% alzhub.org library filter % Source: https://alzhub.org/research?score_min=67&about=genetics % 233 entries, in the order the page lists them. Built from alzhub.org's own records. % 1 entries have no readable author in the source record and carry no author field. @article{mielke2026-42509652, author = {Mielke, Michelle M and Gaussoin, Sarah A and Casanova, Ramon and Latham, Lauren A and Manson, JoAnn E and Mouton, Charles P and Ng, Ted K S and Rapp, Stephen R and others}, title = {{Alzheimer's blood-based biomarkers, incident dementia, and interactions with age, APOE status, and hormone therapy}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71704}, pmid = {42509652}, url = {https://doi.org/10.1002/alz.71704} } @article{davies2015-25644384, author = {Davies, G. and Armstrong, N. and Bis, J. C. and Bressler, J. and Chouraki, V. and Giddaluru, S. and Hofer, E. and Ibrahim-Verbaas, C. A. and others}, title = {{Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949)}}, journal = {Molecular psychiatry}, year = {2015}, doi = {10.1038/mp.2014.188}, pmid = {25644384}, url = {https://doi.org/10.1038/mp.2014.188} } @article{fang2025-39806070, author = {Fang, M. and Hu, J. and Weiss, J. and Knopman, D. S. and Albert, M. and Windham, B. G. and Walker, K. A. and Sharrett, A. R. and Gottesman, R. F. and Lutsey, P. L. and others}, title = {{Lifetime risk and projected burden of dementia}}, journal = {Nature Medicine}, year = {2025}, doi = {10.1038/s41591-024-03340-9}, pmid = {39806070}, url = {https://doi.org/10.1038/s41591-024-03340-9} } @article{salloway2014-24450891, author = {Salloway, S. and Sperling, R. and Fox, N. C. and Blennow, K. and Klunk, W. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others}, title = {{Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2014}, doi = {10.1056/nejmoa1304839}, pmid = {24450891}, url = {https://doi.org/10.1056/nejmoa1304839} } @article{kunkle2019-30820047, author = {Kunkle, B. W. and Grenier-Boley, B. and Sims, R. and Bis, J. C. and Damotte, V. and Naj, A. C. and Boland, A. and Vronskaya, M. and others}, title = {{Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing}}, journal = {Nature genetics}, year = {2019}, doi = {10.1038/s41588-019-0358-2}, pmid = {30820047}, url = {https://doi.org/10.1038/s41588-019-0358-2} } @article{guerreiro2013-23150934, author = {Guerreiro, R. and Wojtas, A. and Bras, J. and Carrasquillo, M. and Rogaeva, E. and Majounie, E. and Cruchaga, C. and Sassi, C. and others}, title = {{TREM2 variants in Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2013}, doi = {10.1056/nejmoa1211851}, pmid = {23150934}, url = {https://doi.org/10.1056/nejmoa1211851} } @article{jansen2015-25988462, author = {Jansen, W. J. and Ossenkoppele, R. and Knol, D. L. and Tijms, B. M. and Scheltens, P. and Verhey, F. R. and Visser, P. J. and {Amyloid Biomarker Study Group} and others}, title = {{Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis}}, journal = {JAMA}, year = {2015}, doi = {10.1001/jama.2015.4668}, pmid = {25988462}, url = {https://doi.org/10.1001/jama.2015.4668} } @article{sakurai2024-38646854, author = {Sakurai, T. and Sugimoto, T. and Akatsu, H. and Doi, T. and Fujiwara, Y. and Hirakawa, A. and Kinoshita, F. and Kuzuya, M. and others}, title = {{Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13838}, pmid = {38646854}, url = {https://doi.org/10.1002/alz.13838} } @article{cammann2024-39108314, author = {Cammann, Davis B and Lu, Yimei and Rotter, Jerome I and Wood, Alexis C and Chen, Jingchun}, title = {{Polygenic scores and Mendelian randomization identify plasma proteins causally implicated in Alzheimer's disease}}, journal = {Frontiers in neuroscience}, year = {2024}, doi = {10.3389/fnins.2024.1404377}, pmid = {39108314}, url = {https://doi.org/10.3389/fnins.2024.1404377} } @article{saadmaan2024-38647197, author = {Saadmaan, Gazi and Dalmasso, Maria Carolina and Ramirez, Alfredo and Hiltunen, Mikko and Kemppainen, Nina and Lehtisalo, Jenni and Mangialasche, Francesca and Ngandu, Tiia and others}, title = {{Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13843}, pmid = {38647197}, url = {https://doi.org/10.1002/alz.13843} } @article{bai2021-34384464, author = {Bai, B. and Vanderwall, D. and Li, Y. and Wang, X. and Poudel, S. and Wang, H. and Dey, K. K. and Chen, P. C. and others}, title = {{Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery}}, journal = {Molecular neurodegeneration}, year = {2021}, doi = {10.1186/s13024-021-00474-z}, pmid = {34384464}, url = {https://doi.org/10.1186/s13024-021-00474-z} } @article{trpchevska2022-35580588, author = {Trpchevska, N. and Freidin, M. B. and Broer, L. and Oosterloo, B. C. and Yao, S. and Zhou, Y. and Vona, B. and Bishop, C. and others}, title = {{Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss}}, journal = {American journal of human genetics}, year = {2022}, doi = {10.1016/j.ajhg.2022.04.010}, pmid = {35580588}, url = {https://doi.org/10.1016/j.ajhg.2022.04.010} } @article{perry2026-41689888, author = {Perry, Richard and Kipps, Christopher and Martín, Maria Eugenia Soto and Bozzali, Marco and Logroscino, Giancarlo and Trafford, Sarah and Dhadda, Shobha and Kanekiyo, Michio and others}, title = {{Lecanemab for treatment of individuals with early Alzheimer's Disease (AD) who are apolipoprotein E ε4 (ApoE ε4) non-carriers or heterozygotes}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100507}, pmid = {41689888}, url = {https://doi.org/10.1016/j.tjpad.2026.100507} } @article{liu2025-40806132, author = {Liu, Yuxi and Fowler, Hailie and Wang, Dong D and Barnes, Lisa L and Cornelis, Marilyn C}, title = {{Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Trial: Genetic Resource for Precision Nutrition}}, journal = {Nutrients}, year = {2025}, doi = {10.3390/nu17152548}, pmid = {40806132}, url = {https://doi.org/10.3390/nu17152548} } @article{belloy2023-37930705, author = {Belloy, M. E. and Andrews, S. J. and Le Guen, Y. and Cuccaro, M. and Farrer, L. A. and Napolioni, V. and Greicius, M. D.}, title = {{APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry}}, journal = {JAMA Neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3599}, pmid = {37930705}, url = {https://doi.org/10.1001/jamaneurol.2023.3599} } @article{ossenkoppele2015-25988463, author = {Ossenkoppele, R. and Jansen, W. J. and Rabinovici, G. D. and Knol, D. L. and van der Flier, W. M. and van Berckel, B. N. and Scheltens, P. and Visser, P. J. and others}, title = {{Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis}}, journal = {JAMA}, year = {2015}, doi = {10.1001/jama.2015.4669}, pmid = {25988463}, url = {https://doi.org/10.1001/jama.2015.4669} } @article{naj2011-21460841, author = {Naj, A. C. and Jun, G. and Beecham, G. W. and Wang, L. S. and Vardarajan, B. N. and Buros, J. and Gallins, P. J. and Buxbaum, J. D. and others}, title = {{Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease}}, journal = {Nature genetics}, year = {2011}, doi = {10.1038/ng.801}, pmid = {21460841}, url = {https://doi.org/10.1038/ng.801} } @article{sims2017-28714976, author = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others}, title = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}}, journal = {Nature genetics}, year = {2017}, doi = {10.1038/ng.3916}, pmid = {28714976}, url = {https://doi.org/10.1038/ng.3916} } @article{shigemizu2022-35264725, author = {Shigemizu, Daichi and Asanomi, Yuya and Akiyama, Shintaro and Mitsumori, Risa and Niida, Shumpei and Ozaki, Kouichi}, title = {{Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2022}, doi = {10.1038/s41380-022-01483-0}, pmid = {35264725}, url = {https://doi.org/10.1038/s41380-022-01483-0} } @article{dumitrescu2019-31497858, author = {Dumitrescu, Logan and Barnes, Lisa L and Thambisetty, Madhav and Beecham, Gary and Kunkle, Brian and Bush, William S and Gifford, Katherine A and Chibnik, Lori B and others}, title = {{Sex differences in the genetic predictors of Alzheimer's pathology}}, journal = {Brain : a journal of neurology}, year = {2019}, doi = {10.1093/brain/awz206}, pmid = {31497858}, url = {https://doi.org/10.1093/brain/awz206} } @article{mews2024-38699333, author = {Mews, Makaela A and Naj, Adam C and Griswold, Anthony J and {Alzheimer’s Disease Genetics Consortium} and Below, Jennifer E and Bush, William S}, title = {{Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer's Disease}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2024}, doi = {10.1101/2024.04.17.24305737}, pmid = {38699333}, url = {https://doi.org/10.1101/2024.04.17.24305737} } @article{bellenguez2026-6dc8c8dc, author = {Bellenguez, C. and Lambert, J. C. and others}, title = {{Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias}}, journal = {Nature Genetics}, year = {2026} } @article{marioni2018-29777097, author = {Marioni, R. E. and Harris, S. E. and Zhang, Q. and McRae, A. F. and Hagenaars, S. P. and Hill, W. D. and Davies, G. and Ritchie, C. W. and others}, title = {{GWAS on family history of Alzheimer's disease}}, journal = {Translational psychiatry}, year = {2018}, doi = {10.1038/s41398-018-0150-6}, pmid = {29777097}, url = {https://doi.org/10.1038/s41398-018-0150-6} } @article{winblad2001-11502918, author = {Winblad, B. and Engedal, K. and Soininen, H. and Verhey, F. and Waldemar, G. and Wimo, A. and Wetterholm, A. L. and Zhang, R. and others}, title = {{A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD}}, journal = {Neurology}, year = {2001}, doi = {10.1212/wnl.57.3.489}, pmid = {11502918}, url = {https://doi.org/10.1212/wnl.57.3.489} } @article{savage2018-29942086, author = {Savage, J. E. and Jansen, P. R. and Stringer, S. and Watanabe, K. and Bryois, J. and de Leeuw, C. A. and Nagel, M. and Awasthi, S. and others}, title = {{Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence}}, journal = {Nature genetics}, year = {2018}, doi = {10.1038/s41588-018-0152-6}, pmid = {29942086}, url = {https://doi.org/10.1038/s41588-018-0152-6} } @article{liu2017-28092683, author = {Liu, J. Z. and Erlich, Y. and Pickrell, J. K.