% alzhub.org library filter % Source: https://alzhub.org/research?category=inflammation&atag=nlrp3 % 140 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{holmes2009-19738171, author = {Holmes, C. and Cunningham, C. and Zotova, E. and Woolford, J. and Dean, C. and Kerr, S. and Culliford, D. and Perry, V. H.}, title = {{Systemic inflammation and disease progression in Alzheimer disease}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181b6bb95}, pmid = {19738171}, url = {https://doi.org/10.1212/wnl.0b013e3181b6bb95} } @article{ouyang2026-42150695, author = {Ouyang, Xiaoxue and Chia, Rachel S L and Chai, Yuek Ling and Chong, Joyce R and Sim, Ming Ann and Jo, Dong-Gyu and Arumugam, Thiruma V and Sethi, Gautam and others}, title = {{Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia}}, journal = {Biochemical pharmacology}, year = {2026}, doi = {10.1016/j.bcp.2026.118077}, pmid = {42150695}, url = {https://doi.org/10.1016/j.bcp.2026.118077} } @article{gaire2026-41571675, author = {Gaire, Bhakta Prasad and Koronyo, Yosef and Vit, Jean-Philippe and Hutton, Alexandre and Subedi, Lalita and Fuchs, Dieu-Trang and Swerdlow, Natalie and Rentsendorj, Altan and others}, title = {{Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina}}, journal = {Nature communications}, year = {2026}, doi = {10.1038/s41467-026-68580-4}, pmid = {41571675}, url = {https://doi.org/10.1038/s41467-026-68580-4} } @article{lee2026-41789727, author = {Lee, Jeongmi and Cho, Yongeun and Choi, Bo Youn and Kim, Hark Kyun and Lee, Yeongyeong and Kim, Eunae and Han, Jihoon and Sul, Jae Hoon and others}, title = {{HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2026}, doi = {10.1093/brain/awag089}, pmid = {41789727}, url = {https://doi.org/10.1093/brain/awag089} } @article{shen2026-42489128, author = {Shen, Qi and Chang, Haocai and Li, Junyu and Guo, Haoyun and Shi, Wenbin and Yan, Yihua and Ouyang, Wenwen and Zhang, Zhan and others}, title = {{Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models}}, journal = {Brain : a journal of neurology}, year = {2026}, doi = {10.1093/brain/awag247}, pmid = {42489128}, url = {https://doi.org/10.1093/brain/awag247} } @article{wendeln2018-29643512, author = {Wendeln, A. C. and Degenhardt, K. and Kaurani, L. and Gertig, M. and Ulas, T. and Jain, G. and Wagner, J. and Häsler, L. M. and others}, title = {{Innate immune memory in the brain shapes neurological disease hallmarks}}, journal = {Nature}, year = {2018}, doi = {10.1038/s41586-018-0023-4}, pmid = {29643512}, url = {https://doi.org/10.1038/s41586-018-0023-4} } @article{hartmann2024-38528004, author = {Hartmann, Jakob and Bajaj, Thomas and Otten, Joy and Klengel, Claudia and Ebert, Tim and Gellner, Anne-Kathrin and Junglas, Ellen and Hafner, Kathrin and others}, title = {{SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration}}, journal = {Nature communications}, year = {2024}, doi = {10.1038/s41467-024-46953-x}, pmid = {38528004}, url = {https://doi.org/10.1038/s41467-024-46953-x} } @article{riversauty2024-39229486, author = {Rivers-Auty, Jack and Hoyle, Christopher and Pointer, Ayesha and Lawrence, Catherine and Pickering-Brown, Stuart and Brough, David and Ryan, Sarah}, title = {{C9orf72 dipeptides activate the NLRP3 inflammasome}}, journal = {Brain communications}, year = {2024}, doi = {10.1093/braincomms/fcae282}, pmid = {39229486}, url = {https://doi.org/10.1093/braincomms/fcae282} } @article{spangenberg2019-31434879, author = {Spangenberg, E. and Severson, P. L. and Hohsfield, L. A. and Crapser, J. and Zhang, J. and Burton, E. A. and Zhang, Y. and Spevak, W. and others}, title = {{Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model}}, journal = {Nature communications}, year = {2019}, doi = {10.1038/s41467-019-11674-z}, pmid = {31434879}, url = {https://doi.org/10.1038/s41467-019-11674-z} } @article{moonen2023-36481964, author = {Moonen, Sebastiaan and Koper, Marta J and Van Schoor, Evelien and Schaeverbeke, Jolien M and Vandenberghe, Rik and von Arnim, Christine A F and Tousseyn, Thomas and De Strooper, Bart and others}, title = {{Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons}}, journal = {Acta neuropathologica}, year = {2023}, doi = {10.1007/s00401-022-02528-y}, pmid = {36481964}, url = {https://doi.org/10.1007/s00401-022-02528-y} } @article{zeenny2026-42377782, author = {Zeenny, Marie-Noel and Salame, Ingrid and Maatouk, Lynn and Akoury, Elias}, title = {{Neuroinflammation and Tauopathies}}, journal = {Molecular biology reports}, year = {2026}, doi = {10.1007/s11033-026-12253-4}, pmid = {42377782}, url = {https://doi.org/10.1007/s11033-026-12253-4} } @article{chou2023-38016942, author = {Chou, Vicky and Pearse, Richard V and Aylward, Aimee J and Ashour, Nancy and Taga, Mariko and Terzioglu, Gizem and Fujita, Masashi and Fancher, Seeley B and others}, title = {{INPP5D regulates inflammasome activation in human microglia}}, journal = {Nature communications}, year = {2023}, doi = {10.1038/s41467-023-42819-w}, pmid = {38016942}, url = {https://doi.org/10.1038/s41467-023-42819-w} } @article{lopezrodriguez2021-34080771, author = {Lopez-Rodriguez, Ana Belen and Hennessy, Edel and Murray, Carol L and Nazmi, Arshed and Delaney, Hugh J and Healy, Dáire and Fagan, Steven G and Rooney, Michael and others}, title = {{Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2021}, doi = {10.1002/alz.12341}, pmid = {34080771}, url = {https://doi.org/10.1002/alz.12341} } @article{kim2026-41673711, author = {Kim, Yeji and Ha, Tae-Young and Kondaurova, Oksana and Lee, Myung-Shik and Chang, Keun-A}, title = {{Microglia TFEB activation attenuates Alzheimer's disease pathology by enhancing autophagy-lysosomal function}}, journal = {Journal of neuroinflammation}, year = {2026}, doi = {10.1186/s12974-026-03728-z}, pmid = {41673711}, url = {https://doi.org/10.1186/s12974-026-03728-z} } @article{chen2023-36835494, author = {Chen, Yi-Chun and Chang, Shih-Cheng and Lee, Yun-Shien and Ho, Wei-Min and Huang, Yu-Hua and Wu, Yah-Yuan and Chu, Yi-Chuan and Wu, Kuan-Hsuan and others}, title = {{TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease}}, journal = {International journal of molecular sciences}, year = {2023}, doi = {10.3390/ijms24044085}, pmid = {36835494}, url = {https://doi.org/10.3390/ijms24044085} } @article{kim2021-33382892, author = {Kim, Jong-Heon and Afridi, Ruqayya and Han, Jin and Jung, Hyun-Gug and Kim, Seung-Chan and Hwang, Eun Mi and Shim, Hyun Soo and Ryu, Hoon and others}, title = {{Gamma subunit of complement component 8 is a neuroinflammation inhibitor}}, journal = {Brain : a journal of neurology}, year = {2021}, doi = {10.1093/brain/awaa425}, pmid = {33382892}, url = {https://doi.org/10.1093/brain/awaa425} } @article{yao2023-37670126, author = {Yao, Jing and Wang, Zhe and Song, Weihong and Zhang, Yun}, title = {{Targeting NLRP3 inflammasome for neurodegenerative disorders}}, journal = {Molecular psychiatry}, year = {2023}, doi = {10.1038/s41380-023-02239-0}, pmid = {37670126}, url = {https://doi.org/10.1038/s41380-023-02239-0} } @article{li2026-41734021, author = {Li, Tao and Castro-Gomez, Sergio and Lucena, Pablo Botella and Vieira-Saecker, Ana and Schwartz, Stephanie and Ding, Yingying and Deng, Yushuang and Gou, Maling and others}, title = {{Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model}}, journal = {The Journal of clinical investigation}, year = {2026}, doi = {10.1172/jci199818}, pmid = {41734021}, url = {https://doi.org/10.1172/jci199818} } @article{salter2017-28886007, author = {Salter, M. W. and Stevens, B.