% alzhub.org library filter % Source: https://alzhub.org/research?score_min=67&about=side-effects % 119 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{pascuallucas2025-41058018, author = {Pascual-Lucas, M. and Lacosta, A. M. and Montañés, M. and Canudas, J. and Loscos, J. and Monleón, I. and Allué, J. A. and Sarasa, L. and others}, title = {{Safety, tolerability, immunogenicity, and efficacy of ABvac40 active immunotherapy against Aβ40 in patients with mild cognitive impairment or very mild Alzheimer's disease: A randomized, double-blind, placebo-controlled phase 2 study}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70776}, pmid = {41058018}, url = {https://doi.org/10.1002/alz.70776} } @article{shulman2023-38012285, author = {Shulman, M. and Kong, J. and O'Gorman, J. and Ratti, E. and Rajagovindan, R. and Viollet, L. and Huang, E. and Sharma, S. and others}, title = {{TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease}}, journal = {Nature aging}, year = {2023}, doi = {10.1038/s43587-023-00523-w}, pmid = {38012285}, url = {https://doi.org/10.1038/s43587-023-00523-w} } @article{yunusa2019-30901041, author = {Yunusa, I. and Alsumali, A. and Garba, A. E. and Regestein, Q. R. and Eguale, T.}, title = {{Assessment of Reported Comparative Effectiveness and Safety of Atypical Antipsychotics in the Treatment of Behavioral and Psychological Symptoms of Dementia: A Network Meta-analysis}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.0828}, pmid = {30901041}, url = {https://doi.org/10.1001/jamanetworkopen.2019.0828} } @article{dantas2024-37978096, author = {Dantas, J. M. and Mutarelli, A. and Navalha, D. D. P. and Dagostin, C. S. and Romeiro, P. H. C. L. and Felix, N. and Nogueira, A. and Batista, S. and others}, title = {{Efficacy of anti-amyloid-ß monoclonal antibody therapy in early Alzheimer's disease: a systematic review and meta-analysis}}, journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology}, year = {2024}, doi = {10.1007/s10072-023-07194-w}, pmid = {37978096}, url = {https://doi.org/10.1007/s10072-023-07194-w} } @article{tariot2026-41579901, author = {Tariot, Pierre N and Lopera, Francisco S and Ríos-Romenets, Silvia and Sink, Kaycee M and Giraldo-Chica, Margarita and Acosta-Baena, Natalia and Villegas, Gustavo and Espinosa, Alejandro and others}, title = {{Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial}}, journal = {The Lancet. Neurology}, year = {2026}, doi = {10.1016/s1474-4422(25)00426-0}, pmid = {41579901}, url = {https://doi.org/10.1016/s1474-4422(25)00426-0} } @article{burns2021-34146512, author = {Burns, Daniel K and Alexander, Robert C and Welsh-Bohmer, Kathleen A and Culp, Meredith and Chiang, Carl and O'Neil, Janet and Evans, Rebecca M and Harrigan, Patrick and others}, title = {{Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial}}, journal = {The Lancet. Neurology}, year = {2021}, doi = {10.1016/s1474-4422(21)00043-0}, pmid = {34146512}, url = {https://doi.org/10.1016/s1474-4422(21)00043-0} } @article{avgerinos2021-33831607, author = {Avgerinos, K. I. and Ferrucci, L. and Kapogiannis, D.}, title = {{Effects of monoclonal antibodies against amyloid-β on clinical and biomarker outcomes and adverse event risks: A systematic review and meta-analysis of phase III RCTs in Alzheimer's disease}}, journal = {Ageing research reviews}, year = {2021}, doi = {10.1016/j.arr.2021.101339}, pmid = {33831607}, url = {https://doi.org/10.1016/j.arr.2021.101339} } @article{qiao2024-38429615, author = {Qiao, Y. and Gu, J. and Yu, M. and Chi, Y. and Ma, Y.}, title = {{Comparative Efficacy and Safety of Monoclonal Antibodies for Cognitive Decline in Patients with Alzheimer's Disease: A Systematic Review and Network Meta-Analysis}}, journal = {CNS drugs}, year = {2024}, doi = {10.1007/s40263-024-01067-2}, pmid = {38429615}, url = {https://doi.org/10.1007/s40263-024-01067-2} } @article{toda2024-39350371, author = {Toda, Y. and Iwatsubo, T. and Nakamura, Y. and Matsuda, N. and Miyata, M. and Jin, M. and Chen, T. and Kuribayashi, K. and others}, title = {{Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer's Disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.106}, pmid = {39350371}, url = {https://doi.org/10.14283/jpad.2024.106} } @article{menegazdealmeida2024-38879828, author = {Menegaz de Almeida, A. and Leite, M. and Lopes, L. M. and Gomes Lima, P. and Siegloch Barros, M. L. and Rocha Pinheiro, S. and Í, Andrade and Viana, P. and others}, title = {{Gantenerumab for early Alzheimer's disease: a systematic review and meta-analysis}}, journal = {Expert review of neurotherapeutics}, year = {2024}, doi = {10.1080/14737175.2024.2367016}, pmid = {38879828}, url = {https://doi.org/10.1080/14737175.2024.2367016} } @article{zimmer2025-40063015, author = {Zimmer, J. A. and Ardayfio, P. and Wang, H. and Khanna, R. and Evans, C. D. and Lu, M. and Sparks, J. and Andersen, S. and Lauzon, S. and Nery, E. S. M. and others}, title = {{Amyloid-Related Imaging Abnormalities With Donanemab in Early Symptomatic Alzheimer Disease: Secondary Analysis of the TRAILBLAZER-ALZ and ALZ 2 Randomized Clinical Trials}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.0065}, pmid = {40063015}, url = {https://doi.org/10.1001/jamaneurol.2025.0065} } @article{rashad2022-36611492, author = {Rashad, A. and Rasool, A. and Shaheryar, M. and Sarfraz, A. and Sarfraz, Z. and Robles-Velasco, K. and Cherrez-Ojeda, I.}, title = {{Donanemab for Alzheimer's Disease: A Systematic Review of Clinical Trials}}, journal = {Healthcare (Basel, Switzerland)}, year = {2022}, doi = {10.3390/healthcare11010032}, pmid = {36611492}, url = {https://doi.org/10.3390/healthcare11010032} } @article{chen2024-38567735, author = {Chen, T. and O'Gorman, J. and Castrillo-Viguera, C. and Rajagovindan, R. and Curiale, G. G. and Tian, Y. and Patel, D. and von Rosenstiel, P. and others}, title = {{Results from the long-term extension of PRIME: A randomized Phase 1b trial of aducanumab}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13755}, pmid = {38567735}, url = {https://doi.org/10.1002/alz.13755} } @article{hsu2025-40316479, author = {Hsu, C. W. and Hsu, T. W. and Kao, Y. C. and Lin, Y. H. and Thompson, T. and Carvalho, A. F. and Stubbs, B. and Tseng, P. T. and others}, title = {{The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100195}, pmid = {40316479}, url = {https://doi.org/10.1016/j.tjpad.2025.100195} } @article{matsunaga2015-25860130, author = {Matsunaga, S. and Kishi, T. and Iwata, N.