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% Source: https://alzhub.org/research?atag=myeloid
% 500 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{guerreiro2013-23150934,
  author  = {Guerreiro, R. and Wojtas, A. and Bras, J. and Carrasquillo, M. and Rogaeva, E. and Majounie, E. and Cruchaga, C. and Sassi, C. and others},
  title   = {{TREM2 variants in Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2013},
  doi     = {10.1056/nejmoa1211851},
  pmid    = {23150934},
  url     = {https://doi.org/10.1056/nejmoa1211851}
}

@article{sims2017-28714976,
  author  = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others},
  title   = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2017},
  doi     = {10.1038/ng.3916},
  pmid    = {28714976},
  url     = {https://doi.org/10.1038/ng.3916}
}

@article{koychev2024-39358806,
  author  = {Koychev, Ivan and Reid, Graham and Nguyen, Maggie and Mentz, Robert J and Joyce, Dan and Shah, Svati H and Holman, Rury R},
  title   = {{Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01573-x},
  pmid    = {39358806},
  url     = {https://doi.org/10.1186/s13195-024-01573-x}
}

@article{lill2015-25936935,
  author  = {Lill, C. M. and Rengmark, A. and Pihlstrøm, L. and Fogh, I. and Shatunov, A. and Sleiman, P. M. and Wang, L. S. and Liu, T. and others},
  title   = {{The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.12.009},
  pmid    = {25936935},
  url     = {https://doi.org/10.1016/j.jalz.2014.12.009}
}

@article{jonsson2013-23150908,
  author  = {Jonsson, T. and Stefansson, H. and Steinberg, S. and Jonsdottir, I. and Jonsson, P. V. and Snaedal, J. and Bjornsson, S. and Huttenlocher, J. and others},
  title   = {{Variant of TREM2 associated with the risk of Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2013},
  doi     = {10.1056/nejmoa1211103},
  pmid    = {23150908},
  url     = {https://doi.org/10.1056/nejmoa1211103}
}

@article{ruiz2014-24041969,
  author  = {Ruiz, A. and Dols-Icardo, O. and Bullido, M. J. and Pastor, P. and Rodríguez-Rodríguez, E. and López de Munain, A. and de Pancorbo, M. M. and Pérez-Tur, J. and others},
  title   = {{Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.08.011},
  pmid    = {24041969},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.08.011}
}

@article{mummery2026-41787076,
  author  = {Mummery, C. J. and Mayorga, A. J. and Simmons, A. and Chow, T. W. and Burgess, B. and Nguyen, T. and Gao, J. and Budda, B. and Park, L. Q. and Gupta, R. and Li, C. and Shi, L. and others},
  title   = {{The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial}},
  journal = {Nature Medicine},
  year    = {2026},
  doi     = {10.1038/s41591-026-04273-1},
  pmid    = {41787076},
  url     = {https://doi.org/10.1038/s41591-026-04273-1}
}

@article{morenasrodriguez2022-35305339,
  author  = {Morenas-Rodríguez, E. and Li, Y. and Nuscher, B. and Franzmeier, N. and Xiong, C. and Suárez-Calvet, M. and Fagan, A. M. and Schultz, S. and others},
  title   = {{Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study}},
  journal = {The Lancet. Neurology},
  year    = {2022},
  doi     = {10.1016/s1474-4422(22)00027-8},
  pmid    = {35305339},
  url     = {https://doi.org/10.1016/s1474-4422(22)00027-8}
}

@article{parhizkar2019-30617257,
  author  = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others},
  title   = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-018-0296-9},
  pmid    = {30617257},
  url     = {https://doi.org/10.1038/s41593-018-0296-9}
}

@article{long2024-39444037,
  author  = {Long, H. and Simmons, A. and Mayorga, A. and Burgess, B. and Nguyen, T. and Budda, B. and Rychkova, A. and Rhinn, H. and others},
  title   = {{Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01599-1},
  pmid    = {39444037},
  url     = {https://doi.org/10.1186/s13195-024-01599-1}
}

@article{rikos2024-36408688,
  author  = {Rikos, D. and Siokas, V. and Mentis, A. A. and Aloizou, A. M. and Liampas, I. and Tsouris, Z. and Peristeri, E. and Stamati, P. and others},
  title   = {{TREM2 R47H variant and risk for Alzheimer's disease: assessment in a Greek population and updated meta-analysis}},
  journal = {The International journal of neuroscience},
  year    = {2024},
  doi     = {10.1080/00207454.2022.2150844},
  pmid    = {36408688},
  url     = {https://doi.org/10.1080/00207454.2022.2150844}
}

@article{moussa2017-28086917,
  author  = {Moussa, C. and Hebron, M. and Huang, X. and Ahn, J. and Rissman, R. A. and Aisen, P. S. and Turner, R. S.},
  title   = {{Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2017},
  doi     = {10.1186/s12974-016-0779-0},
  pmid    = {28086917},
  url     = {https://doi.org/10.1186/s12974-016-0779-0}
}

@article{piccio2016-26754641,
  author  = {Piccio, L. and Deming, Y. and Del-Águila, J. L. and Ghezzi, L. and Holtzman, D. M. and Fagan, A. M. and Fenoglio, C. and Galimberti, D. and others},
  title   = {{Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-016-1533-5},
  pmid    = {26754641},
  url     = {https://doi.org/10.1007/s00401-016-1533-5}
}

@article{suarezcalvet2019-30630532,
  author  = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others},
  title   = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-018-0301-5},
  pmid    = {30630532},
  url     = {https://doi.org/10.1186/s13024-018-0301-5}
}

@article{benitez2014-24439484,
  author  = {Benitez, B. A. and Jin, S. C. and Guerreiro, R. and Graham, R. and Lord, J. and Harold, D. and Sims, R. and Lambert, J. C. and others},
  title   = {{Missense variant in TREML2 protects against Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.12.010},
  pmid    = {24439484},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.12.010}
}

@article{carrasquillo2017-27939925,
  author  = {Carrasquillo, M. M. and Allen, M. and Burgess, J. D. and Wang, X. and Strickland, S. L. and Aryal, S. and Siuda, J. and Kachadoorian, M. L. and others},
  title   = {{A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.10.005},
  pmid    = {27939925},
  url     = {https://doi.org/10.1016/j.jalz.2016.10.005}
}

@article{jin2015-25886450,
  author  = {Jin, S. C. and Carrasquillo, M. M. and Benitez, B. A. and Skorupa, T. and Carrell, D. and Patel, D. and Lincoln, S. and Krishnan, S. and others},
  title   = {{TREM2 is associated with increased risk for Alzheimer's disease in African Americans}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0016-9},
  pmid    = {25886450},
  url     = {https://doi.org/10.1186/s13024-015-0016-9}
}

@article{kleineidam2020-32166339,
  author  = {Kleineidam, L. and Chouraki, V. and Próchnicki, T. and van der Lee, S. J. and Madrid-Márquez, L. and Wagner-Thelen, H. and Karaca, I. and Weinhold, L. and others},
  title   = {{PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02138-6},
  pmid    = {32166339},
  url     = {https://doi.org/10.1007/s00401-020-02138-6}
}

@article{liu2016-26365049,
  author  = {Liu, G. and Liu, Y. and Jiang, Q. and Jiang, Y. and Feng, R. and Zhang, L. and Chen, Z. and Li, K. and others},
  title   = {{Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility}},
  journal = {Molecular neurobiology},
  year    = {2016},
  doi     = {10.1007/s12035-015-9416-7},
  pmid    = {26365049},
  url     = {https://doi.org/10.1007/s12035-015-9416-7}
}

@article{zhou2020-31932797,
  author  = {Zhou, Y. and Song, W. M. and Andhey, P. S. and Swain, A. and Levy, T. and Miller, K. R. and Poliani, P. L. and Cominelli, M. and others},
  title   = {{Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2020},
  doi     = {10.1038/s41591-019-0695-9},
  pmid    = {31932797},
  url     = {https://doi.org/10.1038/s41591-019-0695-9}
}

@article{swardfager2010-20692646,
  author  = {Swardfager, W. and Lanctôt, K. and Rothenburg, L. and Wong, A. and Cappell, J. and Herrmann, N.},
  title   = {{A meta-analysis of cytokines in Alzheimer's disease}},
  journal = {Biological psychiatry},
  year    = {2010},
  doi     = {10.1016/j.biopsych.2010.06.012},
  pmid    = {20692646},
  url     = {https://doi.org/10.1016/j.biopsych.2010.06.012}
}

@article{podlesnydrabiniok2020-33127097,
  author  = {Podleśny-Drabiniok, A. and Marcora, E. and Goate, A. M.},
  title   = {{Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics}},
  journal = {Trends in neurosciences},
  year    = {2020},
  doi     = {10.1016/j.tins.2020.10.002},
  pmid    = {33127097},
  url     = {https://doi.org/10.1016/j.tins.2020.10.002}
}

@article{hooli2014-25186855,
  author  = {Hooli, B. V. and Parrado, A. R. and Mullin, K. and Yip, W. K. and Liu, T. and Roehr, J. T. and Qiao, D. and Jessen, F. and others},
  title   = {{The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000855},
  pmid    = {25186855},
  url     = {https://doi.org/10.1212/wnl.0000000000000855}
}

@article{cuyvers2014-24119542,
  author  = {Cuyvers, E. and Bettens, K. and Philtjens, S. and Van Langenhove, T. and Gijselinck, I. and van der Zee, J. and Engelborghs, S. and Vandenbulcke, M. and others},
  title   = {{Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.09.009},
  pmid    = {24119542},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.09.009}
}

@article{krasemann2017-28930663,
  author  = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others},
  title   = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}},
  journal = {Immunity},
  year    = {2017},
  doi     = {10.1016/j.immuni.2017.08.008},
  pmid    = {28930663},
  url     = {https://doi.org/10.1016/j.immuni.2017.08.008}
}

@article{liu2018-30171911,
  author  = {Liu, D. and Cao, B. and Zhao, Y. and Huang, H. and McIntyre, R. S. and Rosenblat, J. D. and Zhou, H.},
  title   = {{Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis}},
  journal = {Neuroscience letters},
  year    = {2018},
  doi     = {10.1016/j.neulet.2018.08.038},
  pmid    = {30171911},
  url     = {https://doi.org/10.1016/j.neulet.2018.08.038}
}

@article{zhou2019-30883352,
  author  = {Zhou, S. L. and Tan, C. C. and Hou, X. H. and Cao, X. P. and Tan, L. and Yu, J. T.},
  title   = {{TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-181038},
  pmid    = {30883352},
  url     = {https://doi.org/10.3233/jad-181038}
}

@article{rayaprolu2013-23800361,
  author  = {Rayaprolu, S. and Mullen, B. and Baker, M. and Lynch, T. and Finger, E. and Seeley, W. W. and Hatanpaa, K. J. and Lomen-Hoerth, C. and others},
  title   = {{TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2013},
  doi     = {10.1186/1750-1326-8-19},
  pmid    = {23800361},
  url     = {https://doi.org/10.1186/1750-1326-8-19}
}

@article{wang2015-25728668,
  author  = {Wang, Y. and Cella, M. and Mallinson, K. and Ulrich, J. D. and Young, K. L. and Robinette, M. L. and Gilfillan, S. and Krishnan, G. M. and others},
  title   = {{TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model}},
  journal = {Cell},
  year    = {2015},
  doi     = {10.1016/j.cell.2015.01.049},
  pmid    = {25728668},
  url     = {https://doi.org/10.1016/j.cell.2015.01.049}
}

@article{franzmeier2020-33032659,
  author  = {Franzmeier, N. and Suárez-Calvet, M. and Frontzkowski, L. and Moore, A. and Hohman, T. J. and Morenas-Rodriguez, E. and Nuscher, B. and Shaw, L. and others},
  title   = {{Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00407-2},
  pmid    = {33032659},
  url     = {https://doi.org/10.1186/s13024-020-00407-2}
}

@article{jaitin2019-31257031,
  author  = {Jaitin, D. A. and Adlung, L. and Thaiss, C. A. and Weiner, A. and Li, B. and Descamps, H. and Lundgren, P. and Bleriot, C. and others},
  title   = {{Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner}},
  journal = {Cell},
  year    = {2019},
  doi     = {10.1016/j.cell.2019.05.054},
  pmid    = {31257031},
  url     = {https://doi.org/10.1016/j.cell.2019.05.054}
}

@article{wang2020-32579671,
  author  = {Wang, S. and Mustafa, M. and Yuede, C. M. and Salazar, S. V. and Kong, P. and Long, H. and Ward, M. and Siddiqui, O. and others},
  title   = {{Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model}},
  journal = {The Journal of experimental medicine},
  year    = {2020},
  doi     = {10.1084/jem.20200785},
  pmid    = {32579671},
  url     = {https://doi.org/10.1084/jem.20200785}
}

@article{dalmasso2019-30705288,
  author  = {Dalmasso, M. C. and Brusco, L. I. and Olivar, N. and Muchnik, C. and Hanses, C. and Milz, E. and Becker, J. and Heilmann-Heimbach, S. and others},
  title   = {{Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease}},
  journal = {Translational psychiatry},
  year    = {2019},
  doi     = {10.1038/s41398-019-0394-9},
  pmid    = {30705288},
  url     = {https://doi.org/10.1038/s41398-019-0394-9}
}

@article{chan2015-26414614,
  author  = {Chan, G. and White, C. C. and Winn, P. A. and Cimpean, M. and Replogle, J. M. and Glick, L. R. and Cuerdon, N. E. and Ryan, K. J. and others},
  title   = {{CD33 modulates TREM2: convergence of Alzheimer loci}},
  journal = {Nature neuroscience},
  year    = {2015},
  doi     = {10.1038/nn.4126},
  pmid    = {26414614},
  url     = {https://doi.org/10.1038/nn.4126}
}

@article{wang2016-27091843,
  author  = {Wang, Y. and Ulland, T. K. and Ulrich, J. D. and Song, W. and Tzaferis, J. A. and Hole, J. T. and Yuan, P. and Mahan, T. E. and others},
  title   = {{TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques}},
  journal = {The Journal of experimental medicine},
  year    = {2016},
  doi     = {10.1084/jem.20151948},
  pmid    = {27091843},
  url     = {https://doi.org/10.1084/jem.20151948}
}

@article{suarezcalvet2016-26941262,
  author  = {Suárez-Calvet, M. and Kleinberger, G. and MÁ, Araque Caballero and Brendel, M. and Rominger, A. and Alcolea, D. and Fortea, J. and Lleó, A. and others},
  title   = {{sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201506123},
  pmid    = {26941262},
  url     = {https://doi.org/10.15252/emmm.201506123}
}

@article{heslegrave2016-26754172,
  author  = {Heslegrave, A. and Heywood, W. and Paterson, R. and Magdalinou, N. and Svensson, J. and Johansson, P. and Öhrfelt, A. and Blennow, K. and others},
  title   = {{Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0071-x},
  pmid    = {26754172},
  url     = {https://doi.org/10.1186/s13024-016-0071-x}
}

@article{baughn2023-36927019,
  author  = {Baughn, M. W. and Melamed, Z. and López-Erauskin, J. and Beccari, M. S. and Ling, K. and Zuberi, A. and Presa, M. and Gonzalo-Gil, E. and others},
  title   = {{Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies}},
  journal = {Science (New York, N.Y.)},
  year    = {2023},
  doi     = {10.1126/science.abq5622},
  pmid    = {36927019},
  url     = {https://doi.org/10.1126/science.abq5622}
}

@article{potter2021-33778150,
  author  = {Potter, H. and Woodcock, J. H. and Boyd, T. D. and Coughlan, C. M. and O'Shaughnessy, JR. and Borges, M. T. and Thaker, A. A. and Raj, B. A. and others},
  title   = {{Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12158},
  pmid    = {33778150},
  url     = {https://doi.org/10.1002/trc2.12158}
}

