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% Source: https://alzhub.org/research?access=free&atag=randomized
% 444 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{salloway2014-24450891,
  author  = {Salloway, S. and Sperling, R. and Fox, N. C. and Blennow, K. and Klunk, W. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others},
  title   = {{Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2014},
  doi     = {10.1056/nejmoa1304839},
  pmid    = {24450891},
  url     = {https://doi.org/10.1056/nejmoa1304839}
}

@article{zimmer2025-40063015,
  author  = {Zimmer, J. A. and Ardayfio, P. and Wang, H. and Khanna, R. and Evans, C. D. and Lu, M. and Sparks, J. and Andersen, S. and Lauzon, S. and Nery, E. S. M. and others},
  title   = {{Amyloid-Related Imaging Abnormalities With Donanemab in Early Symptomatic Alzheimer Disease: Secondary Analysis of the TRAILBLAZER-ALZ and ALZ 2 Randomized Clinical Trials}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.0065},
  pmid    = {40063015},
  url     = {https://doi.org/10.1001/jamaneurol.2025.0065}
}

@article{egan2019-30970186,
  author  = {Egan, M. F. and Kost, J. and Voss, T. and Mukai, Y. and Aisen, P. S. and Cummings, J. L. and Tariot, P. N. and Vellas, B. and others},
  title   = {{Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {2019},
  doi     = {10.1056/nejmoa1812840},
  pmid    = {30970186},
  url     = {https://doi.org/10.1056/nejmoa1812840}
}

@article{buddhaeberlein2022-35542991,
  author  = {Budd Haeberlein, S. and Aisen, P. S. and Barkhof, F. and Chalkias, S. and Chen, T. and Cohen, S. and Dent, G. and Hansson, O. and others},
  title   = {{Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2022},
  doi     = {10.14283/jpad.2022.30},
  pmid    = {35542991},
  url     = {https://doi.org/10.14283/jpad.2022.30}
}

@article{pontecorvo2022-36251300,
  author  = {Pontecorvo, M. J. and Lu, M. and Burnham, S. C. and Schade, A. E. and Dage, J. L. and Shcherbinin, S. and Collins, E. C. and Sims, JR. and others},
  title   = {{Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.3392},
  pmid    = {36251300},
  url     = {https://doi.org/10.1001/jamaneurol.2022.3392}
}

@article{dekosky2008-19017911,
  author  = {DeKosky, S. T. and Williamson, J. D. and Fitzpatrick, A. L. and Kronmal, R. A. and Ives, D. G. and Saxton, J. A. and Lopez, O. L. and Burke, G. and others},
  title   = {{Ginkgo biloba for prevention of dementia: a randomized controlled trial}},
  journal = {JAMA},
  year    = {2008},
  doi     = {10.1001/jama.2008.683},
  pmid    = {19017911},
  url     = {https://doi.org/10.1001/jama.2008.683}
}

@article{porsteinsson2014-24549548,
  author  = {Porsteinsson, A. P. and Drye, L. T. and Pollock, B. G. and Devanand, D. P. and Frangakis, C. and Ismail, Z. and Marano, C. and Meinert, C. L. and others},
  title   = {{Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial}},
  journal = {JAMA},
  year    = {2014},
  doi     = {10.1001/jama.2014.93},
  pmid    = {24549548},
  url     = {https://doi.org/10.1001/jama.2014.93}
}

@article{egan2018-29719179,
  author  = {Egan, M. F. and Kost, J. and Tariot, P. N. and Aisen, P. S. and Cummings, J. L. and Vellas, B. and Sur, C. and Mukai, Y. and others},
  title   = {{Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {2018},
  doi     = {10.1056/nejmoa1706441},
  pmid    = {29719179},
  url     = {https://doi.org/10.1056/nejmoa1706441}
}

@article{honig2018-29365294,
  author  = {Honig, L. S. and Vellas, B. and Woodward, M. and Boada, M. and Bullock, R. and Borrie, M. and Hager, K. and Andreasen, N. and others},
  title   = {{Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {2018},
  doi     = {10.1056/nejmoa1705971},
  pmid    = {29365294},
  url     = {https://doi.org/10.1056/nejmoa1705971}
}

@article{florian2023-36730056,
  author  = {Florian, H. and Wang, D. and Arnold, S. E. and Boada, M. and Guo, Q. and Jin, Z. and Zheng, H. and Fisseha, N. and others},
  title   = {{Tilavonemab in early Alzheimer's disease: results from a phase 2, randomized, double-blind study}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awad024},
  pmid    = {36730056},
  url     = {https://doi.org/10.1093/brain/awad024}
}

@article{turner2015-26362286,
  author  = {Turner, R. S. and Thomas, R. G. and Craft, S. and van Dyck, C. H. and Mintzer, J. and Reynolds, B. A. and Brewer, J. B. and Rissman, R. A. and others},
  title   = {{A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000002035},
  pmid    = {26362286},
  url     = {https://doi.org/10.1212/wnl.0000000000002035}
}

@article{ostrowitzki2022-36121669,
  author  = {Ostrowitzki, S. and Bittner, T. and Sink, K. M. and Mackey, H. and Rabe, C. and Honig, L. S. and Cassetta, E. and Woodward, M. and others},
  title   = {{Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.2909},
  pmid    = {36121669},
  url     = {https://doi.org/10.1001/jamaneurol.2022.2909}
}

@article{bateman2023-37966285,
  author  = {Bateman, R. J. and Smith, J. and Donohue, M. C. and Delmar, P. and Abbas, R. and Salloway, S. and Wojtowicz, J. and Blennow, K. and others},
  title   = {{Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {2023},
  doi     = {10.1056/nejmoa2304430},
  pmid    = {37966285},
  url     = {https://doi.org/10.1056/nejmoa2304430}
}

@article{swanson2021-33865446,
  author  = {Swanson, C. J. and Zhang, Y. and Dhadda, S. and Wang, J. and Kaplow, J. and Lai, R. Y. K. and Lannfelt, L. and Bradley, H. and others},
  title   = {{A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00813-8},
  pmid    = {33865446},
  url     = {https://doi.org/10.1186/s13195-021-00813-8}
}

@article{cummings2025-39780249,
  author  = {Cummings, J. L. and Atri, A. and Feldman, H. H. and Hansson, O. and Sano, M. and Knop, F. K. and Johannsen, P. and León, T. and others},
  title   = {{evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-024-01666-7},
  pmid    = {39780249},
  url     = {https://doi.org/10.1186/s13195-024-01666-7}
}

@article{quinn2010-21045096,
  author  = {Quinn, J. F. and Raman, R. and Thomas, R. G. and Yurko-Mauro, K. and Nelson, E. B. and Van Dyck, C. and Galvin, J. E. and Emond, J. and others},
  title   = {{Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial}},
  journal = {JAMA},
  year    = {2010},
  doi     = {10.1001/jama.2010.1510},
  pmid    = {21045096},
  url     = {https://doi.org/10.1001/jama.2010.1510}
}

@article{green2009-20009055,
  author  = {Green, R. C. and Schneider, L. S. and Amato, D. A. and Beelen, A. P. and Wilcock, G. and Swabb, E. A. and Zavitz, K. H. and {Tarenflurbil Phase 3 Study Group}},
  title   = {{Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial}},
  journal = {JAMA},
  year    = {2009},
  doi     = {10.1001/jama.2009.1866},
  pmid    = {20009055},
  url     = {https://doi.org/10.1001/jama.2009.1866}
}

@article{mcshane2019-30891742,
  author  = {McShane, R. and Westby, M. J. and Roberts, E. and Minakaran, N. and Schneider, L. and Farrimond, L. E. and Maayan, N. and Ware, J. and others},
  title   = {{Memantine for dementia}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2019},
  doi     = {10.1002/14651858.cd003154.pub6},
  pmid    = {30891742},
  url     = {https://doi.org/10.1002/14651858.cd003154.pub6}
}

@article{vandyck2023-36449413,
  author  = {van Dyck, C. H. and Swanson, C. J. and Aisen, P. and Bateman, R. J. and Chen, C. and Gee, M. and Kanekiyo, M. and Li, D. and others},
  title   = {{Lecanemab in Early Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {2023},
  doi     = {10.1056/nejmoa2212948},
  pmid    = {36449413},
  url     = {https://doi.org/10.1056/nejmoa2212948}
}

@article{dysken2014-24381967,
  author  = {Dysken, M. W. and Sano, M. and Asthana, S. and Vertrees, J. E. and Pallaki, M. and Llorente, M. and Love, S. and Schellenberg, G. D. and others},
  title   = {{Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial}},
  journal = {JAMA},
  year    = {2014},
  doi     = {10.1001/jama.2013.282834},
  pmid    = {24381967},
  url     = {https://doi.org/10.1001/jama.2013.282834}
}

@article{howard2020-31738372,
  author  = {Howard, R. and Zubko, O. and Bradley, R. and Harper, E. and Pank, L. and O'Brien, J. and Fox, C. and Tabet, N. and others},
  title   = {{Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2019.3762},
  pmid    = {31738372},
  url     = {https://doi.org/10.1001/jamaneurol.2019.3762}
}

@article{mintun2021-33720637,
  author  = {Mintun, M. A. and Lo, A. C. and Duggan Evans, C. and Wessels, A. M. and Ardayfio, P. A. and Andersen, S. W. and Shcherbinin, S. and Sparks, J. and others},
  title   = {{Donanemab in Early Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {2021},
  doi     = {10.1056/nejmoa2100708},
  pmid    = {33720637},
  url     = {https://doi.org/10.1056/nejmoa2100708}
}

@article{birks2018-29923184,
  author  = {Birks, J. S. and Harvey, R. J.},
  title   = {{Donepezil for dementia due to Alzheimer's disease}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2018},
  doi     = {10.1002/14651858.cd001190.pub3},
  pmid    = {29923184},
  url     = {https://doi.org/10.1002/14651858.cd001190.pub3}
}

@article{edison2025-41326666,
  author  = {Edison, P. and Femminella, G. D. and Ritchie, C. and Nowell, J. and Holmes, C. and Walker, Z. and Ridha, B. and Raza, S. and Livingston, N. R. and Frangou, E. and others},
  title   = {{Liraglutide in mild to moderate Alzheimer's disease: a phase 2b clinical trial}},
  journal = {Nature Medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-04106-7},
  pmid    = {41326666},
  url     = {https://doi.org/10.1038/s41591-025-04106-7}
}

@article{lamb2018-29769247,
  author  = {Lamb, S. E. and Sheehan, B. and Atherton, N. and Nichols, V. and Collins, H. and Mistry, D. and others},
  title   = {{Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial}},
  journal = {BMJ},
  year    = {2018},
  doi     = {10.1136/bmj.k1675},
  pmid    = {29769247},
  url     = {https://doi.org/10.1136/bmj.k1675}
}

@article{honig2024-38730496,
  author  = {Honig, L. S. and Sabbagh, M. N. and van Dyck, C. H. and Sperling, R. A. and Hersch, S. and Matta, A. and Giorgi, L. and Gee, M. and others},
  title   = {{Updated safety results from phase 3 lecanemab study in early Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01441-8},
  pmid    = {38730496},
  url     = {https://doi.org/10.1186/s13195-024-01441-8}
}

@article{aisen2008-18854539,
  author  = {Aisen, P. S. and Schneider, L. S. and Sano, M. and Diaz-Arrastia, R. and van Dyck, C. H. and Weiner, M. F. and Bottiglieri, T. and Jin, S. and others},
  title   = {{High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial}},
  journal = {JAMA},
  year    = {2008},
  doi     = {10.1001/jama.300.15.1774},
  pmid    = {18854539},
  url     = {https://doi.org/10.1001/jama.300.15.1774}
}

@article{wessels2020-31764959,
  author  = {Wessels, A. M. and Tariot, P. N. and Zimmer, J. A. and Selzler, K. J. and Bragg, S. M. and Andersen, S. W. and Landry, J. and Krull, J. H. and others},
  title   = {{Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2019.3988},
  pmid    = {31764959},
  url     = {https://doi.org/10.1001/jamaneurol.2019.3988}
}

@article{teng2022-35696185,
  author  = {Teng, E. and Manser, P. T. and Pickthorn, K. and Brunstein, F. and Blendstrup, M. and Sanabria Bohorquez, S. and Wildsmith, K. R. and Toth, B. and others},
  title   = {{Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.1375},
  pmid    = {35696185},
  url     = {https://doi.org/10.1001/jamaneurol.2022.1375}
}

@article{ryan2020-32213642,
  author  = {Ryan, J. and Storey, E. and Murray, A. M. and Woods, R. L. and Wolfe, R. and Reid, C. M. and Nelson, M. R. and Chong, T. T. J. and others},
  title   = {{Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline}},
  journal = {Neurology},
  year    = {2020},
  doi     = {10.1212/wnl.0000000000009277},
  pmid    = {32213642},
  url     = {https://doi.org/10.1212/wnl.0000000000009277}
}

@article{atri2018-29318278,
  author  = {Atri, A. and Frölich, L. and Ballard, C. and Tariot, P. N. and Molinuevo, J. L. and Boneva, N. and Windfeld, K. and Raket, L. L. and others},
  title   = {{Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials}},
  journal = {JAMA},
  year    = {2018},
  doi     = {10.1001/jama.2017.20373},
  pmid    = {29318278},
  url     = {https://doi.org/10.1001/jama.2017.20373}
}

@article{ayton2025-39495531,
  author  = {Ayton, S. and Barton, D. and Brew, B. and Brodtmann, A. and Clarnette, R. and Desmond, P. and Devos, D. and Ellis, K. A. and others},
  title   = {{Deferiprone in Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2024.3733},
  pmid    = {39495531},
  url     = {https://doi.org/10.1001/jamaneurol.2024.3733}
}

@article{emre2004-15590953,
  author  = {Emre, M. and Aarsland, D. and Albanese, A. and Byrne, E. J. and Deuschl, G. and De Deyn, P. P. and Durif, F. and Kulisevsky, J. and others},
  title   = {{Rivastigmine for dementia associated with Parkinson's disease}},
  journal = {The New England journal of medicine},
  year    = {2004},
  doi     = {10.1056/nejmoa041470},
  pmid    = {15590953},
  url     = {https://doi.org/10.1056/nejmoa041470}
}

@article{ostrowitzki2017-29221491,
  author  = {Ostrowitzki, S. and Lasser, R. A. and Dorflinger, E. and Scheltens, P. and Barkhof, F. and Nikolcheva, T. and Ashford, E. and Retout, S. and others},
  title   = {{A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0318-y},
  pmid    = {29221491},
  url     = {https://doi.org/10.1186/s13195-017-0318-y}
}

@article{craft2020-32568367,
  author  = {Craft, S. and Raman, R. and Chow, T. W. and Rafii, M. S. and Sun, C. K. and Rissman, R. A. and Donohue, M. C. and Brewer, J. B. and others},
  title   = {{Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.1840},
  pmid    = {32568367},
  url     = {https://doi.org/10.1001/jamaneurol.2020.1840}
}

@article{salloway2025-39556389,
  author  = {Salloway, S. and Wojtowicz, J. and Voyle, N. and Lane, C. A. and Klein, G. and Lyons, M. and Rossomanno, S. and Mazzo, F. and others},
  title   = {{Amyloid-Related Imaging Abnormalities (ARIA) in Clinical Trials of Gantenerumab in Early Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2024.3937},
  pmid    = {39556389},
  url     = {https://doi.org/10.1001/jamaneurol.2024.3937}
}

@article{tzourio2003-12742805,
  author  = {Tzourio, C. and Anderson, C. and Chapman, N. and Woodward, M. and Neal, B. and MacMahon, S. and Chalmers, J. and {PROGRESS Collaborative Group}},
  title   = {{Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease}},
  journal = {Archives of internal medicine},
  year    = {2003},
  doi     = {10.1001/archinte.163.9.1069},
  pmid    = {12742805},
  url     = {https://doi.org/10.1001/archinte.163.9.1069}
}

@article{battle2021-33704781,
  author  = {Battle, C. E. and Abdul-Rahim, A. H. and Shenkin, S. D. and Hewitt, J. and Quinn, T. J.},
  title   = {{Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta-analysis}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2021},
  doi     = {10.1002/14651858.cd013306.pub2},
  pmid    = {33704781},
  url     = {https://doi.org/10.1002/14651858.cd013306.pub2}
}

@article{wang2025-40172303,
  author  = {Wang, H. and Serap Monkul Nery, E. and Ardayfio, P. and Khanna, R. and Otero Svaldi, D. and Gueorguieva, I. and Shcherbinin, S. and Andersen, S. W. and Hauck, P. M. and Engle, S. E. and others},
  title   = {{Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction}},
  journal = {Alzheimer's \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70062},
  pmid    = {40172303},
  url     = {https://doi.org/10.1002/alz.70062}
}

@article{nonino2026-41985900,
  author  = {Nonino, F. and Minozzi, S. and Sambati, L. and Del Giovane, C. and Baldin, E. and Bassi, M. C. and others},
  title   = {{Amyloid-beta-targeting monoclonal antibodies for people with mild cognitive impairment or mild dementia due to Alzheimer's disease (Cochrane review)}},
  journal = {Cochrane Database of Systematic Reviews},
  year    = {2026},
  doi     = {10.1002/14651858.CD016297},
  pmid    = {41985900},
  url     = {https://doi.org/10.1002/14651858.CD016297}
}

@article{lu2025-41082199,
  author  = {Lu, M. and Kim, M. J. and Collins, E. C. and Shcherbinin, S. and Ellinwood, A. K. and Yokoi, Y. and Brooks, D. A. and Hansson, O. and others},
  title   = {{Posttreatment Amyloid Levels and Clinical Outcomes Following Donanemab for Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ 2 Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.3869},
  pmid    = {41082199},
  url     = {https://doi.org/10.1001/jamaneurol.2025.3869}
}

@article{shanks2024-38760589,
  author  = {Shanks, H. R. C. and Chen, K. and Reiman, E. M. and Blennow, K. and Cummings, J. L. and Massa, S. M. and Longo, F. M. and Börjesson-Hanson, A. and others},
  title   = {{p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial}},
  journal = {Nature medicine},
  year    = {2024},
  doi     = {10.1038/s41591-024-02977-w},
  pmid    = {38760589},
  url     = {https://doi.org/10.1038/s41591-024-02977-w}
}

@article{adesuyan2024-38324745,
  author  = {Adesuyan, M. and Jani, Y. H. and Alsugeir, D. and Howard, R. and Ju, C. and Wei, L. and Brauer, R.},
  title   = {{Phosphodiesterase Type 5 Inhibitors in Men With Erectile Dysfunction and the Risk of Alzheimer Disease: A Cohort Study}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000209131},
  pmid    = {38324745},
  url     = {https://doi.org/10.1212/wnl.0000000000209131}
}

@article{dubois2023-36849969,
  author  = {Dubois, B. and López-Arrieta, J. and Lipschitz, S. and Doskas, T. and Spiru, L. and Moroz, S. and Venger, O. and Vermersch, P. and others},
  title   = {{Masitinib for mild-to-moderate Alzheimer's disease: results from a randomized, placebo-controlled, phase 3, clinical trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2023},
  doi     = {10.1186/s13195-023-01169-x},
  pmid    = {36849969},
  url     = {https://doi.org/10.1186/s13195-023-01169-x}
}

@article{forette2002-12374512,
  author  = {Forette, F. and Seux, M. L. and Staessen, J. A. and Thijs, L. and Babarskiene, M. R. and Babeanu, S. and Bossini, A. and Fagard, R. and others},
  title   = {{The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study}},
  journal = {Archives of internal medicine},
  year    = {2002},
  doi     = {10.1001/archinte.162.18.2046},
  pmid    = {12374512},
  url     = {https://doi.org/10.1001/archinte.162.18.2046}
}

@article{teri2003-14559955,
  author  = {Teri, L. and Gibbons, L. E. and McCurry, S. M. and Logsdon, R. G. and Buchner, D. M. and Barlow, W. E. and Kukull, W. A. and LaCroix, A. Z. and others},
  title   = {{Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial}},
  journal = {JAMA},
  year    = {2003},
  doi     = {10.1001/jama.290.15.2015},
  pmid    = {14559955},
  url     = {https://doi.org/10.1001/jama.290.15.2015}
}

@article{sano2011-21795660,
  author  = {Sano, M. and Bell, K. L. and Galasko, D. and Galvin, J. E. and Thomas, R. G. and van Dyck, C. H. and Aisen, P. S.},
  title   = {{A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e318228bf11},
  pmid    = {21795660},
  url     = {https://doi.org/10.1212/wnl.0b013e318228bf11}
}

@article{rajji2025-40133524,
  author  = {Rajji, T. K. and Baksh, S. N. and Shade, D. M. and Ismail, Z. and Burhan, A. M. and Okhravi, H. R. and Padala, P. R. and Rosenberg, P. B. and Schneider, L. S. and Porsteinsson, A. P. and others},
  title   = {{Escitalopram for agitation in Alzheimer's dementia: a randomized controlled phase 3 trial}},
  journal = {Nature Medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03569-y},
  pmid    = {40133524},
  url     = {https://doi.org/10.1038/s41591-025-03569-y}
}

@article{ebell2024-38253509,
  author  = {Ebell, M. H. and Barry, H. C. and Baduni, K. and Grasso, G.},
  title   = {{Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis}},
  journal = {Annals of Family Medicine},
  year    = {2024},
  doi     = {10.1370/afm.3050},
  pmid    = {38253509},
  url     = {https://doi.org/10.1370/afm.3050}
}

@article{wagemann2024-38683602,
  author  = {Wagemann, O. and Liu, H. and Wang, G. and Shi, X. and Bittner, T. and Scelsi, M. A. and Farlow, M. R. and Clifford, D. B. and others},
  title   = {{Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2024},
  doi     = {10.1001/jamaneurol.2024.0991},
  pmid    = {38683602},
  url     = {https://doi.org/10.1001/jamaneurol.2024.0991}
}

@article{salloway2009-19923550,
  author  = {Salloway, S. and Sperling, R. and Gilman, S. and Fox, N. C. and Blennow, K. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others},
  title   = {{A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181c67808},
  pmid    = {19923550},
  url     = {https://doi.org/10.1212/wnl.0b013e3181c67808}
}

@article{sims2023-37459141,
  author  = {Sims, JR. and Zimmer, J. A. and Evans, C. D. and Lu, M. and Ardayfio, P. and Sparks, J. and Wessels, A. M. and Shcherbinin, S. and others},
  title   = {{Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial}},
  journal = {JAMA},
  year    = {2023},
  doi     = {10.1001/jama.2023.13239},
  pmid    = {37459141},
  url     = {https://doi.org/10.1001/jama.2023.13239}
}

@article{craft2012-21911655,
  author  = {Craft, S. and Baker, L. D. and Montine, T. J. and Minoshima, S. and Watson, G. S. and Claxton, A. and Arbuckle, M. and Callaghan, M. and others},
  title   = {{Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial}},
  journal = {Archives of neurology},
  year    = {2012},
  doi     = {10.1001/archneurol.2011.233},
  pmid    = {21911655},
  url     = {https://doi.org/10.1001/archneurol.2011.233}
}

@article{vossel2021-34570177,
  author  = {Vossel, K. and Ranasinghe, K. G. and Beagle, A. J. and La, A. and Ah Pook, K. and Castro, M. and Mizuiri, D. and Honma, S. M. and others},
  title   = {{Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2021},
  doi     = {10.1001/jamaneurol.2021.3310},
  pmid    = {34570177},
  url     = {https://doi.org/10.1001/jamaneurol.2021.3310}
}

@article{aisen2011-22291741,
  author  = {Aisen, P. S. and Gauthier, S. and Ferris, S. H. and Saumier, D. and Haine, D. and Garceau, D. and Duong, A. and Suhy, J. and others},
  title   = {{Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)}},
  journal = {Archives of medical science : AMS},
  year    = {2011},
  doi     = {10.5114/aoms.2011.20612},
  pmid    = {22291741},
  url     = {https://doi.org/10.5114/aoms.2011.20612}
}

@article{cummings2018-29695589,
  author  = {Cummings, J. L. and Cohen, S. and van Dyck, C. H. and Brody, M. and Curtis, C. and Cho, W. and Ward, M. and Friesenhahn, M. and others},
  title   = {{ABBY: A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000005550},
  pmid    = {29695589},
  url     = {https://doi.org/10.1212/wnl.0000000000005550}
}

@article{coric2015-26414022,
  author  = {Coric, V. and Salloway, S. and van Dyck, C. H. and Dubois, B. and Andreasen, N. and Brody, M. and Curtis, C. and Soininen, H. and others},
  title   = {{Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2015.0607},
  pmid    = {26414022},
  url     = {https://doi.org/10.1001/jamaneurol.2015.0607}
}

@article{meyer2019-30952794,
  author  = {Meyer, P. F. and Tremblay-Mercier, J. and Leoutsakos, J. and Madjar, C. and Lafaille-Magnan, M. E. and Savard, M. and Rosa-Neto, P. and Poirier, J. and others},
  title   = {{INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease}},
  journal = {Neurology},
  year    = {2019},
  doi     = {10.1212/wnl.0000000000007232},
  pmid    = {30952794},
  url     = {https://doi.org/10.1212/wnl.0000000000007232}
}

@article{monteiro2023-37643887,
  author  = {Monteiro, C. and Toth, B. and Brunstein, F. and Bobbala, A. and Datta, S. and Ceniceros, R. and Sanabria Bohorquez, S. M. and Anania, V. G. and others},
  title   = {{Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet}},
  journal = {Neurology},
  year    = {2023},
  doi     = {10.1212/wnl.0000000000207663},
  pmid    = {37643887},
  url     = {https://doi.org/10.1212/wnl.0000000000207663}
}

@article{xiao2021-33731209,
  author  = {Xiao, S. and Chan, P. and Wang, T. and Hong, Z. and Wang, S. and Kuang, W. and He, J. and Pan, X. and others},
  title   = {{A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00795-7},
  pmid    = {33731209},
  url     = {https://doi.org/10.1186/s13195-021-00795-7}
}

@article{kryscio2017-28319243,
  author  = {Kryscio, R. J. and Abner, E. L. and Caban-Holt, A. and Lovell, M. and Goodman, P. and Darke, A. K. and Yee, M. and Crowley, J. and others},
  title   = {{Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE)}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.5778},
  pmid    = {28319243},
  url     = {https://doi.org/10.1001/jamaneurol.2016.5778}
}

