% alzhub.org library filter % Source: https://alzhub.org/research?category=inflammation&atag=transgenic % 195 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{scott2018-29272357, author = {Scott, G. and Zetterberg, H. and Jolly, A. and Cole, J. H. and De Simoni, S. and Jenkins, P. O. and Feeney, C. and Owen, D. R. and others}, title = {{Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration}}, journal = {Brain : a journal of neurology}, year = {2018}, doi = {10.1093/brain/awx339}, pmid = {29272357}, url = {https://doi.org/10.1093/brain/awx339} } @article{liddelow2017-28099414, author = {Liddelow, Shane A. and Guttenplan, Kevin A. and Clarke, Laura E. and Bennett, F. Chris and Bohlen, Christopher J. and Schirmer, Lucas and Bennett, Mariko L. and Münch, Alexandra E. and others}, title = {{Neurotoxic reactive astrocytes are induced by activated microglia}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature21029}, pmid = {28099414}, url = {https://doi.org/10.1038/nature21029} } @article{noori2021-33347974, author = {Noori, A. and Mezlini, A. M. and Hyman, B. T. and Serrano-Pozo, A. and Das, S.}, title = {{Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration}}, journal = {Neurobiology of disease}, year = {2021}, doi = {10.1016/j.nbd.2020.105225}, pmid = {33347974}, url = {https://doi.org/10.1016/j.nbd.2020.105225} } @article{damesquita2021-33911285, author = {Da Mesquita, S. and Papadopoulos, Z. and Dykstra, T. and Brase, L. and Farias, F. G. and Wall, M. and Jiang, H. and Kodira, C. D. and others}, title = {{Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy}}, journal = {Nature}, year = {2021}, doi = {10.1038/s41586-021-03489-0}, pmid = {33911285}, url = {https://doi.org/10.1038/s41586-021-03489-0} } @article{udeochu2023-37095396, author = {Udeochu, J. C. and Amin, S. and Huang, Y. and Fan, L. and Torres, E. R. S. and Carling, G. K. and Liu, B. and McGurran, H. and others}, title = {{Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience}}, journal = {Nature neuroscience}, year = {2023}, doi = {10.1038/s41593-023-01315-6}, pmid = {37095396}, url = {https://doi.org/10.1038/s41593-023-01315-6} } @article{kamaruzzaman2023-36959856, author = {Kamaruzzaman, M. A. and Romli, M. H. and Abas, R. and Vidyadaran, S. and Hidayat Baharuldin, M. T. and Nasaruddin, M. L. and Thirupathirao, V. and Sura, S. and others}, title = {{Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer's disease: A systematic review and meta-analysis of animal studies}}, journal = {Frontiers in pharmacology}, year = {2023}, doi = {10.3389/fphar.2023.1053680}, pmid = {36959856}, url = {https://doi.org/10.3389/fphar.2023.1053680} } @article{paolicelli2011-21778362, author = {Paolicelli, Rosa Chiara and Bolasco, Giulia and Pagani, Francesca and Maggi, Laura and Scianni, Maria and Panzanelli, Patrizia and Giustetto, Maurizio and Ferreira, Tiago and Guiducci, Eva and Dumas, Laura and Ragozzino, Davide and Gross, Cornelius Thilo}, title = {{Synaptic Pruning by Microglia Is Necessary for Normal Brain Development}}, journal = {Science}, year = {2011}, doi = {10.1126/science.1202529}, pmid = {21778362}, url = {https://doi.org/10.1126/science.1202529} } @article{stevens2007-18083105, author = {Stevens, Beth A. and Allen, Nicola J. and Vazquez, Luis E and Howell, Gareth R. and Christopherson, Karen S. and Nouri, Navid and Micheva, Kristina D. and Mehalow, Adrienne K. and Huberman, Andrew D. and Stafford, Benjamin K. and Sher, Alexander and Litke, Alan M and Lambris, John D. and Smith, Stephen J and John, Simon W. M. and Barres, Ben A.}, title = {{The Classical Complement Cascade Mediates CNS Synapse Elimination}}, journal = {Cell}, year = {2007}, doi = {10.1016/j.cell.2007.10.036}, pmid = {18083105}, url = {https://doi.org/10.1016/j.cell.2007.10.036} } @article{laurent2017-27818384, author = {Laurent, C. and Dorothée, G. and Hunot, S. and Martin, E. and Monnet, Y. and Duchamp, M. and Dong, Y. and Légeron, F. P. and others}, title = {{Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy}}, journal = {Brain : a journal of neurology}, year = {2017}, doi = {10.1093/brain/aww270}, pmid = {27818384}, url = {https://doi.org/10.1093/brain/aww270} } @article{wong2017-28170377, author = {Wong, Y. C. and Krainc, D.}, title = {{α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies}}, journal = {Nature medicine}, year = {2017}, doi = {10.1038/nm.4269}, pmid = {28170377}, url = {https://doi.org/10.1038/nm.4269} } @article{dicaro2026-41943055, author = {Di Caro, V. and Cho, E. and Thiel, J. and Lizama, B. N. and Koel-Simmelink, M. J. A. and Pandey, K. and Duong, D. and Seyfried, N. T. and others}, title = {{Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2026}, doi = {10.1186/s13195-026-02025-4}, pmid = {41943055}, url = {https://doi.org/10.1186/s13195-026-02025-4} } @article{he1997-9024664, author = {He, J. and Chen, Y. and Farzan, M. and Choe, H. and Ohagen, A. and Gartner, S. and Busciglio, J. and Yang, X. and others}, title = {{CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia}}, journal = {Nature}, year = {1997}, doi = {10.1038/385645a0}, pmid = {9024664}, url = {https://doi.org/10.1038/385645a0} } @article{kuchibhotla2009-19251629, author = {Kuchibhotla, K. V. and Lattarulo, C. R. and Hyman, B. T. and Bacskai, B. J.}, title = {{Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice}}, journal = {Science (New York, N.Y.)}, year = {2009}, doi = {10.1126/science.1169096}, pmid = {19251629}, url = {https://doi.org/10.1126/science.1169096} } @article{patani2023-37308616, author = {Patani, R. and Hardingham, G. E. and Liddelow, S. A.}, title = {{Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration}}, journal = {Nature reviews. Neurology}, year = {2023}, doi = {10.1038/s41582-023-00822-1}, pmid = {37308616}, url = {https://doi.org/10.1038/s41582-023-00822-1} } @article{chen2026-41785364, author = {Chen, Yun and Liu, Yizhou A. and Nguyen, Khai M. and Wu, Junjie and Song, Sihui and Lin, Kent and Rodrigues, Patrick Fernandes and Du, Siling and others}, title = {{Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy}}, journal = {Science}, year = {2026}, doi = {10.1126/science.ads3972}, pmid = {41785364}, url = {https://doi.org/10.1126/science.ads3972} } @article{tejera2019-31359456, author = {Tejera, D. and Mercan, D. and Sanchez-Caro, J. M. and Hanan, M. and Greenberg, D. and Soreq, H. and Latz, E. and Golenbock, D. and others}, title = {{Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome}}, journal = {The EMBO journal}, year = {2019}, doi = {10.15252/embj.2018101064}, pmid = {31359456}, url = {https://doi.org/10.15252/embj.2018101064} } @article{condello2015-25630253, author = {Condello, Carlo and Yuan, Peng and Schain, Aaron J. and Grutzendler, Jaime}, title = {{Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques}}, journal = {Nature Communications}, year = {2015}, doi = {10.1038/ncomms7176}, pmid = {25630253}, url = {https://doi.org/10.1038/ncomms7176} } @article{logan2021-34450028, author = {Logan, T. and Simon, M. J. and Rana, A. and Cherf, G. M. and Srivastava, A. and Davis, S. S. and Low, R. L. Y. and Chiu, C. L. and others}, title = {{Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic}}, journal = {Cell}, year = {2021}, doi = {10.1016/j.cell.2021.08.002}, pmid = {34450028}, url = {https://doi.org/10.1016/j.cell.2021.08.002} } @article{ross2013-23968157, author = {Ross, J. and Sharma, S. and Winston, J. and Nunez, M. and Bottini, G. and Franceschi, M. and Scarpini, E. and Frigerio, E. and others}, title = {{CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study}}, journal = {Current Alzheimer research}, year = {2013}, doi = {10.2174/13892037113149990144}, pmid = {23968157}, url = {https://doi.org/10.2174/13892037113149990144} } @article{yuan2019-30467385, author = {Yuan, J. and Amin, P. and Ofengeim, D.}, title = {{Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases}}, journal = {Nature reviews. Neuroscience}, year = {2019}, doi = {10.1038/s41583-018-0093-1}, pmid = {30467385}, url = {https://doi.org/10.1038/s41583-018-0093-1} } @article{flores2018-30254377, author = {Flores, J. and Noël, A. and Foveau, B. and Lynham, J. and Lecrux, C. and LeBlanc, A. C.}, title = {{Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model}}, journal = {Nature communications}, year = {2018}, doi = {10.1038/s41467-018-06449-x}, pmid = {30254377}, url = {https://doi.org/10.1038/s41467-018-06449-x} } @article{jalouli2025-39981183, author = {Jalouli, Maroua and Rahman, Md. Ataur and Biswas, Partha and Rahman, Hasanur and Harrath, Abdel Halim and Lee, In-Seon and Kang, Sojin and Choi, Jinwon and others}, title = {{Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review}}, journal = {Frontiers in Pharmacology}, year = {2025}, doi = {10.3389/fphar.2025.1492517}, pmid = {39981183}, url = {https://doi.org/10.3389/fphar.2025.1492517} } @article{chen2005-16183991, author = {Chen, J. and Zhou, Y. and Mueller-Steiner, S. and Chen, L. F. and Kwon, H. and Yi, S. and Mucke, L. and Gan, L.}, title = {{SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m509329200}, pmid = {16183991}, url = {https://doi.org/10.1074/jbc.m509329200} } @article{li2003-12629164, author = {Li, Y. and Liu, L. and Barger, S. W. and Griffin, W. S.