{"data_date":"2026-11-13","library_size":31380,"matched_against":"each record's title and abstract (summary field), case-insensitive","n":1409,"page":"https://alzhub.org/answers/lewy-body-dementia-vs-alzheimers","query":"title or abstract mentions \"Lewy body/bodies\", \"DLB\" or \"alpha-synuclein\"","studies":[{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/safety-and-efficacy-of-pimavanserin-in-patients-with-lewy-body-41286676","doi":"10.1186/s12883-025-04496-8","journal":"BMC Neurology","n_participants":76,"pmid":"41286676","source_url":"https://pubmed.ncbi.nlm.nih.gov/41286676/","study_design":"phase-3-trial","title":"Safety and efficacy of pimavanserin in patients with Lewy body dementia experiencing dementia-related psychosis in the HARMONY study","title_match":true,"year":2025},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/incidence-and-prevalence-of-frontotemporal-dementia-a-systematic-40920400","doi":"10.1001/jamaneurol.2025.3307","journal":"JAMA Neurology","n_participants":null,"pmid":"40920400","source_url":"https://pubmed.ncbi.nlm.nih.gov/40920400/","study_design":"meta-analysis","title":"Incidence and Prevalence of Frontotemporal Dementia: A Systematic Review and Meta-Analysis","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-the-synuclein-seed-amplification-assay-for-41604609","doi":"10.1212/WNL.0000000000214614","journal":"Neurology","n_participants":30,"pmid":"41604609","source_url":"https://pubmed.ncbi.nlm.nih.gov/41604609/","study_design":"cross-sectional","title":"Diagnostic Performance of the \u03b1-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories","title_match":true,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/two-step-detection-of-lewy-body-pathology-via-smell-function-testing-40764485","doi":"10.1038/s41467-025-62458-7","journal":"Nature Communications","n_participants":1567,"pmid":"40764485","source_url":"https://pubmed.ncbi.nlm.nih.gov/40764485/","study_design":"cohort","title":"Two-step detection of Lewy body pathology via smell-function testing and CSF \u03b1-synuclein seed amplification","title_match":true,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/lewy-body-pathology-exacerbates-brain-hypometabolism-and-cognitive-39277604","doi":"10.1038/s41467-024-52299-1","journal":"Nature Communications","n_participants":795,"pmid":"39277604","source_url":"https://pubmed.ncbi.nlm.nih.gov/39277604/","study_design":"cohort","title":"Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/long-term-effects-of-cholinesterase-inhibitors-and-memantine-on-39177108","doi":"10.1002/alz.14118","journal":"Alzheimer's & Dementia","n_participants":1095,"pmid":"39177108","source_url":"https://pubmed.ncbi.nlm.nih.gov/39177108/","study_design":"cohort","title":"Long-term effects of cholinesterase inhibitors and memantine on cognitive decline, cardiovascular events, and mortality in dementia with Lewy bodies: An up to 10-year follow-up study","title_match":true,"year":2024},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/sleep-apnea-and-the-risk-of-dementia-a-systematic-review-and-meta-35366021","doi":"10.1111/jsr.13589","journal":"Journal of Sleep Research","n_participants":1333424,"pmid":"35366021","source_url":"https://pubmed.ncbi.nlm.nih.gov/35366021/","study_design":"meta-analysis","title":"Sleep apnea and the risk of dementia: A systematic review and meta-analysis","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-alzheimer-biomarkers-and-diagnostic-decision-making-in-memory-42593792","doi":"10.1001/jamanetworkopen.2026.28864","journal":"JAMA Network Open","n_participants":450,"pmid":"42593792","source_url":"https://pubmed.ncbi.nlm.nih.gov/42593792/","study_design":"cohort","title":"Plasma Alzheimer Biomarkers and Diagnostic Decision-Making in Memory Clinics","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-a42-40-ratio-p-tau181-gfap-and-nfl-40551285","doi":"10.1002/alz.14573","journal":"Alzheimer's & Dementia","n_participants":1298,"pmid":"40551285","source_url":"https://pubmed.ncbi.nlm.nih.gov/40551285/","study_design":"cross-sectional","title":"Diagnostic performance of plasma A\u03b242/40 ratio, p-tau181, GFAP, and NfL along the continuum of Alzheimer's disease and non-AD dementias: An international multi-center study","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neuropathologic-profiles-and-associated-cognitive-trajectories-in-41543852","doi":"10.1001/jamanetworkopen.2025.54354","journal":"JAMA Network Open","n_participants":1633,"pmid":"41543852","source_url":"https://pubmed.ncbi.nlm.nih.gov/41543852/","study_design":"cohort","title":"Neuropathologic Profiles and Associated Cognitive Trajectories in Community-Living Older Adults","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/systemic-complement-factors-in-aging-alzheimer-s-disease-and-other-41526986","doi":"10.1186/s13024-026-00927-3","journal":"Molecular Neurodegeneration","n_participants":558,"pmid":"41526986","source_url":"https://pubmed.ncbi.nlm.nih.gov/41526986/","study_design":"cohort","title":"Systemic complement factors in aging, Alzheimer's disease and other dementias: a longitudinal study over 10 years","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/altered-microrna-profiles-in-cerebrospinal-fluid-exosome-in-parkinson-26497684","doi":"10.18632/oncotarget.6158","journal":"Oncotarget","n_participants":null,"pmid":"26497684","source_url":"https://pubmed.ncbi.nlm.nih.gov/26497684/","study_design":null,"title":"Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease","title_match":false,"year":2015},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/accuracy-of-a-panel-of-5-cerebrospinal-fluid-biomarkers-in-the-22925882","doi":"10.1001/archneurol.2012.1654","journal":"Archives of neurology","n_participants":453,"pmid":"22925882","source_url":"https://pubmed.ncbi.nlm.nih.gov/22925882/","study_design":"cross-sectional","title":"Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders","title_match":false,"year":2012},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/csf-a42-a40-and-a42-a38-ratios-better-diagnostic-markers-of-alzheimer-27042676","doi":"10.1002/acn3.274","journal":"Annals of clinical and translational neurology","n_participants":1182,"pmid":"27042676","source_url":"https://pubmed.ncbi.nlm.nih.gov/27042676/","study_design":null,"title":"CSF A\u03b242/A\u03b240 and A\u03b242/A\u03b238 ratios: better diagnostic markers of Alzheimer disease","title_match":false,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/brain-pet-in-the-diagnosis-of-alzheimer-s-disease-25199063","doi":"10.1097/rlu.0000000000000547","journal":"Clinical nuclear medicine","n_participants":null,"pmid":"25199063","source_url":"https://pubmed.ncbi.nlm.nih.gov/25199063/","study_design":null,"title":"Brain PET in the diagnosis of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-cerebrospinal-fluid-neurofilament-light-protein-levels-30508027","doi":"10.1001/jamaneurol.2018.3746","journal":"JAMA neurology","n_participants":913,"pmid":"30508027","source_url":"https://pubmed.ncbi.nlm.nih.gov/30508027/","study_design":"case-control study","title":"Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders","title_match":false,"year":2019},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-plasma-p-tau181-nfl-and-gfap-in-a-clinical-36221099","doi":"10.1186/s13195-022-01093-6","journal":"Alzheimer's research & therapy","n_participants":59,"pmid":"36221099","source_url":"https://pubmed.ncbi.nlm.nih.gov/36221099/","study_design":null,"title":"Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/amyloid-pet-imaging-in-lewy-body-disorders-23831180","doi":"10.1016/j.jagp.2013.03.001","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"23831180","source_url":"https://pubmed.ncbi.nlm.nih.gov/23831180/","study_design":"longitudinal study","title":"Amyloid PET Imaging in Lewy body disorders","title_match":true,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/clinical-and-imaging-features-of-mixed-alzheimer-and-vascular-25722748","doi":"10.1186/s13195-015-0104-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"25722748","source_url":"https://pubmed.ncbi.nlm.nih.gov/25722748/","study_design":null,"title":"Clinical and imaging features of mixed Alzheimer and vascular pathologies","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/amyloid-pet-and-neuropathology-in-dementia-with-lewy-bodies-31862783","doi":"10.1212/wnl.0000000000008818","journal":"Neurology","n_participants":39,"pmid":"31862783","source_url":"https://pubmed.ncbi.nlm.nih.gov/31862783/","study_design":null,"title":"\u03b2-Amyloid PET and neuropathology in dementia with Lewy bodies","title_match":true,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/differential-levels-of-neurofilament-light-protein-in-cerebrospinal-32514050","doi":"10.1038/s41598-020-66090-x","journal":"Scientific reports","n_participants":535,"pmid":"32514050","source_url":"https://pubmed.ncbi.nlm.nih.gov/32514050/","study_design":null,"title":"Differential levels of Neurofilament Light protein in cerebrospinal fluid in patients with a wide range of neurodegenerative disorders","title_match":false,"year":2020},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/pet-approaches-for-diagnosis-of-dementia-23945233","doi":"10.3174/ajnr.a3695","journal":"AJNR. American journal of