% alzhub.org library filter % Source: https://alzhub.org/research?score_min=67&about=clinical-trials % 500 entries, in the order the page lists them. Built from alzhub.org's own records. % 1 entries have no readable author in the source record and carry no author field. @article{brodaty2025-39875685, author = {Brodaty, Henry and Chau, Tiffany and Heffernan, Megan and Ginige, Jeewani A and Andrews, Gavin and Millard, Michael and Sachdev, Perminder S and Anstey, Kaarin J and others}, title = {{An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: a randomized controlled trial}}, journal = {Nature medicine}, year = {2025}, doi = {10.1038/s41591-024-03351-6}, pmid = {39875685}, url = {https://doi.org/10.1038/s41591-024-03351-6} } @article{qi2026-41478817, author = {Qi, L. and Zheng, F. and Tu, M. and Abdullah, R. and Zhao, Y. and Su, X. and Zhou, D. and Peng, G.}, title = {{Safety profiles of lecanemab: A systematic review and meta-analysis of randomized controlled trials and real-world evidence}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2026}, doi = {10.1016/j.tjpad.2025.100473}, pmid = {41478817}, url = {https://doi.org/10.1016/j.tjpad.2025.100473} } @article{pascuallucas2025-41058018, author = {Pascual-Lucas, M. and Lacosta, A. M. and Montañés, M. and Canudas, J. and Loscos, J. and Monleón, I. and Allué, J. A. and Sarasa, L. and others}, title = {{Safety, tolerability, immunogenicity, and efficacy of ABvac40 active immunotherapy against Aβ40 in patients with mild cognitive impairment or very mild Alzheimer's disease: A randomized, double-blind, placebo-controlled phase 2 study}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70776}, pmid = {41058018}, url = {https://doi.org/10.1002/alz.70776} } @article{asada2025-40302041, author = {Asada, Takashi and Thanasopoulou, Angeliki and Delmar, Paul and Wojtowicz, Jakub and Smith, Janice and Yoshiyama, Yasumasa and Yokoi, Katsunori and Watanabe, Chigusa and others}, title = {{Japanese participant data from three gantenerumab trials in early Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70192}, pmid = {40302041}, url = {https://doi.org/10.1002/alz.70192} } @article{edwards2017-29201994, author = {Edwards, J. D. and Xu, H. and Clark, D. O. and Guey, L. T. and Ross, L. A. and Unverzagt, F. W.}, title = {{Speed of processing training results in lower risk of dementia}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2017}, doi = {10.1016/j.trci.2017.09.002}, pmid = {29201994}, url = {https://doi.org/10.1016/j.trci.2017.09.002} } @article{oki2024-39229900, author = {Oki, Y. and Osaki, T. and Kumagai, R. and Murata, S. and Encho, H. and Ono, R. and Yasuda, H. and Kowa, H.}, title = {{An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.14170}, pmid = {39229900}, url = {https://doi.org/10.1002/alz.14170} } @article{salloway2025-40390253, author = {Salloway, S. and Pain, A. and Lee, E. and Papka, M. and Ferguson, M. B. and Wang, H. and Hu, H. and Lu, M. and others}, title = {{TRAILBLAZER-ALZ 4: A phase 3 trial comparing donanemab with aducanumab on amyloid plaque clearance in early, symptomatic Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2025}, doi = {10.1002/alz.70293}, pmid = {40390253}, url = {https://doi.org/10.1002/alz.70293} } @article{shulman2023-38012285, author = {Shulman, M. and Kong, J. and O'Gorman, J. and Ratti, E. and Rajagovindan, R. and Viollet, L. and Huang, E. and Sharma, S. and others}, title = {{TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease}}, journal = {Nature aging}, year = {2023}, doi = {10.1038/s43587-023-00523-w}, pmid = {38012285}, url = {https://doi.org/10.1038/s43587-023-00523-w} } @article{brown2024-38629936, author = {Brown, Robin B and Tozer, Daniel J and Loubière, Laurence and Harshfield, Eric L and Hong, Young T and Fryer, Tim D and Williams, Guy B and Graves, Martin J and others}, title = {{MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13830}, pmid = {38629936}, url = {https://doi.org/10.1002/alz.13830} } @article{kim2026-42475653, author = {Kim, Da Ae and Lee, Sun Min and Sun, Kyunghwa and Park, Ji Hyun and Park, Yoo Kyoung and Jeong, Jee Hyang and Hong, Chang Hyung and Jung, Jiwoo and others}, title = {{Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial}}, journal = {Neurology}, year = {2026}, doi = {10.1212/wnl.0000000000218297}, pmid = {42475653}, url = {https://doi.org/10.1212/wnl.0000000000218297} } @article{sharma2026-42434897, author = {Sharma, A. and Suresh, V. and Kola, P. R. and Raj, R. and Javairia, F. and Nithyanandam, A. and Kaur, A. and Arora, H. and others}, title = {{Comparative risk of amyloid-related imaging abnormalities with anti-amyloid-β monoclonal antibodies: A systematic review and penalized likelihood network meta-analysis of randomized trials}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2026}, doi = {10.1177/13872877261466097}, pmid = {42434897}, url = {https://doi.org/10.1177/13872877261466097} } @article{barnes2023-37466280, author = {Barnes, L. L. and Dhana, K. and Liu, X. and Carey, V. J. and Ventrelle, J. and Johnson, K. and others}, title = {{Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons}}, journal = {New England Journal of Medicine}, year = {2023}, doi = {10.1056/NEJMoa2302368}, pmid = {37466280}, url = {https://doi.org/10.1056/NEJMoa2302368} } @article{pascuallucas2026-42590850, author = {Pascual-Lucas, M. and Lacosta, A. M. and Montañés, M. and Canudas, J. and Loscos, J. and Monleón, I. and Allué, J. A. and Sarasa, L. and others}, title = {{Long-term safety and immunogenicity of ABvac40 active immunotherapy in mild cognitive impairment and very mild Alzheimer's disease: Results from AB1601 phase 2 extension study}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71746}, pmid = {42590850}, url = {https://doi.org/10.1002/alz.71746} } @article{tariot2026-41579901, author = {Tariot, Pierre N and Lopera, Francisco S and Ríos-Romenets, Silvia and Sink, Kaycee M and Giraldo-Chica, Margarita and Acosta-Baena, Natalia and Villegas, Gustavo and Espinosa, Alejandro and others}, title = {{Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial}}, journal = {The Lancet. Neurology}, year = {2026}, doi = {10.1016/s1474-4422(25)00426-0}, pmid = {41579901}, url = {https://doi.org/10.1016/s1474-4422(25)00426-0} } @article{banerjee2021-34688369, author = {Banerjee, Sube and High, Juliet and Stirling, Susan and Shepstone, Lee and Swart, Ann Marie and Telling, Tanya and Henderson, Catherine and Ballard, Clive and others}, title = {{Study of mirtazapine for agitated behaviours in dementia (SYMBAD): a randomised, double-blind, placebo-controlled trial}}, journal = {Lancet (London, England)}, year = {2021}, doi = {10.1016/s0140-6736(21)01210-1}, pmid = {34688369}, url = {https://doi.org/10.1016/s0140-6736(21)01210-1} } @article{vijverberg2026-41930592, author = {Vijverberg, Everard G B and Scharre, Douglas W and Woodward, Michael and Catalano, Susan and Hamby, Mary E and Grundman, Michael and Morgan, Roger E and Iaci, Jennifer and others}, title = {{Randomized, double-blind study of zervimesine in mild to moderate Alzheimer's disease}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2026}, doi = {10.1177/13872877261437145}, pmid = {41930592}, url = {https://doi.org/10.1177/13872877261437145} } @article{gardener2024-38596483, author = {Gardener, S. L. and Fuller, S. J. and Naismith, S. L. and Baker, L. and Kivipelto, M. and Villemagne, V. L. and Grieve, S. M. and Yates, P. and others}, title = {{The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial}}, journal = {Alzheimer's \& dementia (New York, N. Y.)