% alzhub.org library filter % Source: https://alzhub.org/research?access=free&atag=small % 500 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{debette2019-30422209, author = {Debette, S. and Schilling, S. and Duperron, M. G. and Larsson, S. C. and Markus, H. S.}, title = {{Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2018.3122}, pmid = {30422209}, url = {https://doi.org/10.1001/jamaneurol.2018.3122} } @article{rensma2018-29656031, author = {Rensma, S. P. and van Sloten, T. T. and Launer, L. J. and Stehouwer, C. D. A.}, title = {{Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis}}, journal = {Neuroscience and biobehavioral reviews}, year = {2018}, doi = {10.1016/j.neubiorev.2018.04.003}, pmid = {29656031}, url = {https://doi.org/10.1016/j.neubiorev.2018.04.003} } @article{hilal2018-30068634, author = {Hilal, S. and Tan, C. S. and Adams, H. H. H. and Habes, M. and Mok, V. and Venketasubramanian, N. and Hofer, E. and Ikram, M. K. and others}, title = {{Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006079}, pmid = {30068634}, url = {https://doi.org/10.1212/wnl.0000000000006079} } @article{fornage2011-21681796, author = {Fornage, M. and Debette, S. and Bis, J. C. and Schmidt, H. and Ikram, M. A. and Dufouil, C. and Sigurdsson, S. and Lumley, T. and others}, title = {{Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22403}, pmid = {21681796}, url = {https://doi.org/10.1002/ana.22403} } @article{shi2016-27496552, author = {Shi, Y. and Thrippleton, M. J. and Makin, S. D. and Marshall, I. and Geerlings, M. I. and de Craen, A. J. M. and van Buchem, M. A. and Wardlaw, J. M.}, title = {{Cerebral blood flow in small vessel disease: A systematic review and meta-analysis}}, journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year = {2016}, doi = {10.1177/0271678x16662891}, pmid = {27496552}, url = {https://doi.org/10.1177/0271678x16662891} } @article{lane2019-31444142, author = {Lane, C. A. and Barnes, J. and Nicholas, J. M. and Sudre, C. H. and Cash, D. M. and Parker, T. D. and Malone, I. B. and Lu, K. and others}, title = {{Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study}}, journal = {The Lancet. Neurology}, year = {2019}, doi = {10.1016/s1474-4422(19)30228-5}, pmid = {31444142}, url = {https://doi.org/10.1016/s1474-4422(19)30228-5} } @article{gardner2018-29669907, author = {Gardner, R. C. and Byers, A. L. and Barnes, D. E. and Li, Y. and Boscardin, J. and Yaffe, K.}, title = {{Mild TBI and risk of Parkinson disease: A Chronic Effects of Neurotrauma Consortium Study}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005522}, pmid = {29669907}, url = {https://doi.org/10.1212/wnl.0000000000005522} } @article{armstrong2020-32517579, author = {Armstrong, N. J. and Mather, K. A. and Sargurupremraj, M. and Knol, M. J. and Malik, R. and Satizabal, C. L. and Yanek, L. R. and Wen, W. and others}, title = {{Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities}}, journal = {Stroke}, year = {2020}, doi = {10.1161/strokeaha.119.027544}, pmid = {32517579}, url = {https://doi.org/10.1161/strokeaha.119.027544} } @article{veldsman2020-32895386, author = {Veldsman, M. and Tai, X. Y. and Nichols, T. and Smith, S. and Peixoto, J. and Manohar, S. and Husain, M.}, title = {{Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing}}, journal = {Nature communications}, year = {2020}, doi = {10.1038/s41467-020-18201-5}, pmid = {32895386}, url = {https://doi.org/10.1038/s41467-020-18201-5} } @article{morato2023-37012306, author = {Morató, X. and Marquié, M. and Tartari, J. P. and Lafuente, A. and Abdelnour, C. and Alegret, M. and Jofresa, S. and Buendía, M. and others}, title = {{A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress}}, journal = {Scientific reports}, year = {2023}, doi = {10.1038/s41598-023-32515-6}, pmid = {37012306}, url = {https://doi.org/10.1038/s41598-023-32515-6} } @article{sargurupremraj2020-33293549, author = {Sargurupremraj, M. and Suzuki, H. and Jian, X. and Sarnowski, C. and Evans, T. E. and Bis, J. C. and Eiriksdottir, G. and Sakaue, S. and others}, title = {{Cerebral small vessel disease genomics and its implications across the lifespan}}, journal = {Nature communications}, year = {2020}, doi = {10.1038/s41467-020-19111-2}, pmid = {33293549}, url = {https://doi.org/10.1038/s41467-020-19111-2} } @article{crane2016-27400367, author = {Crane, P. K. and Gibbons, L. E. and Dams-O'Connor, K. and Trittschuh, E. and Leverenz, J. B. and Keene, C. D. and Sonnen, J. and Montine, T. J. and others}, title = {{Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.1948}, pmid = {27400367}, url = {https://doi.org/10.1001/jamaneurol.2016.1948} } @article{zernecke2020-32673538, author = {Zernecke, A. and Winkels, H. and Cochain, C. and Williams, J. W. and Wolf, D. and Soehnlein, O. and Robbins, C. S. and Monaco, C. and others}, title = {{Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas}}, journal = {Circulation research}, year = {2020}, doi = {10.1161/circresaha.120.316903}, pmid = {32673538}, url = {https://doi.org/10.1161/circresaha.120.316903} } @article{boyle2015-26537052, author = {Boyle, P. A. and Yu, L. and Nag, S. and Leurgans, S. and Wilson, R. S. and Bennett, D. A. and Schneider, J. A.}, title = {{Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000002175}, pmid = {26537052}, url = {https://doi.org/10.1212/wnl.0000000000002175} } @article{johnson2013-23365092, author = {Johnson, V. E. and Stewart, J. E. and Begbie, F. D. and Trojanowski, J. Q. and Smith, D. H. and Stewart, W.}, title = {{Inflammation and white matter degeneration persist for years after a single traumatic brain injury}}, journal = {Brain : a journal of neurology}, year = {2013}, doi = {10.1093/brain/aws322}, pmid = {23365092}, url = {https://doi.org/10.1093/brain/aws322} } @article{verhaaren2015-25663218, author = {Verhaaren, B. F. and Debette, S. and Bis, J. C. and Smith, J. A. and Ikram, M. K. and Adams, H. H. and Beecham, A. H. and Rajan, K. B. and others}, title = {{Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI}}, journal = {Circulation. Cardiovascular genetics}, year = {2015}, doi = {10.1161/circgenetics.114.000858}, pmid = {25663218}, url = {https://doi.org/10.1161/circgenetics.114.000858} } @article{habes2023-37261829, author = {Habes, M. and Jacobson, A. M. and Braffett, B. H. and Rashid, T. and Ryan, C. M. and Shou, H. and Cui, Y. and Davatzikos, C. and others}, title = {{Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.16182}, pmid = {37261829}, url = {https://doi.org/10.1001/jamanetworkopen.2023.16182} } @article{clancy2021-33539776, author = {Clancy, U. and Gilmartin, D. and Jochems, A. C. C. and Knox, L. and Doubal, F. N. and Wardlaw, J. M.}, title = {{Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis}}, journal = {The lancet. Psychiatry}, year = {2021}, doi = {10.1016/s2215-0366(20)30431-4}, pmid = {33539776}, url = {https://doi.org/10.1016/s2215-0366(20)30431-4} } @article{arvanitakis2016-27312738, author = {Arvanitakis, Z. and Capuano, A. W. and Leurgans, S. E. and Bennett, D. A. and Schneider, J. A.}, title = {{Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2016}, doi = {10.1016/s1474-4422(16)30029-1}, pmid = {27312738}, url = {https://doi.org/10.1016/s1474-4422(16)30029-1} } @article{zietemann2018-30333158, author = {Zietemann, V. and Georgakis, M. K. and Dondaine, T. and Müller, C. and Mendyk, A. M. and Kopczak, A. and Hénon, H. and Bombois, S. and others}, title = {{Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006506}, pmid = {30333158}, url = {https://doi.org/10.1212/wnl.0000000000006506} } @article{jiang2024-39206795, author = {Jiang, Y. and Neal, J. and Sompol, P. and Yener, G. and Arakaki, X. and Norris, C. M. and Farina, F. R. and Ibanez, A. and others}, title = {{Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer's disease and related dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.14089}, pmid = {39206795}, url = {https://doi.org/10.1002/alz.14089} } @article{walker2017-29093073, author = {Walker, K. A. and Hoogeveen, R. C. and Folsom, A. R. and Ballantyne, C. M. and Knopman, D. S. and Windham, B. G. and Jack, C. R. and Gottesman, R. F.}, title = {{Midlife systemic inflammatory markers are associated with late-life brain volume: The ARIC study}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004688}, pmid = {29093073}, url = {https://doi.org/10.1212/wnl.0000000000004688} } @article{hughes2013-24132374, author = {Hughes, T. M. and Kuller, L. H. and Barinas-Mitchell, E. J. and Mackey, R. H. and McDade, E. M. and Klunk, W. E. and Aizenstein, H. J. and Cohen, A. D. and others}, title = {{Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults}}, journal = {Neurology}, year = {2013}, doi = {10.1212/01.wnl.0000435301.64776.37}, pmid = {24132374}, url = {https://doi.org/10.1212/01.wnl.0000435301.64776.37} } @article{arvanitakis2011-21387377, author = {Arvanitakis, Z. and Leurgans, S. E. and Wang, Z. and Wilson, R. S. and Bennett, D. A. and Schneider, J. A.}, title = {{Cerebral amyloid angiopathy pathology and cognitive domains in older persons}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22112}, pmid = {21387377}, url = {https://doi.org/10.1002/ana.22112} } @article{mcguinness2009-19821318, author = {McGuinness, B. and Todd, S. and Passmore, P. and Bullock, R.}, title = {{Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia}}, journal = {The Cochrane database of systematic reviews}, year = {2009}, doi = {10.1002/14651858.cd004034.pub3}, pmid = {19821318}, url = {https://doi.org/10.1002/14651858.cd004034.pub3} } @article{armstrong2019-31268512, author = {Armstrong, N. M. and An, Y. and Doshi, J. and Erus, G. and Ferrucci, L. and Davatzikos, C. and Deal, J. A. and Lin, F. R. and others}, title = {{Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss}}, journal = {JAMA otolaryngology-- head \& neck surgery}, year = {2019}, doi = {10.1001/jamaoto.2019.1610}, pmid = {31268512}, url = {https://doi.org/10.1001/jamaoto.2019.1610} } @article{henschel2020-32526386, author = {Henschel, L. and Conjeti, S. and Estrada, S. and Diers, K. and Fischl, B. and Reuter, M.}, title = {{FastSurfer - A fast and accurate deep learning based neuroimaging pipeline}}, journal = {NeuroImage}, year = {2020}, doi = {10.1016/j.neuroimage.2020.117012}, pmid = {32526386}, url = {https://doi.org/10.1016/j.neuroimage.2020.117012} } @article{spartano2019-31002329, author = {Spartano, N. L. and Davis-Plourde, K. L. and Himali, J. J. and Andersson, C. and Pase, M. P. and Maillard, P. and DeCarli, C. and Murabito, J. M. and others}, title = {{Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.2745}, pmid = {31002329}, url = {https://doi.org/10.1001/jamanetworkopen.2019.2745} } @article{lane2020-31682678, author = {Lane, C. A. and Barnes, J. and Nicholas, J. M. and Sudre, C. H. and Cash, D. M. and Malone, I. B. and Parker, T. D. and Keshavan, A. and others}, title = {{Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2019.3774}, pmid = {31682678}, url = {https://doi.org/10.1001/jamaneurol.2019.3774} } @article{jochems2025-39899790, author = {Jochems, Angela C.C. and Maniega, Susana Muñoz and Clancy, Úna and Arteaga, Carmen and García, Daniela Jaime and Chappell, Francesca M. and Hamilton, Olivia KL and Backhouse, Ellen V. and others}, title = {{Longitudinal Cognitive Changes in Cerebral Small Vessel Disease}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213323}, pmid = {39899790}, url = {https://doi.org/10.1212/wnl.0000000000213323} } @article{vermeer2003-12660385, author = {Vermeer, Sarah E. and Prins, Niels D. and den Heijer, Tom and Hofman, Albert and Koudstaal, Peter J. and Breteler, Monique M.B.}, title = {{Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline}}, journal = {New England Journal of Medicine}, year = {2003}, doi = {10.1056/nejmoa022066}, pmid = {12660385}, url = {https://doi.org/10.1056/nejmoa022066} } @article{elhusseini2023-37125534, author = {El Husseini, N. and Katzan, I. L. and Rost, N. S. and Blake, M. L. and Byun, E. and Pendlebury, S. T. and Aparicio, H. J. and Marquine, M. J. and others}, title = {{Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association/American Stroke Association}}, journal = {Stroke}, year = {2023}, doi = {10.1161/str.0000000000000430}, pmid = {37125534}, url = {https://doi.org/10.1161/str.0000000000000430} } @article{moran2013-23939539, author = {Moran, C. and Phan, T. G. and Chen, J. and Blizzard, L. and Beare, R. and Venn, A. and Münch, G. and Wood, A. G. and others}, title = {{Brain atrophy in type 2 diabetes: regional distribution and influence on cognition}}, journal = {Diabetes care}, year = {2013}, doi = {10.2337/dc13-0143}, pmid = {23939539}, url = {https://doi.org/10.2337/dc13-0143} } @article{lampe2019-30556596, author = {Lampe, L. and Zhang, R. and Beyer, F. and Huhn, S. and Kharabian Masouleh, S. and Preusser, S. and Bazin, P. L. and Schroeter, M. L. and others}, title = {{Visceral obesity relates to deep white matter hyperintensities via inflammation}}, journal = {Annals of neurology}, year = {2019}, doi = {10.1002/ana.25396}, pmid = {30556596}, url = {https://doi.org/10.1002/ana.25396} } @article{cho2022-36300346, author = {Cho, B. P. H. and Harshfield, E. L. and Al-Thani, M. and Tozer, D. J. and Bell, S. and Markus, H. S.}, title = {{Association of Vascular Risk Factors and Genetic Factors With Penetrance of Variants Causing Monogenic Stroke}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.3832}, pmid = {36300346}, url = {https://doi.org/10.1001/jamaneurol.2022.3832} } @article{brundel2012-22234334, author = {Brundel, M. and de Bresser, J. and van Dillen, J. J. and Kappelle, L. J. and Biessels, G. J.}, title = {{Cerebral microinfarcts: a systematic review of neuropathological studies}}, journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year = {2012}, doi = {10.1038/jcbfm.2011.200}, pmid = {22234334}, url = {https://doi.org/10.1038/jcbfm.2011.200} } @article{moran2019-30674592, author = {Moran, C. and Beare, R. and Wang, W. and Callisaya, M. and Srikanth, V.}, title = {{Type 2 diabetes mellitus, brain atrophy, and cognitive decline}}, journal = {Neurology}, year = {2019}, doi = {10.1212/wnl.0000000000006955}, pmid = {30674592}, url = {https://doi.org/10.1212/wnl.0000000000006955} } @article{geijselaers2015-25163604, author = {Geijselaers, S. L. C. and Sep, S. J. S. and Stehouwer, C. D. A. and Biessels, G. J.}, title = {{Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review}}, journal = {The lancet. Diabetes \& endocrinology}, year = {2015}, doi = {10.1016/s2213-8587(14)70148-2}, pmid = {25163604}, url = {https://doi.org/10.1016/s2213-8587(14)70148-2} } @article{mauschitz2018-29716786, author = {Mauschitz, M. M. and Bonnemaijer, P. W. M. and Diers, K. and Rauscher, F. G. and Elze, T. and Engel, C. and Loeffler, M. and Colijn, J. M. and others}, title = {{Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population}}, journal = {Ophthalmology}, year = {2018}, doi = {10.1016/j.ophtha.2018.03.026}, pmid = {29716786}, url = {https://doi.org/10.1016/j.ophtha.2018.03.026} } @article{uchida2025-40705997, author = {Uchida, Yuto and Onda, Kengo and Nishimaki, Kei and Kucharska‐Newton, Anna and Windham, Beverly Gwen and Wasserman, Bruce Alan and Oishi, Kenichi}, title = {{Longitudinal Changes in Brain Diffusion Characteristics Associated With Cognition and Vascular Risk Factors}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213867}, pmid = {40705997}, url = {https://doi.org/10.1212/wnl.0000000000213867} } @article{habes2018-30076276, author = {Habes, M. and Sotiras, A. and Erus, G. and Toledo, J. B. and Janowitz, D. and Wolk, D. A. and Shou, H. and Bryan, N. R. and others}, title = {{White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006116}, pmid = {30076276}, url = {https://doi.org/10.1212/wnl.0000000000006116} } @article{heaton2010-21135382, author = {Heaton, R. K. and Clifford, D. B. and Franklin, D. R. and Woods, S. P. and Ake, C. and Vaida, F. and Ellis, R. J. and Letendre, S. L. and others}, title = {{HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e318200d727}, pmid = {21135382}, url = {https://doi.org/10.1212/wnl.0b013e318200d727} } @article{schneider2017-28916531, author = {Schneider, A. L. C. and Selvin, E. and Sharrett, A. R. and Griswold, M. and Coresh, J. and Jack, C. R. and Knopman, D. and Mosley, T. and others}, title = {{Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)}}, journal = {Diabetes care}, year = {2017}, doi = {10.2337/dc17-1185}, pmid = {28916531}, url = {https://doi.org/10.2337/dc17-1185} } @article{rizvi2021-34609497, author = {Rizvi, B. and Lao, P. J. and Chesebro, A. G. and Dworkin, J. D. and Amarante, E. and Beato, J. M. and Gutierrez, J. and Zahodne, L. B. and others}, title = {{Association of Regional White Matter Hyperintensities With Longitudinal Alzheimer-Like Pattern of Neurodegeneration in Older Adults}}, journal = {JAMA network open}, year = {2021}, doi = {10.1001/jamanetworkopen.2021.25166}, pmid = {34609497}, url = {https://doi.org/10.1001/jamanetworkopen.2021.25166} } @article{habes2016-26912649, author = {Habes, M. and Erus, G. and Toledo, J. B. and Zhang, T. and Bryan, N. and Launer, L. J. and Rosseel, Y. and Janowitz, D. and others}, title = {{White matter hyperintensities and imaging patterns of brain ageing in the general population}}, journal = {Brain : a journal of neurology}, year = {2016}, doi = {10.1093/brain/aww008}, pmid = {26912649}, url = {https://doi.org/10.1093/brain/aww008} } @article{thambisetty2012-21824521, author = {Thambisetty, M. and An, Y. and Kinsey, A. and Koka, D. and Saleem, M. and Güntert, A. and Kraut, M. and Ferrucci, L. and others}, title = {{Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment}}, journal = {NeuroImage}, year = {2012}, doi = {10.1016/j.neuroimage.2011.07.056}, pmid = {21824521}, url = {https://doi.org/10.1016/j.neuroimage.2011.07.056} } @article{greenberg2025-40977537, author = {Greenberg, Steven Mark and Albert, Marylin S. and An, Hongyu and Arfanakis, Konstantinos and Evia, Arnold Moya and Caprihan, Arvind and Ford, Andria L. and Fornage, Myriam and others}, title = {{MarkVCID2 Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics}}, journal = {Annals of Neurology}, year = {2025}, doi = {10.1002/ana.78040}, pmid = {40977537}, url = {https://doi.org/10.1002/ana.78040} } @article{wardlaw2013-23867200, author = {Wardlaw, Joanna Marguerite and Smith, Eric Edward and Biessels, Geert Jan and Cordonnier, Charlotte and Fazekas, Franz and Frayne, Richard and Lindley, Richard I. and O'Brien, John Tiernan and others}, title = {{Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration}}, journal = {The Lancet Neurology}, year = {2013}, doi = {10.1016/s1474-4422(13)70124-8}, pmid = {23867200}, url = {https://doi.org/10.1016/s1474-4422(13)70124-8} } @article{duering2023-37236211, author = {Duering, Marco and Biessels, Geert Jan and Brodtmann, Amy G. and Chen, Christopher and Cordonnier, Charlotte and de Leeuw, Frank‐Erik and Debette, Stéphanie and Frayne, Richard and Jouvent, Éric and Rost, Natalia S. and ter Telgte, Annemieke and Salman, Rustam Al‐Shahi and Backes, Walter H. and Bae, Hee‐Joon and Brown, Rosalind and Chabriat, Hugues and De Luca, Alberto and DeCarli, Charles S and Dewenter, Anna and Doubal, Fergus and Ewers, Michael and Field, Thalia Shoshana and Ganesh, Aravind and Greenberg, Steven Mark and Helmer, Karl G. and Hilal, Saima and Jochems, Angela C.C. and Jokinen, Hanna and Kuijf, Hugo J. and Lam, Bonnie Y. K. and Lebenberg, Jessica and MacIntosh, Bradley John and Maillard, Pauline and Mok, Vincent and Pantoni, Leonardo and Rudilosso, Salvatore and Satizábal, Claudia Liliana and Schirmer, Markus D. and Schmidt, Reinhold and Smith, Colin and Staals, Julie and Thrippleton, Michael J. and van Veluw, Susanne J. and Vemuri, Prashanthi and Wang, Yilong and Werring, David John and Zedde, Marialuisa and Akinyemi, Rufus and Del Brutto, Óscar H. and Markus, Hugh Stephen and Zhu, Yi‐Cheng and Smith, Eric Edward and Dichgans, Martin and Wardlaw, Joanna Marguerite}, title = {{Neuroimaging standards for research into small vessel disease—advances since 2013}}, journal = {The Lancet Neurology}, year = {2023}, doi = {10.1016/s1474-4422(23)00131-x}, pmid = {37236211}, url = {https://doi.org/10.1016/s1474-4422(23)00131-x} } @article{ruttenjacobs2018-29752348, author = {Rutten-Jacobs, L. C. A. and Tozer, D. J. and Duering, M. and Malik, R. and Dichgans, M. and Markus, H. S. and Traylor, M.}, title = {{Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia}}, journal = {Stroke}, year = {2018}, doi = {10.1161/strokeaha.118.020811}, pmid = {29752348}, url = {https://doi.org/10.1161/strokeaha.118.020811} } @article{richard2010-20056923, author = {Richard, E. and Gouw, A. A. and Scheltens, P. and van Gool, W. A.}, title = {{Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of white matter lesions on MRI: the evaluation of vascular care in Alzheimer's disease (EVA) study}}, journal = {Stroke}, year = {2010}, doi = {10.1161/strokeaha.109.571281}, pmid = {20056923}, url = {https://doi.org/10.1161/strokeaha.109.571281} } @article{silbert2012-22843262, author = {Silbert, L. C. and Dodge, H. H. and Perkins, L. G. and Sherbakov, L. and Lahna, D. and Erten-Lyons, D. and Woltjer, R. and Shinto, L. and others}, title = {{Trajectory of white matter hyperintensity burden preceding mild cognitive impairment}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182661f2b}, pmid = {22843262}, url = {https://doi.org/10.1212/wnl.0b013e3182661f2b} } @article{marcus2011-21836088, author = {Marcus, J. and Gardener, H. and Rundek, T. and Elkind, M. S. and Sacco, R. L. and Decarli, C. and Wright, C. B.}, title = {{Baseline and longitudinal increases in diastolic blood pressure are associated with greater white matter hyperintensity volume: the northern Manhattan study}}, journal = {Stroke}, year = {2011}, doi = {10.1161/strokeaha.111.617571}, pmid = {21836088}, url = {https://doi.org/10.1161/strokeaha.111.617571} } @article{deleeuw2002-11912110, author = {de Leeuw, F. E. and de Groot, J. C. and Oudkerk, M. and Witteman, J. C. and Hofman, A. and van Gijn, J. and Breteler, M. M.}, title = {{Hypertension and cerebral white matter lesions in a prospective cohort study}}, journal = {Brain : a journal of neurology}, year = {2002}, doi = {10.1093/brain/awf077}, pmid = {11912110}, url = {https://doi.org/10.1093/brain/awf077} } @article{mitchell2011-22075523, author = {Mitchell, G. F. and van Buchem, M. A. and Sigurdsson, S. and Gotal, J. D. and Jonsdottir, M. K. and Ó, Kjartansson and Garcia, M. and Aspelund, T. and others}, title = {{Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study}}, journal = {Brain : a journal of neurology}, year = {2011}, doi = {10.1093/brain/awr253}, pmid = {22075523}, url = {https://doi.org/10.1093/brain/awr253} } @article{cox2019-30854560, author = {Cox, SR. and Lyall, D. M. and Ritchie, S. J. and Bastin, M. E. and Harris, M. A. and Buchanan, C. R. and Fawns-Ritchie, C. and Barbu, M. C. and others}, title = {{Associations between vascular risk factors and brain MRI indices in UK Biobank}}, journal = {European heart journal}, year = {2019}, doi = {10.1093/eurheartj/ehz100}, pmid = {30854560}, url = {https://doi.org/10.1093/eurheartj/ehz100} } @article{fotiadis2016-27180034, author = {Fotiadis, P. and van Rooden, S. and van der Grond, J. and Schultz, A. and Martinez-Ramirez, S. and Auriel, E. and Reijmer, Y. and van Opstal, A. M. and others}, title = {{Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study}}, journal = {The Lancet. Neurology}, year = {2016}, doi = {10.1016/s1474-4422(16)30030-8}, pmid = {27180034}, url = {https://doi.org/10.1016/s1474-4422(16)30030-8} } @article{chui2006-17192928, author = {Chui, H. C. and Zarow, C. and Mack, W. J. and Ellis, W. G. and Zheng, L. and Jagust, W. J. and Mungas, D. and Reed, B. R. and others}, title = {{Cognitive impact of subcortical vascular and Alzheimer's disease pathology}}, journal = {Annals of neurology}, year = {2006}, doi = {10.1002/ana.21009}, pmid = {17192928}, url = {https://doi.org/10.1002/ana.21009} } @article{vargassoria2023-36869375, author = {Vargas-Soria, M. and García-Alloza, M. and Corraliza-Gómez, M.}, title = {{Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies}}, journal = {Journal of neuroinflammation}, year = {2023}, doi = {10.1186/s12974-023-02740-x}, pmid = {36869375}, url = {https://doi.org/10.1186/s12974-023-02740-x} } @article{yoo2025-40204790, author = {Yoo, R. E. and Kim, J. H. and Moon, H. Y. and Park, J. Y. and Cheon, S. and Shin, H. S. and Han, D. and Kim, Y. and Park, S. H. and Choi, S. H.}, title = {{Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans}}, journal = {Nature Communications}, year = {2025}, doi = {10.1038/s41467-025-58726-1}, pmid = {40204790}, url = {https://doi.org/10.1038/s41467-025-58726-1} } @article{yates2014-24623839, author = {Yates, P. A. and Desmond, P. M. and Phal, P. M. and Steward, C. and Szoeke, C. and Salvado, O. and Ellis, K. A. and Martins, R. N. and others}, title = {{Incidence of cerebral microbleeds in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000285}, pmid = {24623839}, url = {https://doi.org/10.1212/wnl.0000000000000285} } @article{katz2021-33722990, author = {Katz, D. I. and Bernick, C. and Dodick, D. W. and Mez, J. and Mariani, M. L. and Adler, C. H. and Alosco, M. L. and Balcer, L. J. and others}, title = {{National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011850}, pmid = {33722990}, url = {https://doi.org/10.1212/wnl.0000000000011850} } @article{maillard2012-22815562, author = {Maillard, P. and Carmichael, O. and Fletcher, E. and Reed, B. and Mungas, D. and DeCarli, C.