heng},
  title   = {{TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10020321},
  pmid    = {33557250},
  url     = {https://doi.org/10.3390/cells10020321}
}

@article{biundo2023-37626591,
  author  = {Biundo, Fabrizio and Chitu, Violeta and Gökhan, Şölen and Chen, Edward and Oppong-Asare, Jude and Stanley, E Richard},
  title   = {{Trem2 Enhances Demyelination in the Csf1r+/- Mouse Model of Leukoencephalopathy}},
  journal = {Biomedicines},
  year    = {2023},
  doi     = {10.3390/biomedicines11082094},
  pmid    = {37626591},
  url     = {https://doi.org/10.3390/biomedicines11082094}
}

@article{vanderende2021-33896652,
  author  = {van der Ende, Emma L and Morenas-Rodriguez, Estrella and McMillan, Corey and Grossman, Murray and Irwin, David and Sanchez-Valle, Raquel and Graff, Caroline and Vandenberghe, Rik and others},
  title   = {{CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2021.02.024},
  pmid    = {33896652},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2021.02.024}
}

@article{boudesco2022-35912412,
  author  = {Boudesco, Christophe and Nonneman, Annelies and Cinti, Alessandro and Picardi, Paola and Redaelli, Loredana and Swijsen, Sofie and Roewe, Julian and Reinhardt, Peter and others},
  title   = {{Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells}},
  journal = {Glia},
  year    = {2022},
  doi     = {10.1002/glia.24252},
  pmid    = {35912412},
  url     = {https://doi.org/10.1002/glia.24252}
}

@article{degea2023-38162003,
  author  = {de Gea, Priscille and Benkeder, Sarah and Bouvet, Pauline and Aimard, Mélanie and Chounlamountri, Naura and Honnorat, Jérôme and Do, Le Duy and Meissirel, Claire},
  title   = {{VEGF controls microglial phagocytic response to amyloid-β}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2023},
  doi     = {10.3389/fncel.2023.1264402},
  pmid    = {38162003},
  url     = {https://doi.org/10.3389/fncel.2023.1264402}
}

@article{qu2023-34470515,
  author  = {Qu, Wenhui and Li, Ling},
  title   = {{Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2023},
  doi     = {10.1177/10738584211040786},
  pmid    = {34470515},
  url     = {https://doi.org/10.1177/10738584211040786}
}

@article{zhang2023-37926352,
  author  = {Zhang, Xin and Chen, Xue and Zhang, Ling and Sun, Yuqing and Liang, Ying and Li, Huan and Zhang, Yulin},
  title   = {{Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia}},
  journal = {Neurochemistry international},
  year    = {2023},
  doi     = {10.1016/j.neuint.2023.105639},
  pmid    = {37926352},
  url     = {https://doi.org/10.1016/j.neuint.2023.105639}
}

@article{koh2021-34884940,
  author  = {Koh, Han Seok and Lee, SangJoon and Lee, Hyo Jin and Min, Jae-Woong and Iwatsubo, Takeshi and Teunissen, Charlotte E and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222313136},
  pmid    = {34884940},
  url     = {https://doi.org/10.3390/ijms222313136}
}

@article{mansour2021-34139302,
  author  = {Mansour, Heba M and Fawzy, Hala M and El-Khatib, Aiman S and Khattab, Mahmoud M},
  title   = {{Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer's Disease: Current Perspectives and Challenging Prospects}},
  journal = {Neuroscience},
  year    = {2021},
  doi     = {10.1016/j.neuroscience.2021.06.013},
  pmid    = {34139302},
  url     = {https://doi.org/10.1016/j.neuroscience.2021.06.013}
}

@article{kosyreva2022-36138973,
  author  = {Kosyreva, Anna Mikhailovna and Sentyabreva, Alexandra Vladislavovna and Tsvetkov, Ivan Sergeevich and Makarova, Olga Vasilievna},
  title   = {{Alzheimer's Disease and Inflammaging}},
  journal = {Brain sciences},
  year    = {2022},
  doi     = {10.3390/brainsci12091237},
  pmid    = {36138973},
  url     = {https://doi.org/10.3390/brainsci12091237}
}

@article{merighi2022-36361780,
  author  = {Merighi, Stefania and Nigro, Manuela and Travagli, Alessia and Gessi, Stefania},
  title   = {{Microglia and Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms232112990},
  pmid    = {36361780},
  url     = {https://doi.org/10.3390/ijms232112990}
}

@article{kim2021-34638977,
  author  = {Kim, Jieun and Lee, Hyun-Ju and Park, Seon Kyeong and Park, Jin-Hee and Jeong, Ha-Ram and Lee, Soojung and Lee, Heeyong and Seol, Eunyoung and others},
  title   = {{Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms221910637},
  pmid    = {34638977},
  url     = {https://doi.org/10.3390/ijms221910637}
}

@article{freitag2022-35780157,
  author  = {Freitag, Kiara and Sterczyk, Nele and Wendlinger, Sarah and Obermayer, Benedikt and Schulz, Julia and Farztdinov, Vadim and Mülleder, Michael and Ralser, Markus and others},
  title   = {{Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02534-7},
  pmid    = {35780157},
  url     = {https://doi.org/10.1186/s12974-022-02534-7}
}

@article{dedios2023-36895045,
  author  = {de Dios, Cristina and Abadin, Xenia and Roca-Agujetas, Vicente and Jimenez-Martinez, Marina and Morales, Albert and Trullas, Ramon and Mari, Montserrat and Colell, Anna},
  title   = {{Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis}},
  journal = {Translational neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s40035-023-00343-3},
  pmid    = {36895045},
  url     = {https://doi.org/10.1186/s40035-023-00343-3}
}

@article{gong2022-36017373,
  author  = {Gong, Ting and Chen, Qi and Mao, Hongchen and Zhang, Yao and Ren, Huan and Xu, Mengmeng and Chen, Hong and Yang, Deqin},
  title   = {{Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice}},
  journal = {Frontiers in cellular and infection microbiology},
  year    = {2022},
  doi     = {10.3389/fcimb.2022.925435},
  pmid    = {36017373},
  url     = {https://doi.org/10.3389/fcimb.2022.925435}
}

@article{li2023-37165444,
  author  = {Li, Jia-Mei and Hu, Ting and Zhou, Xiao-Na and Zhang, Ting and Guo, Jia-Hui and Wang, Min-Yuan and Wu, Yi-Lin and Su, Wen-Jun and others},
  title   = {{The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02791-0},
  pmid    = {37165444},
  url     = {https://doi.org/10.1186/s12974-023-02791-0}
}

@article{shah2021-34948444,
  author  = {Shah, Akash and Kishore, Uday and Shastri, Abhishek},
  title   = {{Complement System in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222413647},
  pmid    = {34948444},
  url     = {https://doi.org/10.3390/ijms222413647}
}

@article{shu2023-36800288,
  author  = {Shu, Xiaoqiu and Wei, Chen and Tu, Wen-Yo and Zhong, Keke and Qi, Shuyuan and Wang, Ailian and Bai, Lei and Zhang, Shan-Xin and others},
  title   = {{Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome}},
  journal = {Cell reports},
  year    = {2023},
  doi     = {10.1016/j.celrep.2023.112133},
  pmid    = {36800288},
  url     = {https://doi.org/10.1016/j.celrep.2023.112133}
}

@article{vanzeller2021-34366341,
  author  = {Van Zeller, Mariana and Dias, Diogo and Sebastião, Ana M and Valente, Cláudia A},
  title   = {{NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210268},
  pmid    = {34366341},
  url     = {https://doi.org/10.3233/jad-210268}
}

@article{ravichandran2021-34846519,
  author  = {Ravichandran, Kishore Aravind and Heneka, Michael T},
  title   = {{Inflammasome activation in neurodegenerative diseases}},
  journal = {Essays in biochemistry},
  year    = {2021},
  doi     = {10.1042/ebc20210021},
  pmid    = {34846519},
  url     = {https://doi.org/10.1042/ebc20210021}
}

@article{barczuk2022-36012243,
  author  = {Barczuk, Julia and Siwecka, Natalia and Lusa, Weronika and Rozpędek-Kamińska, Wioletta and Kucharska, Ewa and Majsterek, Ireneusz},
  title   = {{Targeting NLRP3-Mediated Neuroinflammation in Alzheimer's Disease Treatment}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23168979},
  pmid    = {36012243},
  url     = {https://doi.org/10.3390/ijms23168979}
}

@article{zhou2023-37268807,
  author  = {Zhou, Ran and Chen, Shih-Heng and Zhao, Zhan and Tu, Dezhen and Song, Sheng and Wang, Yubao and Wang, Qingshan and Feng, Jing and others},
  title   = {{Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-023-03393-w},
  pmid    = {37268807},
  url     = {https://doi.org/10.1007/s12035-023-03393-w}
}

@article{holbrook2021-33776778,
  author  = {Holbrook, Jonathan A and Jarosz-Griffiths, Heledd H and Caseley, Emily and Lara-Reyna, Samuel and Poulter, James A and Williams-Gray, Caroline H and Peckham, Daniel and McDermott, Michael F},
  title   = {{Neurodegenerative Disease and the NLRP3 Inflammasome}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.643254},
  pmid    = {33776778},
  url     = {https://doi.org/10.3389/fphar.2021.643254}
}

@article{rather2021-34381308,
  author  = {Rather, Mashoque Ahmad and Khan, Andleeb and Alshahrani, Saeed and Rashid, Hina and Qadri, Marwa and Rashid, Summya and Alsaffar, Rana M and Kamal, Mohammad Amjad and others},
  title   = {{Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products}},
  journal = {Mediators of inflammation},
  year    = {2021},
  doi     = {10.1155/2021/9982954},
  pmid    = {34381308},
  url     = {https://doi.org/10.1155/2021/9982954}
}

@article{zhang2021-34430820,
  author  = {Zhang, Liansheng and Qian, Yun and Li, Jie and Zhou, Xuan and Xu, He and Yan, Jie and Xiang, Jialing and Yuan, Xiang and others},
  title   = {{BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology}},
  journal = {iScience},
  year    = {2021},
  doi     = {10.1016/j.isci.2021.102942},
  pmid    = {34430820},
  url     = {https://doi.org/10.1016/j.isci.2021.102942}
}

@article{lee2021-34668411,
  author  = {Lee, SangJoon and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Innate Immunity and Cell Death in Alzheimer's Disease}},
  journal = {ASN neuro},
  year    = {2021},
  doi     = {10.1177/17590914211051908},
  pmid    = {34668411},
  url     = {https://doi.org/10.1177/17590914211051908}
}

@article{milner2021-33181351,
  author  = {Milner, Mark T and Maddugoda, Madhavi and Götz, Jürgen and Burgener, Sabrina S and Schroder, Kate},
  title   = {{The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease}},
  journal = {Current opinion in immunology},
  year    = {2021},
  doi     = {10.1016/j.coi.2020.10.011},
  pmid    = {33181351},
  url     = {https://doi.org/10.1016/j.coi.2020.10.011}
}

@article{toscano2021-34530705,
  author  = {Toscano, Eliana C de Brito and Rocha, Natalia P and Lopes, Beatriz N A and Suemoto, Claudia K and Teixeira, Antonio L},
  title   = {{Neuroinflammation in Alzheimer's Disease: Focus on NLRP1 and NLRP3 Inflammasomes}},
  journal = {Current protein \& peptide science},
  year    = {2021},
  doi     = {10.2174/1389203722666210916141436},
  pmid    = {34530705},
  url     = {https://doi.org/10.2174/1389203722666210916141436}
}

