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% Source: https://alzhub.org/research?institution=I1283280774&about=genetics
% 97 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{salloway2014-24450891,
  author  = {Salloway, S. and Sperling, R. and Fox, N. C. and Blennow, K. and Klunk, W. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others},
  title   = {{Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease}},
  journal = {The New England journal of medicine},
  year    = {2014},
  doi     = {10.1056/nejmoa1304839},
  pmid    = {24450891},
  url     = {https://doi.org/10.1056/nejmoa1304839}
}

@article{naj2011-21460841,
  author  = {Naj, A. C. and Jun, G. and Beecham, G. W. and Wang, L. S. and Vardarajan, B. N. and Buros, J. and Gallins, P. J. and Buxbaum, J. D. and others},
  title   = {{Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2011},
  doi     = {10.1038/ng.801},
  pmid    = {21460841},
  url     = {https://doi.org/10.1038/ng.801}
}

@article{sims2017-28714976,
  author  = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others},
  title   = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2017},
  doi     = {10.1038/ng.3916},
  pmid    = {28714976},
  url     = {https://doi.org/10.1038/ng.3916}
}

@article{jun2016-25778476,
  author  = {Jun, G. and Ibrahim-Verbaas, C. A. and Vronskaya, M. and Lambert, J. C. and Chung, J. and Naj, A. C. and Kunkle, B. W. and Wang, L. S. and others},
  title   = {{A novel Alzheimer disease locus located near the gene encoding tau protein}},
  journal = {Molecular psychiatry},
  year    = {2016},
  doi     = {10.1038/mp.2015.23},
  pmid    = {25778476},
  url     = {https://doi.org/10.1038/mp.2015.23}
}

@article{sherva2023-36543923,
  author  = {Sherva, R. and Zhang, R. and Sahelijo, N. and Jun, G. and Anglin, T. and Chanfreau, C. and Cho, K. and Fonda, JR. and others},
  title   = {{African ancestry GWAS of dementia in a large military cohort identifies significant risk loci}},
  journal = {Molecular psychiatry},
  year    = {2023},
  doi     = {10.1038/s41380-022-01890-3},
  pmid    = {36543923},
  url     = {https://doi.org/10.1038/s41380-022-01890-3}
}

@article{leguen2023-36809323,
  author  = {Le Guen, Y. and Raulin, A. C. and Logue, M. W. and Sherva, R. and Belloy, M. E. and Eger, S. J. and Chen, A. and Kennedy, G. and Kuchenbecker, L. and O'Leary, J. P. and Zhang, R. and Merritt, V. C. and others},
  title   = {{Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease}},
  journal = {JAMA},
  year    = {2023},
  doi     = {10.1001/jama.2023.0268},
  pmid    = {36809323},
  url     = {https://doi.org/10.1001/jama.2023.0268}
}

@article{quiroz2024-38899694,
  author  = {Quiroz, Y. T. and Aguillon, D. and Aguirre-Acevedo, D. C. and Vasquez, D. and Zuluaga, Y. and Baena, A. Y. and Madrigal, L. and Hincapié, L. and Sanchez, J. S. and Langella, S. and Posada-Duque, R. and Littau, J. L. and others},
  title   = {{APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease}},
  journal = {New England Journal of Medicine},
  year    = {2024},
  doi     = {10.1056/NEJMoa2308583},
  pmid    = {38899694},
  url     = {https://doi.org/10.1056/NEJMoa2308583}
}

@article{naj2014-25199842,
  author  = {Naj, A. C. and Jun, G. and Reitz, C. and Kunkle, B. W. and Perry, W. and Park, Y. S. and Beecham, G. W. and Rajbhandary, R. A. and others},
  title   = {{Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1491},
  pmid    = {25199842},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1491}
}

@article{hohman2018-29801024,
  author  = {Hohman, T. J. and Dumitrescu, L. and Barnes, L. L. and Thambisetty, M. and Beecham, G. and Kunkle, B. and Gifford, K. A. and Bush, W. S. and others},
  title   = {{Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2018.0821},
  pmid    = {29801024},
  url     = {https://doi.org/10.1001/jamaneurol.2018.0821}
}

@article{parhizkar2019-30617257,
  author  = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others},
  title   = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-018-0296-9},
  pmid    = {30617257},
  url     = {https://doi.org/10.1038/s41593-018-0296-9}
}

@article{roostaei2017-27021820,
  author  = {Roostaei, T. and Nazeri, A. and Felsky, D. and De Jager, P. L. and Schneider, J. A. and Pollock, B. G. and Bennett, D. A. and Voineskos, A. N. and others},
  title   = {{Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease}},
  journal = {Molecular psychiatry},
  year    = {2017},
  doi     = {10.1038/mp.2016.35},
  pmid    = {27021820},
  url     = {https://doi.org/10.1038/mp.2016.35}
}

@article{tessier2024-38709531,
  author  = {Tessier, A. J. and Cortese, M. and Yuan, C. and Bjornevik, K. and Ascherio, A. and Wang, D. D. and Chavarro, J. E. and Stampfer, M. J. and Hu, F. B. and Willett, W. C. and others},
  title   = {{Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death}},
  journal = {JAMA Network Open},
  year    = {2024},
  doi     = {10.1001/jamanetworkopen.2024.10021},
  pmid    = {38709531},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.10021}
}