}, title = {{Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis}}, journal = {PloS one}, year = {2015}, doi = {10.1371/journal.pone.0123289}, pmid = {25860130}, url = {https://doi.org/10.1371/journal.pone.0123289} } @article{bateman2025-40120616, author = {Bateman, Randall J and Li, Yan and McDade, Eric M and Llibre-Guerra, Jorge J and Clifford, David B and Atri, Alireza and Mills, Susan L and Santacruz, Anna M and others}, title = {{Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial}}, journal = {The Lancet. Neurology}, year = {2025}, doi = {10.1016/s1474-4422(25)00024-9}, pmid = {40120616}, url = {https://doi.org/10.1016/s1474-4422(25)00024-9} } @article{kehoe2021-34687634, author = {Kehoe, Patrick Gavin and Turner, Nicholas and Howden, Beth and Jarutyte, Lina and Clegg, Shona Louise and Malone, Ian Brian and Barnes, Josephine and Nielsen, Casper and others}, title = {{Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial}}, journal = {The Lancet. Neurology}, year = {2021}, doi = {10.1016/s1474-4422(21)00263-5}, pmid = {34687634}, url = {https://doi.org/10.1016/s1474-4422(21)00263-5} } @article{schneider2005-16234500, author = {Schneider, L. S. and Dagerman, K. S. and Insel, P.}, title = {{Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials}}, journal = {JAMA}, year = {2005}, doi = {10.1001/jama.294.15.1934}, pmid = {16234500}, url = {https://doi.org/10.1001/jama.294.15.1934} } @article{winblad2008-18322263, author = {Winblad, B. and Gauthier, S. and Scinto, L. and Feldman, H. and Wilcock, G. K. and Truyen, L. and Mayorga, A. J. and Wang, D. and others}, title = {{Safety and efficacy of galantamine in subjects with mild cognitive impairment}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000303815.69777.26}, pmid = {18322263}, url = {https://doi.org/10.1212/01.wnl.0000303815.69777.26} } @article{hannestad2021-33967047, author = {Hannestad, Jonas and Duclos, Tiffanie and Chao, Whitney and Koborsi, Katie and Klutzaritz, Vicki and Beck, Brian and Patel, Ashok K and Scott, James and others}, title = {{Safety and Tolerability of GRF6019 Infusions in Severe Alzheimer's Disease: A Phase II Double-Blind Placebo-Controlled Trial}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2021}, doi = {10.3233/jad-210011}, pmid = {33967047}, url = {https://doi.org/10.3233/jad-210011} } @article{costa2022-34942135, author = {Costa, Alberto C S and Brandão, Ana C and Boada, Richard and Barrionuevo, Veridiana L and Taylor, Hudson G and Roth, Elizabeth and Stasko, Melissa R and Johnson, Mark W and others}, title = {{Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial}}, journal = {The Lancet. Neurology}, year = {2022}, doi = {10.1016/s1474-4422(21)00369-0}, pmid = {34942135}, url = {https://doi.org/10.1016/s1474-4422(21)00369-0} } @article{cummings2026-c800c391, author = {Cummings, J. L. and Atri, A. and Scheltens, P. and others}, title = {{Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (EVOKE and EVOKE+): two phase 3, randomised, placebo-controlled trials}}, journal = {The Lancet}, year = {2026}, doi = {10.1016/s0140-6736(26)00459-9}, pmid = {41865758}, url = {https://doi.org/10.1016/s0140-6736(26)00459-9} } @article{ostrowitzki2022-36121669, author = {Ostrowitzki, S. and Bittner, T. and Sink, K. M. and Mackey, H. and Rabe, C. and Honig, L. S. and Cassetta, E. and Woodward, M. and others}, title = {{Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.2909}, pmid = {36121669}, url = {https://doi.org/10.1001/jamaneurol.2022.2909} } @article{moayyedi2019-31152740, author = {Moayyedi, P. and Eikelboom, J. W. and Bosch, J. and Connolly, S. J. and Dyal, L. and Shestakovska, O. and Leong, D. and Anand, S. S. and others}, title = {{Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin}}, journal = {Gastroenterology}, year = {2019}, doi = {10.1053/j.gastro.2019.05.056}, pmid = {31152740}, url = {https://doi.org/10.1053/j.gastro.2019.05.056} } @article{cummings2025-39780249, author = {Cummings, J. L. and Atri, A. and Feldman, H. H. and Hansson, O. and Sano, M. and Knop, F. K. and Johannsen, P. and León, T. and others}, title = {{evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-024-01666-7}, pmid = {39780249}, url = {https://doi.org/10.1186/s13195-024-01666-7} } @article{penninkilampi2017-28025724, author = {Penninkilampi, R. and Brothers, H. M. and Eslick, G. D.}, title = {{Safety and Efficacy of Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: A Systematic Review and Meta-Analysis}}, journal = {Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology}, year = {2017}, doi = {10.1007/s11481-016-9722-5}, pmid = {28025724}, url = {https://doi.org/10.1007/s11481-016-9722-5} } @article{shim2026-41352683, author = {Shim, G. H. and Lau, E. C. Y. and Huynh, A. L. H. and Lu, C. Y. and Tan, E. C. K.}, title = {{Influence of patient characteristics on efficacy and safety of anti-amyloid monoclonal antibodies in Alzheimer's disease: A systematic review and meta-analysis}}, journal = {Ageing research reviews}, year = {2026}, doi = {10.1016/j.arr.2025.102981}, pmid = {41352683}, url = {https://doi.org/10.1016/j.arr.2025.102981} } @article{greeley2025-40912996, author = {Greeley, David and Nash, Marshall and Herskowitz, Brad and Kim, Fred and Rock, James and Prins, Neils and Kim, SangYun and Xi, Tianyang and others}, title = {{A phase 2 randomized, placebo-controlled study on the efficacy and safety of AR1001, a phosphodiesterase-5 inhibitor, in patients with mild-to-moderate Alzheimer's disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100337}, pmid = {40912996}, url = {https://doi.org/10.1016/j.tjpad.2025.100337} } @article{rosenbloom2021-33719017, author = {Rosenbloom, Michael and Barclay, Terry R and Kashyap, Bhavani and Hage, Lyndsay and O'Keefe, Lauren R and Svitak, Aleta and Pyle, Maria and Frey, William and others}, title = {{A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease}}, journal = {Drugs \& aging}, year = {2021}, doi = {10.1007/s40266-021-00845-7}, pmid = {33719017}, url = {https://doi.org/10.1007/s40266-021-00845-7} } @article{wilkinson2014-25297016, author = {Wilkinson, David and Windfeld, Kristian and Colding-Jørgensen, Eskild}, title = {{Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial}}, journal = {The Lancet. Neurology}, year = {2014}, doi = {10.1016/s1474-4422(14)70198-x}, pmid = {25297016}, url = {https://doi.org/10.1016/s1474-4422(14)70198-x} } @article{maher2011-21954480, author = {Maher, A. R. and Maglione, M. and Bagley, S. and Suttorp, M. and Hu, J. H. and Ewing, B. and Wang, Z. and Timmer, M. and others}, title = {{Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis}}, journal = {JAMA}, year = {2011}, doi = {10.1001/jama.2011.1360}, pmid = {21954480}, url = {https://doi.org/10.1001/jama.2011.1360} } @article{jeremic2023-37423541, author = {Jeremic, D. and Navarro-López, J. D. and Jiménez-Díaz, L.}, title = {{Efficacy and safety of anti-amyloid-β monoclonal antibodies in current Alzheimer's disease phase III clinical trials: A systematic review and interactive web app-based meta-analysis}}, journal = {Ageing research reviews}, year = {2023}, doi = {10.1016/j.arr.2023.102012}, pmid = {37423541}, url = {https://doi.org/10.1016/j.arr.2023.102012} } @article{teng2022-35696185, author = {Teng, E. and Manser, P. T. and Pickthorn, K. and Brunstein, F. and Blendstrup, M. and Sanabria Bohorquez, S. and Wildsmith, K. R. and Toth, B. and others}, title = {{Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.1375}, pmid = {35696185}, url = {https://doi.org/10.1001/jamaneurol.2022.1375} } @article{ketter2017-28269765, author = {Ketter, N. and Brashear, H. R. and Bogert, J. and Di, J. and Miaux, Y. and Gass, A. and Purcell, D. D. and Barkhof, F. and others}, title = {{Central Review of Amyloid-Related Imaging Abnormalities in Two Phase III Clinical Trials of Bapineuzumab in Mild-To-Moderate Alzheimer's Disease Patients}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-160216}, pmid = {28269765}, url = {https://doi.org/10.3233/jad-160216} } @article{kavirajan2007-17689146, author = {Kavirajan, H. and Schneider, L. S.}, title = {{Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials}}, journal = {The Lancet. Neurology}, year = {2007}, doi = {10.1016/s1474-4422(07)70195-3}, pmid = {17689146}, url = {https://doi.org/10.1016/s1474-4422(07)70195-3} } @article{ballard2009-19138567, author = {Ballard, C. and Hanney, M. L. and Theodoulou, M. and Douglas, S. and McShane, R. and Kossakowski, K. and Gill, R. and Juszczak, E. and others}, title = {{The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial}}, journal = {The Lancet. Neurology}, year = {2009}, doi = {10.1016/s1474-4422(08)70295-3}, pmid = {19138567}, url = {https://doi.org/10.1016/s1474-4422(08)70295-3} } @article{koh2021-33771205, author = {Koh, Seong-Ho and Kwon, Hyuk Sung and Choi, Seong Hye and Jeong, Jee Hyang and Na, Hae Ri and Lee, Chan Nyoung and Yang, YoungSoon and Lee, Ae Young and others}, title = {{Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer's disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00803-w}, pmid = {33771205}, url = {https://doi.org/10.1186/s13195-021-00803-w} } @article{craft2020-32568367, author = {Craft, S. and Raman, R. and Chow, T. W. and Rafii, M. S. and Sun, C. K. and Rissman, R. A. and Donohue, M. C. and Brewer, J. B. and others}, title = {{Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.1840}, pmid = {32568367}, url = {https://doi.org/10.1001/jamaneurol.2020.1840} } @article{salloway2025-39556389, author = {Salloway, S. and Wojtowicz, J. and Voyle, N. and Lane, C. A. and Klein, G. and Lyons, M. and Rossomanno, S. and Mazzo, F. and others}, title = {{Amyloid-Related Imaging Abnormalities (ARIA) in Clinical Trials of Gantenerumab in Early Alzheimer Disease}}, journal = {JAMA neurology}, year = {2025}, doi = {10.1001/jamaneurol.2024.3937}, pmid = {39556389}, url = {https://doi.org/10.1001/jamaneurol.2024.3937} } @article{gray2015-25621434, author = {Gray, S. L. and Anderson, M. L. and Dublin, S. and Hanlon, J. T. and Hubbard, R. and Walker, R. and Yu, O. and Crane, P. K. and others}, title = {{Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study}}, journal = {JAMA internal medicine}, year = {2015}, doi = {10.1001/jamainternmed.2014.7663}, pmid = {25621434}, url = {https://doi.org/10.1001/jamainternmed.2014.7663} } @article{salloway2018-30129411, author = {Salloway, S. and Marshall, G. A. and Lu, M. and Brashear, H. R.}, title = {{Long-Term Safety and Efficacy of Bapineuzumab in Patients with Mild-to-Moderate Alzheimer's Disease: A Phase 2, Open-Label Extension Study}}, journal = {Current Alzheimer research}, year = {2018}, doi = {10.2174/1567205015666180821114813}, pmid = {30129411}, url = {https://doi.org/10.2174/1567205015666180821114813} } @article{neve2024-39177596, author = {Neve, A. and Das, B. and Wojtowicz, J. and Huang, Z. and Bullain, S. and Watkin, M. and Lott, D. and Bittner, T. and others}, title = {{Long-Term Safety of Gantenerumab in Participants with Alzheimer's Disease: A Phase III, Double-Blind, and Open-Label Extension Study (Marguerite RoAD)}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2024}, doi = {10.3233/jad-240221}, pmid = {39177596}, url = {https://doi.org/10.3233/jad-240221} } @article{gwizdala2021-33856613, author = {Gwizdala, Kathryn L and Ferguson, David P and Kovan, Jeffery and Novak, Vera and Pontifex, Matthew B}, title = {{Placebo controlled phase II clinical trial: Safety and efficacy of combining intranasal insulin \& acute exercise}}, journal = {Metabolic brain disease}, year = {2021}, doi = {10.1007/s11011-021-00727-2}, pmid = {33856613}, url = {https://doi.org/10.1007/s11011-021-00727-2} } @article{mok2024-38631737, author = {Mok, P. L. H. and Carr, M. J. and Guthrie, B. and Morales, D. R. and Sheikh, A. and Elliott, R. A. and Camacho, E. M. and van Staa, T. and Avery, A. J. and Ashcroft, D. M.