% alzhub.org library filter % Source: https://alzhub.org/research?score_min=67&access=free&about=genetics % 121 entries, in the order the page lists them. Built from alzhub.org's own records. % 0 entries have no readable author in the source record and carry no author field. @article{fang2025-39806070, author = {Fang, M. and Hu, J. and Weiss, J. and Knopman, D. S. and Albert, M. and Windham, B. G. and Walker, K. A. and Sharrett, A. R. and Gottesman, R. F. and Lutsey, P. L. and others}, title = {{Lifetime risk and projected burden of dementia}}, journal = {Nature Medicine}, year = {2025}, doi = {10.1038/s41591-024-03340-9}, pmid = {39806070}, url = {https://doi.org/10.1038/s41591-024-03340-9} } @article{salloway2014-24450891, author = {Salloway, S. and Sperling, R. and Fox, N. C. and Blennow, K. and Klunk, W. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others}, title = {{Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2014}, doi = {10.1056/nejmoa1304839}, pmid = {24450891}, url = {https://doi.org/10.1056/nejmoa1304839} } @article{kunkle2019-30820047, author = {Kunkle, B. W. and Grenier-Boley, B. and Sims, R. and Bis, J. C. and Damotte, V. and Naj, A. C. and Boland, A. and Vronskaya, M. and others}, title = {{Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing}}, journal = {Nature genetics}, year = {2019}, doi = {10.1038/s41588-019-0358-2}, pmid = {30820047}, url = {https://doi.org/10.1038/s41588-019-0358-2} } @article{guerreiro2013-23150934, author = {Guerreiro, R. and Wojtas, A. and Bras, J. and Carrasquillo, M. and Rogaeva, E. and Majounie, E. and Cruchaga, C. and Sassi, C. and others}, title = {{TREM2 variants in Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2013}, doi = {10.1056/nejmoa1211851}, pmid = {23150934}, url = {https://doi.org/10.1056/nejmoa1211851} } @article{jansen2015-25988462, author = {Jansen, W. J. and Ossenkoppele, R. and Knol, D. L. and Tijms, B. M. and Scheltens, P. and Verhey, F. R. and Visser, P. J. and {Amyloid Biomarker Study Group} and others}, title = {{Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis}}, journal = {JAMA}, year = {2015}, doi = {10.1001/jama.2015.4668}, pmid = {25988462}, url = {https://doi.org/10.1001/jama.2015.4668} } @article{belloy2023-37930705, author = {Belloy, M. E. and Andrews, S. J. and Le Guen, Y. and Cuccaro, M. and Farrer, L. A. and Napolioni, V. and Greicius, M. D.}, title = {{APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry}}, journal = {JAMA Neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3599}, pmid = {37930705}, url = {https://doi.org/10.1001/jamaneurol.2023.3599} } @article{ossenkoppele2015-25988463, author = {Ossenkoppele, R. and Jansen, W. J. and Rabinovici, G. D. and Knol, D. L. and van der Flier, W. M. and van Berckel, B. N. and Scheltens, P. and Visser, P. J. and others}, title = {{Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis}}, journal = {JAMA}, year = {2015}, doi = {10.1001/jama.2015.4669}, pmid = {25988463}, url = {https://doi.org/10.1001/jama.2015.4669} } @article{naj2011-21460841, author = {Naj, A. C. and Jun, G. and Beecham, G. W. and Wang, L. S. and Vardarajan, B. N. and Buros, J. and Gallins, P. J. and Buxbaum, J. D. and others}, title = {{Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease}}, journal = {Nature genetics}, year = {2011}, doi = {10.1038/ng.801}, pmid = {21460841}, url = {https://doi.org/10.1038/ng.801} } @article{sims2017-28714976, author = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others}, title = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}}, journal = {Nature genetics}, year = {2017}, doi = {10.1038/ng.3916}, pmid = {28714976}, url = {https://doi.org/10.1038/ng.3916} } @article{marioni2018-29777097, author = {Marioni, R. E. and Harris, S. E. and Zhang, Q. and McRae, A. F. and Hagenaars, S. P. and Hill, W. D. and Davies, G. and Ritchie, C. W. and others}, title = {{GWAS on family history of Alzheimer's disease}}, journal = {Translational psychiatry}, year = {2018}, doi = {10.1038/s41398-018-0150-6}, pmid = {29777097}, url = {https://doi.org/10.1038/s41398-018-0150-6} } @article{wightman2021-34493870, author = {Wightman, D. P. and Jansen, I. E. and Savage, J. E. and Shadrin, A. A. and Bahrami, S. and Holland, D. and Rongve, A. and Børte, S. and others}, title = {{A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease}}, journal = {Nature genetics}, year = {2021}, doi = {10.1038/s41588-021-00921-z}, pmid = {34493870}, url = {https://doi.org/10.1038/s41588-021-00921-z} } @article{jun2016-25778476, author = {Jun, G. and Ibrahim-Verbaas, C. A. and Vronskaya, M. and Lambert, J. C. and Chung, J. and Naj, A. C. and Kunkle, B. W. and Wang, L. S. and others}, title = {{A novel Alzheimer disease locus located near the gene encoding tau protein}}, journal = {Molecular psychiatry}, year = {2016}, doi = {10.1038/mp.2015.23}, pmid = {25778476}, url = {https://doi.org/10.1038/mp.2015.23} } @article{snitz2009-20040554, author = {Snitz, B. E. and O'Meara, E. S. and Carlson, M. C. and Arnold, A. M. and Ives, D. G. and Rapp, SR. and Saxton, J. and Lopez, O. L. and others}, title = {{Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial}}, journal = {JAMA}, year = {2009}, doi = {10.1001/jama.2009.1913}, pmid = {20040554}, url = {https://doi.org/10.1001/jama.2009.1913} } @article{solomon2018-29356827, author = {Solomon, A. and Turunen, H. and Ngandu, T. and Peltonen, M. and Levälahti, E. and Helisalmi, S. and Antikainen, R. and Bäckman, L. and others}, title = {{Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2017.4365}, pmid = {29356827}, url = {https://doi.org/10.1001/jamaneurol.2017.4365} } @article{seshadri2010-20460622, author = {Seshadri, S. and Fitzpatrick, A. L. and Ikram, M. A. and DeStefano, A. L. and Gudnason, V. and Boada, M. and Bis, J. C. and Smith, A. V. and others}, title = {{Genome-wide analysis of genetic loci associated with Alzheimer disease}}, journal = {JAMA}, year = {2010}, doi = {10.1001/jama.2010.574}, pmid = {20460622}, url = {https://doi.org/10.1001/jama.2010.574} } @article{reitz2013-23571587, author = {Reitz, C. and Jun, G. and Naj, A. and Rajbhandary, R. and Vardarajan, B. N. and Wang, L. S. and Valladares, O. and Lin, C. F. and others}, title = {{Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans}}, journal = {JAMA}, year = {2013}, doi = {10.1001/jama.2013.2973}, pmid = {23571587}, url = {https://doi.org/10.1001/jama.2013.2973} } @article{kunkle2021-33074286, author = {Kunkle, B. W. and Schmidt, M. and Klein, H. U. and Naj, A. C. and Hamilton-Nelson, K. L. and Larson, E. B. and Evans, D. A. and De Jager, P. L. and others}, title = {{Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis}}, journal = {JAMA neurology}, year = {2021}, doi = {10.1001/jamaneurol.2020.3536}, pmid = {33074286}, url = {https://doi.org/10.1001/jamaneurol.2020.3536} } @article{lourida2019-31302669, author = {Lourida, I. and Hannon, E. and Littlejohns, T. J. and Langa, K. M. and Hyppönen, E. and Kuzma, E. and Llewellyn, D. J.}, title = {{Association of Lifestyle and Genetic Risk With Incidence of Dementia}}, journal = {JAMA}, year = {2019}, doi = {10.1001/jama.2019.9879}, pmid = {31302669}, url = {https://doi.org/10.1001/jama.2019.9879} } @article{ferrari2014-24943344, author = {Ferrari, R. and Hernandez, D. G. and Nalls, M. A. and Rohrer, J. D. and Ramasamy, A. and Kwok, J. B. and Dobson-Stone, C. and Brooks, W. S. and others}, title = {{Frontotemporal dementia and its subtypes: a genome-wide association study}}, journal = {The Lancet. Neurology}, year = {2014}, doi = {10.1016/s1474-4422(14)70065-1}, pmid = {24943344}, url = {https://doi.org/10.1016/s1474-4422(14)70065-1} } @article{lipnicki2019-31335910, author = {Lipnicki, D. M. and Makkar, SR. and Crawford, J. D. and Thalamuthu, A. and Kochan, N. A. and Lima-Costa, M. F. and Castro-Costa, E. and Ferri, C. P. and others}, title = {{Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study}}, journal = {PLoS medicine}, year = {2019}, doi = {10.1371/journal.pmed.1002853}, pmid = {31335910}, url = {https://doi.org/10.1371/journal.pmed.1002853} } @article{gordon2018-29397305, author = {Gordon, B. A. and Blazey, T. M. and Su, Y. and Hari-Raj, A. and Dincer, A. and Flores, S. and Christensen, J. and McDade, E. and others}, title = {{Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study}}, journal = {The Lancet. Neurology}, year = {2018}, doi = {10.1016/s1474-4422(18)30028-0}, pmid = {29397305}, url = {https://doi.org/10.1016/s1474-4422(18)30028-0} } @article{arango2021-34505386, author = {Arango, C. and Dragioti, E. and Solmi, M. and Cortese, S. and Domschke, K. and Murray, R. M. and Jones, P. B. and Uher, R. and others}, title = {{Risk and protective factors for mental disorders beyond genetics: an evidence-based atlas}}, journal = {World psychiatry : official journal of the World Psychiatric Association (WPA)}, year = {2021}, doi = {10.1002/wps.20894}, pmid = {34505386}, url = {https://doi.org/10.1002/wps.20894} } @article{sudlow2015-25826379, author = {Sudlow, Cathie L. M. and Gallacher, John and Allen, Naomi E. and Beral, Valerie and Burton, Paul Robert and Danesh, John and Downey, Paul and Elliott, Paul and others}, title = {{UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age}}, journal = {PLoS Medicine}, year = {2015}, doi = {10.1371/journal.pmed.1001779}, pmid = {25826379}, url = {https://doi.org/10.1371/journal.pmed.1001779} } @article{rajabli2025-40676597, author = {Rajabli, F. and Benchek, P. and Tosto, G. and Kushch, N. and Sha, J. and Bazemore, K. and Zhu, C. and Lee, W. P. and others}, title = {{Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease}}, journal = {Genome biology}, year = {2025}, doi = {10.1186/s13059-025-03564-z}, pmid = {40676597}, url = {https://doi.org/10.1186/s13059-025-03564-z} } @article{shcherbinin2022-36094645, author = {Shcherbinin, S. and Evans, C. D. and Lu, M. and Andersen, S. W. and Pontecorvo, M. J. and Willis, B. A. and Gueorguieva, I. and Hauck, P. M. and others}, title = {{Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.2793}, pmid = {36094645}, url = {https://doi.org/10.1001/jamaneurol.2022.2793} } @article{bergeron2018-30255971, author = {Bergeron, D. and Gorno-Tempini, M. L. and Rabinovici, G. D. and Santos-Santos, M. A. and Seeley, W. and Miller, B. L. and Pijnenburg, Y. and Keulen, M. A. and others}, title = {{Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia}}, journal = {Annals of neurology}, year = {2018}, doi = {10.1002/ana.25333}, pmid = {30255971}, url = {https://doi.org/10.1002/ana.25333} } @article{lipnicki2017-28323832, author = {Lipnicki, D. M. and Crawford, J. D. and Dutta, R. and Thalamuthu, A. and Kochan, N. A. and Andrews, G. and Lima-Costa, M. F. and Castro-Costa, E. and others}, title = {{Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study}}, journal = {PLoS medicine}, year = {2017}, doi = {10.1371/journal.pmed.1002261}, pmid = {28323832}, url = {https://doi.org/10.1371/journal.pmed.1002261} } @article{xu2025-40067298, author = {Xu, X. and Kwon, J. and Yan, R. and Apio, C. and Song, S. and Heo, G. and Yang, Q. and Timsina, J. and others}, title = {{Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries}}, journal = {JAMA network open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.0562}, pmid = {40067298}, url = {https://doi.org/10.1001/jamanetworkopen.2025.0562} } @article{ryman2014-24928124, author = {Ryman, D. C. and Acosta-Baena, N. and Aisen, P. S. and Bird, T. and Danek, A. and Fox, N. C. and Goate, A. and Frommelt, P. and others}, title = {{Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000596}, pmid = {24928124}, url = {https://doi.org/10.1212/wnl.0000000000000596} } @article{fornage2011-21681796, author = {Fornage, M. and Debette, S. and Bis, J. C. and Schmidt, H. and Ikram, M. A. and Dufouil, C. and Sigurdsson, S. and Lumley, T. and others}, title = {{Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22403}, pmid = {21681796}, url = {https://doi.org/10.1002/ana.22403} } @article{sherva2023-36543923, author = {Sherva, R. and Zhang, R. and Sahelijo, N. and Jun, G. and Anglin, T. and Chanfreau, C. and Cho, K. and Fonda, JR. and others}, title = {{African ancestry GWAS of dementia in a large military cohort identifies significant risk loci}}, journal = {Molecular psychiatry}, year = {2023}, doi = {10.1038/s41380-022-01890-3}, pmid = {36543923}, url = {https://doi.org/10.1038/s41380-022-01890-3} } @article{li2016-26001840, author = {Li, J. Q. and Tan, L. and Wang, H. F. and Tan, M. S. and Xu, W. and Zhao, Q. F. and Wang, J. and others}, title = {{Risk factors for predicting progression from mild cognitive impairment to Alzheimer's disease: a systematic review and meta-analysis of cohort studies}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2016}, doi = {10.1136/jnnp-2014-310095}, pmid = {26001840}, url = {https://doi.org/10.1136/jnnp-2014-310095} } @article{lill2015-25936935, author = {Lill, C. M. and Rengmark, A. and Pihlstrøm, L. and Fogh, I. and Shatunov, A. and Sleiman, P. M. and Wang, L. S. and Liu, T. and others}, title = {{The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2014.12.009}, pmid = {25936935}, url = {https://doi.org/10.1016/j.jalz.2014.12.009} } @article{pottier2025-40280976, author = {Pottier, Cyril P. and Küçükali, Fahri and Baker, Matt C. and Batzler, Anthony and Jenkins, Gregory D. and van Blitterswijk, Marka and Vicente, Cristina T. and De Coster, Wouter and others}, title = {{Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing}}, journal = {Nature Communications}, year = {2025}, doi = {10.1038/s41467-025-59216-0}, pmid = {40280976}, url = {https://doi.org/10.1038/s41467-025-59216-0} } @article{altmann2014-24623176, author = {Altmann, A. and Tian, L. and Henderson, V. W. and Greicius, M. D. and {Alzheimer's Disease Neuroimaging Initiative Investigators}}, title = {{Sex modifies the APOE-related risk of developing Alzheimer disease}}, journal = {Annals of neurology}, year = {2014}, doi = {10.1002/ana.24135}, pmid = {24623176}, url = {https://doi.org/10.1002/ana.24135} } @article{neu2017-28846757, author = {Neu, S. C. and Pa, J. and Kukull, W. and Beekly, D. and Kuzma, A. and Gangadharan, P. and Wang, L. S. and Romero, K. and others}, title = {{Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.2188}, pmid = {28846757}, url = {https://doi.org/10.1001/jamaneurol.2017.2188} } @article{ferreira2020-32047067, author = {Ferreira, D. and Nordberg, A. and Westman, E.}, title = {{Biological subtypes of Alzheimer disease: A systematic review and meta-analysis}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009058}, pmid = {32047067}, url = {https://doi.org/10.1212/wnl.0000000000009058} } @article{jonsson2013-23150908, author = {Jonsson, T. and Stefansson, H. and Steinberg, S. and Jonsdottir, I. and Jonsson, P. V. and Snaedal, J. and Bjornsson, S. and Huttenlocher, J. and others}, title = {{Variant of TREM2 associated with the risk of Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2013}, doi = {10.1056/nejmoa1211103}, pmid = {23150908}, url = {https://doi.org/10.1056/nejmoa1211103} } @article{rojas2021-33827960, author = {Rojas, J. C. and Wang, P. and Staffaroni, A. M. and Heller, C. and Cobigo, Y. and Wolf, A. and Goh, S. M. and Ljubenkov, P. A. and others}, title = {{Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011848}, pmid = {33827960}, url = {https://doi.org/10.1212/wnl.0000000000011848} } @article{shannon2023-36915130, author = {Shannon, O. M. and Ranson, J. M. and Gregory, S. and Macpherson, H. and Milte, C. and Lentjes, M. and others}, title = {{Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study}}, journal = {BMC Medicine}, year = {2023}, doi = {10.1186/s12916-023-02772-3}, pmid = {36915130}, url = {https://doi.org/10.1186/s12916-023-02772-3} } @article{leguen2023-36809323, author = {Le Guen, Y. and Raulin, A. C. and Logue, M. W. and Sherva, R. and Belloy, M. E. and Eger, S. J. and Chen, A. and Kennedy, G. and Kuchenbecker, L. and O'Leary, J. P. and Zhang, R. and Merritt, V. C. and others}, title = {{Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease}}, journal = {JAMA}, year = {2023}, doi = {10.1001/jama.2023.0268}, pmid = {36809323}, url = {https://doi.org/10.1001/jama.2023.0268} } @article{jansen2022-36066633, author = {Jansen, I. E. and van der Lee, S. J. and Gomez-Fonseca, D. and de Rojas, I. and Dalmasso, M. C. and Grenier-Boley, B. and Zettergren, A. and Mishra, A. and others}, title = {{Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers}}, journal = {Acta neuropathologica}, year = {2022}, doi = {10.1007/s00401-022-02454-z}, pmid = {36066633}, url = {https://doi.org/10.1007/s00401-022-02454-z} } @article{quiroz2024-38899694, author = {Quiroz, Y. T. and Aguillon, D. and Aguirre-Acevedo, D. C. and Vasquez, D. and Zuluaga, Y. and Baena, A. Y. and Madrigal, L. and Hincapié, L. and Sanchez, J. S. and Langella, S. and Posada-Duque, R. and Littau, J. L. and others}, title = {{APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease}}, journal = {New England Journal of Medicine}, year = {2024}, doi = {10.1056/NEJMoa2308583}, pmid = {38899694}, url = {https://doi.org/10.1056/NEJMoa2308583} } @article{bhattarai2024-38598053, author = {Bhattarai, P. and Gunasekaran, T. I. and Belloy, M. E. and Reyes-Dumeyer, D. and Jülich, D. and Tayran, H. and Yilmaz, E. and Flaherty, D. and Turgutalp, B. and Sukumar, G. and Alba, C. and McGrath, E. M. and others}, title = {{Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease}}, journal = {Acta Neuropathologica}, year = {2024}, doi = {10.1007/s00401-024-02721-1}, pmid = {38598053}, url = {https://doi.org/10.1007/s00401-024-02721-1} } @article{salvado2025-40952756, author = {Salvadó, G. and Janelidze, S. and Bali, D. and Dolado, A. O. and Therriault, J. and Brum, W. S. and Pichet