% alzhub.org library filter % Source: https://alzhub.org/research?category=genetics&atag=apolipoprotein % 500 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{jansen2015-25988462, author = {Jansen, W. J. and Ossenkoppele, R. and Knol, D. L. and Tijms, B. M. and Scheltens, P. and Verhey, F. R. and Visser, P. J. and {Amyloid Biomarker Study Group} and others}, title = {{Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis}}, journal = {JAMA}, year = {2015}, doi = {10.1001/jama.2015.4668}, pmid = {25988462}, url = {https://doi.org/10.1001/jama.2015.4668} } @article{belloy2023-37930705, author = {Belloy, M. E. and Andrews, S. J. and Le Guen, Y. and Cuccaro, M. and Farrer, L. A. and Napolioni, V. and Greicius, M. D.}, title = {{APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry}}, journal = {JAMA Neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3599}, pmid = {37930705}, url = {https://doi.org/10.1001/jamaneurol.2023.3599} } @article{naj2011-21460841, author = {Naj, A. C. and Jun, G. and Beecham, G. W. and Wang, L. S. and Vardarajan, B. N. and Buros, J. and Gallins, P. J. and Buxbaum, J. D. and others}, title = {{Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease}}, journal = {Nature genetics}, year = {2011}, doi = {10.1038/ng.801}, pmid = {21460841}, url = {https://doi.org/10.1038/ng.801} } @article{garatachea2015-975b7ad3, author = {Garatachea, Nuria and Marín, Pedro J. and Santos-Lozano, Alejandro and Sanchis-Gomar, Fabian and Emanuele, Enzo and Lucia, Alejandro}, title = {{The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis}}, journal = {Rejuvenation Research}, year = {2015}, doi = {10.1089/rej.2014.1605}, url = {https://doi.org/10.1089/rej.2014.1605} } @article{seshadri2010-20460622, author = {Seshadri, S. and Fitzpatrick, A. L. and Ikram, M. A. and DeStefano, A. L. and Gudnason, V. and Boada, M. and Bis, J. C. and Smith, A. V. and others}, title = {{Genome-wide analysis of genetic loci associated with Alzheimer disease}}, journal = {JAMA}, year = {2010}, doi = {10.1001/jama.2010.574}, pmid = {20460622}, url = {https://doi.org/10.1001/jama.2010.574} } @article{reitz2013-23571587, author = {Reitz, C. and Jun, G. and Naj, A. and Rajbhandary, R. and Vardarajan, B. N. and Wang, L. S. and Valladares, O. and Lin, C. F. and others}, title = {{Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans}}, journal = {JAMA}, year = {2013}, doi = {10.1001/jama.2013.2973}, pmid = {23571587}, url = {https://doi.org/10.1001/jama.2013.2973} } @article{kunkle2021-33074286, author = {Kunkle, B. W. and Schmidt, M. and Klein, H. U. and Naj, A. C. and Hamilton-Nelson, K. L. and Larson, E. B. and Evans, D. A. and De Jager, P. L. and others}, title = {{Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis}}, journal = {JAMA neurology}, year = {2021}, doi = {10.1001/jamaneurol.2020.3536}, pmid = {33074286}, url = {https://doi.org/10.1001/jamaneurol.2020.3536} } @article{bergeron2018-30255971, author = {Bergeron, D. and Gorno-Tempini, M. L. and Rabinovici, G. D. and Santos-Santos, M. A. and Seeley, W. and Miller, B. L. and Pijnenburg, Y. and Keulen, M. A. and others}, title = {{Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia}}, journal = {Annals of neurology}, year = {2018}, doi = {10.1002/ana.25333}, pmid = {30255971}, url = {https://doi.org/10.1002/ana.25333} } @article{altmann2014-24623176, author = {Altmann, A. and Tian, L. and Henderson, V. W. and Greicius, M. D. and {Alzheimer's Disease Neuroimaging Initiative Investigators}}, title = {{Sex modifies the APOE-related risk of developing Alzheimer disease}}, journal = {Annals of neurology}, year = {2014}, doi = {10.1002/ana.24135}, pmid = {24623176}, url = {https://doi.org/10.1002/ana.24135} } @article{neu2017-28846757, author = {Neu, S. C. and Pa, J. and Kukull, W. and Beekly, D. and Kuzma, A. and Gangadharan, P. and Wang, L. S. and Romero, K. and others}, title = {{Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.2188}, pmid = {28846757}, url = {https://doi.org/10.1001/jamaneurol.2017.2188} } @article{serranopozo2021-33340485, author = {Serrano-Pozo, A. and Das, S. and Hyman, B. T.}, title = {{APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches}}, journal = {The Lancet. Neurology}, year = {2021}, doi = {10.1016/s1474-4422(20)30412-9}, pmid = {33340485}, url = {https://doi.org/10.1016/s1474-4422(20)30412-9} } @article{leguen2023-36809323, author = {Le Guen, Y. and Raulin, A. C. and Logue, M. W. and Sherva, R. and Belloy, M. E. and Eger, S. J. and Chen, A. and Kennedy, G. and Kuchenbecker, L. and O'Leary, J. P. and Zhang, R. and Merritt, V. C. and others}, title = {{Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease}}, journal = {JAMA}, year = {2023}, doi = {10.1001/jama.2023.0268}, pmid = {36809323}, url = {https://doi.org/10.1001/jama.2023.0268} } @article{quiroz2024-38899694, author = {Quiroz, Y. T. and Aguillon, D. and Aguirre-Acevedo, D. C. and Vasquez, D. and Zuluaga, Y. and Baena, A. Y. and Madrigal, L. and Hincapié, L. and Sanchez, J. S. and Langella, S. and Posada-Duque, R. and Littau, J. L. and others}, title = {{APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease}}, journal = {New England Journal of Medicine}, year = {2024}, doi = {10.1056/NEJMoa2308583}, pmid = {38899694}, url = {https://doi.org/10.1056/NEJMoa2308583} } @article{bhattarai2024-38598053, author = {Bhattarai, P. and Gunasekaran, T. I. and Belloy, M. E. and Reyes-Dumeyer, D. and Jülich, D. and Tayran, H. and Yilmaz, E. and Flaherty, D. and Turgutalp, B. and Sukumar, G. and Alba, C. and McGrath, E. M. and others}, title = {{Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease}}, journal = {Acta Neuropathologica}, year = {2024}, doi = {10.1007/s00401-024-02721-1}, pmid = {38598053}, url = {https://doi.org/10.1007/s00401-024-02721-1} } @article{chapuis2013-23399914, author = {Chapuis, J. and Hansmannel, F. and Gistelinck, M. and Mounier, A. and Van Cauwenberghe, C. and Kolen, K. V. and Geller, F. and Sottejeau, Y. and others}, title = {{Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology}}, journal = {Molecular psychiatry}, year = {2013}, doi = {10.1038/mp.2013.1}, pmid = {23399914}, url = {https://doi.org/10.1038/mp.2013.1} } @article{naj2014-25199842, author = {Naj, A. C. and Jun, G. and Reitz, C. and Kunkle, B. W. and Perry, W. and Park, Y. S. and Beecham, G. W. and Rajbhandary, R. A. and others}, title = {{Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.1491}, pmid = {25199842}, url = {https://doi.org/10.1001/jamaneurol.2014.1491} } @article{farrer1997-9343467, author = {Farrer, L. A. and Cupples, L. A. and Haines, J. L. and Hyman, B. and Kukull, W. A. and Mayeux, R. and Myers, R. H. and Pericak-Vance, M. A. and others}, title = {{Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium}}, journal = {JAMA}, year = {1997}, doi = {10.1001/jama.1997.03550160069041}, pmid = {9343467}, url = {https://doi.org/10.1001/jama.1997.03550160069041} } @article{tang1998-9508150, author = {Tang, M. X. and Stern, Y. and Marder, K. and Bell, K. and Gurland, B. and Lantigua, R. and Andrews, H. and Feng, L. and others}, title = {{The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics}}, journal = {JAMA}, year = {1998}, doi = {10.1001/jama.279.10.751}, pmid = {9508150}, url = {https://doi.org/10.1001/jama.279.10.751} } @article{tsuang2013-23407718, author = {Tsuang, D. and Leverenz, J. B. and Lopez, O. L. and Hamilton, R. L. and Bennett, D. A. and Schneider, J. A. and Buchman, A. S. and Larson, E. B. and others}, title = {{APOE ε4 increases risk for dementia in pure synucleinopathies}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.600}, pmid = {23407718}, url = {https://doi.org/10.1001/jamaneurol.2013.600} } @article{slooter1998-9678314, author = {Slooter, A. J. and Cruts, M. and Kalmijn, S. and Hofman, A. and Breteler, M. M. and Van Broeckhoven, C. and van Duijn, C. M.}, title = {{Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study}}, journal = {Archives of neurology}, year = {1998}, doi = {10.1001/archneur.55.7.964}, pmid = {9678314}, url = {https://doi.org/10.1001/archneur.55.7.964} } @article{miyashita2013-23565137, author = {Miyashita, A. and Koike, A. and Jun, G. and Wang, L. S. and Takahashi, S. and Matsubara, E. and Kawarabayashi, T. and Shoji, M. and others}, title = {{SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians}}, journal = {PloS one}, year = {2013}, doi = {10.1371/journal.pone.0058618}, pmid = {23565137}, url = {https://doi.org/10.1371/journal.pone.0058618} } @article{chauhan2015-25670335, author = {Chauhan, G. and Adams, H. H. H. and Bis, J. C. and Weinstein, G. and Yu, L. and Töglhofer, A. M. and Smith, A. V. and van der Lee, S. J. and others}, title = {{Association of Alzheimer's disease GWAS loci with MRI markers of brain aging}}, journal = {Neurobiology of aging}, year = {2015}, doi = {10.1016/j.neurobiolaging.2014.12.028}, pmid = {25670335}, url = {https://doi.org/10.1016/j.neurobiolaging.2014.12.028} } @article{yu2015-25365775, author = {Yu, L. and Chibnik, L. B. and Srivastava, G. P. and Pochet, N. and Yang, J. and Xu, J. and Kozubek, J. and Obholzer, N. and others}, title = {{Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2014.3049}, pmid = {25365775}, url = {https://doi.org/10.1001/jamaneurol.2014.3049} } @article{ganguli2000-10867779, author = {Ganguli, M. and Chandra, V. and Kamboh, M. I. and Johnston, J. M. and Dodge, H. H. and Thelma, B. K. and Juyal, R. C. and Pandav, R. and others}, title = {{Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study}}, journal = {Archives of neurology}, year = {2000}, doi = {10.1001/archneur.57.6.824}, pmid = {10867779}, url = {https://doi.org/10.1001/archneur.57.6.824} } @article{bettens2012-22248099, author = {Bettens, K. and Brouwers, N. and Engelborghs, S. and Lambert, J. C. and Rogaeva, E. and Vandenberghe, R. and Le Bastard, N. and Pasquier, F. and others}, title = {{Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk}}, journal = {Molecular neurodegeneration}, year = {2012}, doi = {10.1186/1750-1326-7-3}, pmid = {22248099}, url = {https://doi.org/10.1186/1750-1326-7-3} } @article{antolini2021-34531298, author = {Antolini, L. and DiFrancesco, J. C. and Zedde, M. and Basso, G. and Arighi, A. and Shima, A. and Cagnin, A. and Caulo, M. and others}, title = {{Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012778}, pmid = {34531298}, url = {https://doi.org/10.1212/wnl.0000000000012778} } @article{hanson2013-23779114, author = {Hanson, A. J. and Bayer-Carter, J. L. and Green, P. S. and Montine, T. J. and Wilkinson, C. W. and Baker, L. D. and Watson, G. S. and Bonner, L. M. and others}, title = {{Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.396}, pmid = {23779114}, url = {https://doi.org/10.1001/jamaneurol.2013.396} } @article{leguen2022-35639372, author = {Le Guen, Y. and Belloy, M. E. and Grenier-Boley, B. and de Rojas, I. and Castillo-Morales, A. and Jansen, I. and Nicolas, A. and Bellenguez, C. and others}, title = {{Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.1166}, pmid = {35639372}, url = {https://doi.org/10.1001/jamaneurol.2022.1166} } @article{karanth2020-32568358, author = {Karanth, S. and Nelson, P. T. and Katsumata, Y. and Kryscio, R. J. and Schmitt, F. A. and Fardo, D. W. and Cykowski, M. D. and Jicha, G. A. and others}, title = {{Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.1741}, pmid = {32568358}, url = {https://doi.org/10.1001/jamaneurol.2020.1741} } @article{shinohara2020-685d61d2, author = {Shinohara, M. and Kanekiyo, T. and Tachibana, M. and Kurti, A. and Fu, Y. and Zhao, J. and Han, X. and Sullivan, P. M. and Rebeck, G. W. and Fryer, J. D. and Heckman, M. G. and Bu, G.}, title = {{APOE2 is associated with longevity independent of Alzheimer's disease}}, journal = {eLife}, year = {2020} } @article{small1995-7884953, author = {Small, G. W. and Mazziotta, J. C. and Collins, M. T. and Baxter, L. R. and Phelps, M. E. and Mandelkern, M. A. and Kaplan, A. and La Rue, A. and others}, title = {{Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease}}, journal = {JAMA}, year = {1995}, doi = {10.1001/jama.1995.03520360056039}, pmid = {7884953}, url = {https://doi.org/10.1001/jama.1995.03520360056039} } @article{schrijvers2010-21115952, author = {Schrijvers, E. M. and Witteman, J. C. and Sijbrands, E. J. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.}, title = {{Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181ffe4f6}, pmid = {21115952}, url = {https://doi.org/10.1212/wnl.0b013e3181ffe4f6} } @article{mormino2014-24748674, author = {Mormino, E. C. and Betensky, R. A. and Hedden, T. and Schultz, A. P. and Ward, A. and Huijbers, W. and Rentz, D. M. and Johnson, K. A. and others}, title = {{Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000431}, pmid = {24748674}, url = {https://doi.org/10.1212/wnl.0000000000000431} } @article{pietrzak2015-25629787, author = {Pietrzak, R. H. and Lim, Y. Y. and Neumeister, A. and Ames, D. and Ellis, K. A. and Harrington, K. and Lautenschlager, N. T. and Restrepo, C. and others}, title = {{Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study}}, journal = {JAMA psychiatry}, year = {2015}, doi = {10.1001/jamapsychiatry.2014.2476}, pmid = {25629787}, url = {https://doi.org/10.1001/jamapsychiatry.2014.2476} } @article{jin2021-34061824, author = {Jin, X. and He, W. and Zhang, Y. and Gong, E. and Niu, Z. and Ji, J. and Li, Y. and Zeng, Y. and others}, title = {{Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study}}, journal = {PLoS medicine}, year = {2021}, doi = {10.1371/journal.pmed.1003597}, pmid = {34061824}, url = {https://doi.org/10.1371/journal.pmed.1003597} } @article{morris2016-26836731, author = {Morris, M. C. and Brockman, J. and Schneider, J. A. and Wang, Y. and Bennett, D. A. and Tangney, C. C. and van de Rest, O.}, title = {{Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults}}, journal = {JAMA}, year = {2016}, doi = {10.1001/jama.2015.19451}, pmid = {26836731}, url = {https://doi.org/10.1001/jama.2015.19451} } @article{ray2025-40096060, author = {Ray, Nicholas R. and Bradley, Joseph L. and Yılmaz, Elanur and Kızıl, Çağhan and Kurup, Jiji Thulaseedhara and Martin, Eden R. and Klein, Hans‐Ulrich and Kunkle, Brian W. and others}, title = {{Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease}}, journal = {PLoS Genetics}, year = {2025}, doi = {10.1371/journal.pgen.1011631}, pmid = {40096060}, url = {https://doi.org/10.1371/journal.pgen.1011631} } @article{saunders1993-8350998, author = {Saunders, Ann M. and Strittmatter, Warren J. and Schmechel, D. E. and George‐Hyslop, Peter St and Vance, Jeffery M. and Joo, S. H. and Rosi, B.L. and Gusella, James F. and others}, title = {{Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease}}, journal = {Neurology}, year = {1993}, doi = {10.1212/wnl.43.8.1467}, pmid = {8350998}, url = {https://doi.org/10.1212/wnl.43.8.1467} } @article{barral2025-40219824, author = {Barral, S. and Yang, Z. and Phillips, N. and Barber, R. C. and Brickman, A. M. and Honig, L. S. and Cieza, B. and Reyes-Dumeyer, D. and Mayeux, R. and Rajabli, F. and others}, title = {{APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70138}, pmid = {40219824}, url = {https://doi.org/10.1002/alz.70138} } @article{kamagata2022-36123122, author = {Kamagata, K. and Andica, C. and Takabayashi, K. and Saito, Y. and Taoka, T. and Nozaki, H. and Kikuta, J. and Fujita, S. and others}, title = {{Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201300}, pmid = {36123122}, url = {https://doi.org/10.1212/wnl.0000000000201300} } @article{lim2013-24145819, author = {Lim, A. S. and Yu, L. and Kowgier, M. and Schneider, J. A. and Buchman, A. S. and Bennett, D. A.}, title = {{Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.4215}, pmid = {24145819}, url = {https://doi.org/10.1001/jamaneurol.2013.4215} } @article{brouwers2012-21403675, author = {Brouwers, N. and Van Cauwenberghe, C. and Engelborghs, S. and Lambert, J. C. and Bettens, K. and Le Bastard, N. and Pasquier, F. and Montoya, A. G. and others}, title = {{Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites}}, journal = {Molecular psychiatry}, year = {2012}, doi = {10.1038/mp.2011.24}, pmid = {21403675}, url = {https://doi.org/10.1038/mp.2011.24} } @article{ge2018-29592889, author = {Ge, T. and Sabuncu, M. R. and Smoller, J. W. and Sperling, R. A. and Mormino, E. C. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005415}, pmid = {29592889}, url = {https://doi.org/10.1212/wnl.0000000000005415} } @article{steele2017-28350795, author = {Steele, N. Z. and Carr, J. S. and Bonham, L. W. and Geier, E. G. and Damotte, V. and Miller, Z. A. and Desikan, R. S. and Boehme, K. L. and others}, title = {{Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study}}, journal = {PLoS medicine}, year = {2017}, doi = {10.1371/journal.pmed.1002272}, pmid = {28350795}, url = {https://doi.org/10.1371/journal.pmed.1002272} } @article{sherrington1995-7596406, author = {Sherrington, Robin P. and Rogaev, Evgeny Ivanovich and Liang, Yuh‐Jin and Rogaeva, Ekaterina A. and Lévesque, Georges and Ikeda, Masaki and Chi, H. and Lin, Chiao‐Feng and others}, title = {{Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease}}, journal = {Nature}, year = {1995}, doi = {10.1038/375754a0}, pmid = {7596406}, url = {https://doi.org/10.1038/375754a0} } @article{bertram2008-18802446, author = {Bertram, L. and Tanzi, R. E.}, title = {{Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses}}, journal = {Nature reviews. Neuroscience}, year = {2008}, doi = {10.1038/nrn2494}, pmid = {18802446}, url = {https://doi.org/10.1038/nrn2494} } @article{langbaum2025-41319675, author = {Langbaum, J. B. and Bradbury, A. R. and Egleston, B. L. and McCarty Wood, E. and Langlois, C. M. and Largent, E. A. and Harkins, K. and Erickson, C. M. and Stites, S. D. and Oyen, E. and others}, title = {{Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1}}, journal = {The Lancet Healthy Longevity}, year = {2025}, doi = {10.1016/j.lanhl.2025.100778}, pmid = {41319675}, url = {https://doi.org/10.1016/j.lanhl.2025.100778} } @article{raya2026-41729539, author = {Raya, Maison Abu and Suemoto, Claudia Kimie and Paes, Vitor Ribeiro and Leite, Renata Elaine Paraizo and Pasqualucci, Carlos Augusto and Naslavsky, Michel Satya and Rodriguez, Roberta Diehl and Nitrini, Ricardo and others}, title = {{Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample}}, journal = {JAMA neurology}, year = {2026}, doi = {10.1001/jamaneurol.2026.0054}, pmid = {41729539}, url = {https://doi.org/10.1001/jamaneurol.2026.0054} } @article{tao2018-30646251, author = {Tao, Q. and Ang, T. F. A. and DeCarli, C. and Auerbach, S. H. and Devine, S. and Stein, T. D. and Zhang, X. and Massaro, J. and others}, title = {{Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers}}, journal = {JAMA network open}, year = {2018}, doi = {10.1001/jamanetworkopen.2018.3597}, pmid = {30646251}, url = {https://doi.org/10.1001/jamanetworkopen.2018.3597} } @article{rajabli2018-30517106, author = {Rajabli, F. and Feliciano, B. E. and Celis, K. and Hamilton-Nelson, K. L. and Whitehead, P. L. and Adams, L. D. and Bussies, P. L. and Manrique, C. P. and others}, title = {{Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations}}, journal = {PLoS genetics}, year = {2018}, doi = {10.1371/journal.pgen.1007791}, pmid = {30517106}, url = {https://doi.org/10.1371/journal.pgen.1007791} } @article{desikan2015-25862742, author = {Desikan, R. S. and Schork, A. J. and Wang, Y. and Thompson, W. K. and Dehghan, A. and Ridker, P. M. and Chasman, D. I. and McEvoy, L. K. and others}, title = {{Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease}}, journal = {Circulation}, year = {2015}, doi = {10.1161/circulationaha.115.015489}, pmid = {25862742}, url = {https://doi.org/10.1161/circulationaha.115.015489} } @article{delcampo2016-26643548, author = {Del Campo, N. and Payoux, P. and Djilali, A. and Delrieu, J. and Hoogendijk, E. O. and Rolland, Y. and Cesari, M. and Weiner, M. W. and others}, title = {{Relationship of regional brain β-amyloid to gait speed}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000002235}, pmid = {26643548}, url = {https://doi.org/10.1212/wnl.0000000000002235} } @article{grill2026-41910973, author = {Grill, Joshua D. and RAMAN, REMA and Wang, Shunran and Ernstrom, Karin B. and Andrews, Patricia and Appleby, Brian Stephen and Bhangu, Jaspreet S. and Dhadda, Shobha and others}, title = {{Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.3845}, pmid = {41910973}, url = {https://doi.org/10.1001/jamanetworkopen.2026.3845} } @article{corder1993-8346443, author = {Corder, Elizabeth H. and Saunders, Ann M. and Strittmatter, Warren J. and Schmechel, D. E. and Gaskell, Perry C. and Small, Gary W. and Roses, Allen D. and Haines, J. L. and others}, title = {{Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families}}, journal = {Science}, year = {1993}, doi = {10.1126/science.8346443}, pmid = {8346443}, url = {https://doi.org/10.1126/science.8346443} } @article{goate1991-1671712, author = {Goate, Alison and Chartier‐Harlin, Marie‐Christine and Mullan, Mike and Brown, Jeremy and Crawford, Fiona and Fidani, Liana and Giuffra, Luis A. and Haynes, Andrew R. and others}, title = {{Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease}}, journal = {Nature}, year = {1991}, doi = {10.1038/349704a0}, pmid = {1671712}, url = {https://doi.org/10.1038/349704a0} } @article{morris2010-20186853, author = {Morris, J. C. and Roe, C. M. and Xiong, C. and Fagan, A. M. and Goate, A. M. and Holtzman, D. M. and Mintun, M. A.}, title = {{APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging}}, journal = {Annals of neurology}, year = {2010}, doi = {10.1002/ana.21843}, pmid = {20186853}, url = {https://doi.org/10.1002/ana.21843} } @article{li2008-17998437, author = {Li, H. and Wetten, S. and Li, L. and St Jean, P. L. and Upmanyu, R. and Surh, L. and Hosford, D. and Barnes, M. R. and others}, title = {{Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease}}, journal = {Archives of neurology}, year = {2008}, doi = {10.1001/archneurol.2007.3}, pmid = {17998437}, url = {https://doi.org/10.1001/archneurol.2007.3} } @article{gurol2006-16401840, author = {Gurol, M. E. and Irizarry, M. C. and Smith, E. E. and Raju, S. and Diaz-Arrastia, R. and Bottiglieri, T. and Rosand, J. and Growdon, J. H. and others}, title = {{Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000191403.95453.6a}, pmid = {16401840}, url = {https://doi.org/10.1212/01.wnl.0000191403.95453.6a} } @article{allen2012-22722634, author = {Allen, M. and Zou, F. and Chai, H. S. and Younkin, C. S. and Crook, J. and Pankratz, V. S. and Carrasquillo, M. M. and Rowley, C. N. and others}, title = {{Novel late-onset Alzheimer disease loci variants associate with brain gene expression}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182605801}, pmid = {22722634}, url = {https://doi.org/10.1212/wnl.0b013e3182605801} } @article{gupta2011-21422459, author = {Gupta, V. B. and Laws, S. M. and Villemagne, V. L. and Ames, D. and Bush, A. I. and Ellis, K. A. and Lui, J. K. and Masters, C. and others}, title = {{Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e318211c352}, pmid = {21422459}, url = {https://doi.org/10.1212/wnl.0b013e318211c352} } @article{huang2004-15210882, author = {Huang, X. and Chen, P. C. and Poole, C.}, title = {{APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000130159.28215.6a}, pmid = {15210882}, url = {https://doi.org/10.1212/01.wnl.0000130159.28215.6a} } @article{hall2006-16434658, author = {Hall, K. and Murrell, J. and Ogunniyi, A. and Deeg, M. and Baiyewu, O. and Gao, S. and Gureje, O. and Dickens, J. and others}, title = {{Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000194507.39504.17}, pmid = {16434658}, url = {https://doi.org/10.1212/01.wnl.0000194507.39504.17} } @article{mokry2016-27856775, author = {Mokry, L. E. and Ross, S. and Morris, J. A. and Manousaki, D. and Forgetta, V. and Richards, J. B.