% alzhub.org library filter % Source: https://alzhub.org/research?access=free&about=treatments % 500 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{salloway2014-24450891, author = {Salloway, S. and Sperling, R. and Fox, N. C. and Blennow, K. and Klunk, W. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others}, title = {{Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2014}, doi = {10.1056/nejmoa1304839}, pmid = {24450891}, url = {https://doi.org/10.1056/nejmoa1304839} } @article{zimmer2025-40063015, author = {Zimmer, J. A. and Ardayfio, P. and Wang, H. and Khanna, R. and Evans, C. D. and Lu, M. and Sparks, J. and Andersen, S. and Lauzon, S. and Nery, E. S. M. and others}, title = {{Amyloid-Related Imaging Abnormalities With Donanemab in Early Symptomatic Alzheimer Disease: Secondary Analysis of the TRAILBLAZER-ALZ and ALZ 2 Randomized Clinical Trials}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.0065}, pmid = {40063015}, url = {https://doi.org/10.1001/jamaneurol.2025.0065} } @article{salloway2022-34807243, author = {Salloway, S. and Chalkias, S. and Barkhof, F. and Burkett, P. and Barakos, J. and Purcell, D. and Suhy, J. and Forrestal, F. and others}, title = {{Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2021.4161}, pmid = {34807243}, url = {https://doi.org/10.1001/jamaneurol.2021.4161} } @article{buddhaeberlein2022-35542991, author = {Budd Haeberlein, S. and Aisen, P. S. and Barkhof, F. and Chalkias, S. and Chen, T. and Cohen, S. and Dent, G. and Hansson, O. and others}, title = {{Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2022}, doi = {10.14283/jpad.2022.30}, pmid = {35542991}, url = {https://doi.org/10.14283/jpad.2022.30} } @article{pontecorvo2022-36251300, author = {Pontecorvo, M. J. and Lu, M. and Burnham, S. C. and Schade, A. E. and Dage, J. L. and Shcherbinin, S. and Collins, E. C. and Sims, JR. and others}, title = {{Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.3392}, pmid = {36251300}, url = {https://doi.org/10.1001/jamaneurol.2022.3392} } @article{swanson2021-33865446, author = {Swanson, C. J. and Zhang, Y. and Dhadda, S. and Wang, J. and Kaplow, J. and Lai, R. Y. K. and Lannfelt, L. and Bradley, H. and others}, title = {{A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00813-8}, pmid = {33865446}, url = {https://doi.org/10.1186/s13195-021-00813-8} } @article{cummings2025-39780249, author = {Cummings, J. L. and Atri, A. and Feldman, H. H. and Hansson, O. and Sano, M. and Knop, F. K. and Johannsen, P. and León, T. and others}, title = {{evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-024-01666-7}, pmid = {39780249}, url = {https://doi.org/10.1186/s13195-024-01666-7} } @article{green2009-20009055, author = {Green, R. C. and Schneider, L. S. and Amato, D. A. and Beelen, A. P. and Wilcock, G. and Swabb, E. A. and Zavitz, K. H. and {Tarenflurbil Phase 3 Study Group}}, title = {{Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial}}, journal = {JAMA}, year = {2009}, doi = {10.1001/jama.2009.1866}, pmid = {20009055}, url = {https://doi.org/10.1001/jama.2009.1866} } @article{mcshane2019-30891742, author = {McShane, R. and Westby, M. J. and Roberts, E. and Minakaran, N. and Schneider, L. and Farrimond, L. E. and Maayan, N. and Ware, J. and others}, title = {{Memantine for dementia}}, journal = {The Cochrane database of systematic reviews}, year = {2019}, doi = {10.1002/14651858.cd003154.pub6}, pmid = {30891742}, url = {https://doi.org/10.1002/14651858.cd003154.pub6} } @article{manson2013-24084921, author = {Manson, J. E. and Chlebowski, R. T. and Stefanick, M. L. and Aragaki, A. K. and Rossouw, J. E. and Prentice, R. L. and Anderson, G. and Howard, B. V. and others}, title = {{Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials}}, journal = {JAMA}, year = {2013}, doi = {10.1001/jama.2013.278040}, pmid = {24084921}, url = {https://doi.org/10.1001/jama.2013.278040} } @article{vandyck2023-36449413, author = {van Dyck, C. H. and Swanson, C. J. and Aisen, P. and Bateman, R. J. and Chen, C. and Gee, M. and Kanekiyo, M. and Li, D. and others}, title = {{Lecanemab in Early Alzheimer's Disease}}, journal = {The New England journal of medicine}, year = {2023}, doi = {10.1056/nejmoa2212948}, pmid = {36449413}, url = {https://doi.org/10.1056/nejmoa2212948} } @article{dysken2014-24381967, author = {Dysken, M. W. and Sano, M. and Asthana, S. and Vertrees, J. E. and Pallaki, M. and Llorente, M. and Love, S. and Schellenberg, G. D. and others}, title = {{Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial}}, journal = {JAMA}, year = {2014}, doi = {10.1001/jama.2013.282834}, pmid = {24381967}, url = {https://doi.org/10.1001/jama.2013.282834} } @article{howard2020-31738372, author = {Howard, R. and Zubko, O. and Bradley, R. and Harper, E. and Pank, L. and O'Brien, J. and Fox, C. and Tabet, N. and others}, title = {{Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2019.3762}, pmid = {31738372}, url = {https://doi.org/10.1001/jamaneurol.2019.3762} } @article{mintun2021-33720637, author = {Mintun, M. A. and Lo, A. C. and Duggan Evans, C. and Wessels, A. M. and Ardayfio, P. A. and Andersen, S. W. and Shcherbinin, S. and Sparks, J. and others}, title = {{Donanemab in Early Alzheimer's Disease}}, journal = {The New England journal of medicine}, year = {2021}, doi = {10.1056/nejmoa2100708}, pmid = {33720637}, url = {https://doi.org/10.1056/nejmoa2100708} } @article{birks2018-29923184, author = {Birks, J. S. and Harvey, R. J.}, title = {{Donepezil for dementia due to Alzheimer's disease}}, journal = {The Cochrane database of systematic reviews}, year = {2018}, doi = {10.1002/14651858.cd001190.pub3}, pmid = {29923184}, url = {https://doi.org/10.1002/14651858.cd001190.pub3} } @article{honig2024-38730496, author = {Honig, L. S. and Sabbagh, M. N. and van Dyck, C. H. and Sperling, R. A. and Hersch, S. and Matta, A. and Giorgi, L. and Gee, M. and others}, title = {{Updated safety results from phase 3 lecanemab study in early Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01441-8}, pmid = {38730496}, url = {https://doi.org/10.1186/s13195-024-01441-8} } @article{aisen2008-18854539, author = {Aisen, P. S. and Schneider, L. S. and Sano, M. and Diaz-Arrastia, R. and van Dyck, C. H. and Weiner, M. F. and Bottiglieri, T. and Jin, S. and others}, title = {{High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial}}, journal = {JAMA}, year = {2008}, doi = {10.1001/jama.300.15.1774}, pmid = {18854539}, url = {https://doi.org/10.1001/jama.300.15.1774} } @article{alves2023-36973044, author = {Alves, F. and Kalinowski, P. and Ayton, S.}, title = {{Accelerated Brain Volume Loss Caused by Anti-β-Amyloid Drugs: A Systematic Review and Meta-analysis}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207156}, pmid = {36973044}, url = {https://doi.org/10.1212/wnl.0000000000207156} } @article{wessels2020-31764959, author = {Wessels, A. M. and Tariot, P. N. and Zimmer, J. A. and Selzler, K. J. and Bragg, S. M. and Andersen, S. W. and Landry, J. and Krull, J. H. and others}, title = {{Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2019.3988}, pmid = {31764959}, url = {https://doi.org/10.1001/jamaneurol.2019.3988} } @article{teng2022-35696185, author = {Teng, E. and Manser, P. T. and Pickthorn, K. and Brunstein, F. and Blendstrup, M. and Sanabria Bohorquez, S. and Wildsmith, K. R. and Toth, B. and others}, title = {{Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.1375}, pmid = {35696185}, url = {https://doi.org/10.1001/jamaneurol.2022.1375} } @article{atri2018-29318278, author = {Atri, A. and Frölich, L. and Ballard, C. and Tariot, P. N. and Molinuevo, J. L. and Boneva, N. and Windfeld, K. and Raket, L. L. and others}, title = {{Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials}}, journal = {JAMA}, year = {2018}, doi = {10.1001/jama.2017.20373}, pmid = {29318278}, url = {https://doi.org/10.1001/jama.2017.20373} } @article{emre2004-15590953, author = {Emre, M. and Aarsland, D. and Albanese, A. and Byrne, E. J. and Deuschl, G. and De Deyn, P. P. and Durif, F. and Kulisevsky, J. and others}, title = {{Rivastigmine for dementia associated with Parkinson's disease}}, journal = {The New England journal of medicine}, year = {2004}, doi = {10.1056/nejmoa041470}, pmid = {15590953}, url = {https://doi.org/10.1056/nejmoa041470} } @article{ostrowitzki2017-29221491, author = {Ostrowitzki, S. and Lasser, R. A. and Dorflinger, E. and Scheltens, P. and Barkhof, F. and Nikolcheva, T. and Ashford, E. and Retout, S. and others}, title = {{A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2017}, doi = {10.1186/s13195-017-0318-y}, pmid = {29221491}, url = {https://doi.org/10.1186/s13195-017-0318-y} } @article{craft2020-32568367, author = {Craft, S. and Raman, R. and Chow, T. W. and Rafii, M. S. and Sun, C. K. and Rissman, R. A. and Donohue, M. C. and Brewer, J. B. and others}, title = {{Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.1840}, pmid = {32568367}, url = {https://doi.org/10.1001/jamaneurol.2020.1840} } @article{tzourio2003-12742805, author = {Tzourio, C. and Anderson, C. and Chapman, N. and Woodward, M. and Neal, B. and MacMahon, S. and Chalmers, J. and {PROGRESS Collaborative Group}}, title = {{Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease}}, journal = {Archives of internal medicine}, year = {2003}, doi = {10.1001/archinte.163.9.1069}, pmid = {12742805}, url = {https://doi.org/10.1001/archinte.163.9.1069} } @article{battle2021-33704781, author = {Battle, C. E. and Abdul-Rahim, A. H. and Shenkin, S. D. and Hewitt, J. and Quinn, T. J.}, title = {{Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta-analysis}}, journal = {The Cochrane database of systematic reviews}, year = {2021}, doi = {10.1002/14651858.cd013306.pub2}, pmid = {33704781}, url = {https://doi.org/10.1002/14651858.cd013306.pub2} } @article{mok2024-38631737, author = {Mok, P. L. H. and Carr, M. J. and Guthrie, B. and Morales, D. R. and Sheikh, A. and Elliott, R. A. and Camacho, E. M. and van Staa, T. and Avery, A. J. and Ashcroft, D. M.}, title = {{Multiple adverse outcomes associated with antipsychotic use in people with dementia: population based matched cohort study}}, journal = {BMJ}, year = {2024}, doi = {10.1136/bmj-2023-076268}, pmid = {38631737}, url = {https://doi.org/10.1136/bmj-2023-076268} } @article{wang2025-40172303, author = {Wang, H. and Serap Monkul Nery, E. and Ardayfio, P. and Khanna, R. and Otero Svaldi, D. and Gueorguieva, I. and Shcherbinin, S. and Andersen, S. W. and Hauck, P. M. and Engle, S. E. and others}, title = {{Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70062}, pmid = {40172303}, url = {https://doi.org/10.1002/alz.70062} } @article{nonino2026-41985900, author = {Nonino, F. and Minozzi, S. and Sambati, L. and Del Giovane, C. and Baldin, E. and Bassi, M. C. and others}, title = {{Amyloid-beta-targeting monoclonal antibodies for people with mild cognitive impairment or mild dementia due to Alzheimer's disease (Cochrane review)}}, journal = {Cochrane Database of Systematic Reviews}, year = {2026}, doi = {10.1002/14651858.CD016297}, pmid = {41985900}, url = {https://doi.org/10.1002/14651858.CD016297} } @article{lu2025-41082199, author = {Lu, M. and Kim, M. J. and Collins, E. C. and Shcherbinin, S. and Ellinwood, A. K. and Yokoi, Y. and Brooks, D. A. and Hansson, O. and others}, title = {{Posttreatment Amyloid Levels and Clinical Outcomes Following Donanemab for Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ 2 Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.3869}, pmid = {41082199}, url = {https://doi.org/10.1001/jamaneurol.2025.3869} } @article{shcherbinin2022-36094645, author = {Shcherbinin, S. and Evans, C. D. and Lu, M. and Andersen, S. W. and Pontecorvo, M. J. and Willis, B. A. and Gueorguieva, I. and Hauck, P. M. and others}, title = {{Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.2793}, pmid = {36094645}, url = {https://doi.org/10.1001/jamaneurol.2022.2793} } @article{shanks2024-38760589, author = {Shanks, H. R. C. and Chen, K. and Reiman, E. M. and Blennow, K. and Cummings, J. L. and Massa, S. M. and Longo, F. M. and Börjesson-Hanson, A. and others}, title = {{p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-02977-w}, pmid = {38760589}, url = {https://doi.org/10.1038/s41591-024-02977-w} } @article{adesuyan2024-38324745, author = {Adesuyan, M. and Jani, Y. H. and Alsugeir, D. and Howard, R. and Ju, C. and Wei, L. and Brauer, R.}, title = {{Phosphodiesterase Type 5 Inhibitors in Men With Erectile Dysfunction and the Risk of Alzheimer Disease: A Cohort Study}}, journal = {Neurology}, year = {2024}, doi = {10.1212/wnl.0000000000209131}, pmid = {38324745}, url = {https://doi.org/10.1212/wnl.0000000000209131} } @article{peters2008-18614402, author = {Peters, R. and Beckett, N. and Forette, F. and Tuomilehto, J. and Clarke, R. and Ritchie, C. and Waldman, A. and Walton, I. and others}, title = {{Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial}}, journal = {The Lancet. Neurology}, year = {2008}, doi = {10.1016/s1474-4422(08)70143-1}, pmid = {18614402}, url = {https://doi.org/10.1016/s1474-4422(08)70143-1} } @article{graff2006-17114212, author = {Graff, M. J. and Vernooij-Dassen, M. J. and Thijssen, M. and Dekker, J. and Hoefnagels, W. H. and Rikkert, M. G.}, title = {{Community based occupational therapy for patients with dementia and their care givers: randomised controlled trial}}, journal = {BMJ (Clinical research ed.)}, year = {2006}, doi = {10.1136/bmj.39001.688843.be}, pmid = {17114212}, url = {https://doi.org/10.1136/bmj.39001.688843.be} } @article{forette2002-12374512, author = {Forette, F. and Seux, M. L. and Staessen, J. A. and Thijs, L. and Babarskiene, M. R. and Babeanu, S. and Bossini, A. and Fagard, R. and others}, title = {{The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study}}, journal = {Archives of internal medicine}, year = {2002}, doi = {10.1001/archinte.162.18.2046}, pmid = {12374512}, url = {https://doi.org/10.1001/archinte.162.18.2046} } @article{sano2011-21795660, author = {Sano, M. and Bell, K. L. and Galasko, D. and Galvin, J. E. and Thomas, R. G. and van Dyck, C. H. and Aisen, P. S.}, title = {{A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e318228bf11}, pmid = {21795660}, url = {https://doi.org/10.1212/wnl.0b013e318228bf11} } @article{woods2018-29493789, author = {Woods, B. and O'Philbin, L. and Farrell, E. M. and Spector, A. E. and Orrell, M.}, title = {{Reminiscence therapy for dementia}}, journal = {The Cochrane database of systematic reviews}, year = {2018}, doi = {10.1002/14651858.cd001120.pub3}, pmid = {29493789}, url = {https://doi.org/10.1002/14651858.cd001120.pub3} } @article{ebell2024-38253509, author = {Ebell, M. H. and Barry, H. C. and Baduni, K. and Grasso, G.}, title = {{Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis}}, journal = {Annals of Family Medicine}, year = {2024}, doi = {10.1370/afm.3050}, pmid = {38253509}, url = {https://doi.org/10.1370/afm.3050} } @article{barthelemy2024-38382645, author = {Barthélemy, N. R. and Salvadó, G. and Schindler, S. E. and He, Y. and Janelidze, S. and Collij, L. E. and Saef, B. and Henson, R. L. and others}, title = {{Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-02869-z}, pmid = {38382645}, url = {https://doi.org/10.1038/s41591-024-02869-z} } @article{wagemann2024-38683602, author = {Wagemann, O. and Liu, H. and Wang, G. and Shi, X. and Bittner, T. and Scelsi, M. A. and Farlow, M. R. and Clifford, D. B. and others}, title = {{Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.0991}, pmid = {38683602}, url = {https://doi.org/10.1001/jamaneurol.2024.0991} } @article{salloway2009-19923550, author = {Salloway, S. and Sperling, R. and Gilman, S. and Fox, N. C. and Blennow, K. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others}, title = {{A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181c67808}, pmid = {19923550}, url = {https://doi.org/10.1212/wnl.0b013e3181c67808} } @article{sims2023-37459141, author = {Sims, JR. and Zimmer, J. A. and Evans, C. D. and Lu, M. and Ardayfio, P. and Sparks, J. and Wessels, A. M. and Shcherbinin, S. and others}, title = {{Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial}}, journal = {JAMA}, year = {2023}, doi = {10.1001/jama.2023.13239}, pmid = {37459141}, url = {https://doi.org/10.1001/jama.2023.13239} } @article{craft2012-21911655, author = {Craft, S. and Baker, L. D. and Montine, T. J. and Minoshima, S. and Watson, G. S. and Claxton, A. and Arbuckle, M. and Callaghan, M. and others}, title = {{Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial}}, journal = {Archives of neurology}, year = {2012}, doi = {10.1001/archneurol.2011.233}, pmid = {21911655}, url = {https://doi.org/10.1001/archneurol.2011.233} } @article{aisen2011-22291741, author = {Aisen, P. S. and Gauthier, S. and Ferris, S. H. and Saumier, D. and Haine, D. and Garceau, D. and Duong, A. and Suhy, J. and others}, title = {{Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)}}, journal = {Archives of medical science : AMS}, year = {2011}, doi = {10.5114/aoms.2011.20612}, pmid = {22291741}, url = {https://doi.org/10.5114/aoms.2011.20612} } @article{monteiro2023-37643887, author = {Monteiro, C. and Toth, B. and Brunstein, F. and Bobbala, A. and Datta, S. and Ceniceros, R. and Sanabria Bohorquez, S. M. and Anania, V. G. and others}, title = {{Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207663}, pmid = {37643887}, url = {https://doi.org/10.1212/wnl.0000000000207663} } @article{seminer2025-40193122, author = {Seminer, A. and Mulihano, A. and O'Brien, C. and Krewer, F. and Costello, M. and Judge, C. and O'Donnell, M. and Reddin, C.}, title = {{Cardioprotective Glucose-Lowering Agents and Dementia Risk: A Systematic Review and Meta-Analysis}}, journal = {JAMA neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.0360}, pmid = {40193122}, url = {https://doi.org/10.1001/jamaneurol.2025.0360} } @article{petersen2018-29282327, author = {Petersen, R. C. and Lopez, O. and Armstrong, M. J. and Getchius, T. S. D. and Ganguli, M. and Gloss, D. and Gronseth, G. S. and Marson, D. and others}, title = {{Practice guideline update summary: Mild cognitive impairment [RETIRED]: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000004826}, pmid = {29282327}, url = {https://doi.org/10.1212/wnl.0000000000004826} } @article{ding2020-31706889, author = {Ding, J. and Davis-Plourde, K. L. and Sedaghat, S. and Tully, P. J. and Wang, W. and Phillips, C. and Pase, M. P. and Himali, J. J. and others}, title = {{Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies}}, journal = {The Lancet. Neurology}, year = {2020}, doi = {10.1016/s1474-4422(19)30393-x}, pmid = {31706889}, url = {https://doi.org/10.1016/s1474-4422(19)30393-x} } @article{coupland2019-31233095, author = {Coupland, C. A. C. and Hill, T. and Dening, T. and Morriss, R. and Moore, M. and Hippisley-Cox, J.}, title = {{Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study}}, journal = {JAMA internal medicine}, year = {2019}, doi = {10.1001/jamainternmed.2019.0677}, pmid = {31233095}, url = {https://doi.org/10.1001/jamainternmed.2019.0677} } @article{thyrian2017-28746708, author = {Thyrian, JR. and Hertel, J. and Wucherer, D. and Eichler, T. and Michalowsky, B. and Dreier-Wolfgramm, A. and Zwingmann, I. and Kilimann, I. and others}, title = {{Effectiveness and Safety of Dementia Care Management in Primary Care: A Randomized Clinical Trial}}, journal = {JAMA psychiatry}, year = {2017}, doi = {10.1001/jamapsychiatry.2017.2124}, pmid = {28746708}, url = {https://doi.org/10.1001/jamapsychiatry.2017.2124} } @article{huang2021-33428867, author = {Huang, C. and Huang, L. and Wang, Y. and Li, X. and Ren, L. and Gu, X. and Kang, L. and Guo, L. and others}, title = {{6-month consequences of COVID-19 in patients discharged from hospital: a cohort study}}, journal = {Lancet (London, England)}, year = {2021}, doi = {10.1016/s0140-6736(20)32656-8}, pmid = {33428867}, url = {https://doi.org/10.1016/s0140-6736(20)32656-8} } @article{intveld2001-11794217, author = {in t' Veld, B. A. and Ruitenberg, A. and Hofman, A. and Launer, L. J. and van Duijn, C. M. and Stijnen, T. and Breteler, M. M. and Stricker, B. H.}, title = {{Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2001}, doi = {10.1056/nejmoa010178}, pmid = {11794217}, url = {https://doi.org/10.1056/nejmoa010178} } @article{douaud2013-23690582, author = {Douaud, G. and Refsum, H. and de Jager, C. A. and Jacoby, R. and Nichols, T. E. and Smith, S. M. and Smith, A. D.}, title = {{Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2013}, doi = {10.1073/pnas.1301816110}, pmid = {23690582}, url = {https://doi.org/10.1073/pnas.1301816110} } @article{rolinski2012-22419314, author = {Rolinski, M. and Fox, C. and Maidment, I. and McShane, R.}, title = {{Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease}}, journal = {The Cochrane database of systematic reviews}, year = {2012}, doi = {10.1002/14651858.cd006504.pub2}, pmid = {22419314}, url = {https://doi.org/10.1002/14651858.cd006504.pub2} } @article{prins2021-34044875, author = {Prins, N. D. and Harrison, J. E. and Chu, H. M. and Blackburn, K. and Alam, J. J. and Scheltens, P. and {REVERSE-SD Study Investigators}}, title = {{A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00843-2}, pmid = {34044875}, url = {https://doi.org/10.1186/s13195-021-00843-2} } @article{vandersteen2025-40049590, author = {van der Steen, J. T. and van der Wouden, J. C. and Methley, A. M. and Smaling, H. J. A. and Vink, A. C. and Bruinsma, M. S.}, title = {{Music-based therapeutic interventions for people with dementia (Cochrane review update)}}, journal = {Cochrane Database of Systematic Reviews}, year = {2025}, doi = {10.1002/14651858.CD003477.pub5}, pmid = {40049590}, url = {https://doi.org/10.1002/14651858.CD003477.pub5} } @article{breitner2011-21784351, author = {Breitner, J. C. and Baker, L. D. and Montine, T. J. and Meinert, C. L. and Lyketsos, C. G. and Ashe, K. H. and Brandt, J. and Craft, S. and others}, title = {{Extended results of the Alzheimer's disease anti-inflammatory prevention trial}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2011}, doi = {10.1016/j.jalz.2010.12.014}, pmid = {21784351}, url = {https://doi.org/10.1016/j.jalz.2010.12.014} } @article{tsai2020-31710340, author = {Tsai, R. M. and Miller, Z. and Koestler, M. and Rojas, J. C. and Ljubenkov, P. A. and Rosen, H. J. and Rabinovici, G. D. and Fagan, A. M. and others}, title = {{Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2019.3812}, pmid = {31710340}, url = {https://doi.org/10.1001/jamaneurol.2019.3812} } @article{sperling2021-33464300, author = {Sperling, R. and Henley, D. and Aisen, P. S. and Raman, R. and Donohue, M. C. and Ernstrom, K. and Rafii, M. S. and Streffer, J. and others}, title = {{Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial}}, journal = {JAMA neurology}, year = {2021}, doi = {10.1001/jamaneurol.2020.4857}, pmid = {33464300}, url = {https://doi.org/10.1001/jamaneurol.2020.4857} } @article{truong2022-36096687, author = {Truong, C. and Recto, C. and Lafont, C. and Canoui-Poitrine, F. and Belmin, J. B. and Lafuente-Lafuente, C.}, title = {{Effect of Cholinesterase Inhibitors on Mortality in Patients With Dementia: A Systematic Review of Randomized and Nonrandomized Trials}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201161}, pmid = {36096687}, url = {https://doi.org/10.1212/wnl.0000000000201161} } @article{spector2003-12948999, author = {Spector, A. and Thorgrimsen, L. and Woods, B. and Royan, L. and Davies, S. and Butterworth, M. and Orrell, M.}, title = {{Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial}}, journal = {The British journal of psychiatry : the journal of mental science}, year = {2003}, doi = {10.1192/bjp.183.3.248}, pmid = {12948999}, url = {https://doi.org/10.1192/bjp.183.3.248} } @article{galasko2012-22431837, author = {Galasko, D. R. and Peskind, E. and Clark, C. M. and Quinn, J. F. and Ringman, J. M. and Jicha, G. A. and Cotman, C. and Cottrell, B. and others}, title = {{Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures}}, journal = {Archives of neurology}, year = {2012}, doi = {10.1001/archneurol.2012.85}, pmid = {22431837}, url = {https://doi.org/10.1001/archneurol.2012.85} } @article{martinkova2021-34515784, author = {Martinkova, J. and Quevenco, F. C. and Karcher, H. and Ferrari, A. and Sandset, E. C. and Szoeke, C. and Hort, J. and Schmidt, R. and others}, title = {{Proportion of Women and Reporting of Outcomes by Sex in Clinical Trials for Alzheimer Disease: A Systematic Review and Meta-analysis}}, journal = {JAMA network open}, year = {2021}, doi = {10.1001/jamanetworkopen.2021.24124}, pmid = {34515784}, url = {https://doi.org/10.1001/jamanetworkopen.2021.24124} } @article{mori2012-22829268, author = {Mori, E. and Ikeda, M. and Kosaka, K. and {Donepezil-DLB Study Investigators}}, title = {{Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial}}, journal = {Annals of neurology}, year = {2012}, doi = {10.1002/ana.23557}, pmid = {22829268}, url = {https://doi.org/10.1002/ana.23557} } @article{wang2005-16319382, author = {Wang, P. S. and Schneeweiss, S. and Avorn, J. and Fischer, M. A. and Mogun, H. and Solomon, D. H. and Brookhart, M. A.