@article{gao2023-37328043,
  author  = {Gao, Dan and Hao, Jin-Ping and Li, Bo-Ya and Zheng, Ceng-Ceng and Miao, Bei-Bei and Zhang, Li and Li, Ya-Li and Li, Lin and others},
  title   = {{Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING}},
  journal = {European journal of pharmacology},
  year    = {2023},
  doi     = {10.1016/j.ejphar.2023.175809},
  pmid    = {37328043},
  url     = {https://doi.org/10.1016/j.ejphar.2023.175809}
}

@article{sandhu2021-33499208,
  author  = {Sandhu, Jagdeep K and Kulka, Marianna},
  title   = {{Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22031093},
  pmid    = {33499208},
  url     = {https://doi.org/10.3390/ijms22031093}
}

@article{mamsa2023-37652164,
  author  = {Mamsa, Rumaiza and Prabhavalkar, Kedar S and Bhatt, Lokesh Kumar},
  title   = {{Crosstalk between NLRP3 inflammasome and calpain in Alzheimer's disease}},
  journal = {The European journal of neuroscience},
  year    = {2023},
  doi     = {10.1111/ejn.16139},
  pmid    = {37652164},
  url     = {https://doi.org/10.1111/ejn.16139}
}

@article{trudler2021-33833060,
  author  = {Trudler, Dorit and Nazor, Kristopher L and Eisele, Yvonne S and Grabauskas, Titas and Dolatabadi, Nima and Parker, James and Sultan, Abdullah and Zhong, Zhenyu and others},
  title   = {{Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2025847118},
  pmid    = {33833060},
  url     = {https://doi.org/10.1073/pnas.2025847118}
}

@article{lei2021-33641782,
  author  = {Lei, Li-Yan and Wang, Rui-Cheng and Pan, Ya-Lei and Yue, Zheng-Gang and Zhou, Rui and Xie, Pei and Tang, Zhi-Shu},
  title   = {{Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway}},
  journal = {Chinese journal of natural medicines},
  year    = {2021},
  doi     = {10.1016/s1875-5364(21)60012-2},
  pmid    = {33641782},
  url     = {https://doi.org/10.1016/s1875-5364(21)60012-2}
}

@article{brahadeeswaran2022-35066762,
  author  = {Brahadeeswaran, Subhashini and Sivagurunathan, Narmadhaa and Calivarathan, Latchoumycandane},
  title   = {{Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases}},
  journal = {Molecular neurobiology},
  year    = {2022},
  doi     = {10.1007/s12035-021-02683-5},
  pmid    = {35066762},
  url     = {https://doi.org/10.1007/s12035-021-02683-5}
}

@article{jia2023-37721665,
  author  = {Jia, Yue-Ran and Guo, Zi-Qing and Guo, Qian and Wang, Xiao-Chuan},
  title   = {{Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer's Disease}},
  journal = {Current medical science},
  year    = {2023},
  doi     = {10.1007/s11596-023-2788-4},
  pmid    = {37721665},
  url     = {https://doi.org/10.1007/s11596-023-2788-4}
}

@article{han2023-37725102,
  author  = {Han, Ying-Hao and Liu, Xiao-Dong and Jin, Mei-Hua and Sun, Hu-Nan and Kwon, Taeho},
  title   = {{Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases}},
  journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]},
  year    = {2023},
  doi     = {10.1007/s00011-023-01790-4},
  pmid    = {37725102},
  url     = {https://doi.org/10.1007/s00011-023-01790-4}
}

@article{xu2021-34187889,
  author  = {Xu, Yin and Propson, Nicholas E and Du, Shuqi and Xiong, Wen and Zheng, Hui},
  title   = {{Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2023418118},
  pmid    = {34187889},
  url     = {https://doi.org/10.1073/pnas.2023418118}
}

@article{bohlson2023-36750318,
  author  = {Bohlson, Suzanne S and Tenner, Andrea J},
  title   = {{Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation}},
  journal = {Annual review of immunology},
  year    = {2023},
  doi     = {10.1146/annurev-immunol-101921-035639},
  pmid    = {36750318},
  url     = {https://doi.org/10.1146/annurev-immunol-101921-035639}
}

@article{chen2023-36018184,
  author  = {Chen, Feng and Liu, Jing and Li, Fa-Qiang and Wang, Shuai-Shuai and Zhang, Yan-Yan and Lu, Yun-Yun and Hu, Fang-Fang and Yao, Rui-Qin},
  title   = {{β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats}},
  journal = {Neural regeneration research},
  year    = {2023},
  doi     = {10.4103/1673-5374.350204},
  pmid    = {36018184},
  url     = {https://doi.org/10.4103/1673-5374.350204}
}

@article{golzarisorkheh2021-34569958,
  author  = {Golzari-Sorkheh, Mahdieh and Brown, Carla E and Weaver, Donald F and Reed, Mark A},
  title   = {{The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210660},
  pmid    = {34569958},
  url     = {https://doi.org/10.3233/jad-210660}
}

@article{jung2022-35474599,
  author  = {Jung, Eun Sun and Suh, Kyujin and Han, Jihui and Kim, Heyyoung and Kang, Hyung-Sik and Choi, Won-Seok and Mook-Jung, Inhee},
  title   = {{Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway}},
  journal = {Aging cell},
  year    = {2022},
  doi     = {10.1111/acel.13623},
  pmid    = {35474599},
  url     = {https://doi.org/10.1111/acel.13623}
}

@article{sita2021-34209586,
  author  = {Sita, Giulia and Graziosi, Agnese and Hrelia, Patrizia and Morroni, Fabiana},
  title   = {{NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22136984},
  pmid    = {34209586},
  url     = {https://doi.org/10.3390/ijms22136984}
}

@article{ghosh2021-34656693,
  author  = {Ghosh, Powsali and Singh, Ravi and Ganeshpurkar, Ankit and Pokle, Ankit Vyankatrao and Singh, Ravi Bhushan and Singh, Sushil Kumar and Kumar, Ashok},
  title   = {{Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts \& roles}},
  journal = {Neurochemistry international},
  year    = {2021},
  doi     = {10.1016/j.neuint.2021.105212},
  pmid    = {34656693},
  url     = {https://doi.org/10.1016/j.neuint.2021.105212}
}

@article{delaney2021-33350588,
  author  = {Delaney, Conor and Farrell, Michael and Doherty, Colin P and Brennan, Kiva and O'Keeffe, Eoin and Greene, Chris and Byrne, Kieva and Kelly, Eoin and others},
  title   = {{Attenuated CSF-1R signalling drives cerebrovascular pathology}},
  journal = {EMBO molecular medicine},
  year    = {2021},
  doi     = {10.15252/emmm.202012889},
  pmid    = {33350588},
  url     = {https://doi.org/10.15252/emmm.202012889}
}

@article{fernandez2021-34177557,
  author  = {Fernández, Dominique and Geisse, Antonia and Bernales, Jose Ignacio and Lira, Alonso and Osorio, Fabiola},
  title   = {{The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.682633},
  pmid    = {34177557},
  url     = {https://doi.org/10.3389/fnagi.2021.682633}
}

@article{shi2019-31601677,
  author  = {Shi, Yang and Manis, Melissa and Long, Justin M. and Wang, Kairuo and Sullivan, Patrick M. and Serrano, Javier Remolina and Hoyle, Rosa and Holtzman, David M.},
  title   = {{Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model}},
  journal = {The Journal of Experimental Medicine},
  year    = {2019},
  doi     = {10.1084/jem.20190980},
  pmid    = {31601677},
  url     = {https://doi.org/10.1084/jem.20190980}
}

@article{magno2019-30711010,
  author  = {Magno, Lorenza and Lessard, Christian B. and Martins, Marta and Lang, Verena and Cruz, Pedro E. and Asi, Yasmine T. and Katan, Matilda and Bilsland, Jamie and others},
  title   = {{Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0469-0},
  pmid    = {30711010},
  url     = {https://doi.org/10.1186/s13195-019-0469-0}
}

@article{elsahar2020-33125461,
  author  = {El-Sahar, Ayman E. and Shiha, Nesma A. and El Sayed, Nesrine S. and Ahmed, Lamiaa A.},
  title   = {{Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways}},
  journal = {The International Journal of Neuropsychopharmacology},
  year    = {2020},
  doi     = {10.1093/ijnp/pyaa078},
  pmid    = {33125461},
  url     = {https://doi.org/10.1093/ijnp/pyaa078}
}

@article{jin2008-18510752,
  author  = {Jin, J. J. and Kim, H. D. and Maxwell, J. A. and Li, L. and Fukuchi, K.},
  title   = {{Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-23},
  pmid    = {18510752},
  url     = {https://doi.org/10.1186/1742-2094-5-23}
}

@article{martinmoreno2012-22248049,
  author  = {Martín-Moreno, A. M. and Brera, B. and Spuch, C. and Carro, E. and García-García, L. and Delgado, M. and Pozo, M. A. and Innamorato, N. G. and others},
  title   = {{Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice}},
  journal = {Journal of neuroinflammation},
  year    = {2012},
  doi     = {10.1186/1742-2094-9-8},
  pmid    = {22248049},
  url     = {https://doi.org/10.1186/1742-2094-9-8}
}

@article{hermes2008-18947414,
  author  = {Hermes, G. and Ajioka, J. W. and Kelly, K. A. and Mui, E. and Roberts, F. and Kasza, K. and Mayr, T. and Kirisits, M. J. and others},
  title   = {{Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-48},
  pmid    = {18947414},
  url     = {https://doi.org/10.1186/1742-2094-5-48}
}

@article{lehmann2012-22610069,
  author  = {Lehmann, S. M. and Krüger, C. and Park, B. and Derkow, K. and Rosenberger, K. and Baumgart, J. and Trimbuch, T. and Eom, G. and others},
  title   = {{An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration}},
  journal = {Nature neuroscience},
  year    = {2012},
  doi     = {10.1038/nn.3113},
  pmid    = {22610069},
  url     = {https://doi.org/10.1038/nn.3113}
}

@article{butler2021-33608912,
  author  = {Butler, C. A. and Popescu, A. S. and Kitchener, E. J. A. and Allendorf, D. H. and Puigdellívol, M. and Brown, G. C.},
  title   = {{Microglial phagocytosis of neurons in neurodegeneration, and its regulation}},
  journal = {Journal of neurochemistry},
  year    = {2021},
  doi     = {10.1111/jnc.15327},
  pmid    = {33608912},
  url     = {https://doi.org/10.1111/jnc.15327}
}

@article{lee2008-18759972,
  author  = {Lee, J. W. and Lee, Y. K. and Yuk, D. Y. and Choi, D. Y. and Ban, S. B. and Oh, K. W. and Hong, J. T.},
  title   = {{Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-37},
  pmid    = {18759972},
  url     = {https://doi.org/10.1186/1742-2094-5-37}
}

@article{sun2023-37774678,
  author  = {Sun, N. and Victor, M. B. and Park, Y. P. and Xiong, X. and Scannail, A. N. and Leary, N. and Prosper, S. and Viswanathan, S. and others},
  title   = {{Human microglial state dynamics in Alzheimer's disease progression}},
  journal = {Cell},
  year    = {2023},
  doi     = {10.1016/j.cell.2023.08.037},
  pmid    = {37774678},
  url     = {https://doi.org/10.1016/j.cell.2023.08.037}
}

@article{calsolaro2016-27179961,
  author  = {Calsolaro, V. and Edison, P.},
  title   = {{Neuroinflammation in Alzheimer's disease: Current evidence and future directions}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.02.010},
  pmid    = {27179961},
  url     = {https://doi.org/10.1016/j.jalz.2016.02.010}
}

@article{amanollahi2023-36383328,
  author  = {Amanollahi, M. and Jameie, M. and Heidari, A. and Rezaei, N.},
  title   = {{The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-022-03102-z},
  pmid    = {36383328},
  url     = {https://doi.org/10.1007/s12035-022-03102-z}
}