@article{douaud2013-23690582,
  author  = {Douaud, G. and Refsum, H. and de Jager, C. A. and Jacoby, R. and Nichols, T. E. and Smith, S. M. and Smith, A. D.},
  title   = {{Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2013},
  doi     = {10.1073/pnas.1301816110},
  pmid    = {23690582},
  url     = {https://doi.org/10.1073/pnas.1301816110}
}

@article{rolinski2012-22419314,
  author  = {Rolinski, M. and Fox, C. and Maidment, I. and McShane, R.},
  title   = {{Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2012},
  doi     = {10.1002/14651858.cd006504.pub2},
  pmid    = {22419314},
  url     = {https://doi.org/10.1002/14651858.cd006504.pub2}
}

@article{lawlor2018-30248105,
  author  = {Lawlor, B. and Segurado, R. and Kennelly, S. and Olde Rikkert, M. G. M. and Howard, R. and Pasquier, F. and Börjesson-Hanson, A. and Tsolaki, M. and others},
  title   = {{Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial}},
  journal = {PLoS medicine},
  year    = {2018},
  doi     = {10.1371/journal.pmed.1002660},
  pmid    = {30248105},
  url     = {https://doi.org/10.1371/journal.pmed.1002660}
}

@article{prins2021-34044875,
  author  = {Prins, N. D. and Harrison, J. E. and Chu, H. M. and Blackburn, K. and Alam, J. J. and Scheltens, P. and {REVERSE-SD Study Investigators}},
  title   = {{A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00843-2},
  pmid    = {34044875},
  url     = {https://doi.org/10.1186/s13195-021-00843-2}
}

@article{breitner2011-21784351,
  author  = {Breitner, J. C. and Baker, L. D. and Montine, T. J. and Meinert, C. L. and Lyketsos, C. G. and Ashe, K. H. and Brandt, J. and Craft, S. and others},
  title   = {{Extended results of the Alzheimer's disease anti-inflammatory prevention trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2011},
  doi     = {10.1016/j.jalz.2010.12.014},
  pmid    = {21784351},
  url     = {https://doi.org/10.1016/j.jalz.2010.12.014}
}

@article{chew2015-26305649,
  author  = {Chew, E. Y. and Clemons, T. E. and Agrón, E. and Launer, L. J. and Grodstein, F. and Bernstein, P. S.},
  title   = {{Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial}},
  journal = {JAMA},
  year    = {2015},
  doi     = {10.1001/jama.2015.9677},
  pmid    = {26305649},
  url     = {https://doi.org/10.1001/jama.2015.9677}
}

@article{sperling2021-33464300,
  author  = {Sperling, R. and Henley, D. and Aisen, P. S. and Raman, R. and Donohue, M. C. and Ernstrom, K. and Rafii, M. S. and Streffer, J. and others},
  title   = {{Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2021},
  doi     = {10.1001/jamaneurol.2020.4857},
  pmid    = {33464300},
  url     = {https://doi.org/10.1001/jamaneurol.2020.4857}
}

@article{mintzer2021-34570180,
  author  = {Mintzer, J. and Lanctôt, K. L. and Scherer, R. W. and Rosenberg, P. B. and Herrmann, N. and van Dyck, C. H. and Padala, P. R. and Brawman-Mintzer, O. and others},
  title   = {{Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2021},
  doi     = {10.1001/jamaneurol.2021.3356},
  pmid    = {34570180},
  url     = {https://doi.org/10.1001/jamaneurol.2021.3356}
}

@article{truong2022-36096687,
  author  = {Truong, C. and Recto, C. and Lafont, C. and Canoui-Poitrine, F. and Belmin, J. B. and Lafuente-Lafuente, C.},
  title   = {{Effect of Cholinesterase Inhibitors on Mortality in Patients With Dementia: A Systematic Review of Randomized and Nonrandomized Trials}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000201161},
  pmid    = {36096687},
  url     = {https://doi.org/10.1212/wnl.0000000000201161}
}

@article{devanand2026-41405855,
  author  = {Devanand, D P and Wisniewski, Thomas and Razlighi, Qolamreza and Qian, Min and Wei, Renjie and Andrews, Howard F and Acosta, Edward P and Bell, Karen L and others},
  title   = {{Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial}},
  journal = {JAMA},
  year    = {2026},
  doi     = {10.1001/jama.2025.21738},
  pmid    = {41405855},
  url     = {https://doi.org/10.1001/jama.2025.21738}
}

@article{fleisher2024-38386949,
  author  = {Fleisher, A. S. and Munsie, L. M. and Perahia, D. G. S. and Andersen, S. W. and Higgins, I. A. and Hauck, P. M. and Lo, A. C. and Sims, JR. and others},
  title   = {{Assessment of Efficacy and Safety of Zagotenemab: Results From PERISCOPE-ALZ, a Phase 2 Study in Early Symptomatic Alzheimer Disease}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000208061},
  pmid    = {38386949},
  url     = {https://doi.org/10.1212/wnl.0000000000208061}
}

@article{fleisher2011-21917762,
  author  = {Fleisher, A. S. and Truran, D. and Mai, J. T. and Langbaum, J. B. and Aisen, P. S. and Cummings, J. L. and Jack, C. R. and Weiner, M. W. and others},
  title   = {{Chronic divalproex sodium use and brain atrophy in Alzheimer disease}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e318230a16c},
  pmid    = {21917762},
  url     = {https://doi.org/10.1212/wnl.0b013e318230a16c}
}

@article{butchart2015-25934853,
  author  = {Butchart, J. and Brook, L. and Hopkins, V. and Teeling, J. and Püntener, U. and Culliford, D. and Sharples, R. and Sharif, S. and others},
  title   = {{Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000001617},
  pmid    = {25934853},
  url     = {https://doi.org/10.1212/wnl.0000000000001617}
}

@article{sha2019-30383097,
  author  = {Sha, S. J. and Deutsch, G. K. and Tian, L. and Richardson, K. and Coburn, M. and Gaudioso, J. L. and Marcal, T. and Solomon, E. and others},
  title   = {{Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2018.3288},
  pmid    = {30383097},
  url     = {https://doi.org/10.1001/jamaneurol.2018.3288}
}

@article{mori2012-22829268,
  author  = {Mori, E. and Ikeda, M. and Kosaka, K. and {Donepezil-DLB Study Investigators}},
  title   = {{Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial}},
  journal = {Annals of neurology},
  year    = {2012},
  doi     = {10.1002/ana.23557},
  pmid    = {22829268},
  url     = {https://doi.org/10.1002/ana.23557}
}

@article{russ2012-22972133,
  author  = {Russ, T. C. and Morling, JR.},
  title   = {{Cholinesterase inhibitors for mild cognitive impairment}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2012},
  doi     = {10.1002/14651858.cd009132.pub2},
  pmid    = {22972133},
  url     = {https://doi.org/10.1002/14651858.cd009132.pub2}
}

@article{birks2006-16437532,
  author  = {Birks, J.},
  title   = {{Cholinesterase inhibitors for Alzheimer's disease}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2006},
  doi     = {10.1002/14651858.cd005593},
  pmid    = {16437532},
  url     = {https://doi.org/10.1002/14651858.cd005593}
}

@article{loy2006-16437436,
  author  = {Loy, C. and Schneider, L.},
  title   = {{Galantamine for Alzheimer's disease and mild cognitive impairment}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2006},
  doi     = {10.1002/14651858.cd001747.pub3},
  pmid    = {16437436},
  url     = {https://doi.org/10.1002/14651858.cd001747.pub3}
}

@article{cummings2026-41865758,
  author  = {Cummings, Jeffrey L and Atri, Alireza and Sano, Mary and Zetterberg, Henrik and Scheltens, Philip and Knop, Filip K and Johannsen, Peter and Wichmann, Christian Ahmad and others},
  title   = {{Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials}},
  journal = {The Lancet},
  year    = {2026},
  doi     = {10.1016/s0140-6736(26)00459-9},
  pmid    = {41865758},
  url     = {https://doi.org/10.1016/s0140-6736(26)00459-9}
}

@article{paczynski2025-40354064,
  author  = {Paczynski, M. and Hofmann, A. and Posey, Z. and Gregersen, M. and Rudman, M. and Ellington, D. and Aldinger, M. and Musiek, E. S. and Holtzman, D. M. and Bateman, R. J. and others},
  title   = {{Lecanemab Treatment in a Specialty Memory Clinic}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.1232},
  pmid    = {40354064},
  url     = {https://doi.org/10.1001/jamaneurol.2025.1232}
}

@article{shinto2014-24077434,
  author  = {Shinto, L. and Quinn, J. and Montine, T. and Dodge, H. H. and Woodward, W. and Baldauf-Wagner, S. and Waichunas, D. and Bumgarner, L. and others},
  title   = {{A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-130722},
  pmid    = {24077434},
  url     = {https://doi.org/10.3233/jad-130722}
}

@article{rosenberg2010-20087081,
  author  = {Rosenberg, P. B. and Drye, L. T. and Martin, B. K. and Frangakis, C. and Mintzer, J. E. and Weintraub, D. and Porsteinsson, A. P. and Schneider, L. S. and others},
  title   = {{Sertraline for the treatment of depression in Alzheimer disease}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2010},
  doi     = {10.1097/jgp.0b013e3181c796eb},
  pmid    = {20087081},
  url     = {https://doi.org/10.1097/jgp.0b013e3181c796eb}
}

@article{tariot2011-21810649,
  author  = {Tariot, P. N. and Schneider, L. S. and Cummings, J. and Thomas, R. G. and Raman, R. and Jakimovich, L. J. and Loy, R. and Bartocci, B. and others},
  title   = {{Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease}},
  journal = {Archives of general psychiatry},
  year    = {2011},
  doi     = {10.1001/archgenpsychiatry.2011.72},
  pmid    = {21810649},
  url     = {https://doi.org/10.1001/archgenpsychiatry.2011.72}
}

@article{jung2024-38709534,
  author  = {Jung, Y. H. and Jang, H. and Park, S. and Kim, H. J. and Seo, S. W. and Kim, G. B. and Shon, Y. M. and Kim, S. and others},
  title   = {{Effectiveness of Personalized Hippocampal Network-Targeted Stimulation in Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2024},
  doi     = {10.1001/jamanetworkopen.2024.9220},
  pmid    = {38709534},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.9220}
}

@article{maier2020-32463470,
  author  = {Maier, F. and Spottke, A. and Bach, J. P. and Bartels, C. and Buerger, K. and Dodel, R. and Fellgiebel, A. and Fliessbach, K. and others},
  title   = {{Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2020},
  doi     = {10.1001/jamanetworkopen.2020.6027},
  pmid    = {32463470},
  url     = {https://doi.org/10.1001/jamanetworkopen.2020.6027}
}

@article{marjoribanks2017-28093732,
  author  = {Marjoribanks, J. and Farquhar, C. and Roberts, H. and Lethaby, A. and Lee, J.},
  title   = {{Long-term hormone therapy for perimenopausal and postmenopausal women}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2017},
  doi     = {10.1002/14651858.cd004143.pub5},
  pmid    = {28093732},
  url     = {https://doi.org/10.1002/14651858.cd004143.pub5}
}

@article{curtis2015-25622185,
  author  = {Curtis, C. and Gamez, J. E. and Singh, U. and Sadowsky, C. H. and Villena, T. and Sabbagh, M. N. and Beach, T. G. and Duara, R. and others},
  title   = {{Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 imaging and neuritic plaque density}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.4144},
  pmid    = {25622185},
  url     = {https://doi.org/10.1001/jamaneurol.2014.4144}
}

@article{blackman2021-33289311,
  author  = {Blackman, J. and Swirski, M. and Clynes, J. and Harding, S. and Leng, Y. and Coulthard, E.},
  title   = {{Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review}},
  journal = {Journal of sleep research},
  year    = {2021},
  doi     = {10.1111/jsr.13229},
  pmid    = {33289311},
  url     = {https://doi.org/10.1111/jsr.13229}
}

@article{lozano2016-27567810,
  author  = {Lozano, A. M. and Fosdick, L. and Chakravarty, M. M. and Leoutsakos, J. M. and Munro, C. and Oh, E. and Drake, K. E. and Lyman, C. H. and others},
  title   = {{A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2016},
  doi     = {10.3233/jad-160017},
  pmid    = {27567810},
  url     = {https://doi.org/10.3233/jad-160017}
}

@article{sevigny2024-38745011,
  author  = {Sevigny, J. and Uspenskaya, O. and Heckman, L. D. and Wong, L. C. and Hatch, D. A. and Tewari, A. and Vandenberghe, R. and Irwin, D. J. and others},
  title   = {{Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results}},
  journal = {Nature medicine},
  year    = {2024},
  doi     = {10.1038/s41591-024-02973-0},
  pmid    = {38745011},
  url     = {https://doi.org/10.1038/s41591-024-02973-0}
}

@article{wieland2026-41641880,
  author  = {Wieland, Lisa S and Ludeman, Emilie and Chi, Yuan and Feinberg, Termeh M and Chen, I-Hui and Chen, Kee-Hsin and Zhu, Yanan and Wolverson, Emma and others},
  title   = {{Ginkgo biloba for cognitive impairment and dementia}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2026},
  doi     = {10.1002/14651858.CD013661.pub2},
  pmid    = {41641880},
  url     = {https://doi.org/10.1002/14651858.CD013661.pub2}
}

@article{cantoni2025-41359335,
  author  = {Cantoni, V. and Casula, E. P. and Tarantino, B. and Cupidi, C. and Huber, N. and Altomare, D. and Premi, E. and Zummo, E. and others},
  title   = {{Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2025},
  doi     = {10.1001/jamanetworkopen.2025.46556},
  pmid    = {41359335},
  url     = {https://doi.org/10.1001/jamanetworkopen.2025.46556}
}

@article{ooms2014-24887018,
  author  = {Ooms, S. and Overeem, S. and Besse, K. and Rikkert, M. O. and Verbeek, M. and Claassen, J. A.},
  title   = {{Effect of 1 night of total sleep deprivation on cerebrospinal fluid β-amyloid 42 in healthy middle-aged men: a randomized clinical trial}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1173},
  pmid    = {24887018},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1173}
}

@article{shinto2024-39088212,
  author  = {Shinto, L. H. and Murchison, C. F. and Silbert, L. C. and Dodge, H. H. and Lahna, D. and Rooney, W. and Kaye, J. and Quinn, J. F. and others},
  title   = {{ω-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults: A Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2024},
  doi     = {10.1001/jamanetworkopen.2024.26872},
  pmid    = {39088212},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.26872}
}

@article{phillips2021-33622392,
  author  = {Phillips, M. C. L. and Deprez, L. M. and Mortimer, G. M. N. and Murtagh, D. K. J. and McCoy, S. and Mylchreest, R. and Gilbertson, L. J. and Clark, K. M. and others},
  title   = {{Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00783-x},
  pmid    = {33622392},
  url     = {https://doi.org/10.1186/s13195-021-00783-x}
}

@article{berk2020-32492080,
  author  = {Berk, M. and Woods, R. L. and Nelson, M. R. and Shah, R. C. and Reid, C. M. and Storey, E. and Fitzgerald, S. and Lockery, J. E. and others},
  title   = {{Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial}},
  journal = {JAMA psychiatry},
  year    = {2020},
  doi     = {10.1001/jamapsychiatry.2020.1214},
  pmid    = {32492080},
  url     = {https://doi.org/10.1001/jamapsychiatry.2020.1214}
}

@article{reynolds2011-21199965,
  author  = {Reynolds, C. F. and Butters, M. A. and Lopez, O. and Pollock, B. G. and Dew, M. A. and Mulsant, B. H. and Lenze, E. J. and Holm, M. and others},
  title   = {{Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy}},
  journal = {Archives of general psychiatry},
  year    = {2011},
  doi     = {10.1001/archgenpsychiatry.2010.184},
  pmid    = {21199965},
  url     = {https://doi.org/10.1001/archgenpsychiatry.2010.184}
}

@article{study2008-18474729,
  author  = {{ADAPT Research Group} and Martin, B. K. and Szekely, C. and Brandt, J. and Piantadosi, S. and Breitner, J. C. and Craft, S. and Evans, D. and others},
  title   = {{Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.2008.65.7.nct70006},
  pmid    = {18474729},
  url     = {https://doi.org/10.1001/archneur.2008.65.7.nct70006}
}

@article{fleisher2008-18695053,
  author  = {Fleisher, A. S. and Raman, R. and Siemers, E. R. and Becerra, L. and Clark, C. M. and Dean, R. A. and Farlow, M. R. and Galvin, J. E. and others},
  title   = {{Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.8.1031},
  pmid    = {18695053},
  url     = {https://doi.org/10.1001/archneur.65.8.1031}
}

@article{salloway2011-21917766,
  author  = {Salloway, S. and Sperling, R. and Keren, R. and Porsteinsson, A. P. and van Dyck, C. H. and Tariot, P. N. and Gilman, S. and Arnold, D. and others},
  title   = {{A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e3182309fa5},
  pmid    = {21917766},
  url     = {https://doi.org/10.1212/wnl.0b013e3182309fa5}
}

@article{galasko2014-24696507,
  author  = {Galasko, D. and Bell, J. and Mancuso, J. Y. and Kupiec, J. W. and Sabbagh, M. N. and van Dyck, C. and Thomas, R. G. and Aisen, P. S. and others},
  title   = {{Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000364},
  pmid    = {24696507},
  url     = {https://doi.org/10.1212/wnl.0000000000000364}
}

@article{rafii2011-21502597,
  author  = {Rafii, M. S. and Walsh, S. and Little, J. T. and Behan, K. and Reynolds, B. and Ward, C. and Jin, S. and Thomas, R. and others},
  title   = {{A phase II trial of huperzine A in mild to moderate Alzheimer disease}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e318216eb7b},
  pmid    = {21502597},
  url     = {https://doi.org/10.1212/wnl.0b013e318216eb7b}
}

@article{williamson2007-17599421,
  author  = {Williamson, J. D. and Miller, M. E. and Bryan, R. N. and Lazar, R. M. and Coker, L. H. and Johnson, J. and Cukierman, T. and Horowitz, K. R. and others},
  title   = {{The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods}},
  journal = {The American journal of cardiology},
  year    = {2007},
  doi     = {10.1016/j.amjcard.2007.03.029},
  pmid    = {17599421},
  url     = {https://doi.org/10.1016/j.amjcard.2007.03.029}
}

@article{schneider2019-31492718,
  author  = {Schneider, L. S. and Geffen, Y. and Rabinowitz, J. and Thomas, R. G. and Schmidt, R. and Ropele, S. and Weinstock, M. and {Ladostigil Study Group}},
  title   = {{Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial}},
  journal = {Neurology},
  year    = {2019},
  doi     = {10.1212/wnl.0000000000008239},
  pmid    = {31492718},
  url     = {https://doi.org/10.1212/wnl.0000000000008239}
}

@article{rolland2019-31426362,
  author  = {Rolland, Y. and Barreto, P. S. and Maltais, M. and Guyonnet, S. and Cantet, C. and Andrieu, S. and Vellas, B.},
  title   = {{Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT)}},
  journal = {Nutrients},
  year    = {2019},
  doi     = {10.3390/nu11081931},
  pmid    = {31426362},
  url     = {https://doi.org/10.3390/nu11081931}
}

@article{watt2020-32546202,
  author  = {Watt, J. A. and Goodarzi, Z. and Veroniki, A. A. and Nincic, V. and Khan, P. A. and Ghassemi, M. and Thompson, Y. and Lai, Y. and others},
  title   = {{Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysis}},
  journal = {BMC geriatrics},
  year    = {2020},
  doi     = {10.1186/s12877-020-01607-7},
  pmid    = {32546202},
  url     = {https://doi.org/10.1186/s12877-020-01607-7}
}

@article{marcum2023-36598787,
  author  = {Marcum, Z. A. and Gabriel, N. and Bress, A. P. and Hernandez, I.},
  title   = {{Association of New Use of Antihypertensives That Stimulate vs Inhibit Type 2 and 4 Angiotensin II Receptors With Dementia Among Medicare Beneficiaries}},
  journal = {JAMA network open},
  year    = {2023},
  doi     = {10.1001/jamanetworkopen.2022.49370},
  pmid    = {36598787},
  url     = {https://doi.org/10.1001/jamanetworkopen.2022.49370}
}

@article{saito2023-38048134,
  author  = {Saito, S. and Suzuki, K. and Ohtani, R. and Maki, T. and Kowa, H. and Tachibana, H. and Washida, K. and Kawabata, N. and others},
  title   = {{Efficacy and Safety of Cilostazol in Mild Cognitive Impairment: A Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2023},
  doi     = {10.1001/jamanetworkopen.2023.44938},
  pmid    = {38048134},
  url     = {https://doi.org/10.1001/jamanetworkopen.2023.44938}
}

@article{billiotidegage2014-25208536,
  author  = {Billioti de Gage, S. and Moride, Y. and Ducruet, T. and Kurth, T. and Verdoux, H. and Tournier, M. and Pariente, A. and Bégaud, B.},
  title   = {{Benzodiazepine use and risk of Alzheimer's disease: case-control study}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2014},
  doi     = {10.1136/bmj.g5205},
  pmid    = {25208536},
  url     = {https://doi.org/10.1136/bmj.g5205}
}

@article{koenig2017-28538088,
  author  = {Koenig, A. M. and Mechanic-Hamilton, D. and Xie, S. X. and Combs, M. F. and Cappola, A. R. and Xie, L. and Detre, J. A. and Wolk, D. A. and others},
  title   = {{Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2017},
  doi     = {10.1097/wad.0000000000000202},
  pmid    = {28538088},
  url     = {https://doi.org/10.1097/wad.0000000000000202}
}

@article{mervin2018-29325922,
  author  = {Mervin, M. C. and Moyle, W. and Jones, C. and Murfield, J. and Draper, B. and Beattie, E. and Shum, D. H. K. and O'Dwyer, S. and others},
  title   = {{The Cost-Effectiveness of Using PARO, a Therapeutic Robotic Seal, to Reduce Agitation and Medication Use in Dementia: Findings from a Cluster-Randomized Controlled Trial}},
  journal = {Journal of the American Medical Directors Association},
  year    = {2018},
  doi     = {10.1016/j.jamda.2017.10.008},
  pmid    = {29325922},
  url     = {https://doi.org/10.1016/j.jamda.2017.10.008}
}

@article{petersen2005-15829527,
  author  = {Petersen, R. C. and Thomas, R. G. and Grundman, M. and Bennett, D. and Doody, R. and Ferris, S. and Galasko, D. and Jin, S. and others},
  title   = {{Vitamin E and donepezil for the treatment of mild cognitive impairment}},
  journal = {The New England journal of medicine},
  year    = {2005},
  doi     = {10.1056/nejmoa050151},
  pmid    = {15829527},
  url     = {https://doi.org/10.1056/nejmoa050151}
}

@article{boada2020-32715623,
  author  = {Boada, M. and López, O. L. and Olazarán, J. and Núñez, L. and Pfeffer, M. and Paricio, M. and Lorites, J. and Piñol-Ripoll, G. and others},
  title   = {{A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12137},
  pmid    = {32715623},
  url     = {https://doi.org/10.1002/alz.12137}
}

@article{ko2022-36399339,
  author  = {Ko, Darae and Lin, Kueiyu Joshua and Bessette, Lily Gui and Lee, Su Been and Walkey, Allan J. and Cheng, Susan C. and Kim, Erin and Glynn, Robert J. and others},
  title   = {{Trends in Use of Oral Anticoagulants in Older Adults With Newly Diagnosed Atrial Fibrillation, 2010-2020}},
  journal = {JAMA Network Open},
  year    = {2022},
  doi     = {10.1001/jamanetworkopen.2022.42964},
  pmid    = {36399339},
  url     = {https://doi.org/10.1001/jamanetworkopen.2022.42964}
}

@article{liu2018-29429971,
  author  = {Liu, E. and Wang, D. and Sperling, R. and Salloway, S. and Fox, N. C. and Blennow, K. and Scheltens, P. and Schmidt, M. E. and others},
  title   = {{Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000005060},
  pmid    = {29429971},
  url     = {https://doi.org/10.1212/wnl.0000000000005060}
}

@article{shao2012-23100399,
  author  = {Shao, H. and Breitner, J. C. and Whitmer, R. A. and Wang, J. and Hayden, K. and Wengreen, H. and Corcoran, C. and Tschanz, J. and others},
  title   = {{Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e318271f823},
  pmid    = {23100399},
  url     = {https://doi.org/10.1212/wnl.0b013e318271f823}
}

@article{lin2021-33881530,
  author  = {Lin, C. H. and Chen, P. K. and Wang, S. H. and Lane, H. Y.},
  title   = {{Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia: Secondary Analysis of a Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2021},
  doi     = {10.1001/jamanetworkopen.2021.6156},
  pmid    = {33881530},
  url     = {https://doi.org/10.1001/jamanetworkopen.2021.6156}
}

@article{feustel2020-31792092,
  author  = {Feustel, A. C. and MacPherson, A. and Fergusson, D. A. and Kieburtz, K. and Kimmelman, J.},
  title   = {{Risks and benefits of unapproved disease-modifying treatments for neurodegenerative disease}},
  journal = {Neurology},
  year    = {2020},
  doi     = {10.1212/wnl.0000000000008699},
  pmid    = {31792092},
  url     = {https://doi.org/10.1212/wnl.0000000000008699}
}

@article{anstey2020-32969833,
  author  = {Anstey, K. J. and Cherbuin, N. and Kim, S. and McMaster, M. and D'Este, C. and Lautenschlager, N. and Rebok, G. and McRae, I. and others},
  title   = {{An Internet-Based Intervention Augmented With a Diet and Physical Activity Consultation to Decrease the Risk of Dementia in At-Risk Adults in a Primary Care Setting: Pragmatic Randomized Controlled Trial}},
  journal = {Journal of medical Internet research},
  year    = {2020},
  doi     = {10.2196/19431},
  pmid    = {32969833},
  url     = {https://doi.org/10.2196/19431}
}

