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@article{kunkle2019-30820047,
  author  = {Kunkle, B. W. and Grenier-Boley, B. and Sims, R. and Bis, J. C. and Damotte, V. and Naj, A. C. and Boland, A. and Vronskaya, M. and others},
  title   = {{Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing}},
  journal = {Nature genetics},
  year    = {2019},
  doi     = {10.1038/s41588-019-0358-2},
  pmid    = {30820047},
  url     = {https://doi.org/10.1038/s41588-019-0358-2}
}

@article{jansen2015-25988462,
  author  = {Jansen, W. J. and Ossenkoppele, R. and Knol, D. L. and Tijms, B. M. and Scheltens, P. and Verhey, F. R. and Visser, P. J. and {Amyloid Biomarker Study Group} and others},
  title   = {{Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis}},
  journal = {JAMA},
  year    = {2015},
  doi     = {10.1001/jama.2015.4668},
  pmid    = {25988462},
  url     = {https://doi.org/10.1001/jama.2015.4668}
}

@article{belloy2023-37930705,
  author  = {Belloy, M. E. and Andrews, S. J. and Le Guen, Y. and Cuccaro, M. and Farrer, L. A. and Napolioni, V. and Greicius, M. D.},
  title   = {{APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry}},
  journal = {JAMA Neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.3599},
  pmid    = {37930705},
  url     = {https://doi.org/10.1001/jamaneurol.2023.3599}
}

@article{naj2011-21460841,
  author  = {Naj, A. C. and Jun, G. and Beecham, G. W. and Wang, L. S. and Vardarajan, B. N. and Buros, J. and Gallins, P. J. and Buxbaum, J. D. and others},
  title   = {{Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2011},
  doi     = {10.1038/ng.801},
  pmid    = {21460841},
  url     = {https://doi.org/10.1038/ng.801}
}

@article{wightman2021-34493870,
  author  = {Wightman, D. P. and Jansen, I. E. and Savage, J. E. and Shadrin, A. A. and Bahrami, S. and Holland, D. and Rongve, A. and Børte, S. and others},
  title   = {{A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2021},
  doi     = {10.1038/s41588-021-00921-z},
  pmid    = {34493870},
  url     = {https://doi.org/10.1038/s41588-021-00921-z}
}

@article{bouzid2023-37322115,
  author  = {Bouzid, H. and Belk, J. A. and Jan, M. and Qi, Y. and Sarnowski, C. and Wirth, S. and Ma, L. and Chrostek, M. R. and others},
  title   = {{Clonal hematopoiesis is associated with protection from Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2023},
  doi     = {10.1038/s41591-023-02397-2},
  pmid    = {37322115},
  url     = {https://doi.org/10.1038/s41591-023-02397-2}
}

@article{solomon2018-29356827,
  author  = {Solomon, A. and Turunen, H. and Ngandu, T. and Peltonen, M. and Levälahti, E. and Helisalmi, S. and Antikainen, R. and Bäckman, L. and others},
  title   = {{Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2017.4365},
  pmid    = {29356827},
  url     = {https://doi.org/10.1001/jamaneurol.2017.4365}
}

@article{seshadri2010-20460622,
  author  = {Seshadri, S. and Fitzpatrick, A. L. and Ikram, M. A. and DeStefano, A. L. and Gudnason, V. and Boada, M. and Bis, J. C. and Smith, A. V. and others},
  title   = {{Genome-wide analysis of genetic loci associated with Alzheimer disease}},
  journal = {JAMA},
  year    = {2010},
  doi     = {10.1001/jama.2010.574},
  pmid    = {20460622},
  url     = {https://doi.org/10.1001/jama.2010.574}
}

@article{reitz2013-23571587,
  author  = {Reitz, C. and Jun, G. and Naj, A. and Rajbhandary, R. and Vardarajan, B. N. and Wang, L. S. and Valladares, O. and Lin, C. F. and others},
  title   = {{Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans}},
  journal = {JAMA},
  year    = {2013},
  doi     = {10.1001/jama.2013.2973},
  pmid    = {23571587},
  url     = {https://doi.org/10.1001/jama.2013.2973}
}

@article{kunkle2021-33074286,
  author  = {Kunkle, B. W. and Schmidt, M. and Klein, H. U. and Naj, A. C. and Hamilton-Nelson, K. L. and Larson, E. B. and Evans, D. A. and De Jager, P. L. and others},
  title   = {{Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis}},
  journal = {JAMA neurology},
  year    = {2021},
  doi     = {10.1001/jamaneurol.2020.3536},
  pmid    = {33074286},
  url     = {https://doi.org/10.1001/jamaneurol.2020.3536}
}

@article{alves2023-36973044,
  author  = {Alves, F. and Kalinowski, P. and Ayton, S.},
  title   = {{Accelerated Brain Volume Loss Caused by Anti-β-Amyloid Drugs: A Systematic Review and Meta-analysis}},
  journal = {Neurology},
  year    = {2023},
  doi     = {10.1212/wnl.0000000000207156},
  pmid    = {36973044},
  url     = {https://doi.org/10.1212/wnl.0000000000207156}
}

@article{rajabli2025-40676597,
  author  = {Rajabli, F. and Benchek, P. and Tosto, G. and Kushch, N. and Sha, J. and Bazemore, K. and Zhu, C. and Lee, W. P. and others},
  title   = {{Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease}},
  journal = {Genome biology},
  year    = {2025},
  doi     = {10.1186/s13059-025-03564-z},
  pmid    = {40676597},
  url     = {https://doi.org/10.1186/s13059-025-03564-z}
}

@article{bergeron2018-30255971,
  author  = {Bergeron, D. and Gorno-Tempini, M. L. and Rabinovici, G. D. and Santos-Santos, M. A. and Seeley, W. and Miller, B. L. and Pijnenburg, Y. and Keulen, M. A. and others},
  title   = {{Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia}},
  journal = {Annals of neurology},
  year    = {2018},
  doi     = {10.1002/ana.25333},
  pmid    = {30255971},
  url     = {https://doi.org/10.1002/ana.25333}
}

@article{xu2025-40067298,
  author  = {Xu, X. and Kwon, J. and Yan, R. and Apio, C. and Song, S. and Heo, G. and Yang, Q. and Timsina, J. and others},
  title   = {{Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries}},
  journal = {JAMA network open},
  year    = {2025},
  doi     = {10.1001/jamanetworkopen.2025.0562},
  pmid    = {40067298},
  url     = {https://doi.org/10.1001/jamanetworkopen.2025.0562}
}

@article{altmann2014-24623176,
  author  = {Altmann, A. and Tian, L. and Henderson, V. W. and Greicius, M. D. and {Alzheimer's Disease Neuroimaging Initiative Investigators}},
  title   = {{Sex modifies the APOE-related risk of developing Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2014},
  doi     = {10.1002/ana.24135},
  pmid    = {24623176},
  url     = {https://doi.org/10.1002/ana.24135}
}

@article{neu2017-28846757,
  author  = {Neu, S. C. and Pa, J. and Kukull, W. and Beekly, D. and Kuzma, A. and Gangadharan, P. and Wang, L. S. and Romero, K. and others},
  title   = {{Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.2188},
  pmid    = {28846757},
  url     = {https://doi.org/10.1001/jamaneurol.2017.2188}
}

@article{leguen2023-36809323,
  author  = {Le Guen, Y. and Raulin, A. C. and Logue, M. W. and Sherva, R. and Belloy, M. E. and Eger, S. J. and Chen, A. and Kennedy, G. and Kuchenbecker, L. and O'Leary, J. P. and Zhang, R. and Merritt, V. C. and others},
  title   = {{Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease}},
  journal = {JAMA},
  year    = {2023},
  doi     = {10.1001/jama.2023.0268},
  pmid    = {36809323},
  url     = {https://doi.org/10.1001/jama.2023.0268}
}

@article{quiroz2024-38899694,
  author  = {Quiroz, Y. T. and Aguillon, D. and Aguirre-Acevedo, D. C. and Vasquez, D. and Zuluaga, Y. and Baena, A. Y. and Madrigal, L. and Hincapié, L. and Sanchez, J. S. and Langella, S. and Posada-Duque, R. and Littau, J. L. and others},
  title   = {{APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease}},
  journal = {New England Journal of Medicine},
  year    = {2024},
  doi     = {10.1056/NEJMoa2308583},
  pmid    = {38899694},
  url     = {https://doi.org/10.1056/NEJMoa2308583}
}

@article{bhattarai2024-38598053,
  author  = {Bhattarai, P. and Gunasekaran, T. I. and Belloy, M. E. and Reyes-Dumeyer, D. and Jülich, D. and Tayran, H. and Yilmaz, E. and Flaherty, D. and Turgutalp, B. and Sukumar, G. and Alba, C. and McGrath, E. M. and others},
  title   = {{Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease}},
  journal = {Acta Neuropathologica},
  year    = {2024},
  doi     = {10.1007/s00401-024-02721-1},
  pmid    = {38598053},
  url     = {https://doi.org/10.1007/s00401-024-02721-1}
}

@article{chapuis2013-23399914,
  author  = {Chapuis, J. and Hansmannel, F. and Gistelinck, M. and Mounier, A. and Van Cauwenberghe, C. and Kolen, K. V. and Geller, F. and Sottejeau, Y. and others},
  title   = {{Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology}},
  journal = {Molecular psychiatry},
  year    = {2013},
  doi     = {10.1038/mp.2013.1},
  pmid    = {23399914},
  url     = {https://doi.org/10.1038/mp.2013.1}
}

@article{naj2014-25199842,
  author  = {Naj, A. C. and Jun, G. and Reitz, C. and Kunkle, B. W. and Perry, W. and Park, Y. S. and Beecham, G. W. and Rajbhandary, R. A. and others},
  title   = {{Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1491},
  pmid    = {25199842},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1491}
}

@article{nelson2014-24770881,
  author  = {Nelson, P. T. and Estus, S. and Abner, E. L. and Parikh, I. and Malik, M. and Neltner, J. H. and Ighodaro, E. and Wang, W. X. and others},
  title   = {{ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology}},
  journal = {Acta neuropathologica},
  year    = {2014},
  doi     = {10.1007/s00401-014-1282-2},
  pmid    = {24770881},
  url     = {https://doi.org/10.1007/s00401-014-1282-2}
}

@article{huang2024-38501315,
  author  = {Huang, S. Y. and Zhang, Y. R. and Guo, Y. and Du, J. and Ren, P. and Wu, B. S. and Feng, J. F. and {Alzheimer's Disease Neuroimaging Initiative} and Cheng, W. and Yu, J. T.},
  title   = {{Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease}},
  journal = {Alzheimer's \& Dementia},
  year    = {2024},
  doi     = {10.1002/alz.13789},
  pmid    = {38501315},
  url     = {https://doi.org/10.1002/alz.13789}
}

@article{raghavan2020-32568366,
  author  = {Raghavan, N. S. and Dumitrescu, L. and Mormino, E. and Mahoney, E. R. and Lee, A. J. and Gao, Y. and Bilgel, M. and Goldstein, D. and others},
  title   = {{Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.1760},
  pmid    = {32568366},
  url     = {https://doi.org/10.1001/jamaneurol.2020.1760}
}

@article{roostaei2017-27021820,
  author  = {Roostaei, T. and Nazeri, A. and Felsky, D. and De Jager, P. L. and Schneider, J. A. and Pollock, B. G. and Bennett, D. A. and Voineskos, A. N. and others},
  title   = {{Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease}},
  journal = {Molecular psychiatry},
  year    = {2017},
  doi     = {10.1038/mp.2016.35},
  pmid    = {27021820},
  url     = {https://doi.org/10.1038/mp.2016.35}
}

@article{broce2018-29315334,
  author  = {Broce, I. and Karch, C. M. and Wen, N. and Fan, C. C. and Wang, Y. and Tan, C. H. and Kouri, N. and Ross, O. A. and others},
  title   = {{Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies}},
  journal = {PLoS medicine},
  year    = {2018},
  doi     = {10.1371/journal.pmed.1002487},
  pmid    = {29315334},
  url     = {https://doi.org/10.1371/journal.pmed.1002487}
}

@article{tang1998-9508150,
  author  = {Tang, M. X. and Stern, Y. and Marder, K. and Bell, K. and Gurland, B. and Lantigua, R. and Andrews, H. and Feng, L. and others},
  title   = {{The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics}},
  journal = {JAMA},
  year    = {1998},
  doi     = {10.1001/jama.279.10.751},
  pmid    = {9508150},
  url     = {https://doi.org/10.1001/jama.279.10.751}
}

@article{dube2019-31591557,
  author  = {Dube, U. and Del-Aguila, J. L. and Li, Z. and Budde, J. P. and Jiang, S. and Hsu, S. and Ibanez, L. and Fernandez, M. V. and others},
  title   = {{An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0501-5},
  pmid    = {31591557},
  url     = {https://doi.org/10.1038/s41593-019-0501-5}
}

@article{mirza2019-31575706,
  author  = {Mirza, S. S. and Saeed, U. and Knight, J. and Ramirez, J. and Stuss, D. T. and Keith, J. and Nestor, S. M. and Yu, D. and others},
  title   = {{APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia}},
  journal = {Neurology},
  year    = {2019},
  doi     = {10.1212/wnl.0000000000008377},
  pmid    = {31575706},
  url     = {https://doi.org/10.1212/wnl.0000000000008377}
}

@article{caselli2009-19605830,
  author  = {Caselli, R. J. and Dueck, A. C. and Osborne, D. and Sabbagh, M. N. and Connor, D. J. and Ahern, G. L. and Baxter, L. C. and Rapcsak, S. Z. and others},
  title   = {{Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect}},
  journal = {The New England journal of medicine},
  year    = {2009},
  doi     = {10.1056/nejmoa0809437},
  pmid    = {19605830},
  url     = {https://doi.org/10.1056/nejmoa0809437}
}

@article{tsuang2013-23407718,
  author  = {Tsuang, D. and Leverenz, J. B. and Lopez, O. L. and Hamilton, R. L. and Bennett, D. A. and Schneider, J. A. and Buchman, A. S. and Larson, E. B. and others},
  title   = {{APOE ε4 increases risk for dementia in pure synucleinopathies}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.600},
  pmid    = {23407718},
  url     = {https://doi.org/10.1001/jamaneurol.2013.600}
}

@article{slooter1998-9678314,
  author  = {Slooter, A. J. and Cruts, M. and Kalmijn, S. and Hofman, A. and Breteler, M. M. and Van Broeckhoven, C. and van Duijn, C. M.},
  title   = {{Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study}},
  journal = {Archives of neurology},
  year    = {1998},
  doi     = {10.1001/archneur.55.7.964},
  pmid    = {9678314},
  url     = {https://doi.org/10.1001/archneur.55.7.964}
}

@article{miyashita2013-23565137,
  author  = {Miyashita, A. and Koike, A. and Jun, G. and Wang, L. S. and Takahashi, S. and Matsubara, E. and Kawarabayashi, T. and Shoji, M. and others},
  title   = {{SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0058618},
  pmid    = {23565137},
  url     = {https://doi.org/10.1371/journal.pone.0058618}
}

@article{chauhan2015-25670335,
  author  = {Chauhan, G. and Adams, H. H. H. and Bis, J. C. and Weinstein, G. and Yu, L. and Töglhofer, A. M. and Smith, A. V. and van der Lee, S. J. and others},
  title   = {{Association of Alzheimer's disease GWAS loci with MRI markers of brain aging}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2014.12.028},
  pmid    = {25670335},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.12.028}
}

@article{rafii2018-29582053,
  author  = {Rafii, M. S. and Tuszynski, M. H. and Thomas, R. G. and Barba, D. and Brewer, J. B. and Rissman, R. A. and Siffert, J. and Aisen, P. S. and others},
  title   = {{Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2018.0233},
  pmid    = {29582053},
  url     = {https://doi.org/10.1001/jamaneurol.2018.0233}
}

@article{fortea2024-38710950,
  author  = {Fortea, J. and Pegueroles, J. and Alcolea, D. and Belbin, O. and Dols-Icardo, O. and Vaqué-Alcázar, L. and Videla, L. and Gispert, J. D. and others},
  title   = {{APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2024},
  doi     = {10.1038/s41591-024-02931-w},
  pmid    = {38710950},
  url     = {https://doi.org/10.1038/s41591-024-02931-w}
}

@article{yu2015-25365775,
  author  = {Yu, L. and Chibnik, L. B. and Srivastava, G. P. and Pochet, N. and Yang, J. and Xu, J. and Kozubek, J. and Obholzer, N. and others},
  title   = {{Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.3049},
  pmid    = {25365775},
  url     = {https://doi.org/10.1001/jamaneurol.2014.3049}
}

@article{bettens2012-22248099,
  author  = {Bettens, K. and Brouwers, N. and Engelborghs, S. and Lambert, J. C. and Rogaeva, E. and Vandenberghe, R. and Le Bastard, N. and Pasquier, F. and others},
  title   = {{Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk}},
  journal = {Molecular neurodegeneration},
  year    = {2012},
  doi     = {10.1186/1750-1326-7-3},
  pmid    = {22248099},
  url     = {https://doi.org/10.1186/1750-1326-7-3}
}

@article{holstege2022-36411364,
  author  = {Holstege, H. and Hulsman, M. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Grozeva, D. and van Rooij, J. G. J. and Sims, R. and others},
  title   = {{Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2022},
  doi     = {10.1038/s41588-022-01208-7},
  pmid    = {36411364},
  url     = {https://doi.org/10.1038/s41588-022-01208-7}
}

@article{chouraki2015-25217292,
  author  = {Chouraki, V. and Beiser, A. and Younkin, L. and Preis, SR. and Weinstein, G. and Hansson, O. and Skoog, I. and Lambert, J. C. and others},
  title   = {{Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.07.001},
  pmid    = {25217292},
  url     = {https://doi.org/10.1016/j.jalz.2014.07.001}
}

@article{dumanski2016-27231129,
  author  = {Dumanski, J. P. and Lambert, J. C. and Rasi, C. and Giedraitis, V. and Davies, H. and Grenier-Boley, B. and Lindgren, C. M. and Campion, D. and others},
  title   = {{Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease}},
  journal = {American journal of human genetics},
  year    = {2016},
  doi     = {10.1016/j.ajhg.2016.05.014},
  pmid    = {27231129},
  url     = {https://doi.org/10.1016/j.ajhg.2016.05.014}
}

@article{antolini2021-34531298,
  author  = {Antolini, L. and DiFrancesco, J. C. and Zedde, M. and Basso, G. and Arighi, A. and Shima, A. and Cagnin, A. and Caulo, M. and others},
  title   = {{Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000012778},
  pmid    = {34531298},
  url     = {https://doi.org/10.1212/wnl.0000000000012778}
}

@article{hanson2013-23779114,
  author  = {Hanson, A. J. and Bayer-Carter, J. L. and Green, P. S. and Montine, T. J. and Wilkinson, C. W. and Baker, L. D. and Watson, G. S. and Bonner, L. M. and others},
  title   = {{Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.396},
  pmid    = {23779114},
  url     = {https://doi.org/10.1001/jamaneurol.2013.396}
}

@article{leguen2022-35639372,
  author  = {Le Guen, Y. and Belloy, M. E. and Grenier-Boley, B. and de Rojas, I. and Castillo-Morales, A. and Jansen, I. and Nicolas, A. and Bellenguez, C. and others},
  title   = {{Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.1166},
  pmid    = {35639372},
  url     = {https://doi.org/10.1001/jamaneurol.2022.1166}
}

@article{delgadoperaza2023-37730689,
  author  = {Delgado-Peraza, F. and Nogueras-Ortiz, C. and Simonsen, A. H. and Knight, D. D. and Yao, P. J. and Goetzl, E. J. and Jensen, C. S. and Høgh, P. and others},
  title   = {{Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2023},
  doi     = {10.1186/s13195-023-01303-9},
  pmid    = {37730689},
  url     = {https://doi.org/10.1186/s13195-023-01303-9}
}

@article{kapogiannis2015-25342129,
  author  = {Kapogiannis, D. and Boxer, A. and Schwartz, J. B. and Abner, E. L. and Biragyn, A. and Masharani, U. and Frassetto, L. and Petersen, R. C. and others},
  title   = {{Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2015},
  doi     = {10.1096/fj.14-262048},
  pmid    = {25342129},
  url     = {https://doi.org/10.1096/fj.14-262048}
}

@article{shirzadi2023-37843849,
  author  = {Shirzadi, Z. and Schultz, S. A. and Yau, W. W. and Joseph-Mathurin, N. and Fitzpatrick, C. D. and Levin, R. and Kantarci, K. and Preboske, G. M. and others},
  title   = {{Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.3618},
  pmid    = {37843849},
  url     = {https://doi.org/10.1001/jamaneurol.2023.3618}
}

@article{morenograu2019-31473137,
  author  = {Moreno-Grau, S. and de Rojas, I. and Hernández, I. and Quintela, I. and Montrreal, L. and Alegret, M. and Hernández-Olasagarre, B. and Madrid, L. and others},
  title   = {{Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2019},
  doi     = {10.1016/j.jalz.2019.06.4950},
  pmid    = {31473137},
  url     = {https://doi.org/10.1016/j.jalz.2019.06.4950}
}

@article{rabin2022-35759327,
  author  = {Rabin, J. S. and Nichols, E. and La Joie, R. and Casaletto, K. B. and Palta, P. and Dams-O'Connor, K. and Kumar, R. G. and George, K. M. and others},
  title   = {{Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awac178},
  pmid    = {35759327},
  url     = {https://doi.org/10.1093/brain/awac178}
}

@article{eliassonnenschein2011-21493755,
  author  = {Elias-Sonnenschein, L. S. and Viechtbauer, W. and Ramakers, I. H. and Verhey, F. R. and Visser, P. J.},
  title   = {{Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2011},
  doi     = {10.1136/jnnp.2010.231555},
  pmid    = {21493755},
  url     = {https://doi.org/10.1136/jnnp.2010.231555}
}

@article{meyerluehmann2008-18256671,
  author  = {Meyer-Luehmann, M. and Spires-Jones, T. L. and Prada, C. and Garcia-Alloza, M. and de Calignon, A. and Rozkalne, A. and Koenigsknecht-Talboo, J. and Holtzman, D. M. and others},
  title   = {{Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease}},
  journal = {Nature},
  year    = {2008},
  doi     = {10.1038/nature06616},
  pmid    = {18256671},
  url     = {https://doi.org/10.1038/nature06616}
}

@article{jansen2019-30617256,
  author  = {Jansen, Iris E. and Savage, Jeanne E. and Watanabe, Kyoko and Bryois, Julien and Williams, Dylan M. and Steinberg, Stacy and Sealock, Julia and Karlsson, Ida and others},
  title   = {{Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk}},
  journal = {Nature Genetics},
  year    = {2019},
  doi     = {10.1038/s41588-018-0311-9},
  pmid    = {30617256},
  url     = {https://doi.org/10.1038/s41588-018-0311-9}
}

@article{ferrarisouza2026-41198899,
  author  = {Ferrari-Souza, J. P. and Povala, G. and Rahmouni, N. and Bellaver, B. and Ferreira, P. C. L. and De Bastiani, M. A. and Leffa, D. T. and Lussier, F. Z. and Aguzzoli, C. S. and Brum, W. S. and Carello-Collar, G. and Borelli, W. V. and others},
  title   = {{Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease}},
  journal = {Nature Neuroscience},
  year    = {2026},
  doi     = {10.1038/s41593-025-02103-0},
  pmid    = {41198899},
  url     = {https://doi.org/10.1038/s41593-025-02103-0}
}

@article{karanth2020-32568358,
  author  = {Karanth, S. and Nelson, P. T. and Katsumata, Y. and Kryscio, R. J. and Schmitt, F. A. and Fardo, D. W. and Cykowski, M. D. and Jicha, G. A. and others},
  title   = {{Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.1741},
  pmid    = {32568358},
  url     = {https://doi.org/10.1001/jamaneurol.2020.1741}
}

@article{lim2017-28794245,
  author  = {Lim, Y. Y. and Mormino, E. C. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{APOE genotype and early β-amyloid accumulation in older adults without dementia}},
  journal = {Neurology},
  year    = {2017},
  doi     = {10.1212/wnl.0000000000004336},
  pmid    = {28794245},
  url     = {https://doi.org/10.1212/wnl.0000000000004336}
}

@article{murray2015-25805643,
  author  = {Murray, M. E. and Lowe, V. J. and Graff-Radford, N. R. and Liesinger, A. M. and Cannon, A. and Przybelski, S. A. and Rawal, B. and Parisi, J. E. and others},
  title   = {{Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum}},
  journal = {Brain : a journal of neurology},
  year    = {2015},
  doi     = {10.1093/brain/awv050},
  pmid    = {25805643},
  url     = {https://doi.org/10.1093/brain/awv050}
}

@article{lim2018-29356823,
  author  = {Lim, Y. Y. and Kalinowski, P. and Pietrzak, R. H. and Laws, S. M. and Burnham, S. C. and Ames, D. and Villemagne, V. L. and Fowler, C. J. and others},
  title   = {{Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2017.4325},
  pmid    = {29356823},
  url     = {https://doi.org/10.1001/jamaneurol.2017.4325}
}

@article{carrasquillo2010-20554627,
  author  = {Carrasquillo, M. M. and Belbin, O. and Hunter, T. A. and Ma, L. and Bisceglio, G. D. and Zou, F. and Crook, J. E. and others},
  title   = {{Replication of CLU, CR1, and PICALM associations with alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2010.147},
  pmid    = {20554627},
  url     = {https://doi.org/10.1001/archneurol.2010.147}
}

@article{reitz2011-21220680,
  author  = {Reitz, C. and Cheng, R. and Rogaeva, E. and Lee, J. H. and Tokuhiro, S. and Zou, F. and Bettens, K. and Sleegers, K. and others},
  title   = {{Meta-analysis of the association between variants in SORL1 and Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.346},
  pmid    = {21220680},
  url     = {https://doi.org/10.1001/archneurol.2010.346}
}

@article{saddiki2020-32817639,
  author  = {Saddiki, H. and Fayosse, A. and Cognat, E. and Sabia, S. and Engelborghs, S. and Wallon, D. and Alexopoulos, P. and Blennow, K. and others},
  title   = {{Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study}},
  journal = {PLoS medicine},
  year    = {2020},
  doi     = {10.1371/journal.pmed.1003289},
  pmid    = {32817639},
  url     = {https://doi.org/10.1371/journal.pmed.1003289}
}