neuroradiology","n_participants":null,"pmid":"23945233","source_url":"https://pubmed.ncbi.nlm.nih.gov/23945233/","study_design":null,"title":"PET approaches for diagnosis of dementia","title_match":false,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/fas-antigen-expression-in-brains-of-patients-with-alzheimer-type-8556323","doi":"10.1016/0006-8993(95)00699-q","journal":"Brain research","n_participants":null,"pmid":"8556323","source_url":"https://pubmed.ncbi.nlm.nih.gov/8556323/","study_design":null,"title":"Fas antigen expression in brains of patients with Alzheimer-type dementia","title_match":false,"year":1995},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/salivary-biomarkers-for-alzheimer-s-disease-and-related-disorders-31833026","doi":"10.1007/s40120-019-00168-1","journal":"Neurology and therapy","n_participants":null,"pmid":"31833026","source_url":"https://pubmed.ncbi.nlm.nih.gov/31833026/","study_design":null,"title":"Salivary Biomarkers for Alzheimer's Disease and Related Disorders","title_match":false,"year":2019},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/n-myc-and-c-myc-expression-in-alzheimer-disease-huntington-disease-10837922","doi":"10.1016/s0169-328x(00)00062-0","journal":"Brain research. Molecular brain research","n_participants":null,"pmid":"10837922","source_url":"https://pubmed.ncbi.nlm.nih.gov/10837922/","study_design":null,"title":"N-myc and c-myc expression in Alzheimer disease, Huntington disease and Parkinson disease","title_match":false,"year":2000},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-association-of-alzheimer-pathology-with-34114602","doi":"10.1093/brain/awab218","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"34114602","source_url":"https://pubmed.ncbi.nlm.nih.gov/34114602/","study_design":null,"title":"Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks","title_match":true,"year":2021},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/glutamate-transporter-glt1-expression-in-alzheimer-disease-and-29755340","doi":"10.3389/fnagi.2018.00122","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"29755340","source_url":"https://pubmed.ncbi.nlm.nih.gov/29755340/","study_design":null,"title":"Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies","title_match":true,"year":2018},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-plasma-amyloid-p-tau-gfap-and-nfl-with-csf-clinical-38830138","doi":"10.1212/wnl.0000000000209418","journal":"Neurology","n_participants":89,"pmid":"38830138","source_url":"https://pubmed.ncbi.nlm.nih.gov/38830138/","study_design":"cohort study","title":"Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies","title_match":true,"year":2024},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/investigation-of-tau-2-positive-microglia-like-cells-in-the-7566636","doi":"10.1016/0304-3940(95)11595-n","journal":"Neuroscience letters","n_participants":null,"pmid":"7566636","source_url":"https://pubmed.ncbi.nlm.nih.gov/7566636/","study_design":null,"title":"Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders","title_match":false,"year":1995},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/csf-synaptic-biomarkers-in-at-n-based-subgroups-of-lewy-body-disease-37188538","doi":"10.1212/wnl.0000000000207371","journal":"Neurology","n_participants":101,"pmid":"37188538","source_url":"https://pubmed.ncbi.nlm.nih.gov/37188538/","study_design":null,"title":"CSF Synaptic Biomarkers in AT(N)-Based Subgroups of Lewy Body Disease","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/potential-diagnostic-value-of-red-blood-cells-synuclein-30826968","doi":"10.1007/s12035-019-1531-4","journal":"Molecular neurobiology","n_participants":39,"pmid":"30826968","source_url":"https://pubmed.ncbi.nlm.nih.gov/30826968/","study_design":null,"title":"Potential Diagnostic Value of Red Blood Cells \u03b1-Synuclein Heteroaggregates in Alzheimer's Disease","title_match":true,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/csf-p-tau181-and-other-biomarkers-in-patients-with-neuronal-36517236","doi":"10.1212/wnl.0000000000201647","journal":"Neurology","n_participants":12,"pmid":"36517236","source_url":"https://pubmed.ncbi.nlm.nih.gov/36517236/","study_design":null,"title":"CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-pet-in-dementia-syndromes-a-chinese-multicenter-study-32385166","doi":"10.2967/jnumed.119.240325","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":null,"pmid":"32385166","source_url":"https://pubmed.ncbi.nlm.nih.gov/32385166/","study_design":null,"title":"Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study","title_match":false,"year":2020},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/csf-synuclein-seed-amplification-assay-in-patients-with-atypical-39208367","doi":"10.1212/wnl.0000000000209818","journal":"Neurology","n_participants":50,"pmid":"39208367","source_url":"https://pubmed.ncbi.nlm.nih.gov/39208367/","study_design":"cross-sectional","title":"CSF \u03b1-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorders","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/in-vivo-assessment-of-lewy-body-and-beta-amyloid-copathologies-in-36071460","doi":"10.1186/s12987-022-00368-2","journal":"Fluids and barriers of the CNS","n_participants":null,"pmid":"36071460","source_url":"https://pubmed.ncbi.nlm.nih.gov/36071460/","study_design":null,"title":"In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome","title_match":true,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/multimodal-pet-imaging-of-amyloid-and-tau-pathology-in-alzheimer-28576172","doi":"10.1016/j.cpet.2017.02.005","journal":"PET clinics","n_participants":null,"pmid":"28576172","source_url":"https://pubmed.ncbi.nlm.nih.gov/28576172/","study_design":null,"title":"Multimodal PET Imaging of Amyloid and Tau Pathology in Alzheimer Disease and Non-Alzheimer Disease Dementias","title_match":false,"year":2017},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/amyloid-pet-ligands-for-dementia-27157482","doi":"10.1016/j.cpet.2009.12.008","journal":"PET clinics","n_participants":null,"pmid":"27157482","source_url":"https://pubmed.ncbi.nlm.nih.gov/27157482/","study_design":null,"title":"Amyloid PET Ligands for Dementia","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/predicting-regional-pattern-of-longitudinal-amyloid-accumulation-by-27754901","doi":"10.2967/jnumed.116.176115","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":58,"pmid":"27754901","source_url":"https://pubmed.ncbi.nlm.nih.gov/27754901/","study_design":"longitudinal study","title":"Predicting Regional Pattern of Longitudinal \u03b2-Amyloid Accumulation by Baseline PET","title_match":false,"year":2017},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/imaging-amyloidopathy-in-parkinson-disease-and-parkinsonian-dementia-25745616","doi":"10.1007/s40336-015-0104-4","journal":"Clinical and translational imaging","n_participants":null,"pmid":"25745616","source_url":"https://pubmed.ncbi.nlm.nih.gov/25745616/","study_design":null,"title":"Imaging Amyloidopathy in Parkinson Disease and Parkinsonian Dementia Syndromes","title_match":false,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acid-protein-and-phosphorated-tau-181-39560478","doi":"10.1148/radiol.233019","journal":"Radiology","n_participants":50,"pmid":"39560478","source_url":"https://pubmed.ncbi.nlm.nih.gov/39560478/","study_design":null,"title":"Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging","title_match":false,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/added-value-of-cerebrospinal-fluid-multimarker-analysis-in-diagnosis-33236496","doi":"10.1111/ene.14658","journal":"European journal of neurology","n_participants":319,"pmid":"33236496","source_url":"https://pubmed.ncbi.nlm.nih.gov/33236496/","study_design":"longitudinal study","title":"Added value of cerebrospinal fluid multimarker analysis in diagnosis and progression of dementia","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/dementia-in-parkinson-s-disease-correlates-with-synuclein-pathology-22577599","doi":"10.1155/2012/420957","journal":"Parkinson's disease","n_participants":null,"pmid":"22577599","source_url":"https://pubmed.ncbi.nlm.nih.gov/22577599/","study_design":null,"title":"Dementia in Parkinson's Disease Correlates with \u03b1-Synuclein Pathology but Not with Cortical Astrogliosis","title_match":true,"year":2012},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/high-sensitivity-plasma-proteomics-reveals-disease-specific-41250190","doi":"10.1186/s13024-025-00909-x","journal":"Molecular neurodegeneration","n_participants":3232,"pmid":"41250190","source_url":"https://pubmed.ncbi.nlm.nih.gov/41250190/","study_design":null,"title":"High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer's disease phenotypes in a large mixed-dementia cohort","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/molecular-imaging-of-alzheimer-disease-pathology-24503555","doi":"10.3174/ajnr.a3847","journal":"AJNR. American journal of neuroradiology","n_participants":null,"pmid":"24503555","source_url":"https://pubmed.ncbi.nlm.nih.gov/24503555/","study_design":"cohort study","title":"Molecular imaging of Alzheimer disease