{"data_date":"2026-11-08","library_size":29380,"matched_against":"each record's title and abstract (summary field), case-insensitive","n":1393,"page":"https://alzhub.org/answers/mci-to-dementia-conversion-rate","query":"title or abstract mentions \"MCI\" or \"mild cognitive impairment\" AND \"conversion\"/\"convert\" or \"progression\"/\"progress\"","studies":[{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/tau-accumulation-and-its-spatial-progression-across-the-alzheimer-s-f5f1c357","doi":null,"journal":"Brain Communications","n_participants":832,"pmid":null,"source_url":"https://academic.oup.com/braincomms/article/6/1/fcae031/7602877","study_design":"cohort","title":"Tau accumulation and its spatial progression across the Alzheimer's disease spectrum","title_match":false,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-detects-alzheimer-pathology-d7e9adeb","doi":null,"journal":"Alzheimer's Research & Therapy","n_participants":160,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8005231/","study_design":"cohort","title":"Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment","title_match":true,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/clinical-meaningfulness-of-donanemab-in-early-symptomatic-alzheimer-42128444","doi":"10.1212/CPJ.0000000000200621","journal":"Neurology: Clinical Practice","n_participants":null,"pmid":"42128444","source_url":"https://pubmed.ncbi.nlm.nih.gov/42128444/","study_design":"phase-3-trial","title":"Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial","title_match":false,"year":2026},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/clinical-imaging-and-blood-biomarker-outcomes-in-a-phase-3-clinical-41570392","doi":"10.1016/j.tjpad.2026.100480","journal":"The Journal of Prevention of Alzheimer's Disease","n_participants":598,"pmid":"41570392","source_url":"https://pubmed.ncbi.nlm.nih.gov/41570392/","study_design":"phase-3-trial","title":"Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/lewy-body-pathology-exacerbates-brain-hypometabolism-and-cognitive-39277604","doi":"10.1038/s41467-024-52299-1","journal":"Nature Communications","n_participants":795,"pmid":"39277604","source_url":"https://pubmed.ncbi.nlm.nih.gov/39277604/","study_design":"cohort","title":"Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/cognitive-reserve-alzheimer-s-neuropathology-and-risk-of-dementia-a-33415533","doi":"10.1007/s11065-021-09478-4","journal":"Neuropsychology Review","n_participants":null,"pmid":"33415533","source_url":"https://pubmed.ncbi.nlm.nih.gov/33415533/","study_design":"meta-analysis","title":"Cognitive Reserve, Alzheimer's Neuropathology, and Risk of Dementia: A Systematic Review and Meta-Analysis","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cost-effectiveness-of-donanemab-for-early-alzheimer-disease-in-42015793","doi":"10.5694/mja2.70186","journal":"The Medical journal of Australia","n_participants":null,"pmid":"42015793","source_url":"https://pubmed.ncbi.nlm.nih.gov/42015793/","study_design":"modelling","title":"Cost-Effectiveness of Donanemab for Early Alzheimer Disease in Australia","title_match":false,"year":2026},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-tau-pet-predict-future-cognitive-decline-among-40155777","doi":"10.1038/s43587-025-00835-z","journal":"Nature Aging","n_participants":1474,"pmid":"40155777","source_url":"https://pubmed.ncbi.nlm.nih.gov/40155777/","study_design":"cohort","title":"Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-identifies-cognitively-normal-older-adults-who-will-40008832","doi":"10.1002/alz.14537","journal":"Alzheimer's & Dementia","n_participants":215,"pmid":"40008832","source_url":"https://pubmed.ncbi.nlm.nih.gov/40008832/","study_design":"cohort","title":"Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-plasma-glial-fibrillary-acidic-protein-in-41268784","doi":"10.1002/alz.70948","journal":"Alzheimer's & Dementia","n_participants":949,"pmid":"41268784","source_url":"https://pubmed.ncbi.nlm.nih.gov/41268784/","study_design":"cohort","title":"Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-economic-burden-of-subjective-cognitive-decline-mild-cognitive-40571933","doi":"10.1186/s13195-025-01785-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"40571933","source_url":"https://pubmed.ncbi.nlm.nih.gov/40571933/","study_design":"cross-sectional","title":"The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/the-social-value-of-lecanemab-for-patients-with-early-alzheimer-s-42108615","doi":"10.1177/13872877261447312","journal":"Journal of Alzheimer's Disease","n_participants":null,"pmid":"42108615","source_url":"https://pubmed.ncbi.nlm.nih.gov/42108615/","study_design":"modelling","title":"The social value of lecanemab for patients with early Alzheimer's disease in Japan","title_match":false,"year":2026},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/glymphatic-system-dysfunction-predicts-amyloid-deposition-38501315","doi":"10.1002/alz.13789","journal":"Alzheimer's & Dementia","n_participants":419,"pmid":"38501315","source_url":"https://pubmed.ncbi.nlm.nih.gov/38501315/","study_design":"cohort","title":"Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/electronic-health-records-to-test-multimorbidity-influences-to-plasma-41447112","doi":"10.1002/ana.78114","journal":"Annals of neurology","n_participants":617,"pmid":"41447112","source_url":"https://pubmed.ncbi.nlm.nih.gov/41447112/","study_design":"cross-sectional","title":"Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease","title_match":false,"year":2026},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/association-of-cerebrospinal-fluid-neurofilament-light-concentration-26524180","doi":"10.1001/jamaneurol.2015.3037","journal":"JAMA neurology","n_participants":95,"pmid":"26524180","source_url":"https://pubmed.ncbi.nlm.nih.gov/26524180/","study_design":"longitudinal study","title":"Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression","title_match":false,"year":2016},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-detects-alzheimer-pathology-33773595","doi":"10.1186/s13195-021-00804-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"33773595","source_url":"https://pubmed.ncbi.nlm.nih.gov/33773595/","study_design":"longitudinal study","title":"Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment","title_match":true,"year":2021},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-cerebrospinal-fluid-neurofilament-light-protein-levels-30508027","doi":"10.1001/jamaneurol.2018.3746","journal":"JAMA neurology","n_participants":913,"pmid":"30508027","source_url":"https://pubmed.ncbi.nlm.nih.gov/30508027/","study_design":"case-control study","title":"Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders","title_match":false,"year":2019},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-associated-with-the-apolipoprotein-e-genotype-and-22801723","doi":"10.1001/archneurol.2012.1070","journal":"Archives of neurology","n_participants":null,"pmid":"22801723","source_url":"https://pubmed.ncbi.nlm.nih.gov/22801723/","study_design":"cohort study","title":"Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/amyloid-pet-imaging-in-patients-with-mild-cognitive-impairment-a-2-21325653","doi":"10.1212/wnl.0b013e318212015e","journal":"Neurology","n_participants":null,"pmid":"21325653","source_url":"https://pubmed.ncbi.nlm.nih.gov/21325653/","study_design":null,"title":"Amyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study","title_match":false,"year":2011},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/finding-treatment-effects-in-alzheimer-trials-in-the-face-of-disease-34550903","doi":"10.1212/wnl.0000000000012022","journal":"Neurology","n_participants":302,"pmid":"34550903","source_url":"https://pubmed.ncbi.nlm.nih.gov/34550903/","study_design":null,"title":"Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity","title_match":false,"year":2021},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/an-mri-measure-of-degenerative-and-cerebrovascular-pathology-in-30217936","doi":"10.1212/wnl.0000000000006310","journal":"Neurology","n_participants":1175,"pmid":"30217936","source_url":"https://pubmed.ncbi.nlm.nih.gov/30217936/","study_design":"cross-sectional","title":"An MRI measure of degenerative and cerebrovascular pathology in Alzheimer disease","title_match":false,"year":2018},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/clinical-amyloid-imaging-27987555","doi":"10.1053/j.semnuclmed.2016.09.005","journal":"Seminars in nuclear medicine","n_participants":null,"pmid":"27987555","source_url":"https://pubmed.ncbi.nlm.nih.gov/27987555/","study_design":null,"title":"Clinical Amyloid Imaging","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/predictive-value-of-sup-18-sup-f-florbetapir-and-sup-18-sup-f-fdg-pet-31628215","doi":"10.2967/jnumed.119.230797","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":159,"pmid":"31628215","source_url":"https://pubmed.ncbi.nlm.nih.gov/31628215/","study_design":null,"title":"Predictive Value of 18F-Florbetapir and 18F-FDG PET for Conversion from Mild Cognitive Impairment to Alzheimer Dementia","title_match":true,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/visual-versus-fully-automated-analyses-of-18f-fdg-and-amyloid-pet-for-26585056","doi":"10.2967/jnumed.115.163717","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":null,"pmid":"26585056","source_url":"https://pubmed.ncbi.nlm.nih.gov/26585056/","study_design":null,"title":"Visual Versus Fully Automated Analyses of 18F-FDG and Amyloid PET for Prediction of Dementia Due to Alzheimer Disease in Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-prognosis-of-cognitive-decline-in-patients-with-35800899","doi":"10.1093/braincomms/fcac155","journal":"Brain communications","n_participants":60,"pmid":"35800899","source_url":"https://pubmed.ncbi.nlm.nih.gov/35800899/","study_design":"cohort study","title":"Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-derived-mitochondrial-dna-copy-number-is-associated-with-39444005","doi":"10.1186/s13195-024-01601-w","journal":"Alzheimer's research & therapy","n_participants":13799,"pmid":"39444005","source_url":"https://pubmed.ncbi.nlm.nih.gov/39444005/","study_design":null,"title":"Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites","title_match":false,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-in-mild-cognitive-impairment-patients-relationship-36880887","doi":"10.1111/ene.15762","journal":"European journal of neurology","n_participants":null,"pmid":"36880887","source_url":"https://pubmed.ncbi.nlm.nih.gov/36880887/","study_design":null,"title":"Blood biomarkers in mild cognitive impairment patients: Relationship between analytes and progression to Alzheimer disease dementia","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/neuronal-pentraxin-1-a-synaptic-derived-plasma-biomarker-in-alzheimer-29501530","doi":"10.1016/j.nbd.2018.02.014","journal":"Neurobiology of disease","n_participants":null,"pmid":"29501530","source_url":"https://pubmed.ncbi.nlm.nih.gov/29501530/","study_design":null,"title":"Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/spatial-navigation-and-its-association-with-biomarkers-and-future-36028328","doi":"10.1212/wnl.0000000000201106","journal":"Neurology","n_participants":176,"pmid":"36028328","source_url":"https://pubmed.ncbi.nlm.nih.gov/36028328/","study_design":"cohort study","title":"Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia","title_match":false,"year":2022},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-confirm-subjective-cognitive-decline-scd-as-a-40247130","doi":"10.1038/s41380-025-03021-0","journal":"Molecular psychiatry","n_participants":457,"pmid":"40247130","source_url":"https://pubmed.ncbi.nlm.nih.gov/40247130/","study_design":"longitudinal study","title":"Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer\u00b4s disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-levels-are-associated-with-cortical-31305887","doi":"10.1093/jnen/nlz054","journal":"Journal of neuropathology and experimental neurology","n_participants":149,"pmid":"31305887","source_url":"https://pubmed.ncbi.nlm.nih.gov/31305887/","study_design":null,"title":"Plasma Neurofilament Light Chain Levels Are Associated With Cortical Hypometabolism in Alzheimer Disease Signature Regions","title_match":false,"year":2019},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-longitudinal-atrophy-and-40063856","doi":"10.1212/wnl.0000000000213438","journal":"Neurology","n_participants":1240,"pmid":"40063856","source_url":"https://pubmed.ncbi.nlm.nih.gov/40063856/","study_design":"cohort study","title":"Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-and-risk-of-onset-of-mild-cognitive-impairment-39724536","doi":"10.1212/wnl.0000000000210225","journal":"Neurology","n_participants":271,"pmid":"39724536","source_url":"https://pubmed.ncbi.nlm.nih.gov/39724536/","study_design":"longitudinal study","title":"Blood-Based Biomarkers and Risk of Onset of Mild Cognitive Impairment Over the Short and Long Term","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-identifies-two-loci-influencing-plasma-29747637","doi":"10.1186/s12920-018-0364-8","journal":"BMC medical genomics","n_participants":179,"pmid":"29747637","source_url":"https://pubmed.ncbi.nlm.nih.gov/29747637/","study_design":"longitudinal study","title":"Genome-wide association study identifies two loci influencing plasma neurofilament light levels","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/added-value-of-cerebrospinal-fluid-multimarker-analysis-in-diagnosis-33236496","doi":"10.1111/ene.14658","journal":"European journal of neurology","n_participants":319,"pmid":"33236496","source_url":"https://pubmed.ncbi.nlm.nih.gov/33236496/","study_design":"longitudinal study","title":"Added value of cerebrospinal fluid multimarker analysis in diagnosis and progression of dementia","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/amyloid-pet-predicts-longitudinal-functional-and-cognitive-40145384","doi":"10.1002/alz.70075","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40145384","source_url":"https://pubmed.ncbi.nlm.nih.gov/40145384/","study_design":null,"title":"Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/molecular-imaging-of-alzheimer-disease-pathology-24503555","doi":"10.3174/ajnr.a3847","journal":"AJNR. American journal of neuroradiology","n_participants":null,"pmid":"24503555","source_url":"https://pubmed.ncbi.nlm.nih.gov/24503555/","study_design":"cohort study","title":"Molecular imaging of Alzheimer disease pathology","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/validation-of-the-alzheimer-disease-dementia-conversion-related-33408150","doi":"10.1212/wnl.0000000000011521","journal":"Neurology","n_participants":269,"pmid":"33408150","source_url":"https://pubmed.ncbi.nlm.nih.gov/33408150/","study_design":null,"title":"Validation of the Alzheimer Disease Dementia Conversion-Related Pattern as an ATN Biomarker of Neurodegeneration","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-biomarkers-may-aid-in-the-prognosis-of-mci-cases-31068481","doi":"10.1212/wnl.0000000000007609","journal":"Neurology","n_participants":757,"pmid":"31068481","source_url":"https://pubmed.ncbi.nlm.nih.gov/31068481/","study_design":null,"title":"Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal","title_match":false,"year":2019},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/longitudinal-blood-based-biomarkers-and-clinical-progression-in-41335440","doi":"10.1001/jamanetworkopen.2025.45862","journal":"JAMA network open","n_participants":298,"pmid":"41335440","source_url":"https://pubmed.ncbi.nlm.nih.gov/41335440/","study_design":"cohort study","title":"Longitudinal Blood-Based Biomarkers and Clinical Progression in Subjective Cognitive Decline","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/cognitive-decline-in-parkinson-disease-28257128","doi":"10.1038/nrneurol.2017.27","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"28257128","source_url":"https://pubmed.ncbi.nlm.nih.gov/28257128/","study_design":"longitudinal study","title":"Cognitive decline in Parkinson disease","title_match":false,"year":2017},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/sex-modifies-the-apoe-related-risk-of-developing-alzheimer-disease-24623176","doi":"10.1002/ana.24135","journal":"Annals of neurology","n_participants":5496,"pmid":"24623176","source_url":"https://pubmed.ncbi.nlm.nih.gov/24623176/","study_design":"case-control study","title":"Sex modifies the APOE-related risk of developing Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/increased-hippocampal-activation-in-mild-cognitive-impairment-16087905","doi":"10.1212/01.wnl.0000171450.97464.49","journal":"Neurology","n_participants":null,"pmid":"16087905","source_url":"https://pubmed.ncbi.nlm.nih.gov/16087905/","study_design":null,"title":"Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD","title_match":false,"year":2005},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/longitudinal-assessment-of-a-and-cognition-in-aging-and-alzheimer-21280088","doi":"10.1002/ana.22248","journal":"Annals of neurology","n_participants":206,"pmid":"21280088","source_url":"https://pubmed.ncbi.nlm.nih.gov/21280088/","study_design":null,"title":"Longitudinal assessment of A\u03b2 and cognition in aging and Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/synaptic-alterations-in-ca1-in-mild-alzheimer-disease-and-mild-17470753","doi":"10.1212/01.wnl.0000260698.46517.8f","journal":"Neurology","n_participants":null,"pmid":"17470753","source_url":"https://pubmed.ncbi.nlm.nih.gov/17470753/","study_design":null,"title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-and-sex-risk-factors-for-alzheimer-disease-28846757","doi":"10.1001/jamaneurol.2017.2188","journal":"JAMA neurology","n_participants":null,"pmid":"28846757","source_url":"https://pubmed.ncbi.nlm.nih.gov/28846757/","study_design":"case-control study","title":"Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis","title_match":false,"year":2017},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-and-mild-cognitive-impairment-19204158","doi":"10.1001/archneurol.2008.536","journal":"Archives of neurology","n_participants":482,"pmid":"19204158","source_url":"https://pubmed.ncbi.nlm.nih.gov/19204158/","study_design":null,"title":"Mediterranean diet and mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/comparing-predictors-of-conversion-and-decline-in-mild-cognitive-20592257","doi":"10.1212/wnl.0b013e3181e8e8b8","journal":"Neurology","n_participants":85,"pmid":"20592257","source_url":"https://pubmed.ncbi.nlm.nih.gov/20592257/","study_design":"longitudinal study","title":"Comparing predictors of conversion and decline in mild cognitive impairment","title_match":true,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/conversion-of-amyloid-positive-and-negative-mci-to-ad-over-3-years-an-19587325","doi":"10.1212/wnl.0b013e3181b23564","journal":"Neurology","n_participants":null,"pmid":"19587325","source_url":"https://pubmed.ncbi.nlm.nih.gov/19587325/","study_design":null,"title":"Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study","title_match":true,"year":2009},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/association-between-olfactory-dysfunction-and-amnestic-mild-cognitive-26569387","doi":"10.1001/jamaneurol.2015.2952","journal":"JAMA neurology","n_participants":1630,"pmid":"26569387","source_url":"https://pubmed.ncbi.nlm.nih.gov/26569387/","study_design":"longitudinal study","title":"Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia","title_match":false,"year":2016},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/mci-conversion-to-dementia-and-the-apoe-genotype-a-prediction-study-15623696","doi":"10.1212/01.wnl.0000147469.18313.3b","journal":"Neurology","n_participants":37,"pmid":"15623696","source_url":"https://pubmed.ncbi.nlm.nih.gov/15623696/","study_design":null,"title":"MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET","title_match":true,"year":2004},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/memory-impairment-but-not-cerebrovascular-disease-predicts-15277612","doi":"10.1212/01.wnl.0000130531.90205.ef","journal":"Neurology","n_participants":null,"pmid":"15277612","source_url":"https://pubmed.ncbi.nlm.nih.gov/15277612/","study_design":null,"title":"Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia","title_match":true,"year":2004},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/implementing-diagnostic-criteria-and-estimating-frequency-of-mild-16286549","doi":"10.1001/archneur.62.11.1739","journal":"Archives of neurology","n_participants":null,"pmid":"16286549","source_url":"https://pubmed.ncbi.nlm.nih.gov/16286549/","study_design":"cohort study","title":"Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community","title_match":false,"year":2005},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/amyloid-anxiety-and-cognitive-decline-in-preclinical-alzheimer-25629787","doi":"10.1001/jamapsychiatry.2014.2476","journal":"JAMA psychiatry","n_participants":333,"pmid":"25629787","source_url":"https://pubmed.ncbi.nlm.nih.gov/25629787/","study_design":"cohort study","title":"Amyloid-\u03b2, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/prediction-of-individual-clinical-outcome-in-mci-by-means-of-genetic-16204712","doi":null,"journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":22,"pmid":"16204712","source_url":"https://pubmed.ncbi.nlm.nih.gov/16204712/","study_design":"longitudinal study","title":"Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET","title_match":false,"year":2005},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/clinical-predictors-of-progression-to-alzheimer-disease-in-amnestic-17287448","doi":"10.1212/01.wnl.0000258542.58725.4c","journal":"Neurology","n_participants":539,"pmid":"17287448","source_url":"https://pubmed.ncbi.nlm.nih.gov/17287448/","study_design":null,"title":"Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment","title_match":true,"year":2007},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/conversion-to-dementia-from-mild-cognitive-disorder-the-cache-county-16864813","doi":"10.1212/01.wnl.0000224748.48011.84","journal":"Neurology","n_participants":120,"pmid":"16864813","source_url":"https://pubmed.ncbi.nlm.nih.gov/16864813/","study_design":null,"title":"Conversion to dementia from mild cognitive disorder: the Cache County Study","title_match":false,"year":2006},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/volumetric-mri-vs-clinical-predictors-of-alzheimer-disease-in-mild-18195264","doi":"10.1212/01.wnl.0000287091.57376.65","journal":"Neurology","n_participants":129,"pmid":"18195264","source_url":"https://pubmed.ncbi.nlm.nih.gov/18195264/","study_design":null,"title":"Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment","title_match":false,"year":2008},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-with-suspected-nonamyloid-pathology-snap-25568301","doi":"10.1212/wnl.0000000000001209","journal":"Neurology","n_participants":201,"pmid":"25568301","source_url":"https://pubmed.ncbi.nlm.nih.gov/25568301/","study_design":null,"title":"Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression","title_match":true,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-risk-of-incident-mild-cognitive-impairment-and-progression-to-28413413","doi":"10.1159/000452486","journal":"Dementia and geriatric cognitive disorders extra","n_participants":null,"pmid":"28413413","source_url":"https://pubmed.ncbi.nlm.nih.gov/28413413/","study_design":null,"title":"The Risk of Incident Mild Cognitive Impairment and Progression to Dementia Considering Mild Cognitive Impairment Subtypes","title_match":true,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/prediction-of-alzheimer-disease-in-subjects-with-amnestic-and-23446677","doi":"10.1212/wnl.0b013e318288690c","journal":"Neurology","n_participants":231,"pmid":"23446677","source_url":"https://pubmed.ncbi.nlm.nih.gov/23446677/","study_design":null,"title":"Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/temporal-dynamics-of-amyloid-accumulation-in-aging-and-alzheimer-33408147","doi":"10.1212/wnl.0000000000011524","journal":"Neurology","n_participants":475,"pmid":"33408147","source_url":"https://pubmed.ncbi.nlm.nih.gov/33408147/","study_design":null,"title":"Temporal Dynamics of \u03b2-Amyloid Accumulation in Aging and Alzheimer Disease","title_match":false,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/injury-markers-predict-time-to-dementia-in-subjects-with-mci-and-23019259","doi":"10.1212/wnl.0b013e3182704056","journal":"Neurology","n_participants":110,"pmid":"23019259","source_url":"https://pubmed.ncbi.nlm.nih.gov/23019259/","study_design":"cohort study","title":"Injury markers predict time to dementia in subjects with MCI and amyloid pathology","title_match":false,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-risk-for-alzheimer-disease-is-distinct-from-genetic-risk-for-31199530","doi":"10.1002/ana.25530","journal":"Annals of neurology","n_participants":null,"pmid":"31199530","source_url":"https://pubmed.ncbi.nlm.nih.gov/31199530/","study_design":null,"title":"Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/multicenter-assessment-of-csf-phosphorylated-tau-for-the-prediction-18071141","doi":"10.1212/01.wnl.0000286944.22262.ff","journal":"Neurology","n_participants":43,"pmid":"18071141","source_url":"https://pubmed.ncbi.nlm.nih.gov/18071141/","study_design":null,"title":"Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI","title_match":true,"year":2007},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cognitive-frailty-predementia-syndrome-and-vascular-risk-factors-16023766","doi":"10.1016/j.neurobiolaging.2005.05.008","journal":"Neurobiology of aging","n_participants":null,"pmid":"16023766","source_url":"https://pubmed.ncbi.nlm.nih.gov/16023766/","study_design":null,"title":"Cognitive frailty: Predementia syndrome and vascular risk factors","title_match":false,"year":2006},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/validation-of-olfactory-deficit-as-a-biomarker-of-alzheimer-disease-28243501","doi":"10.1212/cpj.0000000000000293","journal":"Neurology. Clinical practice","n_participants":96,"pmid":"28243501","source_url":"https://pubmed.ncbi.nlm.nih.gov/28243501/","study_design":"cross-sectional","title":"Validation of olfactory deficit as a biomarker of Alzheimer disease","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/disturbed-sleep-patterns-in-elders-with-mild-cognitive-impairment-the-22211488","doi":"10.2174/156720512800107609","journal":"Current Alzheimer research","n_participants":null,"pmid":"22211488","source_url":"https://pubmed.ncbi.nlm.nih.gov/22211488/","study_design":null,"title":"Disturbed sleep patterns in elders with mild cognitive impairment: the role of memory decline and ApoE \u03b54 genotype","title_match":false,"year":2012},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/revealing-individual-neuroanatomical-heterogeneity-in-alzheimer-37127353","doi":"10.1212/wnl.0000000000207298","journal":"Neurology","n_participants":33072,"pmid":"37127353","source_url":"https://pubmed.ncbi.nlm.nih.gov/37127353/","study_design":null,"title":"Revealing Individual Neuroanatomical Heterogeneity in Alzheimer Disease Using Neuroanatomical Normative Modeling","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/late-onset-alzheimer-s-risk-variants-in-memory-decline-incident-mild-25189118","doi":"10.1016/j.neurobiolaging.2014.07.042","journal":"Neurobiology of aging","n_participants":null,"pmid":"25189118","source_url":"https://pubmed.ncbi.nlm.nih.gov/25189118/","study_design":null,"title":"Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/predictive-utility-of-apolipoprotein-e-genotype-for-alzheimer-disease-15956169","doi":"10.1001/archneur.62.6.975","journal":"Archives of neurology","n_participants":57,"pmid":"15956169","source_url":"https://pubmed.ncbi.nlm.nih.gov/15956169/","study_design":"longitudinal study","title":"Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/correlating-cerebral-hypometabolism-with-future-memory-decline-in-18779428","doi":"10.1001/archneurol.2008.1","journal":"Archives of neurology","n_participants":null,"pmid":"18779428","source_url":"https://pubmed.ncbi.nlm.nih.gov/18779428/","study_design":"longitudinal study","title":"Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment","title_match":true,"year":2008},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/predictors-of-conversion-to-dementia-of-probable-alzheimer-type-in-16611017","doi":"10.2174/156720506776383103","journal":"Current Alzheimer research","n_participants":null,"pmid":"16611017","source_url":"https://pubmed.ncbi.nlm.nih.gov/16611017/","study_design":null,"title":"Predictors of conversion to dementia of probable Alzheimer type in patients with mild cognitive impairment","title_match":true,"year":2006},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/value-of-serum-nonceruloplasmin-copper-for-prediction-of-mild-24623259","doi":"10.1002/ana.24136","journal":"Annals of neurology","n_participants":42,"pmid":"24623259","source_url":"https://pubmed.ncbi.nlm.nih.gov/24623259/","study_design":"meta-analysis","title":"Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease","title_match":true,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/effect-of-cognitive-reserve-markers-on-alzheimer-pathologic-23552443","doi":"10.1097/wad.0b013e3182900b2b","journal":"Alzheimer disease and associated disorders","n_participants":819,"pmid":"23552443","source_url":"https://pubmed.ncbi.nlm.nih.gov/23552443/","study_design":"longitudinal study","title":"Effect of cognitive reserve markers on Alzheimer pathologic progression","title_match":false,"year":2013},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/regional-cerebral-perfusion-in-patients-with-alzheimer-s-disease-and-22828738","doi":"10.1007/s00234-012-1077-x","journal":"Neuroradiology","n_participants":null,"pmid":"22828738","source_url":"https://pubmed.ncbi.nlm.nih.gov/22828738/","study_design":null,"title":"Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele","title_match":false,"year":2013},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/donanemab-in-early-symptomatic-alzheimer-disease-the-trailblazer-alz-37459141","doi":"10.1001/jama.2023.13239","journal":"JAMA","n_participants":860,"pmid":"37459141","source_url":"https://pubmed.ncbi.nlm.nih.gov/37459141/","study_design":"clinical trial","title":"Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial","title_match":false,"year":2023},{"alzhub_score":82,"alzhub_url":"https://alzhub.org/study/ginkgo-biloba-for-prevention-of-dementia-a-randomized-controlled-trial-19017911","doi":"10.1001/jama.2008.683","journal":"JAMA","n_participants":2587,"pmid":"19017911","source_url":"https://pubmed.ncbi.nlm.nih.gov/19017911/","study_design":null,"title":"Ginkgo biloba for prevention of dementia: a randomized controlled trial","title_match":false,"year":2008},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/cholinesterase-inhibitors-in-mild-cognitive-impairment-a-systematic-18044984","doi":"10.1371/journal.pmed.0040338","journal":"PLoS medicine","n_participants":null,"pmid":"18044984","source_url":"https://pubmed.ncbi.nlm.nih.gov/18044984/","study_design":null,"title":"Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials","title_match":false,"year":2007},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/efficacy-and-safety-of-lanabecestat-for-treatment-of-early-and-mild-31764959","doi":"10.1001/jamaneurol.2019.3988","journal":"JAMA neurology","n_participants":6871,"pmid":"31764959","source_url":"https://pubmed.ncbi.nlm.nih.gov/31764959/","study_design":"clinical trial","title":"Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials","title_match":false,"year":2020},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/brain-atrophy-in-cognitively-impaired-elderly-the-importance-of-long-25877495","doi":"10.3945/ajcn.114.103283","journal":"The American journal of clinical nutrition","n_participants":83,"pmid":"25877495","source_url":"https://pubmed.ncbi.nlm.nih.gov/25877495/","study_design":null,"title":"Brain atrophy in cognitively impaired elderly: the importance of long-chain \u03c9-3 fatty acids and B vitamin status in a randomized controlled trial","title_match":false,"year":2015},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/low-dose-ladostigil-for-mild-cognitive-impairment-a-phase-2-placebo-31492718","doi":"10.1212/wnl.0000000000008239","journal":"Neurology","n_participants":107,"pmid":"31492718","source_url":"https://pubmed.ncbi.nlm.nih.gov/31492718/","study_design":"clinical trial","title":"Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial","title_match":false,"year":2019},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/a-randomized-double-blind-placebo-controlled-trial-of-triflusal-in-18317243","doi":"10.1097/wad.0b013e3181611024","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"18317243","source_url":"https://pubmed.ncbi.nlm.nih.gov/18317243/","study_design":null,"title":"A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study","title_match":false,"year":2008},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/slowing-cognitive-decline-in-major-depressive-disorder-and-mild-39476073","doi":"10.1001/jamapsychiatry.2024.3241","journal":"JAMA psychiatry","n_participants":null,"pmid":"39476073","source_url":"https://pubmed.ncbi.nlm.nih.gov/39476073/","study_design":null,"title":"Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/using-historical-data-to-facilitate-clinical-prevention-trials-in-33962665","doi":"10.1186/s13195-021-00832-5","journal":"Alzheimer's research & therapy","n_participants":395,"pmid":"33962665","source_url":"https://pubmed.ncbi.nlm.nih.gov/33962665/","study_design":"cohort study","title":"Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-effect-of-transcranial-alternating-current-stimulation-with-35475789","doi":"10.2196/37282","journal":"JMIR research protocols","n_participants":75,"pmid":"35475789","source_url":"https://pubmed.ncbi.nlm.nih.gov/35475789/","study_design":null,"title":"The Effect of Transcranial Alternating Current Stimulation With Cognitive Training on Executive Brain Function in Individuals With Dementia: Protocol for a Crossover Randomized Controlled Trial","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/five-year-outcomes-after-ivig-for-mild-cognitive-impairment-due-to-34362303","doi":"10.1186/s12868-021-00651-2","journal":"BMC neuroscience","n_participants":null,"pmid":"34362303","source_url":"https://pubmed.ncbi.nlm.nih.gov/34362303/","study_design":null,"title":"Five-year outcomes after IVIG for mild cognitive impairment due to alzheimer disease","title_match":false,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/nutritional-interventions-for-the-prevention-of-cognitive-decline-in-38416536","doi":"10.2196/47196","journal":"JMIR research protocols","n_participants":51,"pmid":"38416536","source_url":"https://pubmed.ncbi.nlm.nih.gov/38416536/","study_design":"systematic review","title":"Nutritional Interventions for the Prevention of Cognitive Decline in Patients With Mild Cognitive Impairment and Alzheimer Disease: Protocol for a Network Meta-Analysis of Randomized Controlled Trials","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-16631882","doi":"10.1016/s0140-6736(06)68542-5","journal":"Lancet (London, England)","n_participants":null,"pmid":"16631882","source_url":"https://pubmed.ncbi.nlm.nih.gov/16631882/","study_design":null,"title":"Mild cognitive impairment","title_match":false,"year":2006},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/clinical-epidemiology-of-alzheimer-s-disease-assessing-sex-and-gender-24470773","doi":"10.2147/clep.s37929","journal":"Clinical epidemiology","n_participants":null,"pmid":"24470773","source_url":"https://pubmed.ncbi.nlm.nih.gov/24470773/","study_design":null,"title":"Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences","title_match":false,"year":2014},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-as-early-manifestations-of-emergent-26096665","doi":"10.1016/j.jalz.2015.05.017","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26096665","source_url":"https://pubmed.ncbi.nlm.nih.gov/26096665/","study_design":null,"title":"Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/outcome-over-seven-years-of-healthy-adults-with-and-without-20129317","doi":"10.1016/j.jalz.2009.10.002","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":213,"pmid":"20129317","source_url":"https://pubmed.ncbi.nlm.nih.gov/20129317/","study_design":null,"title":"Outcome over seven years of healthy adults with and without subjective cognitive impairment","title_match":false,"year":2010},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-mediterranean-diet-with-mild-cognitive-impairment-and-24164735","doi":"10.3233/jad-130830","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"24164735","source_url":"https://pubmed.ncbi.nlm.nih.gov/24164735/","study_design":"systematic review","title":"Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis","title_match":false,"year":2014},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/modifiable-predictors-of-dementia-in-mild-cognitive-impairment-a-25698435","doi":"10.1176/appi.ajp.2014.14070878","journal":"The American journal of psychiatry","n_participants":null,"pmid":"25698435","source_url":"https://pubmed.ncbi.nlm.nih.gov/25698435/","study_design":"meta-analysis","title":"Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-and-its-management-in-older-people-25914527","doi":"10.2147/cia.s73922","journal":"Clinical interventions in aging","n_participants":null,"pmid":"25914527","source_url":"https://pubmed.ncbi.nlm.nih.gov/25914527/","study_design":null,"title":"Mild cognitive impairment and its management in older people","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/does-vigorous-exercise-have-a-neuroprotective-effect-in-parkinson-21768599","doi":"10.1212/wnl.0b013e318225ab66","journal":"Neurology","n_participants":null,"pmid":"21768599","source_url":"https://pubmed.ncbi.nlm.nih.gov/21768599/","study_design":null,"title":"Does vigorous exercise have a neuroprotective effect in Parkinson disease?","title_match":false,"year":2011},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/different-cognitive-frailty-models-and-health-and-cognitive-related-29562543","doi":"10.3233/jad-170963","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29562543","source_url":"https://pubmed.ncbi.nlm.nih.gov/29562543/","study_design":"cross-sectional","title":"Different Cognitive Frailty Models and Health- and Cognitive-related Outcomes in Older Age: From Epidemiology to Prevention","title_match":false,"year":2018},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/worldwide-prevalence-of-mild-cognitive-impairment-among-community-35977150","doi":"10.1093/ageing/afac173","journal":"Age and ageing","n_participants":242804,"pmid":"35977150","source_url":"https://pubmed.ncbi.nlm.nih.gov/35977150/","study_design":"systematic review","title":"Worldwide prevalence of mild cognitive impairment among community dwellers aged 50\u00a0years and older: a meta-analysis and systematic review of epidemiology studies","title_match":false,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/exergaming-and-older-adult-cognition-a-cluster-randomized-clinical-22261206","doi":"10.1016/j.amepre.2011.10.016","journal":"American journal of preventive medicine","n_participants":null,"pmid":"22261206","source_url":"https://pubmed.ncbi.nlm.nih.gov/22261206/","study_design":null,"title":"Exergaming and older adult cognition: a cluster randomized clinical trial","title_match":false,"year":2012},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/modifiable-factors-that-alter-the-size-of-the-hippocampus-with-ageing-22410582","doi":"10.1038/nrneurol.2012.27","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"22410582","source_url":"https://pubmed.ncbi.nlm.nih.gov/22410582/","study_design":null,"title":"Modifiable factors that alter the size of the hippocampus with ageing","title_match":false,"year":2012},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-and-progression-to-dementia-in-people-with-30182156","doi":"10.1007/s00127-018-1581-3","journal":"Social psychiatry and psychiatric epidemiology","n_participants":15,"pmid":"30182156","source_url":"https://pubmed.ncbi.nlm.nih.gov/30182156/","study_design":"meta-analysis","title":"Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis","title_match":true,"year":2018},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/effects-of-n-3-fatty-acids-epa-v-dha-on-depressive-symptoms-quality-21929835","doi":"10.1017/s0007114511004788","journal":"The British journal of nutrition","n_participants":null,"pmid":"21929835","source_url":"https://pubmed.ncbi.nlm.nih.gov/21929835/","study_design":"randomized controlled trial","title":"Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial","title_match":false,"year":2012},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/depressive-symptoms-increase-the-risk-of-progression-to-dementia-in-26680599","doi":"10.1002/gps.4406","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"26680599","source_url":"https://pubmed.ncbi.nlm.nih.gov/26680599/","study_design":"meta-analysis","title":"Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis","title_match":true,"year":2016},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/prevalence-and-outcomes-of-amyloid-positivity-among-persons-without-29710225","doi":"10.1001/jamaneurol.2018.0629","journal":"JAMA neurology","n_participants":3894,"pmid":"29710225","source_url":"https://pubmed.ncbi.nlm.nih.gov/29710225/","study_design":null,"title":"Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting","title_match":false,"year":2018},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/subjective-cognitive-decline-level-of-risk-for-future-dementia-and-34748154","doi":"10.1007/s11065-021-09522-3","journal":"Neuropsychology review","n_participants":null,"pmid":"34748154","source_url":"https://pubmed.ncbi.nlm.nih.gov/34748154/","study_design":"meta-analysis","title":"Subjective Cognitive Decline: Level of Risk for Future Dementia and Mild Cognitive Impairment, a Meta-Analysis of Longitudinal Studies","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/predicting-alzheimer-disease-with-amyloid-imaging-results-from-the-24448836","doi":"10.1002/ana.24040","journal":"Annals of neurology","n_participants":87,"pmid":"24448836","source_url":"https://pubmed.ncbi.nlm.nih.gov/24448836/","study_design":null,"title":"Predicting Alzheimer disease with \u03b2-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing","title_match":false,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/mild-behavioral-impairment-and-risk-of-dementia-a-prospective-cohort-19323967","doi":"10.4088/jcp.08m04181","journal":"The Journal of clinical psychiatry","n_participants":null,"pmid":"19323967","source_url":"https://pubmed.ncbi.nlm.nih.gov/19323967/","study_design":null,"title":"Mild behavioral impairment and risk of dementia: a prospective cohort study of 358 patients","title_match":false,"year":2009},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/diet-and-alzheimer-s-disease-risk-factors-or-prevention-the-current-21539488","doi":"10.1586/ern.11.56","journal":"Expert review of neurotherapeutics","n_participants":null,"pmid":"21539488","source_url":"https://pubmed.ncbi.nlm.nih.gov/21539488/","study_design":null,"title":"Diet and Alzheimer's disease risk factors or prevention: the current evidence","title_match":false,"year":2011},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/a-1-year-randomized-controlled-trial-comparing-mind-body-exercise-tai-22579072","doi":"10.1016/j.jamda.2012.03.008","journal":"Journal of the American Medical Directors Association","n_participants":389,"pmid":"22579072","source_url":"https://pubmed.ncbi.nlm.nih.gov/22579072/","study_design":"randomized controlled trial","title":"A 1-year randomized controlled trial comparing mind body exercise (Tai Chi) with stretching and toning exercise on cognitive function in older Chinese adults at risk of cognitive decline","title_match":false,"year":2012},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-and-dementia-the-importance-of-modifiable-22163250","doi":"10.3238/arztebl.2011.0743","journal":"Deutsches Arzteblatt international","n_participants":null,"pmid":"22163250","source_url":"https://pubmed.ncbi.nlm.nih.gov/22163250/","study_design":null,"title":"Mild cognitive impairment and dementia: the importance of modifiable risk factors","title_match":false,"year":2011},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/factors-predicting-reversion-from-mild-cognitive-impairment-to-normal-23544083","doi":"10.1371/journal.pone.0059649","journal":"PloS one","n_participants":223,"pmid":"23544083","source_url":"https://pubmed.ncbi.nlm.nih.gov/23544083/","study_design":"longitudinal study","title":"Factors predicting reversion from mild cognitive impairment to normal cognitive functioning: a population-based study","title_match":false,"year":2013},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/a-deep-learning-model-for-early-prediction-of-alzheimer-s-disease-31201098","doi":"10.1016/j.jalz.2019.02.007","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2146,"pmid":"31201098","source_url":"https://pubmed.ncbi.nlm.nih.gov/31201098/","study_design":null,"title":"A deep learning model for early prediction of Alzheimer's disease dementia based on hippocampal magnetic resonance imaging data","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-and-cognitive-function-in-older-adults-19834324","doi":"10.1097/mco.0b013e3283331fe4","journal":"Current opinion in clinical nutrition and metabolic care","n_participants":null,"pmid":"19834324","source_url":"https://pubmed.ncbi.nlm.nih.gov/19834324/","study_design":null,"title":"Mediterranean diet and cognitive function in older adults","title_match":false,"year":2010},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/coffee-tea-and-caffeine-consumption-and-prevention-of-late-life-25732217","doi":"10.1007/s12603-014-0563-8","journal":"The journal of nutrition, health & aging","n_participants":null,"pmid":"25732217","source_url":"https://pubmed.ncbi.nlm.nih.gov/25732217/","study_design":"case-control study","title":"Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review","title_match":false,"year":2015},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-new-dsm-5-diagnosis-of-mild-neurocognitive-disorder-and-its-24914889","doi":"10.1080/13607863.2014.920303","journal":"Aging & mental health","n_participants":null,"pmid":"24914889","source_url":"https://pubmed.ncbi.nlm.nih.gov/24914889/","study_design":null,"title":"The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment","title_match":false,"year":2015},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/efficacy-of-cognitive-rehabilitation-therapies-for-mild-cognitive-23471631","doi":"10.1007/s11065-013-9230-9","journal":"Neuropsychology review","n_participants":null,"pmid":"23471631","source_url":"https://pubmed.ncbi.nlm.nih.gov/23471631/","study_design":null,"title":"Efficacy of cognitive rehabilitation therapies for mild cognitive impairment (MCI) in older adults: working toward a theoretical model and evidence-based interventions","title_match":false,"year":2013},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/the-vascular-hypothesis-of-alzheimer-s-disease-a-key-to-preclinical-29614675","doi":"10.3233/jad-180004","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29614675","source_url":"https://pubmed.ncbi.nlm.nih.gov/29614675/","study_design":null,"title":"The Vascular Hypothesis of Alzheimer's Disease: A Key to Preclinical Prediction of Dementia Using Neuroimaging","title_match":false,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/the-montreal-cognitive-assessment-moca-a-brief-screening-tool-for-15817019","doi":"10.1111/j.1532-5415.2005.53221.x","journal":"Journal of the American Geriatrics Society","n_participants":93,"pmid":"15817019","source_url":"https://pubmed.ncbi.nlm.nih.gov/15817019/","study_design":null,"title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-as-a-diagnostic-entity-15324362","doi":"10.1111/j.1365-2796.2004.01388.x","journal":"Journal of internal medicine","n_participants":null,"pmid":"15324362","source_url":"https://pubmed.ncbi.nlm.nih.gov/15324362/","study_design":null,"title":"Mild cognitive impairment as a diagnostic entity","title_match":false,"year":2004},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/toward-defining-the-preclinical-stages-of-alzheimer-s-disease-21514248","doi":"10.1016/j.jalz.2011.03.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"21514248","source_url":"https://pubmed.ncbi.nlm.nih.gov/21514248/","study_design":"longitudinal study","title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/current-concepts-in-mild-cognitive-impairment-11735772","doi":"10.1001/archneur.58.12.1985","journal":"Archives of neurology","n_participants":null,"pmid":"11735772","source_url":"https://pubmed.ncbi.nlm.nih.gov/11735772/","study_design":null,"title":"Current concepts in mild cognitive impairment","title_match":false,"year":2001},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/the-clinical-use-of-structural-mri-in-alzheimer-disease-20139996","doi":"10.1038/nrneurol.2009.215","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"20139996","source_url":"https://pubmed.ncbi.nlm.nih.gov/20139996/","study_design":null,"title":"The clinical use of structural MRI in Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/association-between-csf-biomarkers-and-incipient-alzheimer-s-disease-16488378","doi":"10.1016/s1474-4422(06)70355-6","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16488378","source_url":"https://pubmed.ncbi.nlm.nih.gov/16488378/","study_design":null,"title":"Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study","title_match":false,"year":2006},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-in-alzheimer-s-disease-relationship-to-other-32123385","doi":"10.1038/s41591-020-0755-1","journal":"Nature medicine","n_participants":589,"pmid":"32123385","source_url":"https://pubmed.ncbi.nlm.nih.gov/32123385/","study_design":null,"title":"Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia","title_match":false,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/csf-markers-for-incipient-alzheimer-s-disease-14505582","doi":"10.1016/s1474-4422(03)00530-1","journal":"The Lancet. Neurology","n_participants":null,"pmid":"14505582","source_url":"https://pubmed.ncbi.nlm.nih.gov/14505582/","study_design":null,"title":"CSF markers for incipient Alzheimer's disease","title_match":false,"year":2003},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/tau-positron-emission-tomographic-imaging-in-aging-and-early-26505746","doi":"10.1002/ana.24546","journal":"Annals of neurology","n_participants":null,"pmid":"26505746","source_url":"https://pubmed.ncbi.nlm.nih.gov/26505746/","study_design":null,"title":"Tau positron emission tomographic imaging in aging and early Alzheimer disease","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-phospholipids-identify-antecedent-memory-impairment-in-older-24608097","doi":"10.1038/nm.3466","journal":"Nature medicine","n_participants":null,"pmid":"24608097","source_url":"https://pubmed.ncbi.nlm.nih.gov/24608097/","study_design":null,"title":"Plasma phospholipids identify antecedent memory impairment in older adults","title_match":false,"year":2014},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-and-incipient-alzheimer-disease-in-patients-with-mild-19622817","doi":"10.1001/jama.2009.1064","journal":"JAMA","n_participants":750,"pmid":"19622817","source_url":"https://pubmed.ncbi.nlm.nih.gov/19622817/","study_design":"cohort study","title":"CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/dementia-and-cognitive-impairment-epidemiology-diagnosis-and-treatment-25037289","doi":"10.1016/j.cger.2014.04.001","journal":"Clinics in geriatric medicine","n_participants":null,"pmid":"25037289","source_url":"https://pubmed.ncbi.nlm.nih.gov/25037289/","study_design":null,"title":"Dementia and cognitive impairment: epidemiology, diagnosis, and treatment","title_match":false,"year":2014},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/mini-mental-state-examination-mmse-for-the-detection-of-alzheimer-s-25740785","doi":"10.1002/14651858.cd010783.pub2","journal":"The Cochrane database of systematic reviews","n_participants":null,"pmid":"25740785","source_url":"https://pubmed.ncbi.nlm.nih.gov/25740785/","study_design":"longitudinal study","title":"Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)","title_match":false,"year":2015},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/classification-and-epidemiology-of-mci-24094295","doi":"10.1016/j.cger.2013.07.003","journal":"Clinics in geriatric medicine","n_participants":null,"pmid":"24094295","source_url":"https://pubmed.ncbi.nlm.nih.gov/24094295/","study_design":null,"title":"Classification and epidemiology of MCI","title_match":false,"year":2013},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-status-as-a-predictor-of-the-development-of-7646655","doi":"10.1001/jama.1995.03520400044042","journal":"JAMA","n_participants":66,"pmid":"7646655","source_url":"https://pubmed.ncbi.nlm.nih.gov/7646655/","study_design":"longitudinal study","title":"Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals","title_match":false,"year":1995},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/aging-memory-and-mild-cognitive-impairment-9447429","doi":"10.1017/s1041610297004717","journal":"International psychogeriatrics","n_participants":null,"pmid":"9447429","source_url":"https://pubmed.ncbi.nlm.nih.gov/9447429/","study_design":null,"title":"Aging, memory, and mild cognitive impairment","title_match":false,"year":1997},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-10-plasma-phospho-tau-assays-in-prodromal-36087307","doi":"10.1093/brain/awac333","journal":"Brain : a journal of neurology","n_participants":135,"pmid":"36087307","source_url":"https://pubmed.ncbi.nlm.nih.gov/36087307/","study_design":null,"title":"Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-epidemiology-and-clinical-progression-35286590","doi":"10.1007/s40120-022-00338-8","journal":"Neurology and therapy","n_participants":null,"pmid":"35286590","source_url":"https://pubmed.ncbi.nlm.nih.gov/35286590/","study_design":null,"title":"Alzheimer's Disease: Epidemiology and Clinical Progression","title_match":false,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/frequency-and-course-of-mild-cognitive-impairment-in-a-multiethnic-18300306","doi":"10.1002/ana.21326","journal":"Annals of neurology","n_participants":2364,"pmid":"18300306","source_url":"https://pubmed.ncbi.nlm.nih.gov/18300306/","study_design":null,"title":"Frequency and course of mild cognitive impairment in a multiethnic community","title_match":false,"year":2008},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/comparison-of-multiple-tau-pet-measures-as-biomarkers-in-aging-and-28587897","doi":"10.1016/j.neuroimage.2017.05.058","journal":"NeuroImage","n_participants":null,"pmid":"28587897","source_url":"https://pubmed.ncbi.nlm.nih.gov/28587897/","study_design":null,"title":"Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disorder-risk-in-idiopathic-rem-sleep-behavior-24587002","doi":"10.1371/journal.pone.0089741","journal":"PloS one","n_participants":174,"pmid":"24587002","source_url":"https://pubmed.ncbi.nlm.nih.gov/24587002/","study_design":null,"title":"Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients","title_match":false,"year":2014},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/prevalence-of-depression-in-patients-with-mild-cognitive-impairment-a-27893026","doi":"10.1001/jamapsychiatry.2016.3162","journal":"JAMA psychiatry","n_participants":892,"pmid":"27893026","source_url":"https://pubmed.ncbi.nlm.nih.gov/27893026/","study_design":null,"title":"Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis","title_match":false,"year":2017},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-long-term-course-of-four-clinical-subtypes-17190940","doi":"10.1212/01.wnl.0000249117.23318.e1","journal":"Neurology","n_participants":null,"pmid":"17190940","source_url":"https://pubmed.ncbi.nlm.nih.gov/17190940/","study_design":"longitudinal study","title":"Mild cognitive impairment: long-term course of four clinical subtypes","title_match":false,"year":2006},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-in-patients-with-parkinson-s-disease-diagnosis-22814541","doi":"10.1016/s1474-4422(12)70152-7","journal":"The Lancet. Neurology","n_participants":null,"pmid":"22814541","source_url":"https://pubmed.ncbi.nlm.nih.gov/22814541/","study_design":null,"title":"Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment","title_match":false,"year":2012},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-has-similar-alterations-as-alzheimer-s-31434623","doi":"10.1016/j.jalz.2019.07.002","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31434623","source_url":"https://pubmed.ncbi.nlm.nih.gov/31434623/","study_design":null,"title":"Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/baseline-mri-predictors-of-conversion-from-mci-to-probable-ad-in-the-19689234","doi":"10.2174/156720509788929273","journal":"Current Alzheimer research","n_participants":339,"pmid":"19689234","source_url":"https://pubmed.ncbi.nlm.nih.gov/19689234/","study_design":"longitudinal study","title":"Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort","title_match":true,"year":2009},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/higher-risk-of-progression-to-dementia-in-mild-cognitive-impairment-24353333","doi":"10.1212/wnl.0000000000000055","journal":"Neurology","n_participants":534,"pmid":"24353333","source_url":"https://pubmed.ncbi.nlm.nih.gov/24353333/","study_design":null,"title":"Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal","title_match":true,"year":2014},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/fdg-pet-changes-in-brain-glucose-metabolism-from-normal-cognition-to-19142633","doi":"10.1007/s00259-008-1039-z","journal":"European journal of nuclear medicine and molecular imaging","n_participants":null,"pmid":"19142633","source_url":"https://pubmed.ncbi.nlm.nih.gov/19142633/","study_design":"longitudinal study","title":"FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/age-specific-incidence-rates-of-alzheimer-s-disease-the-baltimore-10851365","doi":"10.1212/wnl.54.11.2072","journal":"Neurology","n_participants":1236,"pmid":"10851365","source_url":"https://pubmed.ncbi.nlm.nih.gov/10851365/","study_design":"longitudinal study","title":"Age-specific incidence rates of Alzheimer's disease: the Baltimore Longitudinal Study of Aging","title_match":false,"year":2000},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/amnestic-syndrome-of-the-medial-temporal-type-identifies-prodromal-ad-17984454","doi":"10.1212/01.wnl.0000279336.36610.f7","journal":"Neurology","n_participants":251,"pmid":"17984454","source_url":"https://pubmed.ncbi.nlm.nih.gov/17984454/","study_design":null,"title":"Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study","title_match":false,"year":2007},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-cerebrospinal-fluid-biomarkers-in-the-diagnosis-24795085","doi":"10.1016/j.jalz.2014.02.004","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"24795085","source_url":"https://pubmed.ncbi.nlm.nih.gov/24795085/","study_design":null,"title":"Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/mini-mental-state-examination-mmse-for-the-early-detection-of-34313331","doi":"10.1002/14651858.cd010783.pub3","journal":"The Cochrane database of systematic reviews","n_participants":null,"pmid":"34313331","source_url":"https://pubmed.ncbi.nlm.nih.gov/34313331/","study_design":"longitudinal study","title":"Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)","title_match":false,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-protein-biomarkers-for-alzheimer-s-disease-15717022","doi":"10.1602/neurorx.1.2.213","journal":"NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics","n_participants":null,"pmid":"15717022","source_url":"https://pubmed.ncbi.nlm.nih.gov/15717022/","study_design":null,"title":"Cerebrospinal fluid protein biomarkers for Alzheimer's disease","title_match":false,"year":2004},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/the-impact-of-mild-cognitive-impairment-on-gait-and-balance-a-27172932","doi":"10.1159/000445831","journal":"Gerontology","n_participants":null,"pmid":"27172932","source_url":"https://pubmed.ncbi.nlm.nih.gov/27172932/","study_design":"meta-analysis","title":"The Impact of Mild Cognitive Impairment on Gait and Balance: A Systematic Review and Meta-Analysis of Studies Using Instrumented Assessment","title_match":false,"year":2017},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-and-prediction-of-clinical-progression-of-33106600","doi":"10.1038/s41380-020-00923-z","journal":"Molecular psychiatry","n_participants":1000,"pmid":"33106600","source_url":"https://pubmed.ncbi.nlm.nih.gov/33106600/","study_design":"longitudinal study","title":"Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-28689566","doi":"10.1016/j.cger.2017.02.005","journal":"Clinics in geriatric medicine","n_participants":null,"pmid":"28689566","source_url":"https://pubmed.ncbi.nlm.nih.gov/28689566/","study_design":null,"title":"Mild Cognitive Impairment","title_match":false,"year":2017},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/a-randomized-double-blind-study-of-rofecoxib-in-patients-with-mild-15742005","doi":"10.1038/sj.npp.1300690","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":725,"pmid":"15742005","source_url":"https://pubmed.ncbi.nlm.nih.gov/15742005/","study_design":null,"title":"A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/comparative-accuracies-of-two-common-screening-instruments-for-23260866","doi":"10.1016/j.jalz.2012.10.001","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"23260866","source_url":"https://pubmed.ncbi.nlm.nih.gov/23260866/","study_design":null,"title":"Comparative accuracies of two common screening instruments for\u00a0classification of Alzheimer's disease, mild cognitive impairment, and\u00a0healthy aging","title_match":false,"year":2013},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/neuropathologic-outcome-of-mild-cognitive-impairment-following-16682537","doi":"10.1001/archneur.63.5.674","journal":"Archives of neurology","n_participants":null,"pmid":"16682537","source_url":"https://pubmed.ncbi.nlm.nih.gov/16682537/","study_design":null,"title":"Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia","title_match":true,"year":2006},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/prevalence-and-prognosis-of-alzheimer-s-disease-at-the-mild-cognitive-25693589","doi":"10.1093/brain/awv029","journal":"Brain : a journal of neurology","n_participants":1607,"pmid":"25693589","source_url":"https://pubmed.ncbi.nlm.nih.gov/25693589/","study_design":null,"title":"Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage","title_match":false,"year":2015},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/olfactory-bulb-involvement-in-neurodegenerative-diseases-24554308","doi":"10.1007/s00401-014-1261-7","journal":"Acta neuropathologica","n_participants":536,"pmid":"24554308","source_url":"https://pubmed.ncbi.nlm.nih.gov/24554308/","study_design":null,"title":"Olfactory bulb involvement in neurodegenerative diseases","title_match":false,"year":2014},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/comparison-of-different-mri-brain-atrophy-rate-measures-with-clinical-14981176","doi":"10.1212/01.wnl.0000110315.26026.ef","journal":"Neurology","n_participants":55,"pmid":"14981176","source_url":"https://pubmed.ncbi.nlm.nih.gov/14981176/","study_design":null,"title":"Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD","title_match":false,"year":2004},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/hippocampal-and-entorhinal-atrophy-in-mild-cognitive-impairment-17353470","doi":"10.1212/01.wnl.0000256697.20968.d7","journal":"Neurology","n_participants":139,"pmid":"17353470","source_url":"https://pubmed.ncbi.nlm.nih.gov/17353470/","study_design":null,"title":"Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease","title_match":false,"year":2007},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/brain-atrophy-rates-predict-subsequent-clinical-conversion-in-normal-16247049","doi":"10.1212/01.wnl.0000180958.22678.91","journal":"Neurology","n_participants":72,"pmid":"16247049","source_url":"https://pubmed.ncbi.nlm.nih.gov/16247049/","study_design":null,"title":"Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI","title_match":true,"year":2005},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/random-forest-algorithm-for-the-classification-of-neuroimaging-data-29056906","doi":"10.3389/fnagi.2017.00329","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"29056906","source_url":"https://pubmed.ncbi.nlm.nih.gov/29056906/","study_design":"systematic review","title":"Random Forest Algorithm for the Classification of Neuroimaging Data in Alzheimer's Disease: A Systematic Review","title_match":false,"year":2017},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-of-neuroinflammation-and-cerebrovascular-dysfunction-30054439","doi":"10.1212/wnl.0000000000006082","journal":"Neurology","n_participants":508,"pmid":"30054439","source_url":"https://pubmed.ncbi.nlm.nih.gov/30054439/","study_design":"longitudinal study","title":"CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease","title_match":false,"year":2018},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/hippocampal-atrophy-rates-in-alzheimer-disease-added-value-over-whole-19289740","doi":"10.1212/01.wnl.0000344568.09360.31","journal":"Neurology","n_participants":64,"pmid":"19289740","source_url":"https://pubmed.ncbi.nlm.nih.gov/19289740/","study_design":null,"title":"Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures","title_match":false,"year":2009},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/mri-patterns-of-atrophy-associated-with-progression-to-ad-in-amnestic-17898323","doi":"10.1212/01.wnl.0000280575.77437.a2","journal":"Neurology","n_participants":null,"pmid":"17898323","source_url":"https://pubmed.ncbi.nlm.nih.gov/17898323/","study_design":null,"title":"MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment","title_match":true,"year":2008},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/mri-and-csf-biomarkers-in-normal-mci-and-ad-subjects-predicting-19636049","doi":"10.1212/wnl.0b013e3181af79fb","journal":"Neurology","n_participants":399,"pmid":"19636049","source_url":"https://pubmed.ncbi.nlm.nih.gov/19636049/","study_design":null,"title":"MRI and CSF biomarkers in normal, MCI, and AD subjects: predicting future clinical change","title_match":false,"year":2009},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/the-cortical-signature-of-prodromal-ad-regional-thinning-predicts-19109536","doi":"10.1212/01.wnl.0000340981.97664.2f","journal":"Neurology","n_participants":49,"pmid":"19109536","source_url":"https://pubmed.ncbi.nlm.nih.gov/19109536/","study_design":"longitudinal study","title":"The cortical signature of prodromal AD: regional thinning predicts mild AD dementia","title_match":false,"year":2009},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/default-mode-network-connectivity-in-stable-vs-progressive-mild-21228297","doi":"10.1212/wnl.0b013e31820af94e","journal":"Neurology","n_participants":68,"pmid":"21228297","source_url":"https://pubmed.ncbi.nlm.nih.gov/21228297/","study_design":"cross-sectional","title":"Default mode network connectivity in stable vs progressive mild cognitive impairment","title_match":false,"year":2011},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/regional-rates-of-neocortical-atrophy-from-normal-aging-to-early-19667321","doi":"10.1212/wnl.0b013e3181b16431","journal":"Neurology","n_participants":472,"pmid":"19667321","source_url":"https://pubmed.ncbi.nlm.nih.gov/19667321/","study_design":"longitudinal study","title":"Regional rates of neocortical atrophy from normal aging to early Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/tau-pet-in-alzheimer-disease-and-mild-cognitive-impairment-27358341","doi":"10.1212/wnl.0000000000002892","journal":"Neurology","n_participants":20,"pmid":"27358341","source_url":"https://pubmed.ncbi.nlm.nih.gov/27358341/","study_design":null,"title":"Tau PET in Alzheimer disease and mild cognitive impairment","title_match":false,"year":2016},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/asl-perfusion-mri-predicts-cognitive-decline-and-conversion-from-mci-20220321","doi":"10.1097/wad.0b013e3181b4f736","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"20220321","source_url":"https://pubmed.ncbi.nlm.nih.gov/20220321/","study_design":"longitudinal study","title":"ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia","title_match":true,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/short-term-clinical-outcomes-for-stages-of-nia-aa-preclinical-22551733","doi":"10.1212/wnl.0b013e3182563bbe","journal":"Neurology","n_participants":null,"pmid":"22551733","source_url":"https://pubmed.ncbi.nlm.nih.gov/22551733/","study_design":null,"title":"Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/dwi-predicts-future-progression-to-alzheimer-disease-in-amnestic-mild-15753434","doi":"10.1212/01.wnl.0000153076.46126.e9","journal":"Neurology","n_participants":null,"pmid":"15753434","source_url":"https://pubmed.ncbi.nlm.nih.gov/15753434/","study_design":null,"title":"DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment","title_match":true,"year":2005},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/magnetic-resonance-imaging-white-matter-hyperintensities-and-brain-18195145","doi":"10.1001/archneurol.2007.23","journal":"Archives of neurology","n_participants":67,"pmid":"18195145","source_url":"https://pubmed.ncbi.nlm.nih.gov/18195145/","study_design":"cohort study","title":"Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia","title_match":false,"year":2008},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/imaging-markers-for-alzheimer-disease-which-vs-how-23897875","doi":"10.1212/wnl.0b013e31829d86e8","journal":"Neurology","n_participants":null,"pmid":"23897875","source_url":"https://pubmed.ncbi.nlm.nih.gov/23897875/","study_design":null,"title":"Imaging markers for Alzheimer disease: which vs how","title_match":false,"year":2013},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/predicting-mci-outcome-with-clinically-available-mri-and-csf-21998317","doi":"10.1212/wnl.0b013e3182343314","journal":"Neurology","n_participants":null,"pmid":"21998317","source_url":"https://pubmed.ncbi.nlm.nih.gov/21998317/","study_design":null,"title":"Predicting MCI outcome with clinically available MRI and CSF biomarkers","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/flair-and-diffusion-mri-signals-are-independent-predictors-of-white-22700749","doi":"10.3174/ajnr.a3146","journal":"AJNR. American journal of neuroradiology","n_participants":null,"pmid":"22700749","source_url":"https://pubmed.ncbi.nlm.nih.gov/22700749/","study_design":"longitudinal study","title":"FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities","title_match":false,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/coevolution-of-white-matter-hyperintensities-and-cognition-in-the-22815562","doi":"10.1212/wnl.0b013e3182617136","journal":"Neurology","n_participants":150,"pmid":"22815562","source_url":"https://pubmed.ncbi.nlm.nih.gov/22815562/","study_design":"longitudinal study","title":"Coevolution of white matter hyperintensities and cognition in the