% alzhub.org library filter
% Source: https://alzhub.org/research?category=drug_development&about=clinical-trials
% 79 entries, in the order the page lists them. Built from alzhub.org's own records.
% 1 entries have no readable author in the source record and carry no author field.

@article{shulman2023-38012285,
  author  = {Shulman, M. and Kong, J. and O'Gorman, J. and Ratti, E. and Rajagovindan, R. and Viollet, L. and Huang, E. and Sharma, S. and others},
  title   = {{TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease}},
  journal = {Nature aging},
  year    = {2023},
  doi     = {10.1038/s43587-023-00523-w},
  pmid    = {38012285},
  url     = {https://doi.org/10.1038/s43587-023-00523-w}
}

@article{abdelhaleem2026-40435316,
  author  = {Abdel-Haleem, Alyaa M and Casavant, Ellen and Toth, Balazs and Teng, Edmond and Monteiro, Cecilia and Pandya, Nikhil J and Glock, Caspar and Hoogenraad, Casper C and others},
  title   = {{CSF proteomics of semorinemab Alzheimer's disease trials identifies cell-type specific signatures}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awaf200},
  pmid    = {40435316},
  url     = {https://doi.org/10.1093/brain/awaf200}
}

@article{biessels2019-31399442,
  author  = {Biessels, G. J. and Verhagen, C. and Janssen, J. and van den Berg, E. and Zinman, B. and Rosenstock, J. and George, J. T. and Passera, A. and others},
  title   = {{Effect of Linagliptin on Cognitive Performance in Patients With Type 2 Diabetes and Cardiorenal Comorbidities: The CARMELINA Randomized Trial}},
  journal = {Diabetes care},
  year    = {2019},
  doi     = {10.2337/dc19-0783},
  pmid    = {31399442},
  url     = {https://doi.org/10.2337/dc19-0783}
}

@article{burns2025-40566796,
  author  = {Burns, Jeffrey M and Morris, Jill K and Vidoni, Eric D and Wilkins, Heather M and Choi, In-Young and Lee, Phil and Hunt, Suzanne L and Mahnken, Jonathan D and others},
  title   = {{Effects of the SGLT2 inhibitor dapagliflozin in early Alzheimer's disease: A randomized controlled trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70416},
  pmid    = {40566796},
  url     = {https://doi.org/10.1002/alz.70416}
}

@article{devanand2022-34059401,
  author  = {Devanand, D P and Crocco, Elizabeth and Forester, Brent P and Husain, Mustafa M and Lee, Seonjoo and Vahia, Ipsit V and Andrews, Howard and Simon-Pearson, Laura and others},
  title   = {{Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease: Lit-AD Randomized Clinical Trial}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2022},
  doi     = {10.1016/j.jagp.2021.04.014},
  pmid    = {34059401},
  url     = {https://doi.org/10.1016/j.jagp.2021.04.014}
}

@article{gauthier2016-27863809,
  author  = {Gauthier, S. and Feldman, H. H. and Schneider, L. S. and Wilcock, G. K. and Frisoni, G. B. and Hardlund, J. H. and Moebius, H. J. and others},
  title   = {{Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial}},
  journal = {Lancet (London, England)},
  year    = {2016},
  doi     = {10.1016/s0140-6736(16)31275-2},
  pmid    = {27863809},
  url     = {https://doi.org/10.1016/s0140-6736(16)31275-2}
}

@article{fang2021-35572351,
  author  = {Fang, J. and Zhang, P. and Zhou, Y. and Chiang, C. W. and Tan, J. and Hou, Y. and Stauffer, S. and Li, L. and others},
  title   = {{Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease}},
  journal = {Nature aging},
  year    = {2021},
  doi     = {10.1038/s43587-021-00138-z},
  pmid    = {35572351},
  url     = {https://doi.org/10.1038/s43587-021-00138-z}
}

@article{cas2024-38565814,
  author  = {Cas, A Dei and Micheli, M M and Aldigeri, R and Gardini, S and Ferrari-Pellegrini, F and Perini, M and Messa, G and Antonini, M and others},
  title   = {{Long-acting exenatide does not prevent cognitive decline in mild cognitive impairment: a proof-of-concept clinical trial}},
  journal = {Journal of endocrinological investigation},
  year    = {2024},
  doi     = {10.1007/s40618-024-02320-7},
  pmid    = {38565814},
  url     = {https://doi.org/10.1007/s40618-024-02320-7}
}