}, year = {2024}, doi = {10.1002/trc2.12466}, pmid = {38596483}, url = {https://doi.org/10.1002/trc2.12466} } @article{hey2026-42678603, author = {Hey, J. A. and Abushakra, S. and Power, A. and Watson, D. and Porsteinsson, A. and Sabbagh, M. and MacSweeney, E. and Cohen, S. and others}, title = {{Plasma Biomarker Effects of Oral Valiltramiprosate/ALZ-801 in Early Alzheimer's Disease from Phase 3 and Phase 2 Trials: Analysis of Core Biomarkers and Correlations with Clinical and Neuroimaging Outcomes}}, journal = {Drugs}, year = {2026}, doi = {10.1007/s40265-026-02381-3}, pmid = {42678603}, url = {https://doi.org/10.1007/s40265-026-02381-3} } @article{hughes2020-32427305, author = {Hughes, D. and Judge, C. and Murphy, R. and Loughlin, E. and Costello, M. and Whiteley, W. and others}, title = {{Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis}}, journal = {JAMA}, year = {2020}, doi = {10.1001/jama.2020.4249}, pmid = {32427305}, url = {https://doi.org/10.1001/jama.2020.4249} } @article{salloway2014-24450891, author = {Salloway, S. and Sperling, R. and Fox, N. C. and Blennow, K. and Klunk, W. and Raskind, M. and Sabbagh, M. and Honig, L. S. and others}, title = {{Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease}}, journal = {The New England journal of medicine}, year = {2014}, doi = {10.1056/nejmoa1304839}, pmid = {24450891}, url = {https://doi.org/10.1056/nejmoa1304839} } @article{ngandu2015-25771249, author = {Ngandu, T. and Lehtisalo, J. and Solomon, A. and Levälahti, E. and Ahtiluoto, S. and Antikainen, R. and Bäckman, L. and Hänninen, T. and others}, title = {{A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial}}, journal = {Lancet (London, England)}, year = {2015}, doi = {10.1016/s0140-6736(15)60461-5}, pmid = {25771249}, url = {https://doi.org/10.1016/s0140-6736(15)60461-5} } @article{courtright2024-38227032, author = {Courtright, K. R. and Madden, V. and Bayes, B. and Chowdhury, M. and Whitman, C. and Small, D. S. and Harhay, M. O. and Parra, S. and others}, title = {{Default Palliative Care Consultation for Seriously Ill Hospitalized Patients: A Pragmatic Cluster Randomized Trial}}, journal = {JAMA}, year = {2024}, doi = {10.1001/jama.2023.25092}, pmid = {38227032}, url = {https://doi.org/10.1001/jama.2023.25092} } @article{bauer2019-30821830, author = {Bauer, M. S. and Miller, C. J. and Kim, B. and Lew, R. and Stolzmann, K. and Sullivan, J. and Riendeau, R. and Pitcock, J. and others}, title = {{Effectiveness of Implementing a Collaborative Chronic Care Model for Clinician Teams on Patient Outcomes and Health Status in Mental Health: A Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.0230}, pmid = {30821830}, url = {https://doi.org/10.1001/jamanetworkopen.2019.0230} } @article{cullen2024-38101301, author = {Cullen, Nicholas C and Novak, Petr and Tosun, Duygu and Kovacech, Branislav and Hanes, Jozef and Kontsekova, Eva and Fresser, Michal and Ropele, Stefan and others}, title = {{Efficacy assessment of an active tau immunotherapy in Alzheimer's disease patients with amyloid and tau pathology: a post hoc analysis of the "ADAMANT" randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trial}}, journal = {EBioMedicine}, year = {2024}, doi = {10.1016/j.ebiom.2023.104923}, pmid = {38101301}, url = {https://doi.org/10.1016/j.ebiom.2023.104923} } @article{holper2026-41980907, author = {Holper, Sarah and Barnham, Kevin J and Churilov, Leonid and Yates, Paul and Brodtmann, Amy and Johns, Sally and Li, Qia-Xin and Bhalala, Oneil and others}, title = {{A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71381}, pmid = {41980907}, url = {https://doi.org/10.1002/alz.71381} } @article{burns2021-34146512, author = {Burns, Daniel K and Alexander, Robert C and Welsh-Bohmer, Kathleen A and Culp, Meredith and Chiang, Carl and O'Neil, Janet and Evans, Rebecca M and Harrigan, Patrick and others}, title = {{Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial}}, journal = {The Lancet. Neurology}, year = {2021}, doi = {10.1016/s1474-4422(21)00043-0}, pmid = {34146512}, url = {https://doi.org/10.1016/s1474-4422(21)00043-0} } @article{lin2023-37478886, author = {Lin, F. R. and Pike, JR. and Albert, M. S. and Arnold, M. and Burgard, S. and Chisolm, T. and Couper, D. and Deal, J. A. and others}, title = {{Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial}}, journal = {Lancet (London, England)}, year = {2023}, doi = {10.1016/s0140-6736(23)01406-x}, pmid = {37478886}, url = {https://doi.org/10.1016/s0140-6736(23)01406-x} } @article{sakurai2024-38646854, author = {Sakurai, T. and Sugimoto, T. and Akatsu, H. and Doi, T. and Fujiwara, Y. and Hirakawa, A. and Kinoshita, F. and Kuzuya, M. and others}, title = {{Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13838}, pmid = {38646854}, url = {https://doi.org/10.1002/alz.13838} } @article{lehtisalo2022-35051281, author = {Lehtisalo, J. and Rusanen, M. and Solomon, A. and Antikainen, R. and Laatikainen, T. and Peltonen, M. and Strandberg, T. and Tuomilehto, J. and others}, title = {{Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial}}, journal = {European heart journal}, year = {2022}, doi = {10.1093/eurheartj/ehab922}, pmid = {35051281}, url = {https://doi.org/10.1093/eurheartj/ehab922} } @article{lenze2022-36511926, author = {Lenze, E. J. and Voegtle, M. and Miller, J. P. and Ances, B. M. and Balota, D. A. and Barch, D. and Depp, C. A. and Diniz, B. S. and others}, title = {{Effects of Mindfulness Training and Exercise on Cognitive Function in Older Adults: A Randomized Clinical Trial}}, journal = {JAMA}, year = {2022}, doi = {10.1001/jama.2022.21680}, pmid = {36511926}, url = {https://doi.org/10.1001/jama.2022.21680} } @article{macfarlane2025-39800452, author = {Macfarlane, S. and Grimmer, T. and Teo, K. and O'Brien, T. J. and Woodward, M. and Grunfeld, J. and Mander, A. and Brodtmann, A. and others}, title = {{Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2025}, doi = {10.1016/j.tjpad.2024.100016}, pmid = {39800452}, url = {https://doi.org/10.1016/j.tjpad.2024.100016} } @article{chandler2019-31099860, author = {Chandler, M. J. and Locke, D. E. and Crook, J. E. and Fields, J. A. and Ball, C. T. and Phatak, V. S. and Dean, P. M. and Morris, M. and others}, title = {{Comparative Effectiveness of Behavioral Interventions on Quality of Life for Older Adults With Mild Cognitive Impairment: A Randomized Clinical Trial}}, journal = {JAMA network open}, year = {2019}, doi = {10.1001/jamanetworkopen.2019.3016}, pmid = {31099860}, url = {https://doi.org/10.1001/jamanetworkopen.2019.3016} } @article{toda2024-39350371, author = {Toda, Y. and Iwatsubo, T. and Nakamura, Y. and Matsuda, N. and Miyata, M. and Jin, M. and Chen, T. and Kuribayashi, K. and others}, title = {{Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer's Disease}}, journal = {The journal of prevention of Alzheimer's disease}, year = {2024}, doi = {10.14283/jpad.2024.106}, pmid = {39350371}, url = {https://doi.org/10.14283/jpad.2024.106} } @article{kutzsche2025-40324978, author = {Kutzsche, J. and Cosma, N. 