% alzhub.org library filter % Source: https://alzhub.org/research?about=early-stage % 500 entries, in the order the page lists them. Built from alzhub.org's own records. % 1 entries have no readable author in the source record and carry no author field. @article{yaari2025-40955720, author = {Yaari, Roy and Holdridge, Karen C and Williamson, Melissa and Wessels, Alette M and Shcherbinin, Sergey and Kotari, Vikas and Reiman, Eric M and Tariot, Pierre N and others}, title = {{Donanemab in preclinical Alzheimer's disease: Screening and baseline data from TRAILBLAZER-ALZ 3}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70662}, pmid = {40955720}, url = {https://doi.org/10.1002/alz.70662} } @article{reparazescudero2024-39179115, author = {Reparaz-Escudero, Imanol and Izquierdo, Mikel and Bischoff-Ferrari, Heike A and Martínez-Lage, P and de Asteasu, Mikel L Sáez}, title = {{Effect of long-term physical exercise and multidomain interventions on cognitive function and the risk of mild cognitive impairment and dementia in older adults: A systematic review with meta-analysis}}, journal = {Ageing research reviews}, year = {2024}, doi = {10.1016/j.arr.2024.102463}, pmid = {39179115}, url = {https://doi.org/10.1016/j.arr.2024.102463} } @article{garciacasares2021-34682764, author = {García-Casares, N. and Gallego Fuentes, P. and MÁ, Barbancho and López-Gigosos, R. and García-Rodríguez, A. and Gutiérrez-Bedmar, M.}, title = {{Alzheimer's Disease, Mild Cognitive Impairment and Mediterranean Diet. A Systematic Review and Dose-Response Meta-Analysis}}, journal = {Journal of clinical medicine}, year = {2021}, doi = {10.3390/jcm10204642}, pmid = {34682764}, url = {https://doi.org/10.3390/jcm10204642} } @article{kim2026-42475653, author = {Kim, Da Ae and Lee, Sun Min and Sun, Kyunghwa and Park, Ji Hyun and Park, Yoo Kyoung and Jeong, Jee Hyang and Hong, Chang Hyung and Jung, Jiwoo and others}, title = {{Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial}}, journal = {Neurology}, year = {2026}, doi = {10.1212/wnl.0000000000218297}, pmid = {42475653}, url = {https://doi.org/10.1212/wnl.0000000000218297} } @article{wei2017-29430246, author = {Wei, J. and Hu, Y. and Zhang, L. and Hao, Q. and Yang, R. and Lu, H. and Zhang, X. and Chandrasekar, E. K.}, title = {{Hearing Impairment, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Cohort Studies}}, journal = {Dementia and geriatric cognitive disorders extra}, year = {2017}, doi = {10.1159/000485178}, pmid = {29430246}, url = {https://doi.org/10.1159/000485178} } @article{tariot2026-41579901, author = {Tariot, Pierre N and Lopera, Francisco S and Ríos-Romenets, Silvia and Sink, Kaycee M and Giraldo-Chica, Margarita and Acosta-Baena, Natalia and Villegas, Gustavo and Espinosa, Alejandro and others}, title = {{Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial}}, journal = {The Lancet. Neurology}, year = {2026}, doi = {10.1016/s1474-4422(25)00426-0}, pmid = {41579901}, url = {https://doi.org/10.1016/s1474-4422(25)00426-0} } @article{chandler2019-31099860, author = {Chandler, M. J. and Locke, D. E. and Crook, J. E. and Fields, J. A. and Ball, C. T. and Phatak, V. S. and Dean, P. M. and Morris, M. and others}, title = {{Comparative Effectiveness of Behavioral Interventions on Quality of Life for Older Adults With Mild Cognitive Impairment: A Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.3016}, pmid = {31099860}, url = {https://doi.org/10.1001/jamanetworkopen.2019.3016} } @article{martens2026-42478598, author = {Martens, Christopher R and Decker, Kevin P and DeConne, Theodore M and Sanjana, Faria and Horvat, Fiona and Rizzi, Nicholas A and Awad, Catherine and Habash, Elizabeth and others}, title = {{A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71605}, pmid = {42478598}, url = {https://doi.org/10.1002/alz.71605} } @article{egan2019-30970186, author = {Egan, M. F. and Kost, J. and Voss, T. and Mukai, Y. and Aisen, P. S. and Cummings, J. L. and Tariot, P. N. and Vellas, B. and others}, title = {{Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease}}, journal = {The New England journal of medicine}, year = {2019}, doi = {10.1056/nejmoa1812840}, pmid = {30970186}, url = {https://doi.org/10.1056/nejmoa1812840} } @article{monteroodasso2023-37471089, author = {Montero-Odasso, M. and Zou, G. and Speechley, M. and Almeida, Q. J. and Liu-Ambrose, T. and Middleton, L. E. and Camicioli, R. and Bray, N. W. and others}, title = {{Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2023}, doi = {10.1001/jamanetworkopen.2023.24465}, pmid = {37471089}, url = {https://doi.org/10.1001/jamanetworkopen.2023.24465} } @article{chan2024-38172429, author = {Chan, A. T. C. and Ip, R. T. F. and Tran, J. Y. S. and Chan, J. Y. C. and Tsoi, K. K. F.}, title = {{Computerized cognitive training for memory functions in mild cognitive impairment or dementia: a systematic review and meta-analysis}}, journal = {NPJ digital medicine}, year = {2024}, doi = {10.1038/s41746-023-00987-5}, pmid = {38172429}, url = {https://doi.org/10.1038/s41746-023-00987-5} } @article{liang2018-29768349, author = {Liang, J. H. and Xu, Y. and Lin, L. and Jia, R. X. and Zhang, H. B. and Hang, L.}, title = {{Comparison of multiple interventions for older adults with Alzheimer disease or mild cognitive impairment: A PRISMA-compliant network meta-analysis}}, journal = {Medicine}, year = {2018}, doi = {10.1097/md.0000000000010744}, pmid = {29768349}, url = {https://doi.org/10.1097/md.0000000000010744} } @article{dekosky2008-19017911, author = {DeKosky, S. T. and Williamson, J. D. and Fitzpatrick, A. L. and Kronmal, R. A. and Ives, D. G. and Saxton, J. A. and Lopez, O. L. and Burke, G. and others}, title = {{Ginkgo biloba for prevention of dementia: a randomized controlled trial}}, journal = {JAMA}, year = {2008}, doi = {10.1001/jama.2008.683}, pmid = {19017911}, url = {https://doi.org/10.1001/jama.2008.683} } @article{winblad2008-18322263, author = {Winblad, B. and Gauthier, S. and Scinto, L. and Feldman, H. and Wilcock, G. K. and Truyen, L. and Mayorga, A. J. and Wang, D. and others}, title = {{Safety and efficacy of galantamine in subjects with mild cognitive impairment}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000303815.69777.26}, pmid = {18322263}, url = {https://doi.org/10.1212/01.wnl.0000303815.69777.26} } @article{li2022-36301590, author = {Li, R. and Geng, J. and Yang, R. and Ge, Y. and Hesketh, T.}, title = {{Effectiveness of Computerized Cognitive Training in Delaying Cognitive Function Decline in People With Mild Cognitive Impairment: Systematic Review and Meta-analysis}}, journal = {Journal of medical Internet research}, year = {2022}, doi = {10.2196/38624}, pmid = {36301590}, url = {https://doi.org/10.2196/38624} } @article{bellaver2023-37248300, author = {Bellaver, B. and Povala, G. and Ferreira, P. C. L. and Ferrari-Souza, J. P. and Leffa, D. T. and Lussier, F. Z. and Benedet, A. L. and Ashton, N. J. and Triana-Baltzer, G. and Kolb, H. C. and Tissot, C. and Therriault, J. and others}, title = {{Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease}}, journal = {Nature Medicine}, year = {2023}, doi = {10.1038/s41591-023-02380-x}, pmid = {37248300}, url = {https://doi.org/10.1038/s41591-023-02380-x} } @article{bai2022-35977150, author = {Bai, W. and Chen, P. and Cai, H. and Zhang, Q. and Su, Z. and Cheung, T. and Jackson, T. and Sha, S. and others}, title = {{Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies}}, journal = {Age and ageing}, year = {2022}, doi = {10.1093/ageing/afac173}, pmid = {35977150}, url = {https://doi.org/10.1093/ageing/afac173} } @article{shumaker2004-15213206, author = {Shumaker, S. A. and Legault, C. and Kuller, L. and Rapp, SR. and Thal, L. and Lane, D. S. and Fillit, H. and Stefanick, M. L. and others}, title = {{Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study}}, journal = {JAMA}, year = {2004}, doi = {10.1001/jama.291.24.2947}, pmid = {15213206}, url = {https://doi.org/10.1001/jama.291.24.2947} } @article{mitchell2014-25219393, author = {Mitchell, A. J. and Beaumont, H. and Ferguson, D. and Yadegarfar, M. and Stubbs, B.}, title = {{Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis}}, journal = {Acta psychiatrica Scandinavica}, year = {2014}, doi = {10.1111/acps.12336}, pmid = {25219393}, url = {https://doi.org/10.1111/acps.12336} } @article{fan2023-37519166, author = {Fan, Zhenyi and Liu, Xiaoxia and Liu, Jie and Chen, Caijing and Zhou, Min}, title = {{Neurofilament Light Chain as a Potential Biomarker in Plasma for Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and a Meta-Analysis}}, journal = {Journal of integrative neuroscience}, year = {2023}, doi = {10.31083/j.jin2204085}, pmid = {37519166}, url = {https://doi.org/10.31083/j.jin2204085} } @article{ossenkoppele2025-40155777, author = {Ossenkoppele, R. and Salvadó, G. and Janelidze, S. and Pichet Binette, A. and Bali, D. and Karlsson, L. and Palmqvist, S. and Mattsson-Carlgren, N. and Stomrud, E. and Therriault, J. and Rahmouni, N. and Rosa-Neto, P. and others}, title = {{Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials}}, journal = {Nature Aging}, year = {2025}, doi = {10.1038/s43587-025-00835-z}, pmid = {40155777}, url = {https://doi.org/10.1038/s43587-025-00835-z} } @article{yang2025-39793970, author = {Yang, Q. and Zhang, L. and Chang, F. and Yang, H. and Chen, B. and Liu, Z.}, title = {{Virtual Reality Interventions for Older Adults With Mild Cognitive Impairment: Systematic Review and Meta-Analysis of Randomized Controlled Trials}}, journal = {Journal of medical Internet research}, year = {2025}, doi = {10.2196/59195}, pmid = {39793970}, url = {https://doi.org/10.2196/59195} } @article{andrews2023-37027832, author = {Andrews, V. and Zammit, G. and O'Leary, F.}, title = {{Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews}}, journal = {Nutrition reviews}, year = {2023}, doi = {10.1093/nutrit/nuad013}, pmid = {37027832}, url = {https://doi.org/10.1093/nutrit/nuad013} } @article{sperling2023-37458272, author = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Rafii, M. S. and Johnson, K. and Masters, C. L. and van Dyck, C. H. and Iwatsubo, T. and others}, title = {{Trial of Solanezumab in Preclinical Alzheimer's Disease}}, journal = {The New England journal of medicine}, year = {2023}, doi = {10.1056/nejmoa2305032}, pmid = {37458272}, url = {https://doi.org/10.1056/nejmoa2305032} } @article{shirzadi2024-39044495, author = {Shirzadi, Z. and Schultz, A. P. and Properzi, M. and Yaari, R. and Yau, W. W. and Brickman, A. M. and Rafii, M. S. and Donohue, M. C. and others}, title = {{Greater White Matter Hyperintensity Volume Is Associated with the Number of Microhemorrhages in Preclinical Alzheimer's Disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.139}, pmid = {39044495}, url = {https://doi.org/10.14283/jpad.2024.139} } @article{silvarodriguez2026-42483984, author = {Silva-Rodríguez, Jesús and Zhang, Linda and Kleineidam, Luca and López-González, Francisco J and Wagner-Reguero, Sonia and Martínez-Castillo, Minerva and Sogorb-Esteve, Aitana and Guamán-Chulunchana, Michelle E and others}, title = {{Prognostic value of plasma \%p-tau217 in cognitively unimpaired older adults}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71599}, pmid = {42483984}, url = {https://doi.org/10.1002/alz.71599} } @article{orr2024-37994989, author = {Orr, Miranda E and Kotkowski, Eithan and Ramirez, Paulino and Bair-Kelps, Darcy and Liu, Qianqian and Brenner, Charles and Schmidt, Mark S and Fox, Peter T and others}, title = {{A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment}}, journal = {GeroScience}, year = {2024}, doi = {10.1007/s11357-023-00999-9}, pmid = {37994989}, url = {https://doi.org/10.1007/s11357-023-00999-9} } @article{cas2024-38565814, author = {Cas, A Dei and Micheli, M M and Aldigeri, R and Gardini, S and Ferrari-Pellegrini, F and Perini, M and Messa, G and Antonini, M and others}, title = {{Long-acting exenatide does not prevent cognitive decline in mild cognitive impairment: a proof-of-concept clinical trial}}, journal = {Journal of endocrinological investigation}, year = {2024}, doi = {10.1007/s40618-024-02320-7}, pmid = {38565814}, url = {https://doi.org/10.1007/s40618-024-02320-7} } @article{lyketsos2002-12243634, author = {Lyketsos, C. G. and Lopez, O. and Jones, B. and Fitzpatrick, A. L. and Breitner, J. and DeKosky, S.}, title = {{Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study}}, journal = {JAMA}, year = {2002}, doi = {10.1001/jama.288.12.1475}, pmid = {12243634}, url = {https://doi.org/10.1001/jama.288.12.1475} } @article{ostrowitzki2017-29221491, author = {Ostrowitzki, S. and Lasser, R. A. and Dorflinger, E. and Scheltens, P. and Barkhof, F. and Nikolcheva, T. and Ashford, E. and Retout, S. and others}, title = {{A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2017}, doi = {10.1186/s13195-017-0318-y}, pmid = {29221491}, url = {https://doi.org/10.1186/s13195-017-0318-y} } @article{zhang2019-31427316, author = {Zhang, H. and Huntley, J. and Bhome, R. and Holmes, B. and Cahill, J. and Gould, R. L. and Wang, H. and Yu, X. and others}, title = {{Effect of computerised cognitive training on cognitive outcomes in mild cognitive impairment: a systematic review and meta-analysis}}, journal = {BMJ open}, year = {2019}, doi = {10.1136/bmjopen-2018-027062}, pmid = {31427316}, url = {https://doi.org/10.1136/bmjopen-2018-027062} } @article{law2019-31801630, author = {Law, L. L. F. and Mok, V. C. T. and Yau, M. M. K.}, title = {{Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial}}, journal = {Alzheimer's research \& therapy}, year = {2019}, doi = {10.1186/s13195-019-0548-2}, pmid = {31801630}, url = {https://doi.org/10.1186/s13195-019-0548-2} } @article{park2021-34360490, author = {Park, E. A. and Jung, A. R. and Lee, K. A.}, title = {{The Humanoid Robot Sil-Bot in a Cognitive Training Program for Community-Dwelling Elderly People with Mild Cognitive Impairment during the COVID-19 Pandemic: A Randomized Controlled Trial}}, journal = {International journal of environmental research and public health}, year = {2021}, doi = {10.3390/ijerph18158198}, pmid = {34360490}, url = {https://doi.org/10.3390/ijerph18158198} } @article{xue2023-37769394, author = {Xue, D. and Li, P. W. C. and Yu, D. S. F. and Lin, R. S. Y.}, title = {{Combined exercise and cognitive interventions for adults with mild cognitive impairment and dementia: A systematic review and network meta-analysis}}, journal = {International journal of nursing studies}, year = {2023}, doi = {10.1016/j.ijnurstu.2023.104592}, pmid = {37769394}, url = {https://doi.org/10.1016/j.ijnurstu.2023.104592} } @article{hedden2013-23547267, author = {Hedden, T. and Oh, H. and Younger, A. P. and Patel, T. A.}, title = {{Meta-analysis of amyloid-cognition relations in cognitively normal older adults}}, journal = {Neurology}, year = {2013}, doi = {10.1212/wnl.0b013e31828ab35d}, pmid = {23547267}, url = {https://doi.org/10.1212/wnl.0b013e31828ab35d} } @article{mauti2026-183d3fda, author = {Mauti, R. and Chouk, C. and Guillot, A. and Peronin, A. and Fargier, P. and Chabaud, P.}, title = {{A clustering approach based on neuropsychological testing to detect early signs of probable MCI among community-dwelling older adults}}, journal = {Frontiers in aging neuroscience}, year = {2026}, doi = {10.64898/2026.07.04.26357270}, url = {https://doi.org/10.64898/2026.07.04.26357270} } @article{chen2022-35959295, author = {Chen, L. and Niu, X. and Wang, Y. and Lv, S. and Zhou, X. and Yang, Z. and Peng, D.}, title = {{Plasma tau proteins for the diagnosis of mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis}}, journal = {Frontiers in aging neuroscience}, year = {2022}, doi = {10.3389/fnagi.2022.942629}, pmid = {35959295}, url = {https://doi.org/10.3389/fnagi.2022.942629} } @article{palmqvist2020-32722745, author = {Palmqvist, S. and Janelidze, S. and Quiroz, Y. T. and Zetterberg, H. and Lopera, F. and Stomrud, E. and Su, Y. and Chen, Y. and others}, title = {{Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders}}, journal = {JAMA}, year = {2020}, doi = {10.1001/jama.2020.12134}, pmid = {32722745}, url = {https://doi.org/10.1001/jama.2020.12134} } @article{ossenkoppele2021-34180956, author = {Ossenkoppele, R. and Smith, R. and Mattsson-Carlgren, N. and Groot, C. and Leuzy, A. and Strandberg, O. and Palmqvist, S. and Olsson, T. and others}, title = {{Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging}}, journal = {JAMA neurology}, year = {2021}, doi = {10.1001/jamaneurol.2021.1858}, pmid = {34180956}, url = {https://doi.org/10.1001/jamaneurol.2021.1858} } @article{baker2010-20065132, author = {Baker, L. D. and Frank, L. L. and Foster-Schubert, K. and Green, P. S. and Wilkinson, C. W. and McTiernan, A. and Plymate, SR. and Fishel, M. A. and others}, title = {{Effects of aerobic exercise on mild cognitive impairment: a controlled trial}}, journal = {Archives of neurology}, year = {2010}, doi = {10.1001/archneurol.2009.307}, pmid = {20065132}, url = {https://doi.org/10.1001/archneurol.2009.307} } @article{balogun2025-41273220, author = {Balogun, Wasiu G and Zeng, Xuemei and Triana-Baltzer, Gallen and Saeed, Anum and Aigbogun, Happiness E and Gogola, Alexandra and Lopresti, Brian J and Villemagne, Victor L and others}, title = {{Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community studies}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70916}, pmid = {41273220}, url = {https://doi.org/10.1002/alz.70916} } @article{noah2020-32623211, author = {Noah, Abiodun M and Almghairbi, Dalal and Moppett, Iain K}, title = {{Optical coherence tomography in mild cognitive impairment - Systematic review and meta-analysis}}, journal = {Clinical neurology and neurosurgery}, year = {2020}, doi = {10.1016/j.clineuro.2020.106036}, pmid = {32623211}, url = {https://doi.org/10.1016/j.clineuro.2020.106036} } @article{warren2026-41568738, author = {Warren, Alison and Wynia, Zan and Corr, Patrick G and Devin, Mershad Fahim and Celikkol, Zeynep and Gordon, Lindsey and Farah, Mina and Karam, Michaela and others}, title = {{The microbiota-gut-brain axis in mild cognitive impairment and Alzheimer's disease: a scoping review of human studies}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71023}, pmid = {41568738}, url = {https://doi.org/10.1002/alz.71023} } @article{reboussin2025-d972d843, author = {Reboussin, D. M. and Gaussoin, S. A. and Pajewski, N. M. and Jaeger, B. C. and Sachs, B. and Rapp, SR. and Supiano, M. A. and Cleveland, M. L. and Hunter, V. and Demons, J. L. and Ogrocki, P. K. and Lerner, A. J. and Chelune, G. J. and Wadley, V. G. and Scales, M. L. and Woolard, N. F. and Perdue, L. H. and Callahan, K. E. and Williamson, J. D.}, title = {{Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT}}, journal = {Neurology}, year = {2025}, pmid = {39819096} } @article{nonino2026-41985900, author = {Nonino, F. and Minozzi, S. and Sambati, L. and Del Giovane, C. and Baldin, E. and Bassi, M. C. and others}, title = {{Amyloid-beta-targeting monoclonal antibodies for people with mild cognitive impairment or mild dementia due to Alzheimer's disease (Cochrane review)}}, journal = {Cochrane Database of Systematic Reviews}, year = {2026}, doi = {10.1002/14651858.CD016297}, pmid = {41985900}, url = {https://doi.org/10.1002/14651858.CD016297} } @article{rabinovici2019-30938796, author = {Rabinovici, G. D. and Gatsonis, C. and Apgar, C. and Chaudhary, K. and Gareen, I. and Hanna, L. and Hendrix, J. and Hillner, B. E. and others}, title = {{Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia}}, journal = {JAMA}, year = {2019}, doi = {10.1001/jama.2019.2000}, pmid = {30938796}, url = {https://doi.org/10.1001/jama.2019.2000} } @article{karikari2021-33106600, author = {Karikari, T. K. and Benedet, A. L. and Ashton, N. J. and Lantero Rodriguez, J. and Snellman, A. and Suárez-Calvet, M. and Saha-Chaudhuri, P. and Lussier, F. and others}, title = {{Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative}}, journal = {Molecular psychiatry}, year = {2021}, doi = {10.1038/s41380-020-00923-z}, pmid = {33106600}, url = {https://doi.org/10.1038/s41380-020-00923-z} } @article{ossenkoppele2022-36357681, author = {Ossenkoppele, R. and Pichet Binette, A. and Groot, C. and Smith, R. and Strandberg, O. and Palmqvist, S. and Stomrud, E. and Tideman, P. and others}, title = {{Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline}}, journal = {Nature medicine}, year = {2022}, doi = {10.1038/s41591-022-02049-x}, pmid = {36357681}, url = {https://doi.org/10.1038/s41591-022-02049-x} } @article{moscoso2025-40522652, author = {Moscoso, Alexis and Heeman, Fiona and Raghavan, Sheelakumari and Costoya‐Sánchez, Alejandro and van Essen, Martijn and Mainta, Ismini and Camacho, Valle and Rodríguez-Fonseca, Omar Darío and others}, title = {{Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity}}, journal = {JAMA}, year = {2025}, doi = {10.1001/jama.2025.7817}, pmid = {40522652}, url = {https://doi.org/10.1001/jama.2025.7817} } @article{chan2020-32378715, author = {Chan, J. Y. C. and Chan, T. K. and Kwok, T. C. Y. and Wong, S. Y. S. and Lee, A. T. C. and Tsoi, K. K. F.}, title = {{Cognitive training interventions and depression in mild cognitive impairment and dementia: a systematic review and meta-analysis of randomized controlled trials}}, journal = {Age and ageing}, year = {2020}, doi = {10.1093/ageing/afaa063}, pmid = {32378715}, url = {https://doi.org/10.1093/ageing/afaa063} } @article{bernini2021-32895890, author = {Bernini, S. and Panzarasa, S. and Barbieri, M. and Sinforiani, E. and Quaglini, S. and Tassorelli, C. and Bottiroli, S.}, title = {{A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool}}, journal = {Aging clinical and experimental research}, year = {2021}, doi = {10.1007/s40520-020-01665-2}, pmid = {32895890}, url = {https://doi.org/10.1007/s40520-020-01665-2} } @article{pichetbinette2022-35351181, author = {Pichet Binette, A. and Palmqvist, S. and Bali, D. and Farrar, G. and Buckley, C. J. and Wolk, D. A. and Zetterberg, H. and Blennow, K. and others}, title = {{Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer's dementia in mild cognitive impairment patients}}, journal = {Alzheimer's research \& therapy}, year = {2022}, doi = {10.1186/s13195-022-00990-0}, pmid = {35351181}, url = {https://doi.org/10.1186/s13195-022-00990-0} } @article{zhang2018-29142143, author = {Zhang, Y. P. and Lou, Y. and Hu, J. and Miao, R. and Ma, F.}, title = {{DHA supplementation improves cognitive function via enhancing Aβ-mediated autophagy in Chinese elderly with mild cognitive impairment: a randomised placebo-controlled trial}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2018}, doi = {10.1136/jnnp-2017-316176}, pmid = {29142143}, url = {https://doi.org/10.1136/jnnp-2017-316176} } @article{han2017-28587629, author = {Han, J. W. and Son, K. L. and Byun, H. J. and Ko, J. W. and Kim, K. and Hong, J. W. and Kim, T. H. and Kim, K. W.}, title = {{Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial}}, journal = {Alzheimer's research \& therapy}, year = {2017}, doi = {10.1186/s13195-017-0264-8}, pmid = {28587629}, url = {https://doi.org/10.1186/s13195-017-0264-8} } @article{cao2018-29790638, author = {Cao, B. and Rosenblat, J. D. and Brietzke, E. and Park, C. and Lee, Y. and Musial, N. and Pan, Z. and Mansur, R. B. and others}, title = {{Comparative efficacy and acceptability of antidiabetic agents for Alzheimer's disease and mild cognitive impairment: A systematic review and network meta-analysis}}, journal = {Diabetes, obesity \& metabolism}, year = {2018}, doi = {10.1111/dom.13373}, pmid = {29790638}, url = {https://doi.org/10.1111/dom.13373} } @article{janelidze2020-32123385, author = {Janelidze, S. and Mattsson, N. and Palmqvist, S. and Smith, R. and Beach, T. G. and Serrano, G. E. and Chai, X. and Proctor, N. K. and others}, title = {{Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia}}, journal = {Nature medicine}, year = {2020}, doi = {10.1038/s41591-020-0755-1}, pmid = {32123385}, url = {https://doi.org/10.1038/s41591-020-0755-1} } @article{mattsson2009-19622817, author = {Mattsson, N. and Zetterberg, H. and Hansson, O. and Andreasen, N. and Parnetti, L. and Jonsson, M. and Herukka, S. K. and van der Flier, W. M. and others}, title = {{CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment}}, journal = {JAMA}, year = {2009}, doi = {10.1001/jama.2009.1064}, pmid = {19622817}, url = {https://doi.org/10.1001/jama.2009.1064} } @article{arevalorodriguez2021-34313331, author = {Arevalo-Rodriguez, I. and Smailagic, N. and Roqué-Figuls, M. and Ciapponi, A. and Sanchez-Perez, E. and Giannakou, A. and Pedraza, O. L. and Bonfill Cosp, X. and others}, title = {{Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)}}, journal = {The Cochrane database of systematic reviews}, year = {2021}, doi = {10.1002/14651858.cd010783.pub3}, pmid = {34313331}, url = {https://doi.org/10.1002/14651858.cd010783.pub3} } @article{ward2012-22265588, author = {Ward, A. and Arrighi, H. M. and Michels, S. and Cedarbaum, J. M.}, title = {{Mild cognitive impairment: disparity of incidence and prevalence estimates}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2012}, doi = {10.1016/j.jalz.2011.01.002}, pmid = {22265588}, url = {https://doi.org/10.1016/j.jalz.2011.01.002} } @article{lu2021-33407219, author = {Lu, Y. and Liu, C. and Yu, D. and Fawkes, S. and Ma, J. and Zhang, M. and Li, C.