@article{sargurupremraj2020-33293549,
  author  = {Sargurupremraj, M. and Suzuki, H. and Jian, X. and Sarnowski, C. and Evans, T. E. and Bis, J. C. and Eiriksdottir, G. and Sakaue, S. and others},
  title   = {{Cerebral small vessel disease genomics and its implications across the lifespan}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-19111-2},
  pmid    = {33293549},
  url     = {https://doi.org/10.1038/s41467-020-19111-2}
}

@article{dube2019-31591557,
  author  = {Dube, U. and Del-Aguila, J. L. and Li, Z. and Budde, J. P. and Jiang, S. and Hsu, S. and Ibanez, L. and Fernandez, M. V. and others},
  title   = {{An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0501-5},
  pmid    = {31591557},
  url     = {https://doi.org/10.1038/s41593-019-0501-5}
}

@article{szwedo2022-35106798,
  author  = {Szwedo, A. A. and Dalen, I. and Pedersen, K. F. and Camacho, M. and Bäckström, D. and Forsgren, L. and Tzoulis, C. and Winder-Rhodes, S. and others},
  title   = {{GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2022},
  doi     = {10.1002/mds.28932},
  pmid    = {35106798},
  url     = {https://doi.org/10.1002/mds.28932}
}

@article{verhaaren2015-25663218,
  author  = {Verhaaren, B. F. and Debette, S. and Bis, J. C. and Smith, J. A. and Ikram, M. K. and Adams, H. H. and Beecham, A. H. and Rajan, K. B. and others},
  title   = {{Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI}},
  journal = {Circulation. Cardiovascular genetics},
  year    = {2015},
  doi     = {10.1161/circgenetics.114.000858},
  pmid    = {25663218},
  url     = {https://doi.org/10.1161/circgenetics.114.000858}
}

@article{christensen2018-28726810,
  author  = {Christensen, K. D. and Uhlmann, W. R. and Roberts, J. S. and Linnenbringer, E. and Whitehouse, P. J. and Royal, C. D. M. and Obisesan, T. O. and Cupples, L. A. and others},
  title   = {{A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone}},
  journal = {Genetics in medicine : official journal of the American College of Medical Genetics},
  year    = {2018},
  doi     = {10.1038/gim.2017.103},
  pmid    = {28726810},
  url     = {https://doi.org/10.1038/gim.2017.103}
}

@article{fortea2024-38710950,
  author  = {Fortea, J. and Pegueroles, J. and Alcolea, D. and Belbin, O. and Dols-Icardo, O. and Vaqué-Alcázar, L. and Videla, L. and Gispert, J. D. and others},
  title   = {{APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2024},
  doi     = {10.1038/s41591-024-02931-w},
  pmid    = {38710950},
  url     = {https://doi.org/10.1038/s41591-024-02931-w}
}

@article{sperling2020-32250387,
  author  = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Sun, C. K. and Yaari, R. and Holdridge, K. and Siemers, E. and Johnson, K. A. and others},
  title   = {{Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.0387},
  pmid    = {32250387},
  url     = {https://doi.org/10.1001/jamaneurol.2020.0387}
}

@article{yu2015-25365775,
  author  = {Yu, L. and Chibnik, L. B. and Srivastava, G. P. and Pochet, N. and Yang, J. and Xu, J. and Kozubek, J. and Obholzer, N. and others},
  title   = {{Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.3049},
  pmid    = {25365775},
  url     = {https://doi.org/10.1001/jamaneurol.2014.3049}
}

@article{ayton2015-25988319,
  author  = {Ayton, S. and Faux, N. G. and Bush, A. I. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE}},
  journal = {Nature communications},
  year    = {2015},
  doi     = {10.1038/ncomms7760},
  pmid    = {25988319},
  url     = {https://doi.org/10.1038/ncomms7760}
}

@article{carrasquillo2017-27939925,
  author  = {Carrasquillo, M. M. and Allen, M. and Burgess, J. D. and Wang, X. and Strickland, S. L. and Aryal, S. and Siuda, J. and Kachadoorian, M. L. and others},
  title   = {{A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.10.005},
  pmid    = {27939925},
  url     = {https://doi.org/10.1016/j.jalz.2016.10.005}
}

@article{shirzadi2023-37843849,
  author  = {Shirzadi, Z. and Schultz, S. A. and Yau, W. W. and Joseph-Mathurin, N. and Fitzpatrick, C. D. and Levin, R. and Kantarci, K. and Preboske, G. M. and others},
  title   = {{Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.3618},
  pmid    = {37843849},
  url     = {https://doi.org/10.1001/jamaneurol.2023.3618}
}

@article{buckley2019-30715078,
  author  = {Buckley, R. F. and Mormino, E. C. and Rabin, J. S. and Hohman, T. J. and Landau, S. and Hanseeuw, B. J. and Jacobs, H. I. L. and Papp, K. V. and others},
  title   = {{Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2018.4693},
  pmid    = {30715078},
  url     = {https://doi.org/10.1001/jamaneurol.2018.4693}
}

@article{amariglio2015-25706191,
  author  = {Amariglio, R. E. and Donohue, M. C. and Marshall, G. A. and Rentz, D. M. and Salmon, D. P. and Ferris, S. H. and Karantzoulis, S. and Aisen, P. S. and others},
  title   = {{Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.3375},
  pmid    = {25706191},
  url     = {https://doi.org/10.1001/jamaneurol.2014.3375}
}

@article{liu2015-26208959,
  author  = {Liu, E. and Schmidt, M. E. and Margolin, R. and Sperling, R. and Koeppe, R. and Mason, N. S. and Klunk, W. E. and Mathis, C. A. and others},
  title   = {{Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000001877},
  pmid    = {26208959},
  url     = {https://doi.org/10.1212/wnl.0000000000001877}
}