@article{koychev2024-39358806,
  author  = {Koychev, Ivan and Reid, Graham and Nguyen, Maggie and Mentz, Robert J and Joyce, Dan and Shah, Svati H and Holman, Rury R},
  title   = {{Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01573-x},
  pmid    = {39358806},
  url     = {https://doi.org/10.1186/s13195-024-01573-x}
}

@article{simons2002-12205648,
  author  = {Simons, M. and Schwärzler, F. and Lütjohann, D. and von Bergmann, K. and Beyreuther, K. and Dichgans, J. and Wormstall, H. and Hartmann, T. and others},
  title   = {{Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial}},
  journal = {Annals of neurology},
  year    = {2002},
  doi     = {10.1002/ana.10292},
  pmid    = {12205648},
  url     = {https://doi.org/10.1002/ana.10292}
}

@article{ott2015-25575908,
  author  = {Ott, B. R. and Daiello, L. A. and Dahabreh, I. J. and Springate, B. A. and Bixby, K. and Murali, M. and Trikalinos, T. A.},
  title   = {{Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials}},
  journal = {Journal of general internal medicine},
  year    = {2015},
  doi     = {10.1007/s11606-014-3115-3},
  pmid    = {25575908},
  url     = {https://doi.org/10.1007/s11606-014-3115-3}
}

@article{forlenza2019-30947755,
  author  = {Forlenza, Orestes V and Radanovic, Márcia and Talib, Leda L and Gattaz, Wagner F},
  title   = {{Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2019},
  doi     = {10.1192/bjp.2019.76},
  pmid    = {30947755},
  url     = {https://doi.org/10.1192/bjp.2019.76}
}

@article{norgaard2022-35229024,
  author  = {Nørgaard, C. H. and Friedrich, S. and Hansen, C. T. and Gerds, T. and Ballard, C. and Møller, D. V. and Knudsen, L. B. and Kvist, K. and others},
  title   = {{Treatment with glucagon-like peptide-1 receptor agonists and incidence of dementia: Data from pooled double-blind randomized controlled trials and nationwide disease and prescription registers}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12268},
  pmid    = {35229024},
  url     = {https://doi.org/10.1002/trc2.12268}
}

@article{luchsinger2016-26890736,
  author  = {Luchsinger, J. A. and Perez, T. and Chang, H. and Mehta, P. and Steffener, J. and Pradabhan, G. and Ichise, M. and Manly, J. and others},
  title   = {{Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2016},
  doi     = {10.3233/jad-150493},
  pmid    = {26890736},
  url     = {https://doi.org/10.3233/jad-150493}
}

@article{avilesolmos2014-24662192,
  author  = {Aviles-Olmos, I. and Dickson, J. and Kefalopoulou, Z. and Djamshidian, A. and Kahan, J. and Ell, P. and Whitton, P. and Wyse, R. and others},
  title   = {{Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease}},
  journal = {Journal of Parkinson's disease},
  year    = {2014},
  doi     = {10.3233/jpd-140364},
  pmid    = {24662192},
  url     = {https://doi.org/10.3233/jpd-140364}
}

@article{forlenza2011-21525519,
  author  = {Forlenza, O. V. and Diniz, B. S. and Radanovic, M. and Santos, F. S. and Talib, L. L. and Gattaz, W. F.},
  title   = {{Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial}},
  journal = {The British journal of psychiatry : the journal of mental science},
  year    = {2011},
  doi     = {10.1192/bjp.bp.110.080044},
  pmid    = {21525519},
  url     = {https://doi.org/10.1192/bjp.bp.110.080044}
}

@article{wagstaff2003-12885101,
  author  = {Wagstaff, L. R. and Mitton, M. W. and Arvik, B. M. and Doraiswamy, P. M.},
  title   = {{Statin-associated memory loss: analysis of 60 case reports and review of the literature}},
  journal = {Pharmacotherapy},
  year    = {2003},
  doi     = {10.1592/phco.23.7.871.32720},
  pmid    = {12885101},
  url     = {https://doi.org/10.1592/phco.23.7.871.32720}
}