}, title = {{Risk of death in elderly users of conventional vs. atypical antipsychotic medications}}, journal = {The New England journal of medicine}, year = {2005}, doi = {10.1056/nejmoa052827}, pmid = {16319382}, url = {https://doi.org/10.1056/nejmoa052827} } @article{russ2012-22972133, author = {Russ, T. C. and Morling, JR.}, title = {{Cholinesterase inhibitors for mild cognitive impairment}}, journal = {The Cochrane database of systematic reviews}, year = {2012}, doi = {10.1002/14651858.cd009132.pub2}, pmid = {22972133}, url = {https://doi.org/10.1002/14651858.cd009132.pub2} } @article{birks2006-16437532, author = {Birks, J.}, title = {{Cholinesterase inhibitors for Alzheimer's disease}}, journal = {The Cochrane database of systematic reviews}, year = {2006}, doi = {10.1002/14651858.cd005593}, pmid = {16437532}, url = {https://doi.org/10.1002/14651858.cd005593} } @article{wischik2015-25550228, author = {Wischik, C. M. and Staff, R. T. and Wischik, D. J. and Bentham, P. and Murray, A. D. and Storey, J. M. and Kook, K. A. and Harrington, C. R.}, title = {{Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's disease}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2015}, doi = {10.3233/jad-142874}, pmid = {25550228}, url = {https://doi.org/10.3233/jad-142874} } @article{loy2006-16437436, author = {Loy, C. and Schneider, L.}, title = {{Galantamine for Alzheimer's disease and mild cognitive impairment}}, journal = {The Cochrane database of systematic reviews}, year = {2006}, doi = {10.1002/14651858.cd001747.pub3}, pmid = {16437436}, url = {https://doi.org/10.1002/14651858.cd001747.pub3} } @article{cummings2026-41865758, author = {Cummings, Jeffrey L and Atri, Alireza and Sano, Mary and Zetterberg, Henrik and Scheltens, Philip and Knop, Filip K and Johannsen, Peter and Wichmann, Christian Ahmad and others}, title = {{Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials}}, journal = {The Lancet}, year = {2026}, doi = {10.1016/s0140-6736(26)00459-9}, pmid = {41865758}, url = {https://doi.org/10.1016/s0140-6736(26)00459-9} } @article{paczynski2025-40354064, author = {Paczynski, M. and Hofmann, A. and Posey, Z. and Gregersen, M. and Rudman, M. and Ellington, D. and Aldinger, M. and Musiek, E. S. and Holtzman, D. M. and Bateman, R. J. and others}, title = {{Lecanemab Treatment in a Specialty Memory Clinic}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.1232}, pmid = {40354064}, url = {https://doi.org/10.1001/jamaneurol.2025.1232} } @article{rosenberg2010-20087081, author = {Rosenberg, P. B. and Drye, L. T. and Martin, B. K. and Frangakis, C. and Mintzer, J. E. and Weintraub, D. and Porsteinsson, A. P. and Schneider, L. S. and others}, title = {{Sertraline for the treatment of depression in Alzheimer disease}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2010}, doi = {10.1097/jgp.0b013e3181c796eb}, pmid = {20087081}, url = {https://doi.org/10.1097/jgp.0b013e3181c796eb} } @article{tariot2011-21810649, author = {Tariot, P. N. and Schneider, L. S. and Cummings, J. and Thomas, R. G. and Raman, R. and Jakimovich, L. J. and Loy, R. and Bartocci, B. and others}, title = {{Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease}}, journal = {Archives of general psychiatry}, year = {2011}, doi = {10.1001/archgenpsychiatry.2011.72}, pmid = {21810649}, url = {https://doi.org/10.1001/archgenpsychiatry.2011.72} } @article{watt2021-33637039, author = {Watt, J. A. and Veroniki, A. A. and Tricco, A. C. and Straus, S. E.}, title = {{Using a distribution-based approach and systematic review methods to derive minimum clinically important differences}}, journal = {BMC medical research methodology}, year = {2021}, doi = {10.1186/s12874-021-01228-7}, pmid = {33637039}, url = {https://doi.org/10.1186/s12874-021-01228-7} } @article{maier2020-32463470, author = {Maier, F. and Spottke, A. and Bach, J. P. and Bartels, C. and Buerger, K. and Dodel, R. and Fellgiebel, A. and Fliessbach, K. and others}, title = {{Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2020}, doi = {10.1001/jamanetworkopen.2020.6027}, pmid = {32463470}, url = {https://doi.org/10.1001/jamanetworkopen.2020.6027} } @article{alam2023-37657939, author = {Alam, J. J. and Maruff, P. and Doctrow, SR. and Chu, H. M. and Conway, J. and Gomperts, S. N. and Teunissen, C.}, title = {{Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207755}, pmid = {37657939}, url = {https://doi.org/10.1212/wnl.0000000000207755} } @article{singh2024-39432286, author = {Singh, S. and Li, X. and Cocoros, N. M. and Antonelli, M. T. and Avula, R. and Crawford, S. L. and Dashevsky, I. and Fouayzi, H. and others}, title = {{High-Risk Medications in Persons Living With Dementia: A Randomized Clinical Trial}}, journal = {JAMA internal medicine}, year = {2024}, doi = {10.1001/jamainternmed.2024.5632}, pmid = {39432286}, url = {https://doi.org/10.1001/jamainternmed.2024.5632} } @article{richardson2018-29695481, author = {Richardson, K. and Fox, C. and Maidment, I. and Steel, N. and Loke, Y. K. and Arthur, A. and Myint, P. K. and Grossi, C. M. and others}, title = {{Anticholinergic drugs and risk of dementia: case-control study}}, journal = {BMJ (Clinical research ed.)}, year = {2018}, doi = {10.1136/bmj.k1315}, pmid = {29695481}, url = {https://doi.org/10.1136/bmj.k1315} } @article{seppi2011-22021174, author = {Seppi, K. and Weintraub, D. and Coelho, M. and Perez-Lloret, S. and Fox, S. H. and Katzenschlager, R. and Hametner, E. M. and Poewe, W. and others}, title = {{The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2011}, doi = {10.1002/mds.23884}, pmid = {22021174}, url = {https://doi.org/10.1002/mds.23884} } @article{orrell2017-28350796, author = {Orrell, M. and Yates, L. and Leung, P. and Kang, S. and Hoare, Z. and Whitaker, C. and Burns, A. and others}, title = {{The impact of individual Cognitive Stimulation Therapy (iCST) on cognition, quality of life, caregiver health, and family relationships in dementia: A randomised controlled trial}}, journal = {PLoS medicine}, year = {2017}, doi = {10.1371/journal.pmed.1002269}, pmid = {28350796}, url = {https://doi.org/10.1371/journal.pmed.1002269} } @article{sevigny2024-38745011, author = {Sevigny, J. and Uspenskaya, O. and Heckman, L. D. and Wong, L. C. and Hatch, D. A. and Tewari, A. and Vandenberghe, R. and Irwin, D. J. and others}, title = {{Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-02973-0}, pmid = {38745011}, url = {https://doi.org/10.1038/s41591-024-02973-0} } @article{gomm2016-26882076, author = {Gomm, W. and von Holt, K. and Thomé, F. and Broich, K. and Maier, W. and Fink, A. and Doblhammer, G. and Haenisch, B.}, title = {{Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2015.4791}, pmid = {26882076}, url = {https://doi.org/10.1001/jamaneurol.2015.4791} } @article{vickers2007-17626056, author = {Vickers, M. R. and MacLennan, A. H. and Lawton, B. and Ford, D. and Martin, J. and Meredith, S. K. and DeStavola, B. L. and Rose, S. and others}, title = {{Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women}}, journal = {BMJ (Clinical research ed.)}, year = {2007}, doi = {10.1136/bmj.39266.425069.ad}, pmid = {17626056}, url = {https://doi.org/10.1136/bmj.39266.425069.ad} } @article{ancelin2006-16452102, author = {Ancelin, M. L. and Artero, S. and Portet, F. and Dupuy, A. M. and Touchon, J. and Ritchie, K.}, title = {{Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study}}, journal = {BMJ (Clinical research ed.)}, year = {2006}, doi = {10.1136/bmj.38740.439664.de}, pmid = {16452102}, url = {https://doi.org/10.1136/bmj.38740.439664.de} } @article{hippisleycox2010-20488911, author = {Hippisley-Cox, J. and Coupland, C.}, title = {{Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database}}, journal = {BMJ (Clinical research ed.)}, year = {2010}, doi = {10.1136/bmj.c2197}, pmid = {20488911}, url = {https://doi.org/10.1136/bmj.c2197} } @article{reynolds2011-21199965, author = {Reynolds, C. F. and Butters, M. A. and Lopez, O. and Pollock, B. G. and Dew, M. A. and Mulsant, B. H. and Lenze, E. J. and Holm, M. and others}, title = {{Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy}}, journal = {Archives of general psychiatry}, year = {2011}, doi = {10.1001/archgenpsychiatry.2010.184}, pmid = {21199965}, url = {https://doi.org/10.1001/archgenpsychiatry.2010.184} } @article{schneider2014-24605808, author = {Schneider, L. S. and Mangialasche, F. and Andreasen, N. and Feldman, H. and Giacobini, E. and Jones, R. and Mantua, V. and Mecocci, P. and others}, title = {{Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014}}, journal = {Journal of internal medicine}, year = {2014}, doi = {10.1111/joim.12191}, pmid = {24605808}, url = {https://doi.org/10.1111/joim.12191} } @article{study2008-18474729, author = {{ADAPT Research Group} and Martin, B. K. and Szekely, C. and Brandt, J. and Piantadosi, S. and Breitner, J. C. and Craft, S. and Evans, D. and others}, title = {{Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib}}, journal = {Archives of neurology}, year = {2008}, doi = {10.1001/archneur.2008.65.7.nct70006}, pmid = {18474729}, url = {https://doi.org/10.1001/archneur.2008.65.7.nct70006} } @article{fleisher2008-18695053, author = {Fleisher, A. S. and Raman, R. and Siemers, E. R. and Becerra, L. and Clark, C. M. and Dean, R. A. and Farlow, M. R. and Galvin, J. E. and others}, title = {{Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease}}, journal = {Archives of neurology}, year = {2008}, doi = {10.1001/archneur.65.8.1031}, pmid = {18695053}, url = {https://doi.org/10.1001/archneur.65.8.1031} } @article{rafii2011-21502597, author = {Rafii, M. S. and Walsh, S. and Little, J. T. and Behan, K. and Reynolds, B. and Ward, C. and Jin, S. and Thomas, R. and others}, title = {{A phase II trial of huperzine A in mild to moderate Alzheimer disease}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e318216eb7b}, pmid = {21502597}, url = {https://doi.org/10.1212/wnl.0b013e318216eb7b} } @article{marcum2023-36598787, author = {Marcum, Z. A. and Gabriel, N. and Bress, A. P. and Hernandez, I.}, title = {{Association of New Use of Antihypertensives That Stimulate vs Inhibit Type 2 and 4 Angiotensin II Receptors With Dementia Among Medicare Beneficiaries}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2022.49370}, pmid = {36598787}, url = {https://doi.org/10.1001/jamanetworkopen.2022.49370} } @article{ahlskog2011-21878600, author = {Ahlskog, J. E. and Geda, Y. E. and Graff-Radford, N. R. and Petersen, R. C.}, title = {{Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging}}, journal = {Mayo Clinic proceedings}, year = {2011}, doi = {10.4065/mcp.2011.0252}, pmid = {21878600}, url = {https://doi.org/10.4065/mcp.2011.0252} } @article{koenig2017-28538088, author = {Koenig, A. M. and Mechanic-Hamilton, D. and Xie, S. X. and Combs, M. F. and Cappola, A. R. and Xie, L. and Detre, J. A. and Wolk, D. A. and others}, title = {{Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study}}, journal = {Alzheimer disease and associated disorders}, year = {2017}, doi = {10.1097/wad.0000000000000202}, pmid = {28538088}, url = {https://doi.org/10.1097/wad.0000000000000202} } @article{petersen2017-27716673, author = {Petersen, S. and Houston, S. and Qin, H. and Tague, C. and Studley, J.}, title = {{The Utilization of Robotic Pets in Dementia Care}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-160703}, pmid = {27716673}, url = {https://doi.org/10.3233/jad-160703} } @article{ornstein2020-32833020, author = {Ornstein, K. A. and Roth, D. L. and Huang, J. and Levitan, E. B. and Rhodes, J. D. and Fabius, C. D. and Safford, M. M. and Sheehan, O. C.}, title = {{Evaluation of Racial Disparities in Hospice Use and End-of-Life Treatment Intensity in the REGARDS Cohort}}, journal = {JAMA network open}, year = {2020}, doi = {10.1001/jamanetworkopen.2020.14639}, pmid = {32833020}, url = {https://doi.org/10.1001/jamanetworkopen.2020.14639} } @article{mervin2018-29325922, author = {Mervin, M. C. and Moyle, W. and Jones, C. and Murfield, J. and Draper, B. and Beattie, E. and Shum, D. H. K. and O'Dwyer, S. and others}, title = {{The Cost-Effectiveness of Using PARO, a Therapeutic Robotic Seal, to Reduce Agitation and Medication Use in Dementia: Findings from a Cluster-Randomized Controlled Trial}}, journal = {Journal of the American Medical Directors Association}, year = {2018}, doi = {10.1016/j.jamda.2017.10.008}, pmid = {29325922}, url = {https://doi.org/10.1016/j.jamda.2017.10.008} } @article{petersen2005-15829527, author = {Petersen, R. C. and Thomas, R. G. and Grundman, M. and Bennett, D. and Doody, R. and Ferris, S. and Galasko, D. and Jin, S. and others}, title = {{Vitamin E and donepezil for the treatment of mild cognitive impairment}}, journal = {The New England journal of medicine}, year = {2005}, doi = {10.1056/nejmoa050151}, pmid = {15829527}, url = {https://doi.org/10.1056/nejmoa050151} } @article{shao2012-23100399, author = {Shao, H. and Breitner, J. C. and Whitmer, R. A. and Wang, J. and Hayden, K. and Wengreen, H. and Corcoran, C. and Tschanz, J. and others}, title = {{Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e318271f823}, pmid = {23100399}, url = {https://doi.org/10.1212/wnl.0b013e318271f823} } @article{feustel2020-31792092, author = {Feustel, A. C. and MacPherson, A. and Fergusson, D. A. and Kieburtz, K. and Kimmelman, J.}, title = {{Risks and benefits of unapproved disease-modifying treatments for neurodegenerative disease}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000008699}, pmid = {31792092}, url = {https://doi.org/10.1212/wnl.0000000000008699} } @article{dubbelman2025-40440591, author = {Dubbelman, M. A. and Liu, A. and Donohue, M. C. and Langford, O. and Raman, R. and Rentz, D. M. and Amariglio, R. and Sperling, R. A. and others}, title = {{Changes in Daily Functioning in Association With Tau and Amyloid Among Unimpaired Older Adults With and Without Elevated Amyloid}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213775}, pmid = {40440591}, url = {https://doi.org/10.1212/wnl.0000000000213775} } @article{tzeng2018-29488144, author = {Tzeng, N. S. and Chung, C. H. and Lin, F. H. and Chiang, C. P. and Yeh, C. B. and Huang, S. Y. and Lu, R. B. and Chang, H. A. and others}, title = {{Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections-a Nationwide, Population-Based Cohort Study in Taiwan}}, journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics}, year = {2018}, doi = {10.1007/s13311-018-0611-x}, pmid = {29488144}, url = {https://doi.org/10.1007/s13311-018-0611-x} } @article{hansson2023-37202517, author = {Hansson, O. and Blennow, K. and Zetterberg, H. and Dage, J.}, title = {{Blood biomarkers for Alzheimer's disease in clinical practice and trials}}, journal = {Nature aging}, year = {2023}, doi = {10.1038/s43587-023-00403-3}, pmid = {37202517}, url = {https://doi.org/10.1038/s43587-023-00403-3} } @article{husebo2019-32116687, author = {Husebo, B. S. and Heintz, H. L. and Berge, L. I. and Owoyemi, P. and Rahman, A. T. and Vahia, IV.}, title = {{Sensing Technology to Monitor Behavioral and Psychological Symptoms and to Assess Treatment Response in People With Dementia. A Systematic Review}}, journal = {Frontiers in pharmacology}, year = {2019}, doi = {10.3389/fphar.2019.01699}, pmid = {32116687}, url = {https://doi.org/10.3389/fphar.2019.01699} } @article{antolini2021-34531298, author = {Antolini, L. and DiFrancesco, J. C. and Zedde, M. and Basso, G. and Arighi, A. and Shima, A. and Cagnin, A. and Caulo, M. and others}, title = {{Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012778}, pmid = {34531298}, url = {https://doi.org/10.1212/wnl.0000000000012778} } @article{mulnard2000-10697060, author = {Mulnard, R. A. and Cotman, C. W. and Kawas, C. and van Dyck, C. H. and Sano, M. and Doody, R. and Koss, E. and Pfeiffer, E. and others}, title = {{Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study}}, journal = {JAMA}, year = {2000}, doi = {10.1001/jama.283.8.1007}, pmid = {10697060}, url = {https://doi.org/10.1001/jama.283.8.1007} } @article{li2017-28821686, author = {Li, G. and Mayer, C. L. and Morelli, D. and Millard, S. P. and Raskind, W. H. and Petrie, E. C. and Cherrier, M. and Fagan, A. M. and others}, title = {{Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004392}, pmid = {28821686}, url = {https://doi.org/10.1212/wnl.0000000000004392} } @article{berry2023-37040116, author = {Berry, D. A. and Dhadda, S. and Kanekiyo, M. and Li, D. and Swanson, C. J. and Irizarry, M. and Kramer, L. D. and Berry, S. M.}, title = {{Lecanemab for Patients With Early Alzheimer Disease: Bayesian Analysis of a Phase 2b Dose-Finding Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.7230}, pmid = {37040116}, url = {https://doi.org/10.1001/jamanetworkopen.2023.7230} } @article{smith2017-28166234, author = {Smith, D. and Lovell, J. and Weller, C. and Kennedy, B. and Winbolt, M. and Young, C. and Ibrahim, J.}, title = {{A systematic review of medication non-adherence in persons with dementia or cognitive impairment}}, journal = {PloS one}, year = {2017}, doi = {10.1371/journal.pone.0170651}, pmid = {28166234}, url = {https://doi.org/10.1371/journal.pone.0170651} } @article{seppi2019-30653247, author = {Seppi, K. and Ray Chaudhuri, K. and Coelho, M. and Fox, S. H. and Katzenschlager, R. and Perez Lloret, S. and Weintraub, D. and Sampaio, C. and others}, title = {{Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2019}, doi = {10.1002/mds.27602}, pmid = {30653247}, url = {https://doi.org/10.1002/mds.27602} } @article{lu2009-19528519, author = {Lu, P. H. and Edland, S. D. and Teng, E. and Tingus, K. and Petersen, R. C. and Cummings, J. L. and {Alzheimer's Disease Cooperative Study Group}}, title = {{Donepezil delays progression to AD in MCI subjects with depressive symptoms}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181aa52d3}, pmid = {19528519}, url = {https://doi.org/10.1212/wnl.0b013e3181aa52d3} } @article{boon2025-41109234, author = {Boon, B. D. C. and Piura, Y. D. and Moloney, C. M. and Chalk, J. L. and Lincoln, S. J. and Rutledge, M. H. and Rothberg, D. M. and Kouri, N. and others}, title = {{Neuropathological changes and amyloid-related imaging abnormalities in Alzheimer's disease treated with aducanumab versus untreated: a retrospective case-control study}}, journal = {The Lancet. Neurology}, year = {2025}, doi = {10.1016/s1474-4422(25)00313-8}, pmid = {41109234}, url = {https://doi.org/10.1016/s1474-4422(25)00313-8} } @article{aung2023-36930639, author = {Aung, Htein Linn and Alagaratnam, Jasmini and Chan, Phillip and Chow, Felicia C. and Joska, John A. and Falutz, Julian and Letendre, Scott Lee and Lin, Woody and others}, title = {{Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging}}, journal = {The Journal of Infectious Diseases}, year = {2023}, doi = {10.1093/infdis/jiac388}, pmid = {36930639}, url = {https://doi.org/10.1093/infdis/jiac388} } @article{gregson2025-40921943, author = {Gregson, Celia Louise and Armstrong, David and Avgerinou, Christina and Bowden, Jean and Cooper, Cyrus and Douglas, Lucy and Edwards, John and Gittoes, Neil J. L. and others}, title = {{The 2024 UK clinical guideline for the prevention and treatment of osteoporosis}}, journal = {Archives of Osteoporosis}, year = {2025}, doi = {10.1007/s11657-025-01588-3}, pmid = {40921943}, url = {https://doi.org/10.1007/s11657-025-01588-3} } @article{matt2025-40009384, author = {Matt, E. and Mitterwallner, M. and Radjenovic, S. and Grigoryeva, D. and Weber, A. and Stögmann, E. and Domitner, A. and Zettl, A. and others}, title = {{Ultrasound Neuromodulation With Transcranial Pulse Stimulation in Alzheimer Disease: A Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2025}, doi = {10.1001/jamanetworkopen.2024.59170}, pmid = {40009384}, url = {https://doi.org/10.1001/jamanetworkopen.2024.59170} } @article{viswanathan2009-19153374, author = {Viswanathan, A. and Raj, S. and Greenberg, S. M. and Stampfer, M. and Campbell, S. and Hyman, B. T. and Irizarry, M. C.}, title = {{Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial}}, journal = {Neurology}, year = {2009}, doi = {10.1212/01.wnl.0000339486.63862.db}, pmid = {19153374}, url = {https://doi.org/10.1212/01.wnl.0000339486.63862.db} } @article{flo2022-35771851, author = {Flo, B. K. and Matziorinis, A. M. and Skouras, S. and Sudmann, T. T. and Gold, C. and Koelsch, S.}, title = {{Study protocol for the Alzheimer and music therapy study: An RCT to compare the efficacy of music therapy and physical activity on brain plasticity, depressive symptoms, and cognitive decline, in a population with and at risk for Alzheimer's disease}}, journal = {PloS one}, year = {2022}, doi = {10.1371/journal.pone.0270682}, pmid = {35771851}, url = {https://doi.org/10.1371/journal.pone.0270682} } @article{rawal2025-40673737, author = {Rawal, S. and Wildsmith, K. R. and Aluri, J. and Yagi, T. and Chang, M. K. and Niu, H. and Zhou, J. and Horie, K. and others}, title = {{An Anti-tau Therapeutic Antibody Etalanetug (E2814): A Phase 1, First-in-human (FIH) Study of Single and Multiple Ascending Doses in Healthy Subjects}}, journal = {Alzheimer disease and associated disorders}, year = {2025}, doi = {10.1097/wad.0000000000000680}, pmid = {40673737}, url = {https://doi.org/10.1097/wad.0000000000000680} } @article{olazaran2010-20838046, author = {Olazarán, J. and Reisberg, B. and Clare, L. and Cruz, I. and Peña-Casanova, J. and Del Ser, T. and Woods, B. and Beck, C. and others}, title = {{Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy}}, journal = {Dementia and geriatric cognitive disorders}, year = {2010}, doi = {10.1159/000316119}, pmid = {20838046}, url = {https://doi.org/10.1159/000316119} } @article{vanmaanen2016-26606319, author = {van Maanen, A. and Meijer, A. M. and van der Heijden, K. B. and Oort, F. J.}, title = {{The effects of light therapy on sleep problems: A systematic review and meta-analysis}}, journal = {Sleep medicine reviews}, year = {2016}, doi = {10.1016/j.smrv.2015.08.009}, pmid = {26606319}, url = {https://doi.org/10.1016/j.smrv.2015.08.009} } @article{wang2016-27010616, author = {Wang, J. and Logovinsky, V. and Hendrix, S. B. and Stanworth, S. H. and Perdomo, C. and Xu, L. and Dhadda, S. and Do, I. and others}, title = {{ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2016}, doi = {10.1136/jnnp-2015-312383}, pmid = {27010616}, url = {https://doi.org/10.1136/jnnp-2015-312383} } @article{salloway2018-30231896, author = {Salloway, S. and Honigberg, L. A. and Cho, W. and Ward, M. and Friesenhahn, M. and Brunstein, F. and Quartino, A. and Clayton, D. and others}, title = {{Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)}}, journal = {Alzheimer's research \& therapy}, year = {2018}, doi = {10.1186/s13195-018-0424-5}, pmid = {30231896}, url = {https://doi.org/10.1186/s13195-018-0424-5} } @article{dejong2008-18213383, author = {de Jong, D. and Jansen, R. and Hoefnagels, W. and Jellesma-Eggenkamp, M. and Verbeek, M. and Borm, G. and Kremer, B.}, title = {{No effect of one-year treatment with indomethacin on Alzheimer's disease progression: a randomized controlled trial}}, journal = {PloS one}, year = {2008}, doi = {10.1371/journal.pone.0001475}, pmid = {18213383}, url = {https://doi.org/10.1371/journal.pone.0001475} } @article{mo2025-39994788, author = {Mo, Minjia and Abzhandadze, Tamar and Hoang, Minh Tuan and Sacuiu, Simona F. and Jurado, Pol Grau and Pereira, Joana B. and Naia, Luana and Kele, Julianna and others}, title = {{Antidepressant use and cognitive decline in patients with dementia: a national cohort study}}, journal = {BMC Medicine}, year = {2025}, doi = {10.1186/s12916-025-03851-3}, pmid = {39994788}, url = {https://doi.org/10.1186/s12916-025-03851-3} } @article{vanolst2025-40050704, author = {van Olst, L. and Simonton, B. and Edwards, A. J. and Forsyth, A. V. and Boles, J. and Jamshidi, P. and Watson, T. and Shepard, N. and Krainc, T. and Argue, B. M. and Zhang, Z. and Kuruvilla, J. and others}, title = {{Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease}}, journal = {Nature Medicine}, year = {2025}, doi = {10.1038/s41591-025-03574-1}, pmid = {40050704}, url = {https://doi.org/10.1038/s41591-025-03574-1} } @article{pietrzak2015-25629787, author = {Pietrzak, R. H. and Lim, Y. Y. and Neumeister, A. and Ames, D. and Ellis, K. A. and Harrington, K. and Lautenschlager, N. T. and Restrepo, C. and others}, title = {{Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study}}, journal = {JAMA psychiatry}, year = {2015}, doi = {10.1001/jamapsychiatry.2014.2476}, pmid = {25629787}, url = {https://doi.org/10.1001/jamapsychiatry.2014.2476} } @article{lee2023-37930669, author = {Lee, D. and Slomkowski, M. and Hefting, N. and Chen, D. and Larsen, K. G. and Kohegyi, E. and Hobart, M. and Cummings, J. L. and others}, title = {{Brexpiprazole for the Treatment of Agitation in Alzheimer Dementia: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3810}, pmid = {37930669}, url = {https://doi.org/10.1001/jamaneurol.2023.3810} } @article{moraes2008-18198262, author = {Moraes, W. and Poyares, D. and Sukys-Claudino, L. and Guilleminault, C. and Tufik, S.