elderly","title_match":false,"year":2012},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/atrophy-rates-accelerate-in-amnestic-mild-cognitive-impairment-18032747","doi":"10.1212/01.wnl.0000281688.77598.35","journal":"Neurology","n_participants":46,"pmid":"18032747","source_url":"https://pubmed.ncbi.nlm.nih.gov/18032747/","study_design":null,"title":"Atrophy rates accelerate in amnestic mild cognitive impairment","title_match":false,"year":2008},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cerebral-atrophy-in-mild-cognitive-impairment-and-alzheimer-disease-23303849","doi":"10.1212/wnl.0b013e318281ccd3","journal":"Neurology","n_participants":null,"pmid":"23303849","source_url":"https://pubmed.ncbi.nlm.nih.gov/23303849/","study_design":null,"title":"Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration","title_match":false,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/vascular-burden-and-alzheimer-disease-pathologic-progression-22972646","doi":"10.1212/wnl.0b013e31826c1b9d","journal":"Neurology","n_participants":null,"pmid":"22972646","source_url":"https://pubmed.ncbi.nlm.nih.gov/22972646/","study_design":"longitudinal study","title":"Vascular burden and Alzheimer disease pathologic progression","title_match":false,"year":2012},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-contribution-of-voxel-based-morphometry-in-staging-patients-with-16894107","doi":"10.1212/01.wnl.0000228243.56665.c2","journal":"Neurology","n_participants":22,"pmid":"16894107","source_url":"https://pubmed.ncbi.nlm.nih.gov/16894107/","study_design":null,"title":"The contribution of voxel-based morphometry in staging patients with mild cognitive impairment","title_match":false,"year":2006},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-levels-and-the-risk-of-ad-in-normal-subjects-in-the-18401021","doi":"10.1212/01.wnl.0000306696.82017.66","journal":"Neurology","n_participants":55,"pmid":"18401021","source_url":"https://pubmed.ncbi.nlm.nih.gov/18401021/","study_design":"cross-sectional","title":"Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/conversion-of-amnestic-mild-cognitive-impairment-to-dementia-of-17562522","doi":"10.1002/gps.1816","journal":"International journal of geriatric psychiatry","n_participants":40,"pmid":"17562522","source_url":"https://pubmed.ncbi.nlm.nih.gov/17562522/","study_design":null,"title":"Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration","title_match":true,"year":2007},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/anxiety-symptoms-in-amnestic-mild-cognitive-impairment-are-associated-25500120","doi":"10.1016/j.jagp.2014.10.005","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":376,"pmid":"25500120","source_url":"https://pubmed.ncbi.nlm.nih.gov/25500120/","study_design":null,"title":"Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease","title_match":true,"year":2015},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/association-of-elevated-amyloid-and-tau-positron-emission-tomography-35907254","doi":"10.1001/jamaneurol.2022.2379","journal":"JAMA neurology","n_participants":580,"pmid":"35907254","source_url":"https://pubmed.ncbi.nlm.nih.gov/35907254/","study_design":"cohort study","title":"Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/resting-metabolic-connectivity-in-prodromal-alzheimer-s-disease-a-22365486","doi":"10.1016/j.neurobiolaging.2012.01.005","journal":"Neurobiology of aging","n_participants":36,"pmid":"22365486","source_url":"https://pubmed.ncbi.nlm.nih.gov/22365486/","study_design":null,"title":"Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project","title_match":false,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/entorhinal-cortex-thickness-predicts-cognitive-decline-in-alzheimer-s-23047370","doi":"10.3233/jad-2012-121408","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"23047370","source_url":"https://pubmed.ncbi.nlm.nih.gov/23047370/","study_design":"longitudinal study","title":"Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/trajectory-of-white-matter-hyperintensity-burden-preceding-mild-22843262","doi":"10.1212/wnl.0b013e3182661f2b","journal":"Neurology","n_participants":134,"pmid":"22843262","source_url":"https://pubmed.ncbi.nlm.nih.gov/22843262/","study_design":"longitudinal study","title":"Trajectory of white matter hyperintensity burden preceding mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/myeloid-microvesicles-in-cerebrospinal-fluid-are-associated-with-25087695","doi":"10.1002/ana.24235","journal":"Annals of neurology","n_participants":null,"pmid":"25087695","source_url":"https://pubmed.ncbi.nlm.nih.gov/25087695/","study_design":null,"title":"Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/addneuromed-and-adni-similar-patterns-of-alzheimer-s-atrophy-and-21763442","doi":"10.1016/j.neuroimage.2011.06.065","journal":"NeuroImage","n_participants":1074,"pmid":"21763442","source_url":"https://pubmed.ncbi.nlm.nih.gov/21763442/","study_design":null,"title":"AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America","title_match":false,"year":2011},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/microstructural-white-matter-changes-in-cognitively-normal-22843270","doi":"10.1212/wnl.0b013e3182661f4d","journal":"Neurology","n_participants":193,"pmid":"22843270","source_url":"https://pubmed.ncbi.nlm.nih.gov/22843270/","study_design":null,"title":"Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/reduced-fdg-pet-brain-metabolism-and-executive-function-predict-24286024","doi":"10.1016/j.nicl.2013.10.018","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"24286024","source_url":"https://pubmed.ncbi.nlm.nih.gov/24286024/","study_design":null,"title":"Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/oxidatively-modified-mitochondria-relevant-brain-proteins-in-subjects-19777328","doi":"10.1007/s10863-009-9241-7","journal":"Journal of bioenergetics and biomembranes","n_participants":null,"pmid":"19777328","source_url":"https://pubmed.ncbi.nlm.nih.gov/19777328/","study_design":null,"title":"Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/prediction-and-classification-of-alzheimer-disease-based-on-28264071","doi":"10.1371/journal.pone.0173372","journal":"PloS one","n_participants":null,"pmid":"28264071","source_url":"https://pubmed.ncbi.nlm.nih.gov/28264071/","study_design":null,"title":"Prediction and classification of Alzheimer disease based on quantification of MRI deformation","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/periventricular-white-matter-hyperintensities-increase-the-likelihood-18825439","doi":"10.1007/s00415-008-0874-y","journal":"Journal of neurology","n_participants":null,"pmid":"18825439","source_url":"https://pubmed.ncbi.nlm.nih.gov/18825439/","study_design":null,"title":"Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia","title_match":true,"year":2008},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/progressive-tau-accumulation-in-alzheimer-disease-2-year-follow-up-30926651","doi":"10.2967/jnumed.118.221697","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":107,"pmid":"30926651","source_url":"https://pubmed.ncbi.nlm.nih.gov/30926651/","study_design":"cross-sectional","title":"Progressive Tau Accumulation in Alzheimer Disease: 2-Year Follow-up Study","title_match":false,"year":2019},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/interpreting-biomarker-results-in-individual-patients-with-mild-29049480","doi":"10.1001/jamaneurol.2017.2712","journal":"JAMA neurology","n_participants":525,"pmid":"29049480","source_url":"https://pubmed.ncbi.nlm.nih.gov/29049480/","study_design":"longitudinal study","title":"Interpreting Biomarker Results in Individual Patients With Mild Cognitive Impairment in the Alzheimer's Biomarkers in Daily Practice (ABIDE) Project","title_match":false,"year":2017},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/mapping-brain-morphological-and-functional-conversion-patterns-in-19662411","doi":"10.1007/s00259-009-1218-6","journal":"European journal of nuclear medicine and molecular imaging","n_participants":20,"pmid":"19662411","source_url":"https://pubmed.ncbi.nlm.nih.gov/19662411/","study_design":null,"title":"Mapping brain morphological and functional conversion patterns in amnestic MCI: a voxel-based MRI and FDG-PET study","title_match":true,"year":2010},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/mri-measures-of-temporoparietal-regions-show-differential-rates-of-18672473","doi":"10.1212/01.wnl.0000320055.57329.34","journal":"Neurology","n_participants":66,"pmid":"18672473","source_url":"https://pubmed.ncbi.nlm.nih.gov/18672473/","study_design":null,"title":"MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD","title_match":false,"year":2008},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/sustainable-method-for-alzheimer-dementia-prediction-in-mild-30014515","doi":"10.1002/ana.25289","journal":"Annals of neurology","n_participants":97,"pmid":"30014515","source_url":"https://pubmed.ncbi.nlm.nih.gov/30014515/","study_design":null,"title":"Sustainable method for Alzheimer dementia prediction in mild cognitive impairment: Electroencephalographic connectivity and graph theory combined with apolipoprotein E","title_match":false,"year":2018},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-brain-magnetic-resonance-imaging-signs-with-cognitive-31074810","doi":"10.1001/jamanetworkopen.2019.3359","journal":"JAMA network open","n_participants":1553,"pmid":"31074810","source_url":"https://pubmed.ncbi.nlm.nih.gov/31074810/","study_design":"cohort study","title":"Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment","title_match":false,"year":2019},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/white-matter-hyperintensities-and-csf-alzheimer-disease-biomarkers-in-31888969","doi":"10.1212/wnl.0000000000008864","journal":"Neurology","n_participants":274,"pmid":"31888969","source_url":"https://pubmed.ncbi.nlm.nih.gov/31888969/","study_design":"longitudinal study","title":"White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/hippocampal-volumes-proton-magnetic-resonance-spectroscopy-19064749","doi":"10.1001/archneur.65.12.1621","journal":"Archives of neurology","n_participants":32,"pmid":"19064749","source_url":"https://pubmed.ncbi.nlm.nih.gov/19064749/","study_design":"case-control study","title":"Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes","title_match":false,"year":2008},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/tau-positron-emission-tomography-for-predicting-dementia-in-38857029","doi":"10.1001/jamaneurol.2024.1612","journal":"JAMA neurology","n_participants":110,"pmid":"38857029","source_url":"https://pubmed.ncbi.nlm.nih.gov/38857029/","study_design":"cohort study","title":"Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/vascular-subcortical-hyperintensities-predict-conversion-to-vascular-18436882","doi":"10.1161/strokeaha.107.505206","journal":"Stroke","n_participants":170,"pmid":"18436882","source_url":"https://pubmed.ncbi.nlm.nih.gov/18436882/","study_design":null,"title":"Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients","title_match":true,"year":2008},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/grey-matter-changes-in-cognitively-impaired-parkinson-s-disease-24465612","doi":"10.1371/journal.pone.0085595","journal":"PloS one","n_participants":null,"pmid":"24465612","source_url":"https://pubmed.ncbi.nlm.nih.gov/24465612/","study_design":null,"title":"Grey matter changes in cognitively impaired Parkinson's disease patients","title_match":false,"year":2014},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/baseline-csf-p-tau-levels-independently-predict-progression-of-19770469","doi":"10.1212/wnl.0b013e3181b879ac","journal":"Neurology","n_participants":31,"pmid":"19770469","source_url":"https://pubmed.ncbi.nlm.nih.gov/19770469/","study_design":null,"title":"Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/comparing-3t-and-1-5t-mri-for-mapping-hippocampal-atrophy-in-the-25614473","doi":"10.3174/ajnr.a4228","journal":"AJNR. American journal of neuroradiology","n_participants":166,"pmid":"25614473","source_url":"https://pubmed.ncbi.nlm.nih.gov/25614473/","study_design":null,"title":"Comparing 3T and 1.5T MRI for mapping hippocampal atrophy in the Alzheimer's Disease Neuroimaging Initiative","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-bayer-activities-of-daily-living-scale-b-adl-9718231","doi":"10.1159/000051195","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"9718231","source_url":"https://pubmed.ncbi.nlm.nih.gov/9718231/","study_design":null,"title":"The Bayer Activities of Daily Living Scale (B-ADL)","title_match":false,"year":1998},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-in-parkinson-disease-impact-on-quality-of-life-23172765","doi":"10.1177/0891988712464823","journal":"Journal of geriatric psychiatry and neurology","n_participants":54,"pmid":"23172765","source_url":"https://pubmed.ncbi.nlm.nih.gov/23172765/","study_design":null,"title":"Cognitive impairment in Parkinson disease: impact on quality of life, disability, and caregiver burden","title_match":false,"year":2012},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/in-vivo-radioligand-binding-to-translocator-protein-correlates-with-23775979","doi":"10.1093/brain/awt145","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"23775979","source_url":"https://pubmed.ncbi.nlm.nih.gov/23775979/","study_design":"longitudinal study","title":"In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/risk-factors-for-the-progression-of-mild-cognitive-impairment-to-24094301","doi":"10.1016/j.cger.2013.07.009","journal":"Clinics in geriatric medicine","n_participants":null,"pmid":"24094301","source_url":"https://pubmed.ncbi.nlm.nih.gov/24094301/","study_design":null,"title":"Risk factors for the progression of mild cognitive impairment to dementia","title_match":true,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/subjective-memory-decline-predicts-greater-rates-of-clinical-26852195","doi":"10.1016/j.jalz.2015.12.013","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26852195","source_url":"https://pubmed.ncbi.nlm.nih.gov/26852195/","study_design":null,"title":"Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/amyloid-is-linked-to-cognitive-decline-in-patients-with-parkinson-23243071","doi":"10.1212/wnl.0b013e31827b1a07","journal":"Neurology","n_participants":46,"pmid":"23243071","source_url":"https://pubmed.ncbi.nlm.nih.gov/23243071/","study_design":"cohort study","title":"Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia","title_match":false,"year":2013},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/vitamin-d-status-and-rates-of-cognitive-decline-in-a-multiethnic-26366714","doi":"10.1001/jamaneurol.2015.2115","journal":"JAMA neurology","n_participants":382,"pmid":"26366714","source_url":"https://pubmed.ncbi.nlm.nih.gov/26366714/","study_design":"cohort study","title":"Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/use-of-an-alzheimer-s-disease-polygenic-risk-score-to-identify-mild-29487403","doi":"10.1038/s41380-018-0030-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"29487403","source_url":"https://pubmed.ncbi.nlm.nih.gov/29487403/","study_design":null,"title":"Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s","title_match":false,"year":2019},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/rate-of-progression-of-mild-cognitive-impairment-to-dementia-meta-19236314","doi":"10.1111/j.1600-0447.2008.01326.x","journal":"Acta psychiatrica Scandinavica","n_participants":null,"pmid":"19236314","source_url":"https://pubmed.ncbi.nlm.nih.gov/19236314/","study_design":"meta-analysis","title":"Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies","title_match":true,"year":2009},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/risk-of-dementia-and-mild-cognitive-impairment-in-older-people-with-25219393","doi":"10.1111/acps.12336","journal":"Acta psychiatrica Scandinavica","n_participants":15009,"pmid":"25219393","source_url":"https://pubmed.ncbi.nlm.nih.gov/25219393/","study_design":"meta-analysis","title":"Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis","title_match":false,"year":2014},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/risk-and-predictors-of-dementia-and-parkinsonism-in-idiopathic-rem-30789229","doi":"10.1093/brain/awz030","journal":"Brain : a journal of neurology","n_participants":1280,"pmid":"30789229","source_url":"https://pubmed.ncbi.nlm.nih.gov/30789229/","study_design":null,"title":"Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study","title_match":false,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-27042901","doi":"10.1212/con.0000000000000313","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"27042901","source_url":"https://pubmed.ncbi.nlm.nih.gov/27042901/","study_design":null,"title":"Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/prediction-of-dementia-by-subjective-memory-impairment-effects-of-20368517","doi":"10.1001/archgenpsychiatry.2010.30","journal":"Archives of general psychiatry","n_participants":2415,"pmid":"20368517","source_url":"https://pubmed.ncbi.nlm.nih.gov/20368517/","study_design":"cohort study","title":"Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment","title_match":false,"year":2010},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/classification-criteria-for-mild-cognitive-impairment-a-population-11148233","doi":"10.1212/wnl.56.1.37","journal":"Neurology","n_participants":null,"pmid":"11148233","source_url":"https://pubmed.ncbi.nlm.nih.gov/11148233/","study_design":"longitudinal study","title":"Classification criteria for mild cognitive impairment: a population-based validation study","title_match":false,"year":2001},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-amnestic-type-an-epidemiologic-study-15249620","doi":"10.1212/01.wnl.0000132523.27540.81","journal":"Neurology","n_participants":1248,"pmid":"15249620","source_url":"https://pubmed.ncbi.nlm.nih.gov/15249620/","study_design":null,"title":"Mild cognitive impairment, amnestic type: an epidemiologic study","title_match":false,"year":2004},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-disease-neuroimaging-initiative-positron-emission-20451870","doi":"10.1016/j.jalz.2010.03.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":100,"pmid":"20451870","source_url":"https://pubmed.ncbi.nlm.nih.gov/20451870/","study_design":"longitudinal study","title":"The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core","title_match":false,"year":2010},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/late-life-depression-mild-cognitive-impairment-and-dementia-possible-20104067","doi":"10.1097/jgp.0b013e3181b0fa13","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"20104067","source_url":"https://pubmed.ncbi.nlm.nih.gov/20104067/","study_design":null,"title":"Late-life depression, mild cognitive impairment, and dementia: possible continuum?","title_match":false,"year":2010},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/prevalence-and-prognostic-value-of-csf-markers-of-alzheimer-s-disease-19523877","doi":"10.1016/s1474-4422(09)70139-5","journal":"The Lancet. Neurology","n_participants":null,"pmid":"19523877","source_url":"https://pubmed.ncbi.nlm.nih.gov/19523877/","study_design":"cohort study","title":"Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study","title_match":false,"year":2009},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/incidence-and-outcome-of-mild-cognitive-impairment-in-a-population-12451203","doi":"10.1212/01.wnl.0000034176.07159.f8","journal":"Neurology","n_participants":1265,"pmid":"12451203","source_url":"https://pubmed.ncbi.nlm.nih.gov/12451203/","study_design":null,"title":"Incidence and outcome of mild cognitive impairment in a population-based prospective cohort","title_match":false,"year":2002},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/in-vivo-staging-of-regional-amyloid-deposition-29046362","doi":"10.1212/wnl.0000000000004643","journal":"Neurology","n_participants":667,"pmid":"29046362","source_url":"https://pubmed.ncbi.nlm.nih.gov/29046362/","study_design":"cross-sectional","title":"In vivo staging of regional amyloid deposition","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/state-of-the-science-on-mild-cognitive-impairment-mci-30651152","doi":"10.1017/s1092852918001347","journal":"CNS spectrums","n_participants":null,"pmid":"30651152","source_url":"https://pubmed.ncbi.nlm.nih.gov/30651152/","study_design":null,"title":"State of the science on mild cognitive impairment (MCI)","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-prevalence-prognosis-aetiology-and-treatment-12849297","doi":"10.1016/s1474-4422(03)00262-x","journal":"The Lancet. Neurology","n_participants":null,"pmid":"12849297","source_url":"https://pubmed.ncbi.nlm.nih.gov/12849297/","study_design":null,"title":"Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment","title_match":false,"year":2003},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/conversion-of-mild-cognitive-impairment-to-alzheimer-disease-16682538","doi":"10.1001/archneur.63.5.693","journal":"Archives of neurology","n_participants":null,"pmid":"16682538","source_url":"https://pubmed.ncbi.nlm.nih.gov/16682538/","study_design":"cohort study","title":"Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps","title_match":true,"year":2006},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/vascular-risk-factors-incidence-of-mci-and-rates-of-progression-to-15557506","doi":"10.1212/01.wnl.0000144281.38555.e3","journal":"Neurology","n_participants":2963,"pmid":"15557506","source_url":"https://pubmed.ncbi.nlm.nih.gov/15557506/","study_design":"longitudinal study","title":"Vascular risk factors, incidence of MCI, and rates of progression to dementia","title_match":true,"year":2004},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/parkinson-risk-in-idiopathic-rem-sleep-behavior-disorder-preparing-25681454","doi":"10.1212/wnl.0000000000001364","journal":"Neurology","n_participants":89,"pmid":"25681454","source_url":"https://pubmed.ncbi.nlm.nih.gov/25681454/","study_design":"prospective cohort","title":"Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/sleep-disordered-breathing-advances-cognitive-decline-in-the-elderly-25878183","doi":"10.1212/wnl.0000000000001566","journal":"Neurology","n_participants":null,"pmid":"25878183","source_url":"https://pubmed.ncbi.nlm.nih.gov/25878183/","study_design":null,"title":"Sleep-disordered breathing advances cognitive decline in the elderly","title_match":false,"year":2015},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/conversion-from-subtypes-of-mild-cognitive-impairment-to-alzheimer-17242334","doi":"10.1212/01.wnl.0000252358.03285.9d","journal":"Neurology","n_participants":1505,"pmid":"17242334","source_url":"https://pubmed.ncbi.nlm.nih.gov/17242334/","study_design":null,"title":"Conversion from subtypes of mild cognitive impairment to Alzheimer dementia","title_match":true,"year":2007},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/rate-of-conversion-from-prodromal-alzheimer-s-disease-to-alzheimer-s-24174927","doi":"10.1159/000354370","journal":"Dementia and geriatric cognitive disorders extra","n_participants":null,"pmid":"24174927","source_url":"https://pubmed.ncbi.nlm.nih.gov/24174927/","study_design":"systematic review","title":"Rate of conversion from prodromal Alzheimer's disease to Alzheimer's dementia: a systematic review of the literature","title_match":false,"year":2013},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/connected-speech-as-a-marker-of-disease-progression-in-autopsy-proven-24142144","doi":"10.1093/brain/awt269","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"24142144","source_url":"https://pubmed.ncbi.nlm.nih.gov/24142144/","study_design":"cohort study","title":"Connected speech as a marker of disease progression in autopsy-proven Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/data-mining-methods-in-the-prediction-of-dementia-a-real-data-21849043","doi":"10.1186/1756-0500-4-299","journal":"BMC research notes","n_participants":null,"pmid":"21849043","source_url":"https://pubmed.ncbi.nlm.nih.gov/21849043/","study_design":null,"title":"Data mining methods in the prediction of Dementia: A real-data comparison of the accuracy, sensitivity and specificity of linear discriminant analysis, logistic regression, neural networks, support vector machines, classification trees and random forests","title_match":false,"year":2011},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/machine-learning-methods-for-predicting-progression-from-mild-34583745","doi":"10.1186/s13195-021-00900-w","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"34583745","source_url":"https://pubmed.ncbi.nlm.nih.gov/34583745/","study_design":"systematic review","title":"Machine learning methods for predicting progression from mild cognitive impairment to Alzheimer's disease dementia: a systematic review","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/rey-s-auditory-verbal-learning-test-scores-can-be-predicted-from-28116234","doi":"10.1016/j.nicl.2016.12.011","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"28116234","source_url":"https://pubmed.ncbi.nlm.nih.gov/28116234/","study_design":null,"title":"Rey's Auditory Verbal Learning Test scores can be predicted from whole brain MRI in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/machine-learning-of-neuroimaging-for-assisted-diagnosis-of-cognitive-30364671","doi":"10.1016/j.dadm.2018.07.004","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"30364671","source_url":"https://pubmed.ncbi.nlm.nih.gov/30364671/","study_design":null,"title":"Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review","title_match":false,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/automated-hippocampal-shape-analysis-predicts-the-onset-of-dementia-21272654","doi":"10.1016/j.neuroimage.2011.01.050","journal":"NeuroImage","n_participants":null,"pmid":"21272654","source_url":"https://pubmed.ncbi.nlm.nih.gov/21272654/","study_design":"longitudinal study","title":"Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment","title_match":false,"year":2011},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/a-cerebrospinal-fluid-synaptic-protein-biomarker-for-prediction-of-40164724","doi":"10.1038/s41591-025-03565-2","journal":"Nature medicine","n_participants":3397,"pmid":"40164724","source_url":"https://pubmed.ncbi.nlm.nih.gov/40164724/","study_design":"case-control study","title":"A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-biosignature-and-brain-pathology-related-to-persistent-25092249","doi":"10.1038/mp.2014.76","journal":"Molecular psychiatry","n_participants":null,"pmid":"25092249","source_url":"https://pubmed.ncbi.nlm.nih.gov/25092249/","study_design":null,"title":"Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/use-of-multimodality-imaging-and-artificial-intelligence-for-29352978","doi":"10.1016/j.trsl.2018.01.001","journal":"Translational research : the journal of laboratory and clinical medicine","n_participants":null,"pmid":"29352978","source_url":"https://pubmed.ncbi.nlm.nih.gov/29352978/","study_design":"longitudinal study","title":"Use of multimodality imaging and artificial intelligence for diagnosis and prognosis of early stages of Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/long-term-cognitive-prognosis-of-profoundly-deaf-older-adults-after-30091185","doi":"10.1111/jgs.15445","journal":"Journal of the American Geriatrics Society","n_participants":70,"pmid":"30091185","source_url":"https://pubmed.ncbi.nlm.nih.gov/30091185/","study_design":"longitudinal study","title":"Long-Term Cognitive Prognosis of Profoundly Deaf Older Adults After Hearing Rehabilitation Using Cochlear Implants","title_match":false,"year":2018},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/predicting-the-progression-of-mild-cognitive-impairment-using-machine-33091740","doi":"10.1016/j.media.2020.101848","journal":"Medical image analysis","n_participants":172,"pmid":"33091740","source_url":"https://pubmed.ncbi.nlm.nih.gov/33091740/","study_design":"systematic review","title":"Predicting the progression of mild cognitive impairment using machine learning: A systematic, quantitative and critical review","title_match":true,"year":2021},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/artificial-intelligence-in-brain-mri-analysis-of-alzheimer-s-disease-35358720","doi":"10.1016/j.arr.2022.101614","journal":"Ageing research reviews","n_participants":null,"pmid":"35358720","source_url":"https://pubmed.ncbi.nlm.nih.gov/35358720/","study_design":"systematic review","title":"Artificial intelligence in brain MRI analysis of Alzheimer's disease over the past 12 years: A systematic review","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/performance-of-machine-learning-algorithms-for-predicting-progression-34913981","doi":"10.1001/jamanetworkopen.2021.36553","journal":"JAMA network open","n_participants":307,"pmid":"34913981","source_url":"https://pubmed.ncbi.nlm.nih.gov/34913981/","study_design":"prospective cohort","title":"Performance of Machine Learning Algorithms for Predicting Progression to Dementia in Memory Clinic Patients","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/use-of-speech-analyses-within-a-mobile-application-for-the-assessment-28847279","doi":"10.2174/1567205014666170829111942","journal":"Current Alzheimer research","n_participants":165,"pmid":"28847279","source_url":"https://pubmed.ncbi.nlm.nih.gov/28847279/","study_design":null,"title":"Use of Speech Analyses within a Mobile Application for the Assessment of Cognitive Impairment in Elderly People","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/using-machine-learning-to-quantify-structural-mri-neurodegeneration-32614505","doi":"10.1002/hbm.25115","journal":"Human brain mapping","n_participants":null,"pmid":"32614505","source_url":"https://pubmed.ncbi.nlm.nih.gov/32614505/","study_design":null,"title":"Using machine learning to quantify structural MRI neurodegeneration patterns of Alzheimer's disease into dementia score: Independent validation on 8,834 images from ADNI, AIBL, OASIS, and MIRIAD databases","title_match":false,"year":2020},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/a-novel-ensemble-based-machine-learning-algorithm-to-predict-the-31379711","doi":"10.3389/fneur.2019.00756","journal":"Frontiers in neurology","n_participants":null,"pmid":"31379711","source_url":"https://pubmed.ncbi.nlm.nih.gov/31379711/","study_design":null,"title":"A Novel Ensemble-Based Machine Learning Algorithm to Predict the Conversion From Mild Cognitive Impairment to Alzheimer's Disease Using Socio-Demographic Characteristics, Clinical Information, and Neuropsychological Measures","title_match":true,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/predicting-short-term-mci-to-ad-progression-using-imaging-csf-genetic-30783207","doi":"10.1038/s41598-019-38793-3","journal":"Scientific reports","n_participants":null,"pmid":"30783207","source_url":"https://pubmed.ncbi.nlm.nih.gov/30783207/","study_design":null,"title":"Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics","title_match":true,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/identifying-incipient-dementia-individuals-using-machine-learning-and-28756942","doi":"10.1016/j.neurobiolaging.2017.06.027","journal":"Neurobiology of aging","n_participants":null,"pmid":"28756942","source_url":"https://pubmed.ncbi.nlm.nih.gov/28756942/","study_design":null,"title":"Identifying incipient dementia individuals using machine learning and amyloid imaging","title_match":false,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/early-diagnosis-of-alzheimer-s-disease-using-machine-learning-a-multi-35922851","doi":"10.1186/s13195-022-01047-y","journal":"Alzheimer's research & therapy","n_participants":570,"pmid":"35922851","source_url":"https://pubmed.ncbi.nlm.nih.gov/35922851/","study_design":null,"title":"Early diagnosis of Alzheimer's disease using machine learning: a multi-diagnostic, generalizable approach","title_match":false,"year":2022},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/redox-proteomics-identification-of-specifically-carbonylated-proteins-25890254","doi":"10.1016/j.jprot.2015.04.005","journal":"Journal of proteomics","n_participants":null,"pmid":"25890254","source_url":"https://pubmed.ncbi.nlm.nih.gov/25890254/","study_design":null,"title":"Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage","title_match":false,"year":2015},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/early-dementia-diagnosis-mci-to-dementia-risk-prediction-and-the-role-35388959","doi":"10.1002/alz.12645","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35388959","source_url":"https://pubmed.ncbi.nlm.nih.gov/35388959/","study_design":null,"title":"Early dementia diagnosis, MCI-to-dementia risk prediction, and the role of machine learning methods for feature extraction from integrated biomarkers, in particular for EEG signal analysis","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/generalizable-reproducible-and-neuroscientifically-interpretable-32714766","doi":"10.1002/advs.202000675","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","n_participants":716,"pmid":"32714766","source_url":"https://pubmed.ncbi.nlm.nih.gov/32714766/","study_design":null,"title":"Generalizable, Reproducible, and Neuroscientifically Interpretable Imaging Biomarkers for Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/how-early-can-we-predict-alzheimer-s-disease-using-computational-23890839","doi":"10.1016/j.neurobiolaging.2013.06.015","journal":"Neurobiology of aging","n_participants":null,"pmid":"23890839","source_url":"https://pubmed.ncbi.nlm.nih.gov/23890839/","study_design":"longitudinal study","title":"How early can we predict Alzheimer's disease using computational anatomy?","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/functional-connectivity-of-white-matter-as-a-biomarker-of-cognitive-33064765","doi":"10.1371/journal.pone.0240513","journal":"PloS one","n_participants":null,"pmid":"33064765","source_url":"https://pubmed.ncbi.nlm.nih.gov/33064765/","study_design":null,"title":"Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/selecting-the-most-important-self-assessed-features-for-predicting-33244011","doi":"10.1038/s41598-020-77296-4","journal":"Scientific reports","n_participants":null,"pmid":"33244011","source_url":"https://pubmed.ncbi.nlm.nih.gov/33244011/","study_design":"longitudinal study","title":"Selecting the most important self-assessed features for predicting conversion to mild cognitive impairment with random forest and permutation-based methods","title_match":true,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cross-cohort-generalizability-of-deep-and-conventional-machine-34118592","doi":"10.1016/j.nicl.2021.102712","journal":"NeuroImage. Clinical","n_participants":199,"pmid":"34118592","source_url":"https://pubmed.ncbi.nlm.nih.gov/34118592/","study_design":null,"title":"Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/identification-of-mild-cognitive-impairment-from-speech-in-swedish-30498472","doi":"10.3389/fneur.2018.00975","journal":"Frontiers in neurology","n_participants":null,"pmid":"30498472","source_url":"https://pubmed.ncbi.nlm.nih.gov/30498472/","study_design":null,"title":"Identification of Mild Cognitive Impairment From Speech in Swedish Using Deep Sequential Neural Networks","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/prediction-of-incipient-alzheimer-s-disease-dementia-in-patients-with-27662309","doi":"10.3233/jad-160594","journal":"Journal of Alzheimer's disease : JAD","n_participants":86,"pmid":"27662309","source_url":"https://pubmed.ncbi.nlm.nih.gov/27662309/","study_design":null,"title":"Prediction of Incipient Alzheimer's Disease Dementia in Patients with Mild Cognitive Impairment","title_match":false,"year":2017},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/mri-characterizes-the-progressive-course-of-ad-and-predicts-29881340","doi":"10.3389/fnagi.2018.00135","journal":"Frontiers in aging neuroscience","n_participants":200,"pmid":"29881340","source_url":"https://pubmed.ncbi.nlm.nih.gov/29881340/","study_design":null,"title":"MRI Characterizes the Progressive Course of AD and Predicts Conversion to Alzheimer's Dementia 24 Months Before Probable Diagnosis","title_match":false,"year":2018},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/prediction-of-alzheimer-s-disease-dementia-with-mri-beyond-the-short-31078938","doi":"10.1016/j.nicl.2019.101837","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"31078938","source_url":"https://pubmed.ncbi.nlm.nih.gov/31078938/","study_design":null,"title":"Prediction of Alzheimer's disease dementia with MRI beyond the short-term: Implications for the design of predictive models","title_match":false,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/machine-learning-based-individual-assessment-of-cortical-atrophy-29515131","doi":"10.1038/s41598-018-22277-x","journal":"Scientific reports","n_participants":473,"pmid":"29515131","source_url":"https://pubmed.ncbi.nlm.nih.gov/29515131/","study_design":"longitudinal study","title":"Machine Learning-based Individual Assessment of Cortical Atrophy Pattern in Alzheimer's Disease Spectrum: Development of the Classifier and Longitudinal Evaluation","title_match":false,"year":2018},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cortical-thickness-from-mri-to-predict-conversion-from-mild-cognitive-34032515","doi":"10.1148/radiol.2021203383","journal":"Radiology","n_participants":75,"pmid":"34032515","source_url":"https://pubmed.ncbi.nlm.nih.gov/34032515/","study_design":null,"title":"Cortical Thickness from MRI to Predict Conversion from Mild Cognitive Impairment to Dementia in Parkinson Disease: A Machine Learning-based Model","title_match":true,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/cognitive-improvement-effects-of-electro-acupuncture-for-the-30621676","doi":"10.1186/s12906-018-2407-2","journal":"BMC complementary and alternative medicine","n_participants":103,"pmid":"30621676","source_url":"https://pubmed.ncbi.nlm.nih.gov/30621676/","study_design":"meta-analysis","title":"Cognitive improvement effects of electro-acupuncture for the treatment of MCI compared with Western medications: a systematic review and Meta-analysis","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/developing-a-machine-learning-model-for-detecting-depression-anxiety-37531702","doi":"10.1016/j.ijnurstu.2023.104562","journal":"International journal of nursing studies","n_participants":null,"pmid":"37531702","source_url":"https://pubmed.ncbi.nlm.nih.gov/37531702/","study_design":"cross-sectional","title":"Developing a machine learning model for detecting depression, anxiety, and apathy in older adults with mild cognitive impairment using speech and facial expressions: A cross-sectional observational study","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/classification-and-staging-of-parkinson-s-disease-using-video-based-36822878","doi":"10.1016/j.parkreldis.2023.105316","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"36822878","source_url":"https://pubmed.ncbi.nlm.nih.gov/36822878/","study_design":null,"title":"Classification and staging of Parkinson's disease using video-based eye tracking","title_match":false,"year":2023},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/systematic-review-fluid-biomarkers-and-machine-learning-methods-to-37838690","doi":"10.1186/s13195-023-01304-8","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"37838690","source_url":"https://pubmed.ncbi.nlm.nih.gov/37838690/","study_design":"systematic review","title":"Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/csf-complement-3-and-factor-h-are-staging-biomarkers-in-alzheimer-s-26887322","doi":"10.1186/s40478-016-0277-8","journal":"Acta neuropathologica communications","n_participants":230,"pmid":"26887322","source_url":"https://pubmed.ncbi.nlm.nih.gov/26887322/","study_design":null,"title":"CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/the-vallecas-project-a-cohort-to-identify-early-markers-and-26483681","doi":"10.3389/fnagi.2015.00181","journal":"Frontiers in aging neuroscience","n_participants":1169,"pmid":"26483681","source_url":"https://pubmed.ncbi.nlm.nih.gov/26483681/","study_design":"cohort study","title":"The Vallecas Project: A Cohort to Identify Early Markers and Mechanisms of Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/prediction-of-alzheimer-s-disease-progression-within-6-years-using-38924662","doi":"10.1002/alz.13886","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":166,"pmid":"38924662","source_url":"https://pubmed.ncbi.nlm.nih.gov/38924662/","study_design":null,"title":"Prediction of Alzheimer's disease progression within 6 years using speech: A novel approach leveraging language models","title_match":false,"year":2024},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/homocysteine-lowering-by-b-vitamins-slows-the-rate-of-accelerated-20838622","doi":"10.1371/journal.pone.0012244","journal":"PloS one","n_participants":271,"pmid":"20838622","source_url":"https://pubmed.ncbi.nlm.nih.gov/20838622/","study_design":"randomized controlled trial","title":"Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial","title_match":false,"year":2010},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/brainage-in-mild-cognitive-impaired-patients-predicting-the-23826273","doi":"10.1371/journal.pone.0067346","journal":"PloS one","n_participants":195,"pmid":"23826273","source_url":"https://pubmed.ncbi.nlm.nih.gov/23826273/","study_design":null,"title":"BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease","title_match":false,"year":2013},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/cognitive-and-clinical-outcomes-of-homocysteine-lowering-b-vitamin-21780182","doi":"10.1002/gps.2758","journal":"International journal of geriatric psychiatry","n_participants":133,"pmid":"21780182","source_url":"https://pubmed.ncbi.nlm.nih.gov/21780182/","study_design":null,"title":"Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial","title_match":false,"year":2012},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cognitive-function-in-patients-with-diabetes-mellitus-guidance-for-25728442","doi":"10.1016/s1474-4422(14)70249-2","journal":"The Lancet. Neurology","n_participants":null,"pmid":"25728442","source_url":"https://pubmed.ncbi.nlm.nih.gov/25728442/","study_design":null,"title":"Cognitive function in patients with diabetes mellitus: guidance for daily care","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/vascular-risk-factors-promote-conversion-from-mild-cognitive-21490316","doi":"10.1212/wnl.0b013e318217e7a4","journal":"Neurology","n_participants":837,"pmid":"21490316","source_url":"https://pubmed.ncbi.nlm.nih.gov/21490316/","study_design":null,"title":"Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease","title_match":true,"year":2011},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/rem-sleep-behavior-disorder-preceding-other-aspects-of-20668263","doi":"10.1212/wnl.0b013e3181ec7fac","journal":"Neurology","n_participants":27,"pmid":"20668263","source_url":"https://pubmed.ncbi.nlm.nih.gov/20668263/","study_design":null,"title":"REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/medial-temporal-lobe-atrophy-on-mri-predicts-dementia-in-patients-15249617","doi":"10.1212/01.wnl.0000133114.92694.93","journal":"Neurology","n_participants":null,"pmid":"15249617","source_url":"https://pubmed.ncbi.nlm.nih.gov/15249617/","study_design":null,"title":"Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment","title_match":false,"year":2004},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/evidence-of-oxidative-stress-in-alzheimer-s-disease-brain-and-19076432","doi":"10.1196/annals.1427.010","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"19076432","source_url":"https://pubmed.ncbi.nlm.nih.gov/19076432/","study_design":null,"title":"Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/depression-in-dementia-epidemiology-mechanisms-and-treatment-21926624","doi":"10.1097/yco.0b013e32834bb9d4","journal":"Current opinion in psychiatry","n_participants":null,"pmid":"21926624","source_url":"https://pubmed.ncbi.nlm.nih.gov/21926624/","study_design":null,"title":"Depression in dementia:  epidemiology, mechanisms, and treatment","title_match":false,"year":2011},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/redox-proteomics-and-amyloid-peptide-insights-into-alzheimer-disease-30216447","doi":"10.1111/jnc.14589","journal":"Journal of neurochemistry","n_participants":null,"pmid":"30216447","source_url":"https://pubmed.ncbi.nlm.nih.gov/30216447/","study_design":null,"title":"Redox proteomics and amyloid \u03b2-peptide: insights into Alzheimer disease","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alzheimer-related-altered-white-matter-microstructural-integrity-in-33204811","doi":"10.1002/dad2.12040","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"33204811","source_url":"https://pubmed.ncbi.nlm.nih.gov/33204811/","study_design":null,"title":"Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD?","title_match":false,"year":2020},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/early-diagnosis-of-alzheimer-disease-with-positron-emission-tomography-10850738","doi":"10.1097/00002093-200000001-00016","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"10850738","source_url":"https://pubmed.ncbi.nlm.nih.gov/10850738/","study_design":null,"title":"Early diagnosis of Alzheimer disease with positron emission tomography","title_match":false,"year":2000},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/new-insights-into-the-genetic-etiology-of-alzheimer-s-disease-and-35379992","doi":"10.1038/s41588-022-01024-z","journal":"Nature genetics","n_participants":null,"pmid":"35379992","source_url":"https://pubmed.ncbi.nlm.nih.gov/35379992/","study_design":null,"title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","title_match":false,"year":2022},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-neuroimaging-initiative-adni-clinical-20042704","doi":"10.1212/wnl.0b013e3181cb3e25","journal":"Neurology","n_participants":819,"pmid":"20042704","source_url":"https://pubmed.ncbi.nlm.nih.gov/20042704/","study_design":null,"title":"Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization","title_match":false,"year":2010},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/oxidative-stress-dysfunctional-glucose-metabolism-and-alzheimer-30737462","doi":"10.1038/s41583-019-0132-6","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"30737462","source_url":"https://pubmed.ncbi.nlm.nih.gov/30737462/","study_design":null,"title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","title_match":false,"year":2019},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/practice-parameter-early-detection-of-dementia-mild-cognitive-11342677","doi":"10.1212/wnl.56.9.1133","journal":"Neurology","n_participants":null,"pmid":"11342677","source_url":"https://pubmed.ncbi.nlm.nih.gov/11342677/","study_design":null,"title":"Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review) [RETIRED]. Report of the Quality Standards Subcommittee of the American Academy of Neurology","title_match":false,"year":2001},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-represents-early-stage-alzheimer-disease-11255443","doi":"10.1001/archneur.58.3.397","journal":"Archives of neurology","n_participants":177,"pmid":"11255443","source_url":"https://pubmed.ncbi.nlm.nih.gov/11255443/","study_design":null,"title":"Mild cognitive impairment represents early-stage Alzheimer disease","title_match":false,"year":2001},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-a-concept-in-evolution-24605806","doi":"10.1111/joim.12190","journal":"Journal of internal medicine","n_participants":null,"pmid":"24605806","source_url":"https://pubmed.ncbi.nlm.nih.gov/24605806/","study_design":"longitudinal study","title":"Mild cognitive impairment: a concept in evolution","title_match":false,"year":2014},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/vitamin-e-and-donepezil-for-the-treatment-of-mild-cognitive-impairment-15829527","doi":"10.1056/nejmoa050151","journal":"The New England journal of medicine","n_participants":769,"pmid":"15829527","source_url":"https://pubmed.ncbi.nlm.nih.gov/15829527/","study_design":null,"title":"Vitamin E and donepezil for the treatment of mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/sodium-oligomannate-therapeutically-remodels-gut-microbiota-and-31488882","doi":"10.1038/s41422-019-0216-x","journal":"Cell research","n_participants":null,"pmid":"31488882","source_url":"https://pubmed.ncbi.nlm.nih.gov/31488882/","study_design":"clinical trial","title":"Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression","title_match":false,"year":2019},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-of-alzheimer-s-disease-concord-with-amyloid-pet-and-29499171","doi":"10.1016/j.jalz.2018.01.010","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":277,"pmid":"29499171","source_url":"https://pubmed.ncbi.nlm.nih.gov/29499171/","study_design":null,"title":"CSF biomarkers of Alzheimer's disease concord with amyloid-\u03b2 PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts","title_match":false,"year":2018},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/neuropsychological-criteria-for-mild-cognitive-impairment-improves-24844687","doi":"10.3233/jad-140276","journal":"Journal of Alzheimer's disease : JAD","n_participants":846,"pmid":"24844687","source_url":"https://pubmed.ncbi.nlm.nih.gov/24844687/","study_design":null,"title":"Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates","title_match":true,"year":2014},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-expression-of-microrna-mir-107-decreases-early-in-alzheimer-s-18234899","doi":"10.1523/jneurosci.5065-07.2008","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"18234899","source_url":"https://pubmed.ncbi.nlm.nih.gov/18234899/","study_design":null,"title":"The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1","title_match":false,"year":2008},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/precursor-form-of-brain-derived-neurotrophic-factor-and-mature-brain-15935057","doi":"10.1111/j.1471-4159.2005.03135.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"15935057","source_url":"https://pubmed.ncbi.nlm.nih.gov/15935057/","study_design":null,"title":"Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease","title_match":false,"year":2005},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/permanent-bilateral-common-carotid-artery-occlusion-in-the-rat-a-17296232","doi":"10.1016/j.brainresrev.2007.01.003","journal":"Brain research reviews","n_participants":null,"pmid":"17296232","source_url":"https://pubmed.ncbi.nlm.nih.gov/17296232/","study_design":null,"title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","title_match":false,"year":2007},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/age-apoe-and-sex-triad-of-risk-of-alzheimer-s-disease-26969397","doi":"10.1016/j.jsbmb.2016.03.012","journal":"The Journal of steroid biochemistry and molecular biology","n_participants":null,"pmid":"26969397","source_url":"https://pubmed.ncbi.nlm.nih.gov/26969397/","study_design":null,"title":"Age, APOE and sex: Triad of risk of Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/new-clinical-subtypes-of-parkinson-disease-and-their-longitudinal-26076039","doi":"10.1001/jamaneurol.2015.0703","journal":"JAMA neurology","n_participants":113,"pmid":"26076039","source_url":"https://pubmed.ncbi.nlm.nih.gov/26076039/","study_design":"cohort study","title":"New Clinical Subtypes of Parkinson Disease and Their Longitudinal Progression: A Prospective Cohort Comparison With Other Phenotypes","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/brain-glucose-hypometabolism-and-oxidative-stress-in-preclinical-19076441","doi":"10.1196/annals.1427.007","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"19076441","source_url":"https://pubmed.ncbi.nlm.nih.gov/19076441/","study_design":null,"title":"Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-mci-in-medical-practice-a-critical-review-16549412","doi":"10.1136/jnnp.2005.085332","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"16549412","source_url":"https://pubmed.ncbi.nlm.nih.gov/16549412/","study_design":null,"title":"Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease","title_match":false,"year":2006},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/oxidative-stress-in-the-progression-of-alzheimer-disease-in-the-20084018","doi":"10.1097/nen.0b013e3181cb5af4","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"20084018","source_url":"https://pubmed.ncbi.nlm.nih.gov/20084018/","study_design":null,"title":"Oxidative stress in the progression of Alzheimer disease in the frontal cortex","title_match":false,"year":2010},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/working-memory-and-executive-function-decline-across-normal-aging-26550575","doi":"10.1155/2015/748212","journal":"BioMed research international","n_participants":null,"pmid":"26550575","source_url":"https://pubmed.ncbi.nlm.nih.gov/26550575/","study_design":null,"title":"Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/in-vivo-cortical-spreading-pattern-of-tau-and-amyloid-in-the-27323247","doi":"10.1002/ana.24711","journal":"Annals of neurology","n_participants":195,"pmid":"27323247","source_url":"https://pubmed.ncbi.nlm.nih.gov/27323247/","study_design":null,"title":"In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum","title_match":false,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-an-overview-18204414","doi":"10.1017/s1092852900016151","journal":"CNS spectrums","n_participants":null,"pmid":"18204414","source_url":"https://pubmed.ncbi.nlm.nih.gov/18204414/","study_design":null,"title":"Mild cognitive impairment: an overview","title_match":false,"year":2008},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-pet-positive-cognitively-unimpaired-individuals-are-36357681","doi":"10.1038/s41591-022-02049-x","journal":"Nature medicine","n_participants":1325,"pmid":"36357681","source_url":"https://pubmed.ncbi.nlm.nih.gov/36357681/","study_design":null,"title":"Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline","title_match":false,"year":2022},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/prediction-of-future-alzheimer-s-disease-dementia-using-plasma-34031605","doi":"10.1038/s41591-021-01348-z","journal":"Nature medicine","n_participants":340,"pmid":"34031605","source_url":"https://pubmed.ncbi.nlm.nih.gov/34031605/","study_design":null,"title":"Prediction of future Alzheimer's disease dementia using plasma phospho-tau combined with other accessible measures","title_match":false,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/progression-of-mild-cognitive-impairment-to-dementia-in-clinic-vs-19752306","doi":"10.1001/archneurol.2009.106","journal":"Archives of neurology","n_participants":28,"pmid":"19752306","source_url":"https://pubmed.ncbi.nlm.nih.gov/19752306/","study_design":"longitudinal study","title":"Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts","title_match":true,"year":2009},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/preserved-cognition-in-patients-with-early-alzheimer-disease-and-16286438","doi":"10.1176/appi.ajgp.13.11.950","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":20,"pmid":"16286438","source_url":"https://pubmed.ncbi.nlm.nih.gov/16286438/","study_design":null,"title":"Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study","title_match":false,"year":2005},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/3d-maps-from-multiple-mri-illustrate-changing-atrophy-patterns-as-17533169","doi":"10.1093/brain/awm112","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"17533169","source_url":"https://pubmed.ncbi.nlm.nih.gov/17533169/","study_design":null,"title":"3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2007},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/abeta-toxicity-in-alzheimer-s-disease-globular-oligomers-addls-as-new-12176077","doi":"10.1016/s0197-0186(02)00050-5","journal":"Neurochemistry international","n_participants":null,"pmid":"12176077","source_url":"https://pubmed.ncbi.nlm.nih.gov/12176077/","study_design":null,"title":"Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets","title_match":false,"year":2002},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-disease-neuroimaging-initiative-progress-report-and-20451868","doi":"10.1016/j.jalz.2010.03.007","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"20451868","source_url":"https://pubmed.ncbi.nlm.nih.gov/20451868/","study_design":null,"title":"The Alzheimer's disease neuroimaging initiative: progress report and future plans","title_match":false,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/metabolic-network-failures-in-alzheimer-s-disease-a-biochemical-road-28341160","doi":"10.1016/j.jalz.2017.01.020","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"28341160","source_url":"https://pubmed.ncbi.nlm.nih.gov/28341160/","study_design":null,"title":"Metabolic network failures in Alzheimer's disease: A biochemical road\u00a0map","title_match":false,"year":2017},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/longitudinal-pattern-of-regional-brain-volume-change-differentiates-19487648","doi":"10.1212/wnl.0b013e3181a82634","journal":"Neurology","n_participants":1017,"pmid":"19487648","source_url":"https://pubmed.ncbi.nlm.nih.gov/19487648/","study_design":"longitudinal study","title":"Longitudinal pattern of regional brain volume change differentiates normal aging from MCI","title_match":false,"year":2009},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/brain-beta-amyloid-measures-and-magnetic-resonance-imaging-atrophy-20935035","doi":"10.1093/brain/awq277","journal":"Brain : a journal of neurology","n_participants":165,"pmid":"20935035","source_url":"https://pubmed.ncbi.nlm.nih.gov/20935035/","study_design":null,"title":"Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2010},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/ventricular-enlargement-as-a-possible-measure-of-alzheimer-s-disease-18669512","doi":"10.1093/brain/awn146","journal":"Brain : a journal of neurology","n_participants":152,"pmid":"18669512","source_url":"https://pubmed.ncbi.nlm.nih.gov/18669512/","study_design":null,"title":"Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database","title_match":false,"year":2008},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/subtypes-of-mild-cognitive-impairment-in-parkinson-s-disease-16721732","doi":"10.1002/mds.20974","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":34,"pmid":"16721732","source_url":"https://pubmed.ncbi.nlm.nih.gov/16721732/","study_design":null,"title":"Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia","title_match":true,"year":2006},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/evidence-of-increased-oxidative-damage-in-subjects-with-mild-15824339","doi":"10.1212/01.wnl.0000156156.13641.ba","journal":"Neurology","n_participants":null,"pmid":"15824339","source_url":"https://pubmed.ncbi.nlm.nih.gov/15824339/","study_design":null,"title":"Evidence of increased oxidative damage in subjects with mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/baseline-and-longitudinal-patterns-of-brain-atrophy-in-mci-patients-19027862","doi":"10.1016/j.neuroimage.2008.10.031","journal":"NeuroImage","n_participants":null,"pmid":"19027862","source_url":"https://pubmed.ncbi.nlm.nih.gov/19027862/","study_design":null,"title":"Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI","title_match":true,"year":2009},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/cerebral-metabolic-changes-accompanying-conversion-of-mild-cognitive-12764551","doi":"10.1007/s00259-003-1194-1","journal":"European journal of nuclear medicine and molecular imaging","n_participants":null,"pmid":"12764551","source_url":"https://pubmed.ncbi.nlm.nih.gov/12764551/","study_design":"longitudinal study","title":"Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study","title_match":true,"year":2003},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/using-voxel-based-morphometry-to-map-the-structural-changes-15979341","doi":"10.1016/j.neuroimage.2005.05.015","journal":"NeuroImage","n_participants":null,"pmid":"15979341","source_url":"https://pubmed.ncbi.nlm.nih.gov/15979341/","study_design":"longitudinal study","title":"Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study","title_match":true,"year":2005},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-drug-development-pipeline-2023-37251912","doi":"10.1002/trc2.12385","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":36,"pmid":"37251912","source_url":"https://pubmed.ncbi.nlm.nih.gov/37251912/","study_design":"clinical trial","title":"Alzheimer's disease drug development pipeline: 2023","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-disease-neuroimaging-initiative-3-continued-27931796","doi":"10.1016/j.jalz.2016.10.006","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"27931796","source_url":"https://pubmed.ncbi.nlm.nih.gov/27931796/","study_design":null,"title":"The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement","title_match":false,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/body-fluid-cytokine-levels-in-mild-cognitive-impairment-and-alzheimer-24567119","doi":"10.1007/s12035-014-8657-1","journal":"Molecular neurobiology","n_participants":null,"pmid":"24567119","source_url":"https://pubmed.ncbi.nlm.nih.gov/24567119/","study_design":"longitudinal study","title":"Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview","title_match":false,"year":2014},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/identification-of-altered-metabolic-pathways-in-plasma-and-csf-in-23700429","doi":"10.1371/journal.pone.0063644","journal":"PloS one","n_participants":null,"pmid":"23700429","source_url":"https://pubmed.ncbi.nlm.nih.gov/23700429/","study_design":null,"title":"Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics","title_match":false,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/regional-profiles-of-the-candidate-tau-pet-ligand-18f-av-1451-26936940","doi":"10.1093/brain/aww023","journal":"Brain : a journal of neurology","n_participants":14,"pmid":"26936940","source_url":"https://pubmed.ncbi.nlm.nih.gov/26936940/","study_design":null,"title":"Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages","title_match":false,"year":2016},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/a-review-on-neuroimaging-based-classification-studies-and-associated-28414186","doi":"10.1016/j.neuroimage.2017.03.057","journal":"NeuroImage","n_participants":null,"pmid":"28414186","source_url":"https://pubmed.ncbi.nlm.nih.gov/28414186/","study_design":null,"title":"A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer's disease and its prodromal stages","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/functional-deficits-in-patients-with-mild-cognitive-impairment-11889240","doi":"10.1212/wnl.58.5.758","journal":"Neurology","n_participants":null,"pmid":"11889240","source_url":"https://pubmed.ncbi.nlm.nih.gov/11889240/","study_design":null,"title":"Functional deficits in patients with mild cognitive impairment: prediction of AD","title_match":false,"year":2002},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/preventing-alzheimer-s-disease-related-gray-matter-atrophy-by-b-23690582","doi":"10.1073/pnas.1301816110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"23690582","source_url":"https://pubmed.ncbi.nlm.nih.gov/23690582/","study_design":null,"title":"Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/simultaneous-measurement-of-beta-amyloid-1-42-total-tau-and-15563479","doi":"10.1373/clinchem.2004.039347","journal":"Clinical chemistry","n_participants":null,"pmid":"15563479","source_url":"https://pubmed.ncbi.nlm.nih.gov/15563479/","study_design":null,"title":"Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology","title_match":false,"year":2005},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/serum-antibodies-to-periodontal-pathogens-are-a-risk-factor-for-22546352","doi":"10.1016/j.jalz.2011.04.006","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":158,"pmid":"22546352","source_url":"https://pubmed.ncbi.nlm.nih.gov/22546352/","study_design":"cohort study","title":"Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/regional-metabolic-patterns-in-mild-cognitive-impairment-and-10908893","doi":"10.1212/wnl.55.2.210","journal":"Neurology","n_participants":21,"pmid":"10908893","source_url":"https://pubmed.ncbi.nlm.nih.gov/10908893/","study_design":"cross-sectional","title":"Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study","title_match":false,"year":2000},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuropathologic-substrate-of-mild-cognitive-impairment-16401735","doi":"10.1001/archneur.63.1.38","journal":"Archives of neurology","n_participants":null,"pmid":"16401735","source_url":"https://pubmed.ncbi.nlm.nih.gov/16401735/","study_design":null,"title":"Neuropathologic substrate of mild cognitive impairment","title_match":false,"year":2006},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/marked-gender-differences-in-progression-of-mild-cognitive-impairment-26451386","doi":"10.1016/j.trci.2015.07.001","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"26451386","source_url":"https://pubmed.ncbi.nlm.nih.gov/26451386/","study_design":"longitudinal study","title":"Marked gender differences in progression of mild cognitive impairment over 8 years","title_match":true,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/spatial-patterns-of-brain-atrophy-in-mci-patients-identified-via-high-18053747","doi":"10.1016/j.neuroimage.2007.10.031","journal":"NeuroImage","n_participants":null,"pmid":"18053747","source_url":"https://pubmed.ncbi.nlm.nih.gov/18053747/","study_design":null,"title":"Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/oxidative-stress-amyloid-peptide-and-altered-key-molecular-pathways-29562527","doi":"10.3233/jad-170543","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29562527","source_url":"https://pubmed.ncbi.nlm.nih.gov/29562527/","study_design":null,"title":"Oxidative Stress, Amyloid-\u03b2 Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-in-clinical-practice-a-review-article-30068225","doi":"10.1177/1533317518791401","journal":"American journal of Alzheimer's disease and other dementias","n_participants":null,"pmid":"30068225","source_url":"https://pubmed.ncbi.nlm.nih.gov/30068225/","study_design":null,"title":"Mild Cognitive Impairment in Clinical Practice: A Review Article","title_match":false,"year":2018},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/longitudinal-plasma-p-tau217-is-increased-in-early-stages-of-33068398","doi":"10.1093/brain/awaa286","journal":"Brain : a journal of neurology","n_participants":62,"pmid":"33068398","source_url":"https://pubmed.ncbi.nlm.nih.gov/33068398/","study_design":"longitudinal study","title":"Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/the-sydney-memory-and-ageing-study-mas-methodology-and-baseline-20637138","doi":"10.1017/s1041610210001067","journal":"International psychogeriatrics","n_participants":1037,"pmid":"20637138","source_url":"https://pubmed.ncbi.nlm.nih.gov/20637138/","study_design":"longitudinal study","title":"The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years","title_match":false,"year":2010},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/association-of-plasma-clusterin-concentration-with-severity-pathology-20603455","doi":"10.1001/archgenpsychiatry.2010.78","journal":"Archives of general psychiatry","n_participants":null,"pmid":"20603455","source_url":"https://pubmed.ncbi.nlm.nih.gov/20603455/","study_design":"longitudinal study","title":"Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-dual-task-gait-with-incident-dementia-in-mild-28505243","doi":"10.1001/jamaneurol.2017.0643","journal":"JAMA neurology","n_participants":112,"pmid":"28505243","source_url":"https://pubmed.ncbi.nlm.nih.gov/28505243/","study_design":"cohort study","title":"Association of Dual-Task Gait With Incident Dementia in Mild Cognitive Impairment: Results From the Gait and Brain Study","title_match":false,"year":2017},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/ferritin-levels-in-the-cerebrospinal-fluid-predict-alzheimer-s-25988319","doi":"10.1038/ncomms7760","journal":"Nature communications","n_participants":null,"pmid":"25988319","source_url":"https://pubmed.ncbi.nlm.nih.gov/25988319/","study_design":"longitudinal study","title":"Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/spatial-patterns-of-cortical-thinning-in-mild-cognitive-impairment-17008332","doi":"10.1093/brain/awl256","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"17008332","source_url":"https://pubmed.ncbi.nlm.nih.gov/17008332/","study_design":null,"title":"Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/alteration-of-mtor-signaling-occurs-early-in-the-progression-of-25645581","doi":"10.1111/jnc.13037","journal":"Journal of neurochemistry","n_participants":null,"pmid":"25645581","source_url":"https://pubmed.ncbi.nlm.nih.gov/25645581/","study_design":null,"title":"Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD","title_match":true,"year":2015},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/the-association-of-neuropsychiatric-symptoms-in-mci-with-incident-23567400","doi":"10.1016/j.jagp.2013.01.006","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":1821,"pmid":"23567400","source_url":"https://pubmed.ncbi.nlm.nih.gov/23567400/","study_design":"cohort study","title":"The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/redox-proteomics-identification-of-oxidatively-modified-hippocampal-16466929","doi":"10.1016/j.nbd.2005.11.002","journal":"Neurobiology of disease","n_participants":null,"pmid":"16466929","source_url":"https://pubmed.ncbi.nlm.nih.gov/16466929/","study_design":null,"title":"Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/increased-levels-of-4-hydroxynonenal-and-acrolein-neurotoxic-markers-15993986","doi":"10.1016/j.neurobiolaging.2005.06.004","journal":"Neurobiology of aging","n_participants":null,"pmid":"15993986","source_url":"https://pubmed.ncbi.nlm.nih.gov/15993986/","study_design":null,"title":"Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/early-diagnosis-of-alzheimer-s-disease-contribution-of-structural-12595205","doi":"10.1016/s1053-8119(02)00026-5","journal":"NeuroImage","n_participants":null,"pmid":"12595205","source_url":"https://pubmed.ncbi.nlm.nih.gov/12595205/","study_design":"longitudinal study","title":"Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging","title_match":false,"year":2003},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/increased-soluble-trem2-in-cerebrospinal-fluid-is-associated-with-31462511","doi":"10.1126/scitranslmed.aav6221","journal":"Science translational medicine","n_participants":null,"pmid":"31462511","source_url":"https://pubmed.ncbi.nlm.nih.gov/31462511/","study_design":null,"title":"Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/late-life-depression-mild-cognitive-impairment-and-dementia-23599941","doi":"10.1001/jamaneurol.2013.603","journal":"JAMA neurology","n_participants":2160,"pmid":"23599941","source_url":"https://pubmed.ncbi.nlm.nih.gov/23599941/","study_design":"cohort study","title":"Late-life depression, mild cognitive impairment, and dementia","title_match":false,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/review-systemic-inflammation-and-alzheimer-s-disease-23046210","doi":"10.1111/j.1365-2990.2012.01307.x","journal":"Neuropathology and applied neurobiology","n_participants":null,"pmid":"23046210","source_url":"https://pubmed.ncbi.nlm.nih.gov/23046210/","study_design":null,"title":"Review: systemic inflammation and Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/predictors-of-progression-from-mild-cognitive-impairment-to-alzheimer-17485646","doi":"10.1212/01.wnl.0000260968.92345.3f","journal":"Neurology","n_participants":185,"pmid":"17485646","source_url":"https://pubmed.ncbi.nlm.nih.gov/17485646/","study_design":null,"title":"Predictors