@article{grill2025-39671543,
  author  = {Grill, J. D. and Tam, S. and Thai, G. and Vides, B. and Pierce, A. L. and Green, K. and Gillen, D. L. and Teng, E. and others},
  title   = {{Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000210152},
  pmid    = {39671543},
  url     = {https://doi.org/10.1212/wnl.0000000000210152}
}

@article{tzeng2018-29488144,
  author  = {Tzeng, N. S. and Chung, C. H. and Lin, F. H. and Chiang, C. P. and Yeh, C. B. and Huang, S. Y. and Lu, R. B. and Chang, H. A. and others},
  title   = {{Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections-a Nationwide, Population-Based Cohort Study in Taiwan}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2018},
  doi     = {10.1007/s13311-018-0611-x},
  pmid    = {29488144},
  url     = {https://doi.org/10.1007/s13311-018-0611-x}
}

@article{gauthier2009-19536424,
  author  = {Gauthier, S. and Aisen, P. S. and Ferris, S. H. and Saumier, D. and Duong, A. and Haine, D. and Garceau, D. and Suhy, J. and others},
  title   = {{Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study}},
  journal = {The journal of nutrition, health \& aging},
  year    = {2009},
  doi     = {10.1007/s12603-009-0106-x},
  pmid    = {19536424},
  url     = {https://doi.org/10.1007/s12603-009-0106-x}
}

@article{liu2025-40507855,
  author  = {Liu, X. and Baxley, S. and Hebron, M. and Turner, R. S. and Moussa, C.},
  title   = {{Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26115044},
  pmid    = {40507855},
  url     = {https://doi.org/10.3390/ijms26115044}
}

@article{mulnard2000-10697060,
  author  = {Mulnard, R. A. and Cotman, C. W. and Kawas, C. and van Dyck, C. H. and Sano, M. and Doody, R. and Koss, E. and Pfeiffer, E. and others},
  title   = {{Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study}},
  journal = {JAMA},
  year    = {2000},
  doi     = {10.1001/jama.283.8.1007},
  pmid    = {10697060},
  url     = {https://doi.org/10.1001/jama.283.8.1007}
}

@article{sabbagh2011-21192237,
  author  = {Sabbagh, M. N. and Agro, A. and Bell, J. and Aisen, P. S. and Schweizer, E. and Galasko, D.},
  title   = {{PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2011},
  doi     = {10.1097/wad.0b013e318204b550},
  pmid    = {21192237},
  url     = {https://doi.org/10.1097/wad.0b013e318204b550}
}

@article{gehrman2009-19155748,
  author  = {Gehrman, P. R. and Connor, D. J. and Martin, J. L. and Shochat, T. and Corey-Bloom, J. and Ancoli-Israel, S.},
  title   = {{Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2009},
  doi     = {10.1097/jgp.0b013e318187de18},
  pmid    = {19155748},
  url     = {https://doi.org/10.1097/jgp.0b013e318187de18}
}

@article{giudici2020-33036701,
  author  = {Giudici, K. V. and de Souto Barreto, P. and Beard, J. and Cantet, C. and Araujo de Carvalho, I. and Rolland, Y. and Vellas, B. and {MAPT DSA group}},
  title   = {{Effect of long-term omega-3 supplementation and a lifestyle multidomain intervention on intrinsic capacity among community-dwelling older adults: Secondary analysis of a randomized, placebo-controlled trial (MAPT study)}},
  journal = {Maturitas},
  year    = {2020},
  doi     = {10.1016/j.maturitas.2020.06.012},
  pmid    = {33036701},
  url     = {https://doi.org/10.1016/j.maturitas.2020.06.012}
}

@article{henderson2015-26537053,
  author  = {Henderson, V. W. and Ala, T. and Sainani, K. L. and Bernstein, A. L. and Stephenson, B. S. and Rosen, A. C. and Farlow, M. R.},
  title   = {{Raloxifene for women with Alzheimer disease: A randomized controlled pilot trial}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000002171},
  pmid    = {26537053},
  url     = {https://doi.org/10.1212/wnl.0000000000002171}
}

@article{li2017-28821686,
  author  = {Li, G. and Mayer, C. L. and Morelli, D. and Millard, S. P. and Raskind, W. H. and Petrie, E. C. and Cherrier, M. and Fagan, A. M. and others},
  title   = {{Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults}},
  journal = {Neurology},
  year    = {2017},
  doi     = {10.1212/wnl.0000000000004392},
  pmid    = {28821686},
  url     = {https://doi.org/10.1212/wnl.0000000000004392}
}

@article{berry2023-37040116,
  author  = {Berry, D. A. and Dhadda, S. and Kanekiyo, M. and Li, D. and Swanson, C. J. and Irizarry, M. and Kramer, L. D. and Berry, S. M.},
  title   = {{Lecanemab for Patients With Early Alzheimer Disease: Bayesian Analysis of a Phase 2b Dose-Finding Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2023},
  doi     = {10.1001/jamanetworkopen.2023.7230},
  pmid    = {37040116},
  url     = {https://doi.org/10.1001/jamanetworkopen.2023.7230}
}

@article{wetmore2024-39748836,
  author  = {Wetmore, J. B. and Rodriguez, S. and Diaz Caro, D. and Cabán, M. and Uhlmann, W. and Goldman, J. and Leu, C. S. and Godinez, J. D. and others},
  title   = {{Designing and implementing the IDEAL Study: A randomized clinical trial of APOE genotype disclosure for late-onset Alzheimer's disease in an urban Latino population}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2024},
  doi     = {10.1002/trc2.70016},
  pmid    = {39748836},
  url     = {https://doi.org/10.1002/trc2.70016}
}

@article{ancoliisrael2008-18795985,
  author  = {Ancoli-Israel, S. and Palmer, B. W. and Cooke, JR. and Corey-Bloom, J. and Fiorentino, L. and Natarajan, L. and Liu, L. and Ayalon, L. and others},
  title   = {{Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2008},
  doi     = {10.1111/j.1532-5415.2008.01934.x},
  pmid    = {18795985},
  url     = {https://doi.org/10.1111/j.1532-5415.2008.01934.x}
}

@article{lu2009-19528519,
  author  = {Lu, P. H. and Edland, S. D. and Teng, E. and Tingus, K. and Petersen, R. C. and Cummings, J. L. and {Alzheimer's Disease Cooperative Study Group}},
  title   = {{Donepezil delays progression to AD in MCI subjects with depressive symptoms}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181aa52d3},
  pmid    = {19528519},
  url     = {https://doi.org/10.1212/wnl.0b013e3181aa52d3}
}

@article{boon2025-41109234,
  author  = {Boon, B. D. C. and Piura, Y. D. and Moloney, C. M. and Chalk, J. L. and Lincoln, S. J. and Rutledge, M. H. and Rothberg, D. M. and Kouri, N. and others},
  title   = {{Neuropathological changes and amyloid-related imaging abnormalities in Alzheimer's disease treated with aducanumab versus untreated: a retrospective case-control study}},
  journal = {The Lancet. Neurology},
  year    = {2025},
  doi     = {10.1016/s1474-4422(25)00313-8},
  pmid    = {41109234},
  url     = {https://doi.org/10.1016/s1474-4422(25)00313-8}
}

@article{rosenberg2013-24021498,
  author  = {Rosenberg, P. B. and Lanctôt, K. L. and Drye, L. T. and Herrmann, N. and Scherer, R. W. and Bachman, D. L. and Mintzer, J. E. and {ADMET Investigators}},
  title   = {{Safety and efficacy of methylphenidate for apathy in Alzheimer's disease: a randomized, placebo-controlled trial}},
  journal = {The Journal of clinical psychiatry},
  year    = {2013},
  doi     = {10.4088/jcp.12m08099},
  pmid    = {24021498},
  url     = {https://doi.org/10.4088/jcp.12m08099}
}

@article{vandyck2019-31329216,
  author  = {van Dyck, C. H. and Nygaard, H. B. and Chen, K. and Donohue, M. C. and Raman, R. and Rissman, R. A. and Brewer, J. B. and Koeppe, R. A. and others},
  title   = {{Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2019.2050},
  pmid    = {31329216},
  url     = {https://doi.org/10.1001/jamaneurol.2019.2050}
}

@article{matt2025-40009384,
  author  = {Matt, E. and Mitterwallner, M. and Radjenovic, S. and Grigoryeva, D. and Weber, A. and Stögmann, E. and Domitner, A. and Zettl, A. and others},
  title   = {{Ultrasound Neuromodulation With Transcranial Pulse Stimulation in Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2025},
  doi     = {10.1001/jamanetworkopen.2024.59170},
  pmid    = {40009384},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.59170}
}

@article{viswanathan2009-19153374,
  author  = {Viswanathan, A. and Raj, S. and Greenberg, S. M. and Stampfer, M. and Campbell, S. and Hyman, B. T. and Irizarry, M. C.},
  title   = {{Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/01.wnl.0000339486.63862.db},
  pmid    = {19153374},
  url     = {https://doi.org/10.1212/01.wnl.0000339486.63862.db}
}

@article{mitchell2021-34251396,
  author  = {Mitchell, S. L. and D'Agata, E. M. C. and Hanson, L. C. and Loizeau, A. J. and Habtemariam, D. A. and Tsai, T. and Anderson, R. A. and Shaffer, M. L.},
  title   = {{The Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer Disease and Other Dementias (TRAIN-AD): A Cluster Randomized Clinical Trial}},
  journal = {JAMA internal medicine},
  year    = {2021},
  doi     = {10.1001/jamainternmed.2021.3098},
  pmid    = {34251396},
  url     = {https://doi.org/10.1001/jamainternmed.2021.3098}
}

@article{flo2022-35771851,
  author  = {Flo, B. K. and Matziorinis, A. M. and Skouras, S. and Sudmann, T. T. and Gold, C. and Koelsch, S.},
  title   = {{Study protocol for the Alzheimer and music therapy study: An RCT to compare the efficacy of music therapy and physical activity on brain plasticity, depressive symptoms, and cognitive decline, in a population with and at risk for Alzheimer's disease}},
  journal = {PloS one},
  year    = {2022},
  doi     = {10.1371/journal.pone.0270682},
  pmid    = {35771851},
  url     = {https://doi.org/10.1371/journal.pone.0270682}
}

@article{wang2016-27010616,
  author  = {Wang, J. and Logovinsky, V. and Hendrix, S. B. and Stanworth, S. H. and Perdomo, C. and Xu, L. and Dhadda, S. and Do, I. and others},
  title   = {{ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2016},
  doi     = {10.1136/jnnp-2015-312383},
  pmid    = {27010616},
  url     = {https://doi.org/10.1136/jnnp-2015-312383}
}

@article{yang2013-24086396,
  author  = {Yang, G. and Wang, Y. and Tian, J. and Liu, J. P.},
  title   = {{Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0074916},
  pmid    = {24086396},
  url     = {https://doi.org/10.1371/journal.pone.0074916}
}

@article{jia2017-29284465,
  author  = {Jia, Y. and Zhang, X. and Yu, J. and Han, J. and Yu, T. and Shi, J. and Zhao, L. and Nie, K.},
  title   = {{Acupuncture for patients with mild to moderate Alzheimer's disease: a randomized controlled trial}},
  journal = {BMC complementary and alternative medicine},
  year    = {2017},
  doi     = {10.1186/s12906-017-2064-x},
  pmid    = {29284465},
  url     = {https://doi.org/10.1186/s12906-017-2064-x}
}

@article{dejong2008-18213383,
  author  = {de Jong, D. and Jansen, R. and Hoefnagels, W. and Jellesma-Eggenkamp, M. and Verbeek, M. and Borm, G. and Kremer, B.},
  title   = {{No effect of one-year treatment with indomethacin on Alzheimer's disease progression: a randomized controlled trial}},
  journal = {PloS one},
  year    = {2008},
  doi     = {10.1371/journal.pone.0001475},
  pmid    = {18213383},
  url     = {https://doi.org/10.1371/journal.pone.0001475}
}

@article{scheltens2018-30309389,
  author  = {Scheltens, P. and Hallikainen, M. and Grimmer, T. and Duning, T. and Gouw, A. A. and Teunissen, C. E. and Wink, A. M. and Maruff, P. and others},
  title   = {{Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0431-6},
  pmid    = {30309389},
  url     = {https://doi.org/10.1186/s13195-018-0431-6}
}

@article{lee2023-37930669,
  author  = {Lee, D. and Slomkowski, M. and Hefting, N. and Chen, D. and Larsen, K. G. and Kohegyi, E. and Hobart, M. and Cummings, J. L. and others},
  title   = {{Brexpiprazole for the Treatment of Agitation in Alzheimer Dementia: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.3810},
  pmid    = {37930669},
  url     = {https://doi.org/10.1001/jamaneurol.2023.3810}
}

@article{moraes2008-18198262,
  author  = {Moraes, W. and Poyares, D. and Sukys-Claudino, L. and Guilleminault, C. and Tufik, S.},
  title   = {{Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebo-controlled study}},
  journal = {Chest},
  year    = {2008},
  doi     = {10.1378/chest.07-1446},
  pmid    = {18198262},
  url     = {https://doi.org/10.1378/chest.07-1446}
}

@article{ballard2009-19700946,
  author  = {Ballard, C. and Brown, R. and Fossey, J. and Douglas, S. and Bradley, P. and Hancock, J. and James, I. A. and Juszczak, E. and others},
  title   = {{Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial)}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2009},
  doi     = {10.1097/jgp.0b013e3181b0f8c0},
  pmid    = {19700946},
  url     = {https://doi.org/10.1097/jgp.0b013e3181b0f8c0}
}

@article{koch2020-32667654,
  author  = {Koch, G. and Motta, C. and Bonnì, S. and Pellicciari, M. C. and Picazio, S. and Casula, E. P. and Maiella, M. and Di Lorenzo, F. and others},
  title   = {{Effect of Rotigotine vs Placebo on Cognitive Functions Among Patients With Mild to Moderate Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA network open},
  year    = {2020},
  doi     = {10.1001/jamanetworkopen.2020.10372},
  pmid    = {32667654},
  url     = {https://doi.org/10.1001/jamanetworkopen.2020.10372}
}

@article{bracco2023-37875856,
  author  = {Bracco, L. and Pinto-Carral, A. and Hillaert, L. and Mourey, F.},
  title   = {{Tango-therapy vs physical exercise in older people with dementia; a randomized controlled trial}},
  journal = {BMC geriatrics},
  year    = {2023},
  doi     = {10.1186/s12877-023-04342-x},
  pmid    = {37875856},
  url     = {https://doi.org/10.1186/s12877-023-04342-x}
}

@article{jeste2008-17637610,
  author  = {Jeste, D. V. and Blazer, D. and Casey, D. and Meeks, T. and Salzman, C. and Schneider, L. and Tariot, P. and Yaffe, K.},
  title   = {{ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2008},
  doi     = {10.1038/sj.npp.1301492},
  pmid    = {17637610},
  url     = {https://doi.org/10.1038/sj.npp.1301492}
}

@article{cummings2016-26822146,
  author  = {Cummings, J. L. and Zhong, K. and Kinney, J. W. and Heaney, C. and Moll-Tudla, J. and Joshi, A. and Pontecorvo, M. and Devous, M. and others},
  title   = {{Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2016},
  doi     = {10.1186/s13195-016-0173-2},
  pmid    = {26822146},
  url     = {https://doi.org/10.1186/s13195-016-0173-2}
}

@article{diener2008-18757238,
  author  = {Diener, H. C. and Sacco, R. L. and Yusuf, S. and Cotton, D. and Ounpuu, S. and Lawton, W. A. and Palesch, Y. and Martin, R. H. and others},
  title   = {{Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study}},
  journal = {The Lancet. Neurology},
  year    = {2008},
  doi     = {10.1016/s1474-4422(08)70198-4},
  pmid    = {18757238},
  url     = {https://doi.org/10.1016/s1474-4422(08)70198-4}
}

@article{wilcock2002-12409683,
  author  = {Wilcock, G. and Möbius, H. J. and Stöffler, A. and {MMM 500 group}},
  title   = {{A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500)}},
  journal = {International clinical psychopharmacology},
  year    = {2002},
  doi     = {10.1097/00004850-200211000-00005},
  pmid    = {12409683},
  url     = {https://doi.org/10.1097/00004850-200211000-00005}
}

@article{xu2021-33741639,
  author  = {Xu, H. and Garcia-Ptacek, S. and Jönsson, L. and Wimo, A. and Nordström, P. and Eriksdotter, M.},
  title   = {{Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000011832},
  pmid    = {33741639},
  url     = {https://doi.org/10.1212/wnl.0000000000011832}
}

@article{wang2022-36150665,
  author  = {Wang, L. and Zhang, J. and Guo, C. and He, J. and Zhang, S. and Wang, Y. and Zhao, Y. and Li, L. and others},
  title   = {{The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial}},
  journal = {Brain stimulation},
  year    = {2022},
  doi     = {10.1016/j.brs.2022.09.003},
  pmid    = {36150665},
  url     = {https://doi.org/10.1016/j.brs.2022.09.003}
}

@article{burstein2014-24423155,
  author  = {Burstein, A. H. and Grimes, I. and Galasko, D. R. and Aisen, P. S. and Sabbagh, M. and Mjalli, A. M.},
  title   = {{Effect of TTP488 in patients with mild to moderate Alzheimer's disease}},
  journal = {BMC neurology},
  year    = {2014},
  doi     = {10.1186/1471-2377-14-12},
  pmid    = {24423155},
  url     = {https://doi.org/10.1186/1471-2377-14-12}
}

@article{richards2025-39909068,
  author  = {Richards, Kathy Culpepper and Fry, Liam and Lozano, Alicia J and Ji, Wenyan and Morrison, Janet and Britt, Katherine Carroll and Bliwise, Donald L. and Gooneratne, Nalaka Sudheera and others},
  title   = {{Treatment of Restless Legs Syndrome Improves Agitation and Sleep in Persons with Dementia: A Randomized Trial}},
  journal = {Journal of the American Medical Directors Association},
  year    = {2025},
  doi     = {10.1016/j.jamda.2025.105485},
  pmid    = {39909068},
  url     = {https://doi.org/10.1016/j.jamda.2025.105485}
}

@article{yuan2024-38824515,
  author  = {Yuan, Y. and Yang, Y. and Hu, X. and Zhang, L. and Xiong, Z. and Bai, Y. and others},
  title   = {{Effective dosage and mode of exercise for enhancing cognitive function in Alzheimer's disease and dementia: a systematic review and Bayesian Model-Based Network Meta-analysis of RCTs}},
  journal = {BMC Geriatrics},
  year    = {2024},
  doi     = {10.1186/s12877-024-05060-8},
  pmid    = {38824515},
  url     = {https://doi.org/10.1186/s12877-024-05060-8}
}

@article{xu2024-39177108,
  author  = {Xu, H. and Habich, A. and Ferreira, D. and Elisabet, L. and Westman, E. and Eriksdotter, M.},
  title   = {{Long-term effects of cholinesterase inhibitors and memantine on cognitive decline, cardiovascular events, and mortality in dementia with Lewy bodies: An up to 10-year follow-up study}},
  journal = {Alzheimer's \& Dementia},
  year    = {2024},
  doi     = {10.1002/alz.14118},
  pmid    = {39177108},
  url     = {https://doi.org/10.1002/alz.14118}
}

@article{fleisher2026-42441396,
  author  = {Fleisher, Adam S and Munsie, Leanne and Mancini, Michele and Cheng, Yun-Ju and Guo, Jiaying and Nuthall, Hugh and Otero, Diana Svaldi and Kotari, Vikas and others},
  title   = {{Ceperognastat in Early Symptomatic Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA},
  year    = {2026},
  doi     = {10.1001/jama.2026.12768},
  pmid    = {42441396},
  url     = {https://doi.org/10.1001/jama.2026.12768}
}

@article{schneider2016-26771737,
  author  = {Schneider, L. S. and Frangakis, C. and Drye, L. T. and Devanand, D. P. and Marano, C. M. and Mintzer, J. and Mulsant, B. H. and Munro, C. A. and others},
  title   = {{Heterogeneity of Treatment Response to Citalopram for Patients With Alzheimer's Disease With Aggression or Agitation: The CitAD Randomized Clinical Trial}},
  journal = {The American journal of psychiatry},
  year    = {2016},
  doi     = {10.1176/appi.ajp.2015.15050648},
  pmid    = {26771737},
  url     = {https://doi.org/10.1176/appi.ajp.2015.15050648}
}

@article{munro2012-23032478,
  author  = {Munro, C. A. and Longmire, C. F. and Drye, L. T. and Martin, B. K. and Frangakis, C. E. and Meinert, C. L. and Mintzer, J. E. and Porsteinsson, A. P. and others},
  title   = {{Cognitive outcomes after sertaline treatment in patients with depression of Alzheimer disease}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2012},
  doi     = {10.1097/jgp.0b013e31826ce4c5},
  pmid    = {23032478},
  url     = {https://doi.org/10.1097/jgp.0b013e31826ce4c5}
}

@article{dyer2020-31604674,
  author  = {Dyer, A. H. and Murphy, C. and Lawlor, B. and Kennelly, S. P. and {NILVAD Study Group}},
  title   = {{Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD}},
  journal = {Journal of the American Medical Directors Association},
  year    = {2020},
  doi     = {10.1016/j.jamda.2019.08.006},
  pmid    = {31604674},
  url     = {https://doi.org/10.1016/j.jamda.2019.08.006}
}

@article{flicker2001-11405971,
  author  = {Flicker, L. and Grimley Evans, G.},
  title   = {{Piracetam for dementia or cognitive impairment}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2001},
  doi     = {10.1002/14651858.cd001011},
  pmid    = {11405971},
  url     = {https://doi.org/10.1002/14651858.cd001011}
}

@article{higgins2000-11034695,
  author  = {Higgins, J. P. and Flicker, L.},
  title   = {{Lecithin for dementia and cognitive impairment}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2000},
  doi     = {10.1002/14651858.cd001015},
  pmid    = {11034695},
  url     = {https://doi.org/10.1002/14651858.cd001015}
}

@article{forcano2025-40664536,
  author  = {Forcano, L. and Soldevila-Domenech, N. and Boronat, A. and Sánchez-Benavides, G. and Puig-Pijoan, A. and Lorenzo, T. and Aldea-Perona, A. and Suárez-Calvet, M. and others},
  title   = {{A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study)}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100271},
  pmid    = {40664536},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100271}
}

@article{vanderlip2026-41653883,
  author  = {Vanderlip, C. R. and Gillen, D. L. and Grill, J. D. and Stark, C. E. L.},
  title   = {{Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer's trials}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2026},
  doi     = {10.1016/j.tjpad.2026.100503},
  pmid    = {41653883},
  url     = {https://doi.org/10.1016/j.tjpad.2026.100503}
}

@article{wilcock2000-11110737,
  author  = {Wilcock, G. K. and Lilienfeld, S. and Gaens, E.},
  title   = {{Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. Galantamine International-1 Study Group}},
  journal = {BMJ (Clinical research ed.)},
  year    = {2000},
  doi     = {10.1136/bmj.321.7274.1445},
  pmid    = {11110737},
  url     = {https://doi.org/10.1136/bmj.321.7274.1445}
}

@article{banerjee2011-21764118,
  author  = {Banerjee, S. and Hellier, J. and Dewey, M. and Romeo, R. and Ballard, C. and Baldwin, R. and Bentham, P. and Fox, C. and others},
  title   = {{Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial}},
  journal = {Lancet (London, England)},
  year    = {2011},
  doi     = {10.1016/s0140-6736(11)60830-1},
  pmid    = {21764118},
  url     = {https://doi.org/10.1016/s0140-6736(11)60830-1}
}

@article{akhondzadeh2003-12810768,
  author  = {Akhondzadeh, S. and Noroozian, M. and Mohammadi, M. and Ohadinia, S. and Jamshidi, A. H. and Khani, M.},
  title   = {{Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2003},
  doi     = {10.1136/jnnp.74.7.863},
  pmid    = {12810768},
  url     = {https://doi.org/10.1136/jnnp.74.7.863}
}

@article{rockwood2006-16554498,
  author  = {Rockwood, K. and Fay, S. and Song, X. and MacKnight, C. and Gorman, M.},
  title   = {{Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: a randomized controlled trial}},
  journal = {CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne},
  year    = {2006},
  doi     = {10.1503/cmaj.051432},
  pmid    = {16554498},
  url     = {https://doi.org/10.1503/cmaj.051432}
}

@article{vandyck2025-41355080,
  author  = {van Dyck, C. H. and Sperling, R. and Johnson, K. and Dhadda, S. and Kanekiyo, M. and Li, D. and Gee, M. and Hersch, S. and Irizarry, M. and Kramer, L.},
  title   = {{Long-term safety and efficacy of lecanemab in early Alzheimer's disease: Results from the Clarity AD open-label extension study}},
  journal = {Alzheimer's \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70905},
  pmid    = {41355080},
  url     = {https://doi.org/10.1002/alz.70905}
}

@article{atri2026-42128444,
  author  = {Atri, A. and Apostolova, L. G. and Iwata, A. and Wessels, A. M. and Atkins, A. and Lu, M. and Ye, W. and Ryan, S. and Doty, E. G.},
  title   = {{Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial}},
  journal = {Neurology: Clinical Practice},
  year    = {2026},
  doi     = {10.1212/CPJ.0000000000200621},
  pmid    = {42128444},
  url     = {https://doi.org/10.1212/CPJ.0000000000200621}
}

@article{delrieu2023-37872582,
  author  = {Delrieu, J. and Vellas, B. and Guyonnet, S. and Cantet, C. and Ovod, V. and Li, Y. and Bollinger, J. and Bateman, R. and others},
  title   = {{Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2023},
  doi     = {10.1186/s13195-023-01325-3},
  pmid    = {37872582},
  url     = {https://doi.org/10.1186/s13195-023-01325-3}
}

@article{fields2012-21775876,
  author  = {Fields, C. and Drye, L. and Vaidya, V. and Lyketsos, C. and {ADAPT Research Group}},
  title   = {{Celecoxib or naproxen treatment does not benefit depressive symptoms in persons age 70 and older: findings from a randomized controlled trial}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2012},
  doi     = {10.1097/jgp.0b013e318227f4da},
  pmid    = {21775876},
  url     = {https://doi.org/10.1097/jgp.0b013e318227f4da}
}