}, title = {{Coevolution of white matter hyperintensities and cognition in the elderly}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182617136}, pmid = {22815562}, url = {https://doi.org/10.1212/wnl.0b013e3182617136} } @article{greenberg2009-19161908, author = {Greenberg, S. M. and Vernooij, M. W. and Cordonnier, C. and Viswanathan, A. and Al-Shahi Salman, R. and Warach, S. and Launer, L. J. and Van Buchem, M. A. and others}, title = {{Cerebral microbleeds: a guide to detection and interpretation}}, journal = {The Lancet. Neurology}, year = {2009}, doi = {10.1016/s1474-4422(09)70013-4}, pmid = {19161908}, url = {https://doi.org/10.1016/s1474-4422(09)70013-4} } @article{akoudad2016-27271785, author = {Akoudad, S. and Wolters, F. J. and Viswanathan, A. and de Bruijn, R. F. and van der Lugt, A. and Hofman, A. and Koudstaal, P. J. and Ikram, M. A. and others}, title = {{Association of Cerebral Microbleeds With Cognitive Decline and Dementia}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.1017}, pmid = {27271785}, url = {https://doi.org/10.1001/jamaneurol.2016.1017} } @article{mandelli2016-27497488, author = {Mandelli, M. L. and Vilaplana, E. and Brown, J. A. and Hubbard, H. I. and Binney, R. J. and Attygalle, S. and Santos-Santos, M. A. and Miller, Z. A. and others}, title = {{Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia}}, journal = {Brain : a journal of neurology}, year = {2016}, doi = {10.1093/brain/aww195}, pmid = {27497488}, url = {https://doi.org/10.1093/brain/aww195} } @article{persyn2020-32358547, author = {Persyn, E. and Hanscombe, K. B. and Howson, J. M. M. and Lewis, C. M. and Traylor, M. and Markus, H. S.}, title = {{Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants}}, journal = {Nature communications}, year = {2020}, doi = {10.1038/s41467-020-15932-3}, pmid = {32358547}, url = {https://doi.org/10.1038/s41467-020-15932-3} } @article{dehavenon2023-37218590, author = {de Havenon, Adam and Parasuram, Nethra R. and Crawford, Anna L. and Mazurek, Mercy H. and Chavva, Isha R. and Yadlapalli, Vineetha and Iglesias, Juan Eugenio and Rosen, Matthew Scott and others}, title = {{Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging}}, journal = {Journal of the American Heart Association}, year = {2023}, doi = {10.1161/jaha.122.029242}, pmid = {37218590}, url = {https://doi.org/10.1161/jaha.122.029242} } @article{graurivera2020-31907066, author = {Grau-Rivera, O. and Operto, G. and Falcón, C. and Sánchez-Benavides, G. and Cacciaglia, R. and Brugulat-Serrat, A. and Gramunt, N. and Salvadó, G. and others}, title = {{Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults}}, journal = {Alzheimer's research \& therapy}, year = {2020}, doi = {10.1186/s13195-019-0547-3}, pmid = {31907066}, url = {https://doi.org/10.1186/s13195-019-0547-3} } @article{mckee2016-26667418, author = {McKee, A. C. and Cairns, N. J. and Dickson, D. W. and Folkerth, R. D. and Keene, C. D. and Litvan, I. and Perl, D. P. and Stein, T. D. and others}, title = {{The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-015-1515-z}, pmid = {26667418}, url = {https://doi.org/10.1007/s00401-015-1515-z} } @article{whitwell2010-21098403, author = {Whitwell, J. L. and Jack, C. R. and Boeve, B. F. and Parisi, J. E. and Ahlskog, J. E. and Drubach, D. A. and Senjem, M. L. and Knopman, D. S. and others}, title = {{Imaging correlates of pathology in corticobasal syndrome}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181feb2e8}, pmid = {21098403}, url = {https://doi.org/10.1212/wnl.0b013e3181feb2e8} } @article{debette2010-20167919, author = {Debette, S. and Beiser, A. and DeCarli, C. and Au, R. and Himali, J. J. and Kelly-Hayes, M. and Romero, JR. and Kase, C. S. and others}, title = {{Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study}}, journal = {Stroke}, year = {2010}, doi = {10.1161/strokeaha.109.570044}, pmid = {20167919}, url = {https://doi.org/10.1161/strokeaha.109.570044} } @article{chen2020-31901155, author = {Chen, H. F. and Huang, L. L. and Li, H. Y. and Qian, Y. and Yang, D. and Qing, Z. and Luo, C. M. and Li, M. C. and others}, title = {{Microstructural disruption of the right inferior fronto-occipital and inferior longitudinal fasciculus contributes to WMH-related cognitive impairment}}, journal = {CNS neuroscience \& therapeutics}, year = {2020}, doi = {10.1111/cns.13283}, pmid = {31901155}, url = {https://doi.org/10.1111/cns.13283} } @article{demeyere2016-26588918, author = {Demeyere, N. and Riddoch, M. J. and Slavkova, E. D. and Jones, K. and Reckless, I. and Mathieson, P. and Humphreys, G. W.}, title = {{Domain-specific versus generalized cognitive screening in acute stroke}}, journal = {Journal of neurology}, year = {2016}, doi = {10.1007/s00415-015-7964-4}, pmid = {26588918}, url = {https://doi.org/10.1007/s00415-015-7964-4} } @article{davis2015-25239680, author = {Davis, D. H. J. and Skelly, D. T. and Murray, C. and Hennessy, E. and Bowen, J. and Norton, S. and Brayne, C. and Rahkonen, T. and others}, title = {{Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2015}, doi = {10.1016/j.jagp.2014.08.005}, pmid = {25239680}, url = {https://doi.org/10.1016/j.jagp.2014.08.005} } @article{zhang2019-30939178, author = {Zhang, Y. S. and Zhou, N. and Knoll, B. M. and Samra, S. and Ward, M. R. and Weintraub, S. and Fawzi, A. A.}, title = {{Parafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer's Disease on optical coherence tomography angiography}}, journal = {PloS one}, year = {2019}, doi = {10.1371/journal.pone.0214685}, pmid = {30939178}, url = {https://doi.org/10.1371/journal.pone.0214685} } @article{dadar2022-34968832, author = {Dadar, M. and Manera, A. L. and Ducharme, S. and Collins, D. L.}, title = {{White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia}}, journal = {Neurobiology of aging}, year = {2022}, doi = {10.1016/j.neurobiolaging.2021.11.007}, pmid = {34968832}, url = {https://doi.org/10.1016/j.neurobiolaging.2021.11.007} } @article{pinheiro2025-40953349, author = {Pinheiro, Adlin and Ekenze, Oluchi Stella and Aparicio, Hugo Javier and Beiser, Alexa S. and DeCarli, Charles S and Demissie, Serkalem and Seshadri, Sudha S. and Romero, Jose Rafael}, title = {{Multimarker Cerebral Small Vessel Disease Score and Risk of Incident Dementia in the Framingham Heart Study}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000214113}, pmid = {40953349}, url = {https://doi.org/10.1212/wnl.0000000000214113} } @article{beyer2025-40189793, author = {Beyer, Frauke and Tsuchida, Ami and Soumaré, Aïcha and Rajula, Hema Sekhar Reddy and Mishra, Aniket and Crivello, Fabrice and Proust‐Lima, Cécile and Loeffler, Markus W. and others}, title = {{White matter hyperintensity spatial patterns: Risk factors and clinical correlates}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70053}, pmid = {40189793}, url = {https://doi.org/10.1002/alz.70053} } @article{sachdev2025-40955506, author = {Sachdev, Perminder Singh and Bentvelzen, Adam C. and Kochan, Nicole A. and Jiang, Jiyang and Hosoki, Satoshi and Koncz, Rebecca and Chander, Russell Jude and Saks, Danit and others}, title = {{Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.3242}, pmid = {40955506}, url = {https://doi.org/10.1001/jamaneurol.2025.3242} } @article{delrieu2020-33076983, author = {Delrieu, J. and Voisin, T. and Saint-Aubert, L. and Carrie, I. and Cantet, C. and Vellas, B. and Payoux, P. and Andrieu, S.}, title = {{The impact of a multi-domain intervention on cerebral glucose metabolism: analysis from the randomized ancillary FDG PET MAPT trial}}, journal = {Alzheimer's research \& therapy}, year = {2020}, doi = {10.1186/s13195-020-00683-6}, pmid = {33076983}, url = {https://doi.org/10.1186/s13195-020-00683-6} } @article{hohman2015-25751166, author = {Hohman, T. J. and Bell, S. P. and Jefferson, A. L. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{The role of vascular endothelial growth factor in neurodegeneration and cognitive decline: exploring interactions with biomarkers of Alzheimer disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2014.4761}, pmid = {25751166}, url = {https://doi.org/10.1001/jamaneurol.2014.4761} } @article{austin2022-35352569, author = {Austin, T. R. and Nasrallah, I. M. and Erus, G. and Desiderio, L. M. and Chen, L. Y. and Greenland, P. and Harding, B. N. and Hughes, T. M. and others}, title = {{Association of Brain Volumes and White Matter Injury With Race, Ethnicity, and Cardiovascular Risk Factors: The Multi-Ethnic Study of Atherosclerosis}}, journal = {Journal of the American Heart Association}, year = {2022}, doi = {10.1161/jaha.121.023159}, pmid = {35352569}, url = {https://doi.org/10.1161/jaha.121.023159} } @article{qiu2010-21172845, author = {Qiu, C. and Cotch, M. F. and Sigurdsson, S. and Jonsson, P. V. and Jonsdottir, M. K. and Sveinbjrnsdottir, S. and Eiriksdottir, G. and Klein, R. and others}, title = {{Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3182020349}, pmid = {21172845}, url = {https://doi.org/10.1212/wnl.0b013e3182020349} } @article{wardlaw2019-31097385, author = {Wardlaw, J. M. and Smith, C. and Dichgans, M.}, title = {{Small vessel disease: mechanisms and clinical implications}}, journal = {The Lancet. Neurology}, year = {2019}, doi = {10.1016/s1474-4422(19)30079-1}, pmid = {31097385}, url = {https://doi.org/10.1016/s1474-4422(19)30079-1} } @article{echouffotcheugui2018-30355700, author = {Echouffo-Tcheugui, J. B. and Conner, S. C. and Himali, J. J. and Maillard, P. and DeCarli, C. S. and Beiser, A. S. and Vasan, R. S. and Seshadri, S.}, title = {{Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006549}, pmid = {30355700}, url = {https://doi.org/10.1212/wnl.0000000000006549} } @article{pase2018-30232248, author = {Pase, M. P. and Davis-Plourde, K. and Himali, J. J. and Satizabal, C. L. and Aparicio, H. and Seshadri, S. and Beiser, A. S. and DeCarli, C.}, title = {{Vascular risk at younger ages most strongly associates with current and future brain volume}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006360}, pmid = {30232248}, url = {https://doi.org/10.1212/wnl.0000000000006360} } @article{keller2025-40423969, author = {Keller, Sarah A. and DeWitt, Amanda and Powell, W. Ryan and Ketchum, Frederick B. and Rissman, Robert A. and Bendlin, Barbara B. and Kind, Amy}, title = {{Adverse Social Exposome During the Life Course and Vascular Brain Injury}}, journal = {JAMA Network Open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.12289}, pmid = {40423969}, url = {https://doi.org/10.1001/jamanetworkopen.2025.12289} } @article{li2025-39823175, author = {Li, Jiahui and Ren, Yifei and Wang, Lidan and Zou, Xinrui and Ding, Xueran and Hou, Tingting and Zhang, Qinghua and Tang, Shi and others}, title = {{Estimated pulse wave velocity associated with cognitive phenotypes in a rural older population in China: A cohort study}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.14491}, pmid = {39823175}, url = {https://doi.org/10.1002/alz.14491} } @article{lakshminarayan2025-40906979, author = {Lakshminarayan, Kamakshi and Norby, Faye L. and Hong, Ching-Ping and Folsom, A.R. and Rosamond, Wayne D. and Gottesman, Rebecca F. and Koton, Silvia and Pike, James Russell and others}, title = {{Stroke, Cardiovascular Disease, and Dementia After Hospitalized TIA}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000214020}, pmid = {40906979}, url = {https://doi.org/10.1212/wnl.0000000000214020} } @article{masini2025-40052267, author = {Masini, Gabriele and Wang, Wendy and Ji, Yuekai and Eaton, Anne A. and Inciardi, Riccardo Maria and Soliman, Elsayed Z. and PASSMAN, ROD S. and Solomon, Scott David and others}, title = {{Markers of Left Atrial Myopathy: Prognostic Usefulness for Ischemic Stroke and Dementia in People in Sinus Rhythm}}, journal = {Stroke}, year = {2025}, doi = {10.1161/strokeaha.124.047747}, pmid = {40052267}, url = {https://doi.org/10.1161/strokeaha.124.047747} } @article{koton2026-41989779, author = {Koton, Silvia and Gross, Alden L. and Aparicio, Hugo Javier and Beiser, Alexa S. and Briceño, Emily M. and Coresh, Josef and Elkind, Mitchell S.V. and Giordani, Bruno and others}, title = {{Ischemic Stroke Incidence and Severity and Poststroke Cognitive Decline and Incident Dementia}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.8900}, pmid = {41989779}, url = {https://doi.org/10.1001/jamanetworkopen.2026.8900} } @article{qu2021-33517704, author = {Qu, Y. and Tan, C. C. and Shen, X. N. and Li, H. Q. and Cui, M. and Tan, L. and Dong, Q. and Yu, J. T. and others}, title = {{Association of Plasma Neurofilament Light With Small Vessel Disease Burden in Nondemented Elderly: A Longitudinal Study}}, journal = {Stroke}, year = {2021}, doi = {10.1161/strokeaha.120.030302}, pmid = {33517704}, url = {https://doi.org/10.1161/strokeaha.120.030302} } @article{hughes2018-29549223, author = {Hughes, T. M. and Wagenknecht, L. E. and Craft, S. and Mintz, A. and Heiss, G. and Palta, P. and Wong, D. and Zhou, Y. and others}, title = {{Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005259}, pmid = {29549223}, url = {https://doi.org/10.1212/wnl.0000000000005259} } @article{bruno2018-29632101, author = {Bruno, R. M. and Stea, F. and Sicari, R. and Ghiadoni, L. and Taddei, S. and Ungar, A. and Bonuccelli, U. and Tognoni, G. and others}, title = {{Vascular Function Is Improved After an Environmental Enrichment Program: The Train the Brain-Mind the Vessel Study}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2018}, doi = {10.1161/hypertensionaha.117.10066}, pmid = {29632101}, url = {https://doi.org/10.1161/hypertensionaha.117.10066} } @article{toledo2013-23842566, author = {Toledo, J. B. and Arnold, S. E. and Raible, K. and Brettschneider, J. and Xie, S. X. and Grossman, M. and Monsell, S. E. and Kukull, W. A. and others}, title = {{Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre}}, journal = {Brain : a journal of neurology}, year = {2013}, doi = {10.1093/brain/awt188}, pmid = {23842566}, url = {https://doi.org/10.1093/brain/awt188} } @article{zeydan2019-30326011, author = {Zeydan, B. and Tosakulwong, N. and Schwarz, C. G. and Senjem, M. L. and Gunter, J. L. and Reid, R. I. and Gazzuola Rocca, L. and Lesnick, T. G. and others}, title = {{Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2018.3057}, pmid = {30326011}, url = {https://doi.org/10.1001/jamaneurol.2018.3057} } @article{wardlaw2013-23602162, author = {Wardlaw, J. M. and Smith, C. and Dichgans, M.}, title = {{Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging}}, journal = {The Lancet. Neurology}, year = {2013}, doi = {10.1016/s1474-4422(13)70060-7}, pmid = {23602162}, url = {https://doi.org/10.1016/s1474-4422(13)70060-7} } @article{frey2019-30972001, author = {Frey, B. M. and Petersen, M. and Mayer, C. and Schulz, M. and Cheng, B. and Thomalla, G.}, title = {{Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies}}, journal = {Frontiers in neurology}, year = {2019}, doi = {10.3389/fneur.2019.00238}, pmid = {30972001}, url = {https://doi.org/10.3389/fneur.2019.00238} } @article{deleeuw2001-11118240, author = {de Leeuw, F. E. and de Groot, J. C. and Achten, E. and Oudkerk, M. and Ramos, L. M. and Heijboer, R. and Hofman, A. and Jolles, J. and others}, title = {{Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2001}, doi = {10.1136/jnnp.70.1.9}, pmid = {11118240}, url = {https://doi.org/10.1136/jnnp.70.1.9} } @article{vandijk2004-15466662, author = {van Dijk, E. J. and Breteler, M. M. and Schmidt, R. and Berger, K. and Nilsson, L. G. and Oudkerk, M. and Pajak, A. and Sans, S. and others}, title = {{The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2004}, doi = {10.1161/01.hyp.0000145857.98904.20}, pmid = {15466662}, url = {https://doi.org/10.1161/01.hyp.0000145857.98904.20} } @article{hainsworth2024-38044814, author = {Hainsworth, A. H. and Markus, H. S. and Schneider, J. A.}, title = {{Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2024}, doi = {10.1161/hypertensionaha.123.19943}, pmid = {38044814}, url = {https://doi.org/10.1161/hypertensionaha.123.19943} } @article{williams2025-40314392, author = {Williams, Jeremy R. and DeConne, Theodore M. and Pewowaruk, Ryan J. and Korcarz, Claudia E. and Tanley, Jordan E. and Carlsson, Cynthia M. and Heckbert, Susan R. and Habes, Mohamad and others}, title = {{Total and Structural Carotid Artery Stiffness Are Associated With Cognitive Decline and Structural Brain Abnormalities Related to Alzheimer Disease and Alzheimer Disease‐Related Dementias Pathology: The Multi‐Ethnic Study of Atherosclerosis}}, journal = {Journal of the American Heart Association}, year = {2025}, doi = {10.1161/jaha.124.039925}, pmid = {40314392}, url = {https://doi.org/10.1161/jaha.124.039925} } @article{levine2025-40062407, author = {Levine, Deborah A. and Whitney, Rachael T. and Ye, Wen and Briceño, Emily M. and Gross, Alden L. and Giordani, Bruno and Sussman, Jeremy B. and Lazar, Ronald M. and others}, title = {{Associations Between Stroke Type, Ischemic Stroke Subtypes, and Poststroke Cognitive Trajectories}}, journal = {Stroke}, year = {2025}, doi = {10.1161/strokeaha.124.047640}, pmid = {40062407}, url = {https://doi.org/10.1161/strokeaha.124.047640} } @article{hickman2013-24162652, author = {Hickman, Suzanne E. and Kingery, Nathan D. and Ohsumi, Toshiro K. and Borowsky, Mark L. and Wang, Li-chong and Means, Terry K. and El Khoury, Joseph B.}, title = {{The microglial sensome revealed by direct RNA sequencing}}, journal = {Nature Neuroscience}, year = {2013}, doi = {10.1038/nn.3554}, pmid = {24162652}, url = {https://doi.org/10.1038/nn.3554} } @article{schafer2012-22632727, author = {Schafer, Dorothy P. and Lehrman, Emily K. and Kautzman, Amanda G. and Koyama, Ryuta and Mardinly, Alan R. and Yamasaki, Ryo and Ransohoff, Richard M. and Greenberg, Michael E. and Barres, Ben A. and Stevens, Beth A.}, title = {{Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner}}, journal = {Neuron}, year = {2012}, doi = {10.1016/j.neuron.2012.03.026}, pmid = {22632727}, url = {https://doi.org/10.1016/j.neuron.2012.03.026} } @article{phuah2022-36123127, author = {Phuah, C. L. and Chen, Y. and Strain, J. F. and Yechoor, N. and Laurido-Soto, O. J. and Ances, B. M. and Lee, J. M. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Association of Data-Driven White Matter Hyperintensity Spatial Signatures With Distinct Cerebral Small Vessel Disease Etiologies}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201186}, pmid = {36123127}, url = {https://doi.org/10.1212/wnl.0000000000201186} } @article{ertenlyons2013-23935177, author = {Erten-Lyons, D. and Woltjer, R. and Kaye, J. and Mattek, N. and Dodge, H. H. and Green, S. and Tran, H. and Howieson, D. B. and others}, title = {{Neuropathologic basis of white matter hyperintensity accumulation with advanced age}}, journal = {Neurology}, year = {2013}, doi = {10.1212/wnl.0b013e3182a43e45}, pmid = {23935177}, url = {https://doi.org/10.1212/wnl.0b013e3182a43e45} } @article{mehta2021-33399511, author = {Mehta, R. I. and Carpenter, J. S. and Haut, M. W. and Ranjan, M. and Najib, U. and Lockman, P. and Wang, P. and others}, title = {{Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease}}, journal = {Radiology}, year = {2021}, doi = {10.1148/radiol.2021200643}, pmid = {33399511}, url = {https://doi.org/10.1148/radiol.2021200643} } @article{ferri2011-21402745, author = {Ferri, C. P. and Schoenborn, C. and Kalra, L. and Acosta, D. and Guerra, M. and Huang, Y. and Jacob, K. S. and Llibre Rodriguez, J. J. and others}, title = {{Prevalence of stroke and related burden among older people living in Latin America, India and China}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2011}, doi = {10.1136/jnnp.2010.234153}, pmid = {21402745}, url = {https://doi.org/10.1136/jnnp.2010.234153} } @article{ringstad2017-28969373, author = {Ringstad, G. and Vatnehol, S. A. S. and Eide, P. K.}, title = {{Glymphatic MRI in idiopathic normal pressure hydrocephalus}}, journal = {Brain : a journal of neurology}, year = {2017}, doi = {10.1093/brain/awx191}, pmid = {28969373}, url = {https://doi.org/10.1093/brain/awx191} } @article{deczkowska2018-29775591, author = {Deczkowska, A. and Keren-Shaul, H. and Weiner, A. and Colonna, M. and Schwartz, M. and Amit, I.}, title = {{Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration}}, journal = {Cell}, year = {2018}, doi = {10.1016/j.cell.2018.05.003}, pmid = {29775591}, url = {https://doi.org/10.1016/j.cell.2018.05.003} } @article{silvin2022-35931085, author = {Silvin, A. and Uderhardt, S. and Piot, C. and Da Mesquita, S. and Yang, K. and Geirsdottir, L. and Mulder, K. and Eyal, D. and others}, title = {{Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration}}, journal = {Immunity}, year = {2022}, doi = {10.1016/j.immuni.2022.07.004}, pmid = {35931085}, url = {https://doi.org/10.1016/j.immuni.2022.07.004} } @article{tagge2018-29360998, author = {Tagge, C. A. and Fisher, A. M. and Minaeva, O. V. and Gaudreau-Balderrama, A. and Moncaster, J. A. and Zhang, X. L. and Wojnarowicz, M. W. and Casey, N. and others}, title = {{Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model}}, journal = {Brain : a journal of neurology}, year = {2018}, doi = {10.1093/brain/awx350}, pmid = {29360998}, url = {https://doi.org/10.1093/brain/awx350} } @article{lyall2020-30903549, author = {Lyall, D. M. and Cox, SR. and Lyall, L. M. and Celis-Morales, C. and Cullen, B. and Mackay, D. F. and Ward, J. and Strawbridge, R. J. and others}, title = {{Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity}}, journal = {Brain imaging and behavior}, year = {2020}, doi = {10.1007/s11682-019-00069-9}, pmid = {30903549}, url = {https://doi.org/10.1007/s11682-019-00069-9} } @article{mccracken2022-36543768, author = {McCracken, C. and Raisi-Estabragh, Z. and Veldsman, M. and Raman, B. and Dennis, A. and Husain, M. and Nichols, T. E. and Petersen, S. E. and others}, title = {{Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants}}, journal = {Nature communications}, year = {2022}, doi = {10.1038/s41467-022-35321-2}, pmid = {36543768}, url = {https://doi.org/10.1038/s41467-022-35321-2} } @article{bowman2018-30120040, author = {Bowman, G. L. and Dayon, L. and Kirkland, R. and Wojcik, J. and Peyratout, G. and Severin, I. C. and Henry, H. and Oikonomidi, A. and others}, title = {{Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2018}, doi = {10.1016/j.jalz.2018.06.2857}, pmid = {30120040}, url = {https://doi.org/10.1016/j.jalz.2018.06.2857} } @article{mayerhofer2023-37360335, author = {Mayerhofer, Ernst and Zaba, Natalie O. and Parodi, Livia and Ganbold, Alena and Biffi, Alessandro and Rosand, Jonathan M. and Yechoor, Nirupama and Anderson, Christopher D.}, title = {{Disparities in brain health comorbidity management in intracerebral hemorrhage}}, journal = {Frontiers in Neurology}, year = {2023}, doi = {10.3389/fneur.2023.1194810}, pmid = {37360335}, url = {https://doi.org/10.3389/fneur.2023.1194810} } @article{parent2026-41916976, author = {Parent, Olivier and Alasmar, Zaki and Osborne, Sophia and Bussy, Aurélie and Costantino, Manuela and Fouquet, Jérémie P. and Quesada, Daniela and Bernier, Adeline and others}, title = {{Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions}}, journal = {Nature Communications}, year = {2026}, doi = {10.1038/s41467-026-70832-2}, pmid = {41916976}, url = {https://doi.org/10.1038/s41467-026-70832-2} } @article{zhang2014-25186741, author = {Zhang, Ye and Chen, Kenian and Sloan, Steven A. and Bennett, Mariko L. and Scholze, Anja R. and O’Keeffe, Sean and Phatnani, Hemali P. and Guarnieri, Paolo and Caneda, Christine and Ruderisch, Nadine and Deng, Shuyun and Liddelow, Shane A. and Zhang, Chaolin and Daneman, Richard and Maniatis, Tom and Barres, Ben A. and Wu, Jia Qian}, title = {{An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex}}, journal = {Journal of Neuroscience}, year = {2014}, doi = {10.1523/jneurosci.1860-14.2014}, pmid = {25186741}, url = {https://doi.org/10.1523/jneurosci.1860-14.2014} } @article{alber2019-31011621, author = {Alber, J. and Alladi, S. and Bae, H. J. and Barton, D. A. and Beckett, L. A. and Bell, J. M. and Berman, S. E. and Biessels, G. J. and others}, title = {{White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2019}, doi = {10.1016/j.trci.2019.02.001}, pmid = {31011621}, url = {https://doi.org/10.1016/j.trci.2019.02.001} } @article{voevodskaya2014-25339897, author = {Voevodskaya, O. and Simmons, A. and Nordenskjöld, R. and Kullberg, J. and Ahlström, H. and Lind, L. and Wahlund, L. O. and Larsson, E. M. and others}, title = {{The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease}}, journal = {Frontiers in aging neuroscience}, year = {2014}, doi = {10.3389/fnagi.2014.00264}, pmid = {25339897}, url = {https://doi.org/10.3389/fnagi.2014.00264} } @article{tullberg2004-15277616, author = {Tullberg, M. and Fletcher, E. and DeCarli, C. and Mungas, D. and Reed, B. R. and Harvey, D. J. and Weiner, M. W. and Chui, H. C. and others}, title = {{White matter lesions impair frontal lobe function regardless of their location}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000130530.55104.b5}, pmid = {15277616}, url = {https://doi.org/10.1212/01.wnl.0000130530.55104.b5} } @article{park2013-23495089, author = {Park, J. H. and Seo, S. W. and Kim, C. and Kim, G. H. and Noh, H. J. and Kim, S. T. and Kwak, K. C. and Yoon, U. and others}, title = {{Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment}}, journal = {Annals of neurology}, year = {2013}, doi = {10.1002/ana.23845}, pmid = {23495089}, url = {https://doi.org/10.1002/ana.23845} } @article{deramecourt2012-22377814, author = {Deramecourt, V. and Slade, J. Y. and Oakley, A. E. and Perry, R. H. and Ince, P. G. and Maurage, C. A. and Kalaria, R. N.