}, title = {{Prevalence of mild cognitive impairment in community-dwelling Chinese populations aged over 55 years: a meta-analysis and systematic review}}, journal = {BMC geriatrics}, year = {2021}, doi = {10.1186/s12877-020-01948-3}, pmid = {33407219}, url = {https://doi.org/10.1186/s12877-020-01948-3} } @article{cheng2012-22372522, author = {Cheng, G. and Huang, C. and Deng, H. and Wang, H.}, title = {{Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies}}, journal = {Internal medicine journal}, year = {2012}, doi = {10.1111/j.1445-5994.2012.02758.x}, pmid = {22372522}, url = {https://doi.org/10.1111/j.1445-5994.2012.02758.x} } @article{jack2009-19339253, author = {Jack, C. R. and Lowe, V. J. and Weigand, S. D. and Wiste, H. J. and Senjem, M. L. and Knopman, D. S. and Shiung, M. M. and Gunter, J. L. and others}, title = {{Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2009}, doi = {10.1093/brain/awp062}, pmid = {19339253}, url = {https://doi.org/10.1093/brain/awp062} } @article{mattssoncarlgren2020-33068398, author = {Mattsson-Carlgren, N. and Janelidze, S. and Palmqvist, S. and Cullen, N. and Svenningsson, A. L. and Strandberg, O. and Mengel, D. and Walsh, D. M. and others}, title = {{Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2020}, doi = {10.1093/brain/awaa286}, pmid = {33068398}, url = {https://doi.org/10.1093/brain/awaa286} } @article{li2016-26001840, author = {Li, J. Q. and Tan, L. and Wang, H. F. and Tan, M. S. and Xu, W. and Zhao, Q. F. and Wang, J. and others}, title = {{Risk factors for predicting progression from mild cognitive impairment to Alzheimer's disease: a systematic review and meta-analysis of cohort studies}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2016}, doi = {10.1136/jnnp-2014-310095}, pmid = {26001840}, url = {https://doi.org/10.1136/jnnp-2014-310095} } @article{monteroodasso2018-29661156, author = {Montero-Odasso, M. and Almeida, Q. J. and Burhan, A. M. and Camicioli, R. and Doyon, J. and Fraser, S. and Li, K. and Liu-Ambrose, T. and others}, title = {{SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment}}, journal = {BMC geriatrics}, year = {2018}, doi = {10.1186/s12877-018-0782-7}, pmid = {29661156}, url = {https://doi.org/10.1186/s12877-018-0782-7} } @article{forlenza2019-30947755, author = {Forlenza, Orestes V and Radanovic, Márcia and Talib, Leda L and Gattaz, Wagner F}, title = {{Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial}}, journal = {The British journal of psychiatry : the journal of mental science}, year = {2019}, doi = {10.1192/bjp.2019.76}, pmid = {30947755}, url = {https://doi.org/10.1192/bjp.2019.76} } @article{jones2023-37156876, author = {Jones, Kevin T and Ostrand, Avery E and Gazzaley, Adam and Zanto, Theodore P}, title = {{Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial}}, journal = {Scientific reports}, year = {2023}, doi = {10.1038/s41598-023-34582-1}, pmid = {37156876}, url = {https://doi.org/10.1038/s41598-023-34582-1} } @article{wilkins2022-36190710, author = {Wilkins, C. H. and Windon, C. C. and Dilworth-Anderson, P. and Romanoff, J. and Gatsonis, C. and Hanna, L. and Apgar, C. and Gareen, I. F. and others}, title = {{Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia: A Secondary Analysis of the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Cohort Study}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.3157}, pmid = {36190710}, url = {https://doi.org/10.1001/jamaneurol.2022.3157} } @article{craft2012-21911655, author = {Craft, S. and Baker, L. D. and Montine, T. J. and Minoshima, S. and Watson, G. S. and Claxton, A. and Arbuckle, M. and Callaghan, M. and others}, title = {{Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial}}, journal = {Archives of neurology}, year = {2012}, doi = {10.1001/archneurol.2011.233}, pmid = {21911655}, url = {https://doi.org/10.1001/archneurol.2011.233} } @article{salloway2004-15326237, author = {Salloway, S. and Ferris, S. and Kluger, A. and Goldman, R. and Griesing, T. and Kumar, D. and Richardson, S. and {Donepezil 401 Study Group}}, title = {{Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000134664.80320.92}, pmid = {15326237}, url = {https://doi.org/10.1212/01.wnl.0000134664.80320.92} } @article{coric2015-26414022, author = {Coric, V. and Salloway, S. and van Dyck, C. H. and Dubois, B. and Andreasen, N. and Brody, M. and Curtis, C. and Soininen, H. and others}, title = {{Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2015.0607}, pmid = {26414022}, url = {https://doi.org/10.1001/jamaneurol.2015.0607} } @article{petersen2018-29282327, author = {Petersen, R. C. and Lopez, O. and Armstrong, M. J. and Getchius, T. S. D. and Ganguli, M. and Gloss, D. and Gronseth, G. S. and Marson, D. and others}, title = {{Practice guideline update summary: Mild cognitive impairment [RETIRED]: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000004826}, pmid = {29282327}, url = {https://doi.org/10.1212/wnl.0000000000004826} } @article{demurtas2020-32981668, author = {Demurtas, J. and Schoene, D. and Torbahn, G. and Marengoni, A. and Grande, G. and Zou, L. and Petrovic, M. and Maggi, S. and others}, title = {{Physical Activity and Exercise in Mild Cognitive Impairment and Dementia: An Umbrella Review of Intervention and Observational Studies}}, journal = {Journal of the American Medical Directors Association}, year = {2020}, doi = {10.1016/j.jamda.2020.08.031}, pmid = {32981668}, url = {https://doi.org/10.1016/j.jamda.2020.08.031} } @article{douaud2013-23690582, author = {Douaud, G. and Refsum, H. and de Jager, C. A. and Jacoby, R. and Nichols, T. E. and Smith, S. M. and Smith, A. D.}, title = {{Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2013}, doi = {10.1073/pnas.1301816110}, pmid = {23690582}, url = {https://doi.org/10.1073/pnas.1301816110} } @article{ornish2024-38849944, author = {Ornish, D. and Madison, C. and Kivipelto, M. and Kemp, C. and McCulloch, C. E. and Galasko, D. and Artz, J. and Rentz, D. and others}, title = {{Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial}}, journal = {Alzheimer's research \& therapy}, year = {2024}, doi = {10.1186/s13195-024-01482-z}, pmid = {38849944}, url = {https://doi.org/10.1186/s13195-024-01482-z} } @article{martin2019-31424410, author = {Martin, D. M. and Mohan, A. and Alonzo, A. and Gates, N. and Gbadeyan, O. and Meinzer, M. and Sachdev, P. and Brodaty, H. and others}, title = {{A Pilot Double-Blind Randomized Controlled Trial of Cognitive Training Combined with Transcranial Direct Current Stimulation for Amnestic Mild Cognitive Impairment}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2019}, doi = {10.3233/jad-190306}, pmid = {31424410}, url = {https://doi.org/10.3233/jad-190306} } @article{xu2020-33194354, author = {Xu, Z. and Zhang, D. and Lee, A. T. C. and Sit, R. W. S. and Wong, C. and Lee, E. K. P. and Yip, B. H. K. and Tiu, J. Y. S. and others}, title = {{A pilot feasibility randomized controlled trial on combining mind-body physical exercise, cognitive training, and nurse-led risk factor modification to reduce cognitive decline among older adults with mild cognitive impairment in primary care}}, journal = {PeerJ}, year = {2020}, doi = {10.7717/peerj.9845}, pmid = {33194354}, url = {https://doi.org/10.7717/peerj.9845} } @article{olazaran2004-15623698, author = {Olazarán, J. and Muñiz, R. and Reisberg, B. and Peña-Casanova, J. and del Ser, T. and Cruz-Jentoft, A. J. and Serrano, P. and Navarro, E. and others}, title = {{Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000147478.03911.28}, pmid = {15623698}, url = {https://doi.org/10.1212/01.wnl.0000147478.03911.28} } @article{luchsinger2016-26890736, author = {Luchsinger, J. A. and Perez, T. and Chang, H. and Mehta, P. and Steffener, J. and Pradabhan, G. and Ichise, M. and Manly, J. and others}, title = {{Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2016}, doi = {10.3233/jad-150493}, pmid = {26890736}, url = {https://doi.org/10.3233/jad-150493} } @article{gates2013-23831175, author = {Gates, N. and Fiatarone Singh, M. A. and Sachdev, P. S. and Valenzuela, M.}, title = {{The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2013}, doi = {10.1016/j.jagp.2013.02.018}, pmid = {23831175}, url = {https://doi.org/10.1016/j.jagp.2013.02.018} } @article{schrag2023-36342675, author = {Schrag, A. and Bohlken, J. and Dammertz, L. and Teipel, S. and Hermann, W. and Akmatov, M. K. and Bätzing, J. and Holstiege, J.}, title = {{Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2022.3902}, pmid = {36342675}, url = {https://doi.org/10.1001/jamaneurol.2022.3902} } @article{altomare2023-37155177, author = {Altomare, D. and Barkhof, F. and Caprioglio, C. and Collij, L. E. and Scheltens, P. and Lopes Alves, I. and Bouwman, F. and Berkhof, J. and others}, title = {{Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The AMYPAD-DPMS Randomized Clinical Trial}}, journal = {JAMA neurology}, year = {2023}, doi = {10.1001/jamaneurol.2023.0997}, pmid = {37155177}, url = {https://doi.org/10.1001/jamaneurol.2023.0997} } @article{fleisher2008-18195264, author = {Fleisher, A. S. and Sun, S. and Taylor, C. and Ward, C. P. and Gamst, A. C. and Petersen, R. C. and Jack, C. R. and Aisen, P. S. and others}, title = {{Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment}}, journal = {Neurology}, year = {2008}, doi = {10.1212/01.wnl.0000287091.57376.65}, pmid = {18195264}, url = {https://doi.org/10.1212/01.wnl.0000287091.57376.65} } @article{ismail2017-27893026, author = {Ismail, Z. and Elbayoumi, H. and Fischer, C. E. and Hogan, D. B. and Millikin, C. P. and Schweizer, T. and Mortby, M. E. and Smith, E. E. and others}, title = {{Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis}}, journal = {JAMA psychiatry}, year = {2017}, doi = {10.1001/jamapsychiatry.2016.3162}, pmid = {27893026}, url = {https://doi.org/10.1001/jamapsychiatry.2016.3162} } @article{varma2018-29370177, author = {Varma, V. R. and Oommen, A. M. and Varma, S. and Casanova, R. and An, Y. and Andrews, R. M. and O'Brien, R. and Pletnikova, O. and others}, title = {{Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study}}, journal = {PLoS medicine}, year = {2018}, doi = {10.1371/journal.pmed.1002482}, pmid = {29370177}, url = {https://doi.org/10.1371/journal.pmed.1002482} } @article{donohue2017-28609533, author = {Donohue, M. C. and Sperling, R. A. and Petersen, R. and Sun, C. K. and Weiner, M. W. and Aisen, P. S. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons}}, journal = {JAMA}, year = {2017}, doi = {10.1001/jama.2017.6669}, pmid = {28609533}, url = {https://doi.org/10.1001/jama.2017.6669} } @article{feldman2007-17509485, author = {Feldman, H. H. and Ferris, S. and Winblad, B. and Sfikas, N. and Mancione, L. and He, Y. and Tekin, S. and Burns, A. and others}, title = {{Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study}}, journal = {The Lancet. Neurology}, year = {2007}, doi = {10.1016/s1474-4422(07)70109-6}, pmid = {17509485}, url = {https://doi.org/10.1016/s1474-4422(07)70109-6} } @article{mccleery2018-30383288, author = {McCleery, J. and Abraham, R. P. and Denton, D. A. and Rutjes, A. W. and Chong, L. Y. and Al-Assaf, A. S. and Griffith, D. J. and Rafeeq, S. and others}, title = {{Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment}}, journal = {The Cochrane database of systematic reviews}, year = {2018}, doi = {10.1002/14651858.cd011905.pub2}, pmid = {30383288}, url = {https://doi.org/10.1002/14651858.cd011905.pub2} } @article{masuoka2019-31319510, author = {Masuoka, Nobutaka and Yoshimine, Chitose and Hori, Marie and Tanaka, Mieko and Asada, Takashi and Abe, Keiichi and Hisatsune, Tatsuhiro}, title = {{Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4}}, journal = {Nutrients}, year = {2019}, doi = {10.3390/nu11071626}, pmid = {31319510}, url = {https://doi.org/10.3390/nu11071626} } @article{liu2026-42869847, author = {Liu, Xulin and de Boer, Sterre C M and Tartaglia, Maria Carmela and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Sex-specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71913}, pmid = {42869847}, url = {https://doi.org/10.1002/alz.71913} } @article{jia2021-32967819, author = {Jia, Feifei and Li, Yanyan and Li, Min and Cao, Fenglin}, title = {{Subjective Cognitive Decline, Cognitive Reserve Indicators, and the Incidence of Dementia}}, journal = {Journal of the American Medical Directors Association}, year = {2021}, doi = {10.1016/j.jamda.2020.08.005}, pmid = {32967819}, url = {https://doi.org/10.1016/j.jamda.2020.08.005} } @article{baker2025-40271888, author = {Baker, L. D. and Pa, J. A. and Katula, J. A. and Aslanyan, V. and Salmon, D. P. and Jacobs, D. M. and Chmelo, E. A. and Hodge, H. and Morrison, R. and Matthews, G. and others}, title = {{Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.14586}, pmid = {40271888}, url = {https://doi.org/10.1002/alz.14586} } @article{mattssoncarlgren2026-41864233, author = {Mattsson-Carlgren, Niklas and Palmqvist, Sebastian and Horie, Kanta and Barthélemy, Nicolas and Salvadó, Gemma and Binette, Alexa Pichet and Tideman, Pontus and Morris, John C and others}, title = {{Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study}}, journal = {The Lancet. Neurology}, year = {2026}, doi = {10.1016/S1474-4422(26)00029-3}, pmid = {41864233}, url = {https://doi.org/10.1016/S1474-4422(26)00029-3} } @article{salvado2025-40952756, author = {Salvadó, G. and Janelidze, S. and Bali, D. and Dolado, A. O. and Therriault, J. and Brum, W. S. and Pichet Binette, A. and Stomrud, E. and Mattsson-Carlgren, N. and Palmqvist, S. and Coomans, E. M. and Teunissen, C. E. and others}, title = {{Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease}}, journal = {JAMA Neurology}, year = {2025}, doi = {10.1001/jamaneurol.2025.3217}, pmid = {40952756}, url = {https://doi.org/10.1001/jamaneurol.2025.3217} } @article{palmqvist2015-26354982, author = {Palmqvist, S. and Zetterberg, H. and Mattsson, N. and Johansson, P. and {Alzheimer's Disease Neuroimaging Initiative} and Minthon, L. and Blennow, K. and Olsson, M. and others}, title = {{Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001991}, pmid = {26354982}, url = {https://doi.org/10.1212/wnl.0000000000001991} } @article{holper2024-38986050, author = {Holper, S. and Loveland, P. and Churilov, L. and Italiano, D. and Watson, R. and Yassi, N.}, title = {{Blood Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-Analysis}}, journal = {Neurology}, year = {2024}, doi = {10.1212/wnl.0000000000209537}, pmid = {38986050}, url = {https://doi.org/10.1212/wnl.0000000000209537} } @article{landau2010-20592257, author = {Landau, S. M. and Harvey, D. and Madison, C. M. and Reiman, E. M. and Foster, N. L. and Aisen, P. S. and Petersen, R. C. and Shaw, L. M. and others}, title = {{Comparing predictors of conversion and decline in mild cognitive impairment}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181e8e8b8}, pmid = {20592257}, url = {https://doi.org/10.1212/wnl.0b013e3181e8e8b8} } @article{shumaker2003-12771112, author = {Shumaker, S. A. and Legault, C. and Rapp, SR. and Thal, L. and Wallace, R. B. and Ockene, J. K. and Hendrix, S. L. and Jones, B. N. and others}, title = {{Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial}}, journal = {JAMA}, year = {2003}, doi = {10.1001/jama.289.20.2651}, pmid = {12771112}, url = {https://doi.org/10.1001/jama.289.20.2651} } @article{arevalorodriguez2015-25740785, author = {Arevalo-Rodriguez, I. and Smailagic, N. and Roqué I Figuls, M. and Ciapponi, A. and Sanchez-Perez, E. and Giannakou, A. and Pedraza, O. L. and Bonfill Cosp, X. and others}, title = {{Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)}}, journal = {The Cochrane database of systematic reviews}, year = {2015}, doi = {10.1002/14651858.cd010783.pub2}, pmid = {25740785}, url = {https://doi.org/10.1002/14651858.cd010783.pub2} } @article{baker2011-20837822, author = {Baker, L. D. and Cross, D. J. and Minoshima, S. and Belongia, D. and Watson, G. S. and Craft, S.}, title = {{Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2010.225}, pmid = {20837822}, url = {https://doi.org/10.1001/archneurol.2010.225} } @article{janelidze2023-36087307, author = {Janelidze, S. and Bali, D. and Ashton, N. J. and Barthélemy, N. R. and Vanbrabant, J. and Stoops, E. and Vanmechelen, E. and others}, title = {{Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2023}, doi = {10.1093/brain/awac333}, pmid = {36087307}, url = {https://doi.org/10.1093/brain/awac333} } @article{thal2005-15742005, author = {Thal, L. J. and Ferris, S. H. and Kirby, L. and Block, G. A. and Lines, C. R. and Yuen, E. and Assaid, C. and Nessly, M. L. and others}, title = {{A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment}}, journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology}, year = {2005}, doi = {10.1038/sj.npp.1300690}, pmid = {15742005}, url = {https://doi.org/10.1038/sj.npp.1300690} } @article{baiano2020-31743500, author = {Baiano, C. and Barone, P. and Trojano, L. and Santangelo, G.}, title = {{Prevalence and clinical aspects of mild cognitive impairment in Parkinson's disease: A meta-analysis}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2020}, doi = {10.1002/mds.27902}, pmid = {31743500}, url = {https://doi.org/10.1002/mds.27902} } @article{russ2012-22972133, author = {Russ, T. C. and Morling, JR.}, title = {{Cholinesterase inhibitors for mild cognitive impairment}}, journal = {The Cochrane database of systematic reviews}, year = {2012}, doi = {10.1002/14651858.cd009132.pub2}, pmid = {22972133}, url = {https://doi.org/10.1002/14651858.cd009132.pub2} } @article{fiataronesingh2014-25444575, author = {Fiatarone Singh, M. A. and Gates, N. and Saigal, N. and Wilson, G. C. and Meiklejohn, J. and Brodaty, H. and Wen, W. and Singh, N. and others}, title = {{The Study of Mental and Resistance Training (SMART) study—resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial}}, journal = {Journal of the American Medical Directors Association}, year = {2014}, doi = {10.1016/j.jamda.2014.09.010}, pmid = {25444575}, url = {https://doi.org/10.1016/j.jamda.2014.09.010} } @article{loy2006-16437436, author = {Loy, C. and Schneider, L.}, title = {{Galantamine for Alzheimer's disease and mild cognitive impairment}}, journal = {The Cochrane database of systematic reviews}, year = {2006}, doi = {10.1002/14651858.cd001747.pub3}, pmid = {16437436}, url = {https://doi.org/10.1002/14651858.cd001747.pub3} } @article{jones2025-39889875, author = {Jones, Aaron and Ali, Muhammad Usman and Mayhew, Alexandra and Aryal, Komal and Correia, Rebecca H. and Dash, Darly and Manis, Derek R. and Rehman, Atiya and others}, title = {{Environmental risk factors for all-cause dementia, Alzheimer's disease dementia, vascular dementia, and mild cognitive impairment: An umbrella review and meta-analysis}}, journal = {Environmental Research}, year = {2025}, doi = {10.1016/j.envres.2025.121007}, pmid = {39889875}, url = {https://doi.org/10.1016/j.envres.2025.121007} } @article{heneka2025-40050444, author = {Heneka, M. T. and Gauthier, S. and Chandekar, S. A. and Hviid Hahn-Pedersen, J. and Bentsen, M. A. and Zetterberg, H.}, title = {{Neuroinflammatory fluid biomarkers in patients with Alzheimer's disease: a systematic literature review}}, journal = {Molecular psychiatry}, year = {2025}, doi = {10.1038/s41380-025-02939-9}, pmid = {40050444}, url = {https://doi.org/10.1038/s41380-025-02939-9} } @article{karikari2020-01fa071e, author = {Karikari, T. K. and Benedet, A. L. and Ashton, N. J. and Rodriguez, J. L. and Snellman, A. and Suárez-Calvet, M. and Chaudhuri, P. S. and Lussier, F. and others}, title = {{Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative}}, journal = {Molecular psychiatry}, year = {2020}, doi = {10.1101/2020.07.15.20154237}, url = {https://doi.org/10.1101/2020.07.15.20154237} } @article{sherman2017-29282641, author = {Sherman, D. S. and Mauser, J. and Nuno, M. and Sherzai, D.}, title = {{The Efficacy of Cognitive Intervention in Mild Cognitive Impairment (MCI): a Meta-Analysis of Outcomes on Neuropsychological Measures}}, journal = {Neuropsychology review}, year = {2017}, doi = {10.1007/s11065-017-9363-3}, pmid = {29282641}, url = {https://doi.org/10.1007/s11065-017-9363-3} } @article{jean2010-20220584, author = {Jean, L. and Bergeron, M. E. and Thivierge, S. and Simard, M.}, title = {{Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2010}, doi = {10.1097/jgp.0b013e3181c37ce9}, pmid = {20220584}, url = {https://doi.org/10.1097/jgp.0b013e3181c37ce9} } @article{han2017-27802233, author = {Han, J. W. and Lee, H. and Hong, J. W. and Kim, K. and Kim, T. and Byun, H. J. and Ko, J. W. and Youn, J. C. and others}, title = {{Multimodal Cognitive Enhancement Therapy for Patients with Mild Cognitive Impairment and Mild Dementia: A Multi- Center, Randomized, Controlled, Double-Blind, Crossover Trial}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2017}, doi = {10.3233/jad-160619}, pmid = {27802233}, url = {https://doi.org/10.3233/jad-160619} } @article{perna2023-37951931, author = {Perna, L. and Stocker, H. and Burow, L. and Beyer, L. and Trares, K. and Kurz, C. and Gürsel, S. and Holleczek, B. and others}, title = {{Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study}}, journal = {Alzheimer's research \& therapy}, year = {2023}, doi = {10.1186/s13195-023-01341-3}, pmid = {37951931}, url = {https://doi.org/10.1186/s13195-023-01341-3} } @article{huang2024-38501315, author = {Huang, S. Y. and Zhang, Y. R. and Guo, Y. and Du, J. and Ren, P. and Wu, B. S. and Feng, J. F. and {Alzheimer's Disease Neuroimaging Initiative} and Cheng, W. and Yu, J. T.}, title = {{Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease}}, journal = {Alzheimer's \& Dementia}, year = {2024}, doi = {10.1002/alz.13789}, pmid = {38501315}, url = {https://doi.org/10.1002/alz.13789} } @article{kern2018-29653987, author = {Kern, S. and Zetterberg, H. and Kern, J. and Zettergren, A. and Waern, M. and Höglund, K. and Andreasson, U. and Wetterberg, H. and others}, title = {{Prevalence of preclinical Alzheimer disease: Comparison of current classification systems}}, journal = {Neurology}, year = {2018}, doi = {10.1212/wnl.0000000000005476}, pmid = {29653987}, url = {https://doi.org/10.1212/wnl.0000000000005476} } @article{manly2022-36279130, author = {Manly, J. J. and Jones, R. N. and Langa, K. M. and Ryan, L. H. and Levine, D. A. and McCammon, R. and Heeringa, S. G. and Weir, D.}, title = {{Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.3543}, pmid = {36279130}, url = {https://doi.org/10.1001/jamaneurol.2022.3543} } @article{vandenberghe2010-20687209, author = {Vandenberghe, R. and Van Laere, K. and Ivanoiu, A. and Salmon, E. and Bastin, C. and Triau, E. and Hasselbalch, S. and Law, I. and others}, title = {{18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial}}, journal = {Annals of neurology}, year = {2010}, doi = {10.1002/ana.22068}, pmid = {20687209}, url = {https://doi.org/10.1002/ana.22068} } @article{orgeta2020-32101639, author = {Orgeta, V. and McDonald, K. R. and Poliakoff, E. and Hindle, J. V. and Clare, L. and Leroi, I.}, title = {{Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease}}, journal = {The Cochrane database of systematic reviews}, year = {2020}, doi = {10.1002/14651858.cd011961.pub2}, pmid = {32101639}, url = {https://doi.org/10.1002/14651858.cd011961.pub2} } @article{mitchell2009-19236314, author = {Mitchell, A. J. and Shiri-Feshki, M.}, title = {{Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies}}, journal = {Acta psychiatrica Scandinavica}, year = {2009}, doi = {10.1111/j.1600-0447.2008.01326.x}, pmid = {19236314}, url = {https://doi.org/10.1111/j.1600-0447.2008.01326.x} } @article{yaffe2011-21828324, author = {Yaffe, K. and Laffan, A. M. and Harrison, S. L. and Redline, S. and Spira, A. P. and Ensrud, K. E. and Ancoli-Israel, S. and Stone, K. L.}, title = {{Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women}}, journal = {JAMA}, year = {2011}, doi = {10.1001/jama.2011.1115}, pmid = {21828324}, url = {https://doi.org/10.1001/jama.2011.1115} } @article{palmqvist2021-34031605, author = {Palmqvist, S. and Tideman, P. and Cullen, N. and Zetterberg, H. and Blennow, K. and {Alzheimer’s Disease Neuroimaging Initiative} and Dage, J. L. and Stomrud, E. and others}, title = {{Prediction of future Alzheimer's disease dementia using plasma phospho-tau combined with other accessible measures}}, journal = {Nature medicine}, year = {2021}, doi = {10.1038/s41591-021-01348-z}, pmid = {34031605}, url = {https://doi.org/10.1038/s41591-021-01348-z} } @article{schroeter2009-19463961, author = {Schroeter, M. L. and Stein, T. and Maslowski, N. and Neumann, J.