@article{fan2017-28122877,
  author  = {Fan, Z. and Brooks, D. J. and Okello, A. and Edison, P.},
  title   = {{An early and late peak in microglial activation in Alzheimer's disease trajectory}},
  journal = {Brain : a journal of neurology},
  year    = {2017},
  doi     = {10.1093/brain/aww349},
  pmid    = {28122877},
  url     = {https://doi.org/10.1093/brain/aww349}
}

@article{ulland2017-28802038,
  author  = {Ulland, T. K. and Song, W. M. and Huang, S. C. and Ulrich, J. D. and Sergushichev, A. and Beatty, W. L. and Loboda, A. A. and Zhou, Y. and others},
  title   = {{TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease}},
  journal = {Cell},
  year    = {2017},
  doi     = {10.1016/j.cell.2017.07.023},
  pmid    = {28802038},
  url     = {https://doi.org/10.1016/j.cell.2017.07.023}
}

@article{leyns2019-31235932,
  author  = {Leyns, C. E. G. and Gratuze, M. and Narasimhan, S. and Jain, N. and Koscal, L. J. and Jiang, H. and Manis, M. and Colonna, M. and others},
  title   = {{TREM2 function impedes tau seeding in neuritic plaques}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0433-0},
  pmid    = {31235932},
  url     = {https://doi.org/10.1038/s41593-019-0433-0}
}

@article{wilson2020-32065223,
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  title   = {{Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awaa021},
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@article{wang2024-38172904,
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  title   = {{Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease}},
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  year    = {2024},
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@article{martinsferreira2025-39820004,
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  title   = {{The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions}},
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  year    = {2025},
  doi     = {10.1038/s41467-025-56124-1},
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@article{ramanan2015-26268530,
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  year    = {2015},
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  title   = {{TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis}},
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@article{molgora2020-32783918,
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  title   = {{TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy}},
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  title   = {{TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models}},
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  year    = {2015},
  doi     = {10.1084/jem.20142322},
  pmid    = {25732305},
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@article{wang2022-36306735,
  author  = {Wang, S. and Sudan, R. and Peng, V. and Zhou, Y. and Du, S. and Yuede, C. M. and Lei, T. and Hou, J. and others},
  title   = {{TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways}},
  journal = {Cell},
  year    = {2022},
  doi     = {10.1016/j.cell.2022.09.033},
  pmid    = {36306735},
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@article{cignarella2020-32772264,
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  title   = {{TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis}},
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  year    = {2020},
  doi     = {10.1007/s00401-020-02193-z},
  pmid    = {32772264},
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  title   = {{Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement}},
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  year    = {2013},
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@article{zhao2018-29518356,
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  title   = {{TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function}},
  journal = {Neuron},
  year    = {2018},
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  pmid    = {29518356},
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@article{yuan2016-27196974,
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  title   = {{TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy}},
  journal = {Neuron},
  year    = {2016},
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@article{filipello2018-29752066,
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  title   = {{The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity}},
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  year    = {2018},
  doi     = {10.1016/j.immuni.2018.04.016},
  pmid    = {29752066},
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@article{zhong2019-30911003,
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  title   = {{Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model}},
  journal = {Nature communications},
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  pmid    = {30911003},
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@article{borroni2014-24139279,
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  title   = {{Heterozygous TREM2 mutations in frontotemporal dementia}},
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@article{smith2016-27522519,
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  title   = {{Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain}},
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@article{biel2023-36620941,
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  title   = {{sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease}},
  journal = {EMBO molecular medicine},
  year    = {2023},
  doi     = {10.15252/emmm.202216987},
  pmid    = {36620941},
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@article{woollacott2018-30111356,
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  title   = {{Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup}},
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  year    = {2018},
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  pmid    = {30111356},
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@article{wang2024-38841103,
  author  = {Wang, R. and Zhan, Y. and Zhu, W. and Yang, Q. and Pei, J.},
  title   = {{Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2024},
  doi     = {10.3389/fnagi.2024.1407980},
  pmid    = {38841103},
  url     = {https://doi.org/10.3389/fnagi.2024.1407980}
}

@article{amin2022-35314318,
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  title   = {{Inflammation in dementia with Lewy bodies}},
  journal = {Neurobiology of disease},
  year    = {2022},
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  pmid    = {35314318},
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@article{nguyen2020-32840654,
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  title   = {{APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease}},
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  year    = {2020},
  doi     = {10.1007/s00401-020-02200-3},
  pmid    = {32840654},
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@article{mazaheri2017-28483841,
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  title   = {{TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury}},
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  year    = {2017},
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  pmid    = {28483841},
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@article{cady2014-24535663,
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  title   = {{TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.6237},
  pmid    = {24535663},
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@article{leyns2017-29073081,
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  title   = {{TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy}},
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  year    = {2017},
  doi     = {10.1073/pnas.1710311114},
  pmid    = {29073081},
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@article{griciuc2019-31301936,
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  title   = {{TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2019},
  doi     = {10.1016/j.neuron.2019.06.010},
  pmid    = {31301936},
  url     = {https://doi.org/10.1016/j.neuron.2019.06.010}
}

@article{mcquade2020-33097708,
  author  = {McQuade, A. and Kang, Y. J. and Hasselmann, J. and Jairaman, A. and Sotelo, A. and Coburn, M. and Shabestari, S. K. and Chadarevian, J. P. and others},
  title   = {{Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-19227-5},
  pmid    = {33097708},
  url     = {https://doi.org/10.1038/s41467-020-19227-5}
}

@article{bozaserrano2019-31006066,
  author  = {Boza-Serrano, A. and Ruiz, R. and Sanchez-Varo, R. and García-Revilla, J. and Yang, Y. and Jimenez-Ferrer, I. and Paulus, A. and Wennström, M. and others},
  title   = {{Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02013-z},
  pmid    = {31006066},
  url     = {https://doi.org/10.1007/s00401-019-02013-z}
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@article{song2018-29321225,
  author  = {Song, W. M. and Joshita, S. and Zhou, Y. and Ulland, T. K. and Gilfillan, S. and Colonna, M.},
  title   = {{Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism}},
  journal = {The Journal of experimental medicine},
  year    = {2018},
  doi     = {10.1084/jem.20171529},
  pmid    = {29321225},
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@article{hou2021-33586673,
  author  = {Hou, J. and Zhang, J. and Cui, P. and Zhou, Y. and Liu, C. and Wu, X. and Ji, Y. and Wang, S. and others},
  title   = {{TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis}},
  journal = {The Journal of clinical investigation},
  year    = {2021},
  doi     = {10.1172/jci135197},
  pmid    = {33586673},
  url     = {https://doi.org/10.1172/jci135197}
}

@article{slattery2014-25160042,
  author  = {Slattery, C. F. and Beck, J. A. and Harper, L. and Adamson, G. and Abdi, Z. and Uphill, J. and Campbell, T. and Druyeh, R. and others},
  title   = {{R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia}},
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  year    = {2014},
  doi     = {10.1016/j.jalz.2014.05.1751},
  pmid    = {25160042},
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@article{indirachandran2023-35712786,
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  title   = {{Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness}},
  journal = {Hepatology (Baltimore, Md.)},
  year    = {2023},
  doi     = {10.1002/hep.32620},
  pmid    = {35712786},
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@article{korvatska2015-26076170,
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  title   = {{R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2015.0979},
  pmid    = {26076170},
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@article{yeh2016-27477018,
  author  = {Yeh, F. L. and Wang, Y. and Tom, I. and Gonzalez, L. C. and Sheng, M.},
  title   = {{TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia}},
  journal = {Neuron},
  year    = {2016},
  doi     = {10.1016/j.neuron.2016.06.015},
  pmid    = {27477018},
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@article{deczkowska2020-32531244,
  author  = {Deczkowska, A. and Weiner, A. and Amit, I.},
  title   = {{The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway}},
  journal = {Cell},
  year    = {2020},
  doi     = {10.1016/j.cell.2020.05.003},
  pmid    = {32531244},
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@article{jay2017-28100745,
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  title   = {{Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2110-16.2016},
  pmid    = {28100745},
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@article{vanlengerich2023-36635496,
  author  = {van Lengerich, B. and Zhan, L. and Xia, D. and Chan, D. and Joy, D. and Park, J. I. and Tatarakis, D. and Calvert, M. and others},
  title   = {{A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models}},
  journal = {Nature neuroscience},
  year    = {2023},
  doi     = {10.1038/s41593-022-01240-0},
  pmid    = {36635496},
  url     = {https://doi.org/10.1038/s41593-022-01240-0}
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@article{park2023-37081148,
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  title   = {{TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-023-01475-4},
  pmid    = {37081148},
  url     = {https://doi.org/10.1038/s41590-023-01475-4}
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@article{song2017-27520774,
  author  = {Song, W. and Hooli, B. and Mullin, K. and Jin, S. C. and Cella, M. and Ulland, T. K. and Wang, Y. and Tanzi, R. E. and others},
  title   = {{Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.07.004},
  pmid    = {27520774},
  url     = {https://doi.org/10.1016/j.jalz.2016.07.004}
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@article{gratuze2020-32544086,
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  title   = {{Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration}},
  journal = {The Journal of clinical investigation},
  year    = {2020},
  doi     = {10.1172/jci138179},
  pmid    = {32544086},
  url     = {https://doi.org/10.1172/jci138179}
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@article{xie2022-34916658,
  author  = {Xie, M. and Liu, Y. U. and Zhao, S. and Zhang, L. and Bosco, D. B. and Pang, Y. P. and Zhong, J. and Sheth, U. and others},
  title   = {{TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration}},
  journal = {Nature neuroscience},
  year    = {2022},
  doi     = {10.1038/s41593-021-00975-6},
  pmid    = {34916658},
  url     = {https://doi.org/10.1038/s41593-021-00975-6}
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@article{jain2023-36219197,
  author  = {Jain, N. and Lewis, C. A. and Ulrich, J. D. and Holtzman, D. M.},
  title   = {{Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading}},
  journal = {The Journal of experimental medicine},
  year    = {2023},
  doi     = {10.1084/jem.20220654},
  pmid    = {36219197},
  url     = {https://doi.org/10.1084/jem.20220654}
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@article{ruedacarrasco2023-37575021,
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  title   = {{Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models}},
  journal = {The EMBO journal},
  year    = {2023},
  doi     = {10.15252/embj.2022113246},
  pmid    = {37575021},
  url     = {https://doi.org/10.15252/embj.2022113246}
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@article{huang2015-25852195,
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  title   = {{Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis}},
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  year    = {2015},
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  pmid    = {25852195},
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@article{ulland2018-30266932,
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@article{gratuze2018-30572908,
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  title   = {{New insights into the role of TREM2 in Alzheimer's disease}},
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  year    = {2018},
  doi     = {10.1186/s13024-018-0298-9},
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@article{zhong2017-28209725,
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@article{ulrich2017-28426958,
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@article{schlepckow2020-32154671,
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  title   = {{Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region}},
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@article{jung2022-35933399,
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  title   = {{Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts}},
  journal = {Nature communications},
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@article{gouna2021-34424266,
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  title   = {{TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination}},
  journal = {The Journal of experimental medicine},
  year    = {2021},
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@article{rachmian2024-38637622,
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  title   = {{Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain}},
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  title   = {{Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease}},
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@article{ganguly2024-39172787,
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  title   = {{Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2}},
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@article{schlepckow2023-37863592,
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  title   = {{Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease}},
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@article{tagliatti2024-38159572,
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  title   = {{Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development}},
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@article{cui2025-39971937,
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  title   = {{TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity}},
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@article{ewers2019-31462511,
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  title   = {{TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers}},
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@article{nugent2020-31902528,
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  title   = {{TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge}},
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  pmid    = {31902528},
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@article{katzenelenbogen2020-32783915,
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  title   = {{Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer}},
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@article{jay2017-28768545,
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  year    = {2017},
  doi     = {10.1186/s13024-017-0197-5},
  pmid    = {28768545},
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@article{lee2018-29518357,
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  title   = {{Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models}},
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  year    = {2018},
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  pmid    = {29518357},
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@article{chen2020-32466767,
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  title   = {{TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice}},
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  year    = {2020},
  doi     = {10.1186/s12974-020-01853-x},
  pmid    = {32466767},
  url     = {https://doi.org/10.1186/s12974-020-01853-x}
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@article{cantoni2015-25631124,
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  title   = {{TREM2 regulates microglial cell activation in response to demyelination in vivo}},
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  year    = {2015},
  doi     = {10.1007/s00401-015-1388-1},
  pmid    = {25631124},
  url     = {https://doi.org/10.1007/s00401-015-1388-1}
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@article{wang2023-36521495,
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  title   = {{Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development}},
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  year    = {2023},
  doi     = {10.1016/j.immuni.2022.11.013},
  pmid    = {36521495},
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@article{carmona2018-30033062,
  author  = {Carmona, S. and Zahs, K. and Wu, E. and Dakin, K. and Bras, J. and Guerreiro, R.},
  title   = {{The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders}},
  journal = {The Lancet. Neurology},
  year    = {2018},
  doi     = {10.1016/s1474-4422(18)30232-1},
  pmid    = {30033062},
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@article{chenghathaway2018-29859094,
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  title   = {{The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0262-8},
  pmid    = {29859094},
  url     = {https://doi.org/10.1186/s13024-018-0262-8}
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@article{kleinberger2017-28559417,
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  title   = {{The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism}},
  journal = {The EMBO journal},
  year    = {2017},
  doi     = {10.15252/embj.201796516},
  pmid    = {28559417},
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@article{sayed2018-30232263,
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  title   = {{Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy}},
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  year    = {2018},
  doi     = {10.1073/pnas.1811411115},
  pmid    = {30232263},
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@article{sayed2021-34851693,
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  title   = {{AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation}},
  journal = {Science translational medicine},
  year    = {2021},
  doi     = {10.1126/scitranslmed.abe3947},
  pmid    = {34851693},
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@article{pottier2013-23380991,
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  title   = {{TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease}},
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  year    = {2013},
  doi     = {10.3233/jad-122311},
  pmid    = {23380991},
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@article{do2022-35867799,
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  title   = {{TREM2 macrophages induced by human lipids drive inflammation in acne lesions}},
  journal = {Science immunology},
  year    = {2022},
  doi     = {10.1126/sciimmunol.abo2787},
  pmid    = {35867799},
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@article{gratuze2023-36368315,
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  title   = {{TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4}},
  journal = {Neuron},
  year    = {2023},
  doi     = {10.1016/j.neuron.2022.10.022},
  pmid    = {36368315},
  url     = {https://doi.org/10.1016/j.neuron.2022.10.022}
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@article{zhao2022-36107206,
  author  = {Zhao, N. and Qiao, W. and Li, F. and Ren, Y. and Zheng, J. and Martens, Y. A. and Wang, X. and Li, L. and others},
  title   = {{Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia}},
  journal = {The Journal of experimental medicine},
  year    = {2022},
  doi     = {10.1084/jem.20212479},
  pmid    = {36107206},
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@article{filipello2023-37115208,
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  title   = {{Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation}},
  journal = {Acta neuropathologica},
  year    = {2023},
  doi     = {10.1007/s00401-023-02568-y},
  pmid    = {37115208},
  url     = {https://doi.org/10.1007/s00401-023-02568-y}
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@article{iizasa2021-33863908,
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  title   = {{TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-22620-3},
  pmid    = {33863908},
  url     = {https://doi.org/10.1038/s41467-021-22620-3}
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@article{rauchmann2019-30458365,
  author  = {Rauchmann, B. S. and Schneider-Axmann, T. and Alexopoulos, P. and Perneczky, R. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum}},
  journal = {Neurobiology of aging},
  year    = {2019},
  doi     = {10.1016/j.neurobiolaging.2018.10.022},
  pmid    = {30458365},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2018.10.022}
}