}, title = {{Staging and natural history of cerebrovascular pathology in dementia}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e31824e8e7f}, pmid = {22377814}, url = {https://doi.org/10.1212/wnl.0b013e31824e8e7f} } @article{brickman2008-18695055, author = {Brickman, A. M. and Schupf, N. and Manly, J. J. and Luchsinger, J. A. and Andrews, H. and Tang, M. X. and Reitz, C. and Small, S. A. and others}, title = {{Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan}}, journal = {Archives of neurology}, year = {2008}, doi = {10.1001/archneur.65.8.1053}, pmid = {18695055}, url = {https://doi.org/10.1001/archneur.65.8.1053} } @article{smith2015-25428654, author = {Smith, E. E. and O'Donnell, M. and Dagenais, G. and Lear, S. A. and Wielgosz, A. and Sharma, M. and Poirier, P. and Stotts, G. and others}, title = {{Early cerebral small vessel disease and brain volume, cognition, and gait}}, journal = {Annals of neurology}, year = {2015}, doi = {10.1002/ana.24320}, pmid = {25428654}, url = {https://doi.org/10.1002/ana.24320} } @article{cannistraro2019-31142635, author = {Cannistraro, R. J. and Badi, M. and Eidelman, B. H. and Dickson, D. W. and Middlebrooks, E. H. and Meschia, J. F.}, title = {{CNS small vessel disease: A clinical review}}, journal = {Neurology}, year = {2019}, doi = {10.1212/wnl.0000000000007654}, pmid = {31142635}, url = {https://doi.org/10.1212/wnl.0000000000007654} } @article{vansloten2020-32135131, author = {van Sloten, T. T. and Sedaghat, S. and Carnethon, M. R. and Launer, L. J. and Stehouwer, C. D. A.}, title = {{Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression}}, journal = {The lancet. Diabetes \& endocrinology}, year = {2020}, doi = {10.1016/s2213-8587(19)30405-x}, pmid = {32135131}, url = {https://doi.org/10.1016/s2213-8587(19)30405-x} } @article{weinstein2015-25948725, author = {Weinstein, G. and Maillard, P. and Himali, J. J. and Beiser, A. S. and Au, R. and Wolf, P. A. and Seshadri, S. and DeCarli, C.}, title = {{Glucose indices are associated with cognitive and structural brain measures in young adults}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001655}, pmid = {25948725}, url = {https://doi.org/10.1212/wnl.0000000000001655} } @article{ikram2008-18323497, author = {Ikram, M. A. and van Oijen, M. and de Jong, F. J. and Kors, J. A. and Koudstaal, P. J. and Hofman, A. and Witteman, J. C. and Breteler, M. M.}, title = {{Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease}}, journal = {Stroke}, year = {2008}, doi = {10.1161/strokeaha.107.501106}, pmid = {18323497}, url = {https://doi.org/10.1161/strokeaha.107.501106} } @article{sun2025-39818967, author = {Sun, Zihan and Harshfield, Eric L. and de Leeuw, Frank‐Erik and Burgess, Stephen and Butterworth, Adam S. and Riksen, Niels P. and Mallat, Ziad and Markus, Hugh Stephen}, title = {{Proteins Involved in Endothelial Function and Inflammation Are Implicated in Cerebral Small Vessel Disease}}, journal = {Stroke}, year = {2025}, doi = {10.1161/strokeaha.124.049079}, pmid = {39818967}, url = {https://doi.org/10.1161/strokeaha.124.049079} } @article{siddiquee2025-39896231, author = {Siddiquee, Ali Tanweer and Hwang, Yoon Ho and Kim, Soriul and Shin, Sung Jin and Lee, Ji Soo and Kang, June Christoph and Lee, Min‐Hee and Kim, Hyeon Jin and others}, title = {{Middle-age cerebral small vessel disease and cognitive function in later life: a population-based prospective cohort study}}, journal = {The Lancet Regional Health - Western Pacific}, year = {2025}, doi = {10.1016/j.lanwpc.2024.101284}, pmid = {39896231}, url = {https://doi.org/10.1016/j.lanwpc.2024.101284} } @article{morgan2025-40528792, author = {Morgan, Alasdair G. and Thrippleton, Michael J. and Stringer, Michael S. and Chappell, Francesca M. and Hernández, Maria del Carmen Valdés and Wiseman, Stewart J. and Ballerini, Lucia and Brown, Rosalind and others}, title = {{Arterial, Venous, and Cerebrospinal Fluid Flow and Pulsatility in Stroke-Related Cerebral Small Vessel Disease: A Longitudinal Analysis}}, journal = {Stroke}, year = {2025}, doi = {10.1161/strokeaha.124.049103}, pmid = {40528792}, url = {https://doi.org/10.1161/strokeaha.124.049103} } @article{mcalpine2021-33395100, author = {McAlpine, L. S. and Fesharaki-Zadeh, A. and Spudich, S.}, title = {{Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?}}, journal = {Current opinion in psychiatry}, year = {2021}, doi = {10.1097/yco.0000000000000688}, pmid = {33395100}, url = {https://doi.org/10.1097/yco.0000000000000688} } @article{iliff2012-22896675, author = {Iliff, Jeffrey J. and Wang, Minghuan and Liao, Yonghong and Plogg, Benjamin A. and Peng, Weiguo and Gundersen, Georg Andreas and Benveniste, Helene and Vates, George Edward and Deane, Rashid and Goldman, Steven A. and Nagelhus, Erlend Arnulf and Nedergaard, Maiken}, title = {{A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β}}, journal = {Science Translational Medicine}, year = {2012}, doi = {10.1126/scitranslmed.3003748}, pmid = {22896675}, url = {https://doi.org/10.1126/scitranslmed.3003748} } @article{fischl2000-10984517, author = {Fischl, Bruce R. and Dale, Anders Martin}, title = {{Measuring the thickness of the human cerebral cortex from magnetic resonance images}}, journal = {Proceedings of the National Academy of Sciences}, year = {2000}, doi = {10.1073/pnas.200033797}, pmid = {10984517}, url = {https://doi.org/10.1073/pnas.200033797} } @article{gorelick2011-21778438, author = {Gorelick, P. B. and Scuteri, A. and Black, S. E. and Decarli, C. and Greenberg, S. M. and Iadecola, C. and Launer, L. J. and Laurent, S. and others}, title = {{Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association}}, journal = {Stroke}, year = {2011}, doi = {10.1161/str.0b013e3182299496}, pmid = {21778438}, url = {https://doi.org/10.1161/str.0b013e3182299496} } @article{gavett2010-20587081, author = {Gavett, B. E. and Stern, R. A. and Cantu, R. C. and Nowinski, C. J. and McKee, A. C.}, title = {{Mild traumatic brain injury: a risk factor for neurodegeneration}}, journal = {Alzheimer's research \& therapy}, year = {2010}, doi = {10.1186/alzrt42}, pmid = {20587081}, url = {https://doi.org/10.1186/alzrt42} } @article{yoshita2006-17190943, author = {Yoshita, M. and Fletcher, E. and Harvey, D. and Ortega, M. and Martinez, O. and Mungas, D. M. and Reed, B. R. and DeCarli, C. S.}, title = {{Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000249119.95747.1f}, pmid = {17190943}, url = {https://doi.org/10.1212/01.wnl.0000249119.95747.1f} } @article{jefferson2007-17389308, author = {Jefferson, A. L. and Massaro, J. M. and Wolf, P. A. and Seshadri, S. and Au, R. and Vasan, R. S. and Larson, M. G. and Meigs, J. B. and others}, title = {{Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000257815.20548.df}, pmid = {17389308}, url = {https://doi.org/10.1212/01.wnl.0000257815.20548.df} } @article{chard2021-33437067, author = {Chard, D. T. and Alahmadi, A. A. S. and Audoin, B. and Charalambous, T. and Enzinger, C. and Hulst, H. E. and Rocca, M. A. and À, Rovira and others}, title = {{Mind the gap: from neurons to networks to outcomes in multiple sclerosis}}, journal = {Nature reviews. Neurology}, year = {2021}, doi = {10.1038/s41582-020-00439-8}, pmid = {33437067}, url = {https://doi.org/10.1038/s41582-020-00439-8} } @article{mcarthur2004-15534180, author = {McArthur, J. C. and McDermott, M. P. and McClernon, D. and St Hillaire, C. and Conant, K. and Marder, K. and Schifitto, G. and Selnes, O. A. and others}, title = {{Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy}}, journal = {Archives of neurology}, year = {2004}, doi = {10.1001/archneur.61.11.1687}, pmid = {15534180}, url = {https://doi.org/10.1001/archneur.61.11.1687} } @article{chew2025-39039178, author = {Chew, E. Y. and Burns, S. A. and Abraham, A. G. and Bakhoum, M. F. and Beckman, J. A. and Chui, T. Y. P. and Finger, R. P. and Frangi, A. F. and others}, title = {{Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop}}, journal = {Nature reviews. Cardiology}, year = {2025}, doi = {10.1038/s41569-024-01060-8}, pmid = {39039178}, url = {https://doi.org/10.1038/s41569-024-01060-8} } @article{brett2022-34364650, author = {Brett, B. L. and Gardner, R. C. and Godbout, J. and Dams-O'Connor, K. and Keene, C. D.}, title = {{Traumatic Brain Injury and Risk of Neurodegenerative Disorder}}, journal = {Biological psychiatry}, year = {2022}, doi = {10.1016/j.biopsych.2021.05.025}, pmid = {34364650}, url = {https://doi.org/10.1016/j.biopsych.2021.05.025} } @article{inoue2023-37434208, author = {Inoue, Y. and Shue, F. and Bu, G. and Kanekiyo, T.}, title = {{Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2023}, doi = {10.1186/s13024-023-00640-5}, pmid = {37434208}, url = {https://doi.org/10.1186/s13024-023-00640-5} } @article{safaiyan2021-33606969, author = {Safaiyan, S. and Besson-Girard, S. and Kaya, T. and Cantuti-Castelvetri, L. and Liu, L. and Ji, H. and Schifferer, M. and Gouna, G. and others}, title = {{White matter aging drives microglial diversity}}, journal = {Neuron}, year = {2021}, doi = {10.1016/j.neuron.2021.01.027}, pmid = {33606969}, url = {https://doi.org/10.1016/j.neuron.2021.01.027} } @article{pase2016-27073239, author = {Pase, M. P. and Beiser, A. and Enserro, D. and Xanthakis, V. and Aparicio, H. and Satizabal, C. L. and Himali, J. J. and Kase, C. S. and others}, title = {{Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia}}, journal = {Stroke}, year = {2016}, doi = {10.1161/strokeaha.115.012608}, pmid = {27073239}, url = {https://doi.org/10.1161/strokeaha.115.012608} } @article{cho2021-33712516, author = {Cho, B. P. H. and Nannoni, S. and Harshfield, E. L. and Tozer, D. and Gräf, S. and Bell, S. and Markus, H. S.}, title = {{NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2021}, doi = {10.1136/jnnp-2020-325838}, pmid = {33712516}, url = {https://doi.org/10.1136/jnnp-2020-325838} } @article{romero2022-36175148, author = {Romero, JR. and Pinheiro, A. and Aparicio, H. J. and DeCarli, C. S. and Demissie, S. and Seshadri, S.}, title = {{MRI-Visible Perivascular Spaces and Risk of Incident Dementia: The Framingham Heart Study}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201293}, pmid = {36175148}, url = {https://doi.org/10.1212/wnl.0000000000201293} } @article{guardia2025-40289686, author = {Guardia, Gemma Sole and Li, Hao and Willemse, Luc and Lebenberg, Jessica and Jouvent, Éric and Tuladhar, Anil M.}, title = {{Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70212}, pmid = {40289686}, url = {https://doi.org/10.1002/alz.70212} } @article{li2025-40464223, author = {Li, Yuna and Tian, Shan and Qiao, Yuan and Cong, Chaohua and Yang, Junting and Cao, Shanshan and Zhu, Xirui and Zhao, Lei and others}, title = {{Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury}}, journal = {Journal of Cachexia Sarcopenia and Muscle}, year = {2025}, doi = {10.1002/jcsm.13833}, pmid = {40464223}, url = {https://doi.org/10.1002/jcsm.13833} } @article{debette2010-20660506, author = {Debette, Stéphanie and Markus, Hugh Stephen}, title = {{The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis}}, journal = {BMJ}, year = {2010}, doi = {10.1136/bmj.c3666}, pmid = {20660506}, url = {https://doi.org/10.1136/bmj.c3666} } @article{asken2022-35481808, author = {Asken, B. M. and Tanner, J. A. and VandeVrede, L. and Casaletto, K. B. and Staffaroni, A. M. and Mundada, N. and Fonseca, C. and Iaccarino, L. and others}, title = {{Multi-Modal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinicopathological Case Series}}, journal = {Journal of neurotrauma}, year = {2022}, doi = {10.1089/neu.2022.0060}, pmid = {35481808}, url = {https://doi.org/10.1089/neu.2022.0060} } @article{smith2017-27980126, author = {Smith, E. E. and Saposnik, G. and Biessels, G. J. and Doubal, F. N. and Fornage, M. and Gorelick, P. B. and Greenberg, S. M. and Higashida, R. T. and others}, title = {{Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association}}, journal = {Stroke}, year = {2017}, doi = {10.1161/str.0000000000000116}, pmid = {27980126}, url = {https://doi.org/10.1161/str.0000000000000116} } @article{wardlaw2021-34414301, author = {Wardlaw, J. M. and Debette, S. and Jokinen, H. and De Leeuw, F. E. and Pantoni, L. and Chabriat, H. and Staals, J. and Doubal, F. and others}, title = {{ESO Guideline on covert cerebral small vessel disease}}, journal = {European stroke journal}, year = {2021}, doi = {10.1177/23969873211012132}, pmid = {34414301}, url = {https://doi.org/10.1177/23969873211012132} } @article{sachdev2014-24632990, author = {Sachdev, P. and Kalaria, R. and O'Brien, J. and Skoog, I. and Alladi, S. and Black, S. E. and Blacker, D. and Blazer, D. G. and others}, title = {{Diagnostic criteria for vascular cognitive disorders: a VASCOG statement}}, journal = {Alzheimer disease and associated disorders}, year = {2014}, doi = {10.1097/wad.0000000000000034}, pmid = {24632990}, url = {https://doi.org/10.1097/wad.0000000000000034} } @article{dichgans2017-28154105, author = {Dichgans, M. and Leys, D.}, title = {{Vascular Cognitive Impairment}}, journal = {Circulation research}, year = {2017}, doi = {10.1161/circresaha.116.308426}, pmid = {28154105}, url = {https://doi.org/10.1161/circresaha.116.308426} } @article{tsao2013-23935179, author = {Tsao, C. W. and Seshadri, S. and Beiser, A. S. and Westwood, A. J. and Decarli, C. and Au, R. and Himali, J. J. and Hamburg, N. M. and others}, title = {{Relations of arterial stiffness and endothelial function to brain aging in the community}}, journal = {Neurology}, year = {2013}, doi = {10.1212/wnl.0b013e3182a43e1c}, pmid = {23935179}, url = {https://doi.org/10.1212/wnl.0b013e3182a43e1c} } @article{kimberly2009-19349602, author = {Kimberly, W. T. and Gilson, A. and Rost, N. S. and Rosand, J. and Viswanathan, A. and Smith, E. E. and Greenberg, S. M.}, title = {{Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy}}, journal = {Neurology}, year = {2009}, doi = {10.1212/01.wnl.0000345666.83318.03}, pmid = {19349602}, url = {https://doi.org/10.1212/01.wnl.0000345666.83318.03} } @article{lee2014-24554306, author = {Lee, M. J. and Seo, S. W. and Na, D. L. and Kim, C. and Park, J. H. and Kim, G. H. and Kim, C. H. and Noh, Y. and others}, title = {{Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment}}, journal = {JAMA psychiatry}, year = {2014}, doi = {10.1001/jamapsychiatry.2013.4506}, pmid = {24554306}, url = {https://doi.org/10.1001/jamapsychiatry.2013.4506} } @article{pantoni2005-15459510, author = {Pantoni, L. and Basile, A. M. and Pracucci, G. and Asplund, K. and Bogousslavsky, J. and Chabriat, H. and Erkinjuntti, T. and Fazekas, F. and others}, title = {{Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology}}, journal = {Neuroepidemiology}, year = {2005}, doi = {10.1159/000081050}, pmid = {15459510}, url = {https://doi.org/10.1159/000081050} } @article{hahad2020-32560306, author = {Hahad, O. and Lelieveld, J. and Birklein, F. and Lieb, K. and Daiber, A. and Münzel, T.}, title = {{Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress}}, journal = {International journal of molecular sciences}, year = {2020}, doi = {10.3390/ijms21124306}, pmid = {32560306}, url = {https://doi.org/10.3390/ijms21124306} } @article{bashore2024-38385291, author = {Bashore, A. C. and Yan, H. and Xue, C. and Zhu, L. Y. and Kim, E. and Mawson, T. and Coronel, J. and Chung, A. and others}, title = {{High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis}}, journal = {Arteriosclerosis, thrombosis, and vascular biology}, year = {2024}, doi = {10.1161/atvbaha.123.320524}, pmid = {38385291}, url = {https://doi.org/10.1161/atvbaha.123.320524} } @article{dekkers2019-31012815, author = {Dekkers, I. A. and Jansen, P. R. and Lamb, H. J.}, title = {{Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank Study}}, journal = {Radiology}, year = {2019}, doi = {10.1148/radiol.2019181012}, pmid = {31012815}, url = {https://doi.org/10.1148/radiol.2019181012} } @article{navale2022-35451454, author = {Navale, S. S. and Mulugeta, A. and Zhou, A. and Llewellyn, D. J. and Hyppönen, E.}, title = {{Vitamin D and brain health: an observational and Mendelian randomization study}}, journal = {The American journal of clinical nutrition}, year = {2022}, doi = {10.1093/ajcn/nqac107}, pmid = {35451454}, url = {https://doi.org/10.1093/ajcn/nqac107} } @article{lee2022-35173313, author = {Lee, H. G. and Wheeler, M. A. and Quintana, F. J.}, title = {{Function and therapeutic value of astrocytes in neurological diseases}}, journal = {Nature reviews. Drug discovery}, year = {2022}, doi = {10.1038/s41573-022-00390-x}, pmid = {35173313}, url = {https://doi.org/10.1038/s41573-022-00390-x} } @article{ferruzzi2025-40097616, author = {Ferruzzi, Germano Junior and Campanile, Alfonso and Visco, Valeria and Loria, Francesco and Mone, Pasquale and Masarone, Daniele and Dattilo, Giuseppe and Agnelli, Graziella and others}, title = {{Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients}}, journal = {Hypertension Research}, year = {2025}, doi = {10.1038/s41440-025-02182-3}, pmid = {40097616}, url = {https://doi.org/10.1038/s41440-025-02182-3} } @article{kijpaisalratana2025-39939193, author = {Kijpaisalratana, Naruchorn and Phuah, Chia‐Ling and Ament, Zsuzsanna and Bhave, Varun M. and Guarniz, Ana‐Lucia Garcia and Duskin, Jonathan A. and Couch, Catharine A. and Irvin, Marguerite R. and others}, title = {{White matter hyperintensity severity modifies gut metabolite association with cognitive outcomes}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100086}, pmid = {39939193}, url = {https://doi.org/10.1016/j.tjpad.2025.100086} } @article{kalaria2016-26806700, author = {Kalaria, R. N. and Akinyemi, R. and Ihara, M.}, title = {{Stroke injury, cognitive impairment and vascular dementia}}, journal = {Biochimica et biophysica acta}, year = {2016}, doi = {10.1016/j.bbadis.2016.01.015}, pmid = {26806700}, url = {https://doi.org/10.1016/j.bbadis.2016.01.015} } @article{khatri2007-17962588, author = {Khatri, M. and Wright, C. B. and Nickolas, T. L. and Yoshita, M. and Paik, M. C. and Kranwinkel, G. and Sacco, R. L. and DeCarli, C.}, title = {{Chronic kidney disease is associated with white matter hyperintensity volume: the Northern Manhattan Study (NOMAS)}}, journal = {Stroke}, year = {2007}, doi = {10.1161/strokeaha.107.493593}, pmid = {17962588}, url = {https://doi.org/10.1161/strokeaha.107.493593} } @article{ogunmoroti2016-27792654, author = {Ogunmoroti, O. and Allen, N. B. and Cushman, M. and Michos, E. D. and Rundek, T. and Rana, J. S. and Blankstein, R. and Blumenthal, R. S. and others}, title = {{Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis}}, journal = {Journal of the American Heart Association}, year = {2016}, doi = {10.1161/jaha.116.003954}, pmid = {27792654}, url = {https://doi.org/10.1161/jaha.116.003954} } @article{gibbons2017-28050656, author = {Gibbons, C. H. and Schmidt, P. and Biaggioni, I. and Frazier-Mills, C. and Freeman, R. and Isaacson, S. and Karabin, B. and Kuritzky, L. and others}, title = {{The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension}}, journal = {Journal of neurology}, year = {2017}, doi = {10.1007/s00415-016-8375-x}, pmid = {28050656}, url = {https://doi.org/10.1007/s00415-016-8375-x} } @article{stam2007-17266107, author = {Stam, C. J. and Nolte, G. and Daffertshofer, A.}, title = {{Phase lag index: assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources}}, journal = {Human brain mapping}, year = {2007}, doi = {10.1002/hbm.20346}, pmid = {17266107}, url = {https://doi.org/10.1002/hbm.20346} } @article{wardlaw2020-32094487, author = {Wardlaw, J. M. and Benveniste, H. and Nedergaard, M. and Zlokovic, B. V. and Mestre, H. and Lee, H. and Doubal, F. N. and Brown, R. and others}, title = {{Perivascular spaces in the brain: anatomy, physiology and pathology}}, journal = {Nature reviews. Neurology}, year = {2020}, doi = {10.1038/s41582-020-0312-z}, pmid = {32094487}, url = {https://doi.org/10.1038/s41582-020-0312-z} } @article{denheijer2003-14595538, author = {den Heijer, T. and Vermeer, S. E. and van Dijk, E. J. and Prins, N. D. and Koudstaal, P. J. and Hofman, A. and Breteler, M. M.}, title = {{Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI}}, journal = {Diabetologia}, year = {2003}, doi = {10.1007/s00125-003-1235-0}, pmid = {14595538}, url = {https://doi.org/10.1007/s00125-003-1235-0} } @article{hu2010-20819999, author = {Hu, W. T. and Wang, Z. and Lee, V. M. and Trojanowski, J. Q. and Detre, J. A. and Grossman, M.}, title = {{Distinct cerebral perfusion patterns in FTLD and AD}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181f11e35}, pmid = {20819999}, url = {https://doi.org/10.1212/wnl.0b013e3181f11e35} } @article{brickman2009-19585953, author = {Brickman, A. M. and Muraskin, J. and Zimmerman, M. E.}, title = {{Structural neuroimaging in Altheimer's disease: do white matter hyperintensities matter?}}, journal = {Dialogues in clinical neuroscience}, year = {2009}, doi = {10.31887/dcns.2009.11.2/ambrickman}, pmid = {19585953}, url = {https://doi.org/10.31887/dcns.2009.11.2/ambrickman} } @article{polvikoski2010-21048201, author = {Polvikoski, T. M. and van Straaten, E. C. and Barkhof, F. and Sulkava, R. and Aronen, H. J. and Niinistö, L. and Oinas, M. and Scheltens, P. and others}, title = {{Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e318200d6f9}, pmid = {21048201}, url = {https://doi.org/10.1212/wnl.0b013e318200d6f9} } @article{marelli2016-27185022, author = {Marelli, A. and Miller, S. P. and Marino, B. S. and Jefferson, A. L. and Newburger, J. W.}, title = {{Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury}}, journal = {Circulation}, year = {2016}, doi = {10.1161/circulationaha.115.019881}, pmid = {27185022}, url = {https://doi.org/10.1161/circulationaha.115.019881} } @article{wright2005-15879345, author = {Wright, C. B. and Paik, M. C. and Brown, T. R. and Stabler, S. P. and Allen, R. H. and Sacco, R. L. and DeCarli, C.}, title = {{Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study}}, journal = {Stroke}, year = {2005}, doi = {10.1161/01.str.0000165923.02318.22}, pmid = {15879345}, url = {https://doi.org/10.1161/01.str.0000165923.02318.22} } @article{ringstad2018-29997300, author = {Ringstad, G. and Valnes, L. M. and Dale, A. M. and Pripp, A. H. and Vatnehol, S. S. and Emblem, K. E. and Mardal, K. A. and Eide, P. K.}, title = {{Brain-wide glymphatic enhancement and clearance in humans assessed with MRI}}, journal = {JCI insight}, year = {2018}, doi = {10.1172/jci.insight.121537}, pmid = {29997300}, url = {https://doi.org/10.1172/jci.insight.121537} } @article{touyz2018-29394331, author = {Touyz, R. M. and Alves-Lopes, R. and Rios, F. J. and Camargo, L. L. and Anagnostopoulou, A. and Arner, A. and Montezano, A. C.}, title = {{Vascular smooth muscle contraction in hypertension}}, journal = {Cardiovascular research}, year = {2018}, doi = {10.1093/cvr/cvy023}, pmid = {29394331}, url = {https://doi.org/10.1093/cvr/cvy023} } @article{iadecola2019-30920929, author = {Iadecola, C. and Gottesman, R. F.}, title = {{Neurovascular and Cognitive Dysfunction in Hypertension}}, journal = {Circulation research}, year = {2019}, doi = {10.1161/circresaha.118.313260}, pmid = {30920929}, url = {https://doi.org/10.1161/circresaha.118.313260} } @article{mielke2010-20813340, author = {Mielke, M. M. and Haughey, N. J. and Bandaru, V. V. and Schech, S. and Carrick, R. and Carlson, M. C. and Mori, S. and Miller, M. I. and others}, title = {{Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2010}, doi = {10.1016/j.jalz.2010.03.014}, pmid = {20813340}, url = {https://doi.org/10.1016/j.jalz.2010.03.014} } @article{kilroy2014-24038544, author = {Kilroy, E. and Apostolova, L. and Liu, C. and Yan, L. and Ringman, J. and Wang, D. J.}, title = {{Reliability of two-dimensional and three-dimensional pseudo-continuous arterial spin labeling perfusion MRI in elderly populations: comparison with 15O-water positron emission tomography}}, journal = {Journal of magnetic resonance imaging : JMRI}, year = {2014}, doi = {10.1002/jmri.24246}, pmid = {24038544}, url = {https://doi.org/10.1002/jmri.24246} } @article{medaglia2017-28779011, author = {Medaglia, J. D. and Huang, W. and Segarra, S. and Olm, C. and Gee, J. and Grossman, M. and Ribeiro, A. and McMillan, C. T. and others}, title = {{Brain network efficiency is influenced by the pathologic source of corticobasal syndrome}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004324}, pmid = {28779011}, url = {https://doi.org/10.1212/wnl.0000000000004324} } @article{ho2010-20570405, author = {Ho, A. J. and Raji, C. A. and Becker, J. T. and Lopez, O. L. and Kuller, L. H. and Hua, X. and Lee, S. and Hibar, D. and others}, title = {{Obesity is linked with lower brain volume in 700 AD and MCI patients}}, journal = {Neurobiology of aging}, year = {2010}, doi = {10.1016/j.neurobiolaging.2010.04.006}, pmid = {20570405}, url = {https://doi.org/10.1016/j.neurobiolaging.2010.04.006} } @article{haller2018-29558307, author = {Haller, S. and Vernooij, M. W. and Kuijer, J. P. A. and Larsson, E. M. and Jäger, H. R. and Barkhof, F.