}, title = {{Multiple adverse outcomes associated with antipsychotic use in people with dementia: population based matched cohort study}}, journal = {BMJ}, year = {2024}, doi = {10.1136/bmj-2023-076268}, pmid = {38631737}, url = {https://doi.org/10.1136/bmj-2023-076268} } @article{wang2025-40172303, author = {Wang, H. and Serap Monkul Nery, E. and Ardayfio, P. and Khanna, R. and Otero Svaldi, D. and Gueorguieva, I. and Shcherbinin, S. and Andersen, S. W. and Hauck, P. M. and Engle, S. E. and others}, title = {{Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70062}, pmid = {40172303}, url = {https://doi.org/10.1002/alz.70062} } @article{sampson2007-17006875, author = {Sampson, E. L. and Raven, P. R. and Ndhlovu, P. N. and Vallance, A. and Garlick, N. and Watts, J. and Blanchard, M. R. and Bruce, A. and others}, title = {{A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement}}, journal = {International journal of geriatric psychiatry}, year = {2007}, doi = {10.1002/gps.1679}, pmid = {17006875}, url = {https://doi.org/10.1002/gps.1679} } @article{farlow2012-22672770, author = {Farlow, M. and Arnold, S. E. and van Dyck, C. H. and Aisen, P. S. and Snider, B. J. and Porsteinsson, A. P. and Friedrich, S. and Dean, R. A. and others}, title = {{Safety and biomarker effects of solanezumab in patients with Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2012}, doi = {10.1016/j.jalz.2011.09.224}, pmid = {22672770}, url = {https://doi.org/10.1016/j.jalz.2011.09.224} } @article{qiao2023-37213538, author = {Qiao, Y. and Chi, Y. and Zhang, Q. and Ma, Y.}, title = {{Safety and efficacy of lecanemab for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials}}, journal = {Frontiers in aging neuroscience}, year = {2023}, doi = {10.3389/fnagi.2023.1169499}, pmid = {37213538}, url = {https://doi.org/10.3389/fnagi.2023.1169499} } @article{hossain2024-38867460, author = {Hossain, M. F. and Husna, A. U. and Kharel, M.}, title = {{Use of lecanemab for the treatment of Alzheimer's disease: A systematic review}}, journal = {Brain and behavior}, year = {2024}, doi = {10.1002/brb3.3592}, pmid = {38867460}, url = {https://doi.org/10.1002/brb3.3592} } @article{farlow2019-30530975, author = {Farlow, Martin R and Thompson, Richard E and Wei, Lee-Jen and Tuchman, Alan J and Grenier, Elaine and Crockford, David and Wilke, Susanne and Benison, Jeffrey and others}, title = {{A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2019}, doi = {10.3233/jad-180759}, pmid = {30530975}, url = {https://doi.org/10.3233/jad-180759} } @article{ebell2024-38253509, author = {Ebell, M. H. and Barry, H. C. and Baduni, K. and Grasso, G.}, title = {{Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis}}, journal = {Annals of Family Medicine}, year = {2024}, doi = {10.1370/afm.3050}, pmid = {38253509}, url = {https://doi.org/10.1370/afm.3050} } @article{coric2012-22892585, author = {Coric, V. and van Dyck, C. H. and Salloway, S. and Andreasen, N. and Brody, M. and Richter, R. W. and Soininen, H. and Thein, S. and others}, title = {{Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease}}, journal = {Archives of neurology}, year = {2012}, doi = {10.1001/archneurol.2012.2194}, pmid = {22892585}, url = {https://doi.org/10.1001/archneurol.2012.2194} } @article{cummings2018-29695589, author = {Cummings, J. L. and Cohen, S. and van Dyck, C. H. and Brody, M. and Curtis, C. and Cho, W. and Ward, M. and Friesenhahn, M. and others}, title = {{ABBY: A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005550}, pmid = {29695589}, url = {https://doi.org/10.1212/wnl.0000000000005550} } @article{coupland2019-31233095, author = {Coupland, C. A. C. and Hill, T. and Dening, T. and Morriss, R. and Moore, M. and Hippisley-Cox, J.}, title = {{Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study}}, journal = {JAMA internal medicine}, year = {2019}, doi = {10.1001/jamainternmed.2019.0677}, pmid = {31233095}, url = {https://doi.org/10.1001/jamainternmed.2019.0677} } @article{thyrian2017-28746708, author = {Thyrian, JR. and Hertel, J. and Wucherer, D. and Eichler, T. and Michalowsky, B. and Dreier-Wolfgramm, A. and Zwingmann, I. and Kilimann, I. and others}, title = {{Effectiveness and Safety of Dementia Care Management in Primary Care: A Randomized Clinical Trial}}, journal = {JAMA psychiatry}, year = {2017}, doi = {10.1001/jamapsychiatry.2017.2124}, pmid = {28746708}, url = {https://doi.org/10.1001/jamapsychiatry.2017.2124} } @article{schneider2006-16505124, author = {Schneider, L. S. and Dagerman, K. and Insel, P. S.}, title = {{Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2006}, doi = {10.1097/01.jgp.0000200589.01396.6d}, pmid = {16505124}, url = {https://doi.org/10.1097/01.jgp.0000200589.01396.6d} } @article{zhong2007-17316169, author = {Zhong, K. X. and Tariot, P. N. and Mintzer, J. and Minkwitz, M. C. and Devine, N. A.}, title = {{Quetiapine to treat agitation in dementia: a randomized, double-blind, placebo-controlled study}}, journal = {Current Alzheimer research}, year = {2007}, doi = {10.2174/156720507779939805}, pmid = {17316169}, url = {https://doi.org/10.2174/156720507779939805} } @article{delnomdedieu2016-26925577, author = {Delnomdedieu, M. and Duvvuri, S. and Li, D. J. and Atassi, N. and Lu, M. and Brashear, H. R. and Liu, E. and Ness, S. and others}, title = {{First-In-Human safety and long-term exposure data for AAB-003 (PF-05236812) and biomarkers after intravenous infusions of escalating doses in patients with mild to moderate Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2016}, doi = {10.1186/s13195-016-0177-y}, pmid = {26925577}, url = {https://doi.org/10.1186/s13195-016-0177-y} } @article{chen2025-41070709, author = {Chen, S. and Ou, R. and Wei, Q. and Li, C. and Song, W. and Zhao, B. and Yang, J. and Fu, J. and others}, title = {{Lecanemab treatment for Alzheimer's Disease of varying severities and associated plasma biomarkers monitoring: A multi-center real-world study in China}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70750}, pmid = {41070709}, url = {https://doi.org/10.1002/alz.70750} } @article{rogers1996-8915035, author = {Rogers, S. L. and Friedhoff, L. T.}, title = {{The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial. The Donepezil Study Group}}, journal = {Dementia (Basel, Switzerland)}, year = {1996}, doi = {10.1159/000106895}, pmid = {8915035}, url = {https://doi.org/10.1159/000106895} } @article{lanctot2003-12975222, author = {Lanctôt, K. L. and Herrmann, N. and Yau, K. K. and Khan, L. R. and Liu, B. A. and LouLou, M. M. and Einarson, T. R.