@article{harold2009-19734902,
  author  = {Harold, Denise H. and Abraham, Richard and Hollingworth, Paul and Sims, Rebecca and Gerrish, Amy and Hamshere, Marian L. and Pahwa, Jaspreet Singh and Moskvina, Valentina and others},
  title   = {{Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2009},
  doi     = {10.1038/ng.440},
  pmid    = {19734902},
  url     = {https://doi.org/10.1038/ng.440}
}

@article{study2011-21460840,
  author  = {{the Alzheimer's Disease Neuroimaging Initiative} and Hollingworth, Paul and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Lambert, Jean‐Charles and Carrasquillo, Minerva M. and Abraham, Richard and others},
  title   = {{Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2011},
  doi     = {10.1038/ng.803},
  pmid    = {21460840},
  url     = {https://doi.org/10.1038/ng.803}
}

@article{vanolst2025-40050704,
  author  = {van Olst, L. and Simonton, B. and Edwards, A. J. and Forsyth, A. V. and Boles, J. and Jamshidi, P. and Watson, T. and Shepard, N. and Krainc, T. and Argue, B. M. and Zhang, Z. and Kuruvilla, J. and others},
  title   = {{Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease}},
  journal = {Nature Medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03574-1},
  pmid    = {40050704},
  url     = {https://doi.org/10.1038/s41591-025-03574-1}
}

@article{schrijvers2010-21115952,
  author  = {Schrijvers, E. M. and Witteman, J. C. and Sijbrands, E. J. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.},
  title   = {{Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181ffe4f6},
  pmid    = {21115952},
  url     = {https://doi.org/10.1212/wnl.0b013e3181ffe4f6}
}

@article{mormino2014-24748674,
  author  = {Mormino, E. C. and Betensky, R. A. and Hedden, T. and Schultz, A. P. and Ward, A. and Huijbers, W. and Rentz, D. M. and Johnson, K. A. and others},
  title   = {{Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000431},
  pmid    = {24748674},
  url     = {https://doi.org/10.1212/wnl.0000000000000431}
}

@article{pietrzak2015-25629787,
  author  = {Pietrzak, R. H. and Lim, Y. Y. and Neumeister, A. and Ames, D. and Ellis, K. A. and Harrington, K. and Lautenschlager, N. T. and Restrepo, C. and others},
  title   = {{Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study}},
  journal = {JAMA psychiatry},
  year    = {2015},
  doi     = {10.1001/jamapsychiatry.2014.2476},
  pmid    = {25629787},
  url     = {https://doi.org/10.1001/jamapsychiatry.2014.2476}
}

@article{jin2021-34061824,
  author  = {Jin, X. and He, W. and Zhang, Y. and Gong, E. and Niu, Z. and Ji, J. and Li, Y. and Zeng, Y. and others},
  title   = {{Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study}},
  journal = {PLoS medicine},
  year    = {2021},
  doi     = {10.1371/journal.pmed.1003597},
  pmid    = {34061824},
  url     = {https://doi.org/10.1371/journal.pmed.1003597}
}

@article{morris2016-26836731,
  author  = {Morris, M. C. and Brockman, J. and Schneider, J. A. and Wang, Y. and Bennett, D. A. and Tangney, C. C. and van de Rest, O.},
  title   = {{Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults}},
  journal = {JAMA},
  year    = {2016},
  doi     = {10.1001/jama.2015.19451},
  pmid    = {26836731},
  url     = {https://doi.org/10.1001/jama.2015.19451}
}

@article{depp2023-37258678,
  author  = {Depp, C. and Sun, T. and Sasmita, A. O. and Spieth, L. and Berghoff, S. A. and Nazarenko, T. and Overhoff, K. and Steixner-Kumar, A. A. and others},
  title   = {{Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease}},
  journal = {Nature},
  year    = {2023},
  doi     = {10.1038/s41586-023-06120-6},
  pmid    = {37258678},
  url     = {https://doi.org/10.1038/s41586-023-06120-6}
}

@article{leung2013-23762274,
  author  = {Leung, R. and Proitsi, P. and Simmons, A. and Lunnon, K. and Güntert, A. and Kronenberg, D. and Pritchard, M. and Tsolaki, M. and others},
  title   = {{Inflammatory proteins in plasma are associated with severity of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0064971},
  pmid    = {23762274},
  url     = {https://doi.org/10.1371/journal.pone.0064971}
}

@article{insel2020-32140682,
  author  = {Insel, P. S. and Mormino, E. C. and Aisen, P. S. and Thompson, W. K. and Donohue, M. C.},
  title   = {{Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention}},
  journal = {Brain communications},
  year    = {2020},
  doi     = {10.1093/braincomms/fcaa007},
  pmid    = {32140682},
  url     = {https://doi.org/10.1093/braincomms/fcaa007}
}

@article{duff2025-39885359,
  author  = {Duff, E. P. and Zetterberg, H. and Heslegrave, A. and Dehghan, A. and Elliott, P. and Allen, N. and Runz, H. and Laban, R. and others},
  title   = {{Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection}},
  journal = {Nature medicine},
  year    = {2025},
  doi     = {10.1038/s41591-024-03426-4},
  pmid    = {39885359},
  url     = {https://doi.org/10.1038/s41591-024-03426-4}
}

@article{ray2025-40096060,
  author  = {Ray, Nicholas R. and Bradley, Joseph L. and Yılmaz, Elanur and Kızıl, Çağhan and Kurup, Jiji Thulaseedhara and Martin, Eden R. and Klein, Hans‐Ulrich and Kunkle, Brian W. and others},
  title   = {{Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease}},
  journal = {PLoS Genetics},
  year    = {2025},
  doi     = {10.1371/journal.pgen.1011631},
  pmid    = {40096060},
  url     = {https://doi.org/10.1371/journal.pgen.1011631}
}

@article{delva2025-39761530,
  author  = {Delva, Aline and Pelletier, Amélie and Somerville, Emma N. and Montplaisir, Jacques Yves and Gagnon, Jean‐François and Kollmorgen, Gwendlyn and Kam‐Thong, Tony and Kustermann, Thomas and others},
  title   = {{Plasma pTau181 and amyloid markers predict conversion to dementia in idiopathic REM sleep behaviour disorder}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awaf003},
  pmid    = {39761530},
  url     = {https://doi.org/10.1093/brain/awaf003}
}

@article{saunders1993-8350998,
  author  = {Saunders, Ann M. and Strittmatter, Warren J. and Schmechel, D. E. and George‐Hyslop, Peter St and Vance, Jeffery M. and Joo, S. H. and Rosi, B.L. and Gusella, James F. and others},
  title   = {{Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease}},
  journal = {Neurology},
  year    = {1993},
  doi     = {10.1212/wnl.43.8.1467},
  pmid    = {8350998},
  url     = {https://doi.org/10.1212/wnl.43.8.1467}
}

@article{barral2025-40219824,
  author  = {Barral, S. and Yang, Z. and Phillips, N. and Barber, R. C. and Brickman, A. M. and Honig, L. S. and Cieza, B. and Reyes-Dumeyer, D. and Mayeux, R. and Rajabli, F. and others},
  title   = {{APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos}},
  journal = {Alzheimer's \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70138},
  pmid    = {40219824},
  url     = {https://doi.org/10.1002/alz.70138}
}

@article{kamagata2022-36123122,
  author  = {Kamagata, K. and Andica, C. and Takabayashi, K. and Saito, Y. and Taoka, T. and Nozaki, H. and Kikuta, J. and Fujita, S. and others},
  title   = {{Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000201300},
  pmid    = {36123122},
  url     = {https://doi.org/10.1212/wnl.0000000000201300}
}

@article{lim2013-24145819,
  author  = {Lim, A. S. and Yu, L. and Kowgier, M. and Schneider, J. A. and Buchman, A. S. and Bennett, D. A.},
  title   = {{Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.4215},
  pmid    = {24145819},
  url     = {https://doi.org/10.1001/jamaneurol.2013.4215}
}

@article{brouwers2012-21403675,
  author  = {Brouwers, N. and Van Cauwenberghe, C. and Engelborghs, S. and Lambert, J. C. and Bettens, K. and Le Bastard, N. and Pasquier, F. and Montoya, A. G. and others},
  title   = {{Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites}},
  journal = {Molecular psychiatry},
  year    = {2012},
  doi     = {10.1038/mp.2011.24},
  pmid    = {21403675},
  url     = {https://doi.org/10.1038/mp.2011.24}
}

@article{ge2018-29592889,
  author  = {Ge, T. and Sabuncu, M. R. and Smoller, J. W. and Sperling, R. A. and Mormino, E. C. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000005415},
  pmid    = {29592889},
  url     = {https://doi.org/10.1212/wnl.0000000000005415}
}

@article{steele2017-28350795,
  author  = {Steele, N. Z. and Carr, J. S. and Bonham, L. W. and Geier, E. G. and Damotte, V. and Miller, Z. A. and Desikan, R. S. and Boehme, K. L. and others},
  title   = {{Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study}},
  journal = {PLoS medicine},
  year    = {2017},
  doi     = {10.1371/journal.pmed.1002272},
  pmid    = {28350795},
  url     = {https://doi.org/10.1371/journal.pmed.1002272}
}

@article{vanes2009-19734901,
  author  = {van Es, M. A. and Veldink, J. H. and Saris, C. G. and Blauw, H. M. and van Vught, P. W. and Birve, A. and Lemmens, R. and Schelhaas, H. J. and others},
  title   = {{Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis}},
  journal = {Nature genetics},
  year    = {2009},
  doi     = {10.1038/ng.442},
  pmid    = {19734901},
  url     = {https://doi.org/10.1038/ng.442}
}

@article{haran2019-31064831,
  author  = {Haran, J. P. and Bhattarai, S. K. and Foley, S. E. and Dutta, P. and Ward, D. V. and Bucci, V. and McCormick, B. A.},
  title   = {{Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway}},
  journal = {mBio},
  year    = {2019},
  doi     = {10.1128/mbio.00632-19},
  pmid    = {31064831},
  url     = {https://doi.org/10.1128/mbio.00632-19}
}

@article{lanoiselee2017-28350801,
  author  = {Lanoiselée, H. M. and Nicolas, G. and Wallon, D. and Rovelet-Lecrux, A. and Lacour, M. and Rousseau, S. and Richard, A. C. and Pasquier, F. and others},
  title   = {{APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases}},
  journal = {PLoS medicine},
  year    = {2017},
  doi     = {10.1371/journal.pmed.1002270},
  pmid    = {28350801},
  url     = {https://doi.org/10.1371/journal.pmed.1002270}
}

@article{li2015-26202100,
  author  = {Li, X. and Long, J. and He, T. and Belshaw, R. and Scott, J.},
  title   = {{Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2015},
  doi     = {10.1038/srep12393},
  pmid    = {26202100},
  url     = {https://doi.org/10.1038/srep12393}
}

@article{study2009-591259cf,
  author  = {{the European Alzheimer's Disease Initiative Investigators} and Lambert, Jean‐Charles and Heath, Simon Charles and Even, Gaël and Campion, Dominique and Sleegers, Kristel and Hiltunen, Mikko and Combarros, Onofre and others},
  title   = {{Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2009},
  doi     = {10.1038/ng.439},
  url     = {https://doi.org/10.1038/ng.439}
}

@article{vassar1999-10531052,
  author  = {Vassar, Robert J. and Bennett, Brian D. and Babu‐Khan, Safura and Kahn, Steve and Mendiaz, Elizabeth A. and Denis, Paul E. and Teplow, David B. and Ross, Sandra L. and others},
  title   = {{β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE}},
  journal = {Science},
  year    = {1999},
  doi     = {10.1126/science.286.5440.735},
  pmid    = {10531052},
  url     = {https://doi.org/10.1126/science.286.5440.735}
}

@article{langbaum2025-41319675,
  author  = {Langbaum, J. B. and Bradbury, A. R. and Egleston, B. L. and McCarty Wood, E. and Langlois, C. M. and Largent, E. A. and Harkins, K. and Erickson, C. M. and Stites, S. D. and Oyen, E. and others},
  title   = {{Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1}},
  journal = {The Lancet Healthy Longevity},
  year    = {2025},
  doi     = {10.1016/j.lanhl.2025.100778},
  pmid    = {41319675},
  url     = {https://doi.org/10.1016/j.lanhl.2025.100778}
}

@article{raya2026-41729539,
  author  = {Raya, Maison Abu and Suemoto, Claudia Kimie and Paes, Vitor Ribeiro and Leite, Renata Elaine Paraizo and Pasqualucci, Carlos Augusto and Naslavsky, Michel Satya and Rodriguez, Roberta Diehl and Nitrini, Ricardo and others},
  title   = {{Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample}},
  journal = {JAMA neurology},
  year    = {2026},
  doi     = {10.1001/jamaneurol.2026.0054},
  pmid    = {41729539},
  url     = {https://doi.org/10.1001/jamaneurol.2026.0054}
}

@article{jack2015-25775353,
  author  = {Jack, C. R. and Wiste, H. J. and Weigand, S. D. and Knopman, D. S. and Vemuri, P. and Mielke, M. M. and Lowe, V. and Senjem, M. L. and others},
  title   = {{Age, Sex, and APOE ε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.4821},
  pmid    = {25775353},
  url     = {https://doi.org/10.1001/jamaneurol.2014.4821}
}

@article{roberts2014-24652830,
  author  = {Roberts, R. O. and Knopman, D. S. and Cha, R. H. and Mielke, M. M. and Pankratz, V. S. and Boeve, B. F. and Kantarci, K. and Geda, Y. E. and others},
  title   = {{Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2014},
  doi     = {10.2967/jnumed.113.132647},
  pmid    = {24652830},
  url     = {https://doi.org/10.2967/jnumed.113.132647}
}

@article{tao2018-30646251,
  author  = {Tao, Q. and Ang, T. F. A. and DeCarli, C. and Auerbach, S. H. and Devine, S. and Stein, T. D. and Zhang, X. and Massaro, J. and others},
  title   = {{Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers}},
  journal = {JAMA network open},
  year    = {2018},
  doi     = {10.1001/jamanetworkopen.2018.3597},
  pmid    = {30646251},
  url     = {https://doi.org/10.1001/jamanetworkopen.2018.3597}
}

@article{rajabli2018-30517106,
  author  = {Rajabli, F. and Feliciano, B. E. and Celis, K. and Hamilton-Nelson, K. L. and Whitehead, P. L. and Adams, L. D. and Bussies, P. L. and Manrique, C. P. and others},
  title   = {{Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations}},
  journal = {PLoS genetics},
  year    = {2018},
  doi     = {10.1371/journal.pgen.1007791},
  pmid    = {30517106},
  url     = {https://doi.org/10.1371/journal.pgen.1007791}
}

@article{desikan2015-25862742,
  author  = {Desikan, R. S. and Schork, A. J. and Wang, Y. and Thompson, W. K. and Dehghan, A. and Ridker, P. M. and Chasman, D. I. and McEvoy, L. K. and others},
  title   = {{Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease}},
  journal = {Circulation},
  year    = {2015},
  doi     = {10.1161/circulationaha.115.015489},
  pmid    = {25862742},
  url     = {https://doi.org/10.1161/circulationaha.115.015489}
}

@article{delcampo2016-26643548,
  author  = {Del Campo, N. and Payoux, P. and Djilali, A. and Delrieu, J. and Hoogendijk, E. O. and Rolland, Y. and Cesari, M. and Weiner, M. W. and others},
  title   = {{Relationship of regional brain β-amyloid to gait speed}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000002235},
  pmid    = {26643548},
  url     = {https://doi.org/10.1212/wnl.0000000000002235}
}

@article{kreisl2013-23775979,
  author  = {Kreisl, W. C. and Lyoo, C. H. and McGwier, M. and Snow, J. and Jenko, K. J. and Kimura, N. and Corona, W. and Morse, C. L. and others},
  title   = {{In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2013},
  doi     = {10.1093/brain/awt145},
  pmid    = {23775979},
  url     = {https://doi.org/10.1093/brain/awt145}
}

@article{gomperts2013-23243071,
  author  = {Gomperts, S. N. and Locascio, J. J. and Rentz, D. and Santarlasci, A. and Marquie, M. and Johnson, K. A. and Growdon, J. H.},
  title   = {{Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia}},
  journal = {Neurology},
  year    = {2013},
  doi     = {10.1212/wnl.0b013e31827b1a07},
  pmid    = {23243071},
  url     = {https://doi.org/10.1212/wnl.0b013e31827b1a07}
}

@article{atherton2022-35759276,
  author  = {Atherton, K. and Han, X. and Chung, J. and Cherry, J. D. and Baucom, Z. and Saltiel, N. and Nair, E. and Abdolmohammadi, B. and others},
  title   = {{Association of APOE Genotypes and Chronic Traumatic Encephalopathy}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.1634},
  pmid    = {35759276},
  url     = {https://doi.org/10.1001/jamaneurol.2022.1634}
}

@article{paranjpe2021-34658838,
  author  = {Paranjpe, M. D. and Belonwu, S. and Wang, J. K. and Oskotsky, T. and Gupta, A. and Taubes, A. and Zalocusky, K. A. and Paranjpe, I. and others},
  title   = {{Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.735611},
  pmid    = {34658838},
  url     = {https://doi.org/10.3389/fnagi.2021.735611}
}

@article{sparksstein2012-22546352,
  author  = {Sparks Stein, P. and Steffen, M. J. and Smith, C. and Jicha, G. and Ebersole, J. L. and Abner, E. and Dawson, D.},
  title   = {{Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2012},
  doi     = {10.1016/j.jalz.2011.04.006},
  pmid    = {22546352},
  url     = {https://doi.org/10.1016/j.jalz.2011.04.006}
}

@article{huijbers2015-25678559,
  author  = {Huijbers, W. and Mormino, E. C. and Schultz, A. P. and Wigman, S. and Ward, A. M. and Larvie, M. and Amariglio, R. E. and Marshall, G. A. and others},
  title   = {{Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression}},
  journal = {Brain : a journal of neurology},
  year    = {2015},
  doi     = {10.1093/brain/awv007},
  pmid    = {25678559},
  url     = {https://doi.org/10.1093/brain/awv007}
}

@article{hu2011-21390209,
  author  = {Hu, X. and Pickering, E. and Liu, Y. C. and Hall, S. and Fournier, H. and Katz, E. and Dechairo, B. and John, S. and others},
  title   = {{Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease}},
  journal = {PloS one},
  year    = {2011},
  doi     = {10.1371/journal.pone.0016616},
  pmid    = {21390209},
  url     = {https://doi.org/10.1371/journal.pone.0016616}
}

@article{gottesman2020-31860001,
  author  = {Gottesman, R. F. and Mosley, T. H. and Knopman, D. S. and Hao, Q. and Wong, D. and Wagenknecht, L. E. and Hughes, T. M. and Qiao, Y. and others},
  title   = {{Association of Intracranial Atherosclerotic Disease With Brain β-Amyloid Deposition: Secondary Analysis of the ARIC Study}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2019.4339},
  pmid    = {31860001},
  url     = {https://doi.org/10.1001/jamaneurol.2019.4339}
}

@article{walker2021-37118015,
  author  = {Walker, K. A. and Chen, J. and Zhang, J. and Fornage, M. and Yang, Y. and Zhou, L. and Grams, M. E. and Tin, A. and others},
  title   = {{Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk}},
  journal = {Nature aging},
  year    = {2021},
  doi     = {10.1038/s43587-021-00064-0},
  pmid    = {37118015},
  url     = {https://doi.org/10.1038/s43587-021-00064-0}
}

@article{serranopozo2013-23656989,
  author  = {Serrano-Pozo, A. and Muzikansky, A. and Gómez-Isla, T. and Growdon, J. H. and Betensky, R. A. and Frosch, M. P. and Hyman, B. T.},
  title   = {{Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2013},
  doi     = {10.1097/nen.0b013e3182933788},
  pmid    = {23656989},
  url     = {https://doi.org/10.1097/nen.0b013e3182933788}
}

@article{grill2026-41910973,
  author  = {Grill, Joshua D. and RAMAN, REMA and Wang, Shunran and Ernstrom, Karin B. and Andrews, Patricia and Appleby, Brian Stephen and Bhangu, Jaspreet S. and Dhadda, Shobha and others},
  title   = {{Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress}},
  journal = {JAMA Network Open},
  year    = {2026},
  doi     = {10.1001/jamanetworkopen.2026.3845},
  pmid    = {41910973},
  url     = {https://doi.org/10.1001/jamanetworkopen.2026.3845}
}

@article{oddo2003-12895417,
  author  = {Oddo, Salvatore and Caccamo, Antonella and Shepherd, Jason D. and Murphy, Michael Paul and Golde, Todd Eliot and Kayed, Rakez and Metherate, Raju and Mattson, Mark P. and others},
  title   = {{Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00434-3},
  pmid    = {12895417},
  url     = {https://doi.org/10.1016/s0896-6273(03)00434-3}
}

@article{schultz2024-39074479,
  author  = {Schultz, S. A. and Liu, L. and Schultz, A. P. and Fitzpatrick, C. D. and Levin, R. and Bellier, J. P. and Shirzadi, Z. and Joseph-Mathurin, N. and others},
  title   = {{γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)}},
  journal = {The Lancet. Neurology},
  year    = {2024},
  doi     = {10.1016/s1474-4422(24)00236-9},
  pmid    = {39074479},
  url     = {https://doi.org/10.1016/s1474-4422(24)00236-9}
}

@article{shankar2008-18568035,
  author  = {Shankar, Ganesh M. and Li, Shaomin and Mehta, Tapan and García-Muñoz, Amaya and Shepardson, Nina E. and Smith, Imelda M. and Brett, Francesca M. and Farrell, Michael Anthony and Rowan, Michael J. and Lemere, Cynthia Ann and Regan, Ciaran M. and Walsh, Dominic M. and Sabatini, Bernardo Luis and Selkoe, Dennis J.},
  title   = {{Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory}},
  journal = {Nature Medicine},
  year    = {2008},
  doi     = {10.1038/nm1782},
  pmid    = {18568035},
  url     = {https://doi.org/10.1038/nm1782}
}

@article{heneka2013-23254930,
  author  = {Heneka, M. T. and Kummer, M. P. and Stutz, A. and Delekate, A. and Schwartz, S. and Vieira-Saecker, A. and Griep, A. and Axt, D. and others},
  title   = {{NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice}},
  journal = {Nature},
  year    = {2013},
  doi     = {10.1038/nature11729},
  pmid    = {23254930},
  url     = {https://doi.org/10.1038/nature11729}
}

@article{chiao2019-29777003,
  author  = {Chiao, P. and Bedell, B. J. and Avants, B. and Zijdenbos, A. P. and Grand'Maison, M. and O'Neill, P. and O'Gorman, J. and Chen, T. and others},
  title   = {{Impact of Reference and Target Region Selection on Amyloid PET SUV Ratios in the Phase 1b PRIME Study of Aducanumab}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2019},
  doi     = {10.2967/jnumed.118.209130},
  pmid    = {29777003},
  url     = {https://doi.org/10.2967/jnumed.118.209130}
}

@article{morris2010-20186853,
  author  = {Morris, J. C. and Roe, C. M. and Xiong, C. and Fagan, A. M. and Goate, A. M. and Holtzman, D. M. and Mintun, M. A.},
  title   = {{APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.21843},
  pmid    = {20186853},
  url     = {https://doi.org/10.1002/ana.21843}
}

@article{allen2012-22722634,
  author  = {Allen, M. and Zou, F. and Chai, H. S. and Younkin, C. S. and Crook, J. and Pankratz, V. S. and Carrasquillo, M. M. and Rowley, C. N. and others},
  title   = {{Novel late-onset Alzheimer disease loci variants associate with brain gene expression}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e3182605801},
  pmid    = {22722634},
  url     = {https://doi.org/10.1212/wnl.0b013e3182605801}
}

@article{hall2006-16434658,
  author  = {Hall, K. and Murrell, J. and Ogunniyi, A. and Deeg, M. and Baiyewu, O. and Gao, S. and Gureje, O. and Dickens, J. and others},
  title   = {{Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000194507.39504.17},
  pmid    = {16434658},
  url     = {https://doi.org/10.1212/01.wnl.0000194507.39504.17}
}

@article{mokry2016-27856775,
  author  = {Mokry, L. E. and Ross, S. and Morris, J. A. and Manousaki, D. and Forgetta, V. and Richards, J. B.},
  title   = {{Genetically decreased vitamin D and risk of Alzheimer disease}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000003430},
  pmid    = {27856775},
  url     = {https://doi.org/10.1212/wnl.0000000000003430}
}

@article{proitsi2014-25226301,
  author  = {Proitsi, P. and Lupton, M. K. and Velayudhan, L. and Newhouse, S. and Fogh, I. and Tsolaki, M. and Daniilidou, M. and Pritchard, M. and others},
  title   = {{Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis}},
  journal = {PLoS medicine},
  year    = {2014},
  doi     = {10.1371/journal.pmed.1001713},
  pmid    = {25226301},
  url     = {https://doi.org/10.1371/journal.pmed.1001713}
}

@article{ringman2014-24797962,
  author  = {Ringman, J. M. and Sachs, M. C. and Zhou, Y. and Monsell, S. E. and Saver, J. L. and Vinters, H. V.},
  title   = {{Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.681},
  pmid    = {24797962},
  url     = {https://doi.org/10.1001/jamaneurol.2014.681}
}

@article{liu2019-31063846,
  author  = {Liu, P. and Wu, L. and Peng, G. and Han, Y. and Tang, R. and Ge, J. and Zhang, L. and Jia, L. and others},
  title   = {{Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort}},
  journal = {Brain, behavior, and immunity},
  year    = {2019},
  doi     = {10.1016/j.bbi.2019.05.008},
  pmid    = {31063846},
  url     = {https://doi.org/10.1016/j.bbi.2019.05.008}
}

@article{goetzl2015-26062630,
  author  = {Goetzl, E. J. and Boxer, A. and Schwartz, J. B. and Abner, E. L. and Petersen, R. C. and Miller, B. L. and Kapogiannis, D.},
  title   = {{Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000001702},
  pmid    = {26062630},
  url     = {https://doi.org/10.1212/wnl.0000000000001702}
}

@article{deng2011-21857683,
  author  = {Deng, H. X. and Chen, W. and Hong, S. T. and Boycott, K. M. and Gorrie, G. H. and Siddique, N. and Yang, Y. and Fecto, F. and others},
  title   = {{Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia}},
  journal = {Nature},
  year    = {2011},
  doi     = {10.1038/nature10353},
  pmid    = {21857683},
  url     = {https://doi.org/10.1038/nature10353}
}