}, title = {{Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebo-controlled study}}, journal = {Chest}, year = {2008}, doi = {10.1378/chest.07-1446}, pmid = {18198262}, url = {https://doi.org/10.1378/chest.07-1446} } @article{ballard2009-19700946, author = {Ballard, C. and Brown, R. and Fossey, J. and Douglas, S. and Bradley, P. and Hancock, J. and James, I. A. and Juszczak, E. and others}, title = {{Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial)}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2009}, doi = {10.1097/jgp.0b013e3181b0f8c0}, pmid = {19700946}, url = {https://doi.org/10.1097/jgp.0b013e3181b0f8c0} } @article{bracco2023-37875856, author = {Bracco, L. and Pinto-Carral, A. and Hillaert, L. and Mourey, F.}, title = {{Tango-therapy vs physical exercise in older people with dementia; a randomized controlled trial}}, journal = {BMC geriatrics}, year = {2023}, doi = {10.1186/s12877-023-04342-x}, pmid = {37875856}, url = {https://doi.org/10.1186/s12877-023-04342-x} } @article{jeste2008-17637610, author = {Jeste, D. V. and Blazer, D. and Casey, D. and Meeks, T. and Salzman, C. and Schneider, L. and Tariot, P. and Yaffe, K.}, title = {{ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia}}, journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology}, year = {2008}, doi = {10.1038/sj.npp.1301492}, pmid = {17637610}, url = {https://doi.org/10.1038/sj.npp.1301492} } @article{thorpe2015-25592195, author = {Thorpe, C. T. and Gellad, W. F. and Good, C. B. and Zhang, S. and Zhao, X. and Mor, M. and Fine, M. J.}, title = {{Tight glycemic control and use of hypoglycemic medications in older veterans with type 2 diabetes and comorbid dementia}}, journal = {Diabetes care}, year = {2015}, doi = {10.2337/dc14-0599}, pmid = {25592195}, url = {https://doi.org/10.2337/dc14-0599} } @article{ide2016-26963387, author = {Ide, M. and Harris, M. and Stevens, A. and Sussams, R. and Hopkins, V. and Culliford, D. and Fuller, J. and Ibbett, P. and others}, title = {{Periodontitis and Cognitive Decline in Alzheimer's Disease}}, journal = {PloS one}, year = {2016}, doi = {10.1371/journal.pone.0151081}, pmid = {26963387}, url = {https://doi.org/10.1371/journal.pone.0151081} } @article{wilcock2002-12409683, author = {Wilcock, G. and Möbius, H. J. and Stöffler, A. and {MMM 500 group}}, title = {{A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500)}}, journal = {International clinical psychopharmacology}, year = {2002}, doi = {10.1097/00004850-200211000-00005}, pmid = {12409683}, url = {https://doi.org/10.1097/00004850-200211000-00005} } @article{xu2021-33741639, author = {Xu, H. and Garcia-Ptacek, S. and Jönsson, L. and Wimo, A. and Nordström, P. and Eriksdotter, M.}, title = {{Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011832}, pmid = {33741639}, url = {https://doi.org/10.1212/wnl.0000000000011832} } @article{bettermann2012-21236699, author = {Bettermann, K. and Arnold, A. M. and Williamson, J. and Rapp, S. and Sink, K. and Toole, J. F. and Carlson, M. C. and Yasar, S. and others}, title = {{Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study}}, journal = {Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association}, year = {2012}, doi = {10.1016/j.jstrokecerebrovasdis.2010.11.002}, pmid = {21236699}, url = {https://doi.org/10.1016/j.jstrokecerebrovasdis.2010.11.002} } @article{xu2024-39177108, author = {Xu, H. and Habich, A. and Ferreira, D. and Elisabet, L. and Westman, E. and Eriksdotter, M.}, title = {{Long-term effects of cholinesterase inhibitors and memantine on cognitive decline, cardiovascular events, and mortality in dementia with Lewy bodies: An up to 10-year follow-up study}}, journal = {Alzheimer's \& Dementia}, year = {2024}, doi = {10.1002/alz.14118}, pmid = {39177108}, url = {https://doi.org/10.1002/alz.14118} } @article{lott2011-21739598, author = {Lott, I. T. and Doran, E. and Nguyen, V. Q. and Tournay, A. and Head, E. and Gillen, D. L.}, title = {{Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation}}, journal = {American journal of medical genetics. Part A}, year = {2011}, doi = {10.1002/ajmg.a.34114}, pmid = {21739598}, url = {https://doi.org/10.1002/ajmg.a.34114} } @article{schneider2016-26771737, author = {Schneider, L. S. and Frangakis, C. and Drye, L. T. and Devanand, D. P. and Marano, C. M. and Mintzer, J. and Mulsant, B. H. and Munro, C. A. and others}, title = {{Heterogeneity of Treatment Response to Citalopram for Patients With Alzheimer's Disease With Aggression or Agitation: The CitAD Randomized Clinical Trial}}, journal = {The American journal of psychiatry}, year = {2016}, doi = {10.1176/appi.ajp.2015.15050648}, pmid = {26771737}, url = {https://doi.org/10.1176/appi.ajp.2015.15050648} } @article{munro2012-23032478, author = {Munro, C. A. and Longmire, C. F. and Drye, L. T. and Martin, B. K. and Frangakis, C. E. and Meinert, C. L. and Mintzer, J. E. and Porsteinsson, A. P. and others}, title = {{Cognitive outcomes after sertaline treatment in patients with depression of Alzheimer disease}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2012}, doi = {10.1097/jgp.0b013e31826ce4c5}, pmid = {23032478}, url = {https://doi.org/10.1097/jgp.0b013e31826ce4c5} } @article{dyer2020-31604674, author = {Dyer, A. H. and Murphy, C. and Lawlor, B. and Kennelly, S. P. and {NILVAD Study Group}}, title = {{Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD}}, journal = {Journal of the American Medical Directors Association}, year = {2020}, doi = {10.1016/j.jamda.2019.08.006}, pmid = {31604674}, url = {https://doi.org/10.1016/j.jamda.2019.08.006} } @article{vanderlip2026-41653883, author = {Vanderlip, C. R. and Gillen, D. L. and Grill, J. D. and Stark, C. E. L.}, title = {{Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer's trials}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100503}, pmid = {41653883}, url = {https://doi.org/10.1016/j.tjpad.2026.100503} } @article{heaton2010-21135382, author = {Heaton, R. K. and Clifford, D. B. and Franklin, D. R. and Woods, S. P. and Ake, C. and Vaida, F. and Ellis, R. J. and Letendre, S. L. and others}, title = {{HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e318200d727}, pmid = {21135382}, url = {https://doi.org/10.1212/wnl.0b013e318200d727} } @article{wilcock2000-11110737, author = {Wilcock, G. K. and Lilienfeld, S. and Gaens, E.}, title = {{Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. Galantamine International-1 Study Group}}, journal = {BMJ (Clinical research ed.)}, year = {2000}, doi = {10.1136/bmj.321.7274.1445}, pmid = {11110737}, url = {https://doi.org/10.1136/bmj.321.7274.1445} } @article{thijssen2020-32123386, author = {Thijssen, E. H. and La Joie, R. and Wolf, A. and Strom, A. and Wang, P. and Iaccarino, L. and Bourakova, V. and Cobigo, Y. and others}, title = {{Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration}}, journal = {Nature medicine}, year = {2020}, doi = {10.1038/s41591-020-0762-2}, pmid = {32123386}, url = {https://doi.org/10.1038/s41591-020-0762-2} } @article{mossello2015-25730775, author = {Mossello, E. and Pieraccioli, M. and Nesti, N. and Bulgaresi, M. and Lorenzi, C. and Caleri, V. and Tonon, E. and Cavallini, M. C. and others}, title = {{Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs}}, journal = {JAMA internal medicine}, year = {2015}, doi = {10.1001/jamainternmed.2014.8164}, pmid = {25730775}, url = {https://doi.org/10.1001/jamainternmed.2014.8164} } @article{rockwood2006-16554498, author = {Rockwood, K. and Fay, S. and Song, X. and MacKnight, C. and Gorman, M.}, title = {{Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: a randomized controlled trial}}, journal = {CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne}, year = {2006}, doi = {10.1503/cmaj.051432}, pmid = {16554498}, url = {https://doi.org/10.1503/cmaj.051432} } @article{cheung2025-40413804, author = {Cheung, Edmund Chi Lok and Adesuyan, Matthew and Szilcz, Máté and Ellett, Lisa M. Kalisch and Shah, Sonia H and Jani, Yogini Hariprasad and Hägg, Sara and Pratt, Nicole L. and others}, title = {{Antihypertensive drug classes and risk of incident dementia: a multinational population-based cohort study}}, journal = {Age and Ageing}, year = {2025}, doi = {10.1093/ageing/afaf121}, pmid = {40413804}, url = {https://doi.org/10.1093/ageing/afaf121} } @article{vassar1999-10531052, author = {Vassar, Robert J. and Bennett, Brian D. and Babu‐Khan, Safura and Kahn, Steve and Mendiaz, Elizabeth A. and Denis, Paul E. and Teplow, David B. and Ross, Sandra L. and others}, title = {{β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE}}, journal = {Science}, year = {1999}, doi = {10.1126/science.286.5440.735}, pmid = {10531052}, url = {https://doi.org/10.1126/science.286.5440.735} } @article{ashton2022-36456833, author = {Ashton, Nicholas James and Janelidze, Shorena and Mattsson, Niklas and Binette, Alexa Pichet and Strandberg, Olof T. and Brum, Wagner Scheeren and Karikari, Thomas K. and González‐Ortiz, Fernando and Di Molfetta, Guglielmo and Meda, Francisco J. and Jonaitis, Erin McMullen and Koscik, Rebecca L. and Cody, Karly Alex and Betthauser, Tobey J. and Li, Yan and Vanmechelen, Eugeen and Palmqvist, Sebastian and Stomrud, Erik and Bateman, Randall John and Zetterberg, Henrik and Johnson, Sterling C. and Blennow, Kaj and Hansson, Oskar}, title = {{Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring}}, journal = {Nature Medicine}, year = {2022}, doi = {10.1038/s41591-022-02074-w}, pmid = {36456833}, url = {https://doi.org/10.1038/s41591-022-02074-w} } @article{vandyck2025-41355080, author = {van Dyck, C. H. and Sperling, R. and Johnson, K. and Dhadda, S. and Kanekiyo, M. and Li, D. and Gee, M. and Hersch, S. and Irizarry, M. and Kramer, L.}, title = {{Long-term safety and efficacy of lecanemab in early Alzheimer's disease: Results from the Clarity AD open-label extension study}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70905}, pmid = {41355080}, url = {https://doi.org/10.1002/alz.70905} } @article{atri2026-42128444, author = {Atri, A. and Apostolova, L. G. and Iwata, A. and Wessels, A. M. and Atkins, A. and Lu, M. and Ye, W. and Ryan, S. and Doty, E. G.}, title = {{Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial}}, journal = {Neurology: Clinical Practice}, year = {2026}, doi = {10.1212/CPJ.0000000000200621}, pmid = {42128444}, url = {https://doi.org/10.1212/CPJ.0000000000200621} } @article{figueiro2019-31855161, author = {Figueiro, M. G. and Plitnick, B. and Roohan, C. and Sahin, L. and Kalsher, M. and Rea, M. S.}, title = {{Effects of a Tailored Lighting Intervention on Sleep Quality, Rest-Activity, Mood, and Behavior in Older Adults With Alzheimer Disease and Related Dementias: A Randomized Clinical Trial}}, journal = {Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine}, year = {2019}, doi = {10.5664/jcsm.8078}, pmid = {31855161}, url = {https://doi.org/10.5664/jcsm.8078} } @article{fields2012-21775876, author = {Fields, C. and Drye, L. and Vaidya, V. and Lyketsos, C. and {ADAPT Research Group}}, title = {{Celecoxib or naproxen treatment does not benefit depressive symptoms in persons age 70 and older: findings from a randomized controlled trial}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2012}, doi = {10.1097/jgp.0b013e318227f4da}, pmid = {21775876}, url = {https://doi.org/10.1097/jgp.0b013e318227f4da} } @article{realdon2016-27887597, author = {Realdon, O. and Rossetto, F. and Nalin, M. and Baroni, I. and Cabinio, M. and Fioravanti, R. and Saibene, F. L. and Alberoni, M. and others}, title = {{Technology-enhanced multi-domain at home continuum of care program with respect to usual care for people with cognitive impairment: the Ability-TelerehABILITation study protocol for a randomized controlled trial}}, journal = {BMC psychiatry}, year = {2016}, doi = {10.1186/s12888-016-1132-y}, pmid = {27887597}, url = {https://doi.org/10.1186/s12888-016-1132-y} } @article{leoutsakos2012-21560159, author = {Leoutsakos, J. M. and Muthen, B. O. and Breitner, J. C. and Lyketsos, C. G. and {ADAPT Research Team}}, title = {{Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial}}, journal = {International journal of geriatric psychiatry}, year = {2012}, doi = {10.1002/gps.2723}, pmid = {21560159}, url = {https://doi.org/10.1002/gps.2723} } @article{study2009-19328435, author = {{ADAPT Research Group} and Meinert, C. L. and McCaffrey, L. D. and Breitner, J. C.}, title = {{Alzheimer's Disease Anti-inflammatory Prevention Trial: design, methods, and baseline results}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2009}, doi = {10.1016/j.jalz.2008.09.004}, pmid = {19328435}, url = {https://doi.org/10.1016/j.jalz.2008.09.004} } @article{grill2024-37830926, author = {Grill, J. D. and Flournoy, C. and Dhadda, S. and Ernstrom, K. and Sperling, R. and Molina-Henry, D. and Tranotti, K. and Harris, R. and others}, title = {{Eligibility Rates among Racially and Ethnically Diverse US Participants in Phase 2 and Phase 3 Placebo-Controlled, Double-Blind, Randomized Trials of Lecanemab and Elenbecestat in Early Alzheimer Disease}}, journal = {Annals of neurology}, year = {2024}, doi = {10.1002/ana.26819}, pmid = {37830926}, url = {https://doi.org/10.1002/ana.26819} } @article{tseng2023-36698219, author = {Tseng, P. T. and Chen, Y. W. and Zeng, B. Y. and Zeng, B. S. and Hung, C. M. and Sun, C. K. and Cheng, Y. S. and Stubbs, B. and others}, title = {{The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials}}, journal = {Alzheimer's research \& therapy}, year = {2023}, doi = {10.1186/s13195-023-01164-2}, pmid = {36698219}, url = {https://doi.org/10.1186/s13195-023-01164-2} } @article{malouf2008-18843658, author = {Malouf, R. and Grimley Evans, J.}, title = {{Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people}}, journal = {The Cochrane database of systematic reviews}, year = {2008}, doi = {10.1002/14651858.cd004514.pub2}, pmid = {18843658}, url = {https://doi.org/10.1002/14651858.cd004514.pub2} } @article{reisberg2003-12672860, author = {Reisberg, B. and Doody, R. and Stöffler, A. and Schmitt, F. and Ferris, S. and Möbius, H. J. and {Memantine Study Group}}, title = {{Memantine in moderate-to-severe Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2003}, doi = {10.1056/nejmoa013128}, pmid = {12672860}, url = {https://doi.org/10.1056/nejmoa013128} } @article{risacher2016-27088965, author = {Risacher, S. L. and McDonald, B. C. and Tallman, E. F. and West, J. D. and Farlow, M. R. and Unverzagt, F. W. and Gao, S. and Boustani, M. and others}, title = {{Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.0580}, pmid = {27088965}, url = {https://doi.org/10.1001/jamaneurol.2016.0580} } @article{jack2008-17452062, author = {Jack, C. R. and Petersen, R. C. and Grundman, M. and Jin, S. and Gamst, A. and Ward, C. P. and Sencakova, D. and Doody, R. S. and others}, title = {{Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI}}, journal = {Neurobiology of aging}, year = {2008}, doi = {10.1016/j.neurobiolaging.2007.03.004}, pmid = {17452062}, url = {https://doi.org/10.1016/j.neurobiolaging.2007.03.004} } @article{rosenberg2022-36130840, author = {Rosenberg, A. and Öhlund-Wistbacka, U. and Hall, A. and Bonnard, A. and Hagman, G. and Rydén, M. and Thunborg, C. and Wiggenraad, F. and others}, title = {{β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201043}, pmid = {36130840}, url = {https://doi.org/10.1212/wnl.0000000000201043} } @article{hanlon2020-32152019, author = {Hanlon, P. and Quinn, T. J. and Gallacher, K. I. and Myint, P. K. and Jani, B. D. and Nicholl, B. I. and Lowrie, R. and Soiza, R. L. and others}, title = {{Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties}}, journal = {Annals of family medicine}, year = {2020}, doi = {10.1370/afm.2501}, pmid = {32152019}, url = {https://doi.org/10.1370/afm.2501} } @article{lin2025-40663350, author = {Lin, Huan-Tang and Tsai, Yung‐Fong and Liao, Pei‐Lun and Wei, James Cheng-Chung}, title = {{Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Patients With Diabetes and Obesity}}, journal = {JAMA Network Open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.21016}, pmid = {40663350}, url = {https://doi.org/10.1001/jamanetworkopen.2025.21016} } @article{bolsewig2025-39881147, author = {Bolsewig, Katharina and Willemse, Eline A.J. and Sánchez‐Juan, Pascual and Rábano, Alberto and Martinez-Castillo, Minerva and Doecke, James D. and Bellomo, Giovanni and Vermunt, Lisa and others}, title = {{Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment}}, journal = {Nature Communications}, year = {2025}, doi = {10.1038/s41467-025-56293-z}, pmid = {39881147}, url = {https://doi.org/10.1038/s41467-025-56293-z} } @article{chiao2019-29777003, author = {Chiao, P. and Bedell, B. J. and Avants, B. and Zijdenbos, A. P. and Grand'Maison, M. and O'Neill, P. and O'Gorman, J. and Chen, T. and others}, title = {{Impact of Reference and Target Region Selection on Amyloid PET SUV Ratios in the Phase 1b PRIME Study of Aducanumab}}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year = {2019}, doi = {10.2967/jnumed.118.209130}, pmid = {29777003}, url = {https://doi.org/10.2967/jnumed.118.209130} } @article{raschetti2007-18044984, author = {Raschetti, R. and Albanese, E. and Vanacore, N. and Maggini, M.}, title = {{Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials}}, journal = {PLoS medicine}, year = {2007}, doi = {10.1371/journal.pmed.0040338}, pmid = {18044984}, url = {https://doi.org/10.1371/journal.pmed.0040338} } @article{reuben2024-38436963, author = {Reuben, D. B. and Kremen, S. and Maust, D. T.}, title = {{Dementia Prevention and Treatment: A Narrative Review}}, journal = {JAMA internal medicine}, year = {2024}, doi = {10.1001/jamainternmed.2023.8522}, pmid = {38436963}, url = {https://doi.org/10.1001/jamainternmed.2023.8522} } @article{mittelman2008-18978250, author = {Mittelman, M. S. and Brodaty, H. and Wallen, A. S. and Burns, A.}, title = {{A three-country randomized controlled trial of a psychosocial intervention for caregivers combined with pharmacological treatment for patients with Alzheimer disease: effects on caregiver depression}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2008}, doi = {10.1097/jgp.0b013e3181898095}, pmid = {18978250}, url = {https://doi.org/10.1097/jgp.0b013e3181898095} } @article{stanley2013-23567399, author = {Stanley, M. A. and Calleo, J. and Bush, A. L. and Wilson, N. and Snow, A. L. and Kraus-Schuman, C. and Paukert, A. L. and Petersen, N. J. and others}, title = {{The peaceful mind program: a pilot test of a cognitive-behavioral therapy-based intervention for anxious patients with dementia}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2013}, doi = {10.1016/j.jagp.2013.01.007}, pmid = {23567399}, url = {https://doi.org/10.1016/j.jagp.2013.01.007} } @article{jung2025-40908201, author = {Jung, J. H. and Kong, N. and Lee, S. and {A4 and LEARN Study Teams}}, title = {{Pulse pressure as a predictor of Alzheimer's disease biomarkers and cognitive decline: The moderating role of APOE ε4}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100363}, pmid = {40908201}, url = {https://doi.org/10.1016/j.tjpad.2025.100363} } @article{marinus2018-29699914, author = {Marinus, J. and Zhu, K. and Marras, C. and Aarsland, D. and van Hilten, J. J.}, title = {{Risk factors for non-motor symptoms in Parkinson's disease}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(18)30127-3}, pmid = {29699914}, url = {https://doi.org/10.1016/s1474-4422(18)30127-3} } @article{burns1999-10325453, author = {Burns, A. and Rossor, M. and Hecker, J. and Gauthier, S. and Petit, H. and Möller, H. J. and Rogers, S. L. and Friedhoff, L. T.}, title = {{The effects of donepezil in Alzheimer's disease - results from a multinational trial}}, journal = {Dementia and geriatric cognitive disorders}, year = {1999}, doi = {10.1159/000017126}, pmid = {10325453}, url = {https://doi.org/10.1159/000017126} } @article{auger2015-26414986, author = {Auger, R. R. and Burgess, H. J. and Emens, J. S. and Deriy, L. V. and Thomas, S. M. and Sharkey, K. M.}, title = {{Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015: An American Academy of Sleep Medicine Clinical Practice Guideline}}, journal = {Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine}, year = {2015}, doi = {10.5664/jcsm.5100}, pmid = {26414986}, url = {https://doi.org/10.5664/jcsm.5100} } @article{molinuevo2018-30488277, author = {Molinuevo, J. L. and Ayton, S. and Batrla, R. and Bednar, M. M. and Bittner, T. and Cummings, J. and Fagan, A. M. and Hampel, H. and others}, title = {{Current state of Alzheimer's fluid biomarkers}}, journal = {Acta neuropathologica}, year = {2018}, doi = {10.1007/s00401-018-1932-x}, pmid = {30488277}, url = {https://doi.org/10.1007/s00401-018-1932-x} } @article{jeremic2025-40194268, author = {Jeremic, D. and Navarro-Lopez, J. D. and Jimenez-Diaz, L.}, title = {{Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application}}, journal = {Journal of medical Internet research}, year = {2025}, doi = {10.2196/68454}, pmid = {40194268}, url = {https://doi.org/10.2196/68454} } @article{tseng2025-41359407, author = {Tseng, Ping‐Tao and Zeng, Bing‐Yan and Hsu, Chih‐Wei and Suen, Mein‐Woei and Hung, Chao‐Ming and Carvalho, Andre Ferrer and Stubbs, Brendon and Chen, Yen‐Wen and others}, title = {{The concentration-dependent protective effects by new generation hypoglycemic agents on delirium, depression, dementia and coma: evidence from a network meta-analysis}}, journal = {Journal of the Royal Society of Medicine}, year = {2025}, doi = {10.1177/01410768251395877}, pmid = {41359407}, url = {https://doi.org/10.1177/01410768251395877} } @article{nakamura2024-39369280, author = {Nakamura, Y. and Adachi, J. and Hirota, N. and Iba, K. and Shimizu, K. and Nakai, M. and Takahashi, K. and Mori, N.}, title = {{Brexpiprazole treatment for agitation in Alzheimer's dementia: A randomized study}}, journal = {Alzheimer's \& Dementia}, year = {2024}, doi = {10.1002/alz.14282}, pmid = {39369280}, url = {https://doi.org/10.1002/alz.14282} } @article{havrengthery2024-38812028, author = {Havreng-Théry, C. and Oquendo, B. and Zolnowski-Kolp, V. and Krolak-Salmon, P. and Bertin-Hugault, F. and Lafuente-Lafuente, C. and Belmin, J.}, title = {{Cholinesterase inhibitors and memantine are associated with a reduced mortality in nursing home residents with dementia: a longitudinal observational study}}, journal = {Alzheimer's Research \& Therapy}, year = {2024}, doi = {10.1186/s13195-024-01481-0}, pmid = {38812028}, url = {https://doi.org/10.1186/s13195-024-01481-0} } @article{pilotto2009-19738170, author = {Pilotto, A. and Franceschi, M. and D'Onofrio, G. and Bizzarro, A. and Mangialasche, F. and Cascavilla, L. and Paris, F. and Matera, M. G. and others}, title = {{Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181b6bbe3}, pmid = {19738170}, url = {https://doi.org/10.1212/wnl.0b013e3181b6bbe3} } @article{kieburtz2010-20142523, author = {Kieburtz, K. and McDermott, M. P. and Voss, T. S. and Corey-Bloom, J. and Deuel, L. M. and Dorsey, E. R. and Factor, S. and Geschwind, M. D. and others}, title = {{A randomized, placebo-controlled trial of latrepirdine in Huntington disease}}, journal = {Archives of neurology}, year = {2010}, doi = {10.1001/archneurol.2009.334}, pmid = {20142523}, url = {https://doi.org/10.1001/archneurol.2009.334} } @article{lee2024-38875437, author = {Lee, W. and Kim, M.}, title = {{Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial}}, journal = {Medicine}, year = {2024}, doi = {10.1097/md.0000000000038067}, pmid = {38875437}, url = {https://doi.org/10.1097/md.0000000000038067} } @article{coughlan2023-37010830, author = {Coughlan, G. T. and Betthauser, T. J. and Boyle, R. and Koscik, R. L. and Klinger, H. M. and Chibnik, L. B. and Jonaitis, E. M. and Yau, W. W. and others}, title = {{Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.0455}, pmid = {37010830}, url = {https://doi.org/10.1001/jamaneurol.2023.0455} } @article{foltynie2024-38245250, author = {Foltynie, T. and Bruno, V. and Fox, S. and Kühn, A. A. and Lindop, F. and Lees, A. J.}, title = {{Medical, surgical, and physical treatments for Parkinson's disease}}, journal = {Lancet (London, England)}, year = {2024}, doi = {10.1016/s0140-6736(23)01429-0}, pmid = {38245250}, url = {https://doi.org/10.1016/s0140-6736(23)01429-0} } @article{kales2015-25731881, author = {Kales, H. C. and Gitlin, L. N. and Lyketsos, C. G.}, title = {{Assessment and management of behavioral and psychological symptoms of dementia}}, journal = {BMJ (Clinical research ed.)