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% Source: https://alzhub.org/research?category=drug_development&access=free
% 52 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{boon2025-41109234,
  author  = {Boon, B. D. C. and Piura, Y. D. and Moloney, C. M. and Chalk, J. L. and Lincoln, S. J. and Rutledge, M. H. and Rothberg, D. M. and Kouri, N. and others},
  title   = {{Neuropathological changes and amyloid-related imaging abnormalities in Alzheimer's disease treated with aducanumab versus untreated: a retrospective case-control study}},
  journal = {The Lancet. Neurology},
  year    = {2025},
  doi     = {10.1016/s1474-4422(25)00313-8},
  pmid    = {41109234},
  url     = {https://doi.org/10.1016/s1474-4422(25)00313-8}
}

@article{rosenberg2022-36130840,
  author  = {Rosenberg, A. and Öhlund-Wistbacka, U. and Hall, A. and Bonnard, A. and Hagman, G. and Rydén, M. and Thunborg, C. and Wiggenraad, F. and others},
  title   = {{β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000201043},
  pmid    = {36130840},
  url     = {https://doi.org/10.1212/wnl.0000000000201043}
}

@article{jeremic2025-40194268,
  author  = {Jeremic, D. and Navarro-Lopez, J. D. and Jimenez-Diaz, L.},
  title   = {{Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application}},
  journal = {Journal of medical Internet research},
  year    = {2025},
  doi     = {10.2196/68454},
  pmid    = {40194268},
  url     = {https://doi.org/10.2196/68454}
}

@article{worrall2026-1bda82c8,
  author  = {Worrall, Bradford B. and Ratan, Rajiv R.},
  title   = {{What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia?}},
  journal = {Neurology Genetics},
  year    = {2026},
  doi     = {10.1212/nxg.0000000000200450},
  url     = {https://doi.org/10.1212/nxg.0000000000200450}
}

@article{pittock2023-37586881,
  author  = {Pittock, R. R. and Aakre, J. A. and Castillo, A. M. and Ramanan, V. K. and Kremers, W. K. and Jack, C. R. and Vemuri, P. and Lowe, V. J. and others},
  title   = {{Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging}},
  journal = {Neurology},
  year    = {2023},
  doi     = {10.1212/wnl.0000000000207770},
  pmid    = {37586881},
  url     = {https://doi.org/10.1212/wnl.0000000000207770}
}

@article{loomis2024-38165296,
  author  = {Loomis, S. J. and Miller, R. and Castrillo-Viguera, C. and Umans, K. and Cheng, W. and O'Gorman, J. and Hughes, R. and Budd Haeberlein, S. and others},
  title   = {{Genome-Wide Association Studies of ARIA From the Aducanumab Phase 3 ENGAGE and EMERGE Studies}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000207919},
  pmid    = {38165296},
  url     = {https://doi.org/10.1212/wnl.0000000000207919}
}

@article{karran2022-35177833,
  author  = {Karran, E. and De Strooper, B.},
  title   = {{The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics}},
  journal = {Nature reviews. Drug discovery},
  year    = {2022},
  doi     = {10.1038/s41573-022-00391-w},
  pmid    = {35177833},
  url     = {https://doi.org/10.1038/s41573-022-00391-w}
}

@article{nasir2026-42636218,
  author  = {Nasir, Ahmad Basil and Kilani, Yassine and Aldiabat, Mohammad and Abdelghany, Omar and Hafez, Youssef and Desai, Nitin and Madi, Mahmoud Y. and Wade, Francis G. and others},
  title   = {{Antidiabetic medications and risk of cognitive disorders in type 2 diabetes: A retrospective cohort study}},
  journal = {PLoS ONE},
  year    = {2026},
  doi     = {10.1371/journal.pone.0356138},
  pmid    = {42636218},
  url     = {https://doi.org/10.1371/journal.pone.0356138}
}

@article{brown2026-42437499,
  author  = {Brown, C. A. and Robinson, J. L. and Das, SR. and McGrew, E. and Suh, E. and Van Deerlin, V. M. and Irwin, D. J. and Nasrallah, I. M. and others},
  title   = {{Clinicopathologic Evaluation of Amyloid Clearance in Alzheimer Disease}},
  journal = {JAMA},
  year    = {2026},
  doi     = {10.1001/jama.2026.13058},
  pmid    = {42437499},
  url     = {https://doi.org/10.1001/jama.2026.13058}
}