}, title = {{Genetically decreased vitamin D and risk of Alzheimer disease}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000003430}, pmid = {27856775}, url = {https://doi.org/10.1212/wnl.0000000000003430} } @article{proitsi2014-25226301, author = {Proitsi, P. and Lupton, M. K. and Velayudhan, L. and Newhouse, S. and Fogh, I. and Tsolaki, M. and Daniilidou, M. and Pritchard, M. and others}, title = {{Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis}}, journal = {PLoS medicine}, year = {2014}, doi = {10.1371/journal.pmed.1001713}, pmid = {25226301}, url = {https://doi.org/10.1371/journal.pmed.1001713} } @article{ringman2014-24797962, author = {Ringman, J. M. and Sachs, M. C. and Zhou, Y. and Monsell, S. E. and Saver, J. L. and Vinters, H. V.}, title = {{Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.681}, pmid = {24797962}, url = {https://doi.org/10.1001/jamaneurol.2014.681} } @article{fortea2024-3b742ebe, author = {Fortea, J. and Pegueroles, J. and Alcolea, D. and others}, title = {{APOE4 homozygosity represents a distinct genetic form of Alzheimer's disease}}, journal = {Nature Medicine}, year = {2024} } @article{dickson2018-30143564, author = {Dickson, D. W. and Heckman, M. G. and Murray, M. E. and Soto, A. I. and Walton, R. L. and Diehl, N. N. and van Gerpen, J. A. and Uitti, R. J. and others}, title = {{APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006212}, pmid = {30143564}, url = {https://doi.org/10.1212/wnl.0000000000006212} } @article{caselli2004-15184602, author = {Caselli, R. J. and Reiman, E. M. and Osborne, D. and Hentz, J. G. and Baxter, L. C. and Hernandez, J. L. and Alexander, G. G.}, title = {{Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000129533.26544.bf}, pmid = {15184602}, url = {https://doi.org/10.1212/01.wnl.0000129533.26544.bf} } @article{dufouil2005-15883313, author = {Dufouil, C. and Richard, F. and Fiévet, N. and Dartigues, J. F. and Ritchie, K. and Tzourio, C. and Amouyel, P. and Alpérovitch, A.}, title = {{APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: the Three-City Study}}, journal = {Neurology}, year = {2005}, doi = {10.1212/01.wnl.0000160114.42643.31}, pmid = {15883313}, url = {https://doi.org/10.1212/01.wnl.0000160114.42643.31} } @article{richardson2014-24473795, author = {Richardson, JR. and Roy, A. and Shalat, S. L. and von Stein, R. T. and Hossain, M. M. and Buckley, B. and Gearing, M. and Levey, A. I. and others}, title = {{Elevated serum pesticide levels and risk for Alzheimer disease}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2013.6030}, pmid = {24473795}, url = {https://doi.org/10.1001/jamaneurol.2013.6030} } @article{ronnemaa2008-18401020, author = {Rönnemaa, E. and Zethelius, B. and Sundelöf, J. and Sundström, J. and Degerman-Gunnarsson, M. and Berne, C. and Lannfelt, L. and Kilander, L.}, title = {{Impaired insulin secretion increases the risk of Alzheimer disease}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000310646.32212.3a}, pmid = {18401020}, url = {https://doi.org/10.1212/01.wnl.0000310646.32212.3a} } @article{bretsky1999-10609670, author = {Bretsky, P. M. and Buckwalter, J. G. and Seeman, T. E. and Miller, C. A. and Poirier, J. and Schellenberg, G. D. and Finch, C. E. and Henderson, V. W.}, title = {{Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease}}, journal = {Alzheimer disease and associated disorders}, year = {1999}, doi = {10.1097/00002093-199910000-00007}, pmid = {10609670}, url = {https://doi.org/10.1097/00002093-199910000-00007} } @article{yu2017-28108637, author = {Yu, L. and Lutz, M. W. and Wilson, R. S. and Burns, D. K. and Roses, A. D. and Saunders, A. M. and Gaiteri, C. and De Jager, P. L. and others}, title = {{TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000003614}, pmid = {28108637}, url = {https://doi.org/10.1212/wnl.0000000000003614} } @article{jackson2022-34957486, author = {Jackson, Rosemary J and Meltzer, Jonah C and Nguyen, Huong and Commins, Caitlin and Bennett, Rachel E and Hudry, Eloise and Hyman, Bradley T}, title = {{APOE4 derived from astrocytes leads to blood-brain barrier impairment}}, journal = {Brain : a journal of neurology}, year = {2022}, doi = {10.1093/brain/awab478}, pmid = {34957486}, url = {https://doi.org/10.1093/brain/awab478} } @article{brookhouser2021-33837271, author = {Brookhouser, Nicholas and Raman, Sreedevi and Frisch, Carlye and Srinivasan, Gayathri and Brafman, David A}, title = {{APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2021}, doi = {10.1038/s41380-021-01076-3}, pmid = {33837271}, url = {https://doi.org/10.1038/s41380-021-01076-3} } @article{liu2026-42799898, author = {Liu, Shengyi and Fan, Lingjie and He, Zihua and Yi, Tong and Wang, Jiaqi and Zhao, Junhan and Sander, Josemir W and Zhou, Dong and others}, title = {{Association of apolipoprotein E gene with risk, cognition, and prognosis of epilepsy}}, journal = {Human genetics}, year = {2026}, doi = {10.1007/s00439-026-02876-9}, pmid = {42799898}, url = {https://doi.org/10.1007/s00439-026-02876-9} } @article{coraglia2026-42169086, author = {Coraglia, Federico and Cecchetti, Giordano and Rugarli, Giulia and Spinelli, Edoardo G and Ghirelli, Alma and Pisano, Stefano and Canu, Elisa and Filippi, Massimo and others}, title = {{Plasma ApoE proteotyping for ApoE ε4 stratification in the anti-amyloid therapies era}}, journal = {Alzheimer's research \& therapy}, year = {2026}, doi = {10.1186/s13195-026-02089-2}, pmid = {42169086}, url = {https://doi.org/10.1186/s13195-026-02089-2} } @article{bradley2025-40556318, author = {Bradley, J. and Pottier, C. and da Fonseca, E. L. and Kurup, J. T. and Western, D. and Wang, C. and Neupane, A. and Ray, N. R. and Jean-Francois, M. and Ali, M. and Timsina, J. and Bergmann, K. and others}, title = {{Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70377}, pmid = {40556318}, url = {https://doi.org/10.1002/alz.70377} } @article{corder1994-7920638, author = {Corder, E. H. and Saunders, A. M. and Risch, N. J. and Strittmatter, W. J. and Schmechel, D. E. and Gaskell, P. C. and Rimmler, J. B. and Locke, P. A. and others}, title = {{Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease}}, journal = {Nature genetics}, year = {1994}, doi = {10.1038/ng0694-180}, pmid = {7920638}, url = {https://doi.org/10.1038/ng0694-180} } @article{cosentino2008-18401023, author = {Cosentino, S. and Scarmeas, N. and Helzner, E. and Glymour, M. M. and Brandt, J. and Albert, M. and Blacker, D. and Stern, Y.}, title = {{APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000304038.37421.cc}, pmid = {18401023}, url = {https://doi.org/10.1212/01.wnl.0000304038.37421.cc} } @article{kadotani2001-11401610, author = {Kadotani, H. and Kadotani, T. and Young, T. and Peppard, P. E. and Finn, L. and Colrain, I. M. and Murphy, G. M. and Mignot, E.}, title = {{Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults}}, journal = {JAMA}, year = {2001}, doi = {10.1001/jama.285.22.2888}, pmid = {11401610}, url = {https://doi.org/10.1001/jama.285.22.2888} } @article{belloy2020-32282020, author = {Belloy, M. E. and Napolioni, V. and Han, S. S. and Le Guen, Y. and Greicius, M. D. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.0414}, pmid = {32282020}, url = {https://doi.org/10.1001/jamaneurol.2020.0414} } @article{rogaeva1998-9718052, author = {Rogaeva, E. and Premkumar, S. and Song, Y. and Sorbi, S. and Brindle, N. and Paterson, A. and Duara, R. and Levesque, G. and others}, title = {{Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity}}, journal = {JAMA}, year = {1998}, doi = {10.1001/jama.280.7.614}, pmid = {9718052}, url = {https://doi.org/10.1001/jama.280.7.614} } @article{nadkarni2017-27842173, author = {Nadkarni, N. K. and Perera, S. and Snitz, B. E. and Mathis, C. A. and Price, J. and Williamson, J. D. and DeKosky, S. T. and Klunk, W. E. and others}, title = {{Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2016.3474}, pmid = {27842173}, url = {https://doi.org/10.1001/jamaneurol.2016.3474} } @article{sanders2010-20068209, author = {Sanders, A. E. and Wang, C. and Katz, M. and Derby, C. A. and Barzilai, N. and Ozelius, L. and Lipton, R. B.}, title = {{Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia}}, journal = {JAMA}, year = {2010}, doi = {10.1001/jama.2009.1988}, pmid = {20068209}, url = {https://doi.org/10.1001/jama.2009.1988} } @article{lopera2023-37188781, author = {Lopera, F. and Marino, C. and Chandrahas, A. S. and O'Hare, M. and Villalba-Moreno, N. D. and Aguillon, D. and Baena, A. and Sanchez, J. S. and Vila-Castelar, C. and Ramirez Gomez, L. and Chmielewska, N. and Oliveira, G. M. and others}, title = {{Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man}}, journal = {Nature Medicine}, year = {2023}, doi = {10.1038/s41591-023-02318-3}, pmid = {37188781}, url = {https://doi.org/10.1038/s41591-023-02318-3} } @article{rajabli2023-36539198, author = {Rajabli, F. and Tosto, G. and Hamilton-Nelson, K. L. and Kunkle, B. W. and Vardarajan, B. N. and Naj, A. and Whitehead, P. G. and Gardner, O. K. and Bush, W. S. and Sariya, S. and Mayeux, R. P. and Farrer, L. A. and others}, title = {{Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans}}, journal = {Alzheimer's \& Dementia}, year = {2023}, doi = {10.1002/alz.12865}, pmid = {36539198}, url = {https://doi.org/10.1002/alz.12865} } @article{rasmussen2015-25469919, author = {Rasmussen, K. L. and Tybjaerg-Hansen, A. and Nordestgaard, B. G. and Frikke-Schmidt, R.}, title = {{Plasma levels of apolipoprotein E and risk of dementia in the general population}}, journal = {Annals of neurology}, year = {2015}, doi = {10.1002/ana.24326}, pmid = {25469919}, url = {https://doi.org/10.1002/ana.24326} } @article{khachaturian2004-15123497, author = {Khachaturian, A. S. and Corcoran, C. D. and Mayer, L. S. and Zandi, P. P. and Breitner, J. C. and {Cache County Study Investigators}}, title = {{Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study}}, journal = {Archives of general psychiatry}, year = {2004}, doi = {10.1001/archpsyc.61.5.518}, pmid = {15123497}, url = {https://doi.org/10.1001/archpsyc.61.5.518} } @article{norgren2026-41854609, author = {Norgren, Jakob and Carballo‐Casla, Adrián and Grande, Giulia and Börjesson‐Hanson, Anne and Xu, Hong and Eriksdotter, Maria and Laukka, Erika J and Ptacek, Sara Garcia}, title = {{Meat Consumption and Cognitive Health by APOE Genotype}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.6489}, pmid = {41854609}, url = {https://doi.org/10.1001/jamanetworkopen.2026.6489} } @article{zhang2015-c9959eeb, author = {Zhang, Yong and Zhang, Linlin and Cao, Bo}, title = {{The Association Between Serum ApoE Genetic Polymorphism and Serum Lipid Level in Hemodialysis Patients}}, journal = {Genetic Testing and Molecular Biomarkers}, year = {2015}, doi = {10.1089/gtmb.2014.0267}, url = {https://doi.org/10.1089/gtmb.2014.0267} } @article{strittmatter1993-8446617, author = {Strittmatter, W. J. and Saunders, A. M. and Schmechel, D. and Pericak-Vance, M. and Enghild, J. and Salvesen, G. S. and Roses, A. D.}, title = {{Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1993}, doi = {10.1073/pnas.90.5.1977}, pmid = {8446617}, url = {https://doi.org/10.1073/pnas.90.5.1977} } @article{kivipelto2002-12160362, author = {Kivipelto, M. and Helkala, E. L. and Laakso, M. P. and Hänninen, T. and Hallikainen, M. and Alhainen, K. and Iivonen, S. and Mannermaa, A. and others}, title = {{Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease}}, journal = {Annals of internal medicine}, year = {2002}, doi = {10.7326/0003-4819-137-3-200208060-00006}, pmid = {12160362}, url = {https://doi.org/10.7326/0003-4819-137-3-200208060-00006} } @article{buckley2018-29803541, author = {Buckley, R. F. and Mormino, E. C. and Amariglio, R. E. and Properzi, M. J. and Rabin, J. S. and Lim, Y. Y. and Papp, K. V. and Jacobs, H. I. L. and others}, title = {{Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2018}, doi = {10.1016/j.jalz.2018.04.010}, pmid = {29803541}, url = {https://doi.org/10.1016/j.jalz.2018.04.010} } @article{wilson2002-12117364, author = {Wilson, R. S. and Schneider, J. A. and Barnes, L. L. and Beckett, L. A. and Aggarwal, N. T. and Cochran, E. J. and Berry-Kravis, E. and Bach, J. and others}, title = {{The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period}}, journal = {Archives of neurology}, year = {2002}, doi = {10.1001/archneur.59.7.1154}, pmid = {12117364}, url = {https://doi.org/10.1001/archneur.59.7.1154} } @article{protas2013-23599929, author = {Protas, H. D. and Chen, K. and Langbaum, J. B. and Fleisher, A. S. and Alexander, G. E. and Lee, W. and Bandy, D. and de Leon, M. J. and others}, title = {{Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/2013.jamaneurol.286}, pmid = {23599929}, url = {https://doi.org/10.1001/2013.jamaneurol.286} } @article{vardarajan2015-26101835, author = {Vardarajan, B. N. and Ghani, M. and Kahn, A. and Sheikh, S. and Sato, C. and Barral, S. and Lee, J. H. and Cheng, R. and others}, title = {{Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci}}, journal = {Annals of neurology}, year = {2015}, doi = {10.1002/ana.24466}, pmid = {26101835}, url = {https://doi.org/10.1002/ana.24466} } @article{sampedro2015-26397226, author = {Sampedro, F. and Vilaplana, E. and de Leon, M. J. and Alcolea, D. and Pegueroles, J. and Montal, V. and Carmona-Iragui, M. and Sala, I. and others}, title = {{APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls}}, journal = {Oncotarget}, year = {2015}, doi = {10.18632/oncotarget.5185}, pmid = {26397226}, url = {https://doi.org/10.18632/oncotarget.5185} } @article{graffradford2002-11939894, author = {Graff-Radford, N. R. and Green, R. C. and Go, R. C. and Hutton, M. L. and Edeki, T. and Bachman, D. and Adamson, J. L. and Griffith, P. and others}, title = {{Association between apolipoprotein E genotype and Alzheimer disease in African American subjects}}, journal = {Archives of neurology}, year = {2002}, doi = {10.1001/archneur.59.4.594}, pmid = {11939894}, url = {https://doi.org/10.1001/archneur.59.4.594} } @article{clocchiattituozzo2025-40549373, author = {Clocchiatti‐Tuozzo, Santiago and Rivier, Cyprien A. and Renedo, Daniela B. and Huo, Shufan and de Havenon, Adam and Hawkes, Maximiliano A. and Gilmore, Emily J. and Schwamm, Lee H. and others}, title = {{APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.0182}, pmid = {40549373}, url = {https://doi.org/10.1001/jamaneurol.2025.0182} } @article{castellano2011-21715678, author = {Castellano, Joseph M. and Kim, Jungsu and Stewart, Floy R. and Jiang, Hong and Demattos, Ronald Bradley and Patterson, Bruce W. and Fagan, Anne M. and Morris, John C. and Mawuenyega, Kwasi G. and Cruchaga, Carlos C and Goate, Alison and Bales, Kelly R. and Paul, Steven M. and Bateman, Randall John and Holtzman, David M.}, title = {{Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance}}, journal = {Science Translational Medicine}, year = {2011}, doi = {10.1126/scitranslmed.3002156}, pmid = {21715678}, url = {https://doi.org/10.1126/scitranslmed.3002156} } @article{moysich2000-10642431, author = {Moysich, K B and Freudenheim, J L and Baker, J A and Ambrosone, C B and Bowman, E D and Schisterman, E F and Vena, J E and Shields, P G}, title = {{Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk}}, journal = {Molecular carcinogenesis}, year = {2000}, doi = {10.1002/(sici)1098-2744(200001)27:1<2::aid-mc2>3.0.co;2-w}, pmid = {10642431}, url = {https://doi.org/10.1002/(sici)1098-2744(200001)27:1<2::aid-mc2>3.0.co;2-w} } @article{quenez2026-42648288, author = {Quenez, O. and Schramm, C. and Cassinari, K. and Nicolas, A. and Groeneveld, J. and Huguet, G. and Grenier-Boley, B. and Hulsman, M. and Walters, G. B. and de Rojas, I. and Rovelet-Lecrux, A. and Feuillette, S. and others}, title = {{Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk}}, journal = {American Journal of Human Genetics}, year = {2026}, doi = {10.1016/j.ajhg.2026.07.013}, pmid = {42648288}, url = {https://doi.org/10.1016/j.ajhg.2026.07.013} } @article{brutman2026-41629326, author = {Brutman, J. N. and Busald, T. and Nizamis, E. and Kaufman, E. J. and Lin, E. and Hendricks, N. E. and Chintamen, S. and Sulovari, A. and Smukowski, S. N. and Ye, Y. and Peikon, I. and Jayadev, S. and others}, title = {{A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans}}, journal = {Nature Communications}, year = {2026}, doi = {10.1038/s41467-026-68808-3}, pmid = {41629326}, url = {https://doi.org/10.1038/s41467-026-68808-3} } @article{ma1994-7969426, author = {Ma, J. and Yee, A. and Brewer, H. B. and Das, S. and Potter, H.}, title = {{Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments}}, journal = {Nature}, year = {1994}, doi = {10.1038/372092a0}, pmid = {7969426}, url = {https://doi.org/10.1038/372092a0} } @article{rodrigue2012-22302550, author = {Rodrigue, K. M. and Kennedy, K. M. and Devous, M. D. and Rieck, JR. and Hebrank, A. C. and Diaz-Arrastia, R. and Mathews, D. and Park, D. C.}, title = {{β-Amyloid burden in healthy aging: regional distribution and cognitive consequences}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e318245d295}, pmid = {22302550}, url = {https://doi.org/10.1212/wnl.0b013e318245d295} } @article{evans2003-12580702, author = {Evans, D. A. and Bennett, D. A. and Wilson, R. S. and Bienias, J. L. and Morris, M. C. and Scherr, P. A. and Hebert, L. E. and Aggarwal, N. and others}, title = {{Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status}}, journal = {Archives of neurology}, year = {2003}, doi = {10.1001/archneur.60.2.185}, pmid = {12580702}, url = {https://doi.org/10.1001/archneur.60.2.185} } @article{thambisetty2010-20065135, author = {Thambisetty, M. and Beason-Held, L. and An, Y. and Kraut, M. A. and Resnick, S. M.}, title = {{APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging}}, journal = {Archives of neurology}, year = {2010}, doi = {10.1001/archneurol.2009.913}, pmid = {20065135}, url = {https://doi.org/10.1001/archneurol.2009.913} } @article{mata2014-25178429, author = {Mata, I. F. and Leverenz, J. B. and Weintraub, D. and Trojanowski, J. Q. and Hurtig, H. I. and Van Deerlin, V. M. and Ritz, B. and Rausch, R. and others}, title = {{APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.1455}, pmid = {25178429}, url = {https://doi.org/10.1001/jamaneurol.2014.1455} } @article{lee2011-21059989, author = {Lee, J. H. and Cheng, R. and Barral, S. and Reitz, C. and Medrano, M. and Lantigua, R. and Jiménez-Velazquez, I. Z. and Rogaeva, E. and others}, title = {{Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2010.292}, pmid = {21059989}, url = {https://doi.org/10.1001/archneurol.2010.292} } @article{shulman2013-23836404, author = {Shulman, J. M. and Chen, K. and Keenan, B. T. and Chibnik, L. B. and Fleisher, A. and Thiyyagura, P. and Roontiva, A. and McCabe, C. and others}, title = {{Genetic susceptibility for Alzheimer disease neuritic plaque pathology}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.2815}, pmid = {23836404}, url = {https://doi.org/10.1001/jamaneurol.2013.2815} } @article{li2004-15184605, author = {Li, Y. J. and Hauser, M. A. and Scott, W. K. and Martin, E. R. and Booze, M. W. and Qin, X. J. and Walter, J. W. and Nance, M. A. and others}, title = {{Apolipoprotein E controls the risk and age at onset of Parkinson disease}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000128089.53030.ac}, pmid = {15184605}, url = {https://doi.org/10.1212/01.wnl.0000128089.53030.ac} } @article{griswold2021-33522086, author = {Griswold, A. J. and Celis, K. and Bussies, P. L. and Rajabli, F. and Whitehead, P. L. and Hamilton-Nelson, K. L. and Beecham, G. W. and Dykxhoorn, D. M. and others}, title = {{Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2021}, doi = {10.1002/alz.12287}, pmid = {33522086}, url = {https://doi.org/10.1002/alz.12287} } @article{devanand2005-15956169, author = {Devanand, D. P. and Pelton, G. H. and Zamora, D. and Liu, X. and Tabert, M. H. and Goodkind, M. and Scarmeas, N. and Braun, I. and others}, title = {{Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment}}, journal = {Archives of neurology}, year = {2005}, doi = {10.1001/archneur.62.6.975}, pmid = {15956169}, url = {https://doi.org/10.1001/archneur.62.6.975} } @article{kunkle2025-41437928, author = {Kunkle, Brian W. and Gomez, Lissette and Tosto, Giuseppe and Rodriguez, Omar Garcia and Slifer, Susan H. and Hamilton‐Nelson, Kara L. and Naj, Adam Christian and Kushch, Nicholas A. and others}, title = {{Novel sex‐specific candidate loci associated with Alzheimer disease identified through sex‐aware multi‐ancestry genome‐wide meta‐analysis}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_106407}, pmid = {41437928}, url = {https://doi.org/10.1002/alz70855_106407} } @article{mahley1988-3283935, author = {Mahley, Robert W.}, title = {{Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology}}, journal = {Science}, year = {1988}, doi = {10.1126/science.3283935}, pmid = {3283935}, url = {https://doi.org/10.1126/science.3283935} } @article{verghese2011-21349439, author = {Verghese, Philip B. and Castellano, Joseph M. and Holtzman, David M.}, title = {{Apolipoprotein E in Alzheimer's disease and other neurological disorders}}, journal = {The Lancet Neurology}, year = {2011}, doi = {10.1016/s1474-4422(10)70325-2}, pmid = {21349439}, url = {https://doi.org/10.1016/s1474-4422(10)70325-2} } @article{lu2026-42141098, author = {Lu, L. and Pichet Binette, A. and Hristovska, I. and Janelidze, S. and Smets, B. and Cumplido-Mayoral, I. and Vasanthakumar, A. and Milkovich, B. and An, L. and Ossenkoppele, R. and Krish, V. and others}, title = {{Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease}}, journal = {Nature Aging}, year = {2026}, doi = {10.1038/s43587-026-01123-0}, pmid = {42141098}, url = {https://doi.org/10.1038/s43587-026-01123-0} } @article{liu2013-23296339, author = {Liu, C. C. and Kanekiyo, T. and Xu, H. and Bu, G.}, title = {{Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy}}, journal = {Nature reviews. Neurology}, year = {2013}, doi = {10.1038/nrneurol.2012.263}, pmid = {23296339}, url = {https://doi.org/10.1038/nrneurol.2012.263} } @article{genin2011-21556001, author = {Genin, E. and Hannequin, D. and Wallon, D. and Sleegers, K. and Hiltunen, M. and Combarros, O. and Bullido, M. J. and Engelborghs, S. and others}, title = {{APOE and Alzheimer disease: a major gene with semi-dominant inheritance}}, journal = {Molecular psychiatry}, year = {2011}, doi = {10.1038/mp.2011.52}, pmid = {21556001}, url = {https://doi.org/10.1038/mp.2011.52} } @article{blacker1998-9697696, author = {Blacker, D. and Wilcox, M. A. and Laird, N. M. and Rodes, L. and Horvath, S. M. and Go, R. C. and Perry, R. and Watson, B. and others}, title = {{Alpha-2 macroglobulin is genetically associated with Alzheimer disease}}, journal = {Nature genetics}, year = {1998}, doi = {10.1038/1243}, pmid = {9697696}, url = {https://doi.org/10.1038/1243} } @article{alcolea2015-26180139, author = {Alcolea, D. and Martínez-Lage, P. and Sánchez-Juan, P. and Olazarán, J. and Antúnez, C. and Izagirre, A. and Ecay-Torres, M. and Estanga, A. and others}, title = {{Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001859}, pmid = {26180139}, url = {https://doi.org/10.1212/wnl.0000000000001859} } @article{cuyvers2015-26141617, author = {Cuyvers, E. and De Roeck, A. and Van den Bossche, T. and Van Cauwenberghe, C. and Bettens, K. and Vermeulen, S. and Mattheijssens, M. and Peeters, K. and others}, title = {{Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study}}, journal = {The Lancet. Neurology}, year = {2015}, doi = {10.1016/s1474-4422(15)00133-7}, pmid = {26141617}, url = {https://doi.org/10.1016/s1474-4422(15)00133-7} } @article{naj2010-20885792, author = {Naj, A. C. and Beecham, G. W. and Martin, E. R. and Gallins, P. J. and Powell, E. H. and Konidari, I. and Whitehead, P. L. and Cai, G. and others}, title = {{Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities}}, journal = {PLoS genetics}, year = {2010}, doi = {10.1371/journal.pgen.1001130}, pmid = {20885792}, url = {https://doi.org/10.1371/journal.pgen.1001130} } @article{brase2023-37085492, author = {Brase, L. and You, S. F. and D'Oliveira Albanus, R. and Del-Aguila, J. L. and Dai, Y. and Novotny, B. C. and Soriano-Tarraga, C. and Dykstra, T. and others}, title = {{Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers}}, journal = {Nature communications}, year = {2023}, doi = {10.1038/s41467-023-37437-5}, pmid = {37085492}, url = {https://doi.org/10.1038/s41467-023-37437-5} } @article{deane2008-19033669, author = {Deane, R. and Sagare, A. and Hamm, K. and Parisi, M. and Lane, S. and Finn, M. B. and Holtzman, D. M. and Zlokovic, B. V.