@article{turnbull2006-16951310,
  author  = {Turnbull, Isaiah R. and Gilfillan, Susan and Cella, Marina and Aoshi, Taiki and Miller, Mark J. and Piccio, Laura M. and Hernandez, Maristela and Colonna, Marco},
  title   = {{Cutting Edge: TREM-2 Attenuates Macrophage Activation}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.6.3520},
  pmid    = {16951310},
  url     = {https://doi.org/10.4049/jimmunol.177.6.3520}
}

@article{jiang2016-27501831,
  author  = {Jiang, T. and Hou, J. K. and Gao, Q. and Yu, J. T. and Zhou, J. S. and Zhao, H. D. and Zhang, Y. D.},
  title   = {{TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects}},
  journal = {Current neurovascular research},
  year    = {2016},
  doi     = {10.2174/1567202613666160808095530},
  pmid    = {27501831},
  url     = {https://doi.org/10.2174/1567202613666160808095530}
}

@article{hamerman2006-16887962,
  author  = {Hamerman, Jessica A. and Jarjoura, Jessica R and Humphrey, Mary Beth and Nakamura, Mary C. and Seaman, William E. and Lanier, Lewis L.},
  title   = {{Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.4.2051},
  pmid    = {16887962},
  url     = {https://doi.org/10.4049/jimmunol.177.4.2051}
}

@article{piccio2008-18790823,
  author  = {Piccio, Laura M. and Buonsanti, Cecilia and Cella, Marina and Tassi, Ilaria and Schmidt, Robert E. and Fenoglio, Chiara and Rinker, John Robert and Naismith, Robert T. and Panina‐Bordignon, Paola and Passini, Nadia and Galimberti, Daniela and Scarpini, Elio Angelo and Colonna, Marco and Cross, Anne Haney},
  title   = {{Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation}},
  journal = {Brain},
  year    = {2008},
  doi     = {10.1093/brain/awn217},
  pmid    = {18790823},
  url     = {https://doi.org/10.1093/brain/awn217}
}

@article{hsieh2009-19302484,
  author  = {Hsieh, C. L. and Koike, M. and Spusta, S. C. and Niemi, E. C. and Yenari, M. and Nakamura, M. C. and Seaman, W. E.},
  title   = {{A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06042.x},
  pmid    = {19302484},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.06042.x}
}

@article{takahashi2007-17425404,
  author  = {Takahashi, K. and Prinz, M. and Stagi, M. and Chechneva, O. and Neumann, H.},
  title   = {{TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis}},
  journal = {PLoS medicine},
  year    = {2007},
  doi     = {10.1371/journal.pmed.0040124},
  pmid    = {17425404},
  url     = {https://doi.org/10.1371/journal.pmed.0040124}
}

@article{kawabori2015-25716838,
  author  = {Kawabori, M. and Kacimi, R. and Kauppinen, T. and Calosing, C. and Kim, J. Y. and Hsieh, C. L. and Nakamura, M. C. and Yenari, M. A.},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.2620-14.2015},
  pmid    = {25716838},
  url     = {https://doi.org/10.1523/jneurosci.2620-14.2015}
}

@article{binnewies2021-34686340,
  author  = {Binnewies, M. and Pollack, J. L. and Rudolph, J. and Dash, S. and Abushawish, M. and Lee, T. and Jahchan, N. S. and Canaday, P. and others},
  title   = {{Targeting TREM2 on tumor-associated macrophages enhances immunotherapy}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.109844},
  pmid    = {34686340},
  url     = {https://doi.org/10.1016/j.celrep.2021.109844}
}

@article{zheng2017-28077724,
  author  = {Zheng, H. and Jia, L. and Liu, C. C. and Rong, Z. and Zhong, L. and Yang, L. and Chen, X. F. and Fryer, J. D. and others},
  title   = {{TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2459-16.2017},
  pmid    = {28077724},
  url     = {https://doi.org/10.1523/jneurosci.2459-16.2017}
}

@article{ulrich2014-24893973,
  author  = {Ulrich, J. D. and Finn, M. B. and Wang, Y. and Shen, A. and Mahan, T. E. and Jiang, H. and Stewart, F. R. and Piccio, L. and others},
  title   = {{Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2014},
  doi     = {10.1186/1750-1326-9-20},
  pmid    = {24893973},
  url     = {https://doi.org/10.1186/1750-1326-9-20}
}

@article{paloneva2003-12925681,
  author  = {Paloneva, J. and Mandelin, J. and Kiialainen, A. and Bohling, T. and Prudlo, J. and Hakola, P. and Haltia, M. and Konttinen, Y. T. and others},
  title   = {{DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features}},
  journal = {The Journal of experimental medicine},
  year    = {2003},
  doi     = {10.1084/jem.20030027},
  pmid    = {12925681},
  url     = {https://doi.org/10.1084/jem.20030027}
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@article{bemiller2017-29037207,
  author  = {Bemiller, S. M. and McCray, T. J. and Allan, K. and Formica, S. V. and Xu, G. and Wilson, G. and Kokiko-Cochran, O. N. and Crish, S. D. and others},
  title   = {{TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0216-6},
  pmid    = {29037207},
  url     = {https://doi.org/10.1186/s13024-017-0216-6}
}

@article{hou2022-36564824,
  author  = {Hou, J. and Chen, Y. and Grajales-Reyes, G. and Colonna, M.},
  title   = {{TREM2 dependent and independent functions of microglia in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00588-y},
  pmid    = {36564824},
  url     = {https://doi.org/10.1186/s13024-022-00588-y}
}

@article{xiong2020-33033253,
  author  = {Xiong, D. and Wang, Y. and You, M.},
  title   = {{A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-18546-x},
  pmid    = {33033253},
  url     = {https://doi.org/10.1038/s41467-020-18546-x}
}

@article{zhao2022-36070367,
  author  = {Zhao, P. and Xu, Y. and Jiang, L. and Fan, X. and Li, L. and Li, X. and Arase, H. and Zhao, Y. and others},
  title   = {{A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease}},
  journal = {Science translational medicine},
  year    = {2022},
  doi     = {10.1126/scitranslmed.abq0095},
  pmid    = {36070367},
  url     = {https://doi.org/10.1126/scitranslmed.abq0095}
}

@article{ellwanger2021-33446504,
  author  = {Ellwanger, D. C. and Wang, S. and Brioschi, S. and Shao, Z. and Green, L. and Case, R. and Yoo, D. and Weishuhn, D. and others},
  title   = {{Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2017742118},
  pmid    = {33446504},
  url     = {https://doi.org/10.1073/pnas.2017742118}
}

@article{zhang2023-37865646,
  author  = {Zhang, X. and Tang, L. and Yang, J. and Meng, L. and Chen, J. and Zhou, L. and Wang, J. and Xiong, M. and others},
  title   = {{Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-42505-x},
  pmid    = {37865646},
  url     = {https://doi.org/10.1038/s41467-023-42505-x}
}

@article{zhao2022-36519540,
  author  = {Zhao, A. and Jiao, Y. and Ye, G. and Kang, W. and Tan, L. and Li, Y. and Deng, Y. and Liu, J. and others},
  title   = {{Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease}},
  journal = {The Journal of clinical investigation},
  year    = {2022},
  doi     = {10.1172/jci158708},
  pmid    = {36519540},
  url     = {https://doi.org/10.1172/jci158708}
}

@article{schindler2021-33884297,
  author  = {Schindler, S. E. and Cruchaga, C. and Joseph, A. and McCue, L. and Farias, F. H. G. and Wilkins, C. H. and Deming, Y. and Henson, R. L. and others},
  title   = {{African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants}},
  journal = {Neurology. Genetics},
  year    = {2021},
  doi     = {10.1212/nxg.0000000000000571},
  pmid    = {33884297},
  url     = {https://doi.org/10.1212/nxg.0000000000000571}
}

@article{xiang2018-30185230,
  author  = {Xiang, X. and Piers, T. M. and Wefers, B. and Zhu, K. and Mallach, A. and Brunner, B. and Kleinberger, G. and Song, W. and others},
  title   = {{The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0280-6},
  pmid    = {30185230},
  url     = {https://doi.org/10.1186/s13024-018-0280-6}
}

@article{jiang2014-25047746,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhang, Q. Q. and Cao, L. and Tan, M. S. and Gu, L. Z. and Wang, H. F. and others},
  title   = {{Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2014},
  doi     = {10.1038/npp.2014.164},
  pmid    = {25047746},
  url     = {https://doi.org/10.1038/npp.2014.164}
}

@article{lee2021-33675684,
  author  = {Lee, S. H. and Meilandt, W. J. and Xie, L. and Gandham, V. D. and Ngu, H. and Barck, K. H. and Rezzonico, M. G. and Imperio, J. and others},
  title   = {{Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2021.02.010},
  pmid    = {33675684},
  url     = {https://doi.org/10.1016/j.neuron.2021.02.010}
}

@article{kober2016-27995897,
  author  = {Kober, D. L. and Alexander-Brett, J. M. and Karch, C. M. and Cruchaga, C. and Colonna, M. and Holtzman, M. J. and Brett, T. J.},
  title   = {{Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms}},
  journal = {eLife},
  year    = {2016},
  doi     = {10.7554/elife.20391},
  pmid    = {27995897},
  url     = {https://doi.org/10.7554/elife.20391}
}

@article{frank2008-18551625,
  author  = {Frank, S. and Burbach, G. J. and Bonin, M. and Walter, M. and Streit, W. and Bechmann, I. and Deller, T.},
  title   = {{TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice}},
  journal = {Glia},
  year    = {2008},
  doi     = {10.1002/glia.20710},
  pmid    = {18551625},
  url     = {https://doi.org/10.1002/glia.20710}
}

@article{hendrikx2022-35750138,
  author  = {Hendrikx, T. and Porsch, F. and Kiss, M. G. and Rajcic, D. and Papac-Miličević, N. and Hoebinger, C. and Goederle, L. and Hladik, A. and others},
  title   = {{Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH}},
  journal = {Journal of hepatology},
  year    = {2022},
  doi     = {10.1016/j.jhep.2022.06.004},
  pmid    = {35750138},
  url     = {https://doi.org/10.1016/j.jhep.2022.06.004}
}

@article{liu2020-32959884,
  author  = {Liu, W. and Taso, O. and Wang, R. and Bayram, S. and Graham, A. C. and Garcia-Reitboeck, P. and Mallach, A. and Andrews, W. D. and others},
  title   = {{Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions}},
  journal = {Human molecular genetics},
  year    = {2020},
  doi     = {10.1093/hmg/ddaa209},
  pmid    = {32959884},
  url     = {https://doi.org/10.1093/hmg/ddaa209}
}

@article{li2022-35658903,
  author  = {Li, R. Y. and Qin, Q. and Yang, H. C. and Wang, Y. Y. and Mi, Y. X. and Yin, Y. S. and Wang, M. and Yu, C. J. and others},
  title   = {{TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00542-y},
  pmid    = {35658903},
  url     = {https://doi.org/10.1186/s13024-022-00542-y}
}

@article{zhong2018-29587871,
  author  = {Zhong, L. and Wang, Z. and Wang, D. and Martens, Y. A. and Wu, L. and Xu, Y. and Wang, K. and others},
  title   = {{Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0247-7},
  pmid    = {29587871},
  url     = {https://doi.org/10.1186/s13024-018-0247-7}
}

@article{wang2019-30930146,
  author  = {Wang, E. C. E. and Dai, Z. and Ferrante, A. W. and Drake, C. G. and Christiano, A. M.},
  title   = {{A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth}},
  journal = {Cell stem cell},
  year    = {2019},
  doi     = {10.1016/j.stem.2019.01.011},
  pmid    = {30930146},
  url     = {https://doi.org/10.1016/j.stem.2019.01.011}
}

@article{forabosco2013-23855984,
  author  = {Forabosco, P. and Ramasamy, A. and Trabzuni, D. and Walker, R. and Smith, C. and Bras, J. and Levine, A. P. and Hardy, J. and others},
  title   = {{Insights into TREM2 biology by network analysis of human brain gene expression data}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.05.001},
  pmid    = {23855984},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.05.001}
}

@article{zhong2023-37442133,
  author  = {Zhong, L. and Sheng, X. and Wang, W. and Li, Y. and Zhuo, R. and Wang, K. and Zhang, L. and Hu, D. D. and others},
  title   = {{TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration}},
  journal = {Immunity},
  year    = {2023},
  doi     = {10.1016/j.immuni.2023.06.016},
  pmid    = {37442133},
  url     = {https://doi.org/10.1016/j.immuni.2023.06.016}
}

@article{price2020-32795308,
  author  = {Price, B. R. and Sudduth, T. L. and Weekman, E. M. and Johnson, S. and Hawthorne, D. and Woolums, A. and Wilcock, D. M.},
  title   = {{Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01915-0},
  pmid    = {32795308},
  url     = {https://doi.org/10.1186/s12974-020-01915-0}
}

@article{filipello2022-35041990,
  author  = {Filipello, F. and Goldsbury, C. and You, S. F. and Locca, A. and Karch, C. M. and Piccio, L.},
  title   = {{Soluble TREM2: Innocent bystander or active player in neurological diseases?}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105630},
  pmid    = {35041990},
  url     = {https://doi.org/10.1016/j.nbd.2022.105630}
}

@article{sun2023-37172094,
  author  = {Sun, R. and Han, R. and McCornack, C. and Khan, S. and Tabor, G. T. and Chen, Y. and Hou, J. and Jiang, H. and others},
  title   = {{TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma}},
  journal = {Science advances},
  year    = {2023},
  doi     = {10.1126/sciadv.ade3559},
  pmid    = {37172094},
  url     = {https://doi.org/10.1126/sciadv.ade3559}
}

@article{gotzl2019-31122931,
  author  = {Götzl, J. K. and Brendel, M. and Werner, G. and Parhizkar, S. and Sebastian Monasor, L. and Kleinberger, G. and Colombo, A. V. and Deussing, M. and others},
  title   = {{Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism}},
  journal = {EMBO molecular medicine},
  year    = {2019},
  doi     = {10.15252/emmm.201809711},
  pmid    = {31122931},
  url     = {https://doi.org/10.15252/emmm.201809711}
}

@article{hauremirande2017-28612290,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Fanutza, T. and Kim, S. H. and Klein, W. L. and Glabe, C. and Readhead, B. and Dudley, J. T. and others},
  title   = {{Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology}},
  journal = {Acta neuropathologica},
  year    = {2017},
  doi     = {10.1007/s00401-017-1737-3},
  pmid    = {28612290},
  url     = {https://doi.org/10.1007/s00401-017-1737-3}
}

@article{gong2024-38182899,
  author  = {Gong, S. and Zhai, M. and Shi, J. and Yu, G. and Lei, Z. and Shi, Y. and Zeng, Y. and Ju, P. and others},
  title   = {{TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53}},
  journal = {Cell death and differentiation},
  year    = {2024},
  doi     = {10.1038/s41418-023-01252-8},
  pmid    = {38182899},
  url     = {https://doi.org/10.1038/s41418-023-01252-8}
}

@article{parhizkar2023-37099634,
  author  = {Parhizkar, S. and Gent, G. and Chen, Y. and Rensing, N. and Gratuze, M. and Strout, G. and Sviben, S. and Tycksen, E. and others},
  title   = {{Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice}},
  journal = {Science translational medicine},
  year    = {2023},
  doi     = {10.1126/scitranslmed.ade6285},
  pmid    = {37099634},
  url     = {https://doi.org/10.1126/scitranslmed.ade6285}
}