@article{fiandaca2015-25130657,
  author  = {Fiandaca, M. S. and Kapogiannis, D. and Mapstone, M. and Boxer, A. and Eitan, E. and Schwartz, J. B. and Abner, E. L. and Petersen, R. C. and others},
  title   = {{Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.06.008},
  pmid    = {25130657},
  url     = {https://doi.org/10.1016/j.jalz.2014.06.008}
}

@article{jun2014-25043464,
  author  = {Jun, G. and Asai, H. and Zeldich, E. and Drapeau, E. and Chen, C. and Chung, J. and Park, J. H. and Kim, S. and others},
  title   = {{PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation}},
  journal = {Annals of neurology},
  year    = {2014},
  doi     = {10.1002/ana.24219},
  pmid    = {25043464},
  url     = {https://doi.org/10.1002/ana.24219}
}

@article{kang2009-19779148,
  author  = {Kang, Jae-Eun and Lim, Miranda M. and Bateman, Randall John and Lee, James J. and Smyth, Liam P. and Cirrito, John R. and Fujiki, Nobuhiro and Nishino, Seiji and Holtzman, David M.},
  title   = {{Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle}},
  journal = {Science},
  year    = {2009},
  doi     = {10.1126/science.1180962},
  pmid    = {19779148},
  url     = {https://doi.org/10.1126/science.1180962}
}

@article{dickson2018-30143564,
  author  = {Dickson, D. W. and Heckman, M. G. and Murray, M. E. and Soto, A. I. and Walton, R. L. and Diehl, N. N. and van Gerpen, J. A. and Uitti, R. J. and others},
  title   = {{APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000006212},
  pmid    = {30143564},
  url     = {https://doi.org/10.1212/wnl.0000000000006212}
}

@article{richardson2014-24473795,
  author  = {Richardson, JR. and Roy, A. and Shalat, S. L. and von Stein, R. T. and Hossain, M. M. and Buckley, B. and Gearing, M. and Levey, A. I. and others},
  title   = {{Elevated serum pesticide levels and risk for Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.6030},
  pmid    = {24473795},
  url     = {https://doi.org/10.1001/jamaneurol.2013.6030}
}

@article{yu2017-28108637,
  author  = {Yu, L. and Lutz, M. W. and Wilson, R. S. and Burns, D. K. and Roses, A. D. and Saunders, A. M. and Gaiteri, C. and De Jager, P. L. and others},
  title   = {{TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype}},
  journal = {Neurology},
  year    = {2017},
  doi     = {10.1212/wnl.0000000000003614},
  pmid    = {28108637},
  url     = {https://doi.org/10.1212/wnl.0000000000003614}
}

@article{reiman2020-32015339,
  author  = {Reiman, E. M. and Arboleda-Velasquez, J. F. and Quiroz, Y. T. and Huentelman, M. J. and Beach, T. G. and Caselli, R. J. and Chen, Y. and Su, Y. and others},
  title   = {{Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-019-14279-8},
  pmid    = {32015339},
  url     = {https://doi.org/10.1038/s41467-019-14279-8}
}

@article{dean2017-27842175,
  author  = {Dean, D. C. and Hurley, S. A. and Kecskemeti, SR. and O'Grady, J. P. and Canda, C. and Davenport-Sis, N. J. and Carlsson, C. M. and Zetterberg, H. and others},
  title   = {{Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.3232},
  pmid    = {27842175},
  url     = {https://doi.org/10.1001/jamaneurol.2016.3232}
}

@article{gomezisla1996-8699259,
  author  = {Gómez-Isla, T. and Price, J. L. and McKeel, D. W. and Morris, J. C. and Growdon, J. H. and Hyman, B. T.},
  title   = {{Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1996},
  doi     = {10.1523/jneurosci.16-14-04491.1996},
  pmid    = {8699259},
  url     = {https://doi.org/10.1523/jneurosci.16-14-04491.1996}
}

@article{mayeux1998-9468467,
  author  = {Mayeux, R. and Saunders, A. M. and Shea, S. and Mirra, S. and Evans, D. and Roses, A. D. and Hyman, B. T. and Crain, B. and others},
  title   = {{Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease}},
  journal = {The New England journal of medicine},
  year    = {1998},
  doi     = {10.1056/nejm199802193380804},
  pmid    = {9468467},
  url     = {https://doi.org/10.1056/nejm199802193380804}
}

@article{burns2010-20385908,
  author  = {Burns, J. M. and Johnson, D. K. and Watts, A. and Swerdlow, R. H. and Brooks, W. M.},
  title   = {{Reduced lean mass in early Alzheimer disease and its association with brain atrophy}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2010.38},
  pmid    = {20385908},
  url     = {https://doi.org/10.1001/archneurol.2010.38}
}

@article{johnson2010-21145000,
  author  = {Johnson, J. O. and Mandrioli, J. and Benatar, M. and Abramzon, Y. and Van Deerlin, V. M. and Trojanowski, J. Q. and Gibbs, JR. and Brunetti, M. and others},
  title   = {{Exome sequencing reveals VCP mutations as a cause of familial ALS}},
  journal = {Neuron},
  year    = {2010},
  doi     = {10.1016/j.neuron.2010.11.036},
  pmid    = {21145000},
  url     = {https://doi.org/10.1016/j.neuron.2010.11.036}
}

@article{mormino2009-19042931,
  author  = {Mormino, E. C. and Kluth, J. T. and Madison, C. M. and Rabinovici, G. D. and Baker, S. L. and Miller, B. L. and Koeppe, R. A. and Mathis, C. A. and others},
  title   = {{Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects}},
  journal = {Brain : a journal of neurology},
  year    = {2009},
  doi     = {10.1093/brain/awn320},
  pmid    = {19042931},
  url     = {https://doi.org/10.1093/brain/awn320}
}

@article{rogaeva2007-17220890,
  author  = {Rogaeva, E. and Meng, Y. and Lee, J. H. and Gu, Y. and Kawarai, T. and Zou, F. and Katayama, T. and Baldwin, C. T. and others},
  title   = {{The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease}},
  journal = {Nature genetics},
  year    = {2007},
  doi     = {10.1038/ng1943},
  pmid    = {17220890},
  url     = {https://doi.org/10.1038/ng1943}
}

@article{minhas2024-39172838,
  author  = {Minhas, P. S. and Jones, JR. and Latif-Hernandez, A. and Sugiura, Y. and Durairaj, A. S. and Wang, Q. and Mhatre, S. D. and Uenaka, T. and others},
  title   = {{Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies}},
  journal = {Science (New York, N.Y.)},
  year    = {2024},
  doi     = {10.1126/science.abm6131},
  pmid    = {39172838},
  url     = {https://doi.org/10.1126/science.abm6131}
}

@article{wang2025-40592256,
  author  = {Wang, Tingting and Arnold, Matthias and Huynh, Kevin and Weinisch, Patrick and Giles, Corey and Mellett, Natalie A. and Duong, Thy and Marella, Bharadwaj and others},
  title   = {{Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer's disease: a longitudinal cohort study}},
  journal = {EBioMedicine},
  year    = {2025},
  doi     = {10.1016/j.ebiom.2025.105826},
  pmid    = {40592256},
  url     = {https://doi.org/10.1016/j.ebiom.2025.105826}
}

@article{palmqvist2017-29089479,
  author  = {Palmqvist, Sebastian and Schöll, Michael and Strandberg, Olof T. and Mattsson, Niklas and Stomrud, Erik and Zetterberg, Henrik and Blennow, Kaj and Landau, Susan M. and Jagust, William J. and Hansson, Oskar},
  title   = {{Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity}},
  journal = {Nature Communications},
  year    = {2017},
  doi     = {10.1038/s41467-017-01150-x},
  pmid    = {29089479},
  url     = {https://doi.org/10.1038/s41467-017-01150-x}
}

@article{bradley2025-40556318,
  author  = {Bradley, J. and Pottier, C. and da Fonseca, E. L. and Kurup, J. T. and Western, D. and Wang, C. and Neupane, A. and Ray, N. R. and Jean-Francois, M. and Ali, M. and Timsina, J. and Bergmann, K. and others},
  title   = {{Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways}},
  journal = {Alzheimer's \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70377},
  pmid    = {40556318},
  url     = {https://doi.org/10.1002/alz.70377}
}

@article{jack2013-23446680,
  author  = {Jack, C. R. and Wiste, H. J. and Lesnick, T. G. and Weigand, S. D. and Knopman, D. S. and Vemuri, P. and Pankratz, V. S. and Senjem, M. L. and others},
  title   = {{Brain β-amyloid load approaches a plateau}},
  journal = {Neurology},
  year    = {2013},
  doi     = {10.1212/wnl.0b013e3182840bbe},
  pmid    = {23446680},
  url     = {https://doi.org/10.1212/wnl.0b013e3182840bbe}
}

@article{lajoie2021-33262228,
  author  = {La Joie, R. and Visani, A. V. and Lesman-Segev, O. H. and Baker, S. L. and Edwards, L. and Iaccarino, L. and Soleimani-Meigooni, D. N. and Mellinger, T. and others},
  title   = {{Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000011270},
  pmid    = {33262228},
  url     = {https://doi.org/10.1212/wnl.0000000000011270}
}

@article{cosentino2008-18401023,
  author  = {Cosentino, S. and Scarmeas, N. and Helzner, E. and Glymour, M. M. and Brandt, J. and Albert, M. and Blacker, D. and Stern, Y.},
  title   = {{APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000304038.37421.cc},
  pmid    = {18401023},
  url     = {https://doi.org/10.1212/01.wnl.0000304038.37421.cc}
}

@article{belloy2020-32282020,
  author  = {Belloy, M. E. and Napolioni, V. and Han, S. S. and Le Guen, Y. and Greicius, M. D. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.0414},
  pmid    = {32282020},
  url     = {https://doi.org/10.1001/jamaneurol.2020.0414}
}

@article{nadkarni2017-27842173,
  author  = {Nadkarni, N. K. and Perera, S. and Snitz, B. E. and Mathis, C. A. and Price, J. and Williamson, J. D. and DeKosky, S. T. and Klunk, W. E. and others},
  title   = {{Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.3474},
  pmid    = {27842173},
  url     = {https://doi.org/10.1001/jamaneurol.2016.3474}
}

@article{sanders2010-20068209,
  author  = {Sanders, A. E. and Wang, C. and Katz, M. and Derby, C. A. and Barzilai, N. and Ozelius, L. and Lipton, R. B.},
  title   = {{Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia}},
  journal = {JAMA},
  year    = {2010},
  doi     = {10.1001/jama.2009.1988},
  pmid    = {20068209},
  url     = {https://doi.org/10.1001/jama.2009.1988}
}

@article{piazza2022-35940900,
  author  = {Piazza, F. and Caminiti, S. P. and Zedde, M. and Presotto, L. and DiFrancesco, J. C. and Pascarella, R. and Giossi, A. and others},
  title   = {{Association of Microglial Activation With Spontaneous ARIA-E and CSF Levels of Anti-Aβ Autoantibodies}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000200892},
  pmid    = {35940900},
  url     = {https://doi.org/10.1212/wnl.0000000000200892}
}

@article{ewers2020-32790063,
  author  = {Ewers, M. and Biechele, G. and Suárez-Calvet, M. and Sacher, C. and Blume, T. and Morenas-Rodriguez, E. and Deming, Y. and Piccio, L. and others},
  title   = {{Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation}},
  journal = {EMBO molecular medicine},
  year    = {2020},
  doi     = {10.15252/emmm.202012308},
  pmid    = {32790063},
  url     = {https://doi.org/10.15252/emmm.202012308}
}

@article{tideman2022-35022305,
  author  = {Tideman, P. and Stomrud, E. and Leuzy, A. and Mattsson-Carlgren, N. and Palmqvist, S. and Hansson, O. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000013299},
  pmid    = {35022305},
  url     = {https://doi.org/10.1212/wnl.0000000000013299}
}

@article{lopera2023-37188781,
  author  = {Lopera, F. and Marino, C. and Chandrahas, A. S. and O'Hare, M. and Villalba-Moreno, N. D. and Aguillon, D. and Baena, A. and Sanchez, J. S. and Vila-Castelar, C. and Ramirez Gomez, L. and Chmielewska, N. and Oliveira, G. M. and others},
  title   = {{Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man}},
  journal = {Nature Medicine},
  year    = {2023},
  doi     = {10.1038/s41591-023-02318-3},
  pmid    = {37188781},
  url     = {https://doi.org/10.1038/s41591-023-02318-3}
}

@article{rajabli2023-36539198,
  author  = {Rajabli, F. and Tosto, G. and Hamilton-Nelson, K. L. and Kunkle, B. W. and Vardarajan, B. N. and Naj, A. and Whitehead, P. G. and Gardner, O. K. and Bush, W. S. and Sariya, S. and Mayeux, R. P. and Farrer, L. A. and others},
  title   = {{Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans}},
  journal = {Alzheimer's \& Dementia},
  year    = {2023},
  doi     = {10.1002/alz.12865},
  pmid    = {36539198},
  url     = {https://doi.org/10.1002/alz.12865}
}

@article{oeckl2023-37052206,
  author  = {Oeckl, P. and Bluma, M. and Bucci, M. and Halbgebauer, S. and Chiotis, K. and Sandebring-Matton, A. and Ashton, N. J. and Molfetta, G. D. and others},
  title   = {{Blood β-synuclein is related to amyloid PET positivity in memory clinic patients}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.13046},
  pmid    = {37052206},
  url     = {https://doi.org/10.1002/alz.13046}
}

@article{mancuso2024-38539015,
  author  = {Mancuso, R. and Fattorelli, N. and Martinez-Muriana, A. and Davis, E. and Wolfs, L. and Van Den Daele, J. and Geric, I. and Premereur, J. and others},
  title   = {{Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology}},
  journal = {Nature neuroscience},
  year    = {2024},
  doi     = {10.1038/s41593-024-01600-y},
  pmid    = {38539015},
  url     = {https://doi.org/10.1038/s41593-024-01600-y}
}

@article{cruchaga2012-22312439,
  author  = {Cruchaga, C. and Haller, G. and Chakraverty, S. and Mayo, K. and Vallania, F. L. and Mitra, R. D. and Faber, K. and Williamson, J. and others},
  title   = {{Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0031039},
  pmid    = {22312439},
  url     = {https://doi.org/10.1371/journal.pone.0031039}
}

@article{norgren2026-41854609,
  author  = {Norgren, Jakob and Carballo‐Casla, Adrián and Grande, Giulia and Börjesson‐Hanson, Anne and Xu, Hong and Eriksdotter, Maria and Laukka, Erika J and Ptacek, Sara Garcia},
  title   = {{Meat Consumption and Cognitive Health by APOE Genotype}},
  journal = {JAMA Network Open},
  year    = {2026},
  doi     = {10.1001/jamanetworkopen.2026.6489},
  pmid    = {41854609},
  url     = {https://doi.org/10.1001/jamanetworkopen.2026.6489}
}

@article{suswidiantoro2026-41808871,
  author  = {Suswidiantoro, V. and Tang, K. S. and Rahman, K. and Ariestanti, D. M. and James, R. J. and Yan, C. C. and Kato, M. and Saputri, F. C.},
  title   = {{Natural compounds as multitarget agents in Alzheimer's diseases: evidence from in vivo and in vitro models}},
  journal = {Frontiers in pharmacology},
  year    = {2026},
  doi     = {10.3389/fphar.2026.1766470},
  pmid    = {41808871},
  url     = {https://doi.org/10.3389/fphar.2026.1766470}
}

@article{griciuc2013-23623698,
  author  = {Griciuc, Ana and Serrano‐Pozo, Alberto and Parrado, Antonio and Lesinski, Andrea N. and Asselin, Caroline and Mullin, Kristina and Hooli, Basavaraj V. and Choi, Se Hoon and Hyman, Bradley T. and Tanzi, Rudolph E.},
  title   = {{Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta}},
  journal = {Neuron},
  year    = {2013},
  doi     = {10.1016/j.neuron.2013.04.014},
  pmid    = {23623698},
  url     = {https://doi.org/10.1016/j.neuron.2013.04.014}
}

@article{sperling2009-19640477,
  author  = {Sperling, Reisa Anne and LaViolette, Peter S. and O’Keefe, Kelly and O’Brien, Jacqueline L. and Rentz, Dorene M. and Pihlajamaki, Maija M. and Marshall, Gad A. and Hyman, Bradley T. and Selkoe, Dennis J. and Hedden, Trey and Buckner, Randy Lee and Becker, John Alex and Johnson, Keith A.},
  title   = {{Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia}},
  journal = {Neuron},
  year    = {2009},
  doi     = {10.1016/j.neuron.2009.07.003},
  pmid    = {19640477},
  url     = {https://doi.org/10.1016/j.neuron.2009.07.003}
}

@article{jeong2021-34380754,
  author  = {Jeong, S. H. and Kim, H. R. and Kim, J. and Kim, H. and Hong, N. and Jung, J. H. and Baik, K. and Cho, H. and others},
  title   = {{Association of Dipeptidyl Peptidase-4 Inhibitor Use and Amyloid Burden in Patients With Diabetes and AD-Related Cognitive Impairment}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000012534},
  pmid    = {34380754},
  url     = {https://doi.org/10.1212/wnl.0000000000012534}
}

@article{strittmatter1993-8446617,
  author  = {Strittmatter, W. J. and Saunders, A. M. and Schmechel, D. and Pericak-Vance, M. and Enghild, J. and Salvesen, G. S. and Roses, A. D.},
  title   = {{Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.5.1977},
  pmid    = {8446617},
  url     = {https://doi.org/10.1073/pnas.90.5.1977}
}

@article{buckley2018-29803541,
  author  = {Buckley, R. F. and Mormino, E. C. and Amariglio, R. E. and Properzi, M. J. and Rabin, J. S. and Lim, Y. Y. and Papp, K. V. and Jacobs, H. I. L. and others},
  title   = {{Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2018},
  doi     = {10.1016/j.jalz.2018.04.010},
  pmid    = {29803541},
  url     = {https://doi.org/10.1016/j.jalz.2018.04.010}
}

@article{protas2013-23599929,
  author  = {Protas, H. D. and Chen, K. and Langbaum, J. B. and Fleisher, A. S. and Alexander, G. E. and Lee, W. and Bandy, D. and de Leon, M. J. and others},
  title   = {{Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/2013.jamaneurol.286},
  pmid    = {23599929},
  url     = {https://doi.org/10.1001/2013.jamaneurol.286}
}

@article{vardarajan2015-26101835,
  author  = {Vardarajan, B. N. and Ghani, M. and Kahn, A. and Sheikh, S. and Sato, C. and Barral, S. and Lee, J. H. and Cheng, R. and others},
  title   = {{Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24466},
  pmid    = {26101835},
  url     = {https://doi.org/10.1002/ana.24466}
}

@article{sampedro2015-26397226,
  author  = {Sampedro, F. and Vilaplana, E. and de Leon, M. J. and Alcolea, D. and Pegueroles, J. and Montal, V. and Carmona-Iragui, M. and Sala, I. and others},
  title   = {{APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls}},
  journal = {Oncotarget},
  year    = {2015},
  doi     = {10.18632/oncotarget.5185},
  pmid    = {26397226},
  url     = {https://doi.org/10.18632/oncotarget.5185}
}

@article{darnimrod2012-23079898,
  author  = {Dar-Nimrod, I. and Chapman, B. P. and Franks, P. and Robbins, J. and Porsteinsson, A. and Mapstone, M. and Duberstein, P. R.},
  title   = {{Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2012},
  doi     = {10.1097/jgp.0b013e318267016b},
  pmid    = {23079898},
  url     = {https://doi.org/10.1097/jgp.0b013e318267016b}
}

@article{kivipelto2008-18318693,
  author  = {Kivipelto, M. and Rovio, S. and Ngandu, T. and Kåreholt, I. and Eskelinen, M. and Winblad, B. and Hachinski, V. and Cedazo-Minguez, A. and others},
  title   = {{Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study}},
  journal = {Journal of cellular and molecular medicine},
  year    = {2008},
  doi     = {10.1111/j.1582-4934.2008.00296.x},
  pmid    = {18318693},
  url     = {https://doi.org/10.1111/j.1582-4934.2008.00296.x}
}

@article{lopez2008-18401021,
  author  = {Lopez, O. L. and Kuller, L. H. and Mehta, P. D. and Becker, J. T. and Gach, H. M. and Sweet, R. A. and Chang, Y. F. and Tracy, R. and others},
  title   = {{Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000306696.82017.66},
  pmid    = {18401021},
  url     = {https://doi.org/10.1212/01.wnl.0000306696.82017.66}
}

@article{lee2007-17420311,
  author  = {Lee, J. H. and Cheng, R. and Schupf, N. and Manly, J. and Lantigua, R. and Stern, Y. and Rogaeva, E. and Wakutani, Y. and others},
  title   = {{The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.4.501},
  pmid    = {17420311},
  url     = {https://doi.org/10.1001/archneur.64.4.501}
}

@article{shvetcov2025-40665049,
  author  = {Shvetcov, A. and Johnson, E. C. B. and Winchester, L. M. and Walker, K. A. and Wilkins, H. M. and Thompson, T. G. and Rothstein, J. D. and Krish, V. and others},
  title   = {{APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases}},
  journal = {Nature medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03835-z},
  pmid    = {40665049},
  url     = {https://doi.org/10.1038/s41591-025-03835-z}
}

@article{zhao2020-33139712,
  author  = {Zhao, J. and Fu, Y. and Yamazaki, Y. and Ren, Y. and Davis, M. D. and Liu, C. C. and Lu, W. and Wang, X. and others},
  title   = {{APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-19264-0},
  pmid    = {33139712},
  url     = {https://doi.org/10.1038/s41467-020-19264-0}
}

@article{martens2022-35298921,
  author  = {Martens, Y. A. and Zhao, N. and Liu, C. C. and Kanekiyo, T. and Yang, A. J. and Goate, A. M. and Holtzman, D. M. and Bu, G.},
  title   = {{ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias}},
  journal = {Neuron},
  year    = {2022},
  doi     = {10.1016/j.neuron.2022.03.004},
  pmid    = {35298921},
  url     = {https://doi.org/10.1016/j.neuron.2022.03.004}
}

@article{johnson2014-24686783,
  author  = {Johnson, J. O. and Pioro, E. P. and Boehringer, A. and Chia, R. and Feit, H. and Renton, A. E. and Pliner, H. A. and Abramzon, Y. and others},
  title   = {{Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis}},
  journal = {Nature neuroscience},
  year    = {2014},
  doi     = {10.1038/nn.3688},
  pmid    = {24686783},
  url     = {https://doi.org/10.1038/nn.3688}
}

@article{westin2012-22303443,
  author  = {Westin, K. and Buchhave, P. and Nielsen, H. and Minthon, L. and Janciauskiene, S. and Hansson, O.},
  title   = {{CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0030525},
  pmid    = {22303443},
  url     = {https://doi.org/10.1371/journal.pone.0030525}
}

@article{pickford2008-18497889,
  author  = {Pickford, F. and Masliah, E. and Britschgi, M. and Lucin, K. and Narasimhan, R. and Jaeger, P. A. and Small, S. and Spencer, B. and others},
  title   = {{The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci33585},
  pmid    = {18497889},
  url     = {https://doi.org/10.1172/jci33585}
}

@article{bateman2006-16799555,
  author  = {Bateman, R. J. and Munsell, L. Y. and Morris, J. C. and Swarm, R. and Yarasheski, K. E. and Holtzman, D. M.},
  title   = {{Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo}},
  journal = {Nature medicine},
  year    = {2006},
  doi     = {10.1038/nm1438},
  pmid    = {16799555},
  url     = {https://doi.org/10.1038/nm1438}
}

@article{baligacs2024-39639016,
  author  = {Baligács, N. and Albertini, G. and Borrie, S. C. and Serneels, L. and Pridans, C. and Balusu, S. and De Strooper, B.},
  title   = {{Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer's Disease}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-54779-w},
  pmid    = {39639016},
  url     = {https://doi.org/10.1038/s41467-024-54779-w}
}

@article{grontvedt2022-36413367,
  author  = {Grøntvedt, G. R. and Sando, S. B. and Lauridsen, C. and Bråthen, G. and White, L. R. and Ø, Salvesen and Aarsland, D. and Hessen, E. and others},
  title   = {{Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden}},
  journal = {JAMA network open},
  year    = {2022},
  doi     = {10.1001/jamanetworkopen.2022.43232},
  pmid    = {36413367},
  url     = {https://doi.org/10.1001/jamanetworkopen.2022.43232}
}

@article{salvado2021-33521872,
  author  = {Salvadó, G. and Grothe, M. J. and Groot, C. and Moscoso, A. and Schöll, M. and Gispert, J. D. and Ossenkoppele, R. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2021},
  doi     = {10.1007/s00259-021-05192-8},
  pmid    = {33521872},
  url     = {https://doi.org/10.1007/s00259-021-05192-8}
}

@article{hendriks1992-1303239,
  author  = {Hendriks, L. and van Duijn, C. M. and Cras, P. and Cruts, M. and Van Hul, W. and van Harskamp, F. and Warren, A. and McInnis, M. G. and others},
  title   = {{Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene}},
  journal = {Nature genetics},
  year    = {1992},
  doi     = {10.1038/ng0692-218},
  pmid    = {1303239},
  url     = {https://doi.org/10.1038/ng0692-218}
}

@article{goetzl2018-29406582,
  author  = {Goetzl, E. J. and Schwartz, J. B. and Abner, E. L. and Jicha, G. A. and Kapogiannis, D.},
  title   = {{High complement levels in astrocyte-derived exosomes of Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2018},
  doi     = {10.1002/ana.25172},
  pmid    = {29406582},
  url     = {https://doi.org/10.1002/ana.25172}
}

@article{clocchiattituozzo2025-40549373,
  author  = {Clocchiatti‐Tuozzo, Santiago and Rivier, Cyprien A. and Renedo, Daniela B. and Huo, Shufan and de Havenon, Adam and Hawkes, Maximiliano A. and Gilmore, Emily J. and Schwamm, Lee H. and others},
  title   = {{APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.0182},
  pmid    = {40549373},
  url     = {https://doi.org/10.1001/jamaneurol.2025.0182}
}

@article{chouraki2014-24535457,
  author  = {Chouraki, V. and De Bruijn, R. F. and Chapuis, J. and Bis, J. C. and Reitz, C. and Schraen, S. and Ibrahim-Verbaas, C. A. and Grenier-Boley, B. and others},
  title   = {{A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly}},
  journal = {Molecular psychiatry},
  year    = {2014},
  doi     = {10.1038/mp.2013.185},
  pmid    = {24535457},
  url     = {https://doi.org/10.1038/mp.2013.185}
}