}, title = {{Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis}}, journal = {CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne}, year = {2003}, pmid = {12975222} } @article{mummery2026-41787076, author = {Mummery, C. J. and Mayorga, A. J. and Simmons, A. and Chow, T. W. and Burgess, B. and Nguyen, T. and Gao, J. and Budda, B. and Park, L. Q. and Gupta, R. and Li, C. and Shi, L. and others}, title = {{The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial}}, journal = {Nature Medicine}, year = {2026}, doi = {10.1038/s41591-026-04273-1}, pmid = {41787076}, url = {https://doi.org/10.1038/s41591-026-04273-1} } @article{sperling2021-33464300, author = {Sperling, R. and Henley, D. and Aisen, P. S. and Raman, R. and Donohue, M. C. and Ernstrom, K. and Rafii, M. S. and Streffer, J. and others}, title = {{Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial}}, journal = {JAMA neurology}, year = {2021}, doi = {10.1001/jamaneurol.2020.4857}, pmid = {33464300}, url = {https://doi.org/10.1001/jamaneurol.2020.4857} } @article{rege2021-33763822, author = {Rege, Sanika and Carnahan, Ryan M and Johnson, Michael L and Chen, Hua and Holmes, Holly M and Aparasu, Rajender R}, title = {{Antipsychotic Initiation Among Older Dementia Patients Using Cholinesterase Inhibitors: A National Retrospective Cohort Study}}, journal = {Drugs \& aging}, year = {2021}, doi = {10.1007/s40266-021-00851-9}, pmid = {33763822}, url = {https://doi.org/10.1007/s40266-021-00851-9} } @article{fleisher2024-38386949, author = {Fleisher, A. S. and Munsie, L. M. and Perahia, D. G. S. and Andersen, S. W. and Higgins, I. A. and Hauck, P. M. and Lo, A. C. and Sims, JR. and others}, title = {{Assessment of Efficacy and Safety of Zagotenemab: Results From PERISCOPE-ALZ, a Phase 2 Study in Early Symptomatic Alzheimer Disease}}, journal = {Neurology}, year = {2024}, doi = {10.1212/wnl.0000000000208061}, pmid = {38386949}, url = {https://doi.org/10.1212/wnl.0000000000208061} } @article{filippi2022-35099507, author = {Filippi, M. and Cecchetti, G. and Spinelli, E. G. and Vezzulli, P. and Falini, A. and Agosta, F.}, title = {{Amyloid-Related Imaging Abnormalities and β-Amyloid-Targeting Antibodies: A Systematic Review}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2021.5205}, pmid = {35099507}, url = {https://doi.org/10.1001/jamaneurol.2021.5205} } @article{sha2019-30383097, author = {Sha, S. J. and Deutsch, G. K. and Tian, L. and Richardson, K. and Coburn, M. and Gaudioso, J. L. and Marcal, T. and Solomon, E. and others}, title = {{Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2018.3288}, pmid = {30383097}, url = {https://doi.org/10.1001/jamaneurol.2018.3288} } @article{wang2005-16319382, author = {Wang, P. S. and Schneeweiss, S. and Avorn, J. and Fischer, M. A. and Mogun, H. and Solomon, D. H. and Brookhart, M. A.}, title = {{Risk of death in elderly users of conventional vs. atypical antipsychotic medications}}, journal = {The New England journal of medicine}, year = {2005}, doi = {10.1056/nejmoa052827}, pmid = {16319382}, url = {https://doi.org/10.1056/nejmoa052827} } @article{gill2007-17548409, author = {Gill, S. S. and Bronskill, S. E. and Normand, S. L. and Anderson, G. M. and Sykora, K. and Lam, K. and Bell, C. M. and Lee, P. E. and others}, title = {{Antipsychotic drug use and mortality in older adults with dementia}}, journal = {Annals of internal medicine}, year = {2007}, doi = {10.7326/0003-4819-146-11-200706050-00006}, pmid = {17548409}, url = {https://doi.org/10.7326/0003-4819-146-11-200706050-00006} } @article{cummings2026-41865758, author = {Cummings, Jeffrey L and Atri, Alireza and Sano, Mary and Zetterberg, Henrik and Scheltens, Philip and Knop, Filip K and Johannsen, Peter and Wichmann, Christian Ahmad and others}, title = {{Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials}}, journal = {The Lancet}, year = {2026}, doi = {10.1016/s0140-6736(26)00459-9}, pmid = {41865758}, url = {https://doi.org/10.1016/s0140-6736(26)00459-9} } @article{ballard2006-16437455, author = {Ballard, C. and Waite, J.}, title = {{The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease}}, journal = {The Cochrane database of systematic reviews}, year = {2006}, doi = {10.1002/14651858.cd003476.pub2}, pmid = {16437455}, url = {https://doi.org/10.1002/14651858.cd003476.pub2} } @article{wang2025-40308765, author = {Wang, H. and Pan, J. and Zhang, M. and Tan, Z.}, title = {{Re-evaluation of the efficacy and safety of anti-Aβ monoclonal antibodies (lecanemab/donanemab) in the treatment of early Alzheimer's disease}}, journal = {Frontiers in pharmacology}, year = {2025}, doi = {10.3389/fphar.2025.1599048}, pmid = {40308765}, url = {https://doi.org/10.3389/fphar.2025.1599048} } @article{salloway2018-29914022, author = {Salloway, S. P. and Sperling, R. and Fox, N. C. and Sabbagh, M. N. and Honig, L. S. and Porsteinsson, A. P. and Rofael, H. and Ketter, N. and others}, title = {{Long-Term Follow Up of Patients with Mild-to-Moderate Alzheimer's Disease Treated with Bapineuzumab in a Phase III, Open-Label, Extension Study}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2018}, doi = {10.3233/jad-171157}, pmid = {29914022}, url = {https://doi.org/10.3233/jad-171157} } @article{abdelazim2024-38565747, author = {Abdelazim, K. and Allam, A. A. and Afifi, B. and Abdulazeem, H. and Elbehiry, A. I.}, title = {{The efficacy and safety of lecanemab 10 mg/kg biweekly compared to a placebo in patients with Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials}}, journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology}, year = {2024}, doi = {10.1007/s10072-024-07477-w}, pmid = {38565747}, url = {https://doi.org/10.1007/s10072-024-07477-w} } @article{chundu2025-40621323, author = {Chundu, U. C. and Thiriveedhi, SR. and Bhatti, C. and Mupparaju, J. S. and Otinashvili, N. and Gelishvili, E.