pathology","title_match":false,"year":2014},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/klotho-kl-vs-heterozygosity-is-associated-with-diminished-age-related-39030746","doi":"10.1002/alz.13912","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":122,"pmid":"39030746","source_url":"https://pubmed.ncbi.nlm.nih.gov/39030746/","study_design":null,"title":"KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults","title_match":false,"year":2024},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/neuroimaging-of-diseases-causing-dementia-31761062","doi":"10.1016/j.ncl.2019.08.003","journal":"Neurologic clinics","n_participants":null,"pmid":"31761062","source_url":"https://pubmed.ncbi.nlm.nih.gov/31761062/","study_design":null,"title":"Neuroimaging of Diseases Causing Dementia","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/plasma-tau-biomarkers-are-distinctly-associated-with-tau-tangles-and-40791093","doi":"10.1002/alz.70562","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40791093","source_url":"https://pubmed.ncbi.nlm.nih.gov/40791093/","study_design":null,"title":"Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/imaging-beta-amyloid-burden-in-aging-and-dementia-17502554","doi":"10.1212/01.wnl.0000261919.22630.ea","journal":"Neurology","n_participants":null,"pmid":"17502554","source_url":"https://pubmed.ncbi.nlm.nih.gov/17502554/","study_design":"longitudinal study","title":"Imaging beta-amyloid burden in aging and dementia","title_match":false,"year":2007},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/evaluation-of-csf-tau-and-csf-abeta42-as-diagnostic-markers-for-11255440","doi":"10.1001/archneur.58.3.373","journal":"Archives of neurology","n_participants":105,"pmid":"11255440","source_url":"https://pubmed.ncbi.nlm.nih.gov/11255440/","study_design":null,"title":"Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice","title_match":false,"year":2001},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/apoe-4-increases-risk-for-dementia-in-pure-synucleinopathies-23407718","doi":"10.1001/jamaneurol.2013.600","journal":"JAMA neurology","n_participants":244,"pmid":"23407718","source_url":"https://pubmed.ncbi.nlm.nih.gov/23407718/","study_design":"case-control study","title":"APOE \u03b54 increases risk for dementia in pure synucleinopathies","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-and-parkinson-s-disease-dementia-current-29222591","doi":"10.1007/s00702-017-1821-9","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"29222591","source_url":"https://pubmed.ncbi.nlm.nih.gov/29222591/","study_design":null,"title":"Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies","title_match":true,"year":2018},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/lt-i-gt-apoe-lt-i-gt-4-is-associated-with-severity-of-lewy-body-30143564","doi":"10.1212/wnl.0000000000006212","journal":"Neurology","n_participants":null,"pmid":"30143564","source_url":"https://pubmed.ncbi.nlm.nih.gov/30143564/","study_design":"case-control study","title":"APOE \u03b54 is associated with severity of Lewy body pathology independent of Alzheimer pathology","title_match":true,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/prevalence-and-impact-of-vascular-and-alzheimer-pathologies-in-lewy-18273624","doi":"10.1007/s00401-008-0347-5","journal":"Acta neuropathologica","n_participants":100,"pmid":"18273624","source_url":"https://pubmed.ncbi.nlm.nih.gov/18273624/","study_design":null,"title":"Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease","title_match":true,"year":2008},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/survival-and-mortality-differences-between-dementia-with-lewy-bodies-17159097","doi":"10.1212/01.wnl.0000247041.63081.98","journal":"Neurology","n_participants":315,"pmid":"17159097","source_url":"https://pubmed.ncbi.nlm.nih.gov/17159097/","study_design":"longitudinal study","title":"Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease","title_match":true,"year":2006},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/confluence-of-synuclein-tau-and-amyloid-pathologies-in-dementia-with-24226269","doi":"10.1097/nen.0000000000000018","journal":"Journal of neuropathology and experimental neurology","n_participants":22,"pmid":"24226269","source_url":"https://pubmed.ncbi.nlm.nih.gov/24226269/","study_design":null,"title":"Confluence of \u03b1-synuclein, tau, and \u03b2-amyloid pathologies in dementia with Lewy bodies","title_match":true,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/risk-factors-for-dementia-with-lewy-bodies-a-case-control-study-23892702","doi":"10.1212/wnl.0b013e3182a2cbd1","journal":"Neurology","n_participants":147,"pmid":"23892702","source_url":"https://pubmed.ncbi.nlm.nih.gov/23892702/","study_design":null,"title":"Risk factors for dementia with Lewy bodies: a case-control study","title_match":true,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-biomarkers-and-clinical-phenotype-in-dementia-with-32989106","doi":"10.1212/wnl.0000000000010943","journal":"Neurology","n_participants":417,"pmid":"32989106","source_url":"https://pubmed.ncbi.nlm.nih.gov/32989106/","study_design":null,"title":"\u03b2-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies","title_match":true,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/clinical-features-and-apoe-genotype-of-pathologically-proven-early-21576687","doi":"10.1212/wnl.0b013e31821a44dd","journal":"Neurology","n_participants":37,"pmid":"21576687","source_url":"https://pubmed.ncbi.nlm.nih.gov/21576687/","study_design":null,"title":"Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/clinical-features-of-alzheimer-disease-with-and-without-lewy-bodies-25985321","doi":"10.1001/jamaneurol.2015.0606","journal":"JAMA neurology","n_participants":null,"pmid":"25985321","source_url":"https://pubmed.ncbi.nlm.nih.gov/25985321/","study_design":"cohort study","title":"Clinical Features of Alzheimer Disease With and Without Lewy Bodies","title_match":true,"year":2015},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/lrp10-genetic-variants-in-familial-parkinson-s-disease-and-dementia-29887161","doi":"10.1016/s1474-4422(18)30179-0","journal":"The Lancet. Neurology","n_participants":null,"pmid":"29887161","source_url":"https://pubmed.ncbi.nlm.nih.gov/29887161/","study_design":null,"title":"LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study","title_match":true,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/neuropathologic-basis-of-age-associated-brain-atrophy-23552688","doi":"10.1001/jamaneurol.2013.1957","journal":"JAMA neurology","n_participants":null,"pmid":"23552688","source_url":"https://pubmed.ncbi.nlm.nih.gov/23552688/","study_design":"longitudinal study","title":"Neuropathologic basis of age-associated brain atrophy","title_match":false,"year":2013},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/regional-overlap-of-pathologies-in-lewy-body-disorders-28395086","doi":"10.1093/jnen/nlx002","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"28395086","source_url":"https://pubmed.ncbi.nlm.nih.gov/28395086/","study_design":null,"title":"Regional Overlap of Pathologies in Lewy Body Disorders","title_match":true,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/aberrant-phosphorylation-of-alpha-synuclein-in-human-niemann-pick-15099022","doi":"10.1093/jnen/63.4.323","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"15099022","source_url":"https://pubmed.ncbi.nlm.nih.gov/15099022/","study_design":null,"title":"Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease","title_match":true,"year":2004},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/lewy-body-pathology-and-chronic-traumatic-encephalopathy-associated-30053297","doi":"10.1093/jnen/nly065","journal":"Journal of neuropathology and experimental neurology","n_participants":269,"pmid":"30053297","source_url":"https://pubmed.ncbi.nlm.nih.gov/30053297/","study_design":null,"title":"Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports","title_match":true,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/hippocampal-sclerosis-in-the-elderly-genetic-and-pathologic-findings-21346515","doi":"10.1097/wad.0b013e31820f8f50","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"21346515","source_url":"https://pubmed.ncbi.nlm.nih.gov/21346515/","study_design":null,"title":"Hippocampal sclerosis in the elderly: genetic and pathologic findings, some mimicking Alzheimer disease clinically","title_match":false,"year":2011},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/gene-expression-profiles-in-parkinson-disease-prefrontal-cortex-22761592","doi":"10.1371/journal.pgen.1002794","journal":"PLoS genetics","n_participants":null,"pmid":"22761592","source_url":"https://pubmed.ncbi.nlm.nih.gov/22761592/","study_design":"meta-analysis","title":"Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/fine-mapping-of-the-chromosome-12-late-onset-alzheimer-disease-locus-10712207","doi":"10.1086/302828","journal":"American journal of human genetics","n_participants":null,"pmid":"10712207","source_url":"https://pubmed.ncbi.nlm.nih.gov/10712207/","study_design":null,"title":"Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity","title_match":false,"year":2000},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/dementia-prevention-and-treatment-a-narrative-review-38436963","doi":"10.1001/jamainternmed.2023.8522","journal":"JAMA internal medicine","n_participants":null,"pmid":"38436963","source_url":"https://pubmed.ncbi.nlm.nih.gov/38436963/","study_design":null,"title":"Dementia