@article{sima2024-38345816,
  author  = {Sima, D. M. and Phan, T. V. and Van Eyndhoven, S. and Vercruyssen, S. and Magalhães, R. and Liseune, A. and Brys, A. and Frenyo, P. and others},
  title   = {{Artificial Intelligence Assistive Software Tool for Automated Detection and Quantification of Amyloid-Related Imaging Abnormalities}},
  journal = {JAMA network open},
  year    = {2024},
  doi     = {10.1001/jamanetworkopen.2023.55800},
  pmid    = {38345816},
  url     = {https://doi.org/10.1001/jamanetworkopen.2023.55800}
}

@article{huang2023-37784171,
  author  = {Huang, L. K. and Kuan, Y. C. and Lin, H. W. and Hu, C. J.},
  title   = {{Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update}},
  journal = {Journal of biomedical science},
  year    = {2023},
  doi     = {10.1186/s12929-023-00976-6},
  pmid    = {37784171},
  url     = {https://doi.org/10.1186/s12929-023-00976-6}
}

@article{kim2024-38868666,
  author  = {Kim, A. Y. and Al Jerdi, S. and MacDonald, R. and Triggle, C. R.},
  title   = {{Alzheimer's disease and its treatment-yesterday, today, and tomorrow}},
  journal = {Frontiers in pharmacology},
  year    = {2024},
  doi     = {10.3389/fphar.2024.1399121},
  pmid    = {38868666},
  url     = {https://doi.org/10.3389/fphar.2024.1399121}
}

@article{uhlmann2020-33199898,
  author  = {Uhlmann, R. E. and Rother, C. and Rasmussen, J. and Schelle, J. and Bergmann, C. and Ullrich Gavilanes, E. M. and Fritschi, S. K. and Buehler, A. and others},
  title   = {{Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life}},
  journal = {Nature neuroscience},
  year    = {2020},
  doi     = {10.1038/s41593-020-00737-w},
  pmid    = {33199898},
  url     = {https://doi.org/10.1038/s41593-020-00737-w}
}

@article{sveikata2022-34905943,
  author  = {Sveikata, L. and Charidimou, A. and Viswanathan, A.},
  title   = {{Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab}},
  journal = {Stroke},
  year    = {2022},
  doi     = {10.1161/strokeaha.121.036873},
  pmid    = {34905943},
  url     = {https://doi.org/10.1161/strokeaha.121.036873}
}

@article{alvarado2024-38181731,
  author  = {Alvarado, C. X. and Makarious, M. B. and Weller, C. A. and Vitale, D. and Koretsky, M. J. and Bandres-Ciga, S. and Iwaki, H. and Levine, K. and others},
  title   = {{omicSynth: An open multi-omic community resource for identifying druggable targets across neurodegenerative diseases}},
  journal = {American journal of human genetics},
  year    = {2024},
  doi     = {10.1016/j.ajhg.2023.12.006},
  pmid    = {38181731},
  url     = {https://doi.org/10.1016/j.ajhg.2023.12.006}
}

@article{vitek2023-36749830,
  author  = {Vitek, G. E. and Decourt, B. and Sabbagh, M. N.},
  title   = {{Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease}},
  journal = {Expert opinion on investigational drugs},
  year    = {2023},
  doi     = {10.1080/13543784.2023.2178414},
  pmid    = {36749830},
  url     = {https://doi.org/10.1080/13543784.2023.2178414}
}

@article{holscher2024-38677445,
  author  = {Hölscher, C.},
  title   = {{Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?}},
  journal = {Neuropharmacology},
  year    = {2024},
  doi     = {10.1016/j.neuropharm.2024.109952},
  pmid    = {38677445},
  url     = {https://doi.org/10.1016/j.neuropharm.2024.109952}
}

@article{liu2021-34535787,
  author  = {Liu, K. Y. and Howard, R.},
  title   = {{Can we learn lessons from the FDA's approval of aducanumab?}},
  journal = {Nature reviews. Neurology},
  year    = {2021},
  doi     = {10.1038/s41582-021-00557-x},
  pmid    = {34535787},
  url     = {https://doi.org/10.1038/s41582-021-00557-x}
}

@article{leinenga2021-33836798,
  author  = {Leinenga, G. and Koh, W. K. and Götz, J.},
  title   = {{A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00809-4},
  pmid    = {33836798},
  url     = {https://doi.org/10.1186/s13195-021-00809-4}
}