}, year = {2015}, doi = {10.1136/bmj.h369}, pmid = {25731881}, url = {https://doi.org/10.1136/bmj.h369} } @article{becker2017-28405022, author = {Becker, L. A. and Huang, B. and Bieri, G. and Ma, R. and Knowles, D. A. and Jafar-Nejad, P. and Messing, J. and Kim, H. J. and others}, title = {{Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice}}, journal = {Nature}, year = {2017}, doi = {10.1038/nature22038}, pmid = {28405022}, url = {https://doi.org/10.1038/nature22038} } @article{schneider2011-21220675, author = {Schneider, L. S. and Insel, P. S. and Weiner, M. W. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2010.343}, pmid = {21220675}, url = {https://doi.org/10.1001/archneurol.2010.343} } @article{damesquita2021-33911285, author = {Da Mesquita, S. and Papadopoulos, Z. and Dykstra, T. and Brase, L. and Farias, F. G. and Wall, M. and Jiang, H. and Kodira, C. D. and others}, title = {{Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy}}, journal = {Nature}, year = {2021}, doi = {10.1038/s41586-021-03489-0}, pmid = {33911285}, url = {https://doi.org/10.1038/s41586-021-03489-0} } @article{brown2025-41396614, author = {Brown, Christopher Andrew and Mundada, Nidhi S. and Cousins, Katheryn A Q and Sadeghpour, Niyousha and Lyu, Xueying and McGrew, Emily and Korecka, Magdalena and Chen‐Plotkin, Alice S. and others}, title = {{Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clinical Mismatch}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.4974}, pmid = {41396614}, url = {https://doi.org/10.1001/jamaneurol.2025.4974} } @article{tang2025-40193118, author = {Tang, Huilin and Donahoo, William Troy and DeKosky, Steven T. and Lee, Yao An and Kotecha, Pareeta and Svensson, Mikael A. and Bian, Jiang and Guo, Jingchuan Serena}, title = {{GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related Dementias}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.0353}, pmid = {40193118}, url = {https://doi.org/10.1001/jamaneurol.2025.0353} } @article{cribb2025-39894022, author = {Cribb, Lachlan and Moreno‐Betancur, Margarita and Wu, Zimu and Wolfe, Rory and Pase, Matthew Paul and Ryan, Joanne L.}, title = {{Moving beyond the prevalent exposure design for causal inference in dementia research}}, journal = {The Lancet Healthy Longevity}, year = {2025}, doi = {10.1016/j.lanhl.2024.100675}, pmid = {39894022}, url = {https://doi.org/10.1016/j.lanhl.2024.100675} } @article{worrall2026-1bda82c8, author = {Worrall, Bradford B. and Ratan, Rajiv R.}, title = {{What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia?}}, journal = {Neurology Genetics}, year = {2026}, doi = {10.1212/nxg.0000000000200450}, url = {https://doi.org/10.1212/nxg.0000000000200450} } @article{sano1997-9110909, author = {Sano, Mary and Ernesto, Christopher and Thomas, Ronald G. and Klauber, Melville R. and Schafer, Kimberly A and Grundman, Michael and Woodbury, Peter and Growdon, John H. and Cotman, Carl W. and Pfeiffer, Eric A. and Schneider, Lon S. and Thal, Leon J.}, title = {{A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study}}, journal = {New England Journal of Medicine}, year = {1997}, doi = {10.1056/nejm199704243361704}, pmid = {9110909}, url = {https://doi.org/10.1056/nejm199704243361704} } @article{lista2024-39080712, author = {Lista, S. and Imbimbo, B. P. and Grasso, M. and Fidilio, A. and Emanuele, E. and Minoretti, P. and López-Ortiz, S. and Martín-Hernández, J. and others}, title = {{Tracking neuroinflammatory biomarkers in Alzheimer's disease: a strategy for individualized therapeutic approaches?}}, journal = {Journal of neuroinflammation}, year = {2024}, doi = {10.1186/s12974-024-03163-y}, pmid = {39080712}, url = {https://doi.org/10.1186/s12974-024-03163-y} } @article{kim2020-31977846, author = {Kim, Y. and Cho, S. H.}, title = {{Danggui-Shaoyao-San for dementia: A PRISMA-compliant systematic review and meta-analysis}}, journal = {Medicine}, year = {2020}, doi = {10.1097/md.0000000000018507}, pmid = {31977846}, url = {https://doi.org/10.1097/md.0000000000018507} } @article{ballard2015-25523285, author = {Ballard, C. and Thomas, A. and Gerry, S. and Yu, L. M. and Aarsland, D. and Merritt, C. and Corbett, A. and Davison, C. and others}, title = {{A double-blind randomized placebo-controlled withdrawal trial comparing memantine and antipsychotics for the long-term treatment of function and neuropsychiatric symptoms in people with Alzheimer's disease (MAIN-AD)}}, journal = {Journal of the American Medical Directors Association}, year = {2015}, doi = {10.1016/j.jamda.2014.11.002}, pmid = {25523285}, url = {https://doi.org/10.1016/j.jamda.2014.11.002} } @article{cations2018-29672559, author = {Cations, M. and Radisic, G. and Crotty, M. and Laver, K. E.}, title = {{What does the general public understand about prevention and treatment of dementia? A systematic review of population-based surveys}}, journal = {PloS one}, year = {2018}, doi = {10.1371/journal.pone.0196085}, pmid = {29672559}, url = {https://doi.org/10.1371/journal.pone.0196085} } @article{saleh2023-36624497, author = {Saleh, R. N. M. and Hornberger, M. and Ritchie, C. W. and Minihane, A. M.}, title = {{Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer's Disease (EPAD) cohort}}, journal = {Alzheimer's research \& therapy}, year = {2023}, doi = {10.1186/s13195-022-01121-5}, pmid = {36624497}, url = {https://doi.org/10.1186/s13195-022-01121-5} } @article{gascasalas2021-33536430, author = {Gasca-Salas, C. and Fernández-Rodríguez, B. and Pineda-Pardo, J. A. and Rodríguez-Rojas, R. and Obeso, I. and Hernández-Fernández, F. and Del Álamo, M. and Mata, D. and others}, title = {{Blood-brain barrier opening with focused ultrasound in Parkinson's disease dementia}}, journal = {Nature communications}, year = {2021}, doi = {10.1038/s41467-021-21022-9}, pmid = {33536430}, url = {https://doi.org/10.1038/s41467-021-21022-9} } @article{joshi2021-33985348, author = {Joshi, Y. B. and Thomas, M. L. and Braff, D. L. and Green, M. F. and Gur, R. C. and Gur, R. E. and Nuechterlein, K. H. and Stone, W. S. and others}, title = {{Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia}}, journal = {The American journal of psychiatry}, year = {2021}, doi = {10.1176/appi.ajp.2020.20081212}, pmid = {33985348}, url = {https://doi.org/10.1176/appi.ajp.2020.20081212} } @article{moon2020-32375661, author = {Moon, S. and Park, K.}, title = {{The effect of digital reminiscence therapy on people with dementia: a pilot randomized controlled trial}}, journal = {BMC geriatrics}, year = {2020}, doi = {10.1186/s12877-020-01563-2}, pmid = {32375661}, url = {https://doi.org/10.1186/s12877-020-01563-2} } @article{parnetti2019-30646955, author = {Parnetti, L. and Chipi, E. and Salvadori, N. and D'Andrea, K. and Eusebi, P.}, title = {{Prevalence and risk of progression of preclinical Alzheimer's disease stages: a systematic review and meta-analysis}}, journal = {Alzheimer's research \& therapy}, year = {2019}, doi = {10.1186/s13195-018-0459-7}, pmid = {30646955}, url = {https://doi.org/10.1186/s13195-018-0459-7} } @article{pittock2023-37586881, author = {Pittock, R. R. and Aakre, J. A. and Castillo, A. M. and Ramanan, V. K. and Kremers, W. K. and Jack, C. R. and Vemuri, P. and Lowe, V. J. and others}, title = {{Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207770}, pmid = {37586881}, url = {https://doi.org/10.1212/wnl.0000000000207770} } @article{akhondzadeh2010-20831681, author = {Akhondzadeh, S. and Sabet, M. S. and Harirchian, M. H. and Togha, M. and Cheraghmakani, H. and Razeghi, S. and SSh, Hejazi and Yousefi, M. H. and others}, title = {{Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial}}, journal = {Journal of clinical pharmacy and therapeutics}, year = {2010}, doi = {10.1111/j.1365-2710.2009.01133.x}, pmid = {20831681}, url = {https://doi.org/10.1111/j.1365-2710.2009.01133.x} } @article{onder2005-16260821, author = {Onder, G. and Zanetti, O. and Giacobini, E. and Frisoni, G. B. and Bartorelli, L. and Carbone, G. and Lambertucci, P. and others}, title = {{Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: randomised controlled trial}}, journal = {The British journal of psychiatry : the journal of mental science}, year = {2005}, doi = {10.1192/bjp.187.5.450}, pmid = {16260821}, url = {https://doi.org/10.1192/bjp.187.5.450} } @article{albertyn2025-40479610, author = {Albertyn, C. P. and Guu, T. W. and Chu, P. and Creese, B. and Young, A. and Velayudhan, L. and Bhattacharyya, S. and Jafari, H. and Kaur, S. and Kandangwa, P. and others}, title = {{Sativex (nabiximols) for the treatment of Agitation \& Aggression in Alzheimer's dementia in UK nursing homes: a randomised, double-blind, placebo-controlled feasibility trial}}, journal = {Age and Ageing}, year = {2025}, doi = {10.1093/ageing/afaf149}, pmid = {40479610}, url = {https://doi.org/10.1093/ageing/afaf149} } @article{koch2018-29277405, author = {Koch, G. and Bonnì, S. and Pellicciari, M. C. and Casula, E. P. and Mancini, M. and Esposito, R. and Ponzo, V. and Picazio, S. and others}, title = {{Transcranial magnetic stimulation of the precuneus enhances memory and neural activity in prodromal Alzheimer's disease}}, journal = {NeuroImage}, year = {2018}, doi = {10.1016/j.neuroimage.2017.12.048}, pmid = {29277405}, url = {https://doi.org/10.1016/j.neuroimage.2017.12.048} } @article{brodaty2009-19705519, author = {Brodaty, H. and Mittelman, M. and Gibson, L. and Seeher, K. and Burns, A.}, title = {{The effects of counseling spouse caregivers of people with Alzheimer disease taking donepezil and of country of residence on rates of admission to nursing homes and mortality}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2009}, doi = {10.1097/jgp.0b013e3181a65187}, pmid = {19705519}, url = {https://doi.org/10.1097/jgp.0b013e3181a65187} } @article{drye2013-23567407, author = {Drye, L. T. and Scherer, R. W. and Lanctôt, K. L. and Rosenberg, P. B. and Herrmann, N. and Bachman, D. and Mintzer, J. E. and {ADMET Research Group}}, title = {{Designing a trial to evaluate potential treatments for apathy in dementia: the apathy in dementia methylphenidate trial (ADMET)}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2013}, doi = {10.1016/j.jagp.2012.12.018}, pmid = {23567407}, url = {https://doi.org/10.1016/j.jagp.2012.12.018} } @article{mohamed2012-21939611, author = {Mohamed, S. and Rosenheck, R. and Lyketsos, C. G. and Kaczynski, R. and Sultzer, D. L. and Schneider, L. S.}, title = {{Effect of second-generation antipsychotics on caregiver burden in Alzheimer's disease}}, journal = {The Journal of clinical psychiatry}, year = {2012}, doi = {10.4088/jcp.10m06574}, pmid = {21939611}, url = {https://doi.org/10.4088/jcp.10m06574} } @article{fortea2021-34687637, author = {Fortea, J. and Zaman, S. H. and Hartley, S. and Rafii, M. S. and Head, E. and Carmona-Iragui, M.}, title = {{Alzheimer's disease associated with Down syndrome: a genetic form of dementia}}, journal = {The Lancet. Neurology}, year = {2021}, doi = {10.1016/s1474-4422(21)00245-3}, pmid = {34687637}, url = {https://doi.org/10.1016/s1474-4422(21)00245-3} } @article{doody2001-11342679, author = {Doody, R. S. and Stevens, J. C. and Beck, C. and Dubinsky, R. M. and Kaye, J. A. and Gwyther, L. and Mohs, R. C. and Thal, L. J. and others}, title = {{Practice parameter: management of dementia (an evidence-based review) [RETIRED]. Report of the Quality Standards Subcommittee of the American Academy of Neurology}}, journal = {Neurology}, year = {2001}, doi = {10.1212/wnl.56.9.1154}, pmid = {11342679}, url = {https://doi.org/10.1212/wnl.56.9.1154} } @article{aarsland2021-34210995, author = {Aarsland, D. and Batzu, L. and Halliday, G. M. and Geurtsen, G. J. and Ballard, C. and Ray Chaudhuri, K. and Weintraub, D.}, title = {{Parkinson disease-associated cognitive impairment}}, journal = {Nature reviews. Disease primers}, year = {2021}, doi = {10.1038/s41572-021-00280-3}, pmid = {34210995}, url = {https://doi.org/10.1038/s41572-021-00280-3} } @article{kim2019-30621676, author = {Kim, H. and Kim, H. K. and Kim, S. Y. and Kim, Y. I. and Yoo, H. R. and Jung, I. C.}, title = {{Cognitive improvement effects of electro-acupuncture for the treatment of MCI compared with Western medications: a systematic review and Meta-analysis}}, journal = {BMC complementary and alternative medicine}, year = {2019}, doi = {10.1186/s12906-018-2407-2}, pmid = {30621676}, url = {https://doi.org/10.1186/s12906-018-2407-2} } @article{loomis2024-38165296, author = {Loomis, S. J. and Miller, R. and Castrillo-Viguera, C. and Umans, K. and Cheng, W. and O'Gorman, J. and Hughes, R. and Budd Haeberlein, S. and others}, title = {{Genome-Wide Association Studies of ARIA From the Aducanumab Phase 3 ENGAGE and EMERGE Studies}}, journal = {Neurology}, year = {2024}, doi = {10.1212/wnl.0000000000207919}, pmid = {38165296}, url = {https://doi.org/10.1212/wnl.0000000000207919} } @article{knight2018-29734182, author = {Knight, R. and Khondoker, M. and Magill, N. and Stewart, R. and Landau, S.}, title = {{A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia}}, journal = {Dementia and geriatric cognitive disorders}, year = {2018}, doi = {10.1159/000486546}, pmid = {29734182}, url = {https://doi.org/10.1159/000486546} } @article{suswidiantoro2026-41808871, author = {Suswidiantoro, V. and Tang, K. S. and Rahman, K. and Ariestanti, D. M. and James, R. J. and Yan, C. C. and Kato, M. and Saputri, F. C.}, title = {{Natural compounds as multitarget agents in Alzheimer's diseases: evidence from in vivo and in vitro models}}, journal = {Frontiers in pharmacology}, year = {2026}, doi = {10.3389/fphar.2026.1766470}, pmid = {41808871}, url = {https://doi.org/10.3389/fphar.2026.1766470} } @article{long2019-31564456, author = {Long, Justin M. and Holtzman, David M.}, title = {{Alzheimer Disease: An Update on Pathobiology and Treatment Strategies}}, journal = {Cell}, year = {2019}, doi = {10.1016/j.cell.2019.09.001}, pmid = {31564456}, url = {https://doi.org/10.1016/j.cell.2019.09.001} } @article{dewilde2018-29889941, author = {de Wilde, A. and van der Flier, W. M. and Pelkmans, W. and Bouwman, F. and Verwer, J. and Groot, C. and van Buchem, M. M. and Zwan, M. and others}, title = {{Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort: The ABIDE Project}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2018.1346}, pmid = {29889941}, url = {https://doi.org/10.1001/jamaneurol.2018.1346} } @article{lim2022-35099506, author = {Lim, Y. Y. and Maruff, P. and Barthélemy, N. R. and Goate, A. and Hassenstab, J. and Sato, C. and Fagan, A. M. and Benzinger, T. L. S. and others}, title = {{Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2021.5181}, pmid = {35099506}, url = {https://doi.org/10.1001/jamaneurol.2021.5181} } @article{papatsimpas2023-37509042, author = {Papatsimpas, V. and Vrouva, S. and Papathanasiou, G. and Papadopoulou, M. and Bouzineki, C. and Kanellopoulou, S. and Moutafi, D. and Bakalidou, D.}, title = {{Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer's Disease? A Randomized Controlled Trial}}, journal = {Brain sciences}, year = {2023}, doi = {10.3390/brainsci13071112}, pmid = {37509042}, url = {https://doi.org/10.3390/brainsci13071112} } @article{silveira2025-40587145, author = {Silveira, C. R. A. and Coleman, K. K. L. and Borron, K. and Tirona, R. G. and Rupar, C. A. and Zou, G. and Hegele, R. A. and Wellington, C. and others}, title = {{Ambroxol as a Treatment for Parkinson Disease Dementia: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.1687}, pmid = {40587145}, url = {https://doi.org/10.1001/jamaneurol.2025.1687} } @article{sabbagh2023-37695107, author = {Sabbagh, M. N. and Mathew, P. and Blau, A.}, title = {{A Randomized Double-blind Study to Assess the Skin Irritation and Sensitization Potential of a Once-weekly Donepezil Transdermal Delivery System in Healthy Volunteers}}, journal = {Alzheimer disease and associated disorders}, year = {2023}, doi = {10.1097/wad.0000000000000578}, pmid = {37695107}, url = {https://doi.org/10.1097/wad.0000000000000578} } @article{flynnlongmire2014-24314887, author = {Flynn Longmire, C. V. and Drye, L. T. and Frangakis, C. E. and Martin, B. K. and Meinert, C. L. and Mintzer, J. E. and Munro, C. A. and Porsteinsson, A. P. and others}, title = {{Is sertraline treatment or depression remission in depressed Alzheimer patients associated with improved caregiver well being? Depression in Alzheimer's Disease Study 2}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2014}, doi = {10.1016/j.jagp.2013.02.014}, pmid = {24314887}, url = {https://doi.org/10.1016/j.jagp.2013.02.014} } @article{moletbenhamou2022-36097005, author = {Molet-Benhamou, L. and Giudici, K. V. and de Souto Barreto, P. and Cantet, C. and Rolland, Y. and {MAPT/DSA group}}, title = {{Association between urate-lowering therapies and cognitive decline in community-dwelling older adults}}, journal = {Scientific reports}, year = {2022}, doi = {10.1038/s41598-022-17808-6}, pmid = {36097005}, url = {https://doi.org/10.1038/s41598-022-17808-6} } @article{akner2001-11451713, author = {Akner, G. and Cederholm, T.}, title = {{Treatment of protein-energy malnutrition in chronic nonmalignant disorders}}, journal = {The American journal of clinical nutrition}, year = {2001}, doi = {10.1093/ajcn/74.1.6}, pmid = {11451713}, url = {https://doi.org/10.1093/ajcn/74.1.6} } @article{panza2015-25732217, author = {Panza, F. and Solfrizzi, V. and Barulli, M. R. and Bonfiglio, C. and Guerra, V. and Osella, A. and Seripa, D. and Sabbà, C. and others}, title = {{Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review}}, journal = {The journal of nutrition, health \& aging}, year = {2015}, doi = {10.1007/s12603-014-0563-8}, pmid = {25732217}, url = {https://doi.org/10.1007/s12603-014-0563-8} } @article{xu2020-33083543, author = {Xu, J. and Wang, F. and Xu, Z. and Adekkanattu, P. and Brandt, P. and Jiang, G. and Kiefer, R. C. and Luo, Y. and others}, title = {{Data-driven discovery of probable Alzheimer's disease and related dementia subphenotypes using electronic health records}}, journal = {Learning health systems}, year = {2020}, doi = {10.1002/lrh2.10246}, pmid = {33083543}, url = {https://doi.org/10.1002/lrh2.10246} } @article{ott1996-8933010, author = {Ott, A. and Stolk, R. P. and Hofman, A. and van Harskamp, F. and Grobbee, D. E. and Breteler, M. M.}, title = {{Association of diabetes mellitus and dementia: the Rotterdam Study}}, journal = {Diabetologia}, year = {1996}, doi = {10.1007/s001250050588}, pmid = {8933010}, url = {https://doi.org/10.1007/s001250050588} } @article{gao2023-37735487, author = {Gao, C. and Jiang, J. and Tan, Y. and Chen, S.}, title = {{Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets}}, journal = {Signal transduction and targeted therapy}, year = {2023}, doi = {10.1038/s41392-023-01588-0}, pmid = {37735487}, url = {https://doi.org/10.1038/s41392-023-01588-0} } @article{rabinovici2025-40155270, author = {Rabinovici, G. D. and Selkoe, D. J. and Schindler, S. E. and Aisen, P. and Apostolova, L. G. and Atri, A. and Greenberg, S. M. and Hendrix, S. B. and others}, title = {{Donanemab: Appropriate use recommendations}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100150}, pmid = {40155270}, url = {https://doi.org/10.1016/j.tjpad.2025.100150} } @article{liss2021-33458891, author = {Liss, J. L. and Seleri Assunção, S. and Cummings, J. and Atri, A. and Geldmacher, D. S. and Candela, S. F. and Devanand, D. P. and Fillit, H. M. and others}, title = {{Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis}}, journal = {Journal of internal medicine}, year = {2021}, doi = {10.1111/joim.13244}, pmid = {33458891}, url = {https://doi.org/10.1111/joim.13244} } @article{cations2021-34021203, author = {Cations, Monica and Lang, Catherine E. and Ward, Stephanie Alison and Caughey, Gillian Elizabeth and Crotty, Maria and Whitehead, Craig and Ahern, Susannah and Maddison, John and others}, title = {{Using data linkage for national surveillance of clinical quality indicators for dementia care among Australian aged care users}}, journal = {Scientific Reports}, year = {2021}, doi = {10.1038/s41598-021-89646-x}, pmid = {34021203}, url = {https://doi.org/10.1038/s41598-021-89646-x} } @article{gibbons2024-39046728, author = {Gibbons, Robert David and Olfson, Mark and Saulsberry, Loren and Edlund, Mark J. and Zangeneh, Sahar Z. and Bareis, Natalie and Chwastiak, Lydia and Gibbons, Jason Brian and others}, title = {{Social Vulnerability and Prevalence and Treatment for Mental Health and Substance Use Disorders}}, journal = {JAMA Psychiatry}, year = {2024}, doi = {10.1001/jamapsychiatry.2024.1870}, pmid = {39046728}, url = {https://doi.org/10.1001/jamapsychiatry.2024.1870} } @article{clocchiattituozzo2025-40549373, author = {Clocchiatti‐Tuozzo, Santiago and Rivier, Cyprien A. and Renedo, Daniela B. and Huo, Shufan and de Havenon, Adam and Hawkes, Maximiliano A. and Gilmore, Emily J. and Schwamm, Lee H. and others}, title = {{APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.0182}, pmid = {40549373}, url = {https://doi.org/10.1001/jamaneurol.2025.0182} } @article{chen2025-40189473, author = {Chen, Christopher and Katayama, Sadao and Lee, Jae Hong and Lee, Jun-Young and Nakagawa, Masaki and Torii, Kentaro and Ogawa, Tomoo and Dash, Amitabh and others}, title = {{Clarity AD: Asian regional analysis of a phase III trial of lecanemab in early Alzheimer's disease}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100160}, pmid = {40189473}, url = {https://doi.org/10.1016/j.tjpad.2025.100160} } @article{garegnani2025-40792601, author = {Garegnani, Luis and Ivaldi, Diego and Burgos, Mariana Andrea and Varela, Lucia B and Menai, Samanta Díaz and Rico, Sabrina and Giménez, María Lucía and Liquitay, Camila Micaela Escobar and others}, title = {{Exercise therapy for the treatment of delirium in the intensive care unit}}, journal = {Cochrane Database of Systematic Reviews}, year = {2025}, doi = {10.1002/14651858.cd015830.pub2}, pmid = {40792601}, url = {https://doi.org/10.1002/14651858.cd015830.pub2} } @article{bianchi2026-42613673, author = {Bianchi, Federica and Broers, Barbara and Desmeules, Jules Alexandre and Langlois, Angeline and Wampfler, James and Curtin, François and Pautex, Sophie}, title = {{A randomised, double-blind, placebo-controlled crossover trial on cannabinoid-based medication for behavioural disorders in old patients with severe dementia: the study results}}, journal = {Age and ageing}, year = {2026}, doi = {10.1093/ageing/afag239}, pmid = {42613673}, url = {https://doi.org/10.1093/ageing/afag239} } @article{plowey2022-35581440, author = {Plowey, E. D. and Bussiere, T. and Rajagovindan, R. and Sebalusky, J. and Hamann, S. and von Hehn, C. and Castrillo-Viguera, C. and Sandrock, A. and others}, title = {{Alzheimer disease neuropathology in a patient previously treated with aducanumab}}, journal = {Acta neuropathologica}, year = {2022}, doi = {10.1007/s00401-022-02433-4}, pmid = {35581440}, url = {https://doi.org/10.1007/s00401-022-02433-4} } @article{ligthart2010-20859546, author = {Ligthart, S. A. and Moll van Charante, E. P. and Van Gool, W. A. and Richard, E.}, title = {{Treatment of cardiovascular risk factors to prevent cognitive decline and dementia: a systematic review}}, journal = {Vascular health and risk management}, year = {2010}, doi = {10.2147/vhrm.s7343}, pmid = {20859546}, url = {https://doi.org/10.2147/vhrm.s7343} } @article{jiang2025-40059211, author = {Jiang, Q. and Liu, J. and Huang, S. and Wang, X. Y. and Chen, X. and Liu, G. H. and Ye, K. and Song, W. and others}, title = {{Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances}}, journal = {Signal transduction and targeted therapy}, year = {2025}, doi = {10.1038/s41392-025-02145-7}, pmid = {40059211}, url = {https://doi.org/10.1038/s41392-025-02145-7} } @article{korben2022-35075293, author = {Korben, V. A. and Lyashchenko, A. K. and Blanco-Redondo, B. and Jafar-Nejad, P. and Shneider, N. A.}, title = {{Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis}}, journal = {Nature medicine}, year = {2022}, doi = {10.1038/s41591-021-01615-z}, pmid = {35075293}, url = {https://doi.org/10.1038/s41591-021-01615-z} } @article{dunietz2021-33769542, author = {Dunietz, G. L. and Chervin, R. D. and Burke, J. F. and Conceicao, A. S. and Braley, T. J.}, title = {{Obstructive sleep apnea treatment and dementia risk in older adults}}, journal = {Sleep}, year = {2021}, doi = {10.1093/sleep/zsab076}, pmid = {33769542}, url = {https://doi.org/10.1093/sleep/zsab076} } @article{thorpe2012-22683399, author = {Thorpe, J. M. and Thorpe, C. T. and Kennelty, K. A. and Gellad, W. F. and Schulz, R.}, title = {{The impact of family caregivers on potentially inappropriate medication use in noninstitutionalized older adults with dementia}}, journal = {The American journal of geriatric pharmacotherapy}, year = {2012}, doi = {10.1016/j.amjopharm.2012.05.001}, pmid = {22683399}, url = {https://doi.org/10.1016/j.amjopharm.2012.05.001} } @article{andersen2011-21970467, author = {Andersen, F. and Viitanen, M. and Halvorsen, D. S. and Straume, B. and Engstad, T. A.