Prevention and Treatment: A Narrative Review","title_match":false,"year":2024},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/quetiapine-for-agitation-or-psychosis-in-patients-with-dementia-and-17452579","doi":"10.1212/01.wnl.0000260060.60870.89","journal":"Neurology","n_participants":23,"pmid":"17452579","source_url":"https://pubmed.ncbi.nlm.nih.gov/17452579/","study_design":null,"title":"Quetiapine for agitation or psychosis in patients with dementia and parkinsonism","title_match":false,"year":2007},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/treating-neuropsychiatric-symptoms-in-dementia-with-lewy-bodies-a-20625270","doi":"10.1097/wad.0b013e3181e6a4d7","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"20625270","source_url":"https://pubmed.ncbi.nlm.nih.gov/20625270/","study_design":null,"title":"Treating neuropsychiatric symptoms in dementia with Lewy bodies: a randomized controlled-trial","title_match":true,"year":2010},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/association-of-plasma-phosphorylated-tau-with-the-response-to-37657939","doi":"10.1212/wnl.0000000000207755","journal":"Neurology","n_participants":45,"pmid":"37657939","source_url":"https://pubmed.ncbi.nlm.nih.gov/37657939/","study_design":null,"title":"Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies","title_match":true,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/effectiveness-of-a-modified-continuum-curriculum-for-medical-students-21220718","doi":"10.1212/wnl.0b013e318205d4fa","journal":"Neurology","n_participants":null,"pmid":"21220718","source_url":"https://pubmed.ncbi.nlm.nih.gov/21220718/","study_design":"longitudinal study","title":"Effectiveness of a modified Continuum curriculum for medical students: a randomized trial","title_match":false,"year":2011},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/incidence-and-prediction-of-falls-in-dementia-a-prospective-study-in-19436724","doi":"10.1371/journal.pone.0005521","journal":"PloS one","n_participants":179,"pmid":"19436724","source_url":"https://pubmed.ncbi.nlm.nih.gov/19436724/","study_design":null,"title":"Incidence and prediction of falls in dementia: a prospective study in older people","title_match":false,"year":2009},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/risk-factors-for-neurodegeneration-in-idiopathic-rapid-eye-movement-25767079","doi":"10.1002/ana.24385","journal":"Annals of neurology","n_participants":305,"pmid":"25767079","source_url":"https://pubmed.ncbi.nlm.nih.gov/25767079/","study_design":null,"title":"Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study","title_match":false,"year":2015},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/long-term-incidence-of-dementia-predictors-of-mortality-and-22171356","doi":"10.1093/brain/awr273","journal":"Brain : a journal of neurology","n_participants":355,"pmid":"22171356","source_url":"https://pubmed.ncbi.nlm.nih.gov/22171356/","study_design":"longitudinal study","title":"Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors","title_match":false,"year":2011},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/clinical-features-and-multidisciplinary-approaches-to-dementia-care-21655340","doi":"10.2147/jmdh.s17773","journal":"Journal of multidisciplinary healthcare","n_participants":null,"pmid":"21655340","source_url":"https://pubmed.ncbi.nlm.nih.gov/21655340/","study_design":null,"title":"Clinical features and multidisciplinary approaches to dementia care","title_match":false,"year":2011},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/epidemiology-of-alzheimer-s-disease-and-other-dementias-29790571","doi":"10.33588/rn.6611.2017519","journal":"Revista de neurologia","n_participants":null,"pmid":"29790571","source_url":"https://pubmed.ncbi.nlm.nih.gov/29790571/","study_design":null,"title":"[Epidemiology of Alzheimer's disease and other dementias]","title_match":false,"year":2018},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/diagnosis-and-management-of-dementia-with-lewy-bodies-third-report-of-16237129","doi":"10.1212/01.wnl.0000187889.17253.b1","journal":"Neurology","n_participants":null,"pmid":"16237129","source_url":"https://pubmed.ncbi.nlm.nih.gov/16237129/","study_design":null,"title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","title_match":true,"year":2005},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/diagnosis-and-management-of-dementia-with-lewy-bodies-fourth-28592453","doi":"10.1212/wnl.0000000000004058","journal":"Neurology","n_participants":null,"pmid":"28592453","source_url":"https://pubmed.ncbi.nlm.nih.gov/28592453/","study_design":null,"title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","title_match":true,"year":2017},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/the-neuropathological-diagnosis-of-alzheimer-s-disease-31375134","doi":"10.1186/s13024-019-0333-5","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31375134","source_url":"https://pubmed.ncbi.nlm.nih.gov/31375134/","study_design":null,"title":"The neuropathological diagnosis of Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/consensus-guidelines-for-the-clinical-and-pathologic-diagnosis-of-8909416","doi":"10.1212/wnl.47.5.1113","journal":"Neurology","n_participants":null,"pmid":"8909416","source_url":"https://pubmed.ncbi.nlm.nih.gov/8909416/","study_design":null,"title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop","title_match":true,"year":1996},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/clinical-diagnostic-criteria-for-dementia-associated-with-parkinson-s-17542011","doi":"10.1002/mds.21507","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"17542011","source_url":"https://pubmed.ncbi.nlm.nih.gov/17542011/","study_design":"systematic review","title":"Clinical diagnostic criteria for dementia associated with Parkinson's disease","title_match":false,"year":2007},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/reactive-microglia-are-positive-for-hla-dr-in-the-substantia-nigra-of-3399080","doi":"10.1212/wnl.38.8.1285","journal":"Neurology","n_participants":null,"pmid":"3399080","source_url":"https://pubmed.ncbi.nlm.nih.gov/3399080/","study_design":null,"title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains","title_match":false,"year":1988},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/the-spectrum-of-disease-in-chronic-traumatic-encephalopathy-23208308","doi":"10.1093/brain/aws307","journal":"Brain : a journal of neurology","n_participants":85,"pmid":"23208308","source_url":"https://pubmed.ncbi.nlm.nih.gov/23208308/","study_design":null,"title":"The spectrum of disease in chronic traumatic encephalopathy","title_match":false,"year":2013},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/mixed-brain-pathologies-account-for-most-dementia-cases-in-community-17568013","doi":"10.1212/01.wnl.0000271090.28148.24","journal":"Neurology","n_participants":80,"pmid":"17568013","source_url":"https://pubmed.ncbi.nlm.nih.gov/17568013/","study_design":"cohort study","title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","title_match":false,"year":2007},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-addenbrooke-s-cognitive-examination-revised-ace-r-a-brief-16977673","doi":"10.1002/gps.1610","journal":"International journal of geriatric psychiatry","n_participants":241,"pmid":"16977673","source_url":"https://pubmed.ncbi.nlm.nih.gov/16977673/","study_design":null,"title":"The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening","title_match":false,"year":2006},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/practice-parameter-diagnosis-of-dementia-an-evidence-based-review-11342678","doi":"10.1212/wnl.56.9.1143","journal":"Neurology","n_participants":null,"pmid":"11342678","source_url":"https://pubmed.ncbi.nlm.nih.gov/11342678/","study_design":null,"title":"Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology","title_match":false,"year":2001},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/accuracy-of-the-clinical-diagnosis-of-alzheimer-disease-at-national-22437338","doi":"10.1097/nen.0b013e31824b211b","journal":"Journal of neuropathology and experimental neurology","n_participants":1198,"pmid":"22437338","source_url":"https://pubmed.ncbi.nlm.nih.gov/22437338/","study_design":null,"title":"Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010","title_match":false,"year":2012},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/clinical-neurology-and-epidemiology-of-the-major-neurodegenerative-28716886","doi":"10.1101/cshperspect.a033118","journal":"Cold Spring Harbor perspectives in biology","n_participants":null,"pmid":"28716886","source_url":"https://pubmed.ncbi.nlm.nih.gov/28716886/","study_design":null,"title":"Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases","title_match":false,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/movement-disorders-society-scientific-issues-committee-report-sic-12722160","doi":"10.1002/mds.10459","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"12722160","source_url":"https://pubmed.ncbi.nlm.nih.gov/12722160/","study_design":null,"title":"Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders","title_match":false,"year":2003},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-dementia-convergence-of-synuclein-tau-and-amyloid-23900411","doi":"10.1038/nrn3549","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"23900411","source_url":"https://pubmed.ncbi.nlm.nih.gov/23900411/","study_design":null,"title":"Parkinson's