@article{morato2022-36012569,
  author  = {Morató, X. and Pytel, V. and Jofresa, S. and Ruiz, A. and Boada, M.},
  title   = {{Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimer's Disease: Towards a Personalized Polypharmacology Patient-Centered Approach}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23169305},
  pmid    = {36012569},
  url     = {https://doi.org/10.3390/ijms23169305}
}

@article{abdallah2024-38586442,
  author  = {Abdallah, A. E.},
  title   = {{Review on anti-alzheimer drug development: approaches, challenges and perspectives}},
  journal = {RSC advances},
  year    = {2024},
  doi     = {10.1039/d3ra08333k},
  pmid    = {38586442},
  url     = {https://doi.org/10.1039/d3ra08333k}
}

@article{szeszko2026-ffbf0b6d,
  author  = {Szeszko, Anna Maria and Lubowiecka, Małgorzata and Czernek, Weronika Maria and Cichorzewska, Magdalena and Płachta, Martyna and Wojtan, Rafał},
  title   = {{GLP-1-BASED THERAPIES BEYOND DIABETES: EMERGING CLINICAL APPLICATIONS AND FUTURE PERSPECTIVES}},
  journal = {Archiv Euromedica},
  year    = {2026},
  doi     = {10.35630/2026/16/iss.4.14},
  url     = {https://doi.org/10.35630/2026/16/iss.4.14}
}

@article{leyhe2020-33277912,
  author  = {Leyhe, T. and Jucker, M. and Nef, T. and Sollberger, M. and Riese, F. and Haba-Rubio, J. and Verloo, H. and Lüthi, R. and others},
  title   = {{Conference report: dementia research and care and its impact in Switzerland}},
  journal = {Swiss medical weekly},
  year    = {2020},
  doi     = {10.4414/smw.2020.20376},
  pmid    = {33277912},
  url     = {https://doi.org/10.4414/smw.2020.20376}
}

@article{cheng2017-28356312,
  author  = {Cheng, Y. S. and Chen, Z. T. and Liao, T. Y. and Lin, C. and Shen, H. C. and Wang, Y. H. and Chang, C. W. and Liu, R. S. and others},
  title   = {{An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201606666},
  pmid    = {28356312},
  url     = {https://doi.org/10.15252/emmm.201606666}
}

@article{decourt2022-36339394,
  author  = {Decourt, B. and Noorda, K. and Shi, J. and Sabbagh, M. N.},
  title   = {{Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia}},
  journal = {Journal of experimental pharmacology},
  year    = {2022},
  doi     = {10.2147/jep.s265626},
  pmid    = {36339394},
  url     = {https://doi.org/10.2147/jep.s265626}
}

@article{waite2024-38962384,
  author  = {Waite, L. M.},
  title   = {{New and emerging drug therapies for Alzheimer disease}},
  journal = {Australian prescriber},
  year    = {2024},
  doi     = {10.18773/austprescr.2024.021},
  pmid    = {38962384},
  url     = {https://doi.org/10.18773/austprescr.2024.021}
}

@article{gouveri2024-37950798,
  author  = {Gouveri, E. and Popovic, D. S. and Papanas, N.},
  title   = {{Potential New Therapeutic Implications of Semaglutide: New Colours of the Rainbow?}},
  journal = {Diabetes therapy : research, treatment and education of diabetes and related disorders},
  year    = {2024},
  doi     = {10.1007/s13300-023-01506-1},
  pmid    = {37950798},
  url     = {https://doi.org/10.1007/s13300-023-01506-1}
}

@article{gao2014-24329968,
  author  = {Gao, C. and Liu, Y. and Jiang, Y. and Ding, J. and Li, L.},
  title   = {{Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2014},
  doi     = {10.1111/bpa.12116},
  pmid    = {24329968},
  url     = {https://doi.org/10.1111/bpa.12116}
}

@article{chen2012-21901364,
  author  = {Chen, S. and Liu, A. R. and An, F. M. and Yao, W. B. and Gao, X. D.},
  title   = {{Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4}},
  journal = {Age (Dordrecht, Netherlands)},
  year    = {2012},
  doi     = {10.1007/s11357-011-9303-8},
  pmid    = {21901364},
  url     = {https://doi.org/10.1007/s11357-011-9303-8}
}

@article{zhang2018-30318466,
  author  = {Zhang, H. and Zhu, X. and Pascual, G. and Wadia, J. S. and Keogh, E. and Hoozemans, J. J. and Siregar, B. and Inganäs, H. and others},
  title   = {{Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody}},
  journal = {Structure (London, England : 1993)},
  year    = {2018},
  doi     = {10.1016/j.str.2018.08.012},
  pmid    = {30318466},
  url     = {https://doi.org/10.1016/j.str.2018.08.012}
}