}, title = {{Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2003}, doi = {10.1523/jneurosci.23-05-01605.2003}, pmid = {12629164}, url = {https://doi.org/10.1523/jneurosci.23-05-01605.2003} } @article{sun2019-31383855, author = {Sun, J. and Xu, J. and Ling, Y. and Wang, F. and Gong, T. and Yang, C. and Ye, S. and Ye, K. and others}, title = {{Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice}}, journal = {Translational psychiatry}, year = {2019}, doi = {10.1038/s41398-019-0525-3}, pmid = {31383855}, url = {https://doi.org/10.1038/s41398-019-0525-3} } @article{zhao2021-34530866, author = {Zhao, Y. and Zhang, J. and Zheng, Y. and Zhang, Y. and Zhang, X. J. and Wang, H. and Du, Y. and Guan, J. and others}, title = {{NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway}}, journal = {Journal of neuroinflammation}, year = {2021}, doi = {10.1186/s12974-021-02250-8}, pmid = {34530866}, url = {https://doi.org/10.1186/s12974-021-02250-8} } @article{han2020-32194838, author = {Han, B. and Jiang, W. and Liu, H. and Wang, J. and Zheng, K. and Cui, P. and Feng, Y. and Dang, C. and others}, title = {{Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion}}, journal = {Theranostics}, year = {2020}, doi = {10.7150/thno.37119}, pmid = {32194838}, url = {https://doi.org/10.7150/thno.37119} } @article{kaul1999-10393974, author = {Kaul, M. and Lipton, S. A.}, title = {{Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1999}, doi = {10.1073/pnas.96.14.8212}, pmid = {10393974}, url = {https://doi.org/10.1073/pnas.96.14.8212} } @article{neher2013-24101459, author = {Neher, J. J. and Emmrich, J. V. and Fricker, M. and Mander, P. K. and Théry, C. and Brown, G. C.}, title = {{Phagocytosis executes delayed neuronal death after focal brain ischemia}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2013}, doi = {10.1073/pnas.1308679110}, pmid = {24101459}, url = {https://doi.org/10.1073/pnas.1308679110} } @article{martens2012-23041626, author = {Martens, L. H. and Zhang, J. and Barmada, S. J. and Zhou, P. and Kamiya, S. and Sun, B. and Min, S. W. and Gan, L. and others}, title = {{Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury}}, journal = {The Journal of clinical investigation}, year = {2012}, doi = {10.1172/jci63113}, pmid = {23041626}, url = {https://doi.org/10.1172/jci63113} } @article{park2021-33902708, author = {Park, J. S. and Kam, T. I. and Lee, S. and Park, H. and Oh, Y. and Kwon, S. H. and Song, J. J. and Kim, D. and others}, title = {{Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease}}, journal = {Acta neuropathologica communications}, year = {2021}, doi = {10.1186/s40478-021-01180-z}, pmid = {33902708}, url = {https://doi.org/10.1186/s40478-021-01180-z} } @article{seo2017-28912154, author = {Seo, J. and Kritskiy, O. and Watson, L. A. and Barker, S. J. and Dey, D. and Raja, W. K. and Lin, Y. T. and Ko, T. and others}, title = {{Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2017}, doi = {10.1523/jneurosci.0621-17.2017}, pmid = {28912154}, url = {https://doi.org/10.1523/jneurosci.0621-17.2017} } @article{takeuchi2006-16720574, author = {Takeuchi, H. and Jin, S. and Wang, J. and Zhang, G. and Kawanokuchi, J. and Kuno, R. and Sonobe, Y. and Mizuno, T. and others}, title = {{Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner}}, journal = {The Journal of biological chemistry}, year = {2006}, doi = {10.1074/jbc.m600504200}, pmid = {16720574}, url = {https://doi.org/10.1074/jbc.m600504200} } @article{shaftel2007-17549256, author = {Shaftel, S. S. and Kyrkanides, S. and Olschowka, J. A. and Miller, J. N. and Johnson, R. E. and O'Banion, M. K.}, title = {{Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology}}, journal = {The Journal of clinical investigation}, year = {2007}, doi = {10.1172/jci31450}, pmid = {17549256}, url = {https://doi.org/10.1172/jci31450} } @article{liu2002-12076984, author = {Liu, B. and Gao, H. M. and Wang, J. Y. and Jeohn, G. H. and Cooper, C. L. and Hong, J. S.}, title = {{Role of nitric oxide in inflammation-mediated neurodegeneration}}, journal = {Annals of the New York Academy of Sciences}, year = {2002}, doi = {10.1111/j.1749-6632.2002.tb04077.x}, pmid = {12076984}, url = {https://doi.org/10.1111/j.1749-6632.2002.tb04077.x} } @article{bagasra1996-8780811, author = {Bagasra, O. and Lavi, E. and Bobroski, L. and Khalili, K. and Pestaner, J. P. and Tawadros, R. and Pomerantz, R. J.}, title = {{Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry}}, journal = {AIDS (London, England)}, year = {1996}, doi = {10.1097/00002030-199606000-00002}, pmid = {8780811}, url = {https://doi.org/10.1097/00002030-199606000-00002} } @article{bae2012-23015436, author = {Bae, E. J. and Lee, H. J. and Rockenstein, E. and Ho, D. H. and Park, E. B. and Yang, N. Y. and Desplats, P. and Masliah, E. and others}, title = {{Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2012}, doi = {10.1523/jneurosci.1292-12.2012}, pmid = {23015436}, url = {https://doi.org/10.1523/jneurosci.1292-12.2012} } @article{lee2003-12655043, author = {Lee, J. and Ryu, H. and Ferrante, R. J. and Morris, S. M. and Ratan, R. R.}, title = {{Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2003}, doi = {10.1073/pnas.0735876100}, pmid = {12655043}, url = {https://doi.org/10.1073/pnas.0735876100} } @article{gaikwad2021-34289368, author = {Gaikwad, S. and Puangmalai, N. and Bittar, A. and Montalbano, M. and Garcia, S. and McAllen, S. and Bhatt, N. and Sonawane, M. and others}, title = {{Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia}}, journal = {Cell reports}, year = {2021}, doi = {10.1016/j.celrep.2021.109419}, pmid = {34289368}, url = {https://doi.org/10.1016/j.celrep.2021.109419} } @article{wang2017-28188218, author = {Wang, M. and Ding, F. and Deng, S. and Guo, X. and Wang, W. and Iliff, J. J. and Nedergaard, M.}, title = {{Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2017}, doi = {10.1523/jneurosci.2112-16.2017}, pmid = {28188218}, url = {https://doi.org/10.1523/jneurosci.2112-16.2017} } @article{saha2021-35126058, author = {Saha, S. and Buttari, B. and Profumo, E. and Tucci, P. and Saso, L.}, title = {{A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases}}, journal = {Frontiers in cellular neuroscience}, year = {2021}, doi = {10.3389/fncel.2021.787258}, pmid = {35126058}, url = {https://doi.org/10.3389/fncel.2021.787258} } @article{he2017-28579942, author = {He, X. F. and Liu, D. X. and Zhang, Q. and Liang, F. Y. and Dai, G. Y. and Zeng, J. S. and Pei, Z. and Xu, G. Q. and others}, title = {{Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice}}, journal = {Frontiers in molecular neuroscience}, year = {2017}, doi = {10.3389/fnmol.2017.00144}, pmid = {28579942}, url = {https://doi.org/10.3389/fnmol.2017.00144} } @article{gu2010-20409326, author = {Gu, X. L. and Long, C. X. and Sun, L. and Xie, C. and Lin, X. and Cai, H.}, title = {{Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice}}, journal = {Molecular brain}, year = {2010}, doi = {10.1186/1756-6606-3-12}, pmid = {20409326}, url = {https://doi.org/10.1186/1756-6606-3-12} } @article{kirkley2017-28476157, author = {Kirkley, K. S. and Popichak, K. A. and Afzali, M. F. and Legare, M. E. and Tjalkens, R. B.}, title = {{Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity}}, journal = {Journal of neuroinflammation}, year = {2017}, doi = {10.1186/s12974-017-0871-0}, pmid = {28476157}, url = {https://doi.org/10.1186/s12974-017-0871-0} } @article{jantzen2002-11896164, author = {Jantzen, P. T. and Connor, K. E. and DiCarlo, G. and Wenk, G. L. and Wallace, J. L. and Rojiani, A. M. and Coppola, D. and Morgan, D. and others}, title = {{Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2002}, doi = {10.1523/jneurosci.22-06-02246.2002}, pmid = {11896164}, url = {https://doi.org/10.1523/jneurosci.22-06-02246.2002} } @article{kaushal2015-25744023, author = {Kaushal, V. and Dye, R. and Pakavathkumar, P. and Foveau, B. and Flores, J. and Hyman, B. and Ghetti, B. and Koller, B. H. and others}, title = {{Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation}}, journal = {Cell death and differentiation}, year = {2015}, doi = {10.1038/cdd.2015.16}, pmid = {25744023}, url = {https://doi.org/10.1038/cdd.2015.16} } @article{neniskyte2011-21903584, author = {Neniskyte, U. and Neher, J. J. and Brown, G. C.}, title = {{Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia}}, journal = {The Journal of biological chemistry}, year = {2011}, doi = {10.1074/jbc.m111.267583}, pmid = {21903584}, url = {https://doi.org/10.1074/jbc.m111.267583} } @article{xiao2025-40581647, author = {Xiao, Weiping and Yang, Yibing and Lu, Bai and Yang, Peixuan and Li, Runze and Yang, Daizhi and Li, Fanying and Quan, Lingzhi and others}, title = {{Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis}}, journal = {Journal of Neuroinflammation}, year = {2025}, doi = {10.1186/s12974-025-03493-5}, pmid = {40581647}, url = {https://doi.org/10.1186/s12974-025-03493-5} } @article{su2025-40595567, author = {Su, Yixun and Li, Hui and Zhang, Wenjie and Tao, Shi and Wang, Qi and Zhang, Xuan and Zhou, Mi and Huang, Xiaomin and others}, title = {{Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis}}, journal = {Nature Communications}, year = {2025}, doi = {10.1038/s41467-025-60746-w}, pmid = {40595567}, url = {https://doi.org/10.1038/s41467-025-60746-w} } @article{yuyama2012-22303002, author = {Yuyama, K. and Sun, H. and Mitsutake, S. and Igarashi, Y.}, title = {{Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia}}, journal = {The Journal of biological chemistry}, year = {2012}, doi = {10.1074/jbc.m111.324616}, pmid = {22303002}, url = {https://doi.org/10.1074/jbc.m111.324616} } @article{eugenin2006-16436595, author = {Eugenin, E. A. and Osiecki, K. and Lopez, L. and Goldstein, H. and Calderon, T. M. and Berman, J. W.