}, title = {{Microglia emerge as central players in brain disease}}, journal = {Nature medicine}, year = {2017}, doi = {10.1038/nm.4397}, pmid = {28886007}, url = {https://doi.org/10.1038/nm.4397} } @article{zhang2023-37433768, author = {Zhang, W. and Xiao, D. and Mao, Q. and Xia, H.}, title = {{Role of neuroinflammation in neurodegeneration development}}, journal = {Signal transduction and targeted therapy}, year = {2023}, doi = {10.1038/s41392-023-01486-5}, pmid = {37433768}, url = {https://doi.org/10.1038/s41392-023-01486-5} } @article{guo2022-35250543, author = {Guo, S. and Wang, H. and Yin, Y.}, title = {{Microglia Polarization From M1 to M2 in Neurodegenerative Diseases}}, journal = {Frontiers in aging neuroscience}, year = {2022}, doi = {10.3389/fnagi.2022.815347}, pmid = {35250543}, url = {https://doi.org/10.3389/fnagi.2022.815347} } @article{xu2025-40075143, author = {Xu, Wen and Huang, Yi and Zhou, Rongbin}, title = {{NLRP3 inflammasome in neuroinflammation and central nervous system diseases}}, journal = {Cellular \& molecular immunology}, year = {2025}, doi = {10.1038/s41423-025-01275-w}, pmid = {40075143}, url = {https://doi.org/10.1038/s41423-025-01275-w} } @article{li2025-40260242, author = {Li, Zhitao and Gong, Chunrong}, title = {{NLRP3 inflammasome in Alzheimer's disease: molecular mechanisms and emerging therapies}}, journal = {Frontiers in immunology}, year = {2025}, doi = {10.3389/fimmu.2025.1583886}, pmid = {40260242}, url = {https://doi.org/10.3389/fimmu.2025.1583886} } @article{verma2024-38507186, author = {Verma, Ambika and Azhar, Gohar and Patyal, Pankaj and Zhang, Wei and Zhang, Xiaomin and Wei, Jeanne Y}, title = {{Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells}}, journal = {GeroScience}, year = {2024}, doi = {10.1007/s11357-024-01117-z}, pmid = {38507186}, url = {https://doi.org/10.1007/s11357-024-01117-z} } @article{wang2025-40847374, author = {Wang, Jie and Ni, Hong and Wang, Yu and Wei, Luyao and Ding, Hanqing and Guo, Zhongzhao and Pan, Hao and Yu, Ying and others}, title = {{Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment}}, journal = {Translational neurodegeneration}, year = {2025}, doi = {10.1186/s40035-025-00501-9}, pmid = {40847374}, url = {https://doi.org/10.1186/s40035-025-00501-9} } @article{guo2025-40541122, author = {Guo, Minsong and Wang, Zhengqin and Zhou, Xiaogang and Yu, Chonglin and Wu, Jianming and Yu, Lu and Mi, Jianing and Ren, Fang and others}, title = {{Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation}}, journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology}, year = {2025}, doi = {10.1016/j.phymed.2025.156928}, pmid = {40541122}, url = {https://doi.org/10.1016/j.phymed.2025.156928} } @article{vilella2024-37967665, author = {Vilella, Antonietta and Bodria, Martina and Papotti, Bianca and Zanotti, Ilaria and Zimetti, Francesca and Remaggi, Giulia and Elviri, Lisa and Potì, Francesco and others}, title = {{PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice}}, journal = {Brain, behavior, and immunity}, year = {2024}, doi = {10.1016/j.bbi.2023.11.008}, pmid = {37967665}, url = {https://doi.org/10.1016/j.bbi.2023.11.008} } @article{xu2025-41175591, author = {Xu, Ziwei and Huang, Feijun and Wu, Zheming and Xu, Ke and Huang, Liping}, title = {{Syringin attenuates Alzheimer's disease-associated neuroinflammation by inhibiting NLRP3 inflammasome activation}}, journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology}, year = {2025}, doi = {10.1016/j.phymed.2025.157454}, pmid = {41175591}, url = {https://doi.org/10.1016/j.phymed.2025.157454} } @article{joshi2024-39215356, author = {Joshi, Radhika and Brezani, Veronika and Mey, Gabrielle M and Guixé-Muntet, Sergi and Ortega-Ribera, Marti and Zhuang, Yuan and Zivny, Adam and Werneburg, Sebastian and others}, title = {{IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease}}, journal = {Journal of neuroinflammation}, year = {2024}, doi = {10.1186/s12974-024-03203-7}, pmid = {39215356}, url = {https://doi.org/10.1186/s12974-024-03203-7} } @article{li2024-38043010, author = {Li, Yunfeng and Chen, Xiongjin and Zhou, Mulan and Feng, Sifan and Peng, Xiaoping and Wang, Yan}, title = {{Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2024}, doi = {10.3233/jad-230273}, pmid = {38043010}, url = {https://doi.org/10.3233/jad-230273} } @article{ravichandran2025-41206011, author = {Ravichandran, Kishore Aravind and Brosseron, Frederic and McManus, Róisín M and Ising, Christina and Görgen, Simon and Schmidt, Susanne V and Santarelli, Fracesco and Lee, Se Young and others}, title = {{Enhancing Tyro3 signaling ameliorates IL-1β production through STAT1 in Alzheimer's disease models}}, journal = {Journal of leukocyte biology}, year = {2025}, doi = {10.1093/jleuko/qiaf157}, pmid = {41206011}, url = {https://doi.org/10.1093/jleuko/qiaf157} } @article{han2025-40400619, author = {Han, Jialin and Zhang, Zhi and Zhang, Pengfei and Yu, Qian and Cheng, Qian and Lu, Zhiming and Zong, Shuai}, title = {{The roles of microglia and astrocytes in neuroinflammation of Alzheimer's disease}}, journal = {Frontiers in neuroscience}, year = {2025}, doi = {10.3389/fnins.2025.1575453}, pmid = {40400619}, url = {https://doi.org/10.3389/fnins.2025.1575453} } @article{serradas2024-39272998, author = {Serradas, Maria L and Ding, Yingying and Martorell, Paula V and Kulińska, Ida and Castro-Gomez, Sergio}, title = {{Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease}}, journal = {Cells}, year = {2024}, doi = {10.3390/cells13171426}, pmid = {39272998}, url = {https://doi.org/10.3390/cells13171426} } @article{braatz2024-36799439, author = {Braatz, Charlotte and Komes, Max P and Ravichandran, Kishore Aravind and de Fragas, Matheus Garcia and Griep, Angelika and Schwartz, Stephanie and McManus, Róisín M and Heneka, Michael T}, title = {{NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro}}, journal = {Journal of neurochemistry}, year = {2024}, doi = {10.1111/jnc.15778}, pmid = {36799439}, url = {https://doi.org/10.1111/jnc.15778} } @article{wang2025-41062518, author = {Wang, Xiaoxuan and Tian, Haozhe and Chen, Shifei and Ying, Liangliang and Zheng, Juan and Song, Yaya and Xi, Jin and Zhang, Yuxin and others}, title = {{Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells}}, journal = {Scientific reports}, year = {2025}, doi = {10.1038/s41598-025-19015-5}, pmid = {41062518}, url = {https://doi.org/10.1038/s41598-025-19015-5} } @article{maphis2015-25833819, author = {Maphis, Nicole M. and Xu, Guixiang and Kokiko‐Cochran, Olga N. and Jiang, Shanya and Cardona, Astrid E. and Ransohoff, Richard M. and Lamb, Bruce T. and Bhaskar, Kiran}, title = {{Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain}}, journal = {Brain}, year = {2015}, doi = {10.1093/brain/awv081}, pmid = {25833819}, url = {https://doi.org/10.1093/brain/awv081} } @article{kwon2020-33239064, author = {Kwon, H. S. and Koh, S. H.}, title = {{Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes}}, journal = {Translational neurodegeneration}, year = {2020}, doi = {10.1186/s40035-020-00221-2}, pmid = {33239064}, url = {https://doi.org/10.1186/s40035-020-00221-2} } @article{meda1995-7715705, author = {Meda, L. and Cassatella, M. A. and Szendrei, G. I. and Otvos, L. and Baron, P. and Villalba, M. and Ferrari, D. and Rossi, F.}, title = {{Activation of microglial cells by beta-amyloid protein and interferon-gamma}}, journal = {Nature}, year = {1995}, doi = {10.1038/374647a0}, pmid = {7715705}, url = {https://doi.org/10.1038/374647a0} } @article{zhang2019-30936558, author = {Zhang, P. and Kishimoto, Y. and Grammatikakis, I. and Gottimukkala, K. and Cutler, R. G. and Zhang, S. and Abdelmohsen, K. and Bohr, V. A. and others}, title = {{Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-019-0372-9}, pmid = {30936558}, url = {https://doi.org/10.1038/s41593-019-0372-9} } @article{simpson2020-32823544, author = {Simpson, D. S. A. and Oliver, P. L.}, title = {{ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease}}, journal = {Antioxidants (Basel, Switzerland)}, year = {2020}, doi = {10.3390/antiox9080743}, pmid = {32823544}, url = {https://doi.org/10.3390/antiox9080743} } @article{merighi2022-36361780, author = {Merighi, Stefania and Nigro, Manuela and Travagli, Alessia and Gessi, Stefania}, title = {{Microglia and Alzheimer's Disease}}, journal = {International journal of molecular sciences}, year = {2022}, doi = {10.3390/ijms232112990}, pmid = {36361780}, url = {https://doi.org/10.3390/ijms232112990} } @article{kim2021-34638977, author = {Kim, Jieun and Lee, Hyun-Ju and Park, Seon Kyeong and Park, Jin-Hee and Jeong, Ha-Ram and Lee, Soojung and Lee, Heeyong and Seol, Eunyoung and others}, title = {{Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling}}, journal = {International journal of molecular sciences}, year = {2021}, doi = {10.3390/ijms221910637}, pmid = {34638977}, url = {https://doi.org/10.3390/ijms221910637} } @article{freitag2022-35780157, author = {Freitag, Kiara and Sterczyk, Nele and Wendlinger, Sarah and Obermayer, Benedikt and Schulz, Julia and Farztdinov, Vadim and Mülleder, Michael and Ralser, Markus and others}, title = {{Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model}}, journal = {Journal of neuroinflammation}, year = {2022}, doi = {10.1186/s12974-022-02534-7}, pmid = {35780157}, url = {https://doi.org/10.1186/s12974-022-02534-7} } @article{dedios2023-36895045, author = {de Dios, Cristina and Abadin, Xenia and Roca-Agujetas, Vicente and Jimenez-Martinez, Marina and Morales, Albert and Trullas, Ramon and Mari, Montserrat and Colell, Anna}, title = {{Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis}}, journal = {Translational neurodegeneration}, year = {2023}, doi = {10.1186/s40035-023-00343-3}, pmid = {36895045}, url = {https://doi.org/10.1186/s40035-023-00343-3} } @article{gong2022-36017373, author = {Gong, Ting and Chen, Qi and Mao, Hongchen and Zhang, Yao and Ren, Huan and Xu, Mengmeng and Chen, Hong and Yang, Deqin}, title = {{Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice}}, journal = {Frontiers in cellular and infection microbiology}, year = {2022}, doi = {10.3389/fcimb.2022.925435}, pmid = {36017373}, url = {https://doi.org/10.3389/fcimb.2022.925435} } @article{li2023-37165444, author = {Li, Jia-Mei and Hu, Ting and Zhou, Xiao-Na and Zhang, Ting and Guo, Jia-Hui and Wang, Min-Yuan and Wu, Yi-Lin and Su, Wen-Jun and others}, title = {{The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice}}, journal = {Journal of neuroinflammation}, year = {2023}, doi = {10.1186/s12974-023-02791-0}, pmid = {37165444}, url = {https://doi.org/10.1186/s12974-023-02791-0} } @article{shah2021-34948444, author = {Shah, Akash and Kishore, Uday and Shastri, Abhishek}, title = {{Complement System in Alzheimer's Disease}}, journal = {International journal of molecular sciences}, year = {2021}, doi = {10.3390/ijms222413647}, pmid = {34948444}, url = {https://doi.org/10.3390/ijms222413647} } @article{shu2023-36800288, author = {Shu, Xiaoqiu and Wei, Chen and Tu, Wen-Yo and Zhong, Keke and Qi, Shuyuan and Wang, Ailian and Bai, Lei and Zhang, Shan-Xin and others}, title = {{Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome}}, journal = {Cell reports}, year = {2023}, doi = {10.1016/j.celrep.2023.112133}, pmid = {36800288}, url = {https://doi.org/10.1016/j.celrep.2023.112133} } @article{vanzeller2021-34366341, author = {Van Zeller, Mariana and Dias, Diogo and Sebastião, Ana M and Valente, Cláudia A}, title = {{NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2021}, doi = {10.3233/jad-210268}, pmid = {34366341}, url = {https://doi.org/10.3233/jad-210268} } @article{ravichandran2021-34846519, author = {Ravichandran, Kishore Aravind and Heneka, Michael T}, title = {{Inflammasome activation in neurodegenerative diseases}}, journal = {Essays in biochemistry}, year = {2021}, doi = {10.1042/ebc20210021}, pmid = {34846519}, url = {https://doi.org/10.1042/ebc20210021} } @article{barczuk2022-36012243, author = {Barczuk, Julia and Siwecka, Natalia and Lusa, Weronika and Rozpędek-Kamińska, Wioletta and Kucharska, Ewa and Majsterek, Ireneusz}, title = {{Targeting