}, title = {{Co-morbidity and drug treatment in Alzheimer's disease. A cross sectional study of participants in the dementia study in northern Norway}}, journal = {BMC geriatrics}, year = {2011}, doi = {10.1186/1471-2318-11-58}, pmid = {21970467}, url = {https://doi.org/10.1186/1471-2318-11-58} } @article{monahan2017-28790177, author = {Monahan, Z. and Ryan, V. H. and Janke, A. M. and Burke, K. A. and Rhoads, S. N. and Zerze, G. H. and O'Meally, R. and Dignon, G. L. and others}, title = {{Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity}}, journal = {The EMBO journal}, year = {2017}, doi = {10.15252/embj.201696394}, pmid = {28790177}, url = {https://doi.org/10.15252/embj.201696394} } @article{li2021-34589742, author = {Li, Q. S. and De Muynck, L.}, title = {{Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1}}, journal = {Brain, behavior, \& immunity - health}, year = {2021}, doi = {10.1016/j.bbih.2021.100227}, pmid = {34589742}, url = {https://doi.org/10.1016/j.bbih.2021.100227} } @article{karran2022-35177833, author = {Karran, E. and De Strooper, B.}, title = {{The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics}}, journal = {Nature reviews. Drug discovery}, year = {2022}, doi = {10.1038/s41573-022-00391-w}, pmid = {35177833}, url = {https://doi.org/10.1038/s41573-022-00391-w} } @article{gaugler2013-24354549, author = {Gaugler, J. E. and Ascher-Svanum, H. and Roth, D. L. and Fafowora, T. and Siderowf, A. and Beach, T. G.}, title = {{Characteristics of patients misdiagnosed with Alzheimer's disease and their medication use: an analysis of the NACC-UDS database}}, journal = {BMC geriatrics}, year = {2013}, doi = {10.1186/1471-2318-13-137}, pmid = {24354549}, url = {https://doi.org/10.1186/1471-2318-13-137} } @article{whitmer2011-21280086, author = {Whitmer, R. A. and Quesenberry, C. P. and Zhou, J. and Yaffe, K.}, title = {{Timing of hormone therapy and dementia: the critical window theory revisited}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22239}, pmid = {21280086}, url = {https://doi.org/10.1002/ana.22239} } @article{chu2025-39775804, author = {Chu, Chenyin and Wang, Yifei and Wang, Yihan and Fowler, Christopher James and Zisis, Georgios and Masters, Colin Louis and Doecke, James D. and Goudey, Benjamin and others}, title = {{Development and Validation of a Tool to Predict Onset of Mild Cognitive Impairment and Alzheimer Dementia}}, journal = {JAMA Network Open}, year = {2025}, doi = {10.1001/jamanetworkopen.2024.53756}, pmid = {39775804}, url = {https://doi.org/10.1001/jamanetworkopen.2024.53756} } @article{hofe2025-40040336, author = {Hofe, Ilse vom and Stricker, Bruno H. Ch. and Ikram, Muhammad Aimen and Ikram, M. Kamran and Wolters, Frank J. and Ikram, M. Arfan}, title = {{Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk}}, journal = {Journal of the American Geriatrics Society}, year = {2025}, doi = {10.1111/jgs.19411}, pmid = {40040336}, url = {https://doi.org/10.1111/jgs.19411} } @article{menon2025-39935341, author = {Menon, Jayakumar and Kantipudi, Suvarna Jyothi and Vinoth, Stanley and Kuchipudi, Jyothsna Devi}, title = {{Prevalence of subjective cognitive decline and its association with physical health problems among urban community dwelling elderly population in South India}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.14505}, pmid = {39935341}, url = {https://doi.org/10.1002/alz.14505} } @article{therriault2024-38429551, author = {Therriault, J. and Schindler, S. E. and Salvadó, G. and Pascoal, T. A. and Benedet, A. L. and Ashton, N. J. and Karikari, T. K. and Apostolova, L. and others}, title = {{Biomarker-based staging of Alzheimer disease: rationale and clinical applications}}, journal = {Nature reviews. Neurology}, year = {2024}, doi = {10.1038/s41582-024-00942-2}, pmid = {38429551}, url = {https://doi.org/10.1038/s41582-024-00942-2} } @article{jutten2021-34550903, author = {Jutten, R. J. and Sikkes, S. A. M. and Van der Flier, W. M. and Scheltens, P. and Visser, P. J. and Tijms, B. M. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012022}, pmid = {34550903}, url = {https://doi.org/10.1212/wnl.0000000000012022} } @article{liu2013-23296339, author = {Liu, C. C. and Kanekiyo, T. and Xu, H. and Bu, G.}, title = {{Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy}}, journal = {Nature reviews. Neurology}, year = {2013}, doi = {10.1038/nrneurol.2012.263}, pmid = {23296339}, url = {https://doi.org/10.1038/nrneurol.2012.263} } @article{henderson2014-23727128, author = {Henderson, V. W.}, title = {{Alzheimer's disease: review of hormone therapy trials and implications for treatment and prevention after menopause}}, journal = {The Journal of steroid biochemistry and molecular biology}, year = {2014}, doi = {10.1016/j.jsbmb.2013.05.010}, pmid = {23727128}, url = {https://doi.org/10.1016/j.jsbmb.2013.05.010} } @article{roman2010-20395618, author = {Román, G. C. and Salloway, S. and Black, S. E. and Royall, D. R. and Decarli, C. and Weiner, M. W. and Moline, M. and Kumar, D. and others}, title = {{Randomized, placebo-controlled, clinical trial of donepezil in vascular dementia: differential effects by hippocampal size}}, journal = {Stroke}, year = {2010}, doi = {10.1161/strokeaha.109.570077}, pmid = {20395618}, url = {https://doi.org/10.1161/strokeaha.109.570077} } @article{jyvakorpi2012-22624652, author = {Jyvakorpi, S. K. and Puranen, T. and Pitkala, K. H. and Suominen, M. H.}, title = {{Nutritional treatment of aged individuals with Alzheimer disease living at home with their spouses: study protocol for a randomized controlled trial}}, journal = {Trials}, year = {2012}, doi = {10.1186/1745-6215-13-66}, pmid = {22624652}, url = {https://doi.org/10.1186/1745-6215-13-66} } @article{caramelli2014-24964105, author = {Caramelli, P. and Laks, J. and Palmini, A. L. and Nitrini, R. and Chaves, M. L. and Forlenza, O. V. and Vale Fde, A. and Barbosa, M. T. and others}, title = {{Effects of galantamine and galantamine combined with nimodipine on cognitive speed and quality of life in mixed dementia: a 24-week, randomized, placebo-controlled exploratory trial (the REMIX study)}}, journal = {Arquivos de neuro-psiquiatria}, year = {2014}, doi = {10.1590/0004-282x20140055}, pmid = {24964105}, url = {https://doi.org/10.1590/0004-282x20140055} } @article{mcmanus2022-35220356, author = {McManus, K. R. and Lapid, M. I. and Forester, B. P. and Mueller, M. and Hermida, A. P. and Nykamp, L. and Harper, D. G. and Seiner, S. J. and others}, title = {{Simulated Electroconvulsive Therapy: A Novel Approach to a Control Group in Clinical Trials}}, journal = {The journal of ECT}, year = {2022}, doi = {10.1097/yct.0000000000000832}, pmid = {35220356}, url = {https://doi.org/10.1097/yct.0000000000000832} } @article{deture2019-31375134, author = {DeTure, M. A. and Dickson, D. W.}, title = {{The neuropathological diagnosis of Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-019-0333-5}, pmid = {31375134}, url = {https://doi.org/10.1186/s13024-019-0333-5} } @article{frisoni2010-20139996, author = {Frisoni, G. B. and Fox, N. C. and Jack, C. R. and Scheltens, P. and Thompson, P. M.}, title = {{The clinical use of structural MRI in Alzheimer disease}}, journal = {Nature reviews. Neurology}, year = {2010}, doi = {10.1038/nrneurol.2009.215}, pmid = {20139996}, url = {https://doi.org/10.1038/nrneurol.2009.215} } @article{weller2018-30135715, author = {Weller, J. and Budson, A.}, title = {{Current understanding of Alzheimer's disease diagnosis and treatment}}, journal = {F1000Research}, year = {2018}, doi = {10.12688/f1000research.14506.1}, pmid = {30135715}, url = {https://doi.org/10.12688/f1000research.14506.1} } @article{murley2018-29373632, author = {Murley, A. G. and Rowe, J. B.}, title = {{Neurotransmitter deficits from frontotemporal lobar degeneration}}, journal = {Brain : a journal of neurology}, year = {2018}, doi = {10.1093/brain/awx327}, pmid = {29373632}, url = {https://doi.org/10.1093/brain/awx327} } @article{mcarthur2004-15534180, author = {McArthur, J. C. and McDermott, M. P. and McClernon, D. and St Hillaire, C. and Conant, K. and Marder, K. and Schifitto, G. and Selnes, O. A. and others}, title = {{Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy}}, journal = {Archives of neurology}, year = {2004}, doi = {10.1001/archneur.61.11.1687}, pmid = {15534180}, url = {https://doi.org/10.1001/archneur.61.11.1687} } @article{mamo2018-30304320, author = {Mamo, S. K. and Reed, N. S. and Price, C. and Occhipinti, D. and Pletnikova, A. and Lin, F. R. and Oh, E. S.}, title = {{Hearing Loss Treatment in Older Adults With Cognitive Impairment: A Systematic Review}}, journal = {Journal of speech, language, and hearing research : JSLHR}, year = {2018}, doi = {10.1044/2018_jslhr-h-18-0077}, pmid = {30304320}, url = {https://doi.org/10.1044/2018_jslhr-h-18-0077} } @article{zammit2026-41240365, author = {Zammit, M. D. and Bruzzone, H. and Cody, K. A. and Morse, J. and Wilson, R. and Bettcher, B. T. and McLachlan, M. J. and McVea, A. K. and others}, title = {{The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2026}, doi = {10.1093/brain/awaf428}, pmid = {41240365}, url = {https://doi.org/10.1093/brain/awaf428} } @article{reinhart2019-30962628, author = {Reinhart, R. M. G. and Nguyen, J. A.}, title = {{Working memory revived in older adults by synchronizing rhythmic brain circuits}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-019-0371-x}, pmid = {30962628}, url = {https://doi.org/10.1038/s41593-019-0371-x} } @article{toledo2017-28341160, author = {Toledo, J. B. and Arnold, M. and Kastenmüller, G. and Chang, R. and Baillie, R. A. and Han, X. and Thambisetty, M. and Tenenbaum, J. D. and others}, title = {{Metabolic network failures in Alzheimer's disease: A biochemical road map}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2017.01.020}, pmid = {28341160}, url = {https://doi.org/10.1016/j.jalz.2017.01.020} } @article{rohatgi2025-41038644, author = {Rohatgi, Saurabh and Zhu, Shenghua and Calle, Esteban and Ford, Jeremy N. and Kozak, Benjamin M. and Chagui, Odette Ganem and Vejdani‐Jahromi, Maryam and Griffin, Harry R. and others}, title = {{Are Deep White Matter Hyperintensities Associated with Amyloid-Related Imaging Abnormalities in Patients with Alzheimer Disease Treated with Lecanemab?}}, journal = {American Journal of Neuroradiology}, year = {2025}, doi = {10.3174/ajnr.a8822}, pmid = {41038644}, url = {https://doi.org/10.3174/ajnr.a8822} } @article{kenichiro2025-41114448, author = {Kenichiro, Sato and Yoshiki, Niimi and Ryoko, Ihara and Atsushi, Iwata and Kiyotaka, Nemoto and Tetsuaki, Arai and Shinji, Higashi and Ataru, Igarashi and others}, title = {{Real-world lecanemab adoption in Japan 1 year after launch: Insights from 311 specialists on infrastructure and reimbursement barriers}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70652}, pmid = {41114448}, url = {https://doi.org/10.1002/alz.70652} } @article{yeon2025-40696527, author = {Yeon, Jeon So and Sheng-Min, Wang and Woong, Roh Hyun and You, Kim Keun and Young, Chang Yoon and Eosu, Kim and Jae-Nam, Bae and Seung-Ho, Ryu}, title = {{Practical Guide of the Korean Association for Geriatric Psychiatry to Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer's Disease: Focused on Lecanemab}}, journal = {Journal of Korean medical science}, year = {2025}, doi = {10.3346/jkms.2025.40.e215}, pmid = {40696527}, url = {https://doi.org/10.3346/jkms.2025.40.e215} } @article{corralizagomez2025-41146261, author = {Corraliza-Gomez, M. and Vargas-Soria, M. and Garcia-Alloza, M.}, title = {{Effect of antidiabetic drugs in Alzheimer´s disease: a systematic review of preclinical and clinical studies}}, journal = {Molecular neurodegeneration}, year = {2025}, doi = {10.1186/s13024-025-00894-1}, pmid = {41146261}, url = {https://doi.org/10.1186/s13024-025-00894-1} } @article{wisch2021-32520734, author = {Wisch, J. K. and Meeker, K. L. and Gordon, B. A. and Flores, S. and Dincer, A. and Grant, E. A. and Benzinger, T. L. and Morris, J. C. and others}, title = {{Sex-related Differences in Tau Positron Emission Tomography (PET) and the Effects of Hormone Therapy (HT)}}, journal = {Alzheimer disease and associated disorders}, year = {2021}, doi = {10.1097/wad.0000000000000393}, pmid = {32520734}, url = {https://doi.org/10.1097/wad.0000000000000393} } @article{disalvo2018-30106321, author = {Disalvo, D. and Luckett, T. and Luscombe, G. and Bennett, A. and Davidson, P. and Chenoweth, L. and Mitchell, G. and Pond, D. and others}, title = {{Potentially Inappropriate Prescribing in Australian Nursing Home Residents with Advanced Dementia: A Substudy of the IDEAL Study}}, journal = {Journal of palliative medicine}, year = {2018}, doi = {10.1089/jpm.2018.0070}, pmid = {30106321}, url = {https://doi.org/10.1089/jpm.2018.0070} } @article{kile2021-34362303, author = {Kile, S. and Au, W. and Parise, C. and Rose, K. and Donnel, T. and Hankins, A. and Au, Y. and Chan, M. and others}, title = {{Five-year outcomes after IVIG for mild cognitive impairment due to alzheimer disease}}, journal = {BMC neuroscience}, year = {2021}, doi = {10.1186/s12868-021-00651-2}, pmid = {34362303}, url = {https://doi.org/10.1186/s12868-021-00651-2} } @article{tahamimonfared2022-35286590, author = {Tahami Monfared, A. A. and Byrnes, M. J. and White, L. A. and Zhang, Q.}, title = {{Alzheimer's Disease: Epidemiology and Clinical Progression}}, journal = {Neurology and therapy}, year = {2022}, doi = {10.1007/s40120-022-00338-8}, pmid = {35286590}, url = {https://doi.org/10.1007/s40120-022-00338-8} } @article{blennow2015-24795085, author = {Blennow, K. and Dubois, B. and Fagan, A. M. and Lewczuk, P. and de Leon, M. J. and Hampel, H.}, title = {{Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2014.02.004}, pmid = {24795085}, url = {https://doi.org/10.1016/j.jalz.2014.02.004} } @article{gonzalezortiz2023-36927491, author = {Gonzalez-Ortiz, F. and Kac, P. R. and Brum, W. S. and Zetterberg, H. and Blennow, K. and Karikari, T. K.}, title = {{Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications}}, journal = {Molecular neurodegeneration}, year = {2023}, doi = {10.1186/s13024-023-00605-8}, pmid = {36927491}, url = {https://doi.org/10.1186/s13024-023-00605-8} } @article{williamson2020-32584926, author = {Williamson, T. and Ryser, M. D. and Ubel, P. A. and Abdelgadir, J. and Spears, C. A. and Liu, B. and Komisarow, J. and Lemmon, M. E. and others}, title = {{Withdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury}}, journal = {JAMA surgery}, year = {2020}, doi = {10.1001/jamasurg.2020.1790}, pmid = {32584926}, url = {https://doi.org/10.1001/jamasurg.2020.1790} } @article{cioltan2017-28122506, author = {Cioltan, H. and Alshehri, S. and Howe, C. and Lee, J. and Fain, M. and Eng, H. and Schachter, K. and Mohler, J.}, title = {{Variation in use of antipsychotic medications in nursing homes in the United States: A systematic review}}, journal = {BMC geriatrics}, year = {2017}, doi = {10.1186/s12877-017-0428-1}, pmid = {28122506}, url = {https://doi.org/10.1186/s12877-017-0428-1} } @article{miglis2021-34302789, author = {Miglis, M. G. and Adler, C. H. and Antelmi, E. and Arnaldi, D. and Baldelli, L. and Boeve, B. F. and Cesari, M. and Dall'Antonia, I. and others}, title = {{Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder}}, journal = {The Lancet. Neurology}, year = {2021}, doi = {10.1016/s1474-4422(21)00176-9}, pmid = {34302789}, url = {https://doi.org/10.1016/s1474-4422(21)00176-9} } @article{deczkowska2020-32531244, author = {Deczkowska, A. and Weiner, A. and Amit, I.}, title = {{The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway}}, journal = {Cell}, year = {2020}, doi = {10.1016/j.cell.2020.05.003}, pmid = {32531244}, url = {https://doi.org/10.1016/j.cell.2020.05.003} } @article{silveira2019-30738426, author = {Silveira, C. R. A. and MacKinley, J. and Coleman, K. and Li, Z. and Finger, E. and Bartha, R. and Morrow, S. A. and Wells, J. and others}, title = {{Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial}}, journal = {BMC neurology}, year = {2019}, doi = {10.1186/s12883-019-1252-3}, pmid = {30738426}, url = {https://doi.org/10.1186/s12883-019-1252-3} } @article{nasir2026-42636218, author = {Nasir, Ahmad Basil and Kilani, Yassine and Aldiabat, Mohammad and Abdelghany, Omar and Hafez, Youssef and Desai, Nitin and Madi, Mahmoud Y. and Wade, Francis G. and others}, title = {{Antidiabetic medications and risk of cognitive disorders in type 2 diabetes: A retrospective cohort study}}, journal = {PLoS ONE}, year = {2026}, doi = {10.1371/journal.pone.0356138}, pmid = {42636218}, url = {https://doi.org/10.1371/journal.pone.0356138} } @article{chen2026-41785364, author = {Chen, Yun and Liu, Yizhou A. and Nguyen, Khai M. and Wu, Junjie and Song, Sihui and Lin, Kent and Rodrigues, Patrick Fernandes and Du, Siling and others}, title = {{Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy}}, journal = {Science}, year = {2026}, doi = {10.1126/science.ads3972}, pmid = {41785364}, url = {https://doi.org/10.1126/science.ads3972} } @article{barroeta2025-40528298, author = {Barroeta, Isabel and Videla, Laura and Carmona‐Iragui, María and Fortea, Juan and Rafii, Michael S.}, title = {{Current advances and unmet needs in Alzheimer's disease trials for individuals with Down syndrome: Navigating new therapeutic frontiers}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70258}, pmid = {40528298}, url = {https://doi.org/10.1002/alz.70258} } @article{sperling2011-21784348, author = {Sperling, Reisa Anne and Jack, Clifford R. and Black, Sandra E. and Frosch, Matthew P. and Greenberg, Steven Mark and Hyman, Bradley T. and Scheltens, Philip and Carrillo, María C. and Thies, William H. and Bednar, Martin M. and Black, Ronald S. and Brashear, H. Robert and Grundman, Michael and Siemers, Eric and Feldman, Howard and Schindler, Rachel J.}, title = {{Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup}}, journal = {Alzheimer s \& Dementia}, year = {2011}, doi = {10.1016/j.jalz.2011.05.2351}, pmid = {21784348}, url = {https://doi.org/10.1016/j.jalz.2011.05.2351} } @article{collins2026-42565262, author = {Collins, E. C. and Lu, M. and Beck, R. and Hendrix, J. and Hodsdon, M. E. and Hansson, O.}, title = {{Plasma P-tau217 for detecting amyloid clearance after donanemab in Alzheimer's disease}}, journal = {Alzheimer's \& Dementia}, year = {2026}, doi = {10.1002/alz.71740}, pmid = {42565262}, url = {https://doi.org/10.1002/alz.71740} } @article{albertini2026-41286448, author = {Albertini, G. and Zielonka, M. and Cuypers, M. L. and Snellinx, A. and Xu, C. and Poovathingal, S. and Wojno, M. and Davie, K. and van Lieshout, V. and Craessaerts, K. and Wolfs, L. and Pasciuto, E. and others}, title = {{The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia}}, journal = {Nature Neuroscience}, year = {2026}, doi = {10.1038/s41593-025-02125-8}, pmid = {41286448}, url = {https://doi.org/10.1038/s41593-025-02125-8} } @article{peters2016-26303700, author = {Peters, M. E. and Vaidya, V. and Drye, L. T. and Devanand, D. P. and Mintzer, J. E. and Pollock, B. G. and Porsteinsson, A. P. and Rosenberg, P. B. and others}, title = {{Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences}}, journal = {Journal of geriatric psychiatry and neurology}, year = {2016}, doi = {10.1177/0891988715601735}, pmid = {26303700}, url = {https://doi.org/10.1177/0891988715601735} } @article{li2017-29390538, author = {Li, M. and Lyu, J. H. and Zhang, Y. and Gao, M. L. and Li, W. J. and Ma, X.}, title = {{The clinical efficacy of reminiscence therapy in patients with mild-to-moderate Alzheimer disease: Study protocol for a randomized parallel-design controlled trial}}, journal = {Medicine}, year = {2017}, doi = {10.1097/md.0000000000009381}, pmid = {29390538}, url = {https://doi.org/10.1097/md.0000000000009381} } @article{jeong2021-34664858, author = {Jeong, J. H. and Jung, C. and Kim, J. and Kim, J. Y. and Kim, H. S. and Park, Y. C. and Lee, J. H. and Jung, I. C.}, title = {{Investigation of combined treatment of acupuncture and neurofeedback for improving cognitive function in mild neurocognitive disorder: A randomized, assessor-blind, pilot study}}, journal = {Medicine}, year = {2021}, doi = {10.1097/md.0000000000027218}, pmid = {34664858}, url = {https://doi.org/10.1097/md.0000000000027218} } @article{ismail2020-32725777, author = {Ismail, Z. and Black, S. E. and Camicioli, R. and Chertkow, H. and Herrmann, N. and Laforce, R. and Montero-Odasso, M. and Rockwood, K. and others}, title = {{Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2020}, doi = {10.1002/alz.12105}, pmid = {32725777}, url = {https://doi.org/10.1002/alz.12105} } @article{sierksma2020-33004512, author = {Sierksma, A. and Escott-Price, V. and De Strooper, B.}, title = {{Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets}}, journal = {Science (New York, N.Y.)}, year = {2020}, doi = {10.1126/science.abb8575}, pmid = {33004512}, url = {https://doi.org/10.1126/science.abb8575} } @article{herzog2025-40887468, author = {Herzog, M. J. and Müller, P. and Lechner, K. and Stiebler, M. and Arndt, P. and Kunz, M. and Ahrens, D. and Schmeißer, A. and others}, title = {{Arterial stiffness and vascular aging: mechanisms, prevention, and therapy}}, journal = {Signal transduction and targeted therapy}, year = {2025}, doi = {10.1038/s41392-025-02346-0}, pmid = {40887468}, url = {https://doi.org/10.1038/s41392-025-02346-0} } @article{cummings2018-29955663, author = {Cummings, J. and Lee, G. and Ritter, A. and Zhong, K.}, title = {{Alzheimer's disease drug development pipeline: 2018}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2018}, doi = {10.1016/j.trci.2018.03.009}, pmid = {29955663}, url = {https://doi.org/10.1016/j.trci.2018.03.009} } @article{gibbons2017-28050656, author = {Gibbons, C. H. and Schmidt, P. and Biaggioni, I. and Frazier-Mills, C. and Freeman, R. and Isaacson, S. and Karabin, B. and Kuritzky, L. and others}, title = {{The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension}}, journal = {Journal of neurology}, year = {2017}, doi = {10.1007/s00415-016-8375-x}, pmid = {28050656}, url = {https://doi.org/10.1007/s00415-016-8375-x} } @article{ross2022-35344024, author = {Ross, E. L. and Weinberg, M. S. and Arnold, S. E.}, title = {{Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.0315}, pmid = {35344024}, url = {https://doi.org/10.1001/jamaneurol.2022.0315} } @article{ajoolabady2022-35970828, author = {Ajoolabady, A. and Lindholm, D. and Ren, J. and Pratico, D.}, title = {{ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments}}, journal = {Cell death \& disease}, year = {2022}, doi = {10.1038/s41419-022-05153-5}, pmid = {35970828}, url = {https://doi.org/10.1038/s41419-022-05153-5} } @article{pemberton2022-35389071, author = {Pemberton, H. G. and Collij, L. E. and Heeman, F. and Bollack, A. and Shekari, M. and Salvadó, G. and Alves, I. L. and Garcia, D. V. and others}, title = {{Quantification of amyloid PET for future clinical use: a state-of-the-art review}}, journal = {European journal of nuclear medicine and molecular imaging}, year = {2022}, doi = {10.1007/s00259-022-05784-y}, pmid = {35389071}, url = {https://doi.org/10.1007/s00259-022-05784-y} } @article{raulin2022-36348357, author = {Raulin, A. C. and Doss, S. V. and Trottier, Z. A. and Ikezu, T. C. and Bu, G. and Liu, C. C.}, title = {{ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies}}, journal = {Molecular neurodegeneration}, year = {2022}, doi = {10.1186/s13024-022-00574-4}, pmid = {36348357}, url = {https://doi.org/10.1186/s13024-022-00574-4} } @article{tzeng2022-36212036, author = {Tzeng, R. C. and Yang, Y. W. and Hsu, K. C. and Chang, H. T. and Chiu, P. Y.}, title = {{Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages}}, journal = {Frontiers in aging neuroscience}, year = {2022}, doi = {10.3389/fnagi.2022.1021792}, pmid = {36212036}, url = {https://doi.org/10.3389/fnagi.2022.1021792} } @article{lashuel2013-23254192, author = {Lashuel, H. A. and Overk, C. R. and Oueslati, A. and Masliah, E.}, title = {{The many faces of α-synuclein: from structure and toxicity to therapeutic target}}, journal = {Nature reviews. Neuroscience}, year = {2013}, doi = {10.1038/nrn3406}, pmid = {23254192}, url = {https://doi.org/10.1038/nrn3406} } @article{brown2026-42437499, author = {Brown, C. A. and Robinson, J. L. and Das, SR. and McGrew, E. and Suh, E. and Van Deerlin, V. M. and Irwin, D. J. and Nasrallah, I. M. and others}, title = {{Clinicopathologic Evaluation of Amyloid Clearance in Alzheimer Disease}}, journal = {JAMA}, year = {2026}, doi = {10.1001/jama.2026.13058}, pmid = {42437499}, url = {https://doi.org/10.1001/jama.2026.13058} } @article{chen2023-37452321, author = {Chen, Y. and Yu, Y.