}, title = {{CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2006}, doi = {10.1523/jneurosci.3863-05.2006}, pmid = {16436595}, url = {https://doi.org/10.1523/jneurosci.3863-05.2006} } @article{deane2004-15459432, author = {Deane, R. and Wu, Z. and Zlokovic, B. V.}, title = {{RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier}}, journal = {Stroke}, year = {2004}, doi = {10.1161/01.str.0000143452.85382.d1}, pmid = {15459432}, url = {https://doi.org/10.1161/01.str.0000143452.85382.d1} } @article{spagnuolo2018-28923363, author = {Spagnuolo, C. and Moccia, S. and Russo, G. L.}, title = {{Anti-inflammatory effects of flavonoids in neurodegenerative disorders}}, journal = {European journal of medicinal chemistry}, year = {2018}, doi = {10.1016/j.ejmech.2017.09.001}, pmid = {28923363}, url = {https://doi.org/10.1016/j.ejmech.2017.09.001} } @article{fine1996-8663435, author = {Fine, S. M. and Angel, R. A. and Perry, S. W. and Epstein, L. G. and Rothstein, J. D. and Dewhurst, S. and Gelbard, H. A.}, title = {{Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia}}, journal = {The Journal of biological chemistry}, year = {1996}, doi = {10.1074/jbc.271.26.15303}, pmid = {8663435}, url = {https://doi.org/10.1074/jbc.271.26.15303} } @article{mcdonald1997-9065490, author = {McDonald, D. R. and Brunden, K. R. and Landreth, G. E.}, title = {{Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {1997}, doi = {10.1523/jneurosci.17-07-02284.1997}, pmid = {9065490}, url = {https://doi.org/10.1523/jneurosci.17-07-02284.1997} } @article{michaud2013-23322736, author = {Michaud, J. P. and Hallé, M. and Lampron, A. and Thériault, P. and Préfontaine, P. and Filali, M. and Tribout-Jover, P. and Lanteigne, A. M. and others}, title = {{Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2013}, doi = {10.1073/pnas.1215165110}, pmid = {23322736}, url = {https://doi.org/10.1073/pnas.1215165110} } @article{michailidou2015-25727254, author = {Michailidou, I. and Willems, J. G. and Kooi, E. J. and van Eden, C. and Gold, S. M. and Geurts, J. J. and Baas, F. and Huitinga, I. and others}, title = {{Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus}}, journal = {Annals of neurology}, year = {2015}, doi = {10.1002/ana.24398}, pmid = {25727254}, url = {https://doi.org/10.1002/ana.24398} } @article{roumier2004-15601948, author = {Roumier, A. and Béchade, C. and Poncer, J. C. and Smalla, K. H. and Tomasello, E. and Vivier, E. and Gundelfinger, E. D. and Triller, A. and others}, title = {{Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2004}, doi = {10.1523/jneurosci.2251-04.2004}, pmid = {15601948}, url = {https://doi.org/10.1523/jneurosci.2251-04.2004} } @article{lall2017-28737506, author = {Lall, D. and Baloh, R. H.}, title = {{Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia}}, journal = {The Journal of clinical investigation}, year = {2017}, doi = {10.1172/jci90607}, pmid = {28737506}, url = {https://doi.org/10.1172/jci90607} } @article{lenoel2025-40858618, author = {Lenoël, Isadora and Ribon, Matthieu and Lorenc, Félicie and Diebold, Aurélien and Philibert, Clémentine Eva and Robaldo, David and Badsi, Manel and Perronnet, Julianne and others}, title = {{ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice}}, journal = {Nature Communications}, year = {2025}, doi = {10.1038/s41467-025-63211-w}, pmid = {40858618}, url = {https://doi.org/10.1038/s41467-025-63211-w} } @article{guillemin2001-11520905, author = {Guillemin, G. J. and Kerr, S. J. and Smythe, G. A. and Smith, D. G. and Kapoor, V. and Armati, P. J. and Croitoru, J. and Brew, B. J.}, title = {{Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection}}, journal = {Journal of neurochemistry}, year = {2001}, doi = {10.1046/j.1471-4159.2001.00498.x}, pmid = {11520905}, url = {https://doi.org/10.1046/j.1471-4159.2001.00498.x} } @article{cartier2005-15708626, author = {Cartier, L. and Hartley, O. and Dubois-Dauphin, M. and Krause, K. H.}, title = {{Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases}}, journal = {Brain research. Brain research reviews}, year = {2005}, doi = {10.1016/j.brainresrev.2004.07.021}, pmid = {15708626}, url = {https://doi.org/10.1016/j.brainresrev.2004.07.021} } @article{cho2014-25126727, author = {Cho, M. H. and Cho, K. and Kang, H. J. and Jeon, E. Y. and Kim, H. S. and Kwon, H. J. and Kim, H. M. and Kim, D. H. and others}, title = {{Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome}}, journal = {Autophagy}, year = {2014}, doi = {10.4161/auto.29647}, pmid = {25126727}, url = {https://doi.org/10.4161/auto.29647} } @article{cui2018-28970251, author = {Cui, G. H. and Wu, J. and Mou, F. F. and Xie, W. H. and Wang, F. B. and Wang, Q. L. and Fang, J. and Xu, Y. W. and others}, title = {{Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice}}, journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year = {2018}, doi = {10.1096/fj.201700600r}, pmid = {28970251}, url = {https://doi.org/10.1096/fj.201700600r} } @article{catorce2016-26639457, author = {Catorce, M. N. and Gevorkian, G.}, title = {{LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals}}, journal = {Current neuropharmacology}, year = {2016}, doi = {10.2174/1570159x14666151204122017}, pmid = {26639457}, url = {https://doi.org/10.2174/1570159x14666151204122017} } @article{egea2015-26232730, author = {Egea, J. and Buendia, I. and Parada, E. and Navarro, E. and León, R. and Lopez, M. G.}, title = {{Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection}}, journal = {Biochemical pharmacology}, year = {2015}, doi = {10.1016/j.bcp.2015.07.032}, pmid = {26232730}, url = {https://doi.org/10.1016/j.bcp.2015.07.032} } @article{sanz2009-19299738, author = {Sanz, J. M. and Chiozzi, P. and Ferrari, D. and Colaianna, M. and Idzko, M. and Falzoni, S. and Fellin, R. and Trabace, L. and others}, title = {{Activation of microglia by amyloid beta requires P2X7 receptor expression}}, journal = {Journal of immunology (Baltimore, Md. : 1950)}, year = {2009}, doi = {10.4049/jimmunol.0803612}, pmid = {19299738}, url = {https://doi.org/10.4049/jimmunol.0803612} } @article{persidsky1999-10550317, author = {Persidsky, Y. and Ghorpade, A. and Rasmussen, J. and Limoges, J. and Liu, X. J. and Stins, M. and Fiala, M. and Way, D. and others}, title = {{Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis}}, journal = {The American journal of pathology}, year = {1999}, doi = {10.1016/s0002-9440(10)65476-4}, pmid = {10550317}, url = {https://doi.org/10.1016/s0002-9440(10)65476-4} } @article{pabon2011-21266082, author = {Pabon, M. M. and Bachstetter, A. D. and Hudson, C. E. and Gemma, C. and Bickford, P. C.}, title = {{CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease}}, journal = {Journal of neuroinflammation}, year = {2011}, doi = {10.1186/1742-2094-8-9}, pmid = {21266082}, url = {https://doi.org/10.1186/1742-2094-8-9} } @article{weiss1999-10453044, author = {Weiss, J. M. and Nath, A. and Major, E. O. and Berman, J. W.}, title = {{HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes}}, journal = {Journal of immunology (Baltimore, Md. : 1950)}, year = {1999}, doi = {10.4049/jimmunol.163.5.2953}, pmid = {10453044}, url = {https://doi.org/10.4049/jimmunol.163.5.2953} } @article{rhinn2022-35039149, author = {Rhinn, H. and Tatton, N. and McCaughey, S. and Kurnellas, M. and Rosenthal, A.}, title = {{Progranulin as a therapeutic target in neurodegenerative diseases}}, journal = {Trends in pharmacological sciences}, year = {2022}, doi = {10.1016/j.tips.2021.11.015}, pmid = {35039149}, url = {https://doi.org/10.1016/j.tips.2021.11.015} } @article{mori2010-19705461, author = {Mori, T. and Koyama, N. and Arendash, G. W. and Horikoshi-Sakuraba, Y. and Tan, J. and Town, T.}, title = {{Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease}}, journal = {Glia}, year = {2010}, doi = {10.1002/glia.20924}, pmid = {19705461}, url = {https://doi.org/10.1002/glia.20924} } @article{barnett2025-41188644, author = {BARNETT, DANIEL H. and Zimmer, Till S. and Booraem, Caroline and Palaguachi, Fernando and Meadows, Samantha M. and Xiao, Haopeng and Wong, Man Ying and Luo, Wenjie and others}, title = {{Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology}}, journal = {Nature Metabolism}, year = {2025}, doi = {10.1038/s42255-025-01390-y}, pmid = {41188644}, url = {https://doi.org/10.1038/s42255-025-01390-y} } @article{bosworth2025-40048429, author = {Bosworth, Alexandra P and Contreras, Minerva and Sancho, Laura and Salas, Isabel H. and Paumier, Adrien and Novak, Sammy Weiser and Manor, Uri and Allen, Nicola J.}, title = {{Astrocyte glypican 5 regulates synapse maturation and stabilization}}, journal = {Cell Reports}, year = {2025}, doi = {10.1016/j.celrep.2025.115374}, pmid = {40048429}, url = {https://doi.org/10.1016/j.celrep.2025.115374} } @article{brandao2025-39813317, author = {Brandão, Wesley Nogueira and Jain, Nimansha and Yin, Zhuoran and Kleemann, Kilian L. and Carpenter, Madison and Bao, Xin and Serrano, Javier Remolina and Tycksen, Eric and others}, title = {{Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy}}, journal = {Science Translational Medicine}, year = {2025}, doi = {10.1126/scitranslmed.adk3690}, pmid = {39813317}, url = {https://doi.org/10.1126/scitranslmed.adk3690} } @article{thirumangalakudi2008-18410513, author = {Thirumangalakudi, L. and Prakasam, A. and Zhang, R. and Bimonte-Nelson, H. and Sambamurti, K. and Kindy, M. S. and Bhat, N. R.