}, title = {{Cerebral Microbleeds: Imaging and Clinical Significance}}, journal = {Radiology}, year = {2018}, doi = {10.1148/radiol.2018170803}, pmid = {29558307}, url = {https://doi.org/10.1148/radiol.2018170803} } @article{guo2025-40230026, author = {Guo, Hai‐Hua and Gao, Pei‐Yang and Zhang, Wei and Fu, Yan and Chi, Hao‐Chen and Zhang, Zi‐Hao and Han, Shuang‐Ling and Han, Baolin and others}, title = {{Liver Diseases and Brain Disorders: Genetic Mechanisms and Biomarker Pathways in a Prospective Cohort Study From the UK Biobank}}, journal = {Journal of Neurochemistry}, year = {2025}, doi = {10.1111/jnc.70066}, pmid = {40230026}, url = {https://doi.org/10.1111/jnc.70066} } @article{bachmann2025-40781909, author = {Bachmann, Dario and Wybitul, Maha and Studer, Sandro T. and Saake, Antje and Rauen, Katrin and Buchmann, Andreas and von Rickenbach, Bettina and Gruber, Esmeralda and others}, title = {{Protective Effects of Socioeconomic Status and Lifestyle on Amyloid‐ and White Matter Hyperintensity ‐Related Longitudinal Brain Atrophy and Cognitive Decline}}, journal = {Annals of Neurology}, year = {2025}, doi = {10.1002/ana.70022}, pmid = {40781909}, url = {https://doi.org/10.1002/ana.70022} } @article{wahlund2001-11387493, author = {Wahlund, Lars‐Olof and Barkhof, Frederik and Fazekas, Franz and Bronge, Lena and Augustin, Michael and Sjögren, Magnus J.C. and Wallin, Anders and Adèr, H.J. and Leys, Didier and Pantoni, Leonardo and Pasquier, Florence and Erkinjuntti, Timo and Scheltens, Philip}, title = {{A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT}}, journal = {Stroke}, year = {2001}, doi = {10.1161/01.str.32.6.1318}, pmid = {11387493}, url = {https://doi.org/10.1161/01.str.32.6.1318} } @article{zlokovic2020-33030307, author = {Zlokovic, B. V. and Gottesman, R. F. and Bernstein, K. E. and Seshadri, S. and McKee, A. and Snyder, H. and Greenberg, S. M. and Yaffe, K. and others}, title = {{Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2020}, doi = {10.1002/alz.12157}, pmid = {33030307}, url = {https://doi.org/10.1002/alz.12157} } @article{kalaria2016-27062261, author = {Kalaria, R. N.}, title = {{Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-016-1571-z}, pmid = {27062261}, url = {https://doi.org/10.1007/s00401-016-1571-z} } @article{whitwell2008-18765650, author = {Whitwell, J. L. and Josephs, K. A. and Murray, M. E. and Kantarci, K. and Przybelski, S. A. and Weigand, S. D. and Vemuri, P. and Senjem, M. L. and others}, title = {{MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000324924.91351.7d}, pmid = {18765650}, url = {https://doi.org/10.1212/01.wnl.0000324924.91351.7d} } @article{bombois2008-18436882, author = {Bombois, S. and Debette, S. and Bruandet, A. and Delbeuck, X. and Delmaire, C. and Leys, D. and Pasquier, F.}, title = {{Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients}}, journal = {Stroke}, year = {2008}, doi = {10.1161/strokeaha.107.505206}, pmid = {18436882}, url = {https://doi.org/10.1161/strokeaha.107.505206} } @article{binnewijzend2016-26040647, author = {Binnewijzend, M. A. and Benedictus, M. R. and Kuijer, J. P. and van der Flier, W. M. and Teunissen, C. E. and Prins, N. D. and Wattjes, M. P. and van Berckel, B. N. and others}, title = {{Cerebral perfusion in the predementia stages of Alzheimer's disease}}, journal = {European radiology}, year = {2016}, doi = {10.1007/s00330-015-3834-9}, pmid = {26040647}, url = {https://doi.org/10.1007/s00330-015-3834-9} } @article{kim2017-28887373, author = {Kim, B. J. and Irwin, D. J. and Song, D. and Daniel, E. and Leveque, J. D. and Raquib, A. R. and Pan, W. and Ying, G. S. and others}, title = {{Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004500}, pmid = {28887373}, url = {https://doi.org/10.1212/wnl.0000000000004500} } @article{nunes2022-35130181, author = {Nunes, V. S. and da Silva Ferreira, G. and Quintão, E. C. R.}, title = {{Cholesterol metabolism in aging simultaneously altered in liver and nervous system}}, journal = {Aging}, year = {2022}, doi = {10.18632/aging.203880}, pmid = {35130181}, url = {https://doi.org/10.18632/aging.203880} } @article{marinescu2019-30844504, author = {Marinescu, R. V. and Eshaghi, A. and Lorenzi, M. and Young, A. L. and Oxtoby, N. P. and Garbarino, S. and Crutch, S. J. and Alexander, D. C. and others}, title = {{DIVE: A spatiotemporal progression model of brain pathology in neurodegenerative disorders}}, journal = {NeuroImage}, year = {2019}, doi = {10.1016/j.neuroimage.2019.02.053}, pmid = {30844504}, url = {https://doi.org/10.1016/j.neuroimage.2019.02.053} } @article{zhang2020-31903107, author = {Zhang, L. Y. and Pan, J. and Mamtilahun, M. and Zhu, Y. and Wang, L. and Venkatesh, A. and Shi, R. and Tu, X. and others}, title = {{Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion}}, journal = {Theranostics}, year = {2020}, doi = {10.7150/thno.35841}, pmid = {31903107}, url = {https://doi.org/10.7150/thno.35841} } @article{garcia2025-40275856, author = {García, Daniela Jaime and Clancy, Úna and Arteaga, Carmen and Hernández, Maria del Carmen Valdés and Chappell, Francesca M. and Jochems, Angela C.C. and Cheng, Yajun and Zhang, Junfang and others}, title = {{Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70152}, pmid = {40275856}, url = {https://doi.org/10.1002/alz.70152} } @article{johnson2025-40081846, author = {Johnson, Ian P. and Brigger, Hailey and Smith, Joel and Peasley, Emma and Champagne, Alison and Littig, Lauren and Lalwani, Dheeraj and Sze, Gordon K. and others}, title = {{Predicting White Matter Hyperintensity: Leveraging Portable MRI for Accessible Brain Health Screening}}, journal = {American Journal of Neuroradiology}, year = {2025}, doi = {10.3174/ajnr.a8734}, pmid = {40081846}, url = {https://doi.org/10.3174/ajnr.a8734} } @article{guardia2025-41216615, author = {Guardia, Gemma Sole and Li, Hao and Lebenberg, Jessica and Jacob, Mina Ayad and Uszynski, Ivy and Kessels, Roy P. C. and Norris, David Gordon and Poupon, Cyril and others}, title = {{Perivascular spaces, diffusion MRI markers and cognitive decline in cerebral small vessel disease}}, journal = {Cerebral Circulation - Cognition and Behavior}, year = {2025}, doi = {10.1016/j.cccb.2025.100405}, pmid = {41216615}, url = {https://doi.org/10.1016/j.cccb.2025.100405} } @article{huang2026-41988974, author = {Huang, Jiannan and Jali, Vidishaa and Robert, Caroline and Chen, Christopher and Gong, Lingli and Tan, Eugene S.J. and Richards, Mark and Ling, Lieng‐Hsi and others}, title = {{Association of Left Ventricular Function With Cerebral Small Vessel Disease and Cognition}}, journal = {Journal of the American Heart Association}, year = {2026}, doi = {10.1161/jaha.125.045947}, pmid = {41988974}, url = {https://doi.org/10.1161/jaha.125.045947} } @article{liao2026-42196255, author = {Liao, Y. and Zhao, L. and Zhu, Y. and Ye, S. and Huang, J. and Niu, Z. and Zhang, L. and Lei, N. and others}, title = {{Fluid Biomarkers of Cognitive Impairments Following Traumatic Brain Injury: A Systematic Review and Meta Analysis}}, journal = {International journal of molecular sciences}, year = {2026}, doi = {10.3390/ijms27104274}, pmid = {42196255}, url = {https://doi.org/10.3390/ijms27104274} } @article{jefferson2010-20679552, author = {Jefferson, A. L. and Himali, J. J. and Beiser, A. S. and Au, R. and Massaro, J. M. and Seshadri, S. and Gona, P. and Salton, C. J. and others}, title = {{Cardiac index is associated with brain aging: the Framingham Heart Study}}, journal = {Circulation}, year = {2010}, doi = {10.1161/circulationaha.109.905091}, pmid = {20679552}, url = {https://doi.org/10.1161/circulationaha.109.905091} } @article{maillard2013-22700749, author = {Maillard, P. and Carmichael, O. and Harvey, D. and Fletcher, E. and Reed, B. and Mungas, D. and DeCarli, C.}, title = {{FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities}}, journal = {AJNR. American journal of neuroradiology}, year = {2013}, doi = {10.3174/ajnr.a3146}, pmid = {22700749}, url = {https://doi.org/10.3174/ajnr.a3146} } @article{gefen2015-25632151, author = {Gefen, T. and Peterson, M. and Papastefan, S. T. and Martersteck, A. and Whitney, K. and Rademaker, A. and Bigio, E. H. and Weintraub, S. and others}, title = {{Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2015}, doi = {10.1523/jneurosci.2998-14.2015}, pmid = {25632151}, url = {https://doi.org/10.1523/jneurosci.2998-14.2015} } @article{vanderflier2005-16227537, author = {van der Flier, W. M. and van Straaten, E. C. and Barkhof, F. and Ferro, J. M. and Pantoni, L. and Basile, A. M. and Inzitari, D. and Erkinjuntti, T. and others}, title = {{Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2005}, doi = {10.1136/jnnp.2005.064998}, pmid = {16227537}, url = {https://doi.org/10.1136/jnnp.2005.064998} } @article{suri2016-27056984, author = {Suri, M. F. and Qiao, Y. and Ma, X. and Guallar, E. and Zhou, J. and Zhang, Y. and Liu, L. and Chu, H. and others}, title = {{Prevalence of Intracranial Atherosclerotic Stenosis Using High-Resolution Magnetic Resonance Angiography in the General Population: The Atherosclerosis Risk in Communities Study}}, journal = {Stroke}, year = {2016}, doi = {10.1161/strokeaha.115.011292}, pmid = {27056984}, url = {https://doi.org/10.1161/strokeaha.115.011292} } @article{anaclet2015-26524973, author = {Anaclet, C. and Pedersen, N. P. and Ferrari, L. L. and Venner, A. and Bass, C. E. and Arrigoni, E. and Fuller, P. M.}, title = {{Basal forebrain control of wakefulness and cortical rhythms}}, journal = {Nature communications}, year = {2015}, doi = {10.1038/ncomms9744}, pmid = {26524973}, url = {https://doi.org/10.1038/ncomms9744} } @article{zernecke2023-36190844, author = {Zernecke, A. and Erhard, F. and Weinberger, T. and Schulz, C. and Ley, K. and Saliba, A. E. and Cochain, C.}, title = {{Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis}}, journal = {Cardiovascular research}, year = {2023}, doi = {10.1093/cvr/cvac161}, pmid = {36190844}, url = {https://doi.org/10.1093/cvr/cvac161} } @article{vanveluw2015-25956990, author = {van Veluw, S. J. and Hilal, S. and Kuijf, H. J. and Ikram, M. K. and Xin, X. and Yeow, T. B. and Venketasubramanian, N. and Biessels, G. J. and others}, title = {{Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2014.12.010}, pmid = {25956990}, url = {https://doi.org/10.1016/j.jalz.2014.12.010} } @article{benedictus2017-27334014, author = {Benedictus, M. R. and Leeuwis, A. E. and Binnewijzend, M. A. and Kuijer, J. P. and Scheltens, P. and Barkhof, F. and van der Flier, W. M. and Prins, N. D.}, title = {{Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease}}, journal = {European radiology}, year = {2017}, doi = {10.1007/s00330-016-4450-z}, pmid = {27334014}, url = {https://doi.org/10.1007/s00330-016-4450-z} } @article{vasan2022-35168368, author = {Vasan, R. S. and Pan, S. and Xanthakis, V. and Beiser, A. and Larson, M. G. and Seshadri, S. and Mitchell, G. F.}, title = {{Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2022}, doi = {10.1161/hypertensionaha.121.18776}, pmid = {35168368}, url = {https://doi.org/10.1161/hypertensionaha.121.18776} } @article{ekdahl2003-14581618, author = {Ekdahl, C. T. and Claasen, J. H. and Bonde, S. and Kokaia, Z. and Lindvall, O.}, title = {{Inflammation is detrimental for neurogenesis in adult brain}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2003}, doi = {10.1073/pnas.2234031100}, pmid = {14581618}, url = {https://doi.org/10.1073/pnas.2234031100} } @article{kapoor2025-39787444, author = {Kapoor, Arunima and Dutt, Shubir and Engstrom, Allison C and Alitin, John Paul M and Lohman, Trevor and Sible, Isabel J. and Marshall, Anisa J. and Shenasa, Fatemah and others}, title = {{Association of Medial Temporal Lobe Cerebrovascular Reactivity and Memory Function in Older Adults With and Without Cognitive Impairment}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000210210}, pmid = {39787444}, url = {https://doi.org/10.1212/wnl.0000000000210210} } @article{mcevoy2025-40550886, author = {McEvoy, Claire T. and McCarthy, Geraldine M. and Townsend, Rebecca F. and Dolan, Catherine and Regan‐Moriarty, Joanne and Cardwell, Chris R. and McGuinness, Bernadette and Kennelly, Seán and others}, title = {{BRAIN-Diabetes: a randomised trial to test the feasibility of an adapted FINGER multidomain intervention in adults with type 2 diabetes living in rural border regions of Ireland}}, journal = {European Journal of Ageing}, year = {2025}, doi = {10.1007/s10433-025-00862-0}, pmid = {40550886}, url = {https://doi.org/10.1007/s10433-025-00862-0} } @article{kan2025-39761997, author = {Kan, Cheuk Ni and Coenen, Mirthe and Xu, Xin Yi and Hilal, Saima and Barkhof, Frederik and Benke, Thomas and Dal‐Bianco, Peter and DeCarli, Charles S and others}, title = {{Tract-specific white matter hyperintensities and neuropsychiatric syndromes: a multicentre memory clinic study}}, journal = {Journal of Neurology Neurosurgery \& Psychiatry}, year = {2025}, doi = {10.1136/jnnp-2024-334264}, pmid = {39761997}, url = {https://doi.org/10.1136/jnnp-2024-334264} } @article{caro2025-41266628, author = {Caro, Ilana and Western, Daniel and Namba, Shinichi and Sun, Na and Kawaguchi, Shuji and He, Yunye and Fujita, Masashi and Roshchupkin, Gennady V. and others}, title = {{Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease}}, journal = {Nature Aging}, year = {2025}, doi = {10.1038/s43587-025-01006-w}, pmid = {41266628}, url = {https://doi.org/10.1038/s43587-025-01006-w} } @article{zhou2026-41958244, author = {Zhou, C. and Han, Fei and Gao, Feng and Zhou, Lu and Yao, Ming and Ni, Jun and Cui, Li-Ying and Li, Ming-Li and others}, title = {{Cerebral small vessel disease burden relates to cognitive decline via impaired amyloid clearance in the general population}}, journal = {Journal of Cerebral Blood Flow \& Metabolism}, year = {2026}, doi = {10.1177/0271678x261437577}, pmid = {41958244}, url = {https://doi.org/10.1177/0271678x261437577} } @article{robb2025-40966613, author = {Robb, Catherine E. and Brodtmann, Amy G. and Woods, Robyn L. and Trevaks, Ruth E. and Ward, Stephanie Alison and Law, Meng and Orchard, Suzanne Gaye and Murray, Anne M. and others}, title = {{The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults}}, journal = {Age and Ageing}, year = {2025}, doi = {10.1093/ageing/afaf243}, pmid = {40966613}, url = {https://doi.org/10.1093/ageing/afaf243} } @article{kearneyschwartz2009-19246701, author = {Kearney-Schwartz, A. and Rossignol, P. and Bracard, S. and Felblinger, J. and Fay, R. and Boivin, J. M. and Lecompte, T. and Lacolley, P. and others}, title = {{Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints}}, journal = {Stroke}, year = {2009}, doi = {10.1161/strokeaha.108.532853}, pmid = {19246701}, url = {https://doi.org/10.1161/strokeaha.108.532853} } @article{birdsill2013-23687103, author = {Birdsill, A. C. and Carlsson, C. M. and Willette, A. A. and Okonkwo, O. C. and Johnson, S. C. and Xu, G. and Oh, J. M. and Gallagher, C. L. and others}, title = {{Low cerebral blood flow is associated with lower memory function in metabolic syndrome}}, journal = {Obesity (Silver Spring, Md.)}, year = {2013}, doi = {10.1002/oby.20170}, pmid = {23687103}, url = {https://doi.org/10.1002/oby.20170} } @article{pendlebury2012-22156700, author = {Pendlebury, S. T. and Mariz, J. and Bull, L. and Mehta, Z. and Rothwell, P. M.}, title = {{MoCA, ACE-R, and MMSE versus the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards Neuropsychological Battery after TIA and stroke}}, journal = {Stroke}, year = {2012}, doi = {10.1161/strokeaha.111.633586}, pmid = {22156700}, url = {https://doi.org/10.1161/strokeaha.111.633586} } @article{gurol2013-23424091, author = {Gurol, M. E. and Viswanathan, A. and Gidicsin, C. and Hedden, T. and Martinez-Ramirez, S. and Dumas, A. and Vashkevich, A. and Ayres, A. M. and others}, title = {{Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study}}, journal = {Annals of neurology}, year = {2013}, doi = {10.1002/ana.23830}, pmid = {23424091}, url = {https://doi.org/10.1002/ana.23830} } @article{smith2017-28754841, author = {Smith, R. and Schöll, M. and Widner, H. and van Westen, D. and Svenningsson, P. and Hägerström, D. and Ohlsson, T. and Jögi, J. and others}, title = {{In vivo retention of 18F-AV-1451 in corticobasal syndrome}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004264}, pmid = {28754841}, url = {https://doi.org/10.1212/wnl.0000000000004264} } @article{vanstraaten2008-18825439, author = {van Straaten, E. C. and Harvey, D. and Scheltens, P. and Barkhof, F. and Petersen, R. C. and Thal, L. J. and Jack, C. R. and DeCarli, C. and others}, title = {{Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia}}, journal = {Journal of neurology}, year = {2008}, doi = {10.1007/s00415-008-0874-y}, pmid = {18825439}, url = {https://doi.org/10.1007/s00415-008-0874-y} } @article{he2009-19901172, author = {He, J. and Farias, S. and Martinez, O. and Reed, B. and Mungas, D. and Decarli, C.}, title = {{Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypes}}, journal = {Archives of neurology}, year = {2009}, doi = {10.1001/archneurol.2009.252}, pmid = {19901172}, url = {https://doi.org/10.1001/archneurol.2009.252} } @article{meyer2017-28222517, author = {Meyer, M. L. and Palta, P. and Tanaka, H. and Deal, J. A. and Wright, J. and Knopman, D. S. and Griswold, M. E. and Mosley, T. H. and others}, title = {{Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia: The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS)}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-161041}, pmid = {28222517}, url = {https://doi.org/10.3233/jad-161041} } @article{dietschy2004-15254070, author = {Dietschy, J. M. and Turley, S. D.}, title = {{Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal}}, journal = {Journal of lipid research}, year = {2004}, doi = {10.1194/jlr.r400004-jlr200}, pmid = {15254070}, url = {https://doi.org/10.1194/jlr.r400004-jlr200} } @article{gardner2015-25748121, author = {Gardner, R. C. and Yaffe, K.}, title = {{Epidemiology of mild traumatic brain injury and neurodegenerative disease}}, journal = {Molecular and cellular neurosciences}, year = {2015}, doi = {10.1016/j.mcn.2015.03.001}, pmid = {25748121}, url = {https://doi.org/10.1016/j.mcn.2015.03.001} } @article{sundermann2014-24029388, author = {Sundermann, B. and Herr, D. and Schwindt, W. and Pfleiderer, B.}, title = {{Multivariate classification of blood oxygen level-dependent FMRI data with diagnostic intention: a clinical perspective}}, journal = {AJNR. American journal of neuroradiology}, year = {2014}, doi = {10.3174/ajnr.a3713}, pmid = {24029388}, url = {https://doi.org/10.3174/ajnr.a3713} } @article{reeves2020-31959516, author = {Reeves, B. C. and Karimy, J. K. and Kundishora, A. J. and Mestre, H. and Cerci, H. M. and Matouk, C. and Alper, S. L. and Lundgaard, I. and others}, title = {{Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus}}, journal = {Trends in molecular medicine}, year = {2020}, doi = {10.1016/j.molmed.2019.11.008}, pmid = {31959516}, url = {https://doi.org/10.1016/j.molmed.2019.11.008} } @article{faraco2016-27841763, author = {Faraco, G. and Sugiyama, Y. and Lane, D. and Garcia-Bonilla, L. and Chang, H. and Santisteban, M. M. and Racchumi, G. and Murphy, M. and others}, title = {{Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension}}, journal = {The Journal of clinical investigation}, year = {2016}, doi = {10.1172/jci86950}, pmid = {27841763}, url = {https://doi.org/10.1172/jci86950} } @article{yan2018-29930726, author = {Yan, T. and Wang, W. and Yang, L. and Chen, K. and Chen, R. and Han, Y.}, title = {{Rich club disturbances of the human connectome from subjective cognitive decline to Alzheimer's disease}}, journal = {Theranostics}, year = {2018}, doi = {10.7150/thno.23772}, pmid = {29930726}, url = {https://doi.org/10.7150/thno.23772} } @article{sturm2013-23716653, author = {Sturm, V. E. and Yokoyama, J. S. and Seeley, W. W. and Kramer, J. H. and Miller, B. L. and Rankin, K. P.}, title = {{Heightened emotional contagion in mild cognitive impairment and Alzheimer's disease is associated with temporal lobe degeneration}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2013}, doi = {10.1073/pnas.1301119110}, pmid = {23716653}, url = {https://doi.org/10.1073/pnas.1301119110} } @article{wang2011-21440071, author = {Wang, Y. and Song, Y. and Rajagopalan, P. and An, T. and Liu, K. and Chou, Y. Y. and Gutman, B. and Toga, A. W. and others}, title = {{Surface-based TBM boosts power to detect disease effects on the brain: an N=804 ADNI study}}, journal = {NeuroImage}, year = {2011}, doi = {10.1016/j.neuroimage.2011.03.040}, pmid = {21440071}, url = {https://doi.org/10.1016/j.neuroimage.2011.03.040} } @article{gray2020-32032968, author = {Gray, J. C. and Thompson, M. and Bachman, C. and Owens, M. M. and Murphy, M. and Palmer, R.}, title = {{Associations of cigarette smoking with gray and white matter in the UK Biobank}}, journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology}, year = {2020}, doi = {10.1038/s41386-020-0630-2}, pmid = {32032968}, url = {https://doi.org/10.1038/s41386-020-0630-2} } @article{schirge2025-40098158, author = {Schirge, P. M. and Perneczky, R. and Taoka, T. and Ruiz-Rizzo, A. L. and Ersoezlue, E. and Forbrig, R. and Guersel, S. and Kurz, C. and others}, title = {{Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-025-01707-9}, pmid = {40098158}, url = {https://doi.org/10.1186/s13195-025-01707-9} } @article{yarchoan2012-23204143, author = {Yarchoan, M. and Xie, S. X. and Kling, M. A. and Toledo, J. B. and Wolk, D. A. and Lee, E. B. and Van Deerlin, V. and Lee, V. M. and others}, title = {{Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias}}, journal = {Brain : a journal of neurology}, year = {2012}, doi = {10.1093/brain/aws271}, pmid = {23204143}, url = {https://doi.org/10.1093/brain/aws271} } @article{brandebura2023-36316501, author = {Brandebura, A. N. and Paumier, A. and Onur, T. S. and Allen, N. J.}, title = {{Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders}}, journal = {Nature reviews. Neuroscience}, year = {2023}, doi = {10.1038/s41583-022-00641-1}, pmid = {36316501}, url = {https://doi.org/10.1038/s41583-022-00641-1} } @article{propson2021-32990682, author = {Propson, N. E. and Roy, E. R. and Litvinchuk, A. and Köhl, J. and Zheng, H.}, title = {{Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging}}, journal = {The Journal of clinical investigation}, year = {2021}, doi = {10.1172/jci140966}, pmid = {32990682}, url = {https://doi.org/10.1172/jci140966} } @article{lam2024-db4b14cc, author = {Lam, Bonnie Y. K. and Hui, Vincent and Zheng, Huijing and Cai, Yuan and Griffanti, Ludovica and Suri, Sana and Ebmeier, Klaus P. and Nichols, Thomas E. and others}, title = {{Modes of covariation between vascular risk factors and cognition in cohorts with cultural and geographical variations}}, journal = {Cerebral Circulation - Cognition and Behavior}, year = {2024}, doi = {10.1016/j.cccb.2024.100296}, url = {https://doi.org/10.1016/j.cccb.2024.100296} } @article{ghiyamihoor2025-40241499, author = {Ghiyamihoor, Farshid and Peymani, Payam and Perron, Jarrad and Asemi‐Rad, Azam and Marzban, Mehdi and Mohite, Aashka and Ardila, Karen and Aljada, Bara and others}, title = {{Volumetric Changes in Cerebellar Transverse Zones: Age and Sex Effects in Health and Neurological Disorders}}, journal = {Human Brain Mapping}, year = {2025}, doi = {10.1002/hbm.70214}, pmid = {40241499}, url = {https://doi.org/10.1002/hbm.70214} } @article{cai2026-41479247, author = {Cai, Yuan and Mok, Vincent and Markus, Hugh Stephen}, title = {{Vascular dementia: World Stroke Organization fact sheet 2026}}, journal = {International Journal of Stroke}, year = {2026}, doi = {10.1177/17474930251404243}, pmid = {41479247}, url = {https://doi.org/10.1177/17474930251404243} } @article{abid2025-40425445, author = {Abid, Shehab Uddin Al and Calvin, Catherine M. and Qureshi, Danial and Veldsman, Michele and Kuźma, Elżbieta and Littlejohns, Thomas J.}, title = {{Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100208}, pmid = {40425445}, url = {https://doi.org/10.1016/j.tjpad.2025.100208} } @article{shiozaki2025-40589442, author = {Shiozaki, Kaori and Nagano, Ayano and Hanaoka, Mariko and Uchiyama, Yuki and Domen, Kazuhisa and Koyama, Tetsuo}, title = {{The Association Between Possible Sarcopenia and Delirium Onset in Older Patients With Acute Stroke}}, journal = {Cureus}, year = {2025}, doi = {10.7759/cureus.86993}, pmid = {40589442}, url = {https://doi.org/10.7759/cureus.86993} } @article{nasiri2025-41290806, author = {Nasiri, Hamide and Khosravi, Fatemeh and Saberian, Parsa and Kavian, Melika and Mozafar, Mehrdad and Torabi, Paria and Malekzadeh, Tannaz and Hadavi, Seyed Morteza and others}, title = {{White matter hyperintensity burden predicts domain-specific cognitive decline across the Alzheimer’s disease continuum}}, journal = {Scientific Reports}, year = {2025}, doi = {10.1038/s41598-025-25694-x}, pmid = {41290806}, url = {https://doi.org/10.1038/s41598-025-25694-x} } @article{brown2026-42257423, author = {Brown, Robin and Allan, Stuart McRae and Markus, Hugh Stephen}, title = {{The role of inflammation in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications}}, journal = {International Journal of Stroke}, year = {2026}, doi = {10.1177/17474930261461366}, pmid = {42257423}, url = {https://doi.org/10.1177/17474930261461366} } @article{siracusa2019-31611796, author = {Siracusa, R. and Fusco, R. and Cuzzocrea, S.