}, title = {{Case-control association mapping by proxy using family history of disease}}, journal = {Nature genetics}, year = {2017}, doi = {10.1038/ng.3766}, pmid = {28092683}, url = {https://doi.org/10.1038/ng.3766} } @article{wightman2021-34493870, author = {Wightman, D. P. and Jansen, I. E. and Savage, J. E. and Shadrin, A. A. and Bahrami, S. and Holland, D. and Rongve, A. and Børte, S. and others}, title = {{A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease}}, journal = {Nature genetics}, year = {2021}, doi = {10.1038/s41588-021-00921-z}, pmid = {34493870}, url = {https://doi.org/10.1038/s41588-021-00921-z} } @article{study2024-39046104, title = {{A genome-wide association meta-analysis of all-cause and vascular dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.14115}, pmid = {39046104}, url = {https://doi.org/10.1002/alz.14115} } @article{lupton2017-28582860, author = {Lupton, Michelle K and Benyamin, Beben and Proitsi, Petroula and Nyholt, Dale R and Ferreira, Manuel A and Montgomery, Grant W and Heath, Andrew C and Madden, Pamela A and others}, title = {{No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-170027}, pmid = {28582860}, url = {https://doi.org/10.3233/jad-170027} } @article{cai2018-30258348, author = {Cai, Qixuan and Xin, Zhuoyuan and Zuo, Lin and Li, Fan and Liu, Bin}, title = {{Alzheimer's Disease and Rheumatoid Arthritis: A Mendelian Randomization Study}}, journal = {Frontiers in neuroscience}, year = {2018}, doi = {10.3389/fnins.2018.00627}, pmid = {30258348}, url = {https://doi.org/10.3389/fnins.2018.00627} } @article{garatachea2015-975b7ad3, author = {Garatachea, Nuria and Marín, Pedro J. and Santos-Lozano, Alejandro and Sanchis-Gomar, Fabian and Emanuele, Enzo and Lucia, Alejandro}, title = {{The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis}}, journal = {Rejuvenation Research}, year = {2015}, doi = {10.1089/rej.2014.1605}, url = {https://doi.org/10.1089/rej.2014.1605} } @article{jun2016-25778476, author = {Jun, G. and Ibrahim-Verbaas, C. A. and Vronskaya, M. and Lambert, J. C. and Chung, J. and Naj, A. C. and Kunkle, B. W. and Wang, L. S. and others}, title = {{A novel Alzheimer disease locus located near the gene encoding tau protein}}, journal = {Molecular psychiatry}, year = {2016}, doi = {10.1038/mp.2015.23}, pmid = {25778476}, url = {https://doi.org/10.1038/mp.2015.23} } @article{snitz2009-20040554, author = {Snitz, B. E. and O'Meara, E. S. and Carlson, M. C. and Arnold, A. M. and Ives, D. G. and Rapp, SR. and Saxton, J. and Lopez, O. L. and others}, title = {{Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial}}, journal = {JAMA}, year = {2009}, doi = {10.1001/jama.2009.1913}, pmid = {20040554}, url = {https://doi.org/10.1001/jama.2009.1913} } @article{solomon2018-29356827, author = {Solomon, A. and Turunen, H. and Ngandu, T. and Peltonen, M. and Levälahti, E. and Helisalmi, S. and Antikainen, R. and Bäckman, L. and others}, title = {{Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2017.4365}, pmid = {29356827}, url = {https://doi.org/10.1001/jamaneurol.2017.4365} } @article{thompson2014-24399358, author = {Thompson, P. M. and Stein, J. L. and Medland, S. E. and Hibar, D. P. and Vasquez, A. A. and Renteria, M. E. and Toro, R. and Jahanshad, N. and others}, title = {{The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data}}, journal = {Brain imaging and behavior}, year = {2014}, doi = {10.1007/s11682-013-9269-5}, pmid = {24399358}, url = {https://doi.org/10.1007/s11682-013-9269-5} } @article{stein2012-22504417, author = {Stein, J. L. and Medland, S. E. and Vasquez, A. A. and Hibar, D. P. and Senstad, R. E. and Winkler, A. M. and Toro, R. and Appel, K. and others}, title = {{Identification of common variants associated with human hippocampal and intracranial volumes}}, journal = {Nature genetics}, year = {2012}, doi = {10.1038/ng.2250}, pmid = {22504417}, url = {https://doi.org/10.1038/ng.2250} } @article{klimentidis2018-29899525, author = {Klimentidis, Y. C. and Raichlen, D. A. and Bea, J. and Garcia, D. O. and Wineinger, N. E. and Mandarino, L. J. and Alexander, G. E. and Chen, Z. and others}, title = {{Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE}}, journal = {International journal of obesity (2005)}, year = {2018}, doi = {10.1038/s41366-018-0120-3}, pmid = {29899525}, url = {https://doi.org/10.1038/s41366-018-0120-3} } @article{guerreiro2018-29263008, author = {Guerreiro, R. and Ross, O. A. and Kun-Rodrigues, C. and Hernandez, D. G. and Orme, T. and Eicher, J. D. and Shepherd, C. E. and Parkkinen, L. and others}, title = {{Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(17)30400-3}, pmid = {29263008}, url = {https://doi.org/10.1016/s1474-4422(17)30400-3} } @article{pereiradasilva2025-40692324, author = {Pereira da Silva, A. M. and Falcão, L. and Virgilio, F. and Rodrigues Menezes, I. and Leite, M. and Farias, E. and Nascimento, M. and Lee Han, M. and others}, title = {{Efficacy and APOE ε4-stratified risk of donanemab in Alzheimer's disease: A systematic review and meta-analysis of randomized clinical trials}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2025}, doi = {10.1177/13872877251361044}, pmid = {40692324}, url = {https://doi.org/10.1177/13872877251361044} } @article{tanida2022-38469065, author = {Tanida, Kotomi and Shimada, Mihoko and Khor, Seik-Soon and Toyoda, Hiromi and Kato, Kayoko and Kotorii, Nozomu and Kotorii, Tatayu and Ariyoshi, Yu and others}, title = {{Genome-wide association study of idiopathic hypersomnia in a Japanese population}}, journal = {Sleep and biological rhythms}, year = {2022}, doi = {10.1007/s41105-021-00349-2}, pmid = {38469065}, url = {https://doi.org/10.1007/s41105-021-00349-2} } @article{lee2015-25037741, author = {Lee, Young Ho and Song, Gwan Gyu}, title = {{Genome-wide pathway analysis of a genome-wide association study on Alzheimer's disease}}, journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology}, year = {2015}, doi = {10.1007/s10072-014-1885-3}, pmid = {25037741}, url = {https://doi.org/10.1007/s10072-014-1885-3} } @article{kim2025-40175353, author = {Kim, Jun Pyo and Jung, Sang-Hyuk and Jang, Beomjin and Cho, Minyoung and Song, Minku and Kim, Jaeyoung and Kim, Beomsu and Lee, Hyunwoo and others}, title = {{Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition}}, journal = {Nature communications}, year = {2025}, doi = {10.1038/s41467-025-57751-4}, pmid = {40175353}, url = {https://doi.org/10.1038/s41467-025-57751-4} } @article{felsky2023-36462719, author = {Felsky, Daniel and Santa-Maria, Ismael and Cosacak, Mehmet Ilyas and French, Leon and Schneider, Julie A and Bennett, David A and De Jager, Philip L and Kizil, Caghan and others}, title = {{The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms}}, journal = {Neurobiology of disease}, year = {2023}, doi = {10.1016/j.nbd.2022.105938}, pmid = {36462719}, url = {https://doi.org/10.1016/j.nbd.2022.105938} } @article{littlejohns2017-28531320, author = {Littlejohns, Thomas J. and Sudlow, Cathie L. M. and Allen, Naomi E. and Collins, Rory}, title = {{UK Biobank: opportunities for cardiovascular research}}, journal = {European Heart Journal}, year = {2017}, doi = {10.1093/eurheartj/ehx254}, pmid = {28531320}, url = {https://doi.org/10.1093/eurheartj/ehx254} } @article{seshadri2010-20460622, author = {Seshadri, S. and Fitzpatrick, A. L. and Ikram, M. A. and DeStefano, A. L. and Gudnason, V. and Boada, M. and Bis, J. C. and Smith, A. V. and others}, title = {{Genome-wide analysis of genetic loci associated with Alzheimer disease}}, journal = {JAMA}, year = {2010}, doi = {10.1001/jama.2010.574}, pmid = {20460622}, url = {https://doi.org/10.1001/jama.2010.574} } @article{reitz2013-23571587, author = {Reitz, C. and Jun, G. and Naj, A. and Rajbhandary, R. and Vardarajan, B. N. and Wang, L. S. and Valladares, O. and Lin, C. F. and others}, title = {{Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans}}, journal = {JAMA}, year = {2013}, doi = {10.1001/jama.2013.2973}, pmid = {23571587}, url = {https://doi.org/10.1001/jama.2013.2973} } @article{kunkle2021-33074286, author = {Kunkle, B. W. and Schmidt, M. and Klein, H. U. and Naj, A. C. and Hamilton-Nelson, K. L. and Larson, E. B. and Evans, D. A. and De Jager, P. L. and others}, title = {{Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis}}, journal = {JAMA neurology}, year = {2021}, doi = {10.1001/jamaneurol.2020.3536}, pmid = {33074286}, url = {https://doi.org/10.1001/jamaneurol.2020.3536} } @article{lourida2019-31302669, author = {Lourida, I. and Hannon, E. and Littlejohns, T. J. and Langa, K. M. and Hyppönen, E. and Kuzma, E. and Llewellyn, D. J.}, title = {{Association of Lifestyle and Genetic Risk With Incidence of Dementia}}, journal = {JAMA}, year = {2019}, doi = {10.1001/jama.2019.9879}, pmid = {31302669}, url = {https://doi.org/10.1001/jama.2019.9879} } @article{ferrari2014-24943344, author = {Ferrari, R. and Hernandez, D. G. and Nalls, M. A. and Rohrer, J. D. and Ramasamy, A. and Kwok, J. B. and Dobson-Stone, C. and Brooks, W. S. and others}, title = {{Frontotemporal dementia and its subtypes: a genome-wide association study}}, journal = {The Lancet. Neurology}, year = {2014}, doi = {10.1016/s1474-4422(14)70065-1}, pmid = {24943344}, url = {https://doi.org/10.1016/s1474-4422(14)70065-1} } @article{hibar2017-28098162, author = {Hibar, D. P. and Adams, H. H. H. and Jahanshad, N. and Chauhan, G. and Stein, J. L. and Hofer, E. and Renteria, M. E. and Bis, J. C. and others}, title = {{Novel genetic loci associated with hippocampal volume}}, journal = {Nature communications}, year = {2017}, doi = {10.1038/ncomms13624}, pmid = {28098162}, url = {https://doi.org/10.1038/ncomms13624} } @article{bellenguez2022-afeff1fb, author = {Bellenguez, C. and Küçükali, F. and Jansen, I. E. and Kleineidam, L. and Moreno-Grau, S. and others}, title = {{New insights into the genetic etiology of Alzheimer's disease and related dementias}}, journal = {Nature Genetics}, year = {2022}, pmid = {35379992} } @article{lipnicki2019-31335910, author = {Lipnicki, D. M. and Makkar, SR. and Crawford, J. D. and Thalamuthu, A. and Kochan, N. A. and Lima-Costa, M. F. and Castro-Costa, E. and Ferri, C. P. and others}, title = {{Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study}}, journal = {PLoS medicine}, year = {2019}, doi = {10.1371/journal.pmed.1002853}, pmid = {31335910}, url = {https://doi.org/10.1371/journal.pmed.1002853} } @article{gordon2018-29397305, author = {Gordon, B. A. and Blazey, T. M. and Su, Y. and Hari-Raj, A. and Dincer, A. and Flores, S. and Christensen, J. and McDade, E. and others}, title = {{Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(18)30028-0}, pmid = {29397305}, url = {https://doi.org/10.1016/s1474-4422(18)30028-0} } @article{rovio2005-16239176, author = {Rovio, S. and Kåreholt, I. and Helkala, E. L. and Viitanen, M. and Winblad, B. and Tuomilehto, J. and Soininen, H. and Nissinen, A. and others}, title = {{Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease}}, journal = {The Lancet. Neurology}, year = {2005}, doi = {10.1016/s1474-4422(05)70198-8}, pmid = {16239176}, url = {https://doi.org/10.1016/s1474-4422(05)70198-8} } @article{arango2021-34505386, author = {Arango, C. and Dragioti, E. and Solmi, M. and Cortese, S. and Domschke, K. and Murray, R. M. and Jones, P. B. and Uher, R. and others}, title = {{Risk and protective factors for mental disorders beyond genetics: an evidence-based atlas}}, journal = {World psychiatry : official journal of the World Psychiatric Association (WPA)}, year = {2021}, doi = {10.1002/wps.20894}, pmid = {34505386}, url = {https://doi.org/10.1002/wps.20894} } @article{rajabli2025-40676597, author = {Rajabli, F. and Benchek, P. and Tosto, G. and Kushch, N. and Sha, J. and Bazemore, K. and Zhu, C. and Lee, W. P. and others}, title = {{Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease}}, journal = {Genome biology}, year = {2025}, doi = {10.1186/s13059-025-03564-z}, pmid = {40676597}, url = {https://doi.org/10.1186/s13059-025-03564-z} } @article{bertram2007-17192785, author = {Bertram, L. and McQueen, M. B. and Mullin, K. and Blacker, D. and Tanzi, R. E.