@article{gispert2016-27423963,
  author  = {Gispert, J. D. and Suárez-Calvet, M. and Monté, G. C. and Tucholka, A. and Falcon, C. and Rojas, S. and Rami, L. and Sánchez-Valle, R. and others},
  title   = {{Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.06.005},
  pmid    = {27423963},
  url     = {https://doi.org/10.1016/j.jalz.2016.06.005}
}

@article{yoo2023-37541210,
  author  = {Yoo, Y. and Neumayer, G. and Shibuya, Y. and Mader, M. M. and Wernig, M.},
  title   = {{A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease}},
  journal = {Cell stem cell},
  year    = {2023},
  doi     = {10.1016/j.stem.2023.07.006},
  pmid    = {37541210},
  url     = {https://doi.org/10.1016/j.stem.2023.07.006}
}

@article{reifschneider2022-35019161,
  author  = {Reifschneider, A. and Robinson, S. and van Lengerich, B. and Gnörich, J. and Logan, T. and Heindl, S. and Vogt, M. A. and Weidinger, E. and others},
  title   = {{Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency}},
  journal = {The EMBO journal},
  year    = {2022},
  doi     = {10.15252/embj.2021109108},
  pmid    = {35019161},
  url     = {https://doi.org/10.15252/embj.2021109108}
}

@article{leber2014-24910390,
  author  = {Le Ber, I. and De Septenville, A. and Guerreiro, R. and Bras, J. and Camuzat, A. and Caroppo, P. and Lattante, S. and Couarch, P. and others},
  title   = {{Homozygous TREM2 mutation in a family with atypical frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.04.010},
  pmid    = {24910390},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.04.010}
}

@article{vilalta2021-33823153,
  author  = {Vilalta, A. and Zhou, Y. and Sevalle, J. and Griffin, J. K. and Satoh, K. and Allendorf, D. H. and De, S. and Puigdellívol, M. and others},
  title   = {{Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation}},
  journal = {The Journal of biological chemistry},
  year    = {2021},
  doi     = {10.1016/j.jbc.2021.100631},
  pmid    = {33823153},
  url     = {https://doi.org/10.1016/j.jbc.2021.100631}
}

@article{gisslen2019-30568991,
  author  = {Gisslén, M. and Heslegrave, A. and Veleva, E. and Yilmaz, A. and Andersson, L. M. and Hagberg, L. and Spudich, S. and Fuchs, D. and others},
  title   = {{CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection}},
  journal = {Neurology(R) neuroimmunology \& neuroinflammation},
  year    = {2019},
  doi     = {10.1212/nxi.0000000000000512},
  pmid    = {30568991},
  url     = {https://doi.org/10.1212/nxi.0000000000000512}
}

@article{zhang2025-40247363,
  author  = {Zhang, L. and Xiang, X. and Li, Y. and Bu, G. and Chen, X. F.},
  title   = {{TREM2 and sTREM2 in Alzheimer's disease: from mechanisms to therapies}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00834-z},
  pmid    = {40247363},
  url     = {https://doi.org/10.1186/s13024-025-00834-z}
}

@article{yu2024-38289348,
  author  = {Yu, C. and Lad, E. M. and Mathew, R. and Shiraki, N. and Littleton, S. and Chen, Y. and Hou, J. and Schlepckow, K. and others},
  title   = {{Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231011},
  pmid    = {38289348},
  url     = {https://doi.org/10.1084/jem.20231011}
}

@article{yu2014-24184202,
  author  = {Yu, J. T. and Jiang, T. and Wang, Y. L. and Wang, H. F. and Zhang, W. and Hu, N. and Tan, L. and Sun, L. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.10.075},
  pmid    = {24184202},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.10.075}
}

@article{su2018-29322490,
  author  = {Su, W. H. and Shi, Z. H. and Liu, S. L. and Wang, X. D. and Liu, S. and Ji, Y.},
  title   = {{The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations}},
  journal = {Annals of human genetics},
  year    = {2018},
  doi     = {10.1111/ahg.12241},
  pmid    = {29322490},
  url     = {https://doi.org/10.1111/ahg.12241}
}

@article{reitz2013-1f8a1527,
  author  = {Reitz, Christiane and Mayeux, Richard P},
  title   = {{TREM2 and Neurodegenerative Disease}},
  journal = {New England Journal of Medicine},
  year    = {2013},
  doi     = {10.1056/nejmc1306509},
  url     = {https://doi.org/10.1056/nejmc1306509}
}

@article{colonna2016-26911435,
  author  = {Colonna, M. and Wang, Y.},
  title   = {{TREM2 variants: new keys to decipher Alzheimer disease pathogenesis}},
  journal = {Nature reviews. Neuroscience},
  year    = {2016},
  doi     = {10.1038/nrn.2016.7},
  pmid    = {26911435},
  url     = {https://doi.org/10.1038/nrn.2016.7}
}

@article{colonna2003-12776204,
  author  = {Colonna, M.},
  title   = {{TREMs in the immune system and beyond}},
  journal = {Nature reviews. Immunology},
  year    = {2003},
  doi     = {10.1038/nri1106},
  pmid    = {12776204},
  url     = {https://doi.org/10.1038/nri1106}
}

@article{konishi2018-30127720,
  author  = {Konishi, H. and Kiyama, H.},
  title   = {{Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2018},
  doi     = {10.3389/fncel.2018.00206},
  pmid    = {30127720},
  url     = {https://doi.org/10.3389/fncel.2018.00206}
}

@article{tan2023-36889359,
  author  = {Tan, J. and Fan, W. and Liu, T. and Zhu, B. and Liu, Y. and Wang, S. and Wu, J. and Liu, J. and others},
  title   = {{TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma}},
  journal = {Journal of hepatology},
  year    = {2023},
  doi     = {10.1016/j.jhep.2023.02.032},
  pmid    = {36889359},
  url     = {https://doi.org/10.1016/j.jhep.2023.02.032}
}

@article{patterson2023-38646596,
  author  = {Patterson, M. T. and Firulyova, M. M. and Xu, Y. and Hillman, H. and Bishop, C. and Zhu, A. and Hickok, G. H. and Schrank, P. R. and others},
  title   = {{Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis}},
  journal = {Nature cardiovascular research},
  year    = {2023},
  doi     = {10.1038/s44161-023-00354-3},
  pmid    = {38646596},
  url     = {https://doi.org/10.1038/s44161-023-00354-3}
}

@article{thornton2017-28855301,
  author  = {Thornton, P. and Sevalle, J. and Deery, M. J. and Fraser, G. and Zhou, Y. and Ståhl, S. and Franssen, E. H. and Dodd, R. B. and others},
  title   = {{TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201707673},
  pmid    = {28855301},
  url     = {https://doi.org/10.15252/emmm.201707673}
}

@article{meilandt2020-31980586,
  author  = {Meilandt, W. J. and Ngu, H. and Gogineni, A. and Lalehzadeh, G. and Lee, S. H. and Srinivasan, K. and Imperio, J. and Wu, T. and others},
  title   = {{Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.1871-19.2019},
  pmid    = {31980586},
  url     = {https://doi.org/10.1523/jneurosci.1871-19.2019}
}

@article{otero2012-22312126,
  author  = {Otero, K. and Shinohara, M. and Zhao, H. and Cella, M. and Gilfillan, S. and Colucci, A. and Faccio, R. and Ross, F. P. and others},
  title   = {{TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis}},
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  year    = {2012},
  doi     = {10.4049/jimmunol.1102836},
  pmid    = {22312126},
  url     = {https://doi.org/10.4049/jimmunol.1102836}
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@article{hauremirande2022-36002854,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Ehrlich, M. E. and Gandy, S.},
  title   = {{Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00552-w},
  pmid    = {36002854},
  url     = {https://doi.org/10.1186/s13024-022-00552-w}
}

@article{painter2015-26337043,
  author  = {Painter, M. M. and Atagi, Y. and Liu, C. C. and Rademakers, R. and Xu, H. and Fryer, J. D. and Bu, G.},
  title   = {{TREM2 in CNS homeostasis and neurodegenerative disease}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0040-9},
  pmid    = {26337043},
  url     = {https://doi.org/10.1186/s13024-015-0040-9}
}

@article{lessard2018-30341064,
  author  = {Lessard, C. B. and Malnik, S. L. and Zhou, Y. and Ladd, T. B. and Cruz, P. E. and Ran, Y. and Mahan, T. E. and Chakrabaty, P. and others},
  title   = {{High-affinity interactions and signal transduction between Aβ oligomers and TREM2}},
  journal = {EMBO molecular medicine},
  year    = {2018},
  doi     = {10.15252/emmm.201809027},
  pmid    = {30341064},
  url     = {https://doi.org/10.15252/emmm.201809027}
}

@article{bhattacharjee2016-26949937,
  author  = {Bhattacharjee, S. and Zhao, Y. and Dua, P. and Rogaev, E. I. and Lukiw, W. J.},
  title   = {{microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration}},
  journal = {PloS one},
  year    = {2016},
  doi     = {10.1371/journal.pone.0150211},
  pmid    = {26949937},
  url     = {https://doi.org/10.1371/journal.pone.0150211}
}

@article{guerreiro2013-23870839,
  author  = {Guerreiro, R. and Bilgic, B. and Guven, G. and Brás, J. and Rohrer, J. and Lohmann, E. and Hanagasi, H. and Gurvit, H. and others},
  title   = {{Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.06.005},
  pmid    = {23870839},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.06.005}
}

@article{yofe2023-37756565,
  author  = {Yofe, I. and Shami, T. and Cohen, N. and Landsberger, T. and Sheban, F. and Stoler-Barak, L. and Yalin, A. and Phan, T. S. and others},
  title   = {{Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary}},
  journal = {Cancer discovery},
  year    = {2023},
  doi     = {10.1158/2159-8290.cd-23-0299},
  pmid    = {37756565},
  url     = {https://doi.org/10.1158/2159-8290.cd-23-0299}
}

@article{prokop2019-31350575,
  author  = {Prokop, S. and Miller, K. R. and Labra, SR. and Pitkin, R. M. and Hoxha, K. and Narasimhan, S. and Changolkar, L. and Rosenbloom, A. and others},
  title   = {{Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02048-2},
  pmid    = {31350575},
  url     = {https://doi.org/10.1007/s00401-019-02048-2}
}

@article{shirotani2019-31101881,
  author  = {Shirotani, K. and Hori, Y. and Yoshizaki, R. and Higuchi, E. and Colonna, M. and Saito, T. and Hashimoto, S. and others},
  title   = {{Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-43535-6},
  pmid    = {31101881},
  url     = {https://doi.org/10.1038/s41598-019-43535-6}
}

@article{huang2024-37917301,
  author  = {Huang, P. and Zhang, Z. and Zhang, P. and Feng, J. and Xie, J. and Zheng, Y. and Liang, X. and Zhu, B. and others},
  title   = {{TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells}},
  journal = {Molecular neurobiology},
  year    = {2024},
  doi     = {10.1007/s12035-023-03713-0},
  pmid    = {37917301},
  url     = {https://doi.org/10.1007/s12035-023-03713-0}
}

@article{ohrfelt2016-26754805,
  author  = {Öhrfelt, A. and Axelsson, M. and Malmeström, C. and Novakova, L. and Heslegrave, A. and Blennow, K. and Lycke, J. and Zetterberg, H.},
  title   = {{Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone}},
  journal = {Multiple sclerosis (Houndmills, Basingstoke, England)},
  year    = {2016},
  doi     = {10.1177/1352458515624558},
  pmid    = {26754805},
  url     = {https://doi.org/10.1177/1352458515624558}
}

@article{ma2020-32276587,
  author  = {Ma, L. Z. and Tan, L. and Bi, Y. L. and Shen, X. N. and Xu, W. and Ma, Y. H. and Li, H. Q. and Dong, Q. and others},
  title   = {{Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00374-8},
  pmid    = {32276587},
  url     = {https://doi.org/10.1186/s13024-020-00374-8}
}

@article{kotredes2021-34707490,
  author  = {Kotredes, K. P. and Oblak, A. and Pandey, R. S. and Lin, P. B. and Garceau, D. and Williams, H. and Uyar, A. and O'Rourke, R. and others},
  title   = {{Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.735524},
  pmid    = {34707490},
  url     = {https://doi.org/10.3389/fnagi.2021.735524}
}

@article{belsare2022-35082148,
  author  = {Belsare, K. D. and Wu, H. and Mondal, D. and Bond, A. and Castillo, E. and Jin, J. and Jo, H. and Roush, A. E. and others},
  title   = {{Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2022},
  doi     = {10.1073/pnas.2114486119},
  pmid    = {35082148},
  url     = {https://doi.org/10.1073/pnas.2114486119}
}

@article{liao2026-42230432,
  author  = {Liao, Y. and Ye, S. and Zhao, L. and Zhou, M. and Wen, Y. and Zhu, Y. and Huang, J. and Zhang, L. and others},
  title   = {{Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies}},
  journal = {Molecular neurobiology},
  year    = {2026},
  doi     = {10.1007/s12035-026-05925-6},
  pmid    = {42230432},
  url     = {https://doi.org/10.1007/s12035-026-05925-6}
}

@article{yin2024-38915213,
  author  = {Yin, Y. and Yang, H. and Li, R. and Wu, G. and Qin, Q. and Tang, Y.},
  title   = {{A systematic review of the role of TREM2 in Alzheimer's disease}},
  journal = {Chinese medical journal},
  year    = {2024},
  doi     = {10.1097/cm9.0000000000003000},
  pmid    = {38915213},
  url     = {https://doi.org/10.1097/cm9.0000000000003000}
}

@article{lu2015-26037549,
  author  = {Lu, Y. and Liu, W. and Wang, X.},
  title   = {{TREM2 variants and risk of Alzheimer's disease: a meta-analysis}},
  journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
  year    = {2015},
  doi     = {10.1007/s10072-015-2274-2},
  pmid    = {26037549},
  url     = {https://doi.org/10.1007/s10072-015-2274-2}
}

@article{diazlucena2021-33881612,
  author  = {Diaz-Lucena, Daniela and Kruse, Niels and Thüne, Katrin and Schmitz, Matthias and Villar-Piqué, Anna and da Cunha, Jose Eriton Gomes and Hermann, Peter and López-Pérez, Óscar and others},
  title   = {{TREM2 expression in the brain and biological fluids in prion diseases}},
  journal = {Acta neuropathologica},
  year    = {2021},
  doi     = {10.1007/s00401-021-02296-1},
  pmid    = {33881612},
  url     = {https://doi.org/10.1007/s00401-021-02296-1}
}

@article{peng2010-20484116,
  author  = {Peng, Q. and Malhotra, S. and Torchia, J. A. and Kerr, W. G. and Coggeshall, K. M. and Humphrey, M. B.},
  title   = {{TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1}},
  journal = {Science signaling},
  year    = {2010},
  doi     = {10.1126/scisignal.2000500},
  pmid    = {20484116},
  url     = {https://doi.org/10.1126/scisignal.2000500}
}

@article{yeh2017-28442216,
  author  = {Yeh, F. L. and Hansen, D. V. and Sheng, M.},
  title   = {{TREM2, Microglia, and Neurodegenerative Diseases}},
  journal = {Trends in molecular medicine},
  year    = {2017},
  doi     = {10.1016/j.molmed.2017.03.008},
  pmid    = {28442216},
  url     = {https://doi.org/10.1016/j.molmed.2017.03.008}
}