@article{araki2020-7f71ce0b,
  author  = {Araki, Eiichi and Goto, Atsushi and Kondo, Tatsuya and Noda, Mitsuhiko and Noto, Hiroshi and Origasa, Hideki and Osawa, Haruhiko and Taguchi, Akihiko and others},
  title   = {{Japanese Clinical Practice Guideline for Diabetes 2019}},
  journal = {Journal of Diabetes Investigation},
  year    = {2020},
  doi     = {10.1111/jdi.13306},
  url     = {https://doi.org/10.1111/jdi.13306}
}

@article{ioakeimskoufa2023-37296934,
  author  = {Ioakeim-Skoufa, Ignatios and Tobajas-Ramos, Natalia and Menditto, Enrica and Aza-Pascual-Salcedo, Mercedes and Gimeno-Miguel, Antonio and Orlando, Valentina and González-Rubio, Francisca and Fanlo-Villacampa, Ana and others},
  title   = {{Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials}},
  journal = {Cancers},
  year    = {2023},
  doi     = {10.3390/cancers15112972},
  pmid    = {37296934},
  url     = {https://doi.org/10.3390/cancers15112972}
}

@article{jeong2022-36038268,
  author  = {Jeong, S. Y. and Suh, C. H. and Shim, W. H. and Lim, J. S. and Lee, J. H. and Kim, S. J.},
  title   = {{Incidence of Amyloid-Related Imaging Abnormalities in Patients With Alzheimer Disease Treated With Anti-β-Amyloid Immunotherapy: A Meta-analysis}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000201019},
  pmid    = {36038268},
  url     = {https://doi.org/10.1212/wnl.0000000000201019}
}

@article{gilbert2018-30508430,
  author  = {Gilbert, Matthew Philip and Bain, Stephen Charles and Franek, Edward and Jódar-Gimeno, Esteban and Nauck, Michael Albrecht and Pratley, Richard E. and Rea, Rosangela Roginski and Saraiva, José Francisco Kerr and others},
  title   = {{Effect of Liraglutide on Cardiovascular Outcomes in Elderly Patients: A Post Hoc Analysis of a Randomized Controlled Trial}},
  journal = {Annals of Internal Medicine},
  year    = {2018},
  doi     = {10.7326/m18-1569},
  pmid    = {30508430},
  url     = {https://doi.org/10.7326/m18-1569}
}

@article{mullins2019-31518224,
  author  = {Mullins, R. J. and Mustapic, M. and Chia, C. W. and Carlson, O. and Gulyani, S. and Tran, J. and Li, Y. and Mattson, M. P. and others},
  title   = {{A Pilot Study of Exenatide Actions in Alzheimer's Disease}},
  journal = {Current Alzheimer research},
  year    = {2019},
  doi     = {10.2174/1567205016666190913155950},
  pmid    = {31518224},
  url     = {https://doi.org/10.2174/1567205016666190913155950}
}

@article{hampel2009-19573486,
  author  = {Hampel, H. and Ewers, M. and Bürger, K. and Annas, P. and Mörtberg, A. and Bogstedt, A. and Frölich, L. and Schröder, J. and others},
  title   = {{Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study}},
  journal = {The Journal of clinical psychiatry},
  year    = {2009},
  pmid    = {19573486}
}

@article{schauer2024-39513754,
  author  = {Schauer, Stephen P and Toth, Balazs and Lee, Julie and Honigberg, Lee A and Ramakrishnan, Vidya and Jiang, Jenny and Kollmorgen, Gwendlyn and Bayfield, Anna and others},
  title   = {{Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14346},
  pmid    = {39513754},
  url     = {https://doi.org/10.1002/alz.14346}
}

@article{saito2016-29067312,
  author  = {Saito, Satoshi and Kojima, Shinsuke and Oishi, Naoya and Kakuta, Ryosuke and Maki, Takakuni and Yasuno, Fumihiko and Nagatsuka, Kazuyuki and Yamamoto, Haruko and others},
  title   = {{A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2016},
  doi     = {10.1016/j.trci.2016.10.001},
  pmid    = {29067312},
  url     = {https://doi.org/10.1016/j.trci.2016.10.001}
}