}, title = {{apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain}}, journal = {The Journal of clinical investigation}, year = {2008}, doi = {10.1172/jci36663}, pmid = {19033669}, url = {https://doi.org/10.1172/jci36663} } @article{lim2005-15788759, author = {Lim, G. P. and Calon, F. and Morihara, T. and Yang, F. and Teter, B. and Ubeda, O. and Salem, N. and Frautschy, S. A. and others}, title = {{A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2005}, doi = {10.1523/jneurosci.4225-04.2005}, pmid = {15788759}, url = {https://doi.org/10.1523/jneurosci.4225-04.2005} } @article{mosconi2004-15623696, author = {Mosconi, L. and Perani, D. and Sorbi, S. and Herholz, K. and Nacmias, B. and Holthoff, V. and Salmon, E. and Baron, J. C. and others}, title = {{MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000147469.18313.3b}, pmid = {15623696}, url = {https://doi.org/10.1212/01.wnl.0000147469.18313.3b} } @article{kok2009-19557866, author = {Kok, E. and Haikonen, S. and Luoto, T. and Huhtala, H. and Goebeler, S. and Haapasalo, H. and Karhunen, P. J.}, title = {{Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age}}, journal = {Annals of neurology}, year = {2009}, doi = {10.1002/ana.21696}, pmid = {19557866}, url = {https://doi.org/10.1002/ana.21696} } @article{tan2003-12742802, author = {Tan, Z. S. and Seshadri, S. and Beiser, A. and Wilson, P. W. and Kiel, D. P. and Tocco, M. and D'Agostino, R. B. and Wolf, P. A.}, title = {{Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study}}, journal = {Archives of internal medicine}, year = {2003}, doi = {10.1001/archinte.163.9.1053}, pmid = {12742802}, url = {https://doi.org/10.1001/archinte.163.9.1053} } @article{serranopozo2015-25623662, author = {Serrano-Pozo, A. and Qian, J. and Monsell, S. E. and Betensky, R. A. and Hyman, B. T.}, title = {{APOEε2 is associated with milder clinical and pathological Alzheimer disease}}, journal = {Annals of neurology}, year = {2015}, doi = {10.1002/ana.24369}, pmid = {25623662}, url = {https://doi.org/10.1002/ana.24369} } @article{vemuri2010-20373342, author = {Vemuri, P. and Wiste, H. J. and Weigand, S. D. and Knopman, D. S. and Shaw, L. M. and Trojanowski, J. Q. and Aisen, P. S. and Weiner, M. and others}, title = {{Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease}}, journal = {Annals of neurology}, year = {2010}, doi = {10.1002/ana.21953}, pmid = {20373342}, url = {https://doi.org/10.1002/ana.21953} } @article{finckh2000-11074789, author = {Finckh, U. and von der Kammer, H. and Velden, J. and Michel, T. and Andresen, B. and Deng, A. and Zhang, J. and Müller-Thomsen, T. and others}, title = {{Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease}}, journal = {Archives of neurology}, year = {2000}, doi = {10.1001/archneur.57.11.1579}, pmid = {11074789}, url = {https://doi.org/10.1001/archneur.57.11.1579} } @article{schneider2005-15774818, author = {Schneider, J. A. and Bienias, J. L. and Wilson, R. S. and Berry-Kravis, E. and Evans, D. A. and Bennett, D. A.}, title = {{The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons}}, journal = {Stroke}, year = {2005}, doi = {10.1161/01.str.0000160747.27470.2a}, pmid = {15774818}, url = {https://doi.org/10.1161/01.str.0000160747.27470.2a} } @article{voevodskaya2016-27164711, author = {Voevodskaya, O. and Sundgren, P. C. and Strandberg, O. and Zetterberg, H. and Minthon, L. and Blennow, K. and Wahlund, L. O. and Westman, E. and others}, title = {{Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000002672}, pmid = {27164711}, url = {https://doi.org/10.1212/wnl.0000000000002672} } @article{ramanan2014-23419831, author = {Ramanan, V. K. and Risacher, S. L. and Nho, K. and Kim, S. and Swaminathan, S. and Shen, L. and Foroud, T. M. and Hakonarson, H. and others}, title = {{APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study}}, journal = {Molecular psychiatry}, year = {2014}, doi = {10.1038/mp.2013.19}, pmid = {23419831}, url = {https://doi.org/10.1038/mp.2013.19} } @article{strittmatter1993-8367470, author = {Strittmatter, W. J. and Weisgraber, K. H. and Huang, D. Y. and Dong, L. M. and Salvesen, G. S. and Pericak-Vance, M. and Schmechel, D. and Saunders, A. M. and others}, title = {{Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1993}, doi = {10.1073/pnas.90.17.8098}, pmid = {8367470}, url = {https://doi.org/10.1073/pnas.90.17.8098} } @article{scheff2007-17470753, author = {Scheff, S. W. and Price, D. A. and Schmitt, F. A. and DeKosky, S. T. and Mufson, E. J.}, title = {{Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000260698.46517.8f}, pmid = {17470753}, url = {https://doi.org/10.1212/01.wnl.0000260698.46517.8f} } @article{kemppainen2007-17485647, author = {Kemppainen, N. M. and Aalto, S. and Wilson, I. A. and Någren, K. and Helin, S. and Brück, A. and Oikonen, V. and Kailajärvi, M. and others}, title = {{PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000260969.94695.56}, pmid = {17485647}, url = {https://doi.org/10.1212/01.wnl.0000260969.94695.56} } @article{tiraboschi2004-15184600, author = {Tiraboschi, P. and Hansen, L. A. and Masliah, E. and Alford, M. and Thal, L. J. and Corey-Bloom, J.}, title = {{Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000128091.92139.0f}, pmid = {15184600}, url = {https://doi.org/10.1212/01.wnl.0000128091.92139.0f} } @article{wragg1996-8596269, author = {Wragg, M. and Hutton, M. and Talbot, C.}, title = {{Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group}}, journal = {Lancet (London, England)}, year = {1996}, doi = {10.1016/s0140-6736(96)91140-x}, pmid = {8596269}, url = {https://doi.org/10.1016/s0140-6736(96)91140-x} } @article{balasa2011-21576687, author = {Balasa, M. and Gelpi, E. and Antonell, A. and Rey, M. J. and Sánchez-Valle, R. and Molinuevo, J. L. and Lladó, A.}, title = {{Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e31821a44dd}, pmid = {21576687}, url = {https://doi.org/10.1212/wnl.0b013e31821a44dd} } @article{yin2020-32457210, author = {Yin, J. and Reiman, E. M. and Beach, T. G. and Serrano, G. E. and Sabbagh, M. N. and Nielsen, M. and Caselli, R. J. and Shi, J.}, title = {{Effect of ApoE isoforms on mitochondria in Alzheimer disease}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009582}, pmid = {32457210}, url = {https://doi.org/10.1212/wnl.0000000000009582} } @article{prince2004-15184629, author = {Prince, J. A. and Zetterberg, H. and Andreasen, N. and Marcusson, J. and Blennow, K.}, title = {{APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000128088.08695.05}, pmid = {15184629}, url = {https://doi.org/10.1212/01.wnl.0000128088.08695.05} } @article{cukier2016-27231719, author = {Cukier, H. N. and Kunkle, B. W. and Vardarajan, B. N. and Rolati, S. and Hamilton-Nelson, K. L. and Kohli, M. A. and Whitehead, P. L. and Dombroski, B. A. and others}, title = {{ABCA7 frameshift deletion associated with Alzheimer disease in African Americans}}, journal = {Neurology. Genetics}, year = {2016}, doi = {10.1212/nxg.0000000000000079}, pmid = {27231719}, url = {https://doi.org/10.1212/nxg.0000000000000079} } @article{allen2012-22494505, author = {Allen, M. and Zou, F. and Chai, H. S. and Younkin, C. S. and Miles, R. and Nair, A. A. and Crook, J. E. and Pankratz, V. S. and others}, title = {{Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications}}, journal = {Molecular neurodegeneration}, year = {2012}, doi = {10.1186/1750-1326-7-13}, pmid = {22494505}, url = {https://doi.org/10.1186/1750-1326-7-13} } @article{barral2012-22539578, author = {Barral, S. and Bird, T. and Goate, A. and Farlow, M. R. and Diaz-Arrastia, R. and Bennett, D. A. and Graff-Radford, N. and Boeve, B. F. and others}, title = {{Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182553c48}, pmid = {22539578}, url = {https://doi.org/10.1212/wnl.0b013e3182553c48} } @article{akgun2025-41434771, author = {Akgün, Bilçağ and Xu, Wanying and Hamilton‐Nelson, Kara L. and Nasciben, Luciana Bertholim and Scott, Kyle M. and Adams, Larry Deon and Sanchez, Jose J. and Valladares, Glenies S and others}, title = {{Significant association between SCN8A and Alzheimer disease in Puerto Ricans}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_098248}, pmid = {41434771}, url = {https://doi.org/10.1002/alz70855_098248} } @article{reiman2009-19346482, author = {Reiman, Eric M. and Chen, Kewei and Liu, Xiaofen and Bandy, Daniel J. and Yu, Meixiang and Lee, Wendy and Ayutyanont, Napatkamon and Keppler, Jennifer S. and Reeder, Stephanie and Langbaum, Jessica B. S. and Alexander, Gene E. and Klunk, William E. and Mathis, Chester A. and Price, Julie C. and Aizenstein, Howard Jay and DeKosky, Steven T. and Caselli, Richard J.}, title = {{Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease}}, journal = {Proceedings of the National Academy of Sciences}, year = {2009}, doi = {10.1073/pnas.0900345106}, pmid = {19346482}, url = {https://doi.org/10.1073/pnas.0900345106} } @article{rebeck1993-8398148, author = {Rebeck, George William and Reiter, Joell S. and Strickland, Dudley K. and Hyman, Bradley T.}, title = {{Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions}}, journal = {Neuron}, year = {1993}, doi = {10.1016/0896-6273(93)90070-8}, pmid = {8398148}, url = {https://doi.org/10.1016/0896-6273(93)90070-8} } @article{bu2009-19339974, author = {Bu, Guojun}, title = {{Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy}}, journal = {Nature reviews. Neuroscience}, year = {2009}, doi = {10.1038/nrn2620}, pmid = {19339974}, url = {https://doi.org/10.1038/nrn2620} } @article{fu2012-23023945, author = {Fu, Rao and Yanjanin, Nicole M and Elrick, Matthew J and Ware, Christopher and Lieberman, Andrew P and Porter, Forbes D}, title = {{Apolipoprotein E genotype and neurological disease onset in Niemann-Pick disease, type C1}}, journal = {American journal of medical genetics. Part A}, year = {2012}, doi = {10.1002/ajmg.a.35395}, pmid = {23023945}, url = {https://doi.org/10.1002/ajmg.a.35395} } @article{yamazaki2019-31367008, author = {Yamazaki, Y. and Zhao, N. and Caulfield, T. R. and Liu, C. C. and Bu, G.}, title = {{Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies}}, journal = {Nature reviews. Neurology}, year = {2019}, doi = {10.1038/s41582-019-0228-7}, pmid = {31367008}, url = {https://doi.org/10.1038/s41582-019-0228-7} } @article{schmechel1993-8415756, author = {Schmechel, D. E. and Saunders, A. M. and Strittmatter, W. J. and Crain, B. J. and Hulette, C. M. and Joo, S. H. and Pericak-Vance, M. A. and Goldgaber, D. and others}, title = {{Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1993}, doi = {10.1073/pnas.90.20.9649}, pmid = {8415756}, url = {https://doi.org/10.1073/pnas.90.20.9649} } @article{qin2009-19273754, author = {Qin, W. and Haroutunian, V. and Katsel, P. and Cardozo, C. P. and Ho, L. and Buxbaum, J. D. and Pasinetti, G. M.}, title = {{PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia}}, journal = {Archives of neurology}, year = {2009}, doi = {10.1001/archneurol.2008.588}, pmid = {19273754}, url = {https://doi.org/10.1001/archneurol.2008.588} } @article{chen2021-33176118, author = {Chen, Y. and Strickland, M. R. and Soranno, A. and Holtzman, D. M.}, title = {{Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis}}, journal = {Neuron}, year = {2021}, doi = {10.1016/j.neuron.2020.10.008}, pmid = {33176118}, url = {https://doi.org/10.1016/j.neuron.2020.10.008} } @article{irie2008-18195144, author = {Irie, F. and Fitzpatrick, A. L. and Lopez, O. L. and Kuller, L. H. and Peila, R. and Newman, A. B. and Launer, L. J.}, title = {{Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study}}, journal = {Archives of neurology}, year = {2008}, doi = {10.1001/archneurol.2007.29}, pmid = {18195144}, url = {https://doi.org/10.1001/archneurol.2007.29} } @article{pericakvance1997-9333264, author = {Pericak-Vance, M. A. and Bass, M. P. and Yamaoka, L. H. and Gaskell, P. C. and Scott, W. K. and Terwedow, H. A. and Menold, M. M. and Conneally, P. M. and others}, title = {{Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12}}, journal = {JAMA}, year = {1997}, doi = {10.1001/jama.1997.03550150041033}, pmid = {9333264}, url = {https://doi.org/10.1001/jama.1997.03550150041033} } @article{jun2017-28183528, author = {Jun, G. R. and Chung, J. and Mez, J. and Barber, R. and Beecham, G. W. and Bennett, D. A. and Buxbaum, J. D. and Byrd, G. S. and others}, title = {{Transethnic genome-wide scan identifies novel Alzheimer's disease loci}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.12.012}, pmid = {28183528}, url = {https://doi.org/10.1016/j.jalz.2016.12.012} } @article{liao2018-29600961, author = {Liao, F. and Li, A. and Xiong, M. and Bien-Ly, N. and Jiang, H. and Zhang, Y. and Finn, M. B. and Hoyle, R. and others}, title = {{Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation}}, journal = {The Journal of clinical investigation}, year = {2018}, doi = {10.1172/jci96429}, pmid = {29600961}, url = {https://doi.org/10.1172/jci96429} } @article{bartzokis2006-16389198, author = {Bartzokis, G. and Lu, P. H. and Geschwind, D. H. and Edwards, N. and Mintz, J. and Cummings, J. L.}, title = {{Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia}}, journal = {Archives of general psychiatry}, year = {2006}, doi = {10.1001/archpsyc.63.1.63}, pmid = {16389198}, url = {https://doi.org/10.1001/archpsyc.63.1.63} } @article{hendrie2014-24565289, author = {Hendrie, H. C. and Murrell, J. and Baiyewu, O. and Lane, K. A. and Purnell, C. and Ogunniyi, A. and Unverzagt, F. W. and Hall, K. and others}, title = {{APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba}}, journal = {International psychogeriatrics}, year = {2014}, doi = {10.1017/s1041610214000167}, pmid = {24565289}, url = {https://doi.org/10.1017/s1041610214000167} } @article{slattery2017-28578156, author = {Slattery, C. F. and Zhang, J. and Paterson, R. W. and Foulkes, A. J. M. and Carton, A. and Macpherson, K. and Mancini, L. and Thomas, D. L. and others}, title = {{ApoE influences regional white-matter axonal density loss in Alzheimer's disease}}, journal = {Neurobiology of aging}, year = {2017}, doi = {10.1016/j.neurobiolaging.2017.04.021}, pmid = {28578156}, url = {https://doi.org/10.1016/j.neurobiolaging.2017.04.021} } @article{cruchaga2011-21825236, author = {Cruchaga, C. and Nowotny, P. and Kauwe, J. S. and Ridge, P. G. and Mayo, K. and Bertelsen, S. and Hinrichs, A. and Fagan, A. M. and others}, title = {{Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2011.155}, pmid = {21825236}, url = {https://doi.org/10.1001/archneurol.2011.155} } @article{bennett2009-19398704, author = {Bennett, D. A. and De Jager, P. L. and Leurgans, S. E. and Schneider, J. A.}, title = {{Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181a2e87d}, pmid = {19398704}, url = {https://doi.org/10.1212/wnl.0b013e3181a2e87d} } @article{hixson1990-2341813, author = {Hixson, James E. and Vernier, D.T.}, title = {{Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI}}, journal = {Journal of Lipid Research}, year = {1990}, doi = {10.1016/s0022-2275(20)43176-1}, pmid = {2341813}, url = {https://doi.org/10.1016/s0022-2275(20)43176-1} } @article{li2023-37260021, author = {Li, D. and Farrell, J. J. and Mez, J. and Martin, E. R. and Bush, W. S. and Ruiz, A. and Boada, M. and de Rojas, I. and Mayeux, R. and Haines, J. L. and Vance, M. A. P. and Wang, L. S. and others}, title = {{Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews}}, journal = {Alzheimer's \& Dementia}, year = {2023}, doi = {10.1002/alz.13117}, pmid = {37260021}, url = {https://doi.org/10.1002/alz.13117} } @article{hung2024-38527856, author = {Hung, C. and Fertan, E. and Livesey, F. J. and Klenerman, D. and Patani, R.}, title = {{APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease}}, journal = {Brain}, year = {2024}, doi = {10.1093/brain/awae092}, pmid = {38527856}, url = {https://doi.org/10.1093/brain/awae092} } @article{koistinaho2004-15195085, author = {Koistinaho, M. and Lin, S. and Wu, X. and Esterman, M. and Koger, D. and Hanson, J. and Higgs, R. and Liu, F. and others}, title = {{Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides}}, journal = {Nature medicine}, year = {2004}, doi = {10.1038/nm1058}, pmid = {15195085}, url = {https://doi.org/10.1038/nm1058} } @article{guillotsestier2015-25619654, author = {Guillot-Sestier, M. V. and Doty, K. R. and Gate, D. and Rodriguez, J. and Leung, B. P. and Rezai-Zadeh, K. and Town, T.}, title = {{Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology}}, journal = {Neuron}, year = {2015}, doi = {10.1016/j.neuron.2014.12.068}, pmid = {25619654}, url = {https://doi.org/10.1016/j.neuron.2014.12.068} } @article{sierksma2020-31951107, author = {Sierksma, A. and Lu, A. and Mancuso, R. and Fattorelli, N. and Thrupp, N. and Salta, E. and Zoco, J. and Blum, D. and others}, title = {{Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology}}, journal = {EMBO molecular medicine}, year = {2020}, doi = {10.15252/emmm.201910606}, pmid = {31951107}, url = {https://doi.org/10.15252/emmm.201910606} } @article{huynh2017-29216448, author = {Huynh, T. V. and Liao, F. and Francis, C. M. and Robinson, G. O. and Serrano, JR. and Jiang, H. and Roh, J. and Finn, M. B. and others}, title = {{Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis}}, journal = {Neuron}, year = {2017}, doi = {10.1016/j.neuron.2017.11.014}, pmid = {29216448}, url = {https://doi.org/10.1016/j.neuron.2017.11.014} } @article{blumenfeld2024-38191720, author = {Blumenfeld, J. and Yip, O. and Kim, M. J. and Huang, Y.}, title = {{Cell type-specific roles of APOE4 in Alzheimer disease}}, journal = {Nature reviews. Neuroscience}, year = {2024}, doi = {10.1038/s41583-023-00776-9}, pmid = {38191720}, url = {https://doi.org/10.1038/s41583-023-00776-9} } @article{sabuncu2012-22169231, author = {Sabuncu, M. R. and Buckner, R. L. and Smoller, J. W. and Lee, P. H. and Fischl, B. and Sperling, R. A. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects}}, journal = {Cerebral cortex (New York, N.Y. : 1991)}, year = {2012}, doi = {10.1093/cercor/bhr348}, pmid = {22169231}, url = {https://doi.org/10.1093/cercor/bhr348} } @article{kovacs2016-27016065, author = {Kovacs, G. G. and Lutz, M. I. and Ricken, G. and Ströbel, T. and Höftberger, R. and Preusser, M. and Regelsberger, G. and Hönigschnabl, S. and others}, title = {{Dura mater is a potential source of Aβ seeds}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-016-1565-x}, pmid = {27016065}, url = {https://doi.org/10.1007/s00401-016-1565-x} } @article{lowe2014-24793183, author = {Lowe, V. J. and Weigand, S. D. and Senjem, M. L. and Vemuri, P. and Jordan, L. and Kantarci, K. and Boeve, B. and Jack, C. R. and others}, title = {{Association of hypometabolism and amyloid levels in aging, normal subjects}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000467}, pmid = {24793183}, url = {https://doi.org/10.1212/wnl.0000000000000467} } @article{holtzman2000-10694577, author = {Holtzman, David M. and Bales, Kelly R. and Tenkova, Tanya and Fagan, Anne M. and Parsadanian, Maia and Sartorius, Leah J. and Mackey, Brian and Olney, John W. and McKeel, Daniel W. and Wozniak, David F. and Paul, Steven M.}, title = {{Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease}}, journal = {Proceedings of the National Academy of Sciences}, year = {2000}, doi = {10.1073/pnas.050004797}, pmid = {10694577}, url = {https://doi.org/10.1073/pnas.050004797} } @article{small2000-10811879, author = {Small, G. W. and Ercoli, L. M. and Silverman, D. H. and Huang, S. C. and Komo, S. and Bookheimer, S. Y. and Lavretsky, H. and Miller, K. and others}, title = {{Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2000}, doi = {10.1073/pnas.090106797}, pmid = {10811879}, url = {https://doi.org/10.1073/pnas.090106797} } @article{arboledavelasquez2019-31686034, author = {Arboleda-Velasquez, J. F. and Lopera, F. and O'Hare, M. and Delgado-Tirado, S. and Marino, C. and Chmielewska, N. and Saez-Torres, K. L. and Amarnani, D. and others}, title = {{Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report}}, journal = {Nature medicine}, year = {2019}, doi = {10.1038/s41591-019-0611-3}, pmid = {31686034}, url = {https://doi.org/10.1038/s41591-019-0611-3} } @article{itzhaki1997-9014911, author = {Itzhaki, R. F. and Lin, W. R. and Shang, D. and Wilcock, G. K. and Faragher, B. and Jamieson, G. A.}, title = {{Herpes simplex virus type 1 in brain and risk of Alzheimer's disease}}, journal = {Lancet (London, England)}, year = {1997}, doi = {10.1016/s0140-6736(96)10149-5}, pmid = {9014911}, url = {https://doi.org/10.1016/s0140-6736(96)10149-5} } @article{liampas2025-40943487, author = {Liampas, Ioannis and Demiri, Silvia and Siokas, Vasileios and Tsika, Antonia and Marogianni, Chrysa and Stamati, Polyxeni and Nasios, Grigorios and Messinis, Lambros and others}, title = {{Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia}}, journal = {International journal of molecular sciences}, year = {2025}, doi = {10.3390/ijms26178562}, pmid = {40943487}, url = {https://doi.org/10.3390/ijms26178562} } @article{holtzman2012-22393530, author = {Holtzman, D. M. and Herz, J. and Bu, G.}, title = {{Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease}}, journal = {Cold Spring Harbor perspectives in medicine}, year = {2012}, doi = {10.1101/cshperspect.a006312}, pmid = {22393530}, url = {https://doi.org/10.1101/cshperspect.a006312} } @article{cataldo1997-9236226, author = {Cataldo, A. M. and Barnett, J. L. and Pieroni, C. and Nixon, R. A.}, title = {{Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {1997}, doi = {10.1523/jneurosci.17-16-06142.1997}, pmid = {9236226}, url = {https://doi.org/10.1523/jneurosci.17-16-06142.1997} } @article{poirier1995-8618881, author = {Poirier, J. and Delisle, M. C. and Quirion, R. and Aubert, I. and Farlow, M. and Lahiri, D. and Hui, S. and Bertrand, P. and others}, title = {{Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1995}, doi = {10.1073/pnas.92.26.12260}, pmid = {8618881}, url = {https://doi.org/10.1073/pnas.92.26.12260} } @article{wahrle2008-18202749, author = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Kim, J. and Li, A. and Knoten, A. and Jain, S. and Hirsch-Reinshagen, V. and others}, title = {{Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease}}, journal = {The Journal of clinical investigation}, year = {2008}, doi = {10.1172/jci33622}, pmid = {18202749}, url = {https://doi.org/10.1172/jci33622} } @article{pappolla2003-12874399, author = {Pappolla, M. A. and Bryant-Thomas, T. K. and Herbert, D. and Pacheco, J. and Fabra Garcia, M. and Manjon, M. and Girones, X. and Henry, T. L. and others}, title = {{Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology}}, journal = {Neurology}, year = {2003}, doi = {10.1212/01.wnl.0000070182.02537.84}, pmid = {12874399}, url = {https://doi.org/10.1212/01.wnl.0000070182.02537.84} } @article{martins2005-16380608, author = {Martins, C. A. and Oulhaj, A. and de Jager, C. A. and Williams, J. H.}, title = {{APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model}}, journal = {Neurology}, year = {2005}, doi = {10.1212/01.wnl.0000188871.74093.12}, pmid = {16380608}, url = {https://doi.org/10.1212/01.wnl.0000188871.74093.12} } @article{cruchaga2011-21220649, author = {Cruchaga, C. and Graff, C. and Chiang, H. H. and Wang, J. and Hinrichs, A. L. and Spiegel, N. and Bertelsen, S. and Mayo, K. and others}, title = {{Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2010.350}, pmid = {21220649}, url = {https://doi.org/10.1001/archneurol.2010.350} } @article{bellenguez2017-28789839, author = {Bellenguez, C. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Le Guennec, K. and Nicolas, G. and Chauhan, G. and Wallon, D. and others}, title = {{Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls}}, journal = {Neurobiology of aging}, year = {2017}, doi = {10.1016/j.neurobiolaging.2017.07.001}, pmid = {28789839}, url = {https://doi.org/10.1016/j.neurobiolaging.2017.07.001} } @article{huynh2019-31623648, author = {Huynh, T. V. and Wang, C. and Tran, A. C. and Tabor, G. T. and Mahan, T. E. and Francis, C. M. and Finn, M. B. and Spellman, R. and others}, title = {{Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-019-0337-1}, pmid = {31623648}, url = {https://doi.org/10.1186/s13024-019-0337-1} } @article{yassine2017-28114437, author = {Yassine, H. N. and Braskie, M. N. and Mack, W. J. and Castor, K. J. and Fonteh, A. N. and Schneider, L. S. and Harrington, M. G. and Chui, H. C.}, title = {{Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers: A Review}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2016.4899}, pmid = {28114437}, url = {https://doi.org/10.1001/jamaneurol.2016.4899} } @article{caselli2007-17846270, author = {Caselli, R. J. and Reiman, E. M. and Locke, D. E. and Hutton, M. L. and Hentz, J. G. and Hoffman-Snyder, C. and Woodruff, B. K. and Alexander, G. E. and others}, title = {{Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment}}, journal = {Archives of neurology}, year = {2007}, doi = {10.1001/archneur.64.9.1306}, pmid = {17846270}, url = {https://doi.org/10.1001/archneur.64.9.1306} } @article{wingo2019-31135820, author = {Wingo, T. S. and Cutler, D. J. and Wingo, A. P. and Le, N. A. and Rabinovici, G. D. and Miller, B. L. and Lah, J. J. and Levey, A. I.}, title = {{Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2019.0648}, pmid = {31135820}, url = {https://doi.org/10.1001/jamaneurol.2019.0648} } @article{farrell2018-30305451, author = {Farrell, M. E. and Chen, X. and Rundle, M. M. and Chan, M. Y. and Wig, G. S. and Park, D. C.}, title = {{Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006469}, pmid = {30305451}, url = {https://doi.org/10.1212/wnl.0000000000006469} } @article{lazaro2025-41022152, author = {Lázaro, Iolanda and Brugulat‐Serrat, Anna and Suárez‐Calvet, Marc and Fauria, Karine and Minguillón, Carolina and Gispert, Juan Domingo and Molinuevo, José Luís and Harris, William S. and others}, title = {{Red blood cell ω-3 status and longitudinal cognition in individuals at risk of Alzheimer disease}}, journal = {Journal of Nutrition}, year = {2025}, doi = {10.1016/j.tjnut.2025.09.032}, pmid = {41022152}, url = {https://doi.org/10.1016/j.tjnut.2025.09.032} } @article{bales1997-9354781, author = {Bales, Kelly R. and Verina, Tatyana and Dodel, Richard C. and Du, Yansheng and Altstiel, Larry D. and Bender, Mark H. and Hyslop, Paul A. and Johnstone, Edward M. and Little, Sheila P. and Cummins, David J. and Piccardo, Pedro and Ghetti, Bernardino Francesco and Paul, Steven M.}, title = {{Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition}}, journal = {Nature Genetics}, year = {1997}, doi = {10.1038/ng1197-263}, pmid = {9354781}, url = {https://doi.org/10.1038/ng1197-263} } @article{sun2026-42066773, author = {Sun, X. and Mews, M. and Wheeler, N. R. and Benchek, P. and Gu, T. and Gomez, L. and Ray, N. and Reitz, C. and Naj, A. C. and Below, J. E. and Tosto, G. and Cornejo-Olivas, M. and others}, title = {{Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease}}, journal = {American Journal of Human Genetics}, year = {2026}, doi = {10.1016/j.ajhg.2026.04.007}, pmid = {42066773}, url = {https://doi.org/10.1016/j.ajhg.2026.04.007} } @article{thomassen2026-42736378, author = {Thomassen, J. Q. and Leonard, H. and Ulms, B. and Grenier-Boley, B. and Heikkinen, S. and Garcia-González, P. and Castillo-Morales, A. and Kikuchi, M. and Gim, J. and Cao, H. and Küçükali, F. and Amin, N. and others}, title = {{APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease}}, journal = {Nature genetics}, year = {2026}, doi = {10.1038/s41588-026-02713-9}, pmid = {42736378}, url = {https://doi.org/10.1038/s41588-026-02713-9} } @article{mahley2016-27174096, author = {Mahley, R. W.}, title = {{Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism}}, journal = {Arteriosclerosis, thrombosis, and vascular biology}, year = {2016}, doi = {10.1161/atvbaha.116.307023}, pmid = {27174096}, url = {https://doi.org/10.1161/atvbaha.116.307023} } @article{jun2010-20697030, author = {Jun, G. and Naj, A. C. and Beecham, G. W. and Wang, L. S. and Buros, J. and Gallins, P. J. and Buxbaum, J. D. and Ertekin-Taner, N. and others}, title = {{Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes}}, journal = {Archives of neurology}, year = {2010}, doi = {10.1001/archneurol.2010.201}, pmid = {20697030}, url = {https://doi.org/10.1001/archneurol.2010.201} } @article{matsuzaki2010-20739649, author = {Matsuzaki, T. and Sasaki, K. and Tanizaki, Y. and Hata, J. and Fujimi, K. and Matsui, Y. and Sekita, A. and Suzuki, S. O. and others}, title = {{Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181eee25f}, pmid = {20739649}, url = {https://doi.org/10.1212/wnl.0b013e3181eee25f} } @article{bondi2005-15699382, author = {Bondi, M. W. and Houston, W. S. and Eyler, L. T. and Brown, G. G.}, title = {{fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease}}, journal = {Neurology}, year = {2005}, doi = {10.1212/01.wnl.0000150885.00929.7e}, pmid = {15699382}, url = {https://doi.org/10.1212/01.wnl.0000150885.00929.7e} } @article{youmans2012-23060451, author = {Youmans, K. L. and Tai, L. M. and Nwabuisi-Heath, E. and Jungbauer, L. and Kanekiyo, T. and Gan, M. and Kim, J. and Eimer, W. A. and others}, title = {{APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease}}, journal = {The Journal of biological chemistry}, year = {2012}, doi = {10.1074/jbc.m112.407957}, pmid = {23060451}, url = {https://doi.org/10.1074/jbc.m112.407957} } @article{claes2021-34301296, author = {Claes, C. and Danhash, E. P. and Hasselmann, J. and Chadarevian, J. P. and Shabestari, S. K. and England, W. E. and Lim, T. E. and Hidalgo, J. L. S. and others}, title = {{Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2021}, doi = {10.1186/s13024-021-00473-0}, pmid = {34301296}, url = {https://doi.org/10.1186/s13024-021-00473-0} } @article{holstege2017-28537274, author = {Holstege, H. and van der Lee, S. J. and Hulsman, M. and Wong, T. H. and van Rooij, J. G. and Weiss, M. and Louwersheimer, E. and Wolters, F. J. and others}, title = {{Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy}}, journal = {European journal of human genetics : EJHG}, year = {2017}, doi = {10.1038/ejhg.2017.87}, pmid = {28537274}, url = {https://doi.org/10.1038/ejhg.2017.87} } @article{berlau2009-19255410, author = {Berlau, D. J. and Corrada, M. M. and Head, E. and Kawas, C. H.}, title = {{APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old}}, journal = {Neurology}, year = {2009}, doi = {10.1212/01.wnl.0000343853.00346.a4}, pmid = {19255410}, url = {https://doi.org/10.1212/01.wnl.0000343853.00346.a4} } @article{tai2013-23293020, author = {Tai, L. M. and Bilousova, T. and Jungbauer, L. and Roeske, S. K. and Youmans, K. L. and Yu, C. and Poon, W. W. and Cornwell, L. B. and others}, title = {{Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples}}, journal = {The Journal of biological chemistry}, year = {2013}, doi = {10.1074/jbc.m112.442103}, pmid = {23293020}, url = {https://doi.org/10.1074/jbc.m112.442103} } @article{wadhwani2019-30840313, author = {Wadhwani, A. R. and Affaneh, A. and Van Gulden, S. and Kessler, J. A.}, title = {{Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease}}, journal = {Annals of neurology}, year = {2019}, doi = {10.1002/ana.25455}, pmid = {30840313}, url = {https://doi.org/10.1002/ana.25455} } @article{oveisgharan2025-40845264, author = {Oveisgharan, Shahram and Yu, Lei and Yang, Jingyun and Agrawal, Sonal and Vialle, Ricardo A. and Lopes, Kátia de Paiva and Tasaki, Shinya and Wang, Yanling and others}, title = {{Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000214024}, pmid = {40845264}, url = {https://doi.org/10.1212/wnl.0000000000214024} } @article{haney2024-38480892, author = {Haney, M. S. and Pálovics, R. and Munson, C. N. and Long, C. and Johansson, P. K. and Yip, O. and Dong, W. and Rawat, E. and others}, title = {{APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia}}, journal = {Nature}, year = {2024}, doi = {10.1038/s41586-024-07185-7}, pmid = {38480892}, url = {https://doi.org/10.1038/s41586-024-07185-7} } @article{trigo2024-38312530, author = {Trigo, Arturo Nicolás and Muzzio, Marina and Figueroa, Marcelo Isidro and Alfaro-Gómez, Emma Laura and Bailliet, Graciela and Dopazo, Hernán Javier and Dipierri, José Edgardo}, title = {{Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina}}, journal = {Journal of Alzheimer's disease reports}, year = {2024}, doi = {10.3233/adr-230061}, pmid = {38312530}, url = {https://doi.org/10.3233/adr-230061} } @article{greenberg1995-7654074, author = {Greenberg, Steven Mark and Rebeck, George William and Vonsattel, Jean Paul and Gómez‐Isla, Teresa and Hyman, Bradley T.}, title = {{Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy}}, journal = {Annals of Neurology}, year = {1995}, doi = {10.1002/ana.410380219}, pmid = {7654074}, url = {https://doi.org/10.1002/ana.410380219} } @article{cahuapablo2015-aa9d6443, author = {Cahua-Pablo, Gabriel and Cruz, Miguel and del Moral-Hernández, Oscar and Leyva-Vázquez, Marco A. and Antúnez-Ortiz, Diana L. and Cahua-Pablo, José A. and Alarcón-Romero, Luz del Carmen and Ortuño-Pineda, Carlos and others}, title = {{Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene}}, journal = {Clinical and Applied Thrombosis/Hemostasis}, year = {2015}, doi = {10.1177/1076029614568714}, url = {https://doi.org/10.1177/1076029614568714} } @article{strittmatter1994-7972031, author = {Strittmatter, W. J. and Saunders, A. M. and Goedert, M. and Weisgraber, K. H. and Dong, L. M. and Jakes, R. and Huang, D. Y. and Pericak-Vance, M. and others}, title = {{Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1994}, doi = {10.1073/pnas.91.23.11183}, pmid = {7972031}, url = {https://doi.org/10.1073/pnas.91.23.11183} } @article{wahrle2005-16207708, author = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Hartman, R. E. and Bales, K. R. and Paul, S. M. and Holtzman, D. M.}, title = {{Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m508780200}, pmid = {16207708}, url = {https://doi.org/10.1074/jbc.m508780200} } @article{evans1995-7846048, author = {Evans, K. C. and Berger, E. P. and Cho, C. G. and Weisgraber, K. H. and Lansbury, P. T.}, title = {{Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1995}, doi = {10.1073/pnas.92.3.763}, pmid = {7846048}, url = {https://doi.org/10.1073/pnas.92.3.763} } @article{vanderwalt2004-15234467, author = {van der Walt, J. M. and Dementieva, Y. A. and Martin, E. R. and Scott, W. K. and Nicodemus, K. K. and Kroner, C. C. and Welsh-Bohmer, K. A. and Saunders, A. M. and others}, title = {{Analysis of European mitochondrial haplogroups with Alzheimer disease risk}}, journal = {Neuroscience letters}, year = {2004}, doi = {10.1016/j.neulet.2004.04.051}, pmid = {15234467}, url = {https://doi.org/10.1016/j.neulet.2004.04.051} } @article{beecham2009-19118814, author = {Beecham, G. W. and Martin, E. R. and Li, Y. J. and Slifer, M. A. and Gilbert, JR. and Haines, J. L. and Pericak-Vance, M. A.}, title = {{Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease}}, journal = {American journal of human genetics}, year = {2009}, doi = {10.1016/j.ajhg.2008.12.008}, pmid = {19118814}, url = {https://doi.org/10.1016/j.ajhg.2008.12.008} } @article{butterfield2020-32036033, author = {Butterfield, D. A. and Mattson, M. P.}, title = {{Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease}}, journal = {Neurobiology of disease}, year = {2020}, doi = {10.1016/j.nbd.2020.104795}, pmid = {32036033}, url = {https://doi.org/10.1016/j.nbd.2020.104795} } @article{persson2006-16606914, author = {Persson, J. and Lind, J. and Larsson, A. and Ingvar, M. and Cruts, M. and Van Broeckhoven, C. and Adolfsson, R. and Nilsson, L. G. and others}, title = {{Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000204180.25361.48}, pmid = {16606914}, url = {https://doi.org/10.1212/01.wnl.0000204180.25361.48} } @article{nelson2013-23771217, author = {Nelson, P. T. and Pious, N. M. and Jicha, G. A. and Wilcock, D. M. and Fardo, D. W. and Estus, S. and Rebeck, G. W.}, title = {{APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature}}, journal = {Journal of neuropathology and experimental neurology}, year = {2013}, doi = {10.1097/nen.0b013e31829a25b9}, pmid = {23771217}, url = {https://doi.org/10.1097/nen.0b013e31829a25b9} } @article{takei2009-19442637, author = {Takei, N. and Miyashita, A. and Tsukie, T. and Arai, H. and Asada, T. and Imagawa, M. and Shoji, M. and Higuchi, S. and others}, title = {{Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese}}, journal = {Genomics}, year = {2009}, doi = {10.1016/j.ygeno.2009.01.003}, pmid = {19442637}, url = {https://doi.org/10.1016/j.ygeno.2009.01.003} } @article{olichney2000-10867785, author = {Olichney, J. M. and Hansen, L. A. and Hofstetter, C. R. and Lee, J. H. and Katzman, R. and Thal, L. J.}, title = {{Association between severe cerebral amyloid angiopathy and cerebrovascular lesions in Alzheimer disease is not a spurious one attributable to apolipoprotein E4}}, journal = {Archives of neurology}, year = {2000}, doi = {10.1001/archneur.57.6.869}, pmid = {10867785}, url = {https://doi.org/10.1001/archneur.57.6.869} } @article{kerchner2014-24453080, author = {Kerchner, G. A. and Berdnik, D. and Shen, J. C. and Bernstein, J. D. and Fenesy, M. C. and Deutsch, G. K. and Wyss-Coray, T. and Rutt, B. K.}, title = {{APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000154}, pmid = {24453080}, url = {https://doi.org/10.1212/wnl.0000000000000154} } @article{caselli2011-21502596, author = {Caselli, R. J. and Dueck, A. C. and Locke, D. E. and Hoffman-Snyder, C. R. and Woodruff, B. K. and Rapcsak, S. Z. and Reiman, E. M.}, title = {{Longitudinal modeling of frontal cognition in APOE ε4 homozygotes, heterozygotes, and noncarriers}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e3182167147}, pmid = {21502596}, url = {https://doi.org/10.1212/wnl.0b013e3182167147} } @article{sasaki1998-9777946, author = {Sasaki, N. and Fukatsu, R. and Tsuzuki, K. and Hayashi, Y. and Yoshida, T. and Fujii, N. and Koike, T. and Wakayama, I. and others}, title = {{Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases}}, journal = {The American journal of pathology}, year = {1998}, doi = {10.1016/s0002-9440(10)65659-3}, pmid = {9777946}, url = {https://doi.org/10.1016/s0002-9440(10)65659-3} } @article{martin2000-10869235, author = {Martin, E. R. and Lai, E. H. and Gilbert, JR. and Rogala, A. R. and Afshari, A. J. and Riley, J. and Finch, K. L. and Stevens, J. F. and others}, title = {{SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease}}, journal = {American journal of human genetics}, year = {2000}, doi = {10.1086/303003}, pmid = {10869235}, url = {https://doi.org/10.1086/303003} } @article{corder1998-9771753, author = {Corder, E. H. and Robertson, K. and Lannfelt, L. and Bogdanovic, N. and Eggertsen, G. and Wilkins, J. and Hall, C.}, title = {{HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy}}, journal = {Nature medicine}, year = {1998}, doi = {10.1038/2677}, pmid = {9771753}, url = {https://doi.org/10.1038/2677} } @article{chen2011-21118811, author = {Chen, H. K. and Ji, Z. S. and Dodson, S. E. and Miranda, R. D. and Rosenblum, C. I. and Reynolds, I. J. and Freedman, S. B. and Weisgraber, K. H. and others}, title = {{Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease}}, journal = {The Journal of biological chemistry}, year = {2011}, doi = {10.1074/jbc.m110.151084}, pmid = {21118811}, url = {https://doi.org/10.1074/jbc.m110.151084} } @article{buttini2002-12486146, author = {Buttini, M. and Yu, G. Q. and Shockley, K. and Huang, Y. and Jones, B. and Masliah, E. and Mallory, M. and Yeo, T. and others}, title = {{Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2002}, doi = {10.1523/jneurosci.22-24-10539.2002}, pmid = {12486146}, url = {https://doi.org/10.1523/jneurosci.22-24-10539.2002} } @article{diazarrastia2003-12810485, author = {Diaz-Arrastia, R. and Gong, Y. and Fair, S. and Scott, K. D. and Garcia, M. C. and Carlile, M. C. and Agostini, M. A. and Van Ness, P. C.}, title = {{Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele}}, journal = {Archives of neurology}, year = {2003}, doi = {10.1001/archneur.60.6.818}, pmid = {12810485}, url = {https://doi.org/10.1001/archneur.60.6.818} } @article{beeri2006-16682673, author = {Beeri, M. S. and Rapp, M. and Silverman, J. M. and Schmeidler, J. and Grossman, H. T. and Fallon, J. T. and Purohit, D. P. and Perl, D. P. and others}, title = {{Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000210447.19748.0b}, pmid = {16682673}, url = {https://doi.org/10.1212/01.wnl.0000210447.19748.0b} } @article{westlye2012-23100402, author = {Westlye, L. T. and Reinvang, I. and Rootwelt, H. and Espeseth, T.}, title = {{Effects of APOE on brain white matter microstructure in healthy adults}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182735c9c}, pmid = {23100402}, url = {https://doi.org/10.1212/wnl.0b013e3182735c9c} } @article{zhang2025-41404739, author = {Zhang, Chong‐Hui and Huang, Liang‐Yu and Feng, Yu‐Gong and Tan, Chen‐Chen and Tan, Lan and Xu, Wei}, title = {{APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms}}, journal = {Journal of the American Heart Association}, year = {2025}, doi = {10.1161/jaha.125.043446}, pmid = {41404739}, url = {https://doi.org/10.1161/jaha.125.043446} } @article{poirier1993-8103819, author = {Poirier, J. and Davignon, J. and Bouthillier, D. and Kogan, S. and Bertrand, P. and Gauthier, S.}, title = {{Apolipoprotein E polymorphism and Alzheimer's disease}}, journal = {Lancet (London, England)}, year = {1993}, doi = {10.1016/0140-6736(93)91705-q}, pmid = {8103819}, url = {https://doi.org/10.1016/0140-6736(93)91705-q} } @article{zhang2022-35915083, author = {Zhang, Hongsheng and Shao, Lin and Lin, Zhihao and Long, Quan-Xin and Yuan, Huilong and Cai, Lujian and Jiang, Guangtong and Guo, Xiaoyi and others}, title = {{APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients}}, journal = {Signal transduction and targeted therapy}, year = {2022}, doi = {10.1038/s41392-022-01118-4}, pmid = {35915083}, url = {https://doi.org/10.1038/s41392-022-01118-4} } @article{kadir2026-42744302, author = {Kadir, Rais Reskiawan A and Bons, Joanna and Hormazabal, Genesis Vega and Kumaar, Prasanna Vadhana Ashok and Gerónimo-Olvera, Cristian and Tshilenge, Kizito-Tshitoko and Pihán, Philippe and Aguirre, Carlos Galicia and others}, title = {{The longevity gene APOE2 enhances pericyte function and reduces lipid droplets}}, journal = {Brain : a journal of neurology}, year = {2026}, doi = {10.1093/brain/awag311}, pmid = {42744302}, url = {https://doi.org/10.1093/brain/awag311} } @article{cunilopez2026-42749735, author = {Cuní-López, Carla and Root, Jessica T and Hao, Ying and Blomberg, Niek and Hertog, Sascha J Koppes-den and Sacks, Dylan and Trujillo, Amber E and Ghirlando, Rodolfo and others}, title = {{APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics}}, journal = {Nature communications}, year = {2026}, doi = {10.1038/s41467-026-76565-6}, pmid = {42749735}, url = {https://doi.org/10.1038/s41467-026-76565-6} } @article{blacker1997-9008509, author = {Blacker, Deborah and Haines, Jonathan L. and Rodes, L. and Terwedow, Henry A and Go, Rodney C.P. and Harrell, L. E. and Perry, Rodney T. and Bassett, Susan Spear and others}, title = {{ApoE-4 and Age at Onset of Alzheimer's Disease}}, journal = {Neurology}, year = {1997}, doi = {10.1212/wnl.48.1.139}, pmid = {9008509}, url = {https://doi.org/10.1212/wnl.48.1.139} } @article{chartierharlin1994-8069300, author = {Chartier‐Harlin, Marie‐Christine and Parfitt, Matthew and Legrain, Sylvie and Pérez‐Tur, Jordi and Brousseau, Thierry and Evans, Alun and Berr, Claudine and Vldal, Odile and others}, title = {{Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region}}, journal = {Human Molecular Genetics}, year = {1994}, doi = {10.1093/hmg/3.4.569}, pmid = {8069300}, url = {https://doi.org/10.1093/hmg/3.4.569} } @article{uyrum2015-153a84d1, author = {Uyrum, Ebru and Balbay, Oner and Annakkaya, Ali Nihat and Balbay, Ege Gulec and Silan, Fatma and Arbak, Peri}, title = {{The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants}}, journal = {Respiration}, year = {2015}, doi = {10.1159/000369560}, url = {https://doi.org/10.1159/000369560} } @article{koldamova2005-16207713, author = {Koldamova, R. and Staufenbiel, M. and Lefterov, I.}, title = {{Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m504513200}, pmid = {16207713}, url = {https://doi.org/10.1074/jbc.m504513200} } @article{zlokovic2013-23400708, author = {Zlokovic, B. V.}, title = {{Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.2152}, pmid = {23400708}, url = {https://doi.org/10.1001/jamaneurol.2013.2152} } @article{bondi1995-8848194, author = {Bondi, M. W. and Salmon, D. P. and Monsch, A. U. and Galasko, D. and Butters, N. and Klauber, M. R. and Thal, L. J. and Saitoh, T.}, title = {{Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults}}, journal = {Neurology}, year = {1995}, doi = {10.1212/wnl.45.12.2203}, pmid = {8848194}, url = {https://doi.org/10.1212/wnl.45.12.2203} } @article{hirschreinshagen2005-16207707, author = {Hirsch-Reinshagen, V. and Maia, L. F. and Burgess, B. L. and Blain, J. F. and Naus, K. E. and McIsaac, S. A. and Parkinson, P. F. and Chan, J. Y. and others}, title = {{The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m508781200}, pmid = {16207707}, url = {https://doi.org/10.1074/jbc.m508781200} } @article{li2012-23132858, author = {Li, J. and Kanekiyo, T. and Shinohara, M. and Zhang, Y. and LaDu, M. J. and Xu, H. and Bu, G.}, title = {{Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms}}, journal = {The Journal of biological chemistry}, year = {2012}, doi = {10.1074/jbc.m112.420224}, pmid = {23132858}, url = {https://doi.org/10.1074/jbc.m112.420224} } @article{lee2012-22130662, author = {Lee, C. Y. and Tse, W. and Smith, J. D. and Landreth, G. E.}, title = {{Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels}}, journal = {The Journal of biological chemistry}, year = {2012}, doi = {10.1074/jbc.m111.295451}, pmid = {22130662}, url = {https://doi.org/10.1074/jbc.m111.295451} } @article{mccarron1999-10411341, author = {McCarron, M. O. and Nicoll, J. A. and Stewart, J. and Ironside, J. W. and Mann, D. M. and Love, S. and Graham, D. I. and Dewar, D.}, title = {{The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage}}, journal = {Journal of neuropathology and experimental neurology}, year = {1999}, doi = {10.1097/00005072-199907000-00005}, pmid = {10411341}, url = {https://doi.org/10.1097/00005072-199907000-00005} } @article{satoh2015-26260791, author = {Satoh, K. and Abe-Dohmae, S. and Yokoyama, S. and St George-Hyslop, P. and Fraser, P. E.}, title = {{ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing}}, journal = {The Journal of biological chemistry}, year = {2015}, doi = {10.1074/jbc.m115.655076}, pmid = {26260791}, url = {https://doi.org/10.1074/jbc.m115.655076} } @article{olsson2003-12957490, author = {Olsson, A. and Höglund, K. and Sjögren, M. and Andreasen, N. and Minthon, L. and Lannfelt, L. and Buerger, K. and Möller, H. J. and others}, title = {{Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients}}, journal = {Experimental neurology}, year = {2003}, doi = {10.1016/s0014-4886(03)00027-x}, pmid = {12957490}, url = {https://doi.org/10.1016/s0014-4886(03)00027-x} } @article{peskind2006-16831961, author = {Peskind, E. R. and Li, G. and Shofer, J. and Quinn, J. F. and Kaye, J. A. and Clark, C. M. and Farlow, M. R. and DeCarli, C. and others}, title = {{Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition}}, journal = {Archives of neurology}, year = {2006}, doi = {10.1001/archneur.63.7.936}, pmid = {16831961}, url = {https://doi.org/10.1001/archneur.63.7.936} } @article{drzezga2005-15642911, author = {Drzezga, A. and Riemenschneider, M. and Strassner, B. and Grimmer, T. and Peller, M. and Knoll, A. and Wagenpfeil, S. and Minoshima, S. and others}, title = {{Cerebral glucose metabolism in patients with AD and different APOE genotypes}}, journal = {Neurology}, year = {2005}, doi = {10.1212/01.wnl.0000148478.39691.d3}, pmid = {15642911}, url = {https://doi.org/10.1212/01.wnl.0000148478.39691.d3} } @article{pan2019-31597550, author = {Pan, Y. and Li, H. and Wang, Y. and Meng, X.