}, title = {{High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice}}, journal = {Journal of neurochemistry}, year = {2008}, doi = {10.1111/j.1471-4159.2008.05415.x}, pmid = {18410513}, url = {https://doi.org/10.1111/j.1471-4159.2008.05415.x} } @article{venneti2006-17156911, author = {Venneti, S. and Lopresti, B. J. and Wiley, C. A.}, title = {{The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging}}, journal = {Progress in neurobiology}, year = {2006}, doi = {10.1016/j.pneurobio.2006.10.002}, pmid = {17156911}, url = {https://doi.org/10.1016/j.pneurobio.2006.10.002} } @article{kang2005-15927426, author = {Kang, D. C. and Su, Z. Z. and Sarkar, D. and Emdad, L. and Volsky, D. J. and Fisher, P. B.}, title = {{Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1}}, journal = {Gene}, year = {2005}, doi = {10.1016/j.gene.2005.04.006}, pmid = {15927426}, url = {https://doi.org/10.1016/j.gene.2005.04.006} } @article{mclarnon2006-17086106, author = {McLarnon, J. G. and Ryu, J. K. and Walker, D. G. and Choi, H. B.}, title = {{Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus}}, journal = {Journal of neuropathology and experimental neurology}, year = {2006}, doi = {10.1097/01.jnen.0000240470.97295.d3}, pmid = {17086106}, url = {https://doi.org/10.1097/01.jnen.0000240470.97295.d3} } @article{gorry2001-11581376, author = {Gorry, P. R. and Bristol, G. and Zack, J. A. and Ritola, K. and Swanstrom, R. and Birch, C. J. and Bell, J. E. and Bannert, N. and others}, title = {{Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity}}, journal = {Journal of virology}, year = {2001}, doi = {10.1128/jvi.75.21.10073-10089.2001}, pmid = {11581376}, url = {https://doi.org/10.1128/jvi.75.21.10073-10089.2001} } @article{lee2010-20228251, author = {Lee, M. and Cho, T. and Jantaratnotai, N. and Wang, Y. T. and McGeer, E. and McGeer, P. L.}, title = {{Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases}}, journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year = {2010}, doi = {10.1096/fj.09-149997}, pmid = {20228251}, url = {https://doi.org/10.1096/fj.09-149997} } @article{gao2012-22503440, author = {Gao, H. M. and Zhou, H. and Hong, J. S.}, title = {{NADPH oxidases: novel therapeutic targets for neurodegenerative diseases}}, journal = {Trends in pharmacological sciences}, year = {2012}, doi = {10.1016/j.tips.2012.03.008}, pmid = {22503440}, url = {https://doi.org/10.1016/j.tips.2012.03.008} } @article{currais2014-24341874, author = {Currais, A. and Prior, M. and Dargusch, R. and Armando, A. and Ehren, J. and Schubert, D. and Quehenberger, O. and Maher, P.}, title = {{Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice}}, journal = {Aging cell}, year = {2014}, doi = {10.1111/acel.12185}, pmid = {24341874}, url = {https://doi.org/10.1111/acel.12185} } @article{cordle2005-16085653, author = {Cordle, A. and Koenigsknecht-Talboo, J. and Wilkinson, B. and Limpert, A. and Landreth, G.}, title = {{Mechanisms of statin-mediated inhibition of small G-protein function}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m505268200}, pmid = {16085653}, url = {https://doi.org/10.1074/jbc.m505268200} } @article{sheng1998-9542587, author = {Sheng, J. G. and Mrak, R. E. and Griffin, W. S.}, title = {{Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain}}, journal = {Acta neuropathologica}, year = {1998}, doi = {10.1007/s004010050792}, pmid = {9542587}, url = {https://doi.org/10.1007/s004010050792} } @article{mwale2025-39827337, author = {Mwale, Pharaoh Fellow and Hsieh, Cheng-Ta and Yen, Ting‐Lin and Jan, Jing‐Shiun and Taliyan, Rajeev and Yang, Chih‐Hao and Yang, Wen‐Bin}, title = {{Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications}}, journal = {Molecular Neurodegeneration}, year = {2025}, doi = {10.1186/s13024-025-00801-8}, pmid = {39827337}, url = {https://doi.org/10.1186/s13024-025-00801-8} } @article{chia2025-40826098, author = {Chia, Sook‐Yoong and Li, Mengwei and Li, Zigang and Tu, Haitao and Lee, Jolene Wei Ling and Qiu, Lifeng and Ling, Jingjing and Reynolds, Richard J. and others}, title = {{Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes}}, journal = {Genome Medicine}, year = {2025}, doi = {10.1186/s13073-025-01519-4}, pmid = {40826098}, url = {https://doi.org/10.1186/s13073-025-01519-4} } @article{dunfee2006-17015824, author = {Dunfee, R. L. and Thomas, E. R. and Gorry, P. R. and Wang, J. and Taylor, J. and Kunstman, K. and Wolinsky, S. M. and Gabuzda, D.}, title = {{The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2006}, doi = {10.1073/pnas.0605513103}, pmid = {17015824}, url = {https://doi.org/10.1073/pnas.0605513103} } @article{minghetti2004-15453089, author = {Minghetti, L.}, title = {{Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases}}, journal = {Journal of neuropathology and experimental neurology}, year = {2004}, doi = {10.1093/jnen/63.9.901}, pmid = {15453089}, url = {https://doi.org/10.1093/jnen/63.9.901} } @article{minagar2002-12220687, author = {Minagar, A. and Shapshak, P. and Fujimura, R. and Ownby, R. and Heyes, M. and Eisdorfer, C.}, title = {{The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis}}, journal = {Journal of the neurological sciences}, year = {2002}, doi = {10.1016/s0022-510x(02)00207-1}, pmid = {12220687}, url = {https://doi.org/10.1016/s0022-510x(02)00207-1} } @article{pisanu2014-25134730, author = {Pisanu, A. and Lecca, D. and Mulas, G. and Wardas, J. and Simbula, G. and Spiga, S. and Carta, A. R.}, title = {{Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease}}, journal = {Neurobiology of disease}, year = {2014}, doi = {10.1016/j.nbd.2014.08.011}, pmid = {25134730}, url = {https://doi.org/10.1016/j.nbd.2014.08.011} } @article{takeuchi2005-15640150, author = {Takeuchi, H. and Mizuno, T. and Zhang, G. and Wang, J. and Kawanokuchi, J. and Kuno, R. and Suzumura, A.}, title = {{Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m413863200}, pmid = {15640150}, url = {https://doi.org/10.1074/jbc.m413863200} } @article{albright1999-9847323, author = {Albright, A. V. and Shieh, J. T. and Itoh, T. and Lee, B. and Pleasure, D. and O'Connor, M. J. and Doms, R. W. and González-Scarano, F.}, title = {{Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates}}, journal = {Journal of virology}, year = {1999}, doi = {10.1128/jvi.73.1.205-213.1999}, pmid = {9847323}, url = {https://doi.org/10.1128/jvi.73.1.205-213.1999} } @article{tsai2016-27318702, author = {Tsai, H. C. and Han, M. H.}, title = {{Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation}}, journal = {Drugs}, year = {2016}, doi = {10.1007/s40265-016-0603-2}, pmid = {27318702}, url = {https://doi.org/10.1007/s40265-016-0603-2} } @article{ahmad2016-27211305, author = {Ahmad, L. and Zhang, S. Y. and Casanova, J. L. and Sancho-Shimizu, V.}, title = {{Human TBK1: A Gatekeeper of Neuroinflammation}}, journal = {Trends in molecular medicine}, year = {2016}, doi = {10.1016/j.molmed.2016.04.006}, pmid = {27211305}, url = {https://doi.org/10.1016/j.molmed.2016.04.006} } @article{miao2005-16049335, author = {Miao, J. and Xu, F. and Davis, J. and Otte-Höller, I. and Verbeek, M. M. and Van Nostrand, W. E.}, title = {{Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein}}, journal = {The American journal of pathology}, year = {2005}, doi = {10.1016/s0002-9440(10)62993-8}, pmid = {16049335}, url = {https://doi.org/10.1016/s0002-9440(10)62993-8} } @article{ye2025-39806423, author = {Ye, Jinwang and Zhong, Suyue and Wan, Huali and Guo, Xing and Yao, Xuanbao and Liu, Qiong and Chen, Liming and Wang, Jian‐Zhi and others}, title = {{Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis}}, journal = {Molecular Neurodegeneration}, year = {2025}, doi = {10.1186/s13024-025-00796-2}, pmid = {39806423}, url = {https://doi.org/10.1186/s13024-025-00796-2} } @article{petersvanton2020-32592865, author = {Peters van Ton, A. M. and Verbeek, M. M. and Alkema, W. and Pickkers, P. and Abdo, W. F.}, title = {{Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer's disease}}, journal = {Brain, behavior, and immunity}, year = {2020}, doi = {10.1016/j.bbi.2020.06.027}, pmid = {32592865}, url = {https://doi.org/10.1016/j.bbi.2020.06.027} } @article{saha2006-16771683, author = {Saha, R. N. and Pahan, K.}, title = {{Regulation of inducible nitric oxide synthase gene in glial cells}}, journal = {Antioxidants \& redox signaling}, year = {2006}, doi = {10.1089/ars.2006.8.929}, pmid = {16771683}, url = {https://doi.org/10.1089/ars.2006.8.929} } @article{lee2008-18492487, author = {Lee, H. J. and Suk, J. E. and Bae, E. J. and Lee, S. J.}, title = {{Clearance and deposition of extracellular alpha-synuclein aggregates in microglia}}, journal = {Biochemical and biophysical research communications}, year = {2008}, doi = {10.1016/j.bbrc.2008.05.045}, pmid = {18492487}, url = {https://doi.org/10.1016/j.bbrc.2008.05.045} } @article{johnstone1999-10378882, author = {Johnstone, M. and Gearing, A. J. and Miller, K. M.}, title = {{A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced}}, journal = {Journal of neuroimmunology}, year = {1999}, doi = {10.1016/s0165-5728(98)00226-4}, pmid = {10378882}, url = {https://doi.org/10.1016/s0165-5728(98)00226-4} } @article{maezawa2011-20971854, author = {Maezawa, I. and Zimin, P. I. and Wulff, H. and Jin, L. W.}, title = {{Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity}}, journal = {The Journal of biological chemistry}, year = {2011}, doi = {10.1074/jbc.m110.135244}, pmid = {20971854}, url = {https://doi.org/10.1074/jbc.m110.135244} } @article{wang2017-28318352, author = {Wang, D. and Zhang, J. and Jiang, W. and Cao, Z. and Zhao, F. and Cai, T. and Aschner, M. and Luo, W.