@article{leoutsakos2012-21560159,
  author  = {Leoutsakos, J. M. and Muthen, B. O. and Breitner, J. C. and Lyketsos, C. G. and {ADAPT Research Team}},
  title   = {{Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial}},
  journal = {International journal of geriatric psychiatry},
  year    = {2012},
  doi     = {10.1002/gps.2723},
  pmid    = {21560159},
  url     = {https://doi.org/10.1002/gps.2723}
}

@article{hartin2016-27485822,
  author  = {Hartin, P. J. and Nugent, C. D. and McClean, S. I. and Cleland, I. and Tschanz, J. T. and Clark, C. J. and Norton, M. C.},
  title   = {{The Empowering Role of Mobile Apps in Behavior Change Interventions: The Gray Matters Randomized Controlled Trial}},
  journal = {JMIR mHealth and uHealth},
  year    = {2016},
  doi     = {10.2196/mhealth.4878},
  pmid    = {27485822},
  url     = {https://doi.org/10.2196/mhealth.4878}
}

@article{coelho2001-11405996,
  author  = {Coelho, F. and Birks, J.},
  title   = {{Physostigmine for Alzheimer's disease}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2001},
  doi     = {10.1002/14651858.cd001499},
  pmid    = {11405996},
  url     = {https://doi.org/10.1002/14651858.cd001499}
}

@article{grill2024-37830926,
  author  = {Grill, J. D. and Flournoy, C. and Dhadda, S. and Ernstrom, K. and Sperling, R. and Molina-Henry, D. and Tranotti, K. and Harris, R. and others},
  title   = {{Eligibility Rates among Racially and Ethnically Diverse US Participants in Phase 2 and Phase 3 Placebo-Controlled, Double-Blind, Randomized Trials of Lecanemab and Elenbecestat in Early Alzheimer Disease}},
  journal = {Annals of neurology},
  year    = {2024},
  doi     = {10.1002/ana.26819},
  pmid    = {37830926},
  url     = {https://doi.org/10.1002/ana.26819}
}

@article{boespflug2018-28221821,
  author  = {Boespflug, E. L. and Eliassen, J. C. and Dudley, J. A. and Shidler, M. D. and Kalt, W. and Summer, S. S. and Stein, A. L. and Stover, A. N. and others},
  title   = {{Enhanced neural activation with blueberry supplementation in mild cognitive impairment}},
  journal = {Nutritional neuroscience},
  year    = {2018},
  doi     = {10.1080/1028415x.2017.1287833},
  pmid    = {28221821},
  url     = {https://doi.org/10.1080/1028415x.2017.1287833}
}

@article{reisberg2003-12672860,
  author  = {Reisberg, B. and Doody, R. and Stöffler, A. and Schmitt, F. and Ferris, S. and Möbius, H. J. and {Memantine Study Group}},
  title   = {{Memantine in moderate-to-severe Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2003},
  doi     = {10.1056/nejmoa013128},
  pmid    = {12672860},
  url     = {https://doi.org/10.1056/nejmoa013128}
}

@article{johnson2013-23375563,
  author  = {Johnson, K. A. and Sperling, R. A. and Gidicsin, C. M. and Carmasin, J. S. and Maye, J. E. and Coleman, R. E. and Reiman, E. M. and Sabbagh, M. N. and others},
  title   = {{Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2013},
  doi     = {10.1016/j.jalz.2012.10.007},
  pmid    = {23375563},
  url     = {https://doi.org/10.1016/j.jalz.2012.10.007}
}

@article{jack2008-17452062,
  author  = {Jack, C. R. and Petersen, R. C. and Grundman, M. and Jin, S. and Gamst, A. and Ward, C. P. and Sencakova, D. and Doody, R. S. and others},
  title   = {{Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI}},
  journal = {Neurobiology of aging},
  year    = {2008},
  doi     = {10.1016/j.neurobiolaging.2007.03.004},
  pmid    = {17452062},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2007.03.004}
}

@article{stein2011-21694461,
  author  = {Stein, M. S. and Scherer, S. C. and Ladd, K. S. and Harrison, L. C.},
  title   = {{A randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2011},
  doi     = {10.3233/jad-2011-110149},
  pmid    = {21694461},
  url     = {https://doi.org/10.3233/jad-2011-110149}
}

@article{mittelman2008-18978250,
  author  = {Mittelman, M. S. and Brodaty, H. and Wallen, A. S. and Burns, A.},
  title   = {{A three-country randomized controlled trial of a psychosocial intervention for caregivers combined with pharmacological treatment for patients with Alzheimer disease: effects on caregiver depression}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2008},
  doi     = {10.1097/jgp.0b013e3181898095},
  pmid    = {18978250},
  url     = {https://doi.org/10.1097/jgp.0b013e3181898095}
}

@article{stanley2013-23567399,
  author  = {Stanley, M. A. and Calleo, J. and Bush, A. L. and Wilson, N. and Snow, A. L. and Kraus-Schuman, C. and Paukert, A. L. and Petersen, N. J. and others},
  title   = {{The peaceful mind program: a pilot test of a cognitive-behavioral therapy-based intervention for anxious patients with dementia}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2013},
  doi     = {10.1016/j.jagp.2013.01.007},
  pmid    = {23567399},
  url     = {https://doi.org/10.1016/j.jagp.2013.01.007}
}

@article{roberts2012-22498844,
  author  = {Roberts, J. S. and Chen, C. A. and Uhlmann, W. R. and Green, R. C.},
  title   = {{Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease}},
  journal = {Genetics in medicine : official journal of the American College of Medical Genetics},
  year    = {2012},
  doi     = {10.1038/gim.2012.37},
  pmid    = {22498844},
  url     = {https://doi.org/10.1038/gim.2012.37}
}

@article{sekikawa2025-40838083,
  author  = {Sekikawa, A. and Wharton, W. and Murray-Krezan, C. and Wu, M. and Chang, Y. and Snitz, B. E. and Coccari, M. and Yang, S. and others},
  title   = {{ACE trial design: Equol targeting estrogen receptor-β in vascular and cognitive aging}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2025},
  doi     = {10.1002/trc2.70144},
  pmid    = {40838083},
  url     = {https://doi.org/10.1002/trc2.70144}
}

@article{burns1999-10325453,
  author  = {Burns, A. and Rossor, M. and Hecker, J. and Gauthier, S. and Petit, H. and Möller, H. J. and Rogers, S. L. and Friedhoff, L. T.},
  title   = {{The effects of donepezil in Alzheimer's disease - results from a multinational trial}},
  journal = {Dementia and geriatric cognitive disorders},
  year    = {1999},
  doi     = {10.1159/000017126},
  pmid    = {10325453},
  url     = {https://doi.org/10.1159/000017126}
}

@article{jeremic2025-40194268,
  author  = {Jeremic, D. and Navarro-Lopez, J. D. and Jimenez-Diaz, L.},
  title   = {{Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application}},
  journal = {Journal of medical Internet research},
  year    = {2025},
  doi     = {10.2196/68454},
  pmid    = {40194268},
  url     = {https://doi.org/10.2196/68454}
}

@article{gibson2020-33074237,
  author  = {Gibson, G. E. and Luchsinger, J. A. and Cirio, R. and Chen, H. and Franchino-Elder, J. and Hirsch, J. A. and Bettendorff, L. and Chen, Z. and others},
  title   = {{Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200896},
  pmid    = {33074237},
  url     = {https://doi.org/10.3233/jad-200896}
}

@article{doody2014-24450890,
  author  = {Doody, Rachelle Smith and Thomas, Ronald G. and Farlow, Martin Rhys and Iwatsubo, Takeshi and Vellas, Bruno J. and Joffe, Steven and Kieburtz, Karl D. and Raman, Rema and Sun, Xiaoying and Aisen, Paul S. S. and Siemers, Eric and Liu‐Seifert, Hong and Mohs, Richard C.},
  title   = {{Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease}},
  journal = {New England Journal of Medicine},
  year    = {2014},
  doi     = {10.1056/nejmoa1312889},
  pmid    = {24450890},
  url     = {https://doi.org/10.1056/nejmoa1312889}
}

@article{nakamura2024-39369280,
  author  = {Nakamura, Y. and Adachi, J. and Hirota, N. and Iba, K. and Shimizu, K. and Nakai, M. and Takahashi, K. and Mori, N.},
  title   = {{Brexpiprazole treatment for agitation in Alzheimer's dementia: A randomized study}},
  journal = {Alzheimer's \& Dementia},
  year    = {2024},
  doi     = {10.1002/alz.14282},
  pmid    = {39369280},
  url     = {https://doi.org/10.1002/alz.14282}
}

@article{havrengthery2024-38812028,
  author  = {Havreng-Théry, C. and Oquendo, B. and Zolnowski-Kolp, V. and Krolak-Salmon, P. and Bertin-Hugault, F. and Lafuente-Lafuente, C. and Belmin, J.},
  title   = {{Cholinesterase inhibitors and memantine are associated with a reduced mortality in nursing home residents with dementia: a longitudinal observational study}},
  journal = {Alzheimer's Research \& Therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01481-0},
  pmid    = {38812028},
  url     = {https://doi.org/10.1186/s13195-024-01481-0}
}

@article{pilotto2009-19738170,
  author  = {Pilotto, A. and Franceschi, M. and D'Onofrio, G. and Bizzarro, A. and Mangialasche, F. and Cascavilla, L. and Paris, F. and Matera, M. G. and others},
  title   = {{Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181b6bbe3},
  pmid    = {19738170},
  url     = {https://doi.org/10.1212/wnl.0b013e3181b6bbe3}
}

@article{yao2022-35700915,
  author  = {Yao, Q. and Tang, F. and Wang, Y. and Yan, Y. and Dong, L. and Wang, T. and Zhu, D. and Tian, M. and others},
  title   = {{Effect of cerebellum stimulation on cognitive recovery in patients with Alzheimer disease: A randomized clinical trial}},
  journal = {Brain stimulation},
  year    = {2022},
  doi     = {10.1016/j.brs.2022.06.004},
  pmid    = {35700915},
  url     = {https://doi.org/10.1016/j.brs.2022.06.004}
}

@article{kieburtz2010-20142523,
  author  = {Kieburtz, K. and McDermott, M. P. and Voss, T. S. and Corey-Bloom, J. and Deuel, L. M. and Dorsey, E. R. and Factor, S. and Geschwind, M. D. and others},
  title   = {{A randomized, placebo-controlled trial of latrepirdine in Huntington disease}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2009.334},
  pmid    = {20142523},
  url     = {https://doi.org/10.1001/archneurol.2009.334}
}

@article{deheus2019-31088188,
  author  = {de Heus, R. A. A. and Donders, R. and Santoso, A. M. M. and Olde Rikkert, M. G. M. and Lawlor, B. A. and Claassen, J. A. H. R. and {Nilvad Study Group}},
  title   = {{Blood Pressure Lowering With Nilvadipine in Patients With Mild-to-Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension}},
  journal = {Journal of the American Heart Association},
  year    = {2019},
  doi     = {10.1161/jaha.119.011938},
  pmid    = {31088188},
  url     = {https://doi.org/10.1161/jaha.119.011938}
}

@article{lee2024-38875437,
  author  = {Lee, W. and Kim, M.},
  title   = {{Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial}},
  journal = {Medicine},
  year    = {2024},
  doi     = {10.1097/md.0000000000038067},
  pmid    = {38875437},
  url     = {https://doi.org/10.1097/md.0000000000038067}
}

@article{jacobson2025-40844772,
  author  = {Jacobson, M. and Molina-Henry, D. and Chang, T. Y. and Jimenez-Maggiora, G. A. and Pramanik, R. and Shah, S. B. and Aisen, P. S.},
  title   = {{Financial Incentives to Increase Diversity of Older Participants in a Memory Concerns Registry: A Randomized Clinical Trial}},
  journal = {JAMA health forum},
  year    = {2025},
  doi     = {10.1001/jamahealthforum.2025.2273},
  pmid    = {40844772},
  url     = {https://doi.org/10.1001/jamahealthforum.2025.2273}
}

@article{cai2013-23183138,
  author  = {Cai, X. and Campbell, N. and Khan, B. and Callahan, C. and Boustani, M.},
  title   = {{Long-term anticholinergic use and the aging brain}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2013},
  doi     = {10.1016/j.jalz.2012.02.005},
  pmid    = {23183138},
  url     = {https://doi.org/10.1016/j.jalz.2012.02.005}
}

@article{schneider2011-21220675,
  author  = {Schneider, L. S. and Insel, P. S. and Weiner, M. W. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.343},
  pmid    = {21220675},
  url     = {https://doi.org/10.1001/archneurol.2010.343}
}

@article{tang2025-40193118,
  author  = {Tang, Huilin and Donahoo, William Troy and DeKosky, Steven T. and Lee, Yao An and Kotecha, Pareeta and Svensson, Mikael A. and Bian, Jiang and Guo, Jingchuan Serena},
  title   = {{GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related Dementias}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.0353},
  pmid    = {40193118},
  url     = {https://doi.org/10.1001/jamaneurol.2025.0353}
}

@article{sano1997-9110909,
  author  = {Sano, Mary and Ernesto, Christopher and Thomas, Ronald G. and Klauber, Melville R. and Schafer, Kimberly A and Grundman, Michael and Woodbury, Peter and Growdon, John H. and Cotman, Carl W. and Pfeiffer, Eric A. and Schneider, Lon S. and Thal, Leon J.},
  title   = {{A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study}},
  journal = {New England Journal of Medicine},
  year    = {1997},
  doi     = {10.1056/nejm199704243361704},
  pmid    = {9110909},
  url     = {https://doi.org/10.1056/nejm199704243361704}
}

@article{rosenberg2025-41350162,
  author  = {Rosenberg, P. B. and Amjad, H. and Burhanullah, H. and Nowrangi, M. and Vandrey, R. and Pierre, M. J. and Outen, J. D. and Schultz, M. and Marano, C. and Agronin, M. and others},
  title   = {{A Randomized Controlled Trial of the Safety and Efficacy of Dronabinol for Agitation in Alzheimer's Disease}},
  journal = {The American Journal of Geriatric Psychiatry},
  year    = {2025},
  doi     = {10.1016/j.jagp.2025.10.011},
  pmid    = {41350162},
  url     = {https://doi.org/10.1016/j.jagp.2025.10.011}
}

@article{ballard2015-25523285,
  author  = {Ballard, C. and Thomas, A. and Gerry, S. and Yu, L. M. and Aarsland, D. and Merritt, C. and Corbett, A. and Davison, C. and others},
  title   = {{A double-blind randomized placebo-controlled withdrawal trial comparing memantine and antipsychotics for the long-term treatment of function and neuropsychiatric symptoms in people with Alzheimer's disease (MAIN-AD)}},
  journal = {Journal of the American Medical Directors Association},
  year    = {2015},
  doi     = {10.1016/j.jamda.2014.11.002},
  pmid    = {25523285},
  url     = {https://doi.org/10.1016/j.jamda.2014.11.002}
}

@article{woodworth2023-37831492,
  author  = {Woodworth, E. C. and Briskin, E. A. and Plys, E. and Macklin, E. and Tatar, R. G. and Huberty, J. and Vranceanu, A. M.},
  title   = {{Mindfulness-Based App to Reduce Stress in Caregivers of Persons With Alzheimer Disease and Related Dementias: Protocol for a Single-Blind Feasibility Proof-of-Concept Randomized Controlled Trial}},
  journal = {JMIR research protocols},
  year    = {2023},
  doi     = {10.2196/50108},
  pmid    = {37831492},
  url     = {https://doi.org/10.2196/50108}
}

@article{saleh2023-36624497,
  author  = {Saleh, R. N. M. and Hornberger, M. and Ritchie, C. W. and Minihane, A. M.},
  title   = {{Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer's Disease (EPAD) cohort}},
  journal = {Alzheimer's research \& therapy},
  year    = {2023},
  doi     = {10.1186/s13195-022-01121-5},
  pmid    = {36624497},
  url     = {https://doi.org/10.1186/s13195-022-01121-5}
}

@article{akhondzadeh2010-20831681,
  author  = {Akhondzadeh, S. and Sabet, M. S. and Harirchian, M. H. and Togha, M. and Cheraghmakani, H. and Razeghi, S. and SSh, Hejazi and Yousefi, M. H. and others},
  title   = {{Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial}},
  journal = {Journal of clinical pharmacy and therapeutics},
  year    = {2010},
  doi     = {10.1111/j.1365-2710.2009.01133.x},
  pmid    = {20831681},
  url     = {https://doi.org/10.1111/j.1365-2710.2009.01133.x}
}

@article{onder2005-16260821,
  author  = {Onder, G. and Zanetti, O. and Giacobini, E. and Frisoni, G. B. and Bartorelli, L. and Carbone, G. and Lambertucci, P. and others},
  title   = {{Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: randomised controlled trial}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2005},
  doi     = {10.1192/bjp.187.5.450},
  pmid    = {16260821},
  url     = {https://doi.org/10.1192/bjp.187.5.450}
}

@article{albertyn2025-40479610,
  author  = {Albertyn, C. P. and Guu, T. W. and Chu, P. and Creese, B. and Young, A. and Velayudhan, L. and Bhattacharyya, S. and Jafari, H. and Kaur, S. and Kandangwa, P. and others},
  title   = {{Sativex (nabiximols) for the treatment of Agitation \& Aggression in Alzheimer's dementia in UK nursing homes: a randomised, double-blind, placebo-controlled feasibility trial}},
  journal = {Age and Ageing},
  year    = {2025},
  doi     = {10.1093/ageing/afaf149},
  pmid    = {40479610},
  url     = {https://doi.org/10.1093/ageing/afaf149}
}

@article{carrie2012-22499458,
  author  = {Carrié, I. and van Kan, G. A. and Gillette-Guyonnet, S. and Andrieu, S. and Dartigues, J. F. and Touchon, J. and Dantoine, T. and Rouaud, O. and others},
  title   = {{Recruitment strategies for preventive trials. The MAPT study (MultiDomain Alzheimer Preventive Trial)}},
  journal = {The journal of nutrition, health \& aging},
  year    = {2012},
  doi     = {10.1007/s12603-012-0046-8},
  pmid    = {22499458},
  url     = {https://doi.org/10.1007/s12603-012-0046-8}
}

@article{roach2011-21937893,
  author  = {Roach, K. E. and Tappen, R. M. and Kirk-Sanchez, N. and Williams, C. L. and Loewenstein, D.},
  title   = {{A randomized controlled trial of an activity specific exercise program for individuals with Alzheimer disease in long-term care settings}},
  journal = {Journal of geriatric physical therapy (2001)},
  year    = {2011},
  doi     = {10.1519/jpt.0b013e31820aab9c},
  pmid    = {21937893},
  url     = {https://doi.org/10.1519/jpt.0b013e31820aab9c}
}

@article{brodaty2009-19705519,
  author  = {Brodaty, H. and Mittelman, M. and Gibson, L. and Seeher, K. and Burns, A.},
  title   = {{The effects of counseling spouse caregivers of people with Alzheimer disease taking donepezil and of country of residence on rates of admission to nursing homes and mortality}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2009},
  doi     = {10.1097/jgp.0b013e3181a65187},
  pmid    = {19705519},
  url     = {https://doi.org/10.1097/jgp.0b013e3181a65187}
}

@article{drye2013-23567407,
  author  = {Drye, L. T. and Scherer, R. W. and Lanctôt, K. L. and Rosenberg, P. B. and Herrmann, N. and Bachman, D. and Mintzer, J. E. and {ADMET Research Group}},
  title   = {{Designing a trial to evaluate potential treatments for apathy in dementia: the apathy in dementia methylphenidate trial (ADMET)}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2013},
  doi     = {10.1016/j.jagp.2012.12.018},
  pmid    = {23567407},
  url     = {https://doi.org/10.1016/j.jagp.2012.12.018}
}

@article{mohamed2012-21939611,
  author  = {Mohamed, S. and Rosenheck, R. and Lyketsos, C. G. and Kaczynski, R. and Sultzer, D. L. and Schneider, L. S.},
  title   = {{Effect of second-generation antipsychotics on caregiver burden in Alzheimer's disease}},
  journal = {The Journal of clinical psychiatry},
  year    = {2012},
  doi     = {10.4088/jcp.10m06574},
  pmid    = {21939611},
  url     = {https://doi.org/10.4088/jcp.10m06574}
}

@article{zuidersma2019-31084994,
  author  = {Zuidersma, M. and Chua, K. C. and Hellier, J. and Voshaar, R. O. and Banerjee, S. and {HTA-SADD Investigator Group}},
  title   = {{Sertraline and Mirtazapine Versus Placebo in Subgroups of Depression in Dementia: Findings From the HTA-SADD Randomized Controlled Trial}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2019},
  doi     = {10.1016/j.jagp.2019.03.021},
  pmid    = {31084994},
  url     = {https://doi.org/10.1016/j.jagp.2019.03.021}
}

@article{wang2019-31488882,
  author  = {Wang, X. and Sun, G. and Feng, T. and Zhang, J. and Huang, X. and Wang, T. and Xie, Z. and Chu, X. and others},
  title   = {{Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression}},
  journal = {Cell research},
  year    = {2019},
  doi     = {10.1038/s41422-019-0216-x},
  pmid    = {31488882},
  url     = {https://doi.org/10.1038/s41422-019-0216-x}
}

@article{tariot2018-29955659,
  author  = {Tariot, P. N. and Lopera, F. and Langbaum, J. B. and Thomas, R. G. and Hendrix, S. and Schneider, L. S. and Rios-Romenets, S. and Giraldo, M. and others},
  title   = {{The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2018},
  doi     = {10.1016/j.trci.2018.02.002},
  pmid    = {29955659},
  url     = {https://doi.org/10.1016/j.trci.2018.02.002}
}

@article{loomis2024-38165296,
  author  = {Loomis, S. J. and Miller, R. and Castrillo-Viguera, C. and Umans, K. and Cheng, W. and O'Gorman, J. and Hughes, R. and Budd Haeberlein, S. and others},
  title   = {{Genome-Wide Association Studies of ARIA From the Aducanumab Phase 3 ENGAGE and EMERGE Studies}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000207919},
  pmid    = {38165296},
  url     = {https://doi.org/10.1212/wnl.0000000000207919}
}

@article{knight2018-29734182,
  author  = {Knight, R. and Khondoker, M. and Magill, N. and Stewart, R. and Landau, S.},
  title   = {{A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia}},
  journal = {Dementia and geriatric cognitive disorders},
  year    = {2018},
  doi     = {10.1159/000486546},
  pmid    = {29734182},
  url     = {https://doi.org/10.1159/000486546}
}

@article{mamas2025-40980721,
  author  = {Mamas, Mamas A. and Bays, Harold Edward and Li, Runjia and Upadhyay, Navneet and Irani, Tanya and Şenyücel, Çağrı and Dunn, Julia P. and Liu‐Seifert, Hong},
  title   = {{Tirzepatide compared with semaglutide and 10-year cardiovascular disease risk reduction in obesity: post-hoc analysis of the SURMOUNT-5 trial}},
  journal = {European Heart Journal Open},
  year    = {2025},
  doi     = {10.1093/ehjopen/oeaf117},
  pmid    = {40980721},
  url     = {https://doi.org/10.1093/ehjopen/oeaf117}
}

@article{wu2025-41420258,
  author  = {Wu, C. Y. and Alkabbani, W. and Shah, B. R. and Kapral, M. K. and Edwards, J. D. and Maxwell, C. J. and others},
  title   = {{Comparative dementia risk with GLP1 receptor agonists, SGLT2 inhibitors, or DPP4 inhibitors: a population-based cohort study}},
  journal = {Alzheimer's Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01929-x},
  pmid    = {41420258},
  url     = {https://doi.org/10.1186/s13195-025-01929-x}
}

@article{agarwal2023-36889921,
  author  = {Agarwal, P. and Leurgans, S. E. and Agrawal, S. and Aggarwal, N. T. and Cherian, L. J. and James, B. D. and Dhana, K. and others},
  title   = {{Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology}},
  journal = {Neurology},
  year    = {2023},
  doi     = {10.1212/wnl.0000000000207176},
  pmid    = {36889921},
  url     = {https://doi.org/10.1212/wnl.0000000000207176}
}

@article{black2010-20505438,
  author  = {Black, R. S. and Sperling, R. A. and Safirstein, B. and Motter, R. N. and Pallay, A. and Nichols, A. and Grundman, M.},
  title   = {{A single ascending dose study of bapineuzumab in patients with Alzheimer disease}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2010},
  doi     = {10.1097/wad.0b013e3181c53b00},
  pmid    = {20505438},
  url     = {https://doi.org/10.1097/wad.0b013e3181c53b00}
}

@article{gu2021-34402024,
  author  = {Gu, J. and Li, Z. and Chen, H. and Xu, X. and Li, Y. and Gui, Y.},
  title   = {{Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial}},
  journal = {Neurology and therapy},
  year    = {2021},
  doi     = {10.1007/s40120-021-00271-2},
  pmid    = {34402024},
  url     = {https://doi.org/10.1007/s40120-021-00271-2}
}

@article{lavretsky2010-20104071,
  author  = {Lavretsky, H. and Siddarth, P. and Irwin, M. R.},
  title   = {{Improving depression and enhancing resilience in family dementia caregivers: a pilot randomized placebo-controlled trial of escitalopram}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2010},
  doi     = {10.1097/jgp.0b013e3181beab1e},
  pmid    = {20104071},
  url     = {https://doi.org/10.1097/jgp.0b013e3181beab1e}
}

@article{regan2017-28034509,
  author  = {Regan, B. and Wells, Y. and Farrow, M. and O'Halloran, P. and Workman, B.},
  title   = {{MAXCOG-Maximizing Cognition: A Randomized Controlled Trial of the Efficacy of Goal-Oriented Cognitive Rehabilitation for People with Mild Cognitive Impairment and Early Alzheimer Disease}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2017},
  doi     = {10.1016/j.jagp.2016.11.008},
  pmid    = {28034509},
  url     = {https://doi.org/10.1016/j.jagp.2016.11.008}
}