@article{matarin2015-25620700,
  author  = {Matarin, M. and Salih, D. A. and Yasvoina, M. and Cummings, D. M. and Guelfi, S. and Liu, W. and Nahaboo Solim, M. A. and Moens, T. G. and others},
  title   = {{A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology}},
  journal = {Cell reports},
  year    = {2015},
  doi     = {10.1016/j.celrep.2014.12.041},
  pmid    = {25620700},
  url     = {https://doi.org/10.1016/j.celrep.2014.12.041}
}

@article{andreone2020-32514138,
  author  = {Andreone, B. J. and Przybyla, L. and Llapashtica, C. and Rana, A. and Davis, S. S. and van Lengerich, B. and Lin, K. and Shi, J. and others},
  title   = {{Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia}},
  journal = {Nature neuroscience},
  year    = {2020},
  doi     = {10.1038/s41593-020-0650-6},
  pmid    = {32514138},
  url     = {https://doi.org/10.1038/s41593-020-0650-6}
}

@article{mecca2018-29361745,
  author  = {Mecca, C. and Giambanco, I. and Donato, R. and Arcuri, C.},
  title   = {{Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms19010318},
  pmid    = {29361745},
  url     = {https://doi.org/10.3390/ijms19010318}
}

@article{qin2021-33516818,
  author  = {Qin, Q. and Teng, Z. and Liu, C. and Li, Q. and Yin, Y. and Tang, Y.},
  title   = {{TREM2, microglia, and Alzheimer's disease}},
  journal = {Mechanisms of ageing and development},
  year    = {2021},
  doi     = {10.1016/j.mad.2021.111438},
  pmid    = {33516818},
  url     = {https://doi.org/10.1016/j.mad.2021.111438}
}

@article{feuerbach2017-28923481,
  author  = {Feuerbach, D. and Schindler, P. and Barske, C. and Joller, S. and Beng-Louka, E. and Worringer, K. A. and Kommineni, S. and Kaykas, A. and others},
  title   = {{ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157}},
  journal = {Neuroscience letters},
  year    = {2017},
  doi     = {10.1016/j.neulet.2017.09.034},
  pmid    = {28923481},
  url     = {https://doi.org/10.1016/j.neulet.2017.09.034}
}

@article{garciareitboeck2018-30157425,
  author  = {Garcia-Reitboeck, P. and Phillips, A. and Piers, T. M. and Villegas-Llerena, C. and Butler, M. and Mallach, A. and Rodrigues, C. and Arber, C. E. and others},
  title   = {{Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis}},
  journal = {Cell reports},
  year    = {2018},
  doi     = {10.1016/j.celrep.2018.07.094},
  pmid    = {30157425},
  url     = {https://doi.org/10.1016/j.celrep.2018.07.094}
}

@article{piers2020-31907987,
  author  = {Piers, T. M. and Cosker, K. and Mallach, A. and Johnson, G. T. and Guerreiro, R. and Hardy, J. and Pocock, J. M.},
  title   = {{A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2020},
  doi     = {10.1096/fj.201902447r},
  pmid    = {31907987},
  url     = {https://doi.org/10.1096/fj.201902447r}
}

@article{piollet2024-38974464,
  author  = {Piollet, M. and Porsch, F. and Rizzo, G. and Kapser, F. and Schulz, D. J. J. and Kiss, M. G. and Schlepckow, K. and Morenas-Rodriguez, E. and others},
  title   = {{TREM2 protects from atherosclerosis by limiting necrotic core formation}},
  journal = {Nature cardiovascular research},
  year    = {2024},
  doi     = {10.1038/s44161-024-00429-9},
  pmid    = {38974464},
  url     = {https://doi.org/10.1038/s44161-024-00429-9}
}

@article{fang2024-38617547,
  author  = {Fang, C. and Zhong, R. and Lu, S. and Yu, G. and Liu, Z. and Yan, C. and Gao, J. and Tang, Y. and others},
  title   = {{TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis}},
  journal = {International journal of biological sciences},
  year    = {2024},
  doi     = {10.7150/ijbs.91519},
  pmid    = {38617547},
  url     = {https://doi.org/10.7150/ijbs.91519}
}

@article{wei2024-38042110,
  author  = {Wei, W. and Zhang, L. and Xin, W. and Pan, Y. and Tatenhorst, L. and Hao, Z. and Gerner, S. T. and Huber, S. and others},
  title   = {{TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2024},
  doi     = {10.1016/j.biopha.2023.115962},
  pmid    = {38042110},
  url     = {https://doi.org/10.1016/j.biopha.2023.115962}
}

@article{jiang2016-27067662,
  author  = {Jiang, T. and Tan, L. and Chen, Q. and Tan, M. S. and Zhou, J. S. and Zhu, X. C. and Lu, H. and Wang, H. F. and others},
  title   = {{A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.02.023},
  pmid    = {27067662},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.02.023}
}

@article{brendel2017-28197095,
  author  = {Brendel, M. and Kleinberger, G. and Probst, F. and Jaworska, A. and Overhoff, F. and Blume, T. and Albert, N. L. and Carlsen, J. and others},
  title   = {{Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00008},
  pmid    = {28197095},
  url     = {https://doi.org/10.3389/fnagi.2017.00008}
}

@article{jairaman2022-35191835,
  author  = {Jairaman, A. and McQuade, A. and Granzotto, A. and Kang, Y. J. and Chadarevian, J. P. and Gandhi, S. and Parker, I. and Smith, I. and others},
  title   = {{TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia}},
  journal = {eLife},
  year    = {2022},
  doi     = {10.7554/elife.73021},
  pmid    = {35191835},
  url     = {https://doi.org/10.7554/elife.73021}
}

@article{liebold2023-36766683,
  author  = {Liebold, I. and Meyer, S. and Heine, M. and Kuhl, A. and Witt, J. and Eissing, L. and Fischer, A. W. and Koop, A. C. and others},
  title   = {{TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD}},
  journal = {Cells},
  year    = {2023},
  doi     = {10.3390/cells12030341},
  pmid    = {36766683},
  url     = {https://doi.org/10.3390/cells12030341}
}

@article{sharif2021-33627323,
  author  = {Sharif, O. and Brunner, J. S. and Korosec, A. and Martins, R. and Jais, A. and Snijder, B. and Vogel, A. and Caldera, M. and others},
  title   = {{Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages}},
  journal = {Diabetes},
  year    = {2021},
  doi     = {10.2337/db20-0572},
  pmid    = {33627323},
  url     = {https://doi.org/10.2337/db20-0572}
}

@article{bouchon2000-10799849,
  author  = {Bouchon, Axel and Dietrich, Jes and Colonna, Marco},
  title   = {{Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes}},
  journal = {The Journal of Immunology},
  year    = {2000},
  doi     = {10.4049/jimmunol.164.10.4991},
  pmid    = {10799849},
  url     = {https://doi.org/10.4049/jimmunol.164.10.4991}
}

@article{wunderlich2013-24078628,
  author  = {Wunderlich, P. and Glebov, K. and Kemmerling, N. and Tien, N. T. and Neumann, H. and Walter, J.},
  title   = {{Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m113.517540},
  pmid    = {24078628},
  url     = {https://doi.org/10.1074/jbc.m113.517540}
}

@article{kober2017-28432014,
  author  = {Kober, D. L. and Brett, T. J.},
  title   = {{TREM2-Ligand Interactions in Health and Disease}},
  journal = {Journal of molecular biology},
  year    = {2017},
  doi     = {10.1016/j.jmb.2017.04.004},
  pmid    = {28432014},
  url     = {https://doi.org/10.1016/j.jmb.2017.04.004}
}

@article{zhang2023-36635449,
  author  = {Zhang, K. and Wang, Y. and Chen, S. and Mao, J. and Jin, Y. and Ye, H. and Zhang, Y. and Liu, X. and others},
  title   = {{TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis}},
  journal = {Nature metabolism},
  year    = {2023},
  doi     = {10.1038/s42255-022-00715-5},
  pmid    = {36635449},
  url     = {https://doi.org/10.1038/s42255-022-00715-5}
}

@article{hickman2014-24355566,
  author  = {Hickman, S. E. and El Khoury, J.},
  title   = {{TREM2 and the neuroimmunology of Alzheimer's disease}},
  journal = {Biochemical pharmacology},
  year    = {2014},
  doi     = {10.1016/j.bcp.2013.11.021},
  pmid    = {24355566},
  url     = {https://doi.org/10.1016/j.bcp.2013.11.021}
}

@article{xiang2016-27402340,
  author  = {Xiang, X. and Werner, G. and Bohrmann, B. and Liesz, A. and Mazaheri, F. and Capell, A. and Feederle, R. and Knuesel, I. and others},
  title   = {{TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201606370},
  pmid    = {27402340},
  url     = {https://doi.org/10.15252/emmm.201606370}
}

@article{jiang2016-26802771,
  author  = {Jiang, T. and Zhang, Y. D. and Chen, Q. and Gao, Q. and Zhu, X. C. and Zhou, J. S. and Shi, J. Q. and Lu, H. and others},
  title   = {{TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice}},
  journal = {Neuropharmacology},
  year    = {2016},
  doi     = {10.1016/j.neuropharm.2016.01.028},
  pmid    = {26802771},
  url     = {https://doi.org/10.1016/j.neuropharm.2016.01.028}
}

@article{wang2020-33065553,
  author  = {Wang, Y. and Lin, Y. and Wang, L. and Zhan, H. and Luo, X. and Zeng, Y. and Wu, W. and Zhang, X. and others},
  title   = {{TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice}},
  journal = {Aging},
  year    = {2020},
  doi     = {10.18632/aging.104104},
  pmid    = {33065553},
  url     = {https://doi.org/10.18632/aging.104104}
}

@article{savage2015-25904803,
  author  = {Savage, J. C. and Jay, T. and Goduni, E. and Quigley, C. and Mariani, M. M. and Malm, T. and Ransohoff, R. M. and Lamb, B. T. and others},
  title   = {{Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.4586-14.2015},
  pmid    = {25904803},
  url     = {https://doi.org/10.1523/jneurosci.4586-14.2015}
}

@article{kobayashi2016-27798193,
  author  = {Kobayashi, M. and Konishi, H. and Sayo, A. and Takai, T. and Kiyama, H.},
  title   = {{TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.1238-16.2016},
  pmid    = {27798193},
  url     = {https://doi.org/10.1523/jneurosci.1238-16.2016}
}

@article{zhu2022-36056435,
  author  = {Zhu, B. and Liu, Y. and Hwang, S. and Archuleta, K. and Huang, H. and Campos, A. and Murad, R. and Piña-Crespo, J. and others},
  title   = {{Trem2 deletion enhances tau dispersion and pathology through microglia exosomes}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00562-8},
  pmid    = {36056435},
  url     = {https://doi.org/10.1186/s13024-022-00562-8}
}

@article{yan2022-36463233,
  author  = {Yan, J. and Zhang, Y. and Wang, L. and Li, Z. and Tang, S. and Wang, Y. and Gu, N. and Sun, X. and others},
  title   = {{TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02651-3},
  pmid    = {36463233},
  url     = {https://doi.org/10.1186/s12974-022-02651-3}
}

@article{zheng2016-27143430,
  author  = {Zheng, H. and Liu, C. C. and Atagi, Y. and Chen, X. F. and Jia, L. and Yang, L. and He, W. and Zhang, X. and others},
  title   = {{Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.03.004},
  pmid    = {27143430},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.03.004}
}

@article{chen2023-37563723,
  author  = {Chen, J. and Zhu, T. and Jiang, G. and Zeng, Q. and Li, Z. and Huang, X.},
  title   = {{Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer}},
  journal = {Molecular cancer},
  year    = {2023},
  doi     = {10.1186/s12943-023-01830-x},
  pmid    = {37563723},
  url     = {https://doi.org/10.1186/s12943-023-01830-x}
}

@article{linnartzgerlach2019-30548312,
  author  = {Linnartz-Gerlach, B. and Bodea, L. G. and Klaus, C. and Ginolhac, A. and Halder, R. and Sinkkonen, L. and Walter, J. and Colonna, M. and others},
  title   = {{TREM2 triggers microglial density and age-related neuronal loss}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23563},
  pmid    = {30548312},
  url     = {https://doi.org/10.1002/glia.23563}
}

@article{jiang2015-26364736,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhou, J. S. and Cao, L. and Tan, M. S. and Wang, H. F. and Chen, Q. and others},
  title   = {{Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2015.08.019},
  pmid    = {26364736},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.08.019}
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@article{zhong2024-38788719,
  author  = {Zhong, J. and Xing, X. and Gao, Y. and Pei, L. and Lu, C. and Sun, H. and Lai, Y. and Du, K. and others},
  title   = {{Distinct roles of TREM2 in central nervous system cancers and peripheral cancers}},
  journal = {Cancer cell},
  year    = {2024},
  doi     = {10.1016/j.ccell.2024.05.001},
  pmid    = {38788719},
  url     = {https://doi.org/10.1016/j.ccell.2024.05.001}
}

@article{zhou2022-35359989,
  author  = {Zhou, L. and Wang, M. and Guo, H. and Hou, J. and Zhang, Y. and Li, M. and Wu, X. and Chen, X. and others},
  title   = {{Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.848367},
  pmid    = {35359989},
  url     = {https://doi.org/10.3389/fimmu.2022.848367}
}

@article{fahrenhold2018-28987033,
  author  = {Fahrenhold, M. and Rakic, S. and Classey, J. and Brayne, C. and Ince, P. G. and Nicoll, J. A. R. and Boche, D. and MRC-CFAS},
  title   = {{TREM2 expression in the human brain: a marker of monocyte recruitment?}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2018},
  doi     = {10.1111/bpa.12564},
  pmid    = {28987033},
  url     = {https://doi.org/10.1111/bpa.12564}
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@article{diluccia2024-38758808,
  author  = {Di Luccia, B. and Molgora, M. and Khantakova, D. and Jaeger, N. and Chang, H. W. and Czepielewski, R. S. and Helmink, B. A. and Onufer, E. J. and others},
  title   = {{TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy}},
  journal = {Science immunology},
  year    = {2024},
  doi     = {10.1126/sciimmunol.adi5374},
  pmid    = {38758808},
  url     = {https://doi.org/10.1126/sciimmunol.adi5374}
}

@article{henn2021-34851663,
  author  = {Henn, D. and Chen, K. and Fehlmann, T. and Trotsyuk, A. A. and Sivaraj, D. and Maan, Z. N. and Bonham, C. A. and Barrera, J. A. and others},
  title   = {{Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2+ macrophages}},
  journal = {Science advances},
  year    = {2021},
  doi     = {10.1126/sciadv.abi4528},
  pmid    = {34851663},
  url     = {https://doi.org/10.1126/sciadv.abi4528}
}

@article{che2026-41512220,
  author  = {Che, Yanfei and Yu, Ziman and Ji, Songjie and Yang, Dan},
  title   = {{Decoding TREM2 Signaling Pathways}},
  journal = {Neurology Neuroimmunology \& Neuroinflammation},
  year    = {2026},
  doi     = {10.1212/nxi.0000000000200527},
  pmid    = {41512220},
  url     = {https://doi.org/10.1212/nxi.0000000000200527}
}

@article{ndiaye2009-19171755,
  author  = {N’Diaye, Elsa-Noah and Branda, Catherine and Branda, Steven S. and Nevarez, Lisette and Colonna, Marco and Lowell, Clifford A. and Hamerman, Jessica A. and Seaman, William E.},
  title   = {{TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria}},
  journal = {The Journal of Cell Biology},
  year    = {2009},
  doi     = {10.1083/jcb.200808080},
  pmid    = {19171755},
  url     = {https://doi.org/10.1083/jcb.200808080}
}