Binette, A. and Stomrud, E. and Mattsson-Carlgren, N. and Palmqvist, S. and Coomans, E. M. and Teunissen, C. E. and others}, title = {{Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.3217}, pmid = {40952756}, url = {https://doi.org/10.1001/jamaneurol.2025.3217} } @article{landau2010-20592257, author = {Landau, S. M. and Harvey, D. and Madison, C. M. and Reiman, E. M. and Foster, N. L. and Aisen, P. S. and Petersen, R. C. and Shaw, L. M. and others}, title = {{Comparing predictors of conversion and decline in mild cognitive impairment}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181e8e8b8}, pmid = {20592257}, url = {https://doi.org/10.1212/wnl.0b013e3181e8e8b8} } @article{chapuis2013-23399914, author = {Chapuis, J. and Hansmannel, F. and Gistelinck, M. and Mounier, A. and Van Cauwenberghe, C. and Kolen, K. V. and Geller, F. and Sottejeau, Y. and others}, title = {{Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology}}, journal = {Molecular psychiatry}, year = {2013}, doi = {10.1038/mp.2013.1}, pmid = {23399914}, url = {https://doi.org/10.1038/mp.2013.1} } @article{naj2014-25199842, author = {Naj, A. C. and Jun, G. and Reitz, C. and Kunkle, B. W. and Perry, W. and Park, Y. S. and Beecham, G. W. and Rajbhandary, R. A. and others}, title = {{Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.1491}, pmid = {25199842}, url = {https://doi.org/10.1001/jamaneurol.2014.1491} } @article{fleisher2011-21917762, author = {Fleisher, A. S. and Truran, D. and Mai, J. T. and Langbaum, J. B. and Aisen, P. S. and Cummings, J. L. and Jack, C. R. and Weiner, M. W. and others}, title = {{Chronic divalproex sodium use and brain atrophy in Alzheimer disease}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e318230a16c}, pmid = {21917762}, url = {https://doi.org/10.1212/wnl.0b013e318230a16c} } @article{hampel2020-32296418, author = {Hampel, H. and Caraci, F. and Cuello, A. C. and Caruso, G. and Nisticò, R. and Corbo, M. and Baldacci, F. and Toschi, N. and others}, title = {{A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease}}, journal = {Frontiers in immunology}, year = {2020}, doi = {10.3389/fimmu.2020.00456}, pmid = {32296418}, url = {https://doi.org/10.3389/fimmu.2020.00456} } @article{nelson2014-24770881, author = {Nelson, P. T. and Estus, S. and Abner, E. L. and Parikh, I. and Malik, M. and Neltner, J. H. and Ighodaro, E. and Wang, W. X. and others}, title = {{ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology}}, journal = {Acta neuropathologica}, year = {2014}, doi = {10.1007/s00401-014-1282-2}, pmid = {24770881}, url = {https://doi.org/10.1007/s00401-014-1282-2} } @article{hohman2018-29801024, author = {Hohman, T. J. and Dumitrescu, L. and Barnes, L. L. and Thambisetty, M. and Beecham, G. and Kunkle, B. and Gifford, K. A. and Bush, W. S. and others}, title = {{Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2018.0821}, pmid = {29801024}, url = {https://doi.org/10.1001/jamaneurol.2018.0821} } @article{kern2018-29653987, author = {Kern, S. and Zetterberg, H. and Kern, J. and Zettergren, A. and Waern, M. and Höglund, K. and Andreasson, U. and Wetterberg, H. and others}, title = {{Prevalence of preclinical Alzheimer disease: Comparison of current classification systems}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005476}, pmid = {29653987}, url = {https://doi.org/10.1212/wnl.0000000000005476} } @article{nalls2013-23588557, author = {Nalls, M. A. and Duran, R. and Lopez, G. and Kurzawa-Akanbi, M. and McKeith, I. G. and Chinnery, P. F. and Morris, C. M. and Theuns, J. and others}, title = {{A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.1925}, pmid = {23588557}, url = {https://doi.org/10.1001/jamaneurol.2013.1925} } @article{morenasrodriguez2022-35305339, author = {Morenas-Rodríguez, E. and Li, Y. and Nuscher, B. and Franzmeier, N. and Xiong, C. and Suárez-Calvet, M. and Fagan, A. M. and Schultz, S. and others}, title = {{Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study}}, journal = {The Lancet. Neurology}, year = {2022}, doi = {10.1016/s1474-4422(22)00027-8}, pmid = {35305339}, url = {https://doi.org/10.1016/s1474-4422(22)00027-8} } @article{johnson2018-29322089, author = {Johnson, S. C. and Koscik, R. L. and Jonaitis, E. M. and Clark, L. R. and Mueller, K. D. and Berman, S. E. and Bendlin, B. B. and Engelman, C. D. and others}, title = {{The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2018}, doi = {10.1016/j.dadm.2017.11.007}, pmid = {29322089}, url = {https://doi.org/10.1016/j.dadm.2017.11.007} } @article{parhizkar2019-30617257, author = {Parhizkar, S. and Arzberger, T. and Brendel, M. and Kleinberger, G. and Deussing, M. and Focke, C. and Nuscher, B. and Xiong, M. and others}, title = {{Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-018-0296-9}, pmid = {30617257}, url = {https://doi.org/10.1038/s41593-018-0296-9} } @article{long2024-39444037, author = {Long, H. and Simmons, A. and Mayorga, A. and Burgess, B. and Nguyen, T. and Budda, B. and Rychkova, A. and Rhinn, H. and others}, title = {{Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01599-1}, pmid = {39444037}, url = {https://doi.org/10.1186/s13195-024-01599-1} } @article{armstrong2020-32517579, author = {Armstrong, N. J. and Mather, K. A. and Sargurupremraj, M. and Knol, M. J. and Malik, R. and Satizabal, C. L. and Yanek, L. R. and Wen, W. and others}, title = {{Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities}}, journal = {Stroke}, year = {2020}, doi = {10.1161/strokeaha.119.027544}, pmid = {32517579}, url = {https://doi.org/10.1161/strokeaha.119.027544} } @article{wolters2019-31356640, author = {Wolters, F. J. and Yang, Q. and Biggs, M. L. and Jakobsdottir, J. and Li, S. and Evans, D. S. and Bis, J. C. and Harris, T. B. and others}, title = {{The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)}}, journal = {PloS one}, year = {2019}, doi = {10.1371/journal.pone.0219668}, pmid = {31356640}, url = {https://doi.org/10.1371/journal.pone.0219668} } @article{roostaei2017-27021820, author = {Roostaei, T. and Nazeri, A. and Felsky, D. and De Jager, P. L. and Schneider, J. A. and Pollock, B. G. and Bennett, D. A. and Voineskos, A. N. and others}, title = {{Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease}}, journal = {Molecular psychiatry}, year = {2017}, doi = {10.1038/mp.2016.35}, pmid = {27021820}, url = {https://doi.org/10.1038/mp.2016.35} } @article{sevigny2024-38745011, author = {Sevigny, J. and Uspenskaya, O. and Heckman, L. D. and Wong, L. C. and Hatch, D. A. and Tewari, A. and Vandenberghe, R. and Irwin, D. J. and others}, title = {{Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-02973-0}, pmid = {38745011}, url = {https://doi.org/10.1038/s41591-024-02973-0} } @article{broce2018-29315334, author = {Broce, I. and Karch, C. M. and Wen, N. and Fan, C. C. and Wang, Y. and Tan, C. H. and Kouri, N. and Ross, O. A. and others}, title = {{Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies}}, journal = {PLoS medicine}, year = {2018}, doi = {10.1371/journal.pmed.1002487}, pmid = {29315334}, url = {https://doi.org/10.1371/journal.pmed.1002487} } @article{tessier2024-38709531, author = {Tessier, A. J. and Cortese, M. and Yuan, C. and Bjornevik, K. and Ascherio, A. and Wang, D. D. and Chavarro, J. E. and Stampfer, M. J. and Hu, F. B. and Willett, W. C. and others}, title = {{Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death}}, journal = {JAMA Network Open}, year = {2024}, doi = {10.1001/jamanetworkopen.2024.10021}, pmid = {38709531}, url = {https://doi.org/10.1001/jamanetworkopen.2024.10021} } @article{sanchez2025-40063856, author = {Sanchez, E. and Coughlan, G. T. and Wilkinson, T. and Ramirez, J. and Mirza, S. S. and Baril, A. A. and Dilliott, A. A. and Frank, A. and others}, title = {{Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213438}, pmid = {40063856}, url = {https://doi.org/10.1212/wnl.0000000000213438} } @article{tang1998-9508150, author = {Tang, M. X. and Stern, Y. and Marder, K. and Bell, K. and Gurland, B. and Lantigua, R. and Andrews, H. and Feng, L. and others}, title = {{The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics}}, journal = {JAMA}, year = {1998}, doi = {10.1001/jama.279.10.751}, pmid = {9508150}, url = {https://doi.org/10.1001/jama.279.10.751} } @article{sargurupremraj2020-33293549, author = {Sargurupremraj, M. and Suzuki, H. and Jian, X. and Sarnowski, C. and Evans, T. E. and Bis, J. C. and Eiriksdottir, G. and Sakaue, S. and others}, title = {{Cerebral small vessel disease genomics and its implications across the lifespan}}, journal = {Nature communications}, year = {2020}, doi = {10.1038/s41467-020-19111-2}, pmid = {33293549}, url = {https://doi.org/10.1038/s41467-020-19111-2} } @article{hithersay2019-30452522, author = {Hithersay, R. and Startin, C. M. and Hamburg, S. and Mok, K. Y. and Hardy, J. and Fisher, E. M. C. and Tybulewicz, V. L. J. and Nizetic, D. and others}, title = {{Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2018.3616}, pmid = {30452522}, url = {https://doi.org/10.1001/jamaneurol.2018.3616} } @article{salinas2022-35131906, author = {Salinas, J. and Beiser, A. S. and Samra, J. K. and O'Donnell, A. and DeCarli, C. S. and Gonzales, M. M. and Aparicio, H. J. and Seshadri, S.}, title = {{Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200039}, pmid = {35131906}, url = {https://doi.org/10.1212/wnl.0000000000200039} } @article{ritchie2010-20688841, author = {Ritchie, K. and Carrière, I. and Ritchie, C. W. and Berr, C. and Artero, S. and Ancelin, M. L.}, title = {{Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors}}, journal = {BMJ (Clinical research ed.)}, year = {2010}, doi = {10.1136/bmj.c3885}, pmid = {20688841}, url = {https://doi.org/10.1136/bmj.c3885} } @article{dube2019-31591557, author = {Dube, U. and Del-Aguila, J. L. and Li, Z. and Budde, J. P. and Jiang, S. and Hsu, S. and Ibanez, L. and Fernandez, M. V. and others}, title = {{An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations}}, journal = {Nature neuroscience}, year = {2019}, doi = {10.1038/s41593-019-0501-5}, pmid = {31591557}, url = {https://doi.org/10.1038/s41593-019-0501-5} } @article{mirza2019-31575706, author = {Mirza, S. S. and Saeed, U. and Knight, J. and Ramirez, J. and Stuss, D. T. and Keith, J. and Nestor, S. M. and Yu, D. and others}, title = {{APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia}}, journal = {Neurology}, year = {2019}, doi = {10.1212/wnl.0000000000008377}, pmid = {31575706}, url = {https://doi.org/10.1212/wnl.0000000000008377} } @article{marden2014-25328845, author = {Marden, JR. and Walter, S. and Tchetgen Tchetgen, E. J. and Kawachi, I. and Glymour, M. M.}, title = {{Validation of a polygenic risk score for dementia in black and white individuals}}, journal = {Brain and behavior}, year = {2014}, doi = {10.1002/brb3.248}, pmid = {25328845}, url = {https://doi.org/10.1002/brb3.248} } @article{szwedo2022-35106798, author = {Szwedo, A. A. and Dalen, I. and Pedersen, K. F. and Camacho, M. and Bäckström, D. and Forsgren, L. and Tzoulis, C. and Winder-Rhodes, S. and others}, title = {{GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2022}, doi = {10.1002/mds.28932}, pmid = {35106798}, url = {https://doi.org/10.1002/mds.28932} } @article{caselli2009-19605830, author = {Caselli, R. J. and Dueck, A. C. and Osborne, D. and Sabbagh, M. N. and Connor, D. J. and Ahern, G. L. and Baxter, L. C. and Rapcsak, S. Z. and others}, title = {{Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect}}, journal = {The New England journal of medicine}, year = {2009}, doi = {10.1056/nejmoa0809437}, pmid = {19605830}, url = {https://doi.org/10.1056/nejmoa0809437} } @article{jabbari2020-31860007, author = {Jabbari, E. and Holland, N. and Chelban, V. and Jones, P. S. and Lamb, R. and Rawlinson, C. and Guo, T. and Costantini, A. A. and others}, title = {{Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2019.4347}, pmid = {31860007}, url = {https://doi.org/10.1001/jamaneurol.2019.4347} } @article{roberts2016-26569387, author = {Roberts, R. O. and Christianson, T. J. and Kremers, W. K. and Mielke, M. M. and Machulda, M. M. and Vassilaki, M. and Alhurani, R. E. and Geda, Y. E. and others}, title = {{Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2015.2952}, pmid = {26569387}, url = {https://doi.org/10.1001/jamaneurol.2015.2952} } @article{tsuang2013-23407718, author = {Tsuang, D. and Leverenz, J. B. and Lopez, O. L. and Hamilton, R. L. and Bennett, D. A. and Schneider, J. A. and Buchman, A. S. and Larson, E. B. and others}, title = {{APOE ε4 increases risk for dementia in pure synucleinopathies}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.600}, pmid = {23407718}, url = {https://doi.org/10.1001/jamaneurol.2013.600} } @article{piccio2016-26754641, author = {Piccio, L. and Deming, Y. and Del-Águila, J. L. and Ghezzi, L. and Holtzman, D. M. and Fagan, A. M. and Fenoglio, C. and Galimberti, D. and others}, title = {{Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status}}, journal = {Acta neuropathologica}, year = {2016}, doi = {10.1007/s00401-016-1533-5}, pmid = {26754641}, url = {https://doi.org/10.1007/s00401-016-1533-5} } @article{slooter1998-9678314, author = {Slooter, A. J. and Cruts, M. and Kalmijn, S. and Hofman, A. and Breteler, M. M. and Van Broeckhoven, C. and van Duijn, C. M.}, title = {{Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study}}, journal = {Archives of neurology}, year = {1998}, doi = {10.1001/archneur.55.7.964}, pmid = {9678314}, url = {https://doi.org/10.1001/archneur.55.7.964} } @article{miyashita2013-23565137, author = {Miyashita, A. and Koike, A. and Jun, G. and Wang, L. S. and Takahashi, S. and Matsubara, E. and Kawarabayashi, T. and Shoji, M. and others}, title = {{SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians}}, journal = {PloS one}, year = {2013}, doi = {10.1371/journal.pone.0058618}, pmid = {23565137}, url = {https://doi.org/10.1371/journal.pone.0058618} } @article{verhaaren2015-25663218, author = {Verhaaren, B. F. and Debette, S. and Bis, J. C. and Smith, J. A. and Ikram, M. K. and Adams, H. H. and Beecham, A. H. and Rajan, K. B. and others}, title = {{Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI}}, journal = {Circulation. Cardiovascular genetics}, year = {2015}, doi = {10.1161/circgenetics.114.000858}, pmid = {25663218}, url = {https://doi.org/10.1161/circgenetics.114.000858} } @article{chauhan2015-25670335, author = {Chauhan, G. and Adams, H. H. H. and Bis, J. C. and Weinstein, G. and Yu, L. and Töglhofer, A. M. and Smith, A. V. and van der Lee, S. J. and others}, title = {{Association of Alzheimer's disease GWAS loci with MRI markers of brain aging}}, journal = {Neurobiology of aging}, year = {2015}, doi = {10.1016/j.neurobiolaging.2014.12.028}, pmid = {25670335}, url = {https://doi.org/10.1016/j.neurobiolaging.2014.12.028} } @article{farnsworthvoncederwald2022-35444051, author = {Farnsworth von Cederwald, B. and Josefsson, M. and Wåhlin, A. and Nyberg, L. and Karalija, N.}, title = {{Association of Cardiovascular Risk Trajectory With Cognitive Decline and Incident Dementia}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200255}, pmid = {35444051}, url = {https://doi.org/10.1212/wnl.0000000000200255} } @article{christensen2018-28726810, author = {Christensen, K. D. and Uhlmann, W. R. and Roberts, J. S. and Linnenbringer, E. and Whitehouse, P. J. and Royal, C. D. M. and Obisesan, T. O. and Cupples, L. A. and others}, title = {{A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone}}, journal = {Genetics in medicine : official journal of the American College of Medical Genetics}, year = {2018}, doi = {10.1038/gim.2017.103}, pmid = {28726810}, url = {https://doi.org/10.1038/gim.2017.103} } @article{gottesman2016-27371485, author = {Gottesman, R. F. and Schneider, A. L. and Zhou, Y. and Chen, X. and Green, E. and Gupta, N. and Knopman, D. S. and Mintz, A. and others}, title = {{The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE}}, journal = {Neurology}, year = {2016}, doi = {10.1212/wnl.0000000000002914}, pmid = {27371485}, url = {https://doi.org/10.1212/wnl.0000000000002914} } @article{fortea2024-38710950, author = {Fortea, J. and Pegueroles, J. and Alcolea, D. and Belbin, O. and Dols-Icardo, O. and Vaqué-Alcázar, L. and Videla, L. and Gispert, J. D. and others}, title = {{APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease}}, journal = {Nature medicine}, year = {2024}, doi = {10.1038/s41591-024-02931-w}, pmid = {38710950}, url = {https://doi.org/10.1038/s41591-024-02931-w} } @article{mccarty2011-21269473, author = {McCarty, C. A. and Chisholm, R. L. and Chute, C. G. and Kullo, I. J. and Jarvik, G. P. and Larson, E. B. and Li, R. and Masys, D. R. and others}, title = {{The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies}}, journal = {BMC medical genomics}, year = {2011}, doi = {10.1186/1755-8794-4-13}, pmid = {21269473}, url = {https://doi.org/10.1186/1755-8794-4-13} } @article{petersen2005-15829527, author = {Petersen, R. C. and Thomas, R. G. and Grundman, M. and Bennett, D. and Doody, R. and Ferris, S. and Galasko, D. and Jin, S. and others}, title = {{Vitamin E and donepezil for the treatment of mild cognitive impairment}}, journal = {The New England journal of medicine}, year = {2005}, doi = {10.1056/nejmoa050151}, pmid = {15829527}, url = {https://doi.org/10.1056/nejmoa050151} } @article{suarezcalvet2019-30630532, author = {Suárez-Calvet, M. and Morenas-Rodríguez, E. and Kleinberger, G. and Schlepckow, K. and MÁ, Araque Caballero and Franzmeier, N. and Capell, A. and Fellerer, K. and others}, title = {{Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology}}, journal = {Molecular neurodegeneration}, year = {2019}, doi = {10.1186/s13024-018-0301-5}, pmid = {30630532}, url = {https://doi.org/10.1186/s13024-018-0301-5} } @article{benitez2014-24439484, author = {Benitez, B. A. and Jin, S. C. and Guerreiro, R. and Graham, R. and Lord, J. and Harold, D. and Sims, R. and Lambert, J. C. and others}, title = {{Missense variant in TREML2 protects against Alzheimer's disease}}, journal = {Neurobiology of aging}, year = {2014}, doi = {10.1016/j.neurobiolaging.2013.12.010}, pmid = {24439484}, url = {https://doi.org/10.1016/j.neurobiolaging.2013.12.010} } @article{topiwala2026-40987604, author = {Topiwala, A. and Levey, D. F. and Zhou, H. and Deak, J. D. and Adhikari, K. and Ebmeier, K. P. and others}, title = {{Alcohol use and risk of dementia in diverse populations: evidence from cohort, case-control and Mendelian randomisation approaches}}, journal = {BMJ Evidence-Based Medicine}, year = {2026}, doi = {10.1136/bmjebm-2025-113913}, pmid = {40987604}, url = {https://doi.org/10.1136/bmjebm-2025-113913} } @article{sperling2020-32250387, author = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Sun, C. K. and Yaari, R. and Holdridge, K. and Siemers, E. and Johnson, K. A. and others}, title = {{Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.0387}, pmid = {32250387}, url = {https://doi.org/10.1001/jamaneurol.2020.0387} } @article{therriault2021-33443136, author = {Therriault, J. and Pascoal, T. A. and Benedet, A. L. and Tissot, C. and Savard, M. and Chamoun, M. and Lussier, F. and Kang, M. S. and others}, title = {{Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000011416}, pmid = {33443136}, url = {https://doi.org/10.1212/wnl.0000000000011416} } @article{yu2015-25365775, author = {Yu, L. and Chibnik, L. B. and Srivastava, G. P. and Pochet, N. and Yang, J. and Xu, J. and Kozubek, J. and Obholzer, N. and others}, title = {{Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2014.3049}, pmid = {25365775}, url = {https://doi.org/10.1001/jamaneurol.2014.3049} } @article{szekely2008-18003940, author = {Szekely, C. A. and Breitner, J. C. and Fitzpatrick, A. L. and Rea, T. D. and Psaty, B. M. and Kuller, L. H. and Zandi, P. P.}, title = {{NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000284596.95156.48}, pmid = {18003940}, url = {https://doi.org/10.1212/01.wnl.0000284596.95156.48} } @article{bernath2020-32358220, author = {Bernath, M. M. and Bhattacharyya, S. and Nho, K. and Barupal, D. K. and Fiehn, O. and Baillie, R. and Risacher, S. L. and Arnold, M. and others}, title = {{Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009436}, pmid = {32358220}, url = {https://doi.org/10.1212/wnl.0000000000009436} } @article{bettens2012-22248099, author = {Bettens, K. and Brouwers, N. and Engelborghs, S. and Lambert, J. C. and Rogaeva, E. and Vandenberghe, R. and Le Bastard, N. and Pasquier, F. and others}, title = {{Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk}}, journal = {Molecular neurodegeneration}, year = {2012}, doi = {10.1186/1750-1326-7-3}, pmid = {22248099}, url = {https://doi.org/10.1186/1750-1326-7-3} } @article{irwin2017-27979356, author = {Irwin, D. J. and Grossman, M. and Weintraub, D. and Hurtig, H. I. and Duda, J. E. and Xie, S. X. and Lee, E. B. and Van Deerlin, V. M. and others}, title = {{Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis}}, journal = {The Lancet. Neurology}, year = {2017}, doi = {10.1016/s1474-4422(16)30291-5}, pmid = {27979356}, url = {https://doi.org/10.1016/s1474-4422(16)30291-5} } @article{holstege2022-36411364, author = {Holstege, H. and Hulsman, M. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Grozeva, D. and van Rooij, J. G. J. and Sims, R. and others}, title = {{Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease}}, journal = {Nature genetics}, year = {2022}, doi = {10.1038/s41588-022-01208-7}, pmid = {36411364}, url = {https://doi.org/10.1038/s41588-022-01208-7} } @article{hughes2013-24132374, author = {Hughes, T. M. and Kuller, L. H. and Barinas-Mitchell, E. J. and Mackey, R. H. and McDade, E. M. and Klunk, W. E. and Aizenstein, H. J. and Cohen, A. D. and others}, title = {{Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults}}, journal = {Neurology}, year = {2013}, doi = {10.1212/01.wnl.0000435301.64776.37}, pmid = {24132374}, url = {https://doi.org/10.1212/01.wnl.0000435301.64776.37} } @article{ayton2015-25988319, author = {Ayton, S. and Faux, N. G. and Bush, A. I. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE}}, journal = {Nature communications}, year = {2015}, doi = {10.1038/ncomms7760}, pmid = {25988319}, url = {https://doi.org/10.1038/ncomms7760} } @article{carrasquillo2017-27939925, author = {Carrasquillo, M. M. and Allen, M. and Burgess, J. D. and Wang, X. and Strickland, S. L. and Aryal, S. and Siuda, J. and Kachadoorian, M. L. and others}, title = {{A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2016.10.005}, pmid = {27939925}, url = {https://doi.org/10.1016/j.jalz.2016.10.005} } @article{klee2023-37085245, author = {Klee, M. and Leist, A. K. and Veldsman, M. and Ranson, J. M. and Llewellyn, D. J.}, title = {{Socioeconomic Deprivation, Genetic Risk, and Incident Dementia}}, journal = {American journal of preventive medicine}, year = {2023}, doi = {10.1016/j.amepre.2023.01.012}, pmid = {37085245}, url = {https://doi.org/10.1016/j.amepre.2023.01.012} } @article{godrich2025-41208712, author = {Godrich, Dana and Pasteris, Jeremy and Martin, Eden R. and Kunkle, Brian W. and Naj, Adam Christian and Hamilton, Kara and Wang, Hui and Lee, Wan‐Ping and others}, title = {{Genome‐wide association studies of TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70760}, pmid = {41208712}, url = {https://doi.org/10.1002/alz.70760} } @article{saadmaan2026-40747850, author = {Saadmaan, Gazi and Dalmasso, Maria Carolina and Maria, Maleeha and Lehtisalo, Jenni and Hiltunen, Mikko and Kaikkonen, Minna U and Levälahti, Esko and Mangialasche, Francesca and others}, title = {{Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial}}, journal = {Brain : a journal of