@article{huang2021-34321623,
  author  = {Huang, Y. and Xu, W. and Zhou, R.},
  title   = {{NLRP3 inflammasome activation and cell death}},
  journal = {Cellular \& molecular immunology},
  year    = {2021},
  doi     = {10.1038/s41423-021-00740-6},
  pmid    = {34321623},
  url     = {https://doi.org/10.1038/s41423-021-00740-6}
}

@article{sheedy2013-23812099,
  author  = {Sheedy, F. J. and Grebe, A. and Rayner, K. J. and Kalantari, P. and Ramkhelawon, B. and Carpenter, S. B. and Becker, C. E. and others},
  title   = {{CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation}},
  journal = {Nature immunology},
  year    = {2013},
  doi     = {10.1038/ni.2639},
  pmid    = {23812099},
  url     = {https://doi.org/10.1038/ni.2639}
}

@article{brites2015-26733805,
  author  = {Brites, D. and Fernandes, A.},
  title   = {{Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2015},
  doi     = {10.3389/fncel.2015.00476},
  pmid    = {26733805},
  url     = {https://doi.org/10.3389/fncel.2015.00476}
}

@article{sayan2016-27650313,
  author  = {Sayan, M. and Mossman, B. T.},
  title   = {{The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases}},
  journal = {Particle and fibre toxicology},
  year    = {2016},
  doi     = {10.1186/s12989-016-0162-4},
  pmid    = {27650313},
  url     = {https://doi.org/10.1186/s12989-016-0162-4}
}

@article{streit2004-15285801,
  author  = {Streit, W. J. and Mrak, R. E. and Griffin, W. S.},
  title   = {{Microglia and neuroinflammation: a pathological perspective}},
  journal = {Journal of neuroinflammation},
  year    = {2004},
  doi     = {10.1186/1742-2094-1-14},
  pmid    = {15285801},
  url     = {https://doi.org/10.1186/1742-2094-1-14}
}

@article{pan2022-35303422,
  author  = {Pan, R. Y. and He, L. and Zhang, J. and Liu, X. and Liao, Y. and Gao, J. and Yan, Y. and others},
  title   = {{Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease}},
  journal = {Cell metabolism},
  year    = {2022},
  doi     = {10.1016/j.cmet.2022.02.013},
  pmid    = {35303422},
  url     = {https://doi.org/10.1016/j.cmet.2022.02.013}
}

@article{mccoy2008-18925972,
  author  = {McCoy, M. K. and Tansey, M. G.},
  title   = {{TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-45},
  pmid    = {18925972},
  url     = {https://doi.org/10.1186/1742-2094-5-45}
}

@article{pekny2016-26671410,
  author  = {Pekny, M. and Pekna, M. and Messing, A. and Steinhäuser, C. and Lee, J. M. and Parpura, V. and Hol, E. M. and Sofroniew, M. V. and others},
  title   = {{Astrocytes: a central element in neurological diseases}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-015-1513-1},
  pmid    = {26671410},
  url     = {https://doi.org/10.1007/s00401-015-1513-1}
}

@article{rubioperez2012-22566778,
  author  = {Rubio-Perez, J. M. and Morillas-Ruiz, J. M.},
  title   = {{A review: inflammatory process in Alzheimer's disease, role of cytokines}},
  journal = {TheScientificWorldJournal},
  year    = {2012},
  doi     = {10.1100/2012/756357},
  pmid    = {22566778},
  url     = {https://doi.org/10.1100/2012/756357}
}

@article{spangenberg2016-26921617,
  author  = {Spangenberg, E. E. and Lee, R. J. and Najafi, A. R. and Rice, R. A. and Elmore, M. R. and Blurton-Jones, M. and West, B. L. and Green, K. N.},
  title   = {{Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology}},
  journal = {Brain : a journal of neurology},
  year    = {2016},
  doi     = {10.1093/brain/aww016},
  pmid    = {26921617},
  url     = {https://doi.org/10.1093/brain/aww016}
}

@article{sierra2013-23386811,
  author  = {Sierra, A. and Abiega, O. and Shahraz, A. and Neumann, H.},
  title   = {{Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2013},
  doi     = {10.3389/fncel.2013.00006},
  pmid    = {23386811},
  url     = {https://doi.org/10.3389/fncel.2013.00006}
}

@article{kann2022-36283867,
  author  = {Kann, O. and Almouhanna, F. and Chausse, B.},
  title   = {{Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration}},
  journal = {Trends in neurosciences},
  year    = {2022},
  doi     = {10.1016/j.tins.2022.10.007},
  pmid    = {36283867},
  url     = {https://doi.org/10.1016/j.tins.2022.10.007}
}

@article{jin2022-35803230,
  author  = {Jin, M. and Xu, R. and Wang, L. and Alam, M. M. and Ma, Z. and Zhu, S. and Martini, A. C. and Jadali, A. and others},
  title   = {{Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease}},
  journal = {Cell stem cell},
  year    = {2022},
  doi     = {10.1016/j.stem.2022.06.007},
  pmid    = {35803230},
  url     = {https://doi.org/10.1016/j.stem.2022.06.007}
}

@article{ting2009-20003262,
  author  = {Ting, Ka Ka and Brew, Bruce James and Guillemin, Gilles J.},
  title   = {{Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease}},
  journal = {Journal of Neuroinflammation},
  year    = {2009},
  doi     = {10.1186/1742-2094-6-36},
  pmid    = {20003262},
  url     = {https://doi.org/10.1186/1742-2094-6-36}
}

@article{bazan2008-19018037,
  author  = {Bazan, Nicolas Guillermo},
  title   = {{Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease}},
  journal = {Journal of Lipid Research},
  year    = {2008},
  doi     = {10.1194/jlr.r800068-jlr200},
  pmid    = {19018037},
  url     = {https://doi.org/10.1194/jlr.r800068-jlr200}
}

@article{hofman1989-2754393,
  author  = {Hofman, Florence M. and Hinton, David R. and Johnson, K. P. and Merrill, J E},
  title   = {{Tumor necrosis factor identified in multiple sclerosis brain}},
  journal = {The Journal of Experimental Medicine},
  year    = {1989},
  doi     = {10.1084/jem.170.2.607},
  pmid    = {2754393},
  url     = {https://doi.org/10.1084/jem.170.2.607}
}

@article{cunningham2005-16207887,
  author  = {Cunningham, Colm M. and Wilcockson, David Charles and Campion, Suzanne and Lunnon, Katie and Perry, Victor Hugh},
  title   = {{Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration}},
  journal = {Journal of Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2614-05.2005},
  pmid    = {16207887},
  url     = {https://doi.org/10.1523/jneurosci.2614-05.2005}
}

@article{frankcannon2009-19917131,
  author  = {Frank-Cannon, Tamy C. and Alto, Laura Taylor and McAlpine, Fiona E and Tansey, Malú G.},
  title   = {{Does neuroinflammation fan the flame in neurodegenerative diseases?}},
  journal = {Molecular Neurodegeneration},
  year    = {2009},
  doi     = {10.1186/1750-1326-4-47},
  pmid    = {19917131},
  url     = {https://doi.org/10.1186/1750-1326-4-47}
}

@article{selmaj1991-1999503,
  author  = {Selmaj, Krzysztof W. and Raine, Cedric S. and Cannella, Barbara and Brosnan, Celia F.},
  title   = {{Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions}},
  journal = {Journal of Clinical Investigation},
  year    = {1991},
  doi     = {10.1172/jci115102},
  pmid    = {1999503},
  url     = {https://doi.org/10.1172/jci115102}
}

@article{combs2001-11160388,
  author  = {Combs, Colin Kelly and Karlo, J. Colleen and Kao, Shih-Chu and Landreth, Gary E.},
  title   = {{β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis}},
  journal = {Journal of Neuroscience},
  year    = {2001},
  doi     = {10.1523/jneurosci.21-04-01179.2001},
  pmid    = {11160388},
  url     = {https://doi.org/10.1523/jneurosci.21-04-01179.2001}
}

@article{paresce1996-8816718,
  author  = {Paresce, Donata M. and Ghosh, Richik N. and Maxfield, Frederick R.},
  title   = {{Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor}},
  journal = {Neuron},
  year    = {1996},
  doi     = {10.1016/s0896-6273(00)80187-7},
  pmid    = {8816718},
  url     = {https://doi.org/10.1016/s0896-6273(00)80187-7}
}

@article{chiu2013-23850290,
  author  = {Chiu, Isaac M. and Morimoto, Emiko and Goodarzi, Hani and Liao, Jennifer T. and O’Keeffe, Sean and Phatnani, Hemali P. and Muratet, Michael A. and Carroll, Michael C. and others},
  title   = {{A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model}},
  journal = {Cell Reports},
  year    = {2013},
  doi     = {10.1016/j.celrep.2013.06.018},
  pmid    = {23850290},
  url     = {https://doi.org/10.1016/j.celrep.2013.06.018}
}

@article{benito2003-14657172,
  author  = {Benito, Cristina and Núñez, Estefanía and Tolón, Rosa Maria and Carrier, Erica J. and Rábano, Alberto and Hillard, Cecilia J. and Romero, Julián},
  title   = {{Cannabinoid CB2Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains}},
  journal = {Journal of Neuroscience},
  year    = {2003},
  doi     = {10.1523/jneurosci.23-35-11136.2003},
  pmid    = {14657172},
  url     = {https://doi.org/10.1523/jneurosci.23-35-11136.2003}
}

@article{frautschy1998-9422548,
  author  = {Frautschy, Sally Ann and Yang, F and Irrizarry, Michael and Hyman, Bradley T. and Saido, Takaomi C. and Hsiao, Karen and Cole, Greg M.},
  title   = {{Microglial response to amyloid plaques in APPsw transgenic mice}},
  journal = {Europe PMC (PubMed Central)},
  year    = {1998},
  pmid    = {9422548}
}

@article{lian2016-26758846,
  author  = {Lian, Hong and Litvinchuk, Alexandra and Chiang, Angie C.A. and Aithmitti, Nadia and Jankowsky, Joanna L. and Zheng, Hui},
  title   = {{Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease}},
  journal = {Journal of Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.2117-15.2016},
  pmid    = {26758846},
  url     = {https://doi.org/10.1523/jneurosci.2117-15.2016}
}

@article{reedgeaghan2009-19776284,
  author  = {Reed-Geaghan, Erin G. and Savage, Julie C. and Hise, Amy G. and Landreth, Gary E.},
  title   = {{CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation}},
  journal = {Journal of Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.3158-09.2009},
  pmid    = {19776284},
  url     = {https://doi.org/10.1523/jneurosci.3158-09.2009}
}

@article{takatori2019-30747419,
  author  = {Takatori, Sho and Wang, Wenbo and Iguchi, Akihiro and Tomita, Taisuke},
  title   = {{Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms}},
  journal = {Advances in experimental medicine and biology},
  year    = {2019},
  doi     = {10.1007/978-3-030-05542-4_5},
  pmid    = {30747419},
  url     = {https://doi.org/10.1007/978-3-030-05542-4_5}
}

@article{deming2018-29889572,
  author  = {Deming, Yuetiva and Li, Zeran and Benitez, Bruno A and Cruchaga, Carlos},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?}},
  journal = {Expert opinion on therapeutic targets},
  year    = {2018},
  doi     = {10.1080/14728222.2018.1486823},
  pmid    = {29889572},
  url     = {https://doi.org/10.1080/14728222.2018.1486823}
}

@article{han2017-27871212,
  author  = {Han, Jie and Wang, Miaomiao and Ren, Manru and Lou, Haiyan},
  title   = {{Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases}},
  journal = {The International journal of neuroscience},
  year    = {2017},
  doi     = {10.1080/00207454.2016.1264072},
  pmid    = {27871212},
  url     = {https://doi.org/10.1080/00207454.2016.1264072}
}