@article{liu2017-28629879,
  author  = {Liu, G. and Locascio, J. J. and Corvol, J. C. and Boot, B. and Liao, Z. and Page, K. and Franco, D. and Burke, K. and others},
  title   = {{Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts}},
  journal = {The Lancet. Neurology},
  year    = {2017},
  doi     = {10.1016/s1474-4422(17)30122-9},
  pmid    = {28629879},
  url     = {https://doi.org/10.1016/s1474-4422(17)30122-9}
}

@article{lambert2013-24162737,
  author  = {Lambert, Jean‐Charles and Ibrahim‐Verbaas, Carla A. and Harold, Denise H. and Naj, Adam Christian and Sims, Rebecca and Bellenguez, Céline and others},
  title   = {{Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2013},
  doi     = {10.1038/ng.2802},
  pmid    = {24162737},
  url     = {https://doi.org/10.1038/ng.2802}
}

@article{shi2017-28959956,
  author  = {Shi, Y. and Yamada, K. and Liddelow, S. A. and Smith, S. T. and Zhao, L. and Luo, W. and Tsai, R. M. and Spina, S. and others},
  title   = {{ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy}},
  journal = {Nature},
  year    = {2017},
  doi     = {10.1038/nature24016},
  pmid    = {28959956},
  url     = {https://doi.org/10.1038/nature24016}
}

@article{donohue2014-24886908,
  author  = {Donohue, M. C. and Sperling, R. A. and Salmon, D. P. and Rentz, D. M. and Raman, R. and Thomas, R. G. and Weiner, M. and Aisen, P. S. and others},
  title   = {{The preclinical Alzheimer cognitive composite: measuring amyloid-related decline}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.803},
  pmid    = {24886908},
  url     = {https://doi.org/10.1001/jamaneurol.2014.803}
}

@article{mormino2014-24748674,
  author  = {Mormino, E. C. and Betensky, R. A. and Hedden, T. and Schultz, A. P. and Ward, A. and Huijbers, W. and Rentz, D. M. and Johnson, K. A. and others},
  title   = {{Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000431},
  pmid    = {24748674},
  url     = {https://doi.org/10.1212/wnl.0000000000000431}
}

@article{christensen2016-26810768,
  author  = {Christensen, K. D. and Roberts, J. S. and Whitehouse, P. J. and Royal, C. D. and Obisesan, T. O. and Cupples, L. A. and Vernarelli, J. A. and Bhatt, D. L. and others},
  title   = {{Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial}},
  journal = {Annals of internal medicine},
  year    = {2016},
  doi     = {10.7326/m15-0187},
  pmid    = {26810768},
  url     = {https://doi.org/10.7326/m15-0187}
}

@article{ge2018-29592889,
  author  = {Ge, T. and Sabuncu, M. R. and Smoller, J. W. and Sperling, R. A. and Mormino, E. C. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000005415},
  pmid    = {29592889},
  url     = {https://doi.org/10.1212/wnl.0000000000005415}
}

@article{beecham2014-25188341,
  author  = {Beecham, G. W. and Hamilton, K. and Naj, A. C. and Martin, E. R. and Huentelman, M. and Myers, A. J. and Corneveaux, J. J. and Hardy, J. and others},
  title   = {{Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias}},
  journal = {PLoS genetics},
  year    = {2014},
  doi     = {10.1371/journal.pgen.1004606},
  pmid    = {25188341},
  url     = {https://doi.org/10.1371/journal.pgen.1004606}
}

@article{hofmann2024-39557867,
  author  = {Hofmann, A. and Häsler, L. M. and Lambert, M. and Kaeser, S. A. and Gräber-Sultan, S. and Obermüller, U. and Kuder-Buletta, E. and la Fougere, C. and others},
  title   = {{Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-52937-8},
  pmid    = {39557867},
  url     = {https://doi.org/10.1038/s41467-024-52937-8}
}

@article{reiman2012-23137948,
  author  = {Reiman, E. M. and Quiroz, Y. T. and Fleisher, A. S. and Chen, K. and Velez-Pardo, C. and Jimenez-Del-Rio, M. and Fagan, A. M. and Shah, A. R. and others},
  title   = {{Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study}},
  journal = {The Lancet. Neurology},
  year    = {2012},
  doi     = {10.1016/s1474-4422(12)70228-4},
  pmid    = {23137948},
  url     = {https://doi.org/10.1016/s1474-4422(12)70228-4}
}

@article{krasemann2017-28930663,
  author  = {Krasemann, S. and Madore, C. and Cialic, R. and Baufeld, C. and Calcagno, N. and El Fatimy, R. and Beckers, L. and O'Loughlin, E. and others},
  title   = {{The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases}},
  journal = {Immunity},
  year    = {2017},
  doi     = {10.1016/j.immuni.2017.08.008},
  pmid    = {28930663},
  url     = {https://doi.org/10.1016/j.immuni.2017.08.008}
}

@article{grill2026-41910973,
  author  = {Grill, Joshua D. and RAMAN, REMA and Wang, Shunran and Ernstrom, Karin B. and Andrews, Patricia and Appleby, Brian Stephen and Bhangu, Jaspreet S. and Dhadda, Shobha and others},
  title   = {{Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress}},
  journal = {JAMA Network Open},
  year    = {2026},
  doi     = {10.1001/jamanetworkopen.2026.3845},
  pmid    = {41910973},
  url     = {https://doi.org/10.1001/jamanetworkopen.2026.3845}
}