@article{papatsimpas2023-37509042,
  author  = {Papatsimpas, V. and Vrouva, S. and Papathanasiou, G. and Papadopoulou, M. and Bouzineki, C. and Kanellopoulou, S. and Moutafi, D. and Bakalidou, D.},
  title   = {{Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer's Disease? A Randomized Controlled Trial}},
  journal = {Brain sciences},
  year    = {2023},
  doi     = {10.3390/brainsci13071112},
  pmid    = {37509042},
  url     = {https://doi.org/10.3390/brainsci13071112}
}

@article{silveira2025-40587145,
  author  = {Silveira, C. R. A. and Coleman, K. K. L. and Borron, K. and Tirona, R. G. and Rupar, C. A. and Zou, G. and Hegele, R. A. and Wellington, C. and others},
  title   = {{Ambroxol as a Treatment for Parkinson Disease Dementia: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.1687},
  pmid    = {40587145},
  url     = {https://doi.org/10.1001/jamaneurol.2025.1687}
}

@article{flynnlongmire2014-24314887,
  author  = {Flynn Longmire, C. V. and Drye, L. T. and Frangakis, C. E. and Martin, B. K. and Meinert, C. L. and Mintzer, J. E. and Munro, C. A. and Porsteinsson, A. P. and others},
  title   = {{Is sertraline treatment or depression remission in depressed Alzheimer patients associated with improved caregiver well being? Depression in Alzheimer's Disease Study 2}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2014},
  doi     = {10.1016/j.jagp.2013.02.014},
  pmid    = {24314887},
  url     = {https://doi.org/10.1016/j.jagp.2013.02.014}
}

@article{volak2013-22725836,
  author  = {Volak, L. P. and Hanley, M. J. and Masse, G. and Hazarika, S. and Harmatz, J. S. and Badmaev, V. and Majeed, M. and Greenblatt, D. J. and others},
  title   = {{Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers}},
  journal = {British journal of clinical pharmacology},
  year    = {2013},
  doi     = {10.1111/j.1365-2125.2012.04364.x},
  pmid    = {22725836},
  url     = {https://doi.org/10.1111/j.1365-2125.2012.04364.x}
}

@article{abushakra2025-41015981,
  author  = {Abushakra, Susan R. and Power, Aidan and Watson, David and Porsteinsson, Anton P. and Sabbagh, Marwan and MacSweeney, Emer and Cohen, Sharon and Boada, Merçé and others},
  title   = {{Clinical Efficacy, Safety and Imaging Effects of Oral Valiltramiprosate in APOEε4/ε4 Homozygotes with Early Alzheimer’s Disease: Results of the Phase III, Randomized, Double-Blind, Placebo-Controlled, 78-Week APOLLOE4 Trial}},
  journal = {Drugs},
  year    = {2025},
  doi     = {10.1007/s40265-025-02250-5},
  pmid    = {41015981},
  url     = {https://doi.org/10.1007/s40265-025-02250-5}
}

@article{chen2025-40189473,
  author  = {Chen, Christopher and Katayama, Sadao and Lee, Jae Hong and Lee, Jun-Young and Nakagawa, Masaki and Torii, Kentaro and Ogawa, Tomoo and Dash, Amitabh and others},
  title   = {{Clarity AD: Asian regional analysis of a phase III trial of lecanemab in early Alzheimer's disease}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100160},
  pmid    = {40189473},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100160}
}

@article{kehinde2025-40725274,
  author  = {Kehinde, S. A. and Lin, W. P. and Lay, B. B. and Phyo, K. Y. and San, M. M. and Pattanayaiying, R. and Chusri, S.},
  title   = {{Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26147026},
  pmid    = {40725274},
  url     = {https://doi.org/10.3390/ijms26147026}
}

@article{kupiec2026-41500915,
  author  = {Kupiec, J. W. and Porsteinsson, A. P. and Turner, R. S. and Hendrix, S. and Mallinckrodt, C. and Khan, A. and Cohen, I. and Liss, J. and others},
  title   = {{Phase 3 randomized clinical trials of simufilam in mild-to-moderate Alzheimer's disease}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2026},
  doi     = {10.1016/j.tjpad.2025.100469},
  pmid    = {41500915},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100469}
}

@article{bianchi2026-42613673,
  author  = {Bianchi, Federica and Broers, Barbara and Desmeules, Jules Alexandre and Langlois, Angeline and Wampfler, James and Curtin, François and Pautex, Sophie},
  title   = {{A randomised, double-blind, placebo-controlled crossover trial on cannabinoid-based medication for behavioural disorders in old patients with severe dementia: the study results}},
  journal = {Age and ageing},
  year    = {2026},
  doi     = {10.1093/ageing/afag239},
  pmid    = {42613673},
  url     = {https://doi.org/10.1093/ageing/afag239}
}

@article{portron2020-31883703,
  author  = {Portron, A. and Jordan, P. and Draper, K. and Muenzer, C. and Dickerson, D. and van Iersel, T. and Hofmann, C.},
  title   = {{A Phase I Study to Assess the Effect of Speed of Injection on Pain, Tolerability, and Pharmacokinetics After High-volume Subcutaneous Administration of Gantenerumab in Healthy Volunteers}},
  journal = {Clinical therapeutics},
  year    = {2020},
  doi     = {10.1016/j.clinthera.2019.11.015},
  pmid    = {31883703},
  url     = {https://doi.org/10.1016/j.clinthera.2019.11.015}
}

@article{ghorat2024-38069542,
  author  = {Ghorat, F. and Sepidarkish, M. and Saadattalab, F. and Rezghi, M. and Shahrestani, S. and Gholamalizadeh, M. and Doaei, S.},
  title   = {{The clinical efficacy of Olibanum gum chewing in patients with Mild-to-Moderate Alzheimer disease: A randomized Parallel-Design controlled trial}},
  journal = {Neuropsychopharmacology reports},
  year    = {2024},
  doi     = {10.1002/npr2.12398},
  pmid    = {38069542},
  url     = {https://doi.org/10.1002/npr2.12398}
}

@article{andersen2011-21970467,
  author  = {Andersen, F. and Viitanen, M. and Halvorsen, D. S. and Straume, B. and Engstad, T. A.},
  title   = {{Co-morbidity and drug treatment in Alzheimer's disease. A cross sectional study of participants in the dementia study in northern Norway}},
  journal = {BMC geriatrics},
  year    = {2011},
  doi     = {10.1186/1471-2318-11-58},
  pmid    = {21970467},
  url     = {https://doi.org/10.1186/1471-2318-11-58}
}

@article{koch2025-40176122,
  author  = {Koch, Giacomo and Casula, Elias Paolo and Bonnı̀, Sonia and Borghi, Ilaria and Assogna, Martina and Di Lorenzo, Francesco and Esposito, Romina and Maiella, Michele and others},
  title   = {{Effects of 52 weeks of precuneus rTMS in Alzheimer’s disease patients: a randomized trial}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01709-7},
  pmid    = {40176122},
  url     = {https://doi.org/10.1186/s13195-025-01709-7}
}

@article{krishnan2009-19370677,
  author  = {Krishnan, S. and Cairns, R. and Howard, R.},
  title   = {{Cannabinoids for the treatment of dementia}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2009},
  doi     = {10.1002/14651858.cd007204.pub2},
  pmid    = {19370677},
  url     = {https://doi.org/10.1002/14651858.cd007204.pub2}
}

@article{roman2010-20395618,
  author  = {Román, G. C. and Salloway, S. and Black, S. E. and Royall, D. R. and Decarli, C. and Weiner, M. W. and Moline, M. and Kumar, D. and others},
  title   = {{Randomized, placebo-controlled, clinical trial of donepezil in vascular dementia: differential effects by hippocampal size}},
  journal = {Stroke},
  year    = {2010},
  doi     = {10.1161/strokeaha.109.570077},
  pmid    = {20395618},
  url     = {https://doi.org/10.1161/strokeaha.109.570077}
}

@article{jyvakorpi2012-22624652,
  author  = {Jyvakorpi, S. K. and Puranen, T. and Pitkala, K. H. and Suominen, M. H.},
  title   = {{Nutritional treatment of aged individuals with Alzheimer disease living at home with their spouses: study protocol for a randomized controlled trial}},
  journal = {Trials},
  year    = {2012},
  doi     = {10.1186/1745-6215-13-66},
  pmid    = {22624652},
  url     = {https://doi.org/10.1186/1745-6215-13-66}
}

@article{chhetri2018-29405230,
  author  = {Chhetri, J. K. and de Souto Barreto, P. and Cantet, C. and Cesari, M. and Coley, N. and Andrieu, S. and Vellas, B.},
  title   = {{Trajectory of the MAPT-PACC-Preclinical Alzheimer Cognitive Composite in the Placebo Group of a Randomized Control Trial: Results from the MAPT Study: Lessons for Further Trials}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2018},
  doi     = {10.14283/jpad.2017.21},
  pmid    = {29405230},
  url     = {https://doi.org/10.14283/jpad.2017.21}
}

@article{caramelli2014-24964105,
  author  = {Caramelli, P. and Laks, J. and Palmini, A. L. and Nitrini, R. and Chaves, M. L. and Forlenza, O. V. and Vale Fde, A. and Barbosa, M. T. and others},
  title   = {{Effects of galantamine and galantamine combined with nimodipine on cognitive speed and quality of life in mixed dementia: a 24-week, randomized, placebo-controlled exploratory trial (the REMIX study)}},
  journal = {Arquivos de neuro-psiquiatria},
  year    = {2014},
  doi     = {10.1590/0004-282x20140055},
  pmid    = {24964105},
  url     = {https://doi.org/10.1590/0004-282x20140055}
}

@article{devanand2012-21407047,
  author  = {Devanand, D. P. and Mintzer, J. and Schultz, S. and Sultzer, D. and de la Pena, D. and Gupta, S. and Colon, S. and Schimming, C. and others},
  title   = {{The antipsychotic discontinuation in Alzheimer disease trial: clinical rationale and study design}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2012},
  doi     = {10.1097/jgp.0b013e3182110563},
  pmid    = {21407047},
  url     = {https://doi.org/10.1097/jgp.0b013e3182110563}
}

@article{doraiswamy2014-24614494,
  author  = {Doraiswamy, P. M. and Sperling, R. A. and Johnson, K. and Reiman, E. M. and Wong, T. Z. and Sabbagh, M. N. and Sadowsky, C. H. and Fleisher, A. S. and others},
  title   = {{Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study}},
  journal = {Molecular psychiatry},
  year    = {2014},
  doi     = {10.1038/mp.2014.9},
  pmid    = {24614494},
  url     = {https://doi.org/10.1038/mp.2014.9}
}

@article{yeon2025-40696527,
  author  = {Yeon, Jeon So and Sheng-Min, Wang and Woong, Roh Hyun and You, Kim Keun and Young, Chang Yoon and Eosu, Kim and Jae-Nam, Bae and Seung-Ho, Ryu},
  title   = {{Practical Guide of the Korean Association for Geriatric Psychiatry to Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer's Disease: Focused on Lecanemab}},
  journal = {Journal of Korean medical science},
  year    = {2025},
  doi     = {10.3346/jkms.2025.40.e215},
  pmid    = {40696527},
  url     = {https://doi.org/10.3346/jkms.2025.40.e215}
}

@article{haroon2024-39058809,
  author  = {Haroon, J. and Jordan, K. and Mahdavi, K. and Rindner, E. and Becerra, S. and Surya, JR. and Zielinski, M. and Venkatraman, V. and others},
  title   = {{A phase 2, open-label study of anti-inflammatory NE3107 in patients with dementias}},
  journal = {Medicine},
  year    = {2024},
  doi     = {10.1097/md.0000000000039027},
  pmid    = {39058809},
  url     = {https://doi.org/10.1097/md.0000000000039027}
}

@article{leoutsakos2018-29914028,
  author  = {Leoutsakos, J. S. and Yan, H. and Anderson, W. S. and Asaad, W. F. and Baltuch, G. and Burke, A. and Chakravarty, M. M. and Drake, K. E. and others},
  title   = {{Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-180121},
  pmid    = {29914028},
  url     = {https://doi.org/10.3233/jad-180121}
}

@article{scholz2018-30333067,
  author  = {Scholz, R. and Lemcke, J. and Meier, U. and Stengel, D.},
  title   = {{Efficacy and safety of programmable compared with fixed anti-siphon devices for treating idiopathic normal-pressure hydrocephalus (iNPH) in adults - SYGRAVA: study protocol for a randomized trial}},
  journal = {Trials},
  year    = {2018},
  doi     = {10.1186/s13063-018-2951-6},
  pmid    = {30333067},
  url     = {https://doi.org/10.1186/s13063-018-2951-6}
}

@article{silveira2019-30738426,
  author  = {Silveira, C. R. A. and MacKinley, J. and Coleman, K. and Li, Z. and Finger, E. and Bartha, R. and Morrow, S. A. and Wells, J. and others},
  title   = {{Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial}},
  journal = {BMC neurology},
  year    = {2019},
  doi     = {10.1186/s12883-019-1252-3},
  pmid    = {30738426},
  url     = {https://doi.org/10.1186/s12883-019-1252-3}
}

@article{vangils2026-41508135,
  author  = {van Gils, Veerle and Waterink, Lisa and Wimmers, S. C. P. M. and Jelsma, J.G.M. and de Vugt, Marjolein Elizabeth and Handels, Ron L. H. and Sikkes, Sietske A.M. and van der Flier, Wiesje M. and others},
  title   = {{The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-025-01947-9},
  pmid    = {41508135},
  url     = {https://doi.org/10.1186/s13195-025-01947-9}
}

@article{scheuermann2025-40306986,
  author  = {Scheuermann, Julia-Sophia and Scheerbaum, Petra and Liu, Yu and Ding, Yaping and Lu, Jianwen and Zhong, Ming and Su, Jian and Gefeller, Olaf and others},
  title   = {{SinoMAKS—protocol of a randomised controlled trial to evaluate the Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementia in Chinese nursing homes}},
  journal = {BMJ Open},
  year    = {2025},
  doi     = {10.1136/bmjopen-2024-093618},
  pmid    = {40306986},
  url     = {https://doi.org/10.1136/bmjopen-2024-093618}
}

@article{wang2020-32920628,
  author  = {Wang, H. Y. and Pei, Z. and Lee, K. C. and Lopez-Brignoni, E. and Nikolov, B. and Crowley, C. A. and Marsman, M. R. and Barbier, R. and others},
  title   = {{PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2020},
  doi     = {10.14283/jpad.2020.6},
  pmid    = {32920628},
  url     = {https://doi.org/10.14283/jpad.2020.6}
}

@article{hopkinson2026-42302797,
  author  = {Hopkinson, Olivia K and Chobanov, Jan and Goordeen, Darshna and Man, Kenneth K C and Wong, Ian C K and Reeve, Emily and Bell, J Simon and Wei, Li and others},
  title   = {{Abrupt discontinuation and tapering of antipsychotics in older adults with dementia: a target trial emulation study}},
  journal = {The lancet. Healthy longevity},
  year    = {2026},
  doi     = {10.1016/j.lanhl.2026.100852},
  pmid    = {42302797},
  url     = {https://doi.org/10.1016/j.lanhl.2026.100852}
}

@article{albertini2026-41286448,
  author  = {Albertini, G. and Zielonka, M. and Cuypers, M. L. and Snellinx, A. and Xu, C. and Poovathingal, S. and Wojno, M. and Davie, K. and van Lieshout, V. and Craessaerts, K. and Wolfs, L. and Pasciuto, E. and others},
  title   = {{The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia}},
  journal = {Nature Neuroscience},
  year    = {2026},
  doi     = {10.1038/s41593-025-02125-8},
  pmid    = {41286448},
  url     = {https://doi.org/10.1038/s41593-025-02125-8}
}

@article{chow2007-19300592,
  author  = {Chow, T. W. and Pollock, B. G. and Milgram, N. W.},
  title   = {{Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease}},
  journal = {Neuropsychiatric disease and treatment},
  year    = {2007},
  pmid    = {19300592}
}

@article{peters2016-26303700,
  author  = {Peters, M. E. and Vaidya, V. and Drye, L. T. and Devanand, D. P. and Mintzer, J. E. and Pollock, B. G. and Porsteinsson, A. P. and Rosenberg, P. B. and others},
  title   = {{Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences}},
  journal = {Journal of geriatric psychiatry and neurology},
  year    = {2016},
  doi     = {10.1177/0891988715601735},
  pmid    = {26303700},
  url     = {https://doi.org/10.1177/0891988715601735}
}

@article{li2017-29390538,
  author  = {Li, M. and Lyu, J. H. and Zhang, Y. and Gao, M. L. and Li, W. J. and Ma, X.},
  title   = {{The clinical efficacy of reminiscence therapy in patients with mild-to-moderate Alzheimer disease: Study protocol for a randomized parallel-design controlled trial}},
  journal = {Medicine},
  year    = {2017},
  doi     = {10.1097/md.0000000000009381},
  pmid    = {29390538},
  url     = {https://doi.org/10.1097/md.0000000000009381}
}

@article{ross2022-35344024,
  author  = {Ross, E. L. and Weinberg, M. S. and Arnold, S. E.},
  title   = {{Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.0315},
  pmid    = {35344024},
  url     = {https://doi.org/10.1001/jamaneurol.2022.0315}
}

@article{bayer2005-15642910,
  author  = {Bayer, A. J. and Bullock, R. and Jones, R. W. and Wilkinson, D. and Paterson, K. R. and Jenkins, L. and Millais, S. B. and Donoghue, S.},
  title   = {{Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000148604.77591.67},
  pmid    = {15642910},
  url     = {https://doi.org/10.1212/01.wnl.0000148604.77591.67}
}

@article{fassbender2001-11296263,
  author  = {Fassbender, K. and Simons, M. and Bergmann, C. and Stroick, M. and Lutjohann, D. and Keller, P. and Runz, H. and Kuhl, S. and others},
  title   = {{Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2001},
  doi     = {10.1073/pnas.081620098},
  pmid    = {11296263},
  url     = {https://doi.org/10.1073/pnas.081620098}
}

@article{nygaard2015-25874001,
  author  = {Nygaard, H. B. and Wagner, A. F. and Bowen, G. S. and Good, S. P. and MacAvoy, M. G. and Strittmatter, K. A. and Kaufman, A. C. and Rosenberg, B. J. and others},
  title   = {{A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2015},
  doi     = {10.1186/s13195-015-0119-0},
  pmid    = {25874001},
  url     = {https://doi.org/10.1186/s13195-015-0119-0}
}

@article{deane2012-22406537,
  author  = {Deane, R. and Singh, I. and Sagare, A. P. and Bell, R. D. and Ross, N. T. and LaRue, B. and Love, R. and Perry, S. and others},
  title   = {{A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2012},
  doi     = {10.1172/jci58642},
  pmid    = {22406537},
  url     = {https://doi.org/10.1172/jci58642}
}

@article{rivasi2025-40067602,
  author  = {Rivasi, Giulia and Capacci, Marco and Del Re, Lorenzo Maria and Ambrosino, Ilaria and Ceolin, Ludovica and Liccardo, Alessandra and Bisignano, Maria Francesca and D’Ambrosio, Giuseppe and others},
  title   = {{Trazodone and Risk of Orthostatic Hypotension, Syncope and Falls in Geriatric Outpatients with Hypertension}},
  journal = {Drugs \& Aging},
  year    = {2025},
  doi     = {10.1007/s40266-025-01196-3},
  pmid    = {40067602},
  url     = {https://doi.org/10.1007/s40266-025-01196-3}
}

@article{ruthirakuhan2026-42178577,
  author  = {Ruthirakuhan, M. and Mills, M. and Rosenberg, P. and Haughey, N. and Mintzer, J. and Brawman-Mintzer, O. and Craft, S. and Herrmann, N. and others},
  title   = {{Uncovering lipid biomarkers linked to methylphenidate efficacy in treating apathy in Alzheimer's disease: insights from the ADMET 2 trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-02055-y},
  pmid    = {42178577},
  url     = {https://doi.org/10.1186/s13195-026-02055-y}
}

@article{rubright2010-20808101,
  author  = {Rubright, J. and Sankar, P. and Casarett, D. J. and Gur, R. and Xie, S. X. and Karlawish, J.},
  title   = {{A memory and organizational aid improves Alzheimer disease research consent capacity: results of a randomized, controlled trial}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2010},
  doi     = {10.1097/jgp.0b013e3181dd1c3b},
  pmid    = {20808101},
  url     = {https://doi.org/10.1097/jgp.0b013e3181dd1c3b}
}

@article{schneider2019-31282954,
  author  = {Schneider, L. S. and Thomas, R. G. and Hendrix, S. and Rissman, R. A. and Brewer, J. B. and Salmon, D. P. and Oltersdorf, T. and Okuda, T. and others},
  title   = {{Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2019.1868},
  pmid    = {31282954},
  url     = {https://doi.org/10.1001/jamaneurol.2019.1868}
}

@article{lee2020-32872063,
  author  = {Lee, J. and Jin, C. and Cho, S. Y. and Park, S. U. and Jung, W. S. and Moon, S. K. and Park, J. M. and Ko, C. N. and others},
  title   = {{Herbal medicine treatment for Alzheimer disease: A protocol for a systematic review and meta-analysis}},
  journal = {Medicine},
  year    = {2020},
  doi     = {10.1097/md.0000000000021745},
  pmid    = {32872063},
  url     = {https://doi.org/10.1097/md.0000000000021745}
}

@article{bloniecki2017-28269767,
  author  = {Bloniecki, V. and Aarsland, D. and Blennow, K. and Cummings, J. and Falahati, F. and Winblad, B. and Freund-Levi, Y.},
  title   = {{Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160758},
  pmid    = {28269767},
  url     = {https://doi.org/10.3233/jad-160758}
}

@article{sun2012-25657666,
  author  = {Sun, Y. and Wang, G. and Pan, Z. and Chen, S.},
  title   = {{Systematic review of atorvastatin for the treatment of Alzheimer's disease}},
  journal = {Neural regeneration research},
  year    = {2012},
  doi     = {10.3969/j.issn.1673-5374.2012.17.010},
  pmid    = {25657666},
  url     = {https://doi.org/10.3969/j.issn.1673-5374.2012.17.010}
}

@article{han2019-30633043,
  author  = {Han, J. Y. and Besser, L. M. and Xiong, C. and Kukull, W. A. and Morris, J. C.},
  title   = {{Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2019},
  doi     = {10.1097/wad.0000000000000291},
  pmid    = {30633043},
  url     = {https://doi.org/10.1097/wad.0000000000000291}
}

@article{njamnshi2025-41395729,
  author  = {Njamnshi, Wepnyu Yembe and Chiotis, Konstantinos and Tsoy, Elena and Blazhenets, Ganna and Maiti, Piyush and Zhang, Jiaxiuxiu and Allen, Isabel Elaine and Rocha, Salma and others},
  title   = {{Tablet‐based Cognitive Assessment Tool (TabCAT) in a multisite study of early‐onset Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.71012},
  pmid    = {41395729},
  url     = {https://doi.org/10.1002/alz.71012}
}

@article{wang2025-40552638,
  author  = {Wang, William and Davis, Pamela B. and Qi, Xin and Gurney, Mark E. and Perry, George and Volkow, Nora D. and Kaelber, David C. and Xu, Rong},
  title   = {{Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251351329},
  pmid    = {40552638},
  url     = {https://doi.org/10.1177/13872877251351329}
}

@article{galvin2025-41416579,
  author  = {Galvin, James E. and Tolea, Magdalena I. and Scharre, Douglas W. and Hamby, Mary E. and Iaci, Jennifer F. and Grundman, Michael and Caggiano, Anthony O.},
  title   = {{Phase 2 study of zervimesine (CT1812) in participants with mild‐to‐moderate dementia with Lewy bodies (DLB)}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.71004},
  pmid    = {41416579},
  url     = {https://doi.org/10.1002/alz.71004}
}

@article{voigt2023-37277877,
  author  = {Voigt, S. and Koemans, E. A. and Rasing, I. and van Etten, E. S. and Terwindt, G. M. and Baas, F. and Kaushik, K. and van Es, A. C. G. M. and others},
  title   = {{Minocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): study protocol for a placebo-controlled randomized double-blind trial}},
  journal = {Trials},
  year    = {2023},
  doi     = {10.1186/s13063-023-07371-4},
  pmid    = {37277877},
  url     = {https://doi.org/10.1186/s13063-023-07371-4}
}

@article{skvarc2016-27502769,
  author  = {Skvarc, D. R. and Dean, O. M. and Byrne, L. K. and Gray, L. J. and Ives, K. and Lane, S. E. and Lewis, M. and Osborne, C. and others},
  title   = {{The Post-Anaesthesia N-acetylcysteine Cognitive Evaluation (PANACEA) trial: study protocol for a randomised controlled trial}},
  journal = {Trials},
  year    = {2016},
  doi     = {10.1186/s13063-016-1529-4},
  pmid    = {27502769},
  url     = {https://doi.org/10.1186/s13063-016-1529-4}
}

@article{filip1999-10354658,
  author  = {Filip, V. and Kolibás, E.},
  title   = {{Selegiline in the treatment of Alzheimer's disease: a long-term randomized placebo-controlled trial. Czech and Slovak Senile Dementia of Alzheimer Type Study Group}},
  journal = {Journal of psychiatry \& neuroscience : JPN},
  year    = {1999},
  pmid    = {10354658}
}

@article{sanchez2016-26631687,
  author  = {Sánchez, A. and Marante-Moar, M. P. and Sarabia, C. and de Labra, C. and Lorenzo, T. and Maseda, A. and Millán-Calenti, J. C.},
  title   = {{Multisensory Stimulation as an Intervention Strategy for Elderly Patients With Severe Dementia: A Pilot Randomized Controlled Trial}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2016},
  doi     = {10.1177/1533317515618801},
  pmid    = {26631687},
  url     = {https://doi.org/10.1177/1533317515618801}
}

@article{duggleby2020-32778059,
  author  = {Duggleby, W. and O'Rourke, H. and Swindle, J. and Peacock, S. and McAiney, C. and Baxter, P. and Thompson, G. and Dubé, V. and others},
  title   = {{Study protocol: pragmatic randomized control trial of my tools 4 care- in care (MT4C-in care) a web-based tool for family Carers of persons with dementia residing in long term care}},
  journal = {BMC geriatrics},
  year    = {2020},
  doi     = {10.1186/s12877-020-01690-w},
  pmid    = {32778059},
  url     = {https://doi.org/10.1186/s12877-020-01690-w}
}