}, title = {{Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients}}, journal = {NeuroImage}, year = {2009}, doi = {10.1016/j.neuroimage.2009.05.037}, pmid = {19463961}, url = {https://doi.org/10.1016/j.neuroimage.2009.05.037} } @article{lombardi2020-32119112, author = {Lombardi, G. and Crescioli, G. and Cavedo, E. and Lucenteforte, E. and Casazza, G. and Bellatorre, A. G. and Lista, C. and Costantino, G. and others}, title = {{Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment}}, journal = {The Cochrane database of systematic reviews}, year = {2020}, doi = {10.1002/14651858.cd009628.pub2}, pmid = {32119112}, url = {https://doi.org/10.1002/14651858.cd009628.pub2} } @article{vanloenhoud2019-31266904, author = {van Loenhoud, A. C. and van der Flier, W. M. and Wink, A. M. and Dicks, E. and Groot, C. and Twisk, J. and Barkhof, F. and Scheltens, P. and others}, title = {{Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship}}, journal = {Neurology}, year = {2019}, doi = {10.1212/wnl.0000000000007821}, pmid = {31266904}, url = {https://doi.org/10.1212/wnl.0000000000007821} } @article{smith2020-33439987, author = {Smith, R. and Strandberg, O. and Mattsson-Carlgren, N. and Leuzy, A. and Palmqvist, S. and Pontecorvo, M. J. and Devous, M. D. and Ossenkoppele, R. and others}, title = {{The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects}}, journal = {Brain : a journal of neurology}, year = {2020}, doi = {10.1093/brain/awaa327}, pmid = {33439987}, url = {https://doi.org/10.1093/brain/awaa327} } @article{gates2019-30864747, author = {Gates, N. J. and Vernooij, R. W. and Di Nisio, M. and Karim, S. and March, E. and Martínez, G. and Rutjes, A. W.}, title = {{Computerised cognitive training for preventing dementia in people with mild cognitive impairment}}, journal = {The Cochrane database of systematic reviews}, year = {2019}, doi = {10.1002/14651858.cd012279.pub2}, pmid = {30864747}, url = {https://doi.org/10.1002/14651858.cd012279.pub2} } @article{blackman2021-33289311, author = {Blackman, J. and Swirski, M. and Clynes, J. and Harding, S. and Leng, Y. and Coulthard, E.}, title = {{Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review}}, journal = {Journal of sleep research}, year = {2021}, doi = {10.1111/jsr.13229}, pmid = {33289311}, url = {https://doi.org/10.1111/jsr.13229} } @article{blennow2019-31836810, author = {Blennow, K. and Shaw, L. M. and Stomrud, E. and Mattsson, N. and Toledo, J. B. and Buck, K. and Wahl, S. and Eichenlaub, U. and others}, title = {{Predicting clinical decline and conversion to Alzheimer's disease or dementia using novel Elecsys Aβ(1-42), pTau and tTau CSF immunoassays}}, journal = {Scientific reports}, year = {2019}, doi = {10.1038/s41598-019-54204-z}, pmid = {31836810}, url = {https://doi.org/10.1038/s41598-019-54204-z} } @article{morato2023-37012306, author = {Morató, X. and Marquié, M. and Tartari, J. P. and Lafuente, A. and Abdelnour, C. and Alegret, M. and Jofresa, S. and Buendía, M. and others}, title = {{A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress}}, journal = {Scientific reports}, year = {2023}, doi = {10.1038/s41598-023-32515-6}, pmid = {37012306}, url = {https://doi.org/10.1038/s41598-023-32515-6} } @article{rojas2013-23414646, author = {Rojas, G. J. and Villar, V. and Iturry, M. and Harris, P. and Serrano, C. M. and Herrera, J. A. and Allegri, R. F.}, title = {{Efficacy of a cognitive intervention program in patients with mild cognitive impairment}}, journal = {International psychogeriatrics}, year = {2013}, doi = {10.1017/s1041610213000045}, pmid = {23414646}, url = {https://doi.org/10.1017/s1041610213000045} } @article{contrerassomoza2021-33967901, author = {Contreras-Somoza, L. M. and Irazoki, E. and Toribio-Guzmán, J. M. and de la Torre-Díez, I. and Diaz-Baquero, A. A. and Parra-Vidales, E. and Perea-Bartolomé, M. V. and MÁ, Franco-Martín}, title = {{Usability and User Experience of Cognitive Intervention Technologies for Elderly People With MCI or Dementia: A Systematic Review}}, journal = {Frontiers in psychology}, year = {2021}, doi = {10.3389/fpsyg.2021.636116}, pmid = {33967901}, url = {https://doi.org/10.3389/fpsyg.2021.636116} } @article{hassandra2021-33759797, author = {Hassandra, M. and Galanis, E. and Hatzigeorgiadis, A. and Goudas, M. and Mouzakidis, C. and Karathanasi, E. M. and Petridou, N. and Tsolaki, M. and others}, title = {{Α Virtual Reality App for Physical and Cognitive Training of Older People With Mild Cognitive Impairment: Mixed Methods Feasibility Study}}, journal = {JMIR serious games}, year = {2021}, doi = {10.2196/24170}, pmid = {33759797}, url = {https://doi.org/10.2196/24170} } @article{bernini2019-31256092, author = {Bernini, S. and Alloni, A. and Panzarasa, S. and Picascia, M. and Quaglini, S. and Tassorelli, C. and Sinforiani, E.}, title = {{A computer-based cognitive training in Mild Cognitive Impairment in Parkinson's Disease}}, journal = {NeuroRehabilitation}, year = {2019}, doi = {10.3233/nre-192714}, pmid = {31256092}, url = {https://doi.org/10.3233/nre-192714} } @article{chae2023-36468299, author = {Chae, H. J. and Lee, S. H.}, title = {{Effectiveness of online-based cognitive intervention in community-dwelling older adults with cognitive dysfunction: A systematic review and meta-analysis}}, journal = {International journal of geriatric psychiatry}, year = {2023}, doi = {10.1002/gps.5853}, pmid = {36468299}, url = {https://doi.org/10.1002/gps.5853} } @article{wells2013-24120430, author = {Wells, R. E. and Yeh, G. Y. and Kerr, C. E. and Wolkin, J. and Davis, R. B. and Tan, Y. and Spaeth, R. and Wall, R. B. and others}, title = {{Meditation's impact on default mode network and hippocampus in mild cognitive impairment: a pilot study}}, journal = {Neuroscience letters}, year = {2013}, doi = {10.1016/j.neulet.2013.10.001}, pmid = {24120430}, url = {https://doi.org/10.1016/j.neulet.2013.10.001} } @article{jonaitis2023-37013174, author = {Jonaitis, E. M. and Janelidze, S. and Cody, K. A. and Langhough, R. and Du, L. and Chin, N. A. and Mattsson-Carlgren, N. and Hogan, K. J. and others}, title = {{Plasma phosphorylated tau 217 in preclinical Alzheimer's disease}}, journal = {Brain communications}, year = {2023}, doi = {10.1093/braincomms/fcad057}, pmid = {37013174}, url = {https://doi.org/10.1093/braincomms/fcad057} } @article{kim2023-37174709, author = {Kim, K. Y. and Shin, K. Y. and Chang, K. A.}, title = {{GFAP as a Potential Biomarker for Alzheimer's Disease: A Systematic Review and Meta-Analysis}}, journal = {Cells}, year = {2023}, doi = {10.3390/cells12091309}, pmid = {37174709}, url = {https://doi.org/10.3390/cells12091309} } @article{liu2022-35535875, author = {Liu, W. L. and Lin, H. W. and Lin, M. R. and Yu, Y. and Liu, H. H. and Dai, Y. L. and Chen, L. W. and Jia, W. W. and others}, title = {{Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer's disease: a meta-analysis and systematic review}}, journal = {Neural regeneration research}, year = {2022}, doi = {10.4103/1673-5374.335832}, pmid = {35535875}, url = {https://doi.org/10.4103/1673-5374.335832} } @article{chan2018-29921507, author = {Chan, J. Y. C. and Kwong, J. S. W. and Wong, A. and Kwok, T. C. Y. and Tsoi, K. K. F.}, title = {{Comparison of Computerized and Paper-and-Pencil Memory Tests in Detection of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies}}, journal = {Journal of the American Medical Directors Association}, year = {2018}, doi = {10.1016/j.jamda.2018.05.010}, pmid = {29921507}, url = {https://doi.org/10.1016/j.jamda.2018.05.010} } @article{cavallo2019-29295652, author = {Cavallo, M. and Angilletta, C.}, title = {{Long-Lasting Neuropsychological Effects of a Computerized Cognitive Training in Patients Affected by Early Stage Alzheimer's Disease: Are They Stable Over Time?}}, journal = {Journal of applied gerontology : the official journal of the Southern Gerontological Society}, year = {2019}, doi = {10.1177/0733464817750276}, pmid = {29295652}, url = {https://doi.org/10.1177/0733464817750276} } @article{papp2017-29264389, author = {Papp, K. V. and Rentz, D. M. and Orlovsky, I. and Sperling, R. A. and Mormino, E. C.}, title = {{Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2017}, doi = {10.1016/j.trci.2017.10.004}, pmid = {29264389}, url = {https://doi.org/10.1016/j.trci.2017.10.004} } @article{ibrahim2021-33942449, author = {Ibrahim, B. and Suppiah, S. and Ibrahim, N. and Mohamad, M. and Hassan, H. A. and Nasser, N. S. and Saripan, M. I.}, title = {{Diagnostic power of resting-state fMRI for detection of network connectivity in Alzheimer's disease and mild cognitive impairment: A systematic review}}, journal = {Human brain mapping}, year = {2021}, doi = {10.1002/hbm.25369}, pmid = {33942449}, url = {https://doi.org/10.1002/hbm.25369} } @article{green2019-30652263, author = {Green, A. R. and Reifler, L. M. and Bayliss, E. A. and Weffald, L. A. and Boyd, C. M.}, title = {{Drugs Contributing to Anticholinergic Burden and Risk of Fall or Fall-Related Injury among Older Adults with Mild Cognitive Impairment, Dementia and Multiple Chronic Conditions: A Retrospective Cohort Study}}, journal = {Drugs \& aging}, year = {2019}, doi = {10.1007/s40266-018-00630-z}, pmid = {30652263}, url = {https://doi.org/10.1007/s40266-018-00630-z} } @article{study2026-42163294, title = {{Plasma p-tau217, p-tau181, and Aβ42 predict amyloid PET positivity in cognitively unimpaired adults}}, journal = {Alzheimer's research \& therapy}, year = {2026}, doi = {10.1186/s13195-026-02080-x}, pmid = {42163294}, url = {https://doi.org/10.1186/s13195-026-02080-x} } @article{cui2023-37357299, author = {Cui, L and Huang, L and Pan, F-F and Wang, Y and Huang, Q and Guan, Y-H and Lo, C-Y Z and Guo, Y-H and others}, title = {{Chinese Preclinical Alzheimer's Disease Study (C-PAS): Design and Challenge from PET Acceptance}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2023}, doi = {10.14283/jpad.2023.49}, pmid = {37357299}, url = {https://doi.org/10.14283/jpad.2023.49} } @article{dodel2025-40790925, author = {Dodel, Richard and Frölich, Lutz}, title = {{Donanemab for Alzheimer's disease: from preclinical research to the clinical application}}, journal = {Expert review of neurotherapeutics}, year = {2025}, doi = {10.1080/14737175.2025.2546868}, pmid = {40790925}, url = {https://doi.org/10.1080/14737175.2025.2546868} } @article{gardener2021-34719491, author = {Gardener, Hannah and Levin, Bonnie and DeRosa, Janet and Rundek, Tatjana and Wright, Clinton B and Elkind, Mitchell S V and Sacco, Ralph L}, title = {{Social Connectivity is Related to Mild Cognitive Impairment and Dementia}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2021}, doi = {10.3233/jad-210519}, pmid = {34719491}, url = {https://doi.org/10.3233/jad-210519} } @article{zabalafindlay2023-37190093, author = {Zabala-Findlay, A. and Penny, L. K. and Lofthouse, R. A. and Porter, A. J. and Palliyil, S. and Harrington, C. R. and Wischik, C. M. and Arastoo, M.}, title = {{Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis}}, journal = {Cells}, year = {2023}, doi = {10.3390/cells12081184}, pmid = {37190093}, url = {https://doi.org/10.3390/cells12081184} } @article{thomas2021-34692978, author = {Thomas, K. R. and Bangen, K. J. and Edmonds, E. C. and Weigand, A. J. and Walker, K. S. and Bondi, M. W. and Galasko, D. R. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease-related declines}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2021}, doi = {10.1002/dad2.12238}, pmid = {34692978}, url = {https://doi.org/10.1002/dad2.12238} } @article{sewell2024-38488949, author = {Sewell, K. R. and Rainey-Smith, SR. and Pedrini, S. and Peiffer, J. J. and Sohrabi, H. R. and Taddei, K. and Markovic, S. J. and Martins, R. N. and others}, title = {{The impact of exercise on blood-based biomarkers of Alzheimer's disease in cognitively unimpaired older adults}}, journal = {GeroScience}, year = {2024}, doi = {10.1007/s11357-024-01130-2}, pmid = {38488949}, url = {https://doi.org/10.1007/s11357-024-01130-2} } @article{yakoub2025-40008832, author = {Yakoub, Y. and Gonzalez-Ortiz, F. and Ashton, N. J. and Déry, C. and Strikwerda-Brown, C. and St-Onge, F. and Ourry, V. and Schöll, M. and Geddes, M. R. and Ducharme, S. and Montembeault, M. and Rosa-Neto, P. and others}, title = {{Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.14537}, pmid = {40008832}, url = {https://doi.org/10.1002/alz.14537} } @article{planche2023-36261295, author = {Planche, V. and Bouteloup, V. and Pellegrin, I. and Mangin, J. F. and Dubois, B. and Ousset, P. J. and Pasquier, F. and Blanc, F. and others}, title = {{Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000201479}, pmid = {36261295}, url = {https://doi.org/10.1212/wnl.0000000000201479} } @article{gonzalezortiz2025-40373247, author = {Gonzalez-Ortiz, F. and Kirsebom, B. E. and Yakoub, Y. and Gundersen, J. K. and Pålhaugen, L. and Waterloo, K. and Selnes, P. and Jarholm, J. A. and others}, title = {{Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213676}, pmid = {40373247}, url = {https://doi.org/10.1212/wnl.0000000000213676} } @article{singh2014-24164735, author = {Singh, B. and Parsaik, A. K. and Mielke, M. M. and Erwin, P. J. and Knopman, D. S. and Petersen, R. C. and Roberts, R. O.}, title = {{Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2014}, doi = {10.3233/jad-130830}, pmid = {24164735}, url = {https://doi.org/10.3233/jad-130830} } @article{sperling2011-21514248, author = {Sperling, R. A. and Aisen, P. S. and Beckett, L. A. and Bennett, D. A. and Craft, S. and Fagan, A. M. and Iwatsubo, T. and Jack, C. R. and others}, title = {{Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2011}, doi = {10.1016/j.jalz.2011.03.003}, pmid = {21514248}, url = {https://doi.org/10.1016/j.jalz.2011.03.003} } @article{ancelin2006-16452102, author = {Ancelin, M. L. and Artero, S. and Portet, F. and Dupuy, A. M. and Touchon, J. and Ritchie, K.}, title = {{Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study}}, journal = {BMJ (Clinical research ed.)}, year = {2006}, doi = {10.1136/bmj.38740.439664.de}, pmid = {16452102}, url = {https://doi.org/10.1136/bmj.38740.439664.de} } @article{groot2024-38857029, author = {Groot, C. and Smith, R. and Collij, L. E. and Mastenbroek, S. E. and Stomrud, E. and Binette, A. P. and Leuzy, A. and Palmqvist, S. and others}, title = {{Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment}}, journal = {JAMA neurology}, year = {2024}, doi = {10.1001/jamaneurol.2024.1612}, pmid = {38857029}, url = {https://doi.org/10.1001/jamaneurol.2024.1612} } @article{petersen1999-10190820, author = {Petersen, R. C. and Smith, G. E. and Waring, S. C. and Ivnik, R. J. and Tangalos, E. G. and Kokmen, E.}, title = {{Mild cognitive impairment: clinical characterization and outcome}}, journal = {Archives of neurology}, year = {1999}, doi = {10.1001/archneur.56.3.303}, pmid = {10190820}, url = {https://doi.org/10.1001/archneur.56.3.303} } @article{solfrizzi2004-15557506, author = {Solfrizzi, V. and Panza, F. and Colacicco, A. M. and D'Introno, A. and Capurso, C. and Torres, F. and Grigoletto, F. and Maggi, S. and others}, title = {{Vascular risk factors, incidence of MCI, and rates of progression to dementia}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000144281.38555.e3}, pmid = {15557506}, url = {https://doi.org/10.1212/01.wnl.0000144281.38555.e3} } @article{ansart2021-33091740, author = {Ansart, M. and Epelbaum, S. and Bassignana, G. and Bône, A. and Bottani, S. and Cattai, T. and Couronné, R. and Faouzi, J. and others}, title = {{Predicting the progression of mild cognitive impairment using machine learning: A systematic, quantitative and critical review}}, journal = {Medical image analysis}, year = {2021}, doi = {10.1016/j.media.2020.101848}, pmid = {33091740}, url = {https://doi.org/10.1016/j.media.2020.101848} } @article{dotson2010-20603482, author = {Dotson, V. M. and Beydoun, M. A. and Zonderman, A. B.}, title = {{Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181e62124}, pmid = {20603482}, url = {https://doi.org/10.1212/wnl.0b013e3181e62124} } @article{driscoll2009-19487648, author = {Driscoll, I. and Davatzikos, C. and An, Y. and Wu, X. and Shen, D. and Kraut, M. and Resnick, S. M.}, title = {{Longitudinal pattern of regional brain volume change differentiates normal aging from MCI}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181a82634}, pmid = {19487648}, url = {https://doi.org/10.1212/wnl.0b013e3181a82634} } @article{richard2013-23599941, author = {Richard, E. and Reitz, C. and Honig, L. H. and Schupf, N. and Tang, M. X. and Manly, J. J. and Mayeux, R. and Devanand, D. and others}, title = {{Late-life depression, mild cognitive impairment, and dementia}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.603}, pmid = {23599941}, url = {https://doi.org/10.1001/jamaneurol.2013.603} } @article{reynolds2011-21199965, author = {Reynolds, C. F. and Butters, M. A. and Lopez, O. and Pollock, B. G. and Dew, M. A. and Mulsant, B. H. and Lenze, E. J. and Holm, M. and others}, title = {{Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy}}, journal = {Archives of general psychiatry}, year = {2011}, doi = {10.1001/archgenpsychiatry.2010.184}, pmid = {21199965}, url = {https://doi.org/10.1001/archgenpsychiatry.2010.184} } @article{frolich2017-29017593, author = {Frölich, L. and Peters, O. and Lewczuk, P. and Gruber, O. and Teipel, S. J. and Gertz, H. J. and Jahn, H. and Jessen, F. and others}, title = {{Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia}}, journal = {Alzheimer's research \& therapy}, year = {2017}, doi = {10.1186/s13195-017-0301-7}, pmid = {29017593}, url = {https://doi.org/10.1186/s13195-017-0301-7} } @article{ebenau2022-35110378, author = {Ebenau, Jarith L and Pelkmans, Wiesje and Verberk, Inge M W and Verfaillie, Sander C J and van den Bosch, Karlijn A and van Leeuwenstijn, Mardou and Collij, Lyduine E and Scheltens, Philip and others}, title = {{Association of CSF, Plasma, and Imaging Markers of Neurodegeneration With Clinical Progression in People With Subjective Cognitive Decline}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200035}, pmid = {35110378}, url = {https://doi.org/10.1212/wnl.0000000000200035} } @article{polk2026-42270927, author = {Polk, Sarah E and Clark, Lindsay R and Basche, Kristin and Kleineidam, Luca and Glanz, Wenzel and Butryn, Michaela and Perneczky, Robert and Buerger, Katharina and others}, title = {{Smartphone-based detection of subtle memory decline in prodromal Alzheimer's disease}}, journal = {NPJ digital medicine}, year = {2026}, doi = {10.1038/s41746-026-02731-1}, pmid = {42270927}, url = {https://doi.org/10.1038/s41746-026-02731-1} } @article{fei2023-36990042, author = {Fei, Yuzhe and Wang, Ruiru and Lu, Jiachun and Peng, Songhao and Yang, Song and Wang, Yiting and Zheng, Kaixuan and Li, Ran and others}, title = {{Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment}}, journal = {Geriatric nursing (New York, N.Y.)}, year = {2023}, doi = {10.1016/j.gerinurse.2023.03.006}, pmid = {36990042}, url = {https://doi.org/10.1016/j.gerinurse.2023.03.006} } @article{shadyab2026-41805953, author = {Shadyab, A. H. and Zhang, B. and LaCroix, A. Z. and Mielke, M. M. and Resnick, S. M. and Nguyen, S. and Ferrucci, L. and Libermann, T. A. and Ngo, L. and Casanova, R. and others}, title = {{Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women}}, journal = {JAMA Network Open}, year = {2026}, doi = {10.1001/jamanetworkopen.2026.1295}, pmid = {41805953}, url = {https://doi.org/10.1001/jamanetworkopen.2026.1295} } @article{luchsinger2007-17420320, author = {Luchsinger, J. A. and Reitz, C. and Patel, B. and Tang, M. X. and Manly, J. J. and Mayeux, R.}, title = {{Relation of diabetes to mild cognitive impairment}}, journal = {Archives of neurology}, year = {2007}, doi = {10.1001/archneur.64.4.570}, pmid = {17420320}, url = {https://doi.org/10.1001/archneur.64.4.570} } @article{roberts2016-26569387, author = {Roberts, R. O. and Christianson, T. J. and Kremers, W. K. and Mielke, M. M. and Machulda, M. M. and Vassilaki, M. and Alhurani, R. E. and Geda, Y. E. and others}, title = {{Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2015.2952}, pmid = {26569387}, url = {https://doi.org/10.1001/jamaneurol.2015.2952} } @article{fleisher2007-17287448, author = {Fleisher, A. S. and Sowell, B. B. and Taylor, C. and Gamst, A. C. and Petersen, R. C. and Thal, L. J. and {Alzheimer's Disease Cooperative Study}}, title = {{Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000258542.58725.4c}, pmid = {17287448}, url = {https://doi.org/10.1212/01.wnl.0000258542.58725.4c} } @article{baker2012-22869065, author = {Baker, L. D. and Barsness, S. M. and Borson, S. and Merriam, G. R. and Friedman, S. D. and Craft, S. and Vitiello, M. V.}, title = {{Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial}}, journal = {Archives of neurology}, year = {2012}, doi = {10.1001/archneurol.2012.1970}, pmid = {22869065}, url = {https://doi.org/10.1001/archneurol.2012.1970} } @article{schneider2019-31492718, author = {Schneider, L. S. and Geffen, Y. and Rabinowitz, J. and Thomas, R. G. and Schmidt, R. and Ropele, S. and Weinstock, M. and {Ladostigil Study Group}}, title = {{Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial}}, journal = {Neurology}, year = {2019}, doi = {10.1212/wnl.0000000000008239}, pmid = {31492718}, url = {https://doi.org/10.1212/wnl.0000000000008239} } @article{andre2023-37258299, author = {André, C. and Kuhn, E. and Rehel, S. and Ourry, V. and Demeilliez-Servouin, S. and Palix, C. and Felisatti, F. and Champetier, P. and others}, title = {{Association of Sleep-Disordered Breathing and Medial Temporal Lobe Atrophy in Cognitively Unimpaired Amyloid-Positive Older Adults}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207421}, pmid = {37258299}, url = {https://doi.org/10.1212/wnl.0000000000207421} } @article{rabin2018-29799986, author = {Rabin, J. S. and Schultz, A. P. and Hedden, T. and Viswanathan, A. and Marshall, G. A. and Kilpatrick, E. and Klein, H. and Buckley, R. F. and others}, title = {{Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2018.1123}, pmid = {29799986}, url = {https://doi.org/10.1001/jamaneurol.2018.1123} } @article{busse2006-17190940, author = {Busse, A. and Hensel, A. and Gühne, U. and Angermeyer, M. C. and Riedel-Heller, S. G.}, title = {{Mild cognitive impairment: long-term course of four clinical subtypes}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000249117.23318.e1}, pmid = {17190940}, url = {https://doi.org/10.1212/01.wnl.0000249117.23318.e1} } @article{barnes2006-16520432, author = {Barnes, D. E. and Alexopoulos, G. S. and Lopez, O. L. and Williamson, J. D. and Yaffe, K.}, title = {{Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study}}, journal = {Archives of general psychiatry}, year = {2006}, doi = {10.1001/archpsyc.63.3.273}, pmid = {16520432}, url = {https://doi.org/10.1001/archpsyc.63.3.273} } @article{gonzalez2019-31753701, author = {González, H. M. and Tarraf, W. and Schneiderman, N. and Fornage, M. and Vásquez, P. M. and Zeng, D. and Youngblood, M. and Gallo, L. C. and others}, title = {{Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.08.202}, pmid = {31753701}, url = {https://doi.org/10.1016/j.jalz.2019.08.202} } @article{dejager2012-21780182, author = {de Jager, C. A. and Oulhaj, A. and Jacoby, R. and Refsum, H. and Smith, A. D.}, title = {{Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial}}, journal = {International journal of geriatric psychiatry}, year = {2012}, doi = {10.1002/gps.2758}, pmid = {21780182}, url = {https://doi.org/10.1002/gps.2758} } @article{petersen2005-15829527, author = {Petersen, R. C. and Thomas, R. G. and Grundman, M. and Bennett, D. and Doody, R. and Ferris, S. and Galasko, D. and Jin, S. and others}, title = {{Vitamin E and donepezil for the treatment of mild cognitive impairment}}, journal = {The New England journal of medicine}, year = {2005}, doi = {10.1056/nejmoa050151}, pmid = {15829527}, url = {https://doi.org/10.1056/nejmoa050151} } @article{coppola2015-26252902, author = {Coppola, G. and Di Renzo, A. and Ziccardi, L. and Martelli, F. and Fadda, A. and Manni, G. and Barboni, P. and Pierelli, F. and others}, title = {{Optical Coherence Tomography in Alzheimer's Disease: A Meta-Analysis}}, journal = {PloS one}, year = {2015}, doi = {10.1371/journal.pone.0134750}, pmid = {26252902}, url = {https://doi.org/10.1371/journal.pone.0134750} } @article{bucci2021-34593971, author = {Bucci, M. and Chiotis, K. and Nordberg, A. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline}}, journal = {Molecular psychiatry}, year = {2021}, doi = {10.1038/s41380-021-01263-2}, pmid = {34593971}, url = {https://doi.org/10.1038/s41380-021-01263-2} } @article{stephan2012-22143004, author = {Stephan, B. C. and Hunter, S. and Harris, D. and Llewellyn, D. J. and Siervo, M. and Matthews, F. E. and Brayne, C.}, title = {{The neuropathological profile of mild cognitive impairment (MCI): a systematic review}}, journal = {Molecular psychiatry}, year = {2012}, doi = {10.1038/mp.2011.147}, pmid = {22143004}, url = {https://doi.org/10.1038/mp.2011.147} } @article{eikelboom2021-34413181, author = {Eikelboom, W. S. and van den Berg, E. and Singleton, E. H. and Baart, S. J. and Coesmans, M. and Leeuwis, A. E. and Teunissen, C. E. and van Berckel, B. N. M. and others}, title = {{Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum: Cross-sectional and Longitudinal Associations}}, journal = {Neurology}, year = {2021}, doi = {10.1212/wnl.0000000000012598}, pmid = {34413181}, url = {https://doi.org/10.1212/wnl.0000000000012598} } @article{weiner2015-26073027, author = {Weiner, M. W. and Veitch, D. P. and Aisen, P. S. and Beckett, L. A. and Cairns, N. J. and Cedarbaum, J. and Green, R. C. and Harvey, D. and others}, title = {{2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2014.11.001}, pmid = {26073027}, url = {https://doi.org/10.1016/j.jalz.2014.11.001} } @article{smailagic2015-25629415, author = {Smailagic, N. and Vacante, M. and Hyde, C. and Martin, S. and Ukoumunne, O. and Sachpekidis, C.