}, title = {{Causal Effect of Lp(a) [Lipoprotein(a)] Level on Ischemic Stroke and Alzheimer Disease: A Mendelian Randomization Study}}, journal = {Stroke}, year = {2019}, doi = {10.1161/strokeaha.119.026872}, pmid = {31597550}, url = {https://doi.org/10.1161/strokeaha.119.026872} } @article{krogsaeter2025-41103078, author = {Krogsaeter, Einar Kleinhans and McKetney, Justin and Valiente‐Banuet, Leopoldo and Marquez, Angelica and Willis, Alexandra R. and Cakir, Zeynep and Stevenson, Erica J. and Jang, Gwendolyn Μ. and others}, title = {{Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction}}, journal = {Autophagy}, year = {2025}, doi = {10.1080/15548627.2025.2576613}, pmid = {41103078}, url = {https://doi.org/10.1080/15548627.2025.2576613} } @article{drzezga2009-19339712, author = {Drzezga, A. and Grimmer, T. and Henriksen, G. and Mühlau, M. and Perneczky, R. and Miederer, I. and Praus, C. and Sorg, C. and others}, title = {{Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181a2e8d0}, pmid = {19339712}, url = {https://doi.org/10.1212/wnl.0b013e3181a2e8d0} } @article{parcon2018-28945989, author = {Parcon, P. A. and Balasubramaniam, M. and Ayyadevara, S. and Jones, R. A. and Liu, L. and Shmookler Reis, R. J. and Barger, S. W. and Mrak, R. E. and others}, title = {{Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2018}, doi = {10.1016/j.jalz.2017.07.754}, pmid = {28945989}, url = {https://doi.org/10.1016/j.jalz.2017.07.754} } @article{reed1994-7986172, author = {Reed, T. and Carmelli, D. and Swan, G. E. and Breitner, J. C. and Welsh, K. A. and Jarvik, G. P. and Deeb, S. and Auwerx, J.}, title = {{Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele}}, journal = {Archives of neurology}, year = {1994}, doi = {10.1001/archneur.1994.00540240033012}, pmid = {7986172}, url = {https://doi.org/10.1001/archneur.1994.00540240033012} } @article{jun2012-22869155, author = {Jun, G. and Vardarajan, B. N. and Buros, J. and Yu, C. E. and Hawk, M. V. and Dombroski, B. A. and Crane, P. K. and Larson, E. B. and others}, title = {{Comprehensive search for Alzheimer disease susceptibility loci in the APOE region}}, journal = {Archives of neurology}, year = {2012}, doi = {10.1001/archneurol.2012.2052}, pmid = {22869155}, url = {https://doi.org/10.1001/archneurol.2012.2052} } @article{ikonomovic2011-21700583, author = {Ikonomovic, M. D. and Klunk, W. E. and Abrahamson, E. E. and Wuu, J. and Mathis, C. A. and Scheff, S. W. and Mufson, E. J. and DeKosky, S. T.}, title = {{Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e3182231419}, pmid = {21700583}, url = {https://doi.org/10.1212/wnl.0b013e3182231419} } @article{vanderlip2025-40577676, author = {Vanderlip, Casey R. and Stark, Craig E.L.}, title = {{Time Course and Severity of Cognitive Changes as a Function of Aβ Positivity and APOE Genotype in Alzheimer Disease}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213853}, pmid = {40577676}, url = {https://doi.org/10.1212/wnl.0000000000213853} } @article{pandey2024-38676929, author = {Pandey, Ravi S and Arnold, Mattias and Batra, Richa and Krumsiek, Jan and Kotredes, Kevin P and Garceau, Dylan and Williams, Harriet and Sasner, Michael and others}, title = {{Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13851}, pmid = {38676929}, url = {https://doi.org/10.1002/alz.13851} } @article{golden2025-41219507, author = {Golden, Lesley R and Siano, Dahlia S and Stephens, Isaiah O and MacLean, Steven M and Saito, Kai and Nolt, Georgia L and Funnell, Jessica L and Pallerla, Akhil V and others}, title = {{APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related metabolic signatures, neuropathology and cognition}}, journal = {Nature neuroscience}, year = {2025}, doi = {10.1038/s41593-025-02094-y}, pmid = {41219507}, url = {https://doi.org/10.1038/s41593-025-02094-y} } @article{ning2024-38867189, author = {Ning, Zhiyuan and Liu, Ying and Wan, Mengyao and Zuo, You and Chen, Siqi and Shi, Zhongshan and Xu, Yongteng and Li, Honghong and others}, title = {{APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling}}, journal = {Cellular \& molecular biology letters}, year = {2024}, doi = {10.1186/s11658-024-00600-x}, pmid = {38867189}, url = {https://doi.org/10.1186/s11658-024-00600-x} } @article{sasayama2020-32426945, author = {Sasayama, Daimei and Hattori, Kotaro and Yokota, Yuuki and Matsumura, Ryo and Teraishi, Toshiya and Yoshida, Sumiko and Kunugi, Hiroshi}, title = {{Increased apolipoprotein E and decreased TNF-α in the cerebrospinal fluid of nondemented APOE-ε4 carriers}}, journal = {Neuropsychopharmacology reports}, year = {2020}, doi = {10.1002/npr2.12110}, pmid = {32426945}, url = {https://doi.org/10.1002/npr2.12110} } @article{kim2025-41288387, author = {Kim, Boyoung and Yuk, Minju and Park, Moonsu and Ryu, Hongji and Park, Junhang and Yu, Hyerin and Park, Sungsoo and Hong, Jin Tae and others}, title = {{CRISPR editing of miR-33 restores ApoE lipidation and amyloid-β metabolism in ApoE4 sporadic Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2025}, doi = {10.1093/brain/awaf244}, pmid = {41288387}, url = {https://doi.org/10.1093/brain/awaf244} } @article{ostendorf2022-36130725, author = {Ostendorf, Benjamin N and Patel, Mira A and Bilanovic, Jana and Hoffmann, H-Heinrich and Carrasco, Sebastian E and Rice, Charles M and Tavazoie, Sohail F}, title = {{Common human genetic variants of APOE impact murine COVID-19 mortality}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-05344-2}, pmid = {36130725}, url = {https://doi.org/10.1038/s41586-022-05344-2} } @article{smelt2004-15630634, author = {Smelt, A H M and de Beer, F}, title = {{Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects}}, journal = {Seminars in vascular medicine}, year = {2004}, doi = {10.1055/s-2004-861492}, pmid = {15630634}, url = {https://doi.org/10.1055/s-2004-861492} } @article{liu2025-41436721, author = {Liu, Chan and Liu, Juan and Wang, Yan-Yang and Xu, Shang-Fu and Yu, Li-Mei}, title = {{APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer's Disease and Cardiovascular Disease}}, journal = {Molecular neurobiology}, year = {2025}, doi = {10.1007/s12035-025-05629-3}, pmid = {41436721}, url = {https://doi.org/10.1007/s12035-025-05629-3} } @article{abhyankar2025-39749840, author = {Abhyankar, Surabhi D and Luo, Qianyi and Hartman, Gabriella D and Mahajan, Neha and Corson, Timothy W and Oblak, Adrian L and Lamb, Bruce T and Bhatwadekar, Ashay D}, title = {{Retinal dysfunction in APOE4 knock-in mouse model of Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.14433}, pmid = {39749840}, url = {https://doi.org/10.1002/alz.14433} } @article{bis2020-30108311, author = {Bis, J. C. and Jian, X. and Kunkle, B. W. and Chen, Y. and Hamilton-Nelson, K. L. and Bush, W. S. and Salerno, W. J. and Lancour, D. and others}, title = {{Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation}}, journal = {Molecular psychiatry}, year = {2020}, doi = {10.1038/s41380-018-0112-7}, pmid = {30108311}, url = {https://doi.org/10.1038/s41380-018-0112-7} } @article{tsai1994-8128961, author = {Tsai, M. S. and Tangalos, E. G. and Petersen, R. C. and Smith, G. E. and Schaid, D. J. and Kokmen, E. and Ivnik, R. J. and Thibodeau, S. N.}, title = {{Apolipoprotein E: risk factor for Alzheimer disease}}, journal = {American journal of human genetics}, year = {1994}, pmid = {8128961} } @article{ramassamy1999-10490274, author = {Ramassamy, C. and Averill, D. and Beffert, U. and Bastianetto, S. and Theroux, L. and Lussier-Cacan, S. and Cohn, J. S. and Christen, Y. and others}, title = {{Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype}}, journal = {Free radical biology \& medicine}, year = {1999}, doi = {10.1016/s0891-5849(99)00102-1}, pmid = {10490274}, url = {https://doi.org/10.1016/s0891-5849(99)00102-1} } @article{sato2015-26557086, author = {Sato, N. and Morishita, R.}, title = {{The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease}}, journal = {Frontiers in aging neuroscience}, year = {2015}, doi = {10.3389/fnagi.2015.00199}, pmid = {26557086}, url = {https://doi.org/10.3389/fnagi.2015.00199} } @article{dodson2006-16957580, author = {Dodson, S. E. and Gearing, M. and Lippa, C. F. and Montine, T. J. and Levey, A. I. and Lah, J. J.}, title = {{LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease}}, journal = {Journal of neuropathology and experimental neurology}, year = {2006}, doi = {10.1097/01.jnen.0000228205.19915.20}, pmid = {16957580}, url = {https://doi.org/10.1097/01.jnen.0000228205.19915.20} } @article{johnson2006-16738250, author = {Johnson, S. C. and Schmitz, T. W. and Trivedi, M. A. and Ries, M. L. and Torgerson, B. M. and Carlsson, C. M. and Asthana, S. and Hermann, B. P. and others}, title = {{The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2006}, doi = {10.1523/jneurosci.0959-06.2006}, pmid = {16738250}, url = {https://doi.org/10.1523/jneurosci.0959-06.2006} } @article{whalley2008-18258638, author = {Whalley, L. J. and Deary, I. J. and Starr, J. M. and Wahle, K. W. and Rance, K. A. and Bourne, V. J. and Fox, H. C.}, title = {{n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood}}, journal = {The American journal of clinical nutrition}, year = {2008}, doi = {10.1093/ajcn/87.2.449}, pmid = {18258638}, url = {https://doi.org/10.1093/ajcn/87.2.449} } @article{gearing1994-7937774, author = {Gearing, M. and Rebeck, G. W. and Hyman, B. T. and Tigges, J. and Mirra, S. S.}, title = {{Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1994}, doi = {10.1073/pnas.91.20.9382}, pmid = {7937774}, url = {https://doi.org/10.1073/pnas.91.20.9382} } @article{lathe2014-24656052, author = {Lathe, R. and Sapronova, A. and Kotelevtsev, Y.}, title = {{Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature}}, journal = {BMC geriatrics}, year = {2014}, doi = {10.1186/1471-2318-14-36}, pmid = {24656052}, url = {https://doi.org/10.1186/1471-2318-14-36} } @article{ossenkoppele2013-23255822, author = {Ossenkoppele, R. and van der Flier, W. M. and Zwan, M. D. and Adriaanse, S. F. and Boellaard, R. and Windhorst, A. D. and Barkhof, F. and Lammertsma, A. A. and others}, title = {{Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia}}, journal = {Neurology}, year = {2013}, doi = {10.1212/wnl.0b013e31827f0889}, pmid = {23255822}, url = {https://doi.org/10.1212/wnl.0b013e31827f0889} } @article{uchihara1995-7478253, author = {Uchihara, T. and Duyckaerts, C. and He, Y. and Kobayashi, K. and Seilhean, D. and Amouyel, P. and Hauw, J. J.}, title = {{ApoE immunoreactivity and microglial cells in Alzheimer's disease brain}}, journal = {Neuroscience letters}, year = {1995}, doi = {10.1016/0304-3940(95)11763-m}, pmid = {7478253}, url = {https://doi.org/10.1016/0304-3940(95)11763-m} } @article{ponomareva2008-17293007, author = {Ponomareva, N. V. and Korovaitseva, G. I. and Rogaev, E. I.}, title = {{EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease}}, journal = {Neurobiology of aging}, year = {2008}, doi = {10.1016/j.neurobiolaging.2006.12.019}, pmid = {17293007}, url = {https://doi.org/10.1016/j.neurobiolaging.2006.12.019} } @article{blanchard2022-36385529, author = {Blanchard, J. W. and Akay, L. A. and Davila-Velderrain, J. and von Maydell, D. and Mathys, H. and Davidson, S. M. and Effenberger, A. and Chen, C. Y. and others}, title = {{APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes}}, journal = {Nature}, year = {2022}, doi = {10.1038/s41586-022-05439-w}, pmid = {36385529}, url = {https://doi.org/10.1038/s41586-022-05439-w} } @article{cruchaga2012-22821396, author = {Cruchaga, C. and Kauwe, J. S. and Nowotny, P. and Bales, K. and Pickering, E. H. and Mayo, K. and Bertelsen, S. and Hinrichs, A. and others}, title = {{Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease}}, journal = {Human molecular genetics}, year = {2012}, doi = {10.1093/hmg/dds296}, pmid = {22821396}, url = {https://doi.org/10.1093/hmg/dds296} } @article{ralhan2026-41338186, author = {Ralhan, Isha and Do, Alison D and Bae, Ju-Young and Feringa, Femke M and Cai, Wendy and Chang, Jinlan and Chik, Kennedi and Lee, Nathanael Y J and others}, title = {{Protective ApoE variants support neuronal function by effluxing oxidized phospholipids}}, journal = {Neuron}, year = {2026}, doi = {10.1016/j.neuron.2025.10.040}, pmid = {41338186}, url = {https://doi.org/10.1016/j.neuron.2025.10.040} } @article{meneses2023-36546684, author = {Meneses, Axel D and Koga, Shunsuke and Li, Zonghua and O'Leary, Justin and Li, Fuyao and Chen, Kai and Murakami, Aya and Qiao, Wenhui and others}, title = {{APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology}}, journal = {Annals of neurology}, year = {2023}, doi = {10.1002/ana.26580}, pmid = {36546684}, url = {https://doi.org/10.1002/ana.26580} } @article{zhao2021-34453582, author = {Zhao, Jing and Lu, Wenyan and Ren, Yingxue and Fu, Yuan and Martens, Yuka A and Shue, Francis and Davis, Mary D and Wang, Xue and others}, title = {{Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids}}, journal = {Acta neuropathologica}, year = {2021}, doi = {10.1007/s00401-021-02361-9}, pmid = {34453582}, url = {https://doi.org/10.1007/s00401-021-02361-9} } @article{giannisis2022-35418601, author = {Giannisis, Andreas and Patra, Kalicharan and Edlund, Anna K and Nieto, Lur Agirrezabala and Benedicto-Gras, Joan and Moussaud, Simon and de la Rosa, Andrés and Twohig, Daniel and others}, title = {{Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice}}, journal = {Molecular psychiatry}, year = {2022}, doi = {10.1038/s41380-022-01548-0}, pmid = {35418601}, url = {https://doi.org/10.1038/s41380-022-01548-0} } @article{schurman2026-41972397, author = {Schurman, Charles A and Kaur, Gurcharan and Kaya, Serra and Bons, Joanna and Aguirre, Carlos Galicia and Liu, Qi and King, Christina D and Wilson, Kenneth A and others}, title = {{Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone}}, journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)}, year = {2026}, doi = {10.1002/advs.202523511}, pmid = {41972397}, url = {https://doi.org/10.1002/advs.202523511} } @article{geronimoolvera2026-42103698, author = {Gerónimo-Olvera, Cristian and Scheeler, Stephen M and Aguirre, Carlos Galicia and Vega-Hormazabal, Genesis and Garcia, Daniela and Wu, Long and Murad, Natalia and Schneider, Kevin and others}, title = {{Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons}}, journal = {Aging cell}, year = {2026}, doi = {10.1111/acel.70494}, pmid = {42103698}, url = {https://doi.org/10.1111/acel.70494} } @article{morris2016-27318141, author = {Morris, Jill K and Vidoni, Eric D and Wilkins, Heather M and Archer, Ashley E and Burns, Nicole C and Karcher, Rainer T and Graves, Rasinio S and Swerdlow, Russell H and others}, title = {{Impaired fasting glucose is associated with increased regional cerebral amyloid}}, journal = {Neurobiology of aging}, year = {2016}, doi = {10.1016/j.neurobiolaging.2016.04.017}, pmid = {27318141}, url = {https://doi.org/10.1016/j.neurobiolaging.2016.04.017} } @article{wang2015-e22ce2de, author = {Wang, Kai and Wang, Pei and Qiao, Yingjin and Lu, Xiaoqing and Wang, Xin and Liu, Zhangsuo}, title = {{The effects of serum apolipoprotein E genetic variants and concentration on serum lipid parameters in haemodialysis patients}}, journal = {Journal of Pharmacy and Pharmacology}, year = {2015}, doi = {10.1111/jphp.12356}, url = {https://doi.org/10.1111/jphp.12356} } @article{sun2015-f780dedc, author = {Sun, Shoudan and Fu, Jingming and Chen, Jun and Pang, Wei and Hu, Ruomei and Li, Haiqiang and Tan, Long and Jiang, Yugang}, title = {{ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China}}, journal = {American Journal of Alzheimer's Disease \& Other Dementias®}, year = {2015}, doi = {10.1177/1533317514566114}, url = {https://doi.org/10.1177/1533317514566114} } @article{gunaydin2024-39511891, author = {Günaydin, C. and Sondhi, D. and Kaminsky, S. M. and Lephart, H. C. and Leopold, P. L. and Hackett, N. R. and Khanna, R. and Crystal, R. G.}, title = {{AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer's disease mice}}, journal = {Molecular Therapy}, year = {2024}, doi = {10.1016/j.ymthe.2024.11.003}, pmid = {39511891}, url = {https://doi.org/10.1016/j.ymthe.2024.11.003} } @article{yu2007-17434289, author = {Yu, C. E. and Seltman, H. and Peskind, E. R. and Galloway, N. and Zhou, P. X. and Rosenthal, E. and Wijsman, E. M. and Tsuang, D. W. and others}, title = {{Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association}}, journal = {Genomics}, year = {2007}, doi = {10.1016/j.ygeno.2007.02.002}, pmid = {17434289}, url = {https://doi.org/10.1016/j.ygeno.2007.02.002} } @article{babin1997-9238027, author = {Babin, P. J. and Thisse, C. and Durliat, M. and Andre, M. and Akimenko, M. A. and Thisse, B.}, title = {{Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1997}, doi = {10.1073/pnas.94.16.8622}, pmid = {9238027}, url = {https://doi.org/10.1073/pnas.94.16.8622} } @article{poeggeler2001-11732920, author = {Poeggeler, B. and Miravalle, L. and Zagorski, M. G. and Wisniewski, T. and Chyan, Y. J. and Zhang, Y. and Shao, H. and Bryant-Thomas, T. and others}, title = {{Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide}}, journal = {Biochemistry}, year = {2001}, doi = {10.1021/bi0114269}, pmid = {11732920}, url = {https://doi.org/10.1021/bi0114269} } @article{west1994-7970208, author = {West, H. L. and Rebeck, G. W. and Hyman, B. T.}, title = {{Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease}}, journal = {Neuroscience letters}, year = {1994}, doi = {10.1016/0304-3940(94)91074-x}, pmid = {7970208}, url = {https://doi.org/10.1016/0304-3940(94)91074-x} } @article{moir1999-10194381, author = {Moir, R. D. and Atwood, C. S. and Romano, D. M. and Laurans, M. H. and Huang, X. and Bush, A. I. and Smith, J. D. and Tanzi, R. E.}, title = {{Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations}}, journal = {Biochemistry}, year = {1999}, doi = {10.1021/bi982437d}, pmid = {10194381}, url = {https://doi.org/10.1021/bi982437d} } @article{matsuzaki2011-21911734, author = {Matsuzaki, T. and Sasaki, K. and Hata, J. and Hirakawa, Y. and Fujimi, K. and Ninomiya, T. and Suzuki, S. O. and Kanba, S. and others}, title = {{Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e31822e145d}, pmid = {21911734}, url = {https://doi.org/10.1212/wnl.0b013e31822e145d} } @article{chen2025-40349252, author = {Chen, Jia‐Hung and Chan, Lung and Hong, Chien‐Tai and Hu, Chaur Jong and Hsieh, Yi‐Chen}, title = {{Role of apolipoprotein E (ApoE) ε4 in cognitive impairment after a stroke: a prospective cohort study}}, journal = {Aging}, year = {2025}, doi = {10.18632/aging.206248}, pmid = {40349252}, url = {https://doi.org/10.18632/aging.206248} } @article{caro2026-41906765, author = {Caro, Daniela Diaz and Rodriguez, Sophia and Uhlmann, Wendy R. and Goldman, Jill S. and McCain, Sarah and Wetmore, John Brandon and Caban, Maria L. and Chung, Wendy K. and others}, title = {{Exploring immediate responses to APOE ε 4/ε4 genotype and Alzheimer's disease risk disclosure in Latinos}}, journal = {Journal of Alzheimer s Disease}, year = {2026}, doi = {10.1177/13872877261435633}, pmid = {41906765}, url = {https://doi.org/10.1177/13872877261435633} } @article{holstege2025-41442609, author = {Holstege, Henne H. and Salazar, Alex and Knoop, Lydian and Pijnenburg, Yolande A.L. and van der Lee, Sven J and Wijesekera, Sanduni and Křížová, Jana and Hiltunen, Mikko O. and others}, title = {{Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_104407}, pmid = {41442609}, url = {https://doi.org/10.1002/alz70855_104407} } @article{cheng2025-fccc56a0, author = {Cheng, Bo and Feng, Yuliang and Luo, Zhang-Hong and Xiao, Wei and Yang, Fei and Jia, C. and Zhu, Tao and Zhang, Shushan}, title = {{Reduced retinal thickness and risk of Alzheimer’s disease: a bidirectional two-sample Mendelian randomization study}}, journal = {Ageing and Neurodegenerative Diseases}, year = {2025}, doi = {10.20517/and.2025.34}, url = {https://doi.org/10.20517/and.2025.34} } @article{payami1996-8644745, author = {Payami, H. and Zareparsi, S. and Montee, K. R. and Sexton, G. J. and Kaye, J. A. and Bird, T. D. and Yu, C. E. and Wijsman, E. M. and others}, title = {{Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women}}, journal = {American journal of human genetics}, year = {1996}, pmid = {8644745} } @article{bertrand1995-8774959, author = {Bertrand, P. and Poirier, J. and Oda, T. and Finch, C. E. and Pasinetti, G. M.}, title = {{Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease}}, journal = {Brain research. Molecular brain research}, year = {1995}, doi = {10.1016/0169-328x(95)00097-c}, pmid = {8774959}, url = {https://doi.org/10.1016/0169-328x(95)00097-c} } @article{tang1996-8644717, author = {Tang, M. X. and Maestre, G. and Tsai, W. Y. and Liu, X. H. and Feng, L. and Chung, W. Y. and Chun, M. and Schofield, P. and others}, title = {{Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City}}, journal = {American journal of human genetics}, year = {1996}, pmid = {8644717} } @article{egensperger1998-9669695, author = {Egensperger, R. and Kösel, S. and von Eitzen, U. and Graeber, M. B.}, title = {{Microglial activation in Alzheimer disease: Association with APOE genotype}}, journal = {Brain pathology (Zurich, Switzerland)}, year = {1998}, doi = {10.1111/j.1750-3639.1998.tb00166.x}, pmid = {9669695}, url = {https://doi.org/10.1111/j.1750-3639.1998.tb00166.x} } @article{floresdorantes2020-32982666, author = {Flores-Dorantes, M. T. and Díaz-López, Y. E. and Gutiérrez-Aguilar, R.}, title = {{Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases}}, journal = {Frontiers in neuroscience}, year = {2020}, doi = {10.3389/fnins.2020.00863}, pmid = {32982666}, url = {https://doi.org/10.3389/fnins.2020.00863} } @article{hyman2000-10815129, author = {Hyman, B. T. and Strickland, D. and Rebeck, G. W.}, title = {{Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease}}, journal = {Archives of neurology}, year = {2000}, doi = {10.1001/archneur.57.5.646}, pmid = {10815129}, url = {https://doi.org/10.1001/archneur.57.5.646} } @article{scott2000-10712207, author = {Scott, W. K. and Grubber, J. M. and Conneally, P. M. and Small, G. W. and Hulette, C. M. and Rosenberg, C. K. and Saunders, A. M. and Roses, A. D. and others}, title = {{Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity}}, journal = {American journal of human genetics}, year = {2000}, doi = {10.1086/302828}, pmid = {10712207}, url = {https://doi.org/10.1086/302828} } @article{moser2017-28612048, author = {Moser, V. A. and Pike, C. J.