@article{gate2021-34648304,
  author  = {Gate, D. and Tapp, E. and Leventhal, O. and Shahid, M. and Nonninger, T. J. and Yang, A. C. and Strempfl, K. and Unger, M. S. and others},
  title   = {{CD4 + T cells contribute to neurodegeneration in Lewy body dementia}},
  journal = {Science (New York, N.Y.)},
  year    = {2021},
  doi     = {10.1126/science.abf7266},
  pmid    = {34648304},
  url     = {https://doi.org/10.1126/science.abf7266}
}

@article{shi2022-36408515,
  author  = {Shi, Xiaolei and Zhong, Xiaomei and Zhou, Huarong and Zhou, Nan and Hu, Yachun and Ning, Yuping and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum}},
  journal = {Frontiers in neurology},
  year    = {2022},
  doi     = {10.3389/fneur.2022.961842},
  pmid    = {36408515},
  url     = {https://doi.org/10.3389/fneur.2022.961842}
}

@article{feiten2026-41580393,
  author  = {Feiten, Astrid F and Dahm, Kilian and Schlepckow, Kai and van Lengerich, Bettina and Suh, Jung H and Reifschneider, Anika and Wefers, Benedikt and Bartos, Laura M and others},
  title   = {{TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68706-8},
  pmid    = {41580393},
  url     = {https://doi.org/10.1038/s41467-026-68706-8}
}

@article{abdulkhaliq2026-41792456,
  author  = {Abdulkhaliq, Altaf A and Alasiri, Glowi and Kim, Bonglee and Khan, Johra and Ajoolabady, Amir and Yousof, Shimaa Mohammad and Ren, Jun and Tuomilehto, Jaakko and others},
  title   = {{TREM2 in neurodegeneration and diseases}},
  journal = {Molecular psychiatry},
  year    = {2026},
  doi     = {10.1038/s41380-026-03505-7},
  pmid    = {41792456},
  url     = {https://doi.org/10.1038/s41380-026-03505-7}
}

@article{belmontrausch2026-42265098,
  author  = {Belmont-Rausch, Dylan M and Ludwig, Mette Q and Bentsen, Marie A and Hansen, Stine N and Secher, Anna and Holst, Dorte and Moreno, Jaime and Das, Vivek and others},
  title   = {{Semaglutide attenuates neuroinflammation in male mice}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-74038-4},
  pmid    = {42265098},
  url     = {https://doi.org/10.1038/s41467-026-74038-4}
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@article{ouyang2026-42150695,
  author  = {Ouyang, Xiaoxue and Chia, Rachel S L and Chai, Yuek Ling and Chong, Joyce R and Sim, Ming Ann and Jo, Dong-Gyu and Arumugam, Thiruma V and Sethi, Gautam and others},
  title   = {{Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia}},
  journal = {Biochemical pharmacology},
  year    = {2026},
  doi     = {10.1016/j.bcp.2026.118077},
  pmid    = {42150695},
  url     = {https://doi.org/10.1016/j.bcp.2026.118077}
}

@article{gaire2026-41571675,
  author  = {Gaire, Bhakta Prasad and Koronyo, Yosef and Vit, Jean-Philippe and Hutton, Alexandre and Subedi, Lalita and Fuchs, Dieu-Trang and Swerdlow, Natalie and Rentsendorj, Altan and others},
  title   = {{Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68580-4},
  pmid    = {41571675},
  url     = {https://doi.org/10.1038/s41467-026-68580-4}
}

@article{lee2026-41789727,
  author  = {Lee, Jeongmi and Cho, Yongeun and Choi, Bo Youn and Kim, Hark Kyun and Lee, Yeongyeong and Kim, Eunae and Han, Jihoon and Sul, Jae Hoon and others},
  title   = {{HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag089},
  pmid    = {41789727},
  url     = {https://doi.org/10.1093/brain/awag089}
}

@article{shen2026-42489128,
  author  = {Shen, Qi and Chang, Haocai and Li, Junyu and Guo, Haoyun and Shi, Wenbin and Yan, Yihua and Ouyang, Wenwen and Zhang, Zhan and others},
  title   = {{Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag247},
  pmid    = {42489128},
  url     = {https://doi.org/10.1093/brain/awag247}
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@article{wolfe2018-30587772,
  author  = {Wolfe, C. M. and Fitz, N. F. and Nam, K. N. and Lefterov, I. and Koldamova, R.},
  title   = {{The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms20010081},
  pmid    = {30587772},
  url     = {https://doi.org/10.3390/ijms20010081}
}

@article{zhong2015-25957402,
  author  = {Zhong, L. and Chen, X. F. and Zhang, Z. L. and Wang, Z. and Shi, X. Z. and Xu, K. and Zhang, Y. W. and Xu, H. and others},
  title   = {{DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.645986},
  pmid    = {25957402},
  url     = {https://doi.org/10.1074/jbc.m115.645986}
}

@article{seno2009-19109436,
  author  = {Seno, H. and Miyoshi, H. and Brown, S. L. and Geske, M. J. and Colonna, M. and Stappenbeck, T. S.},
  title   = {{Efficient colonic mucosal wound repair requires Trem2 signaling}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0803343106},
  pmid    = {19109436},
  url     = {https://doi.org/10.1073/pnas.0803343106}
}

@article{brownjohn2018-29606617,
  author  = {Brownjohn, P. W. and Smith, J. and Solanki, R. and Lohmann, E. and Houlden, H. and Hardy, J. and Dietmann, S. and Livesey, F. J.},
  title   = {{Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia}},
  journal = {Stem cell reports},
  year    = {2018},
  doi     = {10.1016/j.stemcr.2018.03.003},
  pmid    = {29606617},
  url     = {https://doi.org/10.1016/j.stemcr.2018.03.003}
}

@article{shi2022-35672148,
  author  = {Shi, Q. and Chang, C. and Saliba, A. and Bhat, M. A.},
  title   = {{Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2022},
  doi     = {10.1523/jneurosci.2427-21.2022},
  pmid    = {35672148},
  url     = {https://doi.org/10.1523/jneurosci.2427-21.2022}
}

@article{sieber2013-23301011,
  author  = {Sieber, M. W. and Jaenisch, N. and Brehm, M. and Guenther, M. and Linnartz-Gerlach, B. and Neumann, H. and Witte, O. W. and Frahm, C.},
  title   = {{Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0052982},
  pmid    = {23301011},
  url     = {https://doi.org/10.1371/journal.pone.0052982}
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@article{fassler2021-33422057,
  author  = {Fassler, M. and Rappaport, M. S. and Cuño, C. B. and George, J.},
  title   = {{Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-020-01980-5},
  pmid    = {33422057},
  url     = {https://doi.org/10.1186/s12974-020-01980-5}
}

@article{patterson2024-38695172,
  author  = {Patterson, M. T. and Xu, Y. and Hillman, H. and Osinski, V. and Schrank, P. R. and Kennedy, A. E. and Barrow, F. and Zhu, A. and others},
  title   = {{Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2024},
  doi     = {10.1161/atvbaha.124.320797},
  pmid    = {38695172},
  url     = {https://doi.org/10.1161/atvbaha.124.320797}
}

@article{schoch2021-34187891,
  author  = {Schoch, K. M. and Ezerskiy, L. A. and Morhaus, M. M. and Bannon, R. N. and Sauerbeck, A. D. and Shabsovich, M. and Jafar-Nejad, P. and Rigo, F. and others},
  title   = {{Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice}},
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  year    = {2021},
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@article{riversauty2024-39229486,
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@article{molgora2023-36989543,
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  title   = {{TREM2: A new player in the tumor microenvironment}},
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@article{kober2020-33090700,
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@article{yang2023-36259513,
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  title   = {{Platinum-Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment}},
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  year    = {2023},
  doi     = {10.1002/anie.202213337},
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  title   = {{Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury}},
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  title   = {{TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria}},
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@article{qu2020-33139402,
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  year    = {2020},
  doi     = {10.1523/jneurosci.2193-20.2020},
  pmid    = {33139402},
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  title   = {{Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice}},
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  year    = {2020},
  doi     = {10.1186/s13024-020-00409-0},
  pmid    = {33115519},
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  title   = {{Soluble TREM2 and Alzheimer-related biomarker trajectories in the blood of patients with diabetes based on their cognitive status}},
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  doi     = {10.1016/j.diabres.2022.110121},
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  title   = {{Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction}},
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  title   = {{TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway}},
  journal = {Experimental neurology},
  year    = {2021},
  doi     = {10.1016/j.expneurol.2020.113506},
  pmid    = {33065077},
  url     = {https://doi.org/10.1016/j.expneurol.2020.113506}
}

@article{jiang2013-23407992,
  author  = {Jiang, T. and Yu, J. T. and Zhu, X. C. and Tan, L.},
  title   = {{TREM2 in Alzheimer's disease}},
  journal = {Molecular neurobiology},
  year    = {2013},
  doi     = {10.1007/s12035-013-8424-8},
  pmid    = {23407992},
  url     = {https://doi.org/10.1007/s12035-013-8424-8}
}

@article{hu2014-24002183,
  author  = {Hu, N. and Tan, M. S. and Yu, J. T. and Sun, L. and Tan, L. and Wang, Y. L. and Jiang, T.},
  title   = {{Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-130854},
  pmid    = {24002183},
  url     = {https://doi.org/10.3233/jad-130854}
}

@article{jay2019-31265185,
  author  = {Jay, T. R. and von Saucken, V. E. and Muñoz, B. and Codocedo, J. F. and Atwood, B. K. and Lamb, B. T. and Landreth, G. E.},
  title   = {{TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23664},
  pmid    = {31265185},
  url     = {https://doi.org/10.1002/glia.23664}
}

@article{lee2021-34965428,
  author  = {Lee, S. H. and Rezzonico, M. G. and Friedman, B. A. and Huntley, M. H. and Meilandt, W. J. and Pandey, S. and Chen, Y. J. and Easton, A. and others},
  title   = {{TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.110158},
  pmid    = {34965428},
  url     = {https://doi.org/10.1016/j.celrep.2021.110158}
}

@article{zheng2018-30532704,
  author  = {Zheng, H. and Cheng, B. and Li, Y. and Li, X. and Chen, X. and Zhang, Y. W.},
  title   = {{TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00395},
  pmid    = {30532704},
  url     = {https://doi.org/10.3389/fnagi.2018.00395}
}

@article{zhong2017-28680398,
  author  = {Zhong, L. and Zhang, Z. L. and Li, X. and Liao, C. and Mou, P. and Wang, T. and Wang, Z. and others},
  title   = {{TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00204},
  pmid    = {28680398},
  url     = {https://doi.org/10.3389/fnagi.2017.00204}
}

@article{celarain2016-27051467,
  author  = {Celarain, N. and Sánchez-Ruiz de Gordoa, J. and Zelaya, M. V. and Roldán, M. and Larumbe, R. and Pulido, L. and Echavarri, C. and Mendioroz, M.},
  title   = {{TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus}},
  journal = {Clinical epigenetics},
  year    = {2016},
  doi     = {10.1186/s13148-016-0202-9},
  pmid    = {27051467},
  url     = {https://doi.org/10.1186/s13148-016-0202-9}
}

@article{xu2023-36829205,
  author  = {Xu, J. and Zhang, L. and Li, M. and He, X. and Luo, J. and Wu, R. and Hong, Z. and Zheng, H. and others},
  title   = {{TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02741-w},
  pmid    = {36829205},
  url     = {https://doi.org/10.1186/s12974-023-02741-w}
}

@article{fitz2020-32703241,
  author  = {Fitz, N. F. and Wolfe, C. M. and Playso, B. E. and Biedrzycki, R. J. and Lu, Y. and Nam, K. N. and Lefterov, I. and Koldamova, R.},
  title   = {{Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00394-4},
  pmid    = {32703241},
  url     = {https://doi.org/10.1186/s13024-020-00394-4}
}

@article{jiao2014-24866402,
  author  = {Jiao, B. and Liu, X. and Tang, B. and Hou, L. and Zhou, L. and Zhang, F. and Zhou, Y. and Guo, J. and others},
  title   = {{Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2014.04.025},
  pmid    = {24866402},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.04.025}
}

@article{tran2023-36803190,
  author  = {Tran, K. M. and Kawauchi, S. and Kramár, E. A. and Rezaie, N. and Liang, H. Y. and Sakr, J. S. and Gomez-Arboledas, A. and Arreola, M. A. and others},
  title   = {{A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00598-4},
  pmid    = {36803190},
  url     = {https://doi.org/10.1186/s13024-023-00598-4}
}

@article{peng2023-36662361,
  author  = {Peng, X. and Guo, H. and Zhang, X. and Yang, Z. and Ruganzu, J. B. and Wu, X. and Bi, W. and others},
  title   = {{TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-023-03217-x},
  pmid    = {36662361},
  url     = {https://doi.org/10.1007/s12035-023-03217-x}
}

@article{khantakova2022-35746551,
  author  = {Khantakova, D. and Brioschi, S. and Molgora, M.},
  title   = {{Exploring the Impact of TREM2 in Tumor-Associated Macrophages}},
  journal = {Vaccines},
  year    = {2022},
  doi     = {10.3390/vaccines10060943},
  pmid    = {35746551},
  url     = {https://doi.org/10.3390/vaccines10060943}
}

@article{sirkis2016-27589997,
  author  = {Sirkis, D. W. and Bonham, L. W. and Aparicio, R. E. and Geier, E. G. and Ramos, E. M. and Wang, Q. and Karydas, A. and Miller, Z. A. and others},
  title   = {{Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression}},
  journal = {Acta neuropathologica communications},
  year    = {2016},
  doi     = {10.1186/s40478-016-0367-7},
  pmid    = {27589997},
  url     = {https://doi.org/10.1186/s40478-016-0367-7}
}

@article{lichtenthaler2022-34689040,
  author  = {Lichtenthaler, S. F. and Tschirner, S. K. and Steiner, H.},
  title   = {{Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2}},
  journal = {Current opinion in neurobiology},
  year    = {2022},
  doi     = {10.1016/j.conb.2021.09.003},
  pmid    = {34689040},
  url     = {https://doi.org/10.1016/j.conb.2021.09.003}
}

@article{reich2020-33613545,
  author  = {Reich, M. and Paris, I. and Ebeling, M. and Dahm, N. and Schweitzer, C. and Reinhardt, D. and Schmucki, R. and Prasad, M. and others},
  title   = {{Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.617860},
  pmid    = {33613545},
  url     = {https://doi.org/10.3389/fimmu.2020.617860}
}

@article{yagi2025-40143815,
  author  = {Yagi, Hitomi and Boeck, Myriam and Neilsen, Katherine and Yang, Jay and Ko, Minji and Tomita, Yohei and Negishi, Kazuno and Fu, Zhongjie and others},
  title   = {{Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes—Brief Report}},
  journal = {Arteriosclerosis Thrombosis and Vascular Biology},
  year    = {2025},
  doi     = {10.1161/atvbaha.124.321809},
  pmid    = {40143815},
  url     = {https://doi.org/10.1161/atvbaha.124.321809}
}

@article{weber2020-31959733,
  author  = {Weber, G. E. and Koenig, K. A. and Khrestian, M. and Shao, Y. and Tuason, E. D. and Gramm, M. and Lal, D. and Leverenz, J. B. and others},
  title   = {{An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2020},
  doi     = {10.4049/jimmunol.1901166},
  pmid    = {31959733},
  url     = {https://doi.org/10.4049/jimmunol.1901166}
}

@article{guo2019-31370707,
  author  = {Guo, Y. and Wei, X. and Yan, H. and Qin, Y. and Yan, S. and Liu, J. and Zhao, Y. and Jiang, F. and others},
  title   = {{TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900992r},
  pmid    = {31370707},
  url     = {https://doi.org/10.1096/fj.201900992r}
}