of progression from mild cognitive impairment to Alzheimer disease","title_match":true,"year":2007},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/brain-glutathione-levels-a-novel-biomarker-for-mild-cognitive-26003861","doi":"10.1016/j.biopsych.2015.04.005","journal":"Biological psychiatry","n_participants":null,"pmid":"26003861","source_url":"https://pubmed.ncbi.nlm.nih.gov/26003861/","study_design":null,"title":"Brain glutathione levels--a novel biomarker for mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/risk-factors-for-predicting-progression-from-mild-cognitive-26001840","doi":"10.1136/jnnp-2014-310095","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":14821,"pmid":"26001840","source_url":"https://pubmed.ncbi.nlm.nih.gov/26001840/","study_design":"meta-analysis","title":"Risk factors for predicting progression from mild cognitive impairment to Alzheimer's disease: a systematic review and meta-analysis of cohort studies","title_match":true,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/long-term-exposure-to-traffic-related-particulate-matter-impairs-19733348","doi":"10.1016/j.envres.2009.08.003","journal":"Environmental research","n_participants":null,"pmid":"19733348","source_url":"https://pubmed.ncbi.nlm.nih.gov/19733348/","study_design":null,"title":"Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly","title_match":false,"year":2009},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/mitochondrial-dysfunction-oxidative-stress-neuroinflammation-and-34751136","doi":"10.1016/j.arr.2021.101503","journal":"Ageing research reviews","n_participants":null,"pmid":"34751136","source_url":"https://pubmed.ncbi.nlm.nih.gov/34751136/","study_design":"meta-analysis","title":"Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies","title_match":false,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-as-prescreener-for-the-earliest-alzheimer-pathological-30196548","doi":"10.1002/ana.25334","journal":"Annals of neurology","n_participants":248,"pmid":"30196548","source_url":"https://pubmed.ncbi.nlm.nih.gov/30196548/","study_design":null,"title":"Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes","title_match":false,"year":2018},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/predictive-markers-for-ad-in-a-multi-modality-framework-an-analysis-21146621","doi":"10.1016/j.neuroimage.2010.10.081","journal":"NeuroImage","n_participants":null,"pmid":"21146621","source_url":"https://pubmed.ncbi.nlm.nih.gov/21146621/","study_design":null,"title":"Predictive markers for AD in a multi-modality framework: an analysis of MCI progression in the ADNI population","title_match":true,"year":2011},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/changes-of-some-oxidative-stress-markers-in-the-serum-of-patients-19914330","doi":"10.1016/j.neulet.2009.11.033","journal":"Neuroscience letters","n_participants":45,"pmid":"19914330","source_url":"https://pubmed.ncbi.nlm.nih.gov/19914330/","study_design":null,"title":"Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/locus-coeruleus-cellular-and-molecular-pathology-during-the-28109312","doi":"10.1186/s40478-017-0411-2","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"28109312","source_url":"https://pubmed.ncbi.nlm.nih.gov/28109312/","study_design":null,"title":"Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/prognosis-of-mild-cognitive-impairment-in-early-parkinson-disease-the-23529397","doi":"10.1001/jamaneurol.2013.2110","journal":"JAMA neurology","n_participants":182,"pmid":"23529397","source_url":"https://pubmed.ncbi.nlm.nih.gov/23529397/","study_design":"cohort study","title":"Prognosis of mild cognitive impairment in early Parkinson disease: the Norwegian ParkWest study","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/synaptic-loss-in-the-inferior-temporal-gyrus-in-mild-cognitive-21297265","doi":"10.3233/jad-2011-101782","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21297265","source_url":"https://pubmed.ncbi.nlm.nih.gov/21297265/","study_design":null,"title":"Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/neuroimaging-markers-for-the-prediction-and-early-diagnosis-of-21696834","doi":"10.1016/j.tins.2011.05.005","journal":"Trends in neurosciences","n_participants":null,"pmid":"21696834","source_url":"https://pubmed.ncbi.nlm.nih.gov/21696834/","study_design":null,"title":"Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia","title_match":false,"year":2011},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/microglial-activation-correlates-in-vivo-with-both-tau-and-amyloid-in-30052812","doi":"10.1093/brain/awy188","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"30052812","source_url":"https://pubmed.ncbi.nlm.nih.gov/30052812/","study_design":null,"title":"Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cognitive-performance-and-neuropsychiatric-symptoms-in-early-25737166","doi":"10.1002/mds.26170","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"25737166","source_url":"https://pubmed.ncbi.nlm.nih.gov/25737166/","study_design":null,"title":"Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cerebral-quantitative-susceptibility-mapping-predicts-amyloid-related-28899019","doi":"10.1093/brain/awx137","journal":"Brain : a journal of neurology","n_participants":64,"pmid":"28899019","source_url":"https://pubmed.ncbi.nlm.nih.gov/28899019/","study_design":null,"title":"Cerebral quantitative susceptibility mapping predicts amyloid-\u03b2-related cognitive decline","title_match":false,"year":2017},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/neural-correlates-of-alzheimer-s-disease-and-mild-cognitive-19463961","doi":"10.1016/j.neuroimage.2009.05.037","journal":"NeuroImage","n_participants":1351,"pmid":"19463961","source_url":"https://pubmed.ncbi.nlm.nih.gov/19463961/","study_design":"meta-analysis","title":"Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients","title_match":false,"year":2009},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/longitudinal-progression-of-alzheimer-s-like-patterns-of-atrophy-in-19416949","doi":"10.1093/brain/awp091","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"19416949","source_url":"https://pubmed.ncbi.nlm.nih.gov/19416949/","study_design":"longitudinal study","title":"Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index","title_match":false,"year":2009},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/a-data-driven-model-of-biomarker-changes-in-sporadic-alzheimer-s-25012224","doi":"10.1093/brain/awu176","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"25012224","source_url":"https://pubmed.ncbi.nlm.nih.gov/25012224/","study_design":null,"title":"A data-driven model of biomarker changes in sporadic Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/intrathecal-chemokine-synthesis-in-mild-cognitive-impairment-and-16606766","doi":"10.1001/archneur.63.4.538","journal":"Archives of neurology","n_participants":36,"pmid":"16606766","source_url":"https://pubmed.ncbi.nlm.nih.gov/16606766/","study_design":"longitudinal study","title":"Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease","title_match":false,"year":2006},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/neuropsychological-measures-that-predict-progression-from-mild-29019061","doi":"10.1007/s11065-017-9361-5","journal":"Neuropsychology review","n_participants":2365,"pmid":"29019061","source_url":"https://pubmed.ncbi.nlm.nih.gov/29019061/","study_design":"longitudinal study","title":"Neuropsychological Measures that Predict Progression from Mild Cognitive Impairment to Alzheimer's type dementia in Older Adults: a Systematic Review and Meta-Analysis","title_match":true,"year":2017},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/role-of-oxidative-stress-in-the-progression-of-alzheimer-s-disease-20061649","doi":"10.3233/jad-2010-1222","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20061649","source_url":"https://pubmed.ncbi.nlm.nih.gov/20061649/","study_design":null,"title":"Role of oxidative stress in the progression of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/a-multi-model-deep-convolutional-neural-network-for-automatic-31837471","doi":"10.1016/j.neuroimage.2019.116459","journal":"NeuroImage","n_participants":null,"pmid":"31837471","source_url":"https://pubmed.ncbi.nlm.nih.gov/31837471/","study_design":null,"title":"A multi-model deep convolutional neural network for automatic hippocampus segmentation and classification in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/depression-anxiety-and-apathy-in-mild-cognitive-impairment-current-32082139","doi":"10.3389/fnagi.2020.00009","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"32082139","source_url":"https://pubmed.ncbi.nlm.nih.gov/32082139/","study_design":null,"title":"Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/microarray-analysis-of-hippocampal-ca1-neurons-implicates-early-20655510","doi":"10.1016/j.biopsych.2010.05.030","journal":"Biological psychiatry","n_participants":null,"pmid":"20655510","source_url":"https://pubmed.ncbi.nlm.nih.gov/20655510/","study_design":null,"title":"Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression","title_match":false,"year":2010},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tracking-atrophy-progression-in-familial-alzheimer-s-disease-a-serial-16987729","doi":"10.1016/s1474-4422(06)70550-6","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16987729","source_url":"https://pubmed.ncbi.nlm.nih.gov/16987729/","study_design":"cross-sectional","title":"Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study","title_match":false,"year":2006},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/outcomes-of-mild-cognitive-impairment-by-definition-a-population-study-21670400","doi":"10.1001/archneurol.2011.101","journal":"Archives of neurology","n_participants":1982,"pmid":"21670400","source_url":"https://pubmed.ncbi.nlm.nih.gov/21670400/","study_design":null,"title":"Outcomes of mild cognitive impairment by definition: a population study","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/update-on-the-biomarker-core-of-the-alzheimer-s-disease-neuroimaging-20451871","doi":"10.1016/j.jalz.2010.03.008","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"20451871","source_url":"https://pubmed.ncbi.nlm.nih.gov/20451871/","study_design":null,"title":"Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-quantitative-structural-neuroimaging-for-detection-19201945","doi":"10.1148/radiol.2511080924","journal":"Radiology","n_participants":84,"pmid":"19201945","source_url":"https://pubmed.ncbi.nlm.nih.gov/19201945/","study_design":null,"title":"Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/defective-dna-base-excision-repair-in-brain-from-individuals-with-17704129","doi":"10.1093/nar/gkm605","journal":"Nucleic acids research","n_participants":null,"pmid":"17704129","source_url":"https://pubmed.ncbi.nlm.nih.gov/17704129/","study_design":null,"title":"Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/ccl2-is-associated-with-a-faster-rate-of-cognitive-decline-during-22303443","doi":"10.1371/journal.pone.0030525","journal":"PloS one","n_participants":119,"pmid":"22303443","source_url":"https://pubmed.ncbi.nlm.nih.gov/22303443/","study_design":null,"title":"CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/spatial-navigation-deficit-in-amnestic-mild-cognitive-impairment-17360474","doi":"10.1073/pnas.0611314104","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":21,"pmid":"17360474","source_url":"https://pubmed.ncbi.nlm.nih.gov/17360474/","study_design":null,"title":"Spatial navigation deficit in amnestic mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/elevation-of-glutathione-as-a-therapeutic-strategy-in-alzheimer-22015471","doi":"10.1016/j.bbadis.2011.10.003","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"22015471","source_url":"https://pubmed.ncbi.nlm.nih.gov/22015471/","study_design":null,"title":"Elevation of glutathione as a therapeutic strategy in Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/effect-of-rivastigmine-on-delay-to-diagnosis-of-alzheimer-s-disease-17509485","doi":"10.1016/s1474-4422(07)70109-6","journal":"The Lancet. Neurology","n_participants":null,"pmid":"17509485","source_url":"https://pubmed.ncbi.nlm.nih.gov/17509485/","study_design":null,"title":"Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study","title_match":false,"year":2007},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/subtype-of-mild-cognitive-impairment-and-progression-to-dementia-and-16940725","doi":"10.1159/000095427","journal":"Dementia and geriatric cognitive disorders","n_participants":327,"pmid":"16940725","source_url":"https://pubmed.ncbi.nlm.nih.gov/16940725/","study_design":"longitudinal study","title":"Subtype of mild cognitive impairment and progression to dementia and death","title_match":true,"year":2006},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/ultrastructural-hippocampal-and-white-matter-alterations-in-mild-15087585","doi":"10.1159/000077817","journal":"Dementia and geriatric cognitive disorders","n_participants":14,"pmid":"15087585","source_url":"https://pubmed.ncbi.nlm.nih.gov/15087585/","study_design":null,"title":"Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study","title_match":false,"year":2004},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/neuroinflammation-in-mild-cognitive-impairment-and-alzheimer-s-30610927","doi":"10.1016/j.arr.2019.01.002","journal":"Ageing research reviews","n_participants":null,"pmid":"30610927","source_url":"https://pubmed.ncbi.nlm.nih.gov/30610927/","study_design":"meta-analysis","title":"Neuroinflammation in mild cognitive impairment and Alzheimer's disease: A meta-analysis","title_match":false,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/a-parameter-efficient-deep-learning-approach-to-predict-conversion-30654174","doi":"10.1016/j.neuroimage.2019.01.031","journal":"NeuroImage","n_participants":785,"pmid":"30654174","source_url":"https://pubmed.ncbi.nlm.nih.gov/30654174/","study_design":null,"title":"A parameter-efficient deep learning approach to predict conversion from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/proline-isomer-specific-antibodies-reveal-the-early-pathogenic-tau-22464332","doi":"10.1016/j.cell.2012.02.016","journal":"Cell","n_participants":null,"pmid":"22464332","source_url":"https://pubmed.ncbi.nlm.nih.gov/22464332/","study_design":null,"title":"Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/chemogenetic-locus-coeruleus-activation-restores-reversal-learning-in-29053824","doi":"10.1093/brain/awx232","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"29053824","source_url":"https://pubmed.ncbi.nlm.nih.gov/29053824/","study_design":null,"title":"Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-and-alzheimer-disease-regional-diffusivity-11274543","doi":"10.1148/radiology.219.1.r01ap14101","journal":"Radiology","n_participants":21,"pmid":"11274543","source_url":"https://pubmed.ncbi.nlm.nih.gov/11274543/","study_design":null,"title":"Mild cognitive impairment and Alzheimer disease: regional diffusivity of water","title_match":false,"year":2001},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/baseline-and-longitudinal-grey-matter-changes-in-newly-diagnosed-26173861","doi":"10.1093/brain/awv211","journal":"Brain : a journal of neurology","n_participants":39,"pmid":"26173861","source_url":"https://pubmed.ncbi.nlm.nih.gov/26173861/","study_design":"longitudinal study","title":"Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/olfaction-and-aging-a-mini-review-25968962","doi":"10.1159/000381619","journal":"Gerontology","n_participants":null,"pmid":"25968962","source_url":"https://pubmed.ncbi.nlm.nih.gov/25968962/","study_design":null,"title":"Olfaction and Aging: A Mini-Review","title_match":false,"year":2015},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-due-to-alzheimer-disease-in-the-community-23686697","doi":"10.1002/ana.23931","journal":"Annals of neurology","n_participants":null,"pmid":"23686697","source_url":"https://pubmed.ncbi.nlm.nih.gov/23686697/","study_design":"longitudinal study","title":"Mild cognitive impairment due to Alzheimer disease in the community","title_match":false,"year":2013},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-predictors-of-progression-from-amnestic-mild-20164594","doi":"10.3233/jad-2010-1352","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20164594","source_url":"https://pubmed.ncbi.nlm.nih.gov/20164594/","study_design":null,"title":"Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy","title_match":true,"year":2010},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/early-stages-of-tau-pathology-and-its-associations-with-functional-33725124","doi":"10.1093/brain/awab114","journal":"Brain : a journal of neurology","n_participants":215,"pmid":"33725124","source_url":"https://pubmed.ncbi.nlm.nih.gov/33725124/","study_design":null,"title":"Early stages of tau pathology and its associations with functional connectivity, atrophy and memory","title_match":false,"year":2021},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/longitudinal-course-and-neuropathologic-outcomes-in-original-vs-16894109","doi":"10.1212/01.wnl.0000228231.26111.6e","journal":"Neurology","n_participants":32,"pmid":"16894109","source_url":"https://pubmed.ncbi.nlm.nih.gov/16894109/","study_design":null,"title":"Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI","title_match":false,"year":2006},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/evaluation-of-plasma-abeta-40-and-abeta-42-as-predictors-of-18486992","doi":"10.1016/j.neurobiolaging.2008.03.027","journal":"Neurobiology of aging","n_participants":null,"pmid":"18486992","source_url":"https://pubmed.ncbi.nlm.nih.gov/18486992/","study_design":null,"title":"Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment","title_match":true,"year":2010},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/regional-dynamics-of-amyloid-deposition-in-healthy-elderly-mild-22628162","doi":"10.1093/brain/aws125","journal":"Brain : a journal of neurology","n_participants":32,"pmid":"22628162","source_url":"https://pubmed.ncbi.nlm.nih.gov/22628162/","study_design":"longitudinal study","title":"Regional dynamics of amyloid-\u03b2 deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study","title_match":false,"year":2012},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/involvements-of-the-lipid-peroxidation-product-hne-in-the-20176130","doi":"10.1016/j.bbalip.2010.02.005","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"20176130","source_url":"https://pubmed.ncbi.nlm.nih.gov/20176130/","study_design":null,"title":"Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/neurogranin-as-a-cerebrospinal-fluid-biomarker-for-synaptic-loss-in-26366630","doi":"10.1001/jamaneurol.2015.1867","journal":"JAMA neurology","n_participants":163,"pmid":"26366630","source_url":"https://pubmed.ncbi.nlm.nih.gov/26366630/","study_design":"longitudinal study","title":"Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease","title_match":false,"year":2015},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/amyloid-deposition-in-mild-cognitive-impairment-is-associated-with-25678559","doi":"10.1093/brain/awv007","journal":"Brain : a journal of neurology","n_participants":33,"pmid":"25678559","source_url":"https://pubmed.ncbi.nlm.nih.gov/25678559/","study_design":"cross-sectional","title":"Amyloid-\u03b2 deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression","title_match":true,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/down-regulation-of-trk-but-not-p75ntr-gene-expression-in-single-16539663","doi":"10.1111/j.1471-4159.2006.03764.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"16539663","source_url":"https://pubmed.ncbi.nlm.nih.gov/16539663/","study_design":null,"title":"Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/medial-temporal-lobe-atrophy-and-memory-dysfunction-as-predictors-for-10431775","doi":"10.1007/s004150050387","journal":"Journal of neurology","n_participants":null,"pmid":"10431775","source_url":"https://pubmed.ncbi.nlm.nih.gov/10431775/","study_design":null,"title":"Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment","title_match":false,"year":1999},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/longitudinal-study-of-normal-cognition-in-parkinson-disease-26362285","doi":"10.1212/wnl.0000000000002001","journal":"Neurology","n_participants":141,"pmid":"26362285","source_url":"https://pubmed.ncbi.nlm.nih.gov/26362285/","study_design":"prospective cohort","title":"Longitudinal study of normal cognition in Parkinson disease","title_match":false,"year":2015},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/risk-profiles-for-mild-cognitive-impairment-and-progression-to-18450788","doi":"10.1136/jnnp.2007.136903","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":6892,"pmid":"18450788","source_url":"https://pubmed.ncbi.nlm.nih.gov/18450788/","study_design":null,"title":"Risk profiles for mild cognitive impairment and progression to dementia are gender specific","title_match":true,"year":2008},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/redox-proteomic-identification-of-4-hydroxy-2-nonenal-modified-brain-18325775","doi":"10.1016/j.nbd.2007.12.007","journal":"Neurobiology of disease","n_participants":null,"pmid":"18325775","source_url":"https://pubmed.ncbi.nlm.nih.gov/18325775/","study_design":null,"title":"Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease","title_match":true,"year":2008},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/diffusion-tensor-imaging-in-mild-cognitive-impairment-and-alzheimer-s-18180656","doi":"10.1097/wco.0b013e3282f4594b","journal":"Current opinion in neurology","n_participants":null,"pmid":"18180656","source_url":"https://pubmed.ncbi.nlm.nih.gov/18180656/","study_design":null,"title":"Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review","title_match":false,"year":2008},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/natural-course-of-mild-cognitive-impairment-in-parkinson-disease-a-5-28108638","doi":"10.1212/wnl.0000000000003634","journal":"Neurology","n_participants":178,"pmid":"28108638","source_url":"https://pubmed.ncbi.nlm.nih.gov/28108638/","study_design":null,"title":"Natural course of mild cognitive impairment in Parkinson disease: A 5-year population-based study","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/metabolome-in-progression-to-alzheimer-s-disease-22832349","doi":"10.1038/tp.2011.55","journal":"Translational psychiatry","n_participants":46,"pmid":"22832349","source_url":"https://pubmed.ncbi.nlm.nih.gov/22832349/","study_design":null,"title":"Metabolome in progression to Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/shrinkage-of-the-entorhinal-cortex-over-five-years-predicts-memory-14749440","doi":"10.1523/jneurosci.4166-03.2004","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"14749440","source_url":"https://pubmed.ncbi.nlm.nih.gov/14749440/","study_design":"longitudinal study","title":"Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults","title_match":false,"year":2004},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/metabolic-syndrome-and-the-risk-of-mild-cognitive-impairment-and-26926205","doi":"10.1001/jamaneurol.2015.4899","journal":"JAMA neurology","n_participants":984,"pmid":"26926205","source_url":"https://pubmed.ncbi.nlm.nih.gov/26926205/","study_design":"longitudinal study","title":"Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort","title_match":true,"year":2016},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/incidence-of-dementia-and-cognitive-impairment-not-dementia-in-the-21425187","doi":"10.1002/ana.22362","journal":"Annals of neurology","n_participants":456,"pmid":"21425187","source_url":"https://pubmed.ncbi.nlm.nih.gov/21425187/","study_design":null,"title":"Incidence of dementia and cognitive impairment, not dementia in the United States","title_match":false,"year":2011},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/high-molecular-weight-beta-amyloid-oligomers-are-elevated-in-20339023","doi":"10.1096/fj.09-150359","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":25,"pmid":"20339023","source_url":"https://pubmed.ncbi.nlm.nih.gov/20339023/","study_design":null,"title":"High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients","title_match":false,"year":2010},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/subjective-cognitive-complaints-contribute-to-misdiagnosis-of-mild-25156329","doi":"10.1017/s135561771400068x","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":null,"pmid":"25156329","source_url":"https://pubmed.ncbi.nlm.nih.gov/25156329/","study_design":null,"title":"Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment","title_match":false,"year":2014},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/impaired-long-distance-functional-connectivity-and-weighted-network-23314940","doi":"10.1093/cercor/bhs410","journal":"Cerebral cortex (New York, N.Y. : 1991)","n_participants":18,"pmid":"23314940","source_url":"https://pubmed.ncbi.nlm.nih.gov/23314940/","study_design":null,"title":"Impaired long distance functional connectivity and weighted network architecture in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/neuropsychological-measures-in-normal-individuals-that-predict-17562935","doi":"10.1001/archneur.64.6.862","journal":"Archives of neurology","n_participants":235,"pmid":"17562935","source_url":"https://pubmed.ncbi.nlm.nih.gov/17562935/","study_design":null,"title":"Neuropsychological measures in normal individuals that predict subsequent cognitive decline","title_match":false,"year":2007},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/increased-prongf-levels-in-subjects-with-mild-cognitive-impairment-15217092","doi":"10.1093/jnen/63.6.641","journal":"Journal of neuropathology and experimental neurology","n_participants":20,"pmid":"15217092","source_url":"https://pubmed.ncbi.nlm.nih.gov/15217092/","study_design":null,"title":"Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease","title_match":false,"year":2004},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/association-of-gba-mutations-and-the-e326k-polymorphism-with-motor-27571329","doi":"10.1001/jamaneurol.2016.2245","journal":"JAMA neurology","n_participants":740,"pmid":"27571329","source_url":"https://pubmed.ncbi.nlm.nih.gov/27571329/","study_design":"longitudinal study","title":"Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease","title_match":false,"year":2016},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/sequential-relationships-between-grey-matter-and-white-matter-atrophy-20688814","doi":"10.1093/brain/awq203","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"20688814","source_url":"https://pubmed.ncbi.nlm.nih.gov/20688814/","study_design":"longitudinal study","title":"Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/neuropsychological-decline-in-schizophrenia-from-the-premorbid-to-the-24030246","doi":"10.1176/appi.ajp.2013.12111438","journal":"The American journal of psychiatry","n_participants":1037,"pmid":"24030246","source_url":"https://pubmed.ncbi.nlm.nih.gov/24030246/","study_design":"longitudinal study","title":"Neuropsychological decline in schizophrenia from the premorbid to the postonset period: evidence from a population-representative longitudinal study","title_match":false,"year":2014},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/sex-and-age-differences-in-atrophic-rates-an-adni-study-with-n-1368-20620666","doi":"10.1016/j.neurobiolaging.2010.04.033","journal":"Neurobiology of aging","n_participants":363,"pmid":"20620666","source_url":"https://pubmed.ncbi.nlm.nih.gov/20620666/","study_design":"longitudinal study","title":"Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans","title_match":false,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/promoting-sleep-oscillations-and-their-functional-coupling-by-28637840","doi":"10.1523/jneurosci.0260-17.2017","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"28637840","source_url":"https://pubmed.ncbi.nlm.nih.gov/28637840/","study_design":null,"title":"Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/differential-memory-test-sensitivity-for-diagnosing-amnestic-mild-19353345","doi":"10.1080/13825580902825220","journal":"Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition","n_participants":51,"pmid":"19353345","source_url":"https://pubmed.ncbi.nlm.nih.gov/19353345/","study_design":null,"title":"Differential memory test sensitivity for diagnosing amnestic mild cognitive impairment and predicting conversion to Alzheimer's disease","title_match":true,"year":2009},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/o-glcnac-and-neurodegeneration-biochemical-mechanisms-and-potential-24759912","doi":"10.1039/c4cs00038b","journal":"Chemical Society reviews","n_participants":null,"pmid":"24759912","source_url":"https://pubmed.ncbi.nlm.nih.gov/24759912/","study_design":"longitudinal study","title":"O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/concerted-changes-in-transcripts-in-the-prefrontal-cortex-precede-20889584","doi":"10.1093/brain/awq258","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"20889584","source_url":"https://pubmed.ncbi.nlm.nih.gov/20889584/","study_design":null,"title":"Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/restriction-in-complex-activities-of-daily-living-in-mci-impact-on-16894108","doi":"10.1212/01.wnl.0000228228.70065.f1","journal":"Neurology","n_participants":1517,"pmid":"16894108","source_url":"https://pubmed.ncbi.nlm.nih.gov/16894108/","study_design":"cross-sectional","title":"Restriction in complex activities of daily living in MCI: impact on outcome","title_match":false,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-utility-of-cerebral-blood-flow-as-a-biomarker-of-preclinical-26898552","doi":"10.1007/s10571-015-0261-z","journal":"Cellular and molecular neurobiology","n_participants":null,"pmid":"26898552","source_url":"https://pubmed.ncbi.nlm.nih.gov/26898552/","study_design":null,"title":"The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/effects-of-low-blood-pressure-in-cognitively-impaired-elderly-25730775","doi":"10.1001/jamainternmed.2014.8164","journal":"JAMA internal medicine","n_participants":172,"pmid":"25730775","source_url":"https://pubmed.ncbi.nlm.nih.gov/25730775/","study_design":"cohort study","title":"Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs","title_match":false,"year":2015},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/predicting-alzheimer-s-disease-progression-using-multi-modal-deep-30760848","doi":"10.1038/s41598-018-37769-z","journal":"Scientific reports","n_participants":null,"pmid":"30760848","source_url":"https://pubmed.ncbi.nlm.nih.gov/30760848/","study_design":"cross-sectional","title":"Predicting Alzheimer's disease progression using multi-modal deep learning approach","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/diffusion-imaging-changes-in-grey-matter-in-alzheimer-s-disease-a-26136857","doi":"10.1186/s13195-015-0132-3","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"26136857","source_url":"https://pubmed.ncbi.nlm.nih.gov/26136857/","study_design":null,"title":"Diffusion imaging changes in grey matter in Alzheimer's disease: a potential marker of early neurodegeneration","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/oxidative-dna-damage-in-peripheral-leukocytes-of-mild-cognitive-15708428","doi":"10.1016/j.neurobiolaging.2004.07.016","journal":"Neurobiology of aging","n_participants":null,"pmid":"15708428","source_url":"https://pubmed.ncbi.nlm.nih.gov/15708428/","study_design":null,"title":"Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients","title_match":false,"year":2005},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/tracking-alzheimer-s-disease-17413023","doi":"10.1196/annals.1379.017","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"17413023","source_url":"https://pubmed.ncbi.nlm.nih.gov/17413023/","study_design":null,"title":"Tracking Alzheimer's disease","title_match":false,"year":2007},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/abnormal-salience-network-in-normal-aging-and-in-amnestic-mild-24222384","doi":"10.1002/hbm.22414","journal":"Human brain mapping","n_participants":null,"pmid":"24222384","source_url":"https://pubmed.ncbi.nlm.nih.gov/24222384/","study_design":null,"title":"Abnormal salience network in normal aging and in amnestic mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/hippocampal-tau-pathology-is-related-to-neuroanatomical-connections-19321462","doi":"10.1093/brain/awp059","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"19321462","source_url":"https://pubmed.ncbi.nlm.nih.gov/19321462/","study_design":null,"title":"Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study","title_match":false,"year":2009},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/antioxidant-clinical-trials-in-mild-cognitive-impairment-and-22019723","doi":"10.1016/j.bbadis.2011.10.006","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"22019723","source_url":"https://pubmed.ncbi.nlm.nih.gov/22019723/","study_design":null,"title":"Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/elevated-protein-bound-levels-of-the-lipid-peroxidation-product-4-16413966","doi":"10.1016/j.neulet.2005.12.017","journal":"Neuroscience letters","n_participants":null,"pmid":"16413966","source_url":"https://pubmed.ncbi.nlm.nih.gov/16413966/","study_design":null,"title":"Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment","title_match":false,"year":2006},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/magnetic-resonance-spectroscopy-in-ad-11261442","doi":"10.1212/wnl.56.5.592","journal":"Neurology","n_participants":null,"pmid":"11261442","source_url":"https://pubmed.ncbi.nlm.nih.gov/11261442/","study_design":null,"title":"Magnetic resonance spectroscopy in AD","title_match":false,"year":2001},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/altered-gut-microbial-metabolites-in-amnestic-mild-cognitive-33466861","doi":"10.3390/nu13010228","journal":"Nutrients","n_participants":77,"pmid":"33466861","source_url":"https://pubmed.ncbi.nlm.nih.gov/33466861/","study_design":null,"title":"Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Signals in Host-Microbe Interplay","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/nonamnestic-mild-cognitive-impairment-progresses-to-dementia-with-24212390","doi":"10.1212/01.wnl.0000436942.55281.47","journal":"Neurology","n_participants":337,"pmid":"24212390","source_url":"https://pubmed.ncbi.nlm.nih.gov/24212390/","study_design":null,"title":"Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies","title_match":true,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/predicting-future-clinical-changes-of-mci-patients-using-longitudinal-22457741","doi":"10.1371/journal.pone.0033182","journal":"PloS one","n_participants":null,"pmid":"22457741","source_url":"https://pubmed.ncbi.nlm.nih.gov/22457741/","study_design":"longitudinal study","title":"Predicting future clinical changes of MCI patients using longitudinal and multimodal biomarkers","title_match":false,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/accelerated-progression-from-mild-cognitive-impairment-to-dementia-in-20713684","doi":"10.2337/db10-0539","journal":"Diabetes","n_participants":302,"pmid":"20713684","source_url":"https://pubmed.ncbi.nlm.nih.gov/20713684/","study_design":null,"title":"Accelerated progression from mild cognitive impairment to dementia in people with diabetes","title_match":true,"year":2010},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/early-diagnosis-of-alzheimer-s-disease-is-mci-too-late-19689230","doi":"10.2174/156720509788929237","journal":"Current Alzheimer research","n_participants":null,"pmid":"19689230","source_url":"https://pubmed.ncbi.nlm.nih.gov/19689230/","study_design":null,"title":"Early diagnosis of Alzheimer's disease: is MCI too late?","title_match":false,"year":2009},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/elevated-levels-of-3-nitrotyrosine-in-brain-from-subjects-with-17395167","doi":"10.1016/j.brainres.2007.02.084","journal":"Brain research","n_participants":null,"pmid":"17395167","source_url":"https://pubmed.ncbi.nlm.nih.gov/17395167/","study_design":null,"title":"Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease","title_match":true,"year":2007},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/estimating-alzheimer-s-disease-progression-rates-from-normal-29357799","doi":"10.2174/1567205015666180119092427","journal":"Current Alzheimer research","n_participants":18103,"pmid":"29357799","source_url":"https://pubmed.ncbi.nlm.nih.gov/29357799/","study_design":"longitudinal study","title":"Estimating Alzheimer's Disease Progression Rates from Normal Cognition Through Mild Cognitive Impairment and Stages of Dementia","title_match":true,"year":2018},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/subjective-cognitive-concerns-and-neuropsychiatric-predictors-of-24698445","doi":"10.1016/j.jagp.2014.02.007","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"24698445","source_url":"https://pubmed.ncbi.nlm.nih.gov/24698445/","study_design":"longitudinal study","title":"Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/prediction-of-alzheimer-s-disease-in-subjects-with-mild-cognitive-23036450","doi":"10.1016/j.neuroimage.2012.09.058","journal":"NeuroImage","n_participants":null,"pmid":"23036450","source_url":"https://pubmed.ncbi.nlm.nih.gov/23036450/","study_design":null,"title":"Prediction of Alzheimer's disease in subjects with mild cognitive impairment from the ADNI cohort using patterns of cortical thinning","title_match":false,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/regionally-specific-diffusion-tensor-imaging-in-mild-cognitive-19457371","doi":"10.1016/j.neuroimage.2009.01.054","journal":"NeuroImage","n_participants":75,"pmid":"19457371","source_url":"https://pubmed.ncbi.nlm.nih.gov/19457371/","study_design":"cross-sectional","title":"Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/hmgb1-and-thrombin-mediate-the-blood-brain-barrier-dysfunction-acting-27553758","doi":"10.1186/s12974-016-0670-z","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"27553758","source_url":"https://pubmed.ncbi.nlm.nih.gov/27553758/","study_design":null,"title":"HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/effects-of-hypoperfusion-in-alzheimer-s-disease-21971457","doi":"10.3233/jad-2011-0010","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21971457","source_url":"https://pubmed.ncbi.nlm.nih.gov/21971457/","study_design":null,"title":"Effects of hypoperfusion in Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/visuospatial-memory-in-healthy-elderly-ad-and-mci-a-review-20021398","doi":"10.2174/1874609810902010043","journal":"Current aging science","n_participants":null,"pmid":"20021398","source_url":"https://pubmed.ncbi.nlm.nih.gov/20021398/","study_design":null,"title":"Visuospatial memory in healthy elderly, AD and MCI: a review","title_match":false,"year":2009},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/heterogeneity-of-brain-glucose-metabolism-in-mild-cognitive-16286547","doi":"10.1001/archneur.62.11.1728","journal":"Archives of neurology","n_participants":null,"pmid":"16286547","source_url":"https://pubmed.ncbi.nlm.nih.gov/16286547/","study_design":null,"title":"Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease","title_match":true,"year":2005},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/cognitive-status-correlates-with-white-matter-alteration-in-parkinson-21495116","doi":"10.1002/hbm.21245","journal":"Human brain mapping","n_participants":32,"pmid":"21495116","source_url":"https://pubmed.ncbi.nlm.nih.gov/21495116/","study_design":null,"title":"Cognitive status correlates with white matter alteration in Parkinson's disease","title_match":false,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/oxidatively-modified-proteins-in-alzheimer-s-disease-ad-mild-19288120","doi":"10.1007/s00401-009-0517-0","journal":"Acta neuropathologica","n_participants":null,"pmid":"19288120","source_url":"https://pubmed.ncbi.nlm.nih.gov/19288120/","study_design":null,"title":"Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis","title_match":false,"year":2009},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/fornix-integrity-and-hippocampal-volume-predict-memory-decline-and-22404852","doi":"10.1016/j.jalz.2011.05.2416","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"22404852","source_url":"https://pubmed.ncbi.nlm.nih.gov/22404852/","study_design":"cross-sectional","title":"Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/metabolic-abnormalities-associated-with-mild-cognitive-impairment-in-18367705","doi":"10.1212/01.wnl.0000304050.05332.9c","journal":"Neurology","n_participants":18,"pmid":"18367705","source_url":"https://pubmed.ncbi.nlm.nih.gov/18367705/","study_design":null,"title":"Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease","title_match":false,"year":2008},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/inflammatory-biomarkers-in-alzheimer-s-disease-plasma-31047856","doi":"10.1016/j.jalz.2019.03.007","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31047856","source_url":"https://pubmed.ncbi.nlm.nih.gov/31047856/","study_design":null,"title":"Inflammatory biomarkers in Alzheimer's disease plasma","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/initial-cognitive-decline-is-associated-with-cortical-thinning-in-24808018","doi":"10.1212/wnl.0000000000000483","journal":"Neurology","n_participants":null,"pmid":"24808018","source_url":"https://pubmed.ncbi.nlm.nih.gov/24808018/","study_design":null,"title":"Initial cognitive decline is associated with cortical thinning in early Parkinson disease","title_match":false,"year":2014},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/brain-mechanisms-underlying-neuropsychiatric-symptoms-in-alzheimer-s-34099005","doi":"10.1186/s13024-021-00456-1","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"34099005","source_url":"https://pubmed.ncbi.nlm.nih.gov/34099005/","study_design":null,"title":"Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: a systematic review of symptom-general and -specific lesion patterns","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/oxidative-damage-in-mild-cognitive-impairment-and-early-alzheimer-s-17510979","doi":"10.1002/jnr.21346","journal":"Journal of neuroscience research","n_participants":null,"pmid":"17510979","source_url":"https://pubmed.ncbi.nlm.nih.gov/17510979/","study_design":null,"title":"Oxidative damage in mild cognitive impairment and early Alzheimer's disease","title_match":false,"year":2007},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/cognitive-and-memory-training-in-adults-at-risk-of-dementia-a-21942932","doi":"10.1186/1471-2318-11-55","journal":"BMC geriatrics","n_participants":305,"pmid":"21942932","source_url":"https://pubmed.ncbi.nlm.nih.gov/21942932/","study_design":"systematic review","title":"Cognitive and memory training in adults at risk of dementia: a systematic review","title_match":false,"year":2011},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/current-epidemiology-of-mild-cognitive-impairment-and-other-16085779","doi":"10.1176/appi.ajgp.13.8.633","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"16085779","source_url":"https://pubmed.ncbi.nlm.nih.gov/16085779/","study_design":null,"title":"Current epidemiology of mild cognitive impairment and other predementia syndromes","title_match":false,"year":2005},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neuropathologic-alterations-in-mild-cognitive-impairment-a-review-20061641","doi":"10.3233/jad-2010-1220","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20061641","source_url":"https://pubmed.ncbi.nlm.nih.gov/20061641/","study_design":null,"title":"Neuropathologic alterations in mild cognitive impairment: a review","title_match":false,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-a-systematic-review-17851192","doi":"10.3233/jad-2007-12104","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"17851192","source_url":"https://pubmed.ncbi.nlm.nih.gov/17851192/","study_design":null,"title":"Mild cognitive impairment: a systematic review","title_match":false,"year":2007},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/24s-hydroxycholesterol-in-cerebrospinal-fluid-is-elevated-in-early-11755458","doi":"10.1016/s0022-3956(01)00050-4","journal":"Journal of psychiatric research","n_participants":32,"pmid":"11755458","source_url":"https://pubmed.ncbi.nlm.nih.gov/11755458/","study_design":null,"title":"24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia","title_match":false,"year":2002},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/measures-of-resting-state-eeg-rhythms-for-clinical-trials-in-33860614","doi":"10.1002/alz.12311","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"33860614","source_url":"https://pubmed.ncbi.nlm.nih.gov/33860614/","study_design":null,"title":"Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel","title_match":false,"year":2021},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/optical-coherence-tomography-in-alzheimer-s-disease-a-meta-analysis-26252902","doi":"10.1371/journal.pone.0134750","journal":"PloS one","n_participants":380,"pmid":"26252902","source_url":"https://pubmed.ncbi.nlm.nih.gov/26252902/","study_design":"meta-analysis","title":"Optical Coherence Tomography in Alzheimer's Disease: A Meta-Analysis","title_match":false,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/automated-detection-of-brain-atrophy-patterns-based-on-mri-for-the-19961938","doi":"10.1016/j.neuroimage.2009.11.046","journal":"NeuroImage","n_participants":null,"pmid":"19961938","source_url":"https://pubmed.ncbi.nlm.nih.gov/19961938/","study_design":null,"title":"Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cognitive-assessment-tools-for-mild-cognitive-impairment-screening-31414193","doi":"10.1007/s00415-019-09506-7","journal":"Journal of neurology","n_participants":null,"pmid":"31414193","source_url":"https://pubmed.ncbi.nlm.nih.gov/31414193/","study_design":null,"title":"Cognitive assessment tools for mild cognitive impairment screening","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/colocalization-of-cerebral-iron-with-amyloid-beta-in-mild-cognitive-27748454","doi":"10.1038/srep35514","journal":"Scientific reports","n_participants":null,"pmid":"27748454","source_url":"https://pubmed.ncbi.nlm.nih.gov/27748454/","study_design":null,"title":"Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/proteomic-identification-of-hne-bound-proteins-in-early-alzheimer-19374891","doi":"10.1016/j.brainres.2009.04.009","journal":"Brain research","n_participants":null,"pmid":"19374891","source_url":"https://pubmed.ncbi.nlm.nih.gov/19374891/","study_design":null,"title":"Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD","title_match":false,"year":2009},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/csf-tau-protein-phosphorylated-at-threonine-231-correlates-with-12196665","doi":"10.1212/wnl.59.4.627","journal":"Neurology","n_participants":77,"pmid":"12196665","source_url":"https://pubmed.ncbi.nlm.nih.gov/12196665/","study_design":"longitudinal study","title":"CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects","title_match":false,"year":2002},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/prevalence-of-mild-cognitive-impairment-in-an-urban-community-in-24613707","doi":"10.1016/j.jalz.2013.11.002","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"24613707","source_url":"https://pubmed.ncbi.nlm.nih.gov/24613707/","study_design":null,"title":"Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai Aging Study","title_match":false,"year":2015},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/fifteen-years-of-the-australian-imaging-biomarkers-and-lifestyle-aibl-34368630","doi":"10.3233/adr-210005","journal":"Journal of Alzheimer's disease reports","n_participants":1112,"pmid":"34368630","source_url":"https://pubmed.ncbi.nlm.nih.gov/34368630/","study_design":"cohort study","title":"Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/prediction-of-dementia-in-mci-patients-based-on-core-diagnostic-23390179","doi":"10.1212/wnl.0b013e3182872830","journal":"Neurology","n_participants":73,"pmid":"23390179","source_url":"https://pubmed.ncbi.nlm.nih.gov/23390179/","study_design":null,"title":"Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-a42-is-the-best-predictor-of-clinical-progression-23232269","doi":"10.1016/j.jalz.2012.08.004","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":127,"pmid":"23232269","source_url":"https://pubmed.ncbi.nlm.nih.gov/23232269/","study_design":null,"title":"Cerebrospinal fluid A\u03b242 is the best predictor of clinical progression in patients with subjective complaints","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/subjective-memory-complaints-and-awareness-of-memory-functioning-in-19684399","doi":"10.1159/000234911","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"19684399","source_url":"https://pubmed.ncbi.nlm.nih.gov/19684399/","study_design":null,"title":"Subjective memory complaints and awareness of memory functioning in mild cognitive impairment: a systematic review","title_match":false,"year":2009},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/neuronal-hypertrophy-in-asymptomatic-alzheimer-disease-18520776","doi":"10.1097/nen.0b013e3181772794","journal":"Journal of neuropathology and experimental neurology","n_participants":15,"pmid":"18520776","source_url":"https://pubmed.ncbi.nlm.nih.gov/18520776/","study_design":"longitudinal study","title":"Neuronal hypertrophy in asymptomatic Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/heterogeneity-of-neuroanatomical-patterns-in-prodromal-alzheimer-s-28003242","doi":"10.1093/brain/aww319","journal":"Brain : a journal of neurology","n_participants":530,"pmid":"28003242","source_url":"https://pubmed.ncbi.nlm.nih.gov/28003242/","study_design":"longitudinal study","title":"Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers","title_match":false,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/sulcal-morphology-changes-and-their-relationship-with-cortical-18691657","doi":"10.1016/j.neuroimage.2008.07.016","journal":"NeuroImage","n_participants":null,"pmid":"18691657","source_url":"https://pubmed.ncbi.nlm.nih.gov/18691657/","study_design":null,"title":"Sulcal morphology changes and their relationship with cortical thickness and gyral white matter volume in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/can-ketones-help-rescue-brain-fuel-supply-in-later-life-implications-27458340","doi":"10.3389/fnmol.2016.00053","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"27458340","source_url":"https://pubmed.ncbi.nlm.nih.gov/27458340/","study_design":null,"title":"Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-in-the-general-population-occurrence-and-18591580","doi":"10.1097/jgp.0b013e3181753a64","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"18591580","source_url":"https://pubmed.ncbi.nlm.nih.gov/18591580/","study_design":null,"title":"Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease","title_match":true,"year":2008},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/circadian-disturbances-in-alzheimer-s-disease-progression-a-34179863","doi":"10.1016/s2666-7568(20)30015-5","journal":"The lancet. Healthy longevity","n_participants":null,"pmid":"34179863","source_url":"https://pubmed.ncbi.nlm.nih.gov/34179863/","study_design":"cohort study","title":"Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/reduction-of-cortical-trka-but-not-p75-ntr-protein-in-early-stage-15455399","doi":"10.1002/ana.20233","journal":"Annals of neurology","n_participants":null,"pmid":"15455399","source_url":"https://pubmed.ncbi.nlm.nih.gov/15455399/","study_design":null,"title":"Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease","title_match":false,"year":2004},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-and-abeta42-as-predictors-of-development-of-10505638","doi":"10.1016/s0304-3940(99)00617-5","journal":"Neuroscience letters","n_participants":15,"pmid":"10505638","source_url":"https://pubmed.ncbi.nlm.nih.gov/10505638/","study_design":null,"title":"Cerebrospinal fluid tau and Abeta42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment","title_match":false,"year":1999},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-proteins-predict-conversion-to-dementia-from-prodromal-disease-25012867","doi":"10.1016/j.jalz.2014.05.1749","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1148,"pmid":"25012867","source_url":"https://pubmed.ncbi.nlm.nih.gov/25012867/","study_design":null,"title":"Plasma proteins predict conversion to dementia from prodromal disease","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/using-virtual-reality-to-characterize-episodic-memory-profiles-in-22261400","doi":"10.1016/j.neuropsychologia.2011.12.013","journal":"Neuropsychologia","n_participants":null,"pmid":"22261400","source_url":"https://pubmed.ncbi.nlm.nih.gov/22261400/","study_design":null,"title":"Using virtual reality to characterize episodic memory profiles in amnestic mild cognitive impairment and Alzheimer's disease: influence of active and passive encoding","title_match":false,"year":2012},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/contribution-of-hyperammonemia-and-inflammatory-factors-to-cognitive-22072427","doi":"10.1007/s11011-011-9269-3","journal":"Metabolic brain disease","n_participants":null,"pmid":"22072427","source_url":"https://pubmed.ncbi.nlm.nih.gov/22072427/","study_design":null,"title":"Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy","title_match":false,"year":2012},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/a-ketogenic-drink-improves-cognition-in-mild-cognitive-impairment-33103819","doi":"10.1002/alz.12206","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":39,"pmid":"33103819","source_url":"https://pubmed.ncbi.nlm.nih.gov/33103819/","study_design":null,"title":"A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT","title_match":false,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/plasma-microrna-biomarkers-for-detection-of-mild-cognitive-impairment-23001356","doi":"10.18632/aging.100486","journal":"Aging","n_participants":null,"pmid":"23001356","source_url":"https://pubmed.ncbi.nlm.nih.gov/23001356/","study_design":"longitudinal study","title":"Plasma microRNA biomarkers for detection of mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/tau-conformational-changes-correspond-to-impairments-of-episodic-12429193","doi":"10.1006/exnr.2002.8014","journal":"Experimental neurology","n_participants":null,"pmid":"12429193","source_url":"https://pubmed.ncbi.nlm.nih.gov/12429193/","study_design":null,"title":"Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2002},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/handgrip-strength-as-a-means-of-monitoring-progression-of-cognitive-28189666","doi":"10.1016/j.arr.2017.01.004","journal":"Ageing research reviews","n_participants":null,"pmid":"28189666","source_url":"https://pubmed.ncbi.nlm.nih.gov/28189666/","study_design":"longitudinal study","title":"Handgrip strength as a means of monitoring progression of cognitive decline - A scoping review","title_match":false,"year":2017},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/factors-affecting-a-plasma-levels-and-their-utility-as-biomarkers-in-21805181","doi":"10.1007/s00401-011-0861-8","journal":"Acta neuropathologica","n_participants":715,"pmid":"21805181","source_url":"https://pubmed.ncbi.nlm.nih.gov/21805181/","study_design":"longitudinal study","title":"Factors affecting A\u03b2 plasma levels and their utility as biomarkers in ADNI","title_match":false,"year":2011},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/tau-pet-and-in-vivo-braak-staging-as-prognostic-markers-of-future-34384484","doi":"10.1186/s13195-021-00880-x","journal":"Alzheimer's research & therapy","n_participants":396,"pmid":"34384484","source_url":"https://pubmed.ncbi.nlm.nih.gov/34384484/","study_design":"longitudinal study","title":"Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/preventive-and-therapeutic-strategies-in-alzheimer-s-disease-focus-on-32486897","doi":"10.1089/ars.2020.8134","journal":"Antioxidants & redox signaling","n_participants":null,"pmid":"32486897","source_url":"https://pubmed.ncbi.nlm.nih.gov/32486897/","study_design":null,"title":"Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis","title_match":false,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-are-associated-with-progression-from-mild-17700021","doi":"10.1159/000107100","journal":"Dementia and geriatric cognitive disorders","n_participants":39,"pmid":"17700021","source_url":"https://pubmed.ncbi.nlm.nih.gov/17700021/","study_design":null,"title":"Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2007},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neutrophil-hyperactivation-correlates-with-alzheimer-s-disease-29369398","doi":"10.1002/ana.25159","journal":"Annals of neurology","n_participants":42,"pmid":"29369398","source_url":"https://pubmed.ncbi.nlm.nih.gov/29369398/","study_design":null,"title":"Neutrophil hyperactivation correlates with Alzheimer's disease progression","title_match":false,"year":2018},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/impact-of-ssri-therapy-on-risk-of-conversion-from-mild-cognitive-29179578","doi":"10.1176/appi.ajp.2017.17040404","journal":"The American journal of psychiatry","n_participants":null,"pmid":"29179578","source_url":"https://pubmed.ncbi.nlm.nih.gov/29179578/","study_design":"longitudinal study","title":"Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer's Dementia in Individuals With Previous Depression","title_match":true,"year":2018},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/brain-microstructure-reveals-early-abnormalities-more-than-two-years-23365250","doi":"10.1523/jneurosci.4437-12.2013","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"23365250","source_url":"https://pubmed.ncbi.nlm.nih.gov/23365250/","study_design":"longitudinal study","title":"Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/longitudinal-deficits-to-attention-executive-and-working-memory-in-21381828","doi":"10.1037/a0021134","journal":"Neuropsychology","n_participants":null,"pmid":"21381828","source_url":"https://pubmed.ncbi.nlm.nih.gov/21381828/","study_design":"longitudinal study","title":"Longitudinal deficits to attention, executive, and working memory in subtypes of mild cognitive impairment","title_match":false,"year":2011},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/evidence-of-demyelination-in-mild-cognitive-impairment-and-dementia-29679574","doi":"10.1016/j.jalz.2018.03.007","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"29679574","source_url":"https://pubmed.ncbi.nlm.nih.gov/29679574/","study_design":null,"title":"Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content","title_match":false,"year":2018},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/fluid-biomarkers-in-alzheimer-s-disease-current-concepts-23800368","doi":"10.1186/1750-1326-8-20","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"23800368","source_url":"https://pubmed.ncbi.nlm.nih.gov/23800368/","study_design":"cross-sectional","title":"Fluid biomarkers in Alzheimer's disease - current concepts","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/late-life-depression-as-a-risk-factor-for-mild-cognitive-impairment-22543846","doi":"10.3233/jad-2012-111922","journal":"Journal of Alzheimer's disease : JAD","n_participants":5607,"pmid":"22543846","source_url":"https://pubmed.ncbi.nlm.nih.gov/22543846/","study_design":null,"title":"Late-life depression as a risk factor for mild cognitive impairment or Alzheimer's disease in 30 US Alzheimer's disease centers","title_match":false,"year":2012},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cerebral-blood-flow-measured-by-arterial-spin-labeling-mri-at-resting-27908711","doi":"10.1016/j.neubiorev.2016.11.023","journal":"Neuroscience and biobehavioral reviews","n_participants":null,"pmid":"27908711","source_url":"https://pubmed.ncbi.nlm.nih.gov/27908711/","study_design":null,"title":"Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/retinal-alterations-in-mild-cognitive-impairment-and-alzheimer-s-24846203","doi":"10.1007/s00415-014-7374-z","journal":"Journal of neurology","n_participants":18,"pmid":"24846203","source_url":"https://pubmed.ncbi.nlm.nih.gov/24846203/","study_design":"cross-sectional","title":"Retinal alterations in mild cognitive impairment and Alzheimer's disease: an optical coherence tomography study","title_match":false,"year":2014},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/decreased-levels-of-psd95-and-two-associated-proteins-and-increased-19774677","doi":"10.1002/jnr.22227","journal":"Journal of neuroscience research","n_participants":null,"pmid":"19774677","source_url":"https://pubmed.ncbi.nlm.nih.gov/19774677/","study_design":null,"title":"Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/biomarkers-of-lipid-peroxidation-in-alzheimer-disease-ad-an-update-25895140","doi":"10.1007/s00204-015-1517-6","journal":"Archives of toxicology","n_participants":null,"pmid":"25895140","source_url":"https://pubmed.ncbi.nlm.nih.gov/25895140/","study_design":null,"title":"Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update","title_match":false,"year":2015},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/docosahexaenoic-acid-concentrated-fish-oil-supplementation-in-22932777","doi":"10.1007/s00213-012-2848-0","journal":"Psychopharmacology","n_participants":18,"pmid":"22932777","source_url":"https://pubmed.ncbi.nlm.nih.gov/22932777/","study_design":null,"title":"Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/sleep-disorders-in-aging-and-dementia-20191256","doi":"10.1007/s12603-010-0052-7","journal":"The journal of nutrition, health & aging","n_participants":null,"pmid":"20191256","source_url":"https://pubmed.ncbi.nlm.nih.gov/20191256/","study_design":null,"title":"Sleep disorders in aging and dementia","title_match":false,"year":2010},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/two-year-progression-from-mild-cognitive-impairment-to-dementia-to-18662209","doi":"10.1111/j.1532-5415.2008.01820.x","journal":"Journal of the American Geriatrics Society","n_participants":2640,"pmid":"18662209","source_url":"https://pubmed.ncbi.nlm.nih.gov/18662209/","study_design":"cohort study","title":"Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?","title_match":true,"year":2008},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-directions-for-future-research-12939414","doi":"10.1212/01.wnl.0000080366.90234.7f","journal":"Neurology","n_participants":null,"pmid":"12939414","source_url":"https://pubmed.ncbi.nlm.nih.gov/12939414/","study_design":null,"title":"Mild cognitive impairment: directions for future research","title_match":false,"year":2003},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/applications-of-amyloid-tau-and-neuroinflammation-pet-imaging-to-31520513","doi":"10.1002/hbm.24782","journal":"Human brain mapping","n_participants":null,"pmid":"31520513","source_url":"https://pubmed.ncbi.nlm.nih.gov/31520513/","study_design":null,"title":"Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-a-beta42-is-increased-early-in-sporadic-alzheimer-10211475","doi":"10.1002/1531-8249(199904)45:4<504::aid-ana12>3.0.co;2-9","journal":"Annals of neurology","n_participants":null,"pmid":"10211475","source_url":"https://pubmed.ncbi.nlm.nih.gov/10211475/","study_design":null,"title":"Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression","title_match":false,"year":1999},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/oxidative-stress-involving-changes-in-nrf2-and-er-stress-in-early-25857617","doi":"10.1016/j.bbadis.2015.03.015","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"25857617","source_url":"https://pubmed.ncbi.nlm.nih.gov/25857617/","study_design":null,"title":"Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/longitudinal-1h-mrs-changes-in-mild-cognitive-impairment-and-16860440","doi":"10.1016/j.neurobiolaging.2006.06.018","journal":"Neurobiology of aging","n_participants":null,"pmid":"16860440","source_url":"https://pubmed.ncbi.nlm.nih.gov/16860440/","study_design":"longitudinal study","title":"Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2007},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-redox-dysregulation-as-a-common-denominator-for-22122400","doi":"10.1089/ars.2011.4082","journal":"Antioxidants & redox signaling","n_participants":null,"pmid":"22122400","source_url":"https://pubmed.ncbi.nlm.nih.gov/22122400/","study_design":null,"title":"Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms","title_match":false,"year":2012},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/optical-coherence-tomography-in-alzheimer-s-disease-and-other-29312125","doi":"10.3389/fneur.2017.00701","journal":"Frontiers in neurology","n_participants":null,"pmid":"29312125","source_url":"https://pubmed.ncbi.nlm.nih.gov/29312125/","study_design":"cross-sectional","title":"Optical Coherence Tomography in Alzheimer's Disease and Other Neurodegenerative Diseases","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neuropsychological-predictors-of-conversion-from-mild-cognitive-24002185","doi":"10.3233/jad-130881","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"24002185","source_url":"https://pubmed.ncbi.nlm.nih.gov/24002185/","study_design":null,"title":"Neuropsychological predictors of conversion from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/multifunctional-roles-of-enolase-in-alzheimer-s-disease-brain-beyond-19780894","doi":"10.1111/j.1471-4159.2009.06397.