@article{jeremic2025-40194268,
  author  = {Jeremic, D. and Navarro-Lopez, J. D. and Jimenez-Diaz, L.},
  title   = {{Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application}},
  journal = {Journal of medical Internet research},
  year    = {2025},
  doi     = {10.2196/68454},
  pmid    = {40194268},
  url     = {https://doi.org/10.2196/68454}
}

@article{baddeley2015-25320049,
  author  = {Baddeley, T. C. and McCaffrey, J. and Storey, J. M. and Cheung, J. K. and Melis, V. and Horsley, D. and Harrington, C. R. and Wischik, C. M.},
  title   = {{Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer's disease}},
  journal = {The Journal of pharmacology and experimental therapeutics},
  year    = {2015},
  doi     = {10.1124/jpet.114.219352},
  pmid    = {25320049},
  url     = {https://doi.org/10.1124/jpet.114.219352}
}

@article{tang2024-39429814,
  author  = {Tang, Bowen and Sjölander, Arvid and Wastesson, Jonas W. and Maura, Géric and Blotière, Pierre‐Olivier and Szilcz, Máté and Mak, Jonathan K. L. and Qin, Chenxi and others},
  title   = {{Comparative effectiveness of glucagon-like peptide-1 agonists, dipeptidyl peptidase-4 inhibitors, and sulfonylureas on the risk of dementia in older individuals with type 2 diabetes in Sweden: an emulated trial study}},
  journal = {EClinicalMedicine},
  year    = {2024},
  doi     = {10.1016/j.eclinm.2024.102689},
  pmid    = {39429814},
  url     = {https://doi.org/10.1016/j.eclinm.2024.102689}
}

@article{loomis2024-38165296,
  author  = {Loomis, S. J. and Miller, R. and Castrillo-Viguera, C. and Umans, K. and Cheng, W. and O'Gorman, J. and Hughes, R. and Budd Haeberlein, S. and others},
  title   = {{Genome-Wide Association Studies of ARIA From the Aducanumab Phase 3 ENGAGE and EMERGE Studies}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000207919},
  pmid    = {38165296},
  url     = {https://doi.org/10.1212/wnl.0000000000207919}
}

@article{femminella2019-30944040,
  author  = {Femminella, G. D. and Frangou, E. and Love, S. B. and Busza, G. and Holmes, C. and Ritchie, C. and Lawrence, R. and McFarlane, B. and others},
  title   = {{Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study)}},
  journal = {Trials},
  year    = {2019},
  doi     = {10.1186/s13063-019-3259-x},
  pmid    = {30944040},
  url     = {https://doi.org/10.1186/s13063-019-3259-x}
}

@article{gejl2016-27252647,
  author  = {Gejl, M. and Gjedde, A. and Egefjord, L. and Møller, A. and Hansen, S. B. and Vang, K. and Rodell, A. and Brændgaard, H. and others},
  title   = {{In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial}},
  journal = {Frontiers in aging neuroscience},
  year    = {2016},
  doi     = {10.3389/fnagi.2016.00108},
  pmid    = {27252647},
  url     = {https://doi.org/10.3389/fnagi.2016.00108}
}

@article{cummings2022-35516416,
  author  = {Cummings, J. and Lee, G. and Nahed, P. and Kambar, M. E. Z. N. and Zhong, K. and Fonseca, J. and Taghva, K.},
  title   = {{Alzheimer's disease drug development pipeline: 2022}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2022},
  doi     = {10.1002/trc2.12295},
  pmid    = {35516416},
  url     = {https://doi.org/10.1002/trc2.12295}
}

@article{cummings2024-38659717,
  author  = {Cummings, J. and Zhou, Y. and Lee, G. and Zhong, K. and Fonseca, J. and Cheng, F.},
  title   = {{Alzheimer's disease drug development pipeline: 2024}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2024},
  doi     = {10.1002/trc2.12465},
  pmid    = {38659717},
  url     = {https://doi.org/10.1002/trc2.12465}
}

@article{moore2026-42268602,
  author  = {Moore, Gregory J and Bose, Niranjan and Henter, Ioline D and Manji, Husseini K},
  title   = {{The 25-Year Evolution of Lithium as a Disease-Modifying Agent in Dementia: A Narrative Review}},
  journal = {JAMA psychiatry},
  year    = {2026},
  doi     = {10.1001/jamapsychiatry.2026.1296},
  pmid    = {42268602},
  url     = {https://doi.org/10.1001/jamapsychiatry.2026.1296}
}