}, title = {{¹⁸F-FDG PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)}}, journal = {The Cochrane database of systematic reviews}, year = {2015}, doi = {10.1002/14651858.cd010632.pub2}, pmid = {25629415}, url = {https://doi.org/10.1002/14651858.cd010632.pub2} } @article{ge2018-30219036, author = {Ge, S. and Zhu, Z. and Wu, B. and McConnell, E. S.}, title = {{Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: a systematic review}}, journal = {BMC geriatrics}, year = {2018}, doi = {10.1186/s12877-018-0893-1}, pmid = {30219036}, url = {https://doi.org/10.1186/s12877-018-0893-1} } @article{bhome2018-30030318, author = {Bhome, R. and Berry, A. J. and Huntley, J. D. and Howard, R. J.}, title = {{Interventions for subjective cognitive decline: systematic review and meta-analysis}}, journal = {BMJ open}, year = {2018}, doi = {10.1136/bmjopen-2018-021610}, pmid = {30030318}, url = {https://doi.org/10.1136/bmjopen-2018-021610} } @article{clay2020-32280091, author = {Clay, F. and Howett, D. and FitzGerald, J. and Fletcher, P. and Chan, D. and Price, A.}, title = {{Use of Immersive Virtual Reality in the Assessment and Treatment of Alzheimer's Disease: A Systematic Review}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2020}, doi = {10.3233/jad-191218}, pmid = {32280091}, url = {https://doi.org/10.3233/jad-191218} } @article{li2019-30708349, author = {Li, B. Y. and He, N. Y. and Qiao, Y. and Xu, H. M. and Lu, Y. Z. and Cui, P. J. and Ling, H. W. and Yan, F. H. and others}, title = {{Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study}}, journal = {NeuroImage. Clinical}, year = {2019}, doi = {10.1016/j.nicl.2019.101691}, pmid = {30708349}, url = {https://doi.org/10.1016/j.nicl.2019.101691} } @article{zhao2018-30087557, author = {Zhao, J. and Li, H. and Lin, R. and Wei, Y. and Yang, A.}, title = {{Effects of creative expression therapy for older adults with mild cognitive impairment at risk of Alzheimer's disease: a randomized controlled clinical trial}}, journal = {Clinical interventions in aging}, year = {2018}, doi = {10.2147/cia.s161861}, pmid = {30087557}, url = {https://doi.org/10.2147/cia.s161861} } @article{peng2019-31886216, author = {Peng, Z. and Jiang, H. and Wang, X. and Huang, K. and Zuo, Y. and Wu, X. and Abdullah, A. S. and Yang, L.}, title = {{The Efficacy of Cognitive Training for Elderly Chinese Individuals with Mild Cognitive Impairment}}, journal = {BioMed research international}, year = {2019}, doi = {10.1155/2019/4347281}, pmid = {31886216}, url = {https://doi.org/10.1155/2019/4347281} } @article{marciniak2020-32848377, author = {Marciniak, R. and Šumec, R. and Vyhnálek, M. and Bendíčková, K. and Lázničková, P. and Forte, G. and Jeleník, A. and Římalová, V. and others}, title = {{The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study}}, journal = {Clinical interventions in aging}, year = {2020}, doi = {10.2147/cia.s249196}, pmid = {32848377}, url = {https://doi.org/10.2147/cia.s249196} } @article{desousa2020-32280093, author = {de Sousa, A. V. C. and Grittner, U. and Rujescu, D. and Külzow, N. and Flöel, A.}, title = {{Impact of 3-Day Combined Anodal Transcranial Direct Current Stimulation-Visuospatial Training on Object-Location Memory in Healthy Older Adults and Patients with Mild Cognitive Impairment}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2020}, doi = {10.3233/jad-191234}, pmid = {32280093}, url = {https://doi.org/10.3233/jad-191234} } @article{mcmaster2018-30538436, author = {McMaster, M. and Kim, S. and Clare, L. and Torres, S. J. and D'Este, C. and Anstey, K. J.}, title = {{Body, Brain, Life for Cognitive Decline (BBL-CD): protocol for a multidomain dementia risk reduction randomized controlled trial for subjective cognitive decline and mild cognitive impairment}}, journal = {Clinical interventions in aging}, year = {2018}, doi = {10.2147/cia.s182046}, pmid = {30538436}, url = {https://doi.org/10.2147/cia.s182046} } @article{sayma2020-31600389, author = {Sayma, M. and Tuijt, R. and Cooper, C. and Walters, K.}, title = {{Are We There Yet? Immersive Virtual Reality to Improve Cognitive Function in Dementia and Mild Cognitive Impairment}}, journal = {The Gerontologist}, year = {2020}, doi = {10.1093/geront/gnz132}, pmid = {31600389}, url = {https://doi.org/10.1093/geront/gnz132} } @article{saloner2024-37639492, author = {Saloner, R. and VandeVrede, L. and Asken, B. M. and Paolillo, E. W. and Gontrum, E. Q. and Wolf, A. and Lario-Lago, A. and Milà-Alomà, M. and others}, title = {{Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13454}, pmid = {37639492}, url = {https://doi.org/10.1002/alz.13454} } @article{hackett2022-32684106, author = {Hackett, K. and Lehman, S. and Divers, R. and Ambrogi, M. and Gomes, L. and Tan, C. C. and Giovannetti, T.}, title = {{Remind Me To Remember: A pilot study of a novel smartphone reminder application for older adults with dementia and mild cognitive impairment}}, journal = {Neuropsychological rehabilitation}, year = {2022}, doi = {10.1080/09602011.2020.1794909}, pmid = {32684106}, url = {https://doi.org/10.1080/09602011.2020.1794909} } @article{koscik2020-32211502, author = {Koscik, R. L. and Betthauser, T. J. and Jonaitis, E. M. and Allison, S. L. and Clark, L. R. and Hermann, B. P. and Cody, K. A. and Engle, J. W. and others}, title = {{Amyloid duration is associated with preclinical cognitive decline and tau PET}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2020}, doi = {10.1002/dad2.12007}, pmid = {32211502}, url = {https://doi.org/10.1002/dad2.12007} } @article{vergallo2019-31113759, author = {Vergallo, A. and Mégret, L. and Lista, S. and Cavedo, E. and Zetterberg, H. and Blennow, K. and Vanmechelen, E. and De Vos, A. and others}, title = {{Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.03.009}, pmid = {31113759}, url = {https://doi.org/10.1016/j.jalz.2019.03.009} } @article{hwang2025-41388319, author = {Hwang, Jiyun and Moon, So Young and Lee, Harim and Lee, Jaejin and Park, Yoo Kyoung and Jeong, Jee Hyang and Hong, Chang Hyung and Jung, Jiwoo and others}, title = {{Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment}}, journal = {Alzheimer's research \& therapy}, year = {2025}, doi = {10.1186/s13195-025-01907-3}, pmid = {41388319}, url = {https://doi.org/10.1186/s13195-025-01907-3} } @article{sperling2020-32250387, author = {Sperling, R. A. and Donohue, M. C. and Raman, R. and Sun, C. K. and Yaari, R. and Holdridge, K. and Siemers, E. and Johnson, K. A. and others}, title = {{Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals}}, journal = {JAMA neurology}, year = {2020}, doi = {10.1001/jamaneurol.2020.0387}, pmid = {32250387}, url = {https://doi.org/10.1001/jamaneurol.2020.0387} } @article{cicognola2021-33773595, author = {Cicognola, C. and Janelidze, S. and Hertze, J. and Zetterberg, H. and Blennow, K. and Mattsson-Carlgren, N. and Hansson, O.}, title = {{Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00804-9}, pmid = {33773595}, url = {https://doi.org/10.1186/s13195-021-00804-9} } @article{yang2024-38315899, author = {Yang, H. S. and Yau, W. W. and Carlyle, B. C. and Trombetta, B. A. and Zhang, C. and Shirzadi, Z. and Schultz, A. P. and Pruzin, J. J. and others}, title = {{Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2024}, doi = {10.1093/brain/awae034}, pmid = {38315899}, url = {https://doi.org/10.1093/brain/awae034} } @article{doody2009-19176895, author = {Doody, R. S. and Ferris, S. H. and Salloway, S. and Sun, Y. and Goldman, R. and Watkins, W. E. and Xu, Y. and Murthy, A. K.}, title = {{Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial}}, journal = {Neurology}, year = {2009}, doi = {10.1212/01.wnl.0000344650.95823.03}, pmid = {19176895}, url = {https://doi.org/10.1212/01.wnl.0000344650.95823.03} } @article{bayercarter2011-21670398, author = {Bayer-Carter, J. L. and Green, P. S. and Montine, T. J. and VanFossen, B. and Baker, L. D. and Watson, G. S. and Bonner, L. M. and Callaghan, M. and others}, title = {{Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2011.125}, pmid = {21670398}, url = {https://doi.org/10.1001/archneurol.2011.125} } @article{pal2018-30182156, author = {Pal, K. and Mukadam, N. and Petersen, I. and Cooper, C.}, title = {{Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis}}, journal = {Social psychiatry and psychiatric epidemiology}, year = {2018}, doi = {10.1007/s00127-018-1581-3}, pmid = {30182156}, url = {https://doi.org/10.1007/s00127-018-1581-3} } @article{sarica2017-29056906, author = {Sarica, A. and Cerasa, A. and Quattrone, A.}, title = {{Random Forest Algorithm for the Classification of Neuroimaging Data in Alzheimer's Disease: A Systematic Review}}, journal = {Frontiers in aging neuroscience}, year = {2017}, doi = {10.3389/fnagi.2017.00329}, pmid = {29056906}, url = {https://doi.org/10.3389/fnagi.2017.00329} } @article{wu2019-31074810, author = {Wu, A. and Sharrett, A. R. and Gottesman, R. F. and Power, M. C. and Mosley, T. H. and Jack, C. R. and Knopman, D. S. and Windham, B. G. and others}, title = {{Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.3359}, pmid = {31074810}, url = {https://doi.org/10.1001/jamanetworkopen.2019.3359} } @article{deng2021-33756479, author = {Deng, Y. and Zhao, S. and Cheng, G. and Yang, J. and Li, B. and Xu, K. and Xiao, P. and Li, W. and others}, title = {{The Prevalence of Mild Cognitive Impairment among Chinese People: A Meta-Analysis}}, journal = {Neuroepidemiology}, year = {2021}, doi = {10.1159/000512597}, pmid = {33756479}, url = {https://doi.org/10.1159/000512597} } @article{postuma2012-22561644, author = {Postuma, R. B. and Lang, A. E. and Gagnon, J. F. and Pelletier, A. and Montplaisir, J. Y.}, title = {{How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder}}, journal = {Brain : a journal of neurology}, year = {2012}, doi = {10.1093/brain/aws093}, pmid = {22561644}, url = {https://doi.org/10.1093/brain/aws093} } @article{petersen2010-20042704, author = {Petersen, R. C. and Aisen, P. S. and Beckett, L. A. and Donohue, M. C. and Gamst, A. C. and Harvey, D. J. and Jack, C. R. and Jagust, W. J. and others}, title = {{Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181cb3e25}, pmid = {20042704}, url = {https://doi.org/10.1212/wnl.0b013e3181cb3e25} } @article{monteroodasso2017-28505243, author = {Montero-Odasso, M. M. and Sarquis-Adamson, Y. and Speechley, M. and Borrie, M. J. and Hachinski, V. C. and Wells, J. and Riccio, P. M. and Schapira, M. and others}, title = {{Association of Dual-Task Gait With Incident Dementia in Mild Cognitive Impairment: Results From the Gait and Brain Study}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.0643}, pmid = {28505243}, url = {https://doi.org/10.1001/jamaneurol.2017.0643} } @article{ayton2015-25988319, author = {Ayton, S. and Faux, N. G. and Bush, A. I. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE}}, journal = {Nature communications}, year = {2015}, doi = {10.1038/ncomms7760}, pmid = {25988319}, url = {https://doi.org/10.1038/ncomms7760} } @article{rosenberg2013-23567400, author = {Rosenberg, P. B. and Mielke, M. M. and Appleby, B. S. and Oh, E. S. and Geda, Y. E. and Lyketsos, C. G.}, title = {{The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2013}, doi = {10.1016/j.jagp.2013.01.006}, pmid = {23567400}, url = {https://doi.org/10.1016/j.jagp.2013.01.006} } @article{belleville2017-29019061, author = {Belleville, S. and Fouquet, C. and Hudon, C. and Zomahoun, H. T. V. and Croteau, J. and {Consortium for the Early Identification of Alzheimer’s disease-Quebec}}, title = {{Neuropsychological Measures that Predict Progression from Mild Cognitive Impairment to Alzheimer's type dementia in Older Adults: a Systematic Review and Meta-Analysis}}, journal = {Neuropsychology review}, year = {2017}, doi = {10.1007/s11065-017-9361-5}, pmid = {29019061}, url = {https://doi.org/10.1007/s11065-017-9361-5} } @article{mak2015-26173861, author = {Mak, E. and Su, L. and Williams, G. B. and Firbank, M. J. and Lawson, R. A. and Yarnall, A. J. and Duncan, G. W. and Owen, A. M. and others}, title = {{Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study}}, journal = {Brain : a journal of neurology}, year = {2015}, doi = {10.1093/brain/awv211}, pmid = {26173861}, url = {https://doi.org/10.1093/brain/awv211} } @article{pigott2015-26362285, author = {Pigott, K. and Rick, J. and Xie, S. X. and Hurtig, H. and Chen-Plotkin, A. and Duda, J. E. and Morley, J. F. and Chahine, L. M. and others}, title = {{Longitudinal study of normal cognition in Parkinson disease}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000002001}, pmid = {26362285}, url = {https://doi.org/10.1212/wnl.0000000000002001} } @article{atti2019-30917904, author = {Atti, A. R. and Valente, S. and Iodice, A. and Caramella, I. and Ferrari, B. and Albert, U. and Mandelli, L. and De Ronchi, D.}, title = {{Metabolic Syndrome, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Longitudinal Studies}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2019}, doi = {10.1016/j.jagp.2019.01.214}, pmid = {30917904}, url = {https://doi.org/10.1016/j.jagp.2019.01.214} } @article{asaoka2022-35570493, author = {Asaoka, D. and Xiao, J. and Takeda, T. and Yanagisawa, N. and Yamazaki, T. and Matsubara, Y. and Sugiyama, H. and Endo, N. and others}, title = {{Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2022}, doi = {10.3233/jad-220148}, pmid = {35570493}, url = {https://doi.org/10.3233/jad-220148} } @article{tifratene2015-26136516, author = {Tifratene, K. and Robert, P. and Metelkina, A. and Pradier, C. and Dartigues, J. F.}, title = {{Progression of mild cognitive impairment to dementia due to AD in clinical settings}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001788}, pmid = {26136516}, url = {https://doi.org/10.1212/wnl.0000000000001788} } @article{rostamzadeh2022-36028322, author = {Rostamzadeh, A. and Bohr, L. and Wagner, M. and Baethge, C. and Jessen, F.}, title = {{Progression of Subjective Cognitive Decline to MCI or Dementia in Relation to Biomarkers for Alzheimer Disease: A Meta-analysis}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201072}, pmid = {36028322}, url = {https://doi.org/10.1212/wnl.0000000000201072} } @article{kang2024-38959008, author = {Kang, M. and Li, C. and Mahajan, A. and Spat-Lemus, J. and Durape, S. and Chen, J. and Gurnani, A. S. and Devine, S. and others}, title = {{Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment}}, journal = {JAMA psychiatry}, year = {2024}, doi = {10.1001/jamapsychiatry.2024.1678}, pmid = {38959008}, url = {https://doi.org/10.1001/jamapsychiatry.2024.1678} } @article{tsoy2020-32582835, author = {Tsoy, Elena and Erlhoff, Sabrina J and Goode, Collette A and Dorsman, Karen A and Kanjanapong, Suchanan and Lindbergh, Cutter A and La Joie, Renaud and Strom, Amelia and others}, title = {{BHA-CS: A novel cognitive composite for Alzheimer's disease and related disorders}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2020}, doi = {10.1002/dad2.12042}, pmid = {32582835}, url = {https://doi.org/10.1002/dad2.12042} } @article{choi2026-42937433, author = {Choi, Alex and Haystead, Alice and D'Cunha, Rachel and Hsu, John and Zhu, Michael and Johnson, Kim G and Whitson, Heather and Grewal, Dilraj S and others}, title = {{Longitudinal Multimodal Retinal Imaging in Cognitively Normal Apolipoprotein E4 Carriers and Noncarriers}}, journal = {Translational vision science \& technology}, year = {2026}, doi = {10.1167/tvst.15.10.45}, pmid = {42937433}, url = {https://doi.org/10.1167/tvst.15.10.45} } @article{demnitzking2025-41130254, author = {Demnitz-King, H. and Adeleke, M. and Barber, J. A. and Poppe, M. and Budgett, J. and Alberts, S. and Duffy, L. and Minihane, A. M. and Gillings, R. and Chapman, H. and others}, title = {{Remote, lower-intensity, multidomain lifestyle intervention for subjective cognitive decline or mild cognitive impairment (APPLE-Tree): a multicentre, single-masked, randomised controlled trial}}, journal = {The Lancet Healthy Longevity}, year = {2025}, doi = {10.1016/j.lanhl.2025.100777}, pmid = {41130254}, url = {https://doi.org/10.1016/j.lanhl.2025.100777} } @article{fernandezgamez2026-41562376, author = {Fernandez-Gamez, B. and Solis-Urra, P. and Coca-Pulido, A. and Molina-Hidalgo, C. and Olvera-Rojas, M. and Bakker, E. A. and others}, title = {{Effect of a 24-week resistance exercise intervention on cognitive function in cognitively normal older adults: The AGUEDA randomized controlled trial}}, journal = {Alzheimer's \& Dementia}, year = {2026}, doi = {10.1002/alz.71019}, pmid = {41562376}, url = {https://doi.org/10.1002/alz.71019} } @article{zetterberg2016-26524180, author = {Zetterberg, H. and Skillbäck, T. and Mattsson, N. and Trojanowski, J. Q. and Portelius, E. and Shaw, L. M. and Weiner, M. W. and Blennow, K. and others}, title = {{Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2015.3037}, pmid = {26524180}, url = {https://doi.org/10.1001/jamaneurol.2015.3037} } @article{mattssoncarlgren2020-32398359, author = {Mattsson-Carlgren, N. and Leuzy, A. and Janelidze, S. and Palmqvist, S. and Stomrud, E. and Strandberg, O. and Smith, R. and Hansson, O.}, title = {{The implications of different approaches to define AT(N) in Alzheimer disease}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009485}, pmid = {32398359}, url = {https://doi.org/10.1212/wnl.0000000000009485} } @article{gertje2023-36882326, author = {Gertje, E. C. and Janelidze, S. and van Westen, D. and Cullen, N. and Stomrud, E. and Palmqvist, S. and Hansson, O. and Mattsson-Carlgren, N.}, title = {{Associations Between CSF Markers of Inflammation, White Matter Lesions, and Cognitive Decline in Individuals Without Dementia}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207113}, pmid = {36882326}, url = {https://doi.org/10.1212/wnl.0000000000207113} } @article{vanrossum2012-23019259, author = {van Rossum, I. A. and Vos, S. J. and Burns, L. and Knol, D. L. and Scheltens, P. and Soininen, H. and Wahlund, L. O. and Hampel, H. and others}, title = {{Injury markers predict time to dementia in subjects with MCI and amyloid pathology}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182704056}, pmid = {23019259}, url = {https://doi.org/10.1212/wnl.0b013e3182704056} } @article{rajji2025-39476073, author = {Rajji, T. K. and Bowie, C. R. and Herrmann, N. and Pollock, B. G. and Lanctôt, K. L. and Kumar, S. and Flint, A. J. and Mah, L. and others}, title = {{Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial}}, journal = {JAMA psychiatry}, year = {2025}, doi = {10.1001/jamapsychiatry.2024.3241}, pmid = {39476073}, url = {https://doi.org/10.1001/jamapsychiatry.2024.3241} } @article{hoops2009-19933974, author = {Hoops, S. and Nazem, S. and Siderowf, A. D. and Duda, J. E. and Xie, S. X. and Stern, M. B. and Weintraub, D.}, title = {{Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181c34b47}, pmid = {19933974}, url = {https://doi.org/10.1212/wnl.0b013e3181c34b47} } @article{kapogiannis2015-25342129, author = {Kapogiannis, D. and Boxer, A. and Schwartz, J. B. and Abner, E. L. and Biragyn, A. and Masharani, U. and Frassetto, L. and Petersen, R. C. and others}, title = {{Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease}}, journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year = {2015}, doi = {10.1096/fj.14-262048}, pmid = {25342129}, url = {https://doi.org/10.1096/fj.14-262048} } @article{fagan2007-17210801, author = {Fagan, A. M. and Roe, C. M. and Xiong, C. and Mintun, M. A. and Morris, J. C. and Holtzman, D. M.}, title = {{Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults}}, journal = {Archives of neurology}, year = {2007}, doi = {10.1001/archneur.64.3.noc60123}, pmid = {17210801}, url = {https://doi.org/10.1001/archneur.64.3.noc60123} } @article{ossenkoppele2019-30626656, author = {Ossenkoppele, R. and Smith, R. and Ohlsson, T. and Strandberg, O. and Mattsson, N. and Insel, P. S. and Palmqvist, S. and Hansson, O.}, title = {{Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease}}, journal = {Neurology}, year = {2019}, doi = {10.1212/wnl.0000000000006875}, pmid = {30626656}, url = {https://doi.org/10.1212/wnl.0000000000006875} } @article{bakkour2009-19109536, author = {Bakkour, A. and Morris, J. C. and Dickerson, B. C.}, title = {{The cortical signature of prodromal AD: regional thinning predicts mild AD dementia}}, journal = {Neurology}, year = {2009}, doi = {10.1212/01.wnl.0000340981.97664.2f}, pmid = {19109536}, url = {https://doi.org/10.1212/01.wnl.0000340981.97664.2f} } @article{jessen2010-20368517, author = {Jessen, F. and Wiese, B. and Bachmann, C. and Eifflaender-Gorfer, S. and Haller, F. and Kölsch, H. and Luck, T. and Mösch, E. and others}, title = {{Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment}}, journal = {Archives of general psychiatry}, year = {2010}, doi = {10.1001/archgenpsychiatry.2010.30}, pmid = {20368517}, url = {https://doi.org/10.1001/archgenpsychiatry.2010.30} } @article{visser2009-19523877, author = {Visser, P. J. and Verhey, F. and Knol, D. L. and Scheltens, P. and Wahlund, L. O. and Freund-Levi, Y. and Tsolaki, M. and Minthon, L. and others}, title = {{Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study}}, journal = {The Lancet. Neurology}, year = {2009}, doi = {10.1016/s1474-4422(09)70139-5}, pmid = {19523877}, url = {https://doi.org/10.1016/s1474-4422(09)70139-5} } @article{geda2008-18838636, author = {Geda, Y. E. and Roberts, R. O. and Knopman, D. S. and Petersen, R. C. and Christianson, T. J. and Pankratz, V. S. and Smith, G. E. and Boeve, B. F. and others}, title = {{Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study}}, journal = {Archives of general psychiatry}, year = {2008}, doi = {10.1001/archpsyc.65.10.1193}, pmid = {18838636}, url = {https://doi.org/10.1001/archpsyc.65.10.1193} } @article{song2021-34751136, author = {Song, T. and Song, X. and Zhu, C. and Patrick, R. and Skurla, M. and Santangelo, I. and Green, M. and Harper, D. and others}, title = {{Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies}}, journal = {Ageing research reviews}, year = {2021}, doi = {10.1016/j.arr.2021.101503}, pmid = {34751136}, url = {https://doi.org/10.1016/j.arr.2021.101503} } @article{villain2012-22628162, author = {Villain, N. and Chételat, G. and Grassiot, B. and Bourgeat, P. and Jones, G. and Ellis, K. A. and Ames, D. and Martins, R. N. and others}, title = {{Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study}}, journal = {Brain : a journal of neurology}, year = {2012}, doi = {10.1093/brain/aws125}, pmid = {22628162}, url = {https://doi.org/10.1093/brain/aws125} } @article{gates2011-21942932, author = {Gates, N. J. and Sachdev, P. S. and Fiatarone Singh, M. A. and Valenzuela, M.}, title = {{Cognitive and memory training in adults at risk of dementia: a systematic review}}, journal = {BMC geriatrics}, year = {2011}, doi = {10.1186/1471-2318-11-55}, pmid = {21942932}, url = {https://doi.org/10.1186/1471-2318-11-55} } @article{petersen2016-26595683, author = {Petersen, R. C. and Wiste, H. J. and Weigand, S. D. and Rocca, W. A. and Roberts, R. O. and Mielke, M. M. and Lowe, V. J. and Knopman, D. S. and others}, title = {{Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2015.3098}, pmid = {26595683}, url = {https://doi.org/10.1001/jamaneurol.2015.3098} } @article{fortier2021-33103819, author = {Fortier, M. and Castellano, C. A. and St-Pierre, V. and É, Myette-Côté and Langlois, F. and Roy, M. and Morin, M. C. and Bocti, C. and others}, title = {{A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2021}, doi = {10.1002/alz.12206}, pmid = {33103819}, url = {https://doi.org/10.1002/alz.12206} } @article{cholerton2018-29478836, author = {Cholerton, B. and Johnson, C. O. and Fish, B. and Quinn, J. F. and Chung, K. A. and Peterson-Hiller, A. L. and Rosenthal, L. S. and Dawson, T. M. and others}, title = {{Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease}}, journal = {Parkinsonism \& related disorders}, year = {2018}, doi = {10.1016/j.parkreldis.2018.02.007}, pmid = {29478836}, url = {https://doi.org/10.1016/j.parkreldis.2018.02.007} } @article{slot2018-30081935, author = {Slot, R. E. R. and Verfaillie, S. C. J. and Overbeek, J. M. and Timmers, T. and Wesselman, L. M. P. and Teunissen, C. E. and Dols, A. and Bouwman, F. H. and others}, title = {{Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results}}, journal = {Alzheimer's research \& therapy}, year = {2018}, doi = {10.1186/s13195-018-0390-y}, pmid = {30081935}, url = {https://doi.org/10.1186/s13195-018-0390-y} } @article{eliassonnenschein2011-21493755, author = {Elias-Sonnenschein, L. S. and Viechtbauer, W. and Ramakers, I. H. and Verhey, F. R. and Visser, P. J.