}, title = {{Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice}}, journal = {eNeuro}, year = {2017}, doi = {10.1523/eneuro.0077-17.2017}, pmid = {28612048}, url = {https://doi.org/10.1523/eneuro.0077-17.2017} } @article{penatauber2026-42548036, author = {Peña‐Tauber, Andrés and Arriaza, Ricardo Hernández and Reil, Dylan and Muntaner, Manon and Park, Junyoung and Grenier‐Boley, Benjamin and Hulsman, Marc and Amouyel, Philippe and others}, title = {{Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk}}, journal = {Annals of Neurology}, year = {2026}, doi = {10.1002/ana.78303}, pmid = {42548036}, url = {https://doi.org/10.1002/ana.78303} } @article{subramaniapillai2026-00ddbfb1, author = {Subramaniapillai, Sivaniya and Verdi, Serena and Keuss, Sarah E and Lu, Kirsty and James, Sarah‐Naomi and Coath, William and Cash, David M. and Barkhof, Frederik and others}, title = {{Mapping sex differences in brain and cognition in relation to APOE ε4 and amyloid burden: A longitudinal normative modelling study}}, journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions}, year = {2026}, doi = {10.1002/trc2.70223}, url = {https://doi.org/10.1002/trc2.70223} } @article{windham2024-37805344, author = {Windham, Ian A and Cohen, Sarah}, title = {{The cell biology of APOE in the brain}}, journal = {Trends in cell biology}, year = {2024}, doi = {10.1016/j.tcb.2023.09.004}, pmid = {37805344}, url = {https://doi.org/10.1016/j.tcb.2023.09.004} } @article{yassine2025-41224653, author = {Yassine, Hussein N and Hugo, Cristelle and O'Donovan, Bernadette and Stephens, Isaiah O and Johnson, Lance A and Cole, Gregory and Tcw, Julia and Johansson, Jan and others}, title = {{APOE-Targeted Therapeutics for Alzheimer's Disease}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2025}, doi = {10.1523/jneurosci.1388-25.2025}, pmid = {41224653}, url = {https://doi.org/10.1523/jneurosci.1388-25.2025} } @article{litvinchuk2024-37995685, author = {Litvinchuk, Alexandra and Suh, Jung H and Guo, Jing L and Lin, Karin and Davis, Sonnet S and Bien-Ly, Nga and Tycksen, Eric and Tabor, G Travis and others}, title = {{Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist}}, journal = {Neuron}, year = {2024}, doi = {10.1016/j.neuron.2023.10.023}, pmid = {37995685}, url = {https://doi.org/10.1016/j.neuron.2023.10.023} } @article{li2025-40112813, author = {Li, Zonghua and Martens, Yuka A and Ren, Yingxue and Jin, Yunjung and Sekiya, Hiroaki and Doss, Sydney V and Kouri, Naomi and Castanedes-Casey, Monica and others}, title = {{APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease}}, journal = {Neuron}, year = {2025}, doi = {10.1016/j.neuron.2025.02.017}, pmid = {40112813}, url = {https://doi.org/10.1016/j.neuron.2025.02.017} } @article{guo2025-39532095, author = {Guo, Jing L and Braun, Dylan and Fitzgerald, Gabriel A and Hsieh, Yun-Ting and Rougé, Lionel and Litvinchuk, Alexandra and Steffek, Micah and Propson, Nicholas E and others}, title = {{Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes}}, journal = {Cell}, year = {2025}, doi = {10.1016/j.cell.2024.10.027}, pmid = {39532095}, url = {https://doi.org/10.1016/j.cell.2024.10.027} } @article{preman2024-39528861, author = {Preman, Pranav and Moechars, Daan and Fertan, Emre and Wolfs, Leen and Serneels, Lutgarde and Shah, Disha and Lamote, Jochen and Poovathingal, Suresh and others}, title = {{APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia}}, journal = {EMBO molecular medicine}, year = {2024}, doi = {10.1038/s44321-024-00162-7}, pmid = {39528861}, url = {https://doi.org/10.1038/s44321-024-00162-7} } @article{ding2024-39394110, author = {Ding, Yunfeng and Palecek, Sean P and Shusta, Eric V}, title = {{iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta}}, journal = {Fluids and barriers of the CNS}, year = {2024}, doi = {10.1186/s12987-024-00580-2}, pmid = {39394110}, url = {https://doi.org/10.1186/s12987-024-00580-2} } @article{moon2024-39169951, author = {Moon, Hee-Jung and Luo, Yan and Chugh, Diksha and Zhao, Liqin}, title = {{Human apolipoprotein E glycosylation and sialylation: from structure to function}}, journal = {Frontiers in molecular neuroscience}, year = {2024}, doi = {10.3389/fnmol.2024.1399965}, pmid = {39169951}, url = {https://doi.org/10.3389/fnmol.2024.1399965} } @article{liampas2024-38339074, author = {Liampas, Ioannis and Kyriakoulopoulou, Panagiota and Siokas, Vasileios and Tsiamaki, Eirini and Stamati, Polyxeni and Kefalopoulou, Zinovia and Chroni, Elisabeth and Dardiotis, Efthimios}, title = {{Apolipoprotein E Gene in α-Synucleinopathies: A Narrative Review}}, journal = {International journal of molecular sciences}, year = {2024}, doi = {10.3390/ijms25031795}, pmid = {38339074}, url = {https://doi.org/10.3390/ijms25031795} } @article{budny2024-39056789, author = {Budny, Vanessa and Knöpfli, Yannic and Meier, Debora and Zürcher, Kathrin and Bodenmann, Chantal and Peter, Siri L and Müller, Terry and Tardy, Marie and others}, title = {{APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons}}, journal = {Cells}, year = {2024}, doi = {10.3390/cells13141207}, pmid = {39056789}, url = {https://doi.org/10.3390/cells13141207} } @article{shinohara2020-32211501, author = {Shinohara, Mitsuru and Tashiro, Yoshitaka and Suzuki, Kaoru and Fukumori, Akio and Bu, Guojun and Sato, Naoyuki}, title = {{Interaction between APOE genotype and diabetes in cognitive decline}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2020}, doi = {10.1002/dad2.12006}, pmid = {32211501}, url = {https://doi.org/10.1002/dad2.12006} } @article{reiss2024-39463215, author = {Reiss, Allison B and Housny, Mary and Gulkarov, Shelly and Hossain, Tahmina and Locke, Brandon and Srivastava, Ankita and Pinkhasov, Aaron and Gomolin, Irving H and others}, title = {{Role of Apolipoprotein E in Alzheimer's Disease Pathogenesis, Prognosis and Treatment}}, journal = {Discovery medicine}, year = {2024}, doi = {10.24976/discov.med.202436189.179}, pmid = {39463215}, url = {https://doi.org/10.24976/discov.med.202436189.179} } @article{zuniga2024-39666759, author = {Zuniga, Nathan R and Earls, Noah E and Denos, Ariel E A and Elison, Jared M and Jones, Benjamin S and Smith, Ethan G and Moran, Noah G and Broce, Katie L and others}, title = {{Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain}}, journal = {PLoS computational biology}, year = {2024}, doi = {10.1371/journal.pcbi.1012407}, pmid = {39666759}, url = {https://doi.org/10.1371/journal.pcbi.1012407} } @article{sen2017-28569173, author = {Sen, Abhik and Nelson, Thomas J and Alkon, Daniel L}, title = {{ApoE isoforms differentially regulates cleavage and secretion of BDNF}}, journal = {Molecular brain}, year = {2017}, doi = {10.1186/s13041-017-0301-3}, pmid = {28569173}, url = {https://doi.org/10.1186/s13041-017-0301-3} } @article{gause2017-29520379, author = {Gause, J W and Day, R J and Caraway, C A and Poon, W W and Rohn, T T}, title = {{Evaluation of Apolipoprotein E Fragmentation as a Biomarker for Alzheimer's Disease}}, journal = {Journal of neurology and neurological disorders}, year = {2017}, doi = {10.15744/2454-4981.3.204}, pmid = {29520379}, url = {https://doi.org/10.15744/2454-4981.3.204} } @article{fagla2024-38982272, author = {Fagla, Bani Medegan and York, Jason and Christensen, Amy and Rosa, Cielo Dela and Balu, Deebika and Pike, Christian J and Tai, Leon M and Buhimschi, Irina A}, title = {{Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease}}, journal = {Scientific reports}, year = {2024}, doi = {10.1038/s41598-024-66489-w}, pmid = {38982272}, url = {https://doi.org/10.1038/s41598-024-66489-w} } @article{xu2025-40962157, author = {Xu, Guilian and Angelle, Conner and Huilgol, Divya and Sacilotto, Patricia and McFarland, Karen N and Fromholt, Susan and Lopez, Amanda and Vo, Quan and others}, title = {{Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits}}, journal = {Neurobiology of disease}, year = {2025}, doi = {10.1016/j.nbd.2025.107105}, pmid = {40962157}, url = {https://doi.org/10.1016/j.nbd.2025.107105} } @article{odenkirk2024-38236019, author = {Odenkirk, Melanie T and Zheng, Xueyun and Kyle, Jennifer E and Stratton, Kelly G and Nicora, Carrie D and Bloodsworth, Kent J and Mclean, Catriona A and Masters, Colin L and others}, title = {{Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions}}, journal = {Journal of proteome research}, year = {2024}, doi = {10.1021/acs.jproteome.3c00604}, pmid = {38236019}, url = {https://doi.org/10.1021/acs.jproteome.3c00604} } @article{budny2025-40958776, author = {Budny, Vanessa and Bodenmann, Chantal and Zürcher, Kathrin J and Krüger, Maik and de Leeuw, Sherida M and Weber, Rebecca Z and Rust, Ruslan and Ravotto, Luca and others}, title = {{APOE genotype-dependent differences in human astrocytic energy metabolism}}, journal = {Frontiers in cellular neuroscience}, year = {2025}, doi = {10.3389/fncel.2025.1603657}, pmid = {40958776}, url = {https://doi.org/10.3389/fncel.2025.1603657} } @article{arriaza2025-41134549, author = {Arriaza, Ricardo Hernandez and Reil, Dylan and Fatuzzo, Nina and Fu, Mengying and Dai, Yuqin and Martinez, David Fernandez and Jiang, Hong and Holtzman, David M and others}, title = {{ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis}}, journal = {Biochemistry}, year = {2025}, doi = {10.1021/acs.biochem.5c00503}, pmid = {41134549}, url = {https://doi.org/10.1021/acs.biochem.5c00503} } @article{wang2024-39506961, author = {Wang, Ni and Parsons, Tammee M and Ren, Yingxue and Pan, Yining and Kurti, Aishe and Starling, Skylar C and Muolokwu, Chinenye and Singh, Jagdish and others}, title = {{Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in App NL-G-F mice}}, journal = {Heliyon}, year = {2024}, doi = {10.1016/j.heliyon.2024.e39607}, pmid = {39506961}, url = {https://doi.org/10.1016/j.heliyon.2024.e39607} } @article{blades2024-39135362, author = {Blades, Bryce and Hung, Ya Hui and Belaidi, Abdel A and Volitakis, Irene and Schultz, Aaron G and Cater, Michael A and Cheung, Nam Sang and Bush, Ashley I and others}, title = {{Impaired cellular copper regulation in the presence of ApoE4}}, journal = {Journal of neurochemistry}, year = {2024}, doi = {10.1111/jnc.16198}, pmid = {39135362}, url = {https://doi.org/10.1111/jnc.16198} } @article{he2024-37697966, author = {He, Mingyue and Lian, Tenghong and Guo, Peng and Zhang, Weijiao and Zhang, Yanan and Huang, Yue and Liu, Gaifen and Guan, Huiying and others}, title = {{The roles of apolipoprotein E ε4 on neuropathology and neuroinflammation in patients with Alzheimer's disease}}, journal = {CNS neuroscience \& therapeutics}, year = {2024}, doi = {10.1111/cns.14440}, pmid = {37697966}, url = {https://doi.org/10.1111/cns.14440} } @article{reas2024-38212861, author = {Reas, Emilie T and Triebswetter, Curtis and Banks, Sarah J and McEvoy, Linda K}, title = {{Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-023-01380-w}, pmid = {38212861}, url = {https://doi.org/10.1186/s13195-023-01380-w} } @article{tripathi2025-39722484, author = {Tripathi, Siddhant and Sharma, Yashika and Kumar, Dileep}, title = {{Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies}}, journal = {Current protein \& peptide science}, year = {2025}, doi = {10.2174/0113892037326839241014054430}, pmid = {39722484}, url = {https://doi.org/10.2174/0113892037326839241014054430} } @article{bassal2025-40164781, author = {Bassal, Rawan and Rivkin-Natan, Maria and Rabinovich, Alon and Michaelson, Daniel Moris and Frenkel, Dan and Pinkas-Kramarski, Ronit}, title = {{APOE4 impairs autophagy and Aβ clearance by microglial cells}}, journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]}, year = {2025}, doi = {10.1007/s00011-025-02016-5}, pmid = {40164781}, url = {https://doi.org/10.1007/s00011-025-02016-5} } @article{ghosh2024-38396791, author = {Ghosh, Shamasree and Tamilselvi, Shanmugam and Williams, Chloe and Jayaweera, Sanduni W and Iashchishyn, Igor A and Šulskis, Darius and Gilthorpe, Jonathan D and Olofsson, Anders and others}, title = {{ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9}}, journal = {International journal of molecular sciences}, year = {2024}, doi = {10.3390/ijms25042114}, pmid = {38396791}, url = {https://doi.org/10.3390/ijms25042114} } @article{anthony2025-41465183, author = {Anthony, Malcolm and Xie, Yixin and O'Neil, Jahn N and Teng, Shaolei}, title = {{Structural Analysis of Missense Mutations on the Stability of APOE3 and APOE4}}, journal = {Genes}, year = {2025}, doi = {10.3390/genes16121509}, pmid = {41465183}, url = {https://doi.org/10.3390/genes16121509} } @article{lozupone2024-37488848, author = {Lozupone, Madia and Panza, Francesco}, title = {{Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta}}, journal = {Neural regeneration research}, year = {2024}, doi = {10.4103/1673-5374.375316}, pmid = {37488848}, url = {https://doi.org/10.4103/1673-5374.375316} } @article{dibiase2025-40301465, author = {Di Biase, Erika and Connolly, Kyle J and Crumpton, Ingrid and Cooper, Oliver and Hallett, Penelope J and Isacson, Ole}, title = {{ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition}}, journal = {Scientific reports}, year = {2025}, doi = {10.1038/s41598-025-96531-4}, pmid = {40301465}, url = {https://doi.org/10.1038/s41598-025-96531-4} } @article{chen2025-40258814, author = {Chen, Junru and Chen, Haibing and Wei, Qinjun and Lu, Yajie and Wang, Tianming and Pang, Xiuhong and Xing, Guangqian and Chen, Zhibin and others}, title = {{APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae}}, journal = {Cell death discovery}, year = {2025}, doi = {10.1038/s41420-025-02454-4}, pmid = {40258814}, url = {https://doi.org/10.1038/s41420-025-02454-4} } @article{leclaire2024-39196521, author = {Leclaire, Kaitlynne N and Blujus, Jenna K and Korthauer, Laura E and Driscoll, Ira}, title = {{APOE4-related differences in cortical thickness are modulated by sex in middle age}}, journal = {Brain imaging and behavior}, year = {2024}, doi = {10.1007/s11682-024-00911-9}, pmid = {39196521}, url = {https://doi.org/10.1007/s11682-024-00911-9} } @article{zhang2024-39276310, author = {Zhang, Zhengrong and Lin, Weiwei and Gan, Qini and Lei, Maohua and Gong, Bin and Zhang, Chao and Henrique, Jessica Salles and Han, Jingyan and others}, title = {{The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP}}, journal = {Angiogenesis}, year = {2024}, doi = {10.1007/s10456-024-09946-4}, pmid = {39276310}, url = {https://doi.org/10.1007/s10456-024-09946-4} } @article{sjogren2001-11475012, author = {Sjögren, M and Hesse, C and Basun, H and Köl, G and Thostrup, H and Kilander, L and Marcusson, J and Edman, A and others}, title = {{Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype}}, journal = {Journal of neural transmission (Vienna, Austria : 1996)}, year = {2001}, doi = {10.1007/s007020170066}, pmid = {11475012}, url = {https://doi.org/10.1007/s007020170066} } @article{finch2007-17430245, author = {Finch, C. E. and Morgan, T. E.}, title = {{Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper}}, journal = {Current Alzheimer research}, year = {2007}, doi = {10.2174/156720507780362254}, pmid = {17430245}, url = {https://doi.org/10.2174/156720507780362254} } @article{carlson1997-9302276, author = {Carlson, G. A. and Borchelt, D. R. and Dake, A. and Turner, S. and Danielson, V. and Coffin, J. D. and Eckman, C. and Meiners, J. and others}, title = {{Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice}}, journal = {Human molecular genetics}, year = {1997}, doi = {10.1093/hmg/6.11.1951}, pmid = {9302276}, url = {https://doi.org/10.1093/hmg/6.11.1951} } @article{soininen1995-7783963, author = {Soininen, H. and Kosunen, O. and Helisalmi, S. and Mannermaa, A. and Paljärvi, L. and Talasniemi, S. and Ryynänen, M. and Riekkinen, P.}, title = {{A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele}}, journal = {Neuroscience letters}, year = {1995}, doi = {10.1016/0304-3940(95)11343-6}, pmid = {7783963}, url = {https://doi.org/10.1016/0304-3940(95)11343-6} } @article{montine1998-9596412, author = {Montine, K. S. and Reich, E. and Neely, M. D. and Sidell, K. R. and Olson, S. J. and Markesbery, W. R. and Montine, T. J.}, title = {{Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype}}, journal = {Journal of neuropathology and experimental neurology}, year = {1998}, doi = {10.1097/00005072-199805000-00005}, pmid = {9596412}, url = {https://doi.org/10.1097/00005072-199805000-00005} } @article{schwab2004-15191802, author = {Schwab, C. and Hosokawa, M. and McGeer, P. L.}, title = {{Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease}}, journal = {Experimental neurology}, year = {2004}, doi = {10.1016/j.expneurol.2004.03.016}, pmid = {15191802}, url = {https://doi.org/10.1016/j.expneurol.2004.03.016} } @article{collins2000-11121190, author = {Collins, J. S. and Perry, R. T. and Watson, B. and Harrell, L. E. and Acton, R. T. and Blacker, D. and Albert, M. S. and Tanzi, R. E. and others}, title = {{Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative}}, journal = {American journal of medical genetics}, year = {2000}, doi = {10.1002/1096-8628(20001204)96:6<823::aid-ajmg26>3.0.co;2-i}, pmid = {11121190}, url = {https://doi.org/10.1002/1096-8628(20001204)96:6<823::aid-ajmg26>3.0.co;2-i} } @article{hatters2005-16076841, author = {Hatters, D. M. and Budamagunta, M. S. and Voss, J. C. and Weisgraber, K. H.}, title = {{Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms}}, journal = {The Journal of biological chemistry}, year = {2005}, doi = {10.1074/jbc.m506044200}, pmid = {16076841}, url = {https://doi.org/10.1074/jbc.m506044200} } @article{khurshid2026-41857676, author = {Khurshid, Zainab and Tong, Tong and Olayinka, Oluwatosin A and Farrell, John Joseph and Zhu, Congcong and {Alzheimer's Disease Sequencing Project} and Martin, Eden R. and Bush, William S. and others}, title = {{Interactive effects of telomere length and genetic variants on Alzheimer disease risk across multiple ancestral populations}}, journal = {Alzheimer s Research \& Therapy}, year = {2026}, doi = {10.1186/s13195-026-02005-8}, pmid = {41857676}, url = {https://doi.org/10.1186/s13195-026-02005-8} } @article{norgren2025-41434470, author = {Norgren, Jakob and Carballo‐Casla, Adrián and Börjesson‐Hanson, Anne and Eriksdotter, Maria and Laukka, Erika J and Ptacek, Sara Garcia}, title = {{APOE‐Genotype Modifies the Association of Meat Consumption with Cognitive Decline: Longitudinal Analyses of The Swedish National Study on Aging and Care, SNAC‐K}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70860_107412}, pmid = {41434470}, url = {https://doi.org/10.1002/alz70860_107412} } @article{miners2006-17021406, author = {Miners, J. S. and Van Helmond, Z. and Chalmers, K. and Wilcock, G. and Love, S. and Kehoe, P. G.}, title = {{Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy}}, journal = {Journal of neuropathology and experimental neurology}, year = {2006}, doi = {10.1097/01.jnen.0000240463.87886.9a}, pmid = {17021406}, url = {https://doi.org/10.1097/01.jnen.0000240463.87886.9a} } @article{dekosky2007-17420316, author = {DeKosky, S. T. and Abrahamson, E. E. and Ciallella, JR. and Paljug, W. R. and Wisniewski, SR. and Clark, R. S. and Ikonomovic, M. D.}, title = {{Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans}}, journal = {Archives of neurology}, year = {2007}, doi = {10.1001/archneur.64.4.541}, pmid = {17420316}, url = {https://doi.org/10.1001/archneur.64.4.541} } @article{rasmussen2016-28340945, author = {Rasmussen, K. L.}, title = {{Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review}}, journal = {Atherosclerosis}, year = {2016}, doi = {10.1016/j.atherosclerosis.2016.10.037}, pmid = {28340945}, url = {https://doi.org/10.1016/j.atherosclerosis.2016.10.037} } @article{bana2014-24333591, author = {Bana, L. and Minniti, S. and Salvati, E. and Sesana, S. and Zambelli, V. and Cagnotto, A. and Orlando, A. and Cazzaniga, E. and others}, title = {{Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease}}, journal = {Nanomedicine : nanotechnology, biology, and medicine}, year = {2014}, doi = {10.1016/j.nano.2013.12.001}, pmid = {24333591}, url = {https://doi.org/10.1016/j.nano.2013.12.001} } @article{hooshmand2010-20956786, author = {Hooshmand, B. and Solomon, A. and Kåreholt, I. and Leiviskä, J. and Rusanen, M. and Ahtiluoto, S. and Winblad, B. and Laatikainen, T. and others}, title = {{Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181f88162}, pmid = {20956786}, url = {https://doi.org/10.1212/wnl.0b013e3181f88162} } @article{tai2014-25217640, author = {Tai, L. M. and Koster, K. P. and Luo, J. and Lee, S. H. and Wang, Y. T. and Collins, N. C. and Ben Aissa, M. and Thatcher, G. R. J. and others}, title = {{Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo}}, journal = {The Journal of biological chemistry}, year = {2014}, doi = {10.1074/jbc.m114.600833}, pmid = {25217640}, url = {https://doi.org/10.1074/jbc.m114.600833} } @article{cho2001-11305869, author = {Cho, H. S. and Hyman, B. T. and Greenberg, S. M. and Rebeck, G. W.}, title = {{Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation}}, journal = {Journal of neuropathology and experimental neurology}, year = {2001}, doi = {10.1093/jnen/60.4.342}, pmid = {11305869}, url = {https://doi.org/10.1093/jnen/60.4.342} } @article{alemany2015-26174813, author = {Alemany, S. and Ribasés, M. and Vilor-Tejedor, N. and Bustamante, M. and Sánchez-Mora, C. and Bosch, R. and Richarte, V. and Cormand, B. and others}, title = {{New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder}}, journal = {American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics}, year = {2015}, doi = {10.1002/ajmg.b.32341}, pmid = {26174813}, url = {https://doi.org/10.1002/ajmg.b.32341} } @article{jakalski2025-39998604, author = {Jąkalski, Marcin and Bruhn‐Olszewska, Bożena and Rychlicka-Buniowska, Edyta and Davies, Hanna and Sarkisyan, Daniil and Siedlar, Maciej and Baran, Jarosław and Węglarczyk, Kazimierz and others}, title = {{DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer´s disease}}, journal = {Cellular and Molecular Life Sciences}, year = {2025}, doi = {10.1007/s00018-025-05618-8}, pmid = {39998604}, url = {https://doi.org/10.1007/s00018-025-05618-8} } @article{vejdanijahromi2026-41781178, author = {Vejdani-Jahromi, Maryam and Calle, Esteban and Ganem, Odette and Rohatgi, Saurabh and Farzaneh, Hana and Griffin, Harry and Zhu, Shenghua and Seah, Jarrel C. Y. and others}, title = {{Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy}}, journal = {American Journal of Neuroradiology}, year = {2026}, doi = {10.3174/ajnr.a9056}, pmid = {41781178}, url = {https://doi.org/10.3174/ajnr.a9056} } @article{kumar2025-41040848, author = {Kumar, Atul and Binette, Alexa Pichet and Bali, Divya and Janelidze, Shorena and Stomrud, Erik and Palmqvist, Sebastian and Vogel, Jacob W. and Hansson, Oskar and others}, title = {{Cell-weighted polygenic risk scores are associated with β-amyloid and tau biomarkers in Alzheimer’s disease}}, journal = {Brain Communications}, year = {2025}, doi = {10.1093/braincomms/fcaf353}, pmid = {41040848}, url = {https://doi.org/10.1093/braincomms/fcaf353} } @article{kim2026-42234953, author = {Kim, Daeeun and McInerney, Katelyn and Dagli, Chaitali S. and Armstrong, Nicole D. and Cushman, Mary and Bennett, Aleena and Blue, Elizabeth E. and Sofer, Tamar and others}, title = {{Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population}}, journal = {Neurology}, year = {2026}, doi = {10.1212/wnl.0000000000218163}, pmid = {42234953}, url = {https://doi.org/10.1212/wnl.0000000000218163} } @article{cramer2012-22323736, author = {Cramer, P. E. and Cirrito, JR. and Wesson, D. W. and Lee, C. Y. and Karlo, J. C. and Zinn, A. E. and Casali, B. T. and Restivo, J. L. and others}, title = {{ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models}}, journal = {Science (New York, N.Y.)}, year = {2012}, doi = {10.1126/science.1217697}, pmid = {22323736}, url = {https://doi.org/10.1126/science.1217697} } @article{nathan1994-8171342, author = {Nathan, B. P. and Bellosta, S. and Sanan, D. A. and Weisgraber, K. H. and Mahley, R. W. and Pitas, R. E.}, title = {{Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro}}, journal = {Science (New York, N.Y.)}, year = {1994}, doi = {10.1126/science.8171342}, pmid = {8171342}, url = {https://doi.org/10.1126/science.8171342} } @article{arranz2019-30795987, author = {Arranz, A. M. and De Strooper, B.