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Healthy longevity}, year = {2021}, doi = {10.1016/s2666-7568(21)00173-2}, pmid = {34522910}, url = {https://doi.org/10.1016/s2666-7568(21)00173-2} } @article{vanasbroeck2024-38759017, author = {Van Asbroeck, Stephanie and Köhler, Sebastian and Wimmers, Sophie C P M and Muris, Jean W M and van Boxtel, Martin P J and Deckers, Kay}, title = {{Multidomain Dementia Risk Reduction in Primary Care is Feasible: A Proof-of-concept study}}, journal = {Journal of Alzheimer's disease : JAD}, year = {2024}, doi = {10.3233/jad-240229}, pmid = {38759017}, url = {https://doi.org/10.3233/jad-240229} } @article{abdelhaleem2026-40435316, author = {Abdel-Haleem, Alyaa M and Casavant, Ellen and Toth, Balazs and Teng, Edmond and Monteiro, Cecilia and Pandya, Nikhil J and Glock, Caspar and Hoogenraad, Casper C and others}, title = {{CSF proteomics of semorinemab Alzheimer's disease trials identifies cell-type specific signatures}}, journal = {Brain : a journal of neurology}, year = {2026}, doi = {10.1093/brain/awaf200}, pmid = {40435316}, url = {https://doi.org/10.1093/brain/awaf200} } @article{mehta2017-28832937, author = {Mehta, Nishila and Rodrigues, Craig and Lamba, Manpreet and Wu, Wei and Bronskill, Susan E and Herrmann, Nathan and Gill, Sudeep S and Chan, An-Wen and others}, title = {{Systematic Review of Sex-Specific Reporting of Data: Cholinesterase Inhibitor Example}}, journal = {Journal of the American Geriatrics Society}, year = {2017}, doi = {10.1111/jgs.15020}, pmid = {28832937}, url = {https://doi.org/10.1111/jgs.15020} } @article{martens2026-42478598, author = {Martens, Christopher R and Decker, Kevin P and DeConne, Theodore M and Sanjana, Faria and Horvat, Fiona and Rizzi, Nicholas A and Awad, Catherine and Habash, Elizabeth and others}, title = {{A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71605}, pmid = {42478598}, url = {https://doi.org/10.1002/alz.71605} } @article{saadmaan2024-38647197, author = {Saadmaan, Gazi and Dalmasso, Maria Carolina and Ramirez, Alfredo and Hiltunen, Mikko and Kemppainen, Nina and Lehtisalo, Jenni and Mangialasche, Francesca and Ngandu, Tiia and others}, title = {{Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2024}, doi = {10.1002/alz.13843}, pmid = {38647197}, url = {https://doi.org/10.1002/alz.13843} } @article{simone2024-37930366, author = {Simone, Tamar and Peltz, Carrie and Rosenberg, Dori E and Barnes, Deborah E and Fleckenstein, Lynn E and Dublin, Sascha and Yaffe, Kristine}, title = {{The Impact of Pandemic-Related Restrictions on Dementia Risk Factors in Older Adults}}, journal = {Journal of applied gerontology : the official journal of the Southern Gerontological Society}, year = {2024}, doi = {10.1177/07334648231210671}, pmid = {37930366}, url = {https://doi.org/10.1177/07334648231210671} } @article{herring2020-31944580, author = {Herring, W Joseph and Ceesay, Paulette and Snyder, Ellen and Bliwise, Donald and Budd, Kerry and Hutzelmann, Jill and Stevens, Joanne and Lines, Christopher and others}, title = {{Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial}}, journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association}, year = {2020}, doi = {10.1002/alz.12035}, pmid = {31944580}, url = {https://doi.org/10.1002/alz.12035} } @article{ljubenkov2021-34559230, author = {Ljubenkov, P. 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