}, title = {{A Systematic Review of the Efficacy and Safety of Anti-amyloid Monoclonal Antibodies in Alzheimer's Disease}}, journal = {Cureus}, year = {2025}, doi = {10.7759/cureus.85377}, pmid = {40621323}, url = {https://doi.org/10.7759/cureus.85377} } @article{noguchishinohara2025-41276859, author = {Noguchi-Shinohara, M. and Yoshinobu, T. and Ozaki, T. and Muramatsu, D. and Shima, A. and Sakashita, Y. and Tada, Y. and Yamaguchi, H. and others}, title = {{Higher phosphorylated tau levels predict cognitive decline and amyloid-related imaging abnormalities during lecanemab treatment: clinical practice data}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-025-01912-6}, pmid = {41276859}, url = {https://doi.org/10.1186/s13195-025-01912-6} } @article{paczynski2025-40354064, author = {Paczynski, M. and Hofmann, A. and Posey, Z. and Gregersen, M. and Rudman, M. and Ellington, D. and Aldinger, M. and Musiek, E. S. and Holtzman, D. M. and Bateman, R. J. and others}, title = {{Lecanemab Treatment in a Specialty Memory Clinic}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.1232}, pmid = {40354064}, url = {https://doi.org/10.1001/jamaneurol.2025.1232} } @article{rafii2022-35532913, author = {Rafii, M. S. and Sol, O. and Mobley, W. C. and Delpretti, S. and Skotko, B. G. and Burke, A. D. and Sabbagh, M. N. and Yuan, S. H. and others}, title = {{Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.0983}, pmid = {35532913}, url = {https://doi.org/10.1001/jamaneurol.2022.0983} } @article{jeong2025-40112274, author = {Jeong, S. Y. and Suh, C. H. and Lim, J. S. and Shim, W. H. and Heo, H. and Choi, Y. and Kim, H. S. and Kim, S. J. and others}, title = {{Incidence of Amyloid-Related Imaging Abnormalities in Phase III Clinical Trials of Anti-Amyloid-β Immunotherapy: An Updated Meta-Analysis}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213483}, pmid = {40112274}, url = {https://doi.org/10.1212/wnl.0000000000213483} } @article{maust2015-25786075, author = {Maust, D. T. and Kim, H. M. and Seyfried, L. S. and Chiang, C. and Kavanagh, J. and Schneider, L. S. and Kales, H. C.}, title = {{Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm}}, journal = {JAMA psychiatry}, year = {2015}, doi = {10.1001/jamapsychiatry.2014.3018}, pmid = {25786075}, url = {https://doi.org/10.1001/jamapsychiatry.2014.3018} } @article{richardson2018-29695481, author = {Richardson, K. and Fox, C. and Maidment, I. and Steel, N. and Loke, Y. K. and Arthur, A. and Myint, P. K. and Grossi, C. M. and others}, title = {{Anticholinergic drugs and risk of dementia: case-control study}}, journal = {BMJ (Clinical research ed.)}, year = {2018}, doi = {10.1136/bmj.k1315}, pmid = {29695481}, url = {https://doi.org/10.1136/bmj.k1315} } @article{lacorte2022-35275549, author = {Lacorte, E. and Ancidoni, A. and Zaccaria, V. and Remoli, G. and Tariciotti, L. and Bellomo, G. and Sciancalepore, F. and Corbo, M. and others}, title = {{Safety and Efficacy of Monoclonal Antibodies for Alzheimer's Disease: A Systematic Review and Meta-Analysis of Published and Unpublished Clinical Trials}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2022}, doi = {10.3233/jad-220046}, pmid = {35275549}, url = {https://doi.org/10.3233/jad-220046} } @article{villain2022-36184326, author = {Villain, N. and Planche, V. and Levy, R.}, title = {{High-clearance anti-amyloid immunotherapies in Alzheimer's disease. Part 1: Meta-analysis and review of efficacy and safety data, and medico-economical aspects}}, journal = {Revue neurologique}, year = {2022}, doi = {10.1016/j.neurol.2022.06.012}, pmid = {36184326}, url = {https://doi.org/10.1016/j.neurol.2022.06.012} } @article{green2019-30652263, author = {Green, A. R. and Reifler, L. M. and Bayliss, E. A. and Weffald, L. A. and Boyd, C. M.}, title = {{Drugs Contributing to Anticholinergic Burden and Risk of Fall or Fall-Related Injury among Older Adults with Mild Cognitive Impairment, Dementia and Multiple Chronic Conditions: A Retrospective Cohort Study}}, journal = {Drugs \& aging}, year = {2019}, doi = {10.1007/s40266-018-00630-z}, pmid = {30652263}, url = {https://doi.org/10.1007/s40266-018-00630-z} } @article{nguyen2018-30080934, author = {Nguyen, C. and Lairson, D. R. and Swartz, M. D. and Du, X. L.}, title = {{Risks of Major Long-Term Side Effects Associated with Androgen-Deprivation Therapy in Men with Prostate Cancer}}, journal = {Pharmacotherapy}, year = {2018}, doi = {10.1002/phar.2168}, pmid = {30080934}, url = {https://doi.org/10.1002/phar.2168} } @article{chen2024-38640313, author = {Chen, Yan and Lai, Min and Tao, Ming}, title = {{Evaluating the efficacy and safety of Alzheimer's disease drugs: A meta-analysis and systematic review}}, journal = {Medicine}, year = {2024}, doi = {10.1097/md.0000000000037799}, pmid = {38640313}, url = {https://doi.org/10.1097/md.0000000000037799} } @article{gao2024-38439609, author = {Gao, Yaqi and Liu, Yulin and Li, Yanfang}, title = {{Safety and efficacy of acetylcholinesterase inhibitors for Alzheimer's disease: A systematic review and meta-analysis}}, journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University}, year = {2024}, doi = {10.17219/acem/176051}, pmid = {38439609}, url = {https://doi.org/10.17219/acem/176051} } @article{carney2019-31921965, author = {Carney, Greg and Bassett, Ken and Wright, James M and Maclure, Malcolm and McGuire, Nicolette and Dormuth, Colin R}, title = {{Comparison of cholinesterase inhibitor safety in real-world practice}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2019}, doi = {10.1016/j.trci.2019.09.011}, pmid = {31921965}, url = {https://doi.org/10.1016/j.trci.2019.09.011} } @article{abouelmagd2025-41188985, author = {Abouelmagd, Moaz Elsayed and Almosilhy, Nereen A and Makhlouf, Hamdy A and Hassan, Amr K and Osman, Ahmed S A and Hindawi, Mahmoud Diaa and Elshahat, Ahmed and Alnajjar, Asmaa Zakria and others}, title = {{Comparative safety of cholinesterase inhibitors and memantine for dementia: a protocol for a network meta-analysis of randomized controlled trials}}, journal = {Systematic reviews}, year = {2025}, doi = {10.1186/s13643-025-02961-6}, pmid = {41188985}, url = {https://doi.org/10.1186/s13643-025-02961-6} } @article{sheehan2015-26330451, author = {Sheehan, Rory and Hassiotis, Angela and Walters, Kate R and Osborn, David and Strydom, André and Horsfall, Laura}, title = {{Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study}}, journal = {BMJ}, year = {2015}, doi = {10.1136/bmj.h4326}, pmid = {26330451}, url = {https://doi.org/10.1136/bmj.h4326} } @article{geldmacher2011-20837824, author = {Geldmacher, D. S. and Fritsch, T. and McClendon, M. J. and Landreth, G.