}, title = {{Astrocytes: Role and Functions in Brain Pathologies}}, journal = {Frontiers in pharmacology}, year = {2019}, doi = {10.3389/fphar.2019.01114}, pmid = {31611796}, url = {https://doi.org/10.3389/fphar.2019.01114} } @article{rundek2022-34939171, author = {Rundek, T. and Tolea, M. and Ariko, T. and Fagerli, E. A. and Camargo, C. J.}, title = {{Vascular Cognitive Impairment (VCI)}}, journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics}, year = {2022}, doi = {10.1007/s13311-021-01170-y}, pmid = {34939171}, url = {https://doi.org/10.1007/s13311-021-01170-y} } @article{shi2016-28959468, author = {Shi, Y. and Wardlaw, J. M.}, title = {{Update on cerebral small vessel disease: a dynamic whole-brain disease}}, journal = {Stroke and vascular neurology}, year = {2016}, doi = {10.1136/svn-2016-000035}, pmid = {28959468}, url = {https://doi.org/10.1136/svn-2016-000035} } @article{musen2012-22664957, author = {Musen, G. and Jacobson, A. M. and Bolo, N. R. and Simonson, D. C. and Shenton, M. E. and McCartney, R. L. and Flores, V. L. and Hoogenboom, W. S.}, title = {{Resting-state brain functional connectivity is altered in type 2 diabetes}}, journal = {Diabetes}, year = {2012}, doi = {10.2337/db11-1669}, pmid = {22664957}, url = {https://doi.org/10.2337/db11-1669} } @article{graffradford2017-29018129, author = {Graff-Radford, J. and Simino, J. and Kantarci, K. and Mosley, T. H. and Griswold, M. E. and Windham, B. G. and Sharrett, A. R. and Albert, M. S. and others}, title = {{Neuroimaging Correlates of Cerebral Microbleeds: The ARIC Study (Atherosclerosis Risk in Communities)}}, journal = {Stroke}, year = {2017}, doi = {10.1161/strokeaha.117.018336}, pmid = {29018129}, url = {https://doi.org/10.1161/strokeaha.117.018336} } @article{vanveluw2016-26843561, author = {van Veluw, S. J. and Biessels, G. J. and Klijn, C. J. and Rozemuller, A. J.}, title = {{Heterogeneous histopathology of cortical microbleeds in cerebral amyloid angiopathy}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000002419}, pmid = {26843561}, url = {https://doi.org/10.1212/wnl.0000000000002419} } @article{chen2024-38252756, author = {Chen, L. H. and Spagnolo-Allende, A. and Yang, D. and Qiao, Y. and Gutierrez, J.}, title = {{Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease}}, journal = {Stroke}, year = {2024}, doi = {10.1161/strokeaha.123.043630}, pmid = {38252756}, url = {https://doi.org/10.1161/strokeaha.123.043630} } @article{diniz2015-25092249, author = {Diniz, B. S. and Sibille, E. and Ding, Y. and Tseng, G. and Aizenstein, H. J. and Lotrich, F. and Becker, J. T. and Lopez, O. L. and others}, title = {{Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression}}, journal = {Molecular psychiatry}, year = {2015}, doi = {10.1038/mp.2014.76}, pmid = {25092249}, url = {https://doi.org/10.1038/mp.2014.76} } @article{mielke2016-26908863, author = {Mielke, M. M. and Milic, N. M. and Weissgerber, T. L. and White, W. M. and Kantarci, K. and Mosley, T. H. and Windham, B. G. and Simpson, B. N. and others}, title = {{Impaired Cognition and Brain Atrophy Decades After Hypertensive Pregnancy Disorders}}, journal = {Circulation. Cardiovascular quality and outcomes}, year = {2016}, doi = {10.1161/circoutcomes.115.002461}, pmid = {26908863}, url = {https://doi.org/10.1161/circoutcomes.115.002461} } @article{hainsworth2017-28855392, author = {Hainsworth, A. H. and Minett, T. and Andoh, J. and Forster, G. and Bhide, I. and Barrick, T. R. and Elderfield, K. and Jeevahan, J. and others}, title = {{Neuropathology of White Matter Lesions, Blood-Brain Barrier Dysfunction, and Dementia}}, journal = {Stroke}, year = {2017}, doi = {10.1161/strokeaha.117.018101}, pmid = {28855392}, url = {https://doi.org/10.1161/strokeaha.117.018101} } @article{iadecola2008-18522829, author = {Iadecola, C. and Davisson, R. L.}, title = {{Hypertension and cerebrovascular dysfunction}}, journal = {Cell metabolism}, year = {2008}, doi = {10.1016/j.cmet.2008.03.010}, pmid = {18522829}, url = {https://doi.org/10.1016/j.cmet.2008.03.010} } @article{santisteban2023-36129176, author = {Santisteban, M. M. and Iadecola, C. and Carnevale, D.}, title = {{Hypertension, Neurovascular Dysfunction, and Cognitive Impairment}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2023}, doi = {10.1161/hypertensionaha.122.18085}, pmid = {36129176}, url = {https://doi.org/10.1161/hypertensionaha.122.18085} } @article{joutel2010-20071773, author = {Joutel, A. and Monet-Leprêtre, M. and Gosele, C. and Baron-Menguy, C. and Hammes, A. and Schmidt, S. and Lemaire-Carrette, B. and Domenga, V. and others}, title = {{Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease}}, journal = {The Journal of clinical investigation}, year = {2010}, doi = {10.1172/jci39733}, pmid = {20071773}, url = {https://doi.org/10.1172/jci39733} } @article{hong2024-38378607, author = {Hong, H. and Hong, L. and Luo, X. and Zeng, Q. and Li, K. and Wang, S. and Jiaerken, Y. and Zhang, R. and others}, title = {{The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer's disease continuum participants}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01407-w}, pmid = {38378607}, url = {https://doi.org/10.1186/s13195-024-01407-w} } @article{toth2017-27793855, author = {Toth, P. and Tarantini, S. and Csiszar, A. and Ungvari, Z.}, title = {{Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging}}, journal = {American journal of physiology. Heart and circulatory physiology}, year = {2017}, doi = {10.1152/ajpheart.00581.2016}, pmid = {27793855}, url = {https://doi.org/10.1152/ajpheart.00581.2016} } @article{tian2022-35682903, author = {Tian, Z. and Ji, X. and Liu, J.}, title = {{Neuroinflammation in Vascular Cognitive Impairment and Dementia: Current Evidence, Advances, and Prospects}}, journal = {International journal of molecular sciences}, year = {2022}, doi = {10.3390/ijms23116224}, pmid = {35682903}, url = {https://doi.org/10.3390/ijms23116224} } @article{konno2018-30429277, author = {Konno, T. and Kasanuki, K. and Ikeuchi, T. and Dickson, D. W. and Wszolek, Z. K.}, title = {{CSF1R-related leukoencephalopathy: A major player in primary microgliopathies}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000006642}, pmid = {30429277}, url = {https://doi.org/10.1212/wnl.0000000000006642} } @article{hammond2025-41434365, author = {Hammond, Angel and Navaratna, Ruvini and Moody, Jason F. and DeWitt, Amanda and Alosco, Michael Louis and Atri, Alireza and Bakulski, Kelly M. and Beach, Thomas G. and others}, title = {{Association of Neighborhood‐Level Disadvantage with Antemortem MRI Brain Volumes in a Multi‐site Brain Bank Donor Cohort}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70861_108929}, pmid = {41434365}, url = {https://doi.org/10.1002/alz70861_108929} } @article{wisch2025-39868891, author = {Wisch, Julie K. and Petersen, Kalen J. and Millar, Peter R and Abdelmoity, Omar and Babulal, Ganesh Muneshwar and Meeker, Karin L. and Braskie, Meredith N. and Yaffe, Kristine S. and others}, title = {{Cross‐Sectional Comparison of Structural MRI Markers of Impairment in a Diverse Cohort of Older Adults}}, journal = {Human Brain Mapping}, year = {2025}, doi = {10.1002/hbm.70133}, pmid = {39868891}, url = {https://doi.org/10.1002/hbm.70133} } @article{wang2025-40537069, author = {Wang, Shuyue and Zhang, Fan and Zeng, Qingze and Hong, Hui and Zhang, Yao and Xie, Linyun and Miao, Lin and Jiaerken, Yeerfan and others}, title = {{Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213666}, pmid = {40537069}, url = {https://doi.org/10.1212/wnl.0000000000213666} } @article{clancy2025-40237715, author = {Clancy, Úna and Cheng, Yajun and Jardine, Charlotte and Doubal, Fergus and MacLullich, Alasdair M. J. and Wardlaw, Joanna Marguerite}, title = {{Small vessel disease contributions to acute delirium: a pilot feasibility MRI study}}, journal = {Age and Ageing}, year = {2025}, doi = {10.1093/ageing/afaf099}, pmid = {40237715}, url = {https://doi.org/10.1093/ageing/afaf099} } @article{rotblatt2025-41104612, author = {Rotblatt, Lindsay J. and Edwards, Lauren and Erani, Fareshte R. and Terao, Caitlin Marie and Bangen, Katherine J. and Thomas, Kelsey R.}, title = {{Impact of regional white matter hyperintensity patterns on cognitive trajectories in NACC}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70764}, pmid = {41104612}, url = {https://doi.org/10.1002/alz.70764} } @article{roshan2023-36776051, author = {Roshan, S. A. and Elangovan, G. and Gunaseelan, D. and Jayachandran, S. K. and Kandasamy, M. and Anusuyadevi, M.}, title = {{Pathogenomic Signature and Aberrant Neurogenic Events in Experimental Cerebral Ischemic Stroke: A Neurotranscriptomic-Based Implication for Dementia}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2023}, doi = {10.3233/jad-220831}, pmid = {36776051}, url = {https://doi.org/10.3233/jad-220831} } @article{duong2021-33841127, author = {Duong, M. T. and Nasrallah, I. M. and Wolk, D. A. and Chang, C. C. Y. and Chang, T. Y.}, title = {{Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy}}, journal = {Frontiers in aging neuroscience}, year = {2021}, doi = {10.3389/fnagi.2021.647990}, pmid = {33841127}, url = {https://doi.org/10.3389/fnagi.2021.647990} } @article{nelson2016-26705676, author = {Nelson, A. R. and Sweeney, M. D. and Sagare, A. P. and Zlokovic, B. V.}, title = {{Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease}}, journal = {Biochimica et biophysica acta}, year = {2016}, doi = {10.1016/j.bbadis.2015.12.016}, pmid = {26705676}, url = {https://doi.org/10.1016/j.bbadis.2015.12.016} } @article{montenigro2014-25580160, author = {Montenigro, P. H. and Baugh, C. M. and Daneshvar, D. H. and Mez, J. and Budson, A. E. and Au, R. and Katz, D. I. and Cantu, R. C. and others}, title = {{Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome}}, journal = {Alzheimer's research \& therapy}, year = {2014}, doi = {10.1186/s13195-014-0068-z}, pmid = {25580160}, url = {https://doi.org/10.1186/s13195-014-0068-z} } @article{gavett2011-21074091, author = {Gavett, B. E. and Stern, R. A. and McKee, A. C.}, title = {{Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma}}, journal = {Clinics in sports medicine}, year = {2011}, doi = {10.1016/j.csm.2010.09.007}, pmid = {21074091}, url = {https://doi.org/10.1016/j.csm.2010.09.007} } @article{schmahmann2008-18990132, author = {Schmahmann, J. D. and Smith, E. E. and Eichler, F. S. and Filley, C. M.}, title = {{Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates}}, journal = {Annals of the New York Academy of Sciences}, year = {2008}, doi = {10.1196/annals.1444.017}, pmid = {18990132}, url = {https://doi.org/10.1196/annals.1444.017} } @article{vanderflier2005-16141425, author = {van der Flier, W. M. and van Straaten, E. C. and Barkhof, F. and Verdelho, A. and Madureira, S. and Pantoni, L. and Inzitari, D. and Erkinjuntti, T. and others}, title = {{Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study}}, journal = {Stroke}, year = {2005}, doi = {10.1161/01.str.0000179092.59909.42}, pmid = {16141425}, url = {https://doi.org/10.1161/01.str.0000179092.59909.42} } @article{aizenstein2016-27806704, author = {Aizenstein, H. J. and Baskys, A. and Boldrini, M. and Butters, M. A. and Diniz, B. S. and Jaiswal, M. K. and Jellinger, K. A. and Kruglov, L. S. and others}, title = {{Vascular depression consensus report - a critical update}}, journal = {BMC medicine}, year = {2016}, doi = {10.1186/s12916-016-0720-5}, pmid = {27806704}, url = {https://doi.org/10.1186/s12916-016-0720-5} } @article{chen2014-24658392, author = {Chen, Y. C. and Jiao, Y. and Cui, Y. and Shang, S. A. and Ding, J. and Feng, Y. and Song, W. and Ju, S. H. and others}, title = {{Aberrant brain functional connectivity related to insulin resistance in type 2 diabetes: a resting-state fMRI study}}, journal = {Diabetes care}, year = {2014}, doi = {10.2337/dc13-2127}, pmid = {24658392}, url = {https://doi.org/10.2337/dc13-2127} } @article{villeneuve2014-24907234, author = {Villeneuve, S. and Reed, B. R. and Madison, C. M. and Wirth, M. and Marchant, N. L. and Kriger, S. and Mack, W. J. and Sanossian, N. and others}, title = {{Vascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000550}, pmid = {24907234}, url = {https://doi.org/10.1212/wnl.0000000000000550} } @article{silbert2008-18606964, author = {Silbert, L. C. and Nelson, C. and Howieson, D. B. and Moore, M. M. and Kaye, J. A.}, title = {{Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000316799.86917.37}, pmid = {18606964}, url = {https://doi.org/10.1212/01.wnl.0000316799.86917.37} } @article{hay2015-26574669, author = {Hay, JR. and Johnson, V. E. and Young, A. M. and Smith, D. H. and Stewart, W.}, title = {{Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans}}, journal = {Journal of neuropathology and experimental neurology}, year = {2015}, doi = {10.1097/nen.0000000000000261}, pmid = {26574669}, url = {https://doi.org/10.1097/nen.0000000000000261} } @article{bos2012-22537801, author = {Bos, D. and Vernooij, M. W. and Elias-Smale, S. E. and Verhaaren, B. F. and Vrooman, H. A. and Hofman, A. and Niessen, W. J. and Witteman, J. C. and others}, title = {{Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2012}, doi = {10.1016/j.jalz.2012.01.008}, pmid = {22537801}, url = {https://doi.org/10.1016/j.jalz.2012.01.008} } @article{au2012-22471865, author = {Au, R. and Seshadri, S. and Knox, K. and Beiser, A. and Himali, J. J. and Cabral, H. J. and Auerbach, S. and Green, R. C. and others}, title = {{The Framingham Brain Donation Program: neuropathology along the cognitive continuum}}, journal = {Current Alzheimer research}, year = {2012}, doi = {10.2174/156720512801322609}, pmid = {22471865}, url = {https://doi.org/10.2174/156720512801322609} } @article{schwartz2019-31461676, author = {Schwartz, D. L. and Boespflug, E. L. and Lahna, D. L. and Pollock, J. and Roese, N. E. and Silbert, L. C.}, title = {{Autoidentification of perivascular spaces in white matter using clinical field strength T1 and FLAIR MR imaging}}, journal = {NeuroImage}, year = {2019}, doi = {10.1016/j.neuroimage.2019.116126}, pmid = {31461676}, url = {https://doi.org/10.1016/j.neuroimage.2019.116126} } @article{petrea2020-32755403, author = {Petrea, R. E. and O'Donnell, A. and Beiser, A. S. and Habes, M. and Aparicio, H. and DeCarli, C. and Seshadri, S. and Romero, JR.}, title = {{Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2020}, doi = {10.1161/hypertensionaha.120.15073}, pmid = {32755403}, url = {https://doi.org/10.1161/hypertensionaha.120.15073} } @article{morgantikossmann2019-30535946, author = {Morganti-Kossmann, M. C. and Semple, B. D. and Hellewell, S. C. and Bye, N. and Ziebell, J. M.}, title = {{The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments}}, journal = {Acta neuropathologica}, year = {2019}, doi = {10.1007/s00401-018-1944-6}, pmid = {30535946}, url = {https://doi.org/10.1007/s00401-018-1944-6} } @article{fu2026-42025299, author = {Fu, Jessie Fanglu and Juttukonda, Meher R. and Garimella, Arun H. and Mercaldo, Nathaniel David and Wey, Hsiao‐Ying and Salvatore, Andrew N. and Dickerson, Brad C. and Price, Julie C.}, title = {{Impact of Postlabeling Delay on Arterial Spin-Labeling MRI-Based Measures of Cerebral Blood Flow in a Simultaneous PET/MRI Study of Aging}}, journal = {American Journal of Neuroradiology}, year = {2026}, doi = {10.3174/ajnr.a9130}, pmid = {42025299}, url = {https://doi.org/10.3174/ajnr.a9130} } @article{fleischman2025-40588724, author = {Fleischman, Debra A. and Arfanakis, Konstantinos and Leurgans, Sue E. and Evia, Arnold Moya and Lamar, Melissa and Kapasi, Alifiya and Han, S. Duke and Poole, Victoria N. and others}, title = {{ARTS is associated with vascular risk factors, MCI, dementia, and stroke}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70430}, pmid = {40588724}, url = {https://doi.org/10.1002/alz.70430} } @article{lu2025-41073903, author = {Lu, Heyang and Li, Rui and Li, Jialin and Xu, Kelin and Jiang, Yanfeng and Wang, Yingzhe and Chen, Xingdong and Cui, Mei}, title = {{Associations of cholinergic white matter hyperintensity volume with cognitive decline and incident dementia in older adults: a cohort study}}, journal = {BMC Geriatrics}, year = {2025}, doi = {10.1186/s12877-025-06447-x}, pmid = {41073903}, url = {https://doi.org/10.1186/s12877-025-06447-x} } @article{jung2025-39916501, author = {Jung, Inha and Park, So Young and Lee, Da Young and Cho, Hyun Joo and Lee, Seung Ku and Seo, Ji A and Kim, Nan Hee and Shin, Chol and others}, title = {{Association of metabolic dysfunction‐associated fatty liver disease with white matter hyperintensity and cognitive decline: A longitudinal cohort study}}, journal = {Diabetes Obesity and Metabolism}, year = {2025}, doi = {10.1111/dom.16232}, pmid = {39916501}, url = {https://doi.org/10.1111/dom.16232} } @article{wezel2025-41426431, author = {Wezel, Denise and Parent, Olivier and Costantino, Manuela and Sifi, Lina and Pigeau, Grace and Gervais, Nicole J and McQuarrie, Ann and Maranzano, Josefina and others}, title = {{Investigating links between white matter hyperintensities and menopausal status using robust age-correction methods in UK Biobank}}, journal = {Brain Communications}, year = {2025}, doi = {10.1093/braincomms/fcaf475}, pmid = {41426431}, url = {https://doi.org/10.1093/braincomms/fcaf475} } @article{sharma2025-40249894, author = {Sharma, Richa and Hansen, Spencer L. and Merkler, Alexander Eliot and Lima, João A.C. and Longstreth, W.T.}, title = {{Left Ventricular Injury Detected by Cardiac MRI and Incident Ischemic Stroke and Dementia Risk}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213606}, pmid = {40249894}, url = {https://doi.org/10.1212/wnl.0000000000213606} } @article{gottesman2010-20723846, author = {Gottesman, R. F. and Hillis, A. E.}, title = {{Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke}}, journal = {The Lancet. Neurology}, year = {2010}, doi = {10.1016/s1474-4422(10)70164-2}, pmid = {20723846}, url = {https://doi.org/10.1016/s1474-4422(10)70164-2} } @article{vanveluw2013-23250109, author = {van Veluw, S. J. and Zwanenburg, J. J. and Engelen-Lee, J. and Spliet, W. G. and Hendrikse, J. and Luijten, P. R. and Biessels, G. J.}, title = {{In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI}}, journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year = {2013}, doi = {10.1038/jcbfm.2012.196}, pmid = {23250109}, url = {https://doi.org/10.1038/jcbfm.2012.196} } @article{bocti2005-16179569, author = {Bocti, C. and Swartz, R. H. and Gao, F. Q. and Sahlas, D. J. and Behl, P. and Black, S. E.}, title = {{A new visual rating scale to assess strategic white matter hyperintensities within cholinergic pathways in dementia}}, journal = {Stroke}, year = {2005}, doi = {10.1161/01.str.0000183615.07936.b6}, pmid = {16179569}, url = {https://doi.org/10.1161/01.str.0000183615.07936.b6} } @article{price2005-16087901, author = {Price, C. C. and Jefferson, A. L. and Merino, J. G. and Heilman, K. M. and Libon, D. J.}, title = {{Subcortical vascular dementia: integrating neuropsychological and neuroradiologic data}}, journal = {Neurology}, year = {2005}, doi = {10.1212/01.wnl.0000168877.06011.15}, pmid = {16087901}, url = {https://doi.org/10.1212/01.wnl.0000168877.06011.15} } @article{henneman2009-19109551, author = {Henneman, W. J. and Sluimer, J. D. and Cordonnier, C. and Baak, M. M. and Scheltens, P. and Barkhof, F. and van der Flier, W. M.}, title = {{MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population}}, journal = {Stroke}, year = {2009}, doi = {10.1161/strokeaha.108.516286}, pmid = {19109551}, url = {https://doi.org/10.1161/strokeaha.108.516286} } @article{bown2022-34810243, author = {Bown, C. W. and Carare, R. O. and Schrag, M. S. and Jefferson, A. L.}, title = {{Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000013077}, pmid = {34810243}, url = {https://doi.org/10.1212/wnl.0000000000013077} } @article{biessels2014-24931032, author = {Biessels, G. J. and Reijmer, Y. D.}, title = {{Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?}}, journal = {Diabetes}, year = {2014}, doi = {10.2337/db14-0348}, pmid = {24931032}, url = {https://doi.org/10.2337/db14-0348} } @article{elkind2020-32897811, author = {Elkind, M. S. V. and Boehme, A. K. and Smith, C. J. and Meisel, A. and Buckwalter, M. S.}, title = {{Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke}}, journal = {Stroke}, year = {2020}, doi = {10.1161/strokeaha.120.030429}, pmid = {32897811}, url = {https://doi.org/10.1161/strokeaha.120.030429} } @article{corriveau2016-27095366, author = {Corriveau, R. A. and Bosetti, F. and Emr, M. and Gladman, J. T. and Koenig, J. I. and Moy, C. S. and Pahigiannis, K. and Waddy, S. P. and others}, title = {{The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline}}, journal = {Cellular and molecular neurobiology}, year = {2016}, doi = {10.1007/s10571-016-0334-7}, pmid = {27095366}, url = {https://doi.org/10.1007/s10571-016-0334-7} } @article{yates2014-24432010, author = {Yates, P. A. and Villemagne, V. L. and Ellis, K. A. and Desmond, P. M. and Masters, C. L. and Rowe, C. C.}, title = {{Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations}}, journal = {Frontiers in neurology}, year = {2014}, doi = {10.3389/fneur.2013.00205}, pmid = {24432010}, url = {https://doi.org/10.3389/fneur.2013.00205} } @article{rosano2007-18043004, author = {Rosano, C. and Brach, J. and Studenski, S. and Longstreth, W. T. and Newman, A. B.}, title = {{Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults}}, journal = {Neuroepidemiology}, year = {2007}, doi = {10.1159/000111582}, pmid = {18043004}, url = {https://doi.org/10.1159/000111582} } @article{shang2021-34601962, author = {Shang, X. and Hill, E. and Zhu, Z. and Liu, J. and Ge, B. Z. and Wang, W. and He, M.}, title = {{The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2021}, doi = {10.1161/hypertensionaha.121.17608}, pmid = {34601962}, url = {https://doi.org/10.1161/hypertensionaha.121.17608} } @article{arbelornath2013-23818064, author = {Arbel-Ornath, M. and Hudry, E. and Eikermann-Haerter, K. and Hou, S. and Gregory, J. L. and Zhao, L. and Betensky, R. A. and Frosch, M. P. and others}, title = {{Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models}}, journal = {Acta neuropathologica}, year = {2013}, doi = {10.1007/s00401-013-1145-2}, pmid = {23818064}, url = {https://doi.org/10.1007/s00401-013-1145-2} } @article{chen2016-26935478, author = {Chen, W. W. and Zhang, X. and Huang, W. J.}, title = {{Role of neuroinflammation in neurodegenerative diseases (Review)}}, journal = {Molecular medicine reports}, year = {2016}, doi = {10.3892/mmr.2016.4948}, pmid = {26935478}, url = {https://doi.org/10.3892/mmr.2016.4948} } @article{tarantini2017-27845201, author = {Tarantini, S. and Tran, C. H. T. and Gordon, G. R. and Ungvari, Z. and Csiszar, A.}, title = {{Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline}}, journal = {Experimental gerontology}, year = {2017}, doi = {10.1016/j.exger.2016.11.004}, pmid = {27845201}, url = {https://doi.org/10.1016/j.exger.2016.11.004} } @article{skaper2018-29618972, author = {Skaper, S. D. and Facci, L. and Zusso, M. and Giusti, P.}, title = {{An Inflammation-Centric View of Neurological Disease: Beyond the Neuron}}, journal = {Frontiers in cellular neuroscience}, year = {2018}, doi = {10.3389/fncel.2018.00072}, pmid = {29618972}, url = {https://doi.org/10.3389/fncel.2018.00072} } @article{lloyd2019-31256193, author = {Lloyd, A. F. and Miron, V. E.}, title = {{The pro-remyelination properties of microglia in the central nervous system}}, journal = {Nature reviews. Neurology}, year = {2019}, doi = {10.1038/s41582-019-0184-2}, pmid = {31256193}, url = {https://doi.org/10.1038/s41582-019-0184-2} } @article{carnevale2012-22615109, author = {Carnevale, D. and Mascio, G. and D'Andrea, I. and Fardella, V. and Bell, R. D. and Branchi, I. and Pallante, F. and Zlokovic, B. and others}, title = {{Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature}}, journal = {Hypertension (Dallas, Tex. : 1979)}, year = {2012}, doi = {10.1161/hypertensionaha.112.195511}, pmid = {22615109}, url = {https://doi.org/10.1161/hypertensionaha.112.195511} } @article{mcmanus2017-28259169, author = {McManus, R. M. and Heneka, M. T.}, title = {{Role of neuroinflammation in neurodegeneration: new insights}}, journal = {Alzheimer's research \& therapy}, year = {2017}, doi = {10.1186/s13195-017-0241-2}, pmid = {28259169}, url = {https://doi.org/10.1186/s13195-017-0241-2} } @article{hase2018-29210074, author = {Hase, Y. and Horsburgh, K. and Ihara, M. and Kalaria, R. N.