disease dementia: convergence of \u03b1-synuclein, tau and amyloid-\u03b2 pathologies","title_match":true,"year":2013},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-neuropathology-of-probable-alzheimer-disease-and-mild-cognitive-19743450","doi":"10.1002/ana.21706","journal":"Annals of neurology","n_participants":54,"pmid":"19743450","source_url":"https://pubmed.ncbi.nlm.nih.gov/19743450/","study_design":null,"title":"The neuropathology of probable Alzheimer disease and mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/classifying-neurocognitive-disorders-the-dsm-5-approach-25266297","doi":"10.1038/nrneurol.2014.181","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"25266297","source_url":"https://pubmed.ncbi.nlm.nih.gov/25266297/","study_design":null,"title":"Classifying neurocognitive disorders: the DSM-5 approach","title_match":false,"year":2014},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/the-distinct-cognitive-syndromes-of-parkinson-s-disease-5-year-follow-19812213","doi":"10.1093/brain/awp245","journal":"Brain : a journal of neurology","n_participants":126,"pmid":"19812213","source_url":"https://pubmed.ncbi.nlm.nih.gov/19812213/","study_design":"cross-sectional","title":"The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort","title_match":false,"year":2009},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/discriminating-synuclein-strains-in-parkinson-s-disease-and-multiple-32025029","doi":"10.1038/s41586-020-1984-7","journal":"Nature","n_participants":null,"pmid":"32025029","source_url":"https://pubmed.ncbi.nlm.nih.gov/32025029/","study_design":null,"title":"Discriminating \u03b1-synuclein strains in Parkinson's disease and multiple system atrophy","title_match":true,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/contribution-of-cerebrovascular-disease-in-autopsy-confirmed-23842566","doi":"10.1093/brain/awt188","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"23842566","source_url":"https://pubmed.ncbi.nlm.nih.gov/23842566/","study_design":null,"title":"Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre","title_match":false,"year":2013},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/evolution-of-cognitive-dysfunction-in-an-incident-parkinson-s-disease-17535834","doi":"10.1093/brain/awm111","journal":"Brain : a journal of neurology","n_participants":126,"pmid":"17535834","source_url":"https://pubmed.ncbi.nlm.nih.gov/17535834/","study_design":"longitudinal study","title":"Evolution of cognitive dysfunction in an incident Parkinson's disease cohort","title_match":false,"year":2007},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/research-criteria-for-the-diagnosis-of-prodromal-dementia-with-lewy-32241955","doi":"10.1212/wnl.0000000000009323","journal":"Neurology","n_participants":null,"pmid":"32241955","source_url":"https://pubmed.ncbi.nlm.nih.gov/32241955/","study_design":null,"title":"Research criteria for the diagnosis of prodromal dementia with Lewy bodies","title_match":true,"year":2020},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/impact-of-multiple-pathologies-on-the-threshold-for-clinically-overt-28488154","doi":"10.1007/s00401-017-1717-7","journal":"Acta neuropathologica","n_participants":null,"pmid":"28488154","source_url":"https://pubmed.ncbi.nlm.nih.gov/28488154/","study_design":"longitudinal study","title":"Impact of multiple pathologies on the threshold for clinically overt dementia","title_match":false,"year":2017},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/efficacy-of-rivastigmine-in-dementia-with-lewy-bodies-a-randomised-11145488","doi":"10.1016/s0140-6736(00)03399-7","journal":"Lancet (London, England)","n_participants":120,"pmid":"11145488","source_url":"https://pubmed.ncbi.nlm.nih.gov/11145488/","study_design":null,"title":"Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study","title_match":true,"year":2000},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/rapid-eye-movement-sleep-behaviour-disorder-as-an-early-marker-for-a-16781987","doi":"10.1016/s1474-4422(06)70476-8","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16781987","source_url":"https://pubmed.ncbi.nlm.nih.gov/16781987/","study_design":null,"title":"Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study","title_match":false,"year":2006},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/delayed-emergence-of-a-parkinsonian-disorder-or-dementia-in-81-of-23347909","doi":"10.1016/j.sleep.2012.10.009","journal":"Sleep medicine","n_participants":13,"pmid":"23347909","source_url":"https://pubmed.ncbi.nlm.nih.gov/23347909/","study_design":null,"title":"Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series","title_match":false,"year":2013},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-diagnosis-of-parkinson-s-disease-16361025","doi":"10.1016/s1474-4422(05)70285-4","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16361025","source_url":"https://pubmed.ncbi.nlm.nih.gov/16361025/","study_design":null,"title":"The diagnosis of Parkinson's disease","title_match":false,"year":2006},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/office-of-rare-diseases-neuropathologic-criteria-for-corticobasal-12430710","doi":"10.1093/jnen/61.11.935","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"12430710","source_url":"https://pubmed.ncbi.nlm.nih.gov/12430710/","study_design":null,"title":"Office of Rare Diseases neuropathologic criteria for corticobasal degeneration","title_match":false,"year":2002},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/validating-novel-tau-positron-emission-tomography-tracer-f-18-av-1451-26344059","doi":"10.1002/ana.24517","journal":"Annals of neurology","n_participants":null,"pmid":"26344059","source_url":"https://pubmed.ncbi.nlm.nih.gov/26344059/","study_design":null,"title":"Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue","title_match":false,"year":2015},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disease-status-and-post-mortem-pathology-in-23562390","doi":"10.1016/s1474-4422(13)70056-5","journal":"The Lancet. Neurology","n_participants":44,"pmid":"23562390","source_url":"https://pubmed.ncbi.nlm.nih.gov/23562390/","study_design":null,"title":"Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study","title_match":false,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/a-biological-definition-of-neuronal-synuclein-disease-towards-an-38267190","doi":"10.1016/s1474-4422(23)00405-2","journal":"The Lancet. Neurology","n_participants":null,"pmid":"38267190","source_url":"https://pubmed.ncbi.nlm.nih.gov/38267190/","study_design":null,"title":"A biological definition of neuronal \u03b1-synuclein disease: towards an integrated staging system for research","title_match":true,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/quantifying-the-risk-of-neurodegenerative-disease-in-idiopathic-rem-19109537","doi":"10.1212/01.wnl.0000340980.19702.6e","journal":"Neurology","n_participants":113,"pmid":"19109537","source_url":"https://pubmed.ncbi.nlm.nih.gov/19109537/","study_design":null,"title":"Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder","title_match":false,"year":2009},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/mini-mental-state-examination-mmse-for-the-detection-of-dementia-in-26760674","doi":"10.1002/14651858.cd011145.pub2","journal":"The Cochrane database of systematic reviews","n_participants":70,"pmid":"26760674","source_url":"https://pubmed.ncbi.nlm.nih.gov/26760674/","study_design":"meta-analysis","title":"Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations","title_match":false,"year":2016},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/synuclein-and-tau-concentrations-in-cerebrospinal-fluid-of-patients-21317042","doi":"10.1016/s1474-4422(11)70014-x","journal":"The Lancet. Neurology","n_participants":null,"pmid":"21317042","source_url":"https://pubmed.ncbi.nlm.nih.gov/21317042/","study_design":"cross-sectional","title":"\u03b1-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study","title_match":true,"year":2011},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/multicenter-standardized-18f-fdg-pet-diagnosis-of-mild-cognitive-18287270","doi":"10.2967/jnumed.107.045385","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":548,"pmid":"18287270","source_url":"https://pubmed.ncbi.nlm.nih.gov/18287270/","study_design":null,"title":"Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias","title_match":false,"year":2008},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/structures-of-synuclein-filaments-from-human-brains-with-lewy-36108674","doi":"10.1038/s41586-022-05319-3","journal":"Nature","n_participants":null,"pmid":"36108674","source_url":"https://pubmed.ncbi.nlm.nih.gov/36108674/","study_design":null,"title":"Structures of \u03b1-synuclein filaments from human brains with Lewy pathology","title_match":true,"year":2022},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/lewy-body-dementias-26595642","doi":"10.1016/s0140-6736(15)00462-6","journal":"Lancet (London, England)","n_participants":null,"pmid":"26595642","source_url":"https://pubmed.ncbi.nlm.nih.gov/26595642/","study_design":null,"title":"Lewy