}, title = {{A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2010.229}, pmid = {20837824}, url = {https://doi.org/10.1001/archneurol.2010.229} } @article{ancelin2006-16452102, author = {Ancelin, M. L. and Artero, S. and Portet, F. and Dupuy, A. M. and Touchon, J. and Ritchie, K.}, title = {{Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study}}, journal = {BMJ (Clinical research ed.)}, year = {2006}, doi = {10.1136/bmj.38740.439664.de}, pmid = {16452102}, url = {https://doi.org/10.1136/bmj.38740.439664.de} } @article{dubois2012-22915447, author = {Dubois, B. and Tolosa, E. and Katzenschlager, R. and Emre, M. and Lees, A. J. and Schumann, G. and Pourcher, E. and Gray, J. and others}, title = {{Donepezil in Parkinson's disease dementia: a randomized, double-blind efficacy and safety study}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2012}, doi = {10.1002/mds.25098}, pmid = {22915447}, url = {https://doi.org/10.1002/mds.25098} } @article{rahman2023-36775284, author = {Rahman, Afroza and Hossen, Md Anwar and Chowdhury, Mirza Farhana Iqbal and Bari, Sadia and Tamanna, Nuzhat and Sultana, Syeda Salima and Haque, Sharar Naiarin and Masud, Abdullah Al and others}, title = {{Aducanumab for the treatment of Alzheimer's disease: a systematic review}}, journal = {Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society}, year = {2023}, doi = {10.1111/psyg.12944}, pmid = {36775284}, url = {https://doi.org/10.1111/psyg.12944} } @article{shang2025-41250246, author = {Shang, Jia and Zhong, Siyan and Shang, Li and Zeng, Qingze and Zhao, Shuai and Luo, Xiao and Li, Kaicheng and Zhang, Xinyi and others}, title = {{Real-world application of lecanemab in early-stage alzheimer's disease: a single-center prospective cohort analysis}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-025-01886-5}, pmid = {41250246}, url = {https://doi.org/10.1186/s13195-025-01886-5} } @article{shimasaki2026-41936348, author = {Shimasaki, Ryosuke and Kurihara, Masanori and Bannai, Taro and Hatano, Keiko and Suzuki, Fumio and Tokumaru, Aya Midori and Ishii, Kenji and Ihara, Ryoko and others}, title = {{Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100562}, pmid = {41936348}, url = {https://doi.org/10.1016/j.tjpad.2026.100562} } @article{vanetten2026-912127c4, author = {van Etten, E. S. and others}, title = {{Amyloid-Related Imaging Abnormalities (ARIA) in Anti-Amyloid Therapies for Alzheimer's Disease: An Update from the Alzheimer's Association ARIA Workgroup}}, journal = {Alzheimer's \& Dementia}, year = {2026} } @article{fleisher2008-18695053, author = {Fleisher, A. S. and Raman, R. and Siemers, E. R. and Becerra, L. and Clark, C. M. and Dean, R. A. and Farlow, M. R. and Galvin, J. E. and others}, title = {{Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease}}, journal = {Archives of neurology}, year = {2008}, doi = {10.1001/archneur.65.8.1031}, pmid = {18695053}, url = {https://doi.org/10.1001/archneur.65.8.1031} } @article{watt2020-32546202, author = {Watt, J. A. and Goodarzi, Z. and Veroniki, A. A. and Nincic, V. and Khan, P. A. and Ghassemi, M. and Thompson, Y. and Lai, Y. and others}, title = {{Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysis}}, journal = {BMC geriatrics}, year = {2020}, doi = {10.1186/s12877-020-01607-7}, pmid = {32546202}, url = {https://doi.org/10.1186/s12877-020-01607-7} } @article{billiotidegage2014-25208536, author = {Billioti de Gage, S. and Moride, Y. and Ducruet, T. and Kurth, T. and Verdoux, H. and Tournier, M. and Pariente, A. and Bégaud, B.}, title = {{Benzodiazepine use and risk of Alzheimer's disease: case-control study}}, journal = {BMJ (Clinical research ed.)}, year = {2014}, doi = {10.1136/bmj.g5205}, pmid = {25208536}, url = {https://doi.org/10.1136/bmj.g5205} } @article{jeong2022-36038268, author = {Jeong, S. Y. and Suh, C. H. and Shim, W. H. and Lim, J. S. and Lee, J. H. and Kim, S. J.}, title = {{Incidence of Amyloid-Related Imaging Abnormalities in Patients With Alzheimer Disease Treated With Anti-β-Amyloid Immunotherapy: A Meta-analysis}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201019}, pmid = {36038268}, url = {https://doi.org/10.1212/wnl.0000000000201019} } @article{herzig2016-26889839, author = {Herzig, S. J. and Rothberg, M. B. and Guess, JR. and Stevens, J. P. and Marshall, J. and Gurwitz, J. H. and Marcantonio, E. R.}, title = {{Antipsychotic Use in Hospitalized Adults: Rates, Indications, and Predictors}}, journal = {Journal of the American Geriatrics Society}, year = {2016}, doi = {10.1111/jgs.13943}, pmid = {26889839}, url = {https://doi.org/10.1111/jgs.13943} } @article{weintraub2016-26999262, author = {Weintraub, D. and Chiang, C. and Kim, H. M. and Wilkinson, J. and Marras, C. and Stanislawski, B. and Mamikonyan, E. and Kales, H. C.}, title = {{Association of Antipsychotic Use With Mortality Risk in Patients With Parkinson Disease}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.0031}, pmid = {26999262}, url = {https://doi.org/10.1001/jamaneurol.2016.0031} } @article{kim2011-21649634, author = {Kim, D. H. and Brown, R. T. and Ding, E. L. and Kiel, D. P. and Berry, S. D.}, title = {{Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of randomized controlled trials}}, journal = {Journal of the American Geriatrics Society}, year = {2011}, doi = {10.1111/j.1532-5415.2011.03450.x}, pmid = {21649634}, url = {https://doi.org/10.1111/j.1532-5415.2011.03450.x} } @article{arroyopacheco2025-39638097, author = {Arroyo-Pacheco, N. and Sarmiento-Blanco, S. and Vergara-Cadavid, G. and Castro-Leones, M. and Contreras-Puentes, N.