}, title = {{The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability}}, journal = {Autophagy}, year = {2017}, doi = {10.1080/15548627.2017.1293766}, pmid = {28318352}, url = {https://doi.org/10.1080/15548627.2017.1293766} } @article{schmidtmayerova1996-8570619, author = {Schmidtmayerova, H. and Nottet, H. S. and Nuovo, G. and Raabe, T. and Flanagan, C. R. and Dubrovsky, L. and Gendelman, H. E. and Cerami, A. and others}, title = {{Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1996}, doi = {10.1073/pnas.93.2.700}, pmid = {8570619}, url = {https://doi.org/10.1073/pnas.93.2.700} } @article{hannestad2012-22776451, author = {Hannestad, J. and Gallezot, J. D. and Schafbauer, T. and Lim, K. and Kloczynski, T. and Morris, E. D. and Carson, R. E. and Ding, Y. S. and others}, title = {{Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates}}, journal = {NeuroImage}, year = {2012}, doi = {10.1016/j.neuroimage.2012.06.055}, pmid = {22776451}, url = {https://doi.org/10.1016/j.neuroimage.2012.06.055} } @article{lee2009-19631409, author = {Lee, M. and Schwab, C. and Yu, S. and McGeer, E. and McGeer, P. L.}, title = {{Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide}}, journal = {Neurobiology of aging}, year = {2009}, doi = {10.1016/j.neurobiolaging.2009.06.001}, pmid = {19631409}, url = {https://doi.org/10.1016/j.neurobiolaging.2009.06.001} } @article{giulian1995-7655344, author = {Giulian, D. and Haverkamp, L. J. and Li, J. and Karshin, W. L. and Yu, J. and Tom, D. and Li, X. and Kirkpatrick, J. B.}, title = {{Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain}}, journal = {Neurochemistry international}, year = {1995}, doi = {10.1016/0197-0186(95)00067-i}, pmid = {7655344}, url = {https://doi.org/10.1016/0197-0186(95)00067-i} } @article{yin2010-20667979, author = {Yin, F. and Dumont, M. and Banerjee, R. and Ma, Y. and Li, H. and Lin, M. T. and Beal, M. F. and Nathan, C. and others}, title = {{Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia}}, journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year = {2010}, doi = {10.1096/fj.10-161471}, pmid = {20667979}, url = {https://doi.org/10.1096/fj.10-161471} } @article{akiguchi2017-28261874, author = {Akiguchi, I. and Pallàs, M. and Budka, H. and Akiyama, H. and Ueno, M. and Han, J. and Yagi, H. and Nishikawa, T. and others}, title = {{SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions}}, journal = {Neuropathology : official journal of the Japanese Society of Neuropathology}, year = {2017}, doi = {10.1111/neup.12373}, pmid = {28261874}, url = {https://doi.org/10.1111/neup.12373} } @article{parachikova2008-18258444, author = {Parachikova, A. and Nichol, K. E. and Cotman, C. W.}, title = {{Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition}}, journal = {Neurobiology of disease}, year = {2008}, doi = {10.1016/j.nbd.2007.12.008}, pmid = {18258444}, url = {https://doi.org/10.1016/j.nbd.2007.12.008} } @article{miller2025-40279247, author = {Miller, Cameron R. and Ealy, Alyssa and Gregory, Amanda and Janarthanam, Chelva and Albers, William G and Richardson, Gabriel and Jin, Huajun and Zenitsky, Gary D. and others}, title = {{Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia}}, journal = {Cell Reports}, year = {2025}, doi = {10.1016/j.celrep.2025.115618}, pmid = {40279247}, url = {https://doi.org/10.1016/j.celrep.2025.115618} } @article{arbaciauskaite2026-41678018, author = {Arbaciauskaite, Skaiste and Silvestri, Simona and Luo, Pingyan and Krüger, Christina and Mossmann, Zoé J. and Allelein, Susann and Scholz, Alexander and Löffler, Dennis and others}, title = {{Microglia-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Carry miRNAs Driving a Neuroinflammatory Response}}, journal = {Molecular Neurobiology}, year = {2026}, doi = {10.1007/s12035-026-05719-w}, pmid = {41678018}, url = {https://doi.org/10.1007/s12035-026-05719-w} } @article{seilhean1997-9144590, author = {Seilhean, D. and Kobayashi, K. and He, Y. and Uchihara, T. and Rosenblum, O. and Katlama, C. and Bricaire, F. and Duyckaerts, C. and others}, title = {{Tumor necrosis factor-alpha, microglia and astrocytes in AIDS dementia complex}}, journal = {Acta neuropathologica}, year = {1997}, doi = {10.1007/s004010050646}, pmid = {9144590}, url = {https://doi.org/10.1007/s004010050646} } @article{liu2014-24667364, author = {Liu, Y. and Fu, X. and Lan, N. and Li, S. and Zhang, J. and Wang, S. and Li, C. and Shang, Y. and others}, title = {{Luteolin protects against high fat diet-induced cognitive deficits in obesity mice}}, journal = {Behavioural brain research}, year = {2014}, doi = {10.1016/j.bbr.2014.02.040}, pmid = {24667364}, url = {https://doi.org/10.1016/j.bbr.2014.02.040} } @article{feng2023-37351177, author = {Feng, S. and Wu, C. and Zou, P. and Deng, Q. and Chen, Z. and Li, M. and Zhu, L. and Li, F. and others}, title = {{High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization}}, journal = {Theranostics}, year = {2023}, doi = {10.7150/thno.81951}, pmid = {37351177}, url = {https://doi.org/10.7150/thno.81951} } @article{zhou2023-36989373, author = {Zhou, J. and Wade, S. D. and Graykowski, D. and Xiao, M. F. and Zhao, B. and Giannini, L. A. A. and Hanson, J. E. and van Swieten, J. C. and others}, title = {{The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration}}, journal = {Science translational medicine}, year = {2023}, doi = {10.1126/scitranslmed.adf0141}, pmid = {36989373}, url = {https://doi.org/10.1126/scitranslmed.adf0141} } @article{ranki1995-8527071, author = {Ranki, A. and Nyberg, M. and Ovod, V. and Haltia, M. and Elovaara, I. and Raininko, R. and Haapasalo, H. and Krohn, K.}, title = {{Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia}}, journal = {AIDS (London, England)}, year = {1995}, doi = {10.1097/00002030-199509000-00004}, pmid = {8527071}, url = {https://doi.org/10.1097/00002030-199509000-00004} } @article{cosenza2002-12408230, author = {Cosenza, M. A. and Zhao, M. L. and Si, Q. and Lee, S. C.}, title = {{Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis}}, journal = {Brain pathology (Zurich, Switzerland)}, year = {2002}, doi = {10.1111/j.1750-3639.2002.tb00461.x}, pmid = {12408230}, url = {https://doi.org/10.1111/j.1750-3639.2002.tb00461.x} } @article{matos2008-18790019, author = {Matos, M. and Augusto, E. and Oliveira, C. R. and Agostinho, P.}, title = {{Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades}}, journal = {Neuroscience}, year = {2008}, doi = {10.1016/j.neuroscience.2008.08.022}, pmid = {18790019}, url = {https://doi.org/10.1016/j.neuroscience.2008.08.022} } @article{lunamedina2005-15817469, author = {Luna-Medina, R. and Cortes-Canteli, M. and Alonso, M. and Santos, A. and Martínez, A. and Perez-Castillo, A.}, title = {{Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m414390200}, pmid = {15817469}, url = {https://doi.org/10.1074/jbc.m414390200} } @article{yang2025-40045356, author = {Yang, Qu and Chen, Qi and Zhang, Kai-Bing and Liu, Yu and Zheng, Jia-Cheng and Hu, Dong-Xia and Luo, Jun}, title = {{Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p}}, journal = {Acta Neuropathologica Communications}, year = {2025}, doi = {10.1186/s40478-025-01950-z}, pmid = {40045356}, url = {https://doi.org/10.1186/s40478-025-01950-z} } @article{tsai2026-41516384, author = {Tsai, Hui‐Yun and Qiu, Jing Yi and Liao, Han-Wei and Chang, Chi‐I and Chen, Yu-Hsiang and Ho, Chi‐Tang and Chen, Yu-Kuo and others}, title = {{Propyl Gallate Attenuates Methylglyoxal-Induced Alzheimer-like Cognitive Deficits and Neuroinflammation in Mice}}, journal = {International Journal of Molecular Sciences}, year = {2026}, doi = {10.3390/ijms27010511}, pmid = {41516384}, url = {https://doi.org/10.3390/ijms27010511} } @article{choi2025-40592207, author = {Choi, Jae-Won and Im, Joo Young and Balakrishnan, Rengasamy}, title = {{Paeoniflorin exercise-mimetic potential regulates the Nrf2/HO-1/BDNF/CREB and APP/BACE-1/NF-κB/MAPK signaling pathways to reduce cognitive impairments and neuroinflammation in amnesic mouse model}}, journal = {Biomedicine \& Pharmacotherapy}, year = {2025}, doi = {10.1016/j.biopha.2025.118299}, pmid = {40592207}, url = {https://doi.org/10.1016/j.biopha.2025.118299} } @article{fine2025-39872995, author = {Fine, Jared M. and Kosyakovsky, Jacob and Bowe, Tate T. and Faltesek, Katherine A. and STROEBEL, BENJAMIN M. and Abrahante, Juan E. and Kelly, Michael Robert and Thompson, Elizabeth A. and others}, title = {{Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease}}, journal = {Frontiers in Neuroscience}, year = {2025}, doi = {10.3389/fnins.2024.1528374}, pmid = {39872995}, url = {https://doi.org/10.3389/fnins.2024.1528374} } @article{fischersmith2001-11704885, author = {Fischer-Smith, T. and Croul, S. and Sverstiuk, A. E. and Capini, C. and L'Heureux, D. and Régulier, E. G. and Richardson, M. W. and Amini, S. and others}, title = {{CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection}}, journal = {Journal of neurovirology}, year = {2001}, doi = {10.1080/135502801753248114}, pmid = {11704885}, url = {https://doi.org/10.1080/135502801753248114} } @article{benveniste1990-2121800, author = {Benveniste, E. N. and Sparacio, S. M. and Norris, J. G. and Grenett, H. E. and Fuller, G. M.}, title = {{Induction and regulation of interleukin-6 gene expression in rat astrocytes}}, journal = {Journal of neuroimmunology}, year = {1990}, doi = {10.1016/0165-5728(90)90104-u}, pmid = {2121800}, url = {https://doi.org/10.1016/0165-5728(90)90104-u} } @article{mizuno2004-14975696, author = {Mizuno, T. and Kurotani, T. and Komatsu, Y. and Kawanokuchi, J. and Kato, H. and Mitsuma, N. and Suzumura, A.