}, title = {{White matter degeneration in vascular and other ageing-related dementias}}, journal = {Journal of neurochemistry}, year = {2018}, doi = {10.1111/jnc.14271}, pmid = {29210074}, url = {https://doi.org/10.1111/jnc.14271} } @article{shahidehpour2021-33422891, author = {Shahidehpour, R. K. and Higdon, R. E. and Crawford, N. G. and Neltner, J. H. and Ighodaro, E. T. and Patel, E. and Price, D. and Nelson, P. T. and others}, title = {{Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain}}, journal = {Neurobiology of aging}, year = {2021}, doi = {10.1016/j.neurobiolaging.2020.12.003}, pmid = {33422891}, url = {https://doi.org/10.1016/j.neurobiolaging.2020.12.003} } @article{guan2025-40370691, author = {Guan, Dylan X. and Aundhakar, Aditya and Farias, Sarah Tomaszewski and Ballard, Clive G. and Creese, Byron and Corbett, Anne and Pickering, Ellie and Roach, Pamela and others}, title = {{Vascular risk factor associations with subjective cognitive decline and mild behavioural impairment}}, journal = {Brain Communications}, year = {2025}, doi = {10.1093/braincomms/fcaf163}, pmid = {40370691}, url = {https://doi.org/10.1093/braincomms/fcaf163} } @article{badrzadeh2025-41431429, author = {Badrzadeh, Fariba and Karimigharighi, Elham and Liang, Huajun and Chan, Andrew and Chang, Linda Dongxia and Liu, Peiying}, title = {{Association Between Gas‐Free Cerebrovascular Reactivity ( CVR ) and Cognitive Function in Older Adults With a High Risk for Vascular Dementia}}, journal = {Journal of Magnetic Resonance Imaging}, year = {2025}, doi = {10.1002/jmri.70212}, pmid = {41431429}, url = {https://doi.org/10.1002/jmri.70212} } @article{kolo2025-41434410, author = {Kolo, Francis Babaman and Lu, Sophia Francesca DP and Beiser, Alexa S. and Francis, Lily and van Lent, Debora Melo and Goss, Monica and Saptaparni, Ghosh and Ting, Shu Jie and others}, title = {{Association of hearing loss to brain structure and cognition in the Framingham Heart Study}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70860_101741}, pmid = {41434410}, url = {https://doi.org/10.1002/alz70860_101741} } @article{askelandgjerde2025-40330223, author = {Askeland-Gjerde, Daniel E. and Westlye, Lars Tjelta and Andersson, Patrik U. and Korbmacher, Max and de Lange, Ann‐Marie G. and van der Meer, Dennis and Smeland, Olav Bjerkehagen and Halvorsen, Sigrun and others}, title = {{Mediation Analyses Link Cardiometabolic Factors and Liver Fat With White Matter Hyperintensities and Cognitive Performance: A UK Biobank Study}}, journal = {Biological Psychiatry Global Open Science}, year = {2025}, doi = {10.1016/j.bpsgos.2025.100488}, pmid = {40330223}, url = {https://doi.org/10.1016/j.bpsgos.2025.100488} } @article{blair2025-40770920, author = {Blair, Gordon W. and MacCormick, Ian J. C. and McGrory, Sarah and MacGillivray, Tom and Hamilton, Iona F. and Shi, Yulu and Chappell, Francesca M. and Thrippleton, Michael J. and others}, title = {{Retinal vascular reactivity is associated with white matter hyperintensities and dysfunctional cerebrovascular reactivity in cerebral small vessel disease}}, journal = {Journal of Cerebral Blood Flow \& Metabolism}, year = {2025}, doi = {10.1177/0271678x251366079}, pmid = {40770920}, url = {https://doi.org/10.1177/0271678x251366079} } @article{wu2025-40260707, author = {Wu, Yilei and Dong, Zijian and Li, Hongwei and Chong, Yao Feng Victor and Ji, Fang and Chong, Joanna Su Xian and Tang, Nathanael Ren Jie and Hilal, Saima and others}, title = {{WMH ‐ DualTasker : A Weakly Supervised Deep Learning Model for Automated White Matter Hyperintensities Segmentation and Visual Rating Prediction}}, journal = {Human Brain Mapping}, year = {2025}, doi = {10.1002/hbm.70212}, pmid = {40260707}, url = {https://doi.org/10.1002/hbm.70212} } @article{ekenze2025-40867146, author = {Ekenze, Oluchi Stella and Pinheiro, Adlin and Beiser, Alexa S. and Lioutas, Vasileios‐Arsenios and Aparicio, Hugo Javier and Benjamin, Emelia J. and Vasan, Ramachandran Srini and DeCarli, Charles S and others}, title = {{Prevalent Cardiovascular Disease and Atrial Fibrillation in Relation to Cerebral Small Vessel Disease Burden}}, journal = {Brain Sciences}, year = {2025}, doi = {10.3390/brainsci15080813}, pmid = {40867146}, url = {https://doi.org/10.3390/brainsci15080813} } @article{zhang2026-42368465, author = {Zhang, Huixin and Guo, Tong and Zhang, Ran and Yan, Hongyi and Yang, Shuo and Gao, Y. and Wang, T T and Chen, Weiqi and others}, title = {{Clinical and neuroimaging correlates of motoric cognitive risk syndrome in cerebral small vessel disease: a cross-sectional study}}, journal = {Frontiers in Aging Neuroscience}, year = {2026}, doi = {10.3389/fnagi.2026.1853965}, pmid = {42368465}, url = {https://doi.org/10.3389/fnagi.2026.1853965} } @article{wang2025-40935402, author = {Wang, Yingzhe and Xie, Xiaodi and Xu, Jun Liang and Lei, Peng and Wang, Kai and Zhang, Junjian and Yu, Jintai and Cui, Mei and others}, title = {{Tongxinluo capsule in the treatment of cerebral small vessel disease: protocol of a randomised, double-blind, placebo-controlled, multicentre clinical study (TOPS-CSVD)}}, journal = {Stroke and Vascular Neurology}, year = {2025}, doi = {10.1136/svn-2024-003929}, pmid = {40935402}, url = {https://doi.org/10.1136/svn-2024-003929} } @article{chu2022-34906980, author = {Chu, W. T. and Wang, W. E. and Zaborszky, L. and Golde, T. E. and DeKosky, S. and Duara, R. and Loewenstein, D. A. and Adjouadi, M. and others}, title = {{Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000013206}, pmid = {34906980}, url = {https://doi.org/10.1212/wnl.0000000000013206} } @article{duncombe2017-28963120, author = {Duncombe, J. and Kitamura, A. and Hase, Y. and Ihara, M. and Kalaria, R. N. and Horsburgh, K.}, title = {{Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia}}, journal = {Clinical science (London, England : 1979)}, year = {2017}, doi = {10.1042/cs20160727}, pmid = {28963120}, url = {https://doi.org/10.1042/cs20160727} } @article{dai2008-18174483, author = {Dai, W. and Lopez, O. L. and Carmichael, O. T. and Becker, J. T. and Kuller, L. H. and Gach, H. M.}, title = {{Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension}}, journal = {Stroke}, year = {2008}, doi = {10.1161/strokeaha.107.495457}, pmid = {18174483}, url = {https://doi.org/10.1161/strokeaha.107.495457} } @article{chung2020-32150970, author = {Chung, H. Y. and Wickel, J. and Brunkhorst, F. M. and Geis, C.}, title = {{Sepsis-Associated Encephalopathy: From Delirium to Dementia?}}, journal = {Journal of clinical medicine}, year = {2020}, doi = {10.3390/jcm9030703}, pmid = {32150970}, url = {https://doi.org/10.3390/jcm9030703} } @article{wenning1998-9489528, author = {Wenning, G. K. and Litvan, I. and Jankovic, J. and Granata, R. and Mangone, C. A. and McKee, A. and Poewe, W. and Jellinger, K. and others}, title = {{Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {1998}, doi = {10.1136/jnnp.64.2.184}, pmid = {9489528}, url = {https://doi.org/10.1136/jnnp.64.2.184} } @article{wright2006-16501663, author = {Wright, C. B. and Sacco, R. L. and Rundek, T. and Delman, J. and Rabbani, L. and Elkind, M.}, title = {{Interleukin-6 is associated with cognitive function: the Northern Manhattan Study}}, journal = {Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association}, year = {2006}, doi = {10.1016/j.jstrokecerebrovasdis.2005.08.009}, pmid = {16501663}, url = {https://doi.org/10.1016/j.jstrokecerebrovasdis.2005.08.009} } @article{singhal2014-25339862, author = {Singhal, G. and Jaehne, E. J. and Corrigan, F. and Toben, C. and Baune, B. T.}, title = {{Inflammasomes in neuroinflammation and changes in brain function: a focused review}}, journal = {Frontiers in neuroscience}, year = {2014}, doi = {10.3389/fnins.2014.00315}, pmid = {25339862}, url = {https://doi.org/10.3389/fnins.2014.00315} } @article{farkas2007-17296232, author = {Farkas, E. and Luiten, P. G. and Bari, F.}, title = {{Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases}}, journal = {Brain research reviews}, year = {2007}, doi = {10.1016/j.brainresrev.2007.01.003}, pmid = {17296232}, url = {https://doi.org/10.1016/j.brainresrev.2007.01.003} } @article{park2014-24781082, author = {Park, L. and Koizumi, K. and El Jamal, S. and Zhou, P. and Previti, M. L. and Van Nostrand, W. E. and Carlson, G. and Iadecola, C.}, title = {{Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy}}, journal = {Stroke}, year = {2014}, doi = {10.1161/strokeaha.114.005179}, pmid = {24781082}, url = {https://doi.org/10.1161/strokeaha.114.005179} } @article{gui2022-35498045, author = {Gui, Y. and Zheng, H. and Cao, R. Y.}, title = {{Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms}}, journal = {Frontiers in cardiovascular medicine}, year = {2022}, doi = {10.3389/fcvm.2022.845942}, pmid = {35498045}, url = {https://doi.org/10.3389/fcvm.2022.845942} } @article{song2019-31363137, author = {Song, L. and Yuan, X. and Jones, Z. and Vied, C. and Miao, Y. and Marzano, M. and Hua, T. and Sang, Q. A. and others}, title = {{Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells}}, journal = {Scientific reports}, year = {2019}, doi = {10.1038/s41598-019-47444-6}, pmid = {31363137}, url = {https://doi.org/10.1038/s41598-019-47444-6} } @article{thomas2022-36376530, author = {Thomas, A. L. and Lehn, M. A. and Janssen, E. M. and Hildeman, D. A. and Chougnet, C. A.}, title = {{Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease}}, journal = {Scientific reports}, year = {2022}, doi = {10.1038/s41598-022-21920-y}, pmid = {36376530}, url = {https://doi.org/10.1038/s41598-022-21920-y} } @article{iddon1999-10567486, author = {Iddon, J. L. and Pickard, J. D. and Cross, J. J. and Griffiths, P. D. and Czosnyka, M. and Sahakian, B. J.}, title = {{Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {1999}, doi = {10.1136/jnnp.67.6.723}, pmid = {10567486}, url = {https://doi.org/10.1136/jnnp.67.6.723} } @article{cupido2022-35921096, author = {Cupido, A. J. and Reeskamp, L. F. and Hingorani, A. D. and Finan, C. and Asselbergs, F. W. and Hovingh, G. K. and Schmidt, A. F.}, title = {{Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study}}, journal = {JAMA cardiology}, year = {2022}, doi = {10.1001/jamacardio.2022.2333}, pmid = {35921096}, url = {https://doi.org/10.1001/jamacardio.2022.2333} } @article{smith2009-19443808, author = {Smith, E. E. and Greenberg, S. M.}, title = {{Beta-amyloid, blood vessels, and brain function}}, journal = {Stroke}, year = {2009}, doi = {10.1161/strokeaha.108.536839}, pmid = {19443808}, url = {https://doi.org/10.1161/strokeaha.108.536839} } @article{karve2016-25752446, author = {Karve, I. P. and Taylor, J. M. and Crack, P. J.}, title = {{The contribution of astrocytes and microglia to traumatic brain injury}}, journal = {British journal of pharmacology}, year = {2016}, doi = {10.1111/bph.13125}, pmid = {25752446}, url = {https://doi.org/10.1111/bph.13125} } @article{heusinkveld2016-27448464, author = {Heusinkveld, H. J. and Wahle, T. and Campbell, A. and Westerink, R. H. S. and Tran, L. and Johnston, H. and Stone, V. and Cassee, F. R. and others}, title = {{Neurodegenerative and neurological disorders by small inhaled particles}}, journal = {Neurotoxicology}, year = {2016}, doi = {10.1016/j.neuro.2016.07.007}, pmid = {27448464}, url = {https://doi.org/10.1016/j.neuro.2016.07.007} } @article{wang2012-23238711, author = {Wang, M. and Iliff, J. J. and Liao, Y. and Chen, M. J. and Shinseki, M. S. and Venkataraman, A. and Cheung, J. and Wang, W. and others}, title = {{Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2012}, doi = {10.1523/jneurosci.1860-12.2012}, pmid = {23238711}, url = {https://doi.org/10.1523/jneurosci.1860-12.2012} } @article{farkas2004-15138777, author = {Farkas, E. and Donka, G. and de Vos, R. A. and Mihály, A. and Bari, F. and Luiten, P. G.}, title = {{Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain}}, journal = {Acta neuropathologica}, year = {2004}, doi = {10.1007/s00401-004-0864-9}, pmid = {15138777}, url = {https://doi.org/10.1007/s00401-004-0864-9} } @article{altschuler2025-40797280, author = {Altschuler, Florencia and Canziani, Verónica and Fraile-Vazquez, Matias E and González-Gómez, Raúl and Hernández, Hernán Guillermo and Báez, Sandra and Migeot, Joaquín and Fittipaldi, Sol and others}, title = {{White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study}}, journal = {Alzheimer s Research \& Therapy}, year = {2025}, doi = {10.1186/s13195-025-01832-5}, pmid = {40797280}, url = {https://doi.org/10.1186/s13195-025-01832-5} } @article{mahammedi2025-40506229, author = {Mahammedi, Abdelkader and Fettahoglu, Ates and Heit, Jeremy Josef and Wardlaw, Joanna Marguerite and Zaharchuk, Greg}, title = {{Arterial Spin-Labeling MRI Identifies Abnormal Perfusion Metric at the Gray Matter/CSF Interface in Cerebral Small Vessel Disease}}, journal = {American Journal of Neuroradiology}, year = {2025}, doi = {10.3174/ajnr.a8682}, pmid = {40506229}, url = {https://doi.org/10.3174/ajnr.a8682} } @article{chen2025-39863325, author = {Chen, James Xiao Yuan and Vipin, Ashwati and Sandhu, Gurveen Kaur and Leow, Yi Jin and Zailan, Fatin Zahra and Tanoto, Pricilia and Lee, Ee Soo and Lee, Khang Leng and others}, title = {{Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2024.100029}, pmid = {39863325}, url = {https://doi.org/10.1016/j.tjpad.2024.100029} } @article{huang2025-39921653, author = {Huang, Yixuan and Shang, Li and Li, Bo and Wang, Tianyi and Zhang, Xiao and Wei, Junji and Mao, Chenhui and Gao, Jing}, title = {{Normal pressure hydrocephalus combined with quadruple misfolded proteinopathy: An autopsy case report and a short review of literature}}, journal = {Journal of Neuropathology \& Experimental Neurology}, year = {2025}, doi = {10.1093/jnen/nlaf006}, pmid = {39921653}, url = {https://doi.org/10.1093/jnen/nlaf006} } @article{hein2025-40322968, author = {Hein, Zaw Myo and Nassir, Che Mohd Nasril Che Mohd and Ramli, Muhammad Danial Che and Jaffer, Usman and Mehat, Muhammad Zulfadli and Mustapha, Muzaimi and Hamid, Hafizah Abdul}, title = {{Cerebral small vessel disease: The impact of glymphopathy and sleep disorders}}, journal = {Journal of Cerebral Blood Flow \& Metabolism}, year = {2025}, doi = {10.1177/0271678x251333933}, pmid = {40322968}, url = {https://doi.org/10.1177/0271678x251333933} } @article{vandijk2025-39950450, author = {van Dijk, Suzanne E. and Drenth, Nadieh and Hafkemeijer, Anne and Labadie, Gerda and Witjes‐Ané, Marie‐Noëlle W. and Baas, Frank F. and Vreijling, Jeroen P. and Blauw, Gerard J. and others}, title = {{Neurovascular Decoupling Is Associated With Lobar Intracerebral Hemorrhages and White Matter Hyperintensities}}, journal = {Journal of the American Heart Association}, year = {2025}, doi = {10.1161/jaha.124.038819}, pmid = {39950450}, url = {https://doi.org/10.1161/jaha.124.038819} } @article{pinheiro2025-41195792, author = {Pinheiro, Adlin and Aparicio, Hugo Javier and Lioutas, Vasileios‐Arsenios and Beiser, Alexa S. and Ekenze, Oluchi Stella and DeCarli, Charles S and Seshadri, Sudha S. and Demissie, Serkalem and others}, title = {{Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community‐Dwelling Individuals}}, journal = {Journal of the American Heart Association}, year = {2025}, doi = {10.1161/jaha.124.040263}, pmid = {41195792}, url = {https://doi.org/10.1161/jaha.124.040263} } @article{verstappen2025-40757800, author = {Verstappen, Damon and de Jong, Joost J.A. and Voorter, Paulien and van Dinther, Maud and van Oostenbrugge, Robert J. and Staals, Julie and Jansen, Jacobus F.A. and Backes, Walter H.}, title = {{DCE-MRI reveals spatial pattern in heterogeneous blood-brain barrier leakage within white matter in cerebral small vessel disease}}, journal = {Journal of Cerebral Blood Flow \& Metabolism}, year = {2025}, doi = {10.1177/0271678x251364151}, pmid = {40757800}, url = {https://doi.org/10.1177/0271678x251364151} } @article{reddy2025-40586237, author = {Reddy, Mallika and Li, June and Pajewski, Nicholas M. and Gaussoin, Sarah A. and Bryan, Robert Nick and Nasrallah, Ilya M. and Tamura, Manjula Kurella}, title = {{Cerebral small vessel disease and effects of intensive versus standard blood pressure treatment on cardiovascular outcomes and adverse events}}, journal = {Journal of Hypertension}, year = {2025}, doi = {10.1097/hjh.0000000000004093}, pmid = {40586237}, url = {https://doi.org/10.1097/hjh.0000000000004093} } @article{bohlen2019-31518519, author = {Bohlen, C. J. and Friedman, B. A. and Dejanovic, B. and Sheng, M.}, title = {{Microglia in Brain Development, Homeostasis, and Neurodegeneration}}, journal = {Annual review of genetics}, year = {2019}, doi = {10.1146/annurev-genet-112618-043515}, pmid = {31518519}, url = {https://doi.org/10.1146/annurev-genet-112618-043515} } @article{tarumi2018-28986925, author = {Tarumi, T. and Zhang, R.}, title = {{Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness}}, journal = {Journal of neurochemistry}, year = {2018}, doi = {10.1111/jnc.14234}, pmid = {28986925}, url = {https://doi.org/10.1111/jnc.14234} } @article{schubert2019-30850505, author = {Schubert, J. J. and Veronese, M. and Marchitelli, L. and Bodini, B. and Tonietto, M. and Stankoff, B. and Brooks, D. J. and Bertoldo, A. and others}, title = {{Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis}}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year = {2019}, doi = {10.2967/jnumed.118.223834}, pmid = {30850505}, url = {https://doi.org/10.2967/jnumed.118.223834} } @article{raji2014-25084680, author = {Raji, C. A. and Erickson, K. I. and Lopez, O. L. and Kuller, L. H. and Gach, H. M. and Thompson, P. M. and Riverol, M. and Becker, J. T.}, title = {{Regular fish consumption and age-related brain gray matter loss}}, journal = {American journal of preventive medicine}, year = {2014}, doi = {10.1016/j.amepre.2014.05.037}, pmid = {25084680}, url = {https://doi.org/10.1016/j.amepre.2014.05.037} } @article{zarei2009-19164789, author = {Zarei, M. and Damoiseaux, J. S. and Morgese, C. and Beckmann, C. F. and Smith, S. M. and Matthews, P. M. and Scheltens, P. and Rombouts, S. A. and others}, title = {{Regional white matter integrity differentiates between vascular dementia and Alzheimer disease}}, journal = {Stroke}, year = {2009}, doi = {10.1161/strokeaha.108.530832}, pmid = {19164789}, url = {https://doi.org/10.1161/strokeaha.108.530832} } @article{gutierrez2013-23557952, author = {Gutierrez, J. and Rundek, T. and Ekind, M. S. and Sacco, R. L. and Wright, C. B.}, title = {{Perivascular spaces are associated with atherosclerosis: an insight from the Northern Manhattan Study}}, journal = {AJNR. American journal of neuroradiology}, year = {2013}, doi = {10.3174/ajnr.a3498}, pmid = {23557952}, url = {https://doi.org/10.3174/ajnr.a3498} } @article{pires2013-23585139, author = {Pires, P. W. and Dams Ramos, C. M. and Matin, N. and Dorrance, A. M.}, title = {{The effects of hypertension on the cerebral circulation}}, journal = {American journal of physiology. Heart and circulatory physiology}, year = {2013}, doi = {10.1152/ajpheart.00490.2012}, pmid = {23585139}, url = {https://doi.org/10.1152/ajpheart.00490.2012} } @article{brown2011-20946471, author = {Brown, W. R. and Thore, C. R.}, title = {{Review: cerebral microvascular pathology in ageing and neurodegeneration}}, journal = {Neuropathology and applied neurobiology}, year = {2011}, doi = {10.1111/j.1365-2990.2010.01139.x}, pmid = {20946471}, url = {https://doi.org/10.1111/j.1365-2990.2010.01139.x} } @article{zhang2017-27908711, author = {Zhang, N. and Gordon, M. L. and Goldberg, T. E.}, title = {{Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease}}, journal = {Neuroscience and biobehavioral reviews}, year = {2017}, doi = {10.1016/j.neubiorev.2016.11.023}, pmid = {27908711}, url = {https://doi.org/10.1016/j.neubiorev.2016.11.023} } @article{lutsey2016-27415826, author = {Lutsey, P. L. and Norby, F. L. and Gottesman, R. F. and Mosley, T. and MacLehose, R. F. and Punjabi, N. M. and Shahar, E. and Jack, C. R. and others}, title = {{Sleep Apnea, Sleep Duration and Brain MRI Markers of Cerebral Vascular Disease and Alzheimer's Disease: The Atherosclerosis Risk in Communities Study (ARIC)}}, journal = {PloS one}, year = {2016}, doi = {10.1371/journal.pone.0158758}, pmid = {27415826}, url = {https://doi.org/10.1371/journal.pone.0158758} } @article{dimarco2015-26311408, author = {Di Marco, L. Y. and Venneri, A. and Farkas, E. and Evans, P. C. and Marzo, A. and Frangi, A. F.}, title = {{Vascular dysfunction in the pathogenesis of Alzheimer's disease--A review of endothelium-mediated mechanisms and ensuing vicious circles}}, journal = {Neurobiology of disease}, year = {2015}, doi = {10.1016/j.nbd.2015.08.014}, pmid = {26311408}, url = {https://doi.org/10.1016/j.nbd.2015.08.014} } @article{faraco2017-28782084, author = {Faraco, G. and Park, L. and Anrather, J. and Iadecola, C.}, title = {{Brain perivascular macrophages: characterization and functional roles in health and disease}}, journal = {Journal of molecular medicine (Berlin, Germany)}, year = {2017}, doi = {10.1007/s00109-017-1573-x}, pmid = {28782084}, url = {https://doi.org/10.1007/s00109-017-1573-x} } @article{kawazoe2025-40007723, author = {Kawazoe, Miki and Koga, Shunsuke and Sekiya, Hiroaki and Josephs, Keith A. and Graff‐Radford, Neill R. and Dickson, Dennis W.}, title = {{Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy}}, journal = {Neurology Clinical Practice}, year = {2025}, doi = {10.1212/cpj.0000000000200431}, pmid = {40007723}, url = {https://doi.org/10.1212/cpj.0000000000200431} } @article{li2025-40888555, author = {Li, Yang and Wang, Jiao and Miao, Yuyang and Dunk, Michelle M. and Liu, Yan and Fang, Zhongze and Zhang, Qiang and Xu, Weili}, title = {{Association Between Plasma Metabolomic Profile and Machine Learning‐Based Brain Age}}, journal = {Aging Cell}, year = {2025}, doi = {10.1111/acel.70208}, pmid = {40888555}, url = {https://doi.org/10.1111/acel.70208} } @article{ungvari2025-40113668, author = {Ungvari, Anna and Nyúl‐Tóth, Ádám and Patai, Roland and Csík, Boglárka and Gulej, Rafał and Nagy, Dorina and Shanmugarama, Santny and Benyó, Zoltán and others}, title = {{Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?}}, journal = {GeroScience}, year = {2025}, doi = {10.1007/s11357-025-01621-w}, pmid = {40113668}, url = {https://doi.org/10.1007/s11357-025-01621-w} } @article{hannan2025-40413732, author = {Hannan, Jade and Newman-Norlund, Sarah E. and Busby, Natalie and Wilson, Sarah C. and Newman‐Norlund, Roger and Rorden, Chris and Fridriksson, Julius and Bonilha, Leonardo and others}, title = {{Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan}}, journal = {Annals of Clinical and Translational Neurology}, year = {2025}, doi = {10.1002/acn3.70086}, pmid = {40413732}, url = {https://doi.org/10.1002/acn3.70086} } @article{che2025-40622016, author = {Che, Ping and Wang, Siqi and Liu, Xiaojiao and Lu, Yunyao and Tian, Zhuo and Feng, Qixin and Chen, Feifan and Zhang, Nan}, title = {{Plasma placental growth factor as a biomarker for subcortical ischemic vascular dementia and its cognitive correlation mediated by white matter hyperintensities}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70461}, pmid = {40622016}, url = {https://doi.org/10.1002/alz.70461} } @article{petersen2025-41105896, author = {Petersen, Marvin and Emskötter, David and Nägele, Felix Leonard and Mayer, Carola and Schell, Maximilian and Fiehler, Jens and Gallinat, Jürgen and Kühn, Simone and others}, title = {{Mapping the Association of Cerebral Small Vessel Disease, Gray Matter Integrity, and Cognitive Function}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000214215}, pmid = {41105896}, url = {https://doi.org/10.1212/wnl.0000000000214215} } @article{keller2025-40194370, author = {Keller, Jasmin Annica and Sigurdsson, Sigurdur Oli and Launer, Lenore J. and van Buchem, Mark A. and van Osch, Matthias J.P. and Gudnason, Vilmundur G. and de Bresser, Jeroen}, title = {{A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults}}, journal = {Neurobiology of Aging}, year = {2025}, doi = {10.1016/j.neurobiolaging.2025.03.011}, pmid = {40194370}, url = {https://doi.org/10.1016/j.neurobiolaging.2025.03.011} } @article{genius2026-41561329, author = {Genius, Patricia and Rodríguez‐Fernández, Blanca and Minguillón, Carolina and Anna, Brugulat-Serrat and Huguet, Jordi and Esteller, Manel and Sudre, Carole H. and Cortés‐Canteli, Marta and others}, title = {{Polygenic risk for white matter hyperintensities is associated with early cerebrovascular events partly through hemodynamic measures in cognitively unimpaired middle-aged and older adults with low cardiovascular risk}}, journal = {Frontiers in Neurology}, year = {2026}, doi = {10.3389/fneur.2025.1667424}, pmid = {41561329}, url = {https://doi.org/10.3389/fneur.2025.1667424} } @article{giannini2022-36071460, author = {Giannini, G. and Baiardi, S. and Dellavalle, S. and Zenesini, C. and Cevoli, S. and Danner, N. and Jyrkkänen, H. K. and Rossi, M. and others}, title = {{In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome}}, journal = {Fluids and barriers of the CNS}, year = {2022}, doi = {10.1186/s12987-022-00368-2}, pmid = {36071460}, url = {https://doi.org/10.1186/s12987-022-00368-2} } @article{vijayan2016-27567871, author = {Vijayan, M. and Reddy, P. H.}, title = {{Stroke, Vascular Dementia, and Alzheimer's Disease: Molecular Links}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2016}, doi = {10.3233/jad-160527}, pmid = {27567871}, url = {https://doi.org/10.3233/jad-160527} } @article{weller2015-25521178, author = {Weller, R. O. and Hawkes, C. A. and Kalaria, R. N. and Werring, D. J. and Carare, R. O.}, title = {{White matter changes in dementia: role of impaired drainage of interstitial fluid}}, journal = {Brain pathology (Zurich, Switzerland)}, year = {2015}, doi = {10.1111/bpa.12218}, pmid = {25521178}, url = {https://doi.org/10.1111/bpa.12218} } @article{sorop2017-28482008, author = {Sorop, O. and Olver, T. D. and van de Wouw, J. and Heinonen, I. and van Duin, R. W. and Duncker, D. J. and Merkus, D.