body dementias","title_match":true,"year":2015},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-cortical-lewy-bodies-correlate-with-dementia-in-10822429","doi":"10.1212/wnl.54.10.1916","journal":"Neurology","n_participants":null,"pmid":"10822429","source_url":"https://pubmed.ncbi.nlm.nih.gov/10822429/","study_design":null,"title":"Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease","title_match":true,"year":2000},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/neuropathologic-substrates-of-parkinson-disease-dementia-23037886","doi":"10.1002/ana.23659","journal":"Annals of neurology","n_participants":null,"pmid":"23037886","source_url":"https://pubmed.ncbi.nlm.nih.gov/23037886/","study_design":null,"title":"Neuropathologic substrates of Parkinson disease dementia","title_match":false,"year":2012},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/dementia-caregiver-burden-a-research-update-and-critical-analysis-28795386","doi":"10.1007/s11920-017-0818-2","journal":"Current psychiatry reports","n_participants":null,"pmid":"28795386","source_url":"https://pubmed.ncbi.nlm.nih.gov/28795386/","study_design":null,"title":"Dementia Caregiver Burden: a Research Update and Critical Analysis","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/posterior-cortical-atrophy-22265212","doi":"10.1016/s1474-4422(11)70289-7","journal":"The Lancet. Neurology","n_participants":null,"pmid":"22265212","source_url":"https://pubmed.ncbi.nlm.nih.gov/22265212/","study_design":null,"title":"Posterior cortical atrophy","title_match":false,"year":2012},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/ultrasensitive-rt-quic-assay-with-high-sensitivity-and-specificity-32342188","doi":"10.1007/s00401-020-02160-8","journal":"Acta neuropathologica","n_participants":18,"pmid":"32342188","source_url":"https://pubmed.ncbi.nlm.nih.gov/32342188/","study_design":null,"title":"Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies","title_match":true,"year":2020},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disorder-risk-in-idiopathic-rem-sleep-behavior-24587002","doi":"10.1371/journal.pone.0089741","journal":"PloS one","n_participants":174,"pmid":"24587002","source_url":"https://pubmed.ncbi.nlm.nih.gov/24587002/","study_design":null,"title":"Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients","title_match":false,"year":2014},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-is-related-to-alzheimer-disease-pathology-15753419","doi":"10.1212/01.wnl.0000152982.47274.9e","journal":"Neurology","n_participants":180,"pmid":"15753419","source_url":"https://pubmed.ncbi.nlm.nih.gov/15753419/","study_design":null,"title":"Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions","title_match":false,"year":2005},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cognitive-status-correlates-with-neuropathologic-stage-in-parkinson-15851731","doi":"10.1212/01.wnl.0000158422.41380.82","journal":"Neurology","n_participants":88,"pmid":"15851731","source_url":"https://pubmed.ncbi.nlm.nih.gov/15851731/","study_design":null,"title":"Cognitive status correlates with neuropathologic stage in Parkinson disease","title_match":false,"year":2005},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/dlb-and-pdd-boundary-issues-diagnosis-treatment-molecular-pathology-17353469","doi":"10.1212/01.wnl.0000256715.13907.d3","journal":"Neurology","n_participants":null,"pmid":"17353469","source_url":"https://pubmed.ncbi.nlm.nih.gov/17353469/","study_design":null,"title":"DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers","title_match":true,"year":2007},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/sensitivity-and-specificity-of-dopamine-transporter-imaging-with-123i-17362834","doi":"10.1016/s1474-4422(07)70057-1","journal":"The Lancet. Neurology","n_participants":94,"pmid":"17362834","source_url":"https://pubmed.ncbi.nlm.nih.gov/17362834/","study_design":null,"title":"Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study","title_match":true,"year":2007},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/visual-hallucinations-in-lewy-body-disease-relate-to-lewy-bodies-in-11844739","doi":"10.1093/brain/awf033","journal":"Brain : a journal of neurology","n_participants":29,"pmid":"11844739","source_url":"https://pubmed.ncbi.nlm.nih.gov/11844739/","study_design":null,"title":"Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe","title_match":true,"year":2002},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-in-patients-with-parkinson-s-disease-diagnosis-22814541","doi":"10.1016/s1474-4422(12)70152-7","journal":"The Lancet. Neurology","n_participants":null,"pmid":"22814541","source_url":"https://pubmed.ncbi.nlm.nih.gov/22814541/","study_design":null,"title":"Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/rem-sleep-behaviour-disorder-30166532","doi":"10.1038/s41572-018-0016-5","journal":"Nature reviews. Disease primers","n_participants":null,"pmid":"30166532","source_url":"https://pubmed.ncbi.nlm.nih.gov/30166532/","study_design":null,"title":"REM sleep behaviour disorder","title_match":false,"year":2018},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/time-to-redefine-pd-introductory-statement-of-the-mds-task-force-on-24619848","doi":"10.1002/mds.25844","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"24619848","source_url":"https://pubmed.ncbi.nlm.nih.gov/24619848/","study_design":null,"title":"Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease","title_match":false,"year":2014},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/a-multicenter-study-of-glucocerebrosidase-mutations-in-dementia-with-23588557","doi":"10.1001/jamaneurol.2013.1925","journal":"JAMA neurology","n_participants":null,"pmid":"23588557","source_url":"https://pubmed.ncbi.nlm.nih.gov/23588557/","study_design":"meta-analysis","title":"A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies","title_match":true,"year":2013},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/fdg-pet-changes-in-brain-glucose-metabolism-from-normal-cognition-to-19142633","doi":"10.1007/s00259-008-1039-z","journal":"European journal of nuclear medicine and molecular imaging","n_participants":null,"pmid":"19142633","source_url":"https://pubmed.ncbi.nlm.nih.gov/19142633/","study_design":"longitudinal study","title":"FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/rapid-and-ultra-sensitive-quantitation-of-disease-associated-29422107","doi":"10.1186/s40478-018-0508-2","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"29422107","source_url":"https://pubmed.ncbi.nlm.nih.gov/29422107/","study_design":null,"title":"Rapid and ultra-sensitive quantitation of disease-associated \u03b1-synuclein seeds in brain and cerebrospinal fluid by \u03b1Syn RT-QuIC","title_match":true,"year":2018},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/alzheimer-neuropathologic-alterations-in-aged-cognitively-normal-10218633","doi":"10.1097/00005072-199904000-00008","journal":"Journal of neuropathology and experimental neurology","n_participants":29,"pmid":"10218633","source_url":"https://pubmed.ncbi.nlm.nih.gov/10218633/","study_design":null,"title":"Alzheimer neuropathologic alterations in aged cognitively normal subjects","title_match":false,"year":1999},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/a-single-question-screen-for-rapid-eye-movement-sleep-behavior-22729987","doi":"10.1002/mds.25037","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"22729987","source_url":"https://pubmed.ncbi.nlm.nih.gov/22729987/","study_design":"case-control study","title":"A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study","title_match":false,"year":2012},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-prevalence-and-incidence-of-dementia-with-lewy-bodies-a-23521899","doi":"10.1017/s0033291713000494","journal":"Psychological medicine","n_participants":null,"pmid":"23521899","source_url":"https://pubmed.ncbi.nlm.nih.gov/23521899/","study_design":null,"title":"The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies","title_match":true,"year":2014},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/tdp-43-stage-mixed-pathologies-and-clinical-alzheimer-s-type-dementia-27694152","doi":"10.1093/brain/aww224","journal":"Brain : a journal of neurology","n_participants":398,"pmid":"27694152","source_url":"https://pubmed.ncbi.nlm.nih.gov/27694152/","study_design":null,"title":"TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia","title_match":false,"year":2016},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/neuropathology-underlying-clinical-variability-in-patients-with-21720849","doi":"10.1007/s00401-011-0852-9","journal":"Acta neuropathologica","n_participants":null,"pmid":"21720849","source_url":"https://pubmed.ncbi.nlm.nih.gov/21720849/","study_design":"meta-analysis","title":"Neuropathology underlying clinical variability in patients with