@article{zhang2017-29180839,
  author  = {Zhang, Xiaobao and Yan, Fang and Cui, Jizheng and Wu, Yong and Luan, Hengfei and Yin, Miaomiao and Zhao, Zhibin and Feng, Jiying and others},
  title   = {{Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia}},
  journal = {Mediators of inflammation},
  year    = {2017},
  doi     = {10.1155/2017/9340610},
  pmid    = {29180839},
  url     = {https://doi.org/10.1155/2017/9340610}
}

@article{gussago2019-30997915,
  author  = {Gussago, C and Casati, M and Ferri, E and Arosio, B},
  title   = {{The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore}},
  journal = {The Journal of frailty \& aging},
  year    = {2019},
  doi     = {10.14283/jfa.2018.43},
  pmid    = {30997915},
  url     = {https://doi.org/10.14283/jfa.2018.43}
}

@article{qin2020-32412103,
  author  = {Qin, Zhangjin and Gu, Min and Zhou, Jian and Zhang, Wenbo and Zhao, Nan and Lü, Yang and Yu, Weihua},
  title   = {{Triggering receptor expressed on myeloid cells 2 activation downregulates toll-like receptor 4 expression and ameliorates cognitive impairment in the Aβ1-42 -induced Alzheimer's disease mouse model}},
  journal = {Synapse (New York, N.Y.)},
  year    = {2020},
  doi     = {10.1002/syn.22161},
  pmid    = {32412103},
  url     = {https://doi.org/10.1002/syn.22161}
}

@article{gao2017-28393702,
  author  = {Gao, Li and Jiang, Teng and Yao, Xiaoying and Yu, Ling and Yang, Xiaolan and Li, Yansheng},
  title   = {{TREM2 and the Progression of Alzheimer's Disease}},
  journal = {Current neurovascular research},
  year    = {2017},
  doi     = {10.2174/1567202614666170404165201},
  pmid    = {28393702},
  url     = {https://doi.org/10.2174/1567202614666170404165201}
}

@article{karanfilian2020-31727362,
  author  = {Karanfilian, Lucine and Tosto, Maria Grazia and Malki, Karim},
  title   = {{The role of TREM2 in Alzheimer's disease; evidence from transgenic mouse models}},
  journal = {Neurobiology of aging},
  year    = {2020},
  doi     = {10.1016/j.neurobiolaging.2019.09.004},
  pmid    = {31727362},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2019.09.004}
}

@article{wang2020-32617097,
  author  = {Wang, Qian and Yang, Weixia and Zhang, Jingmei and Zhao, Yueran and Xu, Yuzhen},
  title   = {{TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia}},
  journal = {Neural plasticity},
  year    = {2020},
  doi     = {10.1155/2020/8834275},
  pmid    = {32617097},
  url     = {https://doi.org/10.1155/2020/8834275}
}

@article{berner2020-32237095,
  author  = {Berner, Dennis Kristopher and Wessolowski, Luisa and Armbrust, Fred and Schneppenheim, Janna and Schlepckow, Kai and Koudelka, Tomas and Scharfenberg, Franka and Lucius, Ralph and others},
  title   = {{Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2020},
  doi     = {10.1096/fj.201902183r},
  pmid    = {32237095},
  url     = {https://doi.org/10.1096/fj.201902183r}
}

@article{jiang2017-26780455,
  author  = {Jiang, Teng and Wan, Yu and Zhang, Ying-Dong and Zhou, Jun-Shan and Gao, Qing and Zhu, Xi-Chen and Shi, Jian-Quan and Lu, Huan and others},
  title   = {{TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice}},
  journal = {Molecular neurobiology},
  year    = {2017},
  doi     = {10.1007/s12035-016-9704-x},
  pmid    = {26780455},
  url     = {https://doi.org/10.1007/s12035-016-9704-x}
}

@article{olsen2020-33062201,
  author  = {Olsen, Ingar and Singhrao, Sim K},
  title   = {{Interaction between genetic factors, Porphyromonas gingivalis and microglia to promote Alzheimer's disease}},
  journal = {Journal of oral microbiology},
  year    = {2020},
  doi     = {10.1080/20002297.2020.1820834},
  pmid    = {33062201},
  url     = {https://doi.org/10.1080/20002297.2020.1820834}
}

@article{zhong2019-32038221,
  author  = {Zhong, Li and Chen, Xiao-Fen},
  title   = {{The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2019},
  doi     = {10.3389/fnagi.2019.00328},
  pmid    = {32038221},
  url     = {https://doi.org/10.3389/fnagi.2019.00328}
}

@article{kim2019-31297134,
  author  = {Kim, Seung Hyun and Noh, Min Young and Kim, Hee-Jin and Oh, Ki-Wook and Park, Jinseok and Lee, Sanggon and Moon, Yeonsil and Kim, Young-Eun and others},
  title   = {{A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation}},
  journal = {Dementia and neurocognitive disorders},
  year    = {2019},
  doi     = {10.12779/dnd.2019.18.2.33},
  pmid    = {31297134},
  url     = {https://doi.org/10.12779/dnd.2019.18.2.33}
}

@article{fung2020-32741831,
  author  = {Fung, Susan and Smith, Carole L and Prater, Katherine E and Case, Amanda and Green, Kevin and Osnis, Leah and Winston, Chloe and Kinoshita, Yoshito and others},
  title   = {{Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200492},
  pmid    = {32741831},
  url     = {https://doi.org/10.3233/jad-200492}
}

@article{edison2020-32739010,
  author  = {Edison, Paul},
  title   = {{Neuroinflammation, microglial activation, and glucose metabolism in neurodegenerative diseases}},
  journal = {International review of neurobiology},
  year    = {2020},
  doi     = {10.1016/bs.irn.2020.03.017},
  pmid    = {32739010},
  url     = {https://doi.org/10.1016/bs.irn.2020.03.017}
}

@article{venegas2019-31702392,
  author  = {Venegas, Carmen and Heneka, Michael T},
  title   = {{Inflammasome-mediated innate immunity in Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900439},
  pmid    = {31702392},
  url     = {https://doi.org/10.1096/fj.201900439}
}

@article{pereira2019-31577960,
  author  = {Pereira, Claudia F and Santos, Armanda E and Moreira, Paula I and Pereira, Ana Catarina and Sousa, Fabio J and Cardoso, Sandra M and Cruz, M Teresa},
  title   = {{Is Alzheimer's disease an inflammasomopathy?}},
  journal = {Ageing research reviews},
  year    = {2019},
  doi     = {10.1016/j.arr.2019.100966},
  pmid    = {31577960},
  url     = {https://doi.org/10.1016/j.arr.2019.100966}
}

@article{heneka2017-28019679,
  author  = {Heneka, Michael T},
  title   = {{Inflammasome activation and innate immunity in Alzheimer's disease}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2017},
  doi     = {10.1111/bpa.12483},
  pmid    = {28019679},
  url     = {https://doi.org/10.1111/bpa.12483}
}

@article{giorgi2020-33207731,
  author  = {Giorgi, Filippo Sean and Biagioni, Francesca and Galgani, Alessandro and Pavese, Nicola and Lazzeri, Gloria and Fornai, Francesco},
  title   = {{Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21228630},
  pmid    = {33207731},
  url     = {https://doi.org/10.3390/ijms21228630}
}

@article{dinet2019-31780883,
  author  = {Dinet, Virginie and Petry, Klaus G and Badaut, Jerome},
  title   = {{Brain-Immune Interactions and Neuroinflammation After Traumatic Brain Injury}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.01178},
  pmid    = {31780883},
  url     = {https://doi.org/10.3389/fnins.2019.01178}
}

@article{ho2020-31786775,
  author  = {Ho, Wen-Chien and Hsu, Chia-Chi and Huang, Hui-Ju and Wang, Hsiang-Tsui and Lin, Anya Maan-Yuh},
  title   = {{Anti-inflammatory Effect of AZD6244 on Acrolein-Induced Neuroinflammation}},
  journal = {Molecular neurobiology},
  year    = {2020},
  doi     = {10.1007/s12035-019-01758-8},
  pmid    = {31786775},
  url     = {https://doi.org/10.1007/s12035-019-01758-8}
}

@article{tzeng2018-30127003,
  author  = {Tzeng, Te-Chen and Hasegawa, Yuto and Iguchi, Risa and Cheung, Amy and Caffrey, Daniel R and Thatcher, Elizabeth Jeanne and Mao, Wenjie and Germain, Gail and others},
  title   = {{Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2018},
  doi     = {10.1073/pnas.1801802115},
  pmid    = {30127003},
  url     = {https://doi.org/10.1073/pnas.1801802115}
}

@article{pennisi2017-27862176,
  author  = {Pennisi, Manuela and Crupi, Rosalia and Di Paola, Rosanna and Ontario, Maria Laura and Bella, Rita and Calabrese, Edward J and Crea, Roberto and Cuzzocrea, Salvatore and others},
  title   = {{Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease}},
  journal = {Journal of neuroscience research},
  year    = {2017},
  doi     = {10.1002/jnr.23986},
  pmid    = {27862176},
  url     = {https://doi.org/10.1002/jnr.23986}
}

@article{marttinen2018-30618585,
  author  = {Marttinen, Mikael and Takalo, Mari and Natunen, Teemu and Wittrahm, Rebekka and Gabbouj, Sami and Kemppainen, Susanna and Leinonen, Ville and Tanila, Heikki and others},
  title   = {{Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease}},
  journal = {Frontiers in neuroscience},
  year    = {2018},
  doi     = {10.3389/fnins.2018.00963},
  pmid    = {30618585},
  url     = {https://doi.org/10.3389/fnins.2018.00963}
}

@article{meszaros2020-32635451,
  author  = {Mészáros, Ádám and Molnár, Kinga and Nógrádi, Bernát and Hernádi, Zsófia and Nyúl-Tóth, Ádám and Wilhelm, Imola and Krizbai, István A},
  title   = {{Neurovascular Inflammaging in Health and Disease}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9071614},
  pmid    = {32635451},
  url     = {https://doi.org/10.3390/cells9071614}
}

@article{dansokho2018-29273951,
  author  = {Dansokho, Cira and Heneka, Michael Thomas},
  title   = {{Neuroinflammatory responses in Alzheimer's disease}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2018},
  doi     = {10.1007/s00702-017-1831-7},
  pmid    = {29273951},
  url     = {https://doi.org/10.1007/s00702-017-1831-7}
}

@article{guan2020-32792920,
  author  = {Guan, Yadi and Han, Fang},
  title   = {{Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases}},
  journal = {Frontiers in integrative neuroscience},
  year    = {2020},
  doi     = {10.3389/fnint.2020.00037},
  pmid    = {32792920},
  url     = {https://doi.org/10.3389/fnint.2020.00037}
}

@article{larosa2019-31594217,
  author  = {La Rosa, Francesca and Saresella, Marina and Marventano, Ivana and Piancone, Federica and Ripamonti, Enrico and Al-Daghri, Nasser and Bazzini, Chiara and Zoia, Chiara Paola and others},
  title   = {{Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-181259},
  pmid    = {31594217},
  url     = {https://doi.org/10.3233/jad-181259}
}

@article{yang2020-32391019,
  author  = {Yang, Junling and Wise, Leslie and Fukuchi, Ken-Ichiro},
  title   = {{TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.00724},
  pmid    = {32391019},
  url     = {https://doi.org/10.3389/fimmu.2020.00724}
}

@article{matsuda2015-ebf754c6,
  author  = {Matsuda, Taito and Murao, Naoya and Katano, Yuki and Juliandi, Berry and Kohyama, Jun and Akira, Shizuo and Kawai, Taro and Nakashima, Kinichi},
  title   = {{TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus}},
  journal = {Nature Communications},
  year    = {2015},
  doi     = {10.1038/ncomms7514},
  url     = {https://doi.org/10.1038/ncomms7514}
}