}, title = {{Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2011}, doi = {10.1136/jnnp.2010.231555}, pmid = {21493755}, url = {https://doi.org/10.1136/jnnp.2010.231555} } @article{lu2009-19528519, author = {Lu, P. H. and Edland, S. D. and Teng, E. and Tingus, K. and Petersen, R. C. and Cummings, J. L. and {Alzheimer's Disease Cooperative Study Group}}, title = {{Donepezil delays progression to AD in MCI subjects with depressive symptoms}}, journal = {Neurology}, year = {2009}, doi = {10.1212/wnl.0b013e3181aa52d3}, pmid = {19528519}, url = {https://doi.org/10.1212/wnl.0b013e3181aa52d3} } @article{singh2014-24637951, author = {Singh, B. and Mielke, M. M. and Parsaik, A. K. and Cha, R. H. and Roberts, R. O. and Scanlon, P. D. and Geda, Y. E. and Christianson, T. J. and others}, title = {{A prospective study of chronic obstructive pulmonary disease and the risk for mild cognitive impairment}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.94}, pmid = {24637951}, url = {https://doi.org/10.1001/jamaneurol.2014.94} } @article{kleineidam2020-32166339, author = {Kleineidam, L. and Chouraki, V. and Próchnicki, T. and van der Lee, S. J. and Madrid-Márquez, L. and Wagner-Thelen, H. and Karaca, I. and Weinhold, L. and others}, title = {{PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment}}, journal = {Acta neuropathologica}, year = {2020}, doi = {10.1007/s00401-020-02138-6}, pmid = {32166339}, url = {https://doi.org/10.1007/s00401-020-02138-6} } @article{stark2023-37821235, author = {Stark, M. and Wolfsgruber, S. and Kleineidam, L. and Frommann, I. and Altenstein, S. and Bartels, C. and Brosseron, F. and Buerger, K. and others}, title = {{Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000207844}, pmid = {37821235}, url = {https://doi.org/10.1212/wnl.0000000000207844} } @article{thapa2020-32365533, author = {Thapa, N. and Park, H. J. and Yang, J. G. and Son, H. and Jang, M. and Lee, J. and Kang, S. W. and Park, K. W. and others}, title = {{The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial}}, journal = {Journal of clinical medicine}, year = {2020}, doi = {10.3390/jcm9051283}, pmid = {32365533}, url = {https://doi.org/10.3390/jcm9051283} } @article{lam2015-25826620, author = {Lam, L. C. and Chan, W. C. and Leung, T. and Fung, A. W. and Leung, E. M.}, title = {{Would older adults with mild cognitive impairment adhere to and benefit from a structured lifestyle activity intervention to enhance cognition?: a cluster randomized controlled trial}}, journal = {PloS one}, year = {2015}, doi = {10.1371/journal.pone.0118173}, pmid = {25826620}, url = {https://doi.org/10.1371/journal.pone.0118173} } @article{cullen2021-37117993, author = {Cullen, N. C. and Leuzy, A. and Palmqvist, S. and Janelidze, S. and Stomrud, E. and Pesini, P. and Sarasa, L. and Allué, J. A. and others}, title = {{Individualized prognosis of cognitive decline and dementia in mild cognitive impairment based on plasma biomarker combinations}}, journal = {Nature aging}, year = {2021}, doi = {10.1038/s43587-020-00003-5}, pmid = {37117993}, url = {https://doi.org/10.1038/s43587-020-00003-5} } @article{ju2013-23479184, author = {Ju, Y. E. and McLeland, J. S. and Toedebusch, C. D. and Xiong, C. and Fagan, A. M. and Duntley, S. P. and Morris, J. C. and Holtzman, D. M.}, title = {{Sleep quality and preclinical Alzheimer disease}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.2334}, pmid = {23479184}, url = {https://doi.org/10.1001/jamaneurol.2013.2334} } @article{hu2021-31650255, author = {Hu, M. and Wu, X. and Shu, X. and Hu, H. and Chen, Q. and Peng, L. and Feng, H.}, title = {{Effects of computerised cognitive training on cognitive impairment: a meta-analysis}}, journal = {Journal of neurology}, year = {2021}, doi = {10.1007/s00415-019-09522-7}, pmid = {31650255}, url = {https://doi.org/10.1007/s00415-019-09522-7} } @article{simko2022-36215904, author = {Šimko, P. and Kent, J. A. and Rektorova, I.}, title = {{Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer's disease? An updated meta-analysis}}, journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology}, year = {2022}, doi = {10.1016/j.clinph.2022.09.010}, pmid = {36215904}, url = {https://doi.org/10.1016/j.clinph.2022.09.010} } @article{papaioannou2022-35811514, author = {Papaioannou, T. and Voinescu, A. and Petrini, K. and Stanton Fraser, D.}, title = {{Efficacy and Moderators of Virtual Reality for Cognitive Training in People with Dementia and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2022}, doi = {10.3233/jad-210672}, pmid = {35811514}, url = {https://doi.org/10.3233/jad-210672} } @article{gomezsoria2022-35839574, author = {Gómez-Soria, I. and Marin-Puyalto, J. and Peralta-Marrupe, P. and Latorre, E. and Calatayud, E.}, title = {{Effects of multi-component non-pharmacological interventions on cognition in participants with mild cognitive impairment: A systematic review and meta-analysis}}, journal = {Archives of gerontology and geriatrics}, year = {2022}, doi = {10.1016/j.archger.2022.104751}, pmid = {35839574}, url = {https://doi.org/10.1016/j.archger.2022.104751} } @article{scholzeldorenbos2007-17545745, author = {Schölzel-Dorenbos, C. J. and van der Steen, M. J. and Engels, L. K. and Olde Rikkert, M. G.}, title = {{Assessment of quality of life as outcome in dementia and MCI intervention trials: a systematic review}}, journal = {Alzheimer disease and associated disorders}, year = {2007}, doi = {10.1097/wad.0b013e318047df4c}, pmid = {17545745}, url = {https://doi.org/10.1097/wad.0b013e318047df4c} } @article{shi2009-19309039, author = {Shi, F. and Liu, B. and Zhou, Y. and Yu, C. and Jiang, T.}, title = {{Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies}}, journal = {Hippocampus}, year = {2009}, doi = {10.1002/hipo.20573}, pmid = {19309039}, url = {https://doi.org/10.1002/hipo.20573} } @article{garrett2019-31834392, author = {Garrett, S. L. and McDaniel, D. and Obideen, M. and Trammell, A. R. and Shaw, L. M. and Goldstein, F. C. and Hajjar, I.}, title = {{Racial Disparity in Cerebrospinal Fluid Amyloid and Tau Biomarkers and Associated Cutoffs for Mild Cognitive Impairment}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.17363}, pmid = {31834392}, url = {https://doi.org/10.1001/jamanetworkopen.2019.17363} } @article{qu2021-34245759, author = {Qu, Y. and Ma, Y. H. and Huang, Y. Y. and Ou, Y. N. and Shen, X. N. and Chen, S. D. and Dong, Q. and Tan, L. and others}, title = {{Blood biomarkers for the diagnosis of amnestic mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis}}, journal = {Neuroscience and biobehavioral reviews}, year = {2021}, doi = {10.1016/j.neubiorev.2021.07.007}, pmid = {34245759}, url = {https://doi.org/10.1016/j.neubiorev.2021.07.007} } @article{casanova2016-26806385, author = {Casanova, R. and Varma, S. and Simpson, B. and Kim, M. and An, Y. and Saldana, S. and Riveros, C. and Moscato, P. and others}, title = {{Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2016}, doi = {10.1016/j.jalz.2015.12.008}, pmid = {26806385}, url = {https://doi.org/10.1016/j.jalz.2015.12.008} } @article{yakoub2023-37294682, author = {Yakoub, Y. and Ashton, N. J. and Strikwerda-Brown, C. and Montoliu-Gaya, L. and Karikari, T. K. and Kac, P. R. and Gonzalez-Ortiz, F. and Gallego-Rudolf, J. and others}, title = {{Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2023}, doi = {10.1002/alz.13318}, pmid = {37294682}, url = {https://doi.org/10.1002/alz.13318} } @article{raman2021-34228129, author = {Raman, R. and Quiroz, Y. T. and Langford, O. and Choi, J. and Ritchie, M. and Baumgartner, M. and Rentz, D. and Aggarwal, N. T. and others}, title = {{Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial}}, journal = {JAMA network open}, year = {2021}, doi = {10.1001/jamanetworkopen.2021.14364}, pmid = {34228129}, url = {https://doi.org/10.1001/jamanetworkopen.2021.14364} } @article{verghese2006-16467493, author = {Verghese, J. and LeValley, A. and Derby, C. and Kuslansky, G. and Katz, M. and Hall, C. and Buschke, H. and Lipton, R. B.}, title = {{Leisure activities and the risk of amnestic mild cognitive impairment in the elderly}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000202520.68987.48}, pmid = {16467493}, url = {https://doi.org/10.1212/01.wnl.0000202520.68987.48} } @article{summers2012-22612573, author = {Summers, Mathew James and Saunders, Nichole L.}, title = {{Neuropsychological measures predict decline to Alzheimer's dementia from mild cognitive impairment}}, journal = {Neuropsychology}, year = {2012}, doi = {10.1037/a0028576}, pmid = {22612573}, url = {https://doi.org/10.1037/a0028576} } @article{martinoadami2022-35088840, author = {Martino Adami, P. V. and Orellana, A. and García, P. and Kleineidam, L. and Alarcón-Martín, E. and Montrreal, L. and Aguilera, N. and Espinosa, A. and others}, title = {{Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type}}, journal = {Brain : a journal of neurology}, year = {2022}, doi = {10.1093/brain/awac024}, pmid = {35088840}, url = {https://doi.org/10.1093/brain/awac024} } @article{alty2022-35850660, author = {Alty, J. and Bai, Q. and Li, R. and Lawler, K. and St George, R. J. and Hill, E. and Bindoff, A. and Garg, S. and others}, title = {{The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer's disease and estimate 5-year risks of cognitive decline and dementia}}, journal = {BMC neurology}, year = {2022}, doi = {10.1186/s12883-022-02772-5}, pmid = {35850660}, url = {https://doi.org/10.1186/s12883-022-02772-5} } @article{melville2025-41448220, author = {Melville, M. and He, L. and Desai, R. and Nyamayaro, P. and Fox, C. and Kothari, K. U. and Condron, P. and Miao, M. and Hickey, M. and Spector, A.}, title = {{Menopause hormone therapy and risk of mild cognitive impairment or dementia: a systematic review and meta-analysis}}, journal = {The Lancet Healthy Longevity}, year = {2025}, doi = {10.1016/j.lanhl.2025.100803}, pmid = {41448220}, url = {https://doi.org/10.1016/j.lanhl.2025.100803} } @article{rowe2007-17502554, author = {Rowe, C. C. and Ng, S. and Ackermann, U. and Gong, S. J. and Pike, K. and Savage, G. and Cowie, T. F. and Dickinson, K. L. and others}, title = {{Imaging beta-amyloid burden in aging and dementia}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000261919.22630.ea}, pmid = {17502554}, url = {https://doi.org/10.1212/01.wnl.0000261919.22630.ea} } @article{buckley2019-30715078, author = {Buckley, R. F. and Mormino, E. C. and Rabin, J. S. and Hohman, T. J. and Landau, S. and Hanseeuw, B. J. and Jacobs, H. I. L. and Papp, K. V. and others}, title = {{Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults}}, journal = {JAMA neurology}, year = {2019}, doi = {10.1001/jamaneurol.2018.4693}, pmid = {30715078}, url = {https://doi.org/10.1001/jamaneurol.2018.4693} } @article{clare2010-20808145, author = {Clare, L. and Linden, D. E. and Woods, R. T. and Whitaker, R. and Evans, S. J. and Parkinson, C. H. and van Paasschen, J. and Nelis, S. M. and others}, title = {{Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2010}, doi = {10.1097/jgp.0b013e3181d5792a}, pmid = {20808145}, url = {https://doi.org/10.1097/jgp.0b013e3181d5792a} } @article{vandepol2007-17620494, author = {van de Pol, L. A. and Korf, E. S. and van der Flier, W. M. and Brashear, H. R. and Fox, N. C. and Barkhof, F. and Scheltens, P.}, title = {{Magnetic resonance imaging predictors of cognition in mild cognitive impairment}}, journal = {Archives of neurology}, year = {2007}, doi = {10.1001/archneur.64.7.1023}, pmid = {17620494}, url = {https://doi.org/10.1001/archneur.64.7.1023} } @article{vidoni2019-29286983, author = {Vidoni, E. D. and Perales, J. and Alshehri, M. and Giles, A. M. and Siengsukon, C. F. and Burns, J. M.}, title = {{Aerobic Exercise Sustains Performance of Instrumental Activities of Daily Living in Early-Stage Alzheimer Disease}}, journal = {Journal of geriatric physical therapy (2001)}, year = {2019}, doi = {10.1519/jpt.0000000000000172}, pmid = {29286983}, url = {https://doi.org/10.1519/jpt.0000000000000172} } @article{ellis2019-29059120, author = {Ellis, J. L. and Altenburger, P. and Lu, Y.}, title = {{Change in Depression, Confidence, and Physical Function Among Older Adults With Mild Cognitive Impairment}}, journal = {Journal of geriatric physical therapy (2001)}, year = {2019}, doi = {10.1519/jpt.0000000000000143}, pmid = {29059120}, url = {https://doi.org/10.1519/jpt.0000000000000143} } @article{cooper2015-25698435, author = {Cooper, C. and Sommerlad, A. and Lyketsos, C. G. and Livingston, G.}, title = {{Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis}}, journal = {The American journal of psychiatry}, year = {2015}, doi = {10.1176/appi.ajp.2014.14070878}, pmid = {25698435}, url = {https://doi.org/10.1176/appi.ajp.2014.14070878} } @article{sinn2012-21929835, author = {Sinn, N. and Milte, C. M. and Street, S. J. and Buckley, J. D. and Coates, A. M. and Petkov, J. and Howe, P. R.}, title = {{Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial}}, journal = {The British journal of nutrition}, year = {2012}, doi = {10.1017/s0007114511004788}, pmid = {21929835}, url = {https://doi.org/10.1017/s0007114511004788} } @article{song2019-30901716, author = {Song, D. and Yu, D. S. F.}, title = {{Effects of a moderate-intensity aerobic exercise programme on the cognitive function and quality of life of community-dwelling elderly people with mild cognitive impairment: A randomised controlled trial}}, journal = {International journal of nursing studies}, year = {2019}, doi = {10.1016/j.ijnurstu.2019.02.019}, pmid = {30901716}, url = {https://doi.org/10.1016/j.ijnurstu.2019.02.019} } @article{risacher2009-19689234, author = {Risacher, S. L. and Saykin, A. J. and West, J. D. and Shen, L. and Firpi, H. A. and McDonald, B. C.}, title = {{Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort}}, journal = {Current Alzheimer research}, year = {2009}, doi = {10.2174/156720509788929273}, pmid = {19689234}, url = {https://doi.org/10.2174/156720509788929273} } @article{buckley2017-28592457, author = {Buckley, R. F. and Schultz, A. P. and Hedden, T. and Papp, K. V. and Hanseeuw, B. J. and Marshall, G. and Sepulcre, J. and Smith, E. E. and others}, title = {{Functional network integrity presages cognitive decline in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004059}, pmid = {28592457}, url = {https://doi.org/10.1212/wnl.0000000000004059} } @article{jessen2014-23375567, author = {Jessen, F. and Wolfsgruber, S. and Wiese, B. and Bickel, H. and Mösch, E. and Kaduszkiewicz, H. and Pentzek, M. and Riedel-Heller, S. G. and others}, title = {{AD dementia risk in late MCI, in early MCI, and in subjective memory impairment}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2014}, doi = {10.1016/j.jalz.2012.09.017}, pmid = {23375567}, url = {https://doi.org/10.1016/j.jalz.2012.09.017} } @article{lopez2003-14568809, author = {Lopez, O. L. and Jagust, W. J. and Dulberg, C. and Becker, J. T. and DeKosky, S. T. and Fitzpatrick, A. and Breitner, J. and Lyketsos, C. and others}, title = {{Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2}}, journal = {Archives of neurology}, year = {2003}, doi = {10.1001/archneur.60.10.1394}, pmid = {14568809}, url = {https://doi.org/10.1001/archneur.60.10.1394} } @article{james2021-34913981, author = {James, C. and Ranson, J. M. and Everson, R. and Llewellyn, D. J.}, title = {{Performance of Machine Learning Algorithms for Predicting Progression to Dementia in Memory Clinic Patients}}, journal = {JAMA network open}, year = {2021}, doi = {10.1001/jamanetworkopen.2021.36553}, pmid = {34913981}, url = {https://doi.org/10.1001/jamanetworkopen.2021.36553} } @article{petersen2014-24605806, author = {Petersen, R. C. and Caracciolo, B. and Brayne, C. and Gauthier, S. and Jelic, V. and Fratiglioni, L.}, title = {{Mild cognitive impairment: a concept in evolution}}, journal = {Journal of internal medicine}, year = {2014}, doi = {10.1111/joim.12190}, pmid = {24605806}, url = {https://doi.org/10.1111/joim.12190} } @article{berron2020-32252068, author = {Berron, D. and van Westen, D. and Ossenkoppele, R. and Strandberg, O. and Hansson, O.}, title = {{Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2020}, doi = {10.1093/brain/awaa068}, pmid = {32252068}, url = {https://doi.org/10.1093/brain/awaa068} } @article{lee2019-30760848, author = {Lee, G. and Nho, K. and Kang, B. and Sohn, K. A. and Kim, D. and {for Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Predicting Alzheimer's disease progression using multi-modal deep learning approach}}, journal = {Scientific reports}, year = {2019}, doi = {10.1038/s41598-018-37769-z}, pmid = {30760848}, url = {https://doi.org/10.1038/s41598-018-37769-z} } @article{fowler2021-34368630, author = {Fowler, C. and Rainey-Smith, SR. and Bird, S. and Bomke, J. and Bourgeat, P. and Brown, B. M. and Burnham, S. C. and Bush, A. I. and others}, title = {{Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease}}, journal = {Journal of Alzheimer's disease reports}, year = {2021}, doi = {10.3233/adr-210005}, pmid = {34368630}, url = {https://doi.org/10.3233/adr-210005} } @article{toledo2011-21805181, author = {Toledo, J. B. and Vanderstichele, H. and Figurski, M. and Aisen, P. S. and Petersen, R. C. and Weiner, M. W. and Jack, C. R. and Jagust, W. and others}, title = {{Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI}}, journal = {Acta neuropathologica}, year = {2011}, doi = {10.1007/s00401-011-0861-8}, pmid = {21805181}, url = {https://doi.org/10.1007/s00401-011-0861-8} } @article{wang2016-27010616, author = {Wang, J. and Logovinsky, V. and Hendrix, S. B. and Stanworth, S. H. and Perdomo, C. and Xu, L. and Dhadda, S. and Do, I. and others}, title = {{ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials}}, journal = {Journal of neurology, neurosurgery, and psychiatry}, year = {2016}, doi = {10.1136/jnnp-2015-312383}, pmid = {27010616}, url = {https://doi.org/10.1136/jnnp-2015-312383} } @article{sosa2012-22346736, author = {Sosa, A. L. and Albanese, E. and Stephan, B. C. and Dewey, M. and Acosta, D. and Ferri, C. P. and Guerra, M. and Huang, Y. and others}, title = {{Prevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: a 10/66 population-based study}}, journal = {PLoS medicine}, year = {2012}, doi = {10.1371/journal.pmed.1001170}, pmid = {22346736}, url = {https://doi.org/10.1371/journal.pmed.1001170} } @article{ghahremani2023-36323521, author = {Ghahremani, M. and Wang, M. and Chen, H. Y. and Zetterberg, H. and Smith, E. and Ismail, Z. and {Alzheimer's Disease Neuroimaging Initiative*}}, title = {{Plasma Phosphorylated Tau at Threonine 181 and Neuropsychiatric Symptoms in Preclinical and Prodromal Alzheimer Disease}}, journal = {Neurology}, year = {2023}, doi = {10.1212/wnl.0000000000201517}, pmid = {36323521}, url = {https://doi.org/10.1212/wnl.0000000000201517} } @article{yu2025-39835654, author = {Yu, Ruan‐Ching and Pavlou, Menelaos and Schilder, Anne GM and Bamiou, Doris‐Eva and Lewis, Glyn and Lin, Frank Robert and Livingston, Gill and Proctor, Danielle and others}, title = {{Early detection and management of hearing loss to reduce dementia risk in older adults with mild cognitive impairment: findings from the treating auditory impairment and cognition trial (TACT)}}, journal = {Age and Ageing}, year = {2025}, doi = {10.1093/ageing/afaf004}, pmid = {39835654}, url = {https://doi.org/10.1093/ageing/afaf004} } @article{moon2025-39840755, author = {Moon, So Young and Park, Yoo Kyoung and Jeong, Jee Hyang and Hong, Chang Hyung and Jung, Jiwoo and Na, Hae Ri and Cho, Soo Hyun and Kim, Hyun Sook and others}, title = {{South Korean study to prevent cognitive impairment and protect brain health through multidomain interventions via face‐to‐face and video communication platforms in mild cognitive impairment (SUPERBRAIN‐MEET): A randomized controlled trial}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.14517}, pmid = {39840755}, url = {https://doi.org/10.1002/alz.14517} } @article{jack1999-10227624, author = {Jack, Clifford R. and Petersen, Ronald and Xu, Yun and O’Brien, Peter C. and Smith, Glenn E. and Ivnik, Robert J. and Boeve, Bradley F. and Waring, Stephen C. and others}, title = {{Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment}}, journal = {Neurology}, year = {1999}, doi = {10.1212/wnl.52.7.1397}, pmid = {10227624}, url = {https://doi.org/10.1212/wnl.52.7.1397} } @article{hill2017-27838936, author = {Hill, N. T. and Mowszowski, L. and Naismith, S. L. and Chadwick, V. L. and Valenzuela, M. and Lampit, A.}, title = {{Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis}}, journal = {The American journal of psychiatry}, year = {2017}, doi = {10.1176/appi.ajp.2016.16030360}, pmid = {27838936}, url = {https://doi.org/10.1176/appi.ajp.2016.16030360} } @article{yang2020-31697831, author = {Yang, C. and Moore, A. and Mpofu, E. and Dorstyn, D. and Li, Q. and Yin, C.}, title = {{Effectiveness of Combined Cognitive and Physical Interventions to Enhance Functioning in Older Adults With Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials}}, journal = {The Gerontologist}, year = {2020}, doi = {10.1093/geront/gnz149}, pmid = {31697831}, url = {https://doi.org/10.1093/geront/gnz149} } @article{whitty2020-32534025, author = {Whitty, E. and Mansour, H. and Aguirre, E. and Palomo, M. and Charlesworth, G. and Ramjee, S. and Poppe, M. and Brodaty, H. and others}, title = {{Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review}}, journal = {Ageing research reviews}, year = {2020}, doi = {10.1016/j.arr.2020.101113}, pmid = {32534025}, url = {https://doi.org/10.1016/j.arr.2020.101113} } @article{nousia2021-31885287, author = {Nousia, A. and Martzoukou, M. and Siokas, V. and Aretouli, E. and Aloizou, A. M. and Folia, V. and Peristeri, E. and Messinis, L. and others}, title = {{Beneficial effect of computer-based multidomain cognitive training in patients with mild cognitive impairment}}, journal = {Applied neuropsychology. Adult}, year = {2021}, doi = {10.1080/23279095.2019.1692842}, pmid = {31885287}, url = {https://doi.org/10.1080/23279095.2019.1692842} } @article{sheng2020-32741806, author = {Sheng, C. and Yang, K. and Wang, X. and Li, H. and Li, T. and Lin, L. and Liu, Y. and Yang, Q. and others}, title = {{Advances in Non-Pharmacological Interventions for Subjective Cognitive Decline: A Systematic Review and Meta-Analysis}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2020}, doi = {10.3233/jad-191295}, pmid = {32741806}, url = {https://doi.org/10.3233/jad-191295} } @article{karssemeijer2017-28912076, author = {Karssemeijer, E. G. A. and Aaronson, J. A. and Bossers, W. J. and Smits, T. and Olde Rikkert, M. G. M. and Kessels, R. P. C.}, title = {{Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis}}, journal = {Ageing research reviews}, year = {2017}, doi = {10.1016/j.arr.2017.09.003}, pmid = {28912076}, url = {https://doi.org/10.1016/j.arr.2017.09.003} } @article{carson2018-28731508, author = {Carson, N. and Leach, L. and Murphy, K. J.}, title = {{A re-examination of Montreal Cognitive Assessment (MoCA) cutoff scores}}, journal = {International journal of geriatric psychiatry}, year = {2018}, doi = {10.1002/gps.4756}, pmid = {28731508}, url = {https://doi.org/10.1002/gps.4756} } @article{kordower2001-11220740, author = {Kordower, J. H. and Chu, Y. and Stebbins, G. T. and DeKosky, S. T. and Cochran, E. J. and Bennett, D. and Mufson, E. J.}, title = {{Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment}}, journal = {Annals of neurology}, year = {2001}, doi = {10.1002/1531-8249(20010201)49:2<202::aid-ana40>3.0.co;2-3}, pmid = {11220740}, url = {https://doi.org/10.1002/1531-8249(20010201)49:2<202::aid-ana40>3.0.co;2-3} } @article{pinto2019-30426911, author = {Pinto, T. C. C. and Machado, L. and Bulgacov, T. M. and Rodrigues-Júnior, A. L. and Costa, M. L. G. and Ximenes, R. C. C. and Sougey, E. B.}, title = {{Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer's Disease (AD) in the elderly?}}, journal = {International psychogeriatrics}, year = {2019}, doi = {10.1017/s1041610218001370}, pmid = {30426911}, url = {https://doi.org/10.1017/s1041610218001370} } @article{radestig2021-33216028, author = {Rådestig, Maya Arvidsson and Skoog, Johan and Zetterberg, Henrik and Kern, Jürgen and Zettergren, Anna and Sacuiu, Simona and Waern, Margda and Wetterberg, Hanna and others}, title = {{Cognitive Performance and Cerebrospinal Fluid Markers in Preclinical Alzheimer's Disease: Results from the Gothenburg H70 Birth Cohort Studies}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2021}, doi = {10.3233/jad-200751}, pmid = {33216028}, url = {https://doi.org/10.3233/jad-200751} } @article{kwon2023-38026758, author = {Kwon, Hyuk Sung and Lee, Eun-Hye and Kim, Hyung-Ji and Park, So-Hee and Park, Hyun-Hee and Jeong, Jee Hyang and Koh, Seong-Ho and Choi, Seong Hye and others}, title = {{Predicting amyloid PET positivity using plasma p-tau181 and other blood-based biomarkers}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2023}, doi = {10.1002/dad2.12502}, pmid = {38026758}, url = {https://doi.org/10.1002/dad2.12502} } @article{murphy2022-36619039, author = {Murphy, Samantha A and Chen, Ling and Doherty, Jason M and Acharyya, Prerana and Riley, Noah and Johnson, Ann M and Walker, Alexis and Domash, Hailee and others}, title = {{Cognitive and brain reserve predict decline in adverse driving behaviors among cognitively normal older adults}}, journal = {Frontiers in psychology}, year = {2022}, doi = {10.3389/fpsyg.2022.1076735}, pmid = {36619039}, url = {https://doi.org/10.3389/fpsyg.2022.1076735} } @article{smith2022-36057392, author = {Smith, Lee and Shin, Jae Il and Sánchez, Guillermo F López and Oh, Hans and Kostev, Karel and Jacob, Louis and Law, Christopher Tejun and Carmichael, Christina and others}, title = {{Social participation and mild cognitive impairment in low- and middle-income countries}}, journal = {Preventive medicine}, year = {2022}, doi = {10.1016/j.ypmed.2022.107230}, pmid = {36057392}, url = {https://doi.org/10.1016/j.ypmed.2022.107230} } @article{rouskas2025-41011443, author = {Rouskas, Konstantinos and Mamalaki, Eirini and Ntanasi, Eva and Pantoura, Marianna and Anezaki, Maria and Emmanouil, Christina and Novau-Ferré, Nil and Bulló, Mònica and others}, title = {{Gut Microbiome Alterations in Mild Cognitive Impairment: Findings from the ALBION Greek Cohort}}, journal = {Microorganisms}, year = {2025}, doi = {10.3390/microorganisms13092112}, pmid = {41011443}, url = {https://doi.org/10.3390/microorganisms13092112} } @article{tangen2022-36028328, author = {Tangen, G. G. and Nilsson, M. H. and Stomrud, E. and Palmqvist, S. and Hansson, O.