@article{schultz2024-39074479,
  author  = {Schultz, S. A. and Liu, L. and Schultz, A. P. and Fitzpatrick, C. D. and Levin, R. and Bellier, J. P. and Shirzadi, Z. and Joseph-Mathurin, N. and others},
  title   = {{γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)}},
  journal = {The Lancet. Neurology},
  year    = {2024},
  doi     = {10.1016/s1474-4422(24)00236-9},
  pmid    = {39074479},
  url     = {https://doi.org/10.1016/s1474-4422(24)00236-9}
}

@article{roberts2012-22498844,
  author  = {Roberts, J. S. and Chen, C. A. and Uhlmann, W. R. and Green, R. C.},
  title   = {{Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease}},
  journal = {Genetics in medicine : official journal of the American College of Medical Genetics},
  year    = {2012},
  doi     = {10.1038/gim.2012.37},
  pmid    = {22498844},
  url     = {https://doi.org/10.1038/gim.2012.37}
}

@article{yu2017-28108637,
  author  = {Yu, L. and Lutz, M. W. and Wilson, R. S. and Burns, D. K. and Roses, A. D. and Saunders, A. M. and Gaiteri, C. and De Jager, P. L. and others},
  title   = {{TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype}},
  journal = {Neurology},
  year    = {2017},
  doi     = {10.1212/wnl.0000000000003614},
  pmid    = {28108637},
  url     = {https://doi.org/10.1212/wnl.0000000000003614}
}

@article{reiman2020-32015339,
  author  = {Reiman, E. M. and Arboleda-Velasquez, J. F. and Quiroz, Y. T. and Huentelman, M. J. and Beach, T. G. and Caselli, R. J. and Chen, Y. and Su, Y. and others},
  title   = {{Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-019-14279-8},
  pmid    = {32015339},
  url     = {https://doi.org/10.1038/s41467-019-14279-8}
}

@article{selkoe2016-27025652,
  author  = {Selkoe, Dennis J. and Hardy, John},
  title   = {{The amyloid hypothesis of Alzheimer's disease at 25 years}},
  journal = {EMBO Molecular Medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201606210},
  pmid    = {27025652},
  url     = {https://doi.org/10.15252/emmm.201606210}
}

@article{boerwinkle2023-36517172,
  author  = {Boerwinkle, A. H. and Gordon, B. A. and Wisch, J. and Flores, S. and Henson, R. L. and Butt, O. H. and McKay, N. and Chen, C. D. and others},
  title   = {{Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study}},
  journal = {The Lancet. Neurology},
  year    = {2023},
  doi     = {10.1016/s1474-4422(22)00408-2},
  pmid    = {36517172},
  url     = {https://doi.org/10.1016/s1474-4422(22)00408-2}
}

@article{mormino2016-27385740,
  author  = {Mormino, E. C. and Sperling, R. A. and Holmes, A. J. and Buckner, R. L. and De Jager, P. L. and Smoller, J. W. and Sabuncu, M. R. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Polygenic risk of Alzheimer disease is associated with early- and late-life processes}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000002922},
  pmid    = {27385740},
  url     = {https://doi.org/10.1212/wnl.0000000000002922}
}

@article{quiroz2018-29435558,
  author  = {Quiroz, Y. T. and Sperling, R. A. and Norton, D. J. and Baena, A. and Arboleda-Velasquez, J. F. and Cosio, D. and Schultz, A. and Lapoint, M. and others},
  title   = {{Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2017.4907},
  pmid    = {29435558},
  url     = {https://doi.org/10.1001/jamaneurol.2017.4907}
}

@article{thomas2014-25069482,
  author  = {Thomas, J. B. and Brier, M. R. and Bateman, R. J. and Snyder, A. Z. and Benzinger, T. L. and Xiong, C. and Raichle, M. and Holtzman, D. M. and others},
  title   = {{Functional connectivity in autosomal dominant and late-onset Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1654},
  pmid    = {25069482},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1654}
}

@article{chan2015-26414614,
  author  = {Chan, G. and White, C. C. and Winn, P. A. and Cimpean, M. and Replogle, J. M. and Glick, L. R. and Cuerdon, N. E. and Ryan, K. J. and others},
  title   = {{CD33 modulates TREM2: convergence of Alzheimer loci}},
  journal = {Nature neuroscience},
  year    = {2015},
  doi     = {10.1038/nn.4126},
  pmid    = {26414614},
  url     = {https://doi.org/10.1038/nn.4126}
}

@article{liang2025-39836940,
  author  = {Liang, Jingjing and Hussainy, Sadiya and Lee, Sara Michelle and Wu, Gray and Bautista, Natalie and Ding, Mao and Wang, Heming and LAFLEUR, BONNIE J. and others},
  title   = {{Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000210250},
  pmid    = {39836940},
  url     = {https://doi.org/10.1212/wnl.0000000000210250}
}

@article{lopera2023-37188781,
  author  = {Lopera, F. and Marino, C. and Chandrahas, A. S. and O'Hare, M. and Villalba-Moreno, N. D. and Aguillon, D. and Baena, A. and Sanchez, J. S. and Vila-Castelar, C. and Ramirez Gomez, L. and Chmielewska, N. and Oliveira, G. M. and others},
  title   = {{Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man}},
  journal = {Nature Medicine},
  year    = {2023},
  doi     = {10.1038/s41591-023-02318-3},
  pmid    = {37188781},
  url     = {https://doi.org/10.1038/s41591-023-02318-3}
}