@article{dangpiaei2026-41885326,
  author  = {Dangpiaei, S. and Kamal, K. M. and Shoair, O. A. and Al-Mamun, M. A.},
  title   = {{Incidence of amyloid-related imaging abnormalities and health resource utilization in patients with Alzheimer disease receiving monoclonal antibody treatments: A real-world evidence study}},
  journal = {Journal of managed care \& specialty pharmacy},
  year    = {2026},
  doi     = {10.18553/jmcp.2026.32.4.470},
  pmid    = {41885326},
  url     = {https://doi.org/10.18553/jmcp.2026.32.4.470}
}

@article{deleye2017-28611242,
  author  = {Deleye, S. and Waldron, A. M. and Verhaeghe, J. and Bottelbergs, A. and Wyffels, L. and Van Broeck, B. and Langlois, X. and Schmidt, M. and others},
  title   = {{Evaluation of Small-Animal PET Outcome Measures to Detect Disease Modification Induced by BACE Inhibition in a Transgenic Mouse Model of Alzheimer Disease}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2017},
  doi     = {10.2967/jnumed.116.187625},
  pmid    = {28611242},
  url     = {https://doi.org/10.2967/jnumed.116.187625}
}

@article{tayeb2023-37045461,
  author  = {Tayeb, H. O. and Khallaf, R. A. and Muayqil, T. A. and Alkeridy, W. A. and Alibrahim, F. S. and Alfaify, O. A. and Qadi, N. and Tarazi, F. I.},
  title   = {{The future of alzheimer disease immunotherapies in Saudi Arabia: Consensus statement of the Saudi Chapter of Cognitive and Behavioral Neurology}},
  journal = {Neurosciences (Riyadh, Saudi Arabia)},
  year    = {2023},
  doi     = {10.17712/nsj.2023.2.20220133},
  pmid    = {37045461},
  url     = {https://doi.org/10.17712/nsj.2023.2.20220133}
}

@article{beckmann2016-27459925,
  author  = {Beckmann, N. and Doelemeyer, A. and Zurbruegg, S. and Bigot, K. and Theil, D. and Frieauff, W. and Kolly, C. and Moulin, P. and others},
  title   = {{Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.05.009},
  pmid    = {27459925},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.05.009}
}

@article{barenholtzlevy2022-34595939,
  author  = {Barenholtz Levy, H.},
  title   = {{Accelerated Approval of Aducanumab: Where Do We Stand Now?}},
  journal = {The Annals of pharmacotherapy},
  year    = {2022},
  doi     = {10.1177/10600280211050405},
  pmid    = {34595939},
  url     = {https://doi.org/10.1177/10600280211050405}
}

@article{coerver2022-35733944,
  author  = {Coerver, K. and Yu, M. M. and D'Abreu, A. and Wasserman, M. and Nair, K. V.},
  title   = {{Practical Considerations in the Administration of Aducanumab for the Neurologist}},
  journal = {Neurology. Clinical practice},
  year    = {2022},
  doi     = {10.1212/cpj.0000000000001144},
  pmid    = {35733944},
  url     = {https://doi.org/10.1212/cpj.0000000000001144}
}

@article{hoilundcarlsen2022-35452007,
  author  = {Høilund-Carlsen, P. F. and Werner, T. J. and Alavi, A. and Revheim, M. E.},
  title   = {{Aducanumab-Related Amyloid-Related Imaging Abnormalities: Paean or Lament?}},
  journal = {Clinical nuclear medicine},
  year    = {2022},
  doi     = {10.1097/rlu.0000000000004250},
  pmid    = {35452007},
  url     = {https://doi.org/10.1097/rlu.0000000000004250}
}

@article{caro2026-dd11f0ff,
  author  = {Caro, Ilana and Sargurupremraj, Muralidharan and Yang, Chengran and Akinleye, Callistus A. and Trégouët, David‐Alexandre and Akinyemi, Rufus and Shigemizu, Daichi and Coker, Motunrayo Mojoyin and others},
  title   = {{Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries}},
  journal = {Neurology Genetics},
  year    = {2026},
  doi     = {10.1212/nxg.0000000000200425},
  url     = {https://doi.org/10.1212/nxg.0000000000200425}
}