}, title = {{Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201106}, pmid = {36028328}, url = {https://doi.org/10.1212/wnl.0000000000201106} } @article{mengel2025-40247130, author = {Mengel, D. and Soter, E. and Ott, J. M. and Wacker, M. and Leyva, A. and Peters, O. and Hellmann-Regen, J. and Schneider, L. S. and others}, title = {{Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease}}, journal = {Molecular psychiatry}, year = {2025}, doi = {10.1038/s41380-025-03021-0}, pmid = {40247130}, url = {https://doi.org/10.1038/s41380-025-03021-0} } @article{soldan2025-39724536, author = {Soldan, A. and Pettigrew, C. and Wang, J. and Albert, M. S. and Blennow, K. and Bittner, T. and Moghekar, A.}, title = {{Blood-Based Biomarkers and Risk of Onset of Mild Cognitive Impairment Over the Short and Long Term}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000210225}, pmid = {39724536}, url = {https://doi.org/10.1212/wnl.0000000000210225} } @article{aarsland2017-28257128, author = {Aarsland, D. and Creese, B. and Politis, M. and Chaudhuri, K. R. and Ffytche, D. H. and Weintraub, D. and Ballard, C.}, title = {{Cognitive decline in Parkinson disease}}, journal = {Nature reviews. Neurology}, year = {2017}, doi = {10.1038/nrneurol.2017.27}, pmid = {28257128}, url = {https://doi.org/10.1038/nrneurol.2017.27} } @article{donohue2014-24886908, author = {Donohue, M. C. and Sperling, R. A. and Salmon, D. P. and Rentz, D. M. and Raman, R. and Thomas, R. G. and Weiner, M. and Aisen, P. S. and others}, title = {{The preclinical Alzheimer cognitive composite: measuring amyloid-related decline}}, journal = {JAMA neurology}, year = {2014}, doi = {10.1001/jamaneurol.2014.803}, pmid = {24886908}, url = {https://doi.org/10.1001/jamaneurol.2014.803} } @article{vermunt2019-31164314, author = {Vermunt, L. and Sikkes, S. A. M. and van den Hout, A. and Handels, R. and Bos, I. and van der Flier, W. M. and Kern, S. and Ousset, P. J. and others}, title = {{Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2019.04.001}, pmid = {31164314}, url = {https://doi.org/10.1016/j.jalz.2019.04.001} } @article{mormino2014-24748674, author = {Mormino, E. C. and Betensky, R. A. and Hedden, T. and Schultz, A. P. and Ward, A. and Huijbers, W. and Rentz, D. M. and Johnson, K. A. and others}, title = {{Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000431}, pmid = {24748674}, url = {https://doi.org/10.1212/wnl.0000000000000431} } @article{manly2005-16286549, author = {Manly, J. J. and Bell-McGinty, S. and Tang, M. X. and Schupf, N. and Stern, Y. and Mayeux, R.}, title = {{Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community}}, journal = {Archives of neurology}, year = {2005}, doi = {10.1001/archneur.62.11.1739}, pmid = {16286549}, url = {https://doi.org/10.1001/archneur.62.11.1739} } @article{pietrzak2015-25629787, author = {Pietrzak, R. H. and Lim, Y. Y. and Neumeister, A. and Ames, D. and Ellis, K. A. and Harrington, K. and Lautenschlager, N. T. and Restrepo, C. and others}, title = {{Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study}}, journal = {JAMA psychiatry}, year = {2015}, doi = {10.1001/jamapsychiatry.2014.2476}, pmid = {25629787}, url = {https://doi.org/10.1001/jamapsychiatry.2014.2476} } @article{goekoop2004-15589109, author = {Goekoop, R. and Rombouts, S. A. and Jonker, C. and Hibbel, A. and Knol, D. L. and Truyen, L. and Barkhof, F. and Scheltens, P.}, title = {{Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study}}, journal = {NeuroImage}, year = {2004}, doi = {10.1016/j.neuroimage.2004.08.006}, pmid = {15589109}, url = {https://doi.org/10.1016/j.neuroimage.2004.08.006} } @article{tenbrinke2015-24711660, author = {ten Brinke, L. F. and Bolandzadeh, N. and Nagamatsu, L. S. and Hsu, C. L. and Davis, J. C. and Miran-Khan, K. and Liu-Ambrose, T.}, title = {{Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial}}, journal = {British journal of sports medicine}, year = {2015}, doi = {10.1136/bjsports-2013-093184}, pmid = {24711660}, url = {https://doi.org/10.1136/bjsports-2013-093184} } @article{geda2010-20065133, author = {Geda, Y. E. and Roberts, R. O. and Knopman, D. S. and Christianson, T. J. and Pankratz, V. S. and Ivnik, R. J. and Boeve, B. F. and Tangalos, E. G. and others}, title = {{Physical exercise, aging, and mild cognitive impairment: a population-based study}}, journal = {Archives of neurology}, year = {2010}, doi = {10.1001/archneurol.2009.297}, pmid = {20065133}, url = {https://doi.org/10.1001/archneurol.2009.297} } @article{mitchell2009-18579155, author = {Mitchell, A. J.}, title = {{A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment}}, journal = {Journal of psychiatric research}, year = {2009}, doi = {10.1016/j.jpsychires.2008.04.014}, pmid = {18579155}, url = {https://doi.org/10.1016/j.jpsychires.2008.04.014} } @article{trzepacz2015-26346644, author = {Trzepacz, P. T. and Hochstetler, H. and Wang, S. and Walker, B. and Saykin, A. J. and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults}}, journal = {BMC geriatrics}, year = {2015}, doi = {10.1186/s12877-015-0103-3}, pmid = {26346644}, url = {https://doi.org/10.1186/s12877-015-0103-3} } @article{grober2008-18282324, author = {Grober, E. and Hall, C. B. and Lipton, R. B. and Zonderman, A. B. and Resnick, S. M. and Kawas, C.}, title = {{Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease}}, journal = {Journal of the International Neuropsychological Society : JINS}, year = {2008}, doi = {10.1017/s1355617708080302}, pmid = {18282324}, url = {https://doi.org/10.1017/s1355617708080302} } @article{petrella2011-21228297, author = {Petrella, JR. and Sheldon, F. C. and Prince, S. E. and Calhoun, V. D. and Doraiswamy, P. M.}, title = {{Default mode network connectivity in stable vs progressive mild cognitive impairment}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e31820af94e}, pmid = {21228297}, url = {https://doi.org/10.1212/wnl.0b013e31820af94e} } @article{soldan2020-31888969, author = {Soldan, A. and Pettigrew, C. and Zhu, Y. and Wang, M. C. and Moghekar, A. and Gottesman, R. F. and Singh, B. and Martinez, O. and others}, title = {{White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000008864}, pmid = {31888969}, url = {https://doi.org/10.1212/wnl.0000000000008864} } @article{vandepol2007-17923611, author = {van de Pol, L. A. and van der Flier, W. M. and Korf, E. S. and Fox, N. C. and Barkhof, F. and Scheltens, P.}, title = {{Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000277458.26846.96}, pmid = {17923611}, url = {https://doi.org/10.1212/01.wnl.0000277458.26846.96} } @article{gunak2021-33760039, author = {Günak, M. M. and Barnes, D. E. and Yaffe, K. and Li, Y. and Byers, A. L.}, title = {{Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia}}, journal = {JAMA psychiatry}, year = {2021}, doi = {10.1001/jamapsychiatry.2021.0150}, pmid = {33760039}, url = {https://doi.org/10.1001/jamapsychiatry.2021.0150} } @article{aarsland2010-20855849, author = {Aarsland, D. and Bronnick, K. and Williams-Gray, C. and Weintraub, D. and Marder, K. and Kulisevsky, J. and Burn, D. and Barone, P. and others}, title = {{Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181f39d0e}, pmid = {20855849}, url = {https://doi.org/10.1212/wnl.0b013e3181f39d0e} } @article{amieva2008-19067364, author = {Amieva, H. and Le Goff, M. and Millet, X. and Orgogozo, J. M. and Pérès, K. and Barberger-Gateau, P. and Jacqmin-Gadda, H. and Dartigues, J. F.}, title = {{Prodromal Alzheimer's disease: successive emergence of the clinical symptoms}}, journal = {Annals of neurology}, year = {2008}, doi = {10.1002/ana.21509}, pmid = {19067364}, url = {https://doi.org/10.1002/ana.21509} } @article{tranah2011-22162057, author = {Tranah, G. J. and Blackwell, T. and Stone, K. L. and Ancoli-Israel, S. and Paudel, M. L. and Ensrud, K. E. and Cauley, J. A. and Redline, S. and others}, title = {{Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22468}, pmid = {22162057}, url = {https://doi.org/10.1002/ana.22468} } @article{grueso2021-34583745, author = {Grueso, S. and Viejo-Sobera, R.}, title = {{Machine learning methods for predicting progression from mild cognitive impairment to Alzheimer's disease dementia: a systematic review}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00900-w}, pmid = {34583745}, url = {https://doi.org/10.1186/s13195-021-00900-w} } @article{watson2005-16286438, author = {Watson, G. S. and Cholerton, B. A. and Reger, M. A. and Baker, L. D. and Plymate, SR. and Asthana, S. and Fishel, M. A. and Kulstad, J. J. and others}, title = {{Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2005}, doi = {10.1176/appi.ajgp.13.11.950}, pmid = {16286438}, url = {https://doi.org/10.1176/appi.ajgp.13.11.950} } @article{yaffe2006-16940725, author = {Yaffe, K. and Petersen, R. C. and Lindquist, K. and Kramer, J. and Miller, B.}, title = {{Subtype of mild cognitive impairment and progression to dementia and death}}, journal = {Dementia and geriatric cognitive disorders}, year = {2006}, doi = {10.1159/000095427}, pmid = {16940725}, url = {https://doi.org/10.1159/000095427} } @article{kester2015-26366630, author = {Kester, M. I. and Teunissen, C. E. and Crimmins, D. L. and Herries, E. M. and Ladenson, J. H. and Scheltens, P. and van der Flier, W. M. and Morris, J. C. and others}, title = {{Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease}}, journal = {JAMA neurology}, year = {2015}, doi = {10.1001/jamaneurol.2015.1867}, pmid = {26366630}, url = {https://doi.org/10.1001/jamaneurol.2015.1867} } @article{ng2016-26926205, author = {Ng, T. P. and Feng, L. and Nyunt, M. S. and Gao, Q. and Lim, M. L. and Collinson, S. L. and Chong, M. S. and others}, title = {{Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2015.4899}, pmid = {26926205}, url = {https://doi.org/10.1001/jamaneurol.2015.4899} } @article{hua2010-20620666, author = {Hua, X. and Hibar, D. P. and Lee, S. and Toga, A. W. and Jack, C. R. and Weiner, M. W. and Thompson, P. M. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans}}, journal = {Neurobiology of aging}, year = {2010}, doi = {10.1016/j.neurobiolaging.2010.04.033}, pmid = {20620666}, url = {https://doi.org/10.1016/j.neurobiolaging.2010.04.033} } @article{dong2017-28003242, author = {Dong, A. and Toledo, J. B. and Honnorat, N. and Doshi, J. and Varol, E. and Sotiras, A. and Wolk, D. and Trojanowski, J. Q. and others}, title = {{Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers}}, journal = {Brain : a journal of neurology}, year = {2017}, doi = {10.1093/brain/aww319}, pmid = {28003242}, url = {https://doi.org/10.1093/brain/aww319} } @article{biel2021-34384484, author = {Biel, D. and Brendel, M. and Rubinski, A. and Buerger, K. and Janowitz, D. and Dichgans, M. and Franzmeier, N.}, title = {{Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals}}, journal = {Alzheimer's research \& therapy}, year = {2021}, doi = {10.1186/s13195-021-00880-x}, pmid = {34384484}, url = {https://doi.org/10.1186/s13195-021-00880-x} } @article{leung2013-23762274, author = {Leung, R. and Proitsi, P. and Simmons, A. and Lunnon, K. and Güntert, A. and Kronenberg, D. and Pritchard, M. and Tsolaki, M. and others}, title = {{Inflammatory proteins in plasma are associated with severity of Alzheimer's disease}}, journal = {PloS one}, year = {2013}, doi = {10.1371/journal.pone.0064971}, pmid = {23762274}, url = {https://doi.org/10.1371/journal.pone.0064971} } @article{mielke2017-28692710, author = {Mielke, M. M. and Hagen, C. E. and Wennberg, A. M. V. and Airey, D. C. and Savica, R. and Knopman, D. S. and Machulda, M. M. and Roberts, R. O. and others}, title = {{Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.1359}, pmid = {28692710}, url = {https://doi.org/10.1001/jamaneurol.2017.1359} } @article{wang2022-36150665, author = {Wang, L. and Zhang, J. and Guo, C. and He, J. and Zhang, S. and Wang, Y. and Zhao, Y. and Li, L. and others}, title = {{The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial}}, journal = {Brain stimulation}, year = {2022}, doi = {10.1016/j.brs.2022.09.003}, pmid = {36150665}, url = {https://doi.org/10.1016/j.brs.2022.09.003} } @article{noor2025-39969227, author = {Noor, Al-Hammadi and Mahmoud, Abouelyazid and Brown David, C. and Pooja, Lalwani and Hannes, Devos and Carr David, B. and Babulal Ganesh, M.}, title = {{Integrating Machine Learning and Environmental and Genetic Risk Factors for the Early Detection of Preclinical Alzheimer's Disease}}, journal = {The journals of gerontology. Series B, Psychological sciences and social sciences}, year = {2025}, doi = {10.1093/geronb/gbaf023}, pmid = {39969227}, url = {https://doi.org/10.1093/geronb/gbaf023} } @article{cousins2025-40801297, author = {Cousins, K. A. Q. and Korecka, M. and Wan, Y. and Vulaj, A. and Brown, C. and Tropea, T. F. and Lee, E. B. and Tosun, D. and Landau, S. M. and Okonkwo, O. C. and Mindt, M. R. and Weiner, M. W. and others}, title = {{Comparison of plasma p-tau217/Aβ42, p-tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease}}, journal = {Alzheimer's \& Dementia}, year = {2025}, doi = {10.1002/alz.70469}, pmid = {40801297}, url = {https://doi.org/10.1002/alz.70469} } @article{ebenau2020-32522798, author = {Ebenau, J. L. and Timmers, T. and Wesselman, L. M. P. and Verberk, I. M. W. and Verfaillie, S. C. J. and Slot, R. E. R. and van Harten, A. C. and Teunissen, C. E. and others}, title = {{ATN classification and clinical progression in subjective cognitive decline: The SCIENCe project}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009724}, pmid = {32522798}, url = {https://doi.org/10.1212/wnl.0000000000009724} } @article{long2022-35867858, author = {Long, J. M. and Coble, D. W. and Xiong, C. and Schindler, S. E. and Perrin, R. J. and Gordon, B. A. and Benzinger, T. L. S. and Grant, E. and others}, title = {{Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes}}, journal = {Brain : a journal of neurology}, year = {2022}, doi = {10.1093/brain/awac250}, pmid = {35867858}, url = {https://doi.org/10.1093/brain/awac250} } @article{trieu2025-41335440, author = {Trieu, C. and van Harten, A. C. and van Leeuwenstijn, M. S. S. A. and Schlüter, L. M. and Boonkamp, L. and Aladdin, A. and Sikkes, S. A. M. and van de Giessen, E. and others}, title = {{Longitudinal Blood-Based Biomarkers and Clinical Progression in Subjective Cognitive Decline}}, journal = {JAMA network open}, year = {2025}, doi = {10.1001/jamanetworkopen.2025.45862}, pmid = {41335440}, url = {https://doi.org/10.1001/jamanetworkopen.2025.45862} } @article{kamagata2022-36123122, author = {Kamagata, K. and Andica, C. and Takabayashi, K. and Saito, Y. and Taoka, T. and Nozaki, H. and Kikuta, J. and Fujita, S. and others}, title = {{Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000201300}, pmid = {36123122}, url = {https://doi.org/10.1212/wnl.0000000000201300} } @article{squitti2014-24623259, author = {Squitti, R. and Ghidoni, R. and Siotto, M. and Ventriglia, M. and Benussi, L. and Paterlini, A. and Magri, M. and Binetti, G. and others}, title = {{Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease}}, journal = {Annals of neurology}, year = {2014}, doi = {10.1002/ana.24136}, pmid = {24623259}, url = {https://doi.org/10.1002/ana.24136} } @article{friedman2013-23689947, author = {Friedman, S. D. and Baker, L. D. and Borson, S. and Jensen, J. E. and Barsness, S. M. and Craft, S. and Merriam, G. R. and Otto, R. K. and others}, title = {{Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.1425}, pmid = {23689947}, url = {https://doi.org/10.1001/jamaneurol.2013.1425} } @article{forcano2025-40664536, author = {Forcano, L. and Soldevila-Domenech, N. and Boronat, A. and Sánchez-Benavides, G. and Puig-Pijoan, A. and Lorenzo, T. and Aldea-Perona, A. and Suárez-Calvet, M. and others}, title = {{A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study)}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100271}, pmid = {40664536}, url = {https://doi.org/10.1016/j.tjpad.2025.100271} } @article{vanderlip2026-41653883, author = {Vanderlip, C. R. and Gillen, D. L. and Grill, J. D. and Stark, C. E. L.}, title = {{Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer's trials}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2026}, doi = {10.1016/j.tjpad.2026.100503}, pmid = {41653883}, url = {https://doi.org/10.1016/j.tjpad.2026.100503} } @article{gauthier2006-16631882, author = {Gauthier, S. and Reisberg, B. and Zaudig, M. and Petersen, R. C. and Ritchie, K. and Broich, K. and Belleville, S. and Brodaty, H. and others}, title = {{Mild cognitive impairment}}, journal = {Lancet (London, England)}, year = {2006}, doi = {10.1016/s0140-6736(06)68542-5}, pmid = {16631882}, url = {https://doi.org/10.1016/s0140-6736(06)68542-5} } @article{biazussehn2020-32460123, author = {Biazus-Sehn, L. F. and Schuch, F. B. and Firth, J. and Stigger, F. S.}, title = {{Effects of physical exercise on cognitive function of older adults with mild cognitive impairment: A systematic review and meta-analysis}}, journal = {Archives of gerontology and geriatrics}, year = {2020}, doi = {10.1016/j.archger.2020.104048}, pmid = {32460123}, url = {https://doi.org/10.1016/j.archger.2020.104048} } @article{sachdev2013-23544083, author = {Sachdev, P. S. and Lipnicki, D. M. and Crawford, J. and Reppermund, S. and Kochan, N. A. and Trollor, J. N. and Wen, W. and Draper, B. and others}, title = {{Factors predicting reversion from mild cognitive impairment to normal cognitive functioning: a population-based study}}, journal = {PloS one}, year = {2013}, doi = {10.1371/journal.pone.0059649}, pmid = {23544083}, url = {https://doi.org/10.1371/journal.pone.0059649} } @article{mckeith2020-32241955, author = {McKeith, I. G. and Ferman, T. J. and Thomas, A. J. and Blanc, F. and Boeve, B. F. and Fujishiro, H. and Kantarci, K. and Muscio, C. and others}, title = {{Research criteria for the diagnosis of prodromal dementia with Lewy bodies}}, journal = {Neurology}, year = {2020}, doi = {10.1212/wnl.0000000000009323}, pmid = {32241955}, url = {https://doi.org/10.1212/wnl.0000000000009323} } @article{dickerson2011-21490323, author = {Dickerson, B. C. and Stoub, T. R. and Shah, R. C. and Sperling, R. A. and Killiany, R. J. and Albert, M. S. and Hyman, B. T. and Blacker, D. and others}, title = {{Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults}}, journal = {Neurology}, year = {2011}, doi = {10.1212/wnl.0b013e3182166e96}, pmid = {21490323}, url = {https://doi.org/10.1212/wnl.0b013e3182166e96} } @article{fereshtehnejad2019-31111143, author = {Fereshtehnejad, S. M. and Yao, C. and Pelletier, A. and Montplaisir, J. Y. and Gagnon, J. F. and Postuma, R. B.}, title = {{Evolution of prodromal Parkinson's disease and dementia with Lewy bodies: a prospective study}}, journal = {Brain : a journal of neurology}, year = {2019}, doi = {10.1093/brain/awz111}, pmid = {31111143}, url = {https://doi.org/10.1093/brain/awz111} } @article{bahureksa2017-27172932, author = {Bahureksa, L. and Najafi, B. and Saleh, A. and Sabbagh, M. and Coon, D. and Mohler, M. J. and Schwenk, M.}, title = {{The Impact of Mild Cognitive Impairment on Gait and Balance: A Systematic Review and Meta-Analysis of Studies Using Instrumented Assessment}}, journal = {Gerontology}, year = {2017}, doi = {10.1159/000445831}, pmid = {27172932}, url = {https://doi.org/10.1159/000445831} } @article{wilson2011-21403020, author = {Wilson, R. S. and Leurgans, S. E. and Boyle, P. A. and Bennett, D. A.}, title = {{Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment}}, journal = {Archives of neurology}, year = {2011}, doi = {10.1001/archneurol.2011.31}, pmid = {21403020}, url = {https://doi.org/10.1001/archneurol.2011.31} } @article{devanand2007-17353470, author = {Devanand, D. P. and Pradhaban, G. and Liu, X. and Khandji, A. and De Santi, S. and Segal, S. and Rusinek, H. and Pelton, G. H. and others}, title = {{Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease}}, journal = {Neurology}, year = {2007}, doi = {10.1212/01.wnl.0000256697.20968.d7}, pmid = {17353470}, url = {https://doi.org/10.1212/01.wnl.0000256697.20968.d7} } @article{vlassenko2016-27398953, author = {Vlassenko, A. G. and McCue, L. and Jasielec, M. S. and Su, Y. and Gordon, B. A. and Xiong, C. and Holtzman, D. M. and Benzinger, T. L. and others}, title = {{Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease}}, journal = {Annals of neurology}, year = {2016}, doi = {10.1002/ana.24719}, pmid = {27398953}, url = {https://doi.org/10.1002/ana.24719} } @article{grande2019-31173841, author = {Grande, G. and Triolo, F. and Nuara, A. and Welmer, A. K. and Fratiglioni, L. and Vetrano, D. L.}, title = {{Measuring gait speed to better identify prodromal dementia}}, journal = {Experimental gerontology}, year = {2019}, doi = {10.1016/j.exger.2019.05.014}, pmid = {31173841}, url = {https://doi.org/10.1016/j.exger.2019.05.014} } @article{janelidze2016-27241045, author = {Janelidze, S. and Stomrud, E. and Palmqvist, S. and Zetterberg, H. and van Westen, D. and Jeromin, A. and Song, L. and Hanlon, D. and others}, title = {{Plasma β-amyloid in Alzheimer's disease and vascular disease}}, journal = {Scientific reports}, year = {2016}, doi = {10.1038/srep26801}, pmid = {27241045}, url = {https://doi.org/10.1038/srep26801} } @article{ritchie2001-11148233, author = {Ritchie, K. and Artero, S. and Touchon, J.}, title = {{Classification criteria for mild cognitive impairment: a population-based validation study}}, journal = {Neurology}, year = {2001}, doi = {10.1212/wnl.56.1.37}, pmid = {11148233}, url = {https://doi.org/10.1212/wnl.56.1.37} } @article{slot2019-30555032, author = {Slot, R. E. R. and Sikkes, S. A. M. and Berkhof, J. and Brodaty, H. and Buckley, R. and Cavedo, E. and Dardiotis, E. and Guillo-Benarous, F. and others}, title = {{Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2019}, doi = {10.1016/j.jalz.2018.10.003}, pmid = {30555032}, url = {https://doi.org/10.1016/j.jalz.2018.10.003} } @article{farias2009-19752306, author = {Farias, S. T. and Mungas, D. and Reed, B. R. and Harvey, D. and DeCarli, C.}, title = {{Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts}}, journal = {Archives of neurology}, year = {2009}, doi = {10.1001/archneurol.2009.106}, pmid = {19752306}, url = {https://doi.org/10.1001/archneurol.2009.106} } @article{verberk2018-30196548, author = {Verberk, I. M. W. and Slot, R. E. and Verfaillie, S. C. J. and Heijst, H. and Prins, N. D. and van Berckel, B. N. M. and Scheltens, P. and Teunissen, C. E. and others}, title = {{Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes}}, journal = {Annals of neurology}, year = {2018}, doi = {10.1002/ana.25334}, pmid = {30196548}, url = {https://doi.org/10.1002/ana.25334} } @article{pedersen2013-23529397, author = {Pedersen, K. F. and Larsen, J. P. and Tysnes, O. B. and Alves, G.}, title = {{Prognosis of mild cognitive impairment in early Parkinson disease: the Norwegian ParkWest study}}, journal = {JAMA neurology}, year = {2013}, doi = {10.1001/jamaneurol.2013.2110}, pmid = {23529397}, url = {https://doi.org/10.1001/jamaneurol.2013.2110} } @article{mossello2015-25730775, author = {Mossello, E. and Pieraccioli, M. and Nesti, N. and Bulgaresi, M. and Lorenzi, C. and Caleri, V. and Tonon, E. and Cavallini, M. C. and others}, title = {{Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs}}, journal = {JAMA internal medicine}, year = {2015}, doi = {10.1001/jamainternmed.2014.8164}, pmid = {25730775}, url = {https://doi.org/10.1001/jamainternmed.2014.8164} } @article{ou2019-31253185, author = {Ou, Y. N. and Xu, W. and Li, J. Q. and Guo, Y. and Cui, M. and Chen, K. L. and Huang, Y. Y. and Dong, Q. and others}, title = {{FDG-PET as an independent biomarker for Alzheimer's biological diagnosis: a longitudinal study}}, journal = {Alzheimer's research \& therapy}, year = {2019}, doi = {10.1186/s13195-019-0512-1}, pmid = {31253185}, url = {https://doi.org/10.1186/s13195-019-0512-1} } @article{irazoki2020-32373018, author = {Irazoki, E. and Contreras-Somoza, L. M. and Toribio-Guzmán, J. M. and Jenaro-Río, C. and van der Roest, H. and Franco-Martín, M. A.}, title = {{Technologies for Cognitive Training and Cognitive Rehabilitation for People With Mild Cognitive Impairment and Dementia. A Systematic Review}}, journal = {Frontiers in psychology}, year = {2020}, doi = {10.3389/fpsyg.2020.00648}, pmid = {32373018}, url = {https://doi.org/10.3389/fpsyg.2020.00648} } @article{thambisetty2012-21824521, author = {Thambisetty, M. and An, Y. and Kinsey, A. and Koka, D. and Saleem, M. and Güntert, A. and Kraut, M. and Ferrucci, L. and others}, title = {{Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment}}, journal = {NeuroImage}, year = {2012}, doi = {10.1016/j.neuroimage.2011.07.056}, pmid = {21824521}, url = {https://doi.org/10.1016/j.neuroimage.2011.07.056} } @article{greenberg2022-36216518, author = {Greenberg, B. D. and Pettigrew, C. and Soldan, A. and Wang, J. and Wang, M. C. and Darrow, J. A. and Albert, M. S. and Moghekar, A.