@article{lemche2024-38643861,
  author  = {Lemche, E. and Killick, R. and Mitchell, J. and Caton, P. W. and Choudhary, P. and Howard, J. K.},
  title   = {{Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis}},
  journal = {Neurobiology of disease},
  year    = {2024},
  doi     = {10.1016/j.nbd.2024.106485},
  pmid    = {38643861},
  url     = {https://doi.org/10.1016/j.nbd.2024.106485}
}

@article{kim2009-19679070,
  author  = {Kim, Jungsu and Basak, Jacob M. and Holtzman, David M.},
  title   = {{The Role of Apolipoprotein E in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2009},
  doi     = {10.1016/j.neuron.2009.06.026},
  pmid    = {19679070},
  url     = {https://doi.org/10.1016/j.neuron.2009.06.026}
}

@article{castellano2011-21715678,
  author  = {Castellano, Joseph M. and Kim, Jungsu and Stewart, Floy R. and Jiang, Hong and Demattos, Ronald Bradley and Patterson, Bruce W. and Fagan, Anne M. and Morris, John C. and Mawuenyega, Kwasi G. and Cruchaga, Carlos C and Goate, Alison and Bales, Kelly R. and Paul, Steven M. and Bateman, Randall John and Holtzman, David M.},
  title   = {{Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance}},
  journal = {Science Translational Medicine},
  year    = {2011},
  doi     = {10.1126/scitranslmed.3002156},
  pmid    = {21715678},
  url     = {https://doi.org/10.1126/scitranslmed.3002156}
}

@article{quenez2026-42648288,
  author  = {Quenez, O. and Schramm, C. and Cassinari, K. and Nicolas, A. and Groeneveld, J. and Huguet, G. and Grenier-Boley, B. and Hulsman, M. and Walters, G. B. and de Rojas, I. and Rovelet-Lecrux, A. and Feuillette, S. and others},
  title   = {{Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk}},
  journal = {American Journal of Human Genetics},
  year    = {2026},
  doi     = {10.1016/j.ajhg.2026.07.013},
  pmid    = {42648288},
  url     = {https://doi.org/10.1016/j.ajhg.2026.07.013}
}

@article{brutman2026-41629326,
  author  = {Brutman, J. N. and Busald, T. and Nizamis, E. and Kaufman, E. J. and Lin, E. and Hendricks, N. E. and Chintamen, S. and Sulovari, A. and Smukowski, S. N. and Ye, Y. and Peikon, I. and Jayadev, S. and others},
  title   = {{A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans}},
  journal = {Nature Communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68808-3},
  pmid    = {41629326},
  url     = {https://doi.org/10.1038/s41467-026-68808-3}
}

@article{rodrigue2012-22302550,
  author  = {Rodrigue, K. M. and Kennedy, K. M. and Devous, M. D. and Rieck, JR. and Hebrank, A. C. and Diaz-Arrastia, R. and Mathews, D. and Park, D. C.},
  title   = {{β-Amyloid burden in healthy aging: regional distribution and cognitive consequences}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e318245d295},
  pmid    = {22302550},
  url     = {https://doi.org/10.1212/wnl.0b013e318245d295}
}

@article{thambisetty2010-20065135,
  author  = {Thambisetty, M. and Beason-Held, L. and An, Y. and Kraut, M. A. and Resnick, S. M.},
  title   = {{APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2009.913},
  pmid    = {20065135},
  url     = {https://doi.org/10.1001/archneurol.2009.913}
}

@article{mata2014-25178429,
  author  = {Mata, I. F. and Leverenz, J. B. and Weintraub, D. and Trojanowski, J. Q. and Hurtig, H. I. and Van Deerlin, V. M. and Ritz, B. and Rausch, R. and others},
  title   = {{APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1455},
  pmid    = {25178429},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1455}
}

@article{lee2011-21059989,
  author  = {Lee, J. H. and Cheng, R. and Barral, S. and Reitz, C. and Medrano, M. and Lantigua, R. and Jiménez-Velazquez, I. Z. and Rogaeva, E. and others},
  title   = {{Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.292},
  pmid    = {21059989},
  url     = {https://doi.org/10.1001/archneurol.2010.292}
}

@article{shulman2013-23836404,
  author  = {Shulman, J. M. and Chen, K. and Keenan, B. T. and Chibnik, L. B. and Fleisher, A. and Thiyyagura, P. and Roontiva, A. and McCabe, C. and others},
  title   = {{Genetic susceptibility for Alzheimer disease neuritic plaque pathology}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.2815},
  pmid    = {23836404},
  url     = {https://doi.org/10.1001/jamaneurol.2013.2815}
}

@article{griswold2021-33522086,
  author  = {Griswold, A. J. and Celis, K. and Bussies, P. L. and Rajabli, F. and Whitehead, P. L. and Hamilton-Nelson, K. L. and Beecham, G. W. and Dykxhoorn, D. M. and others},
  title   = {{Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12287},
  pmid    = {33522086},
  url     = {https://doi.org/10.1002/alz.12287}
}

@article{devanand2005-15956169,
  author  = {Devanand, D. P. and Pelton, G. H. and Zamora, D. and Liu, X. and Tabert, M. H. and Goodkind, M. and Scarmeas, N. and Braun, I. and others},
  title   = {{Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment}},
  journal = {Archives of neurology},
  year    = {2005},
  doi     = {10.1001/archneur.62.6.975},
  pmid    = {15956169},
  url     = {https://doi.org/10.1001/archneur.62.6.975}
}

@article{serranopozo2011-21777559,
  author  = {Serrano-Pozo, A. and Mielke, M. L. and Gómez-Isla, T. and Betensky, R. A. and Growdon, J. H. and Frosch, M. P. and Hyman, B. T.},
  title   = {{Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease}},
  journal = {The American journal of pathology},
  year    = {2011},
  doi     = {10.1016/j.ajpath.2011.05.047},
  pmid    = {21777559},
  url     = {https://doi.org/10.1016/j.ajpath.2011.05.047}
}

@article{drzezga2011-21490054,
  author  = {Drzezga, A. and Becker, J. A. and Van Dijk, K. R. and Sreenivasan, A. and Talukdar, T. and Sullivan, C. and Schultz, A. P. and Sepulcre, J. and others},
  title   = {{Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden}},
  journal = {Brain : a journal of neurology},
  year    = {2011},
  doi     = {10.1093/brain/awr066},
  pmid    = {21490054},
  url     = {https://doi.org/10.1093/brain/awr066}
}

@article{mcdonald2010-20403962,
  author  = {Mc Donald, J. M. and Savva, G. M. and Brayne, C. and Welzel, A. T. and Forster, G. and Shankar, G. M. and Selkoe, D. J. and Ince, P. G. and others},
  title   = {{The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia}},
  journal = {Brain : a journal of neurology},
  year    = {2010},
  doi     = {10.1093/brain/awq065},
  pmid    = {20403962},
  url     = {https://doi.org/10.1093/brain/awq065}
}

@article{reiman1996-8592548,
  author  = {Reiman, E. M. and Caselli, R. J. and Yun, L. S. and Chen, K. and Bandy, D. and Minoshima, S. and Thibodeau, S. N. and Osborne, D.},
  title   = {{Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E}},
  journal = {The New England journal of medicine},
  year    = {1996},
  doi     = {10.1056/nejm199603213341202},
  pmid    = {8592548},
  url     = {https://doi.org/10.1056/nejm199603213341202}
}

@article{shen2018-28359566,
  author  = {Shen, Y. and Wang, H. and Sun, Q. and Yao, H. and Keegan, A. P. and Mullan, M. and Wilson, J. and Lista, S. and others},
  title   = {{Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment}},
  journal = {Biological psychiatry},
  year    = {2018},
  doi     = {10.1016/j.biopsych.2017.02.007},
  pmid    = {28359566},
  url     = {https://doi.org/10.1016/j.biopsych.2017.02.007}
}

@article{lupton2016-26973105,
  author  = {Lupton, M. K. and Strike, L. and Hansell, N. K. and Wen, W. and Mather, K. A. and Armstrong, N. J. and Thalamuthu, A. and McMahon, K. L. and others},
  title   = {{The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2015.12.023},
  pmid    = {26973105},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.12.023}
}

@article{li2021-34589742,
  author  = {Li, Q. S. and De Muynck, L.},
  title   = {{Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1}},
  journal = {Brain, behavior, \& immunity - health},
  year    = {2021},
  doi     = {10.1016/j.bbih.2021.100227},
  pmid    = {34589742},
  url     = {https://doi.org/10.1016/j.bbih.2021.100227}
}

@article{vanarendonk2023-36374264,
  author  = {van Arendonk, J. and Neitzel, J. and Steketee, R. M. E. and van Assema, D. M. E. and Vrooman, H. A. and Segbers, M. and Ikram, M. A. and Vernooij, M. W.},
  title   = {{Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awac354},
  pmid    = {36374264},
  url     = {https://doi.org/10.1093/brain/awac354}
}

@article{webster2009-19361613,
  author  = {Webster, J. A. and Gibbs, JR. and Clarke, J. and Ray, M. and Zhang, W. and Holmans, P. and Rohrer, K. and Zhao, A. and others},
  title   = {{Genetic control of human brain transcript expression in Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {2009},
  doi     = {10.1016/j.ajhg.2009.03.011},
  pmid    = {19361613},
  url     = {https://doi.org/10.1016/j.ajhg.2009.03.011}
}

@article{mattsson2014-24625697,
  author  = {Mattsson, N. and Tosun, D. and Insel, P. S. and Simonson, A. and Jack, C. R. and Beckett, L. A. and Donohue, M. and Jagust, W. and others},
  title   = {{Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment}},
  journal = {Brain : a journal of neurology},
  year    = {2014},
  doi     = {10.1093/brain/awu043},
  pmid    = {24625697},
  url     = {https://doi.org/10.1093/brain/awu043}
}

@article{kunkle2025-41437928,
  author  = {Kunkle, Brian W. and Gomez, Lissette and Tosto, Giuseppe and Rodriguez, Omar Garcia and Slifer, Susan H. and Hamilton‐Nelson, Kara L. and Naj, Adam Christian and Kushch, Nicholas A. and others},
  title   = {{Novel sex‐specific candidate loci associated with Alzheimer disease identified through sex‐aware multi‐ancestry genome‐wide meta‐analysis}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_106407},
  pmid    = {41437928},
  url     = {https://doi.org/10.1002/alz70855_106407}
}

@article{oakley2006-17021169,
  author  = {Oakley, Holly D. and Cole, Sarah L. and Logan, Sreemathi and Maus, Erika and Shao, Pei and Craft, Jeffery and Guillozet-Bongaarts, Angela L. and Ohno, Masuo and others},
  title   = {{Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation}},
  journal = {Journal of Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.1202-06.2006},
  pmid    = {17021169},
  url     = {https://doi.org/10.1523/jneurosci.1202-06.2006}
}

@article{zhang2024-39363202,
  author  = {Zhang, X. X. and Wei, M. and Wang, H. R. and Hu, Y. Z. and Sun, H. M. and Jia, J. J.},
  title   = {{Mitochondrial dysfunction gene expression, DNA methylation, and inflammatory cytokines interaction activate Alzheimer's disease: a multi-omics Mendelian randomization study}},
  journal = {Journal of translational medicine},
  year    = {2024},
  doi     = {10.1186/s12967-024-05680-z},
  pmid    = {39363202},
  url     = {https://doi.org/10.1186/s12967-024-05680-z}
}

@article{o2025-39652363,
  author  = {Ö, İş and Min, Y. and Wang, X. and Oatman, SR. and Abraham Daniel, A. and Ertekin-Taner, N.},
  title   = {{Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects}},
  journal = {Glia},
  year    = {2025},
  doi     = {10.1002/glia.24652},
  pmid    = {39652363},
  url     = {https://doi.org/10.1002/glia.24652}
}

@article{hickman2008-18701698,
  author  = {Hickman, Suzanne E. and Allison, Elizabeth K. and El Khoury, Joseph B.},
  title   = {{Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice}},
  journal = {Journal of Neuroscience},
  year    = {2008},
  doi     = {10.1523/jneurosci.0616-08.2008},
  pmid    = {18701698},
  url     = {https://doi.org/10.1523/jneurosci.0616-08.2008}
}

@article{verghese2011-21349439,
  author  = {Verghese, Philip B. and Castellano, Joseph M. and Holtzman, David M.},
  title   = {{Apolipoprotein E in Alzheimer's disease and other neurological disorders}},
  journal = {The Lancet Neurology},
  year    = {2011},
  doi     = {10.1016/s1474-4422(10)70325-2},
  pmid    = {21349439},
  url     = {https://doi.org/10.1016/s1474-4422(10)70325-2}
}

@article{lu2026-42141098,
  author  = {Lu, L. and Pichet Binette, A. and Hristovska, I. and Janelidze, S. and Smets, B. and Cumplido-Mayoral, I. and Vasanthakumar, A. and Milkovich, B. and An, L. and Ossenkoppele, R. and Krish, V. and others},
  title   = {{Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease}},
  journal = {Nature Aging},
  year    = {2026},
  doi     = {10.1038/s43587-026-01123-0},
  pmid    = {42141098},
  url     = {https://doi.org/10.1038/s43587-026-01123-0}
}

@article{jack2014-24706010,
  author  = {Jack, C. R. and Wiste, H. J. and Knopman, D. S. and Vemuri, P. and Mielke, M. M. and Weigand, S. D. and Senjem, M. L. and Gunter, J. L. and others},
  title   = {{Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000386},
  pmid    = {24706010},
  url     = {https://doi.org/10.1212/wnl.0000000000000386}
}

@article{morris2022-35580594,
  author  = {Morris, J. C. and Weiner, M. and Xiong, C. and Beckett, L. and Coble, D. and Saito, N. and Aisen, P. S. and Allegri, R. and others},
  title   = {{Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awac181},
  pmid    = {35580594},
  url     = {https://doi.org/10.1093/brain/awac181}
}

@article{liu2013-23296339,
  author  = {Liu, C. C. and Kanekiyo, T. and Xu, H. and Bu, G.},
  title   = {{Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy}},
  journal = {Nature reviews. Neurology},
  year    = {2013},
  doi     = {10.1038/nrneurol.2012.263},
  pmid    = {23296339},
  url     = {https://doi.org/10.1038/nrneurol.2012.263}
}

@article{genin2011-21556001,
  author  = {Genin, E. and Hannequin, D. and Wallon, D. and Sleegers, K. and Hiltunen, M. and Combarros, O. and Bullido, M. J. and Engelborghs, S. and others},
  title   = {{APOE and Alzheimer disease: a major gene with semi-dominant inheritance}},
  journal = {Molecular psychiatry},
  year    = {2011},
  doi     = {10.1038/mp.2011.52},
  pmid    = {21556001},
  url     = {https://doi.org/10.1038/mp.2011.52}
}

@article{naj2010-20885792,
  author  = {Naj, A. C. and Beecham, G. W. and Martin, E. R. and Gallins, P. J. and Powell, E. H. and Konidari, I. and Whitehead, P. L. and Cai, G. and others},
  title   = {{Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities}},
  journal = {PLoS genetics},
  year    = {2010},
  doi     = {10.1371/journal.pgen.1001130},
  pmid    = {20885792},
  url     = {https://doi.org/10.1371/journal.pgen.1001130}
}

@article{brase2023-37085492,
  author  = {Brase, L. and You, S. F. and D'Oliveira Albanus, R. and Del-Aguila, J. L. and Dai, Y. and Novotny, B. C. and Soriano-Tarraga, C. and Dykstra, T. and others},
  title   = {{Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-37437-5},
  pmid    = {37085492},
  url     = {https://doi.org/10.1038/s41467-023-37437-5}
}

@article{lugli2015-26426747,
  author  = {Lugli, G. and Cohen, A. M. and Bennett, D. A. and Shah, R. C. and Fields, C. J. and Hernandez, A. G. and Smalheiser, N. R.},
  title   = {{Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers}},
  journal = {PloS one},
  year    = {2015},
  doi     = {10.1371/journal.pone.0139233},
  pmid    = {26426747},
  url     = {https://doi.org/10.1371/journal.pone.0139233}
}

@article{wu2021-33466861,
  author  = {Wu, L. and Han, Y. and Zheng, Z. and Peng, G. and Liu, P. and Yue, S. and Zhu, S. and Chen, J. and others},
  title   = {{Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Signals in Host-Microbe Interplay}},
  journal = {Nutrients},
  year    = {2021},
  doi     = {10.3390/nu13010228},
  pmid    = {33466861},
  url     = {https://doi.org/10.3390/nu13010228}
}

@article{ehehalt2003-12515826,
  author  = {Ehehalt, R. and Keller, P. and Haass, C. and Thiele, C. and Simons, K.},
  title   = {{Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts}},
  journal = {The Journal of cell biology},
  year    = {2003},
  doi     = {10.1083/jcb.200207113},
  pmid    = {12515826},
  url     = {https://doi.org/10.1083/jcb.200207113}
}

@article{areagomez2012-22892566,
  author  = {Area-Gomez, E. and Del Carmen Lara Castillo, M. and Tambini, M. D. and Guardia-Laguarta, C. and de Groof, A. J. and Madra, M. and Ikenouchi, J. and Umeda, M. and others},
  title   = {{Upregulated function of mitochondria-associated ER membranes in Alzheimer disease}},
  journal = {The EMBO journal},
  year    = {2012},
  doi     = {10.1038/emboj.2012.202},
  pmid    = {22892566},
  url     = {https://doi.org/10.1038/emboj.2012.202}
}

@article{town2008-18516051,
  author  = {Town, T. and Laouar, Y. and Pittenger, C. and Mori, T. and Szekely, C. A. and Tan, J. and Duman, R. S. and Flavell, R. A.},
  title   = {{Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology}},
  journal = {Nature medicine},
  year    = {2008},
  doi     = {10.1038/nm1781},
  pmid    = {18516051},
  url     = {https://doi.org/10.1038/nm1781}
}

@article{cisse2011-21113149,
  author  = {Cissé, M. and Halabisky, B. and Harris, J. and Devidze, N. and Dubal, D. B. and Sun, B. and Orr, A. and Lotz, G. and others},
  title   = {{Reversing EphB2 depletion rescues cognitive functions in Alzheimer model}},
  journal = {Nature},
  year    = {2011},
  doi     = {10.1038/nature09635},
  pmid    = {21113149},
  url     = {https://doi.org/10.1038/nature09635}
}

@article{harms2013-23588422,
  author  = {Harms, M. and Benitez, B. A. and Cairns, N. and Cooper, B. and Cooper, P. and Mayo, K. and Carrell, D. and Faber, K. and others},
  title   = {{C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/2013.jamaneurol.537},
  pmid    = {23588422},
  url     = {https://doi.org/10.1001/2013.jamaneurol.537}
}

@article{kunkle2017-28738127,
  author  = {Kunkle, B. W. and Vardarajan, B. N. and Naj, A. C. and Whitehead, P. L. and Rolati, S. and Slifer, S. and Carney, R. M. and Cuccaro, M. L. and others},
  title   = {{Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.1518},
  pmid    = {28738127},
  url     = {https://doi.org/10.1001/jamaneurol.2017.1518}
}

@article{ali2022-35617280,
  author  = {Ali, M. and Sung, Y. J. and Wang, F. and Fernández, M. V. and Morris, J. C. and Fagan, A. M. and Blennow, K. and Zetterberg, H. and others},
  title   = {{Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk}},
  journal = {PloS one},
  year    = {2022},
  doi     = {10.1371/journal.pone.0267298},
  pmid    = {35617280},
  url     = {https://doi.org/10.1371/journal.pone.0267298}
}

@article{mielke2011-21841258,
  author  = {Mielke, M. M. and Haughey, N. J. and Bandaru, V. V. and Weinberg, D. D. and Darby, E. and Zaidi, N. and Pavlik, V. and Doody, R. S. and others},
  title   = {{Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2011},
  doi     = {10.3233/jad-2011-110405},
  pmid    = {21841258},
  url     = {https://doi.org/10.3233/jad-2011-110405}
}

@article{tosun2024-38770829,
  author  = {Tosun, D. and Hausle, Z. and Iwaki, H. and Thropp, P. and Lamoureux, J. and Lee, E. B. and MacLeod, K. and McEvoy, S. and others},
  title   = {{A cross-sectional study of α-synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13858},
  pmid    = {38770829},
  url     = {https://doi.org/10.1002/alz.13858}
}

@article{katsumata2022-36191742,
  author  = {Katsumata, Y. and Shade, L. M. and Hohman, T. J. and Schneider, J. A. and Bennett, D. A. and Farfel, J. M. and {Alzheimer’s Disease Genetics Consortium} and Kukull, W. A. and others},
  title   = {{Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105880},
  pmid    = {36191742},
  url     = {https://doi.org/10.1016/j.nbd.2022.105880}
}

@article{jones2010-21085570,
  author  = {Jones, L. and Holmans, P. A. and Hamshere, M. L. and Harold, D. and Moskvina, V. and Ivanov, D. and Pocklington, A. and Abraham, R. and others},
  title   = {{Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0013950},
  pmid    = {21085570},
  url     = {https://doi.org/10.1371/journal.pone.0013950}
}

@article{roy2020-31917687,
  author  = {Roy, E. R. and Wang, B. and Wan, Y. W. and Chiu, G. and Cole, A. and Yin, Z. and Propson, N. E. and Xu, Y. and others},
  title   = {{Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2020},
  doi     = {10.1172/jci133737},
  pmid    = {31917687},
  url     = {https://doi.org/10.1172/jci133737}
}

@article{bartels2020-33004513,
  author  = {Bartels, T. and De Schepper, S. and Hong, S.},
  title   = {{Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases}},
  journal = {Science (New York, N.Y.)},
  year    = {2020},
  doi     = {10.1126/science.abb8587},
  pmid    = {33004513},
  url     = {https://doi.org/10.1126/science.abb8587}
}

@article{mafe2025-40361641,
  author  = {Mafe, Alice Njolke and Büsselberg, Dietrich},
  title   = {{Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration}},
  journal = {Foods},
  year    = {2025},
  doi     = {10.3390/foods14091559},
  pmid    = {40361641},
  url     = {https://doi.org/10.3390/foods14091559}
}

@article{insel2021-34297074,
  author  = {Insel, P. S. and Mohlenhoff, B. S. and Neylan, T. C. and Krystal, A. D. and Mackin, R. S.},
  title   = {{Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults}},
  journal = {JAMA network open},
  year    = {2021},
  doi     = {10.1001/jamanetworkopen.2021.17573},
  pmid    = {34297074},
  url     = {https://doi.org/10.1001/jamanetworkopen.2021.17573}
}

@article{deane2008-19033669,
  author  = {Deane, R. and Sagare, A. and Hamm, K. and Parisi, M. and Lane, S. and Finn, M. B. and Holtzman, D. M. and Zlokovic, B. V.},
  title   = {{apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci36663},
  pmid    = {19033669},
  url     = {https://doi.org/10.1172/jci36663}
}

@article{lim2005-15788759,
  author  = {Lim, G. P. and Calon, F. and Morihara, T. and Yang, F. and Teter, B. and Ubeda, O. and Salem, N. and Frautschy, S. A. and others},
  title   = {{A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.4225-04.2005},
  pmid    = {15788759},
  url     = {https://doi.org/10.1523/jneurosci.4225-04.2005}
}

@article{serranopozo2015-25623662,
  author  = {Serrano-Pozo, A. and Qian, J. and Monsell, S. E. and Betensky, R. A. and Hyman, B. T.},
  title   = {{APOEε2 is associated with milder clinical and pathological Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24369},
  pmid    = {25623662},
  url     = {https://doi.org/10.1002/ana.24369}
}

@article{vemuri2010-20373342,
  author  = {Vemuri, P. and Wiste, H. J. and Weigand, S. D. and Knopman, D. S. and Shaw, L. M. and Trojanowski, J. Q. and Aisen, P. S. and Weiner, M. and others},
  title   = {{Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.21953},
  pmid    = {20373342},
  url     = {https://doi.org/10.1002/ana.21953}
}

@article{voevodskaya2016-27164711,
  author  = {Voevodskaya, O. and Sundgren, P. C. and Strandberg, O. and Zetterberg, H. and Minthon, L. and Blennow, K. and Wahlund, L. O. and Westman, E. and others},
  title   = {{Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000002672},
  pmid    = {27164711},
  url     = {https://doi.org/10.1212/wnl.0000000000002672}
}

@article{nordestgaard2022-34613338,
  author  = {Nordestgaard, L. T. and Christoffersen, M. and Lauridsen, B. K. and Afzal, S. and Nordestgaard, B. G. and Frikke-Schmidt, R. and Tybjærg-Hansen, A.},
  title   = {{Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population}},
  journal = {JAMA cardiology},
  year    = {2022},
  doi     = {10.1001/jamacardio.2021.3728},
  pmid    = {34613338},
  url     = {https://doi.org/10.1001/jamacardio.2021.3728}
}

@article{cacciottolo2017-28140404,
  author  = {Cacciottolo, M. and Wang, X. and Driscoll, I. and Woodward, N. and Saffari, A. and Reyes, J. and Serre, M. L. and Vizuete, W. and others},
  title   = {{Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models}},
  journal = {Translational psychiatry},
  year    = {2017},
  doi     = {10.1038/tp.2016.280},
  pmid    = {28140404},
  url     = {https://doi.org/10.1038/tp.2016.280}
}

@article{bloom2014-24493463,
  author  = {Bloom, G. S.},
  title   = {{Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.5847},
  pmid    = {24493463},
  url     = {https://doi.org/10.1001/jamaneurol.2013.5847}
}

@article{verret2012-22541439,
  author  = {Verret, L. and Mann, E. O. and Hang, G. B. and Barth, A. M. and Cobos, I. and Ho, K. and Devidze, N. and Masliah, E. and others},
  title   = {{Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model}},
  journal = {Cell},
  year    = {2012},
  doi     = {10.1016/j.cell.2012.02.046},
  pmid    = {22541439},
  url     = {https://doi.org/10.1016/j.cell.2012.02.046}
}

@article{thinakaran2008-18650430,
  author  = {Thinakaran, G. and Koo, E. H.},
  title   = {{Amyloid precursor protein trafficking, processing, and function}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.r800019200},
  pmid    = {18650430},
  url     = {https://doi.org/10.1074/jbc.r800019200}
}