}, title = {{Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database}}, journal = {Nature genetics}, year = {2007}, doi = {10.1038/ng1934}, pmid = {17192785}, url = {https://doi.org/10.1038/ng1934} } @article{shcherbinin2022-36094645, author = {Shcherbinin, S. and Evans, C. D. and Lu, M. and Andersen, S. W. and Pontecorvo, M. J. and Willis, B. A. and Gueorguieva, I. and Hauck, P. M. and others}, title = {{Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.2793}, pmid = {36094645}, url = {https://doi.org/10.1001/jamaneurol.2022.2793} } @article{bergeron2018-30255971, author = {Bergeron, D. and Gorno-Tempini, M. L. and Rabinovici, G. D. and Santos-Santos, M. A. and Seeley, W. and Miller, B. L. and Pijnenburg, Y. and Keulen, M. A. and others}, title = {{Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia}}, journal = {Annals of neurology}, year = {2018}, doi = {10.1002/ana.25333}, pmid = {30255971}, url = {https://doi.org/10.1002/ana.25333} } @article{lipnicki2017-28323832, author = {Lipnicki, D. M. and Crawford, J. D. and Dutta, R. and Thalamuthu, A. and Kochan, N. A. and Andrews, G. and Lima-Costa, M. F. and Castro-Costa, E. and others}, title = {{Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study}}, journal = {PLoS medicine}, year = {2017}, doi = {10.1371/journal.pmed.1002261}, pmid = {28323832}, url = {https://doi.org/10.1371/journal.pmed.1002261} } @article{xu2025-40067298, author = {Xu, X. and Kwon, J. and Yan, R. and Apio, C. and Song, S. and Heo, G. and Yang, Q. and Timsina, J. and others}, title = {{Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries}}, journal = {JAMA network open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.0562}, pmid = {40067298}, url = {https://doi.org/10.1001/jamanetworkopen.2025.0562} } @article{andrews2020-31986256, author = {Andrews, S. J. and Fulton-Howard, B. and Goate, A.}, title = {{Interpretation of risk loci from genome-wide association studies of Alzheimer's disease}}, journal = {The Lancet. Neurology}, year = {2020}, doi = {10.1016/s1474-4422(19)30435-1}, pmid = {31986256}, url = {https://doi.org/10.1016/s1474-4422(19)30435-1} } @article{ryman2014-24928124, author = {Ryman, D. C. and Acosta-Baena, N. and Aisen, P. S. and Bird, T. and Danek, A. and Fox, N. C. and Goate, A. and Frommelt, P. and others}, title = {{Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000596}, pmid = {24928124}, url = {https://doi.org/10.1212/wnl.0000000000000596} } @article{fornage2011-21681796, author = {Fornage, M. and Debette, S. and Bis, J. C. and Schmidt, H. and Ikram, M. A. and Dufouil, C. and Sigurdsson, S. and Lumley, T. and others}, title = {{Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22403}, pmid = {21681796}, url = {https://doi.org/10.1002/ana.22403} } @article{sherva2023-36543923, author = {Sherva, R. and Zhang, R. and Sahelijo, N. and Jun, G. and Anglin, T. and Chanfreau, C. and Cho, K. and Fonda, JR. and others}, title = {{African ancestry GWAS of dementia in a large military cohort identifies significant risk loci}}, journal = {Molecular psychiatry}, year = {2023}, doi = {10.1038/s41380-022-01890-3}, pmid = {36543923}, url = {https://doi.org/10.1038/s41380-022-01890-3} } @article{li2016-26001840, author = {Li, J. Q. and Tan, L. and Wang, H. F. and Tan, M. S. and Xu, W. and Zhao, Q. F. and Wang, J. and others}, title = {{Risk factors for predicting progression from mild cognitive impairment to Alzheimer's disease: a systematic review and meta-analysis of cohort studies}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2016}, doi = {10.1136/jnnp-2014-310095}, pmid = {26001840}, url = {https://doi.org/10.1136/jnnp-2014-310095} } @article{lill2015-25936935, author = {Lill, C. M. and Rengmark, A. and Pihlstrøm, L. and Fogh, I. and Shatunov, A. and Sleiman, P. M. and Wang, L. S. and Liu, T. and others}, title = {{The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2014.12.009}, pmid = {25936935}, url = {https://doi.org/10.1016/j.jalz.2014.12.009} } @article{pottier2025-40280976, author = {Pottier, Cyril P. and Küçükali, Fahri and Baker, Matt C. and Batzler, Anthony and Jenkins, Gregory D. and van Blitterswijk, Marka and Vicente, Cristina T. and De Coster, Wouter and others}, title = {{Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing}}, journal = {Nature Communications}, year = {2025}, doi = {10.1038/s41467-025-59216-0}, pmid = {40280976}, url = {https://doi.org/10.1038/s41467-025-59216-0} } @article{guo2024-38350061, author = {Guo, C. and Harshfield, E. L. and Markus, H. S.}, title = {{Sleep Characteristics and Risk of Stroke and Dementia: An Observational and Mendelian Randomization Study}}, journal = {Neurology}, year = {2024}, doi = {10.1212/wnl.0000000000209141}, pmid = {38350061}, url = {https://doi.org/10.1212/wnl.0000000000209141} } @article{kauwe2009-18813964, author = {Kauwe, John S K and Wang, Jun and Mayo, Kevin and Morris, John C and Fagan, Anne M and Holtzman, David M and Goate, Alison M}, title = {{Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta}}, journal = {Neurogenetics}, year = {2009}, doi = {10.1007/s10048-008-0150-4}, pmid = {18813964}, url = {https://doi.org/10.1007/s10048-008-0150-4} } @article{zhu2025-41068259, author = {Zhu, Ping and Jin, Zhengxin and Wu, Shiyang and Gao, Shan and He, Yijie and Hu, Shuyuan and Liu, Fengzhen and Chen, Yan and others}, title = {{Genome-wide association study provides insights into the genetic basis of Lewy body dementia}}, journal = {Molecular psychiatry}, year = {2025}, doi = {10.1038/s41380-025-03295-4}, pmid = {41068259}, url = {https://doi.org/10.1038/s41380-025-03295-4} } @article{altmann2014-24623176, author = {Altmann, A. and Tian, L. and Henderson, V. W. and Greicius, M. D. and {Alzheimer's Disease Neuroimaging Initiative Investigators}}, title = {{Sex modifies the APOE-related risk of developing Alzheimer disease}}, journal = {Annals of neurology}, year = {2014}, doi = {10.1002/ana.24135}, pmid = {24623176}, url = {https://doi.org/10.1002/ana.24135} } @article{neu2017-28846757, author = {Neu, S. C. and Pa, J. and Kukull, W. and Beekly, D. and Kuzma, A. and Gangadharan, P. and Wang, L. S. and Romero, K. and others}, title = {{Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.2188}, pmid = {28846757}, url = {https://doi.org/10.1001/jamaneurol.2017.2188} } @article{ferreira2020-32047067, author = {Ferreira, D. and Nordberg, A. and Westman, E.}, title = {{Biological subtypes of Alzheimer disease: A systematic review and meta-analysis}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009058}, pmid = {32047067}, url = {https://doi.org/10.1212/wnl.0000000000009058} } @article{coric2012-22892585, author = {Coric, V. and van Dyck, C. H. and Salloway, S. and Andreasen, N. and Brody, M. and Richter, R. W. and Soininen, H. and Thein, S. and others}, title = {{Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease}}, journal = {Archives of neurology}, year = {2012}, doi = {10.1001/archneurol.2012.2194}, pmid = {22892585}, url = {https://doi.org/10.1001/archneurol.2012.2194} } @article{jonsson2013-23150908, author = {Jonsson, T. and Stefansson, H. and Steinberg, S. and Jonsdottir, I. and Jonsson, P. V. and Snaedal, J. and Bjornsson, S. and Huttenlocher, J. and others}, title = {{Variant of TREM2 associated with the risk of Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2013}, doi = {10.1056/nejmoa1211103}, pmid = {23150908}, url = {https://doi.org/10.1056/nejmoa1211103} } @article{ruiz2014-24041969, author = {Ruiz, A. and Dols-Icardo, O. and Bullido, M. J. and Pastor, P. and Rodríguez-Rodríguez, E. and López de Munain, A. and de Pancorbo, M. M. and Pérez-Tur, J. and others}, title = {{Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia}}, journal = {Neurobiology of aging}, year = {2014}, doi = {10.1016/j.neurobiolaging.2013.08.011}, pmid = {24041969}, url = {https://doi.org/10.1016/j.neurobiolaging.2013.08.011} } @article{rojas2021-33827960, author = {Rojas, J. C. and Wang, P. and Staffaroni, A. M. and Heller, C. and Cobigo, Y. and Wolf, A. and Goh, S. M. and Ljubenkov, P. A. and others}, title = {{Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011848}, pmid = {33827960}, url = {https://doi.org/10.1212/wnl.0000000000011848} } @article{liu2015-24838911, author = {Liu, Y. and Yu, J. T. and Wang, H. F. and Han, P. R. and Tan, C. C. and Wang, C. and Meng, X. F. and Risacher, S. L. and others}, title = {{APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2015}, doi = {10.1136/jnnp-2014-307719}, pmid = {24838911}, url = {https://doi.org/10.1136/jnnp-2014-307719} } @article{serranopozo2021-33340485, author = {Serrano-Pozo, A. and Das, S. and Hyman, B. T.}, title = {{APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches}}, journal = {The Lancet. Neurology}, year = {2021}, doi = {10.1016/s1474-4422(20)30412-9}, pmid = {33340485}, url = {https://doi.org/10.1016/s1474-4422(20)30412-9} } @article{schwartzentruber2021-33589840, author = {Schwartzentruber, J. and Cooper, S. and Liu, J. Z. and Barrio-Hernandez, I. and Bello, E. and Kumasaka, N. and Young, A. M. H. and Franklin, R. J. M. and others}, title = {{Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes}}, journal = {Nature genetics}, year = {2021}, doi = {10.1038/s41588-020-00776-w}, pmid = {33589840}, url = {https://doi.org/10.1038/s41588-020-00776-w} } @article{gold2010-20733306, author = {Gold, M. and Alderton, C. and Zvartau-Hind, M. and Egginton, S. and Saunders, A. M. and Irizarry, M. and Craft, S. and Landreth, G. and others}, title = {{Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study}}, journal = {Dementia and geriatric cognitive disorders}, year = {2010}, doi = {10.1159/000318845}, pmid = {20733306}, url = {https://doi.org/10.1159/000318845} } @article{green2009-19605829, author = {Green, R. C. and Roberts, J. S. and Cupples, L. A. and Relkin, N. R. and Whitehouse, P. J. and Brown, T. and Eckert, S. L. and Butson, M. and others}, title = {{Disclosure of APOE genotype for risk of Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2009}, doi = {10.1056/nejmoa0809578}, pmid = {19605829}, url = {https://doi.org/10.1056/nejmoa0809578} } @article{shannon2023-36915130, author = {Shannon, O. M. and Ranson, J. M. and Gregory, S. and Macpherson, H. and Milte, C. and Lentjes, M. and others}, title = {{Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study}}, journal = {BMC Medicine}, year = {2023}, doi = {10.1186/s12916-023-02772-3}, pmid = {36915130}, url = {https://doi.org/10.1186/s12916-023-02772-3} } @article{leguen2023-36809323, author = {Le Guen, Y. and Raulin, A. C. and Logue, M. W. and Sherva, R. and Belloy, M. E. and Eger, S. J. and Chen, A. and Kennedy, G. and Kuchenbecker, L. and O'Leary, J. P. and Zhang, R. and Merritt, V. C. and others}, title = {{Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease}}, journal = {JAMA}, year = {2023}, doi = {10.1001/jama.2023.0268}, pmid = {36809323}, url = {https://doi.org/10.1001/jama.2023.0268} } @article{mummery2026-41787076, author = {Mummery, C. J. and Mayorga, A. J. and Simmons, A. and Chow, T. W. and Burgess, B. and Nguyen, T. and Gao, J. and Budda, B. and Park, L. Q. and Gupta, R. and Li, C. and Shi, L. and others}, title = {{The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial}}, journal = {Nature Medicine}, year = {2026}, doi = {10.1038/s41591-026-04273-1}, pmid = {41787076}, url = {https://doi.org/10.1038/s41591-026-04273-1} } @article{jansen2022-36066633, author = {Jansen, I. E. and van der Lee, S. J. and Gomez-Fonseca, D. and de Rojas, I. and Dalmasso, M. C. and Grenier-Boley, B. and Zettergren, A. and Mishra, A. and others}, title = {{Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers}}, journal = {Acta neuropathologica}, year = {2022}, doi = {10.1007/s00401-022-02454-z}, pmid = {36066633}, url = {https://doi.org/10.1007/s00401-022-02454-z} } @article{fleisher2008-18195264, author = {Fleisher, A. S. and Sun, S. and Taylor, C. and Ward, C. P. and Gamst, A. C. and Petersen, R. C. and Jack, C. R. and Aisen, P. S. and others}, title = {{Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000287091.57376.65}, pmid = {18195264}, url = {https://doi.org/10.1212/01.wnl.0000287091.57376.65} } @article{woo2025-41451854, author = {Woo, Marcel S and Macedo, Arthur C and Hosseini, Seyyed Ali and Therriault, Joseph and Wang, Yi-Ting and Rahmouni, Nesrine and Aumont, Étienne and Servaes, Stijn and others}, title = {{APOE ɛ4 carriership determines a faster plasma p-tau217 progression in Aβ-positive individuals}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.71048}, pmid = {41451854}, url = {https://doi.org/10.1002/alz.71048} } @article{gonzalez2020-33375167, author = {González, Ricardo D and Gomes, Iva and Gomes, Catarina and Rocha, Rita and Durães, Luís and Sousa, Patrícia and Figueruelo, Manuel and Rodríguez, Maria and others}, title = {{APOE Variants in an Iberian Alzheimer Cohort Detected through an Optimized Sanger Sequencing Protocol}}, journal = {Genes}, year = {2020}, doi = {10.3390/genes12010004}, pmid = {33375167}, url = {https://doi.org/10.3390/genes12010004} } @article{hong2024-39061961, author = {Hong, Eun Pyo and Lim, Seung Hyuk and Youn, Dong Hyuk and Han, Sung Woo and Jung, Harry and Lee, Jae Jun and Jeon, Jin Pyeong and {First Korean Stroke Genetics Association Research The FirstKSGAR Study}}, title = {{Longitudinal Genome-Wide Association Study of Cognitive Impairment after Subarachnoid Hemorrhage}}, journal = {Biomedicines}, year = {2024}, doi = {10.3390/biomedicines12071387}, pmid = {39061961}, url = {https://doi.org/10.3390/biomedicines12071387} } @article{lake2023-37198259, author = {Lake, Julie and Solsberg, Caroline Warly and Kim, Jonggeol Jeffrey and Acosta-Uribe, Juliana and Makarious, Mary B and Li, Zizheng and Levine, Kristin and Heutink, Peter and others}, title = {{Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2023}, doi = {10.1038/s41380-023-02089-w}, pmid = {37198259}, url = {https://doi.org/10.1038/s41380-023-02089-w} } @article{nudelman2023-37801072, author = {Nudelman, Kelly N H and Jackson, Trever and Rumbaugh, Malia and Eloyan, Ani and Abreu, Marco and Dage, Jeffrey L and Snoddy, Casey and Faber, Kelley M and others}, title = {{Pathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.13482}, pmid = {37801072}, url = {https://doi.org/10.1002/alz.13482} } @article{quiroz2024-38899694, author = {Quiroz, Y. T. and Aguillon, D. and Aguirre-Acevedo, D. C. and Vasquez, D. and Zuluaga, Y. and Baena, A. Y. and Madrigal, L. and Hincapié, L. and Sanchez, J. S. and Langella, S. and Posada-Duque, R. and Littau, J. L. and others}, title = {{APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease}}, journal = {New England Journal of Medicine}, year = {2024}, doi = {10.1056/NEJMoa2308583}, pmid = {38899694}, url = {https://doi.org/10.1056/NEJMoa2308583} } @article{bhattarai2024-38598053, author = {Bhattarai, P. and Gunasekaran, T. I. and Belloy, M. E. and Reyes-Dumeyer, D. and Jülich, D. and Tayran, H. and Yilmaz, E. and Flaherty, D. and Turgutalp, B. and Sukumar, G. and Alba, C. and McGrath, E. M. and others}, title = {{Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease}}, journal = {Acta Neuropathologica}, year = {2024}, doi = {10.1007/s00401-024-02721-1}, pmid = {38598053}, url = {https://doi.org/10.1007/s00401-024-02721-1} } @article{salvado2025-40952756, author = {Salvadó, G. and Janelidze, S. and Bali, D. and Dolado, A. O. and Therriault, J. and Brum, W. S. and Pichet Binette, A. and Stomrud, E. and Mattsson-Carlgren, N. and Palmqvist, S. and Coomans, E. M. and Teunissen, C. E. and others}, title = {{Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.3217}, pmid = {40952756}, url = {https://doi.org/10.1001/jamaneurol.2025.3217} } @article{landau2010-20592257, author = {Landau, S. M. and Harvey, D. and Madison, C. M. and Reiman, E. M. and Foster, N. L. and Aisen, P. S. and Petersen, R. C. and Shaw, L. M. and others}, title = {{Comparing predictors of conversion and decline in mild cognitive impairment}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181e8e8b8}, pmid = {20592257}, url = {https://doi.org/10.1212/wnl.0b013e3181e8e8b8} } @article{barbergergateau2007-17998483, author = {Barberger-Gateau, P. and Raffaitin, C. and Letenneur, L. and Berr, C. and Tzourio, C. and Dartigues, J. F. and Alpérovitch, A.}, title = {{Dietary patterns and risk of dementia: the Three-City cohort study}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000278116.37320.52}, pmid = {17998483}, url = {https://doi.org/10.1212/01.wnl.0000278116.37320.52} } @article{chapuis2013-23399914, author = {Chapuis, J. and Hansmannel, F. and Gistelinck, M. and Mounier, A. and Van Cauwenberghe, C. and Kolen, K. V. and Geller, F. and Sottejeau, Y. and others}, title = {{Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology}}, journal = {Molecular psychiatry}, year = {2013}, doi = {10.1038/mp.2013.1}, pmid = {23399914}, url = {https://doi.org/10.1038/mp.2013.1} } @article{naj2014-25199842, author = {Naj, A. C. and Jun, G. and Reitz, C. and Kunkle, B. W. and Perry, W. and Park, Y. S. and Beecham, G. W. and Rajbhandary, R. A. and others}, title = {{Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.1491}, pmid = {25199842}, url = {https://doi.org/10.1001/jamaneurol.2014.1491} } @article{filippi2022-35099507, author = {Filippi, M. and Cecchetti, G. and Spinelli, E. G. and Vezzulli, P. and Falini, A. and Agosta, F.}, title = {{Amyloid-Related Imaging Abnormalities and β-Amyloid-Targeting Antibodies: A Systematic Review}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2021.5205}, pmid = {35099507}, url = {https://doi.org/10.1001/jamaneurol.2021.5205} } @article{fleisher2011-21917762, author = {Fleisher, A. S. and Truran, D. and Mai, J. T. and Langbaum, J. B. and Aisen, P. S. and Cummings, J. L. and Jack, C. R. and Weiner, M. W. and others}, title = {{Chronic divalproex sodium use and brain atrophy in Alzheimer disease}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e318230a16c}, pmid = {21917762}, url = {https://doi.org/10.1212/wnl.0b013e318230a16c} } @article{hampel2020-32296418, author = {Hampel, H. and Caraci, F. and Cuello, A. C. and Caruso, G. and Nisticò, R. and Corbo, M. and Baldacci, F. and Toschi, N. and others}, title = {{A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease}}, journal = {Frontiers in immunology}, year = {2020}, doi = {10.3389/fimmu.2020.00456}, pmid = {32296418}, url = {https://doi.org/10.3389/fimmu.2020.00456} } @article{nelson2014-24770881, author = {Nelson, P. T. and Estus, S. and Abner, E. L. and Parikh, I. and Malik, M. and Neltner, J. H. and Ighodaro, E. and Wang, W. X. and others}, title = {{ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology}}, journal = {Acta neuropathologica}, year = {2014}, doi = {10.1007/s00401-014-1282-2}, pmid = {24770881}, url = {https://doi.org/10.1007/s00401-014-1282-2} } @article{martinezlapiscina2014-24643340, author = {Martínez-Lapiscina, E. H. and Galbete, C. and Corella, D. and Toledo, E. and Buil-Cosiales, P. and Salas-Salvado, J. and Ros, E. and Martinez-Gonzalez, M. A.}, title = {{Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial}}, journal = {Genes \& nutrition}, year = {2014}, doi = {10.1007/s12263-014-0393-7}, pmid = {24643340}, url = {https://doi.org/10.1007/s12263-014-0393-7} } @article{lambert2013-22430674, author = {Lambert, J. C. and Grenier-Boley, B. and Harold, D. and Zelenika, D. and Chouraki, V. and Kamatani, Y. and Sleegers, K. and Ikram, M. A. and others}, title = {{Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2013}, doi = {10.1038/mp.2012.14}, pmid = {22430674}, url = {https://doi.org/10.1038/mp.2012.14} } @article{risner2006-16446752, author = {Risner, M. E. and Saunders, A. M. and Altman, J. F. and Ormandy, G. C. and Craft, S. and Foley, I. M. and Zvartau-Hind, M. E. and Hosford, D. A. and others}, title = {{Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease}}, journal = {The pharmacogenomics journal}, year = {2006}, doi = {10.1038/sj.tpj.6500369}, pmid = {16446752}, url = {https://doi.org/10.1038/sj.tpj.6500369} } @article{derojas2021-34099642, author = {de Rojas, I. and Moreno-Grau, S. and Tesi, N. and Grenier-Boley, B. and Andrade, V. and Jansen, I. E. and Pedersen, N. L. and Stringa, N. and others}, title = {{Common variants in Alzheimer's disease and risk stratification by polygenic risk scores}}, journal = {Nature communications}, year = {2021}, doi = {10.1038/s41467-021-22491-8}, pmid = {34099642}, url = {https://doi.org/10.1038/s41467-021-22491-8} } @article{grarup2013-23754956, author = {Grarup, N. and Sulem, P. and Sandholt, C. H. and Thorleifsson, G. and Ahluwalia, T. S. and Steinthorsdottir, V. and Bjarnason, H. and Gudbjartsson, D. F. and others}, title = {{Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets}}, journal = {PLoS genetics}, year = {2013}, doi = {10.1371/journal.pgen.1003530}, pmid = {23754956}, url = {https://doi.org/10.1371/journal.pgen.1003530} } @article{yang2026-f71c1569, author = {Yang, S. and Grilli, M. D. and Wootton, R. E. and van de Weijer, M. P. and Treur, J. L. and Klimentidis, Y. C. and Sbarra, D. A.}, title = {{Loneliness as a Pathway Linking Hearing Decline to Cognitive Aging: Longitudinal and Genetic Evidence}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.64898/2026.04.16.26351059}, url = {https://doi.org/10.64898/2026.04.16.26351059} } @article{perna2023-37951931, author = {Perna, L. and Stocker, H. and Burow, L. and Beyer, L. and Trares, K. and Kurz, C. and Gürsel, S. and Holleczek, B. and others}, title = {{Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study}}, journal = {Alzheimer's research \& therapy}, year = {2023}, doi = {10.1186/s13195-023-01341-3}, pmid = {37951931}, url = {https://doi.org/10.1186/s13195-023-01341-3} } @article{hohman2018-29801024, author = {Hohman, T. J. and Dumitrescu, L. and Barnes, L. L. and Thambisetty, M. and Beecham, G. and Kunkle, B. and Gifford, K. A. and Bush, W. S. and others}, title = {{Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2018.0821}, pmid = {29801024}, url = {https://doi.org/10.1001/jamaneurol.2018.0821} } @article{kern2018-29653987, author = {Kern, S. and Zetterberg, H. and Kern, J. and Zettergren, A. and Waern, M. and Höglund, K. and Andreasson, U. and Wetterberg, H. and others}, title = {{Prevalence of preclinical Alzheimer disease: Comparison of current classification systems}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005476}, pmid = {29653987}, url = {https://doi.org/10.1212/wnl.0000000000005476} } @article{nalls2013-23588557, author = {Nalls, M. A. and Duran, R. and Lopez, G. and Kurzawa-Akanbi, M. and McKeith, I. G. and Chinnery, P. F. and Morris, C. M. and Theuns, J. and others}, title = {{A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.1925}, pmid = {23588557}, url = {https://doi.org/10.1001/jamaneurol.2013.1925} } @article{mukamal2003-12636463, author = {Mukamal, K. J. and Kuller, L. H. and Fitzpatrick, A. L. and Longstreth, W. T. and Mittleman, M. A. and Siscovick, D. S.