@article{dwivedi2026-41740144,
  author  = {Dwivedi, A. and Anjali, A. and Narzari, H. and Kumar, Y. and Sharma, H. P. and Dubey, A. and Nilima, N. and Rajan, R. and others},
  title   = {{Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment and Early Alzheimer Disease: Protocol for an Exploratory Double-Blind, Randomized, Placebo-Controlled Trial}},
  journal = {JMIR research protocols},
  year    = {2026},
  doi     = {10.2196/82891},
  pmid    = {41740144},
  url     = {https://doi.org/10.2196/82891}
}

@article{wright2025-40146982,
  author  = {Wright, K. D. and Richards Adams, I. K. and Helsabeck, N. P. and Rose, K. M. and Moss, K. O. and Nemati, D. and Palmer, N. and Kim, B. and others},
  title   = {{Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial}},
  journal = {JMIR research protocols},
  year    = {2025},
  doi     = {10.2196/66975},
  pmid    = {40146982},
  url     = {https://doi.org/10.2196/66975}
}

@article{sun2025-40695613,
  author  = {Sun, Mingyang and Wang, Xiaoling and Lu, Zhongyuan and Yang, Yi and Lv, Shuang and Miao, Mengrong and Chen, Wanming and Wu, Szu‐Yuan and others},
  title   = {{Evaluating GLP-1 receptor agonists versus metformin as first-line therapy for reducing dementia risk in type 2 diabetes}},
  journal = {BMJ Open Diabetes Research \& Care},
  year    = {2025},
  doi     = {10.1136/bmjdrc-2025-004902},
  pmid    = {40695613},
  url     = {https://doi.org/10.1136/bmjdrc-2025-004902}
}

@article{roach2025-41275266,
  author  = {Roach, Jared C. and Glusman, Gwênlyn and Rapozo, Molly K. and Merrill, David A. and Bramen, Jennifer E. and Hodes, John F. and Siddarth, Prabha and Meysami, Somayeh and others},
  title   = {{Multidomain therapy for Alzheimer’s disease: a scoping review of cognitive decline trials}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00912-2},
  pmid    = {41275266},
  url     = {https://doi.org/10.1186/s13024-025-00912-2}
}

@article{bingke2025-40489822,
  author  = {Bingke, Xing and Jingran, Yang and Hui, Hua and Rong, Jiang},
  title   = {{Rapid health technology assessment of galantamine for the treatment of Alzheimer's disease: A review}},
  journal = {Medicine},
  year    = {2025},
  doi     = {10.1097/MD.0000000000042744},
  pmid    = {40489822},
  url     = {https://doi.org/10.1097/MD.0000000000042744}
}

@article{mcclean2011-21525299,
  author  = {McClean, P. L. and Parthsarathy, V. and Faivre, E. and Hölscher, C.},
  title   = {{The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2011},
  doi     = {10.1523/jneurosci.0529-11.2011},
  pmid    = {21525299},
  url     = {https://doi.org/10.1523/jneurosci.0529-11.2011}
}

@article{leblhuber2018-30101706,
  author  = {Leblhuber, F. and Steiner, K. and Schuetz, B. and Fuchs, D. and Gostner, J. M.},
  title   = {{Probiotic Supplementation in Patients with Alzheimer's Dementia - An Explorative Intervention Study}},
  journal = {Current Alzheimer research},
  year    = {2018},
  doi     = {10.2174/1389200219666180813144834},
  pmid    = {30101706},
  url     = {https://doi.org/10.2174/1389200219666180813144834}
}

@article{wielage2016-27326725,
  author  = {Wielage, Ronald C. and Perk, Sinem and Campbell, Noll L. and Klein, Timothy M. and Posta, Linda M. and Yuran, Thomas E. and Klein, Robert W. and Ng, Daniel},
  title   = {{Mirabegron for the treatment of overactive bladder: cost-effectiveness from US commercial health-plan and Medicare Advantage perspectives}},
  journal = {Journal of Medical Economics},
  year    = {2016},
  doi     = {10.1080/13696998.2016.1204307},
  pmid    = {27326725},
  url     = {https://doi.org/10.1080/13696998.2016.1204307}
}

@article{michaelian2025-39912236,
  author  = {Michaelian, Johannes C. and Rowe, Christopher C. and Kurrle, Susan E and Pond, Constance Dimity and Woodward, Michael and Naismith, Sharon Linda},
  title   = {{Is Australia ready for the rollout of amyloid‐targeting therapies for Alzheimer disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics}},
  journal = {Internal Medicine Journal},
  year    = {2025},
  doi     = {10.1111/imj.16637},
  pmid    = {39912236},
  url     = {https://doi.org/10.1111/imj.16637}
}

@article{sankhe2026-41521126,
  author  = {Sankhe, Krushnaa and Ruthirakuhan, Myuri T. and Andreazza, Ana C. and Brawman‐Mintzer, Olga and Craft, Suzanne and Herrmann, Nathan and Ismail, Zahinoor and Lerner, Alan J. and others},
  title   = {{Peripheral biomarkers associated with apathy and predicting response to methylphenidate: Secondary analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET2) study}},
  journal = {International Psychogeriatrics},
  year    = {2026},
  doi     = {10.1016/j.inpsyc.2025.100181},
  pmid    = {41521126},
  url     = {https://doi.org/10.1016/j.inpsyc.2025.100181}
}

@article{hunt2025-40126467,
  author  = {Hunt, Lauren J. and Gan, Siqi and Boscardin, W. John and Harrison, Krista Lyn and Growdon, Matthew E. and Muench, Ulrike and Gerlach, Lauren B. and Smith, Alexander Kingsbury and others},
  title   = {{Continued Use of Cholinesterase Inhibitors and Memantine in Hospice}},
  journal = {JAMA Internal Medicine},
  year    = {2025},
  doi     = {10.1001/jamainternmed.2024.8579},
  pmid    = {40126467},
  url     = {https://doi.org/10.1001/jamainternmed.2024.8579}
}

@article{kim2023-37403351,
  author  = {Kim, A. and Lee, J. and Moon, H. and Kim, C. and Yoo, M. Y. and Park, W. Y. and Kim, W. D. and Seo, Y. S.},
  title   = {{The effects of low-dose radiation therapy in patients with mild-to-moderate Alzheimer's dementia: an interim analysis of a pilot study}},
  journal = {Radiation oncology journal},
  year    = {2023},
  doi     = {10.3857/roj.2023.00052},
  pmid    = {37403351},
  url     = {https://doi.org/10.3857/roj.2023.00052}
}

@article{koch2025-40809903,
  author  = {Koch, G. and Assogna, M. and Gadola, Y. and Alberici, A. and Di Lorenzo, F. and Bonnì, S. and Borghi, I. and Cerulli Irelli, E. and others},
  title   = {{Safety and efficacy of rotigotine in patients with frontotemporal dementia: a phase 2, double-blind, randomized, placebo-controlled, multicenter trial}},
  journal = {The Lancet regional health. Europe},
  year    = {2025},
  doi     = {10.1016/j.lanepe.2025.101409},
  pmid    = {40809903},
  url     = {https://doi.org/10.1016/j.lanepe.2025.101409}
}

@article{zandi2004-14732624,
  author  = {Zandi, P. P. and Anthony, J. C. and Khachaturian, A. S. and Stone, S. V. and Gustafson, D. and Tschanz, J. T. and Norton, M. C. and Welsh-Bohmer, K. A. and others},
  title   = {{Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study}},
  journal = {Archives of neurology},
  year    = {2004},
  doi     = {10.1001/archneur.61.1.82},
  pmid    = {14732624},
  url     = {https://doi.org/10.1001/archneur.61.1.82}
}

@article{lopez2002-11861686,
  author  = {Lopez, O. L. and Becker, J. T. and Wisniewski, S. and Saxton, J. and Kaufer, D. I. and DeKosky, S. T.},
  title   = {{Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2002},
  doi     = {10.1136/jnnp.72.3.310},
  pmid    = {11861686},
  url     = {https://doi.org/10.1136/jnnp.72.3.310}
}

@article{bertram2026-42286243,
  author  = {Bertram, David and Ophey, Anja and Röttgen, Sinah and Kufer, Konstantin and Merten, Nele and Fink, Gereon R. and Kalbe, Elke and Hansen, Clint and others},
  title   = {{ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy}},
  journal = {npj Digital Medicine},
  year    = {2026},
  doi     = {10.1038/s41746-026-02738-8},
  pmid    = {42286243},
  url     = {https://doi.org/10.1038/s41746-026-02738-8}
}

@article{torresyaghi2025-41286676,
  author  = {Torres-Yaghi, Y. and Chrones, L. and Abler, V. and Brunson, G.},
  title   = {{Safety and efficacy of pimavanserin in patients with Lewy body dementia experiencing dementia-related psychosis in the HARMONY study}},
  journal = {BMC Neurology},
  year    = {2025},
  doi     = {10.1186/s12883-025-04496-8},
  pmid    = {41286676},
  url     = {https://doi.org/10.1186/s12883-025-04496-8}
}

@article{zhou2025-41447712,
  author  = {Zhou, Jin and Andreozzi, Erica M. and Llibre‐Guerra, Jorge J. and Clifford, David B. and Li, David and Wang, Guoqiao and Schneider, Lon S. S. and McDade, Eric and others},
  title   = {{Safety of Lecanemab After 6‐Month Treatment in the DIAN‐TU‐001 Trial}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_105304},
  pmid    = {41447712},
  url     = {https://doi.org/10.1002/alz70859_105304}
}

@article{liu2025-41568736,
  author  = {Liu, Wenying and Li, Yan and Qin, Wei and Wang, Xuechu and Li, Wenwen and Li, Ying and {Alzheimer's Disease Neuroimaging Initiative} and Jia, Jianping},
  title   = {{The impact of cholinesterase inhibitors on cognitive trajectories in mild cognitive impairment patients based on amyloid beta status}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70193},
  pmid    = {41568736},
  url     = {https://doi.org/10.1002/alz.70193}
}

@article{xia2025-40730714,
  author  = {Xia, X. and Aye, S. and Frisell, O. and Aho, E. and Handels, R. and Li, Y. and Wimo, A. and Winblad, B. and Eriksdotter, M. and Skillbäck, T. B. and Kern, S. and Zetterberg, H. and others},
  title   = {{The Cost-Effective Price of Lecanemab for Patients with Early Alzheimer's Disease in Sweden}},
  journal = {PharmacoEconomics},
  year    = {2025},
  doi     = {10.1007/s40273-025-01527-7},
  pmid    = {40730714},
  url     = {https://doi.org/10.1007/s40273-025-01527-7}
}

@article{soto2015-25226218,
  author  = {Soto, M. and Andrieu, S. and Nourhashemi, F. and Ousset, P. J. and Ballard, C. and Robert, P. and Vellas, B. and Lyketsos, C. G. and others},
  title   = {{Medication development for agitation and aggression in Alzheimer disease: review and discussion of recent randomized clinical trial design}},
  journal = {International psychogeriatrics},
  year    = {2015},
  doi     = {10.1017/s1041610214001720},
  pmid    = {25226218},
  url     = {https://doi.org/10.1017/s1041610214001720}
}

@article{marron2018-30185210,
  author  = {Marron, E. M. and Viejo-Sobera, R. and Quintana, M. and Redolar-Ripoll, D. and Rodríguez, D. and Garolera, M.},
  title   = {{Transcranial magnetic stimulation intervention in Alzheimer's disease: a research proposal for a randomized controlled trial}},
  journal = {BMC research notes},
  year    = {2018},
  doi     = {10.1186/s13104-018-3757-z},
  pmid    = {30185210},
  url     = {https://doi.org/10.1186/s13104-018-3757-z}
}

@article{goekoop2006-16251213,
  author  = {Goekoop, R. and Scheltens, P. and Barkhof, F. and Rombouts, S. A.},
  title   = {{Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study}},
  journal = {Brain : a journal of neurology},
  year    = {2006},
  doi     = {10.1093/brain/awh671},
  pmid    = {16251213},
  url     = {https://doi.org/10.1093/brain/awh671}
}

@article{gong2004-15578094,
  author  = {Gong, B. and Vitolo, O. V. and Trinchese, F. and Liu, S. and Shelanski, M. and Arancio, O.},
  title   = {{Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment}},
  journal = {The Journal of clinical investigation},
  year    = {2004},
  doi     = {10.1172/jci22831},
  pmid    = {15578094},
  url     = {https://doi.org/10.1172/jci22831}
}

@article{sveikata2022-34905943,
  author  = {Sveikata, L. and Charidimou, A. and Viswanathan, A.},
  title   = {{Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab}},
  journal = {Stroke},
  year    = {2022},
  doi     = {10.1161/strokeaha.121.036873},
  pmid    = {34905943},
  url     = {https://doi.org/10.1161/strokeaha.121.036873}
}

@article{maczurek2008-18655815,
  author  = {Maczurek, A. and Hager, K. and Kenklies, M. and Sharman, M. and Martins, R. and Engel, J. and Carlson, D. A. and Münch, G.},
  title   = {{Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease}},
  journal = {Advanced drug delivery reviews},
  year    = {2008},
  doi     = {10.1016/j.addr.2008.04.015},
  pmid    = {18655815},
  url     = {https://doi.org/10.1016/j.addr.2008.04.015}
}

@article{saltmarche2017-28186867,
  author  = {Saltmarche, A. E. and Naeser, M. A. and Ho, K. F. and Hamblin, M. R. and Lim, L.},
  title   = {{Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report}},
  journal = {Photomedicine and laser surgery},
  year    = {2017},
  doi     = {10.1089/pho.2016.4227},
  pmid    = {28186867},
  url     = {https://doi.org/10.1089/pho.2016.4227}
}

@article{wildsmith2025-41447716,
  author  = {Wildsmith, Kristin R. and Charil, Arnaud and Benzinger, Tammie L.S. and Gordon, Brian Andrew and Bhagunde, Pratik R. and Li, David and Wang, Guoqiao and Reyderman, Larisa and others},
  title   = {{Lecanemab in DIAD: 6‐Month Amyloid PET Results from the DIAN‐TU‐001 Trial}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_105303},
  pmid    = {41447716},
  url     = {https://doi.org/10.1002/alz70859_105303}
}

@article{chen2025-40459787,
  author  = {Chen, Charles D. and Franklin, Erin E. and Li, Yan and Joseph‐Mathurin, Nelly and Burns, Aime and Hobbs, Diana A. and McCullough, Austin A. and Schultz, Stephanie A. and others},
  title   = {{Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease}},
  journal = {Acta Neuropathologica},
  year    = {2025},
  doi     = {10.1007/s00401-025-02890-7},
  pmid    = {40459787},
  url     = {https://doi.org/10.1007/s00401-025-02890-7}
}

@article{mao2026-41520099,
  author  = {Mao, Chenhui and Wang, Wenjun and Huang, Xinying and Wu, Meiqi and Wang, Yifei and Wang, Tianyi and Qiu, Yuyue and Chu, Shanshan and others},
  title   = {{Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-025-01943-z},
  pmid    = {41520099},
  url     = {https://doi.org/10.1186/s13195-025-01943-z}
}

@article{zimmer2025-41330788,
  author  = {Zimmer, Jennifer A. and Sims, John R. and Evans, Cynthia Duggan and Nery, Emel Serap Monkul and Wang, Hong and Wessels, Alette M. and Tronchin, Giulia and Sato, Shoichiro and others},
  title   = {{Donanemab in early symptomatic Alzheimer’s disease: results from the TRAILBLAZER-ALZ 2 long-term extension}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100446},
  pmid    = {41330788},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100446}
}

@article{qu2026-41907844,
  author  = {Qu, G. and Bi, Y. and Wang, L. and Xu, L. and Zhang, Y. and Ma, Y. and Tian, C. and Zhang, Z.},
  title   = {{Efficacy of Dang Gui Shao Yao San in treating vascular dementia in animal models: a systematic review and meta-analysis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2026},
  doi     = {10.3389/fnagi.2026.1701536},
  pmid    = {41907844},
  url     = {https://doi.org/10.3389/fnagi.2026.1701536}
}

@article{knopman2023-36948153,
  author  = {Knopman, D. S.},
  title   = {{Lecanemab reduces brain amyloid-β and delays cognitive worsening}},
  journal = {Cell reports. Medicine},
  year    = {2023},
  doi     = {10.1016/j.xcrm.2023.100982},
  pmid    = {36948153},
  url     = {https://doi.org/10.1016/j.xcrm.2023.100982}
}

@article{moussavi2021-33416500,
  author  = {Moussavi, Z. and Rutherford, G. and Lithgow, B. and Millikin, C. and Modirrousta, M. and Mansouri, B. and Wang, X. and Omelan, C. and others},
  title   = {{Repeated Transcranial Magnetic Stimulation for Improving Cognition in Patients With Alzheimer Disease: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial}},
  journal = {JMIR research protocols},
  year    = {2021},
  doi     = {10.2196/25144},
  pmid    = {33416500},
  url     = {https://doi.org/10.2196/25144}
}

@article{pasquini2022-36367770,
  author  = {Pasquini, S. and Margaritini, A. and Gambella, E. and Di Rosa, M. and Maranesi, E. and Bevilacqua, R. and Civerchia, P. and Pelliccioni, G.},
  title   = {{A Psychosocial Intervention for Supporting Informal Caregivers of Older People With Alzheimer Disease: Protocol for the InnFamiglia Randomized Controlled Trial}},
  journal = {JMIR research protocols},
  year    = {2022},
  doi     = {10.2196/37496},
  pmid    = {36367770},
  url     = {https://doi.org/10.2196/37496}
}

@article{oules2012-22915123,
  author  = {Oulès, B. and Del Prete, D. and Greco, B. and Zhang, X. and Lauritzen, I. and Sevalle, J. and Moreno, S. and Paterlini-Bréchot, P. and others},
  title   = {{Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.0875-12.2012},
  pmid    = {22915123},
  url     = {https://doi.org/10.1523/jneurosci.0875-12.2012}
}

@article{vitek2023-36749830,
  author  = {Vitek, G. E. and Decourt, B. and Sabbagh, M. N.},
  title   = {{Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease}},
  journal = {Expert opinion on investigational drugs},
  year    = {2023},
  doi     = {10.1080/13543784.2023.2178414},
  pmid    = {36749830},
  url     = {https://doi.org/10.1080/13543784.2023.2178414}
}

@article{holscher2024-38677445,
  author  = {Hölscher, C.},
  title   = {{Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?}},
  journal = {Neuropharmacology},
  year    = {2024},
  doi     = {10.1016/j.neuropharm.2024.109952},
  pmid    = {38677445},
  url     = {https://doi.org/10.1016/j.neuropharm.2024.109952}
}

@article{shippy2020-32958021,
  author  = {Shippy, D. C. and Wilhelm, C. and Viharkumar, P. A. and Raife, T. J. and Ulland, T. K.},
  title   = {{β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01948-5},
  pmid    = {32958021},
  url     = {https://doi.org/10.1186/s12974-020-01948-5}
}

@article{fonseca2009-19561098,
  author  = {Fonseca, M. I. and Ager, R. R. and Chu, S. H. and Yazan, O. and Sanderson, S. D. and LaFerla, F. M. and Taylor, S. M. and Woodruff, T. M. and others},
  title   = {{Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2009},
  doi     = {10.4049/jimmunol.0901005},
  pmid    = {19561098},
  url     = {https://doi.org/10.4049/jimmunol.0901005}
}

@article{chen2012-23122958,
  author  = {Chen, R. and Zhang, J. and Wu, Y. and Wang, D. and Feng, G. and Tang, Y. P. and Teng, Z. and Chen, C.},
  title   = {{Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease}},
  journal = {Cell reports},
  year    = {2012},
  doi     = {10.1016/j.celrep.2012.09.030},
  pmid    = {23122958},
  url     = {https://doi.org/10.1016/j.celrep.2012.09.030}
}

@article{demr2026-42784125,
  author  = {Demır, Ülkü Figen and Dilbaz, Fatmanur Karakuş},
  title   = {{Anti-Amyloid Monoclonal Antibodies in Early Alzheimer Disease: Lecanemab and Donanemab}},
  journal = {Neurology International},
  year    = {2026},
  doi     = {10.3390/neurolint18090171},
  pmid    = {42784125},
  url     = {https://doi.org/10.3390/neurolint18090171}
}

@article{li2025-41292493,
  author  = {Li, Yan and Liu, Wenying and Wang, Xuechu and Qin, Wei and Liu, Zhaojun and Lyu, Diyang and Li, Ying and Li, Bingqiu and others},
  title   = {{Effect of SSRIs on clinical progression in amnestic mild cognitive impairment stratified by Alzheimer's disease pathology}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70946},
  pmid    = {41292493},
  url     = {https://doi.org/10.1002/alz.70946}
}

@article{tian2017-28596794,
  author  = {Tian, J. and Shi, J. and Li, T. and Li, L. and Wang, Z. and Li, X. and Lv, Z. and Zheng, Q. and others},
  title   = {{Efficacy and Safety of an Herbal Therapy in Patients with Amnestic Mild Cognitive Impairment: A 24-Week Randomized Phase III Trial}},
  journal = {Evidence-based complementary and alternative medicine : eCAM},
  year    = {2017},
  doi     = {10.1155/2017/4251747},
  pmid    = {28596794},
  url     = {https://doi.org/10.1155/2017/4251747}
}

@article{noh2026-42676462,
  author  = {Noh, M. Y. and Sung, W. and Kim, H. and Son, B. and Kim, Y. E. and Choi, Y. Y. and Holtzman, D. M. and Kim, S. H.},
  title   = {{Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2026},
  doi     = {10.1002/dad2.70468},
  pmid    = {42676462},
  url     = {https://doi.org/10.1002/dad2.70468}
}

@article{leinenga2021-33836798,
  author  = {Leinenga, G. and Koh, W. K. and Götz, J.},
  title   = {{A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00809-4},
  pmid    = {33836798},
  url     = {https://doi.org/10.1186/s13195-021-00809-4}
}

@article{aso2013-23515018,
  author  = {Aso, E. and Juvés, S. and Maldonado, R. and Ferrer, I.},
  title   = {{CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2013},
  doi     = {10.3233/jad-130137},
  pmid    = {23515018},
  url     = {https://doi.org/10.3233/jad-130137}
}

@article{aso2014-24634659,
  author  = {Aso, E. and Ferrer, I.},
  title   = {{Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic}},
  journal = {Frontiers in pharmacology},
  year    = {2014},
  doi     = {10.3389/fphar.2014.00037},
  pmid    = {24634659},
  url     = {https://doi.org/10.3389/fphar.2014.00037}
}

@article{yu2025-40840993,
  author  = {Yu, Congcong and Yang, Huijie and Zhang, Bing and Chen, Shihua and Yang, Sijue and Li, Fangyi and Zhu, Wenhui and Zhai, Beibei and others},
  title   = {{Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase}},
  journal = {BMJ Open},
  year    = {2025},
  doi     = {10.1136/bmjopen-2024-095382},
  pmid    = {40840993},
  url     = {https://doi.org/10.1136/bmjopen-2024-095382}
}

@article{reinhardt2018-29358714,
  author  = {Reinhardt, S. and Stoye, N. and Luderer, M. and Kiefer, F. and Schmitt, U. and Lieb, K. and Endres, K.},
  title   = {{Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks}},
  journal = {Scientific reports},
  year    = {2018},
  doi     = {10.1038/s41598-018-19577-7},
  pmid    = {29358714},
  url     = {https://doi.org/10.1038/s41598-018-19577-7}
}

@article{gao2026-42015793,
  author  = {Gao, Lan and Watson, Rosie and Yassi, Nawaf},
  title   = {{Cost-Effectiveness of Donanemab for Early Alzheimer Disease in Australia}},
  journal = {The Medical journal of Australia},
  year    = {2026},
  doi     = {10.5694/mja2.70186},
  pmid    = {42015793},
  url     = {https://doi.org/10.5694/mja2.70186}
}

@article{marin2022-36094804,
  author  = {Marin, A. and DeCaro, R. and Schiloski, K. and Elshaar, A. and Dwyer, B. and Vives-Rodriguez, A. and Palumbo, R. and Turk, K. and others},
  title   = {{Home-Based Electronic Cognitive Therapy in Patients With Alzheimer Disease: Feasibility Randomized Controlled Trial}},
  journal = {JMIR formative research},
  year    = {2022},
  doi     = {10.2196/34450},
  pmid    = {36094804},
  url     = {https://doi.org/10.2196/34450}
}

@article{rountree2009-19845950,
  author  = {Rountree, S. D. and Chan, W. and Pavlik, V. N. and Darby, E. J. and Siddiqui, S. and Doody, R. S.},
  title   = {{Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2009},
  doi     = {10.1186/alzrt7},
  pmid    = {19845950},
  url     = {https://doi.org/10.1186/alzrt7}
}

@article{wang2017-29067332,
  author  = {Wang, C. Y. and Wang, P. N. and Chiu, M. J. and Finstad, C. L. and Lin, F. and Lynn, S. and Tai, Y. H. and De Fang, X. and others},
  title   = {{UB-311, a novel UBITh® amyloid β peptide vaccine for mild Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2017},
  doi     = {10.1016/j.trci.2017.03.005},
  pmid    = {29067332},
  url     = {https://doi.org/10.1016/j.trci.2017.03.005}
}

@article{shamrok2025-41434629,
  author  = {Shamrok, Hanadi and Davidy, Tal and Yore, Iscka and Niv, Tal and Yaffe, Tali C and Ravona‐Springer, Ramit and Livny, Abigail and Lesman‐Segev, Orit H. and others},
  title   = {{Combination of Intranasal insulin and oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_102127},
  pmid    = {41434629},
  url     = {https://doi.org/10.1002/alz70860_102127}
}

@article{kang2025-41069006,
  author  = {Kang, Wenyan and Gao, Chao and Li, Xiaoyan and Wang, Xiaoxue and Zhong, Huizhu and Wei, Qiao and Tang, Yonghua and Huang, Peijian and others},
  title   = {{Safety and effectiveness of lecanemab in Chinese patients with early Alzheimer’s disease: Evidence from a multidimensional real-world study}},
  journal = {Chinese Medical Journal},
  year    = {2025},
  doi     = {10.1097/cm9.0000000000003888},
  pmid    = {41069006},
  url     = {https://doi.org/10.1097/cm9.0000000000003888}
}