@article{melchior2010-20640189,
  author  = {Melchior, B. and Garcia, A. E. and Hsiung, B. K. and Lo, K. M. and Doose, J. M. and Thrash, J. C. and Stalder, A. K. and Staufenbiel, M. and others},
  title   = {{Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease}},
  journal = {ASN neuro},
  year    = {2010},
  doi     = {10.1042/an20100010},
  pmid    = {20640189},
  url     = {https://doi.org/10.1042/an20100010}
}

@article{weng2021-33486152,
  author  = {Weng, Y. and Wang, H. and Li, L. and Feng, Y. and Xu, S. and Wang, Z.},
  title   = {{Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment}},
  journal = {Redox biology},
  year    = {2021},
  doi     = {10.1016/j.redox.2020.101849},
  pmid    = {33486152},
  url     = {https://doi.org/10.1016/j.redox.2020.101849}
}

@article{ren2018-29407460,
  author  = {Ren, M. and Guo, Y. and Wei, X. and Yan, S. and Qin, Y. and Zhang, X. and Jiang, F. and Lou, H.},
  title   = {{TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease}},
  journal = {Experimental neurology},
  year    = {2018},
  doi     = {10.1016/j.expneurol.2018.01.016},
  pmid    = {29407460},
  url     = {https://doi.org/10.1016/j.expneurol.2018.01.016}
}

@article{zhu2020-32401783,
  author  = {Zhu, Z. and Zhang, X. and Dong, W. and Wang, X. and He, S. and Zhang, H. and Wei, R. and others},
  title   = {{TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling}},
  journal = {PLoS pathogens},
  year    = {2020},
  doi     = {10.1371/journal.ppat.1008543},
  pmid    = {32401783},
  url     = {https://doi.org/10.1371/journal.ppat.1008543}
}

@article{han2022-36041498,
  author  = {Han, X. and Cheng, X. and Xu, J. and Liu, Y. and Zhou, J. and Jiang, L. and Gu, X. and Xia, T.},
  title   = {{Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice}},
  journal = {Neuropharmacology},
  year    = {2022},
  doi     = {10.1016/j.neuropharm.2022.109231},
  pmid    = {36041498},
  url     = {https://doi.org/10.1016/j.neuropharm.2022.109231}
}

@article{liu2019-31477129,
  author  = {Liu, C. and Li, P. and Li, H. and Wang, S. and Ding, L. and Wang, H. and Ye, H. and Jin, Y. and others},
  title   = {{TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding}},
  journal = {Journal of translational medicine},
  year    = {2019},
  doi     = {10.1186/s12967-019-2050-9},
  pmid    = {31477129},
  url     = {https://doi.org/10.1186/s12967-019-2050-9}
}

@article{luo2023-37003186,
  author  = {Luo, Q. and Deng, D. and Li, Y. and Shi, H. and Zhao, J. and Qian, Q. and Wang, W. and Cai, J. and others},
  title   = {{TREM2 Insufficiency Protects against Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization}},
  journal = {International immunopharmacology},
  year    = {2023},
  doi     = {10.1016/j.intimp.2023.110070},
  pmid    = {37003186},
  url     = {https://doi.org/10.1016/j.intimp.2023.110070}
}

@article{hallroberts2020-33198789,
  author  = {Hall-Roberts, H. and Agarwal, D. and Obst, J. and Smith, T. B. and Monzón-Sandoval, J. and Di Daniel, E. and Webber, C. and James, W. S. and others},
  title   = {{TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00709-z},
  pmid    = {33198789},
  url     = {https://doi.org/10.1186/s13195-020-00709-z}
}

@article{dabla2022-35924849,
  author  = {Dabla, A. and Liang, Y. C. and Rajabalee, N. and Irwin, C. and Moonen, C. G. J. and Willis, J. V. and Berton, S. and Sun, J.},
  title   = {{TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages}},
  journal = {mBio},
  year    = {2022},
  doi     = {10.1128/mbio.01456-22},
  pmid    = {35924849},
  url     = {https://doi.org/10.1128/mbio.01456-22}
}

@article{jantti2022-35706029,
  author  = {Jäntti, H. and Sitnikova, V. and Ishchenko, Y. and Shakirzyanova, A. and Giudice, L. and Ugidos, I. F. and Gómez-Budia, M. and Korvenlaita, N. and others},
  title   = {{Microglial amyloid beta clearance is driven by PIEZO1 channels}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02486-y},
  pmid    = {35706029},
  url     = {https://doi.org/10.1186/s12974-022-02486-y}
}

@article{venegas2017-29293211,
  author  = {Venegas, C. and Kumar, S. and Franklin, B. S. and Dierkes, T. and Brinkschulte, R. and Tejera, D. and Vieira-Saecker, A. and Schwartz, S. and others},
  title   = {{Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease}},
  journal = {Nature},
  year    = {2017},
  doi     = {10.1038/nature25158},
  pmid    = {29293211},
  url     = {https://doi.org/10.1038/nature25158}
}

@article{muzio2021-34630027,
  author  = {Muzio, L. and Viotti, A. and Martino, G.},
  title   = {{Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy}},
  journal = {Frontiers in neuroscience},
  year    = {2021},
  doi     = {10.3389/fnins.2021.742065},
  pmid    = {34630027},
  url     = {https://doi.org/10.3389/fnins.2021.742065}
}

@article{wendimu2022-35805174,
  author  = {Wendimu, M. Y. and Hooks, S. B.},
  title   = {{Microglia Phenotypes in Aging and Neurodegenerative Diseases}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11132091},
  pmid    = {35805174},
  url     = {https://doi.org/10.3390/cells11132091}
}

@article{lier2021-34571885,
  author  = {Lier, J. and Streit, W. J. and Bechmann, I.},
  title   = {{Beyond Activation: Characterizing Microglial Functional Phenotypes}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10092236},
  pmid    = {34571885},
  url     = {https://doi.org/10.3390/cells10092236}
}

@article{cornell2022-34472455,
  author  = {Cornell, J. and Salinas, S. and Huang, H. Y. and Zhou, M.},
  title   = {{Microglia regulation of synaptic plasticity and learning and memory}},
  journal = {Neural regeneration research},
  year    = {2022},
  doi     = {10.4103/1673-5374.322423},
  pmid    = {34472455},
  url     = {https://doi.org/10.4103/1673-5374.322423}
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@article{xie2021-35069578,
  author  = {Xie, J. and Van Hoecke, L. and Vandenbroucke, R. E.},
  title   = {{The Impact of Systemic Inflammation on Alzheimer's Disease Pathology}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.796867},
  pmid    = {35069578},
  url     = {https://doi.org/10.3389/fimmu.2021.796867}
}

@article{daniels2016-27509875,
  author  = {Daniels, M. J. and Rivers-Auty, J. and Schilling, T. and Spencer, N. G. and Watremez, W. and Fasolino, V. and Booth, S. J. and White, C. S. and others},
  title   = {{Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models}},
  journal = {Nature communications},
  year    = {2016},
  doi     = {10.1038/ncomms12504},
  pmid    = {27509875},
  url     = {https://doi.org/10.1038/ncomms12504}
}

@article{salter2017-28886007,
  author  = {Salter, M. W. and Stevens, B.},
  title   = {{Microglia emerge as central players in brain disease}},
  journal = {Nature medicine},
  year    = {2017},
  doi     = {10.1038/nm.4397},
  pmid    = {28886007},
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@article{zhang2023-37433768,
  author  = {Zhang, W. and Xiao, D. and Mao, Q. and Xia, H.},
  title   = {{Role of neuroinflammation in neurodegeneration development}},
  journal = {Signal transduction and targeted therapy},
  year    = {2023},
  doi     = {10.1038/s41392-023-01486-5},
  pmid    = {37433768},
  url     = {https://doi.org/10.1038/s41392-023-01486-5}
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@article{guo2022-35250543,
  author  = {Guo, S. and Wang, H. and Yin, Y.},
  title   = {{Microglia Polarization From M1 to M2 in Neurodegenerative Diseases}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.815347},
  pmid    = {35250543},
  url     = {https://doi.org/10.3389/fnagi.2022.815347}
}

@article{rajesh2022-35741014,
  author  = {Rajesh, Y. and Kanneganti, T. D.},
  title   = {{Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11121885},
  pmid    = {35741014},
  url     = {https://doi.org/10.3390/cells11121885}
}

@article{yang2022-36353359,
  author  = {Yang, J. and Ran, M. and Li, H. and Lin, Y. and Ma, K. and Yang, Y. and Fu, X. and Yang, S.},
  title   = {{New insight into neurological degeneration: Inflammatory cytokines and blood-brain barrier}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2022},
  doi     = {10.3389/fnmol.2022.1013933},
  pmid    = {36353359},
  url     = {https://doi.org/10.3389/fnmol.2022.1013933}
}

@article{qi2025-41168805,
  author  = {Qi, Xiaoshan and Zhu, Kedong and Ke, Wei and Wang, Junjie and Mao, Shanping and Chen, Guiqin},
  title   = {{Roles of TREM2 in Alzheimer's disease}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00515-3},
  pmid    = {41168805},
  url     = {https://doi.org/10.1186/s40035-025-00515-3}
}

@article{peng2025-41261263,
  author  = {Peng, Xiao-Qian and Yang, Zi-Kang and Guo, Hong-Song and Wu, Xiang-Yuan and Ruganzu, John Bosco and Liu, Zhong-Zhong and Wu, Song-Di and Yang, Wei-Na},
  title   = {{TREM2 Alleviates Neuroinflammation and Improves Neurogenesis in ApoE-/- Mice by Regulating M1/M2 Microglial Polarization}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-05449-5},
  pmid    = {41261263},
  url     = {https://doi.org/10.1007/s12035-025-05449-5}
}

@article{olejnik2025-40405515,
  author  = {Olejnik, Beata and Ferens-Sieczkowska, Mirosława},
  title   = {{Lectins and neurodegeneration: A glycobiologist's perspective}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2025},
  doi     = {10.17219/acem/204107},
  pmid    = {40405515},
  url     = {https://doi.org/10.17219/acem/204107}
}

@article{shojaei2024-39431020,
  author  = {Shojaei, Monireh and Schaefer, Rebecca and Schlepckow, Kai and Kunze, Lea H and Struebing, Felix L and Brunner, Bettina and Willem, Michael and Bartos, Laura M and others},
  title   = {{PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies}},
  journal = {Theranostics},
  year    = {2024},
  doi     = {10.7150/thno.97149},
  pmid    = {39431020},
  url     = {https://doi.org/10.7150/thno.97149}
}

@article{bosco2025-39353548,
  author  = {Bosco, Dale B and Kremen, Vaclav and Haruwaka, Koichiro and Zhao, Shunyi and Wang, Lingxiao and Ebner, Blake A and Zheng, Jiaying and Xie, Manling and others},
  title   = {{Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus}},
  journal = {Brain, behavior, and immunity},
  year    = {2025},
  doi     = {10.1016/j.bbi.2024.09.034},
  pmid    = {39353548},
  url     = {https://doi.org/10.1016/j.bbi.2024.09.034}
}

@article{chen2025-40305572,
  author  = {Chen, Dadian and Wang, Chen and Chen, Xi and Li, Jiayu and Chen, Shuai and Li, Yanzhong and Ma, Fangling and Li, Tingting and others},
  title   = {{Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders}},
  journal = {Science translational medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.ads6111},
  pmid    = {40305572},
  url     = {https://doi.org/10.1126/scitranslmed.ads6111}
}

@article{chiang2024-38592304,
  author  = {Chiang, Yi-Kuan and Lin, Yung-Shuan and Chen, Chun-Yu and Lirng, Jiing-Feng and Yang, Yu-Hsiu and Lee, Wei-Ju and Fuh, Jong-Ling},
  title   = {{Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2024},
  doi     = {10.1177/15333175241243183},
  pmid    = {38592304},
  url     = {https://doi.org/10.1177/15333175241243183}
}

@article{cho2025-41337883,
  author  = {Cho, Sungwoo and El Gaamouch, Farida and Upadhyay, Saurabh and Nada, Hossam and Kuncewicz, Katarzyna and Gabr, Moustafa T},
  title   = {{As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2025},
  doi     = {10.1016/j.biopha.2025.118862},
  pmid    = {41337883},
  url     = {https://doi.org/10.1016/j.biopha.2025.118862}
}

@article{gallo2025-41390810,
  author  = {Gallo, Carmela and Verrillo, Lucia and Manzo, Emiliano and Cauzzi, Emma and La Barbera, Livia and Sabatino, Giuseppina and De Paolis, Maria Luisa and Sciacca, Michele Francesco Maria and others},
  title   = {{Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03634-w},
  pmid    = {41390810},
  url     = {https://doi.org/10.1186/s12974-025-03634-w}
}

@article{ramakrishnan2024-38613944,
  author  = {Ramakrishnan, Gautham S and Berry, William L and Pacherille, Angela and Kerr, William G and Chisholm, John D and Pedicone, Chiara and Humphrey, Mary Beth},
  title   = {{SHIP inhibition mediates select TREM2-induced microglial functions}},
  journal = {Molecular immunology},
  year    = {2024},
  doi     = {10.1016/j.molimm.2024.04.002},
  pmid    = {38613944},
  url     = {https://doi.org/10.1016/j.molimm.2024.04.002}
}

@article{ferri2020-33768114,
  author  = {Ferri, Evelyn and Rossi, Paolo Dionigi and Geraci, Annalisa and Ciccone, Simona and Cesari, Matteo and Arosio, Beatrice},
  title   = {{The sTREM2 Concentrations in the Blood: A Marker of Neurodegeneration?}},
  journal = {Frontiers in molecular biosciences},
  year    = {2020},
  doi     = {10.3389/fmolb.2020.627931},
  pmid    = {33768114},
  url     = {https://doi.org/10.3389/fmolb.2020.627931}
}

@article{njoku2025-41009633,
  author  = {Njoku, George Chigozie and Kanmogne, Georgette Djuidje},
  title   = {{Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer's Disease and HIV-Associated Neurocognitive Disorders}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26189069},
  pmid    = {41009633},
  url     = {https://doi.org/10.3390/ijms26189069}
}

@article{yin2024-38347225,
  author  = {Yin, Tao and Yesiltepe, Metin and D'Adamio, Luciano},
  title   = {{Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias}},
  journal = {EMBO reports},
  year    = {2024},
  doi     = {10.1038/s44319-024-00077-x},
  pmid    = {38347225},
  url     = {https://doi.org/10.1038/s44319-024-00077-x}
}

@article{chen2025-40122810,
  author  = {Chen, Kai and Li, Fuyao and Zhang, Shuwen and Chen, Yixing and Ikezu, Tadafumi C and Li, Zonghua and Martens, Yuka A and Qiao, Wenhui and others},
  title   = {{Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03420-8},
  pmid    = {40122810},
  url     = {https://doi.org/10.1186/s12974-025-03420-8}
}

@article{li2025-40940798,
  author  = {Li, Ling and Zheng, Xiaoxiao and Ma, Hongyue and Zhu, Mingxia and Li, Xiuli and Sun, Xiaodan and Feng, Xinhong},
  title   = {{TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14171387},
  pmid    = {40940798},
  url     = {https://doi.org/10.3390/cells14171387}
}

@article{zgorzynska2024-38244651,
  author  = {Zgorzynska, Emilia},
  title   = {{TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges}},
  journal = {Molecular and cellular neurosciences},
  year    = {2024},
  doi     = {10.1016/j.mcn.2024.103917},
  pmid    = {38244651},
  url     = {https://doi.org/10.1016/j.mcn.2024.103917}
}

@article{wang2024-38831312,
  author  = {Wang, Xueting and Xie, Yuqi and Fan, Xiaoyang and Wu, Xiaomei and Wang, Dan and Zhu, Li},
  title   = {{Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01489-6},
  pmid    = {38831312},
  url     = {https://doi.org/10.1186/s13195-024-01489-6}
}

