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% Source: https://alzhub.org/research?category=drug_development&about=digital-tools
% 24 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{cummings2022-35516416,
  author  = {Cummings, J. and Lee, G. and Nahed, P. and Kambar, M. E. Z. N. and Zhong, K. and Fonseca, J. and Taghva, K.},
  title   = {{Alzheimer's disease drug development pipeline: 2022}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12295},
  pmid    = {35516416},
  url     = {https://doi.org/10.1002/trc2.12295}
}

@article{rodriguez2021-33589615,
  author  = {Rodriguez, S. and Hug, C. and Todorov, P. and Moret, N. and Boswell, S. A. and Evans, K. and Zhou, G. and Johnson, N. T. and others},
  title   = {{Machine learning identifies candidates for drug repurposing in Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-21330-0},
  pmid    = {33589615},
  url     = {https://doi.org/10.1038/s41467-021-21330-0}
}

@article{hung2021-34133918,
  author  = {Hung, C. and Tuck, E. and Stubbs, V. and van der Lee, S. J. and Aalfs, C. and van Spaendonk, R. and Scheltens, P. and Hardy, J. and others},
  title   = {{SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.109259},
  pmid    = {34133918},
  url     = {https://doi.org/10.1016/j.celrep.2021.109259}
}

@article{zhang2024-39405916,
  author  = {Zhang, Yinbing and Tang, Cheng and He, Yao and Zhang, Yingqian and Li, Qinxi and Zhang, Ting and Zhao, Bangcheng and Tong, Aiping and others},
  title   = {{Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and human brain organoid models}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2024},
  doi     = {10.1016/j.biopha.2024.117540},
  pmid    = {39405916},
  url     = {https://doi.org/10.1016/j.biopha.2024.117540}
}

@article{germano2024-39216535,
  author  = {Germano, Leticia Forny and Koehler, Jacqueline A and Baggio, Laurie L and Cui, Fiona and Wong, Chi Kin and Rittig, Nikolaj and Cao, Xiemin and Matthews, Dianne and others},
  title   = {{The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice}},
  journal = {Molecular metabolism},
  year    = {2024},
  doi     = {10.1016/j.molmet.2024.102019},
  pmid    = {39216535},
  url     = {https://doi.org/10.1016/j.molmet.2024.102019}
}

@article{gao2024-39577323,
  author  = {Gao, Qi-Chao and Liu, Ge-Liang and Wang, Qi and Zhang, Sheng-Xiao and Ji, Zhi-Lin and Wang, Zhao-Jun and Wu, Mei-Na and Yu, Qi and others},
  title   = {{A promising drug repurposing approach for Alzheimer's treatment: Givinostat improves cognitive behavior and pathological features in APP/PS1 mice}},
  journal = {Redox biology},
  year    = {2024},
  doi     = {10.1016/j.redox.2024.103420},
  pmid    = {39577323},
  url     = {https://doi.org/10.1016/j.redox.2024.103420}
}

@article{maskery2020-32959677,
  author  = {Maskery, M. and Goulding, E. M. and Gengler, S. and Melchiorsen, J. U. and Rosenkilde, M. M. and Hölscher, C.},
  title   = {{The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2020},
  doi     = {10.1177/1533317520953041},
  pmid    = {32959677},
  url     = {https://doi.org/10.1177/1533317520953041}
}

@article{levy2022-36160048,
  author  = {Levy, Simon A and Zuniga, Gabrielle and Gonzalez, Elias M and Butler, David and Temple, Sally and Frost, Bess},
  title   = {{TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy}},
  journal = {Cell reports methods},
  year    = {2022},
  doi     = {10.1016/j.crmeth.2022.100292},
  pmid    = {36160048},
  url     = {https://doi.org/10.1016/j.crmeth.2022.100292}
}

@article{urbina2021-34274565,
  author  = {Urbina, Fabio and Puhl, Ana C and Ekins, Sean},
  title   = {{Recent advances in drug repurposing using machine learning}},
  journal = {Current opinion in chemical biology},
  year    = {2021},
  doi     = {10.1016/j.cbpa.2021.06.001},
  pmid    = {34274565},
  url     = {https://doi.org/10.1016/j.cbpa.2021.06.001}
}

@article{mcclean2014-23973293,
  author  = {McClean, P. L. and Hölscher, C.},
  title   = {{Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease}},
  journal = {Neuropharmacology},
  year    = {2014},
  doi     = {10.1016/j.neuropharm.2013.08.005},
  pmid    = {23973293},
  url     = {https://doi.org/10.1016/j.neuropharm.2013.08.005}
}

@article{faivre2013-23601582,
  author  = {Faivre, E. and Hölscher, C.},
  title   = {{Neuroprotective effects of D-Ala(2)GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model}},
  journal = {Alzheimer's research \& therapy},
  year    = {2013},
  doi     = {10.1186/alzrt174},
  pmid    = {23601582},
  url     = {https://doi.org/10.1186/alzrt174}
}

@article{lin2023-37350918,
  author  = {Lin, K. H. and Hsieh, K. L. and Jiang, X. and Kim, Y.},
  title   = {{Integrating Comorbidity Knowledge for Alzheimer's Disease Drug Repurposing using Multi-task Graph Neural Network}},
  journal = {AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science},
  year    = {2023},
  doi     = {10.1101/2020.04.30.069690},
  pmid    = {37350918},
  url     = {https://doi.org/10.1101/2020.04.30.069690}
}