}, title = {{The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications}}, journal = {The Lancet. Neurology}, year = {2019}, doi = {10.1016/s1474-4422(18)30490-3}, pmid = {30795987}, url = {https://doi.org/10.1016/s1474-4422(18)30490-3} } @article{sun2023-37227619, author = {Sun, Yu-Ying and Wang, Zhun and Huang, Han-Chang}, title = {{Roles of ApoE4 on the Pathogenesis in Alzheimer's Disease and the Potential Therapeutic Approaches}}, journal = {Cellular and molecular neurobiology}, year = {2023}, doi = {10.1007/s10571-023-01365-1}, pmid = {37227619}, url = {https://doi.org/10.1007/s10571-023-01365-1} } @article{fernandezcalle2022-36153580, author = {Fernández-Calle, Rosalía and Konings, Sabine C and Frontiñán-Rubio, Javier and García-Revilla, Juan and Camprubí-Ferrer, Lluís and Svensson, Martina and Martinson, Isak and Boza-Serrano, Antonio and others}, title = {{APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases}}, journal = {Molecular neurodegeneration}, year = {2022}, doi = {10.1186/s13024-022-00566-4}, pmid = {36153580}, url = {https://doi.org/10.1186/s13024-022-00566-4} } @article{eskandarisedighi2023-38115077, author = {Eskandari-Sedighi, Ghazaleh and Blurton-Jones, Mathew}, title = {{Microglial APOE4: more is less and less is more}}, journal = {Molecular neurodegeneration}, year = {2023}, doi = {10.1186/s13024-023-00693-6}, pmid = {38115077}, url = {https://doi.org/10.1186/s13024-023-00693-6} } @article{lanfranco2021-33556209, author = {Lanfranco, Maria Fe and Sepulveda, Jordy and Kopetsky, Gregory and Rebeck, G William}, title = {{Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation}}, journal = {Glia}, year = {2021}, doi = {10.1002/glia.23974}, pmid = {33556209}, url = {https://doi.org/10.1002/glia.23974} } @article{mah2023-37014788, author = {Mah, Dylan and Zhu, Yanan and Su, Guowei and Zhao, Jing and Canning, Ashely and Gibson, James and Song, Xuehong and Stancanelli, Eduardo and others}, title = {{Apolipoprotein E Recognizes Alzheimer's Disease Associated 3-O Sulfation of Heparan Sulfate}}, journal = {Angewandte Chemie (International ed. in English)}, year = {2023}, doi = {10.1002/anie.202212636}, pmid = {37014788}, url = {https://doi.org/10.1002/anie.202212636} } @article{adaku2023-37335131, author = {Adaku, Nneoma and Ostendorf, Benjamin N and Mei, Wenbin and Tavazoie, Sohail F}, title = {{Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis}}, journal = {Cancer research}, year = {2023}, doi = {10.1158/0008-5472.can-23-1252}, pmid = {37335131}, url = {https://doi.org/10.1158/0008-5472.can-23-1252} } @article{chai2021-34044125, author = {Chai, Amanda B and Lam, Hin Hei Julian and Kockx, Maaike and Gelissen, Ingrid C}, title = {{Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β}}, journal = {Biochimica et biophysica acta. Molecular and cell biology of lipids}, year = {2021}, doi = {10.1016/j.bbalip.2021.158980}, pmid = {34044125}, url = {https://doi.org/10.1016/j.bbalip.2021.158980} } @article{alagarsamy2022-36077289, author = {Alagarsamy, Jeyashree and Jaeschke, Anja and Hui, David Y}, title = {{Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases}}, journal = {International journal of molecular sciences}, year = {2022}, doi = {10.3390/ijms23179892}, pmid = {36077289}, url = {https://doi.org/10.3390/ijms23179892} } @article{shinohara2023-37414536, author = {Shinohara, Mitsuru and Gheni, Ghupurjan and Hitomi, Junichi and Bu, Guojun and Sato, Naoyuki}, title = {{APOE genotypes modify the obesity paradox in dementia}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2023}, doi = {10.1136/jnnp-2022-331034}, pmid = {37414536}, url = {https://doi.org/10.1136/jnnp-2022-331034} } @article{kurano2022-34958030, author = {Kurano, Makoto and Tsukamoto, Kazuhisa and Sakai, Eri and Hara, Masumi and Yatomi, Yutaka}, title = {{Isoform-Dependent Effects of Apolipoprotein E on Sphingolipid Metabolism in Neural Cells}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2022}, doi = {10.3233/jad-215205}, pmid = {34958030}, url = {https://doi.org/10.3233/jad-215205} } @article{moon2022-35041991, author = {Moon, Hee-Jung and Haroutunian, Vahram and Zhao, Liqin}, title = {{Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Aβ interaction and Aβ fibrillation}}, journal = {Neurobiology of disease}, year = {2022}, doi = {10.1016/j.nbd.2022.105631}, pmid = {35041991}, url = {https://doi.org/10.1016/j.nbd.2022.105631} } @article{mai2022-35582645, author = {Mai, Zhenhua and Wei, Wenyan and Yu, Haibin and Chen, Yongze and Wang, Yongxiang and Ding, Yuanlin}, title = {{Molecular recognition of the interaction between ApoE and the TREM2 protein}}, journal = {Translational neuroscience}, year = {2022}, doi = {10.1515/tnsci-2022-0218}, pmid = {35582645}, url = {https://doi.org/10.1515/tnsci-2022-0218} } @article{stuchellbrereton2023-36749730, author = {Stuchell-Brereton, Melissa D and Zimmerman, Maxwell I and Miller, Justin J and Mallimadugula, Upasana L and Incicco, J Jeremías and Roy, Debjit and Smith, Louis G and Cubuk, Jasmine and others}, title = {{Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2023}, doi = {10.1073/pnas.2215371120}, pmid = {36749730}, url = {https://doi.org/10.1073/pnas.2215371120} } @article{hu2021-34210002, author = {Hu, Monica L and Quinn, Joel and Xue, Kanmin}, title = {{Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration}}, journal = {Life (Basel, Switzerland)}, year = {2021}, doi = {10.3390/life11070635}, pmid = {34210002}, url = {https://doi.org/10.3390/life11070635} } @article{heinsinger2016-27516118, author = {Heinsinger, Nicolette Mary and Gachechiladze, Mariam Alexandra and Rebeck, G William}, title = {{Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid}}, journal = {Journal of neuropathology and experimental neurology}, year = {2016}, doi = {10.1093/jnen/nlw067}, pmid = {27516118}, url = {https://doi.org/10.1093/jnen/nlw067} } @article{hou2023-37040764, author = {Hou, Xianglong and Zhang, Xuexin and Zou, Huan and Guan, Mingfeng and Fu, Chaoying and Wang, Wenyuan and Zhang, Zai-Rong and Geng, Yang and others}, title = {{Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4}}, journal = {Neuron}, year = {2023}, doi = {10.1016/j.neuron.2023.03.024}, pmid = {37040764}, url = {https://doi.org/10.1016/j.neuron.2023.03.024} } @article{vecchio2022-35321401, author = {Vecchio, Filomena Lo and Bisceglia, Paola and Imbimbo, Bruno Pietro and Lozupone, Madia and Latino, Raffaela Rita and Resta, Emanuela and Leone, Maurizio and Solfrizzi, Vincenzo and others}, title = {{Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer's disease?}}, journal = {Therapeutic advances in chronic disease}, year = {2022}, doi = {10.1177/20406223221081605}, pmid = {35321401}, url = {https://doi.org/10.1177/20406223221081605} } @article{zhang2021-34530340, author = {Zhang, Jing and Lin, Lanyan and Dai, Xiaoman and Xiao, Nai'an and Ye, Qinyong and Chen, Xiaochun}, title = {{ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment}}, journal = {Journal of psychiatric research}, year = {2021}, doi = {10.1016/j.jpsychires.2021.09.029}, pmid = {34530340}, url = {https://doi.org/10.1016/j.jpsychires.2021.09.029} } @article{ramakrishna2021-34475200, author = {Ramakrishna, Sarayu and Jhaveri, Vishwaja and Konings, Sabine C and Nawalpuri, Bharti and Chakraborty, Sumita and Holst, Bjørn and Schmid, Benjamin and Gouras, Gunnar K and others}, title = {{APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2021}, doi = {10.1523/jneurosci.0435-21.2021}, pmid = {34475200}, url = {https://doi.org/10.1523/jneurosci.0435-21.2021} } @article{nishimura2014-24454848, author = {Nishimura, Motoi and Satoh, Mamoru and Nishimura, Satomi and Kakinuma, Shoko and Sato, Kenichi and Sawai, Setsu and Tsuchida, Sachio and Kazama, Takeshi and others}, title = {{Human apolipoprotein e resequencing by proteomic analysis and its application to serotyping}}, journal = {PloS one}, year = {2014}, doi = {10.1371/journal.pone.0085356}, pmid = {24454848}, url = {https://doi.org/10.1371/journal.pone.0085356} } @article{sung2023-37163733, author = {Sung, Jin Hee and Ou, Yang and Barger, Steven W}, title = {{Amyloid β-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype}}, journal = {eNeuro}, year = {2023}, doi = {10.1523/eneuro.0376-22.2023}, pmid = {37163733}, url = {https://doi.org/10.1523/eneuro.0376-22.2023} } @article{wooten2021-33138883, author = {Wooten, Thomas and Sullivan, Danielle R and Logue, Mark W and Fonda, Jennifer R and Fortier, Catherine B and DeGutis, Joseph and McGlinchey, Regina and Milberg, William and others}, title = {{Apolipoprotein E (APOE) ε4 Status Moderates the Relationship Between Close-Range Blast Exposure and Cognitive Functioning}}, journal = {Journal of the International Neuropsychological Society : JINS}, year = {2021}, doi = {10.1017/s1355617720001034}, pmid = {33138883}, url = {https://doi.org/10.1017/s1355617720001034} } @article{lv2023-37594184, author = {Lv, Shuixin and Zhang, Yusi and Lin, Yingbin and Fang, Wenting and Wang, Yu and Li, Zihang and Lin, Anlan and Dai, Xiaoman and others}, title = {{ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl-CoA level}}, journal = {Aging cell}, year = {2023}, doi = {10.1111/acel.13932}, pmid = {37594184}, url = {https://doi.org/10.1111/acel.13932} } @article{chernyaeva2023-37155564, author = {Chernyaeva, Larisa and Ratti, Giorgio and Teirilä, Laura and Fudo, Satoshi and Rankka, Uni and Pelkonen, Anssi and Korhonen, Paula and Leskinen, Katarzyna and others}, title = {{Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation}}, journal = {EMBO reports}, year = {2023}, doi = {10.15252/embr.202256467}, pmid = {37155564}, url = {https://doi.org/10.15252/embr.202256467} } @article{levy2021-34672451, author = {Levy, Yishai and Levy, David}, title = {{A Friend and a Foe: 50 Years of the Apolipoprotein E Research Trail}}, journal = {The Israel Medical Association journal : IMAJ}, year = {2021}, pmid = {34672451} } @article{michaelson2014-25217293, author = {Michaelson, Daniel M}, title = {{APOE ε4: the most prevalent yet understudied risk factor for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2014}, doi = {10.1016/j.jalz.2014.06.015}, pmid = {25217293}, url = {https://doi.org/10.1016/j.jalz.2014.06.015} } @article{dumanis2009-19955384, author = {Dumanis, Sonya B and Tesoriero, Joseph A and Babus, Lenard W and Nguyen, Madeline T and Trotter, Justin H and Ladu, Mary Jo and Weeber, Edwin J and Turner, R Scott and others}, title = {{ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2009}, doi = {10.1523/jneurosci.4026-09.2009}, pmid = {19955384}, url = {https://doi.org/10.1523/jneurosci.4026-09.2009} } @article{lee2021-34450034, author = {Lee, Se-In and Jeong, Woojin and Lim, Heejin and Cho, Sukhee and Lee, Hyein and Jang, Yonghee and Cho, Joonho and Bae, Simsung and others}, title = {{APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation}}, journal = {Stem cell reports}, year = {2021}, doi = {10.1016/j.stemcr.2021.07.017}, pmid = {34450034}, url = {https://doi.org/10.1016/j.stemcr.2021.07.017} } @article{alata2015-25335802, author = {Alata, Wael and Ye, Yue and St-Amour, Isabelle and Vandal, Milène and Calon, Frédéric}, title = {{Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice}}, journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year = {2015}, doi = {10.1038/jcbfm.2014.172}, pmid = {25335802}, url = {https://doi.org/10.1038/jcbfm.2014.172} } @article{risacher2015-25960448, author = {Risacher, Shannon L and Kim, Sungeun and Nho, Kwangsik and Foroud, Tatiana and Shen, Li and Petersen, Ronald C and Jack, Clifford R and Beckett, Laurel A and others}, title = {{APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2015.03.003}, pmid = {25960448}, url = {https://doi.org/10.1016/j.jalz.2015.03.003} } @article{liemisa2023-38058491, author = {Liemisa, Braison and Newbury, Samantha F and Novy, Mariah J and Pasato, Jonathan A and Morales-Corraliza, Jose and Peng, Katherine Y and Mathews, Paul M}, title = {{Brain apolipoprotein E levels in mice challenged by a Western diet increase in an allele-dependent manner}}, journal = {Aging brain}, year = {2023}, doi = {10.1016/j.nbas.2023.100102}, pmid = {38058491}, url = {https://doi.org/10.1016/j.nbas.2023.100102} } @article{zhang2023-36766752, author = {Zhang, Xin and Wu, Long and Swerdlow, Russell H and Zhao, Liqin}, title = {{Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer's Disease}}, journal = {Cells}, year = {2023}, doi = {10.3390/cells12030410}, pmid = {36766752}, url = {https://doi.org/10.3390/cells12030410} } @article{miao2023-36516696, author = {Miao, Ganggang and Zhuo, Danping and Han, Xue and Yao, Wentao and Liu, Chuan and Liu, Hanyuan and Cao, Hongyong and Sun, Yangbai and others}, title = {{From degenerative disease to malignant tumors: Insight to the function of ApoE}}, journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie}, year = {2023}, doi = {10.1016/j.biopha.2022.114127}, pmid = {36516696}, url = {https://doi.org/10.1016/j.biopha.2022.114127} } @article{madrid2021-33846280, author = {Madrid, Laura and Moreno-Grau, Sonia and Ahmad, Shahzad and González-Pérez, Antonio and de Rojas, Itziar and Xia, Rui and Adami, Pamela V Martino and García-González, Pablo and others}, title = {{Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis}}, journal = {Aging}, year = {2021}, doi = {10.18632/aging.202950}, pmid = {33846280}, url = {https://doi.org/10.18632/aging.202950} } @article{steele2022-35510513, author = {Steele, Oliver George and Stuart, Alexander Cameron and Minkley, Lucy and Shaw, Kira and Bonnar, Orla and Anderle, Silvia and Penn, Andrew Charles and Rusted, Jennifer and others}, title = {{A multi-hit hypothesis for an APOE4-dependent pathophysiological state}}, journal = {The European journal of neuroscience}, year = {2022}, doi = {10.1111/ejn.15685}, pmid = {35510513}, url = {https://doi.org/10.1111/ejn.15685} } @article{saunders2000-11005255, author = {Saunders, A. M.}, title = {{Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses}}, journal = {Journal of neuropathology and experimental neurology}, year = {2000}, doi = {10.1093/jnen/59.9.751}, pmid = {11005255}, url = {https://doi.org/10.1093/jnen/59.9.751} } @article{kuo2001-11778650, author = {Kuo, Y. M. and Beach, T. G. and Sue, L. I. and Scott, S. and Layne, K. J. and Kokjohn, T. A. and Kalback, W. M. and Luehrs, D. C. and others}, title = {{The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease}}, journal = {Molecular medicine (Cambridge, Mass.)}, year = {2001}, doi = {10.1007/bf03401867}, pmid = {11778650}, url = {https://doi.org/10.1007/bf03401867} } @article{nasciben2025-40704449, author = {Nasciben, Luciana Bertholim and Nuytemans, Karen and Van Booven, Derek J. and Rajabli, Farid and Moura, Sofia and Ramírez, Aura María and Parker, Griffin S. and Dykxhoorn, Derek M. and others}, title = {{Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOEε4 carriers}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70500}, pmid = {40704449}, url = {https://doi.org/10.1002/alz.70500} } @article{dietschy2001-11264981, author = {Dietschy, J. M. and Turley, S. D.}, title = {{Cholesterol metabolism in the brain}}, journal = {Current opinion in lipidology}, year = {2001}, doi = {10.1097/00041433-200104000-00003}, pmid = {11264981}, url = {https://doi.org/10.1097/00041433-200104000-00003} } @article{miyata1996-8782820, author = {Miyata, M. and Smith, J. D.}, title = {{Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides}}, journal = {Nature genetics}, year = {1996}, doi = {10.1038/ng0996-55}, pmid = {8782820}, url = {https://doi.org/10.1038/ng0996-55} } @article{puglielli2003-12658281, author = {Puglielli, L. and Tanzi, R. E. and Kovacs, D. M.}, title = {{Alzheimer's disease: the cholesterol connection}}, journal = {Nature neuroscience}, year = {2003}, doi = {10.1038/nn0403-345}, pmid = {12658281}, url = {https://doi.org/10.1038/nn0403-345} } @article{notkola1998-9549720, author = {Notkola, I. L. and Sulkava, R. and Pekkanen, J. and Erkinjuntti, T. and Ehnholm, C. and Kivinen, P. and Tuomilehto, J. and Nissinen, A.}, title = {{Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease}}, journal = {Neuroepidemiology}, year = {1998}, doi = {10.1159/000026149}, pmid = {9549720}, url = {https://doi.org/10.1159/000026149} } @article{kim2013-23467355, author = {Kim, W. S. and Li, H. and Ruberu, K. and Chan, S. and Elliott, D. A. and Low, J. K. and Cheng, D. and Karl, T. and others}, title = {{Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2013}, doi = {10.1523/jneurosci.4165-12.2013}, pmid = {23467355}, url = {https://doi.org/10.1523/jneurosci.4165-12.2013} } @article{tcw2022-35750033, author = {Tcw, J. and Qian, L. and Pipalia, N. H. and Chao, M. J. and Liang, S. A. and Shi, Y. and Jain, B. R. and Bertelsen, S. E. and others}, title = {{Cholesterol and matrisome pathways dysregulated in astrocytes and microglia}}, journal = {Cell}, year = {2022}, doi = {10.1016/j.cell.2022.05.017}, pmid = {35750033}, url = {https://doi.org/10.1016/j.cell.2022.05.017} } @article{wang2021-33831349, author = {Wang, C. and Xiong, M. and Gratuze, M. and Bao, X. and Shi, Y. and Andhey, P. S. and Manis, M. and Schroeder, C. and others}, title = {{Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia}}, journal = {Neuron}, year = {2021}, doi = {10.1016/j.neuron.2021.03.024}, pmid = {33831349}, url = {https://doi.org/10.1016/j.neuron.2021.03.024} } @article{ladu1994-8089103, author = {LaDu, Mary Jo and Falduto, Michael T. and Manelli, Arlene M. and Reardon, C.A. and Getz, Godfrey S. and Frail, D E}, title = {{Isoform-specific binding of apolipoprotein E to beta-amyloid}}, journal = {Journal of Biological Chemistry}, year = {1994}, doi = {10.1016/s0021-9258(17)31529-6}, pmid = {8089103}, url = {https://doi.org/10.1016/s0021-9258(17)31529-6} } @article{schindler2004-15269217, author = {Schindler, Suzanne E. and Jiang, Hong and Parsadanian, Maia and Legleiter, Justin A. and Han, Xianlin and Fryer, John Denis and Kowalewski, Tomasz and Holtzman, David M.}, title = {{ABCA1 Is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE}}, journal = {Journal of Biological Chemistry}, year = {2004}, doi = {10.1074/jbc.m407963200}, pmid = {15269217}, url = {https://doi.org/10.1074/jbc.m407963200} } @article{nakai1996-8809843, author = {Nakai, M. and Kawamata, T. and Taniguchi, T. and Maeda, K. and Tanaka, C.}, title = {{Expression of apolipoprotein E mRNA in rat microglia}}, journal = {Neuroscience letters}, year = {1996}, doi = {10.1016/0304-3940(96)12716-6}, pmid = {8809843}, url = {https://doi.org/10.1016/0304-3940(96)12716-6} } @article{bickeboller1997-9012418, author = {Bickeböller, H. and Campion, D. and Brice, A. and Amouyel, P. and Hannequin, D. and Didierjean, O. and Penet, C. and Martin, C. and others}, title = {{Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex}}, journal = {American journal of human genetics}, year = {1997}, pmid = {9012418} } @article{utter2008-18716559, author = {Utter, S. and Tamboli, I. Y. and Walter, J. and Upadhaya, A. R. and Birkenmeier, G. and Pietrzik, C. U. and Ghebremedhin, E. and Thal, D. R.}, title = {{Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes}}, journal = {Journal of neuropathology and experimental neurology}, year = {2008}, doi = {10.1097/nen.0b013e3181836a71}, pmid = {18716559}, url = {https://doi.org/10.1097/nen.0b013e3181836a71} } @article{donahue2008-18379441, author = {Donahue, J. E. and Johanson, C. E.}, title = {{Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease}}, journal = {Journal of neuropathology and experimental neurology}, year = {2008}, doi = {10.1097/nen.0b013e31816a0dc8}, pmid = {18379441}, url = {https://doi.org/10.1097/nen.0b013e31816a0dc8} } @article{wang2025-40905109, author = {Wang, Yuying and Gao, Yang and Wang, Yarong and Zhang, Fuqiang and Sun, Fei and Wang, Xin and Xie, Jiazhao and Xu, Zhipeng and others}, title = {{ApoE4 Upregulates GSK ‐3β to Aggravate Alzheimer‐Like Pathologies and Cognitive Impairment in Type 2 Diabetic Mice}}, journal = {CNS Neuroscience \& Therapeutics}, year = {2025}, doi = {10.1111/cns.70575}, pmid = {40905109}, url = {https://doi.org/10.1111/cns.70575} } @article{ye2025-41074912, author = {Ye, Rong and Goodheart, Anna E. and Locascio, Joseph J. and Peterec, Erin and Stancu, Patrick and Wang, Yanhong and Gomperts, Stephen N.}, title = {{APOE ε4 linked effects on clinical features and neuropathology in dementia with Lewy bodies}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70795}, pmid = {41074912}, url = {https://doi.org/10.1002/alz.70795} } @article{liu2025-41044651, author = {Liu, Hongwei and Yin, Zhaoxu and Chen, Xuan and Wang, Zhijun}, title = {{Exploring causal relationships between epigenetic age acceleration and Alzheimer’s disease: a bidirectional Mendelian randomization study}}, journal = {Clinical Epigenetics}, year = {2025}, doi = {10.1186/s13148-025-01976-z}, pmid = {41044651}, url = {https://doi.org/10.1186/s13148-025-01976-z} } @article{gao2026-42152315, author = {Gao, Xueying and Wang, Lingling}, title = {{Associations of gut bacterial classes Clostridia and Deltaproteobacteria with type 2 diabetes and Alzheimer’s disease: A two-sample Mendelian randomization study}}, journal = {Medicine}, year = {2026}, doi = {10.1097/md.0000000000048685}, pmid = {42152315}, url = {https://doi.org/10.1097/md.0000000000048685} } @article{li2020-33148290, author = {Li, Zonghua and Shue, Francis and Zhao, Na and Shinohara, Mitsuru and Bu, Guojun}, title = {{APOE2: protective mechanism and therapeutic implications for Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2020}, doi = {10.1186/s13024-020-00413-4}, pmid = {33148290}, url = {https://doi.org/10.1186/s13024-020-00413-4} } @article{james2017-28299413, author = {James, Lisa M and Engdahl, Brian E and Georgopoulos, Apostolos P}, title = {{Apolipoprotein E: the resilience gene}}, journal = {Experimental brain research}, year = {2017}, doi = {10.1007/s00221-017-4941-4}, pmid = {28299413}, url = {https://doi.org/10.1007/s00221-017-4941-4} } @article{yassine2020-32587511, author = {Yassine, Hussein N and Finch, Caleb E}, title = {{APOE Alleles and Diet in Brain Aging and Alzheimer's Disease}}, journal = {Frontiers in aging neuroscience}, year = {2020}, doi = {10.3389/fnagi.2020.00150}, pmid = {32587511}, url = {https://doi.org/10.3389/fnagi.2020.00150} } @article{gharibyan2020-31947546, author = {Gharibyan, Anna L and Islam, Tohidul and Pettersson, Nina and Golchin, Solmaz A and Lundgren, Johanna and Johansson, Gabriella and Genot, Mélany and Schultz, Nina and others}, title = {{Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity}}, journal = {Biomolecules}, year = {2020}, doi = {10.3390/biom10010134}, pmid = {31947546}, url = {https://doi.org/10.3390/biom10010134} } @article{ringland2020-32758917, author = {Ringland, Charis and Schweig, Jonas Elias and Paris, Daniel and Shackleton, Ben and Lynch, Cillian E and Eisenbaum, Maxwell and Mullan, Michael and Crawford, Fiona and others}, title = {{Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease}}, journal = {Neurobiology of aging}, year = {2020}, doi = {10.1016/j.neurobiolaging.2020.06.018}, pmid = {32758917}, url = {https://doi.org/10.1016/j.neurobiolaging.2020.06.018} } @article{suidan2019-31052389, author = {Suidan, Georgette L and Ramaswamy, Gayathri}, title = {{Targeting Apolipoprotein E for Alzheimer's Disease: An Industry Perspective}}, journal = {International journal of molecular sciences}, year = {2019}, doi = {10.3390/ijms20092161}, pmid = {31052389}, url = {https://doi.org/10.3390/ijms20092161} } @article{rosenberg2018-29409358, author = {Rosenberg, Jonathan B and Kaplitt, Michael G and De, Bishnu P and Chen, Alvin and Flagiello, Thomas and Salami, Christiana and Pey, Eduard and Zhao, Lingzhi and others}, title = {{AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease}}, journal = {Human gene therapy. Clinical development}, year = {2018}, doi = {10.1089/humc.2017.231}, pmid = {29409358}, url = {https://doi.org/10.1089/humc.2017.231} } @article{yin2018-30232753, author = {Yin, Yuemiao and Wang, Zhao}, title = {{ApoE and Neurodegenerative Diseases in Aging}}, journal = {Advances in experimental medicine and biology}, year = {2018}, doi = {10.1007/978-981-13-1117-8_5}, pmid = {30232753}, url = {https://doi.org/10.1007/978-981-13-1117-8_5} } @article{hubin2019-31058310, author = {Hubin, Ellen and Verghese, Philip B and van Nuland, Nico and Broersen, Kerensa}, title = {{Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation}}, journal = {FEBS letters}, year = {2019}, doi = {10.1002/1873-3468.13428}, pmid = {31058310}, url = {https://doi.org/10.1002/1873-3468.13428} } @article{koreniton2020-32075060, author = {Koren-Iton, Amit and Salomon-Zimri, Shiran and Smolar, Alex and Shavit-Stein, Efrat and Dori, Amir and Chapman, Joab and Michaelson, Daniel M}, title = {{Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology}}, journal = {International journal of molecular sciences}, year = {2020}, doi = {10.3390/ijms21041289}, pmid = {32075060}, url = {https://doi.org/10.3390/ijms21041289} } @article{berkowitz2018-30298183, author = {Berkowitz, C L and Mosconi, L and Rahman, A and Scheyer, O and Hristov, H and Isaacson, R S}, title = {{Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2018}, doi = {10.14283/jpad.2018.35}, pmid = {30298183}, url = {https://doi.org/10.14283/jpad.2018.35} } @article{veiga2020-32034174, author = {Veiga, Sergio and Rodríguez-Martín, Andrés and Garcia-Ribas, Guillermo and Arribas, Ignacio and Menacho-Román, Miriam and Calero, Miguel}, title = {{Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers}}, journal = {Scientific reports}, year = {2020}, doi = {10.1038/s41598-020-58841-7}, pmid = {32034174}, url = {https://doi.org/10.1038/s41598-020-58841-7} } @article{lanfranco2020-32882843, author = {Lanfranco, Maria Fe and Ng, Christi Anne and Rebeck, G William}, title = {{ApoE Lipidation as a Therapeutic Target in Alzheimer's Disease}}, journal = {International journal of molecular sciences}, year = {2020}, doi = {10.3390/ijms21176336}, pmid = {32882843}, url = {https://doi.org/10.3390/ijms21176336} } @article{kloske2020-32425941, author = {Kloske, Courtney M and Wilcock, Donna M}, title = {{The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease}}, journal = {Frontiers in immunology}, year = {2020}, doi = {10.3389/fimmu.2020.00754}, pmid = {32425941}, url = {https://doi.org/10.3389/fimmu.2020.00754} } @article{huang2019-31331998, author = {Huang, Yu-Wen Alvin and Zhou, Bo and Nabet, Amber M and Wernig, Marius and Südhof, Thomas C}, title = {{Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2019}, doi = {10.1523/jneurosci.2994-18.2019}, pmid = {31331998}, url = {https://doi.org/10.1523/jneurosci.2994-18.2019} } @article{saelee2020-32580938, author = {Sae-Lee, Wisath and Scott, Luisa L and Brose, Lotti and Encarnacion, Aliyah J and Shi, Ted and Kore, Pragati and Oyibo, Lashaun O and Ye, Congxi and others}, title = {{APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans}}, journal = {G3 (Bethesda, Md.)