@article{bhogal2025-40404684,
  author  = {Bhogal, Inderjeet and Pankaj, Vaishali and Roy, Sudeep},
  title   = {{Identifying RAGE inhibitors as potential therapeutics for Alzheimer’s disease via integrated in-silico approaches}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-01271-0},
  pmid    = {40404684},
  url     = {https://doi.org/10.1038/s41598-025-01271-0}
}

@article{chao2005-15668426,
  author  = {Chao, L. L. and Schuff, N. and Kramer, J. H. and Du, A. T. and Capizzano, A. A. and O'Neill, J. and Wolkowitz, O. M. and Jagust, W. J. and others},
  title   = {{Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000149638.45635.ff},
  pmid    = {15668426},
  url     = {https://doi.org/10.1212/01.wnl.0000149638.45635.ff}
}

@article{lilienfeld2002-12177686,
  author  = {Lilienfeld, S.},
  title   = {{Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease}},
  journal = {CNS drug reviews},
  year    = {2002},
  doi     = {10.1111/j.1527-3458.2002.tb00221.x},
  pmid    = {12177686},
  url     = {https://doi.org/10.1111/j.1527-3458.2002.tb00221.x}
}

@article{fang2012-22015470,
  author  = {Fang, F. and Chen, X. and Huang, T. and Lue, L. F. and Luddy, J. S. and Yan, S. S.},
  title   = {{Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model}},
  journal = {Biochimica et biophysica acta},
  year    = {2012},
  doi     = {10.1016/j.bbadis.2011.10.004},
  pmid    = {22015470},
  url     = {https://doi.org/10.1016/j.bbadis.2011.10.004}
}

@article{chitnis2015-26705381,
  author  = {Chitnis, A.S. and Aparasu, Rajender R. and Chen, Hua and Kunik, Mark E. and Schulz, Paul Ernest and Johnson, Michael L.},
  title   = {{Use of Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Risk of Dementia in Heart Failure}},
  journal = {American Journal of Alzheimer s Disease \& Other Dementias®},
  year    = {2015},
  doi     = {10.1177/1533317515618799},
  pmid    = {26705381},
  url     = {https://doi.org/10.1177/1533317515618799}
}

@article{rahbek2026-42050692,
  author  = {Rahbek, Martin Torp and Kildegaard, Helene and Hallas, Jesper and Ernst, Martin and Lund, Lars Christian},
  title   = {{Acetylcholinesterase inhibitors and the risk of delirium – a Danish nationwide register-based cohort study}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-02060-1},
  pmid    = {42050692},
  url     = {https://doi.org/10.1186/s13195-026-02060-1}
}

@article{tyagi2026-41510854,
  author  = {Tyagi, S. and Murali, N. and Singh, S. K. and Babtiwale, SR. and Padhi, B. K. and Lakshmi, N. R. A. and Gandhi, A. P.},
  title   = {{A Systematic Review to Evaluate the Effect of Neflamapimod on Cognitive Function and Progression of Dementia}},
  journal = {Neurology India},
  year    = {2026},
  doi     = {10.4103/neurol-india.neurol-india-d-25-00227},
  pmid    = {41510854},
  url     = {https://doi.org/10.4103/neurol-india.neurol-india-d-25-00227}
}

@article{basheer2022-35612544,
  author  = {Basheer, A. and Agarwal, A. and Mishra, B. and Gupta, A. and Padma Srivastava, M. V. and Kirubakaran, R. and Vishnu, V.},
  title   = {{Use of Bacopa monnieri in the Treatment of Dementia Due to Alzheimer Disease: Systematic Review of Randomized Controlled Trials}},
  journal = {Interactive journal of medical research},
  year    = {2022},
  doi     = {10.2196/38542},
  pmid    = {35612544},
  url     = {https://doi.org/10.2196/38542}
}

@article{khartabil2025-39998021,
  author  = {Khartabil, N. and Awaness, A.},
  title   = {{Targeting Amyloid Pathology in Early Alzheimer's: The Promise of Donanemab-Azbt}},
  journal = {Pharmacy (Basel, Switzerland)},
  year    = {2025},
  doi     = {10.3390/pharmacy13010023},
  pmid    = {39998021},
  url     = {https://doi.org/10.3390/pharmacy13010023}
}

@article{moussavi2021-34383681,
  author  = {Moussavi, Z. and Koski, L. and Fitzgerald, P. B. and Millikin, C. and Lithgow, B. and Jafari-Jozani, M. and Wang, X.},
  title   = {{Repeated Transcranial Magnetic Stimulation for Improving Cognition in Alzheimer Disease: Protocol for an Interim Analysis of a Randomized Controlled Trial}},
  journal = {JMIR research protocols},
  year    = {2021},
  doi     = {10.2196/31183},
  pmid    = {34383681},
  url     = {https://doi.org/10.2196/31183}
}

@article{wang2019-31852125,
  author  = {Wang, H. and Liu, N. and Wei, Y. and Pei, H. and Liu, M. and Diao, X. and Zhang, H. and Li, H.},
  title   = {{Efficacy and safety of Shenmayizhi decoction as an adjuvant treatment for vascular dementia: Study protocol for a randomized controlled trial}},
  journal = {Medicine},
  year    = {2019},
  doi     = {10.1097/md.0000000000018326},
  pmid    = {31852125},
  url     = {https://doi.org/10.1097/md.0000000000018326}
}

@article{jung2009-19652386,
  author  = {Jung, H. A. and Min, B. S. and Yokozawa, T. and Lee, J. H. and Kim, Y. S. and Choi, J. S.},
  title   = {{Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids}},
  journal = {Biological \& pharmaceutical bulletin},
  year    = {2009},
  doi     = {10.1248/bpb.32.1433},
  pmid    = {19652386},
  url     = {https://doi.org/10.1248/bpb.32.1433}
}

@article{viayna2014-24568372,
  author  = {Viayna, E. and Sola, I. and Bartolini, M. and De Simone, A. and Tapia-Rojas, C. and Serrano, F. G. and Sabaté, R. and Juárez-Jiménez, J. and others},
  title   = {{Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents}},
  journal = {Journal of medicinal chemistry},
  year    = {2014},
  doi     = {10.1021/jm401824w},
  pmid    = {24568372},
  url     = {https://doi.org/10.1021/jm401824w}
}

@article{mishra2008-19966973,
  author  = {Mishra, S. and Palanivelu, K.},
  title   = {{The effect of curcumin (turmeric) on Alzheimer's disease: An overview}},
  journal = {Annals of Indian Academy of Neurology},
  year    = {2008},
  doi     = {10.4103/0972-2327.40220},
  pmid    = {19966973},
  url     = {https://doi.org/10.4103/0972-2327.40220}
}

@article{singhal2025-40359013,
  author  = {Singhal, Tarun and Cicero, Steven and Gale, Seth A. and Horan, Nicolas and Dubey, Shipra and Marshall, Gad A. and Weiner, Howard L.},
  title   = {{Dampening of Microglial Activation With Nasal Foralumab Administration in Moderate Alzheimer’s Disease Dementia}},
  journal = {Clinical Nuclear Medicine},
  year    = {2025},
  doi     = {10.1097/rlu.0000000000005955},
  pmid    = {40359013},
  url     = {https://doi.org/10.1097/rlu.0000000000005955}
}

@article{james2025-41061670,
  author  = {James, Rebecca E. and Bekier, Michael E. and Lee, P. and Schroeder, Frederick A. and Evans, Lauren Jayne and Wagner, Florence F. and Hickman, Dean and Richardson, Tom and others},
  title   = {{A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awaf380},
  pmid    = {41061670},
  url     = {https://doi.org/10.1093/brain/awaf380}
}

@article{kaur2024-39136022,
  author  = {Kaur, S. and Sharma, K. and Sharma, A. and Sandha, K. K. and Ali, S. M. and Ahmed, R. and Ramajayan, P. and Singh, P. P. and others},
  title   = {{Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology}},
  journal = {Frontiers in immunology},
  year    = {2024},
  doi     = {10.3389/fimmu.2024.1418422},
  pmid    = {39136022},
  url     = {https://doi.org/10.3389/fimmu.2024.1418422}
}

@article{mahgoub2016-26946981,
  author  = {Mahgoub, N. and Alexopoulos, G. S.},
  title   = {{Amyloid Hypothesis: Is There a Role for Antiamyloid Treatment in Late-Life Depression?}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2016},
  doi     = {10.1016/j.jagp.2015.12.003},
  pmid    = {26946981},
  url     = {https://doi.org/10.1016/j.jagp.2015.12.003}
}

@article{mandel2008-19040558,
  author  = {Mandel, S. A. and Amit, T. and Weinreb, O. and Reznichenko, L. and Youdim, M. B.},
  title   = {{Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases}},
  journal = {CNS neuroscience \& therapeutics},
  year    = {2008},
  doi     = {10.1111/j.1755-5949.2008.00060.x},
  pmid    = {19040558},
  url     = {https://doi.org/10.1111/j.1755-5949.2008.00060.x}
}

@article{jeppsson2012-23048024,
  author  = {Jeppsson, F. and Eketjäll, S. and Janson, J. and Karlström, S. and Gustavsson, S. and Olsson, L. L. and Radesäter, A. C. and Ploeger, B. and others},
  title   = {{Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.409110},
  pmid    = {23048024},
  url     = {https://doi.org/10.1074/jbc.m112.409110}
}

@article{cheng2017-28356312,
  author  = {Cheng, Y. S. and Chen, Z. T. and Liao, T. Y. and Lin, C. and Shen, H. C. and Wang, Y. H. and Chang, C. W. and Liu, R. S. and others},
  title   = {{An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice}},
  journal = {EMBO molecular medicine},
  year    = {2017},
  doi     = {10.15252/emmm.201606666},
  pmid    = {28356312},
  url     = {https://doi.org/10.15252/emmm.201606666}
}

@article{tandoro2025-39939643,
  author  = {Tandoro, Yohanes and Chiu, Hui‐Fang and Tan, Chei-Ling and Hsieh, Ming‐Hong and Huang, Yi‐Wen and Yu, Jianhua and Wang, Li‐Shu and Chan, Chi‐Ho and others},
  title   = {{Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study}},
  journal = {npj Science of Food},
  year    = {2025},
  doi     = {10.1038/s41538-024-00356-w},
  pmid    = {39939643},
  url     = {https://doi.org/10.1038/s41538-024-00356-w}
}

@article{zuliani2025-41396413,
  author  = {Zuliani, Giovanni and Brombo, Gloria and Romagnoli, Tommaso and Polastri, Michele and Dario, Francesco di Paola and Zuin, Marco},
  title   = {{Effectiveness of acetylcholinesterase inhibitors and memantine in patients affected by severe dementia}},
  journal = {GeroScience},
  year    = {2025},
  doi     = {10.1007/s11357-025-02052-3},
  pmid    = {41396413},
  url     = {https://doi.org/10.1007/s11357-025-02052-3}
}

@article{katsoulaki2025-40573227,
  author  = {Katsoulaki, Eleftheria-Emmanouela and Dimopoulos, Dimitrios and Hadjipavlou‐Litina, Dimitra},
  title   = {{Multitarget Compounds Designed for Alzheimer, Parkinson, and Huntington Neurodegeneration Diseases}},
  journal = {Pharmaceuticals},
  year    = {2025},
  doi     = {10.3390/ph18060831},
  pmid    = {40573227},
  url     = {https://doi.org/10.3390/ph18060831}
}

@article{shami2026-40990233,
  author  = {Shami, R. and El Majzoub, R. and Ismail, A. and Kotaich, J. and Kassem, M. and Safadieh, G. and Fayyad-Kazan, M. and Chahine, B.},
  title   = {{Effects of triptolide herb on the progression of Alzheimer's disease preclinical models: a systematic review}},
  journal = {Neurodegenerative disease management},
  year    = {2026},
  doi     = {10.1080/17582024.2025.2562776},
  pmid    = {40990233},
  url     = {https://doi.org/10.1080/17582024.2025.2562776}
}

@article{ohkura1994-8528351,
  author  = {Ohkura, T. and Isse, K. and Akazawa, K. and Hamamoto, M. and Yaoi, Y. and Hagino, N.},
  title   = {{Evaluation of estrogen treatment in female patients with dementia of the Alzheimer type}},
  journal = {Endocrine journal},
  year    = {1994},
  doi     = {10.1507/endocrj.41.361},
  pmid    = {8528351},
  url     = {https://doi.org/10.1507/endocrj.41.361}
}

@article{luo2023-9f1100a2,
  author  = {Luo, Xiaochan and de Chaves, Jakson Roberto Gaeski and Wang, Andrew and Steffen, David R. and Dhamane, A D and Dai, Feng},
  title   = {{Factors associated with delayed treatment initiation of oral anticoagulants among Medicare patients with atrial fibrillation}},
  journal = {European Heart Journal},
  year    = {2023},
  doi     = {10.1093/eurheartj/ehad655.535},
  url     = {https://doi.org/10.1093/eurheartj/ehad655.535}
}

@article{felbecker2025-40222353,
  author  = {Felbecker, Ansgar and Rouaud, Olivier and Lathuilière, Aurélien and Allali, Gilles and Sollberger, Marc A. and Meyer-Heim, Tatjana and Monsch, Andreas Urs and Lövblad, Karl‐Olof and others},
  title   = {{Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer Disease: Intersocietal Recommendations for Their Appropriate Use in Switzerland}},
  journal = {Neurodegenerative Diseases},
  year    = {2025},
  doi     = {10.1159/000545799},
  pmid    = {40222353},
  url     = {https://doi.org/10.1159/000545799}
}

@article{liu2026-42746606,
  author  = {Liu, Andy and Moghadam, Alexander A. and Alam, Mohammad Samsul and Lutz, Michael William and Navarra, Amber and Luo, Sheng and Wang, Li and Petrella, Jeffrey R. and others},
  title   = {{Clinical Practice Outcomes With Lecanemab for Alzheimer Disease}},
  journal = {Neurology Open Access},
  year    = {2026},
  doi     = {10.1212/wn9.0000000000000121},
  pmid    = {42746606},
  url     = {https://doi.org/10.1212/wn9.0000000000000121}
}

@article{kainuma2020-32957414,
  author  = {Kainuma, M. and Funakoshi, K. and Ouma, S. and Yamashita, K. I. and Ohara, T. and Yoshiiwa, A. and Murata, M. and Tsuboi, Y.},
  title   = {{The efficacy and safety of hachimijiogan for mild Alzheimer disease in an exploratory, open standard treatment controlled, randomized allocation, multicenter trial: A study protocol}},
  journal = {Medicine},
  year    = {2020},
  doi     = {10.1097/md.0000000000022370},
  pmid    = {32957414},
  url     = {https://doi.org/10.1097/md.0000000000022370}
}

@article{piazzi2008-17998161,
  author  = {Piazzi, L. and Cavalli, A. and Colizzi, F. and Belluti, F. and Bartolini, M. and Mancini, F. and Recanatini, M. and Andrisano, V. and others},
  title   = {{Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds}},
  journal = {Bioorganic \& medicinal chemistry letters},
  year    = {2008},
  doi     = {10.1016/j.bmcl.2007.09.100},
  pmid    = {17998161},
  url     = {https://doi.org/10.1016/j.bmcl.2007.09.100}
}

@article{bellversanchis2026-41445192,
  author  = {Bellver-Sanchis, A. and Valle-Garcia, D. and Barbaraci, C. and Romero-Becerra, F. and Singh, R. K. and Jarne-Ferrer, J. and Vasilopoulou, F. and Irisarri, A. and others},
  title   = {{First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer disease}},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year    = {2026},
  doi     = {10.1016/j.ymthe.2025.12.038},
  pmid    = {41445192},
  url     = {https://doi.org/10.1016/j.ymthe.2025.12.038}
}

@article{chen2012-21901364,
  author  = {Chen, S. and Liu, A. R. and An, F. M. and Yao, W. B. and Gao, X. D.},
  title   = {{Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4}},
  journal = {Age (Dordrecht, Netherlands)},
  year    = {2012},
  doi     = {10.1007/s11357-011-9303-8},
  pmid    = {21901364},
  url     = {https://doi.org/10.1007/s11357-011-9303-8}
}

@article{heo2026-41527747,
  author  = {Heo, Rachel J. and Negida, Ahmed and Barrett, Matthew J. and Chrenka, Ella A. B. and Bayram, Ece and Kane, Joseph P. M. and Werner, Ann M. and Rossom, Rebecca C. and others},
  title   = {{Cholinesterase inhibitors for patients with dementia: Patterns of prescribing and disparities in treatment}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1177/13872877251411418},
  pmid    = {41527747},
  url     = {https://doi.org/10.1177/13872877251411418}
}

@article{rustamzadeh2023-38318412,
  author  = {Rustamzadeh, A. and Sadigh, N. and Shabani, R. and Ahadi, R. and Vahabi, Z. and Shabani, A. and Mohebi, N. and Khamseh, F. and others},
  title   = {{Neurochemical Ameliorating of the Hippocampus in Dyslipidemic Alzheimer Patients Following Silymarin; a Double-Blind Placebo-Controlled Randomized Clinical Trial}},
  journal = {Medical journal of the Islamic Republic of Iran},
  year    = {2023},
  doi     = {10.47176/mjiri.37.123},
  pmid    = {38318412},
  url     = {https://doi.org/10.47176/mjiri.37.123}
}

@article{oosthoek2023-37874087,
  author  = {Oosthoek, M. and Lili, A. and Almeida, A. and van Loosbroek, O. and van der Geest, R. and de Greef-van der Sandt, I. and van Bokhoven, P. and Sikkes, S. A. M. and others},
  title   = {{ASURE Clinical Trial Protocol: A Randomized, Placebo-Controlled, Proof-of-Concept Study Aiming to Evaluate Safety and Target Engagement following Administration of TW001 in Early Alzheimer's Disease Patients}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2023},
  doi     = {10.14283/jpad.2023.107},
  pmid    = {37874087},
  url     = {https://doi.org/10.14283/jpad.2023.107}
}

@article{hafez2026-42084750,
  author  = {Hafez, Mohamed Mahmoud and Abbas, Haidy A. and Shoman, Nabil A. and Soubh, Ayman A. and Aly, Omnia and Sallam, Mohamed F. and Seliem, Mahmoud A. and Malaak, Fady A.},
  title   = {{A new era in neuropharmacology: assessing the efficacy and safety of novel anti-amyloid and non-amyloid drug targets for Alzheimer's disease}},
  journal = {Journal of Neurology},
  year    = {2026},
  doi     = {10.1007/s00415-026-13829-7},
  pmid    = {42084750},
  url     = {https://doi.org/10.1007/s00415-026-13829-7}
}

@article{akter2025-40649239,
  author  = {Akter, Sharmin and Tohge, Takayuki and Ananda, Sahithya Hulimane and Kuragano, Masahiro and Tokuraku, Kiyotaka and Uwai, Koji},
  title   = {{Anti-Amyloid Aggregation Effects of Gobaishi (Galla chinensis) and Its Active Constituents}},
  journal = {Molecules},
  year    = {2025},
  doi     = {10.3390/molecules30132720},
  pmid    = {40649239},
  url     = {https://doi.org/10.3390/molecules30132720}
}

@article{xie2025-40709010,
  author  = {Xie, Qingping and Pak, Changsik John and Kwon, Jin Geun and Chao, Sung‐Chuan and Hong, Joon Pio},
  title   = {{Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia}},
  journal = {Archives of Plastic Surgery},
  year    = {2025},
  doi     = {10.1055/a-2627-9243},
  pmid    = {40709010},
  url     = {https://doi.org/10.1055/a-2627-9243}
}

@article{pagan2025-40939527,
  author  = {Pagán, Fernando and Torres-Yaghi, Yasar A. and Hebron, Michaeline L. and Wilmarth, Barbara and Liu, Xiaoguang and Ahn, Jaeil and Moussa, Charbel},
  title   = {{Safety, tolerability and potential biomarkers of vodobatinib in patients with dementia with Lewy bodies}},
  journal = {Parkinsonism \& Related Disorders},
  year    = {2025},
  doi     = {10.1016/j.parkreldis.2025.108020},
  pmid    = {40939527},
  url     = {https://doi.org/10.1016/j.parkreldis.2025.108020}
}

@article{savall2024-38391705,
  author  = {Savall, A. S. P. and de Mello, J. D. and Fidelis, E. M. and Comis-Neto, A. A. and Nepomuceno, M. R. and Pacheco, C. O. and Haas, S. E. and Pinton, S.},
  title   = {{Nanoencapsulated Curcumin: Enhanced Efficacy in Reversing Memory Loss in An Alzheimer Disease Model}},
  journal = {Brain sciences},
  year    = {2024},
  doi     = {10.3390/brainsci14020130},
  pmid    = {38391705},
  url     = {https://doi.org/10.3390/brainsci14020130}
}

@article{sanchezperez2022-35327020,
  author  = {Sánchez-Pérez, A. and Mendialdua-Canales, D. and Hurtado-Pomares, M. and Peral-Gómez, P. and Juárez-Leal, I. and Espinosa-Sempere, C. and Fernández-Pires, P. and Zango-Martín, I. and others},
  title   = {{The ATENción Plena en Enfermedad de Alzheimer (ATENEA-Mindfulness in Alzheimer's Disease) Program for Caregivers: Study Protocol for a Randomized Controlled Trial}},
  journal = {Healthcare (Basel, Switzerland)},
  year    = {2022},
  doi     = {10.3390/healthcare10030542},
  pmid    = {35327020},
  url     = {https://doi.org/10.3390/healthcare10030542}
}

@article{monfared2025-41433980,
  author  = {Monfared, Amir Abbas Tahami and Zhang, Raymond J. and Zhang, Quanwu and Gao, Ran and Haji, Babak},
  title   = {{Lecanemab adoption and geographic variation among patients with diagnosis of mild cognitive impairment or Alzheimer's dementia in Medicare fee‐for‐service beneficiaries}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_106870},
  pmid    = {41433980},
  url     = {https://doi.org/10.1002/alz70860_106870}
}

@article{ravi2025-40421258,
  author  = {Ravi, Renju and Das, Saibal and Hakami, Tahir M. and Prakash, Brahm and Pushparajan, Libby},
  title   = {{Pharmacotherapy for Poststroke Cognitive Impairment and Poststroke Cognitive Impairment With Dementia: A Review}},
  journal = {Stroke Research and Treatment},
  year    = {2025},
  doi     = {10.1155/srat/6893801},
  pmid    = {40421258},
  url     = {https://doi.org/10.1155/srat/6893801}
}

@article{igarashi2026-42108615,
  author  = {Igarashi, A. and Azuma-Kasai, M. and Tani, M. and Utsumi, T. and Shibahara, H. and Inoue, S. and Rothwell, S. and Kamanaka, G. and Sakata, Y. and Hiyoshi, H. and Tomita, K.},
  title   = {{The social value of lecanemab for patients with early Alzheimer's disease in Japan}},
  journal = {Journal of Alzheimer's Disease},
  year    = {2026},
  doi     = {10.1177/13872877261447312},
  pmid    = {42108615},
  url     = {https://doi.org/10.1177/13872877261447312}
}

@article{abosharaf2024-39585487,
  author  = {Abosharaf, H. A. and Elsonbaty, Y. and Tousson, E. and Mohamed, T. M.},
  title   = {{Metformin effectively alleviates the symptoms of Alzheimer in rats by lowering amyloid β deposition and enhancing the insulin signal}},
  journal = {Metabolic brain disease},
  year    = {2024},
  doi     = {10.1007/s11011-024-01422-8},
  pmid    = {39585487},
  url     = {https://doi.org/10.1007/s11011-024-01422-8}
}

@article{peters2011-22228829,
  author  = {Peters, M. E. and Vaidya, V. and Drye, L. T. and Rosenberg, P. B. and Martin, B. K. and Porsteinsson, A. P. and Frangakis, C. E. and Mintzer, J. and others},
  title   = {{Sertraline for the treatment of depression in Alzheimer disease: genetic influences}},
  journal = {Journal of geriatric psychiatry and neurology},
  year    = {2011},
  doi     = {10.1177/0891988711422527},
  pmid    = {22228829},
  url     = {https://doi.org/10.1177/0891988711422527}
}

@article{sambamoorthi2016-27761472,
  author  = {Sambamoorthi, Usha and Deb, Arijita and Zhou, Steve and Garg, Rahul and Fan, Tao and Boss, Anders},
  title   = {{Rapid Acting Insulin Use and Persistence among Elderly Type 2 Diabetes Patients Adding RAI to Oral Antidiabetes Drug Regimens}},
  journal = {Journal of Diabetes Research},
  year    = {2016},
  doi     = {10.1155/2016/5374931},
  pmid    = {27761472},
  url     = {https://doi.org/10.1155/2016/5374931}
}

@article{weiss2026-42373113,
  author  = {Weiss, Sophie M. and Watt, Jennifer A. and Ewa, Vivian and Straus, Sharon Elizabeth},
  title   = {{Lecanemab use for early Alzheimer disease in Canada}},
  journal = {Canadian Medical Association Journal},
  year    = {2026},
  doi     = {10.1503/cmaj.260193},
  pmid    = {42373113},
  url     = {https://doi.org/10.1503/cmaj.260193}
}

@article{zhang2025-40521199,
  author  = {Zhang, Yueqi and Jiang, Lixian and Wu, Rongrong and Gao, Wei and Zhang, Xiaojie and Liu, Lan and Zhang, Yaxuan and others},
  title   = {{An AIM2 inflammasome biomimetic mineralization inhibitor for vascular dementia therapy}},
  journal = {Theranostics},
  year    = {2025},
  doi     = {10.7150/thno.110389},
  pmid    = {40521199},
  url     = {https://doi.org/10.7150/thno.110389}
}