NLRP3-Mediated Neuroinflammation in Alzheimer's Disease Treatment}}, journal = {International journal of molecular sciences}, year = {2022}, doi = {10.3390/ijms23168979}, pmid = {36012243}, url = {https://doi.org/10.3390/ijms23168979} } @article{zhou2023-37268807, author = {Zhou, Ran and Chen, Shih-Heng and Zhao, Zhan and Tu, Dezhen and Song, Sheng and Wang, Yubao and Wang, Qingshan and Feng, Jing and others}, title = {{Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway}}, journal = {Molecular neurobiology}, year = {2023}, doi = {10.1007/s12035-023-03393-w}, pmid = {37268807}, url = {https://doi.org/10.1007/s12035-023-03393-w} } @article{holbrook2021-33776778, author = {Holbrook, Jonathan A and Jarosz-Griffiths, Heledd H and Caseley, Emily and Lara-Reyna, Samuel and Poulter, James A and Williams-Gray, Caroline H and Peckham, Daniel and McDermott, Michael F}, title = {{Neurodegenerative Disease and the NLRP3 Inflammasome}}, journal = {Frontiers in pharmacology}, year = {2021}, doi = {10.3389/fphar.2021.643254}, pmid = {33776778}, url = {https://doi.org/10.3389/fphar.2021.643254} } @article{rather2021-34381308, author = {Rather, Mashoque Ahmad and Khan, Andleeb and Alshahrani, Saeed and Rashid, Hina and Qadri, Marwa and Rashid, Summya and Alsaffar, Rana M and Kamal, Mohammad Amjad and others}, title = {{Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products}}, journal = {Mediators of inflammation}, year = {2021}, doi = {10.1155/2021/9982954}, pmid = {34381308}, url = {https://doi.org/10.1155/2021/9982954} } @article{zhang2021-34430820, author = {Zhang, Liansheng and Qian, Yun and Li, Jie and Zhou, Xuan and Xu, He and Yan, Jie and Xiang, Jialing and Yuan, Xiang and others}, title = {{BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology}}, journal = {iScience}, year = {2021}, doi = {10.1016/j.isci.2021.102942}, pmid = {34430820}, url = {https://doi.org/10.1016/j.isci.2021.102942} } @article{lee2021-34668411, author = {Lee, SangJoon and Cho, Hyun-Jeong and Ryu, Jin-Hyeob}, title = {{Innate Immunity and Cell Death in Alzheimer's Disease}}, journal = {ASN neuro}, year = {2021}, doi = {10.1177/17590914211051908}, pmid = {34668411}, url = {https://doi.org/10.1177/17590914211051908} } @article{milner2021-33181351, author = {Milner, Mark T and Maddugoda, Madhavi and Götz, Jürgen and Burgener, Sabrina S and Schroder, Kate}, title = {{The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease}}, journal = {Current opinion in immunology}, year = {2021}, doi = {10.1016/j.coi.2020.10.011}, pmid = {33181351}, url = {https://doi.org/10.1016/j.coi.2020.10.011} } @article{toscano2021-34530705, author = {Toscano, Eliana C de Brito and Rocha, Natalia P and Lopes, Beatriz N A and Suemoto, Claudia K and Teixeira, Antonio L}, title = {{Neuroinflammation in Alzheimer's Disease: Focus on NLRP1 and NLRP3 Inflammasomes}}, journal = {Current protein \& peptide science}, year = {2021}, doi = {10.2174/1389203722666210916141436}, pmid = {34530705}, url = {https://doi.org/10.2174/1389203722666210916141436} } @article{gao2023-37328043, author = {Gao, Dan and Hao, Jin-Ping and Li, Bo-Ya and Zheng, Ceng-Ceng and Miao, Bei-Bei and Zhang, Li and Li, Ya-Li and Li, Lin and others}, title = {{Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING}}, journal = {European journal of pharmacology}, year = {2023}, doi = {10.1016/j.ejphar.2023.175809}, pmid = {37328043}, url = {https://doi.org/10.1016/j.ejphar.2023.175809} } @article{sandhu2021-33499208, author = {Sandhu, Jagdeep K and Kulka, Marianna}, title = {{Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases}}, journal = {International journal of molecular sciences}, year = {2021}, doi = {10.3390/ijms22031093}, pmid = {33499208}, url = {https://doi.org/10.3390/ijms22031093} } @article{mamsa2023-37652164, author = {Mamsa, Rumaiza and Prabhavalkar, Kedar S and Bhatt, Lokesh Kumar}, title = {{Crosstalk between NLRP3 inflammasome and calpain in Alzheimer's disease}}, journal = {The European journal of neuroscience}, year = {2023}, doi = {10.1111/ejn.16139}, pmid = {37652164}, url = {https://doi.org/10.1111/ejn.16139} } @article{trudler2021-33833060, author = {Trudler, Dorit and Nazor, Kristopher L and Eisele, Yvonne S and Grabauskas, Titas and Dolatabadi, Nima and Parker, James and Sultan, Abdullah and Zhong, Zhenyu and others}, title = {{Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2021}, doi = {10.1073/pnas.2025847118}, pmid = {33833060}, url = {https://doi.org/10.1073/pnas.2025847118} } @article{lei2021-33641782, author = {Lei, Li-Yan and Wang, Rui-Cheng and Pan, Ya-Lei and Yue, Zheng-Gang and Zhou, Rui and Xie, Pei and Tang, Zhi-Shu}, title = {{Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway}}, journal = {Chinese journal of natural medicines}, year = {2021}, doi = {10.1016/s1875-5364(21)60012-2}, pmid = {33641782}, url = {https://doi.org/10.1016/s1875-5364(21)60012-2} } @article{brahadeeswaran2022-35066762, author = {Brahadeeswaran, Subhashini and Sivagurunathan, Narmadhaa and Calivarathan, Latchoumycandane}, title = {{Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases}}, journal = {Molecular neurobiology}, year = {2022}, doi = {10.1007/s12035-021-02683-5}, pmid = {35066762}, url = {https://doi.org/10.1007/s12035-021-02683-5} } @article{jia2023-37721665, author = {Jia, Yue-Ran and Guo, Zi-Qing and Guo, Qian and Wang, Xiao-Chuan}, title = {{Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer's Disease}}, journal = {Current medical science}, year = {2023}, doi = {10.1007/s11596-023-2788-4}, pmid = {37721665}, url = {https://doi.org/10.1007/s11596-023-2788-4} } @article{han2023-37725102, author = {Han, Ying-Hao and Liu, Xiao-Dong and Jin, Mei-Hua and Sun, Hu-Nan and Kwon, Taeho}, title = {{Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases}}, journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]}, year = {2023}, doi = {10.1007/s00011-023-01790-4}, pmid = {37725102}, url = {https://doi.org/10.1007/s00011-023-01790-4} } @article{xu2021-34187889, author = {Xu, Yin and Propson, Nicholas E and Du, Shuqi and Xiong, Wen and Zheng, Hui}, title = {{Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2021}, doi = {10.1073/pnas.2023418118}, pmid = {34187889}, url = {https://doi.org/10.1073/pnas.2023418118} } @article{bohlson2023-36750318, author = {Bohlson, Suzanne S and Tenner, Andrea J}, title = {{Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation}}, journal = {Annual review of immunology}, year = {2023}, doi = {10.1146/annurev-immunol-101921-035639}, pmid = {36750318}, url = {https://doi.org/10.1146/annurev-immunol-101921-035639} } @article{chen2023-36018184, author = {Chen, Feng and Liu, Jing and Li, Fa-Qiang and Wang, Shuai-Shuai and Zhang, Yan-Yan and Lu, Yun-Yun and Hu, Fang-Fang and Yao, Rui-Qin}, title = {{β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats}}, journal = {Neural regeneration research}, year = {2023}, doi = {10.4103/1673-5374.350204}, pmid = {36018184}, url = {https://doi.org/10.4103/1673-5374.350204} } @article{golzarisorkheh2021-34569958, author = {Golzari-Sorkheh, Mahdieh and Brown, Carla E and Weaver, Donald F and Reed, Mark A}, title = {{The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer's Disease}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2021}, doi = {10.3233/jad-210660}, pmid = {34569958}, url = {https://doi.org/10.3233/jad-210660} } @article{jung2022-35474599, author = {Jung, Eun Sun and Suh, Kyujin and Han, Jihui and Kim, Heyyoung and Kang, Hyung-Sik and Choi, Won-Seok and Mook-Jung, Inhee}, title = {{Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway}}, journal = {Aging cell}, year = {2022}, doi = {10.1111/acel.13623}, pmid = {35474599}, url = {https://doi.org/10.1111/acel.13623} } @article{sita2021-34209586, author = {Sita, Giulia and Graziosi, Agnese and Hrelia, Patrizia and Morroni, Fabiana}, title = {{NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration}}, journal = {International journal of molecular sciences}, year = {2021}, doi = {10.3390/ijms22136984}, pmid = {34209586}, url = {https://doi.org/10.3390/ijms22136984} } @article{ghosh2021-34656693, author = {Ghosh, Powsali and Singh, Ravi and Ganeshpurkar, Ankit and Pokle, Ankit Vyankatrao and Singh, Ravi Bhushan and Singh, Sushil Kumar and Kumar, Ashok}, title = {{Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts \& roles}}, journal = {Neurochemistry international}, year = {2021}, doi = {10.1016/j.neuint.2021.105212}, pmid = {34656693}, url = {https://doi.org/10.1016/j.neuint.2021.105212} } @article{streit2004-15285801, author = {Streit, W. J. and Mrak, R. E. and Griffin, W. S.}, title = {{Microglia and neuroinflammation: a pathological perspective}}, journal = {Journal of neuroinflammation}, year = {2004}, doi = {10.1186/1742-2094-1-14}, pmid = {15285801}, url = {https://doi.org/10.1186/1742-2094-1-14} } @article{pan2022-35303422, author = {Pan, R. Y. and He, L. and Zhang, J. and Liu, X. and Liao, Y. and Gao, J. and Yan, Y. and others}, title = {{Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease}}, journal = {Cell metabolism}, year = {2022}, doi = {10.1016/j.cmet.2022.02.013}, pmid = {35303422}, url = {https://doi.org/10.1016/j.cmet.2022.02.013} } @article{mccoy2008-18925972, author = {McCoy, M. K. and Tansey, M. G.}, title = {{TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease}}, journal = {Journal of neuroinflammation}, year = {2008}, doi = {10.1186/1742-2094-5-45}, pmid = {18925972}, url = {https://doi.org/10.1186/1742-2094-5-45} } @article{pekny2016-26671410, author = {Pekny, M. and Pekna, M. and Messing, A. and Steinhäuser, C. and Lee, J. M. and Parpura, V. and Hol, E. M. and Sofroniew, M. V. and others}, title = {{Astrocytes: a central element in neurological diseases}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-015-1513-1}, pmid = {26671410}, url = {https://doi.org/10.1007/s00401-015-1513-1} } @article{hofman1989-2754393, author = {Hofman, Florence M. and Hinton, David R. and Johnson, K. P. and Merrill, J E}, title = {{Tumor necrosis factor identified in multiple sclerosis brain}}, journal = {The Journal of Experimental Medicine}, year = {1989}, doi = {10.1084/jem.170.2.607}, pmid = {2754393}, url = {https://doi.org/10.1084/jem.170.2.607} } @article{cunningham2005-16207887, author = {Cunningham, Colm M. and Wilcockson, David Charles and Campion, Suzanne and Lunnon, Katie and Perry, Victor Hugh}, title = {{Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration}}, journal = {Journal of Neuroscience}, year = {2005}, doi = {10.1523/jneurosci.2614-05.2005}, pmid = {16207887}, url = {https://doi.org/10.1523/jneurosci.2614-05.2005} } @article{frankcannon2009-19917131, author = {Frank-Cannon, Tamy C. and Alto, Laura Taylor and McAlpine, Fiona E and Tansey, Malú G.}, title = {{Does neuroinflammation fan the flame in neurodegenerative diseases?}}, journal = {Molecular Neurodegeneration}, year = {2009}, doi = {10.1186/1750-1326-4-47}, pmid = {19917131}, url = {https://doi.org/10.1186/1750-1326-4-47} } @article{selmaj1991-1999503, author = {Selmaj, Krzysztof W. and Raine, Cedric S. and Cannella, Barbara and Brosnan, Celia F.}, title = {{Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions}}, journal = {Journal of Clinical Investigation}, year = {1991}, doi = {10.1172/jci115102}, pmid = {1999503}, url = {https://doi.org/10.1172/jci115102} } @article{combs2001-11160388, author = {Combs, Colin Kelly and Karlo, J. Colleen and Kao, Shih-Chu and Landreth, Gary E.}, title = {{β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis}}, journal = {Journal of Neuroscience}, year = {2001}, doi = {10.1523/jneurosci.21-04-01179.2001}, pmid = {11160388}, url = {https://doi.org/10.1523/jneurosci.21-04-01179.2001} } @article{paresce1996-8816718, author = {Paresce, Donata M. and Ghosh, Richik N. and Maxfield, Frederick R.}, title = {{Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor}}, journal = {Neuron}, year = {1996}, doi = {10.1016/s0896-6273(00)80187-7}, pmid = {8816718}, url = {https://doi.org/10.1016/s0896-6273(00)80187-7} } @article{chiu2013-23850290, author = {Chiu, Isaac M. and Morimoto, Emiko and Goodarzi, Hani and Liao, Jennifer T. and O’Keeffe, Sean and Phatnani, Hemali P. and Muratet, Michael A. and Carroll, Michael C. and others}, title = {{A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model}}, journal = {Cell Reports}, year = {2013}, doi = {10.1016/j.celrep.2013.06.018}, pmid = {23850290}, url = {https://doi.org/10.1016/j.celrep.2013.06.018} } @article{benito2003-14657172, author = {Benito, Cristina and Núñez, Estefanía and Tolón, Rosa Maria and Carrier, Erica J. and Rábano, Alberto and Hillard, Cecilia J. and Romero, Julián}, title = {{Cannabinoid CB2Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains}}, journal = {Journal of Neuroscience}, year = {2003}, doi = {10.1523/jneurosci.23-35-11136.2003}, pmid = {14657172}, url = {https://doi.org/10.1523/jneurosci.23-35-11136.2003} } @article{frautschy1998-9422548, author = {Frautschy, Sally Ann and Yang, F and Irrizarry, Michael and Hyman, Bradley T. and Saido, Takaomi C. and Hsiao, Karen and Cole, Greg M.