@article{dempsey2017-28003153,
  author  = {Dempsey, C. and Rubio Araiz, A. and Bryson, K. J. and Finucane, O. and Larkin, C. and Mills, E. L. and Robertson, A. A. B. and Cooper, M. A. and others},
  title   = {{Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2017},
  doi     = {10.1016/j.bbi.2016.12.014},
  pmid    = {28003153},
  url     = {https://doi.org/10.1016/j.bbi.2016.12.014}
}

@article{mcintosh2019-30661261,
  author  = {McIntosh, A. and Mela, V. and Harty, C. and Minogue, A. M. and Costello, D. A. and Kerskens, C. and Lynch, M. A.},
  title   = {{Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2019},
  doi     = {10.1111/bpa.12704},
  pmid    = {30661261},
  url     = {https://doi.org/10.1111/bpa.12704}
}

@article{mrdjen2018-29426702,
  author  = {Mrdjen, D. and Pavlovic, A. and Hartmann, F. J. and Schreiner, B. and Utz, S. G. and Leung, B. P. and Lelios, I. and Heppner, F. L. and others},
  title   = {{High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease}},
  journal = {Immunity},
  year    = {2018},
  doi     = {10.1016/j.immuni.2018.01.011},
  pmid    = {29426702},
  url     = {https://doi.org/10.1016/j.immuni.2018.01.011}
}

@article{litvinchuk2018-30415998,
  author  = {Litvinchuk, A. and Wan, Y. W. and Swartzlander, D. B. and Chen, F. and Cole, A. and Propson, N. E. and Wang, Q. and Zhang, B. and others},
  title   = {{Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.10.031},
  pmid    = {30415998},
  url     = {https://doi.org/10.1016/j.neuron.2018.10.031}
}

@article{geirsdottir2019-31835035,
  author  = {Geirsdottir, L. and David, E. and Keren-Shaul, H. and Weiner, A. and Bohlen, S. C. and Neuber, J. and Balic, A. and Giladi, A. and others},
  title   = {{Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program}},
  journal = {Cell},
  year    = {2019},
  doi     = {10.1016/j.cell.2019.11.010},
  pmid    = {31835035},
  url     = {https://doi.org/10.1016/j.cell.2019.11.010}
}

@article{williams2017-28242160,
  author  = {Williams, P. A. and Marsh-Armstrong, N. and Howell, G. R. and {Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants}},
  title   = {{Neuroinflammation in glaucoma: A new opportunity}},
  journal = {Experimental eye research},
  year    = {2017},
  doi     = {10.1016/j.exer.2017.02.014},
  pmid    = {28242160},
  url     = {https://doi.org/10.1016/j.exer.2017.02.014}
}

@article{thawkar2019-30502599,
  author  = {Thawkar, B. S. and Kaur, G.},
  title   = {{Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease}},
  journal = {Journal of neuroimmunology},
  year    = {2019},
  doi     = {10.1016/j.jneuroim.2018.11.010},
  pmid    = {30502599},
  url     = {https://doi.org/10.1016/j.jneuroim.2018.11.010}
}

@article{lee2018-28456941,
  author  = {Lee, C. H. and Jeon, S. J. and Cho, K. S. and Moon, E. and Sapkota, A. and Jun, H. S. and Ryu, J. H. and Choi, J. W.},
  title   = {{Activation of Glucagon-Like Peptide-1 Receptor Promotes Neuroprotection in Experimental Autoimmune Encephalomyelitis by Reducing Neuroinflammatory Responses}},
  journal = {Molecular neurobiology},
  year    = {2018},
  doi     = {10.1007/s12035-017-0550-2},
  pmid    = {28456941},
  url     = {https://doi.org/10.1007/s12035-017-0550-2}
}

@article{madore2020-31924476,
  author  = {Madore, C. and Yin, Z. and Leibowitz, J. and Butovsky, O.},
  title   = {{Microglia, Lifestyle Stress, and Neurodegeneration}},
  journal = {Immunity},
  year    = {2020},
  doi     = {10.1016/j.immuni.2019.12.003},
  pmid    = {31924476},
  url     = {https://doi.org/10.1016/j.immuni.2019.12.003}
}

@article{rajendran2018-29563239,
  author  = {Rajendran, L. and Paolicelli, R. C.},
  title   = {{Microglia-Mediated Synapse Loss in Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2018},
  doi     = {10.1523/jneurosci.1136-17.2017},
  pmid    = {29563239},
  url     = {https://doi.org/10.1523/jneurosci.1136-17.2017}
}

@article{abud2017-28426964,
  author  = {Abud, E. M. and Ramirez, R. N. and Martinez, E. S. and Healy, L. M. and Nguyen, C. H. H. and Newman, S. A. and Yeromin, A. V. and Scarfone, V. M. and others},
  title   = {{iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.03.042},
  pmid    = {28426964},
  url     = {https://doi.org/10.1016/j.neuron.2017.03.042}
}

@article{stephenson2018-29513402,
  author  = {Stephenson, J. and Nutma, E. and van der Valk, P. and Amor, S.},
  title   = {{Inflammation in CNS neurodegenerative diseases}},
  journal = {Immunology},
  year    = {2018},
  doi     = {10.1111/imm.12922},
  pmid    = {29513402},
  url     = {https://doi.org/10.1111/imm.12922}
}

@article{baik2019-31257151,
  author  = {Baik, S. H. and Kang, S. and Lee, W. and Choi, H. and Chung, S. and Kim, J. I. and Mook-Jung, I.},
  title   = {{A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease}},
  journal = {Cell metabolism},
  year    = {2019},
  doi     = {10.1016/j.cmet.2019.06.005},
  pmid    = {31257151},
  url     = {https://doi.org/10.1016/j.cmet.2019.06.005}
}

@article{subhramanyam2019-31077796,
  author  = {Subhramanyam, C. S. and Wang, C. and Hu, Q. and Dheen, S. T.},
  title   = {{Microglia-mediated neuroinflammation in neurodegenerative diseases}},
  journal = {Seminars in cell \& developmental biology},
  year    = {2019},
  doi     = {10.1016/j.semcdb.2019.05.004},
  pmid    = {31077796},
  url     = {https://doi.org/10.1016/j.semcdb.2019.05.004}
}

@article{varatharaj2017-26995317,
  author  = {Varatharaj, A. and Galea, I.},
  title   = {{The blood-brain barrier in systemic inflammation}},
  journal = {Brain, behavior, and immunity},
  year    = {2017},
  doi     = {10.1016/j.bbi.2016.03.010},
  pmid    = {26995317},
  url     = {https://doi.org/10.1016/j.bbi.2016.03.010}
}

@article{shi2017-28566429,
  author  = {Shi, Q. and Chowdhury, S. and Ma, R. and Le, K. X. and Hong, S. and Caldarone, B. J. and others},
  title   = {{Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice}},
  journal = {Science translational medicine},
  year    = {2017},
  doi     = {10.1126/scitranslmed.aaf6295},
  pmid    = {28566429},
  url     = {https://doi.org/10.1126/scitranslmed.aaf6295}
}

@article{michetti2019-30144068,
  author  = {Michetti, F. and D'Ambrosi, N. and Toesca, A. and Puglisi, M. A. and Serrano, A. and Marchese, E. and Corvino, V. and Geloso, M. C.},
  title   = {{The S100B story: from biomarker to active factor in neural injury}},
  journal = {Journal of neurochemistry},
  year    = {2019},
  doi     = {10.1111/jnc.14574},
  pmid    = {30144068},
  url     = {https://doi.org/10.1111/jnc.14574}
}

@article{maezawa2006-16603079,
  author  = {Maezawa, Izumi and Maeda, Nobuyo and Montine, Thomas J and Montine, Kathleen S},
  title   = {{Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-10},
  pmid    = {16603079},
  url     = {https://doi.org/10.1186/1742-2094-3-10}
}

@article{zhu2015-25816748,
  author  = {Zhu, Caihong and Herrmann, Uli S and Li, Bei and Abakumova, Irina and Moos, Rita and Schwarz, Petra and Rushing, Elisabeth J and Colonna, Marco and others},
  title   = {{Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2015.02.019},
  pmid    = {25816748},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.02.019}
}

@article{rohn2013-23533697,
  author  = {Rohn, Troy T},
  title   = {{The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer's disease}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2013},
  doi     = {10.1155/2013/860959},
  pmid    = {23533697},
  url     = {https://doi.org/10.1155/2013/860959}
}

@article{glebov2016-26792193,
  author  = {Glebov, Konstantin and Wunderlich, Patrick and Karaca, Ilker and Walter, Jochen},
  title   = {{Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)}},
  journal = {Journal of neuroinflammation},
  year    = {2016},
  doi     = {10.1186/s12974-016-0479-9},
  pmid    = {26792193},
  url     = {https://doi.org/10.1186/s12974-016-0479-9}
}

@article{li2015-25593125,
  author  = {Li, Xianwu and Montine, Kathleen S and Keene, C Dirk and Montine, Thomas J},
  title   = {{Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2015},
  doi     = {10.1096/fj.14-262683},
  pmid    = {25593125},
  url     = {https://doi.org/10.1096/fj.14-262683}
}

@article{mcgeer2000-10961418,
  author  = {McGeer, P L and McGeer, E G and Yasojima, K},
  title   = {{Alzheimer disease and neuroinflammation}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {2000},
  doi     = {10.1007/978-3-7091-6781-6_8},
  pmid    = {10961418},
  url     = {https://doi.org/10.1007/978-3-7091-6781-6_8}
}

@article{saresella2016-26939933,
  author  = {Saresella, Marina and La Rosa, Francesca and Piancone, Federica and Zoppis, Martina and Marventano, Ivana and Calabrese, Elena and Rainone, Veronica and Nemni, Raffaello and others},
  title   = {{The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0088-1},
  pmid    = {26939933},
  url     = {https://doi.org/10.1186/s13024-016-0088-1}
}

@article{melah2016-26836182,
  author  = {Melah, K. E. and Lu, S. Y. and Hoscheidt, S. M. and Alexander, A. L. and Adluru, N. and Destiche, D. J. and Carlsson, C. M. and Zetterberg, H. and others},
  title   = {{Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2016},
  doi     = {10.3233/jad-150897},
  pmid    = {26836182},
  url     = {https://doi.org/10.3233/jad-150897}
}

@article{eng1994-7952264,
  author  = {Eng, L. F. and Ghirnikar, R. S.},
  title   = {{GFAP and astrogliosis}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {1994},
  doi     = {10.1111/j.1750-3639.1994.tb00838.x},
  pmid    = {7952264},
  url     = {https://doi.org/10.1111/j.1750-3639.1994.tb00838.x}
}

@article{lim2000-10908610,
  author  = {Lim, G. P. and Yang, F. and Chu, T. and Chen, P. and Beech, W. and Teter, B. and Tran, T. and Ubeda, O. and others},
  title   = {{Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2000},
  doi     = {10.1523/jneurosci.20-15-05709.2000},
  pmid    = {10908610},
  url     = {https://doi.org/10.1523/jneurosci.20-15-05709.2000}
}

@article{hofman1986-3082983,
  author  = {Hofman, F. M. and von Hanwehr, R. I. and Dinarello, C. A. and Mizel, S. B. and Hinton, D. and Merrill, J. E.},
  title   = {{Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {1986},
  doi     = {10.4049/jimmunol.136.9.3239},
  pmid    = {3082983},
  url     = {https://doi.org/10.4049/jimmunol.136.9.3239}
}

@article{stephenson1996-9173912,
  author  = {Stephenson, D. T. and Lemere, C. A. and Selkoe, D. J. and Clemens, J. A.},
  title   = {{Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain}},
  journal = {Neurobiology of disease},
  year    = {1996},
  doi     = {10.1006/nbdi.1996.0005},
  pmid    = {9173912},
  url     = {https://doi.org/10.1006/nbdi.1996.0005}
}