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"19780894","source_url":"https://pubmed.ncbi.nlm.nih.gov/19780894/","study_design":null,"title":"Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism","title_match":false,"year":2009},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/rates-of-progression-in-mild-cognitive-impairment-and-early-alzheimer-12370458","doi":"10.1212/wnl.59.7.1034","journal":"Neurology","n_participants":289,"pmid":"12370458","source_url":"https://pubmed.ncbi.nlm.nih.gov/12370458/","study_design":"longitudinal study","title":"Rates of progression in mild cognitive impairment and early Alzheimer's disease","title_match":true,"year":2002},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/integrative-eeg-biomarkers-predict-progression-to-alzheimer-s-disease-24106478","doi":"10.3389/fnagi.2013.00058","journal":"Frontiers in aging neuroscience","n_participants":86,"pmid":"24106478","source_url":"https://pubmed.ncbi.nlm.nih.gov/24106478/","study_design":null,"title":"Integrative EEG biomarkers predict progression to Alzheimer's disease at the MCI stage","title_match":true,"year":2013},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/homogeneity-and-heterogeneity-in-mild-cognitive-impairment-and-12876147","doi":"10.1093/brain/awg236","journal":"Brain : a journal of neurology","n_participants":55,"pmid":"12876147","source_url":"https://pubmed.ncbi.nlm.nih.gov/12876147/","study_design":"cross-sectional","title":"Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer's disease: a cross-sectional and longitudinal study of 55 cases","title_match":false,"year":2003},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/human-neural-cell-type-specific-extracellular-vesicle-proteome-35029059","doi":"10.1002/jev2.12183","journal":"Journal of extracellular vesicles","n_participants":null,"pmid":"35029059","source_url":"https://pubmed.ncbi.nlm.nih.gov/35029059/","study_design":null,"title":"Human neural cell type-specific\u00a0extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain","title_match":false,"year":2022},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/therapeutically-relevant-structural-and-functional-mechanisms-27001615","doi":"10.1038/mp.2016.19","journal":"Molecular psychiatry","n_participants":100,"pmid":"27001615","source_url":"https://pubmed.ncbi.nlm.nih.gov/27001615/","study_design":null,"title":"Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise","title_match":false,"year":2016},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/inflammatory-proteins-in-plasma-are-associated-with-severity-of-23762274","doi":"10.1371/journal.pone.0064971","journal":"PloS one","n_participants":350,"pmid":"23762274","source_url":"https://pubmed.ncbi.nlm.nih.gov/23762274/","study_design":"longitudinal study","title":"Inflammatory proteins in plasma are associated with severity of Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/abnormal-insula-functional-network-is-associated-with-episodic-memory-22776459","doi":"10.1016/j.neuroimage.2012.06.062","journal":"NeuroImage","n_participants":null,"pmid":"22776459","source_url":"https://pubmed.ncbi.nlm.nih.gov/22776459/","study_design":null,"title":"Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/retinal-pathological-features-and-proteome-signatures-of-alzheimer-s-36773106","doi":"10.1007/s00401-023-02548-2","journal":"Acta neuropathologica","n_participants":null,"pmid":"36773106","source_url":"https://pubmed.ncbi.nlm.nih.gov/36773106/","study_design":null,"title":"Retinal pathological features and proteome signatures of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/predicting-progression-from-mild-cognitive-impairment-to-alzheimer-s-26901338","doi":"10.1371/journal.pone.0138866","journal":"PloS one","n_participants":139,"pmid":"26901338","source_url":"https://pubmed.ncbi.nlm.nih.gov/26901338/","study_design":null,"title":"Predicting Progression from Mild Cognitive Impairment to Alzheimer's Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification","title_match":true,"year":2016},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/hippocampal-plasticity-during-the-progression-of-alzheimer-s-disease-25772787","doi":"10.1016/j.neuroscience.2015.03.006","journal":"Neuroscience","n_participants":null,"pmid":"25772787","source_url":"https://pubmed.ncbi.nlm.nih.gov/25772787/","study_design":null,"title":"Hippocampal plasticity during the progression of Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/clinical-aspects-of-melatonin-intervention-in-alzheimer-s-disease-21358972","doi":"10.2174/157015910792246209","journal":"Current neuropharmacology","n_participants":null,"pmid":"21358972","source_url":"https://pubmed.ncbi.nlm.nih.gov/21358972/","study_design":null,"title":"Clinical aspects of melatonin intervention in Alzheimer's disease progression","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/prevalence-of-mild-cognitive-impairment-by-multiple-classifications-20220597","doi":"10.1097/jgp.0b013e3181cdee4f","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":2036,"pmid":"20220597","source_url":"https://pubmed.ncbi.nlm.nih.gov/20220597/","study_design":"cross-sectional","title":"Prevalence of mild cognitive impairment by multiple classifications: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) project","title_match":false,"year":2010},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/development-and-evaluation-of-a-multiplexed-mass-spectrometry-based-25676562","doi":"10.1002/prca.201400178","journal":"Proteomics. Clinical applications","n_participants":null,"pmid":"25676562","source_url":"https://pubmed.ncbi.nlm.nih.gov/25676562/","study_design":null,"title":"Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-european-multicentre-pet-study-of-fibrillar-amyloid-in-alzheimer-s-22961445","doi":"10.1007/s00259-012-2237-2","journal":"European journal of nuclear medicine and molecular imaging","n_participants":97,"pmid":"22961445","source_url":"https://pubmed.ncbi.nlm.nih.gov/22961445/","study_design":null,"title":"A European multicentre PET study of fibrillar amyloid in Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-neuroimaging-initiative-a-one-year-follow-up-19280686","doi":"10.1016/j.neuroimage.2009.01.004","journal":"NeuroImage","n_participants":20,"pmid":"19280686","source_url":"https://pubmed.ncbi.nlm.nih.gov/19280686/","study_design":"longitudinal study","title":"Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition","title_match":false,"year":2009},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/structural-magnetic-resonance-imaging-for-the-early-diagnosis-of-32119112","doi":"10.1002/14651858.cd009628.pub2","journal":"The Cochrane database of systematic reviews","n_participants":33,"pmid":"32119112","source_url":"https://pubmed.ncbi.nlm.nih.gov/32119112/","study_design":"cohort study","title":"Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment","title_match":false,"year":2020},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/prevalence-and-risk-of-progression-of-preclinical-alzheimer-s-disease-30646955","doi":"10.1186/s13195-018-0459-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"30646955","source_url":"https://pubmed.ncbi.nlm.nih.gov/30646955/","study_design":"cross-sectional","title":"Prevalence and risk of progression of preclinical Alzheimer's disease stages: a systematic review and meta-analysis","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/adcoms-a-composite-clinical-outcome-for-prodromal-alzheimer-s-disease-27010616","doi":"10.1136/jnnp-2015-312383","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"27010616","source_url":"https://pubmed.ncbi.nlm.nih.gov/27010616/","study_design":"longitudinal study","title":"ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials","title_match":false,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/magnetic-resonance-imaging-biomarkers-for-the-early-diagnosis-of-26388719","doi":"10.3389/fnins.2015.00307","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"26388719","source_url":"https://pubmed.ncbi.nlm.nih.gov/26388719/","study_design":null,"title":"Magnetic resonance imaging biomarkers for the early diagnosis of Alzheimer's disease: a machine learning approach","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/oxidative-stress-in-alzheimer-disease-and-mild-cognitive-impairment-26126631","doi":"10.1007/s00204-015-1556-z","journal":"Archives of toxicology","n_participants":null,"pmid":"26126631","source_url":"https://pubmed.ncbi.nlm.nih.gov/26126631/","study_design":null,"title":"Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics","title_match":false,"year":2015},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-ceramides-are-altered-in-mild-cognitive-impairment-and-predict-20813340","doi":"10.1016/j.jalz.2010.03.014","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":25,"pmid":"20813340","source_url":"https://pubmed.ncbi.nlm.nih.gov/20813340/","study_design":"cross-sectional","title":"Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-current-research-and-clinical-implications-17226738","doi":"10.1055/s-2006-956752","journal":"Seminars in neurology","n_participants":null,"pmid":"17226738","source_url":"https://pubmed.ncbi.nlm.nih.gov/17226738/","study_design":null,"title":"Mild cognitive impairment: current research and clinical implications","title_match":false,"year":2007},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/qualitative-estimates-of-medial-temporal-atrophy-as-a-predictor-of-17210817","doi":"10.1001/archneur.64.1.108","journal":"Archives of neurology","n_participants":190,"pmid":"17210817","source_url":"https://pubmed.ncbi.nlm.nih.gov/17210817/","study_design":null,"title":"Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia","title_match":true,"year":2007},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/biomarkers-for-dementia-and-mild-cognitive-impairment-in-parkinson-s-27193487","doi":"10.1002/mds.26662","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"27193487","source_url":"https://pubmed.ncbi.nlm.nih.gov/27193487/","study_design":"longitudinal study","title":"Biomarkers for dementia and mild cognitive impairment in Parkinson's disease","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/synaptic-change-in-the-posterior-cingulate-gyrus-in-the-progression-25147118","doi":"10.3233/jad-141518","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25147118","source_url":"https://pubmed.ncbi.nlm.nih.gov/25147118/","study_design":null,"title":"Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/identification-and-validation-of-novel-cerebrospinal-fluid-biomarkers-21264269","doi":"10.1371/journal.pone.0016032","journal":"PloS one","n_participants":24,"pmid":"21264269","source_url":"https://pubmed.ncbi.nlm.nih.gov/21264269/","study_design":null,"title":"Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/obstructive-sleep-apnea-and-longitudinal-alzheimer-s-disease-30794315","doi":"10.1093/sleep/zsz048","journal":"Sleep","n_participants":516,"pmid":"30794315","source_url":"https://pubmed.ncbi.nlm.nih.gov/30794315/","study_design":"longitudinal study","title":"Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes","title_match":false,"year":2019},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-prevalence-and-progression-of-mild-cognitive-impairment-among-28884657","doi":"10.1017/s1041610217000473","journal":"International psychogeriatrics","n_participants":null,"pmid":"28884657","source_url":"https://pubmed.ncbi.nlm.nih.gov/28884657/","study_design":"meta-analysis","title":"The prevalence and progression of mild cognitive impairment among clinic and community populations: a systematic review and meta-analysis","title_match":true,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/differences-of-peripheral-inflammatory-markers-between-mild-cognitive-18367253","doi":"10.1016/j.imlet.2008.02.002","journal":"Immunology letters","n_participants":34,"pmid":"18367253","source_url":"https://pubmed.ncbi.nlm.nih.gov/18367253/","study_design":null,"title":"Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/factors-underlying-cognitive-decline-in-old-age-and-alzheimer-s-28422707","doi":"10.1515/revneuro-2016-0086","journal":"Reviews in the neurosciences","n_participants":null,"pmid":"28422707","source_url":"https://pubmed.ncbi.nlm.nih.gov/28422707/","study_design":null,"title":"Factors underlying cognitive decline in old age and Alzheimer's disease: the role of the hippocampus","title_match":false,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-cortisol-and-clinical-disease-progression-in-mci-25435336","doi":"10.1016/j.neurobiolaging.2014.10.031","journal":"Neurobiology of aging","n_participants":null,"pmid":"25435336","source_url":"https://pubmed.ncbi.nlm.nih.gov/25435336/","study_design":null,"title":"Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type","title_match":true,"year":2015},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/defining-alzheimer-as-a-common-age-related-neurodegenerative-process-22459297","doi":"10.1016/j.pneurobio.2012.03.005","journal":"Progress in neurobiology","n_participants":null,"pmid":"22459297","source_url":"https://pubmed.ncbi.nlm.nih.gov/22459297/","study_design":null,"title":"Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia","title_match":false,"year":2012},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/prevalence-distribution-and-impact-of-mild-cognitive-impairment-in-22346736","doi":"10.1371/journal.pmed.1001170","journal":"PLoS medicine","n_participants":15376,"pmid":"22346736","source_url":"https://pubmed.ncbi.nlm.nih.gov/22346736/","study_design":"cross-sectional","title":"Prevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: a 10/66 population-based study","title_match":false,"year":2012},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/cognition-deficits-in-parkinson-s-disease-mechanisms-and-treatment-32269747","doi":"10.1155/2020/2076942","journal":"Parkinson's disease","n_participants":null,"pmid":"32269747","source_url":"https://pubmed.ncbi.nlm.nih.gov/32269747/","study_design":null,"title":"Cognition Deficits in Parkinson's Disease: Mechanisms and Treatment","title_match":false,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/electromagnetic-signatures-of-the-preclinical-and-prodromal-stages-of-29522156","doi":"10.1093/brain/awy044","journal":"Brain : a journal of neurology","n_participants":17,"pmid":"29522156","source_url":"https://pubmed.ncbi.nlm.nih.gov/29522156/","study_design":null,"title":"Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/whole-brain-atrophy-rate-and-cognitive-decline-longitudinal-mr-study-18574133","doi":"10.1148/radiol.2482070938","journal":"Radiology","n_participants":65,"pmid":"18574133","source_url":"https://pubmed.ncbi.nlm.nih.gov/18574133/","study_design":null,"title":"Whole-brain atrophy rate and cognitive decline: longitudinal MR study of memory clinic patients","title_match":false,"year":2008},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/peripheral-levels-of-glutathione-and-protein-oxidation-as-markers-in-18297609","doi":"10.1080/10715760701861373","journal":"Free radical research","n_participants":34,"pmid":"18297609","source_url":"https://pubmed.ncbi.nlm.nih.gov/18297609/","study_design":null,"title":"Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment","title_match":false,"year":2008},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/choroid-plexus-volume-is-associated-with-levels-of-csf-proteins-32107064","doi":"10.1016/j.neurobiolaging.2020.01.005","journal":"Neurobiology of aging","n_participants":509,"pmid":"32107064","source_url":"https://pubmed.ncbi.nlm.nih.gov/32107064/","study_design":null,"title":"Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease","title_match":false,"year":2020},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/heightened-emotional-contagion-in-mild-cognitive-impairment-and-23716653","doi":"10.1073/pnas.1301119110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":237,"pmid":"23716653","source_url":"https://pubmed.ncbi.nlm.nih.gov/23716653/","study_design":null,"title":"Heightened emotional contagion in mild cognitive impairment and Alzheimer's disease is associated with temporal lobe degeneration","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-rate-of-conversion-of-mild-cognitive-impairment-to-dementia-17136705","doi":"10.1002/gps.1716","journal":"International journal of geriatric psychiatry","n_participants":105,"pmid":"17136705","source_url":"https://pubmed.ncbi.nlm.nih.gov/17136705/","study_design":"longitudinal study","title":"The rate of conversion of mild cognitive impairment to dementia: predictive role of depression","title_match":true,"year":2007},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-and-beta-amyloid-42-proteins-identify-12433260","doi":"10.1001/archneur.59.11.1729","journal":"Archives of neurology","n_participants":28,"pmid":"12433260","source_url":"https://pubmed.ncbi.nlm.nih.gov/12433260/","study_design":"longitudinal study","title":"Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment","title_match":false,"year":2002},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/impaired-glycemia-increases-disease-progression-in-mild-cognitive-24411018","doi":"10.1016/j.neurobiolaging.2013.09.033","journal":"Neurobiology of aging","n_participants":264,"pmid":"24411018","source_url":"https://pubmed.ncbi.nlm.nih.gov/24411018/","study_design":"longitudinal study","title":"Impaired glycemia increases disease progression in mild cognitive impairment","title_match":true,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/biomarker-based-prediction-of-progression-in-mci-comparison-of-ad-24130528","doi":"10.3389/fnagi.2013.00055","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"24130528","source_url":"https://pubmed.ncbi.nlm.nih.gov/24130528/","study_design":"clinical trial","title":"Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-\u03b2 and tau","title_match":true,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/increased-matrix-metalloproteinase-9-activity-in-mild-cognitive-19915485","doi":"10.1097/nen.0b013e3181c22569","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"19915485","source_url":"https://pubmed.ncbi.nlm.nih.gov/19915485/","study_design":null,"title":"Increased matrix metalloproteinase 9 activity in mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-in-mild-cognitive-impairment-a-literature-32289790","doi":"10.1159/000507078","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"32289790","source_url":"https://pubmed.ncbi.nlm.nih.gov/32289790/","study_design":null,"title":"Neuropsychiatric Symptoms in Mild Cognitive Impairment: A Literature Review","title_match":false,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/cognitive-reserve-and-clinical-progression-in-alzheimer-disease-a-31266904","doi":"10.1212/wnl.0000000000007821","journal":"Neurology","n_participants":175,"pmid":"31266904","source_url":"https://pubmed.ncbi.nlm.nih.gov/31266904/","study_design":"longitudinal study","title":"Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship","title_match":false,"year":2019},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/plasma-a42-40-ratio-detects-early-stages-of-alzheimer-s-disease-and-30569084","doi":"10.14283/jpad.2018.41","journal":"The journal of prevention of Alzheimer's disease","n_participants":145,"pmid":"30569084","source_url":"https://pubmed.ncbi.nlm.nih.gov/30569084/","study_design":null,"title":"Plasma A\u03b242/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study","title_match":false,"year":2019},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-in-a-community-sample-the-sydney-memory-and-23110866","doi":"10.1016/j.jalz.2011.11.010","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"23110866","source_url":"https://pubmed.ncbi.nlm.nih.gov/23110866/","study_design":"longitudinal study","title":"Mild cognitive impairment in a community sample: the Sydney Memory and Ageing Study","title_match":false,"year":2013},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/investigating-structural-brain-changes-of-dehydration-using-voxel-22952926","doi":"10.1371/journal.pone.0044195","journal":"PloS one","n_participants":null,"pmid":"22952926","source_url":"https://pubmed.ncbi.nlm.nih.gov/22952926/","study_design":"longitudinal study","title":"Investigating structural brain changes of dehydration using voxel-based morphometry","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/interleukin-1-interleukin-1-receptor-antagonist-interleukin-6-29478949","doi":"10.1016/j.cellimm.2018.02.011","journal":"Cellular immunology","n_participants":null,"pmid":"29478949","source_url":"https://pubmed.ncbi.nlm.nih.gov/29478949/","study_design":null,"title":"Interleukin-1\u03b2, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-\u03b1 levels in CSF and serum in relation to the clinical diversity of Parkinson's disease","title_match":false,"year":2018},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/sex-differences-in-progression-to-mild-cognitive-impairment-and-29478836","doi":"10.1016/j.parkreldis.2018.02.007","journal":"Parkinsonism & related disorders","n_participants":418,"pmid":"29478836","source_url":"https://pubmed.ncbi.nlm.nih.gov/29478836/","study_design":"longitudinal study","title":"Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/olfactory-cortex-degeneration-in-alzheimer-s-disease-and-mild-25633674","doi":"10.3233/jad-141947","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25633674","source_url":"https://pubmed.ncbi.nlm.nih.gov/25633674/","study_design":null,"title":"Olfactory cortex degeneration in Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/carbon-11-labeled-pittsburgh-compound-b-and-carbon-11-labeled-r-19139300","doi":"10.1001/archneurol.2008.511","journal":"Archives of neurology","n_participants":null,"pmid":"19139300","source_url":"https://pubmed.ncbi.nlm.nih.gov/19139300/","study_design":null,"title":"Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/diagnostic-contribution-and-therapeutic-perspectives-of-transcranial-34482205","doi":"10.1016/j.clinph.2021.05.035","journal":"Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology","n_participants":null,"pmid":"34482205","source_url":"https://pubmed.ncbi.nlm.nih.gov/34482205/","study_design":null,"title":"Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia","title_match":false,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/eeg-spectral-analysis-as-a-putative-early-prognostic-biomarker-in-28646686","doi":"10.1016/j.neurobiolaging.2017.05.017","journal":"Neurobiology of aging","n_participants":205,"pmid":"28646686","source_url":"https://pubmed.ncbi.nlm.nih.gov/28646686/","study_design":null,"title":"EEG spectral analysis as a putative early prognostic biomarker in nondemented, amyloid positive subjects","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/pharmacologic-inhibition-of-rock2-suppresses-amyloid-production-in-an-24305806","doi":"10.1523/jneurosci.2508-13.2013","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"24305806","source_url":"https://pubmed.ncbi.nlm.nih.gov/24305806/","study_design":null,"title":"Pharmacologic inhibition of ROCK2 suppresses amyloid-\u03b2 production in an Alzheimer's disease mouse model","title_match":false,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/efficacy-of-cognitive-rehabilitation-in-patients-with-mild-cognitive-17117398","doi":"10.1002/gps.1681","journal":"International journal of geriatric psychiatry","n_participants":59,"pmid":"17117398","source_url":"https://pubmed.ncbi.nlm.nih.gov/17117398/","study_design":"longitudinal study","title":"Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors","title_match":false,"year":2007},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/damage-to-lipids-proteins-dna-and-rna-in-mild-cognitive-impairment-17620484","doi":"10.1001/archneur.64.7.954","journal":"Archives of neurology","n_participants":null,"pmid":"17620484","source_url":"https://pubmed.ncbi.nlm.nih.gov/17620484/","study_design":null,"title":"Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/effectiveness-of-a-cognitive-rehabilitation-program-in-mild-dementia-17317481","doi":"10.1016/j.archger.2007.01.055","journal":"Archives of gerontology and geriatrics","n_participants":null,"pmid":"17317481","source_url":"https://pubmed.ncbi.nlm.nih.gov/17317481/","study_design":null,"title":"Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): a case control study","title_match":false,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/antioxidant-strategies-for-alzheimer-s-disease-12133201","doi":"10.1079/pns2002146","journal":"The Proceedings of the Nutrition Society","n_participants":null,"pmid":"12133201","source_url":"https://pubmed.ncbi.nlm.nih.gov/12133201/","study_design":null,"title":"Antioxidant strategies for Alzheimer's disease","title_match":false,"year":2002},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/the-differentiation-of-amnestic-type-mci-from-the-non-amnestic-types-27065855","doi":"10.3389/fnagi.2016.00052","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"27065855","source_url":"https://pubmed.ncbi.nlm.nih.gov/27065855/","study_design":null,"title":"The Differentiation of Amnestic Type MCI from the Non-Amnestic Types by Structural MRI","title_match":false,"year":2016},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/body-mass-index-weight-change-and-clinical-progression-in-mild-24126214","doi":"10.1097/wad.0000000000000005","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"24126214","source_url":"https://pubmed.ncbi.nlm.nih.gov/24126214/","study_design":"longitudinal study","title":"Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease","title_match":true,"year":2014},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/sex-differences-in-cognitive-decline-in-subjects-with-high-likelihood-29748598","doi":"10.1038/s41598-018-25377-w","journal":"Scientific reports","n_participants":null,"pmid":"29748598","source_url":"https://pubmed.ncbi.nlm.nih.gov/29748598/","study_design":null,"title":"Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-vilip-1-and-ykl-40-candidate-biomarkers-to-26383836","doi":"10.1186/s13195-015-0142-1","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"26383836","source_url":"https://pubmed.ncbi.nlm.nih.gov/26383836/","study_design":"longitudinal study","title":"Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/characterizing-alzheimer-s-disease-using-a-hypometabolic-convergence-21276856","doi":"10.1016/j.neuroimage.2011.01.049","journal":"NeuroImage","n_participants":null,"pmid":"21276856","source_url":"https://pubmed.ncbi.nlm.nih.gov/21276856/","study_design":null,"title":"Characterizing Alzheimer's disease using a hypometabolic convergence index","title_match":false,"year":2011},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-epidemiology-and-dementia-risk-in-an-18028343","doi":"10.1111/j.1532-5415.2007.01503.x","journal":"Journal of the American Geriatrics Society","n_participants":1016,"pmid":"18028343","source_url":"https://pubmed.ncbi.nlm.nih.gov/18028343/","study_design":"longitudinal study","title":"Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population","title_match":false,"year":2008},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/eeg-microstate-complexity-for-aiding-early-diagnosis-of-alzheimer-s-33077823","doi":"10.1038/s41598-020-74790-7","journal":"Scientific reports","n_participants":null,"pmid":"33077823","source_url":"https://pubmed.ncbi.nlm.nih.gov/33077823/","study_design":null,"title":"EEG microstate complexity for aiding early diagnosis of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/novel-white-matter-tract-integrity-metrics-sensitive-to-alzheimer-23764722","doi":"10.3174/ajnr.a3553","journal":"AJNR. American journal of neuroradiology","n_participants":12,"pmid":"23764722","source_url":"https://pubmed.ncbi.nlm.nih.gov/23764722/","study_design":null,"title":"Novel white matter tract integrity metrics sensitive to Alzheimer disease progression","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/toward-a-predictive-model-of-alzheimer-s-disease-progression-using-22967182","doi":"10.1021/ac301243k","journal":"Analytical chemistry","n_participants":85,"pmid":"22967182","source_url":"https://pubmed.ncbi.nlm.nih.gov/22967182/","study_design":null,"title":"Toward a predictive model of Alzheimer's disease progression using capillary electrophoresis-mass spectrometry metabolomics","title_match":false,"year":2012},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/prediction-and-longitudinal-study-of-csf-biomarkers-in-mild-cognitive-17889968","doi":"10.1016/j.neurobiolaging.2007.08.010","journal":"Neurobiology of aging","n_participants":86,"pmid":"17889968","source_url":"https://pubmed.ncbi.nlm.nih.gov/17889968/","study_design":"longitudinal study","title":"Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-profiled-by-fluid-and-imaging-markers-tau-pet-34593971","doi":"10.1038/s41380-021-01263-2","journal":"Molecular psychiatry","n_participants":282,"pmid":"34593971","source_url":"https://pubmed.ncbi.nlm.nih.gov/34593971/","study_design":"longitudinal study","title":"Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline","title_match":false,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/alzheimer-s-retinopathy-seeing-disease-in-the-eyes-33041751","doi":"10.3389/fnins.2020.00921","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"33041751","source_url":"https://pubmed.ncbi.nlm.nih.gov/33041751/","study_design":null,"title":"Alzheimer's Retinopathy: Seeing Disease in the Eyes","title_match":false,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/pet-staging-of-amyloidosis-using-striatum-29792874","doi":"10.1016/j.jalz.2018.04.011","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1433,"pmid":"29792874","source_url":"https://pubmed.ncbi.nlm.nih.gov/29792874/","study_design":null,"title":"PET staging of amyloidosis using striatum","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/odor-identification-deficit-predicts-clinical-conversion-from-mild-23669447","doi":"10.1093/arclin/act032","journal":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","n_participants":null,"pmid":"23669447","source_url":"https://pubmed.ncbi.nlm.nih.gov/23669447/","study_design":"longitudinal study","title":"Odor identification deficit predicts clinical conversion from mild cognitive impairment to dementia due to Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/upregulation-of-select-rab-gtpases-in-cholinergic-basal-forebrain-21669283","doi":"10.1016/j.jchemneu.2011.05.012","journal":"Journal of chemical neuroanatomy","n_participants":null,"pmid":"21669283","source_url":"https://pubmed.ncbi.nlm.nih.gov/21669283/","study_design":null,"title":"Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/cind-and-mci-in-the-italian-elderly-frequency-vascular-risk-factors-17536047","doi":"10.1212/01.wnl.0000263132.99055.0d","journal":"Neurology","n_participants":null,"pmid":"17536047","source_url":"https://pubmed.ncbi.nlm.nih.gov/17536047/","study_design":"longitudinal study","title":"CIND and MCI in the Italian elderly: frequency, vascular risk factors, progression to dementia","title_match":true,"year":2007},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-can-be-accurately-diagnosed-in-very-mildly-12370456","doi":"10.1212/wnl.59.7.1022","journal":"Neurology","n_participants":12,"pmid":"12370456","source_url":"https://pubmed.ncbi.nlm.nih.gov/12370456/","study_design":null,"title":"Alzheimer's disease can be accurately diagnosed in very mildly impaired individuals","title_match":false,"year":2002},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/resting-state-abnormalities-of-the-default-mode-network-in-mild-31177210","doi":"10.3233/jad-180847","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31177210","source_url":"https://pubmed.ncbi.nlm.nih.gov/31177210/","study_design":"meta-analysis","title":"Resting State Abnormalities of the Default Mode Network in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis","title_match":false,"year":2019},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/risk-of-conversion-to-dementia-in-a-mild-behavioral-impairment-group-29439333","doi":"10.3233/jad-170632","journal":"Journal of Alzheimer's disease : JAD","n_participants":348,"pmid":"29439333","source_url":"https://pubmed.ncbi.nlm.nih.gov/29439333/","study_design":null,"title":"Risk of Conversion to Dementia in a Mild Behavioral Impairment Group Compared to a Psychiatric Group and to a Mild Cognitive Impairment Group","title_match":true,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/electroencephalography-and-event-related-potentials-as-biomarkers-of-18631990","doi":"10.1016/j.jalz.2007.10.008","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"18631990","source_url":"https://pubmed.ncbi.nlm.nih.gov/18631990/","study_design":null,"title":"Electroencephalography and event-related potentials as biomarkers of mild cognitive impairment and mild Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-an-opportunity-to-identify-patients-at-high-16990077","doi":"10.1016/j.clinthera.2006.07.006","journal":"Clinical therapeutics","n_participants":769,"pmid":"16990077","source_url":"https://pubmed.ncbi.nlm.nih.gov/16990077/","study_design":null,"title":"Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease","title_match":true,"year":2006},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/pin1-in-alzheimer-s-disease-16945100","doi":"10.1111/j.1471-4159.2006.03995.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"16945100","source_url":"https://pubmed.ncbi.nlm.nih.gov/16945100/","study_design":null,"title":"Pin1 in Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/machine-learning-for-comprehensive-forecasting-of-alzheimer-s-disease-31541187","doi":"10.1038/s41598-019-49656-2","journal":"Scientific reports","n_participants":1909,"pmid":"31541187","source_url":"https://pubmed.ncbi.nlm.nih.gov/31541187/","study_design":null,"title":"Machine learning for comprehensive forecasting of Alzheimer's Disease progression","title_match":false,"year":2019},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/fdg-pet-as-an-independent-biomarker-for-alzheimer-s-biological-31253185","doi":"10.1186/s13195-019-0512-1","journal":"Alzheimer's research & therapy","n_participants":551,"pmid":"31253185","source_url":"https://pubmed.ncbi.nlm.nih.gov/31253185/","study_design":"longitudinal study","title":"FDG-PET as an independent biomarker for Alzheimer's biological diagnosis: a longitudinal study","title_match":false,"year":2019},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/neuropsychological-criteria-for-mild-cognitive-impairment-and-27029348","doi":"10.1017/s1355617716000199","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":58,"pmid":"27029348","source_url":"https://pubmed.ncbi.nlm.nih.gov/27029348/","study_design":null,"title":"Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study","title_match":false,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/decreased-levels-of-circulating-adiponectin-in-mild-cognitive-23055000","doi":"10.1007/s12017-012-8201-2","journal":"Neuromolecular medicine","n_participants":157,"pmid":"23055000","source_url":"https://pubmed.ncbi.nlm.nih.gov/23055000/","study_design":null,"title":"Decreased levels of circulating adiponectin in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/longitudinal-imaging-of-alzheimer-pathology-using-11c-pib-18f-fddnp-22441582","doi":"10.1007/s00259-012-2102-3","journal":"European journal of nuclear medicine and molecular imaging","n_participants":null,"pmid":"22441582","source_url":"https://pubmed.ncbi.nlm.nih.gov/22441582/","study_design":"longitudinal study","title":"Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/five-out-of-16-plasma-signaling-proteins-are-enhanced-in-plasma-of-19395124","doi":"10.1016/j.neurobiolaging.2009.03.011","journal":"Neurobiology of aging","n_participants":null,"pmid":"19395124","source_url":"https://pubmed.ncbi.nlm.nih.gov/19395124/","study_design":null,"title":"Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/role-of-oxidative-damage-in-alzheimer-s-disease-and-neurodegeneration-34572985","doi":"10.3390/antiox10091353","journal":"Antioxidants (Basel, Switzerland)","n_participants":null,"pmid":"34572985","source_url":"https://pubmed.ncbi.nlm.nih.gov/34572985/","study_design":null,"title":"Role of Oxidative Damage in Alzheimer's Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery","title_match":false,"year":2021},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-relationship-between-anxiety-and-alzheimer-s-disease-33981954","doi":"10.3233/adr-210294","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"33981954","source_url":"https://pubmed.ncbi.nlm.nih.gov/33981954/","study_design":null,"title":"The Relationship Between Anxiety and Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/engagement-in-social-activities-and-progression-from-mild-to-severe-23257280","doi":"10.1017/s1041610212002086","journal":"International psychogeriatrics","n_participants":78,"pmid":"23257280","source_url":"https://pubmed.ncbi.nlm.nih.gov/23257280/","study_design":"cohort study","title":"Engagement in social activities and progression from mild to severe cognitive impairment: the MYHAT study","title_match":false,"year":2013},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/maintenance-treatment-of-depression-in-old-age-a-randomized-double-21199965","doi":"10.1001/archgenpsychiatry.2010.184","journal":"Archives of general psychiatry","n_participants":73,"pmid":"21199965","source_url":"https://pubmed.ncbi.nlm.nih.gov/21199965/","study_design":null,"title":"Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy","title_match":false,"year":2011},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/decreased-rna-and-increased-rna-oxidation-in-ribosomes-from-early-16770743","doi":"10.1007/s11064-006-9071-5","journal":"Neurochemical research","n_participants":null,"pmid":"16770743","source_url":"https://pubmed.ncbi.nlm.nih.gov/16770743/","study_design":null,"title":"Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/synaptic-biomarkers-in-csf-aid-in-diagnosis-correlate-with-cognition-31853477","doi":"10.1016/j.trci.2019.11.002","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"31853477","source_url":"https://pubmed.ncbi.nlm.nih.gov/31853477/","study_design":null,"title":"Synaptic biomarkers in CSF aid in diagnosis, correlate with cognition and predict progression in MCI and Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/metabolic-syndrome-mild-cognitive-impairment-and-dementia-a-meta-30917904","doi":"10.1016/j.jagp.2019.01.214","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":18313,"pmid":"30917904","source_url":"https://pubmed.ncbi.nlm.nih.gov/30917904/","study_design":"systematic review","title":"Metabolic Syndrome, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Longitudinal Studies","title_match":false,"year":2019},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cognitive-frailty-a-systematic-review-of-epidemiological-and-25808052","doi":"10.1089/rej.2014.1637","journal":"Rejuvenation research","n_participants":null,"pmid":"25808052","source_url":"https://pubmed.ncbi.nlm.nih.gov/25808052/","study_design":"systematic review","title":"Cognitive Frailty: A Systematic Review of Epidemiological and Neurobiological Evidence of an Age-Related Clinical Condition","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/changes-in-cognition-22078174","doi":"10.1016/j.neurobiolaging.2011.09.010","journal":"Neurobiology of aging","n_participants":null,"pmid":"22078174","source_url":"https://pubmed.ncbi.nlm.nih.gov/22078174/","study_design":null,"title":"Changes in cognition","title_match":false,"year":2011},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/progression-of-tau-pathology-in-cholinergic-basal-forebrain-neurons-21945902","doi":"10.1016/j.ajpath.2011.07.044","journal":"The American journal of pathology","n_participants":null,"pmid":"21945902","source_url":"https://pubmed.ncbi.nlm.nih.gov/21945902/","study_design":null,"title":"Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease","title_match":true,"year":2011},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/predictive-value-of-apoe-4-allele-for-progression-from-mci-to-ad-type-21493755","doi":"10.1136/jnnp.2010.231555","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":35,"pmid":"21493755","source_url":"https://pubmed.ncbi.nlm.nih.gov/21493755/","study_design":"meta-analysis","title":"Predictive value of APOE-\u03b54 allele for progression from MCI to AD-type dementia: a meta-analysis","title_match":true,"year":2011},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/dysexecutive-versus-amnesic-phenotypes-of-very-mild-alzheimer-s-20562467","doi":"10.1136/jnnp.2009.199505","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":100,"pmid":"20562467","source_url":"https://pubmed.ncbi.nlm.nih.gov/20562467/","study_design":null,"title":"Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/does-mild-cognitive-impairment-always-lead-to-dementia-a-review-27653867","doi":"10.1016/j.jns.2016.07.055","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"27653867","source_url":"https://pubmed.ncbi.nlm.nih.gov/27653867/","study_design":"longitudinal study","title":"Does mild cognitive impairment always lead to dementia? A review","title_match":false,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/auditory-verbal-learning-test-is-superior-to-rey-osterrieth-complex-26027810","doi":"10.2174/1567205012666150530202729","journal":"Current Alzheimer research","n_participants":95,"pmid":"26027810","source_url":"https://pubmed.ncbi.nlm.nih.gov/26027810/","study_design":null,"title":"Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/four-subgroups-of-alzheimer-s-disease-based-on-patterns-of-atrophy-16904912","doi":"10.1016/j.neuroimage.2006.06.010","journal":"NeuroImage","n_participants":20,"pmid":"16904912","source_url":"https://pubmed.ncbi.nlm.nih.gov/16904912/","study_design":null,"title":"Four subgroups of Alzheimer's disease based on patterns of atrophy using VBM and a unique pattern for early onset disease","title_match":false,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/assessing-the-preparedness-of-the-health-care-system-infrastructure-31205802","doi":"10.7249/rr2503","journal":"Rand health quarterly","n_participants":null,"pmid":"31205802","source_url":"https://pubmed.ncbi.nlm.nih.gov/31205802/","study_design":null,"title":"Assessing the Preparedness of the Health Care System Infrastructure in Six European Countries for an Alzheimer's Treatment","title_match":false,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/circulating-levels-of-il-1-family-cytokines-and-receptors-in-30541566","doi":"10.1186/s12974-018-1376-1","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"30541566","source_url":"https://pubmed.ncbi.nlm.nih.gov/30541566/","study_design":null,"title":"Circulating levels of IL-1 family cytokines and receptors in Alzheimer's disease: new markers of disease progression?","title_match":false,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/bile-acid-quantification-of-20-plasma-metabolites-identifies-29249916","doi":"10.1007/s11306-017-1297-5","journal":"Metabolomics : Official journal of the Metabolomic Society","n_participants":20,"pmid":"29249916","source_url":"https://pubmed.ncbi.nlm.nih.gov/29249916/","study_design":null,"title":"Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/decreased-peripheral-brain-derived-neurotrophic-factor-levels-in-27113997","doi":"10.1038/mp.2016.62","journal":"Molecular psychiatry","n_participants":null,"pmid":"27113997","source_url":"https://pubmed.ncbi.nlm.nih.gov/27113997/","study_design":"meta-analysis","title":"Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer's disease: a meta-analysis study (N=7277)","title_match":false,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cerebral-perfusion-in-the-predementia-stages-of-alzheimer-s-disease-26040647","doi":"10.1007/s00330-015-3834-9","journal":"European radiology","n_participants":177,"pmid":"26040647","source_url":"https://pubmed.ncbi.nlm.nih.gov/26040647/","study_design":null,"title":"Cerebral perfusion in the predementia stages of Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/voxelwise-meta-analysis-of-gray-matter-anomalies-in-alzheimer-s-22385679","doi":"10.1016/j.jns.2012.02.010","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"22385679","source_url":"https://pubmed.ncbi.nlm.nih.gov/22385679/","study_design":"systematic review","title":"Voxelwise meta-analysis of gray matter anomalies in Alzheimer's disease and mild cognitive impairment using anatomic likelihood estimation","title_match":false,"year":2012},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/risk-of-dementia-in-mci-combined-effect-of-cerebrovascular-disease-19398707","doi":"10.1212/wnl.0b013e3181a2e864","journal":"Neurology","n_participants":null,"pmid":"19398707","source_url":"https://pubmed.ncbi.nlm.nih.gov/19398707/","study_design":null,"title":"Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS","title_match":false,"year":2009},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/neural-biomarker-diagnosis-and-prediction-to-mild-cognitive-36765411","doi":"10.1186/s13195-023-01181-1","journal":"Alzheimer's research & therapy","n_participants":890,"pmid":"36765411","source_url":"https://pubmed.ncbi.nlm.nih.gov/36765411/","study_design":null,"title":"Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer's disease using EEG technology","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/from-mild-cognitive-impairment-to-subjective-cognitive-decline-28243102","doi":"10.2147/ndt.s123428","journal":"Neuropsychiatric disease and treatment","n_participants":null,"pmid":"28243102","source_url":"https://pubmed.ncbi.nlm.nih.gov/28243102/","study_design":"cross-sectional","title":"From mild cognitive impairment to subjective cognitive decline: conceptual and methodological evolution","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/pattern-of-regional-cortical-thinning-associated-with-cognitive-23359616","doi":"10.1371/journal.pone.0054980","journal":"PloS one","n_participants":26,"pmid":"23359616","source_url":"https://pubmed.ncbi.nlm.nih.gov/23359616/","study_design":null,"title":"Pattern of regional cortical thinning associated with cognitive deterioration in Parkinson's disease","title_match":false,"year":2013},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/do-csf-total-tau-phosphorylated-tau-and-beta-amyloid-42-help-to-17886169","doi":"10.1080/15622970701535502","journal":"The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry","n_participants":123,"pmid":"17886169","source_url":"https://pubmed.ncbi.nlm.nih.gov/17886169/","study_design":"systematic review","title":"Do CSF total tau, phosphorylated tau, and beta-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature","title_match":true,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-16085780","doi":"10.1176/appi.ajgp.13.8.645","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"16085780","source_url":"https://pubmed.ncbi.nlm.nih.gov/16085780/","study_design":null,"title":"Mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/effect-of-probiotic-bifidobacterium-breve-in-improving-cognitive-35570493","doi":"10.3233/jad-220148","journal":"Journal of Alzheimer's disease : JAD","n_participants":130,"pmid":"35570493","source_url":"https://pubmed.ncbi.nlm.nih.gov/35570493/","study_design":null,"title":"Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/technologies-for-cognitive-training-and-cognitive-rehabilitation-for-32373018","doi":"10.3389/fpsyg.2020.00648","journal":"Frontiers in psychology","n_participants":null,"pmid":"32373018","source_url":"https://pubmed.ncbi.nlm.nih.gov/32373018/","study_design":"systematic review","title":"Technologies for Cognitive Training and Cognitive Rehabilitation for People With Mild Cognitive Impairment and Dementia. A Systematic Review","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-prevention-initiative-autosomal-dominant-alzheimer-s-29955659","doi":"10.1016/j.trci.2018.02.002","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":300,"pmid":"29955659","source_url":"https://pubmed.ncbi.nlm.nih.gov/29955659/","study_design":"clinical trial","title":"The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort","title_match":false,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/risk-of-progression-from-subjective-cognitive-decline-to-mild-29352855","doi":"10.1016/j.jalz.2017.12.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":113,"pmid":"29352855","source_url":"https://pubmed.ncbi.nlm.nih.gov/29352855/","study_design":null,"title":"Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/syntax-action-verbs-action-semantics-and-object-semantics-in-26103601","doi":"10.1016/j.cortex.2015.05.022","journal":"Cortex; a journal devoted to the study of the nervous system and behavior","n_participants":null,"pmid":"26103601","source_url":"https://pubmed.ncbi.nlm.nih.gov/26103601/","study_design":null,"title":"Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/nadph-oxidase-activation-and-cognition-in-alzheimer-disease-21457777","doi":"10.1016/j.freeradbiomed.2011.03.025","journal":"Free radical biology & medicine","n_participants":null,"pmid":"21457777","source_url":"https://pubmed.ncbi.nlm.nih.gov/21457777/","study_design":null,"title":"NADPH-oxidase activation and cognition in Alzheimer disease progression","title_match":false,"year":2011},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-in-aging-and-dementia-testing-the-amyloid-hypothesis-19847050","doi":"10.3233/ben-2009-0232","journal":"Behavioural neurology","n_participants":null,"pmid":"19847050","source_url":"https://pubmed.ncbi.nlm.nih.gov/19847050/","study_design":null,"title":"Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo","title_match":false,"year":2009},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/paradoxical-upregulation-of-glutamatergic-presynaptic-boutons-during-17913914","doi":"10.1523/jneurosci.3269-07.2007","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"17913914","source_url":"https://pubmed.ncbi.nlm.nih.gov/17913914/","study_design":null,"title":"Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-humanistic-and-economic-burden-of-alzheimer-s-disease-35192176","doi":"10.1007/s40120-022-00335-x","journal":"Neurology and therapy","n_participants":null,"pmid":"35192176","source_url":"https://pubmed.ncbi.nlm.nih.gov/35192176/","study_design":null,"title":"The Humanistic and Economic Burden of Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/trajectories-of-the-hippocampal-subfields-atrophy-in-the-alzheimer-s-30983985","doi":"10.3389/fninf.2019.00013","journal":"Frontiers in neuroinformatics","n_participants":null,"pmid":"30983985","source_url":"https://pubmed.ncbi.nlm.nih.gov/30983985/","study_design":"longitudinal study","title":"Trajectories of the Hippocampal Subfields Atrophy in the Alzheimer's Disease: A Structural Imaging Study","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/disease-tracking-markers-for-alzheimer-s-disease-at-the-prodromal-mci-21971460","doi":"10.3233/jad-2011-0043","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21971460","source_url":"https://pubmed.ncbi.nlm.nih.gov/21971460/","study_design":"cross-sectional","title":"Disease tracking markers for Alzheimer's disease at the prodromal (MCI) stage","title_match":false,"year":2011},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-clusterin-concentration-is-associated-with-longitudinal-brain-21824521","doi":"10.1016/j.neuroimage.2011.07.056","journal":"NeuroImage","n_participants":139,"pmid":"21824521","source_url":"https://pubmed.ncbi.nlm.nih.gov/21824521/","study_design":"longitudinal study","title":"Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-of-lewy-body-associated-disorders-20922808","doi":"10.1002/mds.23393","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"20922808","source_url":"https://pubmed.ncbi.nlm.nih.gov/20922808/","study_design":"longitudinal study","title":"Amyloid imaging of Lewy body-associated disorders","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/regional-selectivity-of-rab5-and-rab7-protein-upregulation-in-mild-20847427","doi":"10.3233/jad-2010-101080","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20847427","source_url":"https://pubmed.ncbi.nlm.nih.gov/20847427/","study_design":null,"title":"Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-dynamics-of-alzheimer-s-disease-biomarkers-in-the-alzheimer-s-20538373","doi":"10.1016/j.neurobiolaging.2010.04.024","journal":"Neurobiology of aging","n_participants":null,"pmid":"20538373","source_url":"https://pubmed.ncbi.nlm.nih.gov/20538373/","study_design":null,"title":"The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/longitudinal-brain-metabolic-changes-from-amnestic-mild-cognitive-19477964","doi":"10.1093/brain/awp132","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"19477964","source_url":"https://pubmed.ncbi.nlm.nih.gov/19477964/","study_design":null,"title":"Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/progression-to-dementia-or-reversion-to-normal-cognition-in-mild-35351783","doi":"10.1212/wnl.0000000000200256","journal":"Neurology","n_participants":409,"pmid":"35351783","source_url":"https://pubmed.ncbi.nlm.nih.gov/35351783/","study_design":null,"title":"Progression to Dementia or Reversion to Normal Cognition in Mild Cognitive Impairment as a Function of Late-Onset Neuropsychiatric Symptoms","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/spect-and-pet-imaging-in-alzheimer-s-disease-30128693","doi":"10.1007/s12149-018-1292-6","journal":"Annals of nuclear medicine","n_participants":null,"pmid":"30128693","source_url":"https://pubmed.ncbi.nlm.nih.gov/30128693/","study_design":null,"title":"SPECT and PET imaging in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/disrupted-network-topology-in-patients-with-stable-and-progressive-27178195","doi":"10.1093/cercor/bhw128","journal":"Cerebral cortex (New York, N.Y. : 1991)","n_participants":null,"pmid":"27178195","source_url":"https://pubmed.ncbi.nlm.nih.gov/27178195/","study_design":null,"title":"Disrupted Network Topology in Patients with Stable and Progressive Mild Cognitive Impairment and Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/eeg-characteristics-in-eyes-open-versus-eyes-closed-conditions-small-26603651","doi":"10.1016/j.clinph.2015.07.040","journal":"Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology","n_participants":null,"pmid":"26603651","source_url":"https://pubmed.ncbi.nlm.nih.gov/26603651/","study_design":null,"title":"EEG characteristics in \"eyes-open\" versus \"eyes-closed\" conditions: Small-world network architecture in healthy aging and age-related brain degeneration","title_match":false,"year":2016},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/self-rated-and-informant-rated-everyday-function-in-comparison-to-25449531","doi":"10.1016/j.jalz.2014.09.002","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1080,"pmid":"25449531","source_url":"https://pubmed.ncbi.nlm.nih.gov/25449531/","study_design":null,"title":"Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/peripheral-oxidative-damage-in-mild-cognitive-impairment-and-mild-18780972","doi":"10.3233/jad-2008-15110","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"18780972","source_url":"https://pubmed.ncbi.nlm.nih.gov/18780972/","study_design":null,"title":"Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tau-pet-correlates-with-different-alzheimer-s-disease-related-34254442","doi":"10.15252/emmm.202114398","journal":"EMBO molecular medicine","n_participants":400,"pmid":"34254442","source_url":"https://pubmed.ncbi.nlm.nih.gov/34254442/","study_design":null,"title":"Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/whole-brain-analysis-reveals-increased-neuroanatomical-asymmetries-in-27913407","doi":"10.1093/brain/aww243","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"27913407","source_url":"https://pubmed.ncbi.nlm.nih.gov/27913407/","study_design":"longitudinal study","title":"Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala","title_match":false,"year":2016},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/proteomic-profiling-of-extracellular-vesicles-derived-from-32854315","doi":"10.3390/cells9091959","journal":"Cells","n_participants":13,"pmid":"32854315","source_url":"https://pubmed.ncbi.nlm.nih.gov/32854315/","study_design":null,"title":"Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study","title_match":false,"year":2020},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/recommendations-for-cerebrospinal-fluid-alzheimer-s-disease-28341066","doi":"10.1016/j.jalz.2016.09.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"28341066","source_url":"https://pubmed.ncbi.nlm.nih.gov/28341066/","study_design":null,"title":"Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-in-parkinson-s-disease-and-its-progression-25676160","doi":"10.1002/gps.4261","journal":"International journal of geriatric psychiatry","n_participants":166,"pmid":"25676160","source_url":"https://pubmed.ncbi.nlm.nih.gov/25676160/","study_design":null,"title":"Mild cognitive impairment in Parkinson's disease and its progression onto dementia: a 16-year outcome evaluation of the Denbighshire cohort","title_match":true,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/rapid-progression-from-mild-cognitive-impairment-to-alzheimer-s-19420940","doi":"10.1159/000216841","journal":"Dementia and geriatric cognitive disorders","n_participants":58,"pmid":"19420940","source_url":"https://pubmed.ncbi.nlm.nih.gov/19420940/","study_design":null,"title":"Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype","title_match":true,"year":2009},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/diagnostic-and-prognostic-performance-to-detect-alzheimer-s-disease-35568889","doi":"10.1186/s13195-022-01005-8","journal":"Alzheimer's research & therapy","n_participants":25,"pmid":"35568889","source_url":"https://pubmed.ncbi.nlm.nih.gov/35568889/","study_design":null,"title":"Diagnostic and prognostic performance to detect Alzheimer's disease and clinical progression of a novel assay for plasma p-tau217","title_match":false,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/japanese-and-north-american-alzheimer-s-disease-neuroimaging-29753531","doi":"10.1016/j.jalz.2018.03.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":75,"pmid":"29753531","source_url":"https://pubmed.ncbi.nlm.nih.gov/29753531/","study_design":null,"title":"Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials","title_match":false,"year":2018},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-neuropathological-profile-of-mild-cognitive-impairment-mci-a-22143004","doi":"10.1038/mp.2011.147","journal":"Molecular psychiatry","n_participants":162,"pmid":"22143004","source_url":"https://pubmed.ncbi.nlm.nih.gov/22143004/","study_design":"systematic review","title":"The neuropathological profile of mild cognitive impairment (MCI): a systematic review","title_match":false,"year":2012},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/nutraceutical-properties-of-mediterranean-diet-and-cognitive-decline-20858954","doi":"10.3233/jad-2010-100942","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20858954","source_url":"https://pubmed.ncbi.nlm.nih.gov/20858954/","study_design":null,"title":"Nutraceutical properties of Mediterranean diet and cognitive decline: possible underlying mechanisms","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/temporal-trends-in-the-long-term-risk-of-progression-of-mild-19010949","doi":"10.1136/jnnp.2007.142679","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"19010949","source_url":"https://pubmed.ncbi.nlm.nih.gov/19010949/","study_design":"cohort study","title":"Temporal trends in the long term risk of progression of mild cognitive impairment: a pooled analysis","title_match":true,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/proteomic-identification-of-nitrated-brain-proteins-in-early-18752637","doi":"10.1111/j.1582-4934.2008.00478.x","journal":"Journal of cellular and molecular medicine","n_participants":null,"pmid":"18752637","source_url":"https://pubmed.ncbi.nlm.nih.gov/18752637/","study_design":null,"title":"Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule","title_match":false,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/three-dimensional-surface-mapping-of-hippocampal-atrophy-progression-18289618","doi":"10.1016/j.neuropsychologia.2007.11.037","journal":"Neuropsychologia","n_participants":null,"pmid":"18289618","source_url":"https://pubmed.ncbi.nlm.nih.gov/18289618/","study_design":"longitudinal study","title":"Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry","title_match":true,"year":2008},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/combined-99mtc-ecd-spect-and-neuropsychological-studies-in-mci-for-16298237","doi":"10.1016/j.neurobiolaging.2004.12.010","journal":"Neurobiology of aging","n_participants":null,"pmid":"16298237","source_url":"https://pubmed.ncbi.nlm.nih.gov/16298237/","study_design":null,"title":"Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD","title_match":true,"year":2006},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/distinct-tau-pet-patterns-in-atrophy-defined-subtypes-of-alzheimer-s-31672482","doi":"10.1016/j.jalz.2019.08.201","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31672482","source_url":"https://pubmed.ncbi.nlm.nih.gov/31672482/","study_design":null,"title":"Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/structural-covariance-of-the-default-network-in-healthy-and-24048852","doi":"10.1523/jneurosci.2261-13.2013","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":414,"pmid":"24048852","source_url":"https://pubmed.ncbi.nlm.nih.gov/24048852/","study_design":"cross-sectional","title":"Structural covariance of the default network in healthy and pathological aging","title_match":false,"year":2013},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/metabolic-syndrome-and-cognitive-impairment-current-epidemiology-and-20571214","doi":"10.3233/jad-2010-091669","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20571214","source_url":"https://pubmed.ncbi.nlm.nih.gov/20571214/","study_design":null,"title":"Metabolic syndrome and cognitive impairment: current epidemiology and possible underlying mechanisms","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/peripheral-inflammatory-cytokines-as-biomarkers-in-alzheimer-s-17934323","doi":"10.1159/000107700","journal":"Neuro-degenerative diseases","n_participants":null,"pmid":"17934323","source_url":"https://pubmed.ncbi.nlm.nih.gov/17934323/","study_design":null,"title":"Peripheral inflammatory cytokines as biomarkers in Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/effects-of-intensive-lifestyle-changes-on-the-progression-of-mild-38849944","doi":"10.1186/s13195-024-01482-z","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"38849944","source_url":"https://pubmed.ncbi.nlm.nih.gov/38849944/","study_design":"clinical trial","title":"Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial","title_match":true,"year":2024},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/early-versus-late-mci-improved-mci-staging-using-a-neuropsychological-30737119","doi":"10.1016/j.jalz.2018.12.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"30737119","source_url":"https://pubmed.ncbi.nlm.nih.gov/30737119/","study_design":null,"title":"Early versus late MCI: Improved MCI staging using a neuropsychological approach","title_match":false,"year":2019},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/subjective-cognitive-decline-the-first-clinical-manifestation-of-29213452","doi":"10.1590/s1980-5764-2016dn1003002","journal":"Dementia & neuropsychologia","n_participants":null,"pmid":"29213452","source_url":"https://pubmed.ncbi.nlm.nih.gov/29213452/","study_design":"systematic review","title":"Subjective cognitive decline: The first clinical manifestation of Alzheimer's disease?","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/rho-associated-protein-kinase-1-rock1-is-increased-in-alzheimer-s-27246255","doi":"10.1111/jnc.13688","journal":"Journal of neurochemistry","n_participants":null,"pmid":"27246255","source_url":"https://pubmed.ncbi.nlm.nih.gov/27246255/","study_design":null,"title":"Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-\u03b2 levels in brain","title_match":false,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/aberrant-intra-and-inter-network-connectivity-architectures-in-26439278","doi":"10.1038/srep14824","journal":"Scientific reports","n_participants":null,"pmid":"26439278","source_url":"https://pubmed.ncbi.nlm.nih.gov/26439278/","study_design":null,"title":"Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/integration-and-relative-value-of-biomarkers-for-prediction-of-mci-to-24371799","doi":"10.1016/j.nicl.2013.11.010","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"24371799","source_url":"https://pubmed.ncbi.nlm.nih.gov/24371799/","study_design":null,"title":"Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers","title_match":true,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/ushering-in-the-study-and-treatment-of-preclinical-alzheimer-disease-23752908","doi":"10.1038/nrneurol.2013.107","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"23752908","source_url":"https://pubmed.ncbi.nlm.nih.gov/23752908/","study_design":null,"title":"Ushering in the study and treatment of preclinical Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-and-global-functional-impairment-along-the-22922821","doi":"10.1159/000342119","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"22922821","source_url":"https://pubmed.ncbi.nlm.nih.gov/22922821/","study_design":null,"title":"Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/metabolic-syndrome-mild-cognitive-impairment-and-alzheimer-s-disease-22921944","doi":"10.1016/j.brainresbull.2012.08.003","journal":"Brain research bulletin","n_participants":null,"pmid":"22921944","source_url":"https://pubmed.ncbi.nlm.nih.gov/22921944/","study_design":null,"title":"Metabolic syndrome, mild cognitive impairment and Alzheimer's disease--the emerging role of systemic low-grade inflammation and adiposity","title_match":false,"year":2012},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/donepezil-delays-progression-to-ad-in-mci-subjects-with-depressive-19528519","doi":"10.1212/wnl.0b013e3181aa52d3","journal":"Neurology","n_participants":208,"pmid":"19528519","source_url":"https://pubmed.ncbi.nlm.nih.gov/19528519/","study_design":null,"title":"Donepezil delays progression to AD in MCI subjects with depressive symptoms","title_match":true,"year":2009},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-and-everyday-function-evidence-of-reduced-18448852","doi":"10.1097/jgp.0b013e31816b7303","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"18448852","source_url":"https://pubmed.ncbi.nlm.nih.gov/18448852/","study_design":"cross-sectional","title":"Mild cognitive impairment and everyday function: evidence of reduced speed in performing instrumental activities of daily living","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/progression-to-dementia-in-clinical-subtypes-of-mild-cognitive-16679762","doi":"10.1159/000093101","journal":"Dementia and geriatric cognitive disorders","n_participants":32,"pmid":"16679762","source_url":"https://pubmed.ncbi.nlm.nih.gov/16679762/","study_design":null,"title":"Progression to dementia in clinical subtypes of mild cognitive impairment","title_match":true,"year":2006},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/gender-differences-in-risk-factors-for-transition-from-mild-cognitive-26343475","doi":"10.1016/j.comppsych.2015.07.002","journal":"Comprehensive psychiatry","n_participants":294,"pmid":"26343475","source_url":"https://pubmed.ncbi.nlm.nih.gov/26343475/","study_design":"cohort study","title":"Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/folates-and-aging-role-in-mild-cognitive-impairment-dementia-and-25939915","doi":"10.1016/j.arr.2015.04.005","journal":"Ageing research reviews","n_participants":null,"pmid":"25939915","source_url":"https://pubmed.ncbi.nlm.nih.gov/25939915/","study_design":null,"title":"Folates and aging: Role in mild cognitive impairment, dementia and depression","title_match":false,"year":2015},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/a-prospective-study-of-chronic-obstructive-pulmonary-disease-and-the-24637951","doi":"10.1001/jamaneurol.2014.94","journal":"JAMA neurology","n_participants":1425,"pmid":"24637951","source_url":"https://pubmed.ncbi.nlm.nih.gov/24637951/","study_design":"cross-sectional","title":"A prospective study of chronic obstructive pulmonary disease and the risk for mild cognitive impairment","title_match":false,"year":2014},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/a-multicenter-blinded-randomized-factorial-controlled-trial-of-22718435","doi":"10.1002/gps.3846","journal":"International journal of geriatric psychiatry","n_participants":305,"pmid":"22718435","source_url":"https://pubmed.ncbi.nlm.nih.gov/22718435/","study_design":"randomized controlled trial","title":"A multicenter, blinded, randomized, factorial controlled trial of doxycycline and rifampin for treatment of Alzheimer's disease: the DARAD trial","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/surface-based-tbm-boosts-power-to-detect-disease-effects-on-the-brain-21440071","doi":"10.1016/j.neuroimage.2011.03.040","journal":"NeuroImage","n_participants":490,"pmid":"21440071","source_url":"https://pubmed.ncbi.nlm.nih.gov/21440071/","study_design":null,"title":"Surface-based TBM boosts power to detect disease effects on the brain: an N=804 ADNI study","title_match":false,"year":2011},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/mapping-progressive-brain-structural-changes-in-early-alzheimer-s-18395760","doi":"10.1016/j.neuropsychologia.2007.10.026","journal":"Neuropsychologia","n_participants":null,"pmid":"18395760","source_url":"https://pubmed.ncbi.nlm.nih.gov/18395760/","study_design":null,"title":"Mapping progressive brain structural changes in early Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2008},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/progression-of-mild-cognitive-impairment-to-dementia-a-challenge-to-17077428","doi":"10.1192/bjp.bp.105.014779","journal":"The British journal of psychiatry : the journal of mental science","n_participants":null,"pmid":"17077428","source_url":"https://pubmed.ncbi.nlm.nih.gov/17077428/","study_design":null,"title":"Progression of mild cognitive impairment to dementia: a challenge to current thinking","title_match":true,"year":2006},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/cholinergic-plasticity-in-hippocampus-of-individuals-with-mild-12590165","doi":"10.3233/jad-2003-5106","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"12590165","source_url":"https://pubmed.ncbi.nlm.nih.gov/12590165/","study_design":null,"title":"Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology","title_match":false,"year":2003},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/an-integrative-multi-omics-approach-reveals-new-central-nervous-33794997","doi":"10.1186/s13195-021-00814-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"33794997","source_url":"https://pubmed.ncbi.nlm.nih.gov/33794997/","study_design":null,"title":"An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/pharmacological-and-non-pharmacological-interventions-to-enhance-33289311","doi":"10.1111/jsr.13229","journal":"Journal of sleep research","n_participants":1056,"pmid":"33289311","source_url":"https://pubmed.ncbi.nlm.nih.gov/33289311/","study_design":"systematic review","title":"Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/nuclear-but-not-mitochondrial-encoded-oxidative-phosphorylation-genes-27793643","doi":"10.1016/j.jalz.2016.09.