}, title = {{Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia}}, journal = {Neuropharmacology}, year = {2004}, doi = {10.1016/j.neuropharm.2003.09.009}, pmid = {14975696}, url = {https://doi.org/10.1016/j.neuropharm.2003.09.009} } @article{banisadr2002-12431218, author = {Banisadr, G. and Fontanges, P. and Haour, F. and Kitabgi, P. and Rostène, W. and Mélik Parsadaniantz, S.}, title = {{Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons}}, journal = {The European journal of neuroscience}, year = {2002}, doi = {10.1046/j.1460-9568.2002.02237.x}, pmid = {12431218}, url = {https://doi.org/10.1046/j.1460-9568.2002.02237.x} } @article{yoon2025-40277896, author = {Yoon, Chi‐Su}, title = {{Natural Products in the Treatment of Neuroinflammation at Microglia: Recent Trend and Features}}, journal = {Cells}, year = {2025}, doi = {10.3390/cells14080571}, pmid = {40277896}, url = {https://doi.org/10.3390/cells14080571} } @article{zhai2025-40151913, author = {Zhai, Yanyu and Lu, Kaili and Yuan, Yuan and Zhang, Ziyao and Xue, Lixia and Zhao, Fei and Xu, Xiaofeng and Wang, Hongmei}, title = {{Semaglutide improves cognitive function and neuroinflammation in APP/PS1 transgenic mice by activating AMPK and inhibiting TLR4/NF-κB pathway}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251329439}, pmid = {40151913}, url = {https://doi.org/10.1177/13872877251329439} } @article{zhang2025-39923958, author = {Zhang, Han and Bi, F.H. Tra and Zhao, Peng and Cui, Herong and Tao, Xiaojun and Zhang, Jianghua and Li, Chang and Cao, Yang and others}, title = {{Longan Aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia}}, journal = {Journal of Ethnopharmacology}, year = {2025}, doi = {10.1016/j.jep.2025.119464}, pmid = {39923958}, url = {https://doi.org/10.1016/j.jep.2025.119464} } @article{alami2025-40111935, author = {Alami, Mehdi and Zerif, Echarki and Khalil, Abdelouahed and Hajji, Nabil and Ramassamy, Charles and Lacombe, Guy and Laurent, Benoît and Cohen, Alan A. and others}, title = {{Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ 1–42 -induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251329474}, pmid = {40111935}, url = {https://doi.org/10.1177/13872877251329474} } @article{dematteis2025-40615914, author = {Dematteis, Giulia and Gong, Chunmei and Malecka, Justyna and Tonelli, Elisa and Genazzani, Armando A. and Tapella, Laura and Eleuteri, Anna Maria and Lim, Dmitry and others}, title = {{Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance}}, journal = {Alzheimer s Research \& Therapy}, year = {2025}, doi = {10.1186/s13195-025-01793-9}, pmid = {40615914}, url = {https://doi.org/10.1186/s13195-025-01793-9} } @article{akif2025-40462117, author = {Akif, Adnan and Nguyen, T.T. and Liu, Langni and Xu, Xiaotian and Kulkarni, Amol A. and Jiang, Jianxiong and Zhang, Yang and Hao, Jiukuan}, title = {{Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia}}, journal = {Fluids and Barriers of the CNS}, year = {2025}, doi = {10.1186/s12987-025-00665-6}, pmid = {40462117}, url = {https://doi.org/10.1186/s12987-025-00665-6} } @article{weng2026-41676156, author = {Weng, Ying and He, Ting and Li, Mengzhu and Zhou, Qiuzhi and Xie, Jiazhao and Wei, Linyu and Wang, Xin and Wang, Jian-Zhi and others}, title = {{Microglial histone H3K18 crotonylation promotes STAT1 expression and induces cognitive deficit in Alzheimer disease}}, journal = {Frontiers in Immunology}, year = {2026}, doi = {10.3389/fimmu.2026.1744375}, pmid = {41676156}, url = {https://doi.org/10.3389/fimmu.2026.1744375} } @article{yang2020-32963694, author = {Yang, W. and Liu, Y. and Xu, Q. Q. and Xian, Y. F. and Lin, Z. X.}, title = {{Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease}}, journal = {Oxidative medicine and cellular longevity}, year = {2020}, doi = {10.1155/2020/4754195}, pmid = {32963694}, url = {https://doi.org/10.1155/2020/4754195} } @article{kim2018-30092810, author = {Kim, C. and Spencer, B. and Rockenstein, E. and Yamakado, H. and Mante, M. and Adame, A. and Fields, J. A. and Masliah, D. and others}, title = {{Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation}}, journal = {Molecular neurodegeneration}, year = {2018}, doi = {10.1186/s13024-018-0276-2}, pmid = {30092810}, url = {https://doi.org/10.1186/s13024-018-0276-2} } @article{rosenkranz2007-17582512, author = {Rosenkranz, D. and Weyer, S. and Tolosa, E. and Gaenslen, A. and Berg, D. and Leyhe, T. and Gasser, T. and Stoltze, L.}, title = {{Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration}}, journal = {Journal of neuroimmunology}, year = {2007}, doi = {10.1016/j.jneuroim.2007.05.011}, pmid = {17582512}, url = {https://doi.org/10.1016/j.jneuroim.2007.05.011} } @article{lavi1997-9327737, author = {Lavi, E. and Strizki, J. M. and Ulrich, A. M. and Zhang, W. and Fu, L. and Wang, Q. and O'Connor, M. and Hoxie, J. A. and others}, title = {{CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons}}, journal = {The American journal of pathology}, year = {1997}, pmid = {9327737} } @article{wu2004-15285800, author = {Wu, S. Z. and Bodles, A. M. and Porter, M. M. and Griffin, W. S. and Basile, A. S. and Barger, S. W.}, title = {{Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide}}, journal = {Journal of neuroinflammation}, year = {2004}, doi = {10.1186/1742-2094-1-2}, pmid = {15285800}, url = {https://doi.org/10.1186/1742-2094-1-2} } @article{jaisaaad2025-41436365, author = {Jaisa-aad, Methasit and Agüero, Cinthya and Rabaneda‐Lombarte, Neus and Bianco, Celia and Melloni, Alexandra N. and Hyman, Bradley T. and Gómez‐Isla, Teresa and Brugarolas, Pedro and others}, title = {{Monoamine Oxidase‐B (MAO‐B) Identifies Neurotoxic Reactive Astrocytes in Alzheimer's Disease and Related Dementias}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_102019}, pmid = {41436365}, url = {https://doi.org/10.1002/alz70855_102019} } @article{weiss2025-40816764, author = {Weiss, Blaine E. and Gant, John C. and Lin, Ruei‐Lung and Gollihue, Jenna L. and Rogers, Colin B. and Kraner, Susan D. and Rucker, Edmund B. and Katsumata, Yuriko and others}, title = {{Disrupted Calcium Dynamics in Reactive Astrocytes Occur with End Feet–Arteriole Decoupling in an Amyloid Mouse Model of Alzheimer's Disease}}, journal = {Journal of Neuroscience}, year = {2025}, doi = {10.1523/jneurosci.0349-25.2025}, pmid = {40816764}, url = {https://doi.org/10.1523/jneurosci.0349-25.2025} } @article{zheng2025-40919134, author = {Zheng, Kai and Huang, He‐Zhou and Liu, Dan and Brazhe, Nadezda A. and Chen, Jiajie and Zhu, Ling‐Qiang}, title = {{Targeting the miR‐96‐5p/Cathepsin B Pathway to Alleviate Neuron‐Derived Neuroinflammation in Alzheimer's Disease}}, journal = {MedComm}, year = {2025}, doi = {10.1002/mco2.70368}, pmid = {40919134}, url = {https://doi.org/10.1002/mco2.70368} } @article{song2026-41540503, author = {Song, Chengcheng and Wu, Pau Yen and Huffman, William J. and David‐Bercholz, Jennifer and Bedolla, Alicia and Velagapudi, Ravikanth and Njoroge, Ann Wangechi and Rodriguiz, Ramona M. and others}, title = {{Electrical stimulation of the vagus nerve improves amyloid pathology in delirium superimposed on dementia}}, journal = {Bioelectronic Medicine}, year = {2026}, doi = {10.1186/s42234-025-00194-5}, pmid = {41540503}, url = {https://doi.org/10.1186/s42234-025-00194-5} } @article{rocha2015-26094487, author = {Rocha, E. M. and Smith, G. A. and Park, E. and Cao, H. and Graham, A. R. and Brown, E. and McLean, JR. and Hayes, M. A. and others}, title = {{Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice}}, journal = {Antioxidants \& redox signaling}, year = {2015}, doi = {10.1089/ars.2015.6307}, pmid = {26094487}, url = {https://doi.org/10.1089/ars.2015.6307} } @article{hu2015-25871773, author = {Hu, J. and Liu, C. C. and Chen, X. F. and Zhang, Y. W. and Xu, H. and Bu, G.}, title = {{Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice}}, journal = {Molecular neurodegeneration}, year = {2015}, doi = {10.1186/s13024-015-0001-3}, pmid = {25871773}, url = {https://doi.org/10.1186/s13024-015-0001-3} } @article{lee2010-20972375, author = {Lee, H. J. and Kim, C. and Lee, S. J.}, title = {{Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection}}, journal = {Oxidative medicine and cellular longevity}, year = {2010}, doi = {10.4161/oxim.3.4.12809}, pmid = {20972375}, url = {https://doi.org/10.4161/oxim.3.4.12809} } @article{norenberg1987-3306480, author = {Norenberg, M. D.}, title = {{The role of astrocytes in hepatic encephalopathy}}, journal = {Neurochemical pathology}, year = {1987}, doi = {10.1007/bf02833599}, pmid = {3306480}, url = {https://doi.org/10.1007/bf02833599} } @article{mengr2025-39932627, author = {Mengr, Anna and Šmotková, Zuzana and Pačesová, Andrea and Železná, Blanka and Kuneš, Jaroslav and Maletı́nská, Lenka}, title = {{Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease}}, journal = {Journal of Neuroimmune Pharmacology}, year = {2025}, doi = {10.1007/s11481-025-10174-w}, pmid = {39932627}, url = {https://doi.org/10.1007/s11481-025-10174-w} } @article{liu2025-41013506, author = {Liu, Jiahui and Zaidi, Ali Hussainy and Pike, Christian J.