@article{blumdegen1995-8787820,
  author  = {Blum-Degen, D. and Müller, T. and Kuhn, W. and Gerlach, M. and Przuntek, H. and Riederer, P.},
  title   = {{Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients}},
  journal = {Neuroscience letters},
  year    = {1995},
  doi     = {10.1016/0304-3940(95)12192-7},
  pmid    = {8787820},
  url     = {https://doi.org/10.1016/0304-3940(95)12192-7}
}

@article{ling1993-8423067,
  author  = {Ling, E. A. and Wong, W. C.},
  title   = {{The origin and nature of ramified and amoeboid microglia: a historical review and current concepts}},
  journal = {Glia},
  year    = {1993},
  doi     = {10.1002/glia.440070105},
  pmid    = {8423067},
  url     = {https://doi.org/10.1002/glia.440070105}
}

@article{conant1998-9501225,
  author  = {Conant, K. and Garzino-Demo, A. and Nath, A. and McArthur, J. C. and Halliday, W. and Power, C. and Gallo, R. C. and Major, E. O.},
  title   = {{Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1998},
  doi     = {10.1073/pnas.95.6.3117},
  pmid    = {9501225},
  url     = {https://doi.org/10.1073/pnas.95.6.3117}
}

@article{hong2016-26745839,
  author  = {Hong, S. and Dissing-Olesen, L. and Stevens, B.},
  title   = {{New insights on the role of microglia in synaptic pruning in health and disease}},
  journal = {Current opinion in neurobiology},
  year    = {2016},
  doi     = {10.1016/j.conb.2015.12.004},
  pmid    = {26745839},
  url     = {https://doi.org/10.1016/j.conb.2015.12.004}
}

@article{kitazawa2005-16192374,
  author  = {Kitazawa, M. and Oddo, S. and Yamasaki, T. R. and Green, K. N. and LaFerla, F. M.},
  title   = {{Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2868-05.2005},
  pmid    = {16192374},
  url     = {https://doi.org/10.1523/jneurosci.2868-05.2005}
}

@article{pekny2014-24406153,
  author  = {Pekny, M. and Wilhelmsson, U. and Pekna, M.},
  title   = {{The dual role of astrocyte activation and reactive gliosis}},
  journal = {Neuroscience letters},
  year    = {2014},
  doi     = {10.1016/j.neulet.2013.12.071},
  pmid    = {24406153},
  url     = {https://doi.org/10.1016/j.neulet.2013.12.071}
}

@article{rothaug2016-27016501,
  author  = {Rothaug, M. and Becker-Pauly, C. and Rose-John, S.},
  title   = {{The role of interleukin-6 signaling in nervous tissue}},
  journal = {Biochimica et biophysica acta},
  year    = {2016},
  doi     = {10.1016/j.bbamcr.2016.03.018},
  pmid    = {27016501},
  url     = {https://doi.org/10.1016/j.bbamcr.2016.03.018}
}

@article{husemann2002-12379907,
  author  = {Husemann, J. and Loike, J. D. and Anankov, R. and Febbraio, M. and Silverstein, S. C.},
  title   = {{Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system}},
  journal = {Glia},
  year    = {2002},
  doi     = {10.1002/glia.10148},
  pmid    = {12379907},
  url     = {https://doi.org/10.1002/glia.10148}
}

@article{nakazawa2007-17284607,
  author  = {Nakazawa, T. and Hisatomi, T. and Nakazawa, C. and Noda, K. and Maruyama, K. and She, H. and Matsubara, A. and Miyahara, S. and others},
  title   = {{Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2007},
  doi     = {10.1073/pnas.0608167104},
  pmid    = {17284607},
  url     = {https://doi.org/10.1073/pnas.0608167104}
}

@article{rosenberg2005-16401549,
  author  = {Rosenberg, P. B.},
  title   = {{Clinical aspects of inflammation in Alzheimer's disease}},
  journal = {International review of psychiatry (Abingdon, England)},
  year    = {2005},
  doi     = {10.1080/02646830500382037},
  pmid    = {16401549},
  url     = {https://doi.org/10.1080/02646830500382037}
}

@article{lukiw2008-18801740,
  author  = {Lukiw, W. J. and Zhao, Y. and Cui, J. G.},
  title   = {{An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m805371200},
  pmid    = {18801740},
  url     = {https://doi.org/10.1074/jbc.m805371200}
}

@article{floden2005-15758166,
  author  = {Floden, A. M. and Li, S. and Combs, C. K.},
  title   = {{Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.4998-04.2005},
  pmid    = {15758166},
  url     = {https://doi.org/10.1523/jneurosci.4998-04.2005}
}

@article{ghosh2009-19864567,
  author  = {Ghosh, A. and Roy, A. and Matras, J. and Brahmachari, S. and Gendelman, H. E. and Pahan, K.},
  title   = {{Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.4144-09.2009},
  pmid    = {19864567},
  url     = {https://doi.org/10.1523/jneurosci.4144-09.2009}
}

@article{rothwell2000-11137152,
  author  = {Rothwell, N. J. and Luheshi, G. N.},
  title   = {{Interleukin 1 in the brain: biology, pathology and therapeutic target}},
  journal = {Trends in neurosciences},
  year    = {2000},
  doi     = {10.1016/s0166-2236(00)01661-1},
  pmid    = {11137152},
  url     = {https://doi.org/10.1016/s0166-2236(00)01661-1}
}

@article{sims2010-20192808,
  author  = {Sims, G. P. and Rowe, D. C. and Rietdijk, S. T. and Herbst, R. and Coyle, A. J.},
  title   = {{HMGB1 and RAGE in inflammation and cancer}},
  journal = {Annual review of immunology},
  year    = {2010},
  doi     = {10.1146/annurev.immunol.021908.132603},
  pmid    = {20192808},
  url     = {https://doi.org/10.1146/annurev.immunol.021908.132603}
}

@article{yirmiya2015-26442697,
  author  = {Yirmiya, R. and Rimmerman, N. and Reshef, R.},
  title   = {{Depression as a microglial disease}},
  journal = {Trends in neurosciences},
  year    = {2015},
  doi     = {10.1016/j.tins.2015.08.001},
  pmid    = {26442697},
  url     = {https://doi.org/10.1016/j.tins.2015.08.001}
}

@article{mcafoose2009-18996146,
  author  = {McAfoose, J. and Baune, B. T.},
  title   = {{Evidence for a cytokine model of cognitive function}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2009},
  doi     = {10.1016/j.neubiorev.2008.10.005},
  pmid    = {18996146},
  url     = {https://doi.org/10.1016/j.neubiorev.2008.10.005}
}

@article{rogers2007-17678964,
  author  = {Rogers, J. and Mastroeni, D. and Leonard, B. and Joyce, J. and Grover, A.},
  title   = {{Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder?}},
  journal = {International review of neurobiology},
  year    = {2007},
  doi     = {10.1016/s0074-7742(07)82012-5},
  pmid    = {17678964},
  url     = {https://doi.org/10.1016/s0074-7742(07)82012-5}
}

@article{alvarezerviti2011-21423189,
  author  = {Alvarez-Erviti, L. and Seow, Y. and Yin, H. and Betts, C. and Lakhal, S. and Wood, M. J.},
  title   = {{Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes}},
  journal = {Nature biotechnology},
  year    = {2011},
  doi     = {10.1038/nbt.1807},
  pmid    = {21423189},
  url     = {https://doi.org/10.1038/nbt.1807}
}

@article{glass2010-20303880,
  author  = {Glass, C. K. and Saijo, K. and Winner, B. and Marchetto, M. C. and Gage, F. H.},
  title   = {{Mechanisms underlying inflammation in neurodegeneration}},
  journal = {Cell},
  year    = {2010},
  doi     = {10.1016/j.cell.2010.02.016},
  pmid    = {20303880},
  url     = {https://doi.org/10.1016/j.cell.2010.02.016}
}

@article{halle2008-18604209,
  author  = {Halle, A. and Hornung, V. and Petzold, G. C. and Stewart, C. R. and Monks, B. G. and Reinheckel, T. and Fitzgerald, K. A. and Latz, E. and others},
  title   = {{The NALP3 inflammasome is involved in the innate immune response to amyloid-beta}},
  journal = {Nature immunology},
  year    = {2008},
  doi     = {10.1038/ni.1636},
  pmid    = {18604209},
  url     = {https://doi.org/10.1038/ni.1636}
}

@article{tang2016-25598354,
  author  = {Tang, Y. and Le, W.},
  title   = {{Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases}},
  journal = {Molecular neurobiology},
  year    = {2016},
  doi     = {10.1007/s12035-014-9070-5},
  pmid    = {25598354},
  url     = {https://doi.org/10.1007/s12035-014-9070-5}
}

@article{amor2010-20561356,
  author  = {Amor, S. and Puentes, F. and Baker, D. and van der Valk, P.},
  title   = {{Inflammation in neurodegenerative diseases}},
  journal = {Immunology},
  year    = {2010},
  doi     = {10.1111/j.1365-2567.2009.03225.x},
  pmid    = {20561356},
  url     = {https://doi.org/10.1111/j.1365-2567.2009.03225.x}
}

@article{lucas2006-16402109,
  author  = {Lucas, S. M. and Rothwell, N. J. and Gibson, R. M.},
  title   = {{The role of inflammation in CNS injury and disease}},
  journal = {British journal of pharmacology},
  year    = {2006},
  doi     = {10.1038/sj.bjp.0706400},
  pmid    = {16402109},
  url     = {https://doi.org/10.1038/sj.bjp.0706400}
}

@article{kim2015-25690731,
  author  = {Kim, E. K. and Choi, E. J.},
  title   = {{Compromised MAPK signaling in human diseases: an update}},
  journal = {Archives of toxicology},
  year    = {2015},
  doi     = {10.1007/s00204-015-1472-2},
  pmid    = {25690731},
  url     = {https://doi.org/10.1007/s00204-015-1472-2}
}

@article{liu2003-12490568,
  author  = {Liu, B. and Hong, J. S.},
  title   = {{Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention}},
  journal = {The Journal of pharmacology and experimental therapeutics},
  year    = {2003},
  doi     = {10.1124/jpet.102.035048},
  pmid    = {12490568},
  url     = {https://doi.org/10.1124/jpet.102.035048}
}

@article{wang2015-26207229,
  author  = {Wang, W. Y. and Tan, M. S. and Yu, J. T. and Tan, L.},
  title   = {{Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease}},
  journal = {Annals of translational medicine},
  year    = {2015},
  doi     = {10.3978/j.issn.2305-5839.2015.03.49},
  pmid    = {26207229},
  url     = {https://doi.org/10.3978/j.issn.2305-5839.2015.03.49}
}

@article{tansey2010-19913097,
  author  = {Tansey, M. G. and Goldberg, M. S.},
  title   = {{Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention}},
  journal = {Neurobiology of disease},
  year    = {2010},
  doi     = {10.1016/j.nbd.2009.11.004},
  pmid    = {19913097},
  url     = {https://doi.org/10.1016/j.nbd.2009.11.004}
}

@article{gonzalezscarano1999-10202538,
  author  = {González-Scarano, F. and Baltuch, G.},
  title   = {{Microglia as mediators of inflammatory and degenerative diseases}},
  journal = {Annual review of neuroscience},
  year    = {1999},
  doi     = {10.1146/annurev.neuro.22.1.219},
  pmid    = {10202538},
  url     = {https://doi.org/10.1146/annurev.neuro.22.1.219}
}