}, title = {{The microcirculation: a key player in obesity-associated cardiovascular disease}}, journal = {Cardiovascular research}, year = {2017}, doi = {10.1093/cvr/cvx093}, pmid = {28482008}, url = {https://doi.org/10.1093/cvr/cvx093} } @article{awad1986-3810705, author = {Awad, I. A. and Spetzler, R. F. and Hodak, J. A. and Awad, C. A. and Carey, R.}, title = {{Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors}}, journal = {Stroke}, year = {1986}, doi = {10.1161/01.str.17.6.1084}, pmid = {3810705}, url = {https://doi.org/10.1161/01.str.17.6.1084} } @article{mellon2015-25879880, author = {Mellon, L. and Brewer, L. and Hall, P. and Horgan, F. and Williams, D. and Hickey, A. and {ASPIRE-S study group}}, title = {{Cognitive impairment six months after ischaemic stroke: a profile from the ASPIRE-S study}}, journal = {BMC neurology}, year = {2015}, doi = {10.1186/s12883-015-0288-2}, pmid = {25879880}, url = {https://doi.org/10.1186/s12883-015-0288-2} } @article{hiraoka2008-18497491, author = {Hiraoka, K. and Meguro, K. and Mori, E.}, title = {{Prevalence of idiopathic normal-pressure hydrocephalus in the elderly population of a Japanese rural community}}, journal = {Neurologia medico-chirurgica}, year = {2008}, doi = {10.2176/nmc.48.197}, pmid = {18497491}, url = {https://doi.org/10.2176/nmc.48.197} } @article{wang2018-30505270, author = {Wang, F. and Cao, Y. and Ma, L. and Pei, H. and Rausch, W. D. and Li, H.}, title = {{Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia}}, journal = {Frontiers in aging neuroscience}, year = {2018}, doi = {10.3389/fnagi.2018.00376}, pmid = {30505270}, url = {https://doi.org/10.3389/fnagi.2018.00376} } @article{kawasaki2010-20576949, author = {Kawasaki, R. and Cheung, N. and Mosley, T. and Islam, A. F. and Sharrett, A. R. and Klein, R. and Coker, L. H. and Knopman, D. S. and others}, title = {{Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study}}, journal = {Stroke}, year = {2010}, doi = {10.1161/strokeaha.110.585042}, pmid = {20576949}, url = {https://doi.org/10.1161/strokeaha.110.585042} } @article{zuurbier2015-26206535, author = {Zuurbier, L. A. and Ikram, M. A. and Luik, A. I. and Hofman, A. and Van Someren, E. J. and Vernooij, M. W. and Tiemeier, H.}, title = {{Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study}}, journal = {European journal of neurology}, year = {2015}, doi = {10.1111/ene.12775}, pmid = {26206535}, url = {https://doi.org/10.1111/ene.12775} } @article{thal2003-14692704, author = {Thal, D. R. and Ghebremedhin, E. and Orantes, M. and Wiestler, O. D.}, title = {{Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline}}, journal = {Journal of neuropathology and experimental neurology}, year = {2003}, doi = {10.1093/jnen/62.12.1287}, pmid = {14692704}, url = {https://doi.org/10.1093/jnen/62.12.1287} } @article{dekosky2013-23558985, author = {DeKosky, S. T. and Blennow, K. and Ikonomovic, M. D. and Gandy, S.}, title = {{Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers}}, journal = {Nature reviews. Neurology}, year = {2013}, doi = {10.1038/nrneurol.2013.36}, pmid = {23558985}, url = {https://doi.org/10.1038/nrneurol.2013.36} } @article{nwaobi2016-26961251, author = {Nwaobi, S. E. and Cuddapah, V. A. and Patterson, K. C. and Randolph, A. C. and Olsen, M. L.}, title = {{The role of glial-specific Kir4.1 in normal and pathological states of the CNS}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-016-1553-1}, pmid = {26961251}, url = {https://doi.org/10.1007/s00401-016-1553-1} } @article{rosenberg2001-11340226, author = {Rosenberg, G. A. and Sullivan, N. and Esiri, M. M.}, title = {{White matter damage is associated with matrix metalloproteinases in vascular dementia}}, journal = {Stroke}, year = {2001}, doi = {10.1161/01.str.32.5.1162}, pmid = {11340226}, url = {https://doi.org/10.1161/01.str.32.5.1162} } @article{george2025-41435845, author = {George, Grace C. and Keller, Sarah A. and Powell, W. Ryan and Buckingham, William R. and Bendlin, Barbara B. and Abner, Erin L. and Apostolova, Liana G. and Carrión, Carmen I. and others}, title = {{Association of Neighborhood‐Level Disadvantage with Cerebrovascular Disease Neuropathology in a National Sample of Brain Donors}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70855_100558}, pmid = {41435845}, url = {https://doi.org/10.1002/alz70855_100558} } @article{lee2025-41408121, author = {Lee, Jung‐Won and Kim, Sung‐Hwan and Kim, Suhyung and Um, Yoo Hyun and Wang, Sheng‐Min and Kim, TaeYeong and Kim, Donghyeon and Lim, Hyun Kook and others}, title = {{Alzheimer-related individual factors modulate effects of transcranial direct current stimulation strength on white matter integrity in mild cognitive impairment}}, journal = {Scientific Reports}, year = {2025}, doi = {10.1038/s41598-025-27612-7}, pmid = {41408121}, url = {https://doi.org/10.1038/s41598-025-27612-7} } @article{chen2025-41430353, author = {Chen, Yufei and Kwapong, William Robert and Chen, Xu and Gao, Yuan and Chu, Min and Zhang, Xuxiang and Wu, Liyong}, title = {{Retinal microvascular alterations reflect cerebral small vessel disease burden in frontotemporal dementia: a multimodal OCTA–MRI Study}}, journal = {Alzheimer s Research \& Therapy}, year = {2025}, doi = {10.1186/s13195-025-01945-x}, pmid = {41430353}, url = {https://doi.org/10.1186/s13195-025-01945-x} } @article{yang2025-41010812, author = {Yang, Han‐Mo}, title = {{Vascular Dementia: From Pathophysiology to Therapeutic Frontiers}}, journal = {Journal of Clinical Medicine}, year = {2025}, doi = {10.3390/jcm14186611}, pmid = {41010812}, url = {https://doi.org/10.3390/jcm14186611} } @article{tian2025-40592323, author = {Tian, Min and Kawaguchi, Riki and Shen, Yang and Machnicki, Michał and Villegas, Nikole G. and Cooper, Delaney R. and Montgomery, Natalia and Cai, Ying and others}, title = {{Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications}}, journal = {Cell}, year = {2025}, doi = {10.1016/j.cell.2025.06.002}, pmid = {40592323}, url = {https://doi.org/10.1016/j.cell.2025.06.002} } @article{luo2026-41578396, author = {Luo, Lixin and Qiao, Song}, title = {{Neuroinflammation and blood–brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications}}, journal = {European journal of medical research}, year = {2026}, doi = {10.1186/s40001-026-03840-z}, pmid = {41578396}, url = {https://doi.org/10.1186/s40001-026-03840-z} } @article{ziegler2025-41173000, author = {Ziegler, Kevin Chris and Askarova, Aydan and Gergian, Charbel and Yaa, Reuben M and van Dalen, Janna D. and Transfeld, Janis Lisa and Zoppi, Filippo and Du, Jia and others}, title = {{The brain neurovascular epigenome and its association with dementia}}, journal = {Neuron}, year = {2025}, doi = {10.1016/j.neuron.2025.10.001}, pmid = {41173000}, url = {https://doi.org/10.1016/j.neuron.2025.10.001} } @article{jin2025-41234528, author = {Jin, Xinhu and Xing, Yi and Lyu, Baihan and Ding, Junhua and Wang, Xiuyi and Du, Yi and Tang, Yi}, title = {{Cognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment}}, journal = {Brain Communications}, year = {2025}, doi = {10.1093/braincomms/fcaf394}, pmid = {41234528}, url = {https://doi.org/10.1093/braincomms/fcaf394} } @article{leone2025-40712373, author = {Leone, Riccardo and Kobeleva, Xenia}, title = {{White matter hyperintensities contribute to early cortical thinning in addition to tau in aging}}, journal = {Neurobiology of Aging}, year = {2025}, doi = {10.1016/j.neurobiolaging.2025.07.007}, pmid = {40712373}, url = {https://doi.org/10.1016/j.neurobiolaging.2025.07.007} } @article{li2026-41499267, author = {Li, Aonan and Liu, Lei and Bian, Yueyan and Lu, Yuanyuan and Jia, Xiuqin and Chen, Yuanyuan and Tang, Yi and Xing, Yi}, title = {{Silent yet impaired: Hidden memory processing deficits in asymptomatic individuals with moderate‐to‐severe white matter hyperintensities}}, journal = {Alzheimer s \& Dementia}, year = {2026}, doi = {10.1002/alz.71084}, pmid = {41499267}, url = {https://doi.org/10.1002/alz.71084} } @article{zwirner2021-34114049, author = {Zwirner, J. and Lier, J. and Franke, H. and Hammer, N. and Matschke, J. and Trautz, F. and Tse, R. and Ondruschka, B.}, title = {{GFAP positivity in neurons following traumatic brain injuries}}, journal = {International journal of legal medicine}, year = {2021}, doi = {10.1007/s00414-021-02568-1}, pmid = {34114049}, url = {https://doi.org/10.1007/s00414-021-02568-1} } @article{anad2022-35086142, author = {Anad, A. and Barker, M. K. and Katanga, J. A. and Arfanakis, K. and Bridges, L. R. and Esiri, M. M. and Isaacs, J. D. and Prpar Mihevc, S. and others}, title = {{Vasculocentric Axonal NfH in Small Vessel Disease}}, journal = {Journal of neuropathology and experimental neurology}, year = {2022}, doi = {10.1093/jnen/nlab134}, pmid = {35086142}, url = {https://doi.org/10.1093/jnen/nlab134} } @article{kalaria2010-21091952, author = {Kalaria, R. N.}, title = {{Vascular basis for brain degeneration: faltering controls and risk factors for dementia}}, journal = {Nutrition reviews}, year = {2010}, doi = {10.1111/j.1753-4887.2010.00352.x}, pmid = {21091952}, url = {https://doi.org/10.1111/j.1753-4887.2010.00352.x} } @article{takechi2017-29249964, author = {Takechi, R. and Lam, V. and Brook, E. and Giles, C. and Fimognari, N. and Mooranian, A. and Al-Salami, H. and Coulson, S. H. and others}, title = {{Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00399}, pmid = {29249964}, url = {https://doi.org/10.3389/fnagi.2017.00399} } @article{avery2020-31659926, author = {Avery, E. W. and Yoo, K. and Rosenberg, M. D. and Greene, A. S. and Gao, S. and Na, D. L. and Scheinost, D. and Constable, T. R. and others}, title = {{Distributed Patterns of Functional Connectivity Predict Working Memory Performance in Novel Healthy and Memory-impaired Individuals}}, journal = {Journal of cognitive neuroscience}, year = {2020}, doi = {10.1162/jocn_a_01487}, pmid = {31659926}, url = {https://doi.org/10.1162/jocn_a_01487} } @article{kaiser2014-25519173, author = {Kaiser, D. and Weise, G. and Möller, K. and Scheibe, J. and Pösel, C. and Baasch, S. and Gawlitza, M. and Lobsien, D. and others}, title = {{Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease}}, journal = {Acta neuropathologica communications}, year = {2014}, doi = {10.1186/s40478-014-0169-8}, pmid = {25519173}, url = {https://doi.org/10.1186/s40478-014-0169-8} } @article{akinyemi2019-29807146, author = {Akinyemi, R. O. and Owolabi, M. O. and Ihara, M. and Damasceno, A. and Ogunniyi, A. and Dotchin, C. and Paddick, S. M. and Ogeng'o, J. and others}, title = {{Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa}}, journal = {Brain research bulletin}, year = {2019}, doi = {10.1016/j.brainresbull.2018.05.018}, pmid = {29807146}, url = {https://doi.org/10.1016/j.brainresbull.2018.05.018} } @article{vanosch2018-28598243, author = {van Osch, M. J. and Teeuwisse, W. M. and Chen, Z. and Suzuki, Y. and Helle, M. and Schmid, S.}, title = {{Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow}}, journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year = {2018}, doi = {10.1177/0271678x17713434}, pmid = {28598243}, url = {https://doi.org/10.1177/0271678x17713434} } @article{kempler1990-1704428, author = {Kempler, D. and Metter, E. J. and Riege, W. H. and Jackson, C. A. and Benson, D. F. and Hanson, W. R.}, title = {{Slowly progressive aphasia: three cases with language, memory, CT and PET data}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {1990}, doi = {10.1136/jnnp.53.11.987}, pmid = {1704428}, url = {https://doi.org/10.1136/jnnp.53.11.987} } @article{golubnitschaja2022-36415625, author = {Golubnitschaja, O. and Potuznik, P. and Polivka, J. and Pesta, M. and Kaverina, O. and Pieper, C. C. and Kropp, M. and Thumann, G. and others}, title = {{Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach}}, journal = {The EPMA journal}, year = {2022}, doi = {10.1007/s13167-022-00307-z}, pmid = {36415625}, url = {https://doi.org/10.1007/s13167-022-00307-z} } @article{ghoshhajra2016-27242415, author = {Ghosh Hajra, S. and Liu, C. C. and Song, X. and Fickling, S. and Liu, L. E. and Pawlowski, G. and Jorgensen, J. K. and Smith, A. M. and others}, title = {{Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes Over Time}}, journal = {Frontiers in neuroscience}, year = {2016}, doi = {10.3389/fnins.2016.00211}, pmid = {27242415}, url = {https://doi.org/10.3389/fnins.2016.00211} } @article{xie2012-22776459, author = {Xie, C. and Bai, F. and Yu, H. and Shi, Y. and Yuan, Y. and Chen, G. and Li, W. and others}, title = {{Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment}}, journal = {NeuroImage}, year = {2012}, doi = {10.1016/j.neuroimage.2012.06.062}, pmid = {22776459}, url = {https://doi.org/10.1016/j.neuroimage.2012.06.062} } @article{grassivaro2020-31818979, author = {Grassivaro, F. and Menon, R. and Acquaviva, M. and Ottoboni, L. and Ruffini, F. and Bergamaschi, A. and Muzio, L. and Farina, C. and others}, title = {{Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2020}, doi = {10.1523/jneurosci.1523-19.2019}, pmid = {31818979}, url = {https://doi.org/10.1523/jneurosci.1523-19.2019} } @article{mangale2020-32449994, author = {Mangale, V. and Syage, A. R. and Ekiz, H. A. and Skinner, D. D. and Cheng, Y. and Stone, C. L. and Brown, R. M. and O'Connell, R. M. and others}, title = {{Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system}}, journal = {Glia}, year = {2020}, doi = {10.1002/glia.23844}, pmid = {32449994}, url = {https://doi.org/10.1002/glia.23844} } @article{bangen2017-28642699, author = {Bangen, K. J. and Clark, A. L. and Edmonds, E. C. and Evangelista, N. D. and Werhane, M. L. and Thomas, K. R. and Locano, L. E. and Tran, M. and others}, title = {{Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00181}, pmid = {28642699}, url = {https://doi.org/10.3389/fnagi.2017.00181} } @article{faden2016-25939377, author = {Faden, A. I. and Wu, J. and Stoica, B. A. and Loane, D. J.}, title = {{Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury}}, journal = {British journal of pharmacology}, year = {2016}, doi = {10.1111/bph.13179}, pmid = {25939377}, url = {https://doi.org/10.1111/bph.13179} } @article{zhao2025-40196107, author = {Zhao, Yilong and Xing, Wen Fang and Chen, Weiqi and Wang, Yilong}, title = {{Integrated bioinformatics analysis and biological experiments to identify key immune genes in vascular dementia}}, journal = {Frontiers in Immunology}, year = {2025}, doi = {10.3389/fimmu.2025.1560438}, pmid = {40196107}, url = {https://doi.org/10.3389/fimmu.2025.1560438} } @article{altahrawi2025-40277934, author = {Altahrawi, Aseel Y. and James, Antonisamy William and Shah, Zahoor Ahmad}, title = {{The Role of Oxidative Stress and Inflammation in the Pathogenesis and Treatment of Vascular Dementia}}, journal = {Cells}, year = {2025}, doi = {10.3390/cells14080609}, pmid = {40277934}, url = {https://doi.org/10.3390/cells14080609} } @article{alkuraishy2025-39832667, author = {Al-Kuraishy, Hayder Mutter and Al-Gareeb, Ali Ismail and Zekry, Salwa H and Alruwaili, Mubarak and Alexiou, Athanasios T. and Papadakis, Marios and Batiha, Gaber El‐Saber}, title = {{The possible role of cerebrolysin in the management of vascular dementia: Leveraging concepts}}, journal = {Neuroscience}, year = {2025}, doi = {10.1016/j.neuroscience.2025.01.040}, pmid = {39832667}, url = {https://doi.org/10.1016/j.neuroscience.2025.01.040} } @article{sawada2025-40567454, author = {Sawada, Yoichi and Satoh, Toru and Saba, Hideaki and Kato, Yoshiki and Kuwada, Tomoko and Shima, Sayoko and Murakami, Kana and Sasaki, Megumi and others}, title = {{Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample}}, journal = {Neuroimage Reports}, year = {2025}, doi = {10.1016/j.ynirp.2025.100264}, pmid = {40567454}, url = {https://doi.org/10.1016/j.ynirp.2025.100264} } @article{leng2025-40951922, author = {Leng, Kun and Maze, Mervyn and Chang, Odmara L. Barreto}, title = {{Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration}}, journal = {Frontiers in Aging Neuroscience}, year = {2025}, doi = {10.3389/fnagi.2025.1632947}, pmid = {40951922}, url = {https://doi.org/10.3389/fnagi.2025.1632947} } @article{mazzachi2026-41946741, author = {Mazzachi, Paris and McDonald, Ella and Greenberg, Zarina and Puerta, Alejandra Noreña and Tran, Jenne and De Silva, Manam Inushi and Christensen, Cade and Adams, Robert and others}, title = {{Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks}}, journal = {Nature Communications}, year = {2026}, doi = {10.1038/s41467-026-71112-9}, pmid = {41946741}, url = {https://doi.org/10.1038/s41467-026-71112-9} } @article{nowakowska2025-41009624, author = {Nowakowska, Karina and Walkiewicz, Grzegorz and Stec‐Martyna, Emilia and Kulczycka-Wojdala, Dominika and Frankowska, Emilia and Miler, Piotr and Pawlak, Agnieszka and Woźniak, Katarzyna and others}, title = {{Circulating Brain-Related miRNAs as Predictors of Postoperative Delirium in Cardiac Surgery Patients}}, journal = {International Journal of Molecular Sciences}, year = {2025}, doi = {10.3390/ijms26189062}, pmid = {41009624}, url = {https://doi.org/10.3390/ijms26189062} } @article{wang2025-40497513, author = {Wang, Youjie and Wang, Ruilin and Wang, Hang and Cao, Le and Ye, Chen and Liu, Junfeng and Wu, Bo and Kwapong, William Robert and others}, title = {{Choroidal Vascular Volume, White Matter Hyperintensity, and Their Interaction With Cognitive Function in Aging Adults}}, journal = {Journal of the American Heart Association}, year = {2025}, doi = {10.1161/jaha.124.039369}, pmid = {40497513}, url = {https://doi.org/10.1161/jaha.124.039369} } @article{gu2025-41137028, author = {Gu, Q. and Wang, S. and Zhu, L. and Sun, Q. and Zhang, Y.}, title = {{Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: a meta-analysis}}, journal = {AIDS research and therapy}, year = {2025}, doi = {10.1186/s12981-025-00804-x}, pmid = {41137028}, url = {https://doi.org/10.1186/s12981-025-00804-x} } @article{gasecki2013-24146223, author = {Gąsecki, D. and Kwarciany, M. and Nyka, W. and Narkiewicz, K.}, title = {{Hypertension, brain damage and cognitive decline}}, journal = {Current hypertension reports}, year = {2013}, doi = {10.1007/s11906-013-0398-4}, pmid = {24146223}, url = {https://doi.org/10.1007/s11906-013-0398-4} } @article{josephs2010-20629131, author = {Josephs, K. A. and Whitwell, J. L. and Boeve, B. F. and Knopman, D. S. and Petersen, R. C. and Hu, W. T. and Parisi, J. E. and Dickson, D. W. and others}, title = {{Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2010}, doi = {10.1002/mds.23062}, pmid = {20629131}, url = {https://doi.org/10.1002/mds.23062} } @article{schneider2015-24759546, author = {Schneider, A. L. and Sharrett, A. R. and Gottesman, R. F. and Coresh, J. and Coker, L. and Wruck, L. and Selnes, O. A. and Deal, J. and others}, title = {{Normative data for 8 neuropsychological tests in older blacks and whites from the atherosclerosis risk in communities (ARIC) study}}, journal = {Alzheimer disease and associated disorders}, year = {2015}, doi = {10.1097/wad.0000000000000042}, pmid = {24759546}, url = {https://doi.org/10.1097/wad.0000000000000042} } @article{elobeid2015-25868149, author = {Elobeid, A. and Laurell, K. and Cesarini, K. G. and Alafuzoff, I.}, title = {{Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus}}, journal = {Journal of neuropathology and experimental neurology}, year = {2015}, doi = {10.1097/nen.0000000000000191}, pmid = {25868149}, url = {https://doi.org/10.1097/nen.0000000000000191} } @article{shi2015-25285374, author = {Shi, J. and Stonnington, C. M. and Thompson, P. M. and Chen, K. and Gutman, B. and Reschke, C. and Baxter, L. C. and Reiman, E. M. and others}, title = {{Studying ventricular abnormalities in mild cognitive impairment with hyperbolic Ricci flow and tensor-based morphometry}}, journal = {NeuroImage}, year = {2015}, doi = {10.1016/j.neuroimage.2014.09.062}, pmid = {25285374}, url = {https://doi.org/10.1016/j.neuroimage.2014.09.062} } @article{hong2016-27230456, author = {Hong, H. and Kim, B. S. and Im, H. I.}, title = {{Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders}}, journal = {International neurourology journal}, year = {2016}, doi = {10.5213/inj.1632604.302}, pmid = {27230456}, url = {https://doi.org/10.5213/inj.1632604.302} } @article{faden2015-25421001, author = {Faden, A. I. and Loane, D. J.}, title = {{Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?}}, journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics}, year = {2015}, doi = {10.1007/s13311-014-0319-5}, pmid = {25421001}, url = {https://doi.org/10.1007/s13311-014-0319-5} } @article{bommarito2025-40646592, author = {Bommarito, Giulia and Griffa, Alessandra and Michel, Patrik and Caroline, Hall and Salvioni, Chiabotti Paolo and Pistocchi, Silvia and Alemán-Gómez, Yasser and Damian, Daniel and others}, title = {{Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer’s disease}}, journal = {Alzheimer s Research \& Therapy}, year = {2025}, doi = {10.1186/s13195-025-01805-8}, pmid = {40646592}, url = {https://doi.org/10.1186/s13195-025-01805-8} } @article{mastick2026-41607060, author = {Mastick, Maya L and Enkhtsetseg, Nomin and Sadok, Joseph and Mochetti, Matheus Menão and Sorby‐Adams, Annabel and Guo, Jennifer D. and Hacker, Cristina Trapaga and Hjerthen, Isabella Gomez and others}, title = {{Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort}}, journal = {Annals of Clinical and Translational Neurology}, year = {2026}, doi = {10.1002/acn3.70326}, pmid = {41607060}, url = {https://doi.org/10.1002/acn3.70326} } @article{patai2025-40169521, author = {Patai, Roland and Patel, Krish and Csík, Boglárka and Gulej, Rafał and Nagaraja, Raghavendra Yelahanka and Nagy, Dorina and Chandragiri, Siva Sai and Shanmugarama, Santny and others}, title = {{Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening}}, journal = {GeroScience}, year = {2025}, doi = {10.1007/s11357-025-01634-5}, pmid = {40169521}, url = {https://doi.org/10.1007/s11357-025-01634-5} } @article{ihuoma2026-41831270, author = {Ihuoma, Jennifer and Milan, Madison and Negri, Sharon and Troyano‐Rodriguez, Eva and Rudraboina, Rakesh and Kosmider, Aleksandra and Awasthi, Shantipriya and Csiszar, Anna and others}, title = {{LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia}}, journal = {Redox Biology}, year = {2026}, doi = {10.1016/j.redox.2026.104118}, pmid = {41831270}, url = {https://doi.org/10.1016/j.redox.2026.104118} } @article{ceccarelli2025-40137124, author = {Ceccarelli, Daniela Ceccarelli and Solerte, Sebastiano Bruno}, title = {{Unravelling Shared Pathways Linking Metabolic Syndrome, Mild Cognitive Impairment, Dementia, and Sarcopenia}}, journal = {Metabolites}, year = {2025}, doi = {10.3390/metabo15030159}, pmid = {40137124}, url = {https://doi.org/10.3390/metabo15030159} } @article{hadad2026-41799019, author = {Hadad, Rafi and Cobigo, Yann and Milicic, Andjelika and Tsoy, Elena and Mandelli, Maria Luisa and Wolf, Amy A. and Gaynor, Leslie S. and Possin, Katherine L. and others}, title = {{White Matter Hyperintensities in Behavioral Variant Frontotemporal Dementia and Semantic Variant Primary Progressive Aphasia}}, journal = {Neurology Open Access}, year = {2026}, doi = {10.1212/wn9.0000000000000064}, pmid = {41799019}, url = {https://doi.org/10.1212/wn9.0000000000000064} } @article{kwapong2026-41761865, author = {Kwapong, William Robert and Chen, Zheli and Wang, Youjie and Luan, Xiaoqian and Chen, Jiahui and Wen, Caiyun and Liu, Yinhe and Bonaventure, Ip Yiu Ming and others}, title = {{Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline}}, journal = {Alzheimer s \& Dementia}, year = {2026}, doi = {10.1002/alz.71216}, pmid = {41761865}, url = {https://doi.org/10.1002/alz.71216} } @article{chaar2025-40141087, author = {Chaar, Dima and Li, Zheng and Shang, Lulu and Ratliff, Scott M. and Mosley, Thomas H. and Kardia, Sharon L. R. and Zhao, Wei and Zhou, Xiang and others}, title = {{Multi-Ancestry Transcriptome-Wide Association Studies of Cognitive Function, White Matter Hyperintensity, and Alzheimer’s Disease}}, journal = {International Journal of Molecular Sciences}, year = {2025}, doi = {10.3390/ijms26062443}, pmid = {40141087}, url = {https://doi.org/10.3390/ijms26062443} } @article{ross2025-41138063, author = {Ross, Daliah and Chang, Fini and Edwards, Lauren and Thomas, Kelsey R. and Bangen, Katherine J. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Cognitive dispersion is associated with white matter hyperintensities in amyloid positive older adults}}, journal = {The Clinical Neuropsychologist}, year = {2025}, doi = {10.1080/13854046.2025.2570301}, pmid = {41138063}, url = {https://doi.org/10.1080/13854046.2025.2570301} } @article{vikner2025-40671018, author = {Vikner, Tomas P. and Garpebring, Anders and Björnfot, Cecilia and Malm, Jan and Eklund, Anders and Wåhlin, Anders}, title = {{MRI contrast accumulation in features of cerebral small vessel disease: blood-brain barrier dysfunction or elevated vascular density?