@article{vandermeulen2024-38654375,
  author  = {Vandermeulen, Lina and Geric, Ivana and Fumagalli, Laura and Kreir, Mohamed and Lu, Ashley and Nonneman, Annelies and Premereur, Jessie and Wolfs, Leen and others},
  title   = {{Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-024-00725-9},
  pmid    = {38654375},
  url     = {https://doi.org/10.1186/s13024-024-00725-9}
}

@article{sun2024-39062547,
  author  = {Sun, Zhongqing and Zhang, Xin and So, Kwok-Fai and Jiang, Wen and Chiu, Kin},
  title   = {{Targeting Microglia in Alzheimer's Disease: Pathogenesis and Potential Therapeutic Strategies}},
  journal = {Biomolecules},
  year    = {2024},
  doi     = {10.3390/biom14070833},
  pmid    = {39062547},
  url     = {https://doi.org/10.3390/biom14070833}
}

@article{aldalahmah2024-38626772,
  author  = {Al-Dalahmah, Osama and Lam, Matti and McInvale, Julie J and Qu, Wenhui and Nguyen, Trang and Mun, Jeong-Yeon and Kwon, Sam and Ifediora, Nkechime and others},
  title   = {{Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons}},
  journal = {Cell stem cell},
  year    = {2024},
  doi     = {10.1016/j.stem.2024.03.013},
  pmid    = {38626772},
  url     = {https://doi.org/10.1016/j.stem.2024.03.013}
}

@article{cadiz2024-38226975,
  author  = {Cadiz, Mika P and Gibson, Katelin A and Todd, Kennedi T and Nascari, David G and Massa, Nashali and Lilley, Meredith T and Olney, Kimberly C and Al-Amin, Md Mamun and others},
  title   = {{Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231363},
  pmid    = {38226975},
  url     = {https://doi.org/10.1084/jem.20231363}
}

@article{butovsky2025-40324382,
  author  = {Butovsky, Oleg and Rosenzweig, Neta},
  title   = {{Alzheimer's disease and age-related macular degeneration: Shared and distinct immune mechanisms}},
  journal = {Immunity},
  year    = {2025},
  doi     = {10.1016/j.immuni.2025.04.013},
  pmid    = {40324382},
  url     = {https://doi.org/10.1016/j.immuni.2025.04.013}
}

@article{xu2025-40075143,
  author  = {Xu, Wen and Huang, Yi and Zhou, Rongbin},
  title   = {{NLRP3 inflammasome in neuroinflammation and central nervous system diseases}},
  journal = {Cellular \& molecular immunology},
  year    = {2025},
  doi     = {10.1038/s41423-025-01275-w},
  pmid    = {40075143},
  url     = {https://doi.org/10.1038/s41423-025-01275-w}
}

@article{li2025-40260242,
  author  = {Li, Zhitao and Gong, Chunrong},
  title   = {{NLRP3 inflammasome in Alzheimer's disease: molecular mechanisms and emerging therapies}},
  journal = {Frontiers in immunology},
  year    = {2025},
  doi     = {10.3389/fimmu.2025.1583886},
  pmid    = {40260242},
  url     = {https://doi.org/10.3389/fimmu.2025.1583886}
}

@article{verma2024-38507186,
  author  = {Verma, Ambika and Azhar, Gohar and Patyal, Pankaj and Zhang, Wei and Zhang, Xiaomin and Wei, Jeanne Y},
  title   = {{Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells}},
  journal = {GeroScience},
  year    = {2024},
  doi     = {10.1007/s11357-024-01117-z},
  pmid    = {38507186},
  url     = {https://doi.org/10.1007/s11357-024-01117-z}
}

@article{wang2025-40847374,
  author  = {Wang, Jie and Ni, Hong and Wang, Yu and Wei, Luyao and Ding, Hanqing and Guo, Zhongzhao and Pan, Hao and Yu, Ying and others},
  title   = {{Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00501-9},
  pmid    = {40847374},
  url     = {https://doi.org/10.1186/s40035-025-00501-9}
}

@article{guo2025-40541122,
  author  = {Guo, Minsong and Wang, Zhengqin and Zhou, Xiaogang and Yu, Chonglin and Wu, Jianming and Yu, Lu and Mi, Jianing and Ren, Fang and others},
  title   = {{Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.156928},
  pmid    = {40541122},
  url     = {https://doi.org/10.1016/j.phymed.2025.156928}
}

@article{vilella2024-37967665,
  author  = {Vilella, Antonietta and Bodria, Martina and Papotti, Bianca and Zanotti, Ilaria and Zimetti, Francesca and Remaggi, Giulia and Elviri, Lisa and Potì, Francesco and others},
  title   = {{PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2024},
  doi     = {10.1016/j.bbi.2023.11.008},
  pmid    = {37967665},
  url     = {https://doi.org/10.1016/j.bbi.2023.11.008}
}

@article{xu2025-41175591,
  author  = {Xu, Ziwei and Huang, Feijun and Wu, Zheming and Xu, Ke and Huang, Liping},
  title   = {{Syringin attenuates Alzheimer's disease-associated neuroinflammation by inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.157454},
  pmid    = {41175591},
  url     = {https://doi.org/10.1016/j.phymed.2025.157454}
}

@article{joshi2024-39215356,
  author  = {Joshi, Radhika and Brezani, Veronika and Mey, Gabrielle M and Guixé-Muntet, Sergi and Ortega-Ribera, Marti and Zhuang, Yuan and Zivny, Adam and Werneburg, Sebastian and others},
  title   = {{IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2024},
  doi     = {10.1186/s12974-024-03203-7},
  pmid    = {39215356},
  url     = {https://doi.org/10.1186/s12974-024-03203-7}
}

@article{li2024-38043010,
  author  = {Li, Yunfeng and Chen, Xiongjin and Zhou, Mulan and Feng, Sifan and Peng, Xiaoping and Wang, Yan},
  title   = {{Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-230273},
  pmid    = {38043010},
  url     = {https://doi.org/10.3233/jad-230273}
}

@article{ravichandran2025-41206011,
  author  = {Ravichandran, Kishore Aravind and Brosseron, Frederic and McManus, Róisín M and Ising, Christina and Görgen, Simon and Schmidt, Susanne V and Santarelli, Fracesco and Lee, Se Young and others},
  title   = {{Enhancing Tyro3 signaling ameliorates IL-1β production through STAT1 in Alzheimer's disease models}},
  journal = {Journal of leukocyte biology},
  year    = {2025},
  doi     = {10.1093/jleuko/qiaf157},
  pmid    = {41206011},
  url     = {https://doi.org/10.1093/jleuko/qiaf157}
}

@article{han2025-40400619,
  author  = {Han, Jialin and Zhang, Zhi and Zhang, Pengfei and Yu, Qian and Cheng, Qian and Lu, Zhiming and Zong, Shuai},
  title   = {{The roles of microglia and astrocytes in neuroinflammation of Alzheimer's disease}},
  journal = {Frontiers in neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1575453},
  pmid    = {40400619},
  url     = {https://doi.org/10.3389/fnins.2025.1575453}
}

@article{serradas2024-39272998,
  author  = {Serradas, Maria L and Ding, Yingying and Martorell, Paula V and Kulińska, Ida and Castro-Gomez, Sergio},
  title   = {{Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease}},
  journal = {Cells},
  year    = {2024},
  doi     = {10.3390/cells13171426},
  pmid    = {39272998},
  url     = {https://doi.org/10.3390/cells13171426}
}

@article{braatz2024-36799439,
  author  = {Braatz, Charlotte and Komes, Max P and Ravichandran, Kishore Aravind and de Fragas, Matheus Garcia and Griep, Angelika and Schwartz, Stephanie and McManus, Róisín M and Heneka, Michael T},
  title   = {{NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro}},
  journal = {Journal of neurochemistry},
  year    = {2024},
  doi     = {10.1111/jnc.15778},
  pmid    = {36799439},
  url     = {https://doi.org/10.1111/jnc.15778}
}

@article{wang2025-41062518,
  author  = {Wang, Xiaoxuan and Tian, Haozhe and Chen, Shifei and Ying, Liangliang and Zheng, Juan and Song, Yaya and Xi, Jin and Zhang, Yuxin and others},
  title   = {{Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells}},
  journal = {Scientific reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-19015-5},
  pmid    = {41062518},
  url     = {https://doi.org/10.1038/s41598-025-19015-5}
}

@article{cai2025-39945772,
  author  = {Cai, Zhangying and Wang, Shoutang and Cao, Siyan and Chen, Yun and Penati, Silvia and Peng, Vincent and Yuede, Carla M and Beatty, Wandy L and others},
  title   = {{Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control}},
  journal = {The Journal of experimental medicine},
  year    = {2025},
  doi     = {10.1084/jem.20230173},
  pmid    = {39945772},
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@article{maphis2015-25833819,
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  title   = {{Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain}},
  journal = {Brain},
  year    = {2015},
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  title   = {{Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a}},
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@article{zhou2019-30756214,
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@article{yin2016-27717139,
  author  = {Yin, J. and Liu, X. and He, Q. and Zhou, L. and Yuan, Z. and Zhao, S.},
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  year    = {2016},
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  pmid    = {27717139},
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@article{taylor2020-32711525,
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  title   = {{A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01900-7},
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@article{miyashita2014-24762945,
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  title   = {{Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population}},
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  year    = {2014},
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@article{sheng2019-31219699,
  author  = {Sheng, L. and Chen, M. and Cai, K. and Song, Y. and Yu, D. and Zhang, H. and Xu, G.},
  title   = {{Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
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@article{tang2019-30683932,
  author  = {Tang, W. and Lv, B. and Yang, B. and Chen, Y. and Yuan, F. and Ma, L. and Chen, S. and Zhang, S. and others},
  title   = {{TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway}},
  journal = {Oncogenesis},
  year    = {2019},
  doi     = {10.1038/s41389-018-0115-x},
  pmid    = {30683932},
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@article{wu2022-35224156,
  author  = {Wu, M. and Liao, M. and Huang, R. and Chen, C. and Tian, T. and Wang, H. and Li, J. and others},
  title   = {{Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia}},
  journal = {Genes \& diseases},
  year    = {2022},
  doi     = {10.1016/j.gendis.2020.05.005},
  pmid    = {35224156},
  url     = {https://doi.org/10.1016/j.gendis.2020.05.005}
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@article{he2022-36316319,
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  title   = {{Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice}},
  journal = {Translational psychiatry},
  year    = {2022},
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  pmid    = {36316319},
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@article{casati2018-29377401,
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  title   = {{Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease}},
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  year    = {2018},
  doi     = {10.1111/ene.13583},
  pmid    = {29377401},
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@article{akhter2021-33461764,
  author  = {Akhter, R. and Shao, Y. and Formica, S. and Khrestian, M. and Bekris, L. M.},
  title   = {{TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells}},
  journal = {Molecular immunology},
  year    = {2021},
  doi     = {10.1016/j.molimm.2020.12.035},
  pmid    = {33461764},
  url     = {https://doi.org/10.1016/j.molimm.2020.12.035}
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@article{gervois2019-31379859,
  author  = {Gervois, P. and Lambrichts, I.},
  title   = {{The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke}},
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  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00436-5},
  pmid    = {33823896},
  url     = {https://doi.org/10.1186/s13024-021-00436-5}
}

@article{wolf2022-36119485,
  author  = {Wolf, Elysa M and Fingleton, Barbara and Hasty, Alyssa H},
  title   = {{The therapeutic potential of TREM2 in cancer}},
  journal = {Frontiers in oncology},
  year    = {2022},
  doi     = {10.3389/fonc.2022.984193},
  pmid    = {36119485},
  url     = {https://doi.org/10.3389/fonc.2022.984193}
}

@article{ibach2021-33314333,
  author  = {Ibach, Melanie and Mathews, Mona and Linnartz-Gerlach, Bettina and Theil, Sandra and Kumar, Sathish and Feederle, Regina and Brüstle, Oliver and Neumann, Harald and others},
  title   = {{A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.23953},
  pmid    = {33314333},
  url     = {https://doi.org/10.1002/glia.23953}
}

@article{joshi2021-34427354,
  author  = {Joshi, Pranav and Riffel, Florian and Satoh, Kanayo and Enomoto, Masahiro and Qamar, Seema and Scheiblich, Hannah and Villacampa, Nàdia and Kumar, Sathish and others},
  title   = {{Differential interaction with TREM2 modulates microglial uptake of modified Aβ species}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.24077},
  pmid    = {34427354},
  url     = {https://doi.org/10.1002/glia.24077}
}

@article{xue2021-33557250,
  author  = {Xue, Feng and Du, Heng},
  title   = {{TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10020321},
  pmid    = {33557250},
  url     = {https://doi.org/10.3390/cells10020321}
}

@article{biundo2023-37626591,
  author  = {Biundo, Fabrizio and Chitu, Violeta and Gökhan, Şölen and Chen, Edward and Oppong-Asare, Jude and Stanley, E Richard},
  title   = {{Trem2 Enhances Demyelination in the Csf1r+/- Mouse Model of Leukoencephalopathy}},
  journal = {Biomedicines},
  year    = {2023},
  doi     = {10.3390/biomedicines11082094},
  pmid    = {37626591},
  url     = {https://doi.org/10.3390/biomedicines11082094}
}

@article{vanderende2021-33896652,
  author  = {van der Ende, Emma L and Morenas-Rodriguez, Estrella and McMillan, Corey and Grossman, Murray and Irwin, David and Sanchez-Valle, Raquel and Graff, Caroline and Vandenberghe, Rik and others},
  title   = {{CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2021.02.024},
  pmid    = {33896652},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2021.02.024}
}

@article{boudesco2022-35912412,
  author  = {Boudesco, Christophe and Nonneman, Annelies and Cinti, Alessandro and Picardi, Paola and Redaelli, Loredana and Swijsen, Sofie and Roewe, Julian and Reinhardt, Peter and others},
  title   = {{Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells}},
  journal = {Glia},
  year    = {2022},
  doi     = {10.1002/glia.24252},
  pmid    = {35912412},
  url     = {https://doi.org/10.1002/glia.24252}
}

@article{degea2023-38162003,
  author  = {de Gea, Priscille and Benkeder, Sarah and Bouvet, Pauline and Aimard, Mélanie and Chounlamountri, Naura and Honnorat, Jérôme and Do, Le Duy and Meissirel, Claire},
  title   = {{VEGF controls microglial phagocytic response to amyloid-β}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2023},
  doi     = {10.3389/fncel.2023.1264402},
  pmid    = {38162003},
  url     = {https://doi.org/10.3389/fncel.2023.1264402}
}

@article{qu2023-34470515,
  author  = {Qu, Wenhui and Li, Ling},
  title   = {{Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2023},
  doi     = {10.1177/10738584211040786},
  pmid    = {34470515},
  url     = {https://doi.org/10.1177/10738584211040786}
}

@article{zhang2023-37926352,
  author  = {Zhang, Xin and Chen, Xue and Zhang, Ling and Sun, Yuqing and Liang, Ying and Li, Huan and Zhang, Yulin},
  title   = {{Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia}},
  journal = {Neurochemistry international},
  year    = {2023},
  doi     = {10.1016/j.neuint.2023.105639},
  pmid    = {37926352},
  url     = {https://doi.org/10.1016/j.neuint.2023.105639}
}

@article{koh2021-34884940,
  author  = {Koh, Han Seok and Lee, SangJoon and Lee, Hyo Jin and Min, Jae-Woong and Iwatsubo, Takeshi and Teunissen, Charlotte E and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222313136},
  pmid    = {34884940},
  url     = {https://doi.org/10.3390/ijms222313136}
}