}, title = {{Microglial response to amyloid plaques in APPsw transgenic mice}}, journal = {Europe PMC (PubMed Central)}, year = {1998}, pmid = {9422548} } @article{lian2016-26758846, author = {Lian, Hong and Litvinchuk, Alexandra and Chiang, Angie C.A. and Aithmitti, Nadia and Jankowsky, Joanna L. and Zheng, Hui}, title = {{Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease}}, journal = {Journal of Neuroscience}, year = {2016}, doi = {10.1523/jneurosci.2117-15.2016}, pmid = {26758846}, url = {https://doi.org/10.1523/jneurosci.2117-15.2016} } @article{reedgeaghan2009-19776284, author = {Reed-Geaghan, Erin G. and Savage, Julie C. and Hise, Amy G. and Landreth, Gary E.}, title = {{CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation}}, journal = {Journal of Neuroscience}, year = {2009}, doi = {10.1523/jneurosci.3158-09.2009}, pmid = {19776284}, url = {https://doi.org/10.1523/jneurosci.3158-09.2009} } @article{venegas2019-31702392, author = {Venegas, Carmen and Heneka, Michael T}, title = {{Inflammasome-mediated innate immunity in Alzheimer's disease}}, journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year = {2019}, doi = {10.1096/fj.201900439}, pmid = {31702392}, url = {https://doi.org/10.1096/fj.201900439} } @article{pereira2019-31577960, author = {Pereira, Claudia F and Santos, Armanda E and Moreira, Paula I and Pereira, Ana Catarina and Sousa, Fabio J and Cardoso, Sandra M and Cruz, M Teresa}, title = {{Is Alzheimer's disease an inflammasomopathy?}}, journal = {Ageing research reviews}, year = {2019}, doi = {10.1016/j.arr.2019.100966}, pmid = {31577960}, url = {https://doi.org/10.1016/j.arr.2019.100966} } @article{heneka2017-28019679, author = {Heneka, Michael T}, title = {{Inflammasome activation and innate immunity in Alzheimer's disease}}, journal = {Brain pathology (Zurich, Switzerland)}, year = {2017}, doi = {10.1111/bpa.12483}, pmid = {28019679}, url = {https://doi.org/10.1111/bpa.12483} } @article{giorgi2020-33207731, author = {Giorgi, Filippo Sean and Biagioni, Francesca and Galgani, Alessandro and Pavese, Nicola and Lazzeri, Gloria and Fornai, Francesco}, title = {{Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia}}, journal = {International journal of molecular sciences}, year = {2020}, doi = {10.3390/ijms21228630}, pmid = {33207731}, url = {https://doi.org/10.3390/ijms21228630} } @article{dinet2019-31780883, author = {Dinet, Virginie and Petry, Klaus G and Badaut, Jerome}, title = {{Brain-Immune Interactions and Neuroinflammation After Traumatic Brain Injury}}, journal = {Frontiers in neuroscience}, year = {2019}, doi = {10.3389/fnins.2019.01178}, pmid = {31780883}, url = {https://doi.org/10.3389/fnins.2019.01178} } @article{ho2020-31786775, author = {Ho, Wen-Chien and Hsu, Chia-Chi and Huang, Hui-Ju and Wang, Hsiang-Tsui and Lin, Anya Maan-Yuh}, title = {{Anti-inflammatory Effect of AZD6244 on Acrolein-Induced Neuroinflammation}}, journal = {Molecular neurobiology}, year = {2020}, doi = {10.1007/s12035-019-01758-8}, pmid = {31786775}, url = {https://doi.org/10.1007/s12035-019-01758-8} } @article{tzeng2018-30127003, author = {Tzeng, Te-Chen and Hasegawa, Yuto and Iguchi, Risa and Cheung, Amy and Caffrey, Daniel R and Thatcher, Elizabeth Jeanne and Mao, Wenjie and Germain, Gail and others}, title = {{Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2018}, doi = {10.1073/pnas.1801802115}, pmid = {30127003}, url = {https://doi.org/10.1073/pnas.1801802115} } @article{pennisi2017-27862176, author = {Pennisi, Manuela and Crupi, Rosalia and Di Paola, Rosanna and Ontario, Maria Laura and Bella, Rita and Calabrese, Edward J and Crea, Roberto and Cuzzocrea, Salvatore and others}, title = {{Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease}}, journal = {Journal of neuroscience research}, year = {2017}, doi = {10.1002/jnr.23986}, pmid = {27862176}, url = {https://doi.org/10.1002/jnr.23986} } @article{marttinen2018-30618585, author = {Marttinen, Mikael and Takalo, Mari and Natunen, Teemu and Wittrahm, Rebekka and Gabbouj, Sami and Kemppainen, Susanna and Leinonen, Ville and Tanila, Heikki and others}, title = {{Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease}}, journal = {Frontiers in neuroscience}, year = {2018}, doi = {10.3389/fnins.2018.00963}, pmid = {30618585}, url = {https://doi.org/10.3389/fnins.2018.00963} } @article{meszaros2020-32635451, author = {Mészáros, Ádám and Molnár, Kinga and Nógrádi, Bernát and Hernádi, Zsófia and Nyúl-Tóth, Ádám and Wilhelm, Imola and Krizbai, István A}, title = {{Neurovascular Inflammaging in Health and Disease}}, journal = {Cells}, year = {2020}, doi = {10.3390/cells9071614}, pmid = {32635451}, url = {https://doi.org/10.3390/cells9071614} } @article{dansokho2018-29273951, author = {Dansokho, Cira and Heneka, Michael Thomas}, title = {{Neuroinflammatory responses in Alzheimer's disease}}, journal = {Journal of neural transmission (Vienna, Austria : 1996)}, year = {2018}, doi = {10.1007/s00702-017-1831-7}, pmid = {29273951}, url = {https://doi.org/10.1007/s00702-017-1831-7} } @article{guan2020-32792920, author = {Guan, Yadi and Han, Fang}, title = {{Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases}}, journal = {Frontiers in integrative neuroscience}, year = {2020}, doi = {10.3389/fnint.2020.00037}, pmid = {32792920}, url = {https://doi.org/10.3389/fnint.2020.00037} } @article{larosa2019-31594217, author = {La Rosa, Francesca and Saresella, Marina and Marventano, Ivana and Piancone, Federica and Ripamonti, Enrico and Al-Daghri, Nasser and Bazzini, Chiara and Zoia, Chiara Paola and others}, title = {{Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2019}, doi = {10.3233/jad-181259}, pmid = {31594217}, url = {https://doi.org/10.3233/jad-181259} } @article{yang2020-32391019, author = {Yang, Junling and Wise, Leslie and Fukuchi, Ken-Ichiro}, title = {{TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease}}, journal = {Frontiers in immunology}, year = {2020}, doi = {10.3389/fimmu.2020.00724}, pmid = {32391019}, url = {https://doi.org/10.3389/fimmu.2020.00724} } @article{matsuda2015-ebf754c6, author = {Matsuda, Taito and Murao, Naoya and Katano, Yuki and Juliandi, Berry and Kohyama, Jun and Akira, Shizuo and Kawai, Taro and Nakashima, Kinichi}, title = {{TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus}}, journal = {Nature Communications}, year = {2015}, doi = {10.1038/ncomms7514}, url = {https://doi.org/10.1038/ncomms7514} } @article{abud2017-28426964, author = {Abud, E. M. and Ramirez, R. N. and Martinez, E. S. and Healy, L. M. and Nguyen, C. H. H. and Newman, S. A. and Yeromin, A. V. and Scarfone, V. M. and others}, title = {{iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases}}, journal = {Neuron}, year = {2017}, doi = {10.1016/j.neuron.2017.03.042}, pmid = {28426964}, url = {https://doi.org/10.1016/j.neuron.2017.03.042} } @article{stephenson2018-29513402, author = {Stephenson, J. and Nutma, E. and van der Valk, P. and Amor, S.