}}, journal = {Fluids and Barriers of the CNS}, year = {2025}, doi = {10.1186/s12987-025-00675-4}, pmid = {40671018}, url = {https://doi.org/10.1186/s12987-025-00675-4} } @article{peterson2025-40352684, author = {Peterson, Amalia Jo and Sun, Yunyi and Archer, Derek B. and Kresge, Hailey A. and Moore, Elizabeth E. and Deberghes, Isabella and Pechman, Kimberly R. and Shashikumar, Niranjana and others}, title = {{Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period}}, journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring}, year = {2025}, doi = {10.1002/dad2.70110}, pmid = {40352684}, url = {https://doi.org/10.1002/dad2.70110} } @article{wang2026-41478827, author = {Wang, Han and Li, Zhi-Ming and Xiong, Benbo and Wang, Zi-Jie and Qian, Yi and Hu, Xiao and Zhang, Shan-Yu and Chen, Chu and others}, title = {{The association of estimated glucose disposal rate with white matter hyperintensities: A large prospective cohort study}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2026}, doi = {10.1016/j.tjpad.2025.100464}, pmid = {41478827}, url = {https://doi.org/10.1016/j.tjpad.2025.100464} } @article{hong2025-41128158, author = {Hong, Hui and Chen, Yutong and Tozer, Dan and Jiaerken, Yeerfan and Huang, Peiyu and Markus, Hugh Stephen}, title = {{MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70699}, pmid = {41128158}, url = {https://doi.org/10.1002/alz.70699} } @article{chen2025-39993085, author = {Chen, Haixu and Zeng, Lianlin}, title = {{Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology}}, journal = {Medicine}, year = {2025}, doi = {10.1097/md.0000000000041686}, pmid = {39993085}, url = {https://doi.org/10.1097/md.0000000000041686} } @article{kallai2025-40214958, author = {Kállai, Attila and Ungvari, Anna and Csabán, Dóra and Őrfi, Zoltán and Lehoczki, Andrea and Harasztdombi, József and Yabluchanskiy, Andriy and Benyó, Zoltán and others}, title = {{Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)}}, journal = {GeroScience}, year = {2025}, doi = {10.1007/s11357-025-01654-1}, pmid = {40214958}, url = {https://doi.org/10.1007/s11357-025-01654-1} } @article{lee2010-20595668, author = {Lee, D. Y. and Fletcher, E. and Martinez, O. and Zozulya, N. and Kim, J. and Tran, J. and Buonocore, M. and Carmichael, O. and others}, title = {{Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer disease}}, journal = {Stroke}, year = {2010}, doi = {10.1161/strokeaha.110.582163}, pmid = {20595668}, url = {https://doi.org/10.1161/strokeaha.110.582163} } @article{fu2019-31066686, author = {Fu, S. and Leung, L. Y. and Wang, Y. and Raulli, A. O. and Kallmes, D. F. and Kinsman, K. A. and Nelson, K. B. and Clark, M. S. and others}, title = {{Natural Language Processing for the Identification of Silent Brain Infarcts From Neuroimaging Reports}}, journal = {JMIR medical informatics}, year = {2019}, doi = {10.2196/12109}, pmid = {31066686}, url = {https://doi.org/10.2196/12109} } @article{lukiw2008-19022980, author = {Lukiw, W. J. and Bazan, N. G.}, title = {{Docosahexaenoic acid and the aging brain}}, journal = {The Journal of nutrition}, year = {2008}, doi = {10.3945/jn.108.096016}, pmid = {19022980}, url = {https://doi.org/10.3945/jn.108.096016} } @article{mukherjee2019-30733664, author = {Mukherjee, S. and Klaus, C. and Pricop-Jeckstadt, M. and Miller, J. A. and Struebing, F. L.}, title = {{A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks}}, journal = {Frontiers in neuroscience}, year = {2019}, doi = {10.3389/fnins.2019.00002}, pmid = {30733664}, url = {https://doi.org/10.3389/fnins.2019.00002} } @article{golomb2000-10811706, author = {Golomb, J. and Wisoff, J. and Miller, D. C. and Boksay, I. and Kluger, A. and Weiner, H. and Salton, J. and Graves, W.}, title = {{Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2000}, doi = {10.1136/jnnp.68.6.778}, pmid = {10811706}, url = {https://doi.org/10.1136/jnnp.68.6.778} } @article{bajaj2022-35537854, author = {Bajaj, Jasmohan Singh and Fagan, Andrew and McGeorge, Sara and Sterling, Richard K. and Rogal, Shari S. and Sikaroodi, Masoumeh and Gillevet, Patrick Martin}, title = {{Area Deprivation Index and Gut-Brain Axis in Cirrhosis}}, journal = {Clinical and Translational Gastroenterology}, year = {2022}, doi = {10.14309/ctg.0000000000000495}, pmid = {35537854}, url = {https://doi.org/10.14309/ctg.0000000000000495} } @article{antoine2023-37984835, author = {Antoine, Lisa H. and Tanner, Jared J. and Mickle, Angela M. and Gonzalez, Cesar E. and Kusko, Daniel A. and Allen-Watts, Kristen and Rumble, Deanna and Buchanan, Taylor and others}, title = {{Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes}}, journal = {Brain and Behavior}, year = {2023}, doi = {10.1002/brb3.3330}, pmid = {37984835}, url = {https://doi.org/10.1002/brb3.3330} } @article{bernhard2025-39826021, author = {Bernhard, Johannes and Galli, Lukas and Speidl, Walter Stefan and Krychtiuk, Konstantin Alexander}, title = {{Cardiovascular Risk Reduction in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis}}, journal = {Current Cardiology Reports}, year = {2025}, doi = {10.1007/s11886-024-02185-5}, pmid = {39826021}, url = {https://doi.org/10.1007/s11886-024-02185-5} } @article{mason2025-41388643, author = {Mason, Andrew C. and Fatih, Nasri and Sofat, Reecha and Rentsch, Christopher T. and Smeeth, Liam L and Bhaskaran, Krishnan and Chaturvedi, Nish and Garfield, Victoria}, title = {{Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study}}, journal = {Diabetes Obesity and Metabolism}, year = {2025}, doi = {10.1111/dom.70353}, pmid = {41388643}, url = {https://doi.org/10.1111/dom.70353} } @article{mayer2025-40254131, author = {Mayer, Meredith G. and Fischer, Tracy}, title = {{Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in Coronavirus Disease 2019 and Alzheimer Disease}}, journal = {American Journal Of Pathology}, year = {2025}, doi = {10.1016/j.ajpath.2025.03.011}, pmid = {40254131}, url = {https://doi.org/10.1016/j.ajpath.2025.03.011} } @article{ylmaz2025-40699631, author = {Yılmaz, Habibe and Bayraktutan, Ulvi}, title = {{Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction}}, journal = {Current Issues in Molecular Biology}, year = {2025}, doi = {10.3390/cimb47040232}, pmid = {40699631}, url = {https://doi.org/10.3390/cimb47040232} } @article{li2025-40967343, author = {Li, Kai and Bian, Yueyan and Xing, Yi and Jia, Xiuqin}, title = {{Altered glymphatic function and cerebrovascular reactivity in white matter hyperintensities: Insights into cognitive impairment}}, journal = {Brain Research Bulletin}, year = {2025}, doi = {10.1016/j.brainresbull.2025.111552}, pmid = {40967343}, url = {https://doi.org/10.1016/j.brainresbull.2025.111552} } @article{saeed2025-40034508, author = {Saeed, Anum and Chang, Yue-Fang and Swanson, Justin and Vu, Michael and Mapstone, Mark E. and Villemagne, Victor L. and Snitz, Beth Ellen and Royse, Sarah K. and others}, title = {{Association of mid-life cardiovascular risk with biomarkers of Alzheimer's disease, neurodegeneration, and white matter hyperintensities: Heart SCORE brain study}}, journal = {Journal of Alzheimer s Disease Reports}, year = {2025}, doi = {10.1177/25424823241299297}, pmid = {40034508}, url = {https://doi.org/10.1177/25424823241299297} } @article{prinse2025-40754329, author = {Prinse, F. A. M. and van der Weerd, L. and van Swieten, J. C. and Ronen, I. and Seelaar, H. and Hirschler, L. and Najac, C. and Dopper, E. G. P.}, title = {{Investigating the role of neuroinflammation and brain clearance in frontotemporal lobar degeneration using 7T MRI and fluid biomarkers: protocol for a cross-sectional study in a tertiary care setting}}, journal = {BMJ open}, year = {2025}, doi = {10.1136/bmjopen-2025-102668}, pmid = {40754329}, url = {https://doi.org/10.1136/bmjopen-2025-102668} } @article{bermudez2025-39085998, author = {Bermudez, C. and Lesnick, T. G. and More, S. S. and Ramanan, V. K. and Knopman, D. S. and Rabinstein, A. A. and Cogswell, P. M. and Jack, C. R. and others}, title = {{Optical Coherence Tomography Angiography Retinal Imaging Associations With Burden of Small Vessel Disease and Amyloid Positivity in the Brain}}, journal = {Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society}, year = {2025}, doi = {10.1097/wno.0000000000002230}, pmid = {39085998}, url = {https://doi.org/10.1097/wno.0000000000002230} } @article{wu2006-17097277, author = {Wu, M. and Rosano, C. and Butters, M. and Whyte, E. and Nable, M. and Crooks, R. and Meltzer, C. C. and others}, title = {{A fully automated method for quantifying and localizing white matter hyperintensities on MR images}}, journal = {Psychiatry research}, year = {2006}, doi = {10.1016/j.pscychresns.2006.09.003}, pmid = {17097277}, url = {https://doi.org/10.1016/j.pscychresns.2006.09.003} } @article{afridi2020-32903682, author = {Afridi, R. and Lee, W. H. and Suk, K.}, title = {{Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration}}, journal = {Frontiers in cellular neuroscience}, year = {2020}, doi = {10.3389/fncel.2020.00246}, pmid = {32903682}, url = {https://doi.org/10.3389/fncel.2020.00246} } @article{garciarevilla2019-31627485, author = {García-Revilla, J. and Alonso-Bellido, I. M. and Burguillos, M. A. and Herrera, A. J. and Espinosa-Oliva, A. M. and Ruiz, R. and Cruz-Hernández, L. and García-Domínguez, I. and others}, title = {{Reformulating Pro-Oxidant Microglia in Neurodegeneration}}, journal = {Journal of clinical medicine}, year = {2019}, doi = {10.3390/jcm8101719}, pmid = {31627485}, url = {https://doi.org/10.3390/jcm8101719} } @article{zhao2021-33953790, author = {Zhao, Z. J. and Wei, D. P. and Zheng, R. Z. and Peng, T. and Xiao, X. and Li, F. S.}, title = {{The Gene Coexpression Analysis Identifies Functional Modules Dynamically Changed After Traumatic Brain Injury}}, journal = {Computational and mathematical methods in medicine}, year = {2021}, doi = {10.1155/2021/5511598}, pmid = {33953790}, url = {https://doi.org/10.1155/2021/5511598} } @article{gootjes2004-15211074, author = {Gootjes, L. and Teipel, S. J. and Zebuhr, Y. and Schwarz, R. and Leinsinger, G. and Scheltens, P. and Möller, H. J. and Hampel, H.}, title = {{Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy aging}}, journal = {Dementia and geriatric cognitive disorders}, year = {2004}, doi = {10.1159/000079199}, pmid = {15211074}, url = {https://doi.org/10.1159/000079199} } @article{yadav2009-19768553, author = {Yadav, A. and Collman, R. G.}, title = {{CNS inflammation and macrophage/microglial biology associated with HIV-1 infection}}, journal = {Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology}, year = {2009}, doi = {10.1007/s11481-009-9174-2}, pmid = {19768553}, url = {https://doi.org/10.1007/s11481-009-9174-2} } @article{roscoe2024-c8841b99, author = {Roscoe, Joseph A. and Whitmer, Rachel A. and Gutierrez, Sirena and Eng, Chloe W. and Glymour, M. Maria and DeCarli, Charles S and Barnes, Lisa Laverne and Gavett, Brandon E. and others}, title = {{County‐level indicators of education quality and brain imaging markers of neurodegeneration and vascular injury among racially and ethnically diverse middle‐aged and older adults}}, journal = {Alzheimer s \& Dementia}, year = {2024}, doi = {10.1002/alz.093321}, url = {https://doi.org/10.1002/alz.093321} } @article{marsland2025-41257402, author = {Marsland, Anna L. and Wu, Minjie and DeCataldo, Mia K. and Aizenstein, Howard Jay and Li, Jinghang and Ibrahim, Tamer S. and Manuck, Stephen B. and Gianaros, Peter J.}, title = {{Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults}}, journal = {Psychosomatic Medicine}, year = {2025}, doi = {10.1097/psy.0000000000001453}, pmid = {41257402}, url = {https://doi.org/10.1097/psy.0000000000001453} } @article{naftali2025-41085237, author = {Naftali, Jonathan and Glik, Amir and Eliahou, Ruth and Rabninovici, Gil D and Rosen, Howar J and Elahi, Fanny M. and Benninger, Felix and Goldberg, Ilan and others}, title = {{Impact of cerebral small vessel disease on cognitive outcomes in early age at onset MCI and dementia: Findings from the DIASPORA study}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70773}, pmid = {41085237}, url = {https://doi.org/10.1002/alz.70773} } @article{moran2025-40119105, author = {Moran, Katie L. and Smith, Craig J. and McManus, Elizabeth and Allan, Stuart McRae and Montaldi, Daniela and Muhlert, Nils}, title = {{Cerebrovascular health impacts processing speed through anterior white matter alterations: a UK biobank study}}, journal = {Scientific Reports}, year = {2025}, doi = {10.1038/s41598-025-93399-2}, pmid = {40119105}, url = {https://doi.org/10.1038/s41598-025-93399-2} } @article{li2025-40611180, author = {Li, Pingan and Zhang, Haiping and Ma, Jianhua and Wang, Jinqi and Lv, Shiyun and Zhao, Xiaoyu and Yang, Xinghua and Luo, Yanxia and others}, title = {{Cardiovascular-kidney-metabolic syndrome, systemic inflammation, and incident dementia: evidence from 400,740 UK Biobank participants}}, journal = {Diabetology \& Metabolic Syndrome}, year = {2025}, doi = {10.1186/s13098-025-01805-6}, pmid = {40611180}, url = {https://doi.org/10.1186/s13098-025-01805-6} } @article{ferrarisouza2025-41449556, author = {Ferrari‐Souza, João Pedro and Povala, Guilherme and Rahmouni, Nesrine and Bellaver, Bruna and Ferreira, Pâmela C.L. and Leffa, Douglas Teixeira and Lussier, Firoza Zubeida and Aguzzoli, Cristiano Schaffer and others}, title = {{Microglia as a key player in Aβ‐related astrocyte reactivity}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70856_102677}, pmid = {41449556}, url = {https://doi.org/10.1002/alz70856_102677} } @article{mizutani2026-41964274, author = {Mizutani, Akane and Parra-Pérez, Carlos and Shindo, Akihiro and Lizasoaín, Ignacio and Moro, María Ángeles and Arai, Ken}, title = {{Neuroinflammation in vascular cognitive impairment and dementia: Insights from clinical biomarkers and experimental models}}, journal = {Journal of Cerebral Blood Flow \& Metabolism}, year = {2026}, doi = {10.1177/0271678x261437523}, pmid = {41964274}, url = {https://doi.org/10.1177/0271678x261437523} } @article{saks2025-39840612, author = {Saks, Danit and Sachdev, Perminder Singh}, title = {{Monogenic causes of cerebral small vessel disease- models for vascular cognitive impairment and dementia?}}, journal = {Current Opinion in Psychiatry}, year = {2025}, doi = {10.1097/yco.0000000000000978}, pmid = {39840612}, url = {https://doi.org/10.1097/yco.0000000000000978} } @article{raeesi2025-41399254, author = {Raeesi, Shima and Zeighami, Yashar and Moqadam, Roqaie and Morrison, Cassandra and Dadar, Mahsa}, title = {{Vascular risk factors mediate the relationship between education and white matter hyperintensities}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70972}, pmid = {41399254}, url = {https://doi.org/10.1002/alz.70972} } @article{thomas2025-41210610, author = {Thomas, Sarah T and Palanikumar, Logesh and Darby, David and Brodtmann, Amy G.}, title = {{FDG-PET anterior cingulate cortex hypometabolism as a marker of cerebral small vessel disease in Alzheimer's and vascular cognitive impairment and dementia}}, journal = {Cerebral Circulation - Cognition and Behavior}, year = {2025}, doi = {10.1016/j.cccb.2025.100404}, pmid = {41210610}, url = {https://doi.org/10.1016/j.cccb.2025.100404} } @article{tchuisseukwangoua2025-41182006, author = {Tchuisseu‐Kwangoua, Larissa Ange and Omarov, Murad and Shatunov, Aleksey and Markus, Hugh Stephen and Tatuene, Joseph Kamtchum and Georgakis, Marios K.}, title = {{Genetic Downregulation of Interleukin‐6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis}}, journal = {Journal of the American Heart Association}, year = {2025}, doi = {10.1161/jaha.124.041814}, pmid = {41182006}, url = {https://doi.org/10.1161/jaha.124.041814} } @article{low2025-41190623, author = {Low, Audrey and Tsvetanov, Kamen A. and Ntailianis, Georgios and Prats‐Sedano, Maria A and McKiernan, Elizabeth Frances and Carter, Stephen F. and Stefaniak, James D. and Nannoni, Stefania and others}, title = {{Neighborhood deprivation and midlife cognition: Evidence of a modifiable vascular pathway involving health behaviors and cerebral small vessel disease}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70756}, pmid = {41190623}, url = {https://doi.org/10.1002/alz.70756} } @article{bachmann2026-41906163, author = {Bachmann, Dario and Gericke, Christoph and Wybitul, Maha and Saake, Antje and Studer, Sandro T. and Rauen, Katrin and Gruber, Esmeralda and Buchmann, Andreas and others}, title = {{Independent and interactive contributions of white matter hyperintensities and Alzheimer’s disease imaging and plasma biomarkers to cognitive decline in older adults without dementia}}, journal = {Alzheimer s Research \& Therapy}, year = {2026}, doi = {10.1186/s13195-026-02038-z}, pmid = {41906163}, url = {https://doi.org/10.1186/s13195-026-02038-z} } @article{jin2025-40841915, author = {Jin, Xin and Zhou, Yanru and Zhang, Diwen and Xiu, Chen and Ruan, Jianghai and Fang, Dengfu}, title = {{Analysis of brain dynamics changes in patients with cerebral small vessel disease-related cognitive impairment based on electroencephalogram microstates}}, journal = {European journal of medical research}, year = {2025}, doi = {10.1186/s40001-025-03037-w}, pmid = {40841915}, url = {https://doi.org/10.1186/s40001-025-03037-w} } @article{mitchell2022-36714789, author = {Mitchell, C. and Gaitán, J. M. and Pewowaruk, R. J. and Gepner, A. D. and Hess, T. and Wilbrand, S. M. and Dempsey, R. J. and Dougherty, R. J. and others}, title = {{Transcranial Color-Coded Doppler Cerebral Hemodynamics Following Aerobic Exercise Training: Outcomes From a Pilot Randomized Clinical Trial}}, journal = {Journal for vascular ultrasound : JVU}, year = {2022}, doi = {10.1177/15443167221099274}, pmid = {36714789}, url = {https://doi.org/10.1177/15443167221099274} } @article{suarezsola2009-19543540, author = {Suárez-Solá, M. L. and González-Delgado, F. J. and Pueyo-Morlans, M. and Medina-Bolívar, O. C. and Hernández-Acosta, N. C. and González-Gómez, M. and Meyer, G.}, title = {{Neurons in the white matter of the adult human neocortex}}, journal = {Frontiers in neuroanatomy}, year = {2009}, doi = {10.3389/neuro.05.007.2009}, pmid = {19543540}, url = {https://doi.org/10.3389/neuro.05.007.2009} } @article{chu1998-9600195, author = {Chu, C. T. and Gray, L. and Goldstein, L. B. and Hulette, C. M.}, title = {{Diagnosis of intracranial vasculitis: a multi-disciplinary approach}}, journal = {Journal of neuropathology and experimental neurology}, year = {1998}, doi = {10.1097/00005072-199801000-00005}, pmid = {9600195}, url = {https://doi.org/10.1097/00005072-199801000-00005} } @article{shao2025-40145953, author = {Shao, Qi and Chen, Simin and Zheng, Yuxiao and Xu, Wen‐Xiu and Chen, Jiahui and Shao, Wei Dong and Wang, Qingguo and Li, Changxiang and others}, title = {{Crucial role of microglia-mediated myelin sheath damage in vascular dementia: Antecedents and consequences}}, journal = {Neural Regeneration Research}, year = {2025}, doi = {10.4103/nrr.nrr-d-24-01109}, pmid = {40145953}, url = {https://doi.org/10.4103/nrr.nrr-d-24-01109} } @article{yang2025-40136659, author = {Yang, Yujie and Deng, Chunchu and Aldali, Fatima and Huang, Yunjie and Luo, Hong and Liu, Yizhou and Huang, Danxia and Cao, Xiaojian and others}, title = {{Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia}}, journal = {Cells}, year = {2025}, doi = {10.3390/cells14060409}, pmid = {40136659}, url = {https://doi.org/10.3390/cells14060409} } @article{zedde2025-40299513, author = {Zedde, Marialuisa and Piazza, Fabrizio and Pascarella, Rosario}, title = {{Traumatic Brain Injury and Chronic Traumatic Encephalopathy: Not Only Trigger for Neurodegeneration but Also for Cerebral Amyloid Angiopathy?}}, journal = {Biomedicines}, year = {2025}, doi = {10.3390/biomedicines13040881}, pmid = {40299513}, url = {https://doi.org/10.3390/biomedicines13040881} } @article{choo2025-40561557, author = {Choo, Cameron Mavericks and Tan, Chin Hong}, title = {{Effects of regional white matter hyperintensities and β-amyloid on domain-specific cognition and progression to dementia}}, journal = {Brain and Cognition}, year = {2025}, doi = {10.1016/j.bandc.2025.106332}, pmid = {40561557}, url = {https://doi.org/10.1016/j.bandc.2025.106332} } @article{cao2025-39957423, author = {Cao, Le and Wang, Hang and Hao, Jinkui and Kwapong, William Robert and Xiong, Zhouwei and Wang, Ruilin and Ye, Chen and Zhao, Yitian and others}, title = {{Lower Retinal Arteriolar Density Is Associated With Higher Cerebral Small Vessel Disease Burden: An Optical Coherence Tomography Angiography Study}}, journal = {Brain and Behavior}, year = {2025}, doi = {10.1002/brb3.70342}, pmid = {39957423}, url = {https://doi.org/10.1002/brb3.70342} } @article{keller2025-41344663, author = {Keller, Jasmin Annica and Eiling, Ingmar and Hirschler, Lydiane and Václavů, Lena and Witjes‐Ané, Marie‐Noëlle W. and Wijngaarden, Marjolein A. and Nagtegaal, Martijn A. and Ercan, Ece and others}, title = {{The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study}}, journal = {JMIR Research Protocols}, year = {2025}, doi = {10.2196/77681}, pmid = {41344663}, url = {https://doi.org/10.2196/77681} } @article{reyes2025-41434809, author = {Reyes, Calvin D. and Gebre, Robel K and Gunter, Jeffrey L. and Hu, Mingzhao and Schwarz, Christopher G. and Meyer, Nolan K. and Reid, Robert I. and Kantarci, Kejal and others}, title = {{Harmonization Remains Unresolved: The Case of White Matter Hyperintensity Using ComBat And Deming Regression}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70861_108630}, pmid = {41434809}, url = {https://doi.org/10.1002/alz70861_108630} } @article{avan2025-40580987, author = {Avan, Abolfazl and Hachinski, Vladimir and Njamnshi, Wepnyu Yembe and Andersson, Neil and NJAMNSHI, Alfred Kongnyu}, title = {{The burden of stroke, ischaemic heart disease, and dementia in Africa, 1990–2021: an ecological analysis of the Global Burden of Disease 2021}}, journal = {The Lancet Global Health}, year = {2025}, doi = {10.1016/s2214-109x(25)00109-3}, pmid = {40580987}, url = {https://doi.org/10.1016/s2214-109x(25)00109-3} } @article{hong2025-40584208, author = {Hong, Yang and Feng, Min}, title = {{Severity and Prognosis of Vascular Dementia in Patients with Acute Cerebral Infarction Combined with H-Type Hypertension and Its Correlation with Uric Acid Levels}}, journal = {Neuropsychiatric Disease and Treatment}, year = {2025}, doi = {10.2147/ndt.s508965}, pmid = {40584208}, url = {https://doi.org/10.2147/ndt.s508965} } @article{zhao2025-40145977, author = {Zhao, Wenhui and Liu, Zhongxuan and Wu, Jiannan and Liu, Anran and Yan, Junqiang}, title = {{Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications}}, journal = {Neural Regeneration Research}, year = {2025}, doi = {10.4103/nrr.nrr-d-24-01343}, pmid = {40145977}, url = {https://doi.org/10.4103/nrr.nrr-d-24-01343} } @article{beretti2025-41595595, author = {Beretti, Francesca and Malenchini, Marta and Gatti, Martina and Maraldi, Tullia}, title = {{Oxidative Stress as a Central Mechanistic Bridge Between Alzheimer’s and Vascular Pathologies in Mixed Dementia: Emerging Evidence and Therapeutic Perspectives}}, journal = {Biomedicines}, year = {2025}, doi = {10.3390/biomedicines14010059}, pmid = {41595595}, url = {https://doi.org/10.3390/biomedicines14010059} } @article{harmouch2026-42215997, author = {Harmouch, Jamile and Green, Ryan J. and Mayilsamy, Karthick and Tosi, Kristina and Mohapatra, Subhra and Mohapatra, Shyam S.}, title = {{Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD}}, journal = {Journal of Neuroinflammation}, year = {2026}, doi = {10.1186/s12974-026-03876-2}, pmid = {42215997}, url = {https://doi.org/10.1186/s12974-026-03876-2} } @article{shukla2026-42123310, author = {Shukla, Manish and Li, Jarvis and Sun, Yan and Jin, Rong and Li, Guohong}, title = {{Microglial Plasticity in Vascular Dementia: Mechanisms and Therapeutic Reprogramming}}, journal = {International Journal of Molecular Sciences}, year = {2026}, doi = {10.3390/ijms27093719}, pmid = {42123310}, url = {https://doi.org/10.3390/ijms27093719} } @article{sun2025-40718100, author = {Sun, Kedi and Liu, Hui}, title = {{Emerging biomarkers and frontier therapies: unveiling the role of endothelial dysfunction in cerebral small vessel disease}}, journal = {Frontiers in Neurology}, year = {2025}, doi = {10.3389/fneur.2025.1615883}, pmid = {40718100}, url = {https://doi.org/10.3389/fneur.2025.1615883} } @article{kapoor2025-40034682, author = {Kapoor, Arunima and Dutt, Shubir and Nguyen, Amy and Lohman, Trevor and Gaubert, Aimée and Alitin, John Paul M and Sible, Isabel J. and Marshall, Anisa J. and others}, title = {{Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers}}, journal = {Cerebral Circulation - Cognition and Behavior}, year = {2025}, doi = {10.1016/j.cccb.2025.100378}, pmid = {40034682}, url = {https://doi.org/10.1016/j.cccb.2025.100378} } @article{sathyaseelan2025-40770913, author = {Sathyaseelan, Chakkarai and Le Grand, Quentin and Shaoxuan, Lucas Wang and Debette, Stéphanie and Sargurupremraj, Muralidharan}, title = {{Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke}}, journal = {Journal of Cerebral Blood Flow \& Metabolism}, year = {2025}, doi = {10.1177/0271678x251362977}, pmid = {40770913}, url = {https://doi.org/10.1177/0271678x251362977} } @article{gonzalezquevedo2025-b43f515c, author = {González‐Quevedo, Alina and Hernández, Tania Arrieta and Sánchez, Marisol Peña and Díaz, Zenaida Milagros Hernández and Arteche-Prior, Marianela and López, Javier Sánchez}, title = {{Incidental covert cerebral small vessel disease: Detection and management}}, journal = {Advanced Neurology}, year = {2025}, doi = {10.36922/an.4841}, url = {https://doi.org/10.36922/an.4841} }