}, title = {{Prospective study of alcohol consumption and risk of dementia in older adults}}, journal = {JAMA}, year = {2003}, doi = {10.1001/jama.289.11.1405}, pmid = {12636463}, url = {https://doi.org/10.1001/jama.289.11.1405} } @article{morenasrodriguez2022-35305339, author = {Morenas-Rodríguez, E. and Li, Y. and Nuscher, B. and Franzmeier, N. and Xiong, C. and Suárez-Calvet, M. and Fagan, A. M. and Schultz, S. and others}, title = {{Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study}}, journal = {The Lancet. Neurology}, year = {2022}, doi = {10.1016/s1474-4422(22)00027-8}, pmid = {35305339}, url = {https://doi.org/10.1016/s1474-4422(22)00027-8} } @article{johnson2018-29322089, author = {Johnson, S. C. and Koscik, R. L. and Jonaitis, E. M. and Clark, L. R. and Mueller, K. D. and Berman, S. E. and Bendlin, B. B. and Engelman, C. D. and others}, title = {{The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2018}, doi = {10.1016/j.dadm.2017.11.007}, pmid = {29322089}, url = {https://doi.org/10.1016/j.dadm.2017.11.007} } @article{parhizkar2019-30617257, author = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others}, title = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-018-0296-9}, pmid = {30617257}, url = {https://doi.org/10.1038/s41593-018-0296-9} } @article{long2024-39444037, author = {Long, H. and Simmons, A. and Mayorga, A. and Burgess, B. and Nguyen, T. and Budda, B. and Rychkova, A. and Rhinn, H. and others}, title = {{Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01599-1}, pmid = {39444037}, url = {https://doi.org/10.1186/s13195-024-01599-1} } @article{armstrong2020-32517579, author = {Armstrong, N. J. and Mather, K. A. and Sargurupremraj, M. and Knol, M. J. and Malik, R. and Satizabal, C. L. and Yanek, L. R. and Wen, W. and others}, title = {{Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities}}, journal = {Stroke}, year = {2020}, doi = {10.1161/strokeaha.119.027544}, pmid = {32517579}, url = {https://doi.org/10.1161/strokeaha.119.027544} } @article{wolters2019-31356640, author = {Wolters, F. J. and Yang, Q. and Biggs, M. L. and Jakobsdottir, J. and Li, S. and Evans, D. S. and Bis, J. C. and Harris, T. B. and others}, title = {{The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)}}, journal = {PloS one}, year = {2019}, doi = {10.1371/journal.pone.0219668}, pmid = {31356640}, url = {https://doi.org/10.1371/journal.pone.0219668} } @article{roostaei2017-27021820, author = {Roostaei, T. and Nazeri, A. and Felsky, D. and De Jager, P. L. and Schneider, J. A. and Pollock, B. G. and Bennett, D. A. and Voineskos, A. N. and others}, title = {{Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2017}, doi = {10.1038/mp.2016.35}, pmid = {27021820}, url = {https://doi.org/10.1038/mp.2016.35} } @article{sevigny2024-38745011, author = {Sevigny, J. and Uspenskaya, O. and Heckman, L. D. and Wong, L. C. and Hatch, D. A. and Tewari, A. and Vandenberghe, R. and Irwin, D. J. and others}, title = {{Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-02973-0}, pmid = {38745011}, url = {https://doi.org/10.1038/s41591-024-02973-0} } @article{broce2018-29315334, author = {Broce, I. and Karch, C. M. and Wen, N. and Fan, C. C. and Wang, Y. and Tan, C. H. and Kouri, N. and Ross, O. A. and others}, title = {{Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies}}, journal = {PLoS medicine}, year = {2018}, doi = {10.1371/journal.pmed.1002487}, pmid = {29315334}, url = {https://doi.org/10.1371/journal.pmed.1002487} } @article{mentis2021-33435977, author = {Mentis, A. A. and Dardiotis, E. and Efthymiou, V. and Chrousos, G. P.}, title = {{Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews}}, journal = {BMC medicine}, year = {2021}, doi = {10.1186/s12916-020-01873-7}, pmid = {33435977}, url = {https://doi.org/10.1186/s12916-020-01873-7} } @article{cramer2008-18663180, author = {Cramer, C. and Haan, M. N. and Galea, S. and Langa, K. M. and Kalbfleisch, J. D.}, title = {{Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000319647.15752.7b}, pmid = {18663180}, url = {https://doi.org/10.1212/01.wnl.0000319647.15752.7b} } @article{stevensonhoare2023-35383826, author = {Stevenson-Hoare, J. and Heslegrave, A. and Leonenko, G. and Fathalla, D. and Bellou, E. and Luckcuck, L. and Marshall, R. and Sims, R. and others}, title = {{Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2023}, doi = {10.1093/brain/awac128}, pmid = {35383826}, url = {https://doi.org/10.1093/brain/awac128} } @article{oconnor2021-32665603, author = {O'Connor, A. and Karikari, T. K. and Poole, T. and Ashton, N. J. and Lantero Rodriguez, J. and Khatun, A. and Swift, I. and Heslegrave, A. J. and others}, title = {{Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort study}}, journal = {Molecular psychiatry}, year = {2021}, doi = {10.1038/s41380-020-0838-x}, pmid = {32665603}, url = {https://doi.org/10.1038/s41380-020-0838-x} } @article{johansson2023-36626935, author = {Johansson, C. and Thordardottir, S. and Laffita-Mesa, J. and Rodriguez-Vieitez, E. and Zetterberg, H. and Blennow, K. and Graff, C.}, title = {{Plasma biomarker profiles in autosomal dominant Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2023}, doi = {10.1093/brain/awac399}, pmid = {36626935}, url = {https://doi.org/10.1093/brain/awac399} } @article{deming2017-28247064, author = {Deming, Y. and Li, Z. and Kapoor, M. and Harari, O. and Del-Aguila, J. L. and Black, K. and Carrell, D. and Cai, Y. and others}, title = {{Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers}}, journal = {Acta neuropathologica}, year = {2017}, doi = {10.1007/s00401-017-1685-y}, pmid = {28247064}, url = {https://doi.org/10.1007/s00401-017-1685-y} } @article{dumitrescu2020-32844198, author = {Dumitrescu, L. and Mahoney, E. R. and Mukherjee, S. and Lee, M. L. and Bush, W. S. and Engelman, C. D. and Lu, Q. and Fardo, D. W. and others}, title = {{Genetic variants and functional pathways associated with resilience to Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2020}, doi = {10.1093/brain/awaa209}, pmid = {32844198}, url = {https://doi.org/10.1093/brain/awaa209} } @article{knopman2023-37295957, author = {Knopman, D. S. and Hershey, L.}, title = {{Implications of the Approval of Lecanemab for Alzheimer Disease Patient Care: Incremental Step or Paradigm Shift?}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207438}, pmid = {37295957}, url = {https://doi.org/10.1212/wnl.0000000000207438} } @article{xu2025-41307156, author = {Xu, Yuexuan and Qiao, Min and Gunasekaran, Tamil I and Gu, Yian and Reyes-Dumeyer, Dolly and Piriz, Angel and Sanchez, Danurys and Soriano, Belisa and others}, title = {{Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70937}, pmid = {41307156}, url = {https://doi.org/10.1002/alz.70937} } @article{zhou2020-32775599, author = {Zhou, Xiaopu and Chen, Yu and Ip, Fanny C F and Lai, Nicole C H and Li, Yolanda Y T and Jiang, Yuanbing and Zhong, Huan and Chen, Yuewen and others}, title = {{Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2020}, doi = {10.1002/dad2.12074}, pmid = {32775599}, url = {https://doi.org/10.1002/dad2.12074} } @article{tessier2024-38709531, author = {Tessier, A. J. and Cortese, M. and Yuan, C. and Bjornevik, K. and Ascherio, A. and Wang, D. D. and Chavarro, J. E. and Stampfer, M. J. and Hu, F. B. and Willett, W. C. and others}, title = {{Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death}}, journal = {JAMA Network Open}, year = {2024}, doi = {10.1001/jamanetworkopen.2024.10021}, pmid = {38709531}, url = {https://doi.org/10.1001/jamanetworkopen.2024.10021} } @article{sanchez2025-40063856, author = {Sanchez, E. and Coughlan, G. T. and Wilkinson, T. and Ramirez, J. and Mirza, S. S. and Baril, A. A. and Dilliott, A. A. and Frank, A. and others}, title = {{Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213438}, pmid = {40063856}, url = {https://doi.org/10.1212/wnl.0000000000213438} } @article{farrer1997-9343467, author = {Farrer, L. A. and Cupples, L. A. and Haines, J. L. and Hyman, B. and Kukull, W. A. and Mayeux, R. and Myers, R. H. and Pericak-Vance, M. A. and others}, title = {{Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium}}, journal = {JAMA}, year = {1997}, doi = {10.1001/jama.1997.03550160069041}, pmid = {9343467}, url = {https://doi.org/10.1001/jama.1997.03550160069041} } @article{tang1998-9508150, author = {Tang, M. X. and Stern, Y. and Marder, K. and Bell, K. and Gurland, B. and Lantigua, R. and Andrews, H. and Feng, L. and others}, title = {{The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics}}, journal = {JAMA}, year = {1998}, doi = {10.1001/jama.279.10.751}, pmid = {9508150}, url = {https://doi.org/10.1001/jama.279.10.751} } @article{sargurupremraj2020-33293549, author = {Sargurupremraj, M. and Suzuki, H. and Jian, X. and Sarnowski, C. and Evans, T. E. and Bis, J. C. and Eiriksdottir, G. and Sakaue, S. and others}, title = {{Cerebral small vessel disease genomics and its implications across the lifespan}}, journal = {Nature communications}, year = {2020}, doi = {10.1038/s41467-020-19111-2}, pmid = {33293549}, url = {https://doi.org/10.1038/s41467-020-19111-2} } @article{hithersay2019-30452522, author = {Hithersay, R. and Startin, C. M. and Hamburg, S. and Mok, K. Y. and Hardy, J. and Fisher, E. M. C. and Tybulewicz, V. L. J. and Nizetic, D. and others}, title = {{Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2018.3616}, pmid = {30452522}, url = {https://doi.org/10.1001/jamaneurol.2018.3616} } @article{salinas2022-35131906, author = {Salinas, J. and Beiser, A. S. and Samra, J. K. and O'Donnell, A. and DeCarli, C. S. and Gonzales, M. M. and Aparicio, H. J. and Seshadri, S.}, title = {{Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200039}, pmid = {35131906}, url = {https://doi.org/10.1212/wnl.0000000000200039} } @article{ritchie2010-20688841, author = {Ritchie, K. and Carrière, I. and Ritchie, C. W. and Berr, C. and Artero, S. and Ancelin, M. L.}, title = {{Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors}}, journal = {BMJ (Clinical research ed.)}, year = {2010}, doi = {10.1136/bmj.c3885}, pmid = {20688841}, url = {https://doi.org/10.1136/bmj.c3885} } @article{wilson2002-11851541, author = {Wilson, R. S. and Mendes De Leon, C. F. and Barnes, L. L. and Schneider, J. A. and Bienias, J. L. and Evans, D. A. and Bennett, D. A.}, title = {{Participation in cognitively stimulating activities and risk of incident Alzheimer disease}}, journal = {JAMA}, year = {2002}, doi = {10.1001/jama.287.6.742}, pmid = {11851541}, url = {https://doi.org/10.1001/jama.287.6.742} } @article{mirza2019-31575706, author = {Mirza, S. S. and Saeed, U. and Knight, J. and Ramirez, J. and Stuss, D. T. and Keith, J. and Nestor, S. M. and Yu, D. and others}, title = {{APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia}}, journal = {Neurology}, year = {2019}, doi = {10.1212/wnl.0000000000008377}, pmid = {31575706}, url = {https://doi.org/10.1212/wnl.0000000000008377} } @article{marden2014-25328845, author = {Marden, JR. and Walter, S. and Tchetgen Tchetgen, E. J. and Kawachi, I. and Glymour, M. M.}, title = {{Validation of a polygenic risk score for dementia in black and white individuals}}, journal = {Brain and behavior}, year = {2014}, doi = {10.1002/brb3.248}, pmid = {25328845}, url = {https://doi.org/10.1002/brb3.248} } @article{szwedo2022-35106798, author = {Szwedo, A. A. and Dalen, I. and Pedersen, K. F. and Camacho, M. and Bäckström, D. and Forsgren, L. and Tzoulis, C. and Winder-Rhodes, S. and others}, title = {{GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2022}, doi = {10.1002/mds.28932}, pmid = {35106798}, url = {https://doi.org/10.1002/mds.28932} } @article{vanderlee2018-29555425, author = {van der Lee, S. J. and Wolters, F. J. and Ikram, M. K. and Hofman, A. and Ikram, M. A. and Amin, N. and van Duijn, C. M.