}, title = {{Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation}}, journal = {Journal of neuroinflammation}, year = {2023}, doi = {10.1186/s12974-023-02853-3}, pmid = {37452321}, url = {https://doi.org/10.1186/s12974-023-02853-3} } @article{luchristt2023-37223899, author = {Luchristt, Douglas and Bretschneider, Carol Emi and Kenton, Kimberly Sue and Simon, Melissa Andrea and Brown, Oluwateniola}, title = {{Inequities in Filled Overactive Bladder Medication Prescriptions in the US}}, journal = {JAMA Network Open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.15074}, pmid = {37223899}, url = {https://doi.org/10.1001/jamanetworkopen.2023.15074} } @article{biel2025-41126448, author = {Biel, Davina and Steward, Anna and Dewenter, Anna and Dehsarvi, Amir and Zhu, Zeyu and Roemer, Sebastian Niclas and Frontzkowski, Lukas K. and Hirsch, Fabian and others}, title = {{A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70783}, pmid = {41126448}, url = {https://doi.org/10.1002/alz.70783} } @article{jang2026-41682879, author = {Jang, Yoo Jin and Chang, June Ho and Moon, Daa Un and Jeon, Hong Jin}, title = {{Cognitive Impairment, Dementia and Depression in Older Adults}}, journal = {Journal of Clinical Medicine}, year = {2026}, doi = {10.3390/jcm15031198}, pmid = {41682879}, url = {https://doi.org/10.3390/jcm15031198} } @article{weidmann2025-40686036, author = {Weidmann, Anita Elaine and Matthíasdóttir, Rut and Proppé, Guðný Björk and Tadić, Ivana and Gunnarsson, Pétur and Jónsdóttir, Freyja}, title = {{Medication Causes and Treatment of Delirium in Patients With and Without Dementia}}, journal = {Brain and Behavior}, year = {2025}, doi = {10.1002/brb3.70706}, pmid = {40686036}, url = {https://doi.org/10.1002/brb3.70706} } @article{johnson2026-41617706, author = {Johnson, L. A. and Saito, K. and Pallerla, A. V. and Funnell, J. L. and Ezzo, A. R. and Song, C. M. and Harrison, D. A. and Norton, N. J. and Moore, L. C. and Van Eldik, L. J. and others}, title = {{Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA}}, journal = {Nature Communications}, year = {2026}, doi = {10.1038/s41467-026-68921-3}, pmid = {41617706}, url = {https://doi.org/10.1038/s41467-026-68921-3} } @article{lee2020-32872063, author = {Lee, J. and Jin, C. and Cho, S. Y. and Park, S. U. and Jung, W. S. and Moon, S. K. and Park, J. M. and Ko, C. N. and others}, title = {{Herbal medicine treatment for Alzheimer disease: A protocol for a systematic review and meta-analysis}}, journal = {Medicine}, year = {2020}, doi = {10.1097/md.0000000000021745}, pmid = {32872063}, url = {https://doi.org/10.1097/md.0000000000021745} } @article{bloniecki2017-28269767, author = {Bloniecki, V. and Aarsland, D. and Blennow, K. and Cummings, J. and Falahati, F. and Winblad, B. and Freund-Levi, Y.}, title = {{Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-160758}, pmid = {28269767}, url = {https://doi.org/10.3233/jad-160758} } @article{sun2012-25657666, author = {Sun, Y. and Wang, G. and Pan, Z. and Chen, S.}, title = {{Systematic review of atorvastatin for the treatment of Alzheimer's disease}}, journal = {Neural regeneration research}, year = {2012}, doi = {10.3969/j.issn.1673-5374.2012.17.010}, pmid = {25657666}, url = {https://doi.org/10.3969/j.issn.1673-5374.2012.17.010} } @article{delarosa2020-32780691, author = {De la Rosa, A. and Olaso-Gonzalez, G. and Arc-Chagnaud, C. and Millan, F. and Salvador-Pascual, A. and García-Lucerga, C. and Blasco-Lafarga, C. and Garcia-Dominguez, E. and others}, title = {{Physical exercise in the prevention and treatment of Alzheimer's disease}}, journal = {Journal of sport and health science}, year = {2020}, doi = {10.1016/j.jshs.2020.01.004}, pmid = {32780691}, url = {https://doi.org/10.1016/j.jshs.2020.01.004} } @article{alexopoulos2019-31383842, author = {Alexopoulos, G. S.}, title = {{Mechanisms and treatment of late-life depression}}, journal = {Translational psychiatry}, year = {2019}, doi = {10.1038/s41398-019-0514-6}, pmid = {31383842}, url = {https://doi.org/10.1038/s41398-019-0514-6} } @article{zheng2025-38733347, author = {Zheng, Q. and Wang, X.}, title = {{Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy}}, journal = {Protein \& cell}, year = {2025}, doi = {10.1093/procel/pwae026}, pmid = {38733347}, url = {https://doi.org/10.1093/procel/pwae026} } @article{study2017-29234814, author = {{US Preventive Services Task Force} and Grossman, D. C. and Curry, S. J. and Owens, D. K. and Barry, M. J. and Davidson, K. W. and Doubeni, C. A. and Epling, J. W. and others}, title = {{Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: US Preventive Services Task Force Recommendation Statement}}, journal = {JAMA}, year = {2017}, doi = {10.1001/jama.2017.18261}, pmid = {29234814}, url = {https://doi.org/10.1001/jama.2017.18261} } @article{safiri2024-39736972, author = {Safiri, S. and Ghaffari Jolfayi, A. and Fazlollahi, A. and Morsali, S. and Sarkesh, A. and Daei Sorkhabi, A. and Golabi, B. and Aletaha, R. and others}, title = {{Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges}}, journal = {Frontiers in medicine}, year = {2024}, doi = {10.3389/fmed.2024.1474043}, pmid = {39736972}, url = {https://doi.org/10.3389/fmed.2024.1474043} } @article{twarowski2023-37047492, author = {Twarowski, B. and Herbet, M.}, title = {{Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review}}, journal = {International journal of molecular sciences}, year = {2023}, doi = {10.3390/ijms24076518}, pmid = {37047492}, url = {https://doi.org/10.3390/ijms24076518} } @article{carriere2009-19636034, author = {Carrière, I. and Fourrier-Reglat, A. and Dartigues, J. F. and Rouaud, O. and Pasquier, F. and Ritchie, K. and Ancelin, M. L.}, title = {{Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study}}, journal = {Archives of internal medicine}, year = {2009}, doi = {10.1001/archinternmed.2009.229}, pmid = {19636034}, url = {https://doi.org/10.1001/archinternmed.2009.229} } @article{halliday2017-28430857, author = {Halliday, M. and Radford, H. and Zents, K. A. M. and Molloy, C. and Moreno, J. A. and Verity, N. C. and Smith, E. and Ortori, C. A. and others}, title = {{Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice}}, journal = {Brain : a journal of neurology}, year = {2017}, doi = {10.1093/brain/awx074}, pmid = {28430857}, url = {https://doi.org/10.1093/brain/awx074} } @article{pedersen2015-26606383, author = {Pedersen, B. K. and Saltin, B.}, title = {{Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases}}, journal = {Scandinavian journal of medicine \& science in sports}, year = {2015}, doi = {10.1111/sms.12581}, pmid = {26606383}, url = {https://doi.org/10.1111/sms.12581} } @article{liu2024-39158850, author = {Liu, L. and Saba, A. and Pascual, JR. and Miller, M. B. and Hennessey, E. L. and Lott, I. T. and Brickman, A. M. and Wilcock, D. M. and others}, title = {{Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.2579}, pmid = {39158850}, url = {https://doi.org/10.1001/jamaneurol.2024.2579} } @article{lagiertourenne2013-24170860, author = {Lagier-Tourenne, C. and Baughn, M. and Rigo, F. and Sun, S. and Liu, P. and Li, H. R. and Jiang, J. and Watt, A. T. and others}, title = {{Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2013}, doi = {10.1073/pnas.1318835110}, pmid = {24170860}, url = {https://doi.org/10.1073/pnas.1318835110} } @article{cummings2023-37251912, author = {Cummings, J. and Zhou, Y. and Lee, G. and Zhong, K. and Fonseca, J. and Cheng, F.}, title = {{Alzheimer's disease drug development pipeline: 2023}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2023}, doi = {10.1002/trc2.12385}, pmid = {37251912}, url = {https://doi.org/10.1002/trc2.12385} } @article{sima2024-38345816, author = {Sima, D. M. and Phan, T. V. and Van Eyndhoven, S. and Vercruyssen, S. and Magalhães, R. and Liseune, A. and Brys, A. and Frenyo, P. and others}, title = {{Artificial Intelligence Assistive Software Tool for Automated Detection and Quantification of Amyloid-Related Imaging Abnormalities}}, journal = {JAMA network open}, year = {2024}, doi = {10.1001/jamanetworkopen.2023.55800}, pmid = {38345816}, url = {https://doi.org/10.1001/jamanetworkopen.2023.55800} } @article{han2019-30633043, author = {Han, J. Y. and Besser, L. M. and Xiong, C. and Kukull, W. A. and Morris, J. C.}, title = {{Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia}}, journal = {Alzheimer disease and associated disorders}, year = {2019}, doi = {10.1097/wad.0000000000000291}, pmid = {30633043}, url = {https://doi.org/10.1097/wad.0000000000000291} } @article{teipel2018-30158893, author = {Teipel, S. J. and Cavedo, E. and Hampel, H. and Grothe, M. J. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors}}, journal = {Frontiers in neurology}, year = {2018}, doi = {10.3389/fneur.2018.00642}, pmid = {30158893}, url = {https://doi.org/10.3389/fneur.2018.00642} } @article{rocca2011-20965156, author = {Rocca, W. A. and Grossardt, B. R. and Shuster, L. T.}, title = {{Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity}}, journal = {Brain research}, year = {2011}, doi = {10.1016/j.brainres.2010.10.031}, pmid = {20965156}, url = {https://doi.org/10.1016/j.brainres.2010.10.031} } @article{ackerman2023-36950931, author = {Ackerman, A. Lenore}, title = {{Penny-wise but Pound-foolish: The Hidden Costs of Step Therapy for Overactive Bladder}}, journal = {The Journal of Urology}, year = {2023}, doi = {10.1097/ju.0000000000003430}, pmid = {36950931}, url = {https://doi.org/10.1097/ju.0000000000003430} } @article{yin2023-37528774, author = {Yin, Christina Y and Windham, Beverly Gwen and Kucharska‐Newton, Anna and Couper, David J. and Lutsey, Pamela L. and Ballew, Shoshana H. and Shin, Jung‐Im}, title = {{Factors associated with medication adherence in older adults: The atherosclerosis risk in communities study}}, journal = {Journal of the American Geriatrics Society}, year = {2023}, doi = {10.1111/jgs.18537}, pmid = {37528774}, url = {https://doi.org/10.1111/jgs.18537} } @article{wang2025-40552638, author = {Wang, William and Davis, Pamela B. and Qi, Xin and Gurney, Mark E. and Perry, George and Volkow, Nora D. and Kaelber, David C. and Xu, Rong}, title = {{Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study}}, journal = {Journal of Alzheimer s Disease}, year = {2025}, doi = {10.1177/13872877251351329}, pmid = {40552638}, url = {https://doi.org/10.1177/13872877251351329} } @article{sondh2025-40483728, author = {Sondh, Harsharon Kaur and Bishara, Delia and Perera, Gayan and Shetty, Hitesh and Stewart, Robert and Mueller, Christoph S.}, title = {{Medications associated with dizziness or hypotension and adverse outcomes: an electronic health record study in older adults with dementia}}, journal = {Age and Ageing}, year = {2025}, doi = {10.1093/ageing/afaf154}, pmid = {40483728}, url = {https://doi.org/10.1093/ageing/afaf154} } @article{bradley2025-293e0750, author = {Bradley, Cathy J. and Liang, Rifei and Lindrooth, Richard C. and Sabik, Lindsay M. and Perraillon, Marcelo C.}, title = {{High-Cost Cancer Drug Use in Medicare Advantage and Traditional Medicare}}, journal = {JAMA Health Forum}, year = {2025}, doi = {10.1001/jamahealthforum.2024.4868}, url = {https://doi.org/10.1001/jamahealthforum.2024.4868} } @article{ishmuratova2023-37968954, author = {Ishmuratova, A. N. and Abramov, M. A. and Kuznetsov, K. O. and Ivanyuta, M. V. and Shakirova, Z. F. and Kitapova, A. I. and Usmonov, M. D. and Chernousova, L. M. and others}, title = {{[The role of antidiabetic drugs in the treatment of Alzheimer's disease: systematic review]}}, journal = {Problemy endokrinologii}, year = {2023}, doi = {10.14341/probl13183}, pmid = {37968954}, url = {https://doi.org/10.14341/probl13183} } @article{fulop2020-32458360, author = {Fülöp, T. and Munawara, U. and Larbi, A. and Desroches, M. and Rodrigues, S. and Catanzaro, M. and Guidolin, A. and Khalil, A. and others}, title = {{Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer's Disease}}, journal = {CNS drugs}, year = {2020}, doi = {10.1007/s40263-020-00737-1}, pmid = {32458360}, url = {https://doi.org/10.1007/s40263-020-00737-1} } @article{yang2026-42410659, author = {Yang, C. T. and Wilkins, J. M. and Kesselheim, A. S. and Kim, D. H. and Lin, K. J.}, title = {{Clinical outcomes after antipsychotic discontinuation in nursing home residents with dementia: a nationwide cohort study}}, journal = {Alzheimer's Research \& Therapy}, year = {2026}, doi = {10.1186/s13195-026-02134-0}, pmid = {42410659}, url = {https://doi.org/10.1186/s13195-026-02134-0} } @article{chapleau2022-35649652, author = {Chapleau, M. and Iaccarino, L. and Soleimani-Meigooni, D. and Rabinovici, G. D.}, title = {{The Role of Amyloid PET in Imaging Neurodegenerative Disorders: A Review}}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year = {2022}, doi = {10.2967/jnumed.121.263195}, pmid = {35649652}, url = {https://doi.org/10.2967/jnumed.121.263195} } @article{filip1999-10354658, author = {Filip, V. and Kolibás, E.}, title = {{Selegiline in the treatment of Alzheimer's disease: a long-term randomized placebo-controlled trial. Czech and Slovak Senile Dementia of Alzheimer Type Study Group}}, journal = {Journal of psychiatry \& neuroscience : JPN}, year = {1999}, pmid = {10354658} } @article{berres2021-33962665, author = {Berres, M. and Monsch, A. U. and Spiegel, R.}, title = {{Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00832-5}, pmid = {33962665}, url = {https://doi.org/10.1186/s13195-021-00832-5} } @article{viola2015-25604547, author = {Viola, K. L. and Klein, W. L.}, title = {{Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis}}, journal = {Acta neuropathologica}, year = {2015}, doi = {10.1007/s00401-015-1386-3}, pmid = {25604547}, url = {https://doi.org/10.1007/s00401-015-1386-3} } @article{knopman2014-25282431, author = {Knopman, D. S. and Petersen, R. C.}, title = {{Mild cognitive impairment and mild dementia: a clinical perspective}}, journal = {Mayo Clinic proceedings}, year = {2014}, doi = {10.1016/j.mayocp.2014.06.019}, pmid = {25282431}, url = {https://doi.org/10.1016/j.mayocp.2014.06.019} } @article{klunk2011-22078170, author = {Klunk, W. E.}, title = {{Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia}}, journal = {Neurobiology of aging}, year = {2011}, doi = {10.1016/j.neurobiolaging.2011.09.006}, pmid = {22078170}, url = {https://doi.org/10.1016/j.neurobiolaging.2011.09.006} } @article{cerejeira2012-22586419, author = {Cerejeira, J. and Lagarto, L. and Mukaetova-Ladinska, E. B.}, title = {{Behavioral and psychological symptoms of dementia}}, journal = {Frontiers in neurology}, year = {2012}, doi = {10.3389/fneur.2012.00073}, pmid = {22586419}, url = {https://doi.org/10.3389/fneur.2012.00073} } @article{yao2021-32048886, author = {Yao, R. Q. and Ren, C. and Xia, Z. F. and Yao, Y. M.}, title = {{Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles}}, journal = {Autophagy}, year = {2021}, doi = {10.1080/15548627.2020.1725377}, pmid = {32048886}, url = {https://doi.org/10.1080/15548627.2020.1725377} } @article{vassar2014-24646365, author = {Vassar, R. and Kuhn, P. H. and Haass, C. and Kennedy, M. E. and Rajendran, L. and Wong, P. C. and Lichtenthaler, S. F.}, title = {{Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects}}, journal = {Journal of neurochemistry}, year = {2014}, doi = {10.1111/jnc.12715}, pmid = {24646365}, url = {https://doi.org/10.1111/jnc.12715} } @article{lewcock2020-33096024, author = {Lewcock, J. W. and Schlepckow, K. and Di Paolo, G. and Tahirovic, S. and Monroe, K. M. and Haass, C.}, title = {{Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease}}, journal = {Neuron}, year = {2020}, doi = {10.1016/j.neuron.2020.09.029}, pmid = {33096024}, url = {https://doi.org/10.1016/j.neuron.2020.09.029} } @article{beckmann2018-29448957, author = {Beckmann, N. and Giorgetti, E. and Neuhaus, A. and Zurbruegg, S. and Accart, N. and Smith, P. and Perdoux, J. and Perrot, L. and others}, title = {{Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945}}, journal = {Acta neuropathologica communications}, year = {2018}, doi = {10.1186/s40478-018-0510-8}, pmid = {29448957}, url = {https://doi.org/10.1186/s40478-018-0510-8} } @article{huang2023-37784171, author = {Huang, L. K. and Kuan, Y. C. and Lin, H. W. and Hu, C. J.}, title = {{Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update}}, journal = {Journal of biomedical science}, year = {2023}, doi = {10.1186/s12929-023-00976-6}, pmid = {37784171}, url = {https://doi.org/10.1186/s12929-023-00976-6} } @article{huang2020-31906949, author = {Huang, L. K. and Chao, S. P. and Hu, C. J.}, title = {{Clinical trials of new drugs for Alzheimer disease}}, journal = {Journal of biomedical science}, year = {2020}, doi = {10.1186/s12929-019-0609-7}, pmid = {31906949}, url = {https://doi.org/10.1186/s12929-019-0609-7} } @article{raver2025-40227682, author = {Raver, Eli and Jung, Jeah Kyoungrae and Carlin, Caroline and Feldman, Roger D and Retchin, Sheldon M. and Xu, Wendy}, title = {{Racial and Ethnic Differences in Potentially Inappropriate Medication Use Among Medicare Beneficiaries}}, journal = {JAMA Network Open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.4763}, pmid = {40227682}, url = {https://doi.org/10.1001/jamanetworkopen.2025.4763} } @article{stefani2025-39934903, author = {Stefani, Ambra and Antelmi, Elena and Arnaldi, Dario and Arnulf, Isabelle and During, Emmanuel and Högl, Birgit and Hu, Michele M. T. and Iranzo, Alex and others}, title = {{From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease}}, journal = {Molecular Neurodegeneration}, year = {2025}, doi = {10.1186/s13024-025-00809-0}, pmid = {39934903}, url = {https://doi.org/10.1186/s13024-025-00809-0} } @article{sun2025-40695613, author = {Sun, Mingyang and Wang, Xiaoling and Lu, Zhongyuan and Yang, Yi and Lv, Shuang and Miao, Mengrong and Chen, Wanming and Wu, Szu‐Yuan and others}, title = {{Evaluating GLP-1 receptor agonists versus metformin as first-line therapy for reducing dementia risk in type 2 diabetes}}, journal = {BMJ Open Diabetes Research \& Care}, year = {2025}, doi = {10.1136/bmjdrc-2025-004902}, pmid = {40695613}, url = {https://doi.org/10.1136/bmjdrc-2025-004902} } @article{roach2025-41275266, author = {Roach, Jared C. and Glusman, Gwênlyn and Rapozo, Molly K. and Merrill, David A. and Bramen, Jennifer E. and Hodes, John F. and Siddarth, Prabha and Meysami, Somayeh and others}, title = {{Multidomain therapy for Alzheimer’s disease: a scoping review of cognitive decline trials}}, journal = {Molecular Neurodegeneration}, year = {2025}, doi = {10.1186/s13024-025-00912-2}, pmid = {41275266}, url = {https://doi.org/10.1186/s13024-025-00912-2} } @article{southerland2025-40485881, author = {Southerland, Lauren T. and Chesko, David M. and Arendts, Glenn and Kennedy, Maura and Liu, Shan W. and Lee, Sangil and Quadoura, Nadine and McLoughlin, Kara and others}, title = {{Outcomes of Physical and Occupational Therapy Evaluation in the Emergency Department for Older Adults With Falls: A Retrospective Multicenter Cohort}}, journal = {Journal of the American College of Emergency Physicians Open}, year = {2025}, doi = {10.1016/j.acepjo.2025.100141}, pmid = {40485881}, url = {https://doi.org/10.1016/j.acepjo.2025.100141} } @article{caro2025-41266628, author = {Caro, Ilana and Western, Daniel and Namba, Shinichi and Sun, Na and Kawaguchi, Shuji and He, Yunye and Fujita, Masashi and Roshchupkin, Gennady V. and others}, title = {{Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease}}, journal = {Nature Aging}, year = {2025}, doi = {10.1038/s43587-025-01006-w}, pmid = {41266628}, url = {https://doi.org/10.1038/s43587-025-01006-w} } @article{bingke2025-40489822, author = {Bingke, Xing and Jingran, Yang and Hui, Hua and Rong, Jiang}, title = {{Rapid health technology assessment of galantamine for the treatment of Alzheimer's disease: A review}}, journal = {Medicine}, year = {2025}, doi = {10.1097/MD.0000000000042744}, pmid = {40489822}, url = {https://doi.org/10.1097/MD.0000000000042744} } @article{poirier1995-8618881, author = {Poirier, J. and Delisle, M. C. and Quirion, R. and Aubert, I. and Farlow, M. and Lahiri, D. and Hui, S. and Bertrand, P. and others}, title = {{Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {1995}, doi = {10.1073/pnas.92.26.12260}, pmid = {8618881}, url = {https://doi.org/10.1073/pnas.92.26.12260} } @article{reisberg2017-28122366, author = {Reisberg, B. and Shao, Y. and Golomb, J. and Monteiro, I. and Torossian, C. and Boksay, I. and Shulman, M. and Heller, S. and others}, title = {{Comprehensive, Individualized, Person-Centered Management of Community-Residing Persons with Moderate-to-Severe Alzheimer Disease: A Randomized Controlled Trial}}, journal = {Dementia and geriatric cognitive disorders}, year = {2017}, doi = {10.1159/000455397}, pmid = {28122366}, url = {https://doi.org/10.1159/000455397} } @article{kales2014-24635665, author = {Kales, H. C. and Gitlin, L. N. and Lyketsos, C. G. and {Detroit Expert Panel on Assessment and Management of Neuropsychiatric Symptoms of Dementia}}, title = {{Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel}}, journal = {Journal of the American Geriatrics Society}, year = {2014}, doi = {10.1111/jgs.12730}, pmid = {24635665}, url = {https://doi.org/10.1111/jgs.12730} } @article{cook2020-32878979, author = {Cook, C. N. and Wu, Y. and Odeh, H. M. and Gendron, T. F. and Jansen-West, K. and Del Rosso, G. and Yue, M. and Jiang, P. and others}, title = {{C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy}}, journal = {Science translational medicine}, year = {2020}, doi = {10.1126/scitranslmed.abb3774}, pmid = {32878979}, url = {https://doi.org/10.1126/scitranslmed.abb3774} } @article{zucchella2018-30619031, author = {Zucchella, C. and Sinforiani, E. and Tamburin, S. and Federico, A. and Mantovani, E. and Bernini, S. and Casale, R. and Bartolo, M.}, title = {{The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment}}, journal = {Frontiers in neurology}, year = {2018}, doi = {10.3389/fneur.2018.01058}, pmid = {30619031}, url = {https://doi.org/10.3389/fneur.2018.01058} } @article{anderson2019-30651152, author = {Anderson, N. D.}, title = {{State of the science on mild cognitive impairment (MCI)}}, journal = {CNS spectrums}, year = {2019}, doi = {10.1017/s1092852918001347}, pmid = {30651152}, url = {https://doi.org/10.1017/s1092852918001347} } @article{destrooper2010-20139999, author = {De Strooper, B. and Vassar, R. and Golde, T.}, title = {{The secretases: enzymes with therapeutic potential in Alzheimer disease}}, journal = {Nature reviews. Neurology}, year = {2010}, doi = {10.1038/nrneurol.2009.218}, pmid = {20139999}, url = {https://doi.org/10.1038/nrneurol.2009.218} } @article{greig2005-16275899, author = {Greig, N. H. and Utsuki, T. and Ingram, D. K. and Wang, Y. and Pepeu, G. and Scali, C. and Yu, Q. S. and Mamczarz, J. and others}, title = {{Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2005}, doi = {10.1073/pnas.0508575102}, pmid = {16275899}, url = {https://doi.org/10.1073/pnas.0508575102} } @article{mcdade2021-34548654, author = {McDade, E. and Voytyuk, I. and Aisen, P. and Bateman, R. J. and Carrillo, M. C. and De Strooper, B. and Haass, C. and Reiman, E. M. and others}, title = {{The case for low-level BACE1 inhibition for the prevention of Alzheimer disease}}, journal = {Nature reviews. Neurology}, year = {2021}, doi = {10.1038/s41582-021-00545-1}, pmid = {34548654}, url = {https://doi.org/10.1038/s41582-021-00545-1} } @article{price2020-32795308, author = {Price, B. R. and Sudduth, T. L. and Weekman, E. M. and Johnson, S. and Hawthorne, D. and Woolums, A. and Wilcock, D. M.}, title = {{Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition}}, journal = {Journal of neuroinflammation}, year = {2020}, doi = {10.1186/s12974-020-01915-0}, pmid = {32795308}, url = {https://doi.org/10.1186/s12974-020-01915-0} } @article{ardighieri2021-34220848, author = {Ardighieri, L. and Missale, F. and Bugatti, M. and Gatta, L. B. and Pezzali, I. and Monti, M. and Gottardi, S. and Zanotti, L. and others}, title = {{Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes}}, journal = {Frontiers in immunology}, year = {2021}, doi = {10.3389/fimmu.2021.690201}, pmid = {34220848}, url = {https://doi.org/10.3389/fimmu.2021.690201} } @article{kim2024-38868666, author = {Kim, A. Y. and Al Jerdi, S. and MacDonald, R. and Triggle, C. R.