}, title = {{Monoclonal therapy with lecanemab in the treatment of mild Alzheimer's disease: A systematic review and meta-analysis}}, journal = {Ageing research reviews}, year = {2025}, doi = {10.1016/j.arr.2024.102620}, pmid = {39638097}, url = {https://doi.org/10.1016/j.arr.2024.102620} } @article{andreasen2015-25789616, author = {Andreasen, N. and Simeoni, M. and Ostlund, H. and Lisjo, P. I. and Fladby, T. and Loercher, A. E. and Byrne, G. J. and Murray, F. and others}, title = {{First administration of the Fc-attenuated anti-β amyloid antibody GSK933776 to patients with mild Alzheimer's disease: a randomized, placebo-controlled study}}, journal = {PloS one}, year = {2015}, doi = {10.1371/journal.pone.0098153}, pmid = {25789616}, url = {https://doi.org/10.1371/journal.pone.0098153} } @article{martens2018-28956123, author = {Martens, R. M. and Bechten, A. and Ingala, S. and van Schijndel, R. A. and Machado, V. B. and de Jong, M. C. and Sanchez, E. and Purcell, D. and others}, title = {{The value of subtraction MRI in detection of amyloid-related imaging abnormalities with oedema or effusion in Alzheimer's patients: An interobserver study}}, journal = {European radiology}, year = {2018}, doi = {10.1007/s00330-017-5022-6}, pmid = {28956123}, url = {https://doi.org/10.1007/s00330-017-5022-6} } @article{islam2016-28013304, author = {Islam, M. M. and Iqbal, U. and Walther, B. and Atique, S. and Dubey, N. K. and Nguyen, P. A. and Poly, T. N. and Masud, J. H. and others}, title = {{Benzodiazepine Use and Risk of Dementia in the Elderly Population: A Systematic Review and Meta-Analysis}}, journal = {Neuroepidemiology}, year = {2016}, doi = {10.1159/000454881}, pmid = {28013304}, url = {https://doi.org/10.1159/000454881} } @article{schneider2006-17035647, author = {Schneider, L. S. and Tariot, P. N. and Dagerman, K. S. and Davis, S. M. and Hsiao, J. K. and Ismail, M. S. and Lebowitz, B. D. and Lyketsos, C. G. and others}, title = {{Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2006}, doi = {10.1056/nejmoa061240}, pmid = {17035647}, url = {https://doi.org/10.1056/nejmoa061240} } @article{wang2025-40619285, author = {Wang, Hong and Nery, Emel Serap Monkul and Ardayfio, Paul and Khanna, Rashna and Svaldi, Diana Otero and Shcherbinin, Sergey and Xu, Wen and Andersen, Scott W and others}, title = {{The effect of modified donanemab titration on amyloid-related imaging abnormalities with edema/effusions and amyloid reduction: 18-month results from TRAILBLAZER-ALZ 6}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100266}, pmid = {40619285}, url = {https://doi.org/10.1016/j.tjpad.2025.100266} } @article{liu2018-29429971, author = {Liu, E. and Wang, D. and Sperling, R. and Salloway, S. and Fox, N. C. and Blennow, K. and Scheltens, P. and Schmidt, M. E. and others}, title = {{Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005060}, pmid = {29429971}, url = {https://doi.org/10.1212/wnl.0000000000005060} } @article{matsunaga2018-30222469, author = {Matsunaga, Shinji and Kishi, Taro and Nomura, Ikuo and Sakuma, Kenji and Okuya, Makoto and Ikuta, Toshikazu and Iwata, Nakao}, title = {{The efficacy and safety of memantine for the treatment of Alzheimer's disease}}, journal = {Expert opinion on drug safety}, year = {2018}, doi = {10.1080/14740338.2018.1524870}, pmid = {30222469}, url = {https://doi.org/10.1080/14740338.2018.1524870} } @article{antolini2021-34531298, author = {Antolini, L. and DiFrancesco, J. C. and Zedde, M. and Basso, G. and Arighi, A. and Shima, A. and Cagnin, A. and Caulo, M. and others}, title = {{Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012778}, pmid = {34531298}, url = {https://doi.org/10.1212/wnl.0000000000012778} } @article{kishnani2009-19606472, author = {Kishnani, P. S. and Sommer, B. R. and Handen, B. L. and Seltzer, B. and Capone, G. T. and Spiridigliozzi, G. A. and Heller, J. H. and Richardson, S. and others}, title = {{The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome}}, journal = {American journal of medical genetics. Part A}, year = {2009}, doi = {10.1002/ajmg.a.32953}, pmid = {19606472}, url = {https://doi.org/10.1002/ajmg.a.32953} } @article{boon2025-41109234, author = {Boon, B. D. C. and Piura, Y. D. and Moloney, C. M. and Chalk, J. L. and Lincoln, S. J. and Rutledge, M. H. and Rothberg, D. M. and Kouri, N. and others}, title = {{Neuropathological changes and amyloid-related imaging abnormalities in Alzheimer's disease treated with aducanumab versus untreated: a retrospective case-control study}}, journal = {The Lancet. Neurology}, year = {2025}, doi = {10.1016/s1474-4422(25)00313-8}, pmid = {41109234}, url = {https://doi.org/10.1016/s1474-4422(25)00313-8} } @article{lonergan2007-17443602, author = {Lonergan, E. and Britton, A. M. and Luxenberg, J. and Wyller, T.}, title = {{Antipsychotics for delirium}}, journal = {The Cochrane database of systematic reviews}, year = {2007}, doi = {10.1002/14651858.cd005594.pub2}, pmid = {17443602}, url = {https://doi.org/10.1002/14651858.cd005594.pub2} } @article{vu2021-32723537, author = {Vu, M. and Sileanu, F. E. and Aspinall, S. L. and Niznik, J. D. and Springer, S. P. and Mor, M. K. and Zhao, X. and Ersek, M. and others}, title = {{Antihypertensive Deprescribing in Older Adult Veterans at End of Life Admitted to Veteran Affairs Nursing Homes}}, journal = {Journal of the American Medical Directors Association}, year = {2021}, doi = {10.1016/j.jamda.2020.05.060}, pmid = {32723537}, url = {https://doi.org/10.1016/j.jamda.2020.05.060} } @article{wang2022-35320578, author = {Wang, D. and Kowalewski, E. K. and Koch, G.}, title = {{Application of Meta-analysis to Evaluate Relationships Among ARIA-E Rate, Amyloid Reduction Rate, and Clinical Cognitive Response in Amyloid Therapeutic Clinical Trials for Early Alzheimer's Disease}}, journal = {Therapeutic innovation \& regulatory science}, year = {2022}, doi = {10.1007/s43441-022-00390-4}, pmid = {35320578}, url = {https://doi.org/10.1007/s43441-022-00390-4} } @article{kales2011-22193526, author = {Kales, Helen C. and Kim, Hyungjin Myra and Zivin, Kara and Valenstein, Marcia M. and Seyfried, Lisa S. and Chiang, Claire and Cunningham, Francesca E. and Schneider, Lon S. S. and others}, title = {{Risk of Mortality Among Individual Antipsychotics in Patients With Dementia}}, journal = {American Journal of Psychiatry}, year = {2011}, doi = {10.1176/appi.ajp.2011.11030347}, pmid = {22193526}, url = {https://doi.org/10.1176/appi.ajp.2011.11030347} }