neurology}, year = {2026}, doi = {10.1093/brain/awaf277}, pmid = {40747850}, url = {https://doi.org/10.1093/brain/awaf277} } @article{ossenkoppele2020-32091549, author = {Ossenkoppele, R. and Lyoo, C. H. and Jester-Broms, J. and Sudre, C. H. and Cho, H. and Ryu, Y. H. and Choi, J. Y. and Smith, R. and others}, title = {{Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2019.5154}, pmid = {32091549}, url = {https://doi.org/10.1001/jamaneurol.2019.5154} } @article{antolini2021-34531298, author = {Antolini, L. and DiFrancesco, J. C. and Zedde, M. and Basso, G. and Arighi, A. and Shima, A. and Cagnin, A. and Caulo, M. and others}, title = {{Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012778}, pmid = {34531298}, url = {https://doi.org/10.1212/wnl.0000000000012778} } @article{vanrossum2012-23019259, author = {van Rossum, I. A. and Vos, S. J. and Burns, L. and Knol, D. L. and Scheltens, P. and Soininen, H. and Wahlund, L. O. and Hampel, H. and others}, title = {{Injury markers predict time to dementia in subjects with MCI and amyloid pathology}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182704056}, pmid = {23019259}, url = {https://doi.org/10.1212/wnl.0b013e3182704056} } @article{dourlen2017-27113998, author = {Dourlen, P. and Fernandez-Gomez, F. J. and Dupont, C. and Grenier-Boley, B. and Bellenguez, C. and Obriot, H. and Caillierez, R. and Sottejeau, Y. and others}, title = {{Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology}}, journal = {Molecular psychiatry}, year = {2017}, doi = {10.1038/mp.2016.59}, pmid = {27113998}, url = {https://doi.org/10.1038/mp.2016.59} } @article{hanson2013-23779114, author = {Hanson, A. J. and Bayer-Carter, J. L. and Green, P. S. and Montine, T. J. and Wilkinson, C. W. and Baker, L. D. and Watson, G. S. and Bonner, L. M. and others}, title = {{Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.396}, pmid = {23779114}, url = {https://doi.org/10.1001/jamaneurol.2013.396} } @article{leguen2022-35639372, author = {Le Guen, Y. and Belloy, M. E. and Grenier-Boley, B. and de Rojas, I. and Castillo-Morales, A. and Jansen, I. and Nicolas, A. and Bellenguez, C. and others}, title = {{Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.1166}, pmid = {35639372}, url = {https://doi.org/10.1001/jamaneurol.2022.1166} } @article{wetmore2024-39748836, author = {Wetmore, J. B. and Rodriguez, S. and Diaz Caro, D. and Cabán, M. and Uhlmann, W. and Goldman, J. and Leu, C. S. and Godinez, J. D. and others}, title = {{Designing and implementing the IDEAL Study: A randomized clinical trial of APOE genotype disclosure for late-onset Alzheimer's disease in an urban Latino population}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2024}, doi = {10.1002/trc2.70016}, pmid = {39748836}, url = {https://doi.org/10.1002/trc2.70016} } @article{betthauser2022-35856240, author = {Betthauser, T. J. and Bilgel, M. and Koscik, R. L. and Jedynak, B. M. and An, Y. and Kellett, K. A. and Moghekar, A. and Jonaitis, E. M. and others}, title = {{Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts}}, journal = {Brain : a journal of neurology}, year = {2022}, doi = {10.1093/brain/awac213}, pmid = {35856240}, url = {https://doi.org/10.1093/brain/awac213} } @article{shirzadi2023-37843849, author = {Shirzadi, Z. and Schultz, S. A. and Yau, W. W. and Joseph-Mathurin, N. and Fitzpatrick, C. D. and Levin, R. and Kantarci, K. and Preboske, G. M. and others}, title = {{Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.3618}, pmid = {37843849}, url = {https://doi.org/10.1001/jamaneurol.2023.3618} } @article{morenograu2019-31473137, author = {Moreno-Grau, S. and de Rojas, I. and Hernández, I. and Quintela, I. and Montrreal, L. and Alegret, M. and Hernández-Olasagarre, B. and Madrid, L. and others}, title = {{Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.06.4950}, pmid = {31473137}, url = {https://doi.org/10.1016/j.jalz.2019.06.4950} } @article{majounie2012-22406228, author = {Majounie, E. and Renton, A. E. and Mok, K. and Dopper, E. G. and Waite, A. and Rollinson, S. and Chiò, A. and Restagno, G. and others}, title = {{Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study}}, journal = {The Lancet. Neurology}, year = {2012}, doi = {10.1016/s1474-4422(12)70043-1}, pmid = {22406228}, url = {https://doi.org/10.1016/s1474-4422(12)70043-1} } @article{eliassonnenschein2011-21493755, author = {Elias-Sonnenschein, L. S. and Viechtbauer, W. and Ramakers, I. H. and Verhey, F. R. and Visser, P. J.}, title = {{Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2011}, doi = {10.1136/jnnp.2010.231555}, pmid = {21493755}, url = {https://doi.org/10.1136/jnnp.2010.231555} } @article{jin2015-25886450, author = {Jin, S. C. and Carrasquillo, M. M. and Benitez, B. A. and Skorupa, T. and Carrell, D. and Patel, D. and Lincoln, S. and Krishnan, S. and others}, title = {{TREM2 is associated with increased risk for Alzheimer's disease in African Americans}}, journal = {Molecular neurodegeneration}, year = {2015}, doi = {10.1186/s13024-015-0016-9}, pmid = {25886450}, url = {https://doi.org/10.1186/s13024-015-0016-9} } @article{calvin2022-36125811, author = {Calvin, C. M. and Conroy, M. C. and Moore, S. F. and Kuzma, E. and Littlejohns, T. J.}, title = {{Association of Multimorbidity, Disease Clusters, and Modification by Genetic Factors With Risk of Dementia}}, journal = {JAMA network open}, year = {2022}, doi = {10.1001/jamanetworkopen.2022.32124}, pmid = {36125811}, url = {https://doi.org/10.1001/jamanetworkopen.2022.32124} } @article{jansen2019-30617256, author = {Jansen, Iris E. and Savage, Jeanne E. and Watanabe, Kyoko and Bryois, Julien and Williams, Dylan M. and Steinberg, Stacy and Sealock, Julia and Karlsson, Ida and others}, title = {{Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk}}, journal = {Nature Genetics}, year = {2019}, doi = {10.1038/s41588-018-0311-9}, pmid = {30617256}, url = {https://doi.org/10.1038/s41588-018-0311-9} }