@article{chavezgutierrez2012-22505025,
  author  = {Chávez-Gutiérrez, L. and Bammens, L. and Benilova, I. and Vandersteen, A. and Benurwar, M. and Borgers, M. and Lismont, S. and Zhou, L. and others},
  title   = {{The mechanism of γ-Secretase dysfunction in familial Alzheimer disease}},
  journal = {The EMBO journal},
  year    = {2012},
  doi     = {10.1038/emboj.2012.79},
  pmid    = {22505025},
  url     = {https://doi.org/10.1038/emboj.2012.79}
}

@article{suarezcalvet2016-27974666,
  author  = {Suárez-Calvet, M. and MÁ, Araque Caballero and Kleinberger, G. and Bateman, R. J. and Fagan, A. M. and Morris, J. C. and Levin, J. and Danek, A. and others},
  title   = {{Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury}},
  journal = {Science translational medicine},
  year    = {2016},
  doi     = {10.1126/scitranslmed.aag1767},
  pmid    = {27974666},
  url     = {https://doi.org/10.1126/scitranslmed.aag1767}
}

@article{ma2018-30239611,
  author  = {MÁ, Araque Caballero and Suárez-Calvet, M. and Duering, M. and Franzmeier, N. and Benzinger, T. and Fagan, A. M. and Bateman, R. J. and Jack, C. R. and others},
  title   = {{White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awy229},
  pmid    = {30239611},
  url     = {https://doi.org/10.1093/brain/awy229}
}

@article{patel2019-30924900,
  author  = {Patel, D. and Mez, J. and Vardarajan, B. N. and Staley, L. and Chung, J. and Zhang, X. and Farrell, J. J. and Rynkiewicz, M. J. and others},
  title   = {{Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry}},
  journal = {JAMA network open},
  year    = {2019},
  doi     = {10.1001/jamanetworkopen.2019.1350},
  pmid    = {30924900},
  url     = {https://doi.org/10.1001/jamanetworkopen.2019.1350}
}

@article{hu2021-33461566,
  author  = {Hu, Y. and Sun, J. Y. and Zhang, Y. and Zhang, H. and Gao, S. and Wang, T. and Han, Z. and Wang, L. and others},
  title   = {{rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues}},
  journal = {BMC medicine},
  year    = {2021},
  doi     = {10.1186/s12916-020-01883-5},
  pmid    = {33461566},
  url     = {https://doi.org/10.1186/s12916-020-01883-5}
}

@article{weise2018-30101060,
  author  = {Weise, C. M. and Chen, K. and Chen, Y. and Kuang, X. and Savage, C. R. and Reiman, E. M. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Left lateralized cerebral glucose metabolism declines in amyloid-β positive persons with mild cognitive impairment}},
  journal = {NeuroImage. Clinical},
  year    = {2018},
  doi     = {10.1016/j.nicl.2018.07.016},
  pmid    = {30101060},
  url     = {https://doi.org/10.1016/j.nicl.2018.07.016}
}

@article{greenberg2020-31827267,
  author  = {Greenberg, S. M. and Bacskai, B. J. and Hernandez-Guillamon, M. and Pruzin, J. and Sperling, R. and van Veluw, S. J.},
  title   = {{Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways}},
  journal = {Nature reviews. Neurology},
  year    = {2020},
  doi     = {10.1038/s41582-019-0281-2},
  pmid    = {31827267},
  url     = {https://doi.org/10.1038/s41582-019-0281-2}
}

@article{jayadev2010-20375137,
  author  = {Jayadev, S. and Leverenz, J. B. and Steinbart, E. and Stahl, J. and Klunk, W. and Yu, C. E. and Bird, T. D.},
  title   = {{Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2}},
  journal = {Brain : a journal of neurology},
  year    = {2010},
  doi     = {10.1093/brain/awq033},
  pmid    = {20375137},
  url     = {https://doi.org/10.1093/brain/awq033}
}

@article{minett2016-27256292,
  author  = {Minett, T. and Classey, J. and Matthews, F. E. and Fahrenhold, M. and Taga, M. and Brayne, C. and Ince, P. G. and Nicoll, J. A. and others},
  title   = {{Microglial immunophenotype in dementia with Alzheimer's pathology}},
  journal = {Journal of neuroinflammation},
  year    = {2016},
  doi     = {10.1186/s12974-016-0601-z},
  pmid    = {27256292},
  url     = {https://doi.org/10.1186/s12974-016-0601-z}
}

@article{tarawneh2026-42098850,
  author  = {Tarawneh, Rawan M. and Moulder, Krista L. and Topouza, Danai Georgia and Kar, Amrita Ghosh and Qian, Heng and Pankratz, V. Shane and Timsina, Jigyasha and Franklin, Erin E. and others},
  title   = {{Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-02043-2},
  pmid    = {42098850},
  url     = {https://doi.org/10.1186/s13195-026-02043-2}
}

@article{fandos2026-41513583,
  author  = {Fandos, Noelia and Pascual‐Lucas, María and Sarasa, Leticia and Terencio, Jose Vicente and Sáez, Mª Eugenia and Tartari, Juan Pablo and Sanabria, Ángela and Sotolongo‐Grau, Óscar and others},
  title   = {{Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer’s disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1016/j.tjpad.2025.100465},
  pmid    = {41513583},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100465}
}

@article{simard2006-16476660,
  author  = {Simard, Alain R. and Soulet, Denis and Gowing, Genevíève and Julien, Jean-Pierre and Rivest, Serge},
  title   = {{Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2006},
  doi     = {10.1016/j.neuron.2006.01.022},
  pmid    = {16476660},
  url     = {https://doi.org/10.1016/j.neuron.2006.01.022}
}

@article{yassine2016-27532692,
  author  = {Yassine, H. N. and Feng, Q. and Azizkhanian, I. and Rawat, V. and Castor, K. and Fonteh, A. N. and Harrington, M. G. and Zheng, L. and others},
  title   = {{Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis}},
  journal = {JAMA neurology},
  year    = {2016},
  doi     = {10.1001/jamaneurol.2016.1924},
  pmid    = {27532692},
  url     = {https://doi.org/10.1001/jamaneurol.2016.1924}
}

@article{strittmatter1993-8367470,
  author  = {Strittmatter, W. J. and Weisgraber, K. H. and Huang, D. Y. and Dong, L. M. and Salvesen, G. S. and Pericak-Vance, M. and Schmechel, D. and Saunders, A. M. and others},
  title   = {{Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.17.8098},
  pmid    = {8367470},
  url     = {https://doi.org/10.1073/pnas.90.17.8098}
}

@article{yin2020-32457210,
  author  = {Yin, J. and Reiman, E. M. and Beach, T. G. and Serrano, G. E. and Sabbagh, M. N. and Nielsen, M. and Caselli, R. J. and Shi, J.},
  title   = {{Effect of ApoE isoforms on mitochondria in Alzheimer disease}},
  journal = {Neurology},
  year    = {2020},
  doi     = {10.1212/wnl.0000000000009582},
  pmid    = {32457210},
  url     = {https://doi.org/10.1212/wnl.0000000000009582}
}

@article{cukier2016-27231719,
  author  = {Cukier, H. N. and Kunkle, B. W. and Vardarajan, B. N. and Rolati, S. and Hamilton-Nelson, K. L. and Kohli, M. A. and Whitehead, P. L. and Dombroski, B. A. and others},
  title   = {{ABCA7 frameshift deletion associated with Alzheimer disease in African Americans}},
  journal = {Neurology. Genetics},
  year    = {2016},
  doi     = {10.1212/nxg.0000000000000079},
  pmid    = {27231719},
  url     = {https://doi.org/10.1212/nxg.0000000000000079}
}

@article{allen2012-22494505,
  author  = {Allen, M. and Zou, F. and Chai, H. S. and Younkin, C. S. and Miles, R. and Nair, A. A. and Crook, J. E. and Pankratz, V. S. and others},
  title   = {{Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications}},
  journal = {Molecular neurodegeneration},
  year    = {2012},
  doi     = {10.1186/1750-1326-7-13},
  pmid    = {22494505},
  url     = {https://doi.org/10.1186/1750-1326-7-13}
}

@article{barral2012-22539578,
  author  = {Barral, S. and Bird, T. and Goate, A. and Farlow, M. R. and Diaz-Arrastia, R. and Bennett, D. A. and Graff-Radford, N. and Boeve, B. F. and others},
  title   = {{Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e3182553c48},
  pmid    = {22539578},
  url     = {https://doi.org/10.1212/wnl.0b013e3182553c48}
}

@article{kim2020-32690787,
  author  = {Kim, J. W. and Byun, M. S. and Lee, J. H. and Yi, D. and Jeon, S. Y. and Sohn, B. K. and Lee, J. Y. and Shin, S. A. and others},
  title   = {{Serum albumin and beta-amyloid deposition in the human brain}},
  journal = {Neurology},
  year    = {2020},
  doi     = {10.1212/wnl.0000000000010005},
  pmid    = {32690787},
  url     = {https://doi.org/10.1212/wnl.0000000000010005}
}

@article{vilaplana2020-32291295,
  author  = {Vilaplana, E. and Rodriguez-Vieitez, E. and Ferreira, D. and Montal, V. and Almkvist, O. and Wall, A. and Lleó, A. and Westman, E. and others},
  title   = {{Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease}},
  journal = {Neurology},
  year    = {2020},
  doi     = {10.1212/wnl.0000000000009405},
  pmid    = {32291295},
  url     = {https://doi.org/10.1212/wnl.0000000000009405}
}

@article{lemere1996-8837617,
  author  = {Lemere, C. A. and Lopera, F. and Kosik, K. S. and Lendon, C. L. and Ossa, J. and Saido, T. C. and Yamaguchi, H. and Ruiz, A. and others},
  title   = {{The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology}},
  journal = {Nature medicine},
  year    = {1996},
  doi     = {10.1038/nm1096-1146},
  pmid    = {8837617},
  url     = {https://doi.org/10.1038/nm1096-1146}
}

@article{podlesniy2013-23794434,
  author  = {Podlesniy, P. and Figueiro-Silva, J. and Llado, A. and Antonell, A. and Sanchez-Valle, R. and Alcolea, D. and Lleo, A. and Molinuevo, J. L. and others},
  title   = {{Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23955},
  pmid    = {23794434},
  url     = {https://doi.org/10.1002/ana.23955}
}

@article{efthymiou2017-28549481,
  author  = {Efthymiou, A. G. and Goate, A. M.},
  title   = {{Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0184-x},
  pmid    = {28549481},
  url     = {https://doi.org/10.1186/s13024-017-0184-x}
}

@article{sleegers2006-16921174,
  author  = {Sleegers, K. and Brouwers, N. and Gijselinck, I. and Theuns, J. and Goossens, D. and Wauters, J. and Del-Favero, J. and Cruts, M. and others},
  title   = {{APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy}},
  journal = {Brain : a journal of neurology},
  year    = {2006},
  doi     = {10.1093/brain/awl203},
  pmid    = {16921174},
  url     = {https://doi.org/10.1093/brain/awl203}
}

@article{wingo2012-21911656,
  author  = {Wingo, T. S. and Lah, J. J. and Levey, A. I. and Cutler, D. J.},
  title   = {{Autosomal recessive causes likely in early-onset Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2012},
  doi     = {10.1001/archneurol.2011.221},
  pmid    = {21911656},
  url     = {https://doi.org/10.1001/archneurol.2011.221}
}

@article{yang2017-28053038,
  author  = {Yang, T. and Li, S. and Xu, H. and Walsh, D. M. and Selkoe, D. J.},
  title   = {{Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.1698-16.2016},
  pmid    = {28053038},
  url     = {https://doi.org/10.1523/jneurosci.1698-16.2016}
}

@article{akgun2025-41434771,
  author  = {Akgün, Bilçağ and Xu, Wanying and Hamilton‐Nelson, Kara L. and Nasciben, Luciana Bertholim and Scott, Kyle M. and Adams, Larry Deon and Sanchez, Jose J. and Valladares, Glenies S and others},
  title   = {{Significant association between SCN8A and Alzheimer disease in Puerto Ricans}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_098248},
  pmid    = {41434771},
  url     = {https://doi.org/10.1002/alz70855_098248}
}

@article{planalp2025-40461705,
  author  = {Planalp, Elizabeth M. and Langhough, Rebecca E. and Jonaitis, Erin McMullen and Van Hulle, Carol Ann and Wilson, Rachael E. and Kollmorgen, Gwendlyn and Quijano‐Rubio, Clara and Okonkwo, Ozioma C. and others},
  title   = {{Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer’s disease cohort}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-04319-3},
  pmid    = {40461705},
  url     = {https://doi.org/10.1038/s41598-025-04319-3}
}

@article{ebbert2016-26449541,
  author  = {Ebbert, M. T. W. and Boehme, K. L. and Wadsworth, M. E. and Staley, L. A. and {Alzheimer's Disease Neuroimaging Initiative} and {Alzheimer's Disease Genetics Consortium} and Mukherjee, S. and Crane, P. K. and others},
  title   = {{Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2015.08.163},
  pmid    = {26449541},
  url     = {https://doi.org/10.1016/j.jalz.2015.08.163}
}

@article{reiman2009-19346482,
  author  = {Reiman, Eric M. and Chen, Kewei and Liu, Xiaofen and Bandy, Daniel J. and Yu, Meixiang and Lee, Wendy and Ayutyanont, Napatkamon and Keppler, Jennifer S. and Reeder, Stephanie and Langbaum, Jessica B. S. and Alexander, Gene E. and Klunk, William E. and Mathis, Chester A. and Price, Julie C. and Aizenstein, Howard Jay and DeKosky, Steven T. and Caselli, Richard J.},
  title   = {{Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {2009},
  doi     = {10.1073/pnas.0900345106},
  pmid    = {19346482},
  url     = {https://doi.org/10.1073/pnas.0900345106}
}

@article{bu2009-19339974,
  author  = {Bu, Guojun},
  title   = {{Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy}},
  journal = {Nature reviews. Neuroscience},
  year    = {2009},
  doi     = {10.1038/nrn2620},
  pmid    = {19339974},
  url     = {https://doi.org/10.1038/nrn2620}
}

@article{melzer2019-31105633,
  author  = {Melzer, T. R. and Stark, M. R. and Keenan, R. J. and Myall, D. J. and MacAskill, M. R. and Pitcher, T. L. and Livingston, L. and Grenfell, S. and others},
  title   = {{Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease}},
  journal = {Frontiers in neurology},
  year    = {2019},
  doi     = {10.3389/fneur.2019.00391},
  pmid    = {31105633},
  url     = {https://doi.org/10.3389/fneur.2019.00391}
}

@article{tong2024-39444005,
  author  = {Tong, T. and Zhu, C. and Farrell, J. J. and Khurshid, Z. and {Alzheimer’s Disease Sequencing Project} and {Alzheimer’s Disease Neuroimaging Initiative} and Martin, E. R. and Pericak-Vance, M. A. and others},
  title   = {{Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01601-w},
  pmid    = {39444005},
  url     = {https://doi.org/10.1186/s13195-024-01601-w}
}

@article{biechele2022-34016733,
  author  = {Biechele, G. and Monasor, L. S. and Wind, K. and Blume, T. and Parhizkar, S. and Arzberger, T. and Sacher, C. and Beyer, L. and others},
  title   = {{Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2022},
  doi     = {10.2967/jnumed.120.261858},
  pmid    = {34016733},
  url     = {https://doi.org/10.2967/jnumed.120.261858}
}

@article{yamazaki2019-31367008,
  author  = {Yamazaki, Y. and Zhao, N. and Caulfield, T. R. and Liu, C. C. and Bu, G.},
  title   = {{Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies}},
  journal = {Nature reviews. Neurology},
  year    = {2019},
  doi     = {10.1038/s41582-019-0228-7},
  pmid    = {31367008},
  url     = {https://doi.org/10.1038/s41582-019-0228-7}
}

@article{schmechel1993-8415756,
  author  = {Schmechel, D. E. and Saunders, A. M. and Strittmatter, W. J. and Crain, B. J. and Hulette, C. M. and Joo, S. H. and Pericak-Vance, M. A. and Goldgaber, D. and others},
  title   = {{Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.20.9649},
  pmid    = {8415756},
  url     = {https://doi.org/10.1073/pnas.90.20.9649}
}

@article{qin2009-19273754,
  author  = {Qin, W. and Haroutunian, V. and Katsel, P. and Cardozo, C. P. and Ho, L. and Buxbaum, J. D. and Pasinetti, G. M.},
  title   = {{PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2008.588},
  pmid    = {19273754},
  url     = {https://doi.org/10.1001/archneurol.2008.588}
}

@article{chen2021-33176118,
  author  = {Chen, Y. and Strickland, M. R. and Soranno, A. and Holtzman, D. M.},
  title   = {{Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2020.10.008},
  pmid    = {33176118},
  url     = {https://doi.org/10.1016/j.neuron.2020.10.008}
}

@article{irie2008-18195144,
  author  = {Irie, F. and Fitzpatrick, A. L. and Lopez, O. L. and Kuller, L. H. and Peila, R. and Newman, A. B. and Launer, L. J.},
  title   = {{Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneurol.2007.29},
  pmid    = {18195144},
  url     = {https://doi.org/10.1001/archneurol.2007.29}
}

@article{jun2017-28183528,
  author  = {Jun, G. R. and Chung, J. and Mez, J. and Barber, R. and Beecham, G. W. and Bennett, D. A. and Buxbaum, J. D. and Byrd, G. S. and others},
  title   = {{Transethnic genome-wide scan identifies novel Alzheimer's disease loci}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.12.012},
  pmid    = {28183528},
  url     = {https://doi.org/10.1016/j.jalz.2016.12.012}
}

@article{liao2018-29600961,
  author  = {Liao, F. and Li, A. and Xiong, M. and Bien-Ly, N. and Jiang, H. and Zhang, Y. and Finn, M. B. and Hoyle, R. and others},
  title   = {{Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation}},
  journal = {The Journal of clinical investigation},
  year    = {2018},
  doi     = {10.1172/jci96429},
  pmid    = {29600961},
  url     = {https://doi.org/10.1172/jci96429}
}

@article{hendrie2014-24565289,
  author  = {Hendrie, H. C. and Murrell, J. and Baiyewu, O. and Lane, K. A. and Purnell, C. and Ogunniyi, A. and Unverzagt, F. W. and Hall, K. and others},
  title   = {{APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba}},
  journal = {International psychogeriatrics},
  year    = {2014},
  doi     = {10.1017/s1041610214000167},
  pmid    = {24565289},
  url     = {https://doi.org/10.1017/s1041610214000167}
}

@article{slattery2017-28578156,
  author  = {Slattery, C. F. and Zhang, J. and Paterson, R. W. and Foulkes, A. J. M. and Carton, A. and Macpherson, K. and Mancini, L. and Thomas, D. L. and others},
  title   = {{ApoE influences regional white-matter axonal density loss in Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.04.021},
  pmid    = {28578156},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.04.021}
}

@article{cruchaga2011-21825236,
  author  = {Cruchaga, C. and Nowotny, P. and Kauwe, J. S. and Ridge, P. G. and Mayo, K. and Bertelsen, S. and Hinrichs, A. and Fagan, A. M. and others},
  title   = {{Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2011.155},
  pmid    = {21825236},
  url     = {https://doi.org/10.1001/archneurol.2011.155}
}

@article{bennett2009-19398704,
  author  = {Bennett, D. A. and De Jager, P. L. and Leurgans, S. E. and Schneider, J. A.},
  title   = {{Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181a2e87d},
  pmid    = {19398704},
  url     = {https://doi.org/10.1212/wnl.0b013e3181a2e87d}
}

@article{rentz2011-21689670,
  author  = {Rentz, D. M. and Amariglio, R. E. and Becker, J. A. and Frey, M. and Olson, L. E. and Frishe, K. and Carmasin, J. and Maye, J. E. and others},
  title   = {{Face-name associative memory performance is related to amyloid burden in normal elderly}},
  journal = {Neuropsychologia},
  year    = {2011},
  doi     = {10.1016/j.neuropsychologia.2011.06.006},
  pmid    = {21689670},
  url     = {https://doi.org/10.1016/j.neuropsychologia.2011.06.006}
}

@article{borchelt1997-9354339,
  author  = {Borchelt, D. R. and Ratovitski, T. and van Lare, J. and Lee, M. K. and Gonzales, V. and Jenkins, N. A. and Copeland, N. G. and Price, D. L. and others},
  title   = {{Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins}},
  journal = {Neuron},
  year    = {1997},
  doi     = {10.1016/s0896-6273(00)80974-5},
  pmid    = {9354339},
  url     = {https://doi.org/10.1016/s0896-6273(00)80974-5}
}

@article{leissring2003-14687544,
  author  = {Leissring, M. A. and Farris, W. and Chang, A. Y. and Walsh, D. M. and Wu, X. and Sun, X. and Frosch, M. P. and Selkoe, D. J.},
  title   = {{Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00787-6},
  pmid    = {14687544},
  url     = {https://doi.org/10.1016/s0896-6273(03)00787-6}
}

@article{roberts1994-8163989,
  author  = {Roberts, G. W. and Gentleman, S. M. and Lynch, A. and Murray, L. and Landon, M. and Graham, D. I.},
  title   = {{Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {1994},
  doi     = {10.1136/jnnp.57.4.419},
  pmid    = {8163989},
  url     = {https://doi.org/10.1136/jnnp.57.4.419}
}

@article{gourmaud2020-31834353,
  author  = {Gourmaud, S. and Shou, H. and Irwin, D. J. and Sansalone, K. and Jacobs, L. M. and Lucas, T. H. and Marsh, E. D. and Davis, K. A. and others},
  title   = {{Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awz381},
  pmid    = {31834353},
  url     = {https://doi.org/10.1093/brain/awz381}
}

@article{zhao2020-32199103,
  author  = {Zhao, N. and Ren, Y. and Yamazaki, Y. and Qiao, W. and Li, F. and Felton, L. M. and Mahmoudiandehkordi, S. and Kueider-Paisley, A. and others},
  title   = {{Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2020.02.034},
  pmid    = {32199103},
  url     = {https://doi.org/10.1016/j.neuron.2020.02.034}
}

@article{kianishabestari2022-35705056,
  author  = {Kiani Shabestari, S. and Morabito, S. and Danhash, E. P. and McQuade, A. and Sanchez, JR. and Miyoshi, E. and Chadarevian, J. P. and Claes, C. and others},
  title   = {{Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice}},
  journal = {Cell reports},
  year    = {2022},
  doi     = {10.1016/j.celrep.2022.110961},
  pmid    = {35705056},
  url     = {https://doi.org/10.1016/j.celrep.2022.110961}
}

@article{panitch2021-34480088,
  author  = {Panitch, R. and Hu, J. and Chung, J. and Zhu, C. and Meng, G. and Xia, W. and Bennett, D. A. and Lunetta, K. L. and others},
  title   = {{Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease}},
  journal = {Molecular psychiatry},
  year    = {2021},
  doi     = {10.1038/s41380-021-01266-z},
  pmid    = {34480088},
  url     = {https://doi.org/10.1038/s41380-021-01266-z}
}

@article{dauvilliers2014-24966833,
  author  = {Dauvilliers, Y. A. and Lehmann, S. and Jaussent, I. and Gabelle, A.},
  title   = {{Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy}},
  journal = {Frontiers in aging neuroscience},
  year    = {2014},
  doi     = {10.3389/fnagi.2014.00119},
  pmid    = {24966833},
  url     = {https://doi.org/10.3389/fnagi.2014.00119}
}

@article{sando2008-18416843,
  author  = {Sando, S. B. and Melquist, S. and Cannon, A. and Hutton, M. L. and Sletvold, O. and Saltvedt, I. and White, L. R. and Lydersen, S. and others},
  title   = {{APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway}},
  journal = {BMC neurology},
  year    = {2008},
  doi     = {10.1186/1471-2377-8-9},
  pmid    = {18416843},
  url     = {https://doi.org/10.1186/1471-2377-8-9}
}

@article{holland2013-23828104,
  author  = {Holland, D. and Desikan, R. S. and Dale, A. M. and McEvoy, L. K. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Higher rates of decline for women and apolipoprotein E epsilon4 carriers}},
  journal = {AJNR. American journal of neuroradiology},
  year    = {2013},
  doi     = {10.3174/ajnr.a3601},
  pmid    = {23828104},
  url     = {https://doi.org/10.3174/ajnr.a3601}
}

@article{bao2025-40221240,
  author  = {Bao, Cuiping and Luo, Hongbin and Wang, Jiao and Liu, Xuehuan and Li, Yiming and Yang, Jun and Chen, Chong and Yang, Rongrong and others},
  title   = {{Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer's disease: A DTI-ALPS study}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100156},
  pmid    = {40221240},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100156}
}

@article{hixson1990-2341813,
  author  = {Hixson, James E. and Vernier, D.T.},
  title   = {{Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI}},
  journal = {Journal of Lipid Research},
  year    = {1990},
  doi     = {10.1016/s0022-2275(20)43176-1},
  pmid    = {2341813},
  url     = {https://doi.org/10.1016/s0022-2275(20)43176-1}
}

@article{drenth2017-28558966,
  author  = {Drenth, H. and Zuidema, S. U. and Krijnen, W. P. and Bautmans, I. and van der Schans, C. and Hobbelen, H.},
  title   = {{Advanced Glycation End-Products Are Associated With the Presence and Severity of Paratonia in Early Stage Alzheimer Disease}},
  journal = {Journal of the American Medical Directors Association},
  year    = {2017},
  doi     = {10.1016/j.jamda.2017.04.004},
  pmid    = {28558966},
  url     = {https://doi.org/10.1016/j.jamda.2017.04.004}
}

@article{li2023-37260021,
  author  = {Li, D. and Farrell, J. J. and Mez, J. and Martin, E. R. and Bush, W. S. and Ruiz, A. and Boada, M. and de Rojas, I. and Mayeux, R. and Haines, J. L. and Vance, M. A. P. and Wang, L. S. and others},
  title   = {{Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews}},
  journal = {Alzheimer's \& Dementia},
  year    = {2023},
  doi     = {10.1002/alz.13117},
  pmid    = {37260021},
  url     = {https://doi.org/10.1002/alz.13117}
}

@article{hung2024-38527856,
  author  = {Hung, C. and Fertan, E. and Livesey, F. J. and Klenerman, D. and Patani, R.},
  title   = {{APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease}},
  journal = {Brain},
  year    = {2024},
  doi     = {10.1093/brain/awae092},
  pmid    = {38527856},
  url     = {https://doi.org/10.1093/brain/awae092}
}