@article{temnik2025-40274975,
  author  = {Temnik, Max and Rudyk, Mariia P. and Балакин, А. А. and Gurin, Sergey and Dovbynchuk, Taisa and Byshovets, Roman and Dziubenko, Natalia and Tolstanova, Ganna M. and others},
  title   = {{Anti-inflammatory effects of 64Zn-aspartate is accompanied by cognitive improvements in rats with Aβ1-40-induced alzheimer disease}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-97830-6},
  pmid    = {40274975},
  url     = {https://doi.org/10.1038/s41598-025-97830-6}
}

@article{hyemin2026-42449395,
  author  = {Hyemin, Jang and Woo, Kim Jae and Won, Hwang Jung and Da Woon, Jeong and Jeongeun, Ka and Da Min, Kang and Hyun, Suh Chong and Yangsean, Choi and others},
  title   = {{Real-world safety and implementation challenges of lecanemab therapy for Alzheimer's disease in South Korea: a single-center experience}},
  journal = {Alzheimer's research \& therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-02141-1},
  pmid    = {42449395},
  url     = {https://doi.org/10.1186/s13195-026-02141-1}
}

@article{spiegel2011-21418632,
  author  = {Spiegel, R. and Berres, M. and Miserez, A. R. and Monsch, A. U. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{For debate: substituting placebo controls in long-term Alzheimer's prevention trials}},
  journal = {Alzheimer's research \& therapy},
  year    = {2011},
  doi     = {10.1186/alzrt68},
  pmid    = {21418632},
  url     = {https://doi.org/10.1186/alzrt68}
}

@article{thakurathi2012-22730476,
  author  = {Thakurathi, Neelam and Henderson, David C.},
  title   = {{Atypical antipsychotics are associated with incident diabetes in older adults without schizophrenia or bipolar disorder}},
  journal = {Evidence-Based Mental Health},
  year    = {2012},
  doi     = {10.1136/ebmental-2012-100740},
  pmid    = {22730476},
  url     = {https://doi.org/10.1136/ebmental-2012-100740}
}

@article{jacova2010-5ee8585a,
  author  = {Jacova, Claudia and Maclure, Malcolm and Hosick, David and Mattson, Ron and Hsiung, Ging‐Yuek Robin and Lee, Philip John and Rabheru, Kiran and Beattie, B. Lynn and others},
  title   = {{P3‐429: Response to cholinesterase inhibitor medication at first renewal in a Canadian provincial drug coverage initiative: the British Columbia Alzheimer's Drug Therapy Initiative (BC ADTI) experience}},
  journal = {Alzheimer s \& Dementia},
  year    = {2010},
  doi     = {10.1016/j.jalz.2010.05.1972},
  url     = {https://doi.org/10.1016/j.jalz.2010.05.1972}
}

@article{stern2025-41435407,
  author  = {Stern, Andrew M. and Francis, Anna G. and Meunier, Angela L. and Anderson, Amirah K. and Hennessey, Elizabeth L. and Miller, Michael B. and Lemere, Cynthia Ann and Selkoe, Dennis J.},
  title   = {{Lecanemab, aducanumab, and donanemab bind the same human Alzheimer disease Aβ aggregates at different epitopes}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_099914},
  pmid    = {41435407},
  url     = {https://doi.org/10.1002/alz70855_099914}
}

@article{donati2025-40217276,
  author  = {Donati, Monia and Boccia, Angelo Sabato and De Ponti, Fabrizio and Poluzzi, Elisabetta and Raschi, Emanuel},
  title   = {{Long-term surveillance of the anti-amyloid monoclonal antibody lecanemab: rights and duties of pharmacovigilance}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01699-6},
  pmid    = {40217276},
  url     = {https://doi.org/10.1186/s13195-025-01699-6}
}

@article{sha2026-42368154,
  author  = {Sha, Jiaojiao and Geng, Zijin and Qi, Shanyu and Du, Liangjia and Hu, Qianqian and Cai, Minqi and Chen, Dezhu and Chen, Yuehua and others},
  title   = {{Characterization of the Anti-Alzheimer Drug Lecanemab by Mass Spectrometry}},
  journal = {ACS Omega},
  year    = {2026},
  doi     = {10.1021/acsomega.6c02666},
  pmid    = {42368154},
  url     = {https://doi.org/10.1021/acsomega.6c02666}
}

@article{jessen2025-40640062,
  author  = {Jessen, Frank and Arbizu, Javier and Boada, Merçé and Balasa, Mircea and Bennys, Karim and Boban, Marina and Bürger, Katharina and Chincarini, A. and others},
  title   = {{Comment by European Alzheimer’s Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer’ s disease}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100259},
  pmid    = {40640062},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100259}
}

@article{bu2025-40337511,
  author  = {Bu, Yifan and Li, Songzhe and Ye, Ting and Wang, Yuqing and Song, Mingrong and Chen, Jing},
  title   = {{Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia}},
  journal = {Frontiers in Pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1552801},
  pmid    = {40337511},
  url     = {https://doi.org/10.3389/fphar.2025.1552801}
}

@article{stroud2026-41689409,
  author  = {Stroud, Jared and Cummings, Jeffrey L. and Chumki, Sanjeda R and Such, Pedro and Wang, David and Palma, Anton M. and Zhang, Z. and Grossberg, George Thomas},
  title   = {{Brexpiprazole for treating agitation in different groups of people with Alzheimer’s dementia: a plain language summary}},
  journal = {Neurodegenerative Disease Management},
  year    = {2026},
  doi     = {10.1080/17582024.2026.2623968},
  pmid    = {41689409},
  url     = {https://doi.org/10.1080/17582024.2026.2623968}
}

@article{hansen2025-41052542,
  author  = {Hansen, Niels and Wiltfang, Jens},
  title   = {{Krankheitsmodifizierende Therapie mit Lecanemab bei früher Alzheimer-Demenz}},
  journal = {Fortschritte der Neurologie · Psychiatrie},
  year    = {2025},
  doi     = {10.1055/a-2681-4558},
  pmid    = {41052542},
  url     = {https://doi.org/10.1055/a-2681-4558}
}

@article{schwartz2025-40584633,
  author  = {Schwartz, Nicholas U. and Dietz, Connor D. and Araújo, Igor Prufer and Villanueva-Meyer, Javier E. and Chiong, Winston and Lane‐Donovan, Courtney and VandeVrede, Lawren A. and Ljubenkov, Peter Alexander and others},
  title   = {{Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease}},
  journal = {Neurology Clinical Practice},
  year    = {2025},
  doi     = {10.1212/cpj.0000000000200508},
  pmid    = {40584633},
  url     = {https://doi.org/10.1212/cpj.0000000000200508}
}

@article{bianchini2025-40231522,
  author  = {Bianchini, Matheus Chimelo and Franscescon, Francini and Soares, Adinei Abadio and Ansolin, Vinicius and Pretto, Kailane Paula and da Cunha, Marcelo Lemos Vieira and Silva, Débora Tavares de Resende e},
  title   = {{Potential Benefits of Quercetin through P2X7 Modulation against Neuroinflammation in Alzheimer's Disease}},
  journal = {Current Neuropharmacology},
  year    = {2025},
  doi     = {10.2174/011570159x355614250130100132},
  pmid    = {40231522},
  url     = {https://doi.org/10.2174/011570159x355614250130100132}
}

@article{ameen2025-2abd646d,
  author  = {Ameen, Taha Basit and Ali, Umair and Salma, Omme and Samee, Muhammad Abdul and Abbas, Syed Muhammad Iraj and Kashif, Syeda Naveera and Arifi, Muhammad Arif and Ali, Mashooque and others},
  title   = {{Amyloid solutions: lecanemab, gantenerumab, and donanemab in the treatment of Alzheimer's disease}},
  journal = {The Egyptian Journal of Neurology Psychiatry and Neurosurgery},
  year    = {2025},
  doi     = {10.1186/s41983-025-00968-3},
  url     = {https://doi.org/10.1186/s41983-025-00968-3}
}

@article{todkar2025-44a6f0db,
  author  = {Todkar, Rohit R. and Shirote, Pramodkumar J. and Mohite, Shrinivas Krishna},
  title   = {{In Silico Screening and DFT Analysis of Nelumbo nucifera Phytochemicals as Potential BACE-1 Inhibitors for Alzheimer’s disease}},
  journal = {Prospects in Pharmaceutical Sciences},
  year    = {2025},
  doi     = {10.56782/pps.379},
  url     = {https://doi.org/10.56782/pps.379}
}

@article{baek2016-28119873,
  author  = {Baek, S. S. and Kim, S. H.},
  title   = {{Treadmill exercise ameliorates symptoms of Alzheimer disease through suppressing microglial activation-induced apoptosis in rats}},
  journal = {Journal of exercise rehabilitation},
  year    = {2016},
  doi     = {10.12965/jer.1632858.429},
  pmid    = {28119873},
  url     = {https://doi.org/10.12965/jer.1632858.429}
}

@article{xing2025-41322351,
  author  = {Xing, Hang and Hu, Wen-Long and Bao, Sheng-yong},
  title   = {{Acupuncture modulates the microbiota-gut-brain axis: a novel therapeutic strategy for amnestic mild cognitive impairment}},
  journal = {Frontiers in Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1710066},
  pmid    = {41322351},
  url     = {https://doi.org/10.3389/fnins.2025.1710066}
}

@article{gao2026-91bcd677,
  author  = {Gao, Lan and Watson, R and Yassi, Nawaf},
  title   = {{Cost-Effectiveness of Donanemab for Early Alzheimer Disease in Australia}},
  journal = {Deakin Research Online (Deakin University)},
  year    = {2026},
  doi     = {10.26187/deakin.32142121},
  url     = {https://doi.org/10.26187/deakin.32142121}
}

@article{zhou2025-41448821,
  author  = {Zhou, Hedi and Shobo, Adeola and Hancock, Mark A. and El Ansari, Fatima and Touj, Sara and Malvankar, Medhinee M. and Wu, Pei You and Masson, Louis-Charles and others},
  title   = {{Development of a novel anti‐amyloid therapeutic: an orally administrable anti‐abeta‐oligomer compound in early preventative intervention}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_101967},
  pmid    = {41448821},
  url     = {https://doi.org/10.1002/alz70859_101967}
}

@article{trushin2025-41450141,
  author  = {Trushin, Sergey A. and Ostroot, Mark A. and Trushina, Eugenia V.},
  title   = {{Partial Mitochondrial Complex I Inhibitors as a Therapy for Alzheimer Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_105252},
  pmid    = {41450141},
  url     = {https://doi.org/10.1002/alz70859_105252}
}

@article{allevi2025-40774851,
  author  = {Allevi, Dario and Luchicchi, Antonio and Orefice, Nicola Salvatore},
  title   = {{Nanocarrier-based drug delivery for mild cognitive impairment: Extracellular vesicles and carbon nanotubes as emerging therapeutic tools}},
  journal = {Biomedicine \& Pharmacotherapy},
  year    = {2025},
  doi     = {10.1016/j.biopha.2025.118381},
  pmid    = {40774851},
  url     = {https://doi.org/10.1016/j.biopha.2025.118381}
}

@article{salehiabargouei2025-40356047,
  author  = {Salehi‐Abargouei, Amin and Muka, Taulant and Collet, Tinh‐Hai and Kepp, Kasper P. and Chatelan, Angéline},
  title   = {{Comment on “Associations of semaglutide with first‐time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real‐world data in the US”}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70035},
  pmid    = {40356047},
  url     = {https://doi.org/10.1002/alz.70035}
}

@article{liu2025-40969222,
  author  = {Liu, Yumei and Zhu, Lin and Pei, Zian and Zhou, Zhifan and Su, Xiaolin and Ren, Huixia and Fan, Shuhan and Lan, Xiaoyong and others},
  title   = {{Integrating repetitive transcranial magnetic stimulation and Mediterranean diet for cognitive and anxiety improvement in early Alzheimer's disease: A case report and literature review}},
  journal = {Journal of Alzheimer s Disease Reports},
  year    = {2025},
  doi     = {10.1177/25424823251377988},
  pmid    = {40969222},
  url     = {https://doi.org/10.1177/25424823251377988}
}

@article{figueiro2011-20739160,
  author  = {Figueiró, M. and Ilha, J. and Linck, V. M. and Herrmann, A. P. and Nardin, P. and Menezes, C. B. and Achaval, M. and Gonçalves, C. A. and others},
  title   = {{The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2011},
  doi     = {10.1016/j.phymed.2010.07.013},
  pmid    = {20739160},
  url     = {https://doi.org/10.1016/j.phymed.2010.07.013}
}

@article{luo2024-38510996,
  author  = {Luo, Xuemei and de Chaves, Jakson Roberto Gaeski and Dhamane, Amol D. and Dai, Feng and Latrémouille-Viau, Dominick and Wang, Aolin},
  title   = {{Delayed treatment initiation of oral anticoagulants among Medicare patients with atrial fibrillation}},
  journal = {American Heart Journal Plus Cardiology Research and Practice},
  year    = {2024},
  doi     = {10.1016/j.ahjo.2024.100369},
  pmid    = {38510996},
  url     = {https://doi.org/10.1016/j.ahjo.2024.100369}
}

@article{sharma2025-d453d052,
  author  = {Sharma, Geetika},
  title   = {{Lecanemab, Donanemab, and Emerging Disease Modifying Therapies for Alzheimer Disease: Clinical Evidence and Primary Care Implications in Canada}},
  journal = {International Journal of Science and Research Archive},
  year    = {2025},
  doi     = {10.5281/zenodo.17615265},
  url     = {https://doi.org/10.5281/zenodo.17615265}
}

@article{sharma2025-1b2f6657,
  author  = {Sharma, Geetika},
  title   = {{Lecanemab, Donanemab, and Emerging Disease Modifying Therapies for Alzheimer Disease: Clinical Evidence and Primary Care Implications in Canada}},
  journal = {International Journal of Science and Research Archive},
  year    = {2025},
  doi     = {10.30574/ijsra.2025.17.1.2929},
  url     = {https://doi.org/10.30574/ijsra.2025.17.1.2929}
}

@article{bhati2026-0a449f11,
  author  = {Bhati, Sampat Singh and Tanwar, Sampat Singh},
  title   = {{Therapeutic monoclonal antibodies targeting amyloid beta in Alzheimer disease current evidence clinical outcomes limitations and future directions}},
  journal = {Discover Neuroscience},
  year    = {2026},
  doi     = {10.1186/s13064-026-00295-0},
  url     = {https://doi.org/10.1186/s13064-026-00295-0}
}

@article{bombonalban2025-ab04d0ab,
  author  = {Bombón-Albán, Paulina Elizabeth and Salazar, Johanna Vanessa Suárez and León, Lennyn Albán},
  title   = {{Lecanemab en la enfermedad de Alzheimer}},
  journal = {Acta neurológica colombiana},
  year    = {2025},
  doi     = {10.22379/anc.v41i2.1938},
  url     = {https://doi.org/10.22379/anc.v41i2.1938}
}

@article{kordi2026-42634764,
  author  = {Kordi, Mohammad Reza and Kooshan, Amir Reza and Jafari-Hokmabadi, Seyed Pouya and Gaeini, Abbas Ali and Zobeydi, Amir Mohammad},
  title   = {{Combating cognitive decline in a rat model of Alzheimer’s disease: The role of high-intensity interval training and cannabidiol administration in modulating microRNA-124, BACE1, and nestin}},
  journal = {Current Journal of Neurology},
  year    = {2026},
  doi     = {10.18502/cjn.v24i3.21601},
  pmid    = {42634764},
  url     = {https://doi.org/10.18502/cjn.v24i3.21601}
}

@article{knupflemacher2025-3c483de3,
  author  = {Knupflemacher, Daniel Sánchez and García, Xavier Antonio Sánchez and Salgado, Celina Nicole Angulo and Loyola, Paula Robert and Arce, Joel Santiago and Bautista, Ángel Gabriel Pérez},
  title   = {{Terapias emergentes para la enfermedad de Alzheimer: revisión sistemática de anticuerpos anti-amiloide y mecanismos alternativos}},
  journal = {Revista Científica de Salud y Desarrollo Humano},
  year    = {2025},
  doi     = {10.61368/r.s.d.h.v6i2.661},
  url     = {https://doi.org/10.61368/r.s.d.h.v6i2.661}
}

@article{odonnell2025-42667001,
  author  = {O'Donnell, Alison J and Handler, Steven M and Faieta, Julie and Jump, Robin},
  title   = {{Can Telehealth Improve Access to Amyloid-Targeting Therapies for Veterans Living With Alzheimer Disease?}},
  journal = {Federal Practitioner},
  year    = {2025},
  doi     = {10.12788/fp.0656},
  pmid    = {42667001},
  url     = {https://doi.org/10.12788/fp.0656}
}

@article{sarwade2026-9ce011bf,
  author  = {Sarwade1, Prakash and Gaisamudre*2, Kavita and Sonwani3, Kalpana and Jasra4, Khushboo and Rawat5, Khushi and Saha6, Purabi and Kumar7, Roshan},
  title   = {{Aldehyde-Mediated Neurotoxicity and Lutein Intervention: A Novel Therapeutic Strategy for Alzheimer's Disease}},
  journal = {Zenodo (CERN European Organization for Nuclear Research)},
  year    = {2026},
  doi     = {10.5281/zenodo.18298036},
  url     = {https://doi.org/10.5281/zenodo.18298036}
}

@article{gibizov2025-51978b36,
  author  = {Gibizov, Yuriy A. and Вагапова, Л. Ш. and Aguzarova, Alina O. and Nazarova, Julia V. and Zotkina, Yana A. and Atamanyuk, Ekaterina A. and Rodikova, Mariia M. and Timergaleev, Rafael N. and others},
  title   = {{Physical Activity and the Myokine Irisin in Non-pharmacological Treatment of Alzheimer Disease}},
  journal = {Russian Journal of Physiotherapy Balneology and Rehabilitation},
  year    = {2025},
  doi     = {10.17816/rjpbr677844},
  url     = {https://doi.org/10.17816/rjpbr677844}
}

@article{rotela2026-cf778e0b,
  author  = {Rotela, Lorena Guadalupe Delvalle and Olmedo, Katherinne Ailen Sanchez},
  title   = {{Eficacia del lecanemab en el tratamiento de la Enfermedad de Alzheimer: revisión de la literatura (2015-2025)}},
  journal = {Zenodo (CERN European Organization for Nuclear Research)},
  year    = {2026},
  doi     = {10.5281/zenodo.22756412},
  url     = {https://doi.org/10.5281/zenodo.22756412}
}

@article{crouzet2025-ff920d55,
  author  = {Crouzet, Christian and Liu, Jihua and Choi, Bernard and Cribbs, David H},
  title   = {{A Novel Mouse Model for Investigating ARIAs in Response to Anti-Abeta Immunotherapy}},
  journal = {Cerebral Circulation - Cognition and Behavior},
  year    = {2025},
  doi     = {10.1016/j.cccb.2025.100475},
  url     = {https://doi.org/10.1016/j.cccb.2025.100475}
}

@article{duran2025-d42e1b7d,
  author  = {Durán, Stephanie Hernández and Ceja, Militza Jakeline Gómez},
  title   = {{Lecanemab como tratamiento en el deterioro cognitivo de pacientes con Alzheimer}},
  journal = {Acta Médica Grupo Ángeles},
  year    = {2025},
  doi     = {10.35366/119479},
  url     = {https://doi.org/10.35366/119479}
}

@article{sanz2025-d2104574,
  author  = {Sanz, Mercedes},
  title   = {{Lecanemab autorizado para tratamiento del Alzhéimer en pacientes que tienen una o ninguna copia de ApoE4: una reacción adversa grave limita su uso}},
  journal = {Panorama actual del medicamento},
  year    = {2025},
  doi     = {10.63105/pam8},
  url     = {https://doi.org/10.63105/pam8}
}

@article{bombonalban2026-7db0e4e9,
  author  = {Bombón-Albán, Paulina Elizabeth},
  title   = {{Terapia anti β-amiloide y enfermedad cerebrovascular: nuevos retos para la neurología vascular}},
  journal = {Acta neurológica colombiana},
  year    = {2026},
  doi     = {10.22379/anc.2188},
  url     = {https://doi.org/10.22379/anc.2188}
}

@article{ikemoto2025-e8a83631,
  author  = {Ikemoto, Keiko},
  title   = {{“D-Neuron Protection / Activation (DPA) Therapy”: New Strategy for Treatment of Neuropsychiatric Illnesses}},
  journal = {Advances in Bioengineering and Biomedical Science Research},
  year    = {2025},
  doi     = {10.33140/abbsr.08.01.01},
  url     = {https://doi.org/10.33140/abbsr.08.01.01}
}

@article{kanika2026-329f85f8,
  author  = {Kanika, Pasrija and Patel, Alka and Tripathy, Bichitrananda},
  title   = {{Curcuma longa-Derived Curcumin Nanoparticles in Experimental Models of Alzheimer’s Disease: A Formulation-Based Approach}},
  journal = {Probecell Science},
  year    = {2026},
  doi     = {10.65807/prob.sci.2025.2.2.4},
  url     = {https://doi.org/10.65807/prob.sci.2025.2.2.4}
}

@article{carter2020-26f00cc1,
  author  = {Carter, Elizabeth Jeanne and Tan, Erwin J.},
  title   = {{Concomitant Cholinesterase Inhibitor and Anticholinergic Drug Use Among Older Adults With Dementia}},
  journal = {Innovation in Aging},
  year    = {2020},
  doi     = {10.1093/geroni/igaa057.842},
  url     = {https://doi.org/10.1093/geroni/igaa057.842}
}

@article{titare2025-4e2f63cd,
  author  = {Titare, Vaishnavi Pravin and Salve, Mrs. Sneha K. and Kitukale, M. D.},
  title   = {{Novel Monoclonal Antibodies for the Treatment of Alzheimers Disease using KISUNLA Drug}},
  journal = {International Journal of Advanced Research in Science Communication and Technology},
  year    = {2025},
  doi     = {10.48175/ijarsct-23077},
  url     = {https://doi.org/10.48175/ijarsct-23077}
}

@article{sato2011-21778673,
  author  = {Sato, Y. and Honda, Y. and Umeno, K. and Hayashida, N. and Iwamoto, J. and Takeda, T. and Matsumoto, H.},
  title   = {{The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a randomized controlled trial}},
  journal = {The Kurume medical journal},
  year    = {2011},
  doi     = {10.2739/kurumemedj.57.117},
  pmid    = {21778673},
  url     = {https://doi.org/10.2739/kurumemedj.57.117}
}

@article{taylor2026-9c23dcf2,
  author  = {Taylor, J. and Alam, J. J. and Gomperts, S. N. and Honig, L. S. and Prins, N. D. and Koubiyr, I. and Chu, H. and Gardner, A. and others},
  title   = {{A Phase 2b randomized clinical trial of the oral p38α inhibitor neflamapimod in dementia with Lewy bodies (DLB)}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10623740/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10623740/v1}
}

@article{day2022-35197360,
  author  = {Day, G. S. and Scarmeas, N. and Dubinsky, R. and Coerver, K. and Mostacero, A. and West, B. and Wessels, SR. and Armstrong, M. J.},
  title   = {{Aducanumab Use in Symptomatic Alzheimer Disease Evidence in Focus [RETIRED]: A Report of the AAN Guidelines Subcommittee}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000200176},
  pmid    = {35197360},
  url     = {https://doi.org/10.1212/wnl.0000000000200176}
}

@article{bond2012-22541366,
  author  = {Bond, M. and Rogers, G. and Peters, J. and Anderson, R. and Hoyle, M. and Miners, A. and Moxham, T. and Davis, S. and others},
  title   = {{The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model}},
  journal = {Health technology assessment (Winchester, England)},
  year    = {2012},
  doi     = {10.3310/hta16210},
  pmid    = {22541366},
  url     = {https://doi.org/10.3310/hta16210}
}

@article{wang2026-de659fd9,
  author  = {Wang, C. and Woods, C. and Nguyen, T. and Liu, J. and Lin, A.-L. and Cheng, J.},
  title   = {{Multimodal Transformer Modeling of Rapamycin Treatment in Alzheimer's Disease via Random Forest Feature Filtering}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.22.26361114},
  url     = {https://doi.org/10.64898/2026.08.22.26361114}
}

@article{kuik2026-fb8d9249,
  author  = {Kuik, E. J. and Baena-Tan, C. and Moriguchi, S. and Braga, J. and Miler, L. and Rusjan, P. and Bagby, M. and Husain and others},
  title   = {{Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.08.26362462},
  url     = {https://doi.org/10.64898/2026.09.08.26362462}
}

@article{rafieirezvani2026-50b7bf22,
  author  = {Rafiei Rezvani, F. and Azimi, D. and Nekouei, A. H. and Kim, H. and Sauer, C. C. and Wharton, W. and Qiu, D. and Goldstein and others},
  title   = {{Feasibility, Safety, and Preliminary Efficacy of Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease: A 12-Month Pilot Randomized Controlled Trial}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.11.26362767},
  url     = {https://doi.org/10.64898/2026.09.11.26362767}
}

@article{tiwari2026-334d2e2d,
  author  = {Tiwari, A. and Chen, R. and Tan, Y. and Yan, Y. and Wen, Z. and Wei, W.-Q. and Zhong, X. and Li and others},
  title   = {{Antihypertensive Medication Class and Incident Alzheimers Disease and Related Dementias: External Replication Across Two Independent Healthcare Data Sources-the Vanderbilt EHR Synthetic Derivative and US Medicare Claims}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.11.26362859},
  url     = {https://doi.org/10.64898/2026.09.11.26362859}
}

@article{lopezlarraz2026-5e962d7a,
  author  = {Lopez-Larraz, E. and Oriol, D. and Fierro, G. and Jubera-Garcia, E. and Klinzing, J. G. and Sierra-Torralba, M. and Horna-Prat, E. and Escolano and others},
  title   = {{One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer's Disease}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.14.26360893},
  url     = {https://doi.org/10.64898/2026.09.14.26360893}
}

@article{ma2026-a6a56bb0,
  author  = {Ma, P. and Zhou, J. and Cheng, Y. and McGeary, J. E. and Taveira, T. H. and Ahmed, A. and Wu, W.-C. and Zamrini and others},
  title   = {{Varenicline as a Repurposable Drug Candidate for ADRD Prevention}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.17.26363232},
  url     = {https://doi.org/10.64898/2026.09.17.26363232}
}