@article{boche2013-23252647,
  author  = {Boche, D. and Perry, V. H. and Nicoll, J. A.},
  title   = {{Review: activation patterns of microglia and their identification in the human brain}},
  journal = {Neuropathology and applied neurobiology},
  year    = {2013},
  doi     = {10.1111/nan.12011},
  pmid    = {23252647},
  url     = {https://doi.org/10.1111/nan.12011}
}

@article{streit2002-12379901,
  author  = {Streit, W. J.},
  title   = {{Microglia as neuroprotective, immunocompetent cells of the CNS}},
  journal = {Glia},
  year    = {2002},
  doi     = {10.1002/glia.10154},
  pmid    = {12379901},
  url     = {https://doi.org/10.1002/glia.10154}
}

@article{heneka2015-25689443,
  author  = {Heneka, M. T. and Golenbock, D. T. and Latz, E.},
  title   = {{Innate immunity in Alzheimer's disease}},
  journal = {Nature immunology},
  year    = {2015},
  doi     = {10.1038/ni.3102},
  pmid    = {25689443},
  url     = {https://doi.org/10.1038/ni.3102}
}

@article{waschek2013-23517078,
  author  = {Waschek, J. A.},
  title   = {{VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair}},
  journal = {British journal of pharmacology},
  year    = {2013},
  doi     = {10.1111/bph.12181},
  pmid    = {23517078},
  url     = {https://doi.org/10.1111/bph.12181}
}

@article{carson2006-16972896,
  author  = {Carson, M. J. and Doose, J. M. and Melchior, B. and Schmid, C. D. and Ploix, C. C.},
  title   = {{CNS immune privilege: hiding in plain sight}},
  journal = {Immunological reviews},
  year    = {2006},
  doi     = {10.1111/j.1600-065x.2006.00441.x},
  pmid    = {16972896},
  url     = {https://doi.org/10.1111/j.1600-065x.2006.00441.x}
}

@article{wysscoray2012-22315714,
  author  = {Wyss-Coray, T. and Rogers, J.},
  title   = {{Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
  doi     = {10.1101/cshperspect.a006346},
  pmid    = {22315714},
  url     = {https://doi.org/10.1101/cshperspect.a006346}
}

@article{lian2015-25533482,
  author  = {Lian, H. and Yang, L. and Cole, A. and Sun, L. and Chiang, A. C. and Fowler, S. W. and Shim, D. J. and Rodriguez-Rivera, J. and others},
  title   = {{NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease}},
  journal = {Neuron},
  year    = {2015},
  doi     = {10.1016/j.neuron.2014.11.018},
  pmid    = {25533482},
  url     = {https://doi.org/10.1016/j.neuron.2014.11.018}
}

@article{ramirez2005-15728830,
  author  = {Ramírez, B. G. and Blázquez, C. and Gómez del Pulgar, T. and Guzmán, M. and de Ceballos, M. L.},
  title   = {{Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.4540-04.2005},
  pmid    = {15728830},
  url     = {https://doi.org/10.1523/jneurosci.4540-04.2005}
}

@article{veerhuis2011-21546088,
  author  = {Veerhuis, R. and Nielsen, H. M. and Tenner, A. J.},
  title   = {{Complement in the brain}},
  journal = {Molecular immunology},
  year    = {2011},
  doi     = {10.1016/j.molimm.2011.04.003},
  pmid    = {21546088},
  url     = {https://doi.org/10.1016/j.molimm.2011.04.003}
}

@article{hein2010-19825412,
  author  = {Hein, A. M. and Stasko, M. R. and Matousek, S. B. and Scott-McKean, J. J. and Maier, S. F. and Olschowka, J. A. and Costa, A. C. and O'Banion, M. K.},
  title   = {{Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2010},
  doi     = {10.1016/j.bbi.2009.10.002},
  pmid    = {19825412},
  url     = {https://doi.org/10.1016/j.bbi.2009.10.002}
}

@article{ruan2009-19747158,
  author  = {Ruan, Lingfei and Kang, Zhoujun and Pei, Gang and Le, Yingying},
  title   = {{Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease}},
  journal = {Current Alzheimer Research},
  year    = {2009},
  doi     = {10.2174/156720509790147070},
  pmid    = {19747158},
  url     = {https://doi.org/10.2174/156720509790147070}
}

@article{lavrik2005-15654015,
  author  = {Lavrik, Inna N. and Golks, Alexander and Krammer, Peter H.},
  title   = {{Death receptor signaling}},
  journal = {Journal of Cell Science},
  year    = {2005},
  doi     = {10.1242/jcs.01610},
  pmid    = {15654015},
  url     = {https://doi.org/10.1242/jcs.01610}
}

@article{levy2015-4d2d615e,
  author  = {Levy, Olivier and Calippe, Bertrand and Lavalette, Sophie and Hu, Shulong J and Raoul, William and Dominguez, Elisa and Housset, Michael and Paques, Michel and others},
  title   = {{Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration}},
  journal = {EMBO Molecular Medicine},
  year    = {2015},
  doi     = {10.15252/emmm.201404524},
  url     = {https://doi.org/10.15252/emmm.201404524}
}

@article{elhage2015-84bbe974,
  author  = {El-Hage, Nazira and Rodriguez, Myosotys and Dever, Seth M. and Masvekar, Ruturaj R. and Gewirtz, David A. and Shacka, John J.},
  title   = {{HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse}},
  journal = {Journal of Virology},
  year    = {2015},
  doi     = {10.1128/jvi.02022-14},
  url     = {https://doi.org/10.1128/jvi.02022-14}
}

@article{carroll2015-a3cc5d37,
  author  = {Carroll, James A. and Striebel, James F. and Race, Brent and Phillips, Katie and Chesebro, Bruce},
  title   = {{Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction}},
  journal = {Journal of Virology},
  year    = {2015},
  doi     = {10.1128/jvi.02952-14},
  url     = {https://doi.org/10.1128/jvi.02952-14}
}

@article{cho2015-e082a2d8,
  author  = {Cho, Seo-Hyun and Chen, Jason A. and Sayed, Faten and Ward, Michael E. and Gao, Fuying and Nguyen, Thi A. and Krabbe, Grietje and Sohn, Peter Dongmin and others},
  title   = {{SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β}},
  journal = {The Journal of Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.2939-14.2015},
  url     = {https://doi.org/10.1523/jneurosci.2939-14.2015}
}

@article{cox2015-0d3a0b26,
  author  = {Cox, Donal J. and Field, Robert H. and Williams, David G. and Baran, Marcin and Bowie, Andrew G. and Cunningham, Colm and Dunne, Aisling},
  title   = {{DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease}},
  journal = {Glia},
  year    = {2015},
  doi     = {10.1002/glia.22786},
  url     = {https://doi.org/10.1002/glia.22786}
}

@article{haim2015-fb6262b5,
  author  = {Haim, Lucile Ben and Ceyzériat, Kelly and Sauvage, Maria Angeles Carrillo-de and Aubry, Fabien and Auregan, Gwennaëlle and Guillermier, Martine and Ruiz, Marta and Petit, Fanny and others},
  title   = {{The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases}},
  journal = {The Journal of Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.3516-14.2015},
  url     = {https://doi.org/10.1523/jneurosci.3516-14.2015}
}

@article{carretrebillat2015-79617690,
  author  = {Carret-Rebillat, Anne-Sophie and Pace, Clarisse and Gourmaud, Sarah and Ravasi, Laura and Montagne-Stora, Samantha and Longueville, Sophie and Tible, Marion and Sudol, Erika and others},
  title   = {{Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation}},
  journal = {Scientific Reports},
  year    = {2015},
  doi     = {10.1038/srep08489},
  url     = {https://doi.org/10.1038/srep08489}
}

@article{li2015-7e58f8dc,
  author  = {Li, Matthew D. and Burns, Terry C. and Kumar, Sunny and Morgan, Alexander A. and Sloan, Steven A. and Palmer, Theo D.},
  title   = {{Aging‐like changes in the transcriptome of irradiated microglia}},
  journal = {Glia},
  year    = {2015},
  doi     = {10.1002/glia.22782},
  url     = {https://doi.org/10.1002/glia.22782}
}

@article{biesmans2015-5f2cd130,
  author  = {Biesmans, Steven and Acton, Paul D. and Cotto, Carlos and Langlois, Xavier and Donck, Luc Ver and Bouwknecht, Jan A. and Aelvoet, Sarah‐Ann and Hellings, Niels and others},
  title   = {{Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap‐luc mice}},
  journal = {Glia},
  year    = {2015},
  doi     = {10.1002/glia.22804},
  url     = {https://doi.org/10.1002/glia.22804}
}

@article{brown2015-602808b8,
  author  = {Brown, Amanda},
  title   = {{Understanding the MIND phenotype: macrophage/microglia inflammation in neurocognitive disorders related to human immunodeficiency virus infection}},
  journal = {Clinical and Translational Medicine},
  year    = {2015},
  doi     = {10.1186/s40169-015-0049-2},
  url     = {https://doi.org/10.1186/s40169-015-0049-2}
}

@article{kamphuis2015-ea259c45,
  author  = {Kamphuis, Willem and Kooijman, Lieneke and Orre, Marie and Stassen, Oscar and Pekny, Milos and Hol, Elly M.},
  title   = {{GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for A lzheimer's disease}},
  journal = {Glia},
  year    = {2015},
  doi     = {10.1002/glia.22800},
  url     = {https://doi.org/10.1002/glia.22800}
}

@article{bosco2015-6869bfb1,
  author  = {Bosco, Alejandra and Romero, Cesar O. and Breen, Kevin T. and Chagovetz, Alexis A. and Steele, Michael R. and Ambati, Balamurali K. and Vetter, Monica L.},
  title   = {{Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma}},
  journal = {Disease Models \& Mechanisms},
  year    = {2015},
  doi     = {10.1242/dmm.018788},
  url     = {https://doi.org/10.1242/dmm.018788}
}

@article{abel2025-41446157,
  author  = {Abel, Tamar R and Pandey, Ravi S and Haber, Annat and Garceau, Dylan and Sasner, Michael and Kotredes, Kevin P and Cary, Gregory A and Oblak, Adrian and others},
  title   = {{Trem2R47H and reduced TREM2 expression both mimic human Alzheimer's disease signatures in mice}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.64898/2025.12.17.694758},
  pmid    = {41446157},
  url     = {https://doi.org/10.64898/2025.12.17.694758}
}

@article{bosco2024-38260601,
  author  = {Bosco, Dale B and Kremen, Vaclav and Haruwaka, Koichiro and Zhao, Shunyi and Wang, Lingxiao and Ebner, Blake A and Zheng, Jiaying and Dheer, Aastha and others},
  title   = {{Impaired microglial phagocytosis promotes seizure development}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2024},
  doi     = {10.1101/2023.12.31.573794},
  pmid    = {38260601},
  url     = {https://doi.org/10.1101/2023.12.31.573794}
}

@article{philippe2025-41394664,
  author  = {Philippe, Tristan J and Avey, Denis R and Kearns, Nicola A and Vyas, Himanshu and De Tissera, Sashini and Xu, Jishu and Ng, Bernard and Saunders, Devin M and others},
  title   = {{A Multi-omic Atlas of Human Choroid Plexus in Alzheimer's Disease}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.1101/2025.11.23.690014},
  pmid    = {41394664},
  url     = {https://doi.org/10.1101/2025.11.23.690014}
}

@article{chou2023-36865139,
  author  = {Chou, Vicky and Fancher, Seeley B and Pearse, Richard V and Lee, Hyo and Lam, Matti and Seyfried, Nicholas T and Bennett, David A and De Jager, Phillip L and others},
  title   = {{INPP5D/SHIP1 regulates inflammasome activation in human microglia}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2023},
  doi     = {10.1101/2023.02.25.530025},
  pmid    = {36865139},
  url     = {https://doi.org/10.1101/2023.02.25.530025}
}