}, title = {{Inflammation in CNS neurodegenerative diseases}}, journal = {Immunology}, year = {2018}, doi = {10.1111/imm.12922}, pmid = {29513402}, url = {https://doi.org/10.1111/imm.12922} } @article{baik2019-31257151, author = {Baik, S. H. and Kang, S. and Lee, W. and Choi, H. and Chung, S. and Kim, J. I. and Mook-Jung, I.}, title = {{A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease}}, journal = {Cell metabolism}, year = {2019}, doi = {10.1016/j.cmet.2019.06.005}, pmid = {31257151}, url = {https://doi.org/10.1016/j.cmet.2019.06.005} } @article{subhramanyam2019-31077796, author = {Subhramanyam, C. S. and Wang, C. and Hu, Q. and Dheen, S. T.}, title = {{Microglia-mediated neuroinflammation in neurodegenerative diseases}}, journal = {Seminars in cell \& developmental biology}, year = {2019}, doi = {10.1016/j.semcdb.2019.05.004}, pmid = {31077796}, url = {https://doi.org/10.1016/j.semcdb.2019.05.004} } @article{mcgeer2000-10961418, author = {McGeer, P L and McGeer, E G and Yasojima, K}, title = {{Alzheimer disease and neuroinflammation}}, journal = {Journal of neural transmission. Supplementum}, year = {2000}, doi = {10.1007/978-3-7091-6781-6_8}, pmid = {10961418}, url = {https://doi.org/10.1007/978-3-7091-6781-6_8} } @article{saresella2016-26939933, author = {Saresella, Marina and La Rosa, Francesca and Piancone, Federica and Zoppis, Martina and Marventano, Ivana and Calabrese, Elena and Rainone, Veronica and Nemni, Raffaello and others}, title = {{The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2016}, doi = {10.1186/s13024-016-0088-1}, pmid = {26939933}, url = {https://doi.org/10.1186/s13024-016-0088-1} } @article{alvarezerviti2011-21423189, author = {Alvarez-Erviti, L. and Seow, Y. and Yin, H. and Betts, C. and Lakhal, S. and Wood, M. J.}, title = {{Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes}}, journal = {Nature biotechnology}, year = {2011}, doi = {10.1038/nbt.1807}, pmid = {21423189}, url = {https://doi.org/10.1038/nbt.1807} } @article{glass2010-20303880, author = {Glass, C. K. and Saijo, K. and Winner, B. and Marchetto, M. C. and Gage, F. H.}, title = {{Mechanisms underlying inflammation in neurodegeneration}}, journal = {Cell}, year = {2010}, doi = {10.1016/j.cell.2010.02.016}, pmid = {20303880}, url = {https://doi.org/10.1016/j.cell.2010.02.016} } @article{halle2008-18604209, author = {Halle, A. and Hornung, V. and Petzold, G. C. and Stewart, C. R. and Monks, B. G. and Reinheckel, T. and Fitzgerald, K. A. and Latz, E. and others}, title = {{The NALP3 inflammasome is involved in the innate immune response to amyloid-beta}}, journal = {Nature immunology}, year = {2008}, doi = {10.1038/ni.1636}, pmid = {18604209}, url = {https://doi.org/10.1038/ni.1636} } @article{tang2016-25598354, author = {Tang, Y. and Le, W.}, title = {{Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases}}, journal = {Molecular neurobiology}, year = {2016}, doi = {10.1007/s12035-014-9070-5}, pmid = {25598354}, url = {https://doi.org/10.1007/s12035-014-9070-5} } @article{amor2010-20561356, author = {Amor, S. and Puentes, F. and Baker, D. and van der Valk, P.}, title = {{Inflammation in neurodegenerative diseases}}, journal = {Immunology}, year = {2010}, doi = {10.1111/j.1365-2567.2009.03225.x}, pmid = {20561356}, url = {https://doi.org/10.1111/j.1365-2567.2009.03225.x} } @article{lucas2006-16402109, author = {Lucas, S. M. and Rothwell, N. J. and Gibson, R. M.}, title = {{The role of inflammation in CNS injury and disease}}, journal = {British journal of pharmacology}, year = {2006}, doi = {10.1038/sj.bjp.0706400}, pmid = {16402109}, url = {https://doi.org/10.1038/sj.bjp.0706400} } @article{kim2015-25690731, author = {Kim, E. K. and Choi, E. J.}, title = {{Compromised MAPK signaling in human diseases: an update}}, journal = {Archives of toxicology}, year = {2015}, doi = {10.1007/s00204-015-1472-2}, pmid = {25690731}, url = {https://doi.org/10.1007/s00204-015-1472-2} } @article{liu2003-12490568, author = {Liu, B. and Hong, J. S.}, title = {{Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention}}, journal = {The Journal of pharmacology and experimental therapeutics}, year = {2003}, doi = {10.1124/jpet.102.035048}, pmid = {12490568}, url = {https://doi.org/10.1124/jpet.102.035048} } @article{wang2015-26207229, author = {Wang, W. Y. and Tan, M. S. and Yu, J. T. and Tan, L.}, title = {{Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease}}, journal = {Annals of translational medicine}, year = {2015}, doi = {10.3978/j.issn.2305-5839.2015.03.49}, pmid = {26207229}, url = {https://doi.org/10.3978/j.issn.2305-5839.2015.03.49} } @article{tansey2010-19913097, author = {Tansey, M. G. and Goldberg, M. S.}, title = {{Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention}}, journal = {Neurobiology of disease}, year = {2010}, doi = {10.1016/j.nbd.2009.11.004}, pmid = {19913097}, url = {https://doi.org/10.1016/j.nbd.2009.11.004} } @article{gonzalezscarano1999-10202538, author = {González-Scarano, F. and Baltuch, G.}, title = {{Microglia as mediators of inflammatory and degenerative diseases}}, journal = {Annual review of neuroscience}, year = {1999}, doi = {10.1146/annurev.neuro.22.1.219}, pmid = {10202538}, url = {https://doi.org/10.1146/annurev.neuro.22.1.219} } @article{boche2013-23252647, author = {Boche, D. and Perry, V. H. and Nicoll, J. A.}, title = {{Review: activation patterns of microglia and their identification in the human brain}}, journal = {Neuropathology and applied neurobiology}, year = {2013}, doi = {10.1111/nan.12011}, pmid = {23252647}, url = {https://doi.org/10.1111/nan.12011} } @article{streit2002-12379901, author = {Streit, W. J.}, title = {{Microglia as neuroprotective, immunocompetent cells of the CNS}}, journal = {Glia}, year = {2002}, doi = {10.1002/glia.10154}, pmid = {12379901}, url = {https://doi.org/10.1002/glia.10154} } @article{heneka2015-25689443, author = {Heneka, M. T. and Golenbock, D. T. and Latz, E.}, title = {{Innate immunity in Alzheimer's disease}}, journal = {Nature immunology}, year = {2015}, doi = {10.1038/ni.3102}, pmid = {25689443}, url = {https://doi.org/10.1038/ni.3102} } @article{elhage2015-84bbe974, author = {El-Hage, Nazira and Rodriguez, Myosotys and Dever, Seth M. and Masvekar, Ruturaj R. and Gewirtz, David A. and Shacka, John J.