}, title = {{The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(18)30053-x}, pmid = {29555425}, url = {https://doi.org/10.1016/s1474-4422(18)30053-x} } @article{caselli2009-19605830, author = {Caselli, R. J. and Dueck, A. C. and Osborne, D. and Sabbagh, M. N. and Connor, D. J. and Ahern, G. L. and Baxter, L. C. and Rapcsak, S. Z. and others}, title = {{Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect}}, journal = {The New England journal of medicine}, year = {2009}, doi = {10.1056/nejmoa0809437}, pmid = {19605830}, url = {https://doi.org/10.1056/nejmoa0809437} } @article{rikos2024-36408688, author = {Rikos, D. and Siokas, V. and Mentis, A. A. and Aloizou, A. M. and Liampas, I. and Tsouris, Z. and Peristeri, E. and Stamati, P. and others}, title = {{TREM2 R47H variant and risk for Alzheimer's disease: assessment in a Greek population and updated meta-analysis}}, journal = {The International journal of neuroscience}, year = {2024}, doi = {10.1080/00207454.2022.2150844}, pmid = {36408688}, url = {https://doi.org/10.1080/00207454.2022.2150844} } @article{belder2026-42637536, author = {Belder, Christopher R S and Heslegrave, Amanda J and Swann, Owen and Abel, Emily and Beament, Millie and Nasir, Moneeb and Rice, Helen and Weston, Philip S J and others}, title = {{Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2026}, doi = {10.1136/jnnp-2026-339037}, pmid = {42637536}, url = {https://doi.org/10.1136/jnnp-2026-339037} } @article{zhou2023-37042462, author = {Zhou, Robin Ziyue and Vetrano, Davide Liborio and Grande, Giulia and Duell, Frida and Jönsson, Linus and Laukka, Erika J and Fredolini, Claudia and Winblad, Bengt and others}, title = {{A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.13024}, pmid = {37042462}, url = {https://doi.org/10.1002/alz.13024} } @article{pan2024-39523637, author = {Pan, Minmin and Lai, Dongbing and Unverzagt, Frederick and Apostolova, Liana and Hendrie, Hugh C and Saykin, Andrew and Foroud, Tatiana and Gao, Sujuan}, title = {{Genetic variants for Alzheimer's disease and comorbid conditions}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2024}, doi = {10.1177/13872877241289054}, pmid = {39523637}, url = {https://doi.org/10.1177/13872877241289054} } @article{vialle2025-40038788, author = {Vialle, Ricardo A and Lopes, Katia de Paiva and Li, Yan and Ng, Bernard and Schneider, Julie A and Buchman, Aron S and Wang, Yanling and Farfel, Jose M and others}, title = {{Structural variants linked to Alzheimer's disease and other common age-related clinical and neuropathologic traits}}, journal = {Genome medicine}, year = {2025}, doi = {10.1186/s13073-025-01444-6}, pmid = {40038788}, url = {https://doi.org/10.1186/s13073-025-01444-6} } @article{ajnakina2020-32187654, author = {Ajnakina, Olesya and Cadar, Dorina and Steptoe, Andrew}, title = {{Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis}}, journal = {Journal of the American Geriatrics Society}, year = {2020}, doi = {10.1111/jgs.16406}, pmid = {32187654}, url = {https://doi.org/10.1111/jgs.16406} } @article{nabizadeh2024-38961148, author = {Nabizadeh, Fardin and Seyedmirzaei, Homa and Karami, Shaghayegh}, title = {{Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study}}, journal = {Scientific reports}, year = {2024}, doi = {10.1038/s41598-024-66211-w}, pmid = {38961148}, url = {https://doi.org/10.1038/s41598-024-66211-w} } @article{jang2022-36440278, author = {Jang, Ha Young and Oh, Jung Mi and Kim, In-Wha}, title = {{Drug repurposing using meta-analysis of gene expression in Alzheimer's disease}}, journal = {Frontiers in neuroscience}, year = {2022}, doi = {10.3389/fnins.2022.989174}, pmid = {36440278}, url = {https://doi.org/10.3389/fnins.2022.989174} } @article{zhang2023-36269005, author = {Zhang, Zilong and Chen, Lan and Wang, Xiaojie and Wang, Chongjian and Yang, Yin and Li, Haitao and Cai, Miao and Lin, Hualiang}, title = {{Associations of Air Pollution and Genetic Risk With Incident Dementia: A Prospective Cohort Study}}, journal = {American journal of epidemiology}, year = {2023}, doi = {10.1093/aje/kwac188}, pmid = {36269005}, url = {https://doi.org/10.1093/aje/kwac188} } @article{jabbari2020-31860007, author = {Jabbari, E. and Holland, N. and Chelban, V. and Jones, P. S. and Lamb, R. and Rawlinson, C. and Guo, T. and Costantini, A. A. and others}, title = {{Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2019.4347}, pmid = {31860007}, url = {https://doi.org/10.1001/jamaneurol.2019.4347} } @article{luchsinger2007-17420320, author = {Luchsinger, J. A. and Reitz, C. and Patel, B. and Tang, M. X. and Manly, J. J. and Mayeux, R.}, title = {{Relation of diabetes to mild cognitive impairment}}, journal = {Archives of neurology}, year = {2007}, doi = {10.1001/archneur.64.4.570}, pmid = {17420320}, url = {https://doi.org/10.1001/archneur.64.4.570} } @article{roberts2016-26569387, author = {Roberts, R. O. and Christianson, T. J. and Kremers, W. K. and Mielke, M. M. and Machulda, M. M. and Vassilaki, M. and Alhurani, R. E. and Geda, Y. E. and others}, title = {{Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2015.2952}, pmid = {26569387}, url = {https://doi.org/10.1001/jamaneurol.2015.2952} } @article{tsuang2013-23407718, author = {Tsuang, D. and Leverenz, J. B. and Lopez, O. L. and Hamilton, R. L. and Bennett, D. A. and Schneider, J. A. and Buchman, A. S. and Larson, E. B. and others}, title = {{APOE ε4 increases risk for dementia in pure synucleinopathies}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.600}, pmid = {23407718}, url = {https://doi.org/10.1001/jamaneurol.2013.600} } @article{piccio2016-26754641, author = {Piccio, L. and Deming, Y. and Del-Águila, J. L. and Ghezzi, L. and Holtzman, D. M. and Fagan, A. M. and Fenoglio, C. and Galimberti, D. and others}, title = {{Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-016-1533-5}, pmid = {26754641}, url = {https://doi.org/10.1007/s00401-016-1533-5} } @article{slooter1998-9678314, author = {Slooter, A. J. and Cruts, M. and Kalmijn, S. and Hofman, A. and Breteler, M. M. and Van Broeckhoven, C. and van Duijn, C. M.}, title = {{Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study}}, journal = {Archives of neurology}, year = {1998}, doi = {10.1001/archneur.55.7.964}, pmid = {9678314}, url = {https://doi.org/10.1001/archneur.55.7.964} } @article{miyashita2013-23565137, author = {Miyashita, A. and Koike, A. and Jun, G. and Wang, L. S. and Takahashi, S. and Matsubara, E. and Kawarabayashi, T. and Shoji, M. and others}, title = {{SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians}}, journal = {PloS one}, year = {2013}, doi = {10.1371/journal.pone.0058618}, pmid = {23565137}, url = {https://doi.org/10.1371/journal.pone.0058618} } @article{verhaaren2015-25663218, author = {Verhaaren, B. F. and Debette, S. and Bis, J. C. and Smith, J. A. and Ikram, M. K. and Adams, H. H. and Beecham, A. H. and Rajan, K. B. and others}, title = {{Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI}}, journal = {Circulation. Cardiovascular genetics}, year = {2015}, doi = {10.1161/circgenetics.114.000858}, pmid = {25663218}, url = {https://doi.org/10.1161/circgenetics.114.000858} } @article{chauhan2015-25670335, author = {Chauhan, G. and Adams, H. H. H. and Bis, J. C. and Weinstein, G. and Yu, L. and Töglhofer, A. M. and Smith, A. V. and van der Lee, S. J. and others}, title = {{Association of Alzheimer's disease GWAS loci with MRI markers of brain aging}}, journal = {Neurobiology of aging}, year = {2015}, doi = {10.1016/j.neurobiolaging.2014.12.028}, pmid = {25670335}, url = {https://doi.org/10.1016/j.neurobiolaging.2014.12.028} } @article{farnsworthvoncederwald2022-35444051, author = {Farnsworth von Cederwald, B. and Josefsson, M. and Wåhlin, A. and Nyberg, L. and Karalija, N.}, title = {{Association of Cardiovascular Risk Trajectory With Cognitive Decline and Incident Dementia}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200255}, pmid = {35444051}, url = {https://doi.org/10.1212/wnl.0000000000200255} } @article{christensen2018-28726810, author = {Christensen, K. D. and Uhlmann, W. R. and Roberts, J. S. and Linnenbringer, E. and Whitehouse, P. J. and Royal, C. D. M. and Obisesan, T. O. and Cupples, L. A. and others}, title = {{A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone}}, journal = {Genetics in medicine : official journal of the American College of Medical Genetics}, year = {2018}, doi = {10.1038/gim.2017.103}, pmid = {28726810}, url = {https://doi.org/10.1038/gim.2017.103} } @article{reines2004-14718699, author = {Reines, S. A. and Block, G. A. and Morris, J. C. and Liu, G. and Nessly, M. L. and Lines, C. R. and Norman, B. A. and Baranak, C. C. and others}, title = {{Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study}}, journal = {Neurology}, year = {2004}, doi = {10.1212/wnl.62.1.66}, pmid = {14718699}, url = {https://doi.org/10.1212/wnl.62.1.66} } @article{gottesman2016-27371485, author = {Gottesman, R. F. and Schneider, A. L. and Zhou, Y. and Chen, X. and Green, E. and Gupta, N. and Knopman, D. S. and Mintz, A. and others}, title = {{The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000002914}, pmid = {27371485}, url = {https://doi.org/10.1212/wnl.0000000000002914} } @article{fortea2024-38710950, author = {Fortea, J. and Pegueroles, J. and Alcolea, D. and Belbin, O. and Dols-Icardo, O. and Vaqué-Alcázar, L. and Videla, L. and Gispert, J. D. and others}, title = {{APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-02931-w}, pmid = {38710950}, url = {https://doi.org/10.1038/s41591-024-02931-w} } @article{mccarty2011-21269473, author = {McCarty, C. A. and Chisholm, R. L. and Chute, C. G. and Kullo, I. J. and Jarvik, G. P. and Larson, E. B. and Li, R. and Masys, D. R. and others}, title = {{The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies}}, journal = {BMC medical genomics}, year = {2011}, doi = {10.1186/1755-8794-4-13}, pmid = {21269473}, url = {https://doi.org/10.1186/1755-8794-4-13} } @article{petersen2005-15829527, author = {Petersen, R. C. and Thomas, R. G. and Grundman, M. and Bennett, D. and Doody, R. and Ferris, S. and Galasko, D. and Jin, S. and others}, title = {{Vitamin E and donepezil for the treatment of mild cognitive impairment}}, journal = {The New England journal of medicine}, year = {2005}, doi = {10.1056/nejmoa050151}, pmid = {15829527}, url = {https://doi.org/10.1056/nejmoa050151} } @article{suarezcalvet2019-30630532, author = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others}, title = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-018-0301-5}, pmid = {30630532}, url = {https://doi.org/10.1186/s13024-018-0301-5} } @article{benitez2014-24439484, author = {Benitez, B. A. and Jin, S. C. and Guerreiro, R. and Graham, R. and Lord, J. and Harold, D. and Sims, R. and Lambert, J. C. and others}, title = {{Missense variant in TREML2 protects against Alzheimer's disease}}, journal = {Neurobiology of aging}, year = {2014}, doi = {10.1016/j.neurobiolaging.2013.12.010}, pmid = {24439484}, url = {https://doi.org/10.1016/j.neurobiolaging.2013.12.010} } @article{benitez2013-23990795, author = {Benitez, B. A. and Karch, C. M. and Cai, Y. and Jin, S. C. and Cooper, B. and Carrell, D. and Bertelsen, S. and Chibnik, L. and others}, title = {{The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers}}, journal = {PLoS genetics}, year = {2013}, doi = {10.1371/journal.pgen.1003685}, pmid = {23990795}, url = {https://doi.org/10.1371/journal.pgen.1003685} } @article{zou2012-22685416, author = {Zou, F. and Chai, H. S. and Younkin, C. S. and Allen, M. and Crook, J. and Pankratz, V. S. and Carrasquillo, M. M. and Rowley, C. N. and others}, title = {{Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants}}, journal = {PLoS genetics}, year = {2012}, doi = {10.1371/journal.pgen.1002707}, pmid = {22685416}, url = {https://doi.org/10.1371/journal.pgen.1002707} } @article{grupe2007-17317784, author = {Grupe, A. and Abraham, R. and Li, Y. and Rowland, C. and Hollingworth, P. and Morgan, A. and Jehu, L. and Segurado, R. and others}, title = {{Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants}}, journal = {Human molecular genetics}, year = {2007}, doi = {10.1093/hmg/ddm031}, pmid = {17317784}, url = {https://doi.org/10.1093/hmg/ddm031} } @article{rietveld2014-25201988, author = {Rietveld, C. A. and Esko, T. and Davies, G. and Pers, T. H. and Turley, P. and Benyamin, B. and Chabris, C. F. and Emilsson, V. and others}, title = {{Common genetic variants associated with cognitive performance identified using the proxy-phenotype method}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2014}, doi = {10.1073/pnas.1404623111}, pmid = {25201988}, url = {https://doi.org/10.1073/pnas.1404623111} } @article{power2017-27519822, author = {Power, R. A. and Tansey, K. E. and Buttenschøn, H. N. and Cohen-Woods, S. and Bigdeli, T. and Hall, L. S. and Kutalik, Z. and Lee, S. H. and others}, title = {{Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium}}, journal = {Biological psychiatry}, year = {2017}, doi = {10.1016/j.biopsych.2016.05.010}, pmid = {27519822}, url = {https://doi.org/10.1016/j.biopsych.2016.05.010} } @article{vergallo2019-31113759, author = {Vergallo, A. and Mégret, L. and Lista, S. and Cavedo, E. and Zetterberg, H. and Blennow, K. and Vanmechelen, E. and De Vos, A. and others}, title = {{Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.03.009}, pmid = {31113759}, url = {https://doi.org/10.1016/j.jalz.2019.03.009} } @article{hwang2025-41388319, author = {Hwang, Jiyun and Moon, So Young and Lee, Harim and Lee, Jaejin and Park, Yoo Kyoung and Jeong, Jee Hyang and Hong, Chang Hyung and Jung, Jiwoo and others}, title = {{Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-025-01907-3}, pmid = {41388319}, url = {https://doi.org/10.1186/s13195-025-01907-3} } @article{topiwala2026-40987604, author = {Topiwala, A. and Levey, D. F. and Zhou, H. and Deak, J. D. and Adhikari, K. and Ebmeier, K. P. and others}, title = {{Alcohol use and risk of dementia in diverse populations: evidence from cohort, case-control and Mendelian randomisation approaches}}, journal = {BMJ Evidence-Based Medicine}, year = {2026}, doi = {10.1136/bmjebm-2025-113913}, pmid = {40987604}, url = {https://doi.org/10.1136/bmjebm-2025-113913} } @article{sperling2020-32250387, author = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Sun, C. K. and Yaari, R. and Holdridge, K. and Siemers, E. and Johnson, K. A. and others}, title = {{Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.0387}, pmid = {32250387}, url = {https://doi.org/10.1001/jamaneurol.2020.0387} } @article{therriault2021-33443136, author = {Therriault, J. and Pascoal, T. A. and Benedet, A. L. and Tissot, C. and Savard, M. and Chamoun, M. and Lussier, F. and Kang, M. S. and others}, title = {{Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011416}, pmid = {33443136}, url = {https://doi.org/10.1212/wnl.0000000000011416} } @article{yu2015-25365775, author = {Yu, L. and Chibnik, L. B. and Srivastava, G. P. and Pochet, N. and Yang, J. and Xu, J. and Kozubek, J. and Obholzer, N. and others}, title = {{Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2014.3049}, pmid = {25365775}, url = {https://doi.org/10.1001/jamaneurol.2014.3049} } @article{ganguli2000-10867779, author = {Ganguli, M. and Chandra, V. and Kamboh, M. I. and Johnston, J. M. and Dodge, H. H. and Thelma, B. K. and Juyal, R. C. and Pandav, R. and others}, title = {{Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study}}, journal = {Archives of neurology}, year = {2000}, doi = {10.1001/archneur.57.6.824}, pmid = {10867779}, url = {https://doi.org/10.1001/archneur.57.6.824} } @article{szekely2008-18003940, author = {Szekely, C. A. and Breitner, J. C. and Fitzpatrick, A. L. and Rea, T. D. and Psaty, B. M. and Kuller, L. H. and Zandi, P. P.}, title = {{NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000284596.95156.48}, pmid = {18003940}, url = {https://doi.org/10.1212/01.wnl.0000284596.95156.48} } @article{bernath2020-32358220, author = {Bernath, M. M. and Bhattacharyya, S. and Nho, K. and Barupal, D. K. and Fiehn, O. and Baillie, R. and Risacher, S. L. and Arnold, M. and others}, title = {{Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009436}, pmid = {32358220}, url = {https://doi.org/10.1212/wnl.0000000000009436} } @article{bettens2012-22248099, author = {Bettens, K. and Brouwers, N. and Engelborghs, S. and Lambert, J. C. and Rogaeva, E. and Vandenberghe, R. and Le Bastard, N. and Pasquier, F. and others}, title = {{Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk}}, journal = {Molecular neurodegeneration}, year = {2012}, doi = {10.1186/1750-1326-7-3}, pmid = {22248099}, url = {https://doi.org/10.1186/1750-1326-7-3} } @article{petersen1995-7646655, author = {Petersen, R. C. and Smith, G. E. and Ivnik, R. J. and Tangalos, E. G. and Schaid, D. J. and Thibodeau, S. N. and Kokmen, E. and Waring, S. C. and others}, title = {{Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals}}, journal = {JAMA}, year = {1995}, doi = {10.1001/jama.1995.03520400044042}, pmid = {7646655}, url = {https://doi.org/10.1001/jama.1995.03520400044042} } @article{irwin2017-27979356, author = {Irwin, D. J. and Grossman, M. and Weintraub, D. and Hurtig, H. I. and Duda, J. E. and Xie, S. X. and Lee, E. B. and Van Deerlin, V. M. and others}, title = {{Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis}}, journal = {The Lancet. Neurology}, year = {2017}, doi = {10.1016/s1474-4422(16)30291-5}, pmid = {27979356}, url = {https://doi.org/10.1016/s1474-4422(16)30291-5} } @article{holstege2022-36411364, author = {Holstege, H. and Hulsman, M. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Grozeva, D. and van Rooij, J. G. J. and Sims, R. and others}, title = {{Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease}}, journal = {Nature genetics}, year = {2022}, doi = {10.1038/s41588-022-01208-7}, pmid = {36411364}, url = {https://doi.org/10.1038/s41588-022-01208-7} } @article{hughes2013-24132374, author = {Hughes, T. M. and Kuller, L. H. and Barinas-Mitchell, E. J. and Mackey, R. H. and McDade, E. M. and Klunk, W. E. and Aizenstein, H. J. and Cohen, A. D. and others}, title = {{Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults}}, journal = {Neurology}, year = {2013}, doi = {10.1212/01.wnl.0000435301.64776.37}, pmid = {24132374}, url = {https://doi.org/10.1212/01.wnl.0000435301.64776.37} } @article{ayton2015-25988319, author = {Ayton, S. and Faux, N. G. and Bush, A. I. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE}}, journal = {Nature communications}, year = {2015}, doi = {10.1038/ncomms7760}, pmid = {25988319}, url = {https://doi.org/10.1038/ncomms7760} } @article{carrasquillo2017-27939925, author = {Carrasquillo, M. M. and Allen, M. and Burgess, J. D. and Wang, X. and Strickland, S. L. and Aryal, S. and Siuda, J. and Kachadoorian, M. L. and others}, title = {{A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.10.005}, pmid = {27939925}, url = {https://doi.org/10.1016/j.jalz.2016.10.005} } @article{klee2023-37085245, author = {Klee, M. and Leist, A. K. and Veldsman, M. and Ranson, J. M. and Llewellyn, D. J.}, title = {{Socioeconomic Deprivation, Genetic Risk, and Incident Dementia}}, journal = {American journal of preventive medicine}, year = {2023}, doi = {10.1016/j.amepre.2023.01.012}, pmid = {37085245}, url = {https://doi.org/10.1016/j.amepre.2023.01.012} } @article{godrich2025-41208712, author = {Godrich, Dana and Pasteris, Jeremy and Martin, Eden R. and Kunkle, Brian W. and Naj, Adam Christian and Hamilton, Kara and Wang, Hui and Lee, Wan‐Ping and others}, title = {{Genome‐wide association studies of TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70760}, pmid = {41208712}, url = {https://doi.org/10.1002/alz.70760} } @article{panyard2023-36744333, author = {Panyard, Daniel J and Deming, Yuetiva K and Darst, Burcu F and Van Hulle, Carol A and Zetterberg, Henrik and Blennow, Kaj and Kollmorgen, Gwendlyn and Suridjan, Ivonne and others}, title = {{Liver-Specific Polygenic Risk Score Is Associated with Alzheimer's Disease Diagnosis}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2023}, doi = {10.3233/jad-220599}, pmid = {36744333}, url = {https://doi.org/10.3233/jad-220599} } @article{ge2024-39023044, author = {Ge, Yi-Jun and Chen, Shi-Dong and Wu, Bang-Sheng and Zhang, Ya-Ru and Wang, Jun and He, Xiao-Yu and Liu, Wei-Shi and Chen, Yi-Lin and others}, title = {{Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.14121}, pmid = {39023044}, url = {https://doi.org/10.1002/alz.14121} } @article{li2017-26732597, author = {Li, Jie-Qiong and Wang, Hui-Fu and Zhu, Xi-Chen and Sun, Fu-Rong and Tan, Meng-Shan and Tan, Chen-Chen and Jiang, Teng and Tan, Lan and others}, title = {{GWAS-Linked Loci and Neuroimaging Measures in Alzheimer's Disease}}, journal = {Molecular neurobiology}, year = {2017}, doi = {10.1007/s12035-015-9669-1}, pmid = {26732597}, url = {https://doi.org/10.1007/s12035-015-9669-1} } @article{rubinski2023-36571564, author = {Rubinski, Anna and Frerich, Simon and Malik, Rainer and Franzmeier, Nicolai and Ramirez, Alfredo and Dichgans, Martin and Ewers, Michael}, title = {{Polygenic Effect on Tau Pathology Progression in Alzheimer's Disease}}, journal = {Annals of neurology}, year = {2023}, doi = {10.1002/ana.26588}, pmid = {36571564}, url = {https://doi.org/10.1002/ana.26588} } @article{zhao2019-31708967, author = {Zhao, Tianyi and Hu, Yang and Zang, Tianyi and Wang, Yadong}, title = {{Integrate GWAS, eQTL, and mQTL Data to Identify Alzheimer's Disease-Related Genes}}, journal = {Frontiers in genetics}, year = {2019}, doi = {10.3389/fgene.2019.01021}, pmid = {31708967}, url = {https://doi.org/10.3389/fgene.2019.01021} } @article{liu2017-27048444, author = {Liu, Guiyou and Xu, Yining and Jiang, Yongshuai and Zhang, Liangcai and Feng, Rennan and Jiang, Qinghua}, title = {{PICALM rs3851179 Variant Confers Susceptibility to Alzheimer's Disease in Chinese Population}}, journal = {Molecular neurobiology}, year = {2017}, doi = {10.1007/s12035-016-9886-2}, pmid = {27048444}, url = {https://doi.org/10.1007/s12035-016-9886-2} } @article{brookes2018-29914034, author = {Brookes, Keeley J and McConnell, George and Williams, Kirsty and Chaudhury, Sultan and Madhan, Gaganjit and Patel, Tulsi and Turley, Christopher and