@article{mahan2022-35109920,
  author  = {Mahan, T. E. and Wang, C. and Bao, X. and Choudhury, A. and Ulrich, J. D. and Holtzman, D. M.},
  title   = {{Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00516-0},
  pmid    = {35109920},
  url     = {https://doi.org/10.1186/s13024-022-00516-0}
}

@article{guillotsestier2015-25619654,
  author  = {Guillot-Sestier, M. V. and Doty, K. R. and Gate, D. and Rodriguez, J. and Leung, B. P. and Rezai-Zadeh, K. and Town, T.},
  title   = {{Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology}},
  journal = {Neuron},
  year    = {2015},
  doi     = {10.1016/j.neuron.2014.12.068},
  pmid    = {25619654},
  url     = {https://doi.org/10.1016/j.neuron.2014.12.068}
}

@article{sierksma2020-31951107,
  author  = {Sierksma, A. and Lu, A. and Mancuso, R. and Fattorelli, N. and Thrupp, N. and Salta, E. and Zoco, J. and Blum, D. and others},
  title   = {{Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology}},
  journal = {EMBO molecular medicine},
  year    = {2020},
  doi     = {10.15252/emmm.201910606},
  pmid    = {31951107},
  url     = {https://doi.org/10.15252/emmm.201910606}
}

@article{huynh2017-29216448,
  author  = {Huynh, T. V. and Liao, F. and Francis, C. M. and Robinson, G. O. and Serrano, JR. and Jiang, H. and Roh, J. and Finn, M. B. and others},
  title   = {{Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.11.014},
  pmid    = {29216448},
  url     = {https://doi.org/10.1016/j.neuron.2017.11.014}
}

@article{blumenfeld2024-38191720,
  author  = {Blumenfeld, J. and Yip, O. and Kim, M. J. and Huang, Y.},
  title   = {{Cell type-specific roles of APOE4 in Alzheimer disease}},
  journal = {Nature reviews. Neuroscience},
  year    = {2024},
  doi     = {10.1038/s41583-023-00776-9},
  pmid    = {38191720},
  url     = {https://doi.org/10.1038/s41583-023-00776-9}
}

@article{sabuncu2012-22169231,
  author  = {Sabuncu, M. R. and Buckner, R. L. and Smoller, J. W. and Lee, P. H. and Fischl, B. and Sperling, R. A. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects}},
  journal = {Cerebral cortex (New York, N.Y. : 1991)},
  year    = {2012},
  doi     = {10.1093/cercor/bhr348},
  pmid    = {22169231},
  url     = {https://doi.org/10.1093/cercor/bhr348}
}

@article{kovacs2016-27016065,
  author  = {Kovacs, G. G. and Lutz, M. I. and Ricken, G. and Ströbel, T. and Höftberger, R. and Preusser, M. and Regelsberger, G. and Hönigschnabl, S. and others},
  title   = {{Dura mater is a potential source of Aβ seeds}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-016-1565-x},
  pmid    = {27016065},
  url     = {https://doi.org/10.1007/s00401-016-1565-x}
}

@article{lowe2014-24793183,
  author  = {Lowe, V. J. and Weigand, S. D. and Senjem, M. L. and Vemuri, P. and Jordan, L. and Kantarci, K. and Boeve, B. and Jack, C. R. and others},
  title   = {{Association of hypometabolism and amyloid levels in aging, normal subjects}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000467},
  pmid    = {24793183},
  url     = {https://doi.org/10.1212/wnl.0000000000000467}
}

@article{verdile2015-26693205,
  author  = {Verdile, G. and Keane, K. N. and Cruzat, V. F. and Medic, S. and Sabale, M. and Rowles, J. and Wijesekara, N. and Martins, R. N. and others},
  title   = {{Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease}},
  journal = {Mediators of inflammation},
  year    = {2015},
  doi     = {10.1155/2015/105828},
  pmid    = {26693205},
  url     = {https://doi.org/10.1155/2015/105828}
}

@article{goetzl2016-27511944,
  author  = {Goetzl, E. J. and Mustapic, M. and Kapogiannis, D. and Eitan, E. and Lobach, IV. and Goetzl, L. and Schwartz, J. B. and Miller, B. L.},
  title   = {{Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2016},
  doi     = {10.1096/fj.201600756r},
  pmid    = {27511944},
  url     = {https://doi.org/10.1096/fj.201600756r}
}

@article{bai2013-24023061,
  author  = {Bai, B. and Hales, C. M. and Chen, P. C. and Gozal, Y. and Dammer, E. B. and Fritz, J. J. and Wang, X. and Xia, Q. and others},
  title   = {{U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2013},
  doi     = {10.1073/pnas.1310249110},
  pmid    = {24023061},
  url     = {https://doi.org/10.1073/pnas.1310249110}
}

@article{wang2008-18234899,
  author  = {Wang, W. X. and Rajeev, B. W. and Stromberg, A. J. and Ren, N. and Tang, G. and Huang, Q. and Rigoutsos, I. and Nelson, P. T.},
  title   = {{The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2008},
  doi     = {10.1523/jneurosci.5065-07.2008},
  pmid    = {18234899},
  url     = {https://doi.org/10.1523/jneurosci.5065-07.2008}
}

@article{weissman2007-17704129,
  author  = {Weissman, L. and Jo, D. G. and Sørensen, M. M. and de Souza-Pinto, N. C. and Markesbery, W. R. and Mattson, M. P. and Bohr, V. A.},
  title   = {{Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment}},
  journal = {Nucleic acids research},
  year    = {2007},
  doi     = {10.1093/nar/gkm605},
  pmid    = {17704129},
  url     = {https://doi.org/10.1093/nar/gkm605}
}

@article{sturchlerpierrat1997-9371838,
  author  = {Sturchler-Pierrat, C. and Abramowski, D. and Duke, M. and Wiederhold, K. H. and Mistl, C. and Rothacher, S. and Ledermann, B. and Bürki, K. and others},
  title   = {{Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.24.13287},
  pmid    = {9371838},
  url     = {https://doi.org/10.1073/pnas.94.24.13287}
}

@article{qin2006-16751189,
  author  = {Qin, W. and Yang, T. and Ho, L. and Zhao, Z. and Wang, J. and Chen, L. and Zhao, W. and Thiyagarajan, M. and others},
  title   = {{Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m602909200},
  pmid    = {16751189},
  url     = {https://doi.org/10.1074/jbc.m602909200}
}

@article{sisodia1992-1631093,
  author  = {Sisodia, S. S.},
  title   = {{Beta-amyloid precursor protein cleavage by a membrane-bound protease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.13.6075},
  pmid    = {1631093},
  url     = {https://doi.org/10.1073/pnas.89.13.6075}
}

@article{esparza2013-23225543,
  author  = {Esparza, T. J. and Zhao, H. and Cirrito, JR. and Cairns, N. J. and Bateman, R. J. and Holtzman, D. M. and Brody, D. L.},
  title   = {{Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23748},
  pmid    = {23225543},
  url     = {https://doi.org/10.1002/ana.23748}
}

@article{park2017-28515043,
  author  = {Park, L. and Uekawa, K. and Garcia-Bonilla, L. and Koizumi, K. and Murphy, M. and Pistik, R. and Younkin, L. and Younkin, S. and others},
  title   = {{Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides}},
  journal = {Circulation research},
  year    = {2017},
  doi     = {10.1161/circresaha.117.311054},
  pmid    = {28515043},
  url     = {https://doi.org/10.1161/circresaha.117.311054}
}

@article{suberbielle2015-26615780,
  author  = {Suberbielle, E. and Djukic, B. and Evans, M. and Kim, D. H. and Taneja, P. and Wang, X. and Finucane, M. and Knox, J. and others},
  title   = {{DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice}},
  journal = {Nature communications},
  year    = {2015},
  doi     = {10.1038/ncomms9897},
  pmid    = {26615780},
  url     = {https://doi.org/10.1038/ncomms9897}
}

@article{vardarajan2015-25382023,
  author  = {Vardarajan, B. N. and Zhang, Y. and Lee, J. H. and Cheng, R. and Bohm, C. and Ghani, M. and Reitz, C. and Reyes-Dumeyer, D. and others},
  title   = {{Coding mutations in SORL1 and Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24305},
  pmid    = {25382023},
  url     = {https://doi.org/10.1002/ana.24305}
}

@article{jaeger2010-20559548,
  author  = {Jaeger, P. A. and Pickford, F. and Sun, C. H. and Lucin, K. M. and Masliah, E. and Wyss-Coray, T.},
  title   = {{Regulation of amyloid precursor protein processing by the Beclin 1 complex}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0011102},
  pmid    = {20559548},
  url     = {https://doi.org/10.1371/journal.pone.0011102}
}

@article{tesi2019-30258121,
  author  = {Tesi, N. and van der Lee, S. J. and Hulsman, M. and Jansen, I. E. and Stringa, N. and van Schoor, N. and Meijers-Heijboer, H. and Huisman, M. and others},
  title   = {{Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease}},
  journal = {European journal of human genetics : EJHG},
  year    = {2019},
  doi     = {10.1038/s41431-018-0273-5},
  pmid    = {30258121},
  url     = {https://doi.org/10.1038/s41431-018-0273-5}
}

@article{paez2026-42447420,
  author  = {Paez, A. and Piñol-Ripoll, G. and Carnes-Vendrell, A. and Dakterzada, F. and Barbé, F. and Zetterberg, H. and Dang-Vu, T. T.},
  title   = {{Orexin, Sleep, and Cognition in Alzheimer Disease: Non-REM Oscillatory Activity and Neural Resilience}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000218307},
  pmid    = {42447420},
  url     = {https://doi.org/10.1212/wnl.0000000000218307}
}

@article{tully2003-12654166,
  author  = {Tully, A. M. and Roche, H. M. and Doyle, R. and Fallon, C. and Bruce, I. and Lawlor, B. and Coakley, D. and Gibney, M. J.},
  title   = {{Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study}},
  journal = {The British journal of nutrition},
  year    = {2003},
  doi     = {10.1079/bjn2002804},
  pmid    = {12654166},
  url     = {https://doi.org/10.1079/bjn2002804}
}

@article{fani2020-31839608,
  author  = {Fani, L. and Hilal, S. and Sedaghat, S. and Broer, L. and Licher, S. and Arp, P. P. and van Meurs, J. B. J. and Ikram, M. K. and others},
  title   = {{Telomere Length and the Risk of Alzheimer's Disease: The Rotterdam Study}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-190759},
  pmid    = {31839608},
  url     = {https://doi.org/10.3233/jad-190759}
}

@article{reiman2005-15932949,
  author  = {Reiman, E. M. and Chen, K. and Alexander, G. E. and Caselli, R. J. and Bandy, D. and Osborne, D. and Saunders, A. M. and Hardy, J.},
  title   = {{Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0500579102},
  pmid    = {15932949},
  url     = {https://doi.org/10.1073/pnas.0500579102}
}

@article{vanduijn1994-8075646,
  author  = {van Duijn, C. M. and de Knijff, P. and Cruts, M. and Wehnert, A. and Havekes, L. M. and Hofman, A. and Van Broeckhoven, C.},
  title   = {{Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {1994},
  doi     = {10.1038/ng0594-74},
  pmid    = {8075646},
  url     = {https://doi.org/10.1038/ng0594-74}
}

@article{wijsman2011-21379329,
  author  = {Wijsman, E. M. and Pankratz, N. D. and Choi, Y. and Rothstein, J. H. and Faber, K. M. and Cheng, R. and Lee, J. H. and Bird, T. D. and others},
  title   = {{Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE}},
  journal = {PLoS genetics},
  year    = {2011},
  doi     = {10.1371/journal.pgen.1001308},
  pmid    = {21379329},
  url     = {https://doi.org/10.1371/journal.pgen.1001308}
}

@article{krabbe2013-23577177,
  author  = {Krabbe, G. and Halle, A. and Matyash, V. and Rinnenthal, J. L. and Eom, G. D. and Bernhardt, U. and Miller, K. R. and Prokop, S. and others},
  title   = {{Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0060921},
  pmid    = {23577177},
  url     = {https://doi.org/10.1371/journal.pone.0060921}
}

@article{friedland2017-29267402,
  author  = {Friedland, R. P. and Chapman, M. R.},
  title   = {{The role of microbial amyloid in neurodegeneration}},
  journal = {PLoS pathogens},
  year    = {2017},
  doi     = {10.1371/journal.ppat.1006654},
  pmid    = {29267402},
  url     = {https://doi.org/10.1371/journal.ppat.1006654}
}

@article{schultz2023-37291760,
  author  = {Schultz, S. A. and Shirzadi, Z. and Schultz, A. P. and Liu, L. and Fitzpatrick, C. D. and McDade, E. and Barthelemy, N. R. and Renton, A. and others},
  title   = {{Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease}},
  journal = {Aging cell},
  year    = {2023},
  doi     = {10.1111/acel.13871},
  pmid    = {37291760},
  url     = {https://doi.org/10.1111/acel.13871}
}

@article{holtzman2000-10694577,
  author  = {Holtzman, David M. and Bales, Kelly R. and Tenkova, Tanya and Fagan, Anne M. and Parsadanian, Maia and Sartorius, Leah J. and Mackey, Brian and Olney, John W. and McKeel, Daniel W. and Wozniak, David F. and Paul, Steven M.},
  title   = {{Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {2000},
  doi     = {10.1073/pnas.050004797},
  pmid    = {10694577},
  url     = {https://doi.org/10.1073/pnas.050004797}
}

@article{holtzman2012-22393530,
  author  = {Holtzman, D. M. and Herz, J. and Bu, G.},
  title   = {{Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
  doi     = {10.1101/cshperspect.a006312},
  pmid    = {22393530},
  url     = {https://doi.org/10.1101/cshperspect.a006312}
}

@article{cataldo1997-9236226,
  author  = {Cataldo, A. M. and Barnett, J. L. and Pieroni, C. and Nixon, R. A.},
  title   = {{Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1997},
  doi     = {10.1523/jneurosci.17-16-06142.1997},
  pmid    = {9236226},
  url     = {https://doi.org/10.1523/jneurosci.17-16-06142.1997}
}

@article{poirier1995-8618881,
  author  = {Poirier, J. and Delisle, M. C. and Quirion, R. and Aubert, I. and Farlow, M. and Lahiri, D. and Hui, S. and Bertrand, P. and others},
  title   = {{Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.26.12260},
  pmid    = {8618881},
  url     = {https://doi.org/10.1073/pnas.92.26.12260}
}

@article{wahrle2008-18202749,
  author  = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Kim, J. and Li, A. and Knoten, A. and Jain, S. and Hirsch-Reinshagen, V. and others},
  title   = {{Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci33622},
  pmid    = {18202749},
  url     = {https://doi.org/10.1172/jci33622}
}

@article{cruchaga2011-21220649,
  author  = {Cruchaga, C. and Graff, C. and Chiang, H. H. and Wang, J. and Hinrichs, A. L. and Spiegel, N. and Bertelsen, S. and Mayo, K. and others},
  title   = {{Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.350},
  pmid    = {21220649},
  url     = {https://doi.org/10.1001/archneurol.2010.350}
}

@article{bellenguez2017-28789839,
  author  = {Bellenguez, C. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Le Guennec, K. and Nicolas, G. and Chauhan, G. and Wallon, D. and others},
  title   = {{Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.07.001},
  pmid    = {28789839},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.07.001}
}

@article{huynh2019-31623648,
  author  = {Huynh, T. V. and Wang, C. and Tran, A. C. and Tabor, G. T. and Mahan, T. E. and Francis, C. M. and Finn, M. B. and Spellman, R. and others},
  title   = {{Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0337-1},
  pmid    = {31623648},
  url     = {https://doi.org/10.1186/s13024-019-0337-1}
}

@article{yassine2017-28114437,
  author  = {Yassine, H. N. and Braskie, M. N. and Mack, W. J. and Castor, K. J. and Fonteh, A. N. and Schneider, L. S. and Harrington, M. G. and Chui, H. C.},
  title   = {{Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers: A Review}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.4899},
  pmid    = {28114437},
  url     = {https://doi.org/10.1001/jamaneurol.2016.4899}
}

@article{wingo2019-31135820,
  author  = {Wingo, T. S. and Cutler, D. J. and Wingo, A. P. and Le, N. A. and Rabinovici, G. D. and Miller, B. L. and Lah, J. J. and Levey, A. I.},
  title   = {{Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2019.0648},
  pmid    = {31135820},
  url     = {https://doi.org/10.1001/jamaneurol.2019.0648}
}

@article{farrell2018-30305451,
  author  = {Farrell, M. E. and Chen, X. and Rundle, M. M. and Chan, M. Y. and Wig, G. S. and Park, D. C.},
  title   = {{Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000006469},
  pmid    = {30305451},
  url     = {https://doi.org/10.1212/wnl.0000000000006469}
}

@article{portelius2010-20350302,
  author  = {Portelius, E. and Dean, R. A. and Gustavsson, M. K. and Andreasson, U. and Zetterberg, H. and Siemers, E. and Blennow, K.},
  title   = {{A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2010},
  doi     = {10.1186/alzrt30},
  pmid    = {20350302},
  url     = {https://doi.org/10.1186/alzrt30}
}

@article{dai2006-16945610,
  author  = {Dai, Q. and Borenstein, A. R. and Wu, Y. and Jackson, J. C. and Larson, E. B.},
  title   = {{Fruit and vegetable juices and Alzheimer's disease: the Kame Project}},
  journal = {The American journal of medicine},
  year    = {2006},
  doi     = {10.1016/j.amjmed.2006.03.045},
  pmid    = {16945610},
  url     = {https://doi.org/10.1016/j.amjmed.2006.03.045}
}

@article{pera2017-29018038,
  author  = {Pera, M. and Larrea, D. and Guardia-Laguarta, C. and Montesinos, J. and Velasco, K. R. and Agrawal, R. R. and Xu, Y. and Chan, R. B. and others},
  title   = {{Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease}},
  journal = {The EMBO journal},
  year    = {2017},
  doi     = {10.15252/embj.201796797},
  pmid    = {29018038},
  url     = {https://doi.org/10.15252/embj.201796797}
}

@article{lauretti2020-32006534,
  author  = {Lauretti, E. and Dincer, O. and Praticò, D.},
  title   = {{Glycogen synthase kinase-3 signaling in Alzheimer's disease}},
  journal = {Biochimica et biophysica acta. Molecular cell research},
  year    = {2020},
  doi     = {10.1016/j.bbamcr.2020.118664},
  pmid    = {32006534},
  url     = {https://doi.org/10.1016/j.bbamcr.2020.118664}
}

@article{roe2008-19001165,
  author  = {Roe, C. M. and Mintun, M. A. and D'Angelo, G. and Xiong, C. and Grant, E. A. and Morris, J. C.},
  title   = {{Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.11.1467},
  pmid    = {19001165},
  url     = {https://doi.org/10.1001/archneur.65.11.1467}
}

@article{davis2020-32024799,
  author  = {Davis, A. A. and Inman, C. E. and Wargel, Z. M. and Dube, U. and Freeberg, B. M. and Galluppi, A. and Haines, J. N. and Dhavale, D. D. and others},
  title   = {{APOE genotype regulates pathology and disease progression in synucleinopathy}},
  journal = {Science translational medicine},
  year    = {2020},
  doi     = {10.1126/scitranslmed.aay3069},
  pmid    = {32024799},
  url     = {https://doi.org/10.1126/scitranslmed.aay3069}
}

@article{jucker2011-22028219,
  author  = {Jucker, M. and Walker, L. C.},
  title   = {{Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders}},
  journal = {Annals of neurology},
  year    = {2011},
  doi     = {10.1002/ana.22615},
  pmid    = {22028219},
  url     = {https://doi.org/10.1002/ana.22615}
}

@article{mosconi2008-19076441,
  author  = {Mosconi, L. and Pupi, A. and De Leon, M. J.},
  title   = {{Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2008},
  doi     = {10.1196/annals.1427.007},
  pmid    = {19076441},
  url     = {https://doi.org/10.1196/annals.1427.007}
}

@article{dickerson2011-20562467,
  author  = {Dickerson, B. C. and Wolk, D. A. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2011},
  doi     = {10.1136/jnnp.2009.199505},
  pmid    = {20562467},
  url     = {https://doi.org/10.1136/jnnp.2009.199505}
}

@article{wang2008-19050078,
  author  = {Wang, X. and Su, B. and Siedlak, S. L. and Moreira, P. I. and Fujioka, H. and Wang, Y. and Casadesus, G. and Zhu, X.},
  title   = {{Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2008},
  doi     = {10.1073/pnas.0804871105},
  pmid    = {19050078},
  url     = {https://doi.org/10.1073/pnas.0804871105}
}

@article{destrooper2010-20139999,
  author  = {De Strooper, B. and Vassar, R. and Golde, T.},
  title   = {{The secretases: enzymes with therapeutic potential in Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2010},
  doi     = {10.1038/nrneurol.2009.218},
  pmid    = {20139999},
  url     = {https://doi.org/10.1038/nrneurol.2009.218}
}

@article{saito1993-8464868,
  author  = {Saito, K. and Elce, J. S. and Hamos, J. E. and Nixon, R. A.},
  title   = {{Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.7.2628},
  pmid    = {8464868},
  url     = {https://doi.org/10.1073/pnas.90.7.2628}
}

@article{fitz2021-34099706,
  author  = {Fitz, N. F. and Nam, K. N. and Wolfe, C. M. and Letronne, F. and Playso, B. E. and Iordanova, B. E. and Kozai, T. D. Y. and Biedrzycki, R. J. and others},
  title   = {{Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-23762-0},
  pmid    = {34099706},
  url     = {https://doi.org/10.1038/s41467-021-23762-0}
}

@article{carling2024-39353433,
  author  = {Carling, G. K. and Fan, L. and Foxe, N. R. and Norman, K. and Wong, M. Y. and Zhu, D. and Corona, C. and Razzoli, A. and others},
  title   = {{Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model}},
  journal = {Neuron},
  year    = {2024},
  doi     = {10.1016/j.neuron.2024.09.006},
  pmid    = {39353433},
  url     = {https://doi.org/10.1016/j.neuron.2024.09.006}
}

@article{mattsson2011-21205675,
  author  = {Mattsson, N. and Zetterberg, H. and Bianconi, S. and Yanjanin, N. M. and Fu, R. and Månsson, J. E. and Porter, F. D. and Blennow, K.},
  title   = {{Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e318208f4ab},
  pmid    = {21205675},
  url     = {https://doi.org/10.1212/wnl.0b013e318208f4ab}
}

@article{saunders2022-36041266,
  author  = {Saunders, T. S. and Jenkins, N. and Blennow, K. and Ritchie, C. and Muniz-Terrera, G.},
  title   = {{Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)}},
  journal = {EBioMedicine},
  year    = {2022},
  doi     = {10.1016/j.ebiom.2022.104241},
  pmid    = {36041266},
  url     = {https://doi.org/10.1016/j.ebiom.2022.104241}
}

@article{li2021-34654479,
  author  = {Li, Q. S. and Vasanthakumar, A. and Davis, J. W. and Idler, K. B. and Nho, K. and Waring, J. F. and Saykin, A. J.},
  title   = {{Association of peripheral blood DNA methylation level with Alzheimer's disease progression}},
  journal = {Clinical epigenetics},
  year    = {2021},
  doi     = {10.1186/s13148-021-01179-2},
  pmid    = {34654479},
  url     = {https://doi.org/10.1186/s13148-021-01179-2}
}

@article{garciaalloza2006-17029828,
  author  = {Garcia-Alloza, M. and Robbins, E. M. and Zhang-Nunes, S. X. and Purcell, S. M. and Betensky, R. A. and Raju, S. and Prada, C. and Greenberg, S. M. and others},
  title   = {{Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease}},
  journal = {Neurobiology of disease},
  year    = {2006},
  doi     = {10.1016/j.nbd.2006.08.017},
  pmid    = {17029828},
  url     = {https://doi.org/10.1016/j.nbd.2006.08.017}
}

@article{shafik2021-33402207,
  author  = {Shafik, A. M. and Zhang, F. and Guo, Z. and Dai, Q. and Pajdzik, K. and Li, Y. and Kang, Y. and Yao, B. and others},
  title   = {{N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease}},
  journal = {Genome biology},
  year    = {2021},
  doi     = {10.1186/s13059-020-02249-z},
  pmid    = {33402207},
  url     = {https://doi.org/10.1186/s13059-020-02249-z}
}

@article{konttinen2019-31522977,
  author  = {Konttinen, H. and Cabral-da-Silva, M. E. C. and Ohtonen, S. and Wojciechowski, S. and Shakirzyanova, A. and Caligola, S. and Giugno, R. and Ishchenko, Y. and others},
  title   = {{PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia}},
  journal = {Stem cell reports},
  year    = {2019},
  doi     = {10.1016/j.stemcr.2019.08.004},
  pmid    = {31522977},
  url     = {https://doi.org/10.1016/j.stemcr.2019.08.004}
}

@article{lazaro2025-41022152,
  author  = {Lázaro, Iolanda and Brugulat‐Serrat, Anna and Suárez‐Calvet, Marc and Fauria, Karine and Minguillón, Carolina and Gispert, Juan Domingo and Molinuevo, José Luís and Harris, William S. and others},
  title   = {{Red blood cell ω-3 status and longitudinal cognition in individuals at risk of Alzheimer disease}},
  journal = {Journal of Nutrition},
  year    = {2025},
  doi     = {10.1016/j.tjnut.2025.09.032},
  pmid    = {41022152},
  url     = {https://doi.org/10.1016/j.tjnut.2025.09.032}
}

@article{singh2026-42162487,
  author  = {Singh, Alpana and Denkinger, Marisa N. and Leuzy, Antoine and Dieckhoff, Kari and Liu, Jame and Marques, Tainá M. and Monuki, Edwin S. and Stark, Craig and others},
  title   = {{A plasma protein signature for cerebral amyloid angiopathy}},
  journal = {Acta Neuropathologica},
  year    = {2026},
  doi     = {10.1007/s00401-026-03030-5},
  pmid    = {42162487},
  url     = {https://doi.org/10.1007/s00401-026-03030-5}
}

@article{vilortejedor2025-41092763,
  author  = {Vilor‐Tejedor, Natàlia and Rodrigo, Albert and Genius, Patricia and Rodríguez‐Fernández, Blanca and Anastasi, Federica and Pelkmans, Wiesje and Navarro, Arcadi and Adams, Hieab H.H. and others},
  title   = {{Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment}},
  journal = {NeuroImage Clinical},
  year    = {2025},
  doi     = {10.1016/j.nicl.2025.103889},
  pmid    = {41092763},
  url     = {https://doi.org/10.1016/j.nicl.2025.103889}
}