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"27793643","source_url":"https://pubmed.ncbi.nlm.nih.gov/27793643/","study_design":null,"title":"Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/molecular-and-cellular-pathophysiology-of-preclinical-alzheimer-s-27185734","doi":"10.1016/j.bbr.2016.05.030","journal":"Behavioural brain research","n_participants":null,"pmid":"27185734","source_url":"https://pubmed.ncbi.nlm.nih.gov/27185734/","study_design":null,"title":"Molecular and cellular pathophysiology of preclinical Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/predicting-the-risk-of-mild-cognitive-impairment-in-the-mayo-clinic-25788555","doi":"10.1212/wnl.0000000000001437","journal":"Neurology","n_participants":null,"pmid":"25788555","source_url":"https://pubmed.ncbi.nlm.nih.gov/25788555/","study_design":"cohort study","title":"Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/effect-of-brain-derived-neurotrophic-factor-val66met-polymorphism-and-20491609","doi":"10.3109/15622971003797241","journal":"The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry","n_participants":30,"pmid":"20491609","source_url":"https://pubmed.ncbi.nlm.nih.gov/20491609/","study_design":null,"title":"Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment","title_match":true,"year":2010},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/why-do-so-many-drugs-for-alzheimer-s-disease-fail-in-development-time-18953116","doi":"10.3233/jad-2008-15213","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"18953116","source_url":"https://pubmed.ncbi.nlm.nih.gov/18953116/","study_design":null,"title":"Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/patients-with-mci-and-n400-or-p600-abnormalities-are-at-very-high-18077800","doi":"10.1212/01.wnl.0000281689.28759.ab","journal":"Neurology","n_participants":32,"pmid":"18077800","source_url":"https://pubmed.ncbi.nlm.nih.gov/18077800/","study_design":null,"title":"Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia","title_match":true,"year":2008},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/mri-of-hippocampus-and-entorhinal-cortex-in-mild-cognitive-impairment-17097769","doi":"10.1016/j.neurobiolaging.2006.09.007","journal":"Neurobiology of aging","n_participants":60,"pmid":"17097769","source_url":"https://pubmed.ncbi.nlm.nih.gov/17097769/","study_design":null,"title":"MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study","title_match":false,"year":2008},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/thinner-changes-of-the-retinal-nerve-fiber-layer-in-patients-with-25886372","doi":"10.1186/s12883-015-0268-6","journal":"BMC neurology","n_participants":null,"pmid":"25886372","source_url":"https://pubmed.ncbi.nlm.nih.gov/25886372/","study_design":null,"title":"Thinner changes of the retinal nerve fiber layer in patients with mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/quantitative-electroencephalogram-utility-in-predicting-conversion-of-25129239","doi":"10.1016/j.neurobiolaging.2014.07.009","journal":"Neurobiology of aging","n_participants":20,"pmid":"25129239","source_url":"https://pubmed.ncbi.nlm.nih.gov/25129239/","study_design":null,"title":"Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies","title_match":true,"year":2015},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/depression-in-mild-cognitive-impairment-is-associated-with-25024328","doi":"10.3233/jad-140405","journal":"Journal of Alzheimer's disease : JAD","n_participants":74,"pmid":"25024328","source_url":"https://pubmed.ncbi.nlm.nih.gov/25024328/","study_design":"longitudinal study","title":"Depression in mild cognitive impairment is associated with progression to Alzheimer's disease: a longitudinal study","title_match":true,"year":2014},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/ifn-and-tnf-are-involved-during-alzheimer-disease-progression-and-24831467","doi":"10.1089/jir.2013.0085","journal":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","n_participants":25,"pmid":"24831467","source_url":"https://pubmed.ncbi.nlm.nih.gov/24831467/","study_design":null,"title":"IFN-\u03b3 and TNF-\u03b1 are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients","title_match":false,"year":2014},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/redox-proteomic-analysis-of-carbonylated-brain-proteins-in-mild-19686046","doi":"10.1089/ars.2009.2810","journal":"Antioxidants & redox signaling","n_participants":null,"pmid":"19686046","source_url":"https://pubmed.ncbi.nlm.nih.gov/19686046/","study_design":null,"title":"Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/facial-emotion-recognition-deficit-in-amnestic-mild-cognitive-18403572","doi":"10.1097/jgp.0b013e318165dbce","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"18403572","source_url":"https://pubmed.ncbi.nlm.nih.gov/18403572/","study_design":"case-control study","title":"Facial emotion recognition deficit in amnestic mild cognitive impairment and Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/redox-proteomics-identification-of-oxidatively-modified-brain-17851195","doi":"10.3233/jad-2007-12107","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"17851195","source_url":"https://pubmed.ncbi.nlm.nih.gov/17851195/","study_design":null,"title":"Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder","title_match":true,"year":2007},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/associations-of-hippocampal-subfields-in-the-progression-of-cognitive-28116240","doi":"10.1016/j.nicl.2016.12.008","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"28116240","source_url":"https://pubmed.ncbi.nlm.nih.gov/28116240/","study_design":null,"title":"Associations of hippocampal subfields in the progression of cognitive decline related to Parkinson's disease","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/reliability-of-two-dimensional-and-three-dimensional-pseudo-24038544","doi":"10.1002/jmri.24246","journal":"Journal of magnetic resonance imaging : JMRI","n_participants":null,"pmid":"24038544","source_url":"https://pubmed.ncbi.nlm.nih.gov/24038544/","study_design":"longitudinal study","title":"Reliability of two-dimensional and three-dimensional pseudo-continuous arterial spin labeling perfusion MRI in elderly populations: comparison with 15O-water positron emission tomography","title_match":false,"year":2014},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-role-of-event-related-potentials-in-cognitive-decline-in-20005164","doi":"10.1016/j.clinph.2009.11.001","journal":"Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology","n_participants":null,"pmid":"20005164","source_url":"https://pubmed.ncbi.nlm.nih.gov/20005164/","study_design":"longitudinal study","title":"The role of event-related potentials in cognitive decline in Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/voxel-based-morphometry-to-detect-brain-atrophy-in-progressive-mild-17683950","doi":"10.1016/j.neuroimage.2007.06.016","journal":"NeuroImage","n_participants":13,"pmid":"17683950","source_url":"https://pubmed.ncbi.nlm.nih.gov/17683950/","study_design":null,"title":"Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/longitudinal-mri-findings-from-the-vitamin-e-and-donepezil-treatment-17452062","doi":"10.1016/j.neurobiolaging.2007.03.004","journal":"Neurobiology of aging","n_participants":131,"pmid":"17452062","source_url":"https://pubmed.ncbi.nlm.nih.gov/17452062/","study_design":null,"title":"Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/preclinical-alzheimer-s-disease-diagnosis-and-prediction-of-16109364","doi":"10.1016/s1474-4422(05)70168-x","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16109364","source_url":"https://pubmed.ncbi.nlm.nih.gov/16109364/","study_design":"longitudinal study","title":"Preclinical Alzheimer's disease: diagnosis and prediction of progression","title_match":false,"year":2005},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/subjective-cognitive-decline-as-a-predictor-of-future-cognitive-32973979","doi":"10.1590/1980-57642020dn14-030007","journal":"Dementia & neuropsychologia","n_participants":null,"pmid":"32973979","source_url":"https://pubmed.ncbi.nlm.nih.gov/32973979/","study_design":"systematic review","title":"Subjective cognitive decline as a predictor of future cognitive decline: a systematic review","title_match":false,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/progression-of-grey-and-white-matter-brain-damage-in-parkinson-s-32378035","doi":"10.1007/s00415-020-09863-8","journal":"Journal of neurology","n_participants":null,"pmid":"32378035","source_url":"https://pubmed.ncbi.nlm.nih.gov/32378035/","study_design":"longitudinal study","title":"Progression of grey and white matter brain damage in Parkinson's disease: a critical review of structural MRI literature","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/increased-plasma-beta-secretase-1-may-predict-conversion-to-alzheimer-28359566","doi":"10.1016/j.biopsych.2017.02.007","journal":"Biological psychiatry","n_participants":96,"pmid":"28359566","source_url":"https://pubmed.ncbi.nlm.nih.gov/28359566/","study_design":null,"title":"Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment","title_match":true,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/olfactory-impairment-predicts-cognitive-decline-in-early-parkinson-s-26923521","doi":"10.1016/j.parkreldis.2016.02.013","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"26923521","source_url":"https://pubmed.ncbi.nlm.nih.gov/26923521/","study_design":"cross-sectional","title":"Olfactory impairment predicts cognitive decline in early Parkinson's disease","title_match":false,"year":2016},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/progression-of-mild-cognitive-impairment-to-dementia-due-to-ad-in-26136516","doi":"10.1212/wnl.0000000000001788","journal":"Neurology","n_participants":446439,"pmid":"26136516","source_url":"https://pubmed.ncbi.nlm.nih.gov/26136516/","study_design":"cohort study","title":"Progression of mild cognitive impairment to dementia due to AD in clinical settings","title_match":true,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/relation-between-subcortical-grey-matter-atrophy-and-conversion-from-25904810","doi":"10.1136/jnnp-2014-309105","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":773,"pmid":"25904810","source_url":"https://pubmed.ncbi.nlm.nih.gov/25904810/","study_design":null,"title":"Relation between subcortical grey matter atrophy and conversion from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2016},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/cholinesterase-inhibitors-for-mild-cognitive-impairment-22972133","doi":"10.1002/14651858.cd009132.pub2","journal":"The Cochrane database of systematic reviews","n_participants":5149,"pmid":"22972133","source_url":"https://pubmed.ncbi.nlm.nih.gov/22972133/","study_design":"meta-analysis","title":"Cholinesterase inhibitors for mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/does-lithium-prevent-alzheimer-s-disease-22500970","doi":"10.2165/11599180-000000000-00000","journal":"Drugs & aging","n_participants":null,"pmid":"22500970","source_url":"https://pubmed.ncbi.nlm.nih.gov/22500970/","study_design":null,"title":"Does lithium prevent Alzheimer's disease?","title_match":false,"year":2012},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/dynamic-changes-in-pet-amyloid-and-fdg-imaging-at-different-stages-of-20688420","doi":"10.1016/j.neurobiolaging.2010.06.015","journal":"Neurobiology of aging","n_participants":null,"pmid":"20688420","source_url":"https://pubmed.ncbi.nlm.nih.gov/20688420/","study_design":null,"title":"Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/harnessing-peripheral-dna-methylation-differences-in-the-alzheimer-s-32539856","doi":"10.1186/s13148-020-00864-y","journal":"Clinical epigenetics","n_participants":653,"pmid":"32539856","source_url":"https://pubmed.ncbi.nlm.nih.gov/32539856/","study_design":"longitudinal study","title":"Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease","title_match":false,"year":2020},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/soluble-trem2-changes-during-the-clinical-course-of-alzheimer-s-30171911","doi":"10.1016/j.neulet.2018.08.038","journal":"Neuroscience letters","n_participants":82,"pmid":"30171911","source_url":"https://pubmed.ncbi.nlm.nih.gov/30171911/","study_design":"meta-analysis","title":"Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis","title_match":false,"year":2018},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/plcg2-protective-variant-p-p522r-modulates-tau-pathology-and-disease-32166339","doi":"10.1007/s00401-020-02138-6","journal":"Acta neuropathologica","n_participants":10097,"pmid":"32166339","source_url":"https://pubmed.ncbi.nlm.nih.gov/32166339/","study_design":"longitudinal study","title":"PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment","title_match":true,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/soluble-trem2-levels-associate-with-conversion-from-mild-cognitive-36519540","doi":"10.1172/jci158708","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"36519540","source_url":"https://pubmed.ncbi.nlm.nih.gov/36519540/","study_design":null,"title":"Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuroinflammatory-biomarkers-in-alzheimer-s-disease-from-39596011","doi":"10.3390/ijms252211941","journal":"International journal of molecular sciences","n_participants":null,"pmid":"39596011","source_url":"https://pubmed.ncbi.nlm.nih.gov/39596011/","study_design":null,"title":"Neuroinflammatory Biomarkers in Alzheimer's Disease: From Pathophysiology to Clinical Implications","title_match":false,"year":2024},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/increased-expression-of-trem2-in-peripheral-cells-from-mild-cognitive-29377401","doi":"10.1111/ene.13583","journal":"European journal of neurology","n_participants":null,"pmid":"29377401","source_url":"https://pubmed.ncbi.nlm.nih.gov/29377401/","study_design":null,"title":"Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease","title_match":true,"year":2018},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-levels-of-amyloid-1-42-but-not-of-tau-are-fully-22213792","doi":"10.1001/archgenpsychiatry.2011.155","journal":"Archives of general psychiatry","n_participants":137,"pmid":"22213792","source_url":"https://pubmed.ncbi.nlm.nih.gov/22213792/","study_design":null,"title":"Cerebrospinal fluid levels of \u03b2-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia","title_match":false,"year":2012},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/utility-of-combinations-of-biomarkers-cognitive-markers-and-risk-21893661","doi":"10.1001/archgenpsychiatry.2011.96","journal":"Archives of general psychiatry","n_participants":116,"pmid":"21893661","source_url":"https://pubmed.ncbi.nlm.nih.gov/21893661/","study_design":"longitudinal study","title":"Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer's disease neuroimaging initiative","title_match":true,"year":2011},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/biomarkers-as-predictors-for-conversion-from-mild-cognitive-20413876","doi":"10.3233/jad-2010-091606","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20413876","source_url":"https://pubmed.ncbi.nlm.nih.gov/20413876/","study_design":"meta-analysis","title":"Biomarkers as predictors for conversion from mild cognitive impairment to Alzheimer-type dementia: implications for trial design","title_match":true,"year":2010},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/progression-of-subjective-cognitive-decline-to-mci-or-dementia-in-36028322","doi":"10.1212/wnl.0000000000201072","journal":"Neurology","n_participants":null,"pmid":"36028322","source_url":"https://pubmed.ncbi.nlm.nih.gov/36028322/","study_design":"meta-analysis","title":"Progression of Subjective Cognitive Decline to MCI or Dementia in Relation to Biomarkers for Alzheimer Disease: A Meta-analysis","title_match":true,"year":2022},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/acceleration-of-brain-atrophy-and-progression-from-normal-cognition-39476236","doi":"10.1001/jamanetworkopen.2024.41505","journal":"JAMA network open","n_participants":185,"pmid":"39476236","source_url":"https://pubmed.ncbi.nlm.nih.gov/39476236/","study_design":"cohort study","title":"Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/progression-to-dementia-in-memory-clinic-patients-with-mild-cognitive-31805990","doi":"10.1186/s13195-019-0557-1","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"31805990","source_url":"https://pubmed.ncbi.nlm.nih.gov/31805990/","study_design":null,"title":"Progression to dementia in memory clinic patients with mild cognitive impairment and normal \u03b2-amyloid","title_match":true,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-profiles-and-prospective-course-and-outcome-in-21220682","doi":"10.1001/archneurol.2010.334","journal":"Archives of neurology","n_participants":null,"pmid":"21220682","source_url":"https://pubmed.ncbi.nlm.nih.gov/21220682/","study_design":null,"title":"Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment","title_match":false,"year":2011},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/relevance-of-minor-neuropsychological-deficits-in-patients-with-37821235","doi":"10.1212/wnl.0000000000207844","journal":"Neurology","n_participants":672,"pmid":"37821235","source_url":"https://pubmed.ncbi.nlm.nih.gov/37821235/","study_design":"longitudinal study","title":"Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/csf-tau-and-amyloid-as-biomarkers-for-mild-cognitive-impairment-22034251","doi":null,"journal":"Dialogues in clinical neuroscience","n_participants":null,"pmid":"22034251","source_url":"https://pubmed.ncbi.nlm.nih.gov/22034251/","study_design":null,"title":"CSF tau and \u03b2-amyloid as biomarkers for mild cognitive impairment","title_match":false,"year":2004},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-a42-a40-and-p-tau181-predict-long-term-clinical-progression-in-36208187","doi":"10.1093/clinchem/hvac149","journal":"Clinical chemistry","n_participants":null,"pmid":"36208187","source_url":"https://pubmed.ncbi.nlm.nih.gov/36208187/","study_design":"longitudinal study","title":"Plasma A\u03b242/A\u03b240 and p-tau181 Predict Long-Term Clinical Progression in a Cohort with Amnestic Mild Cognitive Impairment","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/evidence-for-elevated-cerebrospinal-fluid-erk1-2-levels-in-alzheimer-22145083","doi":"10.4061/2011/739847","journal":"International journal of Alzheimer's disease","n_participants":33,"pmid":"22145083","source_url":"https://pubmed.ncbi.nlm.nih.gov/22145083/","study_design":null,"title":"Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia","title_match":false,"year":2011},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/progression-from-mild-to-pronounced-mci-is-not-associated-with-22057225","doi":"10.1159/000333034","journal":"Dementia and geriatric cognitive disorders","n_participants":161,"pmid":"22057225","source_url":"https://pubmed.ncbi.nlm.nih.gov/22057225/","study_design":null,"title":"Progression from mild to pronounced MCI is not associated with cerebrospinal fluid biomarker deviations","title_match":true,"year":2011},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/associations-of-plasma-smoc1-and-soluble-il6ra-levels-with-the-39640195","doi":"10.1016/j.bbih.2024.100899","journal":"Brain, behavior, & immunity - health","n_participants":485,"pmid":"39640195","source_url":"https://pubmed.ncbi.nlm.nih.gov/39640195/","study_design":null,"title":"Associations of plasma SMOC1 and soluble IL6RA levels with the progression from mild cognitive impairment to dementia","title_match":true,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-positive-mild-cognitive-impairment-clinical-and-34397597","doi":"10.1097/cm9.0000000000001496","journal":"Chinese medical journal","n_participants":64,"pmid":"34397597","source_url":"https://pubmed.ncbi.nlm.nih.gov/34397597/","study_design":null,"title":"Amyloid and tau positive mild cognitive impairment: clinical and biomarker characteristics of dementia progression","title_match":true,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/assessment-of-cerebrospinal-fluid-csf-beta-amyloid-1-42-21721431","doi":null,"journal":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","n_participants":null,"pmid":"21721431","source_url":"https://pubmed.ncbi.nlm.nih.gov/21721431/","study_design":"longitudinal study","title":"Assessment of cerebrospinal fluid (CSF) beta-amyloid (1-42), phosphorylated tau (ptau-181) and total Tau protein in patients with Alzheimer's disease (AD) and other dementia at Siriraj Hospital, Thailand","title_match":false,"year":2011},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/neuronorma-cognitive-battery-associations-with-cerebrospinal-fluid-37038810","doi":"10.3233/jad-220930","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"37038810","source_url":"https://pubmed.ncbi.nlm.nih.gov/37038810/","study_design":null,"title":"NEURONORMA Cognitive Battery Associations with Cerebrospinal Fluid Amyloid-\u03b2 and Tau Levels in the Continuum of Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/patients-with-mild-cognitive-impairment-and-a-reduced-csf-a142-21621878","doi":"10.1016/j.nrl.2011.03.014","journal":"Neurologia (Barcelona, Spain)","n_participants":36,"pmid":"21621878","source_url":"https://pubmed.ncbi.nlm.nih.gov/21621878/","study_design":null,"title":"[Patients with mild cognitive impairment and a reduced CSF A\u03b2\u2081\u208b\u2084\u2082 protein progress rapidly to Alzheimer's disease]","title_match":true,"year":2012},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/identification-of-a-simple-and-novel-cut-point-based-csf-and-mri-1622868e","doi":"10.1101/443325","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1101/443325","study_design":null,"title":"Identification of a simple and novel cut-point based CSF and MRI signature for predicting Alzheimer\u2019s disease progression that reinforces the 2018 NIA-AA research framework","title_match":false,"year":2018},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/current-and-evolving-treatment-strategies-for-the-alzheimer-disease-32840330","doi":"10.37765/ajmc.2020.88481","journal":"The American journal of managed care","n_participants":null,"pmid":"32840330","source_url":"https://pubmed.ncbi.nlm.nih.gov/32840330/","study_design":"clinical trial","title":"Current and evolving treatment strategies for the Alzheimer disease continuum","title_match":false,"year":2020},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/therapy-developments-in-alzheimer-s-disease-35588740","doi":"10.1055/a-1802-4837","journal":"Fortschritte der Neurologie-Psychiatrie","n_participants":null,"pmid":"35588740","source_url":"https://pubmed.ncbi.nlm.nih.gov/35588740/","study_design":null,"title":"[Therapy Developments in Alzheimer's Disease]","title_match":false,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/automated-3d-mapping-of-hippocampal-atrophy-and-its-clinical-19172649","doi":"10.1002/hbm.20708","journal":"Human brain mapping","n_participants":400,"pmid":"19172649","source_url":"https://pubmed.ncbi.nlm.nih.gov/19172649/","study_design":null,"title":"Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls","title_match":false,"year":2009},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/association-of-short-term-cognitive-decline-and-mci-to-ad-dementia-30927601","doi":"10.1016/j.nicl.2019.101771","journal":"NeuroImage. Clinical","n_participants":13,"pmid":"30927601","source_url":"https://pubmed.ncbi.nlm.nih.gov/30927601/","study_design":null,"title":"Association of short-term cognitive decline and MCI-to-AD dementia conversion with CSF, MRI, amyloid- and 18F-FDG-PET imaging","title_match":true,"year":2019},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-efficacy-and-safety-of-transcutaneous-auricular-vagus-nerve-36150665","doi":"10.1016/j.brs.2022.09.003","journal":"Brain stimulation","n_participants":52,"pmid":"36150665","source_url":"https://pubmed.ncbi.nlm.nih.gov/36150665/","study_design":"randomized controlled trial","title":"The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial","title_match":false,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/parafoveal-vessel-loss-and-correlation-between-peripapillary-vessel-30939178","doi":"10.1371/journal.pone.0214685","journal":"PloS one","n_participants":16,"pmid":"30939178","source_url":"https://pubmed.ncbi.nlm.nih.gov/30939178/","study_design":"case-control study","title":"Parafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer's Disease on optical coherence tomography angiography","title_match":false,"year":2019},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/longitudinal-change-in-cognitive-performance-among-individuals-with-17402816","doi":"10.1037/0894-4105.21.2.158","journal":"Neuropsychology","n_participants":33,"pmid":"17402816","source_url":"https://pubmed.ncbi.nlm.nih.gov/17402816/","study_design":"longitudinal study","title":"Longitudinal change in cognitive performance among individuals with mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/individualized-prognosis-of-cognitive-decline-and-dementia-in-mild-37117993","doi":"10.1038/s43587-020-00003-5","journal":"Nature aging","n_participants":573,"pmid":"37117993","source_url":"https://pubmed.ncbi.nlm.nih.gov/37117993/","study_design":"longitudinal study","title":"Individualized prognosis of cognitive decline and dementia in mild cognitive impairment based on plasma biomarker combinations","title_match":false,"year":2021},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/18f-fdg-pet-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-25629415","doi":"10.1002/14651858.cd010632.pub2","journal":"The Cochrane database of systematic reviews","n_participants":14,"pmid":"25629415","source_url":"https://pubmed.ncbi.nlm.nih.gov/25629415/","study_design":"meta-analysis","title":"\u00b9\u2078F-FDG PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/sparse-learning-and-stability-selection-for-predicting-mci-to-ad-22731740","doi":"10.1186/1471-2377-12-46","journal":"BMC neurology","n_participants":null,"pmid":"22731740","source_url":"https://pubmed.ncbi.nlm.nih.gov/22731740/","study_design":null,"title":"Sparse learning and stability selection for predicting MCI to AD conversion using baseline ADNI data","title_match":true,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/left-lateralized-cerebral-glucose-metabolism-declines-in-amyloid-30101060","doi":"10.1016/j.nicl.2018.07.016","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"30101060","source_url":"https://pubmed.ncbi.nlm.nih.gov/30101060/","study_design":"longitudinal study","title":"Left lateralized cerebral glucose metabolism declines in amyloid-\u03b2 positive persons with mild cognitive impairment","title_match":false,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/development-and-validation-of-language-and-visuospatial-composite-33313380","doi":"10.1002/trc2.12072","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"33313380","source_url":"https://pubmed.ncbi.nlm.nih.gov/33313380/","study_design":null,"title":"Development and validation of language and visuospatial composite scores in ADNI","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/evaluation-of-a-calibrated-18-f-fdg-pet-score-as-a-biomarker-for-21764801","doi":"10.2967/jnumed.111.090902","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":44,"pmid":"21764801","source_url":"https://pubmed.ncbi.nlm.nih.gov/21764801/","study_design":null,"title":"Evaluation of a calibrated (18)F-FDG PET score as a biomarker for progression in Alzheimer disease and mild cognitive impairment","title_match":true,"year":2011},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/independent-and-reproducible-hippocampal-radiomic-biomarkers-for-36659162","doi":"10.1016/j.scib.2020.04.003","journal":"Science bulletin","n_participants":261,"pmid":"36659162","source_url":"https://pubmed.ncbi.nlm.nih.gov/36659162/","study_design":"longitudinal study","title":"Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/spatial-temporal-dependency-modeling-and-network-hub-detection-for-31825859","doi":"10.1109/tbme.2019.2957921","journal":"IEEE transactions on bio-medical engineering","n_participants":174,"pmid":"31825859","source_url":"https://pubmed.ncbi.nlm.nih.gov/31825859/","study_design":null,"title":"Spatial-Temporal Dependency Modeling and Network Hub Detection for Functional MRI Analysis via Convolutional-Recurrent Network","title_match":false,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/neuronal-injury-biomarkers-and-prognosis-in-adni-subjects-with-normal-24602322","doi":"10.1186/2051-5960-2-26","journal":"Acta neuropathologica communications","n_participants":160,"pmid":"24602322","source_url":"https://pubmed.ncbi.nlm.nih.gov/24602322/","study_design":"cross-sectional","title":"Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition","title_match":false,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/spectrum-of-cognition-short-of-dementia-framingham-heart-study-and-26453643","doi":"10.1212/wnl.0000000000002100","journal":"Neurology","n_participants":null,"pmid":"26453643","source_url":"https://pubmed.ncbi.nlm.nih.gov/26453643/","study_design":null,"title":"Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/genetic-risk-of-neurodegenerative-diseases-is-associated-with-mild-25916564","doi":"10.1016/j.jalz.2014.12.008","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"25916564","source_url":"https://pubmed.ncbi.nlm.nih.gov/25916564/","study_design":null,"title":"Genetic risk of neurodegenerative diseases is associated with mild cognitive impairment and conversion to dementia","title_match":true,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-relative-importance-of-imaging-markers-for-the-prediction-of-26199870","doi":"10.1016/j.nicl.2015.05.006","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"26199870","source_url":"https://pubmed.ncbi.nlm.nih.gov/26199870/","study_design":null,"title":"The relative importance of imaging markers for the prediction of Alzheimer's disease dementia in mild cognitive impairment - Beyond classical regression","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/individual-brain-metabolic-connectome-indicator-based-on-kullback-32318784","doi":"10.1007/s00259-020-04814-x","journal":"European journal of nuclear medicine and molecular imaging","n_participants":332,"pmid":"32318784","source_url":"https://pubmed.ncbi.nlm.nih.gov/32318784/","study_design":null,"title":"Individual brain metabolic connectome indicator based on Kullback-Leibler Divergence Similarity Estimation predicts progression from mild cognitive impairment to Alzheimer's dementia","title_match":true,"year":2020},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/prediction-models-for-conversion-from-mild-cognitive-impairment-to-35493941","doi":"10.3389/fnagi.2022.840386","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"35493941","source_url":"https://pubmed.ncbi.nlm.nih.gov/35493941/","study_design":"systematic review","title":"Prediction Models for Conversion From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review and Meta-Analysis","title_match":true,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/latent-classes-of-neuropsychiatric-symptoms-in-nacc-controls-and-26402012","doi":"10.3233/jad-150421","journal":"Journal of Alzheimer's disease : JAD","n_participants":4517,"pmid":"26402012","source_url":"https://pubmed.ncbi.nlm.nih.gov/26402012/","study_design":null,"title":"Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia","title_match":true,"year":2015},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/longitudinal-plasma-phosphorylated-tau-181-tracks-disease-progression-34120152","doi":"10.1038/s41398-021-01476-7","journal":"Translational psychiatry","n_participants":1184,"pmid":"34120152","source_url":"https://pubmed.ncbi.nlm.nih.gov/34120152/","study_design":"longitudinal study","title":"Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/confirmatory-factor-analysis-of-the-adni-neuropsychological-battery-22777078","doi":"10.1007/s11682-012-9190-3","journal":"Brain imaging and behavior","n_participants":null,"pmid":"22777078","source_url":"https://pubmed.ncbi.nlm.nih.gov/22777078/","study_design":"longitudinal study","title":"Confirmatory factor analysis of the ADNI Neuropsychological Battery","title_match":false,"year":2012},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/generalizable-deep-learning-model-for-early-alzheimer-s-disease-36253382","doi":"10.1038/s41598-022-20674-x","journal":"Scientific reports","n_participants":null,"pmid":"36253382","source_url":"https://pubmed.ncbi.nlm.nih.gov/36253382/","study_design":null,"title":"Generalizable deep learning model for early Alzheimer's disease detection from structural MRIs","title_match":false,"year":2022},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/prediction-of-mild-cognitive-impairment-conversion-using-a-28220065","doi":"10.3389/fnhum.2017.00033","journal":"Frontiers in human neuroscience","n_participants":null,"pmid":"28220065","source_url":"https://pubmed.ncbi.nlm.nih.gov/28220065/","study_design":null,"title":"Prediction of Mild Cognitive Impairment Conversion Using a Combination of Independent Component Analysis and the Cox Model","title_match":true,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-level-predicts-neurodegeneration-and-progression-to-34557143","doi":"10.3389/fneur.2021.695696","journal":"Frontiers in neurology","n_participants":185,"pmid":"34557143","source_url":"https://pubmed.ncbi.nlm.nih.gov/34557143/","study_design":"cross-sectional","title":"Plasma p-tau181 Level Predicts Neurodegeneration and Progression to Alzheimer's Dementia: A Longitudinal Study","title_match":false,"year":2021},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/combined-plasma-and-cerebrospinal-fluid-signature-for-the-prediction-26659895","doi":"10.1001/jamaneurol.2015.3135","journal":"JAMA neurology","n_participants":928,"pmid":"26659895","source_url":"https://pubmed.ncbi.nlm.nih.gov/26659895/","study_design":"cohort study","title":"Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease","title_match":true,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/disease-progression-model-for-clinical-dementia-rating-sum-of-boxes-24926196","doi":"10.2147/ndt.s62323","journal":"Neuropsychiatric disease and treatment","n_participants":null,"pmid":"24926196","source_url":"https://pubmed.ncbi.nlm.nih.gov/24926196/","study_design":"longitudinal study","title":"Disease progression model for Clinical Dementia Rating-Sum of Boxes in mild cognitive impairment and Alzheimer's subjects from the Alzheimer's Disease Neuroimaging Initiative","title_match":true,"year":2014},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/multi-view-separable-pyramid-network-for-ad-prediction-at-mci-stage-32894711","doi":"10.1109/tmi.2020.3022591","journal":"IEEE transactions on medical imaging","n_participants":null,"pmid":"32894711","source_url":"https://pubmed.ncbi.nlm.nih.gov/32894711/","study_design":null,"title":"Multi-View Separable Pyramid Network for AD Prediction at MCI Stage by 18F-FDG Brain PET Imaging","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/optimization-of-statistical-single-subject-analysis-of-brain-fdg-pet-26577523","doi":"10.3233/jad-150814","journal":"Journal of Alzheimer's disease : JAD","n_participants":77,"pmid":"26577523","source_url":"https://pubmed.ncbi.nlm.nih.gov/26577523/","study_design":null,"title":"Optimization of Statistical Single Subject Analysis of Brain FDG PET for the Prognosis of Mild Cognitive Impairment-to-Alzheimer's Disease Conversion","title_match":true,"year":2016},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/modelling-prognostic-trajectories-of-cognitive-decline-due-to-32106025","doi":"10.1016/j.nicl.2020.102199","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"32106025","source_url":"https://pubmed.ncbi.nlm.nih.gov/32106025/","study_design":null,"title":"Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/enrichment-through-biomarkers-in-clinical-trials-of-alzheimer-s-drugs-20541287","doi":"10.1016/j.neurobiolaging.2010.04.036","journal":"Neurobiology of aging","n_participants":null,"pmid":"20541287","source_url":"https://pubmed.ncbi.nlm.nih.gov/20541287/","study_design":null,"title":"Enrichment through biomarkers in clinical trials of Alzheimer's drugs in patients with mild cognitive impairment","title_match":false,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/inferior-and-medial-temporal-tau-and-cortical-amyloid-are-associated-30704519","doi":"10.1186/s13195-019-0471-6","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"30704519","source_url":"https://pubmed.ncbi.nlm.nih.gov/30704519/","study_design":"cross-sectional","title":"Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/studying-ventricular-abnormalities-in-mild-cognitive-impairment-with-25285374","doi":"10.1016/j.neuroimage.2014.09.062","journal":"NeuroImage","n_participants":null,"pmid":"25285374","source_url":"https://pubmed.ncbi.nlm.nih.gov/25285374/","study_design":null,"title":"Studying ventricular abnormalities in mild cognitive impairment with hyperbolic Ricci flow and tensor-based morphometry","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/combining-polygenic-hazard-score-with-volumetric-mri-and-cognitive-29760643","doi":"10.3389/fnins.2018.00260","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"29760643","source_url":"https://pubmed.ncbi.nlm.nih.gov/29760643/","study_design":null,"title":"Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease","title_match":true,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/automated-analysis-of-fdg-pet-as-a-tool-for-single-subject-23715905","doi":"10.1007/s00259-013-2458-z","journal":"European journal of nuclear medicine and molecular imaging","n_participants":36,"pmid":"23715905","source_url":"https://pubmed.ncbi.nlm.nih.gov/23715905/","study_design":null,"title":"Automated analysis of FDG PET as a tool for single-subject probabilistic prediction and detection of Alzheimer's disease dementia","title_match":false,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/practical-recommendations-for-timely-accurate-diagnosis-of-33458891","doi":"10.1111/joim.13244","journal":"Journal of internal medicine","n_participants":null,"pmid":"33458891","source_url":"https://pubmed.ncbi.nlm.nih.gov/33458891/","study_design":null,"title":"Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/association-of-brain-amyloid-with-cerebral-perfusion-and-structure-in-24625697","doi":"10.1093/brain/awu043","journal":"Brain : a journal of neurology","n_participants":51,"pmid":"24625697","source_url":"https://pubmed.ncbi.nlm.nih.gov/24625697/","study_design":null,"title":"Association of brain amyloid-\u03b2 with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2014},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-multimodal-machine-learning-model-for-predicting-dementia-38806509","doi":"10.1038/s41598-024-60134-2","journal":"Scientific Reports","n_participants":196,"pmid":"38806509","source_url":"https://pubmed.ncbi.nlm.nih.gov/38806509/","study_design":null,"title":"A multimodal machine learning model for predicting dementia conversion in Alzheimer\u2019s disease","title_match":false,"year":2024},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/f40105-racial-and-ethnic-differences-in-amyloid-pet-positivity-in-the-107a9626","doi":"10.1016/j.jalz.2019.06.4717","journal":"Alzheimer s & Dementia","n_participants":18550,"pmid":null,"source_url":"https://doi.org/10.1016/j.jalz.2019.06.4717","study_design":null,"title":"F4\u201001\u201005: RACIAL AND ETHNIC DIFFERENCES IN AMYLOID PET POSITIVITY IN THE IDEAS STUDY","title_match":false,"year":2019},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/association-of-neighborhood-socioeconomic-disadvantage-and-cognitive-35666244","doi":"10.1002/alz.12702","journal":"Alzheimer s & Dementia","n_participants":4699,"pmid":"35666244","source_url":"https://pubmed.ncbi.nlm.nih.gov/35666244/","study_design":null,"title":"Association of neighborhood socioeconomic disadvantage and cognitive impairment","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/modeling-early-detection-and-geographic-variation-in-health-system-9ba6d8b3","doi":"10.1002/alz.089739","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1002/alz.089739","study_design":null,"title":"Modeling Early Detection and Geographic Variation in Health System Capacity for Alzheimer\u2019s Disease\u2010Modifying Therapies","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/mayo-normative-studies-regressionbased-normative-data-for-remote-6d09a656","doi":"10.1002/alz.094197","journal":"Alzheimer s & Dementia","n_participants":167,"pmid":null,"source_url":"https://doi.org/10.1002/alz.094197","study_design":null,"title":"Mayo Normative Studies: regression\u2010based normative data for remote self\u2010administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite for ages 33\u2010100 and validation in MCI and dementia","title_match":false,"year":2024},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/mayo-normative-studies-regressionbased-normative-data-for-remote-39750656","doi":"10.1002/alz.085612","journal":"Alzheimer s & Dementia","n_participants":167,"pmid":"39750656","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11709812/","study_design":null,"title":"Mayo Normative Studies: regression\u2010based normative data for remote self\u2010administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite for ages 33\u2010100 and validation in MCI and dementia","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/instrumental-activities-of-daily-living-in-older-adults-with-epilepsy-42369457","doi":"10.1002/epi.70478","journal":"Epilepsia","n_participants":22,"pmid":"42369457","source_url":"https://pubmed.ncbi.nlm.nih.gov/42369457/","study_design":"longitudinal study","title":"Instrumental activities of daily living in older adults with epilepsy: A cross\u2010sectional and longitudinal multicenter study","title_match":false,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/combination-of-amyloid-and-fdg-pet-for-the-prediction-of-short-term-40257609","doi":"10.1007/s00259-025-07275-2","journal":"European Journal of Nuclear Medicine and Molecular Imaging","n_participants":145,"pmid":"40257609","source_url":"https://pubmed.ncbi.nlm.nih.gov/40257609/","study_design":null,"title":"Combination of amyloid and FDG PET for the prediction of short-term conversion from MCI to Alzheimer\u00b4s disease in the clinical practice","title_match":true,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-polygenic-risk-score-for-5-diseases-with-alzheimer-39836940","doi":"10.1212/wnl.0000000000210250","journal":"Neurology","n_participants":752,"pmid":"39836940","source_url":"https://pubmed.ncbi.nlm.nih.gov/39836940/","study_design":"prospective cohort","title":"Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/comparative-prognostic-performance-of-hippocampal-volume-and-plasma-42683796","doi":"10.3988/jcn.2025.0659","journal":"Journal of Clinical Neurology","n_participants":null,"pmid":"42683796","source_url":"https://pubmed.ncbi.nlm.nih.gov/42683796/","study_design":null,"title":"Comparative Prognostic Performance of Hippocampal Volume and Plasma Biomarkers in Amyloid-Negative Subjective Cognitive Decline: A Four-Year Follow-up","title_match":false,"year":2026},{"alzhub_score":29,"alzhub_url":"https://alzhub.org/study/pet-imaging-in-alzheimer-disease-diagnostic-and-prognostic-05f30011","doi":"10.66590/ijcmr2026030107","journal":"International Journal of Clinical and Medical Research","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.66590/ijcmr2026030107","study_design":null,"title":"PET Imaging in Alzheimer Disease: Diagnostic and Prognostic Applications","title_match":false,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/alzheimer-mimicry-late-and-part-40164861","doi":"10.1007/s00702-025-02916-0","journal":"Journal of Neural Transmission","n_participants":null,"pmid":"40164861","source_url":"https://pubmed.ncbi.nlm.nih.gov/40164861/","study_design":null,"title":"Alzheimer mimicry: LATE and PART","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/predicting-alzheimer-progression-using-eeg-based-digital-twins-4670ee3a","doi":"10.1038/s41746-026-02997-5","journal":"npj Digital Medicine","n_participants":459,"pmid":null,"source_url":"https://doi.org/10.1038/s41746-026-02997-5","study_design":null,"title":"Predicting Alzheimer progression using EEG-based digital twins","title_match":false,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/long-term-surveillance-of-the-anti-amyloid-monoclonal-antibody-40217276","doi":"10.1186/s13195-025-01699-6","journal":"Alzheimer s Research & Therapy","n_participants":null,"pmid":"40217276","source_url":"https://pubmed.ncbi.nlm.nih.gov/40217276/","study_design":null,"title":"Long-term surveillance of the anti-amyloid monoclonal antibody lecanemab: rights and duties of pharmacovigilance","title_match":false,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/lecanemab-donanemab-and-emerging-disease-modifying-therapies-for-d453d052","doi":"10.5281/zenodo.17615265","journal":"International Journal of Science and Research Archive","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.17615265","study_design":"narrative review","title":"Lecanemab, Donanemab, and Emerging Disease Modifying Therapies for Alzheimer Disease: Clinical Evidence and Primary Care Implications in Canada","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lecanemab-donanemab-and-emerging-disease-modifying-therapies-for-08ace6f7","doi":"10.5281/zenodo.17615266","journal":"International Journal of Science and Research Archive","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.17615266","study_design":"narrative review","title":"Lecanemab, Donanemab, and Emerging Disease Modifying Therapies for Alzheimer Disease: Clinical Evidence and Primary Care Implications in Canada","title_match":false,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/lecanemab-donanemab-and-emerging-disease-modifying-therapies-for-1b2f6657","doi":"10.30574/ijsra.2025.17.1.2929","journal":"International Journal of Science and Research Archive","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.30574/ijsra.2025.17.1.2929","study_design":"narrative review","title":"Lecanemab, Donanemab, and Emerging Disease Modifying Therapies for Alzheimer Disease: Clinical Evidence and Primary Care Implications in Canada","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/lecanemab-leqembi-25dfc5ad","doi":"10.51731/cjht.2026.1514","journal":"Canadian Journal of Health Technologies","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.51731/cjht.2026.1514","study_design":null,"title":"Lecanemab (Leqembi)","title_match":false,"year":2026},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/endogenous-lithium-levels-and-alzheimer-disease-41784383","doi":"10.1093/clinchem/hvaf174","journal":"Clinical Chemistry","n_participants":null,"pmid":"41784383","source_url":"https://pubmed.ncbi.nlm.nih.gov/41784383/","study_design":null,"title":"Endogenous Lithium Levels and Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/lifestyle-interventions-for-dementia-risk-reduction-a-review-on-the-39863321","doi":"10.1016/j.tjpad.2024.100028","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":null,"pmid":"39863321","source_url":"https://pubmed.ncbi.nlm.nih.gov/39863321/","study_design":null,"title":"Lifestyle interventions for dementia risk reduction: A review on the role of physical activity and diet in Western and Asian Countries","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/factors-associated-with-dementia-risk-reduction-lifestyle-in-mild-40247174","doi":"10.1186/s12883-025-04183-8","journal":"BMC Neurology","n_participants":302,"pmid":"40247174","source_url":"https://pubmed.ncbi.nlm.nih.gov/40247174/","study_design":null,"title":"Factors associated with dementia risk reduction lifestyle in mild cognitive impairment: a cross-sectional study of individuals and their family caregivers","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/revisiting-the-montreal-cognitive-assessment-in-a-european-cohort-of-40025711","doi":"10.1177/13872877251318029","journal":"Journal of Alzheimer s Disease","n_participants":128,"pmid":"40025711","source_url":"https://pubmed.ncbi.nlm.nih.gov/40025711/","study_design":"cohort study","title":"Revisiting the Montreal Cognitive Assessment in a European cohort of elderly living with type 2 diabetes","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/sensitivity-and-specificity-of-the-cantab-paired-associates-learning-42567065","doi":"10.1016/j.actpsy.2026.107597","journal":"Acta Psychologica","n_participants":null,"pmid":"42567065","source_url":"https://pubmed.ncbi.nlm.nih.gov/42567065/","study_design":null,"title":"Sensitivity and specificity of the CANTAB Paired Associates Learning test for identifying mild cognitive impairment","title_match":false,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/neuropsychological-tests-and-machine-learning-identifying-predictors-40072711","doi":"10.1007/s40520-025-02962-4","journal":"Aging Clinical and Experimental Research","n_participants":281,"pmid":"40072711","source_url":"https://pubmed.ncbi.nlm.nih.gov/40072711/","study_design":null,"title":"Neuropsychological tests and machine learning: identifying predictors of MCI and dementia progression","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cognitive-trajectories-from-preclinical-alzheimer-s-disease-to-41910174","doi":"10.1002/advs.202518124","journal":"Advanced Science","n_participants":1447,"pmid":"41910174","source_url":"https://pubmed.ncbi.nlm.nih.gov/41910174/","study_design":null,"title":"Cognitive Trajectories from Preclinical Alzheimer's Disease to Dementia","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/ai-driven-magnetoencephalography-biomarkers-in-dementia-risk-42022294","doi":"10.3389/frdem.2026.1743627","journal":"Frontiers in Dementia","n_participants":null,"pmid":"42022294","source_url":"https://pubmed.ncbi.nlm.nih.gov/42022294/","study_design":null,"title":"AI-driven magnetoencephalography biomarkers in dementia risk prediction: current evidence, challenges and future perspectives","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/converting-short-cognitive-screen-scores-comparing-the-quick-mild-58bdbb81","doi":"10.1177/25424823261441514","journal":"Journal of Alzheimer s Disease Reports","n_participants":101,"pmid":null,"source_url":"https://doi.org/10.1177/25424823261441514","study_design":null,"title":"Converting short cognitive screen scores: Comparing the Quick mild cognitive impairment screen, Montreal cognitive assessment, and Mini-mental state examination","title_match":true,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/connectivity-related-to-major-brain-functions-in-alzheimer-disease-40106095","doi":"10.1186/s41747-025-00570-5","journal":"European Radiology Experimental","n_participants":null,"pmid":"40106095","source_url":"https://pubmed.ncbi.nlm.nih.gov/40106095/","study_design":null,"title":"Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI","title_match":false,"year":2025},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/frequency-and-clinical-outcomes-associated-with-tau-positron-emission-40522652","doi":"10.1001/jama.2025.7817","journal":"JAMA","n_participants":6514,"pmid":"40522652","source_url":"https://pubmed.ncbi.nlm.nih.gov/40522652/","study_design":"longitudinal study","title":"Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/classification-method-based-on-surf-and-sift-features-for-alzheimer-40118994","doi":"10.1038/s41598-025-92759-2","journal":"Scientific Reports","n_participants":35,"pmid":"40118994","source_url":"https://pubmed.ncbi.nlm.nih.gov/40118994/","study_design":null,"title":"Classification method based on surf and sift features for alzheimer diagnosis using diffusion tensor magnetic resonance imaging","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/personalized-brain-models-link-cognitive-decline-progression-to-40188185","doi":"10.1186/s13195-025-01718-6","journal":"Alzheimer s Research & Therapy","n_participants":145,"pmid":"40188185","source_url":"https://pubmed.ncbi.nlm.nih.gov/40188185/","study_design":null,"title":"Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/longitudinal-structural-mri-based-deep-learning-and-radiomics-4f4d861f","doi":"10.5281/zenodo.18620943","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.18620943","study_design":"longitudinal study","title":"Longitudinal Structural MRI-Based Deep Learning And Radiomics Features For Predicting Alzheimer\\\\\\\\\\\\\\'s Disease Progression","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/longitudinal-structural-mri-based-deep-learning-and-radiomics-612ec977","doi":"10.5281/zenodo.18620944","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.18620944","study_design":"longitudinal study","title":"Longitudinal Structural MRI-Based Deep Learning And Radiomics Features For Predicting Alzheimer\\\\\\\\\\\\\\'s Disease Progression","title_match":false,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/late-life-body-mass-index-and-alzheimer-disease-conversion-in-mild-41856052","doi":"10.1016/j.archger.2026.106217","journal":"Archives of Gerontology and Geriatrics","n_participants":762,"pmid":"41856052","source_url":"https://pubmed.ncbi.nlm.nih.gov/41856052/","study_design":null,"title":"Late-life body mass index and Alzheimer disease conversion in mild cognitive impairment: Nonlinear risk and structural MRI correlates","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-clinical-prognosis-of-cognitively-unimpaired-individuals-with-41439799","doi":"10.1002/alz70856_096588","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41439799","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12729469/","study_design":"cohort study","title":"The clinical prognosis of cognitively unimpaired individuals with positive PET biomarkers","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/role-of-radio-diagnosis-in-early-detection-of-alzheimers-disease-a-792511ca","doi":"10.21474/ijar01/20861","journal":"International Journal of Advanced Research","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21474/ijar01/20861","study_design":"systematic review","title":"ROLE OF RADIO DIAGNOSIS IN EARLY DETECTION OF ALZHEIMERS DISEASE:A SYSTEMATIC REVIEW","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-permeability-changes-and-neuroinflammation-in-d2dc63f3","doi":"10.33545/26649926.2025.v7.i6g.778","journal":"International Journal of Biology Sciences","n_participants":94,"pmid":null,"source_url":"https://doi.org/10.33545/26649926.2025.v7.i6g.778","study_design":null,"title":"Blood-brain barrier permeability changes and neuroinflammation in Alzheimer disease progression","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/informing-etiological-heterogeneity-of-mild-cognitive-impairment-and-39800468","doi":"10.1016/j.tjpad.2024.100011","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":104,"pmid":"39800468","source_url":"https://pubmed.ncbi.nlm.nih.gov/39800468/","study_design":"cross-sectional","title":"Informing etiological heterogeneity of mild cognitive impairment and risk for progression to dementia with plasma p-tau217","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/predictors-of-transition-from-mild-cognitive-impairment-to-normal-41301354","doi":"10.3390/bs15111552","journal":"Behavioral Sciences","n_participants":272,"pmid":"41301354","source_url":"https://pubmed.ncbi.nlm.nih.gov/41301354/","study_design":null,"title":"Predictors of Transition from Mild Cognitive Impairment to Normal Cognition and Dementia","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/racial-disparities-in-the-association-of-epigenetic-age-acceleration-e1ea9586","doi":"10.1016/j.glt.2025.08.001","journal":"Global Transitions","n_participants":2671,"pmid":null,"source_url":"https://doi.org/10.1016/j.glt.2025.08.001","study_design":null,"title":"Racial disparities in the association of epigenetic age acceleration with the transition between normal cognition, mild cognitive impairment and dementia","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-biomarkers-for-diagnosis-and-prediction-of-40133253","doi":"10.1038/s41467-025-56756-3","journal":"Nature Communications","n_participants":49,"pmid":"40133253","source_url":"https://pubmed.ncbi.nlm.nih.gov/40133253/","study_design":"cohort study","title":"Performance of plasma biomarkers for diagnosis and prediction of dementia in a Brazilian cohort","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/associations-between-traumatic-brain-injury-and-the-prevalence-of-40883139","doi":"10.1016/j.tjpad.2025.100360","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":452718,"pmid":"40883139","source_url":"https://pubmed.ncbi.nlm.nih.gov/40883139/","study_design":"cohort study","title":"Associations between traumatic brain injury and the prevalence of Alzheimer\u2019s disease dementia and behavioral and psychological symptoms of dementia: A retrospective cohort study","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/risk-factors-of-dementia-in-a-cohort-of-individuals-with-mild-39895250","doi":"10.1111/ene.16591","journal":"European Journal of Neurology","n_participants":356,"pmid":"39895250","source_url":"https://pubmed.ncbi.nlm.nih.gov/39895250/","study_design":null,"title":"Risk factors of dementia in a cohort of individuals with mild cognitive impairment in the Italian Interceptor project","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/predicting-dementia-in-people-with-parkinsons-disease-40360514","doi":"10.1038/s41531-025-00983-4","journal":"npj Parkinson s Disease","n_participants":null,"pmid":"40360514","source_url":"https://pubmed.ncbi.nlm.nih.gov/40360514/","study_design":null,"title":"Predicting dementia in people with Parkinson\u2019s disease","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/iron-species-in-cerebrospinal-fluid-and-dementia-risk-in-subjects-40609908","doi":"10.1016/j.neuro.2025.06.006","journal":"NeuroToxicology","n_participants":56,"pmid":"40609908","source_url":"https://pubmed.ncbi.nlm.nih.gov/40609908/","study_design":null,"title":"Iron species in cerebrospinal fluid and dementia risk in subjects with mild cognitive impairment: A cohort study","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/research-progress-in-predicting-the-conversion-from-mild-cognitive-40529431","doi":"10.3389/fneur.2025.1596632","journal":"Frontiers in Neurology","n_participants":null,"pmid":"40529431","source_url":"https://pubmed.ncbi.nlm.nih.gov/40529431/","study_design":null,"title":"Research progress in predicting the conversion from mild cognitive impairment to Alzheimer\u2019s disease via multimodal MRI and artificial intelligence","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/investigating-the-utility-of-explainable-artificial-intelligence-for-41626721","doi":"10.1002/hbm.70456","journal":"Human Brain Mapping","n_participants":null,"pmid":"41626721","source_url":"https://pubmed.ncbi.nlm.nih.gov/41626721/","study_design":null,"title":"Investigating the Utility of Explainable Artificial Intelligence for Neuroimaging\u2010Based Dementia Diagnosis and Prognosis","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/electroencephalogram-and-event-related-potential-in-mild-cognitive-20a9890e","doi":"10.1109/jsas.2025.3552546","journal":"IEEE Journal of Selected Areas in Sensors","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1109/jsas.2025.3552546","study_design":null,"title":"Electroencephalogram and Event-Related Potential in Mild Cognitive Impairment: Recent Developments in Signal Processing, Machine Learning, and Deep Learning","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/explainable-machine-learning-models-for-identifying-mild-cognitive-39838390","doi":"10.1186/s12912-025-02723-8","journal":"BMC Nursing","n_participants":612,"pmid":"39838390","source_url":"https://pubmed.ncbi.nlm.nih.gov/39838390/","study_design":"longitudinal study","title":"Explainable machine learning models for identifying mild cognitive impairment in older patients with chronic pain","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/machine-learning-based-strategy-identifies-a-robust-protein-biomarker-40616179","doi":"10.1186/s13195-025-01789-5","journal":"Alzheimer s Research & Therapy","n_participants":null,"pmid":"40616179","source_url":"https://pubmed.ncbi.nlm.nih.gov/40616179/","study_design":null,"title":"Machine-learning based strategy identifies a robust protein biomarker panel for Alzheimer\u2019s disease in cerebrospinal fluid","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/predicting-the-progression-of-mci-and-alzheimers-disease-on-40285975","doi":"10.1007/s11357-025-01626-5","journal":"GeroScience","n_participants":568,"pmid":"40285975","source_url":"https://pubmed.ncbi.nlm.nih.gov/40285975/","study_design":"cross-sectional","title":"Predicting the progression of MCI and Alzheimer\u2019s disease on structural brain integrity and other features with machine learning","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/developing-an-explainable-machine-learning-and-fog-computing-based-40670451","doi":"10.1038/s41598-025-06310-4","journal":"Scientific Reports","n_participants":450,"pmid":"40670451","source_url":"https://pubmed.ncbi.nlm.nih.gov/40670451/","study_design":null,"title":"Developing an explainable machine learning and fog computing-based visual rating scale for the prediction of dementia progression","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/handwriting-in-mild-cognitive-impairment-reliability-assessment-and-40986851","doi":"10.2196/73074","journal":"JMIR Aging","n_participants":57,"pmid":"40986851","source_url":"https://pubmed.ncbi.nlm.nih.gov/40986851/","study_design":null,"title":"Handwriting in Mild Cognitive Impairment: Reliability Assessment and Machine Learning\u2013Based Screening","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/299-sensors-in-home-for-elder-wellbeing-sinew-digital-phenotyping-and-f66c6bec","doi":"10.1093/ijnp/pyaf052.136","journal":"The International Journal of Neuropsychopharmacology","n_participants":87,"pmid":null,"source_url":"https://doi.org/10.1093/ijnp/pyaf052.136","study_design":"longitudinal study","title":"299. SENSORS IN-HOME FOR ELDER WELLBEING (SINEW): DIGITAL PHENOTYPING AND ARTIFICIAL INTELLIGENCE FOR EARLY DETECTION OF DEMENTIA","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/machine-learning-approaches-to-racial-ethnic-differences-in-social-40986403","doi":"10.1093/geronb/gbaf179","journal":"The Journals of Gerontology Series B","n_participants":83180,"pmid":"40986403","source_url":"https://pubmed.ncbi.nlm.nih.gov/40986403/","study_design":null,"title":"Machine learning approaches to racial/ethnic differences in social determinants of mild cognitive impairment and its progression to dementia in the All of Us Research Program","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/resource-stratified-machine-learning-framework-for-cognitive-status-41794745","doi":"10.1186/s13195-026-02006-7","journal":"Alzheimer s Research & Therapy","n_participants":31081,"pmid":"41794745","source_url":"https://pubmed.ncbi.nlm.nih.gov/41794745/","study_design":null,"title":"Resource-stratified machine learning framework for cognitive status classification and mild cognitive impairment to dementia progression prediction","title_match":true,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cognitive-dysfunction-and-dementia-in-type-2-diabetes-mellitus-40810170","doi":"10.1021/acsptsci.5c00086","journal":"ACS Pharmacology & Translational Science","n_participants":null,"pmid":"40810170","source_url":"https://pubmed.ncbi.nlm.nih.gov/40810170/","study_design":null,"title":"Cognitive Dysfunction and Dementia in Type 2 Diabetes Mellitus: Insights into Mechanisms, Models, and Therapeutics","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/bace1-as-an-early-biomarker-and-its-relevance-to-risk-factors-for-40706761","doi":"10.1016/j.brainresbull.2025.111475","journal":"Brain Research Bulletin","n_participants":null,"pmid":"40706761","source_url":"https://pubmed.ncbi.nlm.nih.gov/40706761/","study_design":null,"title":"BACE1 as an early biomarker and its relevance to risk factors for Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/changes-in-sleep-dimensions-cognitive-transitions-and-incident-40795941","doi":"10.1093/sleep/zsaf233","journal":"SLEEP","n_participants":720,"pmid":"40795941","source_url":"https://pubmed.ncbi.nlm.nih.gov/40795941/","study_design":"longitudinal study","title":"Changes in sleep dimensions, cognitive transitions, and incident dementia: a two-cohort longitudinal study","title_match":false,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/life-stress-and-dementia-risk-in-adults-with-down-syndrome-0b6c1de8","doi":"10.1093/geroni/igaf122.3619","journal":"Innovation in Aging","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1093/geroni/igaf122.3619","study_design":null,"title":"Life Stress and Dementia Risk in Adults with Down Syndrome","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/factors-associated-with-atypical-cognitive-trajectories-in-older-41449092","doi":"10.1002/alz70857_105703","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41449092","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740825/","study_design":"longitudinal study","title":"Factors Associated with Atypical Cognitive Trajectories in Older Adults with Down Syndrome","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/longitudinal-fdg-pet-metabolic-change-along-the-lewy-body-continuum-39804619","doi":"10.1001/jamaneurol.2024.4643","journal":"JAMA Neurology","n_participants":72,"pmid":"39804619","source_url":"https://pubmed.ncbi.nlm.nih.gov/39804619/","study_design":"case-control study","title":"Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/atrophy-patterns-of-deep-gray-matter-nuclei-in-alzheimer-s-disease-41160467","doi":"10.1177/13872877251390386","journal":"Journal of Alzheimer s Disease","n_participants":380,"pmid":"41160467","source_url":"https://pubmed.ncbi.nlm.nih.gov/41160467/","study_design":"longitudinal study","title":"Atrophy patterns of deep gray matter nuclei in Alzheimer's disease and frontotemporal dementia","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-role-of-quantitative-eeg-biomarkers-in-alzheimers-disease-and-40336944","doi":"10.3389/fnagi.2025.1522552","journal":"Frontiers in Aging Neuroscience","n_participants":null,"pmid":"40336944","source_url":"https://pubmed.ncbi.nlm.nih.gov/40336944/","study_design":null,"title":"The role of quantitative EEG biomarkers in Alzheimer\u2019s disease and mild cognitive impairment: applications and insights","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/poor-glymphatic-function-is-associated-with-mild-cognitive-impairment-40221240","doi":"10.1016/j.tjpad.2025.100156","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":519,"pmid":"40221240","source_url":"https://pubmed.ncbi.nlm.nih.gov/40221240/","study_design":null,"title":"Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer's disease: A DTI-ALPS study","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-role-of-gut-microbiota-derived-trimethylamine-n-oxide-in-the-39941141","doi":"10.3390/ijms26031373","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"39941141","source_url":"https://pubmed.ncbi.nlm.nih.gov/39941141/","study_design":null,"title":"The Role of Gut Microbiota-Derived Trimethylamine N-Oxide in the Pathogenesis and Treatment of Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/event-related-potential-markers-of-subjective-cognitive-decline-and-40023055","doi":"10.1016/j.nicl.2025.103760","journal":"NeuroImage Clinical","n_participants":178,"pmid":"40023055","source_url":"https://pubmed.ncbi.nlm.nih.gov/40023055/","study_design":null,"title":"Event-related potential markers of subjective cognitive decline and mild cognitive impairment during a sustained visuo-attentive task","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/transcriptomic-predictors-of-rapid-progression-from-mild-cognitive-39754267","doi":"10.1186/s13195-024-01651-0","journal":"Alzheimer s Research & Therapy","n_participants":28,"pmid":"39754267","source_url":"https://pubmed.ncbi.nlm.nih.gov/39754267/","study_design":"longitudinal study","title":"Transcriptomic predictors of rapid progression from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/federated-learning-with-multicohort-realworld-data-for-predicting-the-40219846","doi":"10.1002/alz.70128","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40219846","source_url":"https://pubmed.ncbi.nlm.nih.gov/40219846/","study_design":null,"title":"Federated learning with multi\u2010cohort real\u2010world data for predicting the progression from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/eye-tracking-based-detection-of-mild-cognitive-impairment-a-review-1b1a6cf1","doi":"10.1016/j.inffus.2025.103202","journal":"Information Fusion","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.inffus.2025.103202","study_design":null,"title":"Eye tracking based detection of mild cognitive impairment: A review","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/caregiver-burden-in-mild-cognitive-impairment-due-to-alzheimer-s-40202055","doi":"10.1111/psyg.70033","journal":"Psychogeriatrics","n_participants":null,"pmid":"40202055","source_url":"https://pubmed.ncbi.nlm.nih.gov/40202055/","study_design":null,"title":"Caregiver burden in mild cognitive impairment due to Alzheimer's disease\u2014a longitudinal study","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/clinical-and-neuropsychological-features-associated-with-progression-41383817","doi":"10.3389/fnagi.2025.1680762","journal":"Frontiers in Aging Neuroscience","n_participants":450,"pmid":"41383817","source_url":"https://pubmed.ncbi.nlm.nih.gov/41383817/","study_design":null,"title":"Clinical and neuropsychological features associated with progression in subjective cognitive decline","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/enhanced-detection-of-mild-cognitive-impairment-in-alzheimers-disease-39849395","doi":"10.1186/s12877-025-05683-5","journal":"BMC Geriatrics","n_participants":null,"pmid":"39849395","source_url":"https://pubmed.ncbi.nlm.nih.gov/39849395/","study_design":null,"title":"Enhanced detection of mild cognitive impairment in Alzheimer\u2019s disease: a hybrid model integrating dual biomarkers and advanced machine learning","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/deep-learning-based-framework-for-predicting-mild-cognitive-a879517e","doi":"10.1109/access.2025.3562432","journal":"IEEE Access","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1109/access.2025.3562432","study_design":"longitudinal study","title":"Deep Learning-Based Framework for Predicting Mild Cognitive Impairment Progression in Neurology Using Longitudinal MRI","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/sexspecific-association-of-depressive-symptom-trajectories-with-40754890","doi":"10.1002/alz.70548","journal":"Alzheimer s & Dementia","n_participants":811,"pmid":"40754890","source_url":"https://pubmed.ncbi.nlm.nih.gov/40754890/","study_design":"longitudinal study","title":"Sex\u2010specific association of depressive symptom trajectories with cognitive decline and clinical progression in mild cognitive impairment","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/multimodal-magnetic-resonance-imaging-analysis-of-early-mild-40033775","doi":"10.1177/13872877251321187","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40033775","source_url":"https://pubmed.ncbi.nlm.nih.gov/40033775/","study_design":null,"title":"Multimodal magnetic resonance imaging analysis of early mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/detection-of-alzheimer-and-mild-cognitive-impairment-patients-by-40275232","doi":"10.1186/s12938-025-01369-6","journal":"BioMedical Engineering OnLine","n_participants":null,"pmid":"40275232","source_url":"https://pubmed.ncbi.nlm.nih.gov/40275232/","study_design":null,"title":"Detection of Alzheimer and mild cognitive impairment patients by Poincare and Entropy methods based on electroencephalography signals","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/revealing-heterogeneity-in-mild-cognitive-impairment-based-on-40375286","doi":"10.1186/s13195-025-01752-4","journal":"Alzheimer s Research & Therapy","n_participants":null,"pmid":"40375286","source_url":"https://pubmed.ncbi.nlm.nih.gov/40375286/","study_design":null,"title":"Revealing heterogeneity in mild cognitive impairment based on individualized structural covariance network","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/a-multimodal-approach-for-early-identification-of-mild-cognitive-40232896","doi":"10.1109/tnsre.2025.3561043","journal":"IEEE Transactions on Neural Systems and Rehabilitation Engineering","n_participants":78,"pmid":"40232896","source_url":"https://pubmed.ncbi.nlm.nih.gov/40232896/","study_design":null,"title":"A Multimodal Approach for Early Identification of Mild Cognitive Impairment and Alzheimer\u2019s Disease With Fusion Network Using Eye Movements and Speech","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/exploring-the-neuromagnetic-signatures-of-cognitive-decline-from-mild-40153923","doi":"10.1016/j.ebiom.2025.105659","journal":"EBioMedicine","n_participants":117,"pmid":"40153923","source_url":"https://pubmed.ncbi.nlm.nih.gov/40153923/","study_design":null,"title":"Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/parallel-changes-in-cognition-neuropsychiatric-symptoms-and-amyloid-39936256","doi":"10.1002/alz.14568","journal":"Alzheimer s & Dementia","n_participants":1247,"pmid":"39936256","source_url":"https://pubmed.ncbi.nlm.nih.gov/39936256/","study_design":"longitudinal study","title":"Parallel changes in cognition, neuropsychiatric symptoms, and amyloid in cognitively unimpaired older adults and those with mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/allostatic-load-dynamics-alzheimer-s-disease-biomarkers-and-40606518","doi":"10.1002/dad2.70140","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":385,"pmid":"40606518","source_url":"https://pubmed.ncbi.nlm.nih.gov/40606518/","study_design":null,"title":"Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/impact-of-cardiometabolic-conditions-on-the-progression-from-mild-40951936","doi":"10.1002/alz.70692","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40951936","source_url":"https://pubmed.ncbi.nlm.nih.gov/40951936/","study_design":null,"title":"Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/polypharmacy-and-risk-of-dementia-progression-in-older-adults-with-41268047","doi":"10.1002/trc2.70179","journal":"Alzheimer s & Dementia Translational Research & Clinical Interventions","n_participants":null,"pmid":"41268047","source_url":"https://pubmed.ncbi.nlm.nih.gov/41268047/","study_design":"cohort study","title":"Polypharmacy and risk of dementia progression in older adults with mild cognitive impairment: A longitudinal cohort study","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/potentially-inappropriate-medications-related-to-two-year-progression-41553533","doi":"10.1007/s00228-025-03977-6","journal":"European Journal of Clinical Pharmacology","n_participants":397,"pmid":"41553533","source_url":"https://pubmed.ncbi.nlm.nih.gov/41553533/","study_design":null,"title":"Potentially inappropriate medications related to two-year progression of mild cognitive impairment and dementia","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/transcranial-direct-current-stimulation-for-global-cognition-in-mild-39958266","doi":"10.4068/cmj.2025.61.1.1","journal":"Chonnam Medical Journal","n_participants":null,"pmid":"39958266","source_url":"https://pubmed.ncbi.nlm.nih.gov/39958266/","study_design":"longitudinal study","title":"Transcranial Direct Current Stimulation for Global Cognition in Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-analysis-of-the-gut-microbiome-during-liver-disease-progression-41035890","doi":"10.3389/fmicb.2025.1670512","journal":"Frontiers in Microbiology","n_participants":null,"pmid":"41035890","source_url":"https://pubmed.ncbi.nlm.nih.gov/41035890/","study_design":null,"title":"The analysis of the gut microbiome during liver disease progression led to the identification of biomarkers for related mild cognitive impairment","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/research-progress-of-multimodal-biomarkers-in-the-early-diagnosis-of-40948659","doi":"10.3389/fneur.2025.1652378","journal":"Frontiers in Neurology","n_participants":null,"pmid":"40948659","source_url":"https://pubmed.ncbi.nlm.nih.gov/40948659/","study_design":null,"title":"Research progress of multimodal biomarkers in the early diagnosis of mild cognitive impairment in Parkinson\u2019s disease","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/subclinical-left-ventricular-dysfunction-assessed-by-global-40097616","doi":"10.1038/s41440-025-02182-3","journal":"Hypertension Research","n_participants":180,"pmid":"40097616","source_url":"https://pubmed.ncbi.nlm.nih.gov/40097616/","study_design":"longitudinal study","title":"Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-and-sarcopenia-effects-of-resistance-41303517","doi":"10.3390/ijms262211036","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"41303517","source_url":"https://pubmed.ncbi.nlm.nih.gov/41303517/","study_design":"narrative review","title":"Mild Cognitive Impairment and Sarcopenia: Effects of Resistance Exercise Training on Neuroinflammation, Cognitive Performance, and Structural Brain