Guetta-Baranes, Tamar and others}, title = {{Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2018}, doi = {10.3233/jad-180191}, pmid = {29914034}, url = {https://doi.org/10.3233/jad-180191} } @article{ozaki2019-31588048, author = {Ozaki, Kouichi and Niida, Shumpei}, title = {{[Genetic Background for Alzheimer's Disease: Knowledge Accumulated from AD GWAS]}}, journal = {Brain and nerve = Shinkei kenkyu no shinpo}, year = {2019}, doi = {10.11477/mf.1416201403}, pmid = {31588048}, url = {https://doi.org/10.11477/mf.1416201403} } @article{choi2026-42937433, author = {Choi, Alex and Haystead, Alice and D'Cunha, Rachel and Hsu, John and Zhu, Michael and Johnson, Kim G and Whitson, Heather and Grewal, Dilraj S and others}, title = {{Longitudinal Multimodal Retinal Imaging in Cognitively Normal Apolipoprotein E4 Carriers and Noncarriers}}, journal = {Translational vision science \& technology}, year = {2026}, doi = {10.1167/tvst.15.10.45}, pmid = {42937433}, url = {https://doi.org/10.1167/tvst.15.10.45} } @article{saadmaan2026-40747850, author = {Saadmaan, Gazi and Dalmasso, Maria Carolina and Maria, Maleeha and Lehtisalo, Jenni and Hiltunen, Mikko and Kaikkonen, Minna U and Levälahti, Esko and Mangialasche, Francesca and others}, title = {{Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial}}, journal = {Brain : a journal of neurology}, year = {2026}, doi = {10.1093/brain/awaf277}, pmid = {40747850}, url = {https://doi.org/10.1093/brain/awaf277} } @article{ossenkoppele2020-32091549, author = {Ossenkoppele, R. and Lyoo, C. H. and Jester-Broms, J. and Sudre, C. H. and Cho, H. and Ryu, Y. H. and Choi, J. Y. and Smith, R. and others}, title = {{Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2019.5154}, pmid = {32091549}, url = {https://doi.org/10.1001/jamaneurol.2019.5154} } @article{antolini2021-34531298, author = {Antolini, L. and DiFrancesco, J. C. and Zedde, M. and Basso, G. and Arighi, A. and Shima, A. and Cagnin, A. and Caulo, M. and others}, title = {{Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012778}, pmid = {34531298}, url = {https://doi.org/10.1212/wnl.0000000000012778} } @article{pasqualetti2009-19448381, author = {Pasqualetti, P. and Bonomini, C. and Dal Forno, G. and Paulon, L. and Sinforiani, E. and Marra, C. and Zanetti, O. and Rossini, P. M.}, title = {{A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease}}, journal = {Aging clinical and experimental research}, year = {2009}, doi = {10.1007/bf03325217}, pmid = {19448381}, url = {https://doi.org/10.1007/bf03325217} } @article{vanrossum2012-23019259, author = {van Rossum, I. A. and Vos, S. J. and Burns, L. and Knol, D. L. and Scheltens, P. and Soininen, H. and Wahlund, L. O. and Hampel, H. and others}, title = {{Injury markers predict time to dementia in subjects with MCI and amyloid pathology}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182704056}, pmid = {23019259}, url = {https://doi.org/10.1212/wnl.0b013e3182704056} } @article{dourlen2017-27113998, author = {Dourlen, P. and Fernandez-Gomez, F. J. and Dupont, C. and Grenier-Boley, B. and Bellenguez, C. and Obriot, H. and Caillierez, R. and Sottejeau, Y. and others}, title = {{Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology}}, journal = {Molecular psychiatry}, year = {2017}, doi = {10.1038/mp.2016.59}, pmid = {27113998}, url = {https://doi.org/10.1038/mp.2016.59} } @article{hanson2013-23779114, author = {Hanson, A. J. and Bayer-Carter, J. L. and Green, P. S. and Montine, T. J. and Wilkinson, C. W. and Baker, L. D. and Watson, G. S. and Bonner, L. M. and others}, title = {{Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.396}, pmid = {23779114}, url = {https://doi.org/10.1001/jamaneurol.2013.396} } @article{leguen2022-35639372, author = {Le Guen, Y. and Belloy, M. E. and Grenier-Boley, B. and de Rojas, I. and Castillo-Morales, A. and Jansen, I. and Nicolas, A. and Bellenguez, C. and others}, title = {{Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.1166}, pmid = {35639372}, url = {https://doi.org/10.1001/jamaneurol.2022.1166} } @article{wetmore2024-39748836, author = {Wetmore, J. B. and Rodriguez, S. and Diaz Caro, D. and Cabán, M. and Uhlmann, W. and Goldman, J. and Leu, C. S. and Godinez, J. D. and others}, title = {{Designing and implementing the IDEAL Study: A randomized clinical trial of APOE genotype disclosure for late-onset Alzheimer's disease in an urban Latino population}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2024}, doi = {10.1002/trc2.70016}, pmid = {39748836}, url = {https://doi.org/10.1002/trc2.70016} } @article{betthauser2022-35856240, author = {Betthauser, T. J. and Bilgel, M. and Koscik, R. L. and Jedynak, B. M. and An, Y. and Kellett, K. A. and Moghekar, A. and Jonaitis, E. M. and others}, title = {{Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts}}, journal = {Brain : a journal of neurology}, year = {2022}, doi = {10.1093/brain/awac213}, pmid = {35856240}, url = {https://doi.org/10.1093/brain/awac213} } @article{shirzadi2023-37843849, author = {Shirzadi, Z. and Schultz, S. A. and Yau, W. W. and Joseph-Mathurin, N. and Fitzpatrick, C. D. and Levin, R. and Kantarci, K. and Preboske, G. M. and others}, title = {{Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3618}, pmid = {37843849}, url = {https://doi.org/10.1001/jamaneurol.2023.3618} } @article{morenograu2019-31473137, author = {Moreno-Grau, S. and de Rojas, I. and Hernández, I. and Quintela, I. and Montrreal, L. and Alegret, M. and Hernández-Olasagarre, B. and Madrid, L. and others}, title = {{Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.06.4950}, pmid = {31473137}, url = {https://doi.org/10.1016/j.jalz.2019.06.4950} } @article{majounie2012-22406228, author = {Majounie, E. and Renton, A. E. and Mok, K. and Dopper, E. G. and Waite, A. and Rollinson, S. and Chiò, A. and Restagno, G. and others}, title = {{Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2012}, doi = {10.1016/s1474-4422(12)70043-1}, pmid = {22406228}, url = {https://doi.org/10.1016/s1474-4422(12)70043-1} } @article{ott1998-9652667, author = {Ott, A. and Slooter, A. J. and Hofman, A. and van Harskamp, F. and Witteman, J. C. and Van Broeckhoven, C. and van Duijn, C. M. and Breteler, M. M.}, title = {{Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study}}, journal = {Lancet (London, England)}, year = {1998}, doi = {10.1016/s0140-6736(97)07541-7}, pmid = {9652667}, url = {https://doi.org/10.1016/s0140-6736(97)07541-7} } @article{eliassonnenschein2011-21493755, author = {Elias-Sonnenschein, L. S. and Viechtbauer, W. and Ramakers, I. H. and Verhey, F. R. and Visser, P. J.}, title = {{Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2011}, doi = {10.1136/jnnp.2010.231555}, pmid = {21493755}, url = {https://doi.org/10.1136/jnnp.2010.231555} } @article{jin2015-25886450, author = {Jin, S. C. and Carrasquillo, M. M. and Benitez, B. A. and Skorupa, T. and Carrell, D. and Patel, D. and Lincoln, S. and Krishnan, S. and others}, title = {{TREM2 is associated with increased risk for Alzheimer's disease in African Americans}}, journal = {Molecular neurodegeneration}, year = {2015}, doi = {10.1186/s13024-015-0016-9}, pmid = {25886450}, url = {https://doi.org/10.1186/s13024-015-0016-9} } @article{liu2016-26365049, author = {Liu, G. and Liu, Y. and Jiang, Q. and Jiang, Y. and Feng, R. and Zhang, L. and Chen, Z. and Li, K. and others}, title = {{Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility}}, journal = {Molecular neurobiology}, year = {2016}, doi = {10.1007/s12035-015-9416-7}, pmid = {26365049}, url = {https://doi.org/10.1007/s12035-015-9416-7} } @article{calvin2022-36125811, author = {Calvin, C. M. and Conroy, M. C. and Moore, S. F. and Kuzma, E. and Littlejohns, T. J.}, title = {{Association of Multimorbidity, Disease Clusters, and Modification by Genetic Factors With Risk of Dementia}}, journal = {JAMA network open}, year = {2022}, doi = {10.1001/jamanetworkopen.2022.32124}, pmid = {36125811}, url = {https://doi.org/10.1001/jamanetworkopen.2022.32124} } @article{jansen2019-30617256, author = {Jansen, Iris E. and Savage, Jeanne E. and Watanabe, Kyoko and Bryois, Julien and Williams, Dylan M. and Steinberg, Stacy and Sealock, Julia and Karlsson, Ida and others}, title = {{Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk}}, journal = {Nature Genetics}, year = {2019}, doi = {10.1038/s41588-018-0311-9}, pmid = {30617256}, url = {https://doi.org/10.1038/s41588-018-0311-9} } @article{yakoub2023-37294682, author = {Yakoub, Y. and Ashton, N. J. and Strikwerda-Brown, C. and Montoliu-Gaya, L. and Karikari, T. K. and Kac, P. R. and Gonzalez-Ortiz, F. and Gallego-Rudolf, J. and others}, title = {{Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.13318}, pmid = {37294682}, url = {https://doi.org/10.1002/alz.13318} } @article{stocker2023-37516890, author = {Stocker, H. and Trares, K. and Beyer, L. and Perna, L. and Rujescu, D. and Holleczek, B. and Beyreuther, K. and Gerwert, K. and others}, title = {{Alzheimer's polygenic risk scores, APOE, Alzheimer's disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years}}, journal = {Alzheimer's research \& therapy}, year = {2023}, doi = {10.1186/s13195-023-01277-8}, pmid = {37516890}, url = {https://doi.org/10.1186/s13195-023-01277-8} } @article{dejager2018-30084846, author = {De Jager, P. L. and Ma, Y. and McCabe, C. and Xu, J. and Vardarajan, B. N. and Felsky, D. and Klein, H. U. and White, C. C. and others}, title = {{A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research}}, journal = {Scientific data}, year = {2018}, doi = {10.1038/sdata.2018.142}, pmid = {30084846}, url = {https://doi.org/10.1038/sdata.2018.142} } @article{kamboh2012-22832961, author = {Kamboh, M. I. and Demirci, F. Y. and Wang, X. and Minster, R. L. and Carrasquillo, M. M. and Pankratz, V. S. and Younkin, S. G. and Saykin, A. J. and others}, title = {{Genome-wide association study of Alzheimer's disease}}, journal = {Translational psychiatry}, year = {2012}, doi = {10.1038/tp.2012.45}, pmid = {22832961}, url = {https://doi.org/10.1038/tp.2012.45} } @article{pilling2017-29227965, author = {Pilling, L. C. and Kuo, C. L. and Sicinski, K. and Tamosauskaite, J. and Kuchel, G. A. and Harries, L. W. and Herd, P. and Wallace, R. and others}, title = {{Human longevity: 25 genetic loci associated in 389,166 UK biobank participants}}, journal = {Aging}, year = {2017}, doi = {10.18632/aging.101334}, pmid = {29227965}, url = {https://doi.org/10.18632/aging.101334} } @article{fortney2015-26677855, author = {Fortney, Kristen and Dobriban, Edgar and Garagnani, Paolo and Pirazzini, Chiara and Monti, Daniela and Mari, Daniela and Atzmon, Gil and Barzilai, Nir and others}, title = {{Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity}}, journal = {PLoS Genetics}, year = {2015}, doi = {10.1371/journal.pgen.1005728}, pmid = {26677855}, url = {https://doi.org/10.1371/journal.pgen.1005728} } @article{shulman2013-24067533, author = {Shulman, Joshua M and Imboywa, Selina H. and Γιαγτζόγλου, Νικόλαος and Powers, Martin P. and Hu, Yanhui and Devenport, Danelle and Chipendo, Portia I. and Chibnik, Lori Beth and others}, title = {{Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms}}, journal = {Human Molecular Genetics}, year = {2013}, doi = {10.1093/hmg/ddt478}, pmid = {24067533}, url = {https://doi.org/10.1093/hmg/ddt478} }