@article{ahn2026-41890209,
  author  = {Ahn, Young Hyeon and Kang, Jin Gu and Choi, DaHyeon and 김대진 and Yang, Chan-Mo and Lee, S. H. and Lee, Sae Hwan and Jung, Young Hyun and others},
  title   = {{Liver–metabolic stress, apolipoprotein E ε4, and cognition and amyloid burden: findings from the dementia platform Korea trial-ready registry}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2026},
  doi     = {10.3389/fnagi.2026.1773977},
  pmid    = {41890209},
  url     = {https://doi.org/10.3389/fnagi.2026.1773977}
}

@article{beydoun2025-40588577,
  author  = {Beydoun, May A. and Hu, Yi‐Han and Li, Zhiguang and Georgescu, Michael F. and Beydoun, Hind A. and Hooten, Nicole Noren and Walker, Keenan A. and Bouhrara, Mustapha and others},
  title   = {{Alzheimer’s disease polygenic risk’s association with all-cause dementia through the plasma metabolome in the UK Biobank study}},
  journal = {GeroScience},
  year    = {2025},
  doi     = {10.1007/s11357-025-01724-4},
  pmid    = {40588577},
  url     = {https://doi.org/10.1007/s11357-025-01724-4}
}

@article{jiao2025-40877951,
  author  = {Jiao, Haishan and Ge, Yi‐Jun and Huang, Liang-Yu and Liu, Ying and Wu, Bang‐Sheng and Lian, Piaopiao and Hao, Yizhe and Han, Shanshan and others},
  title   = {{MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00887-0},
  pmid    = {40877951},
  url     = {https://doi.org/10.1186/s13024-025-00887-0}
}

@article{hosseinian2020-32433480,
  author  = {Hosseinian, S. and Arefian, E. and Rakhsh-Khorshid, H. and Eivani, M. and Rezayof, A. and Pezeshk, H. and Marashi, S. A.},
  title   = {{A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2020},
  doi     = {10.1038/s41598-020-64452-z},
  pmid    = {32433480},
  url     = {https://doi.org/10.1038/s41598-020-64452-z}
}

@article{albrahim2020-31982903,
  author  = {Albrahim, T.},
  title   = {{The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies}},
  journal = {Neurosciences (Riyadh, Saudi Arabia)},
  year    = {2020},
  doi     = {10.17712/nsj.2020.1.20190037},
  pmid    = {31982903},
  url     = {https://doi.org/10.17712/nsj.2020.1.20190037}
}

@article{lue1999-10487842,
  author  = {Lue, Lih‐Fen and Kuo, Yu‐Min and Roher, Alex E. and Brachova, Libuse and Shen, Yong and Sue, Lucia I. and Beach, Thomas G. and Kurth, Janice H. and Rydel, Russell E. and Rogers, Joseph},
  title   = {{Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease}},
  journal = {American Journal Of Pathology},
  year    = {1999},
  doi     = {10.1016/s0002-9440(10)65184-x},
  pmid    = {10487842},
  url     = {https://doi.org/10.1016/s0002-9440(10)65184-x}
}

@article{sun2026-42066773,
  author  = {Sun, X. and Mews, M. and Wheeler, N. R. and Benchek, P. and Gu, T. and Gomez, L. and Ray, N. and Reitz, C. and Naj, A. C. and Below, J. E. and Tosto, G. and Cornejo-Olivas, M. and others},
  title   = {{Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease}},
  journal = {American Journal of Human Genetics},
  year    = {2026},
  doi     = {10.1016/j.ajhg.2026.04.007},
  pmid    = {42066773},
  url     = {https://doi.org/10.1016/j.ajhg.2026.04.007}
}

@article{thomassen2026-42736378,
  author  = {Thomassen, J. Q. and Leonard, H. and Ulms, B. and Grenier-Boley, B. and Heikkinen, S. and Garcia-González, P. and Castillo-Morales, A. and Kikuchi, M. and Gim, J. and Cao, H. and Küçükali, F. and Amin, N. and others},
  title   = {{APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease}},
  journal = {Nature genetics},
  year    = {2026},
  doi     = {10.1038/s41588-026-02713-9},
  pmid    = {42736378},
  url     = {https://doi.org/10.1038/s41588-026-02713-9}
}

@article{luo2020-30898012,
  author  = {Luo, R. and Su, L. Y. and Li, G. and Yang, J. and Liu, Q. and Yang, L. X. and Zhang, D. F. and Zhou, H. and others},
  title   = {{Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model}},
  journal = {Autophagy},
  year    = {2020},
  doi     = {10.1080/15548627.2019.1596488},
  pmid    = {30898012},
  url     = {https://doi.org/10.1080/15548627.2019.1596488}
}

@article{focke2019-30262517,
  author  = {Focke, C. and Blume, T. and Zott, B. and Shi, Y. and Deussing, M. and Peters, F. and Schmidt, C. and Kleinberger, G. and others},
  title   = {{Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2019},
  doi     = {10.2967/jnumed.118.217703},
  pmid    = {30262517},
  url     = {https://doi.org/10.2967/jnumed.118.217703}
}

@article{wisch2023-36542469,
  author  = {Wisch, J. K. and Butt, O. H. and Gordon, B. A. and Schindler, S. E. and Fagan, A. M. and Henson, R. L. and Yang, C. and Boerwinkle, A. H. and others},
  title   = {{Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awac484},
  pmid    = {36542469},
  url     = {https://doi.org/10.1093/brain/awac484}
}

@article{mahley2016-27174096,
  author  = {Mahley, R. W.},
  title   = {{Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2016},
  doi     = {10.1161/atvbaha.116.307023},
  pmid    = {27174096},
  url     = {https://doi.org/10.1161/atvbaha.116.307023}
}

@article{jun2010-20697030,
  author  = {Jun, G. and Naj, A. C. and Beecham, G. W. and Wang, L. S. and Buros, J. and Gallins, P. J. and Buxbaum, J. D. and Ertekin-Taner, N. and others},
  title   = {{Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2010.201},
  pmid    = {20697030},
  url     = {https://doi.org/10.1001/archneurol.2010.201}
}

@article{bondi2005-15699382,
  author  = {Bondi, M. W. and Houston, W. S. and Eyler, L. T. and Brown, G. G.},
  title   = {{fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000150885.00929.7e},
  pmid    = {15699382},
  url     = {https://doi.org/10.1212/01.wnl.0000150885.00929.7e}
}

@article{youmans2012-23060451,
  author  = {Youmans, K. L. and Tai, L. M. and Nwabuisi-Heath, E. and Jungbauer, L. and Kanekiyo, T. and Gan, M. and Kim, J. and Eimer, W. A. and others},
  title   = {{APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.407957},
  pmid    = {23060451},
  url     = {https://doi.org/10.1074/jbc.m112.407957}
}

@article{claes2021-34301296,
  author  = {Claes, C. and Danhash, E. P. and Hasselmann, J. and Chadarevian, J. P. and Shabestari, S. K. and England, W. E. and Lim, T. E. and Hidalgo, J. L. S. and others},
  title   = {{Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00473-0},
  pmid    = {34301296},
  url     = {https://doi.org/10.1186/s13024-021-00473-0}
}

@article{holstege2017-28537274,
  author  = {Holstege, H. and van der Lee, S. J. and Hulsman, M. and Wong, T. H. and van Rooij, J. G. and Weiss, M. and Louwersheimer, E. and Wolters, F. J. and others},
  title   = {{Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy}},
  journal = {European journal of human genetics : EJHG},
  year    = {2017},
  doi     = {10.1038/ejhg.2017.87},
  pmid    = {28537274},
  url     = {https://doi.org/10.1038/ejhg.2017.87}
}

@article{berlau2009-19255410,
  author  = {Berlau, D. J. and Corrada, M. M. and Head, E. and Kawas, C. H.},
  title   = {{APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/01.wnl.0000343853.00346.a4},
  pmid    = {19255410},
  url     = {https://doi.org/10.1212/01.wnl.0000343853.00346.a4}
}

@article{tai2013-23293020,
  author  = {Tai, L. M. and Bilousova, T. and Jungbauer, L. and Roeske, S. K. and Youmans, K. L. and Yu, C. and Poon, W. W. and Cornwell, L. B. and others},
  title   = {{Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m112.442103},
  pmid    = {23293020},
  url     = {https://doi.org/10.1074/jbc.m112.442103}
}

@article{wadhwani2019-30840313,
  author  = {Wadhwani, A. R. and Affaneh, A. and Van Gulden, S. and Kessler, J. A.},
  title   = {{Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2019},
  doi     = {10.1002/ana.25455},
  pmid    = {30840313},
  url     = {https://doi.org/10.1002/ana.25455}
}

@article{torresmendoza2022-36327127,
  author  = {Torres-Mendoza, B. M. G. and Ortiz, G. G. and Sánchez-Romero, L. and Delgado-Lara, D. L. C. and García Martínez, M. T. and Mireles-Ramírez, M. A. and Cruz Serrano, J. A. and Pacheco Moisés, F. P.},
  title   = {{Dietary fish oil increases catalase activity in patients with probable Alzheimer's disease}},
  journal = {Nutricion hospitalaria},
  year    = {2022},
  doi     = {10.20960/nh.04153},
  pmid    = {36327127},
  url     = {https://doi.org/10.20960/nh.04153}
}

@article{provenzano2013-23420027,
  author  = {Provenzano, F. A. and Muraskin, J. and Tosto, G. and Narkhede, A. and Wasserman, B. T. and Griffith, E. Y. and Guzman, V. A. and Meier, I. B. and others},
  title   = {{White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.1321},
  pmid    = {23420027},
  url     = {https://doi.org/10.1001/jamaneurol.2013.1321}
}

@article{dehaan2012-22915996,
  author  = {de Haan, W. and Mott, K. and van Straaten, E. C. and Scheltens, P. and Stam, C. J.},
  title   = {{Activity dependent degeneration explains hub vulnerability in Alzheimer's disease}},
  journal = {PLoS computational biology},
  year    = {2012},
  doi     = {10.1371/journal.pcbi.1002582},
  pmid    = {22915996},
  url     = {https://doi.org/10.1371/journal.pcbi.1002582}
}

@article{wang2015-25716355,
  author  = {Wang, L. and Benzinger, T. L. and Hassenstab, J. and Blazey, T. and Owen, C. and Liu, J. and Fagan, A. M. and Morris, J. C. and others},
  title   = {{Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000001401},
  pmid    = {25716355},
  url     = {https://doi.org/10.1212/wnl.0000000000001401}
}

@article{hashimoto2012-23100439,
  author  = {Hashimoto, T. and Serrano-Pozo, A. and Hori, Y. and Adams, K. W. and Takeda, S. and Banerji, A. O. and Mitani, A. and Joyner, D. and others},
  title   = {{Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.1542-12.2012},
  pmid    = {23100439},
  url     = {https://doi.org/10.1523/jneurosci.1542-12.2012}
}

@article{bassil2020-31759806,
  author  = {Bassil, F. and Brown, H. J. and Pattabhiraman, S. and Iwasyk, J. E. and Maghames, C. M. and Meymand, E. S. and Cox, T. O. and Riddle, D. M. and others},
  title   = {{Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2019.10.010},
  pmid    = {31759806},
  url     = {https://doi.org/10.1016/j.neuron.2019.10.010}
}

@article{wildburger2017-28842697,
  author  = {Wildburger, N. C. and Esparza, T. J. and LeDuc, R. D. and Fellers, R. T. and Thomas, P. M. and Cairns, N. J. and Kelleher, N. L. and Bateman, R. J. and others},
  title   = {{Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-10422-x},
  pmid    = {28842697},
  url     = {https://doi.org/10.1038/s41598-017-10422-x}
}

@article{hokama2014-23595620,
  author  = {Hokama, M. and Oka, S. and Leon, J. and Ninomiya, T. and Honda, H. and Sasaki, K. and Iwaki, T. and Ohara, T. and others},
  title   = {{Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study}},
  journal = {Cerebral cortex (New York, N.Y. : 1991)},
  year    = {2014},
  doi     = {10.1093/cercor/bht101},
  pmid    = {23595620},
  url     = {https://doi.org/10.1093/cercor/bht101}
}

@article{neth2017-29163128,
  author  = {Neth, B. J. and Craft, S.},
  title   = {{Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00345},
  pmid    = {29163128},
  url     = {https://doi.org/10.3389/fnagi.2017.00345}
}

@article{wegiel2007-17237937,
  author  = {Wegiel, J. and Kuchna, I. and Nowicki, K. and Frackowiak, J. and Mazur-Kolecka, B. and Imaki, H. and Mehta, P. D. and others},
  title   = {{Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration}},
  journal = {Acta neuropathologica},
  year    = {2007},
  doi     = {10.1007/s00401-006-0191-4},
  pmid    = {17237937},
  url     = {https://doi.org/10.1007/s00401-006-0191-4}
}

@article{butterfield2018-29562527,
  author  = {Butterfield, D. A. and Boyd-Kimball, D.},
  title   = {{Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-170543},
  pmid    = {29562527},
  url     = {https://doi.org/10.3233/jad-170543}
}

@article{yuzwa2014-24759912,
  author  = {Yuzwa, S. A. and Vocadlo, D. J.},
  title   = {{O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond}},
  journal = {Chemical Society reviews},
  year    = {2014},
  doi     = {10.1039/c4cs00038b},
  pmid    = {24759912},
  url     = {https://doi.org/10.1039/c4cs00038b}
}

@article{cirrito2005-16239972,
  author  = {Cirrito, JR. and Deane, R. and Fagan, A. M. and Spinner, M. L. and Parsadanian, M. and Finn, M. B. and Jiang, H. and Prior, J. L. and others},
  title   = {{P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model}},
  journal = {The Journal of clinical investigation},
  year    = {2005},
  doi     = {10.1172/jci25247},
  pmid    = {16239972},
  url     = {https://doi.org/10.1172/jci25247}
}

@article{koo1990-1689489,
  author  = {Koo, E. H. and Sisodia, S. S. and Archer, D. R. and Martin, L. J. and Weidemann, A. and Beyreuther, K. and Fischer, P. and Masters, C. L. and others},
  title   = {{Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1990},
  doi     = {10.1073/pnas.87.4.1561},
  pmid    = {1689489},
  url     = {https://doi.org/10.1073/pnas.87.4.1561}
}

@article{ly2013-23202730,
  author  = {Ly, P. T. and Wu, Y. and Zou, H. and Wang, R. and Zhou, W. and Kinoshita, A. and Zhang, M. and Yang, Y. and others},
  title   = {{Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes}},
  journal = {The Journal of clinical investigation},
  year    = {2013},
  doi     = {10.1172/jci64516},
  pmid    = {23202730},
  url     = {https://doi.org/10.1172/jci64516}
}

@article{busciglio1993-8446635,
  author  = {Busciglio, J. and Gabuzda, D. H. and Matsudaira, P. and Yankner, B. A.},
  title   = {{Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.5.2092},
  pmid    = {8446635},
  url     = {https://doi.org/10.1073/pnas.90.5.2092}
}

@article{cheng2007-17548355,
  author  = {Cheng, I. H. and Scearce-Levie, K. and Legleiter, J. and Palop, J. J. and Gerstein, H. and Bien-Ly, N. and Puoliväli, J. and Lesné, S. and others},
  title   = {{Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m701078200},
  pmid    = {17548355},
  url     = {https://doi.org/10.1074/jbc.m701078200}
}

@article{tomita1997-9050898,
  author  = {Tomita, T. and Maruyama, K. and Saido, T. C. and Kume, H. and Shinozaki, K. and Tokuhiro, S. and Capell, A. and Walter, J. and others},
  title   = {{The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.5.2025},
  pmid    = {9050898},
  url     = {https://doi.org/10.1073/pnas.94.5.2025}
}

@article{hemming2005-16154999,
  author  = {Hemming, M. L. and Selkoe, D. J.},
  title   = {{Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508460200},
  pmid    = {16154999},
  url     = {https://doi.org/10.1074/jbc.m508460200}
}

@article{caporaso1992-1557413,
  author  = {Caporaso, G. L. and Gandy, S. E. and Buxbaum, J. D. and Ramabhadran, T. V. and Greengard, P.},
  title   = {{Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.7.3055},
  pmid    = {1557413},
  url     = {https://doi.org/10.1073/pnas.89.7.3055}
}

@article{villemagne2009-20008660,
  author  = {Villemagne, V. L. and Ataka, S. and Mizuno, T. and Brooks, W. S. and Wada, Y. and Kondo, M. and Jones, G. and Watanabe, Y. and others},
  title   = {{High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2009.285},
  pmid    = {20008660},
  url     = {https://doi.org/10.1001/archneurol.2009.285}
}

@article{gomes2019-31414210,
  author  = {Gomes, L. A. and Hipp, S. A. and Rijal Upadhaya, A. and Balakrishnan, K. and Ospitalieri, S. and Koper, M. J. and Largo-Barrientos, P. and Uytterhoeven, V. and others},
  title   = {{Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02053-5},
  pmid    = {31414210},
  url     = {https://doi.org/10.1007/s00401-019-02053-5}
}

@article{castillo2017-29259249,
  author  = {Castillo, E. and Leon, J. and Mazzei, G. and Abolhassani, N. and Haruyama, N. and Saito, T. and Saido, T. and Hokama, M. and others},
  title   = {{Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-17999-3},
  pmid    = {29259249},
  url     = {https://doi.org/10.1038/s41598-017-17999-3}
}

@article{qiu2021-34526055,
  author  = {Qiu, S. and Palavicini, J. P. and Wang, J. and Gonzalez, N. S. and He, S. and Dustin, E. and Zou, C. and Ding, L. and others},
  title   = {{Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00488-7},
  pmid    = {34526055},
  url     = {https://doi.org/10.1186/s13024-021-00488-7}
}

@article{liu2020-32941599,
  author  = {Liu, T. and Zhu, B. and Liu, Y. and Zhang, X. and Yin, J. and Li, X. and Jiang, L. and Hodges, A. P. and others},
  title   = {{Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE}},
  journal = {The Journal of experimental medicine},
  year    = {2020},
  doi     = {10.1084/jem.20200474},
  pmid    = {32941599},
  url     = {https://doi.org/10.1084/jem.20200474}
}

@article{jung2025-40149001,
  author  = {Jung, E. S. and Choi, H. and Mook-Jung, I.},
  title   = {{Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00825-0},
  pmid    = {40149001},
  url     = {https://doi.org/10.1186/s13024-025-00825-0}
}

@article{zhou2023-36658241,
  author  = {Zhou, Y. and Tada, M. and Cai, Z. and Andhey, P. S. and Swain, A. and Miller, K. R. and Gilfillan, S. and Artyomov, M. N. and others},
  title   = {{Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-022-01403-y},
  pmid    = {36658241},
  url     = {https://doi.org/10.1038/s41590-022-01403-y}
}

@article{brenowitz2014-24270205,
  author  = {Brenowitz, W. D. and Monsell, S. E. and Schmitt, F. A. and Kukull, W. A. and Nelson, P. T.},
  title   = {{Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-131880},
  pmid    = {24270205},
  url     = {https://doi.org/10.3233/jad-131880}
}

@article{sennik2017-27911311,
  author  = {Sennik, S. and Schweizer, T. A. and Fischer, C. E. and Munoz, D. G.},
  title   = {{Risk Factors and Pathological Substrates Associated with Agitation/Aggression in Alzheimer's Disease: A Preliminary Study using NACC Data}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160780},
  pmid    = {27911311},
  url     = {https://doi.org/10.3233/jad-160780}
}

@article{vidal2000-10781099,
  author  = {Vidal, R. and Revesz, T. and Rostagno, A. and Kim, E. and Holton, J. L. and Bek, T. and Bojsen-Møller, M. and Braendgaard, H. and others},
  title   = {{A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2000},
  doi     = {10.1073/pnas.080076097},
  pmid    = {10781099},
  url     = {https://doi.org/10.1073/pnas.080076097}
}

@article{shaftel2008-18302763,
  author  = {Shaftel, S. S. and Griffin, W. S. and O'Banion, M. K.},
  title   = {{The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-7},
  pmid    = {18302763},
  url     = {https://doi.org/10.1186/1742-2094-5-7}
}

@article{duyan1997-9144231,
  author  = {Du Yan, S. and Zhu, H. and Fu, J. and Yan, S. F. and Roher, A. and Tourtellotte, W. W. and Rajavashisth, T. and Chen, X. and others},
  title   = {{Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.10.5296},
  pmid    = {9144231},
  url     = {https://doi.org/10.1073/pnas.94.10.5296}
}

@article{oveisgharan2025-40845264,
  author  = {Oveisgharan, Shahram and Yu, Lei and Yang, Jingyun and Agrawal, Sonal and Vialle, Ricardo A. and Lopes, Kátia de Paiva and Tasaki, Shinya and Wang, Yanling and others},
  title   = {{Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000214024},
  pmid    = {40845264},
  url     = {https://doi.org/10.1212/wnl.0000000000214024}
}

@article{bonham2025-40443531,
  author  = {Bonham, Luke W. and Sirkis, Daniel W. and Pang, Alina P.S. and Sugrue, Leo P. and Santamaría‐García, Hernando A and Ibáñez, Agustín M. and Miller, Bruce Leonard and Yokoyama, Jennifer S. and others},
  title   = {{DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophy}},
  journal = {npj Dementia},
  year    = {2025},
  doi     = {10.1038/s44400-025-00007-1},
  pmid    = {40443531},
  url     = {https://doi.org/10.1038/s44400-025-00007-1}
}

@article{perfetto2026-42556583,
  author  = {Perfetto, Sofia E. and Ruthirakuhan, Myuri T. and Wong, Yuen Yan and Ryoo, Si Won and Huang, Celine H.L. and Fan, Fan and Chenoweth, Meghan J. and Nestor, Sean M. and others},
  title   = {{Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities}},
  journal = {Journal of Affective Disorders},
  year    = {2026},
  doi     = {10.1016/j.jad.2026.122353},
  pmid    = {42556583},
  url     = {https://doi.org/10.1016/j.jad.2026.122353}
}

@article{drenth2017-28539135,
  author  = {Drenth, H. and Zuidema, S. U. and Krijnen, W. P. and Bautmans, I. and van der Schans, C. and Hobbelen, H.},
  title   = {{Association between advanced glycation end-products and functional performance in Alzheimer's disease and mixed dementia}},
  journal = {International psychogeriatrics},
  year    = {2017},
  doi     = {10.1017/s1041610217000886},
  pmid    = {28539135},
  url     = {https://doi.org/10.1017/s1041610217000886}
}

@article{strittmatter1994-7972031,
  author  = {Strittmatter, W. J. and Saunders, A. M. and Goedert, M. and Weisgraber, K. H. and Dong, L. M. and Jakes, R. and Huang, D. Y. and Pericak-Vance, M. and others},
  title   = {{Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.23.11183},
  pmid    = {7972031},
  url     = {https://doi.org/10.1073/pnas.91.23.11183}
}

@article{wahrle2005-16207708,
  author  = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Hartman, R. E. and Bales, K. R. and Paul, S. M. and Holtzman, D. M.},
  title   = {{Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508780200},
  pmid    = {16207708},
  url     = {https://doi.org/10.1074/jbc.m508780200}
}

@article{evans1995-7846048,
  author  = {Evans, K. C. and Berger, E. P. and Cho, C. G. and Weisgraber, K. H. and Lansbury, P. T.},
  title   = {{Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.3.763},
  pmid    = {7846048},
  url     = {https://doi.org/10.1073/pnas.92.3.763}
}

@article{beecham2009-19118814,
  author  = {Beecham, G. W. and Martin, E. R. and Li, Y. J. and Slifer, M. A. and Gilbert, JR. and Haines, J. L. and Pericak-Vance, M. A.},
  title   = {{Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {2009},
  doi     = {10.1016/j.ajhg.2008.12.008},
  pmid    = {19118814},
  url     = {https://doi.org/10.1016/j.ajhg.2008.12.008}
}

@article{butterfield2020-32036033,
  author  = {Butterfield, D. A. and Mattson, M. P.},
  title   = {{Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2020},
  doi     = {10.1016/j.nbd.2020.104795},
  pmid    = {32036033},
  url     = {https://doi.org/10.1016/j.nbd.2020.104795}
}

@article{nelson2013-23771217,
  author  = {Nelson, P. T. and Pious, N. M. and Jicha, G. A. and Wilcock, D. M. and Fardo, D. W. and Estus, S. and Rebeck, G. W.},
  title   = {{APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2013},
  doi     = {10.1097/nen.0b013e31829a25b9},
  pmid    = {23771217},
  url     = {https://doi.org/10.1097/nen.0b013e31829a25b9}
}

@article{takei2009-19442637,
  author  = {Takei, N. and Miyashita, A. and Tsukie, T. and Arai, H. and Asada, T. and Imagawa, M. and Shoji, M. and Higuchi, S. and others},
  title   = {{Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese}},
  journal = {Genomics},
  year    = {2009},
  doi     = {10.1016/j.ygeno.2009.01.003},
  pmid    = {19442637},
  url     = {https://doi.org/10.1016/j.ygeno.2009.01.003}
}

@article{kerchner2014-24453080,
  author  = {Kerchner, G. A. and Berdnik, D. and Shen, J. C. and Bernstein, J. D. and Fenesy, M. C. and Deutsch, G. K. and Wyss-Coray, T. and Rutt, B. K.},
  title   = {{APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000154},
  pmid    = {24453080},
  url     = {https://doi.org/10.1212/wnl.0000000000000154}
}

@article{caselli2011-21502596,
  author  = {Caselli, R. J. and Dueck, A. C. and Locke, D. E. and Hoffman-Snyder, C. R. and Woodruff, B. K. and Rapcsak, S. Z. and Reiman, E. M.},
  title   = {{Longitudinal modeling of frontal cognition in APOE ε4 homozygotes, heterozygotes, and noncarriers}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e3182167147},
  pmid    = {21502596},
  url     = {https://doi.org/10.1212/wnl.0b013e3182167147}
}

@article{jankowsky2005-15917461,
  author  = {Jankowsky, J. L. and Melnikova, T. and Fadale, D. J. and Xu, G. M. and Slunt, H. H. and Gonzales, V. and Younkin, L. H. and Younkin, S. G. and others},
  title   = {{Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.5080-04.2005},
  pmid    = {15917461},
  url     = {https://doi.org/10.1523/jneurosci.5080-04.2005}
}