Changes","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/multiplex-cerebrospinal-fluid-proteomics-identifies-biomarkers-41553038","doi":"10.1096/fj.202504014r","journal":"The FASEB Journal","n_participants":509,"pmid":"41553038","source_url":"https://pubmed.ncbi.nlm.nih.gov/41553038/","study_design":"longitudinal study","title":"Multiplex Cerebrospinal Fluid Proteomics Identifies Biomarkers Predicting Neuropsychiatric Symptom Progression in Mild Cognitive Impairment and Alzheimer's Disease","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-radiomics-model-predicts-progression-from-mild-cognitive-impairment-41083541","doi":"10.1038/s41598-025-19586-3","journal":"Scientific Reports","n_participants":240,"pmid":"41083541","source_url":"https://pubmed.ncbi.nlm.nih.gov/41083541/","study_design":null,"title":"A radiomics model predicts progression from mild cognitive impairment to alzheimer\u2019s disease using structural MRI","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/electroencephalographybased-signatures-of-cognitive-resilience-in-41425085","doi":"10.1002/trc2.70194","journal":"Alzheimer s & Dementia Translational Research & Clinical Interventions","n_participants":null,"pmid":"41425085","source_url":"https://pubmed.ncbi.nlm.nih.gov/41425085/","study_design":null,"title":"Electroencephalography\u2010based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high\u2010risk for progression to dementia","title_match":true,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/biomarkers-for-alzheimer-s-disease-and-mild-cognitive-impairment-41636372","doi":"10.1177/13872877251413700","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"41636372","source_url":"https://pubmed.ncbi.nlm.nih.gov/41636372/","study_design":"systematic review","title":"Biomarkers for Alzheimer's disease and mild cognitive impairment: Recent advances in task-based EEG","title_match":false,"year":2026},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/multi-omics-profiling-reveals-two-distinct-trajectories-in-the-40770955","doi":"10.1177/13872877251365210","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40770955","source_url":"https://pubmed.ncbi.nlm.nih.gov/40770955/","study_design":null,"title":"Multi-omics profiling reveals two distinct trajectories in the progression from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/gender-differences-in-cognitive-reserve-an-impact-on-progression-in-40881583","doi":"10.1002/dad2.70174","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":440,"pmid":"40881583","source_url":"https://pubmed.ncbi.nlm.nih.gov/40881583/","study_design":null,"title":"Gender differences in cognitive reserve: An impact on progression in subjective cognitive decline?","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/progression-of-clinical-diagnostic-features-and-cognitive-decline-in-40552972","doi":"10.1017/s0033291725100895","journal":"Psychological Medicine","n_participants":74,"pmid":"40552972","source_url":"https://pubmed.ncbi.nlm.nih.gov/40552972/","study_design":"cohort study","title":"Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/individualized-prediction-of-transition-from-subjective-cognitive-41478831","doi":"10.1016/j.tjpad.2025.100462","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":89,"pmid":"41478831","source_url":"https://pubmed.ncbi.nlm.nih.gov/41478831/","study_design":null,"title":"Individualized prediction of transition from subjective cognitive decline to mild cognitive impairment based on multimodal MRI: a 10-year follow-up study","title_match":false,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/comparison-of-deep-learning-and-traditional-machine-learning-models-40141072","doi":"10.3390/ijms26062428","journal":"International Journal of Molecular Sciences","n_participants":239,"pmid":"40141072","source_url":"https://pubmed.ncbi.nlm.nih.gov/40141072/","study_design":null,"title":"Comparison of Deep Learning and Traditional Machine Learning Models for Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers","title_match":false,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-in-mild-cognitive-impairment-and-early-41523330","doi":"10.3934/neuroscience.2025032","journal":"AIMS neuroscience","n_participants":null,"pmid":"41523330","source_url":"https://pubmed.ncbi.nlm.nih.gov/41523330/","study_design":"narrative review","title":"Neuropsychiatric symptoms in mild cognitive impairment and early Alzheimer's disease: Clinical pattern and diagnostic implications","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/gray-and-white-matter-pathology-progression-in-parkinson-s-disease-41519606","doi":"10.1002/alz70856_106745","journal":"Alzheimer s & Dementia","n_participants":47,"pmid":"41519606","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12790459/","study_design":"longitudinal study","title":"Gray and white matter pathology progression in Parkinson's disease patients that develop mild cognitive impairment","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/talking-during-walking-the-diagnostic-potential-of-turn-dynamics-in-40046785","doi":"10.3389/fnagi.2025.1533573","journal":"Frontiers in Aging Neuroscience","n_participants":75,"pmid":"40046785","source_url":"https://pubmed.ncbi.nlm.nih.gov/40046785/","study_design":null,"title":"Talking during walking: the diagnostic potential of turn dynamics in Alzheimer\u2019s disease, mild cognitive impairment and cognitive aging","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/barriers-to-self-management-engagement-among-community-dwelling-older-39850071","doi":"10.3389/fpsyt.2024.1446344","journal":"Frontiers in Psychiatry","n_participants":null,"pmid":"39850071","source_url":"https://pubmed.ncbi.nlm.nih.gov/39850071/","study_design":null,"title":"Barriers to self-management engagement among community-dwelling older adults with mild cognitive impairment: a qualitative study","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/effect-of-ssris-on-clinical-progression-in-amnestic-mild-cognitive-41292493","doi":"10.1002/alz.70946","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41292493","source_url":"https://pubmed.ncbi.nlm.nih.gov/41292493/","study_design":"longitudinal study","title":"Effect of SSRIs on clinical progression in amnestic mild cognitive impairment stratified by Alzheimer's disease pathology","title_match":true,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-disease-prognosis-in-mild-cognitive-impairment-40156325","doi":"10.1002/mds.30181","journal":"Movement Disorders","n_participants":131,"pmid":"40156325","source_url":"https://pubmed.ncbi.nlm.nih.gov/40156325/","study_design":"longitudinal study","title":"Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/areactive-t-cell-polyfunctionality-response-as-a-new-biomarker-for-39758054","doi":"10.1002/dad2.70042","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":null,"pmid":"39758054","source_url":"https://pubmed.ncbi.nlm.nih.gov/39758054/","study_design":null,"title":"A\u03b2\u2010reactive T cell polyfunctionality response as a new biomarker for mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gait-analysis-in-older-adults-with-mild-cognitive-impairment-a-40612530","doi":"10.3389/fragi.2025.1592464","journal":"Frontiers in Aging","n_participants":1223,"pmid":"40612530","source_url":"https://pubmed.ncbi.nlm.nih.gov/40612530/","study_design":null,"title":"Gait analysis in older adults with mild cognitive impairment: a bibliometric analysis of global trends, hotspots, and emerging frontiers","title_match":false,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-due-to-cerebrovascular-disease-and-72d29644","doi":"10.14412/2074-2711-2025-3-77-83","journal":"Neurology neuropsychiatry Psychosomatics","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.14412/2074-2711-2025-3-77-83","study_design":null,"title":"Mild cognitive impairment due to cerebrovascular disease and Alzheimer\u2019s","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/probiotic-supplementation-improves-the-clinical-measures-of-cognition-40918855","doi":"10.7759/cureus.89302","journal":"Cureus","n_participants":null,"pmid":"40918855","source_url":"https://pubmed.ncbi.nlm.nih.gov/40918855/","study_design":null,"title":"Probiotic Supplementation Improves the Clinical Measures of Cognition in Patients With Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-impact-of-cholinesterase-inhibitors-on-cognitive-trajectories-in-41568736","doi":"10.1002/alz.70193","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41568736","source_url":"https://pubmed.ncbi.nlm.nih.gov/41568736/","study_design":"longitudinal study","title":"The impact of cholinesterase inhibitors on cognitive trajectories in mild cognitive impairment patients based on amyloid beta status","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/conventional-and-neuropsychological-criteria-for-mild-cognitive-40473666","doi":"10.1038/s41598-025-04275-y","journal":"Scientific Reports","n_participants":null,"pmid":"40473666","source_url":"https://pubmed.ncbi.nlm.nih.gov/40473666/","study_design":null,"title":"Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/distinguishing-early-from-late-mild-cognitive-impairment-using-39846567","doi":"10.3390/neurosci6010008","journal":"NeuroSci","n_participants":476,"pmid":"39846567","source_url":"https://pubmed.ncbi.nlm.nih.gov/39846567/","study_design":null,"title":"Distinguishing Early from Late Mild Cognitive Impairment Using Magnetic Resonance Free-Water Diffusion Tensor Imaging","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/taurelated-reduction-of-glucose-metabolism-in-mild-cognitive-39989007","doi":"10.1002/alz.14625","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"39989007","source_url":"https://pubmed.ncbi.nlm.nih.gov/39989007/","study_design":null,"title":"Tau\u2010related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE \u03b54 genotype and is influenced by A\u03b2","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/prediction-of-mild-cognitive-impairment-progression-using-time-41040687","doi":"10.1126/sciadv.aee2305","journal":"Science Advances","n_participants":102,"pmid":"41040687","source_url":"https://pubmed.ncbi.nlm.nih.gov/41040687/","study_design":null,"title":"Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairmenttoalzheimer-s-dementia-progression-risk-the-41949058","doi":"10.1002/alz.71204","journal":"Alzheimer s & Dementia","n_participants":398,"pmid":"41949058","source_url":"https://pubmed.ncbi.nlm.nih.gov/41949058/","study_design":null,"title":"Mild cognitive impairment\u2010to\u2010Alzheimer's dementia progression risk: the contribution of the Interceptor project","title_match":true,"year":2026},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/advancing-early-diagnosis-predicting-mild-cognitive-impairment-dec3cad3","doi":"10.1109/access.2025.3588801","journal":"IEEE Access","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1109/access.2025.3588801","study_design":null,"title":"Advancing Early Diagnosis: Predicting Mild Cognitive Impairment Progression in Normal Individuals Using Deep Learning on MRI Features","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/changes-in-the-parietal-lobe-subregion-volume-at-various-stages-of-39862009","doi":"10.31083/jin25991","journal":"Journal of Integrative Neuroscience","n_participants":662,"pmid":"39862009","source_url":"https://pubmed.ncbi.nlm.nih.gov/39862009/","study_design":null,"title":"Changes in the Parietal Lobe Subregion Volume at Various Stages of Alzheimer\u2019s Disease and the Role in Cognitively Normal and Mild Cognitive Impairment Conversion","title_match":true,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/altered-default-mode-network-connectivity-in-mild-cognitive-40231538","doi":"10.2174/0115672050352061250328055829","journal":"Current Alzheimer Research","n_participants":null,"pmid":"40231538","source_url":"https://pubmed.ncbi.nlm.nih.gov/40231538/","study_design":null,"title":"Altered Default Mode Network Connectivity in Mild Cognitive Impairment: Insights from Resting-State fMRI Studies","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-role-of-verbal-episodic-memory-in-progression-to-mild-cognitive-42000212","doi":"10.1016/j.inpsyc.2026.100212","journal":"International Psychogeriatrics","n_participants":315,"pmid":"42000212","source_url":"https://pubmed.ncbi.nlm.nih.gov/42000212/","study_design":null,"title":"The role of verbal episodic memory in progression to mild cognitive impairment: The influence of serial position effects","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-a-multivariate-gut-microbiome-model-for-40429881","doi":"10.3390/ijms26104735","journal":"International Journal of Molecular Sciences","n_participants":14,"pmid":"40429881","source_url":"https://pubmed.ncbi.nlm.nih.gov/40429881/","study_design":"cross-sectional","title":"Prognostic Value of a Multivariate Gut Microbiome Model for Progression from Normal Cognition to Mild Cognitive Impairment Within 4 Years","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau217a-pivotal-plasma-biomarker-for-predicting-42117479","doi":"10.1080/13803395.2026.2671206","journal":"Journal of Clinical and Experimental Neuropsychology","n_participants":47,"pmid":"42117479","source_url":"https://pubmed.ncbi.nlm.nih.gov/42117479/","study_design":"longitudinal study","title":"Plasma Phosphorylated Tau217\u2013A Pivotal Plasma Biomarker for Predicting the Progression of Mild Cognitive Impairment to Alzheimer\u2019s Disease: A Reanalysis of ADNI Data","title_match":true,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/prediction-of-mild-cognitive-impairment-using-blood-multi-omics-data-40491569","doi":"10.3389/fgene.2025.1552063","journal":"Frontiers in Genetics","n_participants":null,"pmid":"40491569","source_url":"https://pubmed.ncbi.nlm.nih.gov/40491569/","study_design":null,"title":"Prediction of mild cognitive impairment using blood multi-omics data","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/profiling-characteristics-of-plasma-exosomal-mirnas-across-cognitive-40630682","doi":"10.1039/d5ra02993g","journal":"RSC Advances","n_participants":null,"pmid":"40630682","source_url":"https://pubmed.ncbi.nlm.nih.gov/40630682/","study_design":null,"title":"Profiling characteristics of plasma exosomal miRNAs across cognitive stages: from normalcy to mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/clinical-parameters-predicted-the-progression-to-dementia-in-oldest-40803947","doi":"10.1016/j.inpsyc.2025.100129","journal":"International Psychogeriatrics","n_participants":null,"pmid":"40803947","source_url":"https://pubmed.ncbi.nlm.nih.gov/40803947/","study_design":"case-control study","title":"Clinical parameters predicted the progression to dementia in oldest old patients with mild cognitive impairment (MCI)","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/disagreement-between-self-and-informant-reported-memory-complaints-40857141","doi":"10.1080/13607863.2025.2552425","journal":"Aging & Mental Health","n_participants":null,"pmid":"40857141","source_url":"https://pubmed.ncbi.nlm.nih.gov/40857141/","study_design":"longitudinal study","title":"Disagreement between self- and informant-reported memory complaints and progression of mild cognitive impairment to dementia","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/integrated-amyloid-neurodegeneration-and-vascular-biomarkers-estimate-42159446","doi":"10.1177/13872877261445623","journal":"Journal of Alzheimer s Disease","n_participants":58,"pmid":"42159446","source_url":"https://pubmed.ncbi.nlm.nih.gov/42159446/","study_design":"longitudinal study","title":"Integrated amyloid, neurodegeneration, and vascular biomarkers estimate the risk of dementia progression in mild cognitive impairment","title_match":true,"year":2026},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/a-deep-hybrid-cnn-bilstm-bigru-architecture-with-explainability-for-42108320","doi":"10.1186/s40708-026-00302-4","journal":"Brain Informatics","n_participants":null,"pmid":"42108320","source_url":"https://pubmed.ncbi.nlm.nih.gov/42108320/","study_design":null,"title":"A deep hybrid CNN-BiLSTM-BiGRU architecture with explainability for mild cognitive impairment detection using EEG","title_match":false,"year":2026},{"alzhub_score":29,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-a-pre-dementia-syndrome-194e158e","doi":"10.48087/bjmsra.2025.12324","journal":"Batna Journal of Medical Sciences (BJMS)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.48087/bjmsra.2025.12324","study_design":null,"title":"Mild Cognitive Impairment: A Pre-Dementia Syndrome","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/comprehensive-anatomical-staging-predicts-clinical-progression-in-40564976","doi":"10.3390/ijms26125514","journal":"International Journal of Molecular Sciences","n_participants":504,"pmid":"40564976","source_url":"https://pubmed.ncbi.nlm.nih.gov/40564976/","study_design":null,"title":"Comprehensive Anatomical Staging Predicts Clinical Progression in Mild Cognitive Impairment: A Data-Driven Approach","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/longitudinal-analysis-of-amyloid-pet-and-brain-mri-for-predicting-40137577","doi":"10.3390/tomography11030037","journal":"Tomography","n_participants":180,"pmid":"40137577","source_url":"https://pubmed.ncbi.nlm.nih.gov/40137577/","study_design":"longitudinal study","title":"Longitudinal Analysis of Amyloid PET and Brain MRI for Predicting Conversion from Mild Cognitive Impairment to Alzheimer\u2019s Disease: Findings from the ADNI Cohort","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/association-of-small-vessel-disease-progression-with-longitudinal-39791370","doi":"10.1177/13872877241305800","journal":"Journal of Alzheimer s Disease","n_participants":432,"pmid":"39791370","source_url":"https://pubmed.ncbi.nlm.nih.gov/39791370/","study_design":"longitudinal study","title":"Association of small vessel disease progression with longitudinal cognitive decline across mild cognitive impairment","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/linking-oxysterols-and-different-stages-of-mild-cognitive-impairment-40361183","doi":"10.1186/s13195-025-01743-5","journal":"Alzheimer s Research & Therapy","n_participants":35,"pmid":"40361183","source_url":"https://pubmed.ncbi.nlm.nih.gov/40361183/","study_design":null,"title":"Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/multimodal-dti-alps-and-hippocampal-microstructural-signatures-unveil-40791246","doi":"10.3389/fnagi.2025.1609793","journal":"Frontiers in Aging Neuroscience","n_participants":null,"pmid":"40791246","source_url":"https://pubmed.ncbi.nlm.nih.gov/40791246/","study_design":"cross-sectional","title":"Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer\u2019s disease progression","title_match":false,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-and-progression-to-pathologically-confirmed-40279515","doi":"10.1093/brain/awaf156","journal":"Brain","n_participants":1016,"pmid":"40279515","source_url":"https://pubmed.ncbi.nlm.nih.gov/40279515/","study_design":null,"title":"Neuropsychiatric symptoms and progression to pathologically confirmed Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/effect-of-aspirin-use-on-conversion-risk-from-mild-cognitive-40842647","doi":"10.3389/fnagi.2025.1603892","journal":"Frontiers in Aging Neuroscience","n_participants":508107,"pmid":"40842647","source_url":"https://pubmed.ncbi.nlm.nih.gov/40842647/","study_design":"cohort study","title":"Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer\u2019s disease","title_match":true,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/disease-progression-from-mild-cognitive-impairment-to-dementia-for-40655923","doi":"10.1177/25424823251359541","journal":"Journal of Alzheimer s Disease Reports","n_participants":null,"pmid":"40655923","source_url":"https://pubmed.ncbi.nlm.nih.gov/40655923/","study_design":null,"title":"Disease progression from mild cognitive impairment to dementia for patients with Alzheimer's disease or Lewy body pathology","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/uncovering-stagespecific-neural-and-molecular-progression-in-40386988","doi":"10.1002/alz.70182","journal":"Alzheimer s & Dementia","n_participants":277,"pmid":"40386988","source_url":"https://pubmed.ncbi.nlm.nih.gov/40386988/","study_design":null,"title":"Uncovering stage\u2010specific neural and molecular progression in Alzheimer's disease: Implications for early screening","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/early-dysregulation-of-rna-splicing-and-translation-processes-are-key-40806433","doi":"10.3390/ijms26157303","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"40806433","source_url":"https://pubmed.ncbi.nlm.nih.gov/40806433/","study_design":null,"title":"Early Dysregulation of RNA Splicing and Translation Processes Are Key Markers from Mild Cognitive Impairment to Alzheimer\u2019s Disease: An In Silico Transcriptomic Analysis","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lipidomic-signatures-reveal-biomarkers-of-mild-cognitive-impairment-41692848","doi":"10.1038/s41398-026-03893-y","journal":"Translational Psychiatry","n_participants":null,"pmid":"41692848","source_url":"https://pubmed.ncbi.nlm.nih.gov/41692848/","study_design":"longitudinal study","title":"Lipidomic signatures reveal biomarkers of mild cognitive impairment","title_match":false,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/dynamic-cerebral-autoregulation-in-people-with-mild-cognitive-40458006","doi":"10.1177/0271678x251345361","journal":"Journal of Cerebral Blood Flow & Metabolism","n_participants":30,"pmid":"40458006","source_url":"https://pubmed.ncbi.nlm.nih.gov/40458006/","study_design":null,"title":"Dynamic cerebral autoregulation in people with mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-alzheimers-disease-and-progression-across-41276530","doi":"10.1038/s41467-025-66728-2","journal":"Nature Communications","n_participants":null,"pmid":"41276530","source_url":"https://pubmed.ncbi.nlm.nih.gov/41276530/","study_design":null,"title":"Blood biomarkers of Alzheimer\u2019s disease and progression across different stages of cognitive decline in the community","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/diabetic-retinopathy-as-the-primary-predictor-of-mild-cognitive-41004471","doi":"10.1371/journal.pone.0332442","journal":"PLoS ONE","n_participants":100,"pmid":"41004471","source_url":"https://pubmed.ncbi.nlm.nih.gov/41004471/","study_design":"prospective cohort","title":"Diabetic retinopathy as the primary predictor of mild cognitive impairment in type 2 diabetes: Insights from machine learning models","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/beyond-the-clock-exploring-multimodal-behavior-markers-of-mild-2981775f","doi":"10.1145/3770684","journal":"Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1145/3770684","study_design":null,"title":"Beyond the Clock: Exploring Multimodal Behavior Markers of Mild Cognitive Impairment in Older Adults during Clock Drawing Test","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-longitudinal-analysis-of-t1-weighted-mri-features-associated-with-42115951","doi":"10.1186/s12880-026-02404-1","journal":"BMC Medical Imaging","n_participants":947,"pmid":"42115951","source_url":"https://pubmed.ncbi.nlm.nih.gov/42115951/","study_design":"longitudinal study","title":"A longitudinal analysis of T1-weighted MRI features associated with progression from mild cognitive impairment to Alzheimer\u2019s disease","title_match":true,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/transcriptome-informed-metabolic-modeling-reveals-astrocyte-specific-42311824","doi":"10.3389/fbinf.2026.1816121","journal":"Frontiers in Bioinformatics","n_participants":null,"pmid":"42311824","source_url":"https://pubmed.ncbi.nlm.nih.gov/42311824/","study_design":null,"title":"Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer\u2019s disease progression","title_match":true,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/data-driven-clinical-decision-support-tool-for-diagnosing-mild-41526401","doi":"10.1038/s41531-025-01222-6","journal":"npj Parkinson s Disease","n_participants":115,"pmid":"41526401","source_url":"https://pubmed.ncbi.nlm.nih.gov/41526401/","study_design":"longitudinal study","title":"Data-driven clinical decision support tool for diagnosing mild cognitive impairment in Parkinson\u2019s disease","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-a42-a40-determined-by-mass-spectrometry-is-associated-with-41513583","doi":"10.1016/j.tjpad.2025.100465","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":200,"pmid":"41513583","source_url":"https://pubmed.ncbi.nlm.nih.gov/41513583/","study_design":"longitudinal study","title":"Plasma A\u03b242/A\u03b240 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer\u2019s disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/timedependent-biomarker-accuracy-in-forecasting-mild-cognitive-41433380","doi":"10.1002/alz70862_110285","journal":"Alzheimer s & Dementia","n_participants":102,"pmid":"41433380","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725005/","study_design":"longitudinal study","title":"Time\u2010dependent biomarker accuracy in forecasting mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-among-older-adults-in-outpatient-clinics-40669732","doi":"10.1016/j.exger.2025.112834","journal":"Experimental Gerontology","n_participants":null,"pmid":"40669732","source_url":"https://pubmed.ncbi.nlm.nih.gov/40669732/","study_design":null,"title":"Mild cognitive impairment among older adults in outpatient clinics: Awareness and knowledge needs survey","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-pilot-randomized-controlled-double-blind-trial-of-intermittent-40170189","doi":"10.1186/s40814-025-01625-5","journal":"Pilot and Feasibility Studies","n_participants":20,"pmid":"40170189","source_url":"https://pubmed.ncbi.nlm.nih.gov/40170189/","study_design":null,"title":"A pilot randomized controlled double-blind trial of intermittent theta burst stimulation (iTBS) repetitive transcranial magnetic stimulation (rTMS) to improve memory in mild cognitive impairment (MCI): a study protocol","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/neuroprotective-antioxidant-and-anti-inflammatory-effect-of-greek-40427737","doi":"10.3390/biology14050548","journal":"Biology","n_participants":null,"pmid":"40427737","source_url":"https://pubmed.ncbi.nlm.nih.gov/40427737/","study_design":null,"title":"Neuroprotective, Antioxidant and Anti-Inflammatory Effect of Greek Pomegranate Seed Oil on N2a Neuroblastoma Cells and Mild Cognitive Impairment Patients","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/rationale-and-design-of-a-multidomain-lifestyle-program-for-mild-41605825","doi":"10.1002/alz.71068","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41605825","source_url":"https://pubmed.ncbi.nlm.nih.gov/41605825/","study_design":null,"title":"Rationale and design of a multidomain lifestyle program for mild cognitive impairment","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/characterizing-bidirectional-transitions-in-mild-cognitive-impairment-40387264","doi":"10.1002/alz.70263","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40387264","source_url":"https://pubmed.ncbi.nlm.nih.gov/40387264/","study_design":"retrospective cohort","title":"Characterizing bidirectional transitions in mild cognitive impairment and post\u2010reversion based on longitudinal neuroimaging and cognitive assessments","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/cardiometabolic-disorders-and-mild-cognitive-impairment-in-white-and-40926187","doi":"10.1002/alz.70642","journal":"Alzheimer s & Dementia","n_participants":8737,"pmid":"40926187","source_url":"https://pubmed.ncbi.nlm.nih.gov/40926187/","study_design":null,"title":"Cardiometabolic disorders and mild cognitive impairment in White and Black Americans","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/acupuncture-modulates-the-microbiota-gut-brain-axis-a-novel-41322351","doi":"10.3389/fnins.2025.1710066","journal":"Frontiers in Neuroscience","n_participants":null,"pmid":"41322351","source_url":"https://pubmed.ncbi.nlm.nih.gov/41322351/","study_design":null,"title":"Acupuncture modulates the microbiota-gut-brain axis: a novel therapeutic strategy for amnestic mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/identifying-exercise-interventions-that-may-slow-the-progression-of-40255800","doi":"10.7759/cureus.80895","journal":"Cureus","n_participants":1075,"pmid":"40255800","source_url":"https://pubmed.ncbi.nlm.nih.gov/40255800/","study_design":"meta-analysis","title":"Identifying Exercise Interventions That May Slow the Progression of Cognitive Decline in Older Adults With Mild Cognitive Impairment: A Scoping Review","title_match":true,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/effects-of-intensive-lifestyle-changes-on-the-progression-of-mild-39893378","doi":"10.1186/s13195-024-01621-6","journal":"Alzheimer s Research & Therapy","n_participants":null,"pmid":"39893378","source_url":"https://pubmed.ncbi.nlm.nih.gov/39893378/","study_design":null,"title":"Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer\u2019s disease: the need for rigor","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alterations-in-gut-microbiota-and-plasma-metabolites-a-multi-omics-41404035","doi":"10.3389/fnins.2025.1667331","journal":"Frontiers in Neuroscience","n_participants":100,"pmid":"41404035","source_url":"https://pubmed.ncbi.nlm.nih.gov/41404035/","study_design":null,"title":"Alterations in gut microbiota and plasma metabolites: a multi-omics study of mild cognitive impairment in Parkinson\u2019s disease","title_match":false,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/detecting-mild-cognitive-impairment-to-alzheimers-disease-progression-42238745","doi":"10.32598/bcn.2025.2034.8","journal":"Basic and Clinical Neuroscience Journal","n_participants":null,"pmid":"42238745","source_url":"https://pubmed.ncbi.nlm.nih.gov/42238745/","study_design":null,"title":"Detecting Mild Cognitive Impairment to Alzheimer\u2019s Disease Progression by fMRI Using Convolutional Neural Network and Long-short Term Memory","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/berry-consumption-and-its-role-in-the-modulation-of-obesity-and-mild-41754191","doi":"10.3390/nu18040674","journal":"Nutrients","n_participants":null,"pmid":"41754191","source_url":"https://pubmed.ncbi.nlm.nih.gov/41754191/","study_design":"systematic review","title":"Berry Consumption and Its Role in the Modulation of Obesity and Mild Cognitive Impairment","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/moderating-role-of-triglycerides-in-the-relationship-between-amyloid-40918735","doi":"10.3389/fnagi.2025.1592341","journal":"Frontiers in Aging Neuroscience","n_participants":null,"pmid":"40918735","source_url":"https://pubmed.ncbi.nlm.nih.gov/40918735/","study_design":null,"title":"Moderating role of triglycerides in the relationship between amyloid-\u03b2, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/longitudinal-structural-mri-based-deep-learning-and-radiomics-40775357","doi":"10.1186/s13195-025-01827-2","journal":"Alzheimer s Research & Therapy","n_participants":null,"pmid":"40775357","source_url":"https://pubmed.ncbi.nlm.nih.gov/40775357/","study_design":"longitudinal study","title":"Longitudinal structural MRI-based deep learning and radiomics features for predicting Alzheimer\u2019s disease progression","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/improved-cognitive-function-efficiency-saccadic-eye-movement-and-40702818","doi":"10.1177/13872877251361033","journal":"Journal of Alzheimer s Disease","n_participants":25,"pmid":"40702818","source_url":"https://pubmed.ncbi.nlm.nih.gov/40702818/","study_design":null,"title":"Improved cognitive function, efficiency, saccadic eye movement, and depressive symptoms in mild cognitive impairment with transcranial photobiomodulation","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/multimodal-fusion-model-for-diagnosing-mild-cognitive-impairment-in-40013095","doi":"10.3389/fnagi.2025.1527323","journal":"Frontiers in Aging Neuroscience","n_participants":null,"pmid":"40013095","source_url":"https://pubmed.ncbi.nlm.nih.gov/40013095/","study_design":null,"title":"Multimodal fusion model for diagnosing mild cognitive impairment in unilateral middle cerebral artery steno-occlusive disease","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/genetic-drivers-of-hippocampal-atrophy-highlight-the-role-of-apoe-41092763","doi":"10.1016/j.nicl.2025.103889","journal":"NeuroImage Clinical","n_participants":1051,"pmid":"41092763","source_url":"https://pubmed.ncbi.nlm.nih.gov/41092763/","study_design":"longitudinal study","title":"Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/repeated-plasma-ptau217-measurements-to-monitor-clinical-progression-40442871","doi":"10.1002/alz.70319","journal":"Alzheimer s & Dementia","n_participants":186,"pmid":"40442871","source_url":"https://pubmed.ncbi.nlm.nih.gov/40442871/","study_design":"longitudinal study","title":"Repeated plasma p\u2010tau217 measurements to monitor clinical progression heterogeneity","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/predicting-mild-cognitive-impairment-to-alzheimer-s-disease-b3a80709","doi":"10.1002/ima.70390","journal":"International Journal of Imaging Systems and Technology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1002/ima.70390","study_design":null,"title":"Predicting Mild Cognitive Impairment to Alzheimer's Disease Progression by Explainable Multi\u2010Modal Framework Using Deep and Machine Learning Hybrid Model","title_match":true,"year":2026},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/effect-of-deep-brain-stimulation-on-patients-with-parkinsons-disease-41877733","doi":"10.1136/bmjno-2025-001442","journal":"BMJ Neurology Open","n_participants":984,"pmid":"41877733","source_url":"https://pubmed.ncbi.nlm.nih.gov/41877733/","study_design":"systematic review","title":"Effect of deep brain stimulation on patients with Parkinson\u2019s disease with mild cognitive impairment","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/predicting-the-beneficial-effects-of-cognitive-stimulation-and-40004217","doi":"10.3390/ijms26041754","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"40004217","source_url":"https://pubmed.ncbi.nlm.nih.gov/40004217/","study_design":null,"title":"Predicting the Beneficial Effects of Cognitive Stimulation and Transcranial Direct Current Stimulation in Amnestic Mild Cognitive Impairment with Clinical, Inflammation, and Human Microglia Exposed to Serum as Potential Markers: A Double-Blind Placebo-Controlled Randomized Clinical Trial","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/summary-of-the-best-evidence-for-non-pharmaceutical-interventions-for-40677685","doi":"10.3389/fneur.2025.1598974","journal":"Frontiers in Neurology","n_participants":null,"pmid":"40677685","source_url":"https://pubmed.ncbi.nlm.nih.gov/40677685/","study_design":"meta-analysis","title":"Summary of the best evidence for non-pharmaceutical interventions for mild cognitive impairment in Parkinson\u2019s disease","title_match":false,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/clinical-and-biological-significance-of-neuroinflammation-indicators-6b8dea37","doi":"10.30629/2618-6667-2025-23-4-36-47","journal":"Psikhiatriya","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.30629/2618-6667-2025-23-4-36-47","study_design":null,"title":"Clinical and Biological Significance of Neuroinflammation Indicators to Predict the Course of Amnestic Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/family-caregiver-perspectives-on-administering-home-based-stimulation-41834385","doi":"10.1177/13872877261429857","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"41834385","source_url":"https://pubmed.ncbi.nlm.nih.gov/41834385/","study_design":null,"title":"Family caregiver perspectives on administering home-based stimulation in patients with mild cognitive impairment","title_match":false,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/metabolomics-and-lipidomics-study-on-serum-metabolite-signatures-in-41453218","doi":"10.1002/alz70856_104134","journal":"Alzheimer s & Dementia","n_participants":22,"pmid":"41453218","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12742914/","study_design":null,"title":"Metabolomics and lipidomics study on serum metabolite signatures in Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/nomogram-for-predicting-changes-in-cognitive-function-in-community-40012456","doi":"10.4040/jkan.24059","journal":"Journal of Korean Academy of Nursing","n_participants":1262,"pmid":"40012456","source_url":"https://pubmed.ncbi.nlm.nih.gov/40012456/","study_design":"longitudinal study","title":"Nomogram for predicting changes in cognitive function in community dwelling older adults with mild cognitive impairment based on Korea Longitudinal Study of Ageing Panel Data: a retrospective study","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/ai-powered-model-for-accurate-prediction-of-mci-to-ad-progression-41049748","doi":"10.1016/j.apsb.2025.01.027","journal":"Acta Pharmaceutica Sinica B","n_participants":null,"pmid":"41049748","source_url":"https://pubmed.ncbi.nlm.nih.gov/41049748/","study_design":"longitudinal study","title":"AI-powered model for accurate prediction of MCI-to-AD progression","title_match":true,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/application-of-upper-limb-multimodal-tasks-combined-with-fnirs-40364662","doi":"10.1002/jbio.202500020","journal":"Journal of Biophotonics","n_participants":null,"pmid":"40364662","source_url":"https://pubmed.ncbi.nlm.nih.gov/40364662/","study_design":null,"title":"Application of Upper Limb Multimodal Tasks Combined With fNIRS Technology in the Assessment of Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/epigenomic-aberrations-of-histone-methylation-in-prefrontal-cortex-of-41560705","doi":"10.1177/13872877251414887","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"41560705","source_url":"https://pubmed.ncbi.nlm.nih.gov/41560705/","study_design":null,"title":"Epigenomic aberrations of histone methylation in prefrontal cortex of humans with mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/blood-uric-acid-in-mild-cognitive-impairment-a-cross-sectional-study-40607161","doi":"10.2147/ndt.s521296","journal":"Neuropsychiatric Disease and Treatment","n_participants":231,"pmid":"40607161","source_url":"https://pubmed.ncbi.nlm.nih.gov/40607161/","study_design":"cross-sectional","title":"Blood Uric Acid in Mild Cognitive Impairment: A Cross-Sectional Study of Older Chinese Adults","title_match":false,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/conversion-to-mild-cognitive-impairment-and-alzheimers-disease-40227643","doi":"10.1177/08919887251335002","journal":"Journal of Geriatric Psychiatry and Neurology","n_participants":null,"pmid":"40227643","source_url":"https://pubmed.ncbi.nlm.nih.gov/40227643/","study_design":null,"title":"Conversion to Mild Cognitive Impairment and Alzheimer\u2019s Disease Dementia Related to Apathy, APOE Genotype and Antidepressant Use","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-vascular-dysfunction-in-small-vessel-disease-40275856","doi":"10.1002/alz.70152","journal":"Alzheimer s & Dementia","n_participants":181,"pmid":"40275856","source_url":"https://pubmed.ncbi.nlm.nih.gov/40275856/","study_design":"cross-sectional","title":"Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/finger-tapping-and-paratonia-assessment-in-older-adults-with-and-40686487","doi":"10.1080/23279095.2025.2533205","journal":"Applied Neuropsychology Adult","n_participants":104,"pmid":"40686487","source_url":"https://pubmed.ncbi.nlm.nih.gov/40686487/","study_design":"longitudinal study","title":"Finger tapping and paratonia assessment in older adults with and without Mild cognitive impairment, motor-cognitive correlations","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/real-world-health-care-costs-and-resource-utilization-associated-with-40704847","doi":"10.18553/jmcp.2025.31.8.782","journal":"Journal of Managed Care & Specialty Pharmacy","n_participants":null,"pmid":"40704847","source_url":"https://pubmed.ncbi.nlm.nih.gov/40704847/","study_design":"cohort study","title":"Real-world health care costs and resource utilization associated with mild cognitive impairment in the United States: A retrospective cohort study of commercial and Medicare data","title_match":false,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/nanocarrier-based-drug-delivery-for-mild-cognitive-impairment-40774851","doi":"10.1016/j.biopha.2025.118381","journal":"Biomedicine & Pharmacotherapy","n_participants":null,"pmid":"40774851","source_url":"https://pubmed.ncbi.nlm.nih.gov/40774851/","study_design":null,"title":"Nanocarrier-based drug delivery for mild cognitive impairment: Extracellular vesicles and carbon nanotubes as emerging therapeutic tools","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/emotional-recognition-a-comparative-study-of-people-with-mild-40326170","doi":"10.1177/08919887251338266","journal":"Journal of Geriatric Psychiatry and Neurology","n_participants":141,"pmid":"40326170","source_url":"https://pubmed.ncbi.nlm.nih.gov/40326170/","study_design":null,"title":"Emotional Recognition: A Comparative Study of People with Mild Cognitive Impairment and Alzheimer\u2019s Disease Self-Report with Caregiver Perspectives","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/what-does-a-positive-alzheimer-disease-blood-based-biomarker-result-42081782","doi":"10.1212/wnl.0000000000214953","journal":"Neurology","n_participants":null,"pmid":"42081782","source_url":"https://pubmed.ncbi.nlm.nih.gov/42081782/","study_design":null,"title":"What Does a Positive Alzheimer Disease Blood-Based Biomarker Result Mean in People With Mild Cognitive Impairment?","title_match":false,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cognitive-tasks-for-evoking-the-p300-event-related-potential-in-42191023","doi":"10.1016/j.ijpsycho.2026.113423","journal":"International Journal of Psychophysiology","n_participants":null,"pmid":"42191023","source_url":"https://pubmed.ncbi.nlm.nih.gov/42191023/","study_design":null,"title":"Cognitive tasks for evoking the P300 event-related potential in Alzheimer's disease and mild cognitive impairment: A scoping review","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-alzheimer-s-disease-dementia-and-predictors-40261306","doi":"10.1177/13872877251333705","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40261306","source_url":"https://pubmed.ncbi.nlm.nih.gov/40261306/","study_design":"longitudinal study","title":"Mild cognitive impairment, Alzheimer's disease dementia, and predictors of driving cessation: A 7-year longitudinal prospective study","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/rates-of-clinical-progression-according-to-biological-alzheimer-s-40951978","doi":"10.1002/alz.70624","journal":"Alzheimer s & Dementia","n_participants":492,"pmid":"40951978","source_url":"https://pubmed.ncbi.nlm.nih.gov/40951978/","study_design":null,"title":"Rates of clinical progression according to biological Alzheimer's disease stages","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/dna-methylation-age-from-peripheral-blood-predicts-progression-to-40443531","doi":"10.1038/s44400-025-00007-1","journal":"npj Dementia","n_participants":null,"pmid":"40443531","source_url":"https://pubmed.ncbi.nlm.nih.gov/40443531/","study_design":"cross-sectional","title":"DNA methylation age from peripheral blood predicts progression to Alzheimer\u2019s disease, white matter disease burden, and cortical atrophy","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/blood-level-of-amyloid-tau-and-p-tau-in-mild-cognitive-impairment-and-41949144","doi":"10.25259/ijmr_2164_2025","journal":"The Indian Journal of Medical Research","n_participants":96,"pmid":"41949144","source_url":"https://pubmed.ncbi.nlm.nih.gov/41949144/","study_design":null,"title":"Blood level of \u03b2-amyloid, Tau, and p-Tau in mild cognitive impairment and Alzheimer disease: A follow up study","title_match":false,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/sensitivity-comparison-of-longitudinal-cognitive-function-indicators-41866365","doi":"10.1038/s41598-026-44192-2","journal":"Scientific Reports","n_participants":596,"pmid":"41866365","source_url":"https://pubmed.ncbi.nlm.nih.gov/41866365/","study_design":"longitudinal study","title":"Sensitivity comparison of longitudinal cognitive function indicators of Alzheimer\u2019s disease after mild cognitive impairment: a prospective cohort study","title_match":false,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/altered-face-perception-in-amnestic-mild-cognitive-impairment-40111918","doi":"10.1177/13872877251326294","journal":"Journal of Alzheimer s Disease","n_participants":32,"pmid":"40111918","source_url":"https://pubmed.ncbi.nlm.nih.gov/40111918/","study_design":null,"title":"Altered face perception in amnestic mild cognitive impairment: Evidence from representational similarity analysis of event-related potential","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/nonpharmacological-multicomponent-intervention-for-mild-cognitive-12e6dfb4","doi":"10.1186/s40814-026-01871-1","journal":"PubMed Central","n_participants":40,"pmid":null,"source_url":"https://doi.org/10.1186/s40814-026-01871-1","study_design":null,"title":"Nonpharmacological multicomponent intervention for mild cognitive impairment with a family-patient approach: protocol for the pilot clinical trial\u2014INTERCOG study","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/diagnostic-value-and-difference-of-quantitative-susceptibility-40671196","doi":"10.1097/cm9.0000000000003683","journal":"Chinese Medical Journal","n_participants":20,"pmid":"40671196","source_url":"https://pubmed.ncbi.nlm.nih.gov/40671196/","study_design":"longitudinal study","title":"Diagnostic value and difference of quantitative susceptibility mapping and voxel-based morphological analysis in patients with Alzheimer\u2019s disease and mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/ginkgo-biloba-and-longitudinal-changes-in-amyloid-pet-and-plasma-41984497","doi":"10.1177/13872877261441816","journal":"Journal of Alzheimer s Disease","n_participants":21,"pmid":"41984497","source_url":"https://pubmed.ncbi.nlm.nih.gov/41984497/","study_design":"cohort study","title":"Ginkgo biloba and longitudinal changes in amyloid PET and plasma amyloid-\u03b2 oligomerization in amyloid-positive mild cognitive impairment: A retrospective analysis","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/evaluating-the-effects-of-liraglutide-empagliflozin-and-linagliptin-40840993","doi":"10.1136/bmjopen-2024-095382","journal":"BMJ Open","n_participants":396,"pmid":"40840993","source_url":"https://pubmed.ncbi.nlm.nih.gov/40840993/","study_design":"open-label trial","title":"Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/evaluation-of-oxidative-stress-biomarkers-in-mild-cognitive-40859599","doi":"10.1080/01616412.2025.2551865","journal":"Neurological Research","n_participants":128,"pmid":"40859599","source_url":"https://pubmed.ncbi.nlm.nih.gov/40859599/","study_design":null,"title":"Evaluation of oxidative stress biomarkers in mild cognitive impairment and Alzheimer\u2019s disease: targeting dynamic thiol\u2013disulfide homeostasis and ischemia-modified albumin","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/reducing-neuroinflammation-and-risk-of-mild-cognitive-impairment-and-1cd741dd","doi":"10.3390/jdad2030027","journal":"Journal of dementia and Alzheimer's disease","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.3390/jdad2030027","study_design":"narrative review","title":"Reducing Neuroinflammation and Risk of Mild Cognitive Impairment and Alzheimer\u2019s Disease by Reducing Dietary Lipopolysaccharides, Arachidonic Acid, and Advanced Glycation End Products","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/the-role-of-magnetic-resonance-spectroscopy-mrs-41852095","doi":"10.1002/jmri.70296","journal":"Journal of Magnetic Resonance Imaging","n_participants":null,"pmid":"41852095","source_url":"https://pubmed.ncbi.nlm.nih.gov/41852095/","study_design":null,"title":"The Role of Magnetic Resonance Spectroscopy ( MRS ), Diffusion\u2010Tensor\u2010Imaging ( DTI ) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-novel-approach-to-the-prediction-of-alzheimers-disease-progression-1bc241b1","doi":"10.1109/access.2025.3548173","journal":"IEEE Access","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1109/access.2025.3548173","study_design":"longitudinal study","title":"A Novel Approach to the Prediction of Alzheimer\u2019s Disease Progression by Leveraging Neural Processes and a Transformer Encoder Model","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/sex-specific-effects-of-apolipoprotein-e-4-genotype-on-longitudinal-39924830","doi":"10.1177/13872877241313066","journal":"Journal of Alzheimer s Disease","n_participants":73,"pmid":"39924830","source_url":"https://pubmed.ncbi.nlm.nih.gov/39924830/","study_design":"longitudinal study","title":"Sex-specific effects of apolipoprotein E \u03b54 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/impact-of-vitamin-a-on-aged-peoples-cognition-and-alzheimers-disease-40341393","doi":"10.1038/s41538-025-00402-1","journal":"npj Science of Food","n_participants":1817,"pmid":"40341393","source_url":"https://pubmed.ncbi.nlm.nih.gov/40341393/","study_design":"cross-sectional","title":"Impact of vitamin A on aged people\u2019s cognition and Alzheimer\u2019s disease progression in an animal model","title_match":false,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/lcn2-of-cerebrospinal-fluid-a-potential-biomarker-for-diagnosis-and-40576449","doi":"10.1177/13872877251352411","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40576449","source_url":"https://pubmed.ncbi.nlm.nih.gov/40576449/","study_design":null,"title":"LCN2 of cerebrospinal fluid: A potential biomarker for diagnosis and disease progression in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/fdg-pet-brain-glucose-hypometabolism-predicts-alzheimer-s-disease-41089337","doi":"10.1016/j.metop.2025.100400","journal":"Metabolism Open","n_participants":1136,"pmid":"41089337","source_url":"https://pubmed.ncbi.nlm.nih.gov/41089337/","study_design":"longitudinal study","title":"FDG-PET brain glucose hypometabolism predicts Alzheimer's disease progression pathways in cognitively normal adults: A longitudinal competing risks modeling","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/neurological-and-inflammatory-biomarkers-in-csf-along-the-alzheimer-s-41442429","doi":"10.1002/alz70856_097201","journal":"Alzheimer s & Dementia","n_participants":100,"pmid":"41442429","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12733682/","study_design":null,"title":"Neurological and inflammatory biomarkers in CSF along the Alzheimer's Disease spectrum","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/cognitive-feature-evaluation-for-disease-progression-in-dementia-and-d6e5e6fc","doi":"10.1007/s12553-025-01006-1","journal":"Health and Technology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1007/s12553-025-01006-1","study_design":null,"title":"Cognitive feature evaluation for disease progression in dementia and its precursors using feature selection","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/individualized-prediction-of-clinical-progression-to-dementia-using-41339948","doi":"10.1186/s13195-025-01925-1","journal":"Alzheimer s Research & Therapy","n_participants":184,"pmid":"41339948","source_url":"https://pubmed.ncbi.nlm.nih.gov/41339948/","study_design":null,"title":"Individualized prediction of clinical progression to dementia using plasma biomarkers in non-demented elderly","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/association-between-third-ventricular-width-assessed-by-transcranial-40235770","doi":"10.21037/qims-24-1736","journal":"Quantitative Imaging in Medicine and Surgery","n_participants":null,"pmid":"40235770","source_url":"https://pubmed.ncbi.nlm.nih.gov/40235770/","study_design":null,"title":"Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson\u2019s disease with cognitive impairment and their potential to predict conversion to dementia","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/brain-age-gap-predicts-progression-to-dementia-in-scd-and-mci-41448625","doi":"10.1002/alz70856_103050","journal":"Alzheimer s & Dementia","n_participants":391,"pmid":"41448625","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740530/","study_design":null,"title":"Brain Age Gap Predicts Progression to Dementia in SCD and MCI","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/csf-acetylated-tau174-as-a-novel-diagnostic-and-prognostic-biomarker-41434517","doi":"10.1002/alz70861_108639","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41434517","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725880/","study_design":null,"title":"CSF Acetylated Tau\u2010174 as a novel diagnostic and prognostic biomarker in Frontotemporal Dementia and Alzheimer\u2019s Disease","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/pet-and-blood-biomarkers-as-predictors-of-shortterm-progression-in-41447122","doi":"10.1002/alz70856_100227","journal":"Alzheimer s & Dementia","n_participants":42,"pmid":"41447122","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12739722/","study_design":null,"title":"PET and Blood Biomarkers as Predictors of Short\u2010Term Progression in MCI and Mild Dementia: Prospective Insights from a Southeast Asian Middle\u2010Income Country","title_match":true,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/discovering-hidden-links-harnessing-similarity-network-fusion-to-be12e86b","doi":"10.1002/alz70856_105149","journal":"Alzheimer s & Dementia","n_participants":515,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_105149","study_design":null,"title":"Discovering Hidden Links: Harnessing Similarity Network Fusion to Reveal Common Clusters in Healthy Aging, Mild Cognitive Impairment, and Dementia","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/an-acetylated-tau-174-csf-biomarker-discriminates-between-tdp-43-and-41986736","doi":"10.1038/s41591-026-04341-6","journal":"Nature Medicine","n_participants":513,"pmid":"41986736","source_url":"https://pubmed.ncbi.nlm.nih.gov/41986736/","study_design":null,"title":"An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-increase-in-tdp-43-and-neurogranin-blood-levels-at-different-40518820","doi":"10.1177/13872877251350385","journal":"Journal of Alzheimer s Disease","n_participants":234,"pmid":"40518820","source_url":"https://pubmed.ncbi.nlm.nih.gov/40518820/","study_design":null,"title":"The increase in TDP-43 and neurogranin blood levels at different stages of cognitive impairment in the elderly people: A cross-sectional study","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/trajectory-of-plasma-lipidome-associated-with-the-risk-of-late-onset-40592256","doi":"10.1016/j.ebiom.2025.105826","journal":"EBioMedicine","n_participants":1393,"pmid":"40592256","source_url":"https://pubmed.ncbi.nlm.nih.gov/40592256/","study_design":"cross-sectional","title":"Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer's disease: a longitudinal cohort study","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/microglia-as-a-key-player-in-arelated-astrocyte-reactivity-41449556","doi":"10.1002/alz70856_102677","journal":"Alzheimer s & Dementia","n_participants":62,"pmid":"41449556","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740987/","study_design":null,"title":"Microglia as a key player in A\u03b2\u2010related astrocyte reactivity","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/reliable-new-biomarkers-of-mitochondrial-oxidative-stress-and-40869114","doi":"10.3390/ijms26167792","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"40869114","source_url":"https://pubmed.ncbi.nlm.nih.gov/40869114/","study_design":null,"title":"Reliable New Biomarkers of Mitochondrial Oxidative Stress and Neuroinflammation in Cerebrospinal Fluid and Plasma from Alzheimer\u2019s Disease Patients: A Pilot Study","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/the-role-of-gfap-as-a-marker-of-astrocyte-activation-in-the-d3e2c144","doi":"10.47134/phms.v3i1.519","journal":"Health & Medical Sciences","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.47134/phms.v3i1.519","study_design":null,"title":"The Role of GFAP as a Marker of Astrocyte Activation in the Pathogenesis of Alzheimer's Dementia: A Literature Review","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/retinal-ganglion-cell-vulnerability-to-pathogenic-tau-in-alzheimers-39955563","doi":"10.1186/s40478-025-01935-y","journal":"Acta Neuropathologica Communications","n_participants":null,"pmid":"39955563","source_url":"https://pubmed.ncbi.nlm.nih.gov/39955563/","study_design":null,"title":"Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/synaptosomalassociated-protein-25-kda-snap25-levels-in-cerebrospinal-39912369","doi":"10.1002/syn.70010","journal":"Synapse","n_participants":187,"pmid":"39912369","source_url":"https://pubmed.ncbi.nlm.nih.gov/39912369/","study_design":null,"title":"Synaptosomal\u2010Associated Protein 25 kDA (SNAP\u201025) Levels in Cerebrospinal Fluid: Implications for Alzheimer's Disease Diagnosis and Monitoring","title_match":false,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-basics-we-all-should-know-40639927","doi":"10.1080/01616412.2025.2529560","journal":"Neurological Research","n_participants":null,"pmid":"40639927","source_url":"https://pubmed.ncbi.nlm.nih.gov/40639927/","study_design":null,"title":"Alzheimer\u2019s disease basics: we all should know","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-polyphenols-and-neuroprotection-mechanistic-41470875","doi":"10.3390/nu17243929","journal":"Nutrients","n_participants":null,"pmid":"41470875","source_url":"https://pubmed.ncbi.nlm.nih.gov/41470875/","study_design":"narrative review","title":"Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/beneficial-effects-of-olive-oil-and-the-mediterranean-diet-on-42075568","doi":"10.3390/medicina62040696","journal":"Medicina","n_participants":null,"pmid":"42075568","source_url":"https://pubmed.ncbi.nlm.nih.gov/42075568/","study_design":"narrative review","title":"Beneficial Effects of Olive Oil and the Mediterranean Diet on Alzheimer\u2019s Disease and Vascular Dementia: A Review","title_match":false,"year":2026},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/cognitive-training-with-adaptive-algorithm-improves-cognitive-ability-39751703","doi":"10.1007/s40520-024-02913-5","journal":"Aging Clinical and Experimental Research","n_participants":null,"pmid":"39751703","source_url":"https://pubmed.ncbi.nlm.nih.gov/39751703/","study_design":null,"title":"Cognitive training with adaptive algorithm improves cognitive ability in older people with MCI","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/impact-of-multidomain-lifestyle-intervention-on-dynamics-of-cognitive-41397903","doi":"10.1093/gerona/glaf275","journal":"The Journals of Gerontology Series A","n_participants":401,"pmid":"41397903","source_url":"https://pubmed.ncbi.nlm.nih.gov/41397903/","study_design":null,"title":"Impact of multidomain lifestyle intervention on dynamics of cognitive frailty: post hoc analysis of the FINGER trial","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/adherence-to-the-mediterranean-diet-inflammatory-biomarkers-and-42137865","doi":"10.3389/fnut.2026.1809163","journal":"Frontiers in Nutrition","n_participants":37,"pmid":"42137865","source_url":"https://pubmed.ncbi.nlm.nih.gov/42137865/","study_design":"cross-sectional","title":"Adherence to the Mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adults","title_match":false,"year":2026},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/unlocking-cognitive-potential-exploring-a-virtual-environment-for-4e21a0da","doi":"10.1016/j.irbm.2025.100885","journal":"IRBM","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.irbm.2025.100885","study_design":null,"title":"Unlocking Cognitive Potential: Exploring a Virtual Environment for Cognitive Training in Healthy Aging and Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neurovascular-decoupling-is-associated-with-lobar-intracerebral-39950450","doi":"10.1161/jaha.124.038819","journal":"Journal of the American Heart Association","n_participants":119,"pmid":"39950450","source_url":"https://pubmed.ncbi.nlm.nih.gov/39950450/","study_design":null,"title":"Neurovascular Decoupling Is Associated With Lobar Intracerebral Hemorrhages and White Matter Hyperintensities","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/effects-of-regional-white-matter-hyperintensities-and-amyloid-on-40561557","doi":"10.1016/j.bandc.2025.106332","journal":"Brain and Cognition","n_participants":523,"pmid":"40561557","source_url":"https://pubmed.ncbi.nlm.nih.gov/40561557/","study_design":null,"title":"Effects of regional white matter hyperintensities and \u03b2-amyloid on domain-specific cognition and progression to dementia","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/progressive-structural-alterations-in-the-cerebral-small-vessel-40899970","doi":"10.1177/13872877251372953","journal":"Journal of Alzheimer s Disease","n_participants":26,"pmid":"40899970","source_url":"https://pubmed.ncbi.nlm.nih.gov/40899970/","study_design":"longitudinal study","title":"Progressive structural alterations in the cerebral small vessel disease with cognitive impairment and vascular dementia","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/wmh-dualtasker-a-weakly-supervised-deep-learning-model-for-automated-40260707","doi":"10.1002/hbm.70212","journal":"Human Brain Mapping","n_participants":60,"pmid":"40260707","source_url":"https://pubmed.ncbi.nlm.nih.gov/40260707/","study_design":null,"title":"WMH \u2010 DualTasker : A Weakly Supervised Deep Learning Model for Automated White Matter Hyperintensities Segmentation and Visual Rating Prediction","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-blood-biomarkers-reveal-proteomic-modules-of-ab713afc","doi":"10.64898/2026.08.14.26360394","journal":"medRxiv (preprint)","n_participants":11042,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.14.26360394","study_design":null,"title":"Alzheimers disease blood biomarkers reveal proteomic modules of disease progression","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/deep-multimodal-clustering-identifies-biological-subtypes-of-normal-a064c939","doi":"10.64898/2026.08.18.26360683","journal":"medRxiv (preprint)","n_participants":1136,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.18.26360683","study_design":"prospective cohort","title":"Deep multimodal clustering identifies biological subtypes of normal aging with divergent cognitive decline risk","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/mri-derived-brain-aging-trajectories-across-the-alzheimer-s-continuum-ad82dff0","doi":"10.64898/2026.08.19.26360525","journal":"medRxiv (preprint)","n_participants":202,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.19.26360525","study_design":"longitudinal study","title":"MRI-derived brain aging trajectories across the Alzheimer's continuum: links to cognition, pathology and lifestyle risk factors","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/region-specific-cerebral-blood-flow-differentiates-cognitively-79f3be3a","doi":"10.64898/2026.08.22.26361093","journal":"medRxiv (preprint)","n_participants":500,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.22.26361093","study_design":"cohort study","title":"Region-specific cerebral blood flow differentiates cognitively impaired and unimpaired individuals with core Alzheimer's disease pathology","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/explainable-deep-learning-reveals-distributed-neurodegeneration-300ee1e9","doi":"10.64898/2026.08.24.26361256","journal":"medRxiv (preprint)","n_participants":1756,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.24.26361256","study_design":null,"title":"Explainable Deep Learning Reveals Distributed Neurodegeneration Signatures of Neuropsychiatric Symptoms Across the Alzheimer's Continuum","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/treatment-response-biomarkers-in-early-alzheimers-disease-59d29669","doi":"10.64898/2026.08.27.26361425","journal":"medRxiv (preprint)","n_participants":65,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.27.26361425","study_design":"longitudinal study","title":"Treatment response biomarkers in early Alzheimers disease: longitudinal trajectories, sample size estimates, and the impact of progression variability","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/systematic-modality-ablation-of-multimodal-machine-learning-for-c0e87325","doi":"10.64898/2026.09.01.26360413","journal":"medRxiv (preprint)","n_participants":2430,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.01.26360413","study_design":null,"title":"Systematic Modality Ablation of Multimodal Machine Learning for Predicting 24-Month Progression from Mild Cognitive Impairment to Alzheimer's Disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/comparative-value-of-cognitive-and-functional-assessments-for-4acee6a6","doi":"10.64898/2026.09.01.26360561","journal":"medRxiv (preprint)","n_participants":2430,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.01.26360561","study_design":null,"title":"Comparative Value of Cognitive and Functional Assessments for Predicting 24-Month Progression from Mild Cognitive Impairment to Alzheimer's Disease: An ADNI Cohort Study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/predicting-conversion-from-scd-to-mci-a-machine-learning-study-13d655ad","doi":"10.64898/2026.09.04.26362240","journal":"medRxiv (preprint)","n_participants":1352,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.04.26362240","study_design":"longitudinal study","title":"Predicting Conversion from SCD to MCI: A Machine Learning Study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/structural-functional-and-cognitive-validation-of-a-deep-learning-mci-bb8c3259","doi":"10.64898/2026.09.05.26362318","journal":"medRxiv (preprint)","n_participants":40,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.05.26362318","study_design":"longitudinal study","title":"Structural, Functional and Cognitive Validation of a Deep-Learning MCI-to-AD Conversion Model in OASIS-3","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/development-and-external-validation-of-a-plasma-p-tau217-based-model-54b6b226","doi":"10.64898/2026.09.15.26363045","journal":"medRxiv (preprint)","n_participants":401,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.15.26363045","study_design":null,"title":"Development and External Validation of a Plasma p-tau217-Based Model for MCI-to-Dementia Progression","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-longitudinal-change-in-age-and-7bb89a73","doi":"10.64898/2026.09.11.26362869","journal":"medRxiv (preprint)","n_participants":818,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.11.26362869","study_design":"cross-sectional","title":"Association of plasma biomarkers with longitudinal change in age- and Alzheimer's disease-related brain atrophy patterns","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/long-term-value-of-lecanemab-to-individuals-and-families-40895811","doi":"10.1002/trc2.70151","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"40895811","source_url":"https://pubmed.ncbi.nlm.nih.gov/40895811/","study_design":null,"title":"Long-term value of lecanemab to individuals and families","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-blood-based-biomarker-testing-a-stakeholder-40170393","doi":"10.1177/13872877251329394","journal":"Journal of Alzheimer's disease : JAD","n_participants":12,"pmid":"40170393","source_url":"https://pubmed.ncbi.nlm.nih.gov/40170393/","study_design":null,"title":"Alzheimer's disease blood-based biomarker testing: A stakeholder-informed assessment of coverage considerations","title_match":false,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-update-how-the-amyloid-landscape-is-changing-in-light-39532491","doi":"10.2967/jnmt.124.268329","journal":"Journal of nuclear medicine technology","n_participants":null,"pmid":"39532491","source_url":"https://pubmed.ncbi.nlm.nih.gov/39532491/","study_design":null,"title":"Amyloid Imaging Update: How the Amyloid Landscape Is Changing in Light of the Recent Food and Drug Administration Approval of Antiamyloid Therapeutics","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/instrumental-activities-of-daily-living-in-older-adults-with-epilepsy-42704320","doi":"10.1002/epi.70478","journal":"Epilepsia","n_participants":22,"pmid":"42704320","source_url":"https://pubmed.ncbi.nlm.nih.gov/42704320/","study_design":"longitudinal study","title":"Instrumental activities of daily living in older adults with epilepsy: A cross-sectional and longitudinal multicenter study","title_match":false,"year":2026},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarker-signature-in-alzheimer-s-disease-19296504","doi":"10.1002/ana.21610","journal":"Annals of Neurology","n_participants":null,"pmid":"19296504","source_url":"https://pubmed.ncbi.nlm.nih.gov/19296504/","study_design":null,"title":"Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects","title_match":false,"year":2009},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/prediction-of-ad-with-mri-based-hippocampal-volume-in-mild-cognitive-10227624","doi":"10.1212/wnl.52.7.1397","journal":"Neurology","n_participants":null,"pmid":"10227624","source_url":"https://pubmed.ncbi.nlm.nih.gov/10227624/","study_design":"longitudinal study","title":"Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment","title_match":false,"year":1999},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/copper-subtype-of-alzheimer-s-disease-ad-meta-analyses-genetic-25066791","doi":"10.1016/j.jtemb.2014.06.018","journal":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","n_participants":null,"pmid":"25066791","source_url":"https://pubmed.ncbi.nlm.nih.gov/25066791/","study_design":"meta-analysis","title":"Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD","title_match":true,"year":2014},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/association-of-soluble-trem2-with-alzheimer-s-disease-and-mild-38841103","doi":"10.3389/fnagi.2024.1407980","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"38841103","source_url":"https://pubmed.ncbi.nlm.nih.gov/38841103/","study_design":"systematic review","title":"Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis","title_match":false,"year":2024},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/plasma-gfap-outperforms-csf-gfap-in-detecting-amyloid-pathology-and-41905188","doi":"10.1016/j.tjpad.2026.100544","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41905188","source_url":"https://pubmed.ncbi.nlm.nih.gov/41905188/","study_design":"longitudinal study","title":"Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mapping-the-research-landscape-of-mild-cognitive-impairment-in-41001154","doi":"10.3389/fnagi.2025.1624420","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"41001154","source_url":"https://pubmed.ncbi.nlm.nih.gov/41001154/","study_design":"systematic review","title":"Mapping the research landscape of Mild Cognitive Impairment in Parkinson's disease: a bibliometric and visualization analysis","title_match":false,"year":2025},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/neuroinflammatory-fluid-biomarkers-in-patients-with-alzheimer-s-40050444","doi":"10.1038/s41380-025-02939-9","journal":"Molecular psychiatry","n_participants":null,"pmid":"40050444","source_url":"https://pubmed.ncbi.nlm.nih.gov/40050444/","study_design":"meta-analysis","title":"Neuroinflammatory