}, title = {{HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse}}, journal = {Journal of Virology}, year = {2015}, doi = {10.1128/jvi.02022-14}, url = {https://doi.org/10.1128/jvi.02022-14} } @article{carroll2015-a3cc5d37, author = {Carroll, James A. and Striebel, James F. and Race, Brent and Phillips, Katie and Chesebro, Bruce}, title = {{Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction}}, journal = {Journal of Virology}, year = {2015}, doi = {10.1128/jvi.02952-14}, url = {https://doi.org/10.1128/jvi.02952-14} } @article{cho2015-e082a2d8, author = {Cho, Seo-Hyun and Chen, Jason A. and Sayed, Faten and Ward, Michael E. and Gao, Fuying and Nguyen, Thi A. and Krabbe, Grietje and Sohn, Peter Dongmin and others}, title = {{SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β}}, journal = {The Journal of Neuroscience}, year = {2015}, doi = {10.1523/jneurosci.2939-14.2015}, url = {https://doi.org/10.1523/jneurosci.2939-14.2015} } @article{cox2015-0d3a0b26, author = {Cox, Donal J. and Field, Robert H. and Williams, David G. and Baran, Marcin and Bowie, Andrew G. and Cunningham, Colm and Dunne, Aisling}, title = {{DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease}}, journal = {Glia}, year = {2015}, doi = {10.1002/glia.22786}, url = {https://doi.org/10.1002/glia.22786} } @article{haim2015-fb6262b5, author = {Haim, Lucile Ben and Ceyzériat, Kelly and Sauvage, Maria Angeles Carrillo-de and Aubry, Fabien and Auregan, Gwennaëlle and Guillermier, Martine and Ruiz, Marta and Petit, Fanny and others}, title = {{The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases}}, journal = {The Journal of Neuroscience}, year = {2015}, doi = {10.1523/jneurosci.3516-14.2015}, url = {https://doi.org/10.1523/jneurosci.3516-14.2015} } @article{carretrebillat2015-79617690, author = {Carret-Rebillat, Anne-Sophie and Pace, Clarisse and Gourmaud, Sarah and Ravasi, Laura and Montagne-Stora, Samantha and Longueville, Sophie and Tible, Marion and Sudol, Erika and others}, title = {{Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation}}, journal = {Scientific Reports}, year = {2015}, doi = {10.1038/srep08489}, url = {https://doi.org/10.1038/srep08489} } @article{li2015-7e58f8dc, author = {Li, Matthew D. and Burns, Terry C. and Kumar, Sunny and Morgan, Alexander A. and Sloan, Steven A. and Palmer, Theo D.}, title = {{Aging‐like changes in the transcriptome of irradiated microglia}}, journal = {Glia}, year = {2015}, doi = {10.1002/glia.22782}, url = {https://doi.org/10.1002/glia.22782} } @article{biesmans2015-5f2cd130, author = {Biesmans, Steven and Acton, Paul D. and Cotto, Carlos and Langlois, Xavier and Donck, Luc Ver and Bouwknecht, Jan A. and Aelvoet, Sarah‐Ann and Hellings, Niels and others}, title = {{Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap‐luc mice}}, journal = {Glia}, year = {2015}, doi = {10.1002/glia.22804}, url = {https://doi.org/10.1002/glia.22804} } @article{brown2015-602808b8, author = {Brown, Amanda}, title = {{Understanding the MIND phenotype: macrophage/microglia inflammation in neurocognitive disorders related to human immunodeficiency virus infection}}, journal = {Clinical and Translational Medicine}, year = {2015}, doi = {10.1186/s40169-015-0049-2}, url = {https://doi.org/10.1186/s40169-015-0049-2} } @article{kamphuis2015-ea259c45, author = {Kamphuis, Willem and Kooijman, Lieneke and Orre, Marie and Stassen, Oscar and Pekny, Milos and Hol, Elly M.}, title = {{GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for A lzheimer's disease}}, journal = {Glia}, year = {2015}, doi = {10.1002/glia.22800}, url = {https://doi.org/10.1002/glia.22800} } @article{bosco2015-6869bfb1, author = {Bosco, Alejandra and Romero, Cesar O. and Breen, Kevin T. and Chagovetz, Alexis A. and Steele, Michael R. and Ambati, Balamurali K. and Vetter, Monica L.}, title = {{Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma}}, journal = {Disease Models \& Mechanisms}, year = {2015}, doi = {10.1242/dmm.018788}, url = {https://doi.org/10.1242/dmm.018788} } @article{chou2023-36865139, author = {Chou, Vicky and Fancher, Seeley B and Pearse, Richard V and Lee, Hyo and Lam, Matti and Seyfried, Nicholas T and Bennett, David A and De Jager, Phillip L and others}, title = {{INPP5D/SHIP1 regulates inflammasome activation in human microglia}}, journal = {bioRxiv : the preprint server for biology}, year = {2023}, doi = {10.1101/2023.02.25.530025}, pmid = {36865139}, url = {https://doi.org/10.1101/2023.02.25.530025} } @article{badachhape2026-78820a75, author = {Badachhape, A. A. and Bhandari, P. and Khan, R. and Bhavane, R. and Menon, R. and Parekh, P. and Admane, P. and Ngan, E. and others}, title = {{Molecular MRI of Neuroinflammation in Alzheimer's Disease using a Folate-targeted Nanoprobe}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.27.761963}, url = {https://doi.org/10.64898/2026.10.27.761963} } @article{devlin2026-50f6f595, author = {Devlin, M. and Rodstrom, K. and Benkerdagh, C. and Ber, S. and Ramsden, N. and Rowlett, M. and Cordeiro, S. and Hayre, M. and others}, title = {{A Binding Site for CVN293 Reveals a Mechanism for Allosteric Control of THIK-1 K2P Channel Gating}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.27.761881}, url = {https://doi.org/10.64898/2026.10.27.761881} } @article{quang2026-09848cb6, author = {Quang, D. and Summers, R. and Dooling, B. R. and Esquer, H. and Zhou, Q. and LaBarbera, D. V. and Vergara, M. N. and Chial, H. J. and others}, title = {{High-content imaging of live microglia-containing Alzheimer’s disease brain organoids}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.26.761970}, url = {https://doi.org/10.64898/2026.10.26.761970} } @article{ghosh2026-549141c1, author = {Ghosh, B. and Wang, S. and Qi, C. and Ghosh, A. and Comerota, M. and Rajpurohit, C. S. and Zeldin, D. C. and Zheng, H.}, title = {{Astrocytic sEH–EET signaling regulates microglial lysosomal function and suppresses the STING–Type I interferon pathway in Alzheimer’s disease}}, journal = {bioRxiv}, year = {2026}, doi = {10.64898/2026.10.16.759679}, url = {https://doi.org/10.64898/2026.10.16.759679} } @article{juardar2026-b4b52380, author = {Juardar, P. P. and George, K. and Roy, R. K.}, title = {{Protective or Pathogenic? Microglial Responses at the Intersection of Amyloid-β, Tau, and Neuroinflammation in Alzheimer’s Disease}}, journal = {Preprints.org}, year = {2026}, doi = {10.20944/preprints202610.1771.v1}, url = {https://doi.org/10.20944/preprints202610.1771.v1} }