@article{cash2013-24049139,
  author  = {Cash, D. M. and Ridgway, G. R. and Liang, Y. and Ryan, N. S. and Kinnunen, K. M. and Yeatman, T. and Malone, I. B. and Benzinger, T. L. and others},
  title   = {{The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study}},
  journal = {Neurology},
  year    = {2013},
  doi     = {10.1212/wnl.0b013e3182a841c6},
  pmid    = {24049139},
  url     = {https://doi.org/10.1212/wnl.0b013e3182a841c6}
}

@article{scheuner1996-8705854,
  author  = {Scheuner, Donalyn and Eckman, Christopher B. and Jensen, M. and Song, X.H. and Citron, Martin and Suzuki, Nobuhiro and Bird, Thomas D. and Hardy, John and Hutton, Melanie L. and Kukull, Walter A. and Larson, Eric B. and Levy‐Lahad, Ephrat and Viitanen, Matti H. and Peskind, Elaine R. and Poorkaj, Parvoneh and Schellenberg, Gerald D. and Tanzi, Rudolph E. and Wasco, Wilma and Lannfelt, Lars and Selkoe, Dennis J. and Younkin, Samuel G.},
  title   = {{Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease}},
  journal = {Nature Medicine},
  year    = {1996},
  doi     = {10.1038/nm0896-864},
  pmid    = {8705854},
  url     = {https://doi.org/10.1038/nm0896-864}
}

@article{wolfe1999-10206644,
  author  = {Wolfe, Michael S. and Xia, Weiming and Ostaszewski, Beth L. and Diehl, Thekla S. and Kimberly, William Taylor and Selkoe, Dennis J.},
  title   = {{Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity}},
  journal = {Nature},
  year    = {1999},
  doi     = {10.1038/19077},
  pmid    = {10206644},
  url     = {https://doi.org/10.1038/19077}
}

@article{buckley2018-29803541,
  author  = {Buckley, R. F. and Mormino, E. C. and Amariglio, R. E. and Properzi, M. J. and Rabin, J. S. and Lim, Y. Y. and Papp, K. V. and Jacobs, H. I. L. and others},
  title   = {{Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2018},
  doi     = {10.1016/j.jalz.2018.04.010},
  pmid    = {29803541},
  url     = {https://doi.org/10.1016/j.jalz.2018.04.010}
}

@article{conway1998-9809558,
  author  = {Conway, K. A. and Harper, J. D. and Lansbury, P. T.},
  title   = {{Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease}},
  journal = {Nature medicine},
  year    = {1998},
  doi     = {10.1038/3311},
  pmid    = {9809558},
  url     = {https://doi.org/10.1038/3311}
}

@article{jay2015-25732305,
  author  = {Jay, T. R. and Miller, C. M. and Cheng, P. J. and Graham, L. C. and Bemiller, S. and Broihier, M. L. and Xu, G. and Margevicius, D. and others},
  title   = {{TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models}},
  journal = {The Journal of experimental medicine},
  year    = {2015},
  doi     = {10.1084/jem.20142322},
  pmid    = {25732305},
  url     = {https://doi.org/10.1084/jem.20142322}
}

@article{selkoe2001-11274343,
  author  = {Selkoe, Dennis J.},
  title   = {{Alzheimer's Disease: Genes, Proteins, and Therapy}},
  journal = {Physiological Reviews},
  year    = {2001},
  doi     = {10.1152/physrev.2001.81.2.741},
  pmid    = {11274343},
  url     = {https://doi.org/10.1152/physrev.2001.81.2.741}
}

@article{citron1992-1465129,
  author  = {Citron, Martin and Oltersdorf, Tilman and Haass, Christian and McConlogue, Lisa and Hung, Albert Y. and Seubert, Peter A. and Vigo‐Pelfrey, Carmen and Lieberburg, Ivan M. and Selkoe, Dennis J.},
  title   = {{Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production}},
  journal = {Nature},
  year    = {1992},
  doi     = {10.1038/360672a0},
  pmid    = {1465129},
  url     = {https://doi.org/10.1038/360672a0}
}

@article{ali2023-37101235,
  author  = {Ali, M. and Archer, D. B. and Gorijala, P. and Western, D. and Timsina, J. and Fernández, M. V. and Wang, T. C. and Satizabal, C. L. and others},
  title   = {{Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease}},
  journal = {Acta neuropathologica communications},
  year    = {2023},
  doi     = {10.1186/s40478-023-01563-4},
  pmid    = {37101235},
  url     = {https://doi.org/10.1186/s40478-023-01563-4}
}

@article{shulman2013-23836404,
  author  = {Shulman, J. M. and Chen, K. and Keenan, B. T. and Chibnik, L. B. and Fleisher, A. and Thiyyagura, P. and Roontiva, A. and McCabe, C. and others},
  title   = {{Genetic susceptibility for Alzheimer disease neuritic plaque pathology}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.2815},
  pmid    = {23836404},
  url     = {https://doi.org/10.1001/jamaneurol.2013.2815}
}

@article{liu2025-40855194,
  author  = {Liu, Yuxi and Gu, Xiao and Li, Yanping and Wang, Fenglei and Vyas, Chirag M. and Peng, Cheng and Dong, Danyue and Li, Yuhan and others},
  title   = {{Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function}},
  journal = {Nature Medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03891-5},
  pmid    = {40855194},
  url     = {https://doi.org/10.1038/s41591-025-03891-5}
}