@article{sun2019-30816709,
  author  = {Sun, J. and Liu, S. and Ling, Z. and Wang, F. and Ling, Y. and Gong, T. and Fang, N. and Ye, S. and others},
  title   = {{Fructooligosaccharides Ameliorating Cognitive Deficits and Neurodegeneration in APP/PS1 Transgenic Mice through Modulating Gut Microbiota}},
  journal = {Journal of agricultural and food chemistry},
  year    = {2019},
  doi     = {10.1021/acs.jafc.8b07313},
  pmid    = {30816709},
  url     = {https://doi.org/10.1021/acs.jafc.8b07313}
}

@article{cai2018-29175324,
  author  = {Cai, H. Y. and Yang, J. T. and Wang, Z. J. and Zhang, J. and Yang, W. and Wu, M. N. and Qi, J. S.},
  title   = {{Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2018},
  doi     = {10.1016/j.bbrc.2017.11.114},
  pmid    = {29175324},
  url     = {https://doi.org/10.1016/j.bbrc.2017.11.114}
}

@article{chen2017-28382596,
  author  = {Chen, S. and Sun, J. and Zhao, G. and Guo, A. and Chen, Y. and Fu, R. and Deng, Y.},
  title   = {{Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice}},
  journal = {Neurochemical research},
  year    = {2017},
  doi     = {10.1007/s11064-017-2250-8},
  pmid    = {28382596},
  url     = {https://doi.org/10.1007/s11064-017-2250-8}
}

@article{denver2018-29604345,
  author  = {Denver, P. and English, A. and McClean, P. L.},
  title   = {{Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2018},
  doi     = {10.1016/j.bbi.2018.03.032},
  pmid    = {29604345},
  url     = {https://doi.org/10.1016/j.bbi.2018.03.032}
}

@article{cao2018-29551659,
  author  = {Cao, Y. and Hölscher, C. and Hu, M. M. and Wang, T. and Zhao, F. and Bai, Y. and Zhang, J. and Wu, M. N. and others},
  title   = {{DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease}},
  journal = {European journal of pharmacology},
  year    = {2018},
  doi     = {10.1016/j.ejphar.2018.03.024},
  pmid    = {29551659},
  url     = {https://doi.org/10.1016/j.ejphar.2018.03.024}
}

@article{zeng2019-31116390,
  author  = {Zeng, X. and Zhu, S. and Liu, X. and Zhou, Y. and Nussinov, R. and Cheng, F.},
  title   = {{deepDR: a network-based deep learning approach to in silico drug repositioning}},
  journal = {Bioinformatics (Oxford, England)},
  year    = {2019},
  doi     = {10.1093/bioinformatics/btz418},
  pmid    = {31116390},
  url     = {https://doi.org/10.1093/bioinformatics/btz418}
}

@article{ou2018-29253574,
  author  = {Ou, Z. and Kong, X. and Sun, X. and He, X. and Zhang, L. and Gong, Z. and Huang, J. and Xu, B. and others},
  title   = {{Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2018},
  doi     = {10.1016/j.bbi.2017.12.009},
  pmid    = {29253574},
  url     = {https://doi.org/10.1016/j.bbi.2017.12.009}
}

@article{poon2004-15262209,
  author  = {Poon, H. F. and Joshi, G. and Sultana, R. and Farr, S. A. and Banks, W. A. and Morley, J. E. and Calabrese, V. and Butterfield, D. A.},
  title   = {{Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice}},
  journal = {Brain research},
  year    = {2004},
  doi     = {10.1016/j.brainres.2004.05.048},
  pmid    = {15262209},
  url     = {https://doi.org/10.1016/j.brainres.2004.05.048}
}

@article{gengler2012-20359773,
  author  = {Gengler, S. and McClean, P. L. and McCurtin, R. and Gault, V. A. and Hölscher, C.},
  title   = {{Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2010.02.014},
  pmid    = {20359773},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2010.02.014}
}

@article{duffy2013-23103794,
  author  = {Duffy, A. M. and Hölscher, C.},
  title   = {{The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease}},
  journal = {Neuroscience},
  year    = {2013},
  doi     = {10.1016/j.neuroscience.2012.10.045},
  pmid    = {23103794},
  url     = {https://doi.org/10.1016/j.neuroscience.2012.10.045}
}

@article{ghosal2009-19837693,
  author  = {Ghosal, K. and Vogt, D. L. and Liang, M. and Shen, Y. and Lamb, B. T. and Pimplikar, S. W.},
  title   = {{Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0907652106},
  pmid    = {19837693},
  url     = {https://doi.org/10.1073/pnas.0907652106}
}

@article{matsumoto2026-cd287502,
  author  = {Matsumoto, N. and Choi, H. and Freda, P. J. and Hernandez, M. E. and Wang, Z. P. and Moore, J. H.},
  title   = {{EcoXAI: Autonomous Agentic Ecosystem for Explainable Artificial Intelligence and Biomedical Discovery}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.08.737358},
  url     = {https://doi.org/10.64898/2026.07.08.737358}
}