}, title = {{CSF Alzheimer Disease Biomarkers: Time-Varying Relationships With MCI Symptom Onset and Associations With Age, Sex, and ApoE4}}, journal = {Neurology}, year = {2022}, doi = {10.1212/wnl.0000000000200953}, pmid = {36216518}, url = {https://doi.org/10.1212/wnl.0000000000200953} } @article{pusil2019-31633176, author = {Pusil, S. and López, M. E. and Cuesta, P. and Bruña, R. and Pereda, E. and Maestú, F.}, title = {{Hypersynchronization in mild cognitive impairment: the 'X' model}}, journal = {Brain : a journal of neurology}, year = {2019}, doi = {10.1093/brain/awz320}, pmid = {31633176}, url = {https://doi.org/10.1093/brain/awz320} } @article{belleville2008-17958927, author = {Belleville, S.}, title = {{Cognitive training for persons with mild cognitive impairment}}, journal = {International psychogeriatrics}, year = {2008}, doi = {10.1017/s104161020700631x}, pmid = {17958927}, url = {https://doi.org/10.1017/s104161020700631x} } @article{delbaere2012-23011051, author = {Delbaere, K. and Kochan, N. A. and Close, J. C. and Menant, J. C. and Sturnieks, D. L. and Brodaty, H. and Sachdev, P. S. and Lord, SR.}, title = {{Mild cognitive impairment as a predictor of falls in community-dwelling older people}}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, year = {2012}, doi = {10.1097/jgp.0b013e31824afbc4}, pmid = {23011051}, url = {https://doi.org/10.1097/jgp.0b013e31824afbc4} } @article{milaaloma2022-35953717, author = {Milà-Alomà, M. and Ashton, N. J. and Shekari, M. and Salvadó, G. and Ortiz-Romero, P. and Montoliu-Gaya, L. and Benedet, A. L. and Karikari, T. K. and others}, title = {{Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease}}, journal = {Nature medicine}, year = {2022}, doi = {10.1038/s41591-022-01925-w}, pmid = {35953717}, url = {https://doi.org/10.1038/s41591-022-01925-w} } @article{boyle2010-20194831, author = {Boyle, P. A. and Buchman, A. S. and Barnes, L. L. and Bennett, D. A.}, title = {{Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons}}, journal = {Archives of general psychiatry}, year = {2010}, doi = {10.1001/archgenpsychiatry.2009.208}, pmid = {20194831}, url = {https://doi.org/10.1001/archgenpsychiatry.2009.208} } @article{cottez2026-42273887, author = {Cottez, Rosalie J and Peyrot, Clémence and Denis, Hélèna L and Tremblay, Cyntia and Loiselle, Andréanne and Dallaire-Théroux, Caroline and Filali-Mouhim, Ali and Hébert, Sébastien S and others}, title = {{Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71588}, pmid = {42273887}, url = {https://doi.org/10.1002/alz.71588} } @article{paoletti2023-37095141, author = {Paoletti, Federico Paolini and Gaetani, Lorenzo and Bellomo, Giovanni and Chipi, Elena and Salvadori, Nicola and Montanucci, Chiara and Mancini, Andrea and Filidei, Marta and others}, title = {{CSF neurochemical profile and cognitive changes in Parkinson's disease with mild cognitive impairment}}, journal = {NPJ Parkinson's disease}, year = {2023}, doi = {10.1038/s41531-023-00509-w}, pmid = {37095141}, url = {https://doi.org/10.1038/s41531-023-00509-w} } @article{vintimilla2020-33442392, author = {Vintimilla, Raul and Balasubramanian, Kishore and Hall, James and Johnson, Leigh and O'Bryant, Sid}, title = {{Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment}}, journal = {Dementia and geriatric cognitive disorders extra}, year = {2020}, doi = {10.1159/000511103}, pmid = {33442392}, url = {https://doi.org/10.1159/000511103} } @article{pettigrew2017-27544202, author = {Pettigrew, Corinne and Soldan, Anja and Zhu, Yuxin and Wang, Mei-Cheng and Brown, Timothy and Miller, Michael and Albert, Marilyn and {BIOCARD Research Team}}, title = {{Cognitive reserve and cortical thickness in preclinical Alzheimer's disease}}, journal = {Brain imaging and behavior}, year = {2017}, doi = {10.1007/s11682-016-9581-y}, pmid = {27544202}, url = {https://doi.org/10.1007/s11682-016-9581-y} } @article{zhang2022-35526259, author = {Zhang, Ye and Tatewaki, Yasuko and Liu, Yingxu and Tomita, Naoki and Nagasaka, Tatsuo and Muranaka, Michiho and Yamamoto, Shuzo and Takano, Yumi and others}, title = {{Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer's disease}}, journal = {GeroScience}, year = {2022}, doi = {10.1007/s11357-022-00584-6}, pmid = {35526259}, url = {https://doi.org/10.1007/s11357-022-00584-6} } @article{gu2024-38183363, author = {Gu, Y. and Honig, L. S. and Kang, M. S. and Bahl, A. and Sanchez, D. and Reyes-Dumeyer, D. and Manly, J. J. and Dage, J. L. and others}, title = {{Risk of Alzheimer's disease is associated with longitudinal changes in plasma biomarkers in the multi-ethnic Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP) cohort}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13652}, pmid = {38183363}, url = {https://doi.org/10.1002/alz.13652} } @article{tang2014-24817210, author = {Tang, W. and Huang, Q. and Yao, Y. Y. and Wang, Y. and Wu, Y. L. and Wang, Z. Y.}, title = {{Does CSF p-tau181 help to discriminate Alzheimer's disease from other dementias and mild cognitive impairment? A meta-analysis of the literature}}, journal = {Journal of neural transmission (Vienna, Austria : 1996)}, year = {2014}, doi = {10.1007/s00702-014-1226-y}, pmid = {24817210}, url = {https://doi.org/10.1007/s00702-014-1226-y} } @article{martinezdubarbie2024-39559871, author = {Martínez-Dubarbie, F. and Guerra-Ruiz, A. and López-García, S. and Lage, C. and Fernández-Matarrubia, M. and Infante, J. and Pozueta-Cantudo, A. and García-Martínez, M. and others}, title = {{Diagnostic Accuracy of Plasma p-tau217 for Detecting Pathological Cerebrospinal Fluid Changes in Cognitively Unimpaired Subjects Using the Lumipulse Platform}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.152}, pmid = {39559871}, url = {https://doi.org/10.14283/jpad.2024.152} } @article{atri2026-42128444, author = {Atri, A. and Apostolova, L. G. and Iwata, A. and Wessels, A. M. and Atkins, A. and Lu, M. and Ye, W. and Ryan, S. and Doty, E. G.}, title = {{Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial}}, journal = {Neurology: Clinical Practice}, year = {2026}, doi = {10.1212/CPJ.0000000000200621}, pmid = {42128444}, url = {https://doi.org/10.1212/CPJ.0000000000200621} } @article{langbaum2025-41319675, author = {Langbaum, J. B. and Bradbury, A. R. and Egleston, B. L. and McCarty Wood, E. and Langlois, C. M. and Largent, E. A. and Harkins, K. and Erickson, C. M. and Stites, S. D. and Oyen, E. and others}, title = {{Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1}}, journal = {The Lancet Healthy Longevity}, year = {2025}, doi = {10.1016/j.lanhl.2025.100778}, pmid = {41319675}, url = {https://doi.org/10.1016/j.lanhl.2025.100778} } @article{sprecher2017-28679595, author = {Sprecher, K. E. and Koscik, R. L. and Carlsson, C. M. and Zetterberg, H. and Blennow, K. and Okonkwo, O. C. and Sager, M. A. and Asthana, S. and others}, title = {{Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004171}, pmid = {28679595}, url = {https://doi.org/10.1212/wnl.0000000000004171} } @article{young2022-35435938, author = {Young, C. B. and Winer, JR. and Younes, K. and Cody, K. A. and Betthauser, T. J. and Johnson, S. C. and Schultz, A. and Sperling, R. A. and others}, title = {{Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease}}, journal = {JAMA neurology}, year = {2022}, doi = {10.1001/jamaneurol.2022.0676}, pmid = {35435938}, url = {https://doi.org/10.1001/jamaneurol.2022.0676} } @article{vanderveere2024-38986053, author = {van der Veere, P. J. and Hoogland, J. and Visser, L. N. C. and Van Harten, A. C. and Rhodius-Meester, H. F. and Sikkes, S. A. M. and Venkatraghavan, V. and Barkhof, F. and others}, title = {{Predicting Cognitive Decline in Amyloid-Positive Patients With Mild Cognitive Impairment or Mild Dementia}}, journal = {Neurology}, year = {2024}, doi = {10.1212/wnl.0000000000209605}, pmid = {38986053}, url = {https://doi.org/10.1212/wnl.0000000000209605} } @article{honig2024-38377442, author = {Hönig, M. and Altomare, D. and Caprioglio, C. and Collij, L. and Barkhof, F. and Van Berckel, B. and Scheltens, P. and Farrar, G. and others}, title = {{Association Between Years of Education and Amyloid Burden in Patients With Subjective Cognitive Decline, MCI, and Alzheimer Disease}}, journal = {Neurology}, year = {2024}, doi = {10.1212/wnl.0000000000208053}, pmid = {38377442}, url = {https://doi.org/10.1212/wnl.0000000000208053} } @article{villemagne2011-21280088, author = {Villemagne, V. L. and Pike, K. E. and Chételat, G. and Ellis, K. A. and Mulligan, R. S. and Bourgeat, P. and Ackermann, U. and Jones, G. and others}, title = {{Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease}}, journal = {Annals of neurology}, year = {2011}, doi = {10.1002/ana.22248}, pmid = {21280088}, url = {https://doi.org/10.1002/ana.22248} } @article{realdon2016-27887597, author = {Realdon, O. and Rossetto, F. and Nalin, M. and Baroni, I. and Cabinio, M. and Fioravanti, R. and Saibene, F. L. and Alberoni, M. and others}, title = {{Technology-enhanced multi-domain at home continuum of care program with respect to usual care for people with cognitive impairment: the Ability-TelerehABILITation study protocol for a randomized controlled trial}}, journal = {BMC psychiatry}, year = {2016}, doi = {10.1186/s12888-016-1132-y}, pmid = {27887597}, url = {https://doi.org/10.1186/s12888-016-1132-y} } @article{pike2022-34748154, author = {Pike, K. E. and Cavuoto, M. G. and Li, L. and Wright, B. J. and Kinsella, G. J.}, title = {{Subjective Cognitive Decline: Level of Risk for Future Dementia and Mild Cognitive Impairment, a Meta-Analysis of Longitudinal Studies}}, journal = {Neuropsychology review}, year = {2022}, doi = {10.1007/s11065-021-09522-3}, pmid = {34748154}, url = {https://doi.org/10.1007/s11065-021-09522-3} } @article{boespflug2018-28221821, author = {Boespflug, E. L. and Eliassen, J. C. and Dudley, J. A. and Shidler, M. D. and Kalt, W. and Summer, S. S. and Stein, A. L. and Stover, A. N. and others}, title = {{Enhanced neural activation with blueberry supplementation in mild cognitive impairment}}, journal = {Nutritional neuroscience}, year = {2018}, doi = {10.1080/1028415x.2017.1287833}, pmid = {28221821}, url = {https://doi.org/10.1080/1028415x.2017.1287833} } @article{petersen2010-20820000, author = {Petersen, R. C. and Roberts, R. O. and Knopman, D. S. and Geda, Y. E. and Cha, R. H. and Pankratz, V. S. and Boeve, B. F. and Tangalos, E. G. and others}, title = {{Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging}}, journal = {Neurology}, year = {2010}, doi = {10.1212/wnl.0b013e3181f11d85}, pmid = {20820000}, url = {https://doi.org/10.1212/wnl.0b013e3181f11d85} } @article{iranzo2014-24587002, author = {Iranzo, A. and Fernández-Arcos, A. and Tolosa, E. and Serradell, M. and Molinuevo, J. L. and Valldeoriola, F. and Gelpi, E. and Vilaseca, I. and others}, title = {{Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients}}, journal = {PloS one}, year = {2014}, doi = {10.1371/journal.pone.0089741}, pmid = {24587002}, url = {https://doi.org/10.1371/journal.pone.0089741} } @article{vos2015-25693589, author = {Vos, S. J. and Verhey, F. and Frölich, L. and Kornhuber, J. and Wiltfang, J. and Maier, W. and Peters, O. and Rüther, E. and others}, title = {{Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage}}, journal = {Brain : a journal of neurology}, year = {2015}, doi = {10.1093/brain/awv029}, pmid = {25693589}, url = {https://doi.org/10.1093/brain/awv029} } @article{silbert2012-22843262, author = {Silbert, L. C. and Dodge, H. H. and Perkins, L. G. and Sherbakov, L. and Lahna, D. and Erten-Lyons, D. and Woltjer, R. and Shinto, L. and others}, title = {{Trajectory of white matter hyperintensity burden preceding mild cognitive impairment}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e3182661f2b}, pmid = {22843262}, url = {https://doi.org/10.1212/wnl.0b013e3182661f2b} } @article{clare2003-14583963, author = {Clare, L. and Woods, R. T. and Moniz Cook, E. D. and Orrell, M. and Spector, A.}, title = {{Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia}}, journal = {The Cochrane database of systematic reviews}, year = {2003}, doi = {10.1002/14651858.cd003260}, pmid = {14583963}, url = {https://doi.org/10.1002/14651858.cd003260} } @article{johnson2013-23375563, author = {Johnson, K. A. and Sperling, R. A. and Gidicsin, C. M. and Carmasin, J. S. and Maye, J. E. and Coleman, R. E. and Reiman, E. M. and Sabbagh, M. N. and others}, title = {{Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2013}, doi = {10.1016/j.jalz.2012.10.007}, pmid = {23375563}, url = {https://doi.org/10.1016/j.jalz.2012.10.007} } @article{rawlings2019-31221696, author = {Rawlings, A. M. and Sharrett, A. R. and Albert, M. S. and Coresh, J. and Windham, B. G. and Power, M. C. and Knopman, D. S. and Walker, K. and others}, title = {{The Association of Late-Life Diabetes Status and Hyperglycemia With Incident Mild Cognitive Impairment and Dementia: The ARIC Study}}, journal = {Diabetes care}, year = {2019}, doi = {10.2337/dc19-0120}, pmid = {31221696}, url = {https://doi.org/10.2337/dc19-0120} } @article{ganguli2004-15249620, author = {Ganguli, M. and Dodge, H. H. and Shen, C. and DeKosky, S. T.}, title = {{Mild cognitive impairment, amnestic type: an epidemiologic study}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000132523.27540.81}, pmid = {15249620}, url = {https://doi.org/10.1212/01.wnl.0000132523.27540.81} } @article{larrieu2002-12451203, author = {Larrieu, S. and Letenneur, L. and Orgogozo, J. M. and Fabrigoule, C. and Amieva, H. and Le Carret, N. and Barberger-Gateau, P. and Dartigues, J. F.}, title = {{Incidence and outcome of mild cognitive impairment in a population-based prospective cohort}}, journal = {Neurology}, year = {2002}, doi = {10.1212/01.wnl.0000034176.07159.f8}, pmid = {12451203}, url = {https://doi.org/10.1212/01.wnl.0000034176.07159.f8} } @article{modrego2004-15313849, author = {Modrego, P. J. and Ferrández, J.}, title = {{Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study}}, journal = {Archives of neurology}, year = {2004}, doi = {10.1001/archneur.61.8.1290}, pmid = {15313849}, url = {https://doi.org/10.1001/archneur.61.8.1290} } @article{dilorito2022-35588315, author = {Di Lorito, C. and Bosco, A. and Rai, H. and Craven, M. and McNally, D. and Todd, C. and Booth, V. and Cowley, A. and others}, title = {{A systematic literature review and meta-analysis on digital health interventions for people living with dementia and Mild Cognitive Impairment}}, journal = {International journal of geriatric psychiatry}, year = {2022}, doi = {10.1002/gps.5730}, pmid = {35588315}, url = {https://doi.org/10.1002/gps.5730} } @article{blanco2023-37838690, author = {Blanco, K. and Salcidua, S. and Orellana, P. and Sauma-Pérez, T. and León, T. and Steinmetz, L. C. L. and Ibañez, A. and Duran-Aniotz, C. and others}, title = {{Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer's disease}}, journal = {Alzheimer's research \& therapy}, year = {2023}, doi = {10.1186/s13195-023-01304-8}, pmid = {37838690}, url = {https://doi.org/10.1186/s13195-023-01304-8} } @article{jack2010-20935035, author = {Jack, C. R. and Wiste, H. J. and Vemuri, P. and Weigand, S. D. and Senjem, M. L. and Zeng, G. and Bernstein, M. A. and Gunter, J. L. and others}, title = {{Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease}}, journal = {Brain : a journal of neurology}, year = {2010}, doi = {10.1093/brain/awq277}, pmid = {20935035}, url = {https://doi.org/10.1093/brain/awq277} } @article{drzezga2003-12764551, author = {Drzezga, A. and Lautenschlager, N. and Siebner, H. and Riemenschneider, M. and Willoch, F. and Minoshima, S. and Schwaiger, M. and Kurz, A.}, title = {{Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study}}, journal = {European journal of nuclear medicine and molecular imaging}, year = {2003}, doi = {10.1007/s00259-003-1194-1}, pmid = {12764551}, url = {https://doi.org/10.1007/s00259-003-1194-1} } @article{chetelat2005-15979341, author = {Chételat, G. and Landeau, B. and Eustache, F. and Mézenge, F. and Viader, F. and de la Sayette, V. and Desgranges, B. and Baron, J. C.}, title = {{Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study}}, journal = {NeuroImage}, year = {2005}, doi = {10.1016/j.neuroimage.2005.05.015}, pmid = {15979341}, url = {https://doi.org/10.1016/j.neuroimage.2005.05.015} } @article{sparksstein2012-22546352, author = {Sparks Stein, P. and Steffen, M. J. and Smith, C. and Jicha, G. and Ebersole, J. L. and Abner, E. and Dawson, D.}, title = {{Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2012}, doi = {10.1016/j.jalz.2011.04.006}, pmid = {22546352}, url = {https://doi.org/10.1016/j.jalz.2011.04.006} } @article{huijbers2015-25678559, author = {Huijbers, W. and Mormino, E. C. and Schultz, A. P. and Wigman, S. and Ward, A. M. and Larvie, M. and Amariglio, R. E. and Marshall, G. A. and others}, title = {{Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression}}, journal = {Brain : a journal of neurology}, year = {2015}, doi = {10.1093/brain/awv007}, pmid = {25678559}, url = {https://doi.org/10.1093/brain/awv007} } @article{lee2013-22932777, author = {Lee, L. K. and Shahar, S. and Chin, A. V. and Yusoff, N. A.}, title = {{Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial}}, journal = {Psychopharmacology}, year = {2013}, doi = {10.1007/s00213-012-2848-0}, pmid = {22932777}, url = {https://doi.org/10.1007/s00213-012-2848-0} } @article{leow2009-19280686, author = {Leow, A. D. and Yanovsky, I. and Parikshak, N. and Hua, X. and Lee, S. and Toga, A. W. and Jack, C. R. and Bernstein, M. A. and others}, title = {{Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition}}, journal = {NeuroImage}, year = {2009}, doi = {10.1016/j.neuroimage.2009.01.004}, pmid = {19280686}, url = {https://doi.org/10.1016/j.neuroimage.2009.01.004} } @article{decarli2007-17210817, author = {DeCarli, C. and Frisoni, G. B. and Clark, C. M. and Harvey, D. and Grundman, M. and Petersen, R. C. and Thal, L. J. and others}, title = {{Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia}}, journal = {Archives of neurology}, year = {2007}, doi = {10.1001/archneur.64.1.108}, pmid = {17210817}, url = {https://doi.org/10.1001/archneur.64.1.108} } @article{bubu2019-30794315, author = {Bubu, O. M. and Pirraglia, E. and Andrade, A. G. and Sharma, R. A. and Gimenez-Badia, S. and Umasabor-Bubu, O. Q. and Hogan, M. M. and Shim, A. M. and others}, title = {{Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes}}, journal = {Sleep}, year = {2019}, doi = {10.1093/sleep/zsz048}, pmid = {30794315}, url = {https://doi.org/10.1093/sleep/zsz048} } @article{ravaglia2008-18028343, author = {Ravaglia, G. and Forti, P. and Montesi, F. and Lucicesare, A. and Pisacane, N. and Rietti, E. and Dalmonte, E. and Bianchin, M. and others}, title = {{Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population}}, journal = {Journal of the American Geriatrics Society}, year = {2008}, doi = {10.1111/j.1532-5415.2007.01503.x}, pmid = {18028343}, url = {https://doi.org/10.1111/j.1532-5415.2007.01503.x} } @article{jack2008-17452062, author = {Jack, C. R. and Petersen, R. C. and Grundman, M. and Jin, S. and Gamst, A. and Ward, C. P. and Sencakova, D. and Doody, R. S. and others}, title = {{Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI}}, journal = {Neurobiology of aging}, year = {2008}, doi = {10.1016/j.neurobiolaging.2007.03.004}, pmid = {17452062}, url = {https://doi.org/10.1016/j.neurobiolaging.2007.03.004} } @article{liu2018-30171911, author = {Liu, D. and Cao, B. and Zhao, Y. and Huang, H. and McIntyre, R. S. and Rosenblat, J. D. and Zhou, H.}, title = {{Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis}}, journal = {Neuroscience letters}, year = {2018}, doi = {10.1016/j.neulet.2018.08.038}, pmid = {30171911}, url = {https://doi.org/10.1016/j.neulet.2018.08.038} } @article{vanrossum2010-20413876, author = {van Rossum, I. A. and Vos, S. and Handels, R. and Visser, P. J.}, title = {{Biomarkers as predictors for conversion from mild cognitive impairment to Alzheimer-type dementia: implications for trial design}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2010}, doi = {10.3233/jad-2010-091606}, pmid = {20413876}, url = {https://doi.org/10.3233/jad-2010-091606} } @article{uchida2024-39476236, author = {Uchida, Y. and Nishimaki, K. and Soldan, A. and Moghekar, A. and Albert, M. and Oishi, K.}, title = {{Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment}}, journal = {JAMA network open}, year = {2024}, doi = {10.1001/jamanetworkopen.2024.41505}, pmid = {39476236}, url = {https://doi.org/10.1001/jamanetworkopen.2024.41505} } @article{breton2019-30370616, author = {Breton, A. and Casey, D. and Arnaoutoglou, N. A.}, title = {{Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: Meta-analysis of diagnostic accuracy studies}}, journal = {International journal of geriatric psychiatry}, year = {2019}, doi = {10.1002/gps.5016}, pmid = {30370616}, url = {https://doi.org/10.1002/gps.5016} } @article{dickerson2007-18056553, author = {Dickerson, B. C. and Sperling, R. A. and Hyman, B. T. and Albert, M. S. and Blacker, D.}, title = {{Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment}}, journal = {Archives of general psychiatry}, year = {2007}, doi = {10.1001/archpsyc.64.12.1443}, pmid = {18056553}, url = {https://doi.org/10.1001/archpsyc.64.12.1443} } @article{chen2022-35493941, author = {Chen, Y. and Qian, X. and Zhang, Y. and Su, W. and Huang, Y. and Wang, X. and Chen, X. and Zhao, E. and others}, title = {{Prediction Models for Conversion From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review and Meta-Analysis}}, journal = {Frontiers in aging neuroscience}, year = {2022}, doi = {10.3389/fnagi.2022.840386}, pmid = {35493941}, url = {https://doi.org/10.3389/fnagi.2022.840386} } @article{petersen2006-16682536, author = {Petersen, R. C. and Parisi, J. E. and Dickson, D. W. and Johnson, K. A. and Knopman, D. S. and Boeve, B. F. and Jicha, G. A. and Ivnik, R. J. and others}, title = {{Neuropathologic features of amnestic mild cognitive impairment}}, journal = {Archives of neurology}, year = {2006}, doi = {10.1001/archneur.63.5.665}, pmid = {16682536}, url = {https://doi.org/10.1001/archneur.63.5.665} } @article{yim2025-40829110, author = {Yim, Sohyun and Park, Seongbeom and Lim, Kyoungyoon and Kang, Heekyung and Shin, Daeun and Jo, Hyunjin and Jang, Hyemin and Weiner, Michael Walter and others}, title = {{Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213954}, pmid = {40829110}, url = {https://doi.org/10.1212/wnl.0000000000213954} } @article{kirsebom2025-40442871, author = {Kirsebom, Bjørn‐Eivind and González‐Ortiz, Fernando and Vigneswaran, Sinthujah and Bråthen, Geir and Skogseth, Ragnhild Eide and Gísladóttir, Berglind and Harrison, Peter and Jarholm, Jonas Alexander and others}, title = {{Repeated plasma p‐tau217 measurements to monitor clinical progression heterogeneity}}, journal = {Alzheimer s \& Dementia}, year = {2025}, doi = {10.1002/alz.70319}, pmid = {40442871}, url = {https://doi.org/10.1002/alz.70319} } @article{winblad2004-15324367, author = {Winblad, Bengt G. and Palmer, Katie and Kivipelto, Miia and Jelić, Vesna and Fratiglioni, Laura and Wahlund, Lars‐Olof and Nordberg, Agneta K. and Bäckman, Lars and others}, title = {{Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment}}, journal = {Journal of Internal Medicine}, year = {2004}, doi = {10.1111/j.1365-2796.2004.01380.x}, pmid = {15324367}, url = {https://doi.org/10.1111/j.1365-2796.2004.01380.x} } @article{mormino2016-27548655, author = {Mormino, E. C. and Papp, K. V. and Rentz, D. M. and Schultz, A. P. and LaPoint, M. and Amariglio, R. and Hanseeuw, B. and Marshall, G. A. and others}, title = {{Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals}}, journal = {JAMA neurology}, year = {2016}, doi = {10.1001/jamaneurol.2016.2237}, pmid = {27548655}, url = {https://doi.org/10.1001/jamaneurol.2016.2237} } @article{vargassoria2023-36869375, author = {Vargas-Soria, M. and García-Alloza, M. and Corraliza-Gómez, M.