}, title = {{Alzheimer's disease and its treatment-yesterday, today, and tomorrow}}, journal = {Frontiers in pharmacology}, year = {2024}, doi = {10.3389/fphar.2024.1399121}, pmid = {38868666}, url = {https://doi.org/10.3389/fphar.2024.1399121} } @article{wielage2016-27326725, author = {Wielage, Ronald C. and Perk, Sinem and Campbell, Noll L. and Klein, Timothy M. and Posta, Linda M. and Yuran, Thomas E. and Klein, Robert W. and Ng, Daniel}, title = {{Mirabegron for the treatment of overactive bladder: cost-effectiveness from US commercial health-plan and Medicare Advantage perspectives}}, journal = {Journal of Medical Economics}, year = {2016}, doi = {10.1080/13696998.2016.1204307}, pmid = {27326725}, url = {https://doi.org/10.1080/13696998.2016.1204307} } @article{zakarias2016-27567863, author = {Zakarias, Johanne Købstrup and Jensen‐Dahm, Christina and Nørgaard, Ane and Stevnsborg, Lea and Gasse, Christiane and Andersen, Bodil Gramkow and Jakobsen, Søren and Waldorff, Frans Boch and others}, title = {{Geographical Variation in Antipsychotic Drug Use in Elderly Patients with Dementia: A Nationwide Study}}, journal = {Journal of Alzheimer s Disease}, year = {2016}, doi = {10.3233/jad-160485}, pmid = {27567863}, url = {https://doi.org/10.3233/jad-160485} } @article{mu2026-42785333, author = {Mu, Rui and Hofmann, Anna and Gong, Katherine and Liu, Menghan and Roussak, Alex and Lowery, Joseph and Chen, Yike and Paczynski, Madeline and others}, title = {{Dynamic changes in plasma biomarkers of Alzheimer's disease in patients treated with lecanemab: a longitudinal cohort study}}, journal = {The Lancet Neurology}, year = {2026}, doi = {10.1016/s1474-4422(26)00284-x}, pmid = {42785333}, url = {https://doi.org/10.1016/s1474-4422(26)00284-x} } @article{michaelian2025-39912236, author = {Michaelian, Johannes C. and Rowe, Christopher C. and Kurrle, Susan E and Pond, Constance Dimity and Woodward, Michael and Naismith, Sharon Linda}, title = {{Is Australia ready for the rollout of amyloid‐targeting therapies for Alzheimer disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics}}, journal = {Internal Medicine Journal}, year = {2025}, doi = {10.1111/imj.16637}, pmid = {39912236}, url = {https://doi.org/10.1111/imj.16637} } @article{hartz2025-39949872, author = {Hartz, Sarah M. and Schindler, Suzanne Elizabeth and Streitz, Marissa L. and Moulder, Krista L. and Mozersky, Jessica T. and Wang, Guoqiao and Xiong, Chengjie and Morris, John C.}, title = {{Assessing the clinical meaningfulness of slowing CDR‐SB progression with disease‐modifying therapies for Alzheimer's disease}}, journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions}, year = {2025}, doi = {10.1002/trc2.70033}, pmid = {39949872}, url = {https://doi.org/10.1002/trc2.70033} } @article{okonkwo2025-39760440, author = {Okonkwo, Ozioma C. and Mindt, Mónica Rivera and Weiner, Michael Walter and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Alzheimer's Disease Neuroimaging Initiative: Two decades of pioneering Alzheimer's disease research and future directions}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.14186}, pmid = {39760440}, url = {https://doi.org/10.1002/alz.14186} } @article{singh2026-42162487, author = {Singh, Alpana and Denkinger, Marisa N. and Leuzy, Antoine and Dieckhoff, Kari and Liu, Jame and Marques, Tainá M. and Monuki, Edwin S. and Stark, Craig and others}, title = {{A plasma protein signature for cerebral amyloid angiopathy}}, journal = {Acta Neuropathologica}, year = {2026}, doi = {10.1007/s00401-026-03030-5}, pmid = {42162487}, url = {https://doi.org/10.1007/s00401-026-03030-5} } @article{zhao2026-41549124, author = {Zhao, Lijun and Yuan, Jiamin and Yang, Qing and Ma, Jing and Yang, Fenghao and Zou, Yutong and Liu, Ke and Liu, Fang}, title = {{Diabetes and its complications: molecular mechanisms, prevention and treatment}}, journal = {Signal Transduction and Targeted Therapy}, year = {2026}, doi = {10.1038/s41392-025-02401-w}, pmid = {41549124}, url = {https://doi.org/10.1038/s41392-025-02401-w} } @article{hunt2025-40126467, author = {Hunt, Lauren J. and Gan, Siqi and Boscardin, W. John and Harrison, Krista Lyn and Growdon, Matthew E. and Muench, Ulrike and Gerlach, Lauren B. and Smith, Alexander Kingsbury and others}, title = {{Continued Use of Cholinesterase Inhibitors and Memantine in Hospice}}, journal = {JAMA Internal Medicine}, year = {2025}, doi = {10.1001/jamainternmed.2024.8579}, pmid = {40126467}, url = {https://doi.org/10.1001/jamainternmed.2024.8579} } @article{brown2026-42257423, author = {Brown, Robin and Allan, Stuart McRae and Markus, Hugh Stephen}, title = {{The role of inflammation in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications}}, journal = {International Journal of Stroke}, year = {2026}, doi = {10.1177/17474930261461366}, pmid = {42257423}, url = {https://doi.org/10.1177/17474930261461366} } @article{cummings2023-37357276, author = {Cummings, Jeffrey L. and Apostolova, L and Rabinovici, Gil D. and Atri, A and Aisen, Pau and Greenberg, S and Hendrix, S and Selkoe, D and Weiner, M and Petersen, R.C. and Salloway, Stephen}, title = {{Lecanemab: Appropriate Use Recommendations}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2023}, doi = {10.14283/jpad.2023.30}, pmid = {37357276}, url = {https://doi.org/10.14283/jpad.2023.30} } @article{thomassen2026-42736378, author = {Thomassen, J. Q. and Leonard, H. and Ulms, B. and Grenier-Boley, B. and Heikkinen, S. and Garcia-González, P. and Castillo-Morales, A. and Kikuchi, M. and Gim, J. and Cao, H. and Küçükali, F. and Amin, N. and others}, title = {{APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease}}, journal = {Nature genetics}, year = {2026}, doi = {10.1038/s41588-026-02713-9}, pmid = {42736378}, url = {https://doi.org/10.1038/s41588-026-02713-9} } @article{wisch2023-36542469, author = {Wisch, J. K. and Butt, O. H. and Gordon, B. A. and Schindler, S. E. and Fagan, A. M. and Henson, R. L. and Yang, C. and Boerwinkle, A. H. and others}, title = {{Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression}}, journal = {Brain : a journal of neurology}, year = {2023}, doi = {10.1093/brain/awac484}, pmid = {36542469}, url = {https://doi.org/10.1093/brain/awac484} } @article{kim2023-37403351, author = {Kim, A. and Lee, J. and Moon, H. and Kim, C. and Yoo, M. Y. and Park, W. Y. and Kim, W. D. and Seo, Y. S.}, title = {{The effects of low-dose radiation therapy in patients with mild-to-moderate Alzheimer's dementia: an interim analysis of a pilot study}}, journal = {Radiation oncology journal}, year = {2023}, doi = {10.3857/roj.2023.00052}, pmid = {37403351}, url = {https://doi.org/10.3857/roj.2023.00052} } @article{withington2022-35401412, author = {Withington, C. G. and Turner, R. S.}, title = {{Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease}}, journal = {Frontiers in neurology}, year = {2022}, doi = {10.3389/fneur.2022.862369}, pmid = {35401412}, url = {https://doi.org/10.3389/fneur.2022.862369} } @article{khan2020-32484110, author = {Khan, S. and Barve, K. H. and Kumar, M. S.}, title = {{Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease}}, journal = {Current neuropharmacology}, year = {2020}, doi = {10.2174/1570159x18666200528142429}, pmid = {32484110}, url = {https://doi.org/10.2174/1570159x18666200528142429} } @article{piguet2011-21147039, author = {Piguet, O. and Hornberger, M. and Mioshi, E. and Hodges, JR.}, title = {{Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management}}, journal = {The Lancet. Neurology}, year = {2011}, doi = {10.1016/s1474-4422(10)70299-4}, pmid = {21147039}, url = {https://doi.org/10.1016/s1474-4422(10)70299-4} } @article{kales2019-30068400, author = {Kales, H. C. and Lyketsos, C. G. and Miller, E. M. and Ballard, C.}, title = {{Management of behavioral and psychological symptoms in people with Alzheimer's disease: an international Delphi consensus}}, journal = {International psychogeriatrics}, year = {2019}, doi = {10.1017/s1041610218000534}, pmid = {30068400}, url = {https://doi.org/10.1017/s1041610218000534} } @article{sacktor2002-11935465, author = {Sacktor, N. and McDermott, M. P. and Marder, K. and Schifitto, G. and Selnes, O. A. and McArthur, J. C. and Stern, Y. and Albert, S. and others}, title = {{HIV-associated cognitive impairment before and after the advent of combination therapy}}, journal = {Journal of neurovirology}, year = {2002}, doi = {10.1080/13550280290049615}, pmid = {11935465}, url = {https://doi.org/10.1080/13550280290049615} } @article{pirker2017-27770207, author = {Pirker, W. and Katzenschlager, R.}, title = {{Gait disorders in adults and the elderly : A clinical guide}}, journal = {Wiener klinische Wochenschrift}, year = {2017}, doi = {10.1007/s00508-016-1096-4}, pmid = {27770207}, url = {https://doi.org/10.1007/s00508-016-1096-4} } @article{tanaka2004-14627698, author = {Tanaka, M. and Kim, Y. M. and Lee, G. and Junn, E. and Iwatsubo, T. and Mouradian, M. M.}, title = {{Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective}}, journal = {The Journal of biological chemistry}, year = {2004}, doi = {10.1074/jbc.m310994200}, pmid = {14627698}, url = {https://doi.org/10.1074/jbc.m310994200} } @article{cheng2024-38382465, author = {Cheng, F. and Wang, F. and Tang, J. and Zhou, Y. and Fu, Z. and Zhang, P. and Haines, J. L. and Leverenz, J. B. and others}, title = {{Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease}}, journal = {Cell reports. Medicine}, year = {2024}, doi = {10.1016/j.xcrm.2023.101379}, pmid = {38382465}, url = {https://doi.org/10.1016/j.xcrm.2023.101379} } @article{delamonte2012-22329651, author = {de la Monte, S. M.}, title = {{Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease}}, journal = {Current Alzheimer research}, year = {2012}, doi = {10.2174/156720512799015037}, pmid = {22329651}, url = {https://doi.org/10.2174/156720512799015037} } @article{neth2017-29163128, author = {Neth, B. J. and Craft, S.}, title = {{Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00345}, pmid = {29163128}, url = {https://doi.org/10.3389/fnagi.2017.00345} } @article{dilazzaro2021-34482205, author = {Di Lazzaro, V. and Bella, R. and Benussi, A. and Bologna, M. and Borroni, B. and Capone, F. and Chen, K. S. and Chen, R. and others}, title = {{Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia}}, journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology}, year = {2021}, doi = {10.1016/j.clinph.2021.05.035}, pmid = {34482205}, url = {https://doi.org/10.1016/j.clinph.2021.05.035} } @article{demuynck2024-37535809, author = {De Muynck, K. and Heyerick, L. and De Ponti, F. F. and Vanderborght, B. and Meese, T. and Van Campenhout, S. and Baudonck, L. and Gijbels, E. and others}, title = {{Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis}}, journal = {Hepatology (Baltimore, Md.)}, year = {2024}, doi = {10.1097/hep.0000000000000557}, pmid = {37535809}, url = {https://doi.org/10.1097/hep.0000000000000557} } @article{lopez2002-11861686, author = {Lopez, O. L. and Becker, J. T. and Wisniewski, S. and Saxton, J. and Kaufer, D. I. and DeKosky, S. T.}, title = {{Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2002}, doi = {10.1136/jnnp.72.3.310}, pmid = {11861686}, url = {https://doi.org/10.1136/jnnp.72.3.310} } @article{scotter2015-25652699, author = {Scotter, E. L. and Chen, H. J. and Shaw, C. E.}, title = {{TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets}}, journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics}, year = {2015}, doi = {10.1007/s13311-015-0338-x}, pmid = {25652699}, url = {https://doi.org/10.1007/s13311-015-0338-x} } @article{hung2017-28720101, author = {Hung, S. Y. and Fu, W. M.}, title = {{Drug candidates in clinical trials for Alzheimer's disease}}, journal = {Journal of biomedical science}, year = {2017}, doi = {10.1186/s12929-017-0355-7}, pmid = {28720101}, url = {https://doi.org/10.1186/s12929-017-0355-7} } @article{ettner2010-20217267, author = {Ettner, Susan L. and Steers, Neil and Duru, Obidiugwu Kenrik and Turk, Norman and Quiter, Elaine S. and Schmittdiel, Julie A. and Mangione, Carol M.}, title = {{Entering and Exiting the Medicare Part D Coverage Gap: Role of Comorbidities and Demographics}}, journal = {Journal of General Internal Medicine}, year = {2010}, doi = {10.1007/s11606-010-1300-6}, pmid = {20217267}, url = {https://doi.org/10.1007/s11606-010-1300-6} } @article{abler2020-6d3f04fc, author = {Abler, Victor and Rashid, Nazia and Skoog, Ben and Halpern, Rachel and Bunner, Scott H. and Frazer, Monica}, title = {{A patient journey analysis: Identification and treatment of dementia with Lewy bodies}}, journal = {Alzheimer s \& Dementia}, year = {2020}, doi = {10.1002/alz.047079}, url = {https://doi.org/10.1002/alz.047079} } @article{zhou2025-40372759, author = {Zhou, Frank F. and Essien, Utibe R. and Souza, Jeffrey M. and Sarkisian, Catherine A. and Damberg, Cheryl L. and Landon, Bruce E. and Mafi, John N.}, title = {{Disparities in Early Lecanemab Uptake Among US Medicare Beneficiaries}}, journal = {JAMA Network Open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.11711}, pmid = {40372759}, url = {https://doi.org/10.1001/jamanetworkopen.2025.11711} } @article{uehara2025-41303831, author = {Uehara, Maria Anabel and Kalia, Sumeet and Campuzano, Mari T. Garcia and Moussavi, Zahra}, title = {{ADAS-Cog Trajectories Differ from Expected Decline in Dementia Following Repeated Non-Invasive Interventions over 3 Years}}, journal = {Medicina}, year = {2025}, doi = {10.3390/medicina61111994}, pmid = {41303831}, url = {https://doi.org/10.3390/medicina61111994} } @article{torresyaghi2025-41286676, author = {Torres-Yaghi, Y. and Chrones, L. and Abler, V. and Brunson, G.}, title = {{Safety and efficacy of pimavanserin in patients with Lewy body dementia experiencing dementia-related psychosis in the HARMONY study}}, journal = {BMC Neurology}, year = {2025}, doi = {10.1186/s12883-025-04496-8}, pmid = {41286676}, url = {https://doi.org/10.1186/s12883-025-04496-8} } @article{yiannopoulou2019-31835422, author = {Yiannopoulou, K. G. and Anastasiou, A. I. and Zachariou, V. and Pelidou, S. H.}, title = {{Reasons for Failed Trials of Disease-Modifying Treatments for Alzheimer Disease and Their Contribution in Recent Research}}, journal = {Biomedicines}, year = {2019}, doi = {10.3390/biomedicines7040097}, pmid = {31835422}, url = {https://doi.org/10.3390/biomedicines7040097} } @article{eratne2022-35179048, author = {Eratne, D. and Janelidze, S. and Malpas, C. B. and Loi, S. and Walterfang, M. and Merritt, A. and Diouf, I. and Blennow, K. and others}, title = {{Plasma neurofilament light chain protein is not increased in treatment-resistant schizophrenia and first-degree relatives}}, journal = {The Australian and New Zealand journal of psychiatry}, year = {2022}, doi = {10.1177/00048674211058684}, pmid = {35179048}, url = {https://doi.org/10.1177/00048674211058684} } @article{duong2021-33841127, author = {Duong, M. T. and Nasrallah, I. M. and Wolk, D. A. and Chang, C. C. Y. and Chang, T. Y.}, title = {{Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy}}, journal = {Frontiers in aging neuroscience}, year = {2021}, doi = {10.3389/fnagi.2021.647990}, pmid = {33841127}, url = {https://doi.org/10.3389/fnagi.2021.647990} } @article{kurellatamura2011-20861818, author = {Kurella Tamura, M. and Yaffe, K.}, title = {{Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies}}, journal = {Kidney international}, year = {2011}, doi = {10.1038/ki.2010.336}, pmid = {20861818}, url = {https://doi.org/10.1038/ki.2010.336} } @article{maron2009-18729731, author = {Maron, B. A. and Loscalzo, J.}, title = {{The treatment of hyperhomocysteinemia}}, journal = {Annual review of medicine}, year = {2009}, doi = {10.1146/annurev.med.60.041807.123308}, pmid = {18729731}, url = {https://doi.org/10.1146/annurev.med.60.041807.123308} } @article{brendza2005-15668737, author = {Brendza, R. P. and Bacskai, B. J. and Cirrito, JR. and Simmons, K. A. and Skoch, J. M. and Klunk, W. E. and Mathis, C. A. and Bales, K. R. and others}, title = {{Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice}}, journal = {The Journal of clinical investigation}, year = {2005}, doi = {10.1172/jci23269}, pmid = {15668737}, url = {https://doi.org/10.1172/jci23269} } @article{bonda2011-21349442, author = {Bonda, D. J. and Lee, H. G. and Camins, A. and Pallàs, M. and Casadesus, G. and Smith, M. A. and Zhu, X.}, title = {{The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations}}, journal = {The Lancet. Neurology}, year = {2011}, doi = {10.1016/s1474-4422(11)70013-8}, pmid = {21349442}, url = {https://doi.org/10.1016/s1474-4422(11)70013-8} } @article{krikorian2010-20047325, author = {Krikorian, R. and Shidler, M. D. and Nash, T. A. and Kalt, W. and Vinqvist-Tymchuk, M. R. and Shukitt-Hale, B. and Joseph, J. A.}, title = {{Blueberry supplementation improves memory in older adults}}, journal = {Journal of agricultural and food chemistry}, year = {2010}, doi = {10.1021/jf9029332}, pmid = {20047325}, url = {https://doi.org/10.1021/jf9029332} } @article{lee2006-17015225, author = {Lee, V. M. and Trojanowski, J. Q.}, title = {{Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery}}, journal = {Neuron}, year = {2006}, doi = {10.1016/j.neuron.2006.09.026}, pmid = {17015225}, url = {https://doi.org/10.1016/j.neuron.2006.09.026} } @article{bondarev2021-33971031, author = {Bondarev, A. D. and Attwood, M. M. and Jonsson, J. and Chubarev, V. N. and Tarasov, V. V. and Schiöth, H. B.}, title = {{Recent developments of HDAC inhibitors: Emerging indications and novel molecules}}, journal = {British journal of clinical pharmacology}, year = {2021}, doi = {10.1111/bcp.14889}, pmid = {33971031}, url = {https://doi.org/10.1111/bcp.14889} } @article{nakamura2012-22464332, author = {Nakamura, K. and Greenwood, A. and Binder, L. and Bigio, E. H. and Denial, S. and Nicholson, L. and Zhou, X. Z. and Lu, K. P.}, title = {{Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease}}, journal = {Cell}, year = {2012}, doi = {10.1016/j.cell.2012.02.016}, pmid = {22464332}, url = {https://doi.org/10.1016/j.cell.2012.02.016} } @article{lukiw2005-16151530, author = {Lukiw, W. J. and Cui, J. G. and Marcheselli, V. L. and Bodker, M. and Botkjaer, A. and Gotlinger, K. and Serhan, C. N. and Bazan, N. G.}, title = {{A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease}}, journal = {The Journal of clinical investigation}, year = {2005}, doi = {10.1172/jci25420}, pmid = {16151530}, url = {https://doi.org/10.1172/jci25420} } @article{wang2022-36031601, author = {Wang, Y. and Johnson, K. C. C. and Gatti-Mays, M. E. and Li, Z.}, title = {{Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy}}, journal = {Journal of hematology \& oncology}, year = {2022}, doi = {10.1186/s13045-022-01335-y}, pmid = {36031601}, url = {https://doi.org/10.1186/s13045-022-01335-y} } @article{mehta2017-28460541, author = {Mehta, D. and Jackson, R. and Paul, G. and Shi, J. and Sabbagh, M.}, title = {{Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015}}, journal = {Expert opinion on investigational drugs}, year = {2017}, doi = {10.1080/13543784.2017.1323868}, pmid = {28460541}, url = {https://doi.org/10.1080/13543784.2017.1323868} } @article{rataj2024-38833712, author = {Rataj, Alison C. and Alcusky, Matthew James and Baek, Jonggyu and Ott, Brian R. and Lapane, Kate L.}, title = {{Geographic Variation of Antidementia and Antipsychotic Medication Use Among US Nursing Home Residents With Dementia}}, journal = {Medical Care}, year = {2024}, doi = {10.1097/mlr.0000000000002016}, pmid = {38833712}, url = {https://doi.org/10.1097/mlr.0000000000002016} } @article{zhou2025-41447712, author = {Zhou, Jin and Andreozzi, Erica M. and Llibre‐Guerra, Jorge J. and Clifford, David B. and Li, David and Wang, Guoqiao and Schneider, Lon S. S. and McDade, Eric and others}, title = {{Safety of Lecanemab After 6‐Month Treatment in the DIAN‐TU‐001 Trial}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70859_105304}, pmid = {41447712}, url = {https://doi.org/10.1002/alz70859_105304} } @article{hawley2025-39978410, author = {Hawley, John A. and Forster, Samuel C. and Giles, Edward M.}, title = {{Exercise, the Gut Microbiome and Gastrointestinal Diseases: Therapeutic Impact and Molecular Mechanisms}}, journal = {Gastroenterology}, year = {2025}, doi = {10.1053/j.gastro.2025.01.224}, pmid = {39978410}, url = {https://doi.org/10.1053/j.gastro.2025.01.224} } @article{ahmed2025-9ee4e49b, author = {Ahmed, Maryam Mohammed Ali and Kowayer, Jamila Saeed Ahmad Bin and Lootah, Amna and Alhammdi, Sara Ibrahim and Alshamsi, Fatima Ahmed Sultan and Almheiri, Maha and Ali, Reem Ibrahim and Alhosani, Abeer and others}, title = {{The Effect of Hypertension on Cognitive Decline and Dementia: A Meta- Analysis}}, journal = {Cardiology and Cardiovascular Medicine}, year = {2025}, doi = {10.26502/fccm.92920425}, url = {https://doi.org/10.26502/fccm.92920425} } @article{kersten2026-41553533, author = {Kersten, Hege and Barca, Maria Lage and Eldholm, Rannveig Sakshaug and Persson, Karin and Thomasgaard, Lara and Jaioun, Keson and Saltvedt, Ingvild Tina and Selbæk, Geir and others}, title = {{Potentially inappropriate medications related to two-year progression of mild cognitive impairment and dementia}}, journal = {European Journal of Clinical Pharmacology}, year = {2026}, doi = {10.1007/s00228-025-03977-6}, pmid = {41553533}, url = {https://doi.org/10.1007/s00228-025-03977-6} } @article{liu2025-41568736, author = {Liu, Wenying and Li, Yan and Qin, Wei and Wang, Xuechu and Li, Wenwen and Li, Ying and {Alzheimer's Disease Neuroimaging Initiative} and Jia, Jianping}, title = {{The impact of cholinesterase inhibitors on cognitive trajectories in mild cognitive impairment patients based on amyloid beta status}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70193}, pmid = {41568736}, url = {https://doi.org/10.1002/alz.70193} } @article{mur2025-41128551, author = {Mur, Jure and Stirland, Lucy and Terrera, Graciela Muniz and Leist, Anja K.}, title = {{A simulation study comparing anticholinergic drug use with polypharmacy for risk of death, dementia, and delirium in UK Biobank}}, journal = {The Journals of Gerontology Series A}, year = {2025}, doi = {10.1093/gerona/glaf232}, pmid = {41128551}, url = {https://doi.org/10.1093/gerona/glaf232} } @article{noh2025-40640892, author = {Noh, Min‐Young and Kwon, Hyuk Sung and Kwon, Min‐Soo and Nahm, Minyeop and Jin, Hee Kyung and Bae, Jae‐sung and Kim, Seung Hyun}, title = {{Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions}}, journal = {Molecular Neurodegeneration}, year = {2025}, doi = {10.1186/s13024-025-00867-4}, pmid = {40640892}, url = {https://doi.org/10.1186/s13024-025-00867-4} } @article{delima2025-39997749, author = {de Lima, Enzo Pereira and Laurindo, Lucas Fornari and Catharin, Vitor Cavallari Strozze and Direito, Rosa and Tanaka, Masaru and German, Íris Jasmin Santos and Lamas, Caroline Barbalho and Guiguer, Élen Landgraf and others}, title = {{Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence}}, journal = {Metabolites}, year = {2025}, doi = {10.3390/metabo15020124}, pmid = {39997749}, url = {https://doi.org/10.3390/metabo15020124} } @article{wu2025-40442885, author = {Wu, Chuang‐Kuo and Fuh, Jong‐Ling}, title = {{A 2025 update on treatment strategies for the Alzheimer’s disease spectrum}}, journal = {Journal of the Chinese Medical Association}, year = {2025}, doi = {10.1097/jcma.0000000000001252}, pmid = {40442885}, url = {https://doi.org/10.1097/jcma.0000000000001252} } @article{fujiwara2025-40961130, author = {Fujiwara, Takeshi and Koshiaris, Constantinos and Cai, Ting and Wang, Ariel and Lee, Joseph Jonathan and Lay-Flurrie, Sarah L and Banerjee, Amitava and Clegg, Andrew Paul and others}, title = {{Associations between falls and other serious adverse events and antihypertensive medication in individuals with dementia: An observational cohort study}}, journal = {PLoS Medicine}, year = {2025}, doi = {10.1371/journal.pmed.1004731}, pmid = {40961130}, url = {https://doi.org/10.1371/journal.pmed.1004731} } @article{zhang2025-39878947, author = {Zhang, Yuchen and Sereika, Susan M. and Seaman, Jennifer Burgher and Pettigrew, Corinne A. and Albert, Marilyn and Lingler, Jennifer Hagerty}, title = {{Caregivers’ Perspectives on Discussions of Medical Treatment Preferences for People Living With Dementia Are Associated With Their Dementia Health Literacy and the Caregiving Relationship}}, journal = {The Gerontologist}, year = {2025}, doi = {10.1093/geront/gnaf033}, pmid = {39878947}, url = {https://doi.org/10.1093/geront/gnaf033} } @article{xia2025-40730714, author = {Xia, X. and Aye, S. and Frisell, O. and Aho, E. and Handels, R. and Li, Y. and Wimo, A. and Winblad, B. and Eriksdotter, M. and Skillbäck, T. B. and Kern, S. and Zetterberg, H. and others}, title = {{The Cost-Effective Price of Lecanemab for Patients with Early Alzheimer's Disease in Sweden}}, journal = {PharmacoEconomics}, year = {2025}, doi = {10.1007/s40273-025-01527-7}, pmid = {40730714}, url = {https://doi.org/10.1007/s40273-025-01527-7} } @article{chen2011-21118811, author = {Chen, H. K. and Ji, Z. S. and Dodson, S. E. and Miranda, R. D. and Rosenblum, C. I. and Reynolds, I. J. and Freedman, S. B. and Weisgraber, K. H. and others}, title = {{Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease}}, journal = {The Journal of biological chemistry}, year = {2011}, doi = {10.1074/jbc.m110.151084}, pmid = {21118811}, url = {https://doi.org/10.1074/jbc.m110.151084} } @article{soto2015-25226218, author = {Soto, M. and Andrieu, S. and Nourhashemi, F. and Ousset, P. J. and Ballard, C. and Robert, P. and Vellas, B. and Lyketsos, C. G. and others}, title = {{Medication development for agitation and aggression in Alzheimer disease: review and discussion of recent randomized clinical trial design}}, journal = {International psychogeriatrics}, year = {2015}, doi = {10.1017/s1041610214001720}, pmid = {25226218}, url = {https://doi.org/10.1017/s1041610214001720} } @article{maki2013-23715379, author = {Maki, P. M.