@article{li2026-41535386,
  author  = {Li, Jun and Hu, Jie and Yun, Huan and Mei, Zhendong and Wang, Xingyan and Luo, Kai and Guasch‐Ferré, Marta and Han, Xikun and others},
  title   = {{Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes}},
  journal = {Nature Medicine},
  year    = {2026},
  doi     = {10.1038/s41591-025-04105-8},
  pmid    = {41535386},
  url     = {https://doi.org/10.1038/s41591-025-04105-8}
}

@article{liu2025-39903689,
  author  = {Liu, Haiyan and Marsh, Thomas W. and Shi, Xinyu and Renton, Alan Edward and Bowling, Kevin M. and Ziegemeier, Ellen and Wang, Guoqiao and Cao, Yuchen and others},
  title   = {{The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awaf038},
  pmid    = {39903689},
  url     = {https://doi.org/10.1093/brain/awaf038}
}

@article{wang2025-41299092,
  author  = {Wang, Yunhe and Xiao, Sihao and Liu, Bowen and Jiang, Rongtao and Liu, Yuxi and Hang, Yian and Chen, Li and Chen, Runsen and others},
  title   = {{Organ-specific proteomic aging clocks predict disease and longevity across diverse populations}},
  journal = {Nature Aging},
  year    = {2025},
  doi     = {10.1038/s43587-025-01016-8},
  pmid    = {41299092},
  url     = {https://doi.org/10.1038/s43587-025-01016-8}
}

@article{cruchaga2013-23562540,
  author  = {Cruchaga, Carlos C and Kauwe, John S. K. and Harari, Oscar and Jin, Sheng Chih and Cai, Yefei and Karch, Celeste M M. and Benítez, Bruno A. and Jeng, Amanda T. and Skorupa, Tara and Carrell, David and Bertelsen, Sarah E. and Bailey, Matthew H. and McKean, David M. and Shulman, Joshua M and De Jager, Philip L. and Chibnik, Lori Beth and Bennett, David and Arnold, S. E. and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Williams, Julie H. and Van Deerlin, Vivianna M. and Lee, Virginia M.‐Y. and Shaw, Leslie M. and Trojanowski, John Q. and Haines, Jonathan L. and Mayeux, Richard P and Pericak‐Vance, Margaret A. and Farrer, Lindsay A. and Schellenberg, Gerard D. and Peskind, Elaine R. and Galasko, Douglas R and Fagan, Anne M. and Holtzman, David M. and Morris, John C. and Goate, Alison},
  title   = {{GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease}},
  journal = {Neuron},
  year    = {2013},
  doi     = {10.1016/j.neuron.2013.02.026},
  pmid    = {23562540},
  url     = {https://doi.org/10.1016/j.neuron.2013.02.026}
}

@article{kurniansyah2026-42661068,
  author  = {Kurniansyah, N. and Tasaki, S. and Rehman, H. and Zhu, C. and Farrell, J. and Sherva, R. and Hauger, R. and Merritt, V. C. and Panizzon, M. and Zhang, R. and Gaziano, J. M. and Gim, J. and others},
  title   = {{A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations}},
  journal = {Nature genetics},
  year    = {2026},
  doi     = {10.1038/s41588-026-02722-8},
  pmid    = {42661068},
  url     = {https://doi.org/10.1038/s41588-026-02722-8}
}

@article{fleisher2013-22633529,
  author  = {Fleisher, A. S. and Chen, K. and Liu, X. and Ayutyanont, N. and Roontiva, A. and Thiyyagura, P. and Protas, H. and Joshi, A. D. and others},
  title   = {{Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2012.04.017},
  pmid    = {22633529},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2012.04.017}
}

@article{mazaheri2017-28483841,
  author  = {Mazaheri, F. and Snaidero, N. and Kleinberger, G. and Madore, C. and Daria, A. and Werner, G. and Krasemann, S. and Capell, A. and others},
  title   = {{TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury}},
  journal = {EMBO reports},
  year    = {2017},
  doi     = {10.15252/embr.201743922},
  pmid    = {28483841},
  url     = {https://doi.org/10.15252/embr.201743922}
}

@article{farris2003-12634421,
  author  = {Farris, Wesley and Mansourian, Stefan and Chang, Yang and Lindsley, Loren D. and Eckman, Elizabeth A. and Frosch, Matthew P. and Eckman, Christopher B. and Tanzi, Rudolph E. and Selkoe, Dennis J. and Guénette, Suzanne Y.},
  title   = {{Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {2003},
  doi     = {10.1073/pnas.0230450100},
  pmid    = {12634421},
  url     = {https://doi.org/10.1073/pnas.0230450100}
}

@article{anderson2006-16847063,
  author  = {Anderson, J. P. and Walker, D. E. and Goldstein, J. M. and de Laat, R. and Banducci, K. and Caccavello, R. J. and Barbour, R. and Huang, J. and others},
  title   = {{Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m600933200},
  pmid    = {16847063},
  url     = {https://doi.org/10.1074/jbc.m600933200}
}

@article{park2023-37081148,
  author  = {Park, M. D. and Reyes-Torres, I. and LeBerichel, J. and Hamon, P. and LaMarche, N. M. and Hegde, S. and Belabed, M. and Troncoso, L. and others},
  title   = {{TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-023-01475-4},
  pmid    = {37081148},
  url     = {https://doi.org/10.1038/s41590-023-01475-4}
}

@article{margeta2022-35977543,
  author  = {Margeta, M. A. and Yin, Z. and Madore, C. and Pitts, K. M. and Letcher, S. M. and Tang, J. and Jiang, S. and Gauthier, C. D. and others},
  title   = {{Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma}},
  journal = {Immunity},
  year    = {2022},
  doi     = {10.1016/j.immuni.2022.07.014},
  pmid    = {35977543},
  url     = {https://doi.org/10.1016/j.immuni.2022.07.014}
}