}, year = {2020}, doi = {10.1534/g3.120.401486}, pmid = {32580938}, url = {https://doi.org/10.1534/g3.120.401486} } @article{tensaouti2020-32119690, author = {Tensaouti, Yacine and Yu, Tzong-Shiue and Kernie, Steven G}, title = {{Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury}}, journal = {PloS one}, year = {2020}, doi = {10.1371/journal.pone.0229240}, pmid = {32119690}, url = {https://doi.org/10.1371/journal.pone.0229240} } @article{shackleton2017-28164773, author = {Shackleton, Ben and Crawford, Fiona and Bachmeier, Corbin}, title = {{Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease}}, journal = {Current Alzheimer research}, year = {2017}, doi = {10.2174/1567205014666170203093219}, pmid = {28164773}, url = {https://doi.org/10.2174/1567205014666170203093219} } @article{east2018-29678753, author = {East, Brett S and Fleming, Gloria and Peng, Kathy and Olofsson, Jonas K and Levy, Efrat and Mathews, Paul M and Wilson, Donald A}, title = {{Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice}}, journal = {Neuroscience}, year = {2018}, doi = {10.1016/j.neuroscience.2018.04.009}, pmid = {29678753}, url = {https://doi.org/10.1016/j.neuroscience.2018.04.009} } @article{munoz2019-30225748, author = {Muñoz, Sonia Sanz and Garner, Brett and Ooi, Lezanne}, title = {{Understanding the Role of ApoE Fragments in Alzheimer's Disease}}, journal = {Neurochemical research}, year = {2019}, doi = {10.1007/s11064-018-2629-1}, pmid = {30225748}, url = {https://doi.org/10.1007/s11064-018-2629-1} } @article{eich2019-31473197, author = {Eich, Teal S and Tsapanou, Angeliki and Stern, Yaakov}, title = {{When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age}}, journal = {Neuropsychologia}, year = {2019}, doi = {10.1016/j.neuropsychologia.2019.107180}, pmid = {31473197}, url = {https://doi.org/10.1016/j.neuropsychologia.2019.107180} } @article{mamun2020-32509144, author = {Mamun, Abdullah Al and Uddin, Md Sahab and Bashar, Md Fahim Bin and Zaman, Sonia and Begum, Yesmin and Bulbul, Israt Jahan and Islam, Md Siddiqul and Sarwar, Md Shahid and others}, title = {{Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease}}, journal = {Oxidative medicine and cellular longevity}, year = {2020}, doi = {10.1155/2020/5086250}, pmid = {32509144}, url = {https://doi.org/10.1155/2020/5086250} } @article{liu2017-29216449, author = {Liu, Chia-Chen and Zhao, Na and Fu, Yuan and Wang, Na and Linares, Cynthia and Tsai, Chih-Wei and Bu, Guojun}, title = {{ApoE4 Accelerates Early Seeding of Amyloid Pathology}}, journal = {Neuron}, year = {2017}, doi = {10.1016/j.neuron.2017.11.013}, pmid = {29216449}, url = {https://doi.org/10.1016/j.neuron.2017.11.013} } @article{kraft2019-30700058, author = {Kraft, Lucas and Serpell, Louise C and Atack, John R}, title = {{A Biophysical Approach to the Identification of Novel ApoE Chemical Probes}}, journal = {Biomolecules}, year = {2019}, doi = {10.3390/biom9020048}, pmid = {30700058}, url = {https://doi.org/10.3390/biom9020048} } @article{abondio2019-30884759, author = {Abondio, Paolo and Sazzini, Marco and Garagnani, Paolo and Boattini, Alessio and Monti, Daniela and Franceschi, Claudio and Luiselli, Donata and Giuliani, Cristina}, title = {{The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity}}, journal = {Genes}, year = {2019}, doi = {10.3390/genes10030222}, pmid = {30884759}, url = {https://doi.org/10.3390/genes10030222} } @article{flory2000-11121165, author = {Flory, J. D. and Manuck, S. B. and Ferrell, R. E. and Ryan, C. M. and Muldoon, M. F.}, title = {{Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults}}, journal = {American journal of medical genetics}, year = {2000}, doi = {10.1002/1096-8628(20001204)96:6<707::aid-ajmg1>3.0.co;2-v}, pmid = {11121165}, url = {https://doi.org/10.1002/1096-8628(20001204)96:6<707::aid-ajmg1>3.0.co;2-v} } @article{frisoni1994-7951679, author = {Frisoni, G. B. and Calabresi, L. and Geroldi, C. and Bianchetti, A. and D'Acquarica, A. L. and Govoni, S. and Sirtori, C. R. and others}, title = {{Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia}}, journal = {Dementia (Basel, Switzerland)}, year = {1994}, doi = {10.1159/000106730}, pmid = {7951679}, url = {https://doi.org/10.1159/000106730} } @article{candore2010-20462385, author = {Candore, G. and Bulati, M. and Caruso, C. and Castiglia, L. and Colonna-Romano, G. and Di Bona, D. and Duro, G. and Lio, D. and others}, title = {{Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications}}, journal = {Rejuvenation research}, year = {2010}, doi = {10.1089/rej.2009.0993}, pmid = {20462385}, url = {https://doi.org/10.1089/rej.2009.0993} } @article{kim2013-22828738, author = {Kim, S. M. and Kim, M. J. and Rhee, H. Y. and Ryu, C. W. and Kim, E. J. and Petersen, E. T. and Jahng, G. H.}, title = {{Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele}}, journal = {Neuroradiology}, year = {2013}, doi = {10.1007/s00234-012-1077-x}, pmid = {22828738}, url = {https://doi.org/10.1007/s00234-012-1077-x} } @article{kurniansyah2025-41434242, author = {Kurniansyah, Nuzulul and Tasaki, Shinya and Zhu, Congcong and Farrell, John Joseph and Rehman, Habbiburr and Sherva, Richard and Hauger, Richard L. and Merritt, Victoria C. and others}, title = {{Hormone replacement therapy in women and vascular risk factors modify the association of a multi‐ancestry polygenic risk score with Alzheimer disease and related traits}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70861_108536}, pmid = {41434242}, url = {https://doi.org/10.1002/alz70861_108536} } @article{bradley2025-41444475, author = {Bradley, Joseph L. and Western, Daniel and Wang, Ciyang and da Fonseca, Eder Lúcio and Neupane, Asmita and Kurup, Jiji Thulaseedhara and Ray, Nicholas R. and Jean‐Francois, Melissa N. and others}, title = {{Novel early‐onset Alzheimer‐associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_107379}, pmid = {41444475}, url = {https://doi.org/10.1002/alz70855_107379} } @article{lin2018-29861287, author = {Lin, Y. T. and Seo, J. and Gao, F. and Feldman, H. M. and Wen, H. L. and Penney, J. and Cam, H. P. and Gjoneska, E. and others}, title = {{APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types}}, journal = {Neuron}, year = {2018}, doi = {10.1016/j.neuron.2018.05.008}, pmid = {29861287}, url = {https://doi.org/10.1016/j.neuron.2018.05.008} } @article{liu2017-28965825, author = {Liu, L. and MacKenzie, K. R. and Putluri, N. and Maletić-Savatić, M. and Bellen, H. J.}, title = {{The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D}}, journal = {Cell metabolism}, year = {2017}, doi = {10.1016/j.cmet.2017.08.024}, pmid = {28965825}, url = {https://doi.org/10.1016/j.cmet.2017.08.024} } @article{belloy2019-30844401, author = {Belloy, M. E. and Napolioni, V. and Greicius, M. D.}, title = {{A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward}}, journal = {Neuron}, year = {2019}, doi = {10.1016/j.neuron.2019.01.056}, pmid = {30844401}, url = {https://doi.org/10.1016/j.neuron.2019.01.056} } @article{huang2017-28111074, author = {Huang, Y. A. and Zhou, B. and Wernig, M. and Südhof, T. C.}, title = {{ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion}}, journal = {Cell}, year = {2017}, doi = {10.1016/j.cell.2016.12.044}, pmid = {28111074}, url = {https://doi.org/10.1016/j.cell.2016.12.044} } @article{strittmatter1996-8833436, author = {Strittmatter, W J and Roses, A D}, title = {{Apolipoprotein E and Alzheimer's disease}}, journal = {Annual review of neuroscience}, year = {1996}, doi = {10.1146/annurev.ne.19.030196.000413}, pmid = {8833436}, url = {https://doi.org/10.1146/annurev.ne.19.030196.000413} } @article{nishimura2014-24992828, author = {Nishimura, Motoi and Satoh, Mamoru and Matsushita, Kazuyuki and Nomura, Fumio}, title = {{How proteomic ApoE serotyping could impact Alzheimer's disease risk assessment: genetic testing by proteomics}}, journal = {Expert review of proteomics}, year = {2014}, doi = {10.1586/14789450.2014.936390}, pmid = {24992828}, url = {https://doi.org/10.1586/14789450.2014.936390} } @article{dose2016-27457486, author = {Dose, Janina and Huebbe, Patricia and Nebel, Almut and Rimbach, Gerald}, title = {{APOE genotype and stress response - a mini review}}, journal = {Lipids in health and disease}, year = {2016}, doi = {10.1186/s12944-016-0288-2}, pmid = {27457486}, url = {https://doi.org/10.1186/s12944-016-0288-2} } @article{spagnuolo2014-25058565, author = {Spagnuolo, Maria Stefania and Maresca, Bernardetta and La Marca, Valeria and Carrizzo, Albino and Veronesi, Carlo and Cupidi, Chiara and Piccoli, Tommaso and Maletta, Raffaele Giovanni and others}, title = {{Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk}}, journal = {ACS chemical neuroscience}, year = {2014}, doi = {10.1021/cn500099f}, pmid = {25058565}, url = {https://doi.org/10.1021/cn500099f} } @article{mahley2016-27277824, author = {Mahley, Robert W}, title = {{Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders}}, journal = {Journal of molecular medicine (Berlin, Germany)}, year = {2016}, doi = {10.1007/s00109-016-1427-y}, pmid = {27277824}, url = {https://doi.org/10.1007/s00109-016-1427-y} } @article{esler2002-12000192, author = {Esler, William P and Marshall, Jeffrey R and Stimson, Evelyn R and Ghilardi, Joseph R and Vinters, Harry V and Mantyh, Patrick W and Maggio, John E}, title = {{Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease}}, journal = {Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis}, year = {2002}, doi = {10.3109/13506120209072439}, pmid = {12000192}, url = {https://doi.org/10.3109/13506120209072439} } @article{chou2006-16540478, author = {Chou, Chi-Yuan and Jen, Wei-Ping and Hsieh, Yi-Hui and Shiao, Ming-Shi and Chang, Gu-Gang}, title = {{Structural and functional variations in human apolipoprotein E3 and E4}}, journal = {The Journal of biological chemistry}, year = {2006}, doi = {10.1074/jbc.m511077200}, pmid = {16540478}, url = {https://doi.org/10.1074/jbc.m511077200} } @article{andres2011-21184197, author = {Andres, Marilou A and Feger, Ute and Nath, Avindra and Munsaka, Sody and Jiang, Caroline S and Chang, Linda}, title = {{APOE ε 4 allele and CSF APOE on cognition in HIV-infected subjects}}, journal = {Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology}, year = {2011}, doi = {10.1007/s11481-010-9254-3}, pmid = {21184197}, url = {https://doi.org/10.1007/s11481-010-9254-3} } @article{fu2016-27151330, author = {Fu, Yuan and Zhao, Jing and Atagi, Yuka and Nielsen, Henrietta M and Liu, Chia-Chen and Zheng, Honghua and Shinohara, Mitsuru and Kanekiyo, Takahisa and others}, title = {{Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan}}, journal = {Molecular neurodegeneration}, year = {2016}, doi = {10.1186/s13024-016-0099-y}, pmid = {27151330}, url = {https://doi.org/10.1186/s13024-016-0099-y} } @article{huang2010-20531185, author = {Huang, Yadong}, title = {{Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases}}, journal = {Current opinion in lipidology}, year = {2010}, doi = {10.1097/mol.0b013e32833af368}, pmid = {20531185}, url = {https://doi.org/10.1097/mol.0b013e32833af368} } @article{raber2004-15028864, author = {Raber, Jacob}, title = {{Androgens, apoE, and Alzheimer's disease}}, journal = {Science of aging knowledge environment : SAGE KE}, year = {2004}, doi = {10.1126/sageke.2004.11.re2}, pmid = {15028864}, url = {https://doi.org/10.1126/sageke.2004.11.re2} } @article{hone2005-16131732, author = {Hone, E and Martins, I J and Jeoung, M and Ji, T H and Gandy, S E and Martins, R N}, title = {{Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2005}, doi = {10.3233/jad-2005-7406}, pmid = {16131732}, url = {https://doi.org/10.3233/jad-2005-7406} } @article{poirier1995-8652146, author = {Poirier, J and Minnich, A and Davignon, J}, title = {{Apolipoprotein E, synaptic plasticity and Alzheimer's disease}}, journal = {Annals of medicine}, year = {1995}, doi = {10.3109/07853899509019253}, pmid = {8652146}, url = {https://doi.org/10.3109/07853899509019253} } @article{villasana2006-17149978, author = {Villasana, Laura and Acevedo, Summer and Poage, Cara and Raber, Jacob}, title = {{Sex- and APOE isoform-dependent effects of radiation on cognitive function}}, journal = {Radiation research}, year = {2006}, doi = {10.1667/rr0642.1}, pmid = {17149978}, url = {https://doi.org/10.1667/rr0642.1} } @article{elliott2010-20170526, author = {Elliott, David A and Halliday, Glenda M and Garner, Brett}, title = {{Apolipoprotein-E forms dimers in human frontal cortex and hippocampus}}, journal = {BMC neuroscience}, year = {2010}, doi = {10.1186/1471-2202-11-23}, pmid = {20170526}, url = {https://doi.org/10.1186/1471-2202-11-23} } @article{lopez2014-24754513, author = {Lopez, Mary F and Krastins, Bryan and Ning, MingMing}, title = {{The role of apolipoprotein E in neurodegeneration and cardiovascular disease}}, journal = {Expert review of proteomics}, year = {2014}, doi = {10.1586/14789450.2014.901892}, pmid = {24754513}, url = {https://doi.org/10.1586/14789450.2014.901892} } @article{baum2000-10936880, author = {Baum, L and Chen, L and Ng, H K and Pang, C P}, title = {{Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology}}, journal = {Microscopy research and technique}, year = {2000}, doi = {10.1002/1097-0029(20000815)50:4<278::aid-jemt5>3.0.co;2-t}, pmid = {10936880}, url = {https://doi.org/10.1002/1097-0029(20000815)50:4<278::aid-jemt5>3.0.co;2-t} } @article{folin2004-15375590, author = {Folin, Marcella and Baiguera, Silvia and Conconi, Maria Teresa and Di Liddo, Rosa and De Carlo, Eugenio and Parnigotto, Pier Paolo and Nussdorfer, Gastone G}, title = {{Apolipoprotein E as vascular risk factor in neurodegenerative dementia}}, journal = {International journal of molecular medicine}, year = {2004}, pmid = {15375590} } @article{mahley2012-23217737, author = {Mahley, Robert W and Huang, Yadong}, title = {{Apolipoprotein e sets the stage: response to injury triggers neuropathology}}, journal = {Neuron}, year = {2012}, doi = {10.1016/j.neuron.2012.11.020}, pmid = {23217737}, url = {https://doi.org/10.1016/j.neuron.2012.11.020} } @article{montine1996-8786379, author = {Montine, T J and Huang, D Y and Valentine, W M and Amarnath, V and Saunders, A and Weisgraber, K H and Graham, D G and Strittmatter, W J}, title = {{Crosslinking of apolipoprotein E by products of lipid peroxidation}}, journal = {Journal of neuropathology and experimental neurology}, year = {1996}, doi = {10.1097/00005072-199602000-00009}, pmid = {8786379}, url = {https://doi.org/10.1097/00005072-199602000-00009} } @article{zhu2012-22228589, author = {Zhu, Yuangui and Nwabuisi-Heath, Evelyn and Dumanis, Sonya B and Tai, Leon M and Yu, Chunjiang and Rebeck, G William and LaDu, Mary Jo}, title = {{APOE genotype alters glial activation and loss of synaptic markers in mice}}, journal = {Glia}, year = {2012}, doi = {10.1002/glia.22289}, pmid = {22228589}, url = {https://doi.org/10.1002/glia.22289} } @article{jawaid2011-20880000, author = {Jawaid, A and Poon, M and Strutt, A M and Rice, L K and McDowell, E J and Salamone, A R and Qureshi, S U and Simpson, E and others}, title = {{Does apolipoprotein E genotype modify the clinical expression of ALS?}}, journal = {European journal of neurology}, year = {2011}, doi = {10.1111/j.1468-1331.2010.03225.x}, pmid = {20880000}, url = {https://doi.org/10.1111/j.1468-1331.2010.03225.x} } @article{oyama1995-7770005, author = {Oyama, F and Shimada, H and Oyama, R and Ihara, Y}, title = {{Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population}}, journal = {Brain research. Molecular brain research}, year = {1995}, doi = {10.1016/0169-328x(94)00233-5}, pmid = {7770005}, url = {https://doi.org/10.1016/0169-328x(94)00233-5} } @article{newhouse2011-20967588, author = {Newhouse, Yvonne and Weisgraber, Karl H}, title = {{Apolipoprotein E expression and purification}}, journal = {Methods in molecular biology (Clifton, N.J.)}, year = {2011}, doi = {10.1007/978-1-60761-744-0_10}, pmid = {20967588}, url = {https://doi.org/10.1007/978-1-60761-744-0_10} } @article{teter1999-10582625, author = {Teter, B and Xu, P T and Gilbert, J R and Roses, A D and Galasko, D and Cole, G M}, title = {{Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture}}, journal = {Journal of neurochemistry}, year = {1999}, doi = {10.1046/j.1471-4159.1999.0732613.x}, pmid = {10582625}, url = {https://doi.org/10.1046/j.1471-4159.1999.0732613.x} } @article{guo2004-15181248, author = {Guo, Ling and LaDu, Mary Jo and Van Eldik, Linda J}, title = {{A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity}}, journal = {Journal of molecular neuroscience : MN}, year = {2004}, doi = {10.1385/jmn:23:3:205}, pmid = {15181248}, url = {https://doi.org/10.1385/jmn:23:3:205} } @article{ladu1997-9211985, author = {LaDu, M J and Lukens, J R and Reardon, C A and Getz, G S}, title = {{Association of human, rat, and rabbit apolipoprotein E with beta-amyloid}}, journal = {Journal of neuroscience research}, year = {1997}, pmid = {9211985} } @article{morrow1999-10419818, author = {Morrow, J A and Arnold, K S and Weisgraber, K H}, title = {{Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli}}, journal = {Protein expression and purification}, year = {1999}, doi = {10.1006/prep.1999.1069}, pmid = {10419818}, url = {https://doi.org/10.1006/prep.1999.1069} } @article{dorey2014-24652457, author = {Dorey, Evan and Chang, Nina and Liu, Qing Yan and Yang, Ze and Zhang, Wandong}, title = {{Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease}}, journal = {Neuroscience bulletin}, year = {2014}, doi = {10.1007/s12264-013-1422-z}, pmid = {24652457}, url = {https://doi.org/10.1007/s12264-013-1422-z} } @article{dodd2026-c8ae3fc8, author = {Dodd, Roger B. and Enomoto, Masahiro and Zhou, Ye and Satoh, Kanayo and Zhang, Yalun and Chen, Fusheng and Acheson, Beatrice and Ghaffari, Deniz and others}, title = {{CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk}}, journal = {DOAJ (DOAJ: Directory of Open Access Journals)}, year = {2026}, doi = {10.1038/s41467-026-75140-3}, url = {https://doi.org/10.1038/s41467-026-75140-3} } @article{moore2025-41439341, author = {Moore, Noel C. and Song, Yeunjoo E. and Gulyayev, Alex V. and Miskimen, Kristy L. S. and Laux, Reneé A. and Lynn, Audrey H. and Fuzzell, Sarada L. and Hochstetler, Sherri D. and others}, title = {{Investigating the effects of complement loci CFH and ARMS2/HTRA1 on Alzheimer Disease}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_106578}, pmid = {41439341}, url = {https://doi.org/10.1002/alz70855_106578} } @article{mcgill2025-40494894, author = {McGill, Cassandra Joan and Christensen, Amy and Qian, Wenjie and Thorwald, Max Andrew and Godoy-Lugo, José Arquimides and Namvari, Sara and White, Olivia S. and Finch, Caleb E. and others}, title = {{Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice}}, journal = {Communications Medicine}, year = {2025}, doi = {10.1038/s43856-025-00942-3}, pmid = {40494894}, url = {https://doi.org/10.1038/s43856-025-00942-3} } @article{christensen2025-41435356, author = {Christensen, Amy and McGill, Cassandra Joan and Zaidi, Ali Hussainy and Pike, Christian J.}, title = {{Alzheimer‐related neuropathology is improved by treatment with longevity‐enhancing treatments in aged male EFAD mice}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_099102}, pmid = {41435356}, url = {https://doi.org/10.1002/alz70855_099102} } @article{zhang2026-41490095, author = {Zhang, Xiaoling and Xie, Guomin and Zhao, Cui and Lv, Zhongyue}, title = {{Plasma lipid subspecies and Alzheimer’s disease: genetic evidence for risk and protection}}, journal = {QJM}, year = {2026}, doi = {10.1093/qjmed/hcag006}, pmid = {41490095}, url = {https://doi.org/10.1093/qjmed/hcag006} } @article{levinallerhand2002-12474021, author = {Levin-Allerhand, J. A. and Lominska, C. E. and Smith, J. D.}, title = {{Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet}}, journal = {The journal of nutrition, health \& aging}, year = {2002}, pmid = {12474021} } @article{manca2025-40851051, author = {Manca, Riccardo and Mitolo, Micaela and Bacalini, Maria Giulia and Capellari, Sabina and Venneri, Annalena}, title = {{The impact of polygenic risk for alzheimer’s disease on neurotransmitter-related grey matter atrophy in the alzheimer continuum}}, journal = {Neurological Sciences}, year = {2025}, doi = {10.1007/s10072-025-08393-3}, pmid = {40851051}, url = {https://doi.org/10.1007/s10072-025-08393-3} } @article{yu2026-41961648, author = {Yu, Zhong and Hao, Lu and Zhang, Haofuzi}, title = {{Mendelian randomization study of genetic interactions between Alzheimer disease and celiac disease}}, journal = {Medicine}, year = {2026}, doi = {10.1097/md.0000000000048320}, pmid = {41961648}, url = {https://doi.org/10.1097/md.0000000000048320} } @article{mahley2000-11701639, author = {Mahley, R. W. and Rall, S. C.}, title = {{Apolipoprotein E: far more than a lipid transport protein}}, journal = {Annual review of genomics and human genetics}, year = {2000}, doi = {10.1146/annurev.genom.1.1.507}, pmid = {11701639}, url = {https://doi.org/10.1146/annurev.genom.1.1.507} } @article{jiang2008-18549781, author = {Jiang, Q. and Lee, C. Y. and Mandrekar, S. and Wilkinson, B. and Cramer, P. and Zelcer, N. and Mann, K. and Lamb, B. and others}, title = {{ApoE promotes the proteolytic degradation of Abeta}}, journal = {Neuron}, year = {2008}, doi = {10.1016/j.neuron.2008.04.010}, pmid = {18549781}, url = {https://doi.org/10.1016/j.neuron.2008.04.010} }