@article{raja2026-d1c44bbc,
  author  = {Raja, Michelle and Patel, Khush and Krish, Pranav and Chow, Chrissy and Azam, Zaki},
  title   = {{GLP-1 Receptor Agonists Beyond Glycemic Control: Clinical Implications in Neurodegenerative Disease and Substance Use Disorders}},
  journal = {Journal of Community Hospital Internal Medicine Perspectives},
  year    = {2026},
  doi     = {10.55729/2000-9666.1651},
  url     = {https://doi.org/10.55729/2000-9666.1651}
}

@article{doherty2022-35622461,
  author  = {Doherty, T. and Gee, M. and Maruff, P. and Smith, R. and Murphy, J. and Marsh, J. and Koschalka, L. and Martinez, M. and others},
  title   = {{Increasing the Cognitive Screening Efficiency of Global Phase III Trials in Early Alzheimer Disease: The Cognitive Task Force}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2022},
  doi     = {10.1097/wad.0000000000000508},
  pmid    = {35622461},
  url     = {https://doi.org/10.1097/wad.0000000000000508}
}

@article{salehiabargouei2025-40356047,
  author  = {Salehi‐Abargouei, Amin and Muka, Taulant and Collet, Tinh‐Hai and Kepp, Kasper P. and Chatelan, Angéline},
  title   = {{Comment on “Associations of semaglutide with first‐time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real‐world data in the US”}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70035},
  pmid    = {40356047},
  url     = {https://doi.org/10.1002/alz.70035}
}

@article{sharma2026-0b097590,
  author  = {Sharma, Shubham and Veeranki, Phani and Mubayi, Dr Anuj and Nambari, Santosh},
  title   = {{Real-World Evidence of GLP-1 Receptor Agonist in Neurodegenerative Disorder: A Scoping Review of Observational Studies}},
  journal = {Open Science Framework},
  year    = {2026},
  doi     = {10.17605/osf.io/ng7mu},
  url     = {https://doi.org/10.17605/osf.io/ng7mu}
}

@article{anderson2022-36576369,
  author  = {Anderson, A. and Malone, M.},
  title   = {{The Differential Diagnosis and Treatment of Mild Cognitive Impairment and Alzheimer Disease}},
  journal = {The Journal of clinical psychiatry},
  year    = {2022},
  doi     = {10.4088/jcp.bg21120com4},
  pmid    = {36576369},
  url     = {https://doi.org/10.4088/jcp.bg21120com4}
}

@article{kurkinen2021-34313409,
  author  = {Kurkinen, M.},
  title   = {{Alzheimer's trials: A cul-de-sac with no end in sight}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2021},
  doi     = {10.17219/acem/139501},
  pmid    = {34313409},
  url     = {https://doi.org/10.17219/acem/139501}
}

@article{simoni2026-41561789,
  author  = {Simoni, Zack and Hilfiker, Victoria},
  title   = {{The social construction of Aduhelm in the context of pharmaceutical ambiguity: exploring narratives from informal caregivers, medical professionals, and redditors on r/Alzheimers}},
  journal = {Frontiers in Sociology},
  year    = {2026},
  doi     = {10.3389/fsoc.2025.1636160},
  pmid    = {41561789},
  url     = {https://doi.org/10.3389/fsoc.2025.1636160}
}

@article{gomezvirgilio2022-36256566,
  author  = {Gómez-Virgilio, L. and Reyes-Gutiérrez, G. S. and Silva-Lucero, M. D. and López-Toledo, G. and Cárdenas-Aguayo, M. D.},
  title   = {{Etiology, risk factors, treatments and current status of Alzheimer's disease in Mexico}},
  journal = {Gaceta medica de Mexico},
  year    = {2022},
  doi     = {10.24875/gmm.m22000681},
  pmid    = {36256566},
  url     = {https://doi.org/10.24875/gmm.m22000681}
}

@article{hager2022-35288774,
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@article{tsoy2025-48774eb9,
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@article{day2022-35197360,
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  year    = {2022},
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@article{wang2026-dbbc063a,
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@article{butler2025-35ab99e8,
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  year    = {2025},
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@article{ferrari2024-a3b419d0,
  author  = {Ferrari, IV.},
  title   = {{Exploring Natural Compounds for Alzheimer's Disease: Virtual Screening and Docking Study with KIBRA Protein}},
  journal = {Preprints.org},
  year    = {2024},
  doi     = {10.20944/preprints202402.0232.v1},
  url     = {https://doi.org/10.20944/preprints202402.0232.v1}
}