synucleinopathies","title_match":false,"year":2011},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/consensus-guidelines-for-the-clinical-and-pathologic-diagnosis-of-16914880","doi":"10.3233/jad-2006-9s347","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"16914880","source_url":"https://pubmed.ncbi.nlm.nih.gov/16914880/","study_design":null,"title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop","title_match":true,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/senile-dementia-of-lewy-body-type-a-clinically-and-2157823","doi":"10.1016/0022-510x(90)90236-g","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"2157823","source_url":"https://pubmed.ncbi.nlm.nih.gov/2157823/","study_design":null,"title":"Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly","title_match":true,"year":1990},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/neuroleptic-sensitivity-in-patients-with-senile-dementia-of-lewy-body-1356550","doi":"10.1136/bmj.305.6855.673","journal":"BMJ (Clinical research ed.)","n_participants":21,"pmid":"1356550","source_url":"https://pubmed.ncbi.nlm.nih.gov/1356550/","study_design":null,"title":"Neuroleptic sensitivity in patients with senile dementia of Lewy body type","title_match":true,"year":1992},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/recommendations-for-the-diagnosis-and-management-of-alzheimer-s-17222085","doi":"10.1111/j.1468-1331.2006.01605.x","journal":"European journal of neurology","n_participants":null,"pmid":"17222085","source_url":"https://pubmed.ncbi.nlm.nih.gov/17222085/","study_design":"meta-analysis","title":"Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline","title_match":false,"year":2007},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/evolution-of-prodromal-parkinson-s-disease-and-dementia-with-lewy-31111143","doi":"10.1093/brain/awz111","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"31111143","source_url":"https://pubmed.ncbi.nlm.nih.gov/31111143/","study_design":"longitudinal study","title":"Evolution of prodromal Parkinson's disease and dementia with Lewy bodies: a prospective study","title_match":true,"year":2019},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/when-dlb-pd-and-psp-masquerade-as-msa-an-autopsy-study-of-134-patients-26138942","doi":"10.1212/wnl.0000000000001807","journal":"Neurology","n_participants":134,"pmid":"26138942","source_url":"https://pubmed.ncbi.nlm.nih.gov/26138942/","study_design":null,"title":"When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients","title_match":true,"year":2015},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-recommendations-of-a-consensus-panel-for-the-screening-diagnosis-28050656","doi":"10.1007/s00415-016-8375-x","journal":"Journal of neurology","n_participants":null,"pmid":"28050656","source_url":"https://pubmed.ncbi.nlm.nih.gov/28050656/","study_design":null,"title":"The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension","title_match":false,"year":2017},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/dlb-fluctuations-specific-features-that-reliably-differentiate-dlb-14745051","doi":"10.1212/wnl.62.2.181","journal":"Neurology","n_participants":200,"pmid":"14745051","source_url":"https://pubmed.ncbi.nlm.nih.gov/14745051/","study_design":null,"title":"DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging","title_match":true,"year":2004},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/multiple-organ-involvement-by-alpha-synuclein-pathology-in-lewy-body-24395122","doi":"10.1002/mds.25776","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"24395122","source_url":"https://pubmed.ncbi.nlm.nih.gov/24395122/","study_design":null,"title":"Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders","title_match":true,"year":2014},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/measurement-of-phosphorylated-tau-epitopes-in-the-differential-14706948","doi":"10.1001/archpsyc.61.1.95","journal":"Archives of general psychiatry","n_participants":206,"pmid":"14706948","source_url":"https://pubmed.ncbi.nlm.nih.gov/14706948/","study_design":"cross-sectional","title":"Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study","title_match":false,"year":2004},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/are-dementia-with-lewy-bodies-and-parkinson-s-disease-dementia-the-29510692","doi":"10.1186/s12916-018-1016-8","journal":"BMC medicine","n_participants":null,"pmid":"29510692","source_url":"https://pubmed.ncbi.nlm.nih.gov/29510692/","study_design":null,"title":"Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?","title_match":true,"year":2018},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/detection-of-biomarkers-with-a-multiplex-quantitative-proteomic-16914840","doi":"10.3233/jad-2006-9309","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"16914840","source_url":"https://pubmed.ncbi.nlm.nih.gov/16914840/","study_design":null,"title":"Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders","title_match":false,"year":2006},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/neuropathology-and-molecular-diagnosis-of-synucleinopathies-34922583","doi":"10.1186/s13024-021-00501-z","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"34922583","source_url":"https://pubmed.ncbi.nlm.nih.gov/34922583/","study_design":null,"title":"Neuropathology and molecular diagnosis of Synucleinopathies","title_match":false,"year":2021},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/detection-of-synuclein-in-csf-by-rt-quic-in-patients-with-isolated-33609478","doi":"10.1016/s1474-4422(20)30449-x","journal":"The Lancet. Neurology","n_participants":52,"pmid":"33609478","source_url":"https://pubmed.ncbi.nlm.nih.gov/33609478/","study_design":"longitudinal study","title":"Detection of \u03b1-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study","title_match":true,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/a-clinicopathological-approach-to-the-diagnosis-of-dementia-28708131","doi":"10.1038/nrneurol.2017.96","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"28708131","source_url":"https://pubmed.ncbi.nlm.nih.gov/28708131/","study_design":null,"title":"A clinicopathological approach to the diagnosis of dementia","title_match":false,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/neuropathologic-outcome-of-mild-cognitive-impairment-following-16682537","doi":"10.1001/archneur.63.5.674","journal":"Archives of neurology","n_participants":null,"pmid":"16682537","source_url":"https://pubmed.ncbi.nlm.nih.gov/16682537/","study_design":null,"title":"Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia","title_match":false,"year":2006},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/glial-fibrillary-acidic-protein-in-serum-is-increased-in-alzheimer-s-30594925","doi":"10.3233/jad-180325","journal":"Journal of Alzheimer's disease : JAD","n_participants":28,"pmid":"30594925","source_url":"https://pubmed.ncbi.nlm.nih.gov/30594925/","study_design":null,"title":"Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/white-matter-lesions-on-magnetic-resonance-imaging-in-dementia-with-10369824","doi":"10.1136/jnnp.67.1.66","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":27,"pmid":"10369824","source_url":"https://pubmed.ncbi.nlm.nih.gov/10369824/","study_design":null,"title":"White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging","title_match":true,"year":1999},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-an-update-and-outlook-30665447","doi":"10.1186/s13024-019-0306-8","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"30665447","source_url":"https://pubmed.ncbi.nlm.nih.gov/30665447/","study_design":null,"title":"Dementia with Lewy bodies: an update and outlook","title_match":true,"year":2019},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/olfactory-bulb-involvement-in-neurodegenerative-diseases-24554308","doi":"10.1007/s00401-014-1261-7","journal":"Acta neuropathologica","n_participants":536,"pmid":"24554308","source_url":"https://pubmed.ncbi.nlm.nih.gov/24554308/","study_design":null,"title":"Olfactory bulb involvement in neurodegenerative diseases","title_match":false,"year":2014},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/a-critical-evaluation-of-the-braak-staging-scheme-for-parkinson-s-19067353","doi":"10.1002/ana.21541","journal":"Annals of neurology","n_participants":null,"pmid":"19067353","source_url":"https://pubmed.ncbi.nlm.nih.gov/19067353/","study_design":null,"title":"A critical evaluation of the Braak staging scheme for Parkinson's disease","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/prospective-validation-of-consensus-criteria-for-the-diagnosis-of-10720273","doi":"10.1212/wnl.54.5.1050","journal":"Neurology","n_participants":null,"pmid":"10720273","source_url":"https://pubmed.ncbi.nlm.nih.gov/10720273/","study_design":null,"title":"Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies","title_match":true,"year":2000},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-with-18-f-florbetaben-in-alzheimer-disease-and-other-21764791","doi":"10.2967/jnumed.111.089730","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":20,"pmid":"21764791","source_url":"https://pubmed.ncbi.nlm.nih.gov/21764791/","study_design":null,"title":"Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias","title_match":false,"year":2011},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-and-beta-amyloid-how-well-do-these-biomarkers-14676043","doi":"10.1001/archneur.60.12.1696","journal":"Archives of