}, title = {{Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies}}, journal = {Journal of neuroinflammation}, year = {2023}, doi = {10.1186/s12974-023-02740-x}, pmid = {36869375}, url = {https://doi.org/10.1186/s12974-023-02740-x} } @article{moon2025-40544093, author = {Moon, Hasom and Chen, Xi and {Alzheimer’s Disease Neuroimaging Initiative}}, title = {{Plasma p-tau217 predicting brain-wide tau accumulation in preclinical AD}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2025.100252}, pmid = {40544093}, url = {https://doi.org/10.1016/j.tjpad.2025.100252} } @article{mazzeo2024-37723371, author = {Mazzeo, Salvatore and Ingannato, Assunta and Giacomucci, Giulia and Bagnoli, Silvia and Cavaliere, Arianna and Moschini, Valentina and Balestrini, Juri and Morinelli, Carmen and others}, title = {{The role of plasma neurofilament light chain and glial fibrillary acidic protein in subjective cognitive decline and mild cognitive impairment}}, journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology}, year = {2024}, doi = {10.1007/s10072-023-07065-4}, pmid = {37723371}, url = {https://doi.org/10.1007/s10072-023-07065-4} } @article{pettigrew2025-40151521, author = {Pettigrew, Corinne and Soldan, Anja and Wang, Jiangxia and Hohman, Timothy and Dumitrescu, Logan and Albert, Marilyn and Blennow, Kaj and Bittner, Tobias and others}, title = {{Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2025}, doi = {10.1002/dad2.70081}, pmid = {40151521}, url = {https://doi.org/10.1002/dad2.70081} } @article{vogelgsang2024-38940303, author = {Vogelgsang, Jonathan and Hansen, Niels and Stark, Melina and Wagner, Michael and Klafki, Hans and Morgado, Barbara Marcos and Jahn-Brodmann, Anke and Schott, Björn and others}, title = {{Plasma amyloid beta X-42/X-40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13909}, pmid = {38940303}, url = {https://doi.org/10.1002/alz.13909} } @article{guzmanvelez2024-39748841, author = {Guzmán-Vélez, Edmarie and Rivera-Hernández, Angelys and Fabrega, Sofia and Oliveira, Gabriel and Martínez, Jairo E and Baena, Ana and Picard, Glen and Lopera, Francisco and others}, title = {{Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal-dominant Alzheimer's disease}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2024}, doi = {10.1002/trc2.70003}, pmid = {39748841}, url = {https://doi.org/10.1002/trc2.70003} } @article{ossenkoppele2025-40670684, author = {Ossenkoppele, Rik and Coomans, Emma M and Apostolova, Liana G and Baker, Suzanne L and Barthel, Henryk and Beach, Thomas G and Benzinger, Tammy L S and Betthauser, Tobey and others}, title = {{Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex}}, journal = {Nature neuroscience}, year = {2025}, doi = {10.1038/s41593-025-02000-6}, pmid = {40670684}, url = {https://doi.org/10.1038/s41593-025-02000-6} } @article{wollenweber2016-27539301, author = {Wollenweber, Frank Arne and Därr, Sonja and Müller, Claudia and Duering, Marco and Buerger, Katharina and Zietemann, Vera and Malik, Rainer and Brendel, Matthias and others}, title = {{Prevalence of Amyloid Positron Emission Tomographic Positivity in Poststroke Mild Cognitive Impairment}}, journal = {Stroke}, year = {2016}, doi = {10.1161/strokeaha.116.013778}, pmid = {27539301}, url = {https://doi.org/10.1161/strokeaha.116.013778} } @article{kivisakk2022-35800899, author = {Kivisäkk, P. and Magdamo, C. and Trombetta, B. A. and Noori, A. and Kuo, Y. K. E. and Chibnik, L. B. and Carlyle, B. C. and Serrano-Pozo, A. and others}, title = {{Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment}}, journal = {Brain communications}, year = {2022}, doi = {10.1093/braincomms/fcac155}, pmid = {35800899}, url = {https://doi.org/10.1093/braincomms/fcac155} } @article{morris2010-20186853, author = {Morris, J. C. and Roe, C. M. and Xiong, C. and Fagan, A. M. and Goate, A. M. and Holtzman, D. M. and Mintun, M. A.}, title = {{APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging}}, journal = {Annals of neurology}, year = {2010}, doi = {10.1002/ana.21843}, pmid = {20186853}, url = {https://doi.org/10.1002/ana.21843} } @article{gurol2006-16401840, author = {Gurol, M. E. and Irizarry, M. C. and Smith, E. E. and Raju, S. and Diaz-Arrastia, R. and Bottiglieri, T. and Rosand, J. and Growdon, J. H. and others}, title = {{Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000191403.95453.6a}, pmid = {16401840}, url = {https://doi.org/10.1212/01.wnl.0000191403.95453.6a} } @article{yates2014-24623839, author = {Yates, P. A. and Desmond, P. M. and Phal, P. M. and Steward, C. and Szoeke, C. and Salvado, O. and Ellis, K. A. and Martins, R. N. and others}, title = {{Incidence of cerebral microbleeds in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000285}, pmid = {24623839}, url = {https://doi.org/10.1212/wnl.0000000000000285} } @article{lafaillemagnan2017-28659431, author = {Lafaille-Magnan, M. E. and Poirier, J. and Etienne, P. and Tremblay-Mercier, J. and Frenette, J. and Rosa-Neto, P. and Breitner, J. C. S. and {PREVENT-AD Research Group}}, title = {{Odor identification as a biomarker of preclinical AD in older adults at risk}}, journal = {Neurology}, year = {2017}, doi = {10.1212/wnl.0000000000004159}, pmid = {28659431}, url = {https://doi.org/10.1212/wnl.0000000000004159} } @article{krellroesch2017-28135351, author = {Krell-Roesch, J. and Vemuri, P. and Pink, A. and Roberts, R. O. and Stokin, G. B. and Mielke, M. M. and Christianson, T. J. and Knopman, D. S. and others}, title = {{Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2016.3822}, pmid = {28135351}, url = {https://doi.org/10.1001/jamaneurol.2016.3822} } @article{raschetti2007-18044984, author = {Raschetti, R. and Albanese, E. and Vanacore, N. and Maggini, M.}, title = {{Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials}}, journal = {PLoS medicine}, year = {2007}, doi = {10.1371/journal.pmed.0040338}, pmid = {18044984}, url = {https://doi.org/10.1371/journal.pmed.0040338} } @article{reitz2007-18071036, author = {Reitz, C. and Tang, M. X. and Manly, J. and Mayeux, R. and Luchsinger, J. A.}, title = {{Hypertension and the risk of mild cognitive impairment}}, journal = {Archives of neurology}, year = {2007}, doi = {10.1001/archneur.64.12.1734}, pmid = {18071036}, url = {https://doi.org/10.1001/archneur.64.12.1734} } @article{manly2008-18300306, author = {Manly, J. J. and Tang, M. X. and Schupf, N. and Stern, Y. and Vonsattel, J. P. and Mayeux, R.}, title = {{Frequency and course of mild cognitive impairment in a multiethnic community}}, journal = {Annals of neurology}, year = {2008}, doi = {10.1002/ana.21326}, pmid = {18300306}, url = {https://doi.org/10.1002/ana.21326} } @article{goetzl2015-26062630, author = {Goetzl, E. J. and Boxer, A. and Schwartz, J. B. and Abner, E. L. and Petersen, R. C. and Miller, B. L. and Kapogiannis, D.}, title = {{Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001702}, pmid = {26062630}, url = {https://doi.org/10.1212/wnl.0000000000001702} } @article{roberts2014-24353333, author = {Roberts, R. O. and Knopman, D. S. and Mielke, M. M. and Cha, R. H. and Pankratz, V. S. and Christianson, T. J. and Geda, Y. E. and Boeve, B. F. and others}, title = {{Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal}}, journal = {Neurology}, year = {2014}, doi = {10.1212/wnl.0000000000000055}, pmid = {24353333}, url = {https://doi.org/10.1212/wnl.0000000000000055} } @article{koepsell2012-23019264, author = {Koepsell, T. D. and Monsell, S. E.}, title = {{Reversion from mild cognitive impairment to normal or near-normal cognition: risk factors and prognosis}}, journal = {Neurology}, year = {2012}, doi = {10.1212/wnl.0b013e31826e26b7}, pmid = {23019264}, url = {https://doi.org/10.1212/wnl.0b013e31826e26b7} } @article{mosconi2008-17222480, author = {Mosconi, L. and De Santi, S. and Li, J. and Tsui, W. H. and Li, Y. and Boppana, M. and Laska, E. and Rusinek, H. and others}, title = {{Hippocampal hypometabolism predicts cognitive decline from normal aging}}, journal = {Neurobiology of aging}, year = {2008}, doi = {10.1016/j.neurobiolaging.2006.12.008}, pmid = {17222480}, url = {https://doi.org/10.1016/j.neurobiolaging.2006.12.008} } @article{buckley2017-28973551, author = {Buckley, R. F. and Hanseeuw, B. and Schultz, A. P. and Vannini, P. and Aghjayan, S. L. and Properzi, M. J. and Jackson, J. D. and Mormino, E. C. and others}, title = {{Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden}}, journal = {JAMA neurology}, year = {2017}, doi = {10.1001/jamaneurol.2017.2216}, pmid = {28973551}, url = {https://doi.org/10.1001/jamaneurol.2017.2216} } @article{wang2020-32962744, author = {Wang, X. and Huang, W. and Su, L. and Xing, Y. and Jessen, F. and Sun, Y. and Shu, N. and Han, Y.}, title = {{Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease}}, journal = {Molecular neurodegeneration}, year = {2020}, doi = {10.1186/s13024-020-00395-3}, pmid = {32962744}, url = {https://doi.org/10.1186/s13024-020-00395-3} } @article{bidelman2017-28270574, author = {Bidelman, G. M. and Lowther, J. E. and Tak, S. H. and Alain, C.}, title = {{Mild Cognitive Impairment Is Characterized by Deficient Brainstem and Cortical Representations of Speech}}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, year = {2017}, doi = {10.1523/jneurosci.3700-16.2017}, pmid = {28270574}, url = {https://doi.org/10.1523/jneurosci.3700-16.2017} } @article{djabelkhir2017-29200836, author = {Djabelkhir, L. and Wu, Y. H. and Vidal, J. S. and Cristancho-Lacroix, V. and Marlats, F. and Lenoir, H. and Carno, A. and Rigaud, A. S.}, title = {{Computerized cognitive stimulation and engagement programs in older adults with mild cognitive impairment: comparing feasibility, acceptability, and cognitive and psychosocial effects}}, journal = {Clinical interventions in aging}, year = {2017}, doi = {10.2147/cia.s145769}, pmid = {29200836}, url = {https://doi.org/10.2147/cia.s145769} } @article{fiandaca2015-25130657, author = {Fiandaca, M. S. and Kapogiannis, D. and Mapstone, M. and Boxer, A. and Eitan, E. and Schwartz, J. B. and Abner, E. L. and Petersen, R. C. and others}, title = {{Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2015}, doi = {10.1016/j.jalz.2014.06.008}, pmid = {25130657}, url = {https://doi.org/10.1016/j.jalz.2014.06.008} } @article{sachdev2010-20637138, author = {Sachdev, P. S. and Brodaty, H. and Reppermund, S. and Kochan, N. A. and Trollor, J. N. and Draper, B. and Slavin, M. J. and Crawford, J. and others}, title = {{The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years}}, journal = {International psychogeriatrics}, year = {2010}, doi = {10.1017/s1041610210001067}, pmid = {20637138}, url = {https://doi.org/10.1017/s1041610210001067} } @article{davatzikos2009-19416949, author = {Davatzikos, C. and Xu, F. and An, Y. and Fan, Y. and Resnick, S. M.}, title = {{Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index}}, journal = {Brain : a journal of neurology}, year = {2009}, doi = {10.1093/brain/awp091}, pmid = {19416949}, url = {https://doi.org/10.1093/brain/awp091} } @article{spasov2019-30654174, author = {Spasov, S. and Passamonti, L. and Duggento, A. and Liò, P. and Toschi, N. and {Alzheimer's Disease Neuroimaging Initiative}}, title = {{A parameter-efficient deep learning approach to predict conversion from mild cognitive impairment to Alzheimer's disease}}, journal = {NeuroImage}, year = {2019}, doi = {10.1016/j.neuroimage.2019.01.031}, pmid = {30654174}, url = {https://doi.org/10.1016/j.neuroimage.2019.01.031} } @article{berron2021-33725124, author = {Berron, D. and Vogel, J. W. and Insel, P. S. and Pereira, J. B. and Xie, L. and Wisse, L. E. M. and Yushkevich, P. A. and Palmqvist, S. and others}, title = {{Early stages of tau pathology and its associations with functional connectivity, atrophy and memory}}, journal = {Brain : a journal of neurology}, year = {2021}, doi = {10.1093/brain/awab114}, pmid = {33725124}, url = {https://doi.org/10.1093/brain/awab114} } @article{peres2006-16894108, author = {Pérès, K. and Chrysostome, V. and Fabrigoule, C. and Orgogozo, J. M. and Dartigues, J. F. and Barberger-Gateau, P.}, title = {{Restriction in complex activities of daily living in MCI: impact on outcome}}, journal = {Neurology}, year = {2006}, doi = {10.1212/01.wnl.0000228228.70065.f1}, pmid = {16894108}, url = {https://doi.org/10.1212/01.wnl.0000228228.70065.f1} } @article{davis2018-29357799, author = {Davis, M. and O Connell, T. and Johnson, S. and Cline, S. and Merikle, E. and Martenyi, F. and Simpson, K.}, title = {{Estimating Alzheimer's Disease Progression Rates from Normal Cognition Through Mild Cognitive Impairment and Stages of Dementia}}, journal = {Current Alzheimer research}, year = {2018}, doi = {10.2174/1567205015666180119092427}, pmid = {29357799}, url = {https://doi.org/10.2174/1567205015666180119092427} } @article{meghdadi2021-33544703, author = {Meghdadi, A. H. and Stevanović Karić, M. and McConnell, M. and Rupp, G. and Richard, C. and Hamilton, J. and Salat, D. and Berka, C.}, title = {{Resting state EEG biomarkers of cognitive decline associated with Alzheimer's disease and mild cognitive impairment}}, journal = {PloS one}, year = {2021}, doi = {10.1371/journal.pone.0244180}, pmid = {33544703}, url = {https://doi.org/10.1371/journal.pone.0244180} } @article{matthews2008-18662209, author = {Matthews, F. E. and Stephan, B. C. and McKeith, I. G. and Bond, J. and Brayne, C. and {Medical Research Council Cognitive Function and Ageing Study}}, title = {{Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?}}, journal = {Journal of the American Geriatrics Society}, year = {2008}, doi = {10.1111/j.1532-5415.2008.01820.x}, pmid = {18662209}, url = {https://doi.org/10.1111/j.1532-5415.2008.01820.x} } @article{rozzini2007-17117398, author = {Rozzini, L. and Costardi, D. and Chilovi, B. V. and Franzoni, S. and Trabucchi, M. and Padovani, A.}, title = {{Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors}}, journal = {International journal of geriatric psychiatry}, year = {2007}, doi = {10.1002/gps.1681}, pmid = {17117398}, url = {https://doi.org/10.1002/gps.1681} } @article{eyler2019-31177210, author = {Eyler, L. T. and Elman, J. A. and Hatton, S. N. and Gough, S. and Mischel, A. K. and Hagler, D. J. and Franz, C. E. and Docherty, A. and others}, title = {{Resting State Abnormalities of the Default Mode Network in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2019}, doi = {10.3233/jad-180847}, pmid = {31177210}, url = {https://doi.org/10.3233/jad-180847} } @article{qin2017-27113997, author = {Qin, X. Y. and Cao, C. and Cawley, N. X. and Liu, T. T. and Yuan, J. and Loh, Y. P. and Cheng, Y.}, title = {{Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer's disease: a meta-analysis study (N=7277)}}, journal = {Molecular psychiatry}, year = {2017}, doi = {10.1038/mp.2016.62}, pmid = {27113997}, url = {https://doi.org/10.1038/mp.2016.62} } @article{pankratz2015-25788555, author = {Pankratz, V. S. and Roberts, R. O. and Mielke, M. M. and Knopman, D. S. and Jack, C. R. and Geda, Y. E. and Rocca, W. A. and Petersen, R. C.}, title = {{Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging}}, journal = {Neurology}, year = {2015}, doi = {10.1212/wnl.0000000000001437}, pmid = {25788555}, url = {https://doi.org/10.1212/wnl.0000000000001437} } @article{babulal2024-38776513, author = {Babulal, G. M. and Chen, L. and Murphy, S. A. and Carr, D. B. and Morris, J. C.}, title = {{Predicting Driving Cessation Among Cognitively Normal Older Drivers: The Role of Alzheimer Disease Biomarkers and Clinical Assessments}}, journal = {Neurology}, year = {2024}, doi = {10.1212/wnl.0000000000209426}, pmid = {38776513}, url = {https://doi.org/10.1212/wnl.0000000000209426} } @article{study2017-28045051, author = {{Train the Brain Consortium}}, title = {{Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study}}, journal = {Scientific reports}, year = {2017}, doi = {10.1038/srep39471}, pmid = {28045051}, url = {https://doi.org/10.1038/srep39471} } @article{rosenberg2011-20845402, author = {Rosenberg, P. B. and Mielke, M. M. and Appleby, B. and Oh, E. and Leoutsakos, J. M. and Lyketsos, C. G.}, title = {{Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction}}, journal = {International journal of geriatric psychiatry}, year = {2011}, doi = {10.1002/gps.2535}, pmid = {20845402}, url = {https://doi.org/10.1002/gps.2535} } @article{mormino2017-28253478, author = {Mormino, E. C. and Papp, K. V. and Rentz, D. M. and Donohue, M. C. and Amariglio, R. and Quiroz, Y. T. and Chhatwal, J. and Marshall, G. A. and others}, title = {{Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2017}, doi = {10.1016/j.jalz.2017.01.018}, pmid = {28253478}, url = {https://doi.org/10.1016/j.jalz.2017.01.018} } @article{reboussin2025-39819096, author = {Reboussin, David M. and Gaussoin, Sarah A. and Pajewski, Nicholas M. and Jaeger, Byron C. and Sachs, Bonnie C. and Rapp, Stephen R. and Supiano, Mark A. and Cleveland, Maryjo L. and others}, title = {{Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT}}, journal = {Neurology}, year = {2025}, doi = {10.1212/wnl.0000000000213334}, pmid = {39819096}, url = {https://doi.org/10.1212/wnl.0000000000213334} } @article{bennett2002-12136057, author = {Bennett, David Alan and Wilson, Robert Smith and Schneider, Julie A. and Evans, Denis A. and Beckett, Laurel A. and Aggarwal, Neelum T. and Barnes, Lisa Laverne and Fox, J. H. and others}, title = {{Natural history of mild cognitive impairment in older persons}}, journal = {Neurology}, year = {2002}, doi = {10.1212/wnl.59.2.198}, pmid = {12136057}, url = {https://doi.org/10.1212/wnl.59.2.198} } @article{jessen2020-31958406, author = {Jessen, Frank and Amariglio, Rebecca England and Buckley, Rachel F. and van der Flier, Wiesje M. and Han, Ying and Molinuevo, José Luís and Rabin, Laura A. and Rentz, Dorene M. and Rodríguez‐Gómez, Octavio and Saykin, Andrew J. and Sikkes, Sietske A.M. and Smart, Colette M. and Wolfsgruber, Steffen and Wagner, Michael}, title = {{The characterisation of subjective cognitive decline}}, journal = {The Lancet Neurology}, year = {2020}, doi = {10.1016/s1474-4422(19)30368-0}, pmid = {31958406}, url = {https://doi.org/10.1016/s1474-4422(19)30368-0} } @article{herrera2012-22525705, author = {Herrera, C. and Chambon, C. and Michel, B. F. and Paban, V. and Alescio-Lautier, B.}, title = {{Positive effects of computer-based cognitive training in adults with mild cognitive impairment}}, journal = {Neuropsychologia}, year = {2012}, doi = {10.1016/j.neuropsychologia.2012.04.012}, pmid = {22525705}, url = {https://doi.org/10.1016/j.neuropsychologia.2012.04.012} } @article{wadley2007-17661957, author = {Wadley, V. G. and Crowe, M. and Marsiske, M. and Cook, S. E. and Unverzagt, F. W. and Rosenberg, A. L. and Rexroth, D.}, title = {{Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study}}, journal = {Journal of the American Geriatrics Society}, year = {2007}, doi = {10.1111/j.1532-5415.2007.01245.x}, pmid = {17661957}, url = {https://doi.org/10.1111/j.1532-5415.2007.01245.x} } @article{maraki2023-36692092, author = {Maraki, M. I. and Yannakoulia, M. and Xiromerisiou, G. and Stefanis, L. and Charisis, S. and Giagkou, N. and Kosmidis, M. H. and Dardiotis, E. and others}, title = {{Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study}}, journal = {European journal of neurology}, year = {2023}, doi = {10.1111/ene.15698}, pmid = {36692092}, url = {https://doi.org/10.1111/ene.15698} } @article{reynolds2026-42879726, author = {Reynolds, E. L. and Elafros, M. A. and Muthukumar, L. and Shippey, E. and Budhu, J. A. and Terman, S. W. and Burke, J. F. and Callaghan, B. C.}, title = {{Predictors of Antiamyloid Medication Utilization and Adherence Among People With Alzheimer Disease and Mild Cognitive Impairment}}, journal = {Neurology}, year = {2026}, doi = {10.1212/wnl.0000000000218594}, pmid = {42879726}, url = {https://doi.org/10.1212/wnl.0000000000218594} } @article{simren2021-33491853, author = {Simrén, J. and Leuzy, A. and Karikari, T. K. and Hye, A. and Benedet, A. L. and Lantero-Rodriguez, J. and Mattsson-Carlgren, N. and Schöll, M. and others}, title = {{The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2021}, doi = {10.1002/alz.12283}, pmid = {33491853}, url = {https://doi.org/10.1002/alz.12283} } @article{gonzalezortiz2024-37975513, author = {Gonzalez-Ortiz, F. and Ferreira, P. C. L. and González-Escalante, A. and Montoliu-Gaya, L. and Ortiz-Romero, P. and Kac, P. R. and Turton, M. and Kvartsberg, H. and others}, title = {{A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13525}, pmid = {37975513}, url = {https://doi.org/10.1002/alz.13525} } @article{chatterjee2021-33431793, author = {Chatterjee, P. and Pedrini, S. and Stoops, E. and Goozee, K. and Villemagne, V. L. and Asih, P. R. and Verberk, I. M. W. and Dave, P. and others}, title = {{Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease}}, journal = {Translational psychiatry}, year = {2021}, doi = {10.1038/s41398-020-01137-1}, pmid = {33431793}, url = {https://doi.org/10.1038/s41398-020-01137-1} } @article{molinahenry2024-38629508, author = {Molina-Henry, D. P. and Raman, R. and Liu, A. and Langford, O. and Johnson, K. and Shum, L. K. and Glover, C. M. and Dhadda, S. and others}, title = {{Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13803}, pmid = {38629508}, url = {https://doi.org/10.1002/alz.13803} } @article{obryant2022-34057802, author = {O'Bryant, S. E. and Zhang, F. and Petersen, M. and Hall, JR. and Johnson, L. A. and Yaffe, K. and Mason, D. and Braskie, M. and others}, title = {{A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2022}, doi = {10.1002/alz.12382}, pmid = {34057802}, url = {https://doi.org/10.1002/alz.12382} } @article{thomas2022-35318733, author = {Thomas, A. J. and Hamilton, C. A. and Heslegrave, A. and Barker, S. and Durcan, R. and Lawley, S. and Barnett, N. and Lett, D. and others}, title = {{A Longitudinal Study of Plasma pTau181 in Mild Cognitive Impairment with Lewy Bodies and Alzheimer's Disease}}, journal = {Movement disorders : official journal of the Movement Disorder Society}, year = {2022}, doi = {10.1002/mds.28994}, pmid = {35318733}, url = {https://doi.org/10.1002/mds.28994} } @article{guzmanparra2020-32442136, author = {Guzman-Parra, J. and Barnestein-Fonseca, P. and Guerrero-Pertiñez, G. and Anderberg, P. and Jimenez-Fernandez, L. and Valero-Moreno, E. and Goodman-Casanova, J. M. and Cuesta-Vargas, A. and others}, title = {{Attitudes and Use of Information and Communication Technologies in Older Adults With Mild Cognitive Impairment or Early Stages of Dementia and Their Caregivers: Cross-Sectional Study}}, journal = {Journal of medical Internet research}, year = {2020}, doi = {10.2196/17253}, pmid = {32442136}, url = {https://doi.org/10.2196/17253} } @article{mueller2021-34095435, author = {Mueller, K. D. and Van Hulle, C. A. and Koscik, R. L. and Jonaitis, E. and Peters, C. C. and Betthauser, T. J. and Christian, B. and Chin, N. and others}, title = {{Amyloid beta associations with connected speech in cognitively unimpaired adults}}, journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)}, year = {2021}, doi = {10.1002/dad2.12203}, pmid = {34095435}, url = {https://doi.org/10.1002/dad2.12203} } @article{donovan2018-29325447, author = {Donovan, N. J. and Locascio, J. J. and Marshall, G. A. and Gatchel, J. and Hanseeuw, B. J. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and others}, title = {{Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults}}, journal = {The American journal of psychiatry}, year = {2018}, doi = {10.1176/appi.ajp.2017.17040442}, pmid = {29325447}, url = {https://doi.org/10.1176/appi.ajp.2017.17040442} } @article{gleason2018-29125485, author = {Gleason, C. E. and Norton, D. and Anderson, E. D. and Wahoske, M. and Washington, D. T. and Umucu, E. and Koscik, R. L. and Dowling, N. M. and others}, title = {{Cognitive Variability Predicts Incident Alzheimer's Disease and Mild Cognitive Impairment Comparable to a Cerebrospinal Fluid Biomarker}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2018}, doi = {10.3233/jad-170498}, pmid = {29125485}, url = {https://doi.org/10.3233/jad-170498} } @article{cicognola2021-d7e9adeb, author = {Cicognola, C. and Janelidze, S. and Hertze, J. and Zetterberg, H. and Blennow, K. and Mattsson-Carlgren, N. and Hansson, O.}, title = {{Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment}}, journal = {Alzheimer's Research \& Therapy}, year = {2021}, pmid = {33773595} } @article{nguyen2024-38484190, author = {Nguyen, H. V. and Mital, S. and Knopman, D. S. and Alexander, G. C.}, title = {{Cost-Effectiveness of Lecanemab for Individuals With Early-Stage Alzheimer Disease}}, journal = {Neurology}, year = {2024}, doi = {10.1212/WNL.0000000000209218}, pmid = {38484190}, url = {https://doi.org/10.1212/WNL.0000000000209218} } @article{caselli2004-15184602, author = {Caselli, R. J. and Reiman, E. M. and Osborne, D. and Hentz, J. G. and Baxter, L. C. and Hernandez, J. L. and Alexander, G. G.}, title = {{Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele}}, journal = {Neurology}, year = {2004}, doi = {10.1212/01.wnl.0000129533.26544.bf}, pmid = {15184602}, url = {https://doi.org/10.1212/01.wnl.0000129533.26544.bf} } @article{graurivera2020-31907066, author = {Grau-Rivera, O. and Operto, G. and Falcón, C. and Sánchez-Benavides, G. and Cacciaglia, R. and Brugulat-Serrat, A. and Gramunt, N. and Salvadó, G. and others}, title = {{Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults}}, journal = {Alzheimer's research \& therapy}, year = {2020}, doi = {10.1186/s13195-019-0547-3}, pmid = {31907066}, url = {https://doi.org/10.1186/s13195-019-0547-3} } @article{horie2016-26713821, author = {Horie, N. C. and Serrao, V. T. and Simon, S. S. and Gascon, M. R. and Dos Santos, A. X. and Zambone, M. A. and Del Bigio de Freitas, M. M. and Cunha-Neto, E. and others}, title = {{Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment}}, journal = {The Journal of clinical endocrinology and metabolism}, year = {2016}, doi = {10.1210/jc.2015-2315}, pmid = {26713821}, url = {https://doi.org/10.1210/jc.2015-2315} } @article{petersen2001-11735772, author = {Petersen, R. C. and Doody, R. and Kurz, A. and Mohs, R. C. and Morris, J. C. and Rabins, P. V. and Ritchie, K. and Rossor, M. and others}, title = {{Current concepts in mild cognitive impairment}}, journal = {Archives of neurology}, year = {2001}, doi = {10.1001/archneur.58.12.1985}, pmid = {11735772}, url = {https://doi.org/10.1001/archneur.58.12.1985} } @article{musiek2018-29379963, author = {Musiek, E. S. and Bhimasani, M. and Zangrilli, M. A. and Morris, J. C. and Holtzman, D. M. and Ju, Y. S.}, title = {{Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease}}, journal = {JAMA neurology}, year = {2018}, doi = {10.1001/jamaneurol.2017.4719}, pmid = {29379963}, url = {https://doi.org/10.1001/jamaneurol.2017.4719} }