fluid biomarkers in patients with Alzheimer's disease: a systematic literature review","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/post-hoc-analysis-of-adamant-a-phase-2-clinical-trial-of-active-tau-39580468","doi":"10.1186/s13195-024-01620-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"39580468","source_url":"https://pubmed.ncbi.nlm.nih.gov/39580468/","study_design":"post-hoc analysis","title":"Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer's disease, positive for plasma p-tau217","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-association-between-circulating-inflammatory-markers-and-the-31414991","doi":"10.1097/wad.0000000000000342","journal":"Alzheimer disease and associated disorders","n_participants":88,"pmid":"31414991","source_url":"https://pubmed.ncbi.nlm.nih.gov/31414991/","study_design":null,"title":"The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia","title_match":true,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/a-randomized-open-label-clinical-trial-in-mild-cognitive-impairment-37012306","doi":"10.1038/s41598-023-32515-6","journal":"Scientific reports","n_participants":50,"pmid":"37012306","source_url":"https://pubmed.ncbi.nlm.nih.gov/37012306/","study_design":"open-label trial","title":"A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/increased-plasma-levels-of-lipocalin-2-in-mild-cognitive-impairment-21463871","doi":"10.1016/j.jns.2011.03.023","journal":"Journal of the neurological sciences","n_participants":62,"pmid":"21463871","source_url":"https://pubmed.ncbi.nlm.nih.gov/21463871/","study_design":"clinical trial","title":"Increased plasma levels of lipocalin 2 in mild cognitive impairment","title_match":false,"year":2011},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/fibrillar-amyloid-burden-in-cognitively-normal-people-at-3-levels-of-19346482","doi":"10.1073/pnas.0900345106","journal":"Proceedings of the National Academy of Sciences","n_participants":null,"pmid":"19346482","source_url":"https://pubmed.ncbi.nlm.nih.gov/19346482/","study_design":null,"title":"Fibrillar amyloid-\u03b2 burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-ten-years-later-20008648","doi":"10.1001/archneurol.2009.266","journal":"Archives of Neurology","n_participants":null,"pmid":"20008648","source_url":"https://pubmed.ncbi.nlm.nih.gov/20008648/","study_design":null,"title":"Mild cognitive impairment: ten years later","title_match":false,"year":2009},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/pet-imaging-of-amyloid-deposition-in-patients-with-mild-cognitive-17499392","doi":"10.1016/j.neurobiolaging.2007.03.029","journal":"Neurobiology of Aging","n_participants":null,"pmid":"17499392","source_url":"https://pubmed.ncbi.nlm.nih.gov/17499392/","study_design":null,"title":"PET imaging of amyloid deposition in patients with mild cognitive impairment","title_match":false,"year":2008},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-can-fdg-pet-predict-who-is-to-rapidly-12707450","doi":"10.1212/01.wnl.0000055847.17752.e6","journal":"Neurology","n_participants":null,"pmid":"12707450","source_url":"https://pubmed.ncbi.nlm.nih.gov/12707450/","study_design":null,"title":"Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?","title_match":true,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-cerebrospinal-fluid-biomarkers-in-mild-cognitive-33143865","doi":"10.1016/j.nrl.2020.07.026","journal":"Neurologia","n_participants":null,"pmid":"33143865","source_url":"https://pubmed.ncbi.nlm.nih.gov/33143865/","study_design":null,"title":"Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease","title_match":false,"year":2020},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-and-prediction-of-clinical-progression-of-01fa071e","doi":"10.1101/2020.07.15.20154237","journal":"Molecular psychiatry","n_participants":1000,"pmid":null,"source_url":"https://doi.org/10.1101/2020.07.15.20154237","study_design":"longitudinal study","title":"Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer\u2019s Disease Neuroimaging Initiative","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/brain-fluorodeoxyglucose-fdg-pet-in-dementia-26876244","doi":"10.1016/j.arr.2016.02.003","journal":"Ageing research reviews","n_participants":null,"pmid":"26876244","source_url":"https://pubmed.ncbi.nlm.nih.gov/26876244/","study_design":null,"title":"Brain fluorodeoxyglucose (FDG) PET in dementia","title_match":false,"year":2016},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/molecular-pathophysiology-of-impaired-glucose-metabolism-27233446","doi":"10.1016/j.mad.2016.05.005","journal":"Mechanisms of ageing and development","n_participants":null,"pmid":"27233446","source_url":"https://pubmed.ncbi.nlm.nih.gov/27233446/","study_design":null,"title":"Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain","title_match":false,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/hypersynchronization-in-mild-cognitive-impairment-the-x-model-31633176","doi":"10.1093/brain/awz320","journal":"Brain : a journal of neurology","n_participants":27,"pmid":"31633176","source_url":"https://pubmed.ncbi.nlm.nih.gov/31633176/","study_design":"longitudinal study","title":"Hypersynchronization in mild cognitive impairment: the 'X' model","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/microrna-based-biomarkers-in-alzheimer-s-disease-ad-33192270","doi":"10.3389/fnins.2020.585432","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"33192270","source_url":"https://pubmed.ncbi.nlm.nih.gov/33192270/","study_design":null,"title":"microRNA-Based Biomarkers in Alzheimer's Disease (AD)","title_match":false,"year":2020},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/computerized-cognitive-training-in-older-adults-with-mild-cognitive-27838936","doi":"10.1176/appi.ajp.2016.16030360","journal":"The American journal of psychiatry","n_participants":null,"pmid":"27838936","source_url":"https://pubmed.ncbi.nlm.nih.gov/27838936/","study_design":"meta-analysis","title":"Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis","title_match":false,"year":2017},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/cognitive-intervention-programs-for-individuals-with-mild-cognitive-20220584","doi":"10.1097/jgp.0b013e3181c37ce9","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":193,"pmid":"20220584","source_url":"https://pubmed.ncbi.nlm.nih.gov/20220584/","study_design":null,"title":"Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature","title_match":false,"year":2010},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/the-mediterranean-diet-is-not-related-to-cognitive-change-in-a-large-21937919","doi":"10.1097/jgp.0b013e31823032a9","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":1528,"pmid":"21937919","source_url":"https://pubmed.ncbi.nlm.nih.gov/21937919/","study_design":"longitudinal study","title":"The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cognitive-exercise-and-its-role-in-cognitive-function-in-older-adults-20425306","doi":"10.1007/s11920-009-0085-y","journal":"Current psychiatry reports","n_participants":null,"pmid":"20425306","source_url":"https://pubmed.ncbi.nlm.nih.gov/20425306/","study_design":null,"title":"Cognitive exercise and its role in cognitive function in older adults","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-in-parkinson-s-disease-and-dementia-with-lewy-26411499","doi":"10.1016/j.parkreldis.2015.09.034","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"26411499","source_url":"https://pubmed.ncbi.nlm.nih.gov/26411499/","study_design":null,"title":"Cognitive impairment in Parkinson's disease and dementia with Lewy bodies","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/positive-effects-of-computer-based-cognitive-training-in-adults-with-22525705","doi":"10.1016/j.neuropsychologia.2012.04.012","journal":"Neuropsychologia","n_participants":null,"pmid":"22525705","source_url":"https://pubmed.ncbi.nlm.nih.gov/22525705/","study_design":null,"title":"Positive effects of computer-based cognitive training in adults with mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/lifestyle-related-factors-in-predementia-and-dementia-syndromes-18088206","doi":"10.1586/14737175.8.1.133","journal":"Expert review of neurotherapeutics","n_participants":null,"pmid":"18088206","source_url":"https://pubmed.ncbi.nlm.nih.gov/18088206/","study_design":"longitudinal study","title":"Lifestyle-related factors in predementia and dementia syndromes","title_match":false,"year":2008},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/changes-in-everyday-function-in-individuals-with-psychometrically-17661957","doi":"10.1111/j.1532-5415.2007.01245.x","journal":"Journal of the American Geriatrics Society","n_participants":2358,"pmid":"17661957","source_url":"https://pubmed.ncbi.nlm.nih.gov/17661957/","study_design":"longitudinal study","title":"Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study","title_match":false,"year":2007},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/approach-to-cognitive-impairment-in-parkinson-s-disease-33205381","doi":"10.1007/s13311-020-00963-x","journal":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","n_participants":null,"pmid":"33205381","source_url":"https://pubmed.ncbi.nlm.nih.gov/33205381/","study_design":null,"title":"Approach to Cognitive Impairment in Parkinson's Disease","title_match":false,"year":2020},{"alzhub_score":88,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-mild-cognitive-impairment-and-mediterranean-diet-34682764","doi":"10.3390/jcm10204642","journal":"Journal of clinical medicine","n_participants":12458,"pmid":"34682764","source_url":"https://pubmed.ncbi.nlm.nih.gov/34682764/","study_design":"systematic review","title":"Alzheimer's Disease, Mild Cognitive Impairment and Mediterranean Diet. A Systematic Review and Dose-Response Meta-Analysis","title_match":false,"year":2021},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/efficacy-of-a-cognitive-intervention-program-in-patients-with-mild-23414646","doi":"10.1017/s1041610213000045","journal":"International psychogeriatrics","n_participants":24,"pmid":"23414646","source_url":"https://pubmed.ncbi.nlm.nih.gov/23414646/","study_design":null,"title":"Efficacy of a cognitive intervention program in patients with mild cognitive impairment","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-in-predementia-and-dementia-syndromes-21605047","doi":"10.2174/156720511796391809","journal":"Current Alzheimer research","n_participants":null,"pmid":"21605047","source_url":"https://pubmed.ncbi.nlm.nih.gov/21605047/","study_design":null,"title":"Mediterranean diet in predementia and dementia syndromes","title_match":false,"year":2011},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/cognitive-intervention-programmes-on-patients-affected-by-mild-20082051","doi":"10.1007/s12603-010-0006-0","journal":"The journal of nutrition, health & aging","n_participants":null,"pmid":"20082051","source_url":"https://pubmed.ncbi.nlm.nih.gov/20082051/","study_design":null,"title":"Cognitive intervention programmes on patients affected by Mild Cognitive Impairment: a promising intervention tool for MCI?","title_match":false,"year":2010},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/effectiveness-of-computerized-cognitive-training-in-delaying-36301590","doi":"10.2196/38624","journal":"Journal of medical Internet research","n_participants":1059,"pmid":"36301590","source_url":"https://pubmed.ncbi.nlm.nih.gov/36301590/","study_design":"systematic review","title":"Effectiveness of Computerized Cognitive Training in Delaying Cognitive Function Decline in People With Mild Cognitive Impairment: Systematic Review and Meta-analysis","title_match":false,"year":2022},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-efficacy-of-cognitive-training-for-elderly-chinese-individuals-31886216","doi":"10.1155/2019/4347281","journal":"BioMed research international","n_participants":70,"pmid":"31886216","source_url":"https://pubmed.ncbi.nlm.nih.gov/31886216/","study_design":null,"title":"The Efficacy of Cognitive Training for Elderly Chinese Individuals with Mild Cognitive Impairment","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/transition-from-mild-cognitive-impairment-to-normal-cognition-34482637","doi":"10.1002/alz.12448","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":985,"pmid":"34482637","source_url":"https://pubmed.ncbi.nlm.nih.gov/34482637/","study_design":null,"title":"Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi-state Markov models","title_match":false,"year":2022},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-effect-of-mindfulness-based-stress-reduction-mbsr-on-depression-32848377","doi":"10.2147/cia.s249196","journal":"Clinical interventions in aging","n_participants":12,"pmid":"32848377","source_url":"https://pubmed.ncbi.nlm.nih.gov/32848377/","study_design":null,"title":"The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study","title_match":false,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/a-computer-based-cognitive-training-in-mild-cognitive-impairment-in-31256092","doi":"10.3233/nre-192714","journal":"NeuroRehabilitation","n_participants":null,"pmid":"31256092","source_url":"https://pubmed.ncbi.nlm.nih.gov/31256092/","study_design":null,"title":"A computer-based cognitive training in Mild Cognitive Impairment in Parkinson's Disease","title_match":false,"year":2019},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/a-double-blind-randomized-controlled-trial-of-the-efficacy-of-32895890","doi":"10.1007/s40520-020-01665-2","journal":"Aging clinical and experimental research","n_participants":53,"pmid":"32895890","source_url":"https://pubmed.ncbi.nlm.nih.gov/32895890/","study_design":"randomized controlled trial","title":"A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool","title_match":false,"year":2021},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/effectiveness-of-online-based-cognitive-intervention-in-community-36468299","doi":"10.1002/gps.5853","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"36468299","source_url":"https://pubmed.ncbi.nlm.nih.gov/36468299/","study_design":"meta-analysis","title":"Effectiveness of online-based cognitive intervention in community-dwelling older adults with cognitive dysfunction: A systematic review and meta-analysis","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/strategies-for-the-use-of-ginkgo-biloba-extract-egb-761-sup-sup-in-33352000","doi":"10.1111/cns.13536","journal":"CNS neuroscience & therapeutics","n_participants":null,"pmid":"33352000","source_url":"https://pubmed.ncbi.nlm.nih.gov/33352000/","study_design":null,"title":"Strategies for the use of Ginkgo biloba extract, EGb 761\u00ae , in the treatment and management of mild cognitive impairment in Asia: Expert consensus","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/tai-chi-enhances-cognitive-training-effects-on-delaying-cognitive-35290704","doi":"10.1002/alz.12658","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35290704","source_url":"https://pubmed.ncbi.nlm.nih.gov/35290704/","study_design":null,"title":"Tai Chi enhances cognitive training effects on delaying cognitive decline in mild cognitive impairment","title_match":false,"year":2023},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/impact-of-3-day-combined-anodal-transcranial-direct-current-32280093","doi":"10.3233/jad-191234","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"32280093","source_url":"https://pubmed.ncbi.nlm.nih.gov/32280093/","study_design":"post-hoc analysis","title":"Impact of 3-Day Combined Anodal Transcranial Direct Current Stimulation-Visuospatial Training on Object-Location Memory in Healthy Older Adults and Patients with Mild Cognitive Impairment","title_match":false,"year":2020},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/simultaneous-aerobic-exercise-and-memory-training-program-in-older-29480182","doi":"10.3233/jad-170846","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29480182","source_url":"https://pubmed.ncbi.nlm.nih.gov/29480182/","study_design":null,"title":"Simultaneous Aerobic Exercise and Memory Training Program in Older Adults with Subjective Memory Impairments","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-personalized-12-week-brain-fitness-program-for-improving-cognitive-29205251","doi":"10.14283/jpad.2016.92","journal":"The journal of prevention of Alzheimer's disease","n_participants":127,"pmid":"29205251","source_url":"https://pubmed.ncbi.nlm.nih.gov/29205251/","study_design":null,"title":"A Personalized 12-week \"Brain Fitness Program\" for Improving Cognitive Function and Increasing the Volume of Hippocampus in Elderly with Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/effects-of-multi-component-non-pharmacological-interventions-on-35839574","doi":"10.1016/j.archger.2022.104751","journal":"Archives of gerontology and geriatrics","n_participants":null,"pmid":"35839574","source_url":"https://pubmed.ncbi.nlm.nih.gov/35839574/","study_design":"systematic review","title":"Effects of multi-component non-pharmacological interventions on cognition in participants with mild cognitive impairment: A systematic review and meta-analysis","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/progression-in-vascular-cognitive-impairment-pathogenesis-30488737","doi":"10.1177/0963689718815820","journal":"Cell transplantation","n_participants":null,"pmid":"30488737","source_url":"https://pubmed.ncbi.nlm.nih.gov/30488737/","study_design":null,"title":"Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment","title_match":false,"year":2019},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/dietary-pattern-food-and-nutritional-supplement-effects-on-cognitive-37027832","doi":"10.1093/nutrit/nuad013","journal":"Nutrition reviews","n_participants":500,"pmid":"37027832","source_url":"https://pubmed.ncbi.nlm.nih.gov/37027832/","study_design":"systematic review","title":"Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/evaluation-of-available-cognitive-tools-used-to-measure-mild-34836228","doi":"10.3390/nu13113974","journal":"Nutrients","n_participants":15,"pmid":"34836228","source_url":"https://pubmed.ncbi.nlm.nih.gov/34836228/","study_design":null,"title":"Evaluation of Available Cognitive Tools Used to Measure Mild Cognitive Decline: A Scoping Review","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/synergistic-interaction-between-amyloid-and-tau-predicts-the-28024995","doi":"10.1016/j.jalz.2016.11.005","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"28024995","source_url":"https://pubmed.ncbi.nlm.nih.gov/28024995/","study_design":null,"title":"Synergistic interaction between amyloid and tau predicts the progression\u00a0to dementia","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/advance-care-planning-information-intervention-for-persons-with-mild-33052970","doi":"10.1371/journal.pone.0240684","journal":"PloS one","n_participants":40,"pmid":"33052970","source_url":"https://pubmed.ncbi.nlm.nih.gov/33052970/","study_design":null,"title":"Advance care planning information intervention for persons with mild dementia and their family caregivers: Impact on end-of-life care decision conflicts","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cpap-adherence-may-slow-1-year-cognitive-decline-in-older-adults-with-30724333","doi":"10.1111/jgs.15758","journal":"Journal of the American Geriatrics Society","n_participants":29,"pmid":"30724333","source_url":"https://pubmed.ncbi.nlm.nih.gov/30724333/","study_design":null,"title":"CPAP Adherence May Slow 1-Year Cognitive Decline in Older Adults with Mild Cognitive Impairment and Apnea","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/combining-early-markers-strongly-predicts-conversion-from-mild-18723162","doi":"10.1016/j.biopsych.2008.06.020","journal":"Biological psychiatry","n_participants":null,"pmid":"18723162","source_url":"https://pubmed.ncbi.nlm.nih.gov/18723162/","study_design":null,"title":"Combining early markers strongly predicts conversion from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2008},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/independent-predictors-of-cognitive-decline-in-healthy-elderly-persons-11939895","doi":"10.1001/archneur.59.4.601","journal":"Archives of neurology","n_participants":48,"pmid":"11939895","source_url":"https://pubmed.ncbi.nlm.nih.gov/11939895/","study_design":"cohort study","title":"Independent predictors of cognitive decline in healthy elderly persons","title_match":false,"year":2002},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/fully-automatic-hippocampus-segmentation-and-classification-in-19437497","doi":"10.1002/hipo.20626","journal":"Hippocampus","n_participants":145,"pmid":"19437497","source_url":"https://pubmed.ncbi.nlm.nih.gov/19437497/","study_design":null,"title":"Fully automatic hippocampus segmentation and classification in Alzheimer's disease and mild cognitive impairment applied on data from ADNI","title_match":false,"year":2009},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/3d-comparison-of-hippocampal-atrophy-in-amnestic-mild-cognitive-17018552","doi":"10.1093/brain/awl274","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"17018552","source_url":"https://pubmed.ncbi.nlm.nih.gov/17018552/","study_design":null,"title":"3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/automated-cross-sectional-and-longitudinal-hippocampal-volume-20230901","doi":"10.1016/j.neuroimage.2010.03.018","journal":"NeuroImage","n_participants":30,"pmid":"20230901","source_url":"https://pubmed.ncbi.nlm.nih.gov/20230901/","study_design":null,"title":"Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/multi-method-analysis-of-mri-images-in-early-diagnostics-of-alzheimer-22022397","doi":"10.1371/journal.pone.0025446","journal":"PloS one","n_participants":834,"pmid":"22022397","source_url":"https://pubmed.ncbi.nlm.nih.gov/22022397/","study_design":null,"title":"Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/early-detection-of-alzheimer-s-disease-using-mri-hippocampal-texture-26686837","doi":"10.1002/hbm.23091","journal":"Human brain mapping","n_participants":null,"pmid":"26686837","source_url":"https://pubmed.ncbi.nlm.nih.gov/26686837/","study_design":null,"title":"Early detection of Alzheimer's disease using MRI hippocampal texture","title_match":false,"year":2016},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/memory-decline-accompanies-subthreshold-amyloid-accumulation-29572282","doi":"10.1212/wnl.0000000000005354","journal":"Neurology","n_participants":13,"pmid":"29572282","source_url":"https://pubmed.ncbi.nlm.nih.gov/29572282/","study_design":"longitudinal study","title":"Memory decline accompanies subthreshold amyloid accumulation","title_match":false,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/olfactory-identification-deficits-and-mci-in-a-multi-ethnic-elderly-18963256","doi":"10.1016/j.neurobiolaging.2008.09.008","journal":"Neurobiology of aging","n_participants":571,"pmid":"18963256","source_url":"https://pubmed.ncbi.nlm.nih.gov/18963256/","study_design":"longitudinal study","title":"Olfactory identification deficits and MCI in a multi-ethnic elderly community sample","title_match":false,"year":2010},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/atrial-fibrillation-and-incidence-of-dementia-a-systematic-review-and-21383328","doi":"10.1212/wnl.0b013e31820f2e38","journal":"Neurology","n_participants":46637,"pmid":"21383328","source_url":"https://pubmed.ncbi.nlm.nih.gov/21383328/","study_design":"meta-analysis","title":"Atrial fibrillation and incidence of dementia: a systematic review and meta-analysis","title_match":false,"year":2011},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/cerebrovascular-and-brain-morphologic-correlates-of-mild-cognitive-11295996","doi":"10.1001/archneur.58.4.643","journal":"Archives of neurology","n_participants":null,"pmid":"11295996","source_url":"https://pubmed.ncbi.nlm.nih.gov/11295996/","study_design":"longitudinal study","title":"Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study","title_match":false,"year":2001},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/microrna-expression-in-extracellular-vesicles-as-a-novel-blood-based-37071449","doi":"10.1002/alz.13055","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37071449","source_url":"https://pubmed.ncbi.nlm.nih.gov/37071449/","study_design":null,"title":"MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/the-diagnostic-and-prognostic-capabilities-of-plasma-biomarkers-in-33491853","doi":"10.1002/alz.12283","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"33491853","source_url":"https://pubmed.ncbi.nlm.nih.gov/33491853/","study_design":"longitudinal study","title":"The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/the-fda-approved-anti-amyloid-monoclonal-antibodies-for-the-treatment-38017568","doi":"10.1186/s40001-023-01512-w","journal":"European journal of medical research","n_participants":4471,"pmid":"38017568","source_url":"https://pubmed.ncbi.nlm.nih.gov/38017568/","study_design":"systematic review","title":"The FDA-approved anti-amyloid-\u03b2 monoclonal antibodies for the treatment of Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/identification-of-longitudinally-dynamic-biomarkers-in-alzheimer-s-24902845","doi":"10.1186/1750-1326-9-22","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"24902845","source_url":"https://pubmed.ncbi.nlm.nih.gov/24902845/","study_design":"longitudinal study","title":"Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-and-phosphorylated-tau-181-as-biomarkers-33766131","doi":"10.1186/s13195-021-00805-8","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"33766131","source_url":"https://pubmed.ncbi.nlm.nih.gov/33766131/","study_design":null,"title":"Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-181-predicts-amyloid-status-and-conversion-37012068","doi":"10.1136/jnnp-2022-330540","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"37012068","source_url":"https://pubmed.ncbi.nlm.nih.gov/37012068/","study_design":null,"title":"Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/trajectories-of-csf-and-plasma-biomarkers-across-alzheimer-s-disease-37977432","doi":"10.1016/j.nbd.2023.106356","journal":"Neurobiology of disease","n_participants":173,"pmid":"37977432","source_url":"https://pubmed.ncbi.nlm.nih.gov/37977432/","study_design":null,"title":"Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: disease staging by NF-L, p-tau181, and GFAP","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-as-a-biomarker-for-cognitive-decline-in-34480363","doi":"10.1002/mds.28779","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"34480363","source_url":"https://pubmed.ncbi.nlm.nih.gov/34480363/","study_design":"cross-sectional","title":"Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/csf-a42-predicts-early-onset-dementia-in-parkinson-disease-24748671","doi":"10.1212/wnl.0000000000000425","journal":"Neurology","n_participants":20,"pmid":"24748671","source_url":"https://pubmed.ncbi.nlm.nih.gov/24748671/","study_design":null,"title":"CSF A\u03b242 predicts early-onset dementia in Parkinson disease","title_match":false,"year":2014},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-combined-mirna-pirna-signature-to-detect-alzheimer-s-disease-31591382","doi":"10.1038/s41398-019-0579-2","journal":"Translational psychiatry","n_participants":null,"pmid":"31591382","source_url":"https://pubmed.ncbi.nlm.nih.gov/31591382/","study_design":null,"title":"A combined miRNA-piRNA signature to detect Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-abeta42-and-abeta40-as-markers-of-cognitive-change-in-follow-20478847","doi":"10.1136/jnnp.2010.205757","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":269,"pmid":"20478847","source_url":"https://pubmed.ncbi.nlm.nih.gov/20478847/","study_design":null,"title":"Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study","title_match":false,"year":2010},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/incremental-value-of-biomarker-combinations-to-predict-progression-of-29017593","doi":"10.1186/s13195-017-0301-7","journal":"Alzheimer's research & therapy","n_participants":115,"pmid":"29017593","source_url":"https://pubmed.ncbi.nlm.nih.gov/29017593/","study_design":"cohort study","title":"Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia","title_match":true,"year":2017},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/combining-plasma-phospho-tau-and-accessible-measures-to-evaluate-35351181","doi":"10.1186/s13195-022-00990-0","journal":"Alzheimer's research & therapy","n_participants":110,"pmid":"35351181","source_url":"https://pubmed.ncbi.nlm.nih.gov/35351181/","study_design":null,"title":"Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer's dementia in mild cognitive impairment patients","title_match":true,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/serum-bdnf-as-a-potential-biomarker-of-alzheimer-s-disease-33967943","doi":"10.3389/fneur.2021.653267","journal":"Frontiers in neurology","n_participants":66,"pmid":"33967943","source_url":"https://pubmed.ncbi.nlm.nih.gov/33967943/","study_design":null,"title":"Serum BDNF as a Potential Biomarker of Alzheimer's Disease: Verification Through Assessment of Serum, Cerebrospinal Fluid, and Medial Temporal Lobe Atrophy","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/amyloid-misfolding-as-a-plasma-biomarker-indicates-risk-for-future-33357241","doi":"10.1186/s13195-020-00738-8","journal":"Alzheimer's research & therapy","n_participants":203,"pmid":"33357241","source_url":"https://pubmed.ncbi.nlm.nih.gov/33357241/","study_design":null,"title":"Amyloid-\u03b2 misfolding as a plasma biomarker indicates risk for future clinical Alzheimer's disease in individuals with subjective cognitive decline","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/plasma-microrna-biomarker-detection-for-mild-cognitive-impairment-27999671","doi":"10.1186/s40364-016-0076-1","journal":"Biomarker research","n_participants":null,"pmid":"27999671","source_url":"https://pubmed.ncbi.nlm.nih.gov/27999671/","study_design":null,"title":"Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis","title_match":false,"year":2016},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/utility-of-different-mr-modalities-in-mild-cognitive-impairment-and-18692749","doi":"10.1016/j.acra.2008.04.008","journal":"Academic radiology","n_participants":54,"pmid":"18692749","source_url":"https://pubmed.ncbi.nlm.nih.gov/18692749/","study_design":"longitudinal study","title":"Utility of different MR modalities in mild cognitive impairment and its use as a predictor of conversion to probable dementia","title_match":true,"year":2008},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-and-inflammatory-biomarkers-positively-correlate-38011580","doi":"10.1002/alz.13485","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":837,"pmid":"38011580","source_url":"https://pubmed.ncbi.nlm.nih.gov/38011580/","study_design":null,"title":"Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK-ADRC cohort","title_match":false,"year":2024},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-exhibits-sex-specific-prognostication-37639492","doi":"10.1002/alz.13454","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":163,"pmid":"37639492","source_url":"https://pubmed.ncbi.nlm.nih.gov/37639492/","study_design":"longitudinal study","title":"Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults","title_match":false,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/ccl23-a-chemokine-associated-with-progression-from-mild-cognitive-31958084","doi":"10.3233/jad-190753","journal":"Journal of Alzheimer's disease : JAD","n_participants":53,"pmid":"31958084","source_url":"https://pubmed.ncbi.nlm.nih.gov/31958084/","study_design":"cross-sectional","title":"CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/multimodal-classification-of-alzheimer-s-disease-and-mild-cognitive-21236349","doi":"10.1016/j.neuroimage.2011.01.008","journal":"NeuroImage","n_participants":null,"pmid":"21236349","source_url":"https://pubmed.ncbi.nlm.nih.gov/21236349/","study_design":null,"title":"Multimodal classification of Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2011},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/clinical-core-of-the-alzheimer-s-disease-neuroimaging-initiative-20451872","doi":"10.1016/j.jalz.2010.03.006","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":800,"pmid":"20451872","source_url":"https://pubmed.ncbi.nlm.nih.gov/20451872/","study_design":"longitudinal study","title":"Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/increase-of-brain-oxidative-stress-in-mild-cognitive-impairment-a-12056933","doi":"10.1001/archneur.59.6.972","journal":"Archives of neurology","n_participants":null,"pmid":"12056933","source_url":"https://pubmed.ncbi.nlm.nih.gov/12056933/","study_design":null,"title":"Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease","title_match":false,"year":2002},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/prediction-of-mci-to-ad-conversion-via-mri-csf-biomarkers-and-pattern-20594615","doi":"10.1016/j.neurobiolaging.2010.05.023","journal":"Neurobiology of aging","n_participants":null,"pmid":"20594615","source_url":"https://pubmed.ncbi.nlm.nih.gov/20594615/","study_design":null,"title":"Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification","title_match":true,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/intrathecal-inflammation-precedes-development-of-alzheimer-s-disease-12933918","doi":"10.1136/jnnp.74.9.1200","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":56,"pmid":"12933918","source_url":"https://pubmed.ncbi.nlm.nih.gov/12933918/","study_design":null,"title":"Intrathecal inflammation precedes development of Alzheimer's disease","title_match":false,"year":2003},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-neuroimaging-initiative-2-clinical-core-progress-26194309","doi":"10.1016/j.jalz.2015.05.005","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26194309","source_url":"https://pubmed.ncbi.nlm.nih.gov/26194309/","study_design":"longitudinal study","title":"Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/using-digital-speech-assessments-to-detect-early-signs-of-cognitive-34778869","doi":"10.3389/fdgth.2021.749758","journal":"Frontiers in digital health","n_participants":18,"pmid":"34778869","source_url":"https://pubmed.ncbi.nlm.nih.gov/34778869/","study_design":null,"title":"Using Digital Speech Assessments to Detect Early Signs of Cognitive Impairment","title_match":false,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/using-a-digital-neuro-signature-to-measure-longitudinal-individual-34168269","doi":"10.1038/s41746-021-00470-z","journal":"NPJ digital medicine","n_participants":525,"pmid":"34168269","source_url":"https://pubmed.ncbi.nlm.nih.gov/34168269/","study_design":"longitudinal study","title":"Using a Digital Neuro Signature to measure longitudinal individual-level change in Alzheimer's disease: the Altoida large cohort study","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/can-a-novel-computerized-cognitive-screening-test-provide-additional-24656838","doi":"10.1016/j.jalz.2014.01.002","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"24656838","source_url":"https://pubmed.ncbi.nlm.nih.gov/24656838/","study_design":null,"title":"Can a novel computerized cognitive screening test provide additional information for early detection of Alzheimer's disease?","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/detection-of-mild-cognitive-impairment-through-natural-language-and-34713039","doi":"10.3389/fdgth.2020.567158","journal":"Frontiers in digital health","n_participants":null,"pmid":"34713039","source_url":"https://pubmed.ncbi.nlm.nih.gov/34713039/","study_design":null,"title":"Detection of Mild Cognitive Impairment Through Natural Language and Touchscreen Typing Processing","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-use-of-a-virtual-reality-platform-for-the-assessment-of-the-32384591","doi":"10.3390/jcm9051355","journal":"Journal of clinical medicine","n_participants":null,"pmid":"32384591","source_url":"https://pubmed.ncbi.nlm.nih.gov/32384591/","study_design":null,"title":"The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG)","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/digital-cognitive-assessments-as-low-burden-markers-for-predicting-39239892","doi":"10.1002/alz.14154","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39239892","source_url":"https://pubmed.ncbi.nlm.nih.gov/39239892/","study_design":null,"title":"Digital cognitive assessments as low-burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/functional-ability-is-associated-with-higher-adherence-to-behavioral-31608773","doi":"10.1080/13854046.2019.1672792","journal":"The Clinical neuropsychologist","n_participants":272,"pmid":"31608773","source_url":"https://pubmed.ncbi.nlm.nih.gov/31608773/","study_design":null,"title":"Functional ability is associated with higher adherence to behavioral interventions in mild cognitive impairment","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/prediction-of-cognitive-decline-in-normal-elderly-subjects-with-2-18-11526211","doi":"10.1073/pnas.191044198","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":12,"pmid":"11526211","source_url":"https://pubmed.ncbi.nlm.nih.gov/11526211/","study_design":"longitudinal study","title":"Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET)","title_match":false,"year":2001},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-neuroimaging-initiative-biomarkers-as-20451875","doi":"10.1016/j.jalz.2010.03.013","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"20451875","source_url":"https://pubmed.ncbi.nlm.nih.gov/20451875/","study_design":"longitudinal study","title":"Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-studies-of-quantitative-mci-and-ad-phenotypes-in-adni-26194313","doi":"10.1016/j.jalz.2015.05.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26194313","source_url":"https://pubmed.ncbi.nlm.nih.gov/26194313/","study_design":"longitudinal study","title":"Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans","title_match":true,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/relationship-between-atrophy-and-beta-amyloid-deposition-in-alzheimer-20373343","doi":"10.1002/ana.21955","journal":"Annals of neurology","n_participants":34,"pmid":"20373343","source_url":"https://pubmed.ncbi.nlm.nih.gov/20373343/","study_design":null,"title":"Relationship between atrophy and beta-amyloid deposition in Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-in-mild-cognitive-impairment-subtypes-19475670","doi":"10.1002/ana.21598","journal":"Annals of neurology","n_participants":null,"pmid":"19475670","source_url":"https://pubmed.ncbi.nlm.nih.gov/19475670/","study_design":"longitudinal study","title":"Amyloid imaging in mild cognitive impairment subtypes","title_match":false,"year":2009},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/automatic-classification-of-patients-with-alzheimer-s-disease-from-20542124","doi":"10.1016/j.neuroimage.2010.06.013","journal":"NeuroImage","n_participants":509,"pmid":"20542124","source_url":"https://pubmed.ncbi.nlm.nih.gov/20542124/","study_design":null,"title":"Automatic classification of patients with Alzheimer's disease from structural MRI: a comparison of ten methods using the ADNI database","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/multi-modal-multi-task-learning-for-joint-prediction-of-multiple-21992749","doi":"10.1016/j.neuroimage.2011.09.069","journal":"NeuroImage","n_participants":null,"pmid":"21992749","source_url":"https://pubmed.ncbi.nlm.nih.gov/21992749/","study_design":null,"title":"Multi-modal multi-task learning for joint prediction of multiple regression and classification variables in Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/abnormal-cortical-networks-in-mild-cognitive-impairment-and-alzheimer-21124954","doi":"10.1371/journal.pcbi.1001006","journal":"PLoS computational biology","n_participants":null,"pmid":"21124954","source_url":"https://pubmed.ncbi.nlm.nih.gov/21124954/","study_design":null,"title":"Abnormal cortical networks in mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/why-pleiotropic-interventions-are-needed-for-alzheimer-s-disease-20437209","doi":"10.1007/s12035-010-8137-1","journal":"Molecular neurobiology","n_participants":null,"pmid":"20437209","source_url":"https://pubmed.ncbi.nlm.nih.gov/20437209/","study_design":null,"title":"Why pleiotropic interventions are needed for Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/pet-imaging-of-brain-amyloid-in-dementia-a-review-21905095","doi":"10.1002/gps.2640","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"21905095","source_url":"https://pubmed.ncbi.nlm.nih.gov/21905095/","study_design":null,"title":"PET imaging of brain amyloid in dementia: a review","title_match":false,"year":2011},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/donanemab-population-pharmacokinetics-amyloid-plaque-reduction-and-36805552","doi":"10.1002/cpt.2875","journal":"Clinical pharmacology and therapeutics","n_participants":null,"pmid":"36805552","source_url":"https://pubmed.ncbi.nlm.nih.gov/36805552/","study_design":null,"title":"Donanemab Population Pharmacokinetics, Amyloid Plaque Reduction, and Safety in Participants with Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/implications-of-the-approval-of-lecanemab-for-alzheimer-disease-37295957","doi":"10.1212/wnl.0000000000207438","journal":"Neurology","n_participants":null,"pmid":"37295957","source_url":"https://pubmed.ncbi.nlm.nih.gov/37295957/","study_design":"clinical trial","title":"Implications of the Approval of Lecanemab for Alzheimer Disease Patient Care: Incremental Step or Paradigm Shift?","title_match":false,"year":2023},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/monoclonal-therapy-with-lecanemab-in-the-treatment-of-mild-alzheimer-39638097","doi":"10.1016/j.arr.2024.102620","journal":"Ageing research reviews","n_participants":null,"pmid":"39638097","source_url":"https://pubmed.ncbi.nlm.nih.gov/39638097/","study_design":"systematic review","title":"Monoclonal therapy with lecanemab in the treatment of mild Alzheimer's disease: A systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/prognostic-and-predictive-factors-in-early-alzheimer-s-disease-a-38405341","doi":"10.3233/adr-230045","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"38405341","source_url":"https://pubmed.ncbi.nlm.nih.gov/38405341/","study_design":null,"title":"Prognostic and Predictive Factors in Early Alzheimer's Disease: A Systematic Review","title_match":false,"year":2024},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/the-efficacy-and-safety-of-anti-amyloid-monoclonal-antibody-versus-40316479","doi":"10.1016/j.tjpad.2025.100195","journal":"The journal of prevention of Alzheimer's disease","n_participants":8010,"pmid":"40316479","source_url":"https://pubmed.ncbi.nlm.nih.gov/40316479/","study_design":"randomized controlled trial","title":"The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lecanemab-a-second-in-class-therapy-for-the-management-of-early-38779110","doi":"10.24926/iip.v15i1.5787","journal":"Innovations in pharmacy","n_participants":null,"pmid":"38779110","source_url":"https://pubmed.ncbi.nlm.nih.gov/38779110/","study_design":null,"title":"Lecanemab: A Second in Class Therapy for the Management of Early Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/novel-tau-fragments-in-cerebrospinal-fluid-relation-to-tangle-30547227","doi":"10.1007/s00401-018-1948-2","journal":"Acta neuropathologica","n_participants":133,"pmid":"30547227","source_url":"https://pubmed.ncbi.nlm.nih.gov/30547227/","study_design":"cross-sectional","title":"Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/brain-insulin-resistance-role-in-neurodegenerative-disease-and-32175781","doi":"10.1080/13543784.2020.1738383","journal":"Expert opinion on investigational drugs","n_participants":null,"pmid":"32175781","source_url":"https://pubmed.ncbi.nlm.nih.gov/32175781/","study_design":null,"title":"Brain insulin resistance: role in neurodegenerative disease and potential for targeting","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/role-of-glucagon-like-peptide-1-receptor-agonists-in-alzheimer-s-39501255","doi":"10.1186/s12929-024-01090-x","journal":"Journal of biomedical science","n_participants":null,"pmid":"39501255","source_url":"https://pubmed.ncbi.nlm.nih.gov/39501255/","study_design":null,"title":"Role of glucagon-like peptide-1 receptor agonists in Alzheimer's disease and Parkinson's disease","title_match":false,"year":2024},{"alzhub_score":82,"alzhub_url":"https://alzhub.org/study/safety-and-efficacy-of-galantamine-in-subjects-with-mild-cognitive-18322263","doi":"10.1212/01.wnl.0000303815.69777.26","journal":"Neurology","n_participants":2048,"pmid":"18322263","source_url":"https://pubmed.ncbi.nlm.nih.gov/18322263/","study_design":null,"title":"Safety and efficacy of galantamine in subjects with mild cognitive impairment","title_match":false,"year":2008},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/antihypertensive-drugs-decrease-risk-of-alzheimer-disease-ginkgo-23911756","doi":"10.1212/wnl.0b013e3182a35228","journal":"Neurology","n_participants":1928,"pmid":"23911756","source_url":"https://pubmed.ncbi.nlm.nih.gov/23911756/","study_design":"longitudinal study","title":"Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study","title_match":false,"year":2013},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/leisure-activities-and-the-risk-of-amnestic-mild-cognitive-impairment-16467493","doi":"10.1212/01.wnl.0000202520.68987.48","journal":"Neurology","n_participants":58,"pmid":"16467493","source_url":"https://pubmed.ncbi.nlm.nih.gov/16467493/","study_design":"prospective cohort","title":"Leisure activities and the risk of amnestic mild cognitive impairment in the elderly","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/concurrent-impairments-in-sleep-and-memory-in-amnestic-mild-cognitive-22300710","doi":"10.1017/s135561771200001x","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":null,"pmid":"22300710","source_url":"https://pubmed.ncbi.nlm.nih.gov/22300710/","study_design":null,"title":"Concurrent impairments in sleep and memory in amnestic mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-prevalence-of-peripheral-and-central-hearing-impairment-and-its-25733360","doi":"10.1159/000371597","journal":"Audiology & neuro-otology","n_participants":488,"pmid":"25733360","source_url":"https://pubmed.ncbi.nlm.nih.gov/25733360/","study_design":null,"title":"The prevalence of peripheral and central hearing impairment and its relation to cognition in older adults","title_match":false,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/reliability-and-validity-of-a-computerized-neurocognitive-test-17014981","doi":"10.1016/j.acn.2006.05.007","journal":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","n_participants":1069,"pmid":"17014981","source_url":"https://pubmed.ncbi.nlm.nih.gov/17014981/","study_design":null,"title":"Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/soluble-oligomers-of-the-amyloid-beta-protein-impair-synaptic-18359102","doi":"10.1016/j.bbr.2008.02.016","journal":"Behavioural brain research","n_participants":null,"pmid":"18359102","source_url":"https://pubmed.ncbi.nlm.nih.gov/18359102/","study_design":null,"title":"Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/barriers-to-optimising-prescribing-and-deprescribing-in-older-adults-26338170","doi":"10.2174/157488471003150820150330","journal":"Current clinical pharmacology","n_participants":null,"pmid":"26338170","source_url":"https://pubmed.ncbi.nlm.nih.gov/26338170/","study_design":"narrative review","title":"Barriers to Optimising Prescribing and Deprescribing in Older Adults with Dementia: A Narrative Review","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-amnestic-mild-cognitive-impairment-and-age-18590347","doi":null,"journal":"Alternative medicine review : a journal of clinical therapeutic","n_participants":null,"pmid":"18590347","source_url":"https://pubmed.ncbi.nlm.nih.gov/18590347/","study_design":null,"title":"Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention","title_match":true,"year":2008},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/mds-task-force-on-mild-cognitive-impairment-in-parkinson-s-disease-21661055","doi":"10.1002/mds.23823","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"21661055","source_url":"https://pubmed.ncbi.nlm.nih.gov/21661055/","study_design":null,"title":"MDS Task Force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI","title_match":false,"year":2011},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/early-diagnosis-of-alzheimer-s-disease-using-cortical-thickness-19439419","doi":"10.1093/brain/awp105","journal":"Brain : a journal of neurology","n_participants":122,"pmid":"19439419","source_url":"https://pubmed.ncbi.nlm.nih.gov/19439419/","study_design":null,"title":"Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/machine-learning-framework-for-early-mri-based-alzheimer-s-conversion-25312773","doi":"10.1016/j.neuroimage.2014.10.002","journal":"NeuroImage","n_participants":null,"pmid":"25312773","source_url":"https://pubmed.ncbi.nlm.nih.gov/25312773/","study_design":null,"title":"Machine learning framework for early MRI-based Alzheimer's conversion prediction in MCI subjects","title_match":true,"year":2015},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/deep-learning-in-alzheimer-s-disease-diagnostic-classification-and-31481890","doi":"10.3389/fnagi.2019.00220","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"31481890","source_url":"https://pubmed.ncbi.nlm.nih.gov/31481890/","study_design":"systematic review","title":"Deep Learning in Alzheimer's Disease: Diagnostic Classification and Prognostic Prediction Using Neuroimaging Data","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/automated-classification-of-alzheimer-s-disease-and-mild-cognitive-30584016","doi":"10.1016/j.nicl.2018.101645","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"30584016","source_url":"https://pubmed.ncbi.nlm.nih.gov/30584016/","study_design":"cross-sectional","title":"Automated classification of Alzheimer's disease and mild cognitive impairment using a single MRI and deep neural networks","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/spatial-navigation-in-normal-aging-and-the-prodromal-stage-of-22771718","doi":"10.1016/j.arr.2012.04.007","journal":"Ageing research reviews","n_participants":null,"pmid":"22771718","source_url":"https://pubmed.ncbi.nlm.nih.gov/22771718/","study_design":null,"title":"Spatial navigation in normal aging and the prodromal stage of Alzheimer's disease: insights from imaging and behavioral studies","title_match":false,"year":2013},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/diagnostic-power-of-resting-state-fmri-for-detection-of-network-33942449","doi":"10.1002/hbm.25369","journal":"Human brain mapping","n_participants":null,"pmid":"33942449","source_url":"https://pubmed.ncbi.nlm.nih.gov/33942449/","study_design":"systematic review","title":"Diagnostic power of resting-state fMRI for detection of network connectivity in Alzheimer's disease and mild cognitive impairment: A systematic review","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/deep-learning-based-brain-age-prediction-in-normal-aging-and-dementia-37118071","doi":"10.1038/s43587-022-00219-7","journal":"Nature aging","n_participants":null,"pmid":"37118071","source_url":"https://pubmed.ncbi.nlm.nih.gov/37118071/","study_design":"longitudinal study","title":"Deep learning-based brain age prediction in normal aging and dementia","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/multimodal-and-multiscale-deep-neural-networks-for-the-early-29632364","doi":"10.1038/s41598-018-22871-z","journal":"Scientific reports","n_participants":null,"pmid":"29632364","source_url":"https://pubmed.ncbi.nlm.nih.gov/29632364/","study_design":null,"title":"Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/does-feature-selection-improve-classification-accuracy-impact-of-22166797","doi":"10.1016/j.neuroimage.2011.11.066","journal":"NeuroImage","n_participants":null,"pmid":"22166797","source_url":"https://pubmed.ncbi.nlm.nih.gov/22166797/","study_design":null,"title":"Does feature selection improve classification accuracy? Impact of sample size and feature selection on classification using anatomical magnetic resonance images","title_match":false,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/accurate-multimodal-probabilistic-prediction-of-conversion-to-24179825","doi":"10.1016/j.nicl.2013.05.004","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"24179825","source_url":"https://pubmed.ncbi.nlm.nih.gov/24179825/","study_design":null,"title":"Accurate multimodal probabilistic prediction of conversion to Alzheimer's disease in patients with mild cognitive impairment","title_match":true,"year":2013},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/convolutional-neural-networks-based-mri-image-analysis-for-the-30455622","doi":"10.3389/fnins.2018.00777","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"30455622","source_url":"https://pubmed.ncbi.nlm.nih.gov/30455622/","study_design":null,"title":"Convolutional Neural Networks-Based MRI Image Analysis for the Alzheimer's Disease Prediction From Mild Cognitive Impairment","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/ensembles-of-deep-learning-architectures-for-the-early-diagnosis-of-27478060","doi":"10.1142/s0129065716500258","journal":"International journal of neural systems","n_participants":null,"pmid":"27478060","source_url":"https://pubmed.ncbi.nlm.nih.gov/27478060/","study_design":null,"title":"Ensembles of Deep Learning Architectures for the Early Diagnosis of the Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/predicting-cognitive-decline-with-deep-learning-of-brain-metabolism-29454006","doi":"10.1016/j.bbr.2018.02.017","journal":"Behavioural brain research","n_participants":139,"pmid":"29454006","source_url":"https://pubmed.ncbi.nlm.nih.gov/29454006/","study_design":"longitudinal study","title":"Predicting cognitive decline with deep learning of brain metabolism and amyloid imaging","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/predicting-conversion-from-mci-to-ad-using-resting-state-fmri-graph-28286064","doi":"10.1016/j.jneumeth.2017.03.006","journal":"Journal of neuroscience methods","n_participants":null,"pmid":"28286064","source_url":"https://pubmed.ncbi.nlm.nih.gov/28286064/","study_design":null,"title":"Predicting conversion from MCI to AD using resting-state fMRI, graph theoretical approach and SVM","title_match":true,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/multivariate-data-analysis-and-machine-learning-in-alzheimer-s-24718104","doi":"10.3233/jad-131928","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"24718104","source_url":"https://pubmed.ncbi.nlm.nih.gov/24718104/","study_design":null,"title":"Multivariate data analysis and machine learning in Alzheimer's disease with a focus on structural magnetic resonance imaging","title_match":false,"year":2014},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/classification-of-alzheimer-s-disease-by-combination-of-convolutional-29970996","doi":"10.3389/fninf.2018.00035","journal":"Frontiers in neuroinformatics","n_participants":339,"pmid":"29970996","source_url":"https://pubmed.ncbi.nlm.nih.gov/29970996/","study_design":null,"title":"Classification of Alzheimer's Disease by Combination of Convolutional and Recurrent Neural Networks Using FDG-PET Images","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/classification-of-patients-with-mci-and-ad-from-healthy-controls-27345822","doi":"10.1016/j.bbr.2016.06.043","journal":"Behavioural brain research","n_participants":null,"pmid":"27345822","source_url":"https://pubmed.ncbi.nlm.nih.gov/27345822/","study_design":null,"title":"Classification of patients with MCI and AD from healthy controls using directed graph measures of resting-state fMRI","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/development-of-digital-voice-biomarkers-and-associations-with-36777093","doi":"10.1002/dad2.12393","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"36777093","source_url":"https://pubmed.ncbi.nlm.nih.gov/36777093/","study_design":null,"title":"Development of digital voice biomarkers and associations with cognition, cerebrospinal biomarkers, and neural representation in early Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/ad-bert-using-pre-trained-language-model-to-predict-the-progression-37429512","doi":"10.1016/j.jbi.2023.104442","journal":"Journal of biomedical informatics","n_participants":3657,"pmid":"37429512","source_url":"https://pubmed.ncbi.nlm.nih.gov/37429512/","study_design":null,"title":"AD-BERT: Using pre-trained language model to predict the progression from mild cognitive impairment to Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/neuropsychological-prediction-of-conversion-to-alzheimer-disease-in-16894068","doi":"10.1001/archpsyc.63.8.916","journal":"Archives of general psychiatry","n_participants":108,"pmid":"16894068","source_url":"https://pubmed.ncbi.nlm.nih.gov/16894068/","study_design":null,"title":"Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment","title_match":true,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-antioxidants-are-similarly-depleted-in-mild-cognitive-12928050","doi":"10.1016/s0197-4580(03)00031-9","journal":"Neurobiology of aging","n_participants":25,"pmid":"12928050","source_url":"https://pubmed.ncbi.nlm.nih.gov/12928050/","study_design":null,"title":"Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease","title_match":false,"year":2003},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-early-detection-of-alzheimer-s-disease-a-cross-40483474","doi":"10.1186/s13195-025-01778-8","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"40483474","source_url":"https://pubmed.ncbi.nlm.nih.gov/40483474/","study_design":"cross-sectional","title":"Plasma biomarkers for early detection of alzheimer's disease: a cross-sectional study in a Japanese cohort","title_match":false,"year":2025},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-p-tau217-p-tau181-and-p-tau231-42318558","doi":"10.3389/fnagi.2026.1834591","journal":"Frontiers in aging neuroscience","n_participants":4736,"pmid":"42318558","source_url":"https://pubmed.ncbi.nlm.nih.gov/42318558/","study_design":"systematic review","title":"Diagnostic performance of plasma p-Tau217, p-Tau181, and p-Tau231 across the Alzheimer's disease continuum: a network meta-analysis","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-phosphorylated-tau-217-in-patients-on-the-40725025","doi":"10.3390/ijms26146771","journal":"International journal of molecular sciences","n_participants":276,"pmid":"40725025","source_url":"https://pubmed.ncbi.nlm.nih.gov/40725025/","study_design":null,"title":"Performance of Plasma Phosphorylated tau-217 in Patients on the Continuum of Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-plasma-p-tau217-in-cognitively-unimpaired-older-42483984","doi":"10.1002/alz.71599","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1204,"pmid":"42483984","source_url":"https://pubmed.ncbi.nlm.nih.gov/42483984/","study_design":"longitudinal study","title":"Prognostic value of plasma %p-tau217 in cognitively unimpaired older adults","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/day-to-day-sleep-variability-with-alzheimer-s-biomarkers-in-at-risk-38371359","doi":"10.1002/dad2.12521","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"38371359","source_url":"https://pubmed.ncbi.nlm.nih.gov/38371359/","study_design":null,"title":"Day-to-day sleep variability with Alzheimer's biomarkers in at-risk elderly","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-p-tau-markers-vascular-factors-and-cognitive-decline-in-the-42273887","doi":"10.1002/alz.71588","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"42273887","source_url":"https://pubmed.ncbi.nlm.nih.gov/42273887/","study_design":"longitudinal study","title":"Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/serum-gfap-differentiates-alzheimer-s-disease-from-frontotemporal-35477892","doi":"10.1136/jnnp-2021-328547","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":230,"pmid":"35477892","source_url":"https://pubmed.ncbi.nlm.nih.gov/35477892/","study_design":null,"title":"Serum GFAP differentiates Alzheimer's disease from frontotemporal dementia and predicts MCI-to-dementia conversion","title_match":true,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/clinical-application-of-plasma-neurofilament-light-chain-in-a-memory-35585907","doi":"10.12779/dnd.2022.21.2.59","journal":"Dementia and neurocognitive disorders","n_participants":14,"pmid":"35585907","source_url":"https://pubmed.ncbi.nlm.nih.gov/35585907/","study_design":"longitudinal study","title":"Clinical Application of Plasma Neurofilament Light Chain in a Memory Clinic: A Pilot Study","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-neurodegeneration-in-mild-cognitive-impairment-37489795","doi":"10.1017/s0033291723001952","journal":"Psychological medicine","n_participants":55,"pmid":"37489795","source_url":"https://pubmed.ncbi.nlm.nih.gov/37489795/","study_design":null,"title":"Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/deamidation-related-blood-biomarkers-show-promise-for-early-36575499","doi":"10.1186/s40364-022-00435-8","journal":"Biomarker research","n_participants":140,"pmid":"36575499","source_url":"https://pubmed.ncbi.nlm.nih.gov/36575499/","study_design":"longitudinal study","title":"Deamidation-related blood biomarkers show promise for early diagnostics of neurodegeneration","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/cross-sectional-and-longitudinal-evaluation-of-plasma-glial-37885919","doi":"10.1002/dad2.12492","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":567,"pmid":"37885919","source_url":"https://pubmed.ncbi.nlm.nih.gov/37885919/","study_design":"cross-sectional","title":"Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/plasma-markers-of-astrocytic-and-axonal-integrity-in-idiopathic-40879604","doi":"10.1002/mds.70016","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":2004,"pmid":"40879604","source_url":"https://pubmed.ncbi.nlm.nih.gov/40879604/","study_design":"cohort study","title":"Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-diagnostic-progression-is-associated-with-41014048","doi":"10.1002/alz.70726","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":24,"pmid":"41014048","source_url":"https://pubmed.ncbi.nlm.nih.gov/41014048/","study_design":null,"title":"Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-trajectories-impact-of-ad-genetic-risk-and-clinical-40151521","doi":"10.1002/dad2.70081","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"40151521","source_url":"https://pubmed.ncbi.nlm.nih.gov/40151521/","study_design":"longitudinal study","title":"Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/association-of-plasma-alzheimer-s-disease-biomarkers-with-cognitive-40883967","doi":"10.1002/alz.70625","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":381,"pmid":"40883967","source_url":"https://pubmed.ncbi.nlm.nih.gov/40883967/","study_design":null,"title":"Association of plasma Alzheimer's disease biomarkers with cognitive decline in cognitively unimpaired individuals","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/amyloid-beta42-plasma-levels-are-elevated-in-amnestic-mild-cognitive-19584444","doi":"10.3233/jad-2009-1144","journal":"Journal of Alzheimer's disease : JAD","n_participants":191,"pmid":"19584444","source_url":"https://pubmed.ncbi.nlm.nih.gov/19584444/","study_design":null,"title":"Amyloid-beta42 plasma levels are elevated in amnestic mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/csf-neurochemical-profile-and-cognitive-changes-in-parkinson-s-37095141","doi":"10.1038/s41531-023-00509-w","journal":"NPJ Parkinson's disease","n_participants":48,"pmid":"37095141","source_url":"https://pubmed.ncbi.nlm.nih.gov/37095141/","study_design":"longitudinal study","title":"CSF neurochemical profile and cognitive changes in Parkinson's disease with mild cognitive impairment","title_match":false,"year":2023},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-trajectories-across-alzheimer-s-clinical-onset-a-17-42021299","doi":"10.1186/s13195-026-02045-0","journal":"Alzheimer's research & therapy","n_participants":17,"pmid":"42021299","source_url":"https://pubmed.ncbi.nlm.nih.gov/42021299/","study_design":"longitudinal study","title":"Plasma biomarker trajectories across Alzheimer's clinical onset: a 17-year prospective study","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-nt1-tau-is-a-specific-and-early-marker-of-alzheimer-s-disease-32829532","doi":"10.1002/ana.25885","journal":"Annals of neurology","n_participants":null,"pmid":"32829532","source_url":"https://pubmed.ncbi.nlm.nih.gov/32829532/","study_design":null,"title":"Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-novel-plasma-based-biomarker-of-alzheimer-s-disease-26401710","doi":"10.3233/jad-150183","journal":"Journal of Alzheimer's disease : JAD","n_participants":135,"pmid":"26401710","source_url":"https://pubmed.ncbi.nlm.nih.gov/26401710/","study_design":null,"title":"A Novel Plasma Based Biomarker of Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/blood-neurofilament-levels-predict-cognitive-decline-across-the-38139190","doi":"10.3390/ijms242417361","journal":"International journal of molecular sciences","n_participants":350,"pmid":"38139190","source_url":"https://pubmed.ncbi.nlm.nih.gov/38139190/","study_design":null,"title":"Blood Neurofilament Levels Predict Cognitive Decline across the Alzheimer's Disease Continuum","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/adam10-biomarker-of-mild-cognitive-impairment-but-not-of-cognitive-33675901","doi":"10.1016/j.exger.2021.111303","journal":"Experimental gerontology","n_participants":null,"pmid":"33675901","source_url":"https://pubmed.ncbi.nlm.nih.gov/33675901/","study_design":null,"title":"ADAM10: Biomarker of mild cognitive impairment but not of cognitive frailty","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/elevation-of-plasma-soluble-amyloid-precursor-protein-beta-in-31874328","doi":"10.1016/j.archger.2019.103995","journal":"Archives of gerontology and geriatrics","n_participants":null,"pmid":"31874328","source_url":"https://pubmed.ncbi.nlm.nih.gov/31874328/","study_design":null,"title":"Elevation of plasma soluble amyloid precursor protein beta in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/symptom-guided-blood-biomarker-testing-for-alzheimer-s-disease-42862762","doi":"10.1159/dem/aciag010","journal":"Dementia and geriatric cognitive disorders","n_participants":603,"pmid":"42862762","source_url":"https://pubmed.ncbi.nlm.nih.gov/42862762/","study_design":null,"title":"Symptom-Guided Blood Biomarker Testing for Alzheimer's Disease","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/developing-educational-materials-to-aid-in-alzheimer-s-blood-41262682","doi":"10.1002/trc2.70182","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"41262682","source_url":"https://pubmed.ncbi.nlm.nih.gov/41262682/","study_design":null,"title":"Developing educational materials to aid in Alzheimer's blood biomarker disclosure","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/non-beta-amyloid-tau-cerebrospinal-fluid-markers-inform-staging-and-30253800","doi":"10.1186/s13195-018-0426-3","journal":"Alzheimer's research & therapy","n_participants":31,"pmid":"30253800","source_url":"https://pubmed.ncbi.nlm.nih.gov/30253800/","study_design":"longitudinal study","title":"Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-levels-of-ykl-40-in-prodromal-alzheimer-s-disease-31794792","doi":"10.1016/j.neulet.2019.134658","journal":"Neuroscience letters","n_participants":63,"pmid":"31794792","source_url":"https://pubmed.ncbi.nlm.nih.gov/31794792/","study_design":"cross-sectional","title":"Cerebrospinal fluid levels of YKL-40 in prodromal Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-profile-of-lipid-mediators-in-alzheimer-s-disease-35362880","doi":"10.1007/s10571-022-01216-5","journal":"Cellular and molecular neurobiology","n_participants":null,"pmid":"35362880","source_url":"https://pubmed.ncbi.nlm.nih.gov/35362880/","study_design":null,"title":"Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-synuclein-predicts-neurodegeneration-and-clinical-33228804","doi":"10.1186/s40035-020-00222-1","journal":"Translational neurodegeneration","n_participants":null,"pmid":"33228804","source_url":"https://pubmed.ncbi.nlm.nih.gov/33228804/","study_design":"longitudinal study","title":"Cerebrospinal fluid \u03b1-synuclein predicts neurodegeneration and clinical progression in non-demented elders","title_match":false,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-of-cognitive-decline-in-parkinson-s-28554411","doi":"10.1016/bs.irn.2016.12.001","journal":"International review of neurobiology","n_participants":null,"pmid":"28554411","source_url":"https://pubmed.ncbi.nlm.nih.gov/28554411/","study_design":"longitudinal study","title":"Cerebrospinal Fluid Biomarkers of Cognitive Decline in Parkinson's Disease","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/exploration-of-salient-risk-factors-involved-in-mild-cognitive-35388543","doi":"10.1111/ejn.15665","journal":"The European journal of neuroscience","n_participants":null,"pmid":"35388543","source_url":"https://pubmed.ncbi.nlm.nih.gov/35388543/","study_design":null,"title":"Exploration of salient risk factors involved in mild cognitive impairment","title_match":false,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/intrinsic-functional-connectivity-csf-biomarker-profiles-and-their-31801648","doi":"10.1017/neu.2019.49","journal":"Acta neuropsychiatrica","n_participants":30,"pmid":"31801648","source_url":"https://pubmed.ncbi.nlm.nih.gov/31801648/","study_design":null,"title":"Intrinsic functional connectivity, CSF biomarker profiles and their relation to cognitive function in mild cognitive impairment","title_match":false,"year":2020},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-white-matter-hyperintensities-with-cognitive-decline-39328245","doi":"10.3389/fnagi.2024.1412735","journal":"Frontiers in aging neuroscience","n_participants":1803,"pmid":"39328245","source_url":"https://pubmed.ncbi.nlm.nih.gov/39328245/","study_design":"longitudinal study","title":"Association of white matter hyperintensities with cognitive decline and neurodegeneration","title_match":false,"year":2024},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/smartphone-based-detection-of-subtle-memory-decline-in-prodromal-42270927","doi":"10.1038/s41746-026-02731-1","journal":"NPJ digital medicine","n_participants":152,"pmid":"42270927","source_url":"https://pubmed.ncbi.nlm.nih.gov/42270927/","study_design":"longitudinal study","title":"Smartphone-based detection of subtle memory decline in prodromal Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/digital-biomarkers-based-individualized-prognosis-for-people-at-risk-32468532","doi":"10.1007/978-3-030-32622-7_14","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"32468532","source_url":"https://pubmed.ncbi.nlm.nih.gov/32468532/","study_design":null,"title":"Digital Biomarkers Based Individualized Prognosis for People at Risk of Dementia: the AltoidaML Multi-site External Validation Study","title_match":false,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/memory-driven-eye-movements-prospectively-predict-dementia-in-people-36579131","doi":"10.1002/dad2.12386","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":107,"pmid":"36579131","source_url":"https://pubmed.ncbi.nlm.nih.gov/36579131/","study_design":null,"title":"Memory-driven