@article{bonda2011-21349442,
  author  = {Bonda, D. J. and Lee, H. G. and Camins, A. and Pallàs, M. and Casadesus, G. and Smith, M. A. and Zhu, X.},
  title   = {{The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations}},
  journal = {The Lancet. Neurology},
  year    = {2011},
  doi     = {10.1016/s1474-4422(11)70013-8},
  pmid    = {21349442},
  url     = {https://doi.org/10.1016/s1474-4422(11)70013-8}
}

@article{liu2011-21598254,
  author  = {Liu, Y. and Liu, F. and Grundke-Iqbal, I. and Iqbal, K. and Gong, C. X.},
  title   = {{Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes}},
  journal = {The Journal of pathology},
  year    = {2011},
  doi     = {10.1002/path.2912},
  pmid    = {21598254},
  url     = {https://doi.org/10.1002/path.2912}
}

@article{hsiao1995-7576662,
  author  = {Hsiao, K. K. and Borchelt, D. R. and Olson, K. and Johannsdottir, R. and Kitt, C. and Yunis, W. and Xu, S. and Eckman, C. and others},
  title   = {{Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins}},
  journal = {Neuron},
  year    = {1995},
  doi     = {10.1016/0896-6273(95)90107-8},
  pmid    = {7576662},
  url     = {https://doi.org/10.1016/0896-6273(95)90107-8}
}

@article{selkoe1988-3140239,
  author  = {Selkoe, D. J. and Podlisny, M. B. and Joachim, C. L. and Vickers, E. A. and Lee, G. and Fritz, L. C. and Oltersdorf, T.},
  title   = {{Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1988},
  doi     = {10.1073/pnas.85.19.7341},
  pmid    = {3140239},
  url     = {https://doi.org/10.1073/pnas.85.19.7341}
}

@article{naslund1994-8078890,
  author  = {Näslund, J. and Schierhorn, A. and Hellman, U. and Lannfelt, L. and Roses, A. D. and Tjernberg, L. O. and Silberring, J. and Gandy, S. E. and others},
  title   = {{Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.18.8378},
  pmid    = {8078890},
  url     = {https://doi.org/10.1073/pnas.91.18.8378}
}

@article{destrooper2007-17268505,
  author  = {De Strooper, B.},
  title   = {{Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease}},
  journal = {EMBO reports},
  year    = {2007},
  doi     = {10.1038/sj.embor.7400897},
  pmid    = {17268505},
  url     = {https://doi.org/10.1038/sj.embor.7400897}
}

@article{puzzo2011-21472769,
  author  = {Puzzo, D. and Privitera, L. and Fa', M. and Staniszewski, A. and Hashimoto, G. and Aziz, F. and Sakurai, M. and Ribe, E. M. and others},
  title   = {{Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory}},
  journal = {Annals of neurology},
  year    = {2011},
  doi     = {10.1002/ana.22313},
  pmid    = {21472769},
  url     = {https://doi.org/10.1002/ana.22313}
}

@article{rogers1999-10037734,
  author  = {Rogers, J. T. and Leiter, L. M. and McPhee, J. and Cahill, C. M. and Zhan, S. S. and Potter, H. and Nilsson, L. N.},
  title   = {{Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences}},
  journal = {The Journal of biological chemistry},
  year    = {1999},
  doi     = {10.1074/jbc.274.10.6421},
  pmid    = {10037734},
  url     = {https://doi.org/10.1074/jbc.274.10.6421}
}

@article{areagomez2018-29491396,
  author  = {Area-Gomez, E. and de Groof, A. and Bonilla, E. and Montesinos, J. and Tanji, K. and Boldogh, I. and Pon, L. and Schon, E. A.},
  title   = {{A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease}},
  journal = {Cell death \& disease},
  year    = {2018},
  doi     = {10.1038/s41419-017-0215-0},
  pmid    = {29491396},
  url     = {https://doi.org/10.1038/s41419-017-0215-0}
}

@article{takeuchi2000-10880403,
  author  = {Takeuchi, A. and Irizarry, M. C. and Duff, K. and Saido, T. C. and Hsiao Ashe, K. and Hasegawa, M. and Mann, D. M. and Hyman, B. T. and others},
  title   = {{Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss}},
  journal = {The American journal of pathology},
  year    = {2000},
  doi     = {10.1016/s0002-9440(10)64544-0},
  pmid    = {10880403},
  url     = {https://doi.org/10.1016/s0002-9440(10)64544-0}
}

@article{vanacker2019-31159836,
  author  = {Van Acker, Z. P. and Bretou, M. and Annaert, W.},
  title   = {{Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0323-7},
  pmid    = {31159836},
  url     = {https://doi.org/10.1186/s13024-019-0323-7}
}

@article{salih2019-32274467,
  author  = {Salih, D. A. and Bayram, S. and Guelfi, S. and Reynolds, R. H. and Shoai, M. and Ryten, M. and Brenton, J. W. and Zhang, D. and others},
  title   = {{Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk}},
  journal = {Brain communications},
  year    = {2019},
  doi     = {10.1093/braincomms/fcz022},
  pmid    = {32274467},
  url     = {https://doi.org/10.1093/braincomms/fcz022}
}

@article{uryu2002-11784789,
  author  = {Uryu, K. and Laurer, H. and McIntosh, T. and Praticò, D. and Martinez, D. and Leight, S. and Lee, V. M. and Trojanowski, J. Q.},
  title   = {{Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2002},
  doi     = {10.1523/jneurosci.22-02-00446.2002},
  pmid    = {11784789},
  url     = {https://doi.org/10.1523/jneurosci.22-02-00446.2002}
}

@article{kanekiyo2014-24904407,
  author  = {Kanekiyo, T. and Bu, G.},
  title   = {{The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2014},
  doi     = {10.3389/fnagi.2014.00093},
  pmid    = {24904407},
  url     = {https://doi.org/10.3389/fnagi.2014.00093}
}

@article{revesz2009-19225789,
  author  = {Revesz, T. and Holton, J. L. and Lashley, T. and Plant, G. and Frangione, B. and Rostagno, A. and Ghiso, J.},
  title   = {{Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies}},
  journal = {Acta neuropathologica},
  year    = {2009},
  doi     = {10.1007/s00401-009-0501-8},
  pmid    = {19225789},
  url     = {https://doi.org/10.1007/s00401-009-0501-8}
}

@article{lee2010-20552234,
  author  = {Lee, C. Y. and Landreth, G. E.},
  title   = {{The role of microglia in amyloid clearance from the AD brain}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2010},
  doi     = {10.1007/s00702-010-0433-4},
  pmid    = {20552234},
  url     = {https://doi.org/10.1007/s00702-010-0433-4}
}

@article{sasaki1998-9777946,
  author  = {Sasaki, N. and Fukatsu, R. and Tsuzuki, K. and Hayashi, Y. and Yoshida, T. and Fujii, N. and Koike, T. and Wakayama, I. and others},
  title   = {{Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases}},
  journal = {The American journal of pathology},
  year    = {1998},
  doi     = {10.1016/s0002-9440(10)65659-3},
  pmid    = {9777946},
  url     = {https://doi.org/10.1016/s0002-9440(10)65659-3}
}

@article{martin2000-10869235,
  author  = {Martin, E. R. and Lai, E. H. and Gilbert, JR. and Rogala, A. R. and Afshari, A. J. and Riley, J. and Finch, K. L. and Stevens, J. F. and others},
  title   = {{SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {2000},
  doi     = {10.1086/303003},
  pmid    = {10869235},
  url     = {https://doi.org/10.1086/303003}
}

@article{chen2011-21118811,
  author  = {Chen, H. K. and Ji, Z. S. and Dodson, S. E. and Miranda, R. D. and Rosenblum, C. I. and Reynolds, I. J. and Freedman, S. B. and Weisgraber, K. H. and others},
  title   = {{Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.151084},
  pmid    = {21118811},
  url     = {https://doi.org/10.1074/jbc.m110.151084}
}

@article{buttini2002-12486146,
  author  = {Buttini, M. and Yu, G. Q. and Shockley, K. and Huang, Y. and Jones, B. and Masliah, E. and Mallory, M. and Yeo, T. and others},
  title   = {{Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2002},
  doi     = {10.1523/jneurosci.22-24-10539.2002},
  pmid    = {12486146},
  url     = {https://doi.org/10.1523/jneurosci.22-24-10539.2002}
}

@article{beeri2006-16682673,
  author  = {Beeri, M. S. and Rapp, M. and Silverman, J. M. and Schmeidler, J. and Grossman, H. T. and Fallon, J. T. and Purohit, D. P. and Perl, D. P. and others},
  title   = {{Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000210447.19748.0b},
  pmid    = {16682673},
  url     = {https://doi.org/10.1212/01.wnl.0000210447.19748.0b}
}

@article{wells2019-31564434,
  author  = {Wells, H. R. R. and Freidin, M. B. and Zainul Abidin, F. N. and Payton, A. and Dawes, P. and Munro, K. J. and Morton, C. C. and Moore, D. R. and others},
  title   = {{GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank}},
  journal = {American journal of human genetics},
  year    = {2019},
  doi     = {10.1016/j.ajhg.2019.09.008},
  pmid    = {31564434},
  url     = {https://doi.org/10.1016/j.ajhg.2019.09.008}
}

@article{ferreira2011-21914486,
  author  = {Ferreira, S. T. and Klein, W. L.},
  title   = {{The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease}},
  journal = {Neurobiology of learning and memory},
  year    = {2011},
  doi     = {10.1016/j.nlm.2011.08.003},
  pmid    = {21914486},
  url     = {https://doi.org/10.1016/j.nlm.2011.08.003}
}

@article{hammond2020-32632135,
  author  = {Hammond, T. C. and Xing, X. and Wang, C. and Ma, D. and Nho, K. and Crane, P. K. and Elahi, F. and Ziegler, D. A. and others},
  title   = {{β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline}},
  journal = {Communications biology},
  year    = {2020},
  doi     = {10.1038/s42003-020-1079-x},
  pmid    = {32632135},
  url     = {https://doi.org/10.1038/s42003-020-1079-x}
}

@article{defelice2014-24931033,
  author  = {De Felice, F. G. and Ferreira, S. T.},
  title   = {{Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease}},
  journal = {Diabetes},
  year    = {2014},
  doi     = {10.2337/db13-1954},
  pmid    = {24931033},
  url     = {https://doi.org/10.2337/db13-1954}
}

@article{jackson2013-23794448,
  author  = {Jackson, K. and Barisone, G. A. and Diaz, E. and Jin, L. W. and DeCarli, C. and Despa, F.},
  title   = {{Amylin deposition in the brain: A second amyloid in Alzheimer disease?}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23956},
  pmid    = {23794448},
  url     = {https://doi.org/10.1002/ana.23956}
}

@article{ramirez2017-28729832,
  author  = {Ramirez, A. I. and de Hoz, R. and Salobrar-Garcia, E. and Salazar, J. J. and Rojas, B. and Ajoy, D. and López-Cuenca, I. and Rojas, P. and others},
  title   = {{The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00214},
  pmid    = {28729832},
  url     = {https://doi.org/10.3389/fnagi.2017.00214}
}

@article{butterfield2006-16466929,
  author  = {Butterfield, D. A. and Poon, H. F. and St Clair, D. and Keller, J. N. and Pierce, W. M. and Klein, J. B. and Markesbery, W. R.},
  title   = {{Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2006},
  doi     = {10.1016/j.nbd.2005.11.002},
  pmid    = {16466929},
  url     = {https://doi.org/10.1016/j.nbd.2005.11.002}
}

@article{ginsberg2010-20655510,
  author  = {Ginsberg, S. D. and Alldred, M. J. and Counts, S. E. and Cataldo, A. M. and Neve, R. L. and Jiang, Y. and Wuu, J. and Chao, M. V. and others},
  title   = {{Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression}},
  journal = {Biological psychiatry},
  year    = {2010},
  doi     = {10.1016/j.biopsych.2010.05.030},
  pmid    = {20655510},
  url     = {https://doi.org/10.1016/j.biopsych.2010.05.030}
}

@article{sultana2009-19288120,
  author  = {Sultana, R. and Perluigi, M. and Butterfield, D. A.},
  title   = {{Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis}},
  journal = {Acta neuropathologica},
  year    = {2009},
  doi     = {10.1007/s00401-009-0517-0},
  pmid    = {19288120},
  url     = {https://doi.org/10.1007/s00401-009-0517-0}
}

@article{vanbergen2016-27748454,
  author  = {van Bergen, J. M. and Li, X. and Hua, J. and Schreiner, S. J. and Steininger, S. C. and Quevenco, F. C. and Wyss, M. and Gietl, A. F. and others},
  title   = {{Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment}},
  journal = {Scientific reports},
  year    = {2016},
  doi     = {10.1038/srep35514},
  pmid    = {27748454},
  url     = {https://doi.org/10.1038/srep35514}
}

@article{johnsonwood1997-9037091,
  author  = {Johnson-Wood, K. and Lee, M. and Motter, R. and Hu, K. and Gordon, G. and Barbour, R. and Khan, K. and Gordon, M. and others},
  title   = {{Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.4.1550},
  pmid    = {9037091},
  url     = {https://doi.org/10.1073/pnas.94.4.1550}
}

@article{butterfield2013-23249141,
  author  = {Butterfield, D. A. and Swomley, A. M. and Sultana, R.},
  title   = {{Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression}},
  journal = {Antioxidants \& redox signaling},
  year    = {2013},
  doi     = {10.1089/ars.2012.5027},
  pmid    = {23249141},
  url     = {https://doi.org/10.1089/ars.2012.5027}
}

@article{buxbaum1990-2116015,
  author  = {Buxbaum, J. D. and Gandy, S. E. and Cicchetti, P. and Ehrlich, M. E. and Czernik, A. J. and Fracasso, R. P. and Ramabhadran, T. V. and Unterbeck, A. J. and others},
  title   = {{Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1990},
  doi     = {10.1073/pnas.87.15.6003},
  pmid    = {2116015},
  url     = {https://doi.org/10.1073/pnas.87.15.6003}
}

@article{greenfield1999-9892704,
  author  = {Greenfield, J. P. and Tsai, J. and Gouras, G. K. and Hai, B. and Thinakaran, G. and Checler, F. and Sisodia, S. S. and Greengard, P. and others},
  title   = {{Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1999},
  doi     = {10.1073/pnas.96.2.742},
  pmid    = {9892704},
  url     = {https://doi.org/10.1073/pnas.96.2.742}
}

@article{citron1994-7991571,
  author  = {Citron, M. and Vigo-Pelfrey, C. and Teplow, D. B. and Miller, C. and Schenk, D. and Johnston, J. and Winblad, B. and Venizelos, N. and others},
  title   = {{Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.25.11993},
  pmid    = {7991571},
  url     = {https://doi.org/10.1073/pnas.91.25.11993}
}

@article{xu1997-9108049,
  author  = {Xu, H. and Sweeney, D. and Wang, R. and Thinakaran, G. and Lo, A. C. and Sisodia, S. S. and Greengard, P. and Gandy, S.},
  title   = {{Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.8.3748},
  pmid    = {9108049},
  url     = {https://doi.org/10.1073/pnas.94.8.3748}
}

@article{cras1991-1652752,
  author  = {Cras, P. and Kawai, M. and Lowery, D. and Gonzalez-DeWhitt, P. and Greenberg, B. and Perry, G.},
  title   = {{Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1991},
  doi     = {10.1073/pnas.88.17.7552},
  pmid    = {1652752},
  url     = {https://doi.org/10.1073/pnas.88.17.7552}
}

@article{citron1996-8917563,
  author  = {Citron, M. and Diehl, T. S. and Gordon, G. and Biere, A. L. and Seubert, P. and Selkoe, D. J.},
  title   = {{Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1996},
  doi     = {10.1073/pnas.93.23.13170},
  pmid    = {8917563},
  url     = {https://doi.org/10.1073/pnas.93.23.13170}
}

@article{jankowsky2005-16279840,
  author  = {Jankowsky, J. L. and Slunt, H. H. and Gonzales, V. and Savonenko, A. V. and Wen, J. C. and Jenkins, N. A. and Copeland, N. G. and Younkin, L. H. and others},
  title   = {{Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease}},
  journal = {PLoS medicine},
  year    = {2005},
  doi     = {10.1371/journal.pmed.0020355},
  pmid    = {16279840},
  url     = {https://doi.org/10.1371/journal.pmed.0020355}
}

@article{bakernigh2015-25732182,
  author  = {Baker-Nigh, A. and Vahedi, S. and Davis, E. G. and Weintraub, S. and Bigio, E. H. and Klein, W. L. and Geula, C.},
  title   = {{Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2015},
  doi     = {10.1093/brain/awv024},
  pmid    = {25732182},
  url     = {https://doi.org/10.1093/brain/awv024}
}

@article{xia1997-9223340,
  author  = {Xia, W. and Zhang, J. and Perez, R. and Koo, E. H. and Selkoe, D. J.},
  title   = {{Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.15.8208},
  pmid    = {9223340},
  url     = {https://doi.org/10.1073/pnas.94.15.8208}
}

@article{zetterberg2011-22194817,
  author  = {Zetterberg, H. and Mörtberg, E. and Song, L. and Chang, L. and Provuncher, G. K. and Patel, P. P. and Ferrell, E. and Fournier, D. R. and others},
  title   = {{Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans}},
  journal = {PloS one},
  year    = {2011},
  doi     = {10.1371/journal.pone.0028263},
  pmid    = {22194817},
  url     = {https://doi.org/10.1371/journal.pone.0028263}
}

@article{ayton2015-25716857,
  author  = {Ayton, S. and Lei, P. and Hare, D. J. and Duce, J. A. and George, J. L. and Adlard, P. A. and McLean, C. and Rogers, J. T. and others},
  title   = {{Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.3439-14.2015},
  pmid    = {25716857},
  url     = {https://doi.org/10.1523/jneurosci.3439-14.2015}
}

@article{barberocamps2018-29862881,
  author  = {Barbero-Camps, E. and Roca-Agujetas, V. and Bartolessis, I. and de Dios, C. and Fernández-Checa, J. C. and Marí, M. and Morales, A. and Hartmann, T. and others},
  title   = {{Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion}},
  journal = {Autophagy},
  year    = {2018},
  doi     = {10.1080/15548627.2018.1438807},
  pmid    = {29862881},
  url     = {https://doi.org/10.1080/15548627.2018.1438807}
}

@article{hemming2007-17760499,
  author  = {Hemming, M. L. and Patterson, M. and Reske-Nielsen, C. and Lin, L. and Isacson, O. and Selkoe, D. J.},
  title   = {{Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease}},
  journal = {PLoS medicine},
  year    = {2007},
  doi     = {10.1371/journal.pmed.0040262},
  pmid    = {17760499},
  url     = {https://doi.org/10.1371/journal.pmed.0040262}
}

@article{rocaagujetas2021-33685483,
  author  = {Roca-Agujetas, V. and Barbero-Camps, E. and de Dios, C. and Podlesniy, P. and Abadin, X. and Morales, A. and Marí, M. and Trullàs, R. and others},
  title   = {{Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00435-6},
  pmid    = {33685483},
  url     = {https://doi.org/10.1186/s13024-021-00435-6}
}

@article{liao2017-27922847,
  author  = {Liao, F. and Yoon, H. and Kim, J.},
  title   = {{Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease}},
  journal = {Current opinion in lipidology},
  year    = {2017},
  doi     = {10.1097/mol.0000000000000383},
  pmid    = {27922847},
  url     = {https://doi.org/10.1097/mol.0000000000000383}
}

@article{cohn2021-34925024,
  author  = {Cohn, W. and Melnik, M. and Huang, C. and Teter, B. and Chandra, S. and Zhu, C. and McIntire, L. B. and John, V. and others},
  title   = {{Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.766082},
  pmid    = {34925024},
  url     = {https://doi.org/10.3389/fphar.2021.766082}
}

@article{benitez2021-34266459,
  author  = {Benitez, D. P. and Jiang, S. and Wood, J. and Wang, R. and Hall, C. M. and Peerboom, C. and Wong, N. and Stringer, K. M. and others},
  title   = {{Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00457-0},
  pmid    = {34266459},
  url     = {https://doi.org/10.1186/s13024-021-00457-0}
}

@article{hauremirande2019-30283032,
  author  = {Haure-Mirande, J. V. and Wang, M. and Audrain, M. and Fanutza, T. and Kim, S. H. and Heja, S. and Readhead, B. and Dudley, J. T. and others},
  title   = {{Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden}},
  journal = {Molecular psychiatry},
  year    = {2019},
  doi     = {10.1038/s41380-018-0255-6},
  pmid    = {30283032},
  url     = {https://doi.org/10.1038/s41380-018-0255-6}
}

@article{uhlmann2020-33199898,
  author  = {Uhlmann, R. E. and Rother, C. and Rasmussen, J. and Schelle, J. and Bergmann, C. and Ullrich Gavilanes, E. M. and Fritschi, S. K. and Buehler, A. and others},
  title   = {{Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life}},
  journal = {Nature neuroscience},
  year    = {2020},
  doi     = {10.1038/s41593-020-00737-w},
  pmid    = {33199898},
  url     = {https://doi.org/10.1038/s41593-020-00737-w}
}

@article{weller2008-18363936,
  author  = {Weller, R. O. and Subash, M. and Preston, S. D. and Mazanti, I. and Carare, R. O.},
  title   = {{Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2008},
  doi     = {10.1111/j.1750-3639.2008.00133.x},
  pmid    = {18363936},
  url     = {https://doi.org/10.1111/j.1750-3639.2008.00133.x}
}

@article{hanslik2020-33071950,
  author  = {Hanslik, K. L. and Ulland, T. K.},
  title   = {{The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease}},
  journal = {Frontiers in neurology},
  year    = {2020},
  doi     = {10.3389/fneur.2020.570711},
  pmid    = {33071950},
  url     = {https://doi.org/10.3389/fneur.2020.570711}
}

@article{gonzalezreyes2017-29311817,
  author  = {González-Reyes, R. E. and Nava-Mesa, M. O. and Vargas-Sánchez, K. and Ariza-Salamanca, D. and Mora-Muñoz, L.},
  title   = {{Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2017},
  doi     = {10.3389/fnmol.2017.00427},
  pmid    = {29311817},
  url     = {https://doi.org/10.3389/fnmol.2017.00427}
}

@article{megur2020-33374235,
  author  = {Megur, A. and Baltriukienė, D. and Bukelskienė, V. and Burokas, A.},
  title   = {{The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?}},
  journal = {Nutrients},
  year    = {2020},
  doi     = {10.3390/nu13010037},
  pmid    = {33374235},
  url     = {https://doi.org/10.3390/nu13010037}
}

@article{paudel2020-32046119,
  author  = {Paudel, Y. N. and Angelopoulou, E. and Piperi, C. and Othman, I. and Aamir, K. and Shaikh, M. F.},
  title   = {{Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9020383},
  pmid    = {32046119},
  url     = {https://doi.org/10.3390/cells9020383}
}

@article{kenkhuis2021-33597025,
  author  = {Kenkhuis, B. and Somarakis, A. and de Haan, L. and Dzyubachyk, O. and IJsselsteijn, M. E. and de Miranda, N. F. C. C. and Lelieveldt, B. P. F. and Dijkstra, J. and others},
  title   = {{Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients}},
  journal = {Acta neuropathologica communications},
  year    = {2021},
  doi     = {10.1186/s40478-021-01126-5},
  pmid    = {33597025},
  url     = {https://doi.org/10.1186/s40478-021-01126-5}
}

@article{alvarezsanchez2025-40348819,
  author  = {Álvarez‐Sánchez, Lourdes and Peña‐Bautista, Carmen and Ferré‐González, Laura and Balaguer, Ángel and Amengual, Julián Luis and Baquero, Miguel and Cháfer‐Pericás, Consuelo},
  title   = {{Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-01511-3},
  pmid    = {40348819},
  url     = {https://doi.org/10.1038/s41598-025-01511-3}
}

@article{zhang2025-41404739,
  author  = {Zhang, Chong‐Hui and Huang, Liang‐Yu and Feng, Yu‐Gong and Tan, Chen‐Chen and Tan, Lan and Xu, Wei},
  title   = {{APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms}},
  journal = {Journal of the American Heart Association},
  year    = {2025},
  doi     = {10.1161/jaha.125.043446},
  pmid    = {41404739},
  url     = {https://doi.org/10.1161/jaha.125.043446}
}

@article{acostauribe2026-41586258,
  author  = {Acosta‐Uribe, Juliana and Piña‐Escudero, Stefanie Danielle and Cochran, J. Nicholas and Taylor, Jared W. and Castruita, P. Alejandra and Jonson, Caroline and Barinaga, Erin A. and Roberts, Kevin and others},
  title   = {{Genetic contributions to Alzheimer’s disease and frontotemporal dementia in admixed Latin American populations}},
  journal = {npj Dementia},
  year    = {2026},
  doi     = {10.1038/s44400-025-00025-z},
  pmid    = {41586258},
  url     = {https://doi.org/10.1038/s44400-025-00025-z}
}

@article{rodriguezvieitez2015-25893384,
  author  = {Rodriguez-Vieitez, E. and Ni, R. and Gulyás, B. and Tóth, M. and Häggkvist, J. and Halldin, C. and Voytenko, L. and Marutle, A. and others},
  title   = {{Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2015},
  doi     = {10.1007/s00259-015-3047-0},
  pmid    = {25893384},
  url     = {https://doi.org/10.1007/s00259-015-3047-0}
}

@article{koldamova2005-16207713,
  author  = {Koldamova, R. and Staufenbiel, M. and Lefterov, I.},
  title   = {{Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m504513200},
  pmid    = {16207713},
  url     = {https://doi.org/10.1074/jbc.m504513200}
}

@article{zlokovic2013-23400708,
  author  = {Zlokovic, B. V.},
  title   = {{Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.2152},
  pmid    = {23400708},
  url     = {https://doi.org/10.1001/jamaneurol.2013.2152}
}

@article{hirschreinshagen2005-16207707,
  author  = {Hirsch-Reinshagen, V. and Maia, L. F. and Burgess, B. L. and Blain, J. F. and Naus, K. E. and McIsaac, S. A. and Parkinson, P. F. and Chan, J. Y. and others},
  title   = {{The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508781200},
  pmid    = {16207707},
  url     = {https://doi.org/10.1074/jbc.m508781200}
}

@article{li2012-23132858,
  author  = {Li, J. and Kanekiyo, T. and Shinohara, M. and Zhang, Y. and LaDu, M. J. and Xu, H. and Bu, G.},
  title   = {{Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.420224},
  pmid    = {23132858},
  url     = {https://doi.org/10.1074/jbc.m112.420224}
}