@article{brown2026-42437499,
  author  = {Brown, C. A. and Robinson, J. L. and Das, SR. and McGrew, E. and Suh, E. and Van Deerlin, V. M. and Irwin, D. J. and Nasrallah, I. M. and others},
  title   = {{Clinicopathologic Evaluation of Amyloid Clearance in Alzheimer Disease}},
  journal = {JAMA},
  year    = {2026},
  doi     = {10.1001/jama.2026.13058},
  pmid    = {42437499},
  url     = {https://doi.org/10.1001/jama.2026.13058}
}

@article{ramakrishnan2024-39350369,
  author  = {Ramakrishnan, V and Bender, B and Langenhorst, J and Magnusson, M O and Dolton, M and Shim, J and Fuji, R N and Monteiro, C and others},
  title   = {{Semorinemab Pharmacokinetics and The Effect on Plasma Total Tau Pharmacodynamics in Clinical Studies}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2024},
  doi     = {10.14283/jpad.2024.146},
  pmid    = {39350369},
  url     = {https://doi.org/10.14283/jpad.2024.146}
}

@article{kannel1964-14233810,
  author  = {Kannel, William Bernard and Dawber, Thomas R. and FRIEDMAN, GARY D. and GLENNON, WILLIAM E. and MCNAMARA, PATRICIA M.},
  title   = {{Risk Factors in Coronary Heart Disease}},
  journal = {Annals of Internal Medicine},
  year    = {1964},
  doi     = {10.7326/0003-4819-61-5-888},
  pmid    = {14233810},
  url     = {https://doi.org/10.7326/0003-4819-61-5-888}
}

@article{huang2023-37784171,
  author  = {Huang, L. K. and Kuan, Y. C. and Lin, H. W. and Hu, C. J.},
  title   = {{Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update}},
  journal = {Journal of biomedical science},
  year    = {2023},
  doi     = {10.1186/s12929-023-00976-6},
  pmid    = {37784171},
  url     = {https://doi.org/10.1186/s12929-023-00976-6}
}

@article{cummings2021-34095440,
  author  = {Cummings, J. and Lee, G. and Zhong, K. and Fonseca, J. and Taghva, K.},
  title   = {{Alzheimer's disease drug development pipeline: 2021}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12179},
  pmid    = {34095440},
  url     = {https://doi.org/10.1002/trc2.12179}
}

@article{panza2016-27429978,
  author  = {Panza, F. and Solfrizzi, V. and Seripa, D. and Imbimbo, B. P. and Lozupone, M. and Santamato, A. and Zecca, C. and Barulli, M. R. and others},
  title   = {{Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease}},
  journal = {BioMed research international},
  year    = {2016},
  doi     = {10.1155/2016/3245935},
  pmid    = {27429978},
  url     = {https://doi.org/10.1155/2016/3245935}
}

@article{vitek2023-36749830,
  author  = {Vitek, G. E. and Decourt, B. and Sabbagh, M. N.},
  title   = {{Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease}},
  journal = {Expert opinion on investigational drugs},
  year    = {2023},
  doi     = {10.1080/13543784.2023.2178414},
  pmid    = {36749830},
  url     = {https://doi.org/10.1080/13543784.2023.2178414}
}

@article{holscher2024-38677445,
  author  = {Hölscher, C.},
  title   = {{Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?}},
  journal = {Neuropharmacology},
  year    = {2024},
  doi     = {10.1016/j.neuropharm.2024.109952},
  pmid    = {38677445},
  url     = {https://doi.org/10.1016/j.neuropharm.2024.109952}
}

@article{west2017-29181488,
  author  = {West, T. and Hu, Y. and Verghese, P. B. and Bateman, R. J. and Braunstein, J. B. and Fogelman, I. and Budur, K. and Florian, H. and others},
  title   = {{Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies}},
  journal = {The journal of prevention of Alzheimer's disease},
  year    = {2017},
  doi     = {10.14283/jpad.2017.36},
  pmid    = {29181488},
  url     = {https://doi.org/10.14283/jpad.2017.36}
}

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