}, title = {{Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity in a sexually dimorphic manner}}, journal = {Journal of Neuroinflammation}, year = {2025}, doi = {10.1186/s12974-025-03534-z}, pmid = {41013506}, url = {https://doi.org/10.1186/s12974-025-03534-z} } @article{abdellah2025-40325262, author = {Abdel-Lah, Ebtsam S and Sherkawy, Hoda S. and Mohamed, Wafaa H. and Fawy, Mariam A. and Hasan, Asmaa A. and Muhammed, Asmaa A. and Taha, Amira F. and Tony, Abeer A. and others}, title = {{Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer’s disease in rats: role of AMPK/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress}}, journal = {Inflammopharmacology}, year = {2025}, doi = {10.1007/s10787-025-01755-5}, pmid = {40325262}, url = {https://doi.org/10.1007/s10787-025-01755-5} } @article{ciervo2026-41499526, author = {Ciervo, Yuri and Rigoni, Pietro and Bucciarelli, Linda and Lombi, Martina and Pratesi, Federico and Bologna, Nadia and Accardo, Massimo and Recchi, Chiara and others}, title = {{Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice}}, journal = {Science Translational Medicine}, year = {2026}, doi = {10.1126/scitranslmed.adw9930}, pmid = {41499526}, url = {https://doi.org/10.1126/scitranslmed.adw9930} } @article{mearelli2025-40888599, author = {Mearelli, Marika and Hirschberg, Insa and Weissleder, Christin and Giachino, Carmela and Maria Jose Perez, J. and Dubroux, Malvina and Provenzano, Francesca and Rizzuti, Mafalda and others}, title = {{C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC ‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk}}, journal = {Glia}, year = {2025}, doi = {10.1002/glia.70080}, pmid = {40888599}, url = {https://doi.org/10.1002/glia.70080} } @article{choe2025-41204331, author = {Choe, Kyonghwan and Ahmad, Riaz and Kang, Min Hwa and Lee, Hyeon Jin and Ahmad, Sareer and Park, Tae Ju and Kim, Myeong Ok}, title = {{The novel sphingolipids cP1P and P1P attenuate neuroinflammation and enhance S1PR1/Akt/mTOR signaling to mitigate cognitive decline in an Alzheimer’s disease mouse model}}, journal = {Cell Communication and Signaling}, year = {2025}, doi = {10.1186/s12964-025-02485-5}, pmid = {41204331}, url = {https://doi.org/10.1186/s12964-025-02485-5} } @article{min2025-41300248, author = {Min, Young and Lee, Yoon-Seob and Lee, Juwon and Keum, Da-Young and Gwag, Joo-Young and Jeon, Soyeon and Jo, Heejin and Kang, Sung-Ung}, title = {{The cGAS–STING Pathway in Dementia: An Emerging Mechanism of Neuroinflammation}}, journal = {Brain Sciences}, year = {2025}, doi = {10.3390/brainsci15111241}, pmid = {41300248}, url = {https://doi.org/10.3390/brainsci15111241} } @article{liu2025-39794619, author = {Liu, Qianshuo and Jiang, Meixi and Wang, Zening and Meng, Jihong and Jia, Hui and Li, Jing and Lin, Jing‐Jer and Guo, Libin and others}, title = {{SENP1 inhibits aerobic glycolysis in Aβ1-42-incubated astrocytes by promoting PUM2 deSUMOylation}}, journal = {Cell Biology and Toxicology}, year = {2025}, doi = {10.1007/s10565-025-09986-6}, pmid = {39794619}, url = {https://doi.org/10.1007/s10565-025-09986-6} } @article{wang2025-39911382, author = {Wang, Xiaohang and Wang, Qianqian and Cai, Zhensheng and Ni, Chengming and Wang, Huan and Liu, Hui and Zhao, Yusong and Wang, Jinbang and others}, title = {{Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice}}, journal = {Frontiers in Immunology}, year = {2025}, doi = {10.3389/fimmu.2025.1503807}, pmid = {39911382}, url = {https://doi.org/10.3389/fimmu.2025.1503807} } @article{zhang2025-40537012, author = {Zhang, Meiyan and Lan, Xiaoyan and Gao, Yue and Li, Shen and Qiao, Guanda and Liang, Yajie and Janowski, Mirosław and Walczak, Piotr and others}, title = {{MCC950 suppresses NLRP3-dependent neuroinflammation and ameliorates cognitive decline in a rat model of cerebral small vessel disease}}, journal = {Neural Regeneration Research}, year = {2025}, doi = {10.4103/nrr.nrr-d-24-01055}, pmid = {40537012}, url = {https://doi.org/10.4103/nrr.nrr-d-24-01055} } @article{lana2025-39835288, author = {Lana, Daniele and Ugolini, Filippo and Iovino, Ludovica and Attorre, Selene and Giovannini, Maria Grazia}, title = {{Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression}}, journal = {Frontiers in Cellular Neuroscience}, year = {2025}, doi = {10.3389/fncel.2024.1512985}, pmid = {39835288}, url = {https://doi.org/10.3389/fncel.2024.1512985} } @article{villanueva2026-42226039, author = {Villanueva, Erika B. and Zebec, Zala and Cisquella-Serra, Marina and Lundstrøm, Jon and Andersen, JB and Qvist, Filippa Liliendahl and Westi, Emil Winther and Marín, Andrea and others}, title = {{Distinct and combined interferon-ɑ/β-receptor-1 loss in neurons and astrocytes disrupt brain energy metabolism and drive Parkinsonian dementia}}, journal = {Journal of Biomedical Science}, year = {2026}, doi = {10.1186/s12929-026-01257-8}, pmid = {42226039}, url = {https://doi.org/10.1186/s12929-026-01257-8} } @article{heavener2025-40987420, author = {Heavener, Kelsey S. and Tamucci, Kirstin A. and Lee, Annie and Kabra, Khushbu and Chatila, Zena K. and Yidenk, Maedot and Bennett, David and Vardarajan, Badri Narayan and others}, title = {{P2RX7 modulates the function of human microglia-like cells and mediates the association of IL18 with Alzheimer's disease traits}}, journal = {Neurobiology of Disease}, year = {2025}, doi = {10.1016/j.nbd.2025.107106}, pmid = {40987420}, url = {https://doi.org/10.1016/j.nbd.2025.107106} } @article{zhang2025-41291718, author = {Zhang, Minjie and You, Tongyao and Guo, Min and Zhao, Yichen and Shen, Weiwei and Jiang, Yanfeng and others}, title = {{Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia}}, journal = {Journal of Nanobiotechnology}, year = {2025}, doi = {10.1186/s12951-025-03838-5}, pmid = {41291718}, url = {https://doi.org/10.1186/s12951-025-03838-5} } @article{arrant2018-29378861, author = {Arrant, A. E. and Onyilo, V. C. and Unger, D. E. and Roberson, E. D.}, title = {{Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2018}, doi = {10.1523/jneurosci.3081-17.2018}, pmid = {29378861}, url = {https://doi.org/10.1523/jneurosci.3081-17.2018} } @article{kim2017-28581123, author = {Kim, J. H. and Ko, P. W. and Lee, H. W. and Jeong, J. Y. and Lee, M. G. and Lee, W. H. and Yu, R. and others}, title = {{Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia}}, journal = {Glia}, year = {2017}, doi = {10.1002/glia.23174}, pmid = {28581123}, url = {https://doi.org/10.1002/glia.23174} } @article{henderson2020-31899072, author = {Henderson, M. X. and Sedor, S. and McGeary, I. and Cornblath, E. J. and Peng, C. and Riddle, D. M. and Li, H. L. and Zhang, B. and others}, title = {{Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult}}, journal = {Neuron}, year = {2020}, doi = {10.1016/j.neuron.2019.12.004}, pmid = {31899072}, url = {https://doi.org/10.1016/j.neuron.2019.12.004} } @article{kour2025-40183098, author = {Kour, Dilpreet and Khajuria, Parul and Sharma, Kuhu and Sharma, Alpa and Sharma, Ankita and Ali, Syed Mudassir and Wazir, Priya and Ramajayan, P. and others}, title = {{Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice}}, journal = {Frontiers in Pharmacology}, year = {2025}, doi = {10.3389/fphar.2025.1525364}, pmid = {40183098}, url = {https://doi.org/10.3389/fphar.2025.1525364} } @article{qi2026-41604700, author = {Qi, Zihe and Li, Qianyu and Cao, Juanjuan and Xu, Bufan and Jiang, Fan and Wang, Yanbo and Wu, Di and Li, Guoliang}, title = {{Chronic Exposure to Thermally Processed Food-Derived Carbon Polymers Accelerated Neuroinflammation in Alzheimer Disease Mice through Microbe–Gut–Brain Axis}}, journal = {Journal of Agricultural and Food Chemistry}, year = {2026}, doi = {10.1021/acs.jafc.5c11423}, pmid = {41604700}, url = {https://doi.org/10.1021/acs.jafc.5c11423} } @article{liu2025-40183082, author = {Liu, Shu and Song, Xiaochen and Sun, Yuefeng and Sun, Ailin and Li, Yang and Li, Yuyu and Chen, Jing}, title = {{Kai-Xin-San ameliorates mild cognitive impairment in SAMP8 mice by inhibiting neuroinflammation and pyroptosis via NLRP3/Caspase-1 pathway modulation}}, journal = {Frontiers in Pharmacology}, year = {2025}, doi = {10.3389/fphar.2025.1528011}, pmid = {40183082}, url = {https://doi.org/10.3389/fphar.2025.1528011} } @article{kiran2025-41373431, author = {Kiran, Sonia and Thilanka, Uvindu and Xue, Yu and Sang, Qing‐Xiang Amy}, title = {{Polystyrene Micro- and Nanoplastic Exposure Triggers an Activation and Stress Response in Human Astrocytes}}, journal = {International Journal of Molecular Sciences}, year = {2025}, doi = {10.3390/ijms262311273}, pmid = {41373431}, url = {https://doi.org/10.3390/ijms262311273} } @article{malenchini2026-42278362, author = {Malenchini, Marta and Beretti, Francesca and Gatti, Martina and Bertucci, Emma and Del Toro, Elena and Maraldi, Tullia}, title = {{Stem Cell-Derived Extracellular Vesicles Ameliorate the Neuron Mitochondrial Damage Induced by ROS-, LPS-Exposure: In Vitro Model of Neuron, Microglia, and Astrocyte Triple Co-Culture}}, journal = {International Journal of Molecular Sciences}, year = {2026}, doi = {10.3390/ijms27114834}, pmid = {42278362}, url = {https://doi.org/10.3390/ijms27114834} } @article{gorry2003-15049431, author = {Gorry, P. R. and Ong, C. and Thorpe, J. and Bannwarth, S. and Thompson, K. A. and Gatignol, A. and Vesselingh, S. L. and Purcell, D. F.