@article{replogle2015-25545807,
  author  = {Replogle, J. M. and Chan, G. and White, C. C. and Raj, T. and Winn, P. A. and Evans, D. A. and Sperling, R. A. and Chibnik, L. B. and others},
  title   = {{A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24337},
  pmid    = {25545807},
  url     = {https://doi.org/10.1002/ana.24337}
}

@article{lemere1996-8837617,
  author  = {Lemere, C. A. and Lopera, F. and Kosik, K. S. and Lendon, C. L. and Ossa, J. and Saido, T. C. and Yamaguchi, H. and Ruiz, A. and others},
  title   = {{The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology}},
  journal = {Nature medicine},
  year    = {1996},
  doi     = {10.1038/nm1096-1146},
  pmid    = {8837617},
  url     = {https://doi.org/10.1038/nm1096-1146}
}

@article{jun2017-28183528,
  author  = {Jun, G. R. and Chung, J. and Mez, J. and Barber, R. and Beecham, G. W. and Bennett, D. A. and Buxbaum, J. D. and Byrd, G. S. and others},
  title   = {{Transethnic genome-wide scan identifies novel Alzheimer's disease loci}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.12.012},
  pmid    = {28183528},
  url     = {https://doi.org/10.1016/j.jalz.2016.12.012}
}

@article{bennett2009-19398704,
  author  = {Bennett, D. A. and De Jager, P. L. and Leurgans, S. E. and Schneider, J. A.},
  title   = {{Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181a2e87d},
  pmid    = {19398704},
  url     = {https://doi.org/10.1212/wnl.0b013e3181a2e87d}
}

@article{buchman2016-26819457,
  author  = {Buchman, A. S. and Yu, L. and Boyle, P. A. and Schneider, J. A. and De Jager, P. L. and Bennett, D. A.},
  title   = {{Higher brain BDNF gene expression is associated with slower cognitive decline in older adults}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000002387},
  pmid    = {26819457},
  url     = {https://doi.org/10.1212/wnl.0000000000002387}
}

@article{sabuncu2012-22169231,
  author  = {Sabuncu, M. R. and Buckner, R. L. and Smoller, J. W. and Lee, P. H. and Fischl, B. and Sperling, R. A. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects}},
  journal = {Cerebral cortex (New York, N.Y. : 1991)},
  year    = {2012},
  doi     = {10.1093/cercor/bhr348},
  pmid    = {22169231},
  url     = {https://doi.org/10.1093/cercor/bhr348}
}

@article{schultz2023-37291760,
  author  = {Schultz, S. A. and Shirzadi, Z. and Schultz, A. P. and Liu, L. and Fitzpatrick, C. D. and McDade, E. and Barthelemy, N. R. and Renton, A. and others},
  title   = {{Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease}},
  journal = {Aging cell},
  year    = {2023},
  doi     = {10.1111/acel.13871},
  pmid    = {37291760},
  url     = {https://doi.org/10.1111/acel.13871}
}

@article{gotzl2019-31122931,
  author  = {Götzl, J. K. and Brendel, M. and Werner, G. and Parhizkar, S. and Sebastian Monasor, L. and Kleinberger, G. and Colombo, A. V. and Deussing, M. and others},
  title   = {{Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism}},
  journal = {EMBO molecular medicine},
  year    = {2019},
  doi     = {10.15252/emmm.201809711},
  pmid    = {31122931},
  url     = {https://doi.org/10.15252/emmm.201809711}
}

@article{varatharajah2019-30783207,
  author  = {Varatharajah, Y. and Ramanan, V. K. and Iyer, R. and Vemuri, P. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-38793-3},
  pmid    = {30783207},
  url     = {https://doi.org/10.1038/s41598-019-38793-3}
}

@article{daniels2026-41709913,
  author  = {Daniels, Alisha J. and McDade, Eric and Llibre‐Guerra, Jorge J. and Xiong, Chengjie and Perrin, Richard J. and Ibáñez, Laura and Supnet‐Bell, Charlene and Cruchaga, Carlos C and others},
  title   = {{15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN}},
  journal = {npj Dementia},
  year    = {2026},
  doi     = {10.1038/s44400-025-00047-7},
  pmid    = {41709913},
  url     = {https://doi.org/10.1038/s44400-025-00047-7}
}

@article{shen2007-17197420,
  author  = {Shen, J. and Kelleher, R. J.},
  title   = {{The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2007},
  doi     = {10.1073/pnas.0608332104},
  pmid    = {17197420},
  url     = {https://doi.org/10.1073/pnas.0608332104}
}

@article{rogers1999-10037734,
  author  = {Rogers, J. T. and Leiter, L. M. and McPhee, J. and Cahill, C. M. and Zhan, S. S. and Potter, H. and Nilsson, L. N.},
  title   = {{Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences}},
  journal = {The Journal of biological chemistry},
  year    = {1999},
  doi     = {10.1074/jbc.274.10.6421},
  pmid    = {10037734},
  url     = {https://doi.org/10.1074/jbc.274.10.6421}
}

@article{mendez2025-41518606,
  author  = {Mendez, Brahyan J. Galindo and Teng, Ling and Marshall, Gad A. and Liu, Lei and Chhatwal, Jasmeer P. and Hohman, Timothy J. and Mayeux, Richard P and De Jager, Philip L. and others},
  title   = {{Microglia‐specific Alzheimer's disease polygenic risk score predicts longitudinal increase in plasma tau and faster cognitive decline in cognitively unimpaired older adults}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_106441},
  pmid    = {41518606},
  url     = {https://doi.org/10.1002/alz70856_106441}
}