@article{vanschaik2026-b4bfc569,
  author  = {van Schaik, M. and Lai, K. O. and Shapiro, N. L. and Jäck, A. and Goddard, J. and Crook, H. and Frohn, R. and Jones, P. S. and others},
  title   = {{Plasma immune signatures associate with neurodegeneration in frontotemporal lobar degeneration}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.26364155},
  url     = {https://doi.org/10.64898/2026.09.28.26364155}
}

@article{sharma2026-c554220d,
  author  = {Sharma, A. and Aylar, D. and Lapin, D. and Marambaud, P. and Wang, P.},
  title   = {{Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.18.752724},
  url     = {https://doi.org/10.64898/2026.09.18.752724}
}

@article{liu2026-6e29bce4,
  author  = {Liu, X. and Liu, Z. and Lv, Z. and Lei, Y. and Zhou, Z. and Xu, Z. and Duan, J. and Xing, W. and others},
  title   = {{Mechanistic study of PHLDA1 in cognitive dysfunction of Alzheimer’s disease model mice via FoxO1‑mediated neuroinflammation}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10948741/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10948741/v1}
}

@article{upadhyay2026-fce28563,
  author  = {Upadhyay, S. and Zhang, L. and Kaur, B. and Calvo-Barreiro, L. and Teplova, M. and Gabr, M.},
  title   = {{Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.15.759511},
  url     = {https://doi.org/10.64898/2026.10.15.759511}
}

@article{dekleijn2026-4fee9899,
  author  = {de Kleijn, K. and Weller, S. and Klaassen, R. and Koopmans, F. and Smit, A. and Wijdeven, R.},
  title   = {{The TREM-receptor family interactome in the human brain}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.28.762136},
  url     = {https://doi.org/10.64898/2026.10.28.762136}
}

@article{lee2026-ce9e4ee2,
  author  = {Lee, H. and Peppler, G. B. and Sewell, M. and Münch, A. and Podleśny-Drabiniok, A. and Kim, J. J. and Orrick, J. and Marcora, E. and others},
  title   = {{A rapid, genetically-tractable human iPSC-derived model for studying tissue-resident macrophage biology in Alzheimer’s and other diseases}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.08.757653},
  url     = {https://doi.org/10.64898/2026.10.08.757653}
}

@article{danhash2026-f606cf98,
  author  = {Danhash, E. P. and Verbeck, A. C. and Iyer, A. K. and Karch, C. M.},
  title   = {{Ms4a4a loss preferentially remodels microglia with limited, compartment-specific effects across central and peripheral immune compartments in 5xFAD mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.26.762005},
  url     = {https://doi.org/10.64898/2026.10.26.762005}
}

@article{zott2026-90b7bcf3,
  author  = {Zott, B. and Unger, F. and Wolf, C. and Schlepckow, K. and Ulmer, N. and Rossignol, P. and Pousinha, P. and Chen, L. and others},
  title   = {{Soluble TREM2 suppresses neuronal activity}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11388834/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11388834/v1}
}

@article{tan2026-437238a8,
  author  = {Tan, Q. and Xie, A. and Chen, J. and Wei, S. and Guo, Y. and Liu, G. and Wang, L. and Liu, X. and others},
  title   = {{Electroacupuncture alleviate cognitive impairment via activation of TREM2-positive microglia in APP/PS1 mice}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11138446/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11138446/v1}
}

@article{leon2026-1faaf0d8,
  author  = {Leon, J. and Yoshinaga, S. and Koya, I. and Palafox, G. and Ando, Y. and Kubo, K. and Moody, J. and Takao, M. and others},
  title   = {{DAP12-deficient microglia adopt a TREM2-independent antigen-presenting state with a glial-to-neuronal cascade in Nasu-Hakola disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.07.757387},
  url     = {https://doi.org/10.64898/2026.10.07.757387}
}

@article{lin2026-703e2eb0,
  author  = {Lin, D. and Atkinson, JR. and Wu, W. and Chen, M. and Jayasekara, S. and Segal, B. M. and Ma, A. and Gao, J.},
  title   = {{A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.16.752098},
  url     = {https://doi.org/10.64898/2026.09.16.752098}
}

@article{antonbarros2026-0ceb195a,
  author  = {Antón-Barros, C. and Villarejo-Zori, B. and Carmona-Lorenzo, S. and Barbero-Paredes, J. M. and González-Díaz, D. and Uceda, M. and Fernàndez-Bernal, A. and Portero-Otín, M. and others},
  title   = {{A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.10.750647},
  url     = {https://doi.org/10.64898/2026.09.10.750647}
}

@article{kuhnau2026-4fd9d702,
  author  = {Kuhnau, L. and Jimenez, G. A. and Hack, W. and Varada, S. and Gladen-Kolarsky, N. and Kim, S. and Klein, F. and Banerji, T. and others},
  title   = {{The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.31.741838},
  url     = {https://doi.org/10.64898/2026.07.31.741838}
}

@article{rodriguez2026-ef1dd141,
  author  = {Rodríguez, E. M. and Zaragoza-Ballester, P. and Alcolea, D. and Esteller-Gauxax, D. and Nuscher, B. and Chacón, S. and Á, Fernández-León and Í, Rodríguez-Baz and others},
  title   = {{APOEε4 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodies}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10429506/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10429506/v1}
}

@article{krunic2026-ec5a997c,
  author  = {Krunic, A. and Umesh Ganesh, N. and Coskun, U. and Brennan, W. and Patel, C. and Joshi, O. and Lee, J. and Gu, T. S. and others},
  title   = {{MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer’s Disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.20.738977},
  url     = {https://doi.org/10.64898/2026.07.20.738977}
}

@article{srikanth2026-e12d5e2b,
  author  = {Srikanth, M. and Jiang, S. and Wellman, S. M. and Sarkar, S. and Lorman, D. E. and Lantin, T. and Runyan, A. M. and Kumar, M. and others},
  title   = {{Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.14.738427},
  url     = {https://doi.org/10.64898/2026.07.14.738427}
}

@article{chen2026-b03c3c29,
  author  = {Chen, X. and Munoz-Mayorga, D. and Lyu, X. and Jati, S. and Zhang, J. and Rossitto, L. and Tao, Y. and Zhao, S. and others},
  title   = {{A non-canonical androgen signaling pathway drives microglial activation and tau pathology in females}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10286730/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10286730/v1}
}

@article{balistreri2026-20d3f448,
  author  = {Balistreri, A. and Gomulinski, M. and Chapman, M. R. and Kelly, J. W.},
  title   = {{The Microglial Protein sTREM2 Inhibits the Bacterial Functional Amyloid CsgA and Suppresses Amyloid-Dependent Biofilm Formation}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.03.736422},
  url     = {https://doi.org/10.64898/2026.07.03.736422}
}

@article{algamal2026-005bc584,
  author  = {Algamal, M. and Yokomizo, S. and Ndambakuwa, W. and Abdallah, S. and Sanchez-Mico, M. V. and Gillani, R. and da Silva, P. and Rajput, A. and others},
  title   = {{Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.07.749938},
  url     = {https://doi.org/10.64898/2026.09.07.749938}
}

@article{aggarwal2026-715fc47c,
  author  = {Aggarwal, G. and Banerjee, S. and Bhadra, A. K. and Hwang, J. J. and Malabana, D. A. O. and Nagarajan, N. and Smith, D. M. and Kollarapu, J. and others},
  title   = {{Progranulin deficiency promotes neuroinflammation through cathepsin B-mediated activation of the NLRP3 inflammasome}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.11.758389},
  url     = {https://doi.org/10.64898/2026.10.11.758389}
}

@article{rausch2026-a2d21860,
  author  = {Rausch, D. M. and Ludwig, M. Q. and Bentsen, M. A. and Hansen, S. N. and Secher, A. and Holst, D. and Moreno, J. and Das, V. and others},
  title   = {{Semaglutide Attenuates Neuroinflammation in Mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.01.10.698763},
  url     = {https://doi.org/10.64898/2026.01.10.698763}
}

@article{badachhape2026-78820a75,
  author  = {Badachhape, A. A. and Bhandari, P. and Khan, R. and Bhavane, R. and Menon, R. and Parekh, P. and Admane, P. and Ngan, E. and others},
  title   = {{Molecular MRI of Neuroinflammation in Alzheimer's Disease using a Folate-targeted Nanoprobe}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.27.761963},
  url     = {https://doi.org/10.64898/2026.10.27.761963}
}

@article{devlin2026-50f6f595,
  author  = {Devlin, M. and Rodstrom, K. and Benkerdagh, C. and Ber, S. and Ramsden, N. and Rowlett, M. and Cordeiro, S. and Hayre, M. and others},
  title   = {{A Binding Site for CVN293 Reveals a Mechanism for Allosteric Control of THIK-1 K2P Channel Gating}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.27.761881},
  url     = {https://doi.org/10.64898/2026.10.27.761881}
}

@article{quang2026-09848cb6,
  author  = {Quang, D. and Summers, R. and Dooling, B. R. and Esquer, H. and Zhou, Q. and LaBarbera, D. V. and Vergara, M. N. and Chial, H. J. and others},
  title   = {{High-content imaging of live microglia-containing Alzheimer’s disease brain organoids}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.26.761970},
  url     = {https://doi.org/10.64898/2026.10.26.761970}
}

@article{ghosh2026-549141c1,
  author  = {Ghosh, B. and Wang, S. and Qi, C. and Ghosh, A. and Comerota, M. and Rajpurohit, C. S. and Zeldin, D. C. and Zheng, H.},
  title   = {{Astrocytic sEH–EET signaling regulates microglial lysosomal function and suppresses the STING–Type I interferon pathway in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.16.759679},
  url     = {https://doi.org/10.64898/2026.10.16.759679}
}

@article{juardar2026-b4b52380,
  author  = {Juardar, P. P. and George, K. and Roy, R. K.},
  title   = {{Protective or Pathogenic? Microglial Responses at the Intersection of Amyloid-β, Tau, and Neuroinflammation in Alzheimer’s Disease}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202610.1771.v1},
  url     = {https://doi.org/10.20944/preprints202610.1771.v1}
}

@article{thakur2026-ca6358d7,
  author  = {Thakur, K. and Péladeau, C. and Hewitt, M. and Baumann, K. and Cai, D. and Woulfe, J. M. and Tomlinson, J. J. and Schlossmacher, M. G. and others},
  title   = {{ASC specks and α-synuclein amplify microglial NLRP3 inflammasome activation and co-localize with Lewy body pathology}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.02.756339},
  url     = {https://doi.org/10.64898/2026.10.02.756339}
}

@article{kim2026-376fe0f8,
  author  = {Kim, N. and Jeong, D. S. and Lee, Y. and Oh, C.},
  title   = {{Human multiscale transcriptomics identifies the NLRP3 inflammasome as a convergent druggable target in Alzheimer’s disease: validation with dimethyl itaconate in 5xFAD mice}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11103693/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11103693/v1}
}

@article{huang2026-f63e9b8e,
  author  = {Huang, E. and Lu, R. and Choi, J. and Jahan, N. and Imhof, I. and Collo, S. and Eguiguren, S. and Zhang, J. and others},
  title   = {{TLR7-mediated autoimmunity targets Robo3 to drive astrogliosis in frontotemporal dementia}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11236688/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11236688/v1}
}

@article{mercado2026-398d9a8d,
  author  = {Mercado, G. and Stetzik, L. and Schulz, E. and Meyerdirk, L. and Lindquist, A. and Cohen, L. and Escobar Galvis, M. L. and Steiner, J. A. and others},
  title   = {{Neuroinflammation is an early pathological process in a mouse model of prodromal Parkinsons disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.29.762888},
  url     = {https://doi.org/10.64898/2026.10.29.762888}
}