}, title = {{Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies}}, journal = {Menopause (New York, N.Y.)}, year = {2013}, doi = {10.1097/gme.0b013e3182960cf8}, pmid = {23715379}, url = {https://doi.org/10.1097/gme.0b013e3182960cf8} } @article{mart2021-32746469, author = {Mart, M. F. and Williams Roberson, S. and Salas, B. and Pandharipande, P. P. and Ely, E. W.}, title = {{Prevention and Management of Delirium in the Intensive Care Unit}}, journal = {Seminars in respiratory and critical care medicine}, year = {2021}, doi = {10.1055/s-0040-1710572}, pmid = {32746469}, url = {https://doi.org/10.1055/s-0040-1710572} } @article{huckans2013-23471631, author = {Huckans, M. and Hutson, L. and Twamley, E. and Jak, A. and Kaye, J. and Storzbach, D.}, title = {{Efficacy of cognitive rehabilitation therapies for mild cognitive impairment (MCI) in older adults: working toward a theoretical model and evidence-based interventions}}, journal = {Neuropsychology review}, year = {2013}, doi = {10.1007/s11065-013-9230-9}, pmid = {23471631}, url = {https://doi.org/10.1007/s11065-013-9230-9} } @article{hugo2014-25037289, author = {Hugo, J. and Ganguli, M.}, title = {{Dementia and cognitive impairment: epidemiology, diagnosis, and treatment}}, journal = {Clinics in geriatric medicine}, year = {2014}, doi = {10.1016/j.cger.2014.04.001}, pmid = {25037289}, url = {https://doi.org/10.1016/j.cger.2014.04.001} } @article{morales2014-24795567, author = {Morales, I. and Guzmán-Martínez, L. and Cerda-Troncoso, C. and Farías, G. A. and Maccioni, R. B.}, title = {{Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches}}, journal = {Frontiers in cellular neuroscience}, year = {2014}, doi = {10.3389/fncel.2014.00112}, pmid = {24795567}, url = {https://doi.org/10.3389/fncel.2014.00112} } @article{wang2012-22932872, author = {Wang, I. F. and Guo, B. S. and Liu, Y. C. and Wu, C. C. and Yang, C. H. and Tsai, K. J. and Shen, C. K.}, title = {{Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2012}, doi = {10.1073/pnas.1206362109}, pmid = {22932872}, url = {https://doi.org/10.1073/pnas.1206362109} } @article{wong2004-14709552, author = {Wong, G. T. and Manfra, D. and Poulet, F. M. and Zhang, Q. and Josien, H. and Bara, T. and Engstrom, L. and Pinzon-Ortiz, M. and others}, title = {{Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation}}, journal = {The Journal of biological chemistry}, year = {2004}, doi = {10.1074/jbc.m311652200}, pmid = {14709552}, url = {https://doi.org/10.1074/jbc.m311652200} } @article{gong2004-15578094, author = {Gong, B. and Vitolo, O. V. and Trinchese, F. and Liu, S. and Shelanski, M. and Arancio, O.}, title = {{Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment}}, journal = {The Journal of clinical investigation}, year = {2004}, doi = {10.1172/jci22831}, pmid = {15578094}, url = {https://doi.org/10.1172/jci22831} } @article{hemming2007-17760499, author = {Hemming, M. L. and Patterson, M. and Reske-Nielsen, C. and Lin, L. and Isacson, O. and Selkoe, D. J.}, title = {{Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease}}, journal = {PLoS medicine}, year = {2007}, doi = {10.1371/journal.pmed.0040262}, pmid = {17760499}, url = {https://doi.org/10.1371/journal.pmed.0040262} } @article{sveikata2022-34905943, author = {Sveikata, L. and Charidimou, A. and Viswanathan, A.}, title = {{Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab}}, journal = {Stroke}, year = {2022}, doi = {10.1161/strokeaha.121.036873}, pmid = {34905943}, url = {https://doi.org/10.1161/strokeaha.121.036873} } @article{alvarado2024-38181731, author = {Alvarado, C. X. and Makarious, M. B. and Weller, C. A. and Vitale, D. and Koretsky, M. J. and Bandres-Ciga, S. and Iwaki, H. and Levine, K. and others}, title = {{omicSynth: An open multi-omic community resource for identifying druggable targets across neurodegenerative diseases}}, journal = {American journal of human genetics}, year = {2024}, doi = {10.1016/j.ajhg.2023.12.006}, pmid = {38181731}, url = {https://doi.org/10.1016/j.ajhg.2023.12.006} } @article{maczurek2008-18655815, author = {Maczurek, A. and Hager, K. and Kenklies, M. and Sharman, M. and Martins, R. and Engel, J. and Carlson, D. A. and Münch, G.}, title = {{Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease}}, journal = {Advanced drug delivery reviews}, year = {2008}, doi = {10.1016/j.addr.2008.04.015}, pmid = {18655815}, url = {https://doi.org/10.1016/j.addr.2008.04.015} } @article{jantzen2002-11896164, author = {Jantzen, P. T. and Connor, K. E. and DiCarlo, G. and Wenk, G. L. and Wallace, J. L. and Rojiani, A. M. and Coppola, D. and Morgan, D. and others}, title = {{Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2002}, doi = {10.1523/jneurosci.22-06-02246.2002}, pmid = {11896164}, url = {https://doi.org/10.1523/jneurosci.22-06-02246.2002} } @article{mandler2014-24525765, author = {Mandler, M. and Valera, E. and Rockenstein, E. and Weninger, H. and Patrick, C. and Adame, A. and Santic, R. and Meindl, S. and others}, title = {{Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials}}, journal = {Acta neuropathologica}, year = {2014}, doi = {10.1007/s00401-014-1256-4}, pmid = {24525765}, url = {https://doi.org/10.1007/s00401-014-1256-4} } @article{ballard2020-32939050, author = {Ballard, C. and Aarsland, D. and Cummings, J. and O'Brien, J. and Mills, R. and Molinuevo, J. L. and Fladby, T. and Williams, G. and others}, title = {{Drug repositioning and repurposing for Alzheimer disease}}, journal = {Nature reviews. Neurology}, year = {2020}, doi = {10.1038/s41582-020-0397-4}, pmid = {32939050}, url = {https://doi.org/10.1038/s41582-020-0397-4} } @article{hillerstrom2024-38480678, author = {Hillerstrom, Hampus and Fisher, Richard Alan and Janicki, Matthew P. and Chicoine, Brian Allen and Christian, Bradley T. and Esbensen, Anna J. and Esralew, Lucille and Fortea, Juan and others}, title = {{Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome}}, journal = {Alzheimer s \& Dementia}, year = {2024}, doi = {10.1002/alz.13778}, pmid = {38480678}, url = {https://doi.org/10.1002/alz.13778} } @article{wildsmith2025-41447716, author = {Wildsmith, Kristin R. and Charil, Arnaud and Benzinger, Tammie L.S. and Gordon, Brian Andrew and Bhagunde, Pratik R. and Li, David and Wang, Guoqiao and Reyderman, Larisa and others}, title = {{Lecanemab in DIAD: 6‐Month Amyloid PET Results from the DIAN‐TU‐001 Trial}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz70859_105303}, pmid = {41447716}, url = {https://doi.org/10.1002/alz70859_105303} } @article{chen2025-40459787, author = {Chen, Charles D. and Franklin, Erin E. and Li, Yan and Joseph‐Mathurin, Nelly and Burns, Aime and Hobbs, Diana A. and McCullough, Austin A. and Schultz, Stephanie A. and others}, title = {{Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease}}, journal = {Acta Neuropathologica}, year = {2025}, doi = {10.1007/s00401-025-02890-7}, pmid = {40459787}, url = {https://doi.org/10.1007/s00401-025-02890-7} } @article{sannidhi2025-40733007, author = {Sannidhi, Deepa and Abeles, Ruth and Andrew, William and Bonnet, Jonathan P. and Vitale, Kenneth and Niranjan, Varalakshmi and Gulati, Mahima and Pauly, Kaitlyn R. and others}, title = {{Lifestyle Medicine for Obesity in the Era of Highly Effective Anti-Obesity Treatment}}, journal = {Nutrients}, year = {2025}, doi = {10.3390/nu17142382}, pmid = {40733007}, url = {https://doi.org/10.3390/nu17142382} } @article{byeon2025-39944528, author = {Byeon, Gihwan and Kang, Dong Woo and Kim, Yeshin and Kim, Geon Ha and Kim, Ko Woon and Kim, Hee-jin and Na, Seunghee and Park, Kee Hyung and others}, title = {{Clinical Practice Guidelines for Dementia: Recommendations for the Pharmacological Treatment of Behavioral and Psychological Symptoms}}, journal = {Dementia and Neurocognitive Disorders}, year = {2025}, doi = {10.12779/dnd.2025.24.1.24}, pmid = {39944528}, url = {https://doi.org/10.12779/dnd.2025.24.1.24} } @article{lennon2026-41554956, author = {Lennon, Matthew J. and Sachdev, Perminder Singh}, title = {{Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future}}, journal = {Neuropsychopharmacology}, year = {2026}, doi = {10.1038/s41386-026-02331-3}, pmid = {41554956}, url = {https://doi.org/10.1038/s41386-026-02331-3} } @article{mao2026-41520099, author = {Mao, Chenhui and Wang, Wenjun and Huang, Xinying and Wu, Meiqi and Wang, Yifei and Wang, Tianyi and Qiu, Yuyue and Chu, Shanshan and others}, title = {{Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution}}, journal = {Alzheimer s Research \& Therapy}, year = {2026}, doi = {10.1186/s13195-025-01943-z}, pmid = {41520099}, url = {https://doi.org/10.1186/s13195-025-01943-z} } @article{zimmer2025-41330788, author = {Zimmer, Jennifer A. and Sims, John R. and Evans, Cynthia Duggan and Nery, Emel Serap Monkul and Wang, Hong and Wessels, Alette M. and Tronchin, Giulia and Sato, Shoichiro and others}, title = {{Donanemab in early symptomatic Alzheimer’s disease: results from the TRAILBLAZER-ALZ 2 long-term extension}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100446}, pmid = {41330788}, url = {https://doi.org/10.1016/j.tjpad.2025.100446} } @article{bush2026-42366006, author = {Bush, Shirley Harvey and Kabir, Monisha and French-Merkley, Véronique and Sikora, Lindsey and Agar, Meera Ruth and Hosie, Annmarie and Featherstone, Imogen and Isenberg, Sarina R. and others}, title = {{Clinical checklists of multicomponent non-pharmacological interventions for delirium management in adult patients in non-ICU inpatient healthcare settings: a rapid review}}, journal = {BMJ Open}, year = {2026}, doi = {10.1136/bmjopen-2025-105740}, pmid = {42366006}, url = {https://doi.org/10.1136/bmjopen-2025-105740} } @article{knopman2023-36948153, author = {Knopman, D. S.}, title = {{Lecanemab reduces brain amyloid-β and delays cognitive worsening}}, journal = {Cell reports. Medicine}, year = {2023}, doi = {10.1016/j.xcrm.2023.100982}, pmid = {36948153}, url = {https://doi.org/10.1016/j.xcrm.2023.100982} } @article{loeravalencia2019-30878503, author = {Loera-Valencia, R. and Goikolea, J. and Parrado-Fernandez, C. and Merino-Serrais, P. and Maioli, S.}, title = {{Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment}}, journal = {The Journal of steroid biochemistry and molecular biology}, year = {2019}, doi = {10.1016/j.jsbmb.2019.03.003}, pmid = {30878503}, url = {https://doi.org/10.1016/j.jsbmb.2019.03.003} } @article{rao2009-18782632, author = {Rao, S. C. and Dove, G. and Cascino, G. D. and Petersen, R. C.}, title = {{Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome}}, journal = {Epilepsy \& behavior : E\&B}, year = {2009}, doi = {10.1016/j.yebeh.2008.08.012}, pmid = {18782632}, url = {https://doi.org/10.1016/j.yebeh.2008.08.012} } @article{agarwal2023-37651273, author = {Agarwal, A. and Gupta, V. and Brahmbhatt, P. and Desai, A. and Vibhute, P. and Joseph-Mathurin, N. and Bathla, G.}, title = {{Amyloid-related Imaging Abnormalities in Alzheimer Disease Treated with Anti-Amyloid-β Therapy}}, journal = {Radiographics : a review publication of the Radiological Society of North America, Inc}, year = {2023}, doi = {10.1148/rg.230009}, pmid = {37651273}, url = {https://doi.org/10.1148/rg.230009} } @article{mandelblatt2014-24841981, author = {Mandelblatt, J. S. and Stern, R. A. and Luta, G. and McGuckin, M. and Clapp, J. D. and Hurria, A. and Jacobsen, P. B. and others}, title = {{Cognitive impairment in older patients with breast cancer before systemic therapy: is there an interaction between cancer and comorbidity?}}, journal = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year = {2014}, doi = {10.1200/jco.2013.54.2050}, pmid = {24841981}, url = {https://doi.org/10.1200/jco.2013.54.2050} } @article{salzman2008-18494535, author = {Salzman, C. and Jeste, D. V. and Meyer, R. E. and Cohen-Mansfield, J. and Cummings, J. and Grossberg, G. T. and Jarvik, L. and Kraemer, H. C. and others}, title = {{Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy}}, journal = {The Journal of clinical psychiatry}, year = {2008}, doi = {10.4088/jcp.v69n0602}, pmid = {18494535}, url = {https://doi.org/10.4088/jcp.v69n0602} } @article{qiu2024-38335558, author = {Qiu, Y. and Cheng, F.}, title = {{Artificial intelligence for drug discovery and development in Alzheimer's disease}}, journal = {Current opinion in structural biology}, year = {2024}, doi = {10.1016/j.sbi.2024.102776}, pmid = {38335558}, url = {https://doi.org/10.1016/j.sbi.2024.102776} } @article{farkas2007-17296232, author = {Farkas, E. and Luiten, P. G. and Bari, F.}, title = {{Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases}}, journal = {Brain research reviews}, year = {2007}, doi = {10.1016/j.brainresrev.2007.01.003}, pmid = {17296232}, url = {https://doi.org/10.1016/j.brainresrev.2007.01.003} } @article{pocernich2012-22015471, author = {Pocernich, C. B. and Butterfield, D. A.}, title = {{Elevation of glutathione as a therapeutic strategy in Alzheimer disease}}, journal = {Biochimica et biophysica acta}, year = {2012}, doi = {10.1016/j.bbadis.2011.10.003}, pmid = {22015471}, url = {https://doi.org/10.1016/j.bbadis.2011.10.003} } @article{plascenciavilla2021-32486897, author = {Plascencia-Villa, G. and Perry, G.}, title = {{Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis}}, journal = {Antioxidants \& redox signaling}, year = {2021}, doi = {10.1089/ars.2020.8134}, pmid = {32486897}, url = {https://doi.org/10.1089/ars.2020.8134} } @article{bush1990-2118534, author = {Bush, A. I. and Martins, R. N. and Rumble, B. and Moir, R. and Fuller, S. and Milward, E. and Currie, J. and Ames, D. and others}, title = {{The amyloid precursor protein of Alzheimer's disease is released by human platelets}}, journal = {The Journal of biological chemistry}, year = {1990}, doi = {10.1016/s0021-9258(18)55493-4}, pmid = {2118534}, url = {https://doi.org/10.1016/s0021-9258(18)55493-4} } @article{vingtdeux2007-17468104, author = {Vingtdeux, V. and Hamdane, M. and Loyens, A. and Gelé, P. and Drobeck, H. and Bégard, S. and Galas, M. C. and Delacourte, A. and others}, title = {{Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies}}, journal = {The Journal of biological chemistry}, year = {2007}, doi = {10.1074/jbc.m609475200}, pmid = {17468104}, url = {https://doi.org/10.1074/jbc.m609475200} } @article{ostrowski2007-17646164, author = {Ostrowski, S. M. and Wilkinson, B. L. and Golde, T. E. and Landreth, G.}, title = {{Statins reduce amyloid-beta production through inhibition of protein isoprenylation}}, journal = {The Journal of biological chemistry}, year = {2007}, doi = {10.1074/jbc.m702640200}, pmid = {17646164}, url = {https://doi.org/10.1074/jbc.m702640200} } @article{pedrini2005-15647781, author = {Pedrini, S. and Carter, T. L. and Prendergast, G. and Petanceska, S. and Ehrlich, M. E. and Gandy, S.}, title = {{Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK}}, journal = {PLoS medicine}, year = {2005}, doi = {10.1371/journal.pmed.0020018}, pmid = {15647781}, url = {https://doi.org/10.1371/journal.pmed.0020018} } @article{nizami2019-30740661, author = {Nizami, S. and Hall-Roberts, H. and Warrier, S. and Cowley, S. A. and Di Daniel, E.}, title = {{Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets}}, journal = {British journal of pharmacology}, year = {2019}, doi = {10.1111/bph.14618}, pmid = {30740661}, url = {https://doi.org/10.1111/bph.14618} } @article{fassler2021-33422057, author = {Fassler, M. and Rappaport, M. S. and Cuño, C. B. and George, J.}, title = {{Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models}}, journal = {Journal of neuroinflammation}, year = {2021}, doi = {10.1186/s12974-020-01980-5}, pmid = {33422057}, url = {https://doi.org/10.1186/s12974-020-01980-5} } @article{lu2022-36411661, author = {Lu, Y. P. and Wu, H. W. and Zhu, T. and Li, X. T. and Zuo, J. and Hasan, A. A. and Reichetzeder, C. and Delic, D. and others}, title = {{Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy}}, journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie}, year = {2022}, doi = {10.1016/j.biopha.2022.113947}, pmid = {36411661}, url = {https://doi.org/10.1016/j.biopha.2022.113947} } @article{blennow2012-22951438, author = {Blennow, K. and Zetterberg, H. and Fagan, A. M.}, title = {{Fluid biomarkers in Alzheimer disease}}, journal = {Cold Spring Harbor perspectives in medicine}, year = {2012}, doi = {10.1101/cshperspect.a006221}, pmid = {22951438}, url = {https://doi.org/10.1101/cshperspect.a006221} } @article{vitek2023-36749830, author = {Vitek, G. E. and Decourt, B. and Sabbagh, M. N.}, title = {{Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease}}, journal = {Expert opinion on investigational drugs}, year = {2023}, doi = {10.1080/13543784.2023.2178414}, pmid = {36749830}, url = {https://doi.org/10.1080/13543784.2023.2178414} } @article{holscher2024-38677445, author = {Hölscher, C.}, title = {{Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?}}, journal = {Neuropharmacology}, year = {2024}, doi = {10.1016/j.neuropharm.2024.109952}, pmid = {38677445}, url = {https://doi.org/10.1016/j.neuropharm.2024.109952} } @article{dumont2011-21130159, author = {Dumont, M. and Beal, M. F.}, title = {{Neuroprotective strategies involving ROS in Alzheimer disease}}, journal = {Free radical biology \& medicine}, year = {2011}, doi = {10.1016/j.freeradbiomed.2010.11.026}, pmid = {21130159}, url = {https://doi.org/10.1016/j.freeradbiomed.2010.11.026} } @article{chen2012-23122958, author = {Chen, R. and Zhang, J. and Wu, Y. and Wang, D. and Feng, G. and Tang, Y. P. and Teng, Z. and Chen, C.}, title = {{Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease}}, journal = {Cell reports}, year = {2012}, doi = {10.1016/j.celrep.2012.09.030}, pmid = {23122958}, url = {https://doi.org/10.1016/j.celrep.2012.09.030} } @article{demr2026-42784125, author = {Demır, Ülkü Figen and Dilbaz, Fatmanur Karakuş}, title = {{Anti-Amyloid Monoclonal Antibodies in Early Alzheimer Disease: Lecanemab and Donanemab}}, journal = {Neurology International}, year = {2026}, doi = {10.3390/neurolint18090171}, pmid = {42784125}, url = {https://doi.org/10.3390/neurolint18090171} } @article{smith2025-39893139, author = {Smith, Eric Edward and Phillips, Natalie A. and Feldman, Howard and BORRIE, MICHAEL J. and Ganesh, Aravind and Henri‐Bhargava, Alexandre and Desmarais, Philippe and Frank, Andrew and others}, title = {{Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research}}, journal = {The Journal of Prevention of Alzheimer s Disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100068}, pmid = {39893139}, url = {https://doi.org/10.1016/j.tjpad.2025.100068} } @article{vigneswaran2025-40506692, author = {Vigneswaran, Sinthujah and Vijverberg, Everard G.B. and Barkhof, Frederik and van de Giessen, Elsmarieke and Lemstra, Afina Willemina and Pijnenburg, Yolande A.L. and Teunissen, Charlotte Elisabeth and van der Flier, Wiesje M. and others}, title = {{“Real‐world” eligibility for anti‐amyloid treatment in a tertiary memory clinic setting}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70375}, pmid = {40506692}, url = {https://doi.org/10.1002/alz.70375} } @article{tunali2025-40081955, author = {Tunali, Ilke and Wang, Jian and Arora, Anupa and Kim, Min Jung and Shcherbinin, Sergey and Pontecorvo, Michael J. and Iaccarino, Leonardo}, title = {{Development and Validation of a 18 F-Flortaucipir PET Visual Stratification Method}}, journal = {Journal of Nuclear Medicine}, year = {2025}, doi = {10.2967/jnumed.124.268700}, pmid = {40081955}, url = {https://doi.org/10.2967/jnumed.124.268700} } @article{karsmaz2025-39964627, author = {Karışmaz, Abdülkadir and Soysal, Pınar and Eren, Rafet and Serin, İstemi and Bilgiç, İrem and Tanriverdi, Irem and Smith, Lee H.}, title = {{Clinical implication of anemia in older patients with dementia with lewy bodies}}, journal = {Aging Clinical and Experimental Research}, year = {2025}, doi = {10.1007/s40520-025-02958-0}, pmid = {39964627}, url = {https://doi.org/10.1007/s40520-025-02958-0} } @article{ottoy2025-40922096, author = {Ottoy, Julie and Owsicki, Nicole and Bilgel, Murat and Binette, Alexa Pichet and Salvadó, Gemma and Kang, Min Su and Cash, David M. and Ewers, Michael and others}, title = {{Recent advances in neuroimaging of Alzheimer's disease and related dementias}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70648}, pmid = {40922096}, url = {https://doi.org/10.1002/alz.70648} } @article{zhang2025-40660381, author = {Zhang, Jingjing and Kong, Guoqing and Yang, Jinyue and Pang, Lin and Li, Xiubin}, title = {{Pathological mechanisms and treatment progression of Alzheimer’s disease}}, journal = {European journal of medical research}, year = {2025}, doi = {10.1186/s40001-025-02886-9}, pmid = {40660381}, url = {https://doi.org/10.1186/s40001-025-02886-9} } @article{reddy2025-40586237, author = {Reddy, Mallika and Li, June and Pajewski, Nicholas M. and Gaussoin, Sarah A. and Bryan, Robert Nick and Nasrallah, Ilya M. and Tamura, Manjula Kurella}, title = {{Cerebral small vessel disease and effects of intensive versus standard blood pressure treatment on cardiovascular outcomes and adverse events}}, journal = {Journal of Hypertension}, year = {2025}, doi = {10.1097/hjh.0000000000004093}, pmid = {40586237}, url = {https://doi.org/10.1097/hjh.0000000000004093} } @article{zhu2025-39880200, author = {Zhu, Y. and Olchanski, N. and Freund, K. M. and Cohen, J. T. and Neumann, P. J. and Lin, P. J.}, title = {{Changes in Out-of-Pocket Drug Expenditures Among Medicare Beneficiaries With Dementia Under the Inflation Reduction Act: A Simulation Study}}, journal = {Value in Health}, year = {2025}, doi = {10.1016/j.jval.2025.01.008}, pmid = {39880200}, url = {https://doi.org/10.1016/j.jval.2025.01.008} } @article{kapasi2025-40825161, author = {Kapasi, A. and James, B. D. and Yu, L. and Sood, A. and Arvanitakis, Z. and Bennett, D. A. and Boyle, P. and Schneider, J. A.}, title = {{Mixed Pathologies and Cognitive Outcomes in Persons Considered for Anti-Amyloid Treatment Eligibility Assessment: A Community-Based Study}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000214004}, pmid = {40825161}, url = {https://doi.org/10.1212/wnl.0000000000214004} } @article{tian2017-28596794, author = {Tian, J. and Shi, J. and Li, T. and Li, L. and Wang, Z. and Li, X. and Lv, Z. and Zheng, Q. and others}, title = {{Efficacy and Safety of an Herbal Therapy in Patients with Amnestic Mild Cognitive Impairment: A 24-Week Randomized Phase III Trial}}, journal = {Evidence-based complementary and alternative medicine : eCAM}, year = {2017}, doi = {10.1155/2017/4251747}, pmid = {28596794}, url = {https://doi.org/10.1155/2017/4251747} } @article{ramkumar2016-27899849, author = {Ramkumar, S. and Raghunath, A. and Raghunath, S.}, title = {{Statin Therapy: Review of Safety and Potential Side Effects}}, journal = {Acta Cardiologica Sinica}, year = {2016}, doi = {10.6515/acs20160611a}, pmid = {27899849}, url = {https://doi.org/10.6515/acs20160611a} } @article{eid2019-30877021, author = {Eid, A. and Mhatre, I. and Richardson, JR.}, title = {{Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine}}, journal = {Pharmacology \& therapeutics}, year = {2019}, doi = {10.1016/j.pharmthera.2019.03.005}, pmid = {30877021}, url = {https://doi.org/10.1016/j.pharmthera.2019.03.005} } @article{mccurry2007-17287134, author = {McCurry, S. M. and Logsdon, R. G. and Teri, L. and Vitiello, M. V.}, title = {{Sleep disturbances in caregivers of persons with dementia: contributing factors and treatment implications}}, journal = {Sleep medicine reviews}, year = {2007}, doi = {10.1016/j.smrv.2006.09.002}, pmid = {17287134}, url = {https://doi.org/10.1016/j.smrv.2006.09.002} } @article{bosboom2004-15480840, author = {Bosboom, J. L. and Stoffers, D. and ECh, Wolters}, title = {{Cognitive dysfunction and dementia in Parkinson's disease}}, journal = {Journal of neural transmission (Vienna, Austria : 1996)}, year = {2004}, doi = {10.1007/s00702-004-0168-1}, pmid = {15480840}, url = {https://doi.org/10.1007/s00702-004-0168-1} } @article{obeid2006-16697371, author = {Obeid, R. and Herrmann, W.}, title = {{Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia}}, journal = {FEBS letters}, year = {2006}, doi = {10.1016/j.febslet.2006.04.088}, pmid = {16697371}, url = {https://doi.org/10.1016/j.febslet.2006.04.088} } @article{brown2011-20946471, author = {Brown, W. R. and Thore, C. R.}, title = {{Review: cerebral microvascular pathology in ageing and neurodegeneration}}, journal = {Neuropathology and applied neurobiology}, year = {2011}, doi = {10.1111/j.1365-2990.2010.01139.x}, pmid = {20946471}, url = {https://doi.org/10.1111/j.1365-2990.2010.01139.x} } @article{li2023-37517293, author = {Li, Y. and Xu, H. and Wang, H. and Yang, K. and Luan, J. and Wang, S.}, title = {{TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease}}, journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie}, year = {2023}, doi = {10.1016/j.biopha.2023.115218}, pmid = {37517293}, url = {https://doi.org/10.1016/j.biopha.2023.115218} }