@article{wells2019-31564434,
  author  = {Wells, H. R. R. and Freidin, M. B. and Zainul Abidin, F. N. and Payton, A. and Dawes, P. and Munro, K. J. and Morton, C. C. and Moore, D. R. and others},
  title   = {{GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank}},
  journal = {American journal of human genetics},
  year    = {2019},
  doi     = {10.1016/j.ajhg.2019.09.008},
  pmid    = {31564434},
  url     = {https://doi.org/10.1016/j.ajhg.2019.09.008}
}

@article{xia1997-9223340,
  author  = {Xia, W. and Zhang, J. and Perez, R. and Koo, E. H. and Selkoe, D. J.},
  title   = {{Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.15.8208},
  pmid    = {9223340},
  url     = {https://doi.org/10.1073/pnas.94.15.8208}
}

@article{hemming2007-17760499,
  author  = {Hemming, M. L. and Patterson, M. and Reske-Nielsen, C. and Lin, L. and Isacson, O. and Selkoe, D. J.},
  title   = {{Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease}},
  journal = {PLoS medicine},
  year    = {2007},
  doi     = {10.1371/journal.pmed.0040262},
  pmid    = {17760499},
  url     = {https://doi.org/10.1371/journal.pmed.0040262}
}

@article{terzioglu2023-38017562,
  author  = {Terzioglu, G. and Young-Pearse, T. L.},
  title   = {{Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00674-9},
  pmid    = {38017562},
  url     = {https://doi.org/10.1186/s13024-023-00674-9}
}

@article{mendez2026-41920173,
  author  = {Mendez, Joel Sanchez and Queme, Bryan and Fu, Yubo and Morrison, John L. and Lewinger, Juan Pablo and Kawaguchi, Eric S. and Mi, Huaiyu and Obón‐Santacana, Mireia and others},
  title   = {{TGF-β Pathway–Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method}},
  journal = {Cancer Epidemiology Biomarkers \& Prevention},
  year    = {2026},
  doi     = {10.1158/1055-9965.epi-25-1754},
  pmid    = {41920173},
  url     = {https://doi.org/10.1158/1055-9965.epi-25-1754}
}

@article{baril2022-34310026,
  author  = {Baril, A. A. and Beiser, A. S. and Sanchez, E. and Mysliwiec, V. and Redline, S. and Gottlieb, D. J. and O'Connor, G. T. and Gonzales, M. M. and others},
  title   = {{Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12405},
  pmid    = {34310026},
  url     = {https://doi.org/10.1002/alz.12405}
}

@article{torre2025-39863251,
  author  = {Torre, Matthew and Zanella, Camila A. and Feany, Mel Β.},
  title   = {{The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and Alzheimer Disease}},
  journal = {American Journal Of Pathology},
  year    = {2025},
  doi     = {10.1016/j.ajpath.2024.12.013},
  pmid    = {39863251},
  url     = {https://doi.org/10.1016/j.ajpath.2024.12.013}
}

@article{moro2012-23143229,
  author  = {Moro, M. L. and Giaccone, G. and Lombardi, R. and Indaco, A. and Uggetti, A. and Morbin, M. and Saccucci, S. and Di Fede, G. and others},
  title   = {{APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38}},
  journal = {Acta neuropathologica},
  year    = {2012},
  doi     = {10.1007/s00401-012-1061-x},
  pmid    = {23143229},
  url     = {https://doi.org/10.1007/s00401-012-1061-x}
}

@article{kim2026-42234953,
  author  = {Kim, Daeeun and McInerney, Katelyn and Dagli, Chaitali S. and Armstrong, Nicole D. and Cushman, Mary and Bennett, Aleena and Blue, Elizabeth E. and Sofer, Tamar and others},
  title   = {{Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000218163},
  pmid    = {42234953},
  url     = {https://doi.org/10.1212/wnl.0000000000218163}
}

@article{kurniansyah2025-41434242,
  author  = {Kurniansyah, Nuzulul and Tasaki, Shinya and Zhu, Congcong and Farrell, John Joseph and Rehman, Habbiburr and Sherva, Richard and Hauger, Richard L. and Merritt, Victoria C. and others},
  title   = {{Hormone replacement therapy in women and vascular risk factors modify the association of a multi‐ancestry polygenic risk score with Alzheimer disease and related traits}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70861_108536},
  pmid    = {41434242},
  url     = {https://doi.org/10.1002/alz70861_108536}
}

@article{heide2017-28318110,
  author  = {Heide, Loehlein Fier and Dmitry, Prokopenko and Julian, Hecker and Cho Michael, H. and Silverman Edwin, K. and Weiss Scott, T. and Tanzi Rudolph, E. and Christoph, Lange},
  title   = {{On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows}},
  journal = {Genetic epidemiology},
  year    = {2017},
  doi     = {10.1002/gepi.22040},
  pmid    = {28318110},
  url     = {https://doi.org/10.1002/gepi.22040}
}

@article{lin2026-2a0fe361,
  author  = {Lin, W. and Beric, A. and Wisch, J. K. and Baker, B. and Jerome, G. and Minton, M. and Preminger, S. and Stauber, J. and others},
  title   = {{Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer’s Disease}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.03.31.26349851},
  url     = {https://doi.org/10.64898/2026.03.31.26349851}
}