eye movements prospectively predict dementia in people at risk of Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/performance-and-validation-of-a-digital-memory-test-across-the-39886066","doi":"10.1093/braincomms/fcaf024","journal":"Brain communications","n_participants":325,"pmid":"39886066","source_url":"https://pubmed.ncbi.nlm.nih.gov/39886066/","study_design":null,"title":"Performance and validation of a digital memory test across the Alzheimer's disease continuum","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/polygenic-effects-on-the-risk-of-alzheimer-s-disease-in-the-japanese-38414085","doi":"10.1186/s13195-024-01414-x","journal":"Alzheimer's research & therapy","n_participants":565,"pmid":"38414085","source_url":"https://pubmed.ncbi.nlm.nih.gov/38414085/","study_design":null,"title":"Polygenic effects on the risk of Alzheimer's disease in the Japanese population","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-brain-connectivity-changes-for-31996736","doi":"10.1038/s41598-020-58291-1","journal":"Scientific reports","n_participants":null,"pmid":"31996736","source_url":"https://pubmed.ncbi.nlm.nih.gov/31996736/","study_design":"longitudinal study","title":"Genome-Wide Association Study of Brain Connectivity Changes for Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/phenome-wide-association-study-of-polygenic-risk-score-for-alzheimer-35370621","doi":"10.3389/fnagi.2022.800375","journal":"Frontiers in aging neuroscience","n_participants":1515,"pmid":"35370621","source_url":"https://pubmed.ncbi.nlm.nih.gov/35370621/","study_design":null,"title":"Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer's Disease in Electronic Health Records","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-polygenic-risk-score-as-a-predictor-of-conversion-31127079","doi":"10.1038/s41398-019-0485-7","journal":"Translational psychiatry","n_participants":122,"pmid":"31127079","source_url":"https://pubmed.ncbi.nlm.nih.gov/31127079/","study_design":null,"title":"Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/reduced-trem2-activation-in-microglia-of-patients-with-alzheimer-s-34523252","doi":"10.1002/2211-5463.13300","journal":"FEBS open bio","n_participants":null,"pmid":"34523252","source_url":"https://pubmed.ncbi.nlm.nih.gov/34523252/","study_design":null,"title":"Reduced TREM2 activation in microglia of patients with Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/multi-omic-atlas-of-the-parahippocampal-gyrus-in-alzheimer-s-disease-37684260","doi":"10.1038/s41597-023-02507-2","journal":"Scientific data","n_participants":null,"pmid":"37684260","source_url":"https://pubmed.ncbi.nlm.nih.gov/37684260/","study_design":null,"title":"Multi-omic atlas of the parahippocampal gyrus in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/affective-symptoms-and-regional-cerebral-tau-burden-in-early-stage-33682933","doi":"10.1002/gps.5530","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"33682933","source_url":"https://pubmed.ncbi.nlm.nih.gov/33682933/","study_design":"cross-sectional","title":"Affective symptoms and regional cerebral tau burden in early-stage Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/beta-amyloid-imaging-in-dementia-31620564","doi":"10.12701/yujm.2018.35.1.1","journal":"Yeungnam University journal of medicine","n_participants":null,"pmid":"31620564","source_url":"https://pubmed.ncbi.nlm.nih.gov/31620564/","study_design":null,"title":"Beta-amyloid imaging in dementia","title_match":false,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/early-detection-of-amyloid-load-using-18f-florbetaben-pet-33773598","doi":"10.1186/s13195-021-00807-6","journal":"Alzheimer's research & therapy","n_participants":287,"pmid":"33773598","source_url":"https://pubmed.ncbi.nlm.nih.gov/33773598/","study_design":null,"title":"Early detection of amyloid load using 18F-florbetaben PET","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/longitudinal-validity-of-pet-based-staging-of-regional-amyloid-32648624","doi":"10.1002/hbm.25121","journal":"Human brain mapping","n_participants":403,"pmid":"32648624","source_url":"https://pubmed.ncbi.nlm.nih.gov/32648624/","study_design":"cross-sectional","title":"Longitudinal validity of PET-based staging of regional amyloid deposition","title_match":false,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-and-amyloid-pet-concordance-and-diagnostic-accuracy-in-30847669","doi":"10.1007/s13760-019-01112-8","journal":"Acta neurologica Belgica","n_participants":31,"pmid":"30847669","source_url":"https://pubmed.ncbi.nlm.nih.gov/30847669/","study_design":null,"title":"CSF biomarkers and amyloid PET: concordance and diagnostic accuracy in a MCI cohort","title_match":false,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/default-mode-network-lateralization-and-memory-in-healthy-aging-and-30412488","doi":"10.3233/jad-180541","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"30412488","source_url":"https://pubmed.ncbi.nlm.nih.gov/30412488/","study_design":null,"title":"Default Mode Network Lateralization and Memory in Healthy Aging and Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/resting-state-fmri-changes-in-alzheimer-s-disease-and-mild-cognitive-21862179","doi":"10.1016/j.neurobiolaging.2011.07.003","journal":"Neurobiology of aging","n_participants":39,"pmid":"21862179","source_url":"https://pubmed.ncbi.nlm.nih.gov/21862179/","study_design":null,"title":"Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/resting-state-fmri-as-a-biomarker-for-alzheimer-s-disease-22423634","doi":"10.1186/alzrt106","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"22423634","source_url":"https://pubmed.ncbi.nlm.nih.gov/22423634/","study_design":"cross-sectional","title":"Resting-state fMRI as a biomarker for Alzheimer's disease?","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-pathophysiology-in-the-retina-38759947","doi":"10.1016/j.preteyeres.2024.101273","journal":"Progress in retinal and eye research","n_participants":null,"pmid":"38759947","source_url":"https://pubmed.ncbi.nlm.nih.gov/38759947/","study_design":null,"title":"Alzheimer's disease pathophysiology in the Retina","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/retinal-vasculopathy-in-alzheimer-s-disease-34630020","doi":"10.3389/fnins.2021.731614","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"34630020","source_url":"https://pubmed.ncbi.nlm.nih.gov/34630020/","study_design":null,"title":"Retinal Vasculopathy in Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/assessing-outer-retinal-and-choroidal-changes-in-scd-potential-for-41315191","doi":"10.1038/s41398-025-03781-x","journal":"Translational psychiatry","n_participants":57,"pmid":"41315191","source_url":"https://pubmed.ncbi.nlm.nih.gov/41315191/","study_design":null,"title":"Assessing outer retinal and choroidal changes in scd: potential for high-risk screening using SS-OCTA","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/ganglion-cell-layer-thinning-in-alzheimer-s-disease-33096909","doi":"10.3390/medicina56100553","journal":"Medicina (Kaunas, Lithuania)","n_participants":null,"pmid":"33096909","source_url":"https://pubmed.ncbi.nlm.nih.gov/33096909/","study_design":null,"title":"Ganglion Cell Layer Thinning in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/monoclonal-antibody-treatments-for-alzheimer-s-disease-aducanumab-and-39726673","doi":"10.15190/d.2023.12","journal":"Discoveries (Craiova, Romania)","n_participants":null,"pmid":"39726673","source_url":"https://pubmed.ncbi.nlm.nih.gov/39726673/","study_design":null,"title":"Monoclonal Antibody Treatments for Alzheimer's Disease: Aducanumab and Lecanemab","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/donanemab-for-alzheimer-s-disease-from-preclinical-research-to-the-40790925","doi":"10.1080/14737175.2025.2546868","journal":"Expert review of neurotherapeutics","n_participants":null,"pmid":"40790925","source_url":"https://pubmed.ncbi.nlm.nih.gov/40790925/","study_design":"systematic review","title":"Donanemab for Alzheimer's disease: from preclinical research to the clinical application","title_match":false,"year":2025},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/lecanemab-for-treatment-of-individuals-with-early-alzheimer-s-disease-41689888","doi":"10.1016/j.tjpad.2026.100507","journal":"The journal of prevention of Alzheimer's disease","n_participants":1795,"pmid":"41689888","source_url":"https://pubmed.ncbi.nlm.nih.gov/41689888/","study_design":"clinical trial","title":"Lecanemab for treatment of individuals with early Alzheimer's Disease (AD) who are apolipoprotein E \u03b54 (ApoE \u03b54) non-carriers or heterozygotes","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-treatment-of-cognitive-and-functional-symptoms-39283851","doi":null,"journal":"American family physician","n_participants":null,"pmid":"39283851","source_url":"https://pubmed.ncbi.nlm.nih.gov/39283851/","study_design":null,"title":"Alzheimer Disease: Treatment of Cognitive and Functional Symptoms","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/treatment-of-parkinson-s-disease-with-cognitive-impairment-current-33920698","doi":"10.3390/bs11040054","journal":"Behavioral sciences (Basel, Switzerland)","n_participants":null,"pmid":"33920698","source_url":"https://pubmed.ncbi.nlm.nih.gov/33920698/","study_design":null,"title":"Treatment of Parkinson's Disease with Cognitive Impairment: Current Approaches and Future Directions","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/metformin-new-applications-for-an-old-drug-36474458","doi":"10.1515/jbcpp-2022-0252","journal":"Journal of basic and clinical physiology and pharmacology","n_participants":null,"pmid":"36474458","source_url":"https://pubmed.ncbi.nlm.nih.gov/36474458/","study_design":null,"title":"Metformin: new applications for an old drug","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-25-year-evolution-of-lithium-as-a-disease-modifying-agent-in-42268602","doi":"10.1001/jamapsychiatry.2026.1296","journal":"JAMA psychiatry","n_participants":null,"pmid":"42268602","source_url":"https://pubmed.ncbi.nlm.nih.gov/42268602/","study_design":null,"title":"The 25-Year Evolution of Lithium as a Disease-Modifying Agent in Dementia: A Narrative Review","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/lithium-a-therapeutic-option-in-alzheimer-s-disease-and-its-prodromal-34119602","doi":"10.1016/j.neulet.2021.136044","journal":"Neuroscience letters","n_participants":null,"pmid":"34119602","source_url":"https://pubmed.ncbi.nlm.nih.gov/34119602/","study_design":null,"title":"Lithium: A therapeutic option in Alzheimer's disease and its prodromal stages?","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mechanism-of-action-and-clinical-trial-results-of-lecanemab-leqembi-38692883","doi":"10.1254/fpj.24005","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","n_participants":null,"pmid":"38692883","source_url":"https://pubmed.ncbi.nlm.nih.gov/38692883/","study_design":null,"title":"[Mechanism of action and clinical trial results of Lecanemab (Leqembi\u00ae 200 \u200dmg, 500 \u200dmg for Intravenous Infusion), a novel treatment for Alzheimer's disease]","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/ambroxol-as-a-disease-modifying-treatment-to-reduce-the-risk-of-38027469","doi":"10.1136/bmjno-2023-000535","journal":"BMJ neurology open","n_participants":null,"pmid":"38027469","source_url":"https://pubmed.ncbi.nlm.nih.gov/38027469/","study_design":"open-label trial","title":"Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment in GBA-associated Parkinson's disease: a multicentre, randomised, double-blind, placebo-controlled, phase II trial. The AMBITIOUS study protocol","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/risk-reduction-and-precision-prevention-across-the-alzheimer-s-41145344","doi":"10.1016/j.tjpad.2025.100367","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41145344","source_url":"https://pubmed.ncbi.nlm.nih.gov/41145344/","study_design":null,"title":"Risk reduction and precision prevention across the Alzheimer's disease continuum: a systematic review of clinical trials combining multidomain lifestyle interventions and pharmacological or nutraceutical approaches","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/impaired-parahippocampal-gyrus-orbitofrontal-cortex-circuit-32350798","doi":"10.1007/s12264-020-00498-3","journal":"Neuroscience bulletin","n_participants":null,"pmid":"32350798","source_url":"https://pubmed.ncbi.nlm.nih.gov/32350798/","study_design":null,"title":"Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease","title_match":false,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/sleep-and-neurodegeneration-42544975","doi":"10.1212/cont.0000000000001734","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"42544975","source_url":"https://pubmed.ncbi.nlm.nih.gov/42544975/","study_design":null,"title":"Sleep and Neurodegeneration","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/sleep-physiology-and-disorders-in-aging-and-dementia-31753150","doi":"10.1016/b978-0-12-804766-8.00026-1","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"31753150","source_url":"https://pubmed.ncbi.nlm.nih.gov/31753150/","study_design":null,"title":"Sleep physiology and disorders in aging and dementia","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/obstructive-sleep-apnea-and-dementia-a-role-to-play-37633736","doi":"10.1016/j.neurol.2023.08.006","journal":"Revue neurologique","n_participants":null,"pmid":"37633736","source_url":"https://pubmed.ncbi.nlm.nih.gov/37633736/","study_design":null,"title":"Obstructive sleep apnea and dementia: A role to play?","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/associations-between-sleep-duration-and-cognitive-impairment-in-mild-31006940","doi":"10.1111/jsr.12864","journal":"Journal of sleep research","n_participants":50,"pmid":"31006940","source_url":"https://pubmed.ncbi.nlm.nih.gov/31006940/","study_design":null,"title":"Associations between sleep duration and cognitive impairment in mild cognitive impairment","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/metabolic-syndrome-and-cognitive-function-34668083","doi":"10.1007/s11886-021-01615-y","journal":"Current cardiology reports","n_participants":null,"pmid":"34668083","source_url":"https://pubmed.ncbi.nlm.nih.gov/34668083/","study_design":"cross-sectional","title":"Metabolic Syndrome and Cognitive Function","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cardiometabolic-and-vascular-disease-factors-and-mild-cognitive-35081540","doi":"10.1159/000521547","journal":"Gerontology","n_participants":null,"pmid":"35081540","source_url":"https://pubmed.ncbi.nlm.nih.gov/35081540/","study_design":"longitudinal study","title":"Cardiometabolic and Vascular Disease Factors and Mild Cognitive Impairment and Dementia","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/later-onset-hypertension-is-associated-with-higher-risk-of-dementia-33324316","doi":"10.3389/fneur.2020.557977","journal":"Frontiers in neurology","n_participants":null,"pmid":"33324316","source_url":"https://pubmed.ncbi.nlm.nih.gov/33324316/","study_design":"longitudinal study","title":"Later-Onset Hypertension Is Associated With Higher Risk of Dementia in Mild Cognitive Impairment","title_match":false,"year":2020},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/cognitive-reserve-and-cortical-thickness-in-preclinical-alzheimer-s-27544202","doi":"10.1007/s11682-016-9581-y","journal":"Brain imaging and behavior","n_participants":232,"pmid":"27544202","source_url":"https://pubmed.ncbi.nlm.nih.gov/27544202/","study_design":"longitudinal study","title":"Cognitive reserve and cortical thickness in preclinical Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/sex-specific-brain-reserve-and-progression-from-mild-cognitive-42869847","doi":"10.1002/alz.71913","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":593,"pmid":"42869847","source_url":"https://pubmed.ncbi.nlm.nih.gov/42869847/","study_design":"longitudinal study","title":"Sex-specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia","title_match":true,"year":2026},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/effect-of-cognitive-reserve-on-cognitive-function-in-parkinson-s-35230598","doi":"10.1007/s10072-022-05985-1","journal":"Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology","n_participants":null,"pmid":"35230598","source_url":"https://pubmed.ncbi.nlm.nih.gov/35230598/","study_design":"meta-analysis","title":"Effect of cognitive reserve on cognitive function in Parkinson's disease","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/late-life-depression-cognitive-impairment-and-relationship-with-34823241","doi":"10.1159/000519453","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"34823241","source_url":"https://pubmed.ncbi.nlm.nih.gov/34823241/","study_design":"cross-sectional","title":"Late-Life Depression, Cognitive Impairment, and Relationship with Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/diagnosis-and-treatment-of-depression-and-cognitive-impairment-in-25655026","doi":"10.1111/nyas.12669","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"25655026","source_url":"https://pubmed.ncbi.nlm.nih.gov/25655026/","study_design":null,"title":"Diagnosis and treatment of depression and cognitive impairment in late life","title_match":false,"year":2015},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/perceived-social-isolation-is-correlated-with-brain-structure-and-35526259","doi":"10.1007/s11357-022-00584-6","journal":"GeroScience","n_participants":23,"pmid":"35526259","source_url":"https://pubmed.ncbi.nlm.nih.gov/35526259/","study_design":"longitudinal study","title":"Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-and-dementia-involving-multiple-cognitive-30909241","doi":"10.3233/jad-181208","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"30909241","source_url":"https://pubmed.ncbi.nlm.nih.gov/30909241/","study_design":null,"title":"Mild Cognitive Impairment and Dementia Involving Multiple Cognitive Domains in Mexican Urbanites","title_match":false,"year":2019},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/efficacy-of-mediterranean-diet-for-the-prevention-of-neurological-41259881","doi":"10.1016/j.nut.2025.112990","journal":"Nutrition (Burbank, Los Angeles County, Calif.)","n_participants":null,"pmid":"41259881","source_url":"https://pubmed.ncbi.nlm.nih.gov/41259881/","study_design":"systematic review","title":"Efficacy of Mediterranean diet for the prevention of neurological diseases: A systematic review and meta-analysis featured in the Italian National Guidelines \"La Dieta Mediterranea\"","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-role-of-nutrition-in-the-prevention-of-cognitive-decline-38001066","doi":"10.1097/mco.0000000000001002","journal":"Current opinion in clinical nutrition and metabolic care","n_participants":null,"pmid":"38001066","source_url":"https://pubmed.ncbi.nlm.nih.gov/38001066/","study_design":null,"title":"The role of nutrition in the prevention of cognitive decline","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/omega-3-fatty-acids-increase-oxphos-energy-for-immune-therapy-of-32614485","doi":"10.1096/fj.202000669rr","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"32614485","source_url":"https://pubmed.ncbi.nlm.nih.gov/32614485/","study_design":null,"title":"Omega-3 fatty acids increase OXPHOS energy for immune therapy of Alzheimer disease patients","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/identification-of-chlamydia-pneumoniae-and-nlrp3-inflammasome-41571675","doi":"10.1038/s41467-026-68580-4","journal":"Nature communications","n_participants":null,"pmid":"41571675","source_url":"https://pubmed.ncbi.nlm.nih.gov/41571675/","study_design":null,"title":"Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/the-gut-brain-axis-in-alzheimer-s-disease-early-detection-microbial-42325435","doi":"10.3389/fmolb.2026.1735332","journal":"Frontiers in molecular biosciences","n_participants":null,"pmid":"42325435","source_url":"https://pubmed.ncbi.nlm.nih.gov/42325435/","study_design":"longitudinal study","title":"The gut-brain axis in Alzheimer's disease: early detection, microbial metabolites, mechanisms, and therapeutic opportunities","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-brief-overview-of-a-mouse-model-of-cerebral-hypoperfusion-by-36883344","doi":"10.1177/0271678x231154597","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"36883344","source_url":"https://pubmed.ncbi.nlm.nih.gov/36883344/","study_design":null,"title":"A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis","title_match":false,"year":2023},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/misfolded-alpha-synuclein-co-occurrence-with-alzheimer-s-disease-39417113","doi":"10.1101/2024.10.11.24315349","journal":"medRxiv : the preprint server for health sciences","n_participants":420,"pmid":"39417113","source_url":"https://pubmed.ncbi.nlm.nih.gov/39417113/","study_design":"longitudinal study","title":"Misfolded alpha synuclein co-occurrence with Alzheimer's disease proteinopathy","title_match":false,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/misfolded-synuclein-co-occurrence-with-alzheimer-s-disease-40356020","doi":"10.1002/alz.70205","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":420,"pmid":"40356020","source_url":"https://pubmed.ncbi.nlm.nih.gov/40356020/","study_design":"longitudinal study","title":"Misfolded \u03b1-synuclein co-occurrence with Alzheimer's disease proteinopathy","title_match":false,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-csf-synuclein-seed-amplification-assay-positivity-with-39428831","doi":"10.1002/alz.14276","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1637,"pmid":"39428831","source_url":"https://pubmed.ncbi.nlm.nih.gov/39428831/","study_design":"cross-sectional","title":"Association of CSF \u03b1-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/early-retinal-uchl1-dysregulation-coupled-with-synaptic-loss-reflects-42666080","doi":"10.1002/advs.202600020","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","n_participants":null,"pmid":"42666080","source_url":"https://pubmed.ncbi.nlm.nih.gov/42666080/","study_design":null,"title":"Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-emtbr-tau-as-a-marker-of-clinical-stage-and-progression-across-935d5a9a","doi":"10.64898/2026.10.21.26366056","journal":"medRxiv","n_participants":436,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.21.26366056","study_design":"cohort study","title":"Plasma eMTBR-tau as a marker of clinical stage and progression across the Alzheimer\u2019s disease continuum","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/tau-pet-subtype-modifies-the-association-between-plasma-p-tau217-and-ada7a142","doi":"10.64898/2026.09.25.26363629","journal":"medRxiv","n_participants":396,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.25.26363629","study_design":"cross-sectional","title":"Tau-PET subtype modifies the association between plasma p-tau217 and memory in Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-digital-biomarker-of-white-matter-routing-from-diffusion-mri-as-an-717b639d","doi":"10.64898/2026.10.21.26366165","journal":"medRxiv","n_participants":609,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.21.26366165","study_design":null,"title":"A digital biomarker of white-matter routing from diffusion MRI as an early biomarker of Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/initial-technical-and-clinical-validation-of-mobile-pupillometry-with-bd891c91","doi":"10.64898/2026.07.15.26358187","journal":"medRxiv","n_participants":43,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.15.26358187","study_design":null,"title":"Initial Technical and Clinical Validation of Mobile Pupillometry with Virtual Reality: A Digital Biomarker for Screening Cognitive Function and Impairment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/tau-ctfp-a-connectome-informed-continuous-time-first-passage-model-05365979","doi":"10.64898/2026.10.26.761855","journal":"bioRxiv","n_participants":168,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.26.761855","study_design":null,"title":"Tau-CTFP: A connectome-informed continuous-time first-passage model for forecasting the onset of regional tau PET abnormality","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/current-gaps-in-downstream-applications-of-fmri-foundation-models-51eea5af","doi":"10.64898/2026.10.22.26366227","journal":"medRxiv","n_participants":343,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.22.26366227","study_design":null,"title":"Current gaps in downstream applications of fMRI foundation models: lessons learned from BrainLM & BrainHarmonix on Prevent-AD","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/determining-the-metabolic-profile-measured-using-ultra-high-pressure-fe58168b","doi":"10.21203/rs.3.rs-10065374/v1","journal":"Research Square","n_participants":59,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10065374/v1","study_design":null,"title":"Determining the metabolic profile measured using ultra-high pressure liquid chromatography associated with Beta Amyloid burden in the brain in individuals with mild cognitive impairment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/longitudinal-associations-between-neuropsychiatric-symptoms-74862252","doi":"10.64898/2026.10.15.26364284","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.15.26364284","study_design":"longitudinal study","title":"Longitudinal associations between neuropsychiatric symptoms, structural and perfusion MRI changes in older adults with Mild Cognitive Impairment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/pre-dementia-clinical-trajectories-associated-with-neuronal-synuclein-434cc4bc","doi":"10.21203/rs.3.rs-10788306/v1","journal":"Research Square","n_participants":1543,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10788306/v1","study_design":"longitudinal study","title":"Pre-dementia clinical trajectories associated with neuronal \u03b1-synuclein neuropathologic change: a retrospective cohort study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/treatment-of-obstructive-sleep-apnea-may-contribute-to-long-term-41e84190","doi":"10.21203/rs.3.rs-10502651/v1","journal":"Research Square","n_participants":86,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10502651/v1","study_design":"cohort study","title":"Treatment of obstructive sleep apnea may contribute to long-term stabilisation of memory in Alzheimer's and vascular dementia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/navigating-life-after-dementia-diagnosis-questions-challenges-and-927d909f","doi":"10.64898/2026.10.07.26364992","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.07.26364992","study_design":null,"title":"Navigating Life After Dementia Diagnosis: Questions, Challenges, and Support Needs Among Dementia Dyads","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/comparator-supplement-patterns-qualify-the-clinical-interpretation-of-086b7a5e","doi":"10.64898/2026.07.23.26358748","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.23.26358748","study_design":null,"title":"Comparator supplement patterns qualify the clinical interpretation of an EHR-derived glucosamine signal in Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/upper-cervical-spinal-cord-morphometric-charts-from-population-1d881181","doi":"10.64898/2026.10.09.26364862","journal":"medRxiv","n_participants":2394,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.09.26364862","study_design":null,"title":"Upper cervical spinal cord morphometric charts: from population references to individualized clinical assessment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/reducing-neutrophil-sialic-acid-residues-alleviates-cerebral-94d50e55","doi":"10.64898/2026.09.23.753660","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.23.753660","study_design":null,"title":"Reducing Neutrophil Sialic Acid Residues Alleviates Cerebral Hypoperfusion in Alzheimer\u2019s Models","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/lithium-therapy-and-delayed-progression-of-alzheimers-disease-and-20b0989e","doi":"10.64898/2026.01.12.26343472","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.12.26343472","study_design":null,"title":"Lithium therapy and delayed progression of Alzheimer\u2019s disease and related dementias in patients with bipolar disorder and mild neurocognitive disorders","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/machine-learning-on-subcortical-brain-features-a-study-of-sample-size-36cb393a","doi":"10.64898/2026.09.15.751847","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.15.751847","study_design":null,"title":"Machine learning on subcortical brain features: A study of sample size efficiency for neurodegenerative disease classification","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/early-prediction-of-parkinsons-disease-progression-by-integrating-5ca208fc","doi":"10.64898/2026.07.07.26357483","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.07.26357483","study_design":"longitudinal study","title":"Early Prediction of Parkinson\u2019s Disease Progression by Integrating Research Cohort and Real-World Data Using Knowledge-Anchored Graph Learning","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/paths-of-aging-minds-health-journeys-of-older-adults-with-mild-2356de84","doi":"10.21203/rs.3.rs-11366061/v1","journal":"Research Square","n_participants":10489,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11366061/v1","study_design":"cohort study","title":"Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/neuro-jepa-building-and-evaluating-health-system-scale-neuroimaging-e8078740","doi":"10.21203/rs.3.rs-11130462/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11130462/v1","study_design":null,"title":"Neuro-JEPA: Building and Evaluating Health-System Scale Neuroimaging Foundation Models with Mixture of Experts","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/explainable-machine-learning-identifies-predictors-for-postural-b5a66a6c","doi":"10.64898/2026.09.30.26364120","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.30.26364120","study_design":null,"title":"Explainable machine learning identifies predictors for postural instability and cognitive impairment in early Parkinson\u2019s Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/digital-and-health-literacy-are-associated-with-health-related-0779adb1","doi":"10.21203/rs.3.rs-10562861/v1","journal":"Research Square","n_participants":121,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10562861/v1","study_design":"cross-sectional","title":"Digital and Health Literacy Are Associated with Health-Related Quality of Life Across Cognitive Impairment Stages in Older Adults","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/heterogeneity-in-multimodal-ai-feature-engineering-utility-for-ef7df3b7","doi":"10.31234/osf.io/s58bj_v1","journal":"PsyArXiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.31234/osf.io/s58bj_v1","study_design":null,"title":"Heterogeneity in Multimodal AI Feature Engineering Utility for Explaining Change in Dementia","title_match":false,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/prediction-of-alzheimers-disease-using-the-csf-a42-a40-ratio-in-17374949","doi":"10.1159/000100926","journal":"Dementia and Geriatric Cognitive Disorders","n_participants":137,"pmid":"17374949","source_url":"https://pubmed.ncbi.nlm.nih.gov/17374949/","study_design":null,"title":"Prediction of Alzheimer\u2019s Disease Using the CSF A\u03b242/A\u03b240 Ratio in Patients with Mild Cognitive Impairment","title_match":false,"year":2007},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/gwas-of-longitudinal-amyloid-accumulation-on18f-florbetapir-pet-in-26268530","doi":"10.1093/brain/awv231","journal":"Brain","n_participants":null,"pmid":"26268530","source_url":"https://pubmed.ncbi.nlm.nih.gov/26268530/","study_design":"longitudinal study","title":"GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer\u2019s disease implicates microglial activation geneIL1RAP","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/classification-and-visualization-of-alzheimers-disease-using-31796817","doi":"10.1038/s41598-019-54548-6","journal":"Scientific Reports","n_participants":null,"pmid":"31796817","source_url":"https://pubmed.ncbi.nlm.nih.gov/31796817/","study_design":null,"title":"Classification and Visualization of Alzheimer\u2019s Disease using Volumetric Convolutional Neural Network and Transfer Learning","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/pharmacologic-therapy-for-type-2-diabetes-mellitus-af75a470","doi":"10.7326/0003-4819-133-1-200007040-00016","journal":"Annals of Internal Medicine","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.7326/0003-4819-133-1-200007040-00016","study_design":"systematic review","title":"Pharmacologic Therapy for Type 2 Diabetes Mellitus","title_match":false,"year":2000},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/neuropsychological-measures-predict-decline-to-alzheimer-s-dementia-22612573","doi":"10.1037/a0028576","journal":"Neuropsychology","n_participants":106,"pmid":"22612573","source_url":"https://pubmed.ncbi.nlm.nih.gov/22612573/","study_design":"longitudinal study","title":"Neuropsychological measures predict decline to Alzheimer's dementia from mild cognitive impairment","title_match":false,"year":2012},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-as-a-clinical-entity-and-treatment-target-16009779","doi":"10.1001/archneur.62.7.1160","journal":"Archives of Neurology","n_participants":null,"pmid":"16009779","source_url":"https://pubmed.ncbi.nlm.nih.gov/16009779/","study_design":"longitudinal study","title":"Mild Cognitive Impairment as a Clinical Entity and Treatment Target","title_match":false,"year":2005},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau181-with-memory-decline-in-non-demented-cf62d2ac","doi":"10.1093/braincomms/fcab136","journal":"Brain Communications","n_participants":604,"pmid":null,"source_url":"https://doi.org/10.1093/braincomms/fcab136","study_design":"longitudinal study","title":"Association of plasma P-tau181 with memory decline in non-demented adults","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau181-predicts-cognitive-and-functional-decline-68271e02","doi":"10.1002/acn3.51695","journal":"Annals of Clinical and Translational Neurology","n_participants":91,"pmid":null,"source_url":"https://doi.org/10.1002/acn3.51695","study_design":null,"title":"Plasma phosphorylated tau181 predicts cognitive and functional decline","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/electroencephalographic-finding-in-idiopathic-rem-sleep-behavior-b7fa48f7","doi":"10.1159/000363343","journal":"Neuropsychobiology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1159/000363343","study_design":"longitudinal study","title":"Electroencephalographic Finding in Idiopathic REM Sleep Behavior Disorder","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/pon-1-and-ferroxidase-activities-in-older-patients-with-mild-40e45779","doi":"10.1515/cclm-2014-0803","journal":"Clinical Chemistry and Laboratory Medicine (CCLM)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1515/cclm-2014-0803","study_design":"longitudinal study","title":"PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer\u2019s disease or vascular dementia","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lower-cerebrospinal-fluid-concentration-of-brain-derived-neurotrophic-26138246","doi":"10.1007/s12017-015-8361-y","journal":"Neuromolecular medicine","n_participants":128,"pmid":"26138246","source_url":"https://pubmed.ncbi.nlm.nih.gov/26138246/","study_design":null,"title":"Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer's Disease","title_match":true,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/clinical-value-of-plasma-alzpath-ptau217-immunoassay-for-assessing-38658136","doi":"10.1136/jnnp-2024-333467","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"38658136","source_url":"https://pubmed.ncbi.nlm.nih.gov/38658136/","study_design":null,"title":"Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/cognitive-variability-predicts-incident-alzheimer-s-disease-and-mild-29125485","doi":"10.3233/jad-170498","journal":"Journal of Alzheimer's disease : JAD","n_participants":105,"pmid":"29125485","source_url":"https://pubmed.ncbi.nlm.nih.gov/29125485/","study_design":"longitudinal study","title":"Cognitive Variability Predicts Incident Alzheimer's Disease and Mild Cognitive Impairment Comparable to a Cerebrospinal Fluid Biomarker","title_match":false,"year":2018},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/matrix-metalloproteinase-10-is-linked-to-the-risk-of-progression-to-35088840","doi":"10.1093/brain/awac024","journal":"Brain : a journal of neurology","n_participants":410,"pmid":"35088840","source_url":"https://pubmed.ncbi.nlm.nih.gov/35088840/","study_design":"longitudinal study","title":"Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type","title_match":false,"year":2022},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau181-with-memory-decline-in-non-demented-34222875","doi":"10.1093/braincomms/fcab136","journal":"Brain communications","n_participants":604,"pmid":"34222875","source_url":"https://pubmed.ncbi.nlm.nih.gov/34222875/","study_design":"longitudinal study","title":"Association of plasma P-tau181 with memory decline in non-demented adults","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-efficacy-of-plasma-biomarkers-in-early-diagnosis-of-alzheimer-s-24318929","doi":"10.1002/gps.4053","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"24318929","source_url":"https://pubmed.ncbi.nlm.nih.gov/24318929/","study_design":null,"title":"The efficacy of plasma biomarkers in early diagnosis of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/predictive-value-of-cerebrospinal-fluid-visinin-like-protein-1-levels-26836160","doi":"10.3233/jad-150705","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26836160","source_url":"https://pubmed.ncbi.nlm.nih.gov/26836160/","study_design":null,"title":"Predictive Value of Cerebrospinal Fluid Visinin-Like Protein-1 Levels for Alzheimer's Disease Early Detection and Differential Diagnosis in Patients with Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/longitudinal-cerebrospinal-fluid-tau-load-increases-in-mild-cognitive-12429378","doi":"10.1016/s0304-3940(02)01038-8","journal":"Neuroscience letters","n_participants":null,"pmid":"12429378","source_url":"https://pubmed.ncbi.nlm.nih.gov/12429378/","study_design":"cross-sectional","title":"Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment","title_match":false,"year":2002},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/changes-in-csf-spdgfr-level-and-their-association-with-blood-brain-36915135","doi":"10.1186/s13195-023-01199-5","journal":"Alzheimer's research & therapy","n_participants":158,"pmid":"36915135","source_url":"https://pubmed.ncbi.nlm.nih.gov/36915135/","study_design":null,"title":"Changes in CSF sPDGFR\u03b2 level and their association with blood-brain barrier breakdown in Alzheimer's disease with or without small cerebrovascular lesions","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/acute-phase-markers-in-csf-reveal-inflammatory-changes-in-alzheimer-s-32882319","doi":"10.1016/j.pneurobio.2020.101904","journal":"Progress in neurobiology","n_participants":1291,"pmid":"32882319","source_url":"https://pubmed.ncbi.nlm.nih.gov/32882319/","study_design":null,"title":"Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE \u03b54, sex and age","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/multimodal-prediction-of-dementia-with-up-to-10-years-follow-up-the-25201779","doi":"10.3233/jad-141053","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25201779","source_url":"https://pubmed.ncbi.nlm.nih.gov/25201779/","study_design":null,"title":"Multimodal prediction of dementia with up to 10 years follow up: the Gothenburg MCI study","title_match":false,"year":2015},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/associations-between-plasma-biomarkers-and-cognition-in-patients-with-31698867","doi":"10.3390/jcm8111893","journal":"Journal of clinical medicine","n_participants":40,"pmid":"31698867","source_url":"https://pubmed.ncbi.nlm.nih.gov/31698867/","study_design":"cross-sectional","title":"Associations between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study","title_match":false,"year":2019},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-longitudinal-study-of-total-and-phosphorylated-synuclein-with-other-29376878","doi":"10.3233/jad-171013","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29376878","source_url":"https://pubmed.ncbi.nlm.nih.gov/29376878/","study_design":"longitudinal study","title":"A Longitudinal Study of Total and Phosphorylated \u03b1-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment","title_match":false,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/biomarker-discovery-in-alzheimer-s-and-neurodegenerative-diseases-40401628","doi":"10.1002/alz.14621","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40401628","source_url":"https://pubmed.ncbi.nlm.nih.gov/40401628/","study_design":null,"title":"Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau181-predicts-cognitive-and-functional-decline-36518085","doi":"10.1002/acn3.51695","journal":"Annals of clinical and translational neurology","n_participants":91,"pmid":"36518085","source_url":"https://pubmed.ncbi.nlm.nih.gov/36518085/","study_design":null,"title":"Plasma phosphorylated tau181 predicts cognitive and functional decline","title_match":false,"year":2023},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/dissociable-contribution-of-plasma-nfl-and-p-tau181-to-cognitive-35752549","doi":"10.1016/j.parkreldis.2022.05.020","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"35752549","source_url":"https://pubmed.ncbi.nlm.nih.gov/35752549/","study_design":"prospective cohort","title":"Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/low-levels-of-cerebrospinal-fluid-complement-3-and-factor-h-predict-25478014","doi":"10.1186/alzrt266","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"25478014","source_url":"https://pubmed.ncbi.nlm.nih.gov/25478014/","study_design":"longitudinal study","title":"Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment","title_match":false,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/csf-ferritin-in-the-clinicopathological-progression-of-alzheimer-s-36357168","doi":"10.1136/jnnp-2022-330052","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"36357168","source_url":"https://pubmed.ncbi.nlm.nih.gov/36357168/","study_design":"longitudinal study","title":"CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkers","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/dysregulation-of-ruminococcaceae-and-megamonas-could-be-predictive-37543169","doi":"10.1016/j.micpath.2023.106272","journal":"Microbial pathogenesis","n_participants":1013,"pmid":"37543169","source_url":"https://pubmed.ncbi.nlm.nih.gov/37543169/","study_design":null,"title":"Dysregulation of Ruminococcaceae and Megamonas could be predictive markers for rapid progression of mild cognitive impairment","title_match":true,"year":2023},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/potential-utility-of-plasma-p-tau-and-neurofilament-light-chain-as-36878697","doi":"10.1212/wnl.0000000000207115","journal":"Neurology","n_participants":257,"pmid":"36878697","source_url":"https://pubmed.ncbi.nlm.nih.gov/36878697/","study_design":"longitudinal study","title":"Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/sex-differences-in-risk-factors-that-predict-progression-from-mild-35968841","doi":"10.1017/s1355617722000297","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":449,"pmid":"35968841","source_url":"https://pubmed.ncbi.nlm.nih.gov/35968841/","study_design":null,"title":"Sex differences in risk factors that predict progression from mild cognitive impairment to Alzheimer's dementia","title_match":true,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/systematic-evaluation-of-urinary-formic-acid-as-a-new-potential-36533170","doi":"10.3389/fnagi.2022.1046066","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"36533170","source_url":"https://pubmed.ncbi.nlm.nih.gov/36533170/","study_design":null,"title":"Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau181-levels-reflect-white-matter-35015198","doi":"10.1007/s11011-022-00908-7","journal":"Metabolic brain disease","n_participants":41,"pmid":"35015198","source_url":"https://pubmed.ncbi.nlm.nih.gov/35015198/","study_design":"prospective cohort","title":"Plasma phosphorylated-tau181 levels reflect white matter microstructural changes across Alzheimer's disease progression","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/role-of-cerebrospinal-fluid-biomarkers-to-predict-conversion-to-25274948","doi":"10.1515/cclm-2014-0414","journal":"Clinical chemistry and laboratory medicine","n_participants":null,"pmid":"25274948","source_url":"https://pubmed.ncbi.nlm.nih.gov/25274948/","study_design":null,"title":"Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study","title_match":true,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/proteomics-determined-differences-in-the-concanavalin-a-fractionated-19072283","doi":"10.1021/pr800667a","journal":"Journal of proteome research","n_participants":null,"pmid":"19072283","source_url":"https://pubmed.ncbi.nlm.nih.gov/19072283/","study_design":null,"title":"Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD","title_match":true,"year":2009},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/evaluation-of-inner-retinal-layers-as-biomarkers-in-mild-cognitive-29420642","doi":"10.1371/journal.pone.0192646","journal":"PloS one","n_participants":15,"pmid":"29420642","source_url":"https://pubmed.ncbi.nlm.nih.gov/29420642/","study_design":"case-control study","title":"Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-gfap-in-parkinson-s-disease-with-cognitive-impairment-and-its-36759508","doi":"10.1038/s41531-023-00447-7","journal":"NPJ Parkinson's disease","n_participants":31,"pmid":"36759508","source_url":"https://pubmed.ncbi.nlm.nih.gov/36759508/","study_design":null,"title":"Plasma GFAP in Parkinson's disease with cognitive impairment and its potential to predict conversion to dementia","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-4-specific-imbalance-of-arachidonic-acid-and-docosahexaenoic-28333036","doi":"10.18632/aging.101203","journal":"Aging","n_participants":null,"pmid":"28333036","source_url":"https://pubmed.ncbi.nlm.nih.gov/28333036/","study_design":null,"title":"APOE \u03b54 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/evolution-of-abeta42-and-abeta40-levels-and-abeta42-abeta40-ratio-in-19262954","doi":"10.1007/s12603-009-0059-0","journal":"The journal of nutrition, health & aging","n_participants":null,"pmid":"19262954","source_url":"https://pubmed.ncbi.nlm.nih.gov/19262954/","study_design":"cross-sectional","title":"Evolution of Abeta42 and Abeta40 levels and Abeta42/Abeta40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment","title_match":false,"year":2009},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/optimal-combinations-of-csf-biomarkers-for-predicting-cognitive-36648169","doi":"10.1002/alz.12907","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1983,"pmid":"36648169","source_url":"https://pubmed.ncbi.nlm.nih.gov/36648169/","study_design":"longitudinal study","title":"Optimal combinations of CSF biomarkers for predicting cognitive decline and clinical conversion in cognitively unimpaired participants and mild cognitive impairment patients: A multi-cohort study","title_match":true,"year":2023},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/clinical-performance-of-an-antibody-free-assay-for-plasma-a42-a40-to-36604729","doi":"10.1186/s13195-022-01143-z","journal":"Alzheimer's research & therapy","n_participants":200,"pmid":"36604729","source_url":"https://pubmed.ncbi.nlm.nih.gov/36604729/","study_design":"cohort study","title":"Clinical performance of an antibody-free assay for plasma A\u03b242/A\u03b240 to detect early alterations of Alzheimer's disease in individuals with subjective cognitive decline","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/diagnostic-utility-of-selected-serum-dementia-biomarkers-amyloid-40-33121040","doi":"10.3390/jcm9113452","journal":"Journal of clinical medicine","n_participants":null,"pmid":"33121040","source_url":"https://pubmed.ncbi.nlm.nih.gov/33121040/","study_design":"cross-sectional","title":"Diagnostic Utility of Selected Serum Dementia Biomarkers: Amyloid \u03b2-40, Amyloid \u03b2-42, Tau Protein, and YKL-40: A Review","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-contribution-of-vascular-risk-factors-in-neurodegenerative-32753051","doi":"10.1186/s13195-020-00658-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"32753051","source_url":"https://pubmed.ncbi.nlm.nih.gov/32753051/","study_design":"cross-sectional","title":"The contribution of vascular risk factors in neurodegenerative disorders: from mild cognitive impairment to Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-relationship-of-plasma-a-levels-to-dementia-in-aging-individuals-21440911","doi":"10.1016/j.jns.2011.03.005","journal":"Journal of the neurological sciences","n_participants":588,"pmid":"21440911","source_url":"https://pubmed.ncbi.nlm.nih.gov/21440911/","study_design":null,"title":"The relationship of plasma A\u03b2 levels to dementia in aging individuals with mild cognitive impairment","title_match":false,"year":2011},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/correlation-between-brain-structure-atrophy-and-plasma-amyloid-and-35547625","doi":"10.3389/fnagi.2022.816043","journal":"Frontiers in aging neuroscience","n_participants":33,"pmid":"35547625","source_url":"https://pubmed.ncbi.nlm.nih.gov/35547625/","study_design":null,"title":"Correlation Between Brain Structure Atrophy and Plasma Amyloid-\u03b2 and Phosphorylated Tau in Patients With Alzheimer's Disease and Amnestic Mild Cognitive Impairment Explored by Surface-Based Morphometry","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-a42-as-a-biomarker-of-prodromal-alzheimer-s-disease-30149449","doi":"10.3233/jad-180321","journal":"Journal of Alzheimer's disease : JAD","n_participants":76,"pmid":"30149449","source_url":"https://pubmed.ncbi.nlm.nih.gov/30149449/","study_design":"longitudinal study","title":"Plasma A\u03b242 as a Biomarker of Prodromal Alzheimer's Disease Progression in Patients with Amnestic Mild Cognitive Impairment: Evidence from the PharmaCog/E-ADNI Study","title_match":true,"year":2019},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/risk-of-conversion-to-mild-cognitive-impairment-or-dementia-among-38610055","doi":"10.1186/s13195-024-01455-2","journal":"Alzheimer's research & therapy","n_participants":7793,"pmid":"38610055","source_url":"https://pubmed.ncbi.nlm.nih.gov/38610055/","study_design":"systematic review","title":"Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis","title_match":true,"year":2024},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/alzheimer-s-cerebrospinal-biomarkers-from-lumipulse-fully-automated-33436035","doi":"10.1186/s13195-020-00767-3","journal":"Alzheimer's research & therapy","n_participants":128,"pmid":"33436035","source_url":"https://pubmed.ncbi.nlm.nih.gov/33436035/","study_design":"longitudinal study","title":"Alzheimer's cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans : CSF AD biomarkers measured by Lumipulse in Koreans","title_match":false,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/erlangen-score-as-a-tool-to-predict-progression-from-mild-cognitive-30611311","doi":"10.1186/s13195-018-0456-x","journal":"Alzheimer's research & therapy","n_participants":47,"pmid":"30611311","source_url":"https://pubmed.ncbi.nlm.nih.gov/30611311/","study_design":null,"title":"Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/combination-of-plasma-tumor-necrosis-factor-receptors-signaling-23500026","doi":"10.1016/j.neulet.2013.03.007","journal":"Neuroscience letters","n_participants":153,"pmid":"23500026","source_url":"https://pubmed.ncbi.nlm.nih.gov/23500026/","study_design":null,"title":"Combination of plasma tumor necrosis factor receptors signaling proteins, beta-amyloid and apolipoprotein E for the detection of Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/identification-of-circulating-risk-biomarkers-for-cognitive-decline-39713874","doi":"10.1002/alz.14443","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":26554,"pmid":"39713874","source_url":"https://pubmed.ncbi.nlm.nih.gov/39713874/","study_design":"cohort study","title":"Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China","title_match":false,"year":2025},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/predicting-longitudinal-cognitive-decline-and-alzheimer-s-conversion-38994939","doi":"10.3390/cells13131085","journal":"Cells","n_participants":50,"pmid":"38994939","source_url":"https://pubmed.ncbi.nlm.nih.gov/38994939/","study_design":"cohort study","title":"Predicting Longitudinal Cognitive Decline and Alzheimer's Conversion in Mild Cognitive Impairment Patients Based on Plasma Biomarkers","title_match":true,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/the-hippocampal-subfield-volume-reduction-and-plasma-biomarker-38489180","doi":"10.3233/jad-231114","journal":"Journal of Alzheimer's disease : JAD","n_participants":40,"pmid":"38489180","source_url":"https://pubmed.ncbi.nlm.nih.gov/38489180/","study_design":"cross-sectional","title":"The Hippocampal Subfield Volume Reduction and Plasma Biomarker Changes in Mild Cognitive Impairment and Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/elevated-plasma-a42-in-cognitively-impaired-individuals-taking-ace-28449585","doi":"10.1177/1533317517707288","journal":"American journal of Alzheimer's disease and other dementias","n_participants":null,"pmid":"28449585","source_url":"https://pubmed.ncbi.nlm.nih.gov/28449585/","study_design":null,"title":"Elevated Plasma A\u03b242 in Cognitively Impaired Individuals Taking ACE Inhibitor Antihypertensives","title_match":false,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/exploring-the-potential-of-fully-automated-lumipulse-g-plasma-assays-38454502","doi":"10.1186/s13195-024-01397-9","journal":"Alzheimer's research & therapy","n_participants":138,"pmid":"38454502","source_url":"https://pubmed.ncbi.nlm.nih.gov/38454502/","study_design":null,"title":"Exploring the potential of fully automated LUMIPULSE G plasma assays for detecting Alzheimer's disease pathology","title_match":false,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/biomarkers-of-inflammation-and-amyloid-beta-phagocytosis-in-patients-19699791","doi":"10.1016/j.exger.2009.08.003","journal":"Experimental gerontology","n_participants":null,"pmid":"19699791","source_url":"https://pubmed.ncbi.nlm.nih.gov/19699791/","study_design":null,"title":"Biomarkers of inflammation and amyloid-beta phagocytosis in patients at risk of Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-alzheimer-s-disease-much-promise-cautious-27738910","doi":"10.1007/s40291-016-0241-0","journal":"Molecular diagnosis & therapy","n_participants":null,"pmid":"27738910","source_url":"https://pubmed.ncbi.nlm.nih.gov/27738910/","study_design":"longitudinal study","title":"Blood Biomarkers for Alzheimer's Disease: Much Promise, Cautious Progress","title_match":false,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-blood-based-multi-pathway-biomarker-assay-for-early-detection-and-38183344","doi":"10.1002/alz.13676","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38183344","source_url":"https://pubmed.ncbi.nlm.nih.gov/38183344/","study_design":null,"title":"A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/predicting-alzheimer-disease-from-a-blood-based-biomarker-profile-a-27534714","doi":"10.1212/wnl.0000000000003094","journal":"Neurology","n_participants":74,"pmid":"27534714","source_url":"https://pubmed.ncbi.nlm.nih.gov/27534714/","study_design":null,"title":"Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up","title_match":false,"year":2016},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/longitudinal-data-in-peripheral-blood-confirm-that-pm20d1-is-a-33298155","doi":"10.1186/s13148-020-00984-5","journal":"Clinical epigenetics","n_participants":649,"pmid":"33298155","source_url":"https://pubmed.ncbi.nlm.nih.gov/33298155/","study_design":"longitudinal study","title":"Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer's disease and implicate its dynamic role in disease progression","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-based-oligomeric-and-other-protein-variant-biomarkers-to-28372328","doi":"10.3233/jad-161116","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28372328","source_url":"https://pubmed.ncbi.nlm.nih.gov/28372328/","study_design":"longitudinal study","title":"Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/efficacy-and-safety-of-kami-guibi-tang-for-mild-cognitive-impairment-34620151","doi":"10.1186/s12906-021-03428-6","journal":"BMC complementary medicine and therapies","n_participants":16,"pmid":"34620151","source_url":"https://pubmed.ncbi.nlm.nih.gov/34620151/","study_design":null,"title":"Efficacy and safety of Kami-guibi-tang for mild cognitive impairment: a pilot, randomized, double-blind, placebo-controlled trial","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/harmonisation-a-multimodal-prospective-study-of-vascular-cognitive-41160443","doi":"10.1177/13872877251389006","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"41160443","source_url":"https://pubmed.ncbi.nlm.nih.gov/41160443/","study_design":null,"title":"HARMONISATION - A multimodal prospective study of vascular cognitive impairment in multi-ethnic Asians: Cohort profile, progress, current contributions, and future impact","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/identification-of-plasma-proteins-as-biomarkers-for-mild-cognitive-37685872","doi":"10.3390/ijms241713064","journal":"International journal of molecular sciences","n_participants":192,"pmid":"37685872","source_url":"https://pubmed.ncbi.nlm.nih.gov/37685872/","study_design":null,"title":"Identification of Plasma Proteins as Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease Using Liquid Chromatography-Tandem Mass Spectrometry","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/machine-learning-based-classification-of-subjective-cognitive-decline-36378559","doi":"10.1021/acschemneuro.2c00255","journal":"ACS chemical neuroscience","n_participants":206,"pmid":"36378559","source_url":"https://pubmed.ncbi.nlm.nih.gov/36378559/","study_design":null,"title":"Machine Learning-Based Classification of Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Dementia Using Neuroimage and Plasma Biomarkers","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/circulatory-gsk-3-blood-based-biomarker-and-therapeutic-target-for-34776454","doi":"10.3233/jad-215347","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34776454","source_url":"https://pubmed.ncbi.nlm.nih.gov/34776454/","study_design":null,"title":"Circulatory GSK-3\u03b2: Blood-Based Biomarker and Therapeutic Target for Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/predictive-utility-of-plasma-amyloid-and-tau-for-cognitive-decline-in-36946444","doi":"10.14283/jpad.2023.15","journal":"The journal of prevention of Alzheimer's disease","n_participants":60,"pmid":"36946444","source_url":"https://pubmed.ncbi.nlm.nih.gov/36946444/","study_design":"longitudinal study","title":"Predictive Utility of Plasma Amyloid and Tau for Cognitive Decline in Cognitively Normal Adults","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/homocysteine-a-predictor-for-five-year-mortality-in-patients-with-36509298","doi":"10.1016/j.exger.2022.112045","journal":"Experimental gerontology","n_participants":null,"pmid":"36509298","source_url":"https://pubmed.ncbi.nlm.nih.gov/36509298/","study_design":null,"title":"Homocysteine - A predictor for five year-mortality in patients with subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/platelet-membrane-secretase-activity-in-mild-cognitive-impairment-and-26639974","doi":"10.3233/jad-150795","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26639974","source_url":"https://pubmed.ncbi.nlm.nih.gov/26639974/","study_design":"longitudinal study","title":"Platelet Membrane \u03b2-Secretase Activity in Mild Cognitive Impairment and Conversion to Dementia: a Longitudinal Study","title_match":true,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/health-economic-considerations-in-the-deployment-of-an-alzheimer-s-38374736","doi":"10.14283/jpad.2024.23","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"38374736","source_url":"https://pubmed.ncbi.nlm.nih.gov/38374736/","study_design":null,"title":"Health Economic Considerations in the Deployment of an Alzheimer's Prevention Therapy","title_match":false,"year":2024},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/association-between-cell-bound-blood-amyloid-1-40-levels-and-25484928","doi":"10.1186/s13195-014-0056-3","journal":"Alzheimer's research & therapy","n_participants":96,"pmid":"25484928","source_url":"https://pubmed.ncbi.nlm.nih.gov/25484928/","study_design":"meta-analysis","title":"Association between cell-bound blood amyloid-\u03b2(1-40) levels and hippocampus volume","title_match":false,"year":2014},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/parkinson-s-progression-markers-initiative-brain-autopsy-program-35803091","doi":"10.1016/j.parkreldis.2022.06.017","journal":"Parkinsonism & related disorders","n_participants":15,"pmid":"35803091","source_url":"https://pubmed.ncbi.nlm.nih.gov/35803091/","study_design":"longitudinal study","title":"Parkinson's Progression Markers Initiative brain autopsy program","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/prediction-of-conversion-from-mild-cognitive-impairment-to-alzheimer-21159408","doi":"10.1016/j.neurobiolaging.2010.10.019","journal":"Neurobiology of aging","n_participants":81,"pmid":"21159408","source_url":"https://pubmed.ncbi.nlm.nih.gov/21159408/","study_design":null,"title":"Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance","title_match":true,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/qualification-of-the-analytical-and-clinical-performance-of-csf-21311900","doi":"10.1007/s00401-011-0808-0","journal":"Acta neuropathologica","n_participants":null,"pmid":"21311900","source_url":"https://pubmed.ncbi.nlm.nih.gov/21311900/","study_design":null,"title":"Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI","title_match":false,"year":2011},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/value-of-csf-beta-amyloid1-42-and-tau-as-predictors-of-alzheimer-s-14699432","doi":"10.1038/sj.mp.4001473","journal":"Molecular psychiatry","n_participants":52,"pmid":"14699432","source_url":"https://pubmed.ncbi.nlm.nih.gov/14699432/","study_design":null,"title":"Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment","title_match":false,"year":2004},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/combining-mri-and-csf-measures-for-classification-of-alzheimer-s-22580170","doi":"10.1016/j.neuroimage.2012.04.056","journal":"NeuroImage","n_participants":369,"pmid":"22580170","source_url":"https://pubmed.ncbi.nlm.nih.gov/22580170/","study_design":null,"title":"Combining MRI and CSF measures for classification of Alzheimer's disease and prediction of mild cognitive impairment conversion","title_match":true,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/csf-tau-abeta42-ratio-for-increased-risk-of-mild-cognitive-impairment-17698783","doi":"10.1212/01.wnl.0000267428.62582.aa","journal":"Neurology","n_participants":12,"pmid":"17698783","source_url":"https://pubmed.ncbi.nlm.nih.gov/17698783/","study_design":null,"title":"CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study","title_match":false,"year":2007},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/predicting-cognitive-decline-in-subjects-at-risk-for-alzheimer-23232293","doi":"10.1148/radiol.12120010","journal":"Radiology","n_participants":97,"pmid":"23232293","source_url":"https://pubmed.ncbi.nlm.nih.gov/23232293/","study_design":null,"title":"Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/identification-of-conversion-from-mild-cognitive-impairment-to-21814561","doi":"10.1371/journal.pone.0021896","journal":"PloS one","n_participants":null,"pmid":"21814561","source_url":"https://pubmed.ncbi.nlm.nih.gov/21814561/","study_design":null,"title":"Identification of conversion from mild cognitive impairment to Alzheimer's disease using multivariate predictors","title_match":true,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/intelligent-digital-tools-for-screening-of-brain-connectivity-and-38250599","doi":"10.3389/fnbot.2023.1289406","journal":"Frontiers in neurorobotics","n_participants":null,"pmid":"38250599","source_url":"https://pubmed.ncbi.nlm.nih.gov/38250599/","study_design":null,"title":"Intelligent digital tools for screening of brain connectivity and dementia risk estimation in people affected by mild cognitive impairment: the AI-Mind clinical study protocol","title_match":false,"year":2023},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cognitive-training-and-neuroplasticity-in-mild-cognitive-impairment-31471436","doi":"10.1136/bmjopen-2018-028536","journal":"BMJ open","n_participants":100,"pmid":"31471436","source_url":"https://pubmed.ncbi.nlm.nih.gov/31471436/","study_design":null,"title":"Cognitive training and neuroplasticity in mild cognitive impairment (COG-IT): protocol for a two-site, blinded, randomised, controlled treatment trial","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/differential-effects-of-a-computerized-cognitive-stimulation-program-30214174","doi":"10.2147/cia.s152225","journal":"Clinical interventions in aging","n_participants":null,"pmid":"30214174","source_url":"https://pubmed.ncbi.nlm.nih.gov/30214174/","study_design":null,"title":"Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities","title_match":false,"year":2018},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/digital-biomarkers-and-sex-impacts-in-alzheimer-s-disease-management-35719134","doi":"10.1007/s13167-022-00284-3","journal":"The EPMA journal","n_participants":568,"pmid":"35719134","source_url":"https://pubmed.ncbi.nlm.nih.gov/35719134/","study_design":"longitudinal study","title":"Digital biomarkers and sex impacts in Alzheimer's disease management - potential utility for innovative 3P medicine approach","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-digital-teleneuropsychology-platform-for-the-diagnosis-of-mild-38378904","doi":"10.1007/s10072-024-07403-0","journal":"Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology","n_participants":null,"pmid":"38378904","source_url":"https://pubmed.ncbi.nlm.nih.gov/38378904/","study_design":null,"title":"A digital teleneuropsychology platform for the diagnosis of mild cognitive impairment: from concept to certification as a medical device","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/brain-health-indicators-following-acute-neuro-exergaming-biomarker-37371324","doi":"10.3390/brainsci13060844","journal":"Brain sciences","n_participants":null,"pmid":"37371324","source_url":"https://pubmed.ncbi.nlm.nih.gov/37371324/","study_design":null,"title":"Brain Health Indicators Following Acute Neuro-Exergaming: Biomarker and Cognition in Mild Cognitive Impairment (MCI) after Pedal-n-Play (iPACES)","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/shanghai-cognitive-intervention-of-mild-cognitive-impairment-for-30041656","doi":"10.1186/s12883-018-1100-x","journal":"BMC neurology","n_participants":800,"pmid":"30041656","source_url":"https://pubmed.ncbi.nlm.nih.gov/30041656/","study_design":null,"title":"Shanghai cognitive intervention of mild cognitive impairment for delaying progress with longitudinal evaluation-a prospective, randomized controlled study (SIMPLE): rationale, design, and methodology","title_match":true,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/neurotechnology-and-ai-approach-for-early-dementia-onset-biomarker-34892639","doi":"10.1109/embc46164.2021.9630736","journal":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","n_participants":null,"pmid":"34892639","source_url":"https://pubmed.ncbi.nlm.nih.gov/34892639/","study_design":null,"title":"Neurotechnology and AI Approach for Early Dementia Onset Biomarker from EEG in Emotional Stimulus Evaluation Task","title_match":false,"year":2021},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/tablet-based-sensorimotor-home-training-system-for-amnestic-mild-31377702","doi":"10.1136/bmjopen-2018-028632","journal":"BMJ open","n_participants":30,"pmid":"31377702","source_url":"https://pubmed.ncbi.nlm.nih.gov/31377702/","study_design":"randomized controlled trial","title":"Tablet-based sensorimotor home-training system for amnestic mild cognitive impairments in the elderly: design of a randomised clinical trial","title_match":false,"year":2019},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/effects-of-a-personalised-adapted-computerised-cognitive-stimulation-40326579","doi":"10.23938/assn.1118","journal":"Anales del sistema sanitario de Navarra","n_participants":null,"pmid":"40326579","source_url":"https://pubmed.ncbi.nlm.nih.gov/40326579/","study_design":"randomized controlled trial","title":"[Effects of a personalised, adapted computerised cognitive stimulation programme versus stimulating leisure activities in younger and older adults with mild or subjective cognitive impairment. Protocol for a randomised controlled trial]","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/development-of-a-digital-multidomain-lifestyle-intervention-for-mild-39430697","doi":"10.1177/20552076241284810","journal":"Digital health","n_participants":19,"pmid":"39430697","source_url":"https://pubmed.ncbi.nlm.nih.gov/39430697/","study_design":null,"title":"Development of a digital multidomain lifestyle intervention for mild cognitive impairment: A pilot study on the feasibility and efficacy of cognitive training","title_match":false,"year":2024},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/prediction-of-mild-cognitive-impairment-status-pilot-study-of-machine-39024003","doi":"10.2196/55575","journal":"JMIR formative research","n_participants":20,"pmid":"39024003","source_url":"https://pubmed.ncbi.nlm.nih.gov/39024003/","study_design":"longitudinal study","title":"Prediction of Mild Cognitive Impairment Status: Pilot Study of Machine Learning Models Based on Longitudinal Data From Fitness Trackers","title_match":false,"year":2024},{"alzhub_score":86,"alzhub_url":"https://alzhub.org/study/genome-wide-significant-risk-factors-for-alzheimer-s-disease-role-in-26976043","doi":"10.1038/mp.2016.18","journal":"Molecular psychiatry","n_participants":853,"pmid":"26976043","source_url":"https://pubmed.ncbi.nlm.nih.gov/26976043/","study_design":"meta-analysis","title":"Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment","title_match":true,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/higher-csf-stnfr1-related-proteins-associate-with-better-prognosis-in-34183654","doi":"10.1038/s41467-021-24220-7","journal":"Nature communications","n_participants":382,"pmid":"34183654","source_url":"https://pubmed.ncbi.nlm.nih.gov/34183654/","study_design":null,"title":"Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/synaptic-degeneration-in-alzheimer-s-disease-19390859","doi":"10.1007/s00401-009-0536-x","journal":"Acta neuropathologica","n_participants":null,"pmid":"19390859","source_url":"https://pubmed.ncbi.nlm.nih.gov/19390859/","study_design":null,"title":"Synaptic degeneration in Alzheimer's disease","title_match":false,"year":2009}]}