}, title = {{Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia}}, journal = {Current HIV research}, year = {2003}, doi = {10.2174/1570162033485122}, pmid = {15049431}, url = {https://doi.org/10.2174/1570162033485122} } @article{xu2025-41138884, author = {Xu, Yuan and Peng, Ya and Zhi, Feng and Yang, Yilin and Li, Jiahui and Fan, Ligang and Xia, Ying and Shao, Nan}, title = {{Delta-opioid receptor ameliorates microglia-induced synapse loss by regulating C1q in Alzheimer disease pathology}}, journal = {Brain Behavior and Immunity}, year = {2025}, doi = {10.1016/j.bbi.2025.106149}, pmid = {41138884}, url = {https://doi.org/10.1016/j.bbi.2025.106149} } @article{yamamoto2025-40707862, author = {Yamamoto, Y. and Kubota, Toshiki and Noguchi, Daisuke and Saido, Takaomi C. and Ohshima, Toshio}, title = {{Co-Expression of Mutant Tau and α-Synuclein in Neurons Promotes Tau Phosphorylation, Neuronal Loss, and Neuroinflammation in Mouse Brain}}, journal = {Molecular Neurobiology}, year = {2025}, doi = {10.1007/s12035-025-05248-y}, pmid = {40707862}, url = {https://doi.org/10.1007/s12035-025-05248-y} } @article{graur2025-39992414, author = {Graur, Alexandru and Erickson, Natalie and Sinclair, Patricia and Nusir, Aya and Kabbani, Nadine}, title = {{HIV-1 gp120 Interactions with Nicotine Modulate Mitochondrial Network Properties and Amyloid Release in Microglia}}, journal = {Neurochemical Research}, year = {2025}, doi = {10.1007/s11064-025-04357-3}, pmid = {39992414}, url = {https://doi.org/10.1007/s11064-025-04357-3} } @article{dunacka2025-40283962, author = {Dunacka, Joanna and Grembecka, Beata and Majkutewicz, Irena and Wrona, Danuta}, title = {{Central Insulin-like Growth Factor-1 Treatment Enhances Working and Reference Memory by Reducing Neuroinflammation and Amyloid Beta Deposition in a Rat Model of Sporadic Alzheimer’s Disease}}, journal = {Pharmaceuticals}, year = {2025}, doi = {10.3390/ph18040527}, pmid = {40283962}, url = {https://doi.org/10.3390/ph18040527} } @article{masegosa2025-40671688, author = {Masegosa, Vera M. and Fritz, Elsa and Corvalán, Daniela and Rojas, Fabiola and Garcés, Polett and Navarro, Xavier and Bloms‐Funke, Petra and van Zundert, Brigitte and others}, title = {{Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media}}, journal = {ACS Chemical Neuroscience}, year = {2025}, doi = {10.1021/acschemneuro.5c00197}, pmid = {40671688}, url = {https://doi.org/10.1021/acschemneuro.5c00197} } @article{pluta2025-41245147, author = {Pluta, Ryszard M.}, title = {{Direct and indirect role of non-coding RNAs in company with amyloid and tau protein in promoting neuroinflammation in post-ischemic brain neurodegeneration}}, journal = {Frontiers in Cellular Neuroscience}, year = {2025}, doi = {10.3389/fncel.2025.1670462}, pmid = {41245147}, url = {https://doi.org/10.3389/fncel.2025.1670462} } @article{yang2025-39834810, author = {Yang, Chaokai and Zhao, Enlong and Zhang, Hu and Duan, Li-Qi and Han, Xinyue and Ding, Hongli and Cheng, Yan and Wang, Dengkun and others}, title = {{Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflammation}}, journal = {Frontiers in Pharmacology}, year = {2025}, doi = {10.3389/fphar.2024.1508726}, pmid = {39834810}, url = {https://doi.org/10.3389/fphar.2024.1508726} } @article{chauhan2003-12551932, author = {Chauhan, A. and Turchan, J. and Pocernich, C. and Bruce-Keller, A. and Roth, S. and Butterfield, D. A. and Major, E. O. and Nath, A.}, title = {{Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport}}, journal = {The Journal of biological chemistry}, year = {2003}, doi = {10.1074/jbc.m209381200}, pmid = {12551932}, url = {https://doi.org/10.1074/jbc.m209381200} } @article{leszek2016-26831258, author = {Leszek, J. and Barreto, G. E. and Gąsiorowski, K. and Koutsouraki, E. and Ávila-Rodrigues, M. and Aliev, G.}, title = {{Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System}}, journal = {CNS \& neurological disorders drug targets}, year = {2016}, doi = {10.2174/1871527315666160202125914}, pmid = {26831258}, url = {https://doi.org/10.2174/1871527315666160202125914} } @article{sahm2013-23548271, author = {Sahm, F. and Oezen, I. and Opitz, C. A. and Radlwimmer, B. and von Deimling, A. and Ahrendt, T. and Adams, S. and Bode, H. B. and others}, title = {{The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress}}, journal = {Cancer research}, year = {2013}, doi = {10.1158/0008-5472.can-12-3831}, pmid = {23548271}, url = {https://doi.org/10.1158/0008-5472.can-12-3831} } @article{vanmarle2004-15518810, author = {van Marle, G. and Henry, S. and Todoruk, T. and Sullivan, A. and Silva, C. and Rourke, S. B. and Holden, J. and McArthur, J. C. and others}, title = {{Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10}}, journal = {Virology}, year = {2004}, doi = {10.1016/j.virol.2004.08.024}, pmid = {15518810}, url = {https://doi.org/10.1016/j.virol.2004.08.024} } @article{zheng2008-18279803, author = {Zheng, L. T. and Ock, J. and Kwon, B. M. and Suk, K.}, title = {{Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity}}, journal = {International immunopharmacology}, year = {2008}, doi = {10.1016/j.intimp.2007.12.012}, pmid = {18279803}, url = {https://doi.org/10.1016/j.intimp.2007.12.012} } @article{hwang2008-18639562, author = {Hwang, J. and Zheng, L. T. and Ock, J. and Lee, M. G. and Kim, S. H. and Lee, H. W. and Lee, W. H. and Park, H. C. and others}, title = {{Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants}}, journal = {Neuropharmacology}, year = {2008}, doi = {10.1016/j.neuropharm.2008.06.045}, pmid = {18639562}, url = {https://doi.org/10.1016/j.neuropharm.2008.06.045} } @article{takata2010-20947502, author = {Takata, K. and Kitamura, Y. and Saeki, M. and Terada, M. and Kagitani, S. and Kitamura, R. and Fujikawa, Y. and Maelicke, A. and others}, title = {{Galantamine-induced amyloid-beta clearance mediated via stimulation of microglial nicotinic acetylcholine receptors}}, journal = {The Journal of biological chemistry}, year = {2010}, doi = {10.1074/jbc.m110.142356}, pmid = {20947502}, url = {https://doi.org/10.1074/jbc.m110.142356} } @article{guillemin2003-12555204, author = {Guillemin, G. J. and Croitoru-Lamoury, J. and Dormont, D. and Armati, P. J. and Brew, B. J.}, title = {{Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes}}, journal = {Glia}, year = {2003}, doi = {10.1002/glia.10175}, pmid = {12555204}, url = {https://doi.org/10.1002/glia.10175} } @article{gurwell2001-11226693, author = {Gurwell, J. A. and Nath, A. and Sun, Q. and Zhang, J. and Martin, K. M. and Chen, Y. and Hauser, K. F.}, title = {{Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro}}, journal = {Neuroscience}, year = {2001}, doi = {10.1016/s0306-4522(00)00461-9}, pmid = {11226693}, url = {https://doi.org/10.1016/s0306-4522(00)00461-9} } @article{chaudhuri2008-18003888, author = {Chaudhuri, A. and Yang, B. and Gendelman, H. E. and Persidsky, Y. and Kanmogne, G. D.}, title = {{STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier}}, journal = {Blood}, year = {2008}, doi = {10.1182/blood-2007-05-091207}, pmid = {18003888}, url = {https://doi.org/10.1182/blood-2007-05-091207} } @article{jia2026-22fe2677, author = {Jia, Yanli and Ren, Yanyan and Yu, Yunmei and Dong, Fangming and Geng, Minxia and Feng, Rongfang}, title = {{SHP2 in microglia attenuates neuroinflammation and cognitive deficits in vascular dementia by modulating the FAK/Src/PU. 1/IRF8 pathway}}, journal = {European journal of medical research}, year = {2026}, doi = {10.1186/s40001-026-04317-9}, url = {https://doi.org/10.1186/s40001-026-04317-9} } @article{cantone2025-39918606, author = {Cantone, Anna Flavia and Burgaletto, Chiara and Di Benedetto, Giulia and Gaudio, Gabriella and Giallongo, Cesarina and Caltabiano, Rosario and Broggi, Giuseppe and Bellanca, Carlo Maria and others}, title = {{Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer’s Disease}}, journal = {Journal of Neuroimmune Pharmacology}, year = {2025}, doi = {10.1007/s11481-025-10177-7}, pmid = {39918606}, url = {https://doi.org/10.1007/s11481-025-10177-7} } @article{shou2026-41935066, author = {Shou, Rongshang and Wang, Ziyue and Han, Zige and Li, Anyao and Shang, Jiaxin and Lou, HaiYue and Zhang, Xiaotong and Zhan, Yingqi and others}, title = {{Dietary silver nanoparticle supplementation induces Alzheimer-like lesions through Bifidobacterium deficiency-dominated gut microbiota dysbiosis and neuroinflammation}}, journal = {npj Science of Food}, year = {2026}, doi = {10.1038/s41538-026-00820-9}, pmid = {41935066}, url = {https://doi.org/10.1038/s41538-026-00820-9} } @article{wan2025-39791204, author = {Wan, Tianchi and Wang, Chunkai}, title = {{SMOC2 promotes microglia activity and neuroinflammation in Alzheimer's disease}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877241307337}, pmid = {39791204}, url = {https://doi.org/10.1177/13872877241307337} } @article{shaw2025-41191004, author = {Shaw, Benjamin C. F. and Kaiser, Kaitlin E. and Smith, Brandon C. and Timken, J Payton and Louveau, Antoine and Williams, Jessica Lynn}, title = {{Astrocytes upregulate interleukin-15 in response to neuroinflammation during Alzheimer's disease}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251393275}, pmid = {41191004}, url = {https://doi.org/10.1177/13872877251393275} } @article{heimfarth2025-41439604, author = {Heimfarth, Luana and Ribeiro, Felipe Campos and Fortuna, Juliana T S and Stelzer, Gustavo Trevizani and Ferreira, Sergio Teixeira}, title = {{Irisin attenuates astrocyte activation and rescues memory in Alzheimer model mice}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_104063}, pmid = {41439604}, url = {https://doi.org/10.1002/alz70855_104063} } @article{wang2025-41291751, author = {Wang, Xinliang and Liu, Xiaoxi and Zhang, Wenyu and Qi, Shige and Li, Jinyan and Li, Ruiyu and Guo, Jingxin and Zhang, Yifan and others}, title = {{Acupuncture reduces neuroinflammation and apoptosis, regulates peripheral immunity, and modulates T-cell subset distribution in vascular dementia rats}}, journal = {Chinese Medicine}, year = {2025}, doi = {10.1186/s13020-025-01243-6}, pmid = {41291751}, url = {https://doi.org/10.1186/s13020-025-01243-6} }