neurology","n_participants":74,"pmid":"14676043","source_url":"https://pubmed.ncbi.nlm.nih.gov/14676043/","study_design":null,"title":"Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?","title_match":false,"year":2003},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-clinician-assessment-of-fluctuation-and-the-one-day-fluctuation-11040887","doi":"10.1192/bjp.177.3.252","journal":"The British journal of psychiatry : the journal of mental science","n_participants":40,"pmid":"11040887","source_url":"https://pubmed.ncbi.nlm.nih.gov/11040887/","study_design":null,"title":"The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale. Two methods to assess fluctuating confusion in dementia","title_match":false,"year":2000},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/report-of-the-second-dementia-with-lewy-body-international-workshop-10496243","doi":"10.1212/wnl.53.5.902","journal":"Neurology","n_participants":null,"pmid":"10496243","source_url":"https://pubmed.ncbi.nlm.nih.gov/10496243/","study_design":null,"title":"Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy Bodies","title_match":true,"year":1999},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/natural-history-of-pure-autonomic-failure-a-united-states-prospective-28093795","doi":"10.1002/ana.24877","journal":"Annals of neurology","n_participants":13,"pmid":"28093795","source_url":"https://pubmed.ncbi.nlm.nih.gov/28093795/","study_design":null,"title":"Natural history of pure autonomic failure: A United States prospective cohort","title_match":false,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/prevalence-of-dementia-subtypes-in-united-states-medicare-fee-for-27172148","doi":"10.1016/j.jalz.2016.04.002","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":21,"pmid":"27172148","source_url":"https://pubmed.ncbi.nlm.nih.gov/27172148/","study_design":null,"title":"Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011-2013","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-and-mild-dementia-a-clinical-perspective-25282431","doi":"10.1016/j.mayocp.2014.06.019","journal":"Mayo Clinic proceedings","n_participants":null,"pmid":"25282431","source_url":"https://pubmed.ncbi.nlm.nih.gov/25282431/","study_design":null,"title":"Mild cognitive impairment and mild dementia: a clinical perspective","title_match":false,"year":2014},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/eeg-comparisons-in-early-alzheimer-s-disease-dementia-with-lewy-18202105","doi":"10.1093/brain/awm322","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"18202105","source_url":"https://pubmed.ncbi.nlm.nih.gov/18202105/","study_design":null,"title":"EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up","title_match":true,"year":2008},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/an-autoradiographic-evaluation-of-av-1451-tau-pet-in-dementia-27296779","doi":"10.1186/s40478-016-0315-6","journal":"Acta neuropathologica communications","n_participants":38,"pmid":"27296779","source_url":"https://pubmed.ncbi.nlm.nih.gov/27296779/","study_design":null,"title":"An autoradiographic evaluation of AV-1451 Tau PET in dementia","title_match":false,"year":2016},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/neurodegeneration-associated-with-genetic-defects-in-phospholipase-a-2-18799783","doi":"10.1212/01.wnl.0000327094.67726.28","journal":"Neurology","n_participants":56,"pmid":"18799783","source_url":"https://pubmed.ncbi.nlm.nih.gov/18799783/","study_design":null,"title":"Neurodegeneration associated with genetic defects in phospholipase A(2)","title_match":false,"year":2008},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/susceptibility-weighted-imaging-technical-essentials-and-clinical-33620291","doi":"10.1148/radiol.2021203071","journal":"Radiology","n_participants":null,"pmid":"33620291","source_url":"https://pubmed.ncbi.nlm.nih.gov/33620291/","study_design":null,"title":"Susceptibility-weighted Imaging: Technical Essentials and Clinical Neurologic Applications","title_match":false,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/amyloid-deposition-in-parkinson-s-disease-and-cognitive-impairment-a-25879534","doi":"10.1002/mds.26191","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"25879534","source_url":"https://pubmed.ncbi.nlm.nih.gov/25879534/","study_design":"systematic review","title":"Amyloid deposition in Parkinson's disease and cognitive impairment: a systematic review","title_match":false,"year":2015},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-and-alzheimer-disease-neurodegenerative-20513818","doi":"10.1212/wnl.0b013e3181e0f7cf","journal":"Neurology","n_participants":30,"pmid":"20513818","source_url":"https://pubmed.ncbi.nlm.nih.gov/20513818/","study_design":"case-control study","title":"Dementia with Lewy bodies and Alzheimer disease: neurodegenerative patterns characterized by DTI","title_match":true,"year":2010},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/temporal-lobe-atrophy-on-mri-in-parkinson-disease-with-dementia-a-15753423","doi":"10.1212/01.wnl.0000153070.82309.d4","journal":"Neurology","n_participants":39,"pmid":"15753423","source_url":"https://pubmed.ncbi.nlm.nih.gov/15753423/","study_design":null,"title":"Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies","title_match":true,"year":2005},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/clinical-and-multimodal-biomarker-correlates-of-adni-24252435","doi":"10.1186/2051-5960-1-65","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"24252435","source_url":"https://pubmed.ncbi.nlm.nih.gov/24252435/","study_design":null,"title":"Clinical and multimodal biomarker correlates of ADNI neuropathological findings","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/autoradiography-validation-of-novel-tau-pet-tracer-f-18-mk-6240-on-30857558","doi":"10.1186/s40478-019-0686-6","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"30857558","source_url":"https://pubmed.ncbi.nlm.nih.gov/30857558/","study_design":null,"title":"Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue","title_match":false,"year":2019},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/in-vivo-amyloid-imaging-in-autopsy-confirmed-parkinson-disease-with-20038776","doi":"10.1212/wnl.0b013e3181c7da8e","journal":"Neurology","n_participants":null,"pmid":"20038776","source_url":"https://pubmed.ncbi.nlm.nih.gov/20038776/","study_design":null,"title":"In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia","title_match":false,"year":2010},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-amygdala-as-a-locus-of-pathologic-misfolding-in-neurodegenerative-29186501","doi":"10.1093/jnen/nlx099","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"29186501","source_url":"https://pubmed.ncbi.nlm.nih.gov/29186501/","study_design":null,"title":"The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases","title_match":false,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/gray-matter-atrophy-in-parkinson-disease-with-dementia-and-dementia-17709706","doi":"10.1212/01.wnl.0000269666.62598.1c","journal":"Neurology","n_participants":20,"pmid":"17709706","source_url":"https://pubmed.ncbi.nlm.nih.gov/17709706/","study_design":null,"title":"Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies","title_match":true,"year":2007},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/resting-bold-fmri-differentiates-dementia-with-lewy-bodies-vs-21525427","doi":"10.1212/wnl.0b013e31821ccc83","journal":"Neurology","n_participants":88,"pmid":"21525427","source_url":"https://pubmed.ncbi.nlm.nih.gov/21525427/","study_design":"longitudinal study","title":"Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease","title_match":true,"year":2011},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/small-molecule-pet-tracers-for-imaging-proteinopathies-28826526","doi":"10.1053/j.semnuclmed.2017.06.003","journal":"Seminars in nuclear medicine","n_participants":null,"pmid":"28826526","source_url":"https://pubmed.ncbi.nlm.nih.gov/28826526/","study_design":null,"title":"Small-molecule PET Tracers for Imaging Proteinopathies","title_match":false,"year":2017},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/default-network-is-not-hypoactive-in-dementia-with-fluctuating-23063646","doi":"10.1016/j.neurobiolaging.2012.09.015","journal":"Neurobiology of aging","n_participants":null,"pmid":"23063646","source_url":"https://pubmed.ncbi.nlm.nih.gov/23063646/","study_design":null,"title":"Default network is not hypoactive in dementia with fluctuating cognition: an Alzheimer disease/dementia with Lewy bodies comparison","title_match":true,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/focal-atrophy-on-mri-and-neuropathologic-classification-of-dementia-22843258","doi":"10.1212/wnl.0b013e31826357a5","journal":"Neurology","n_participants":25,"pmid":"22843258","source_url":"https://pubmed.ncbi.nlm.nih.gov/22843258/","study_design":null,"title":"Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies","title_match":true,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/characterizing-dementia-with-lewy-bodies-by-means-of-diffusion-tensor-22895591","doi":"10.1212/wnl.0b013e318266fc51","journal":"Neurology","n_participants":106,"pmid":"22895591","source_url":"https://pubmed.ncbi.nlm.nih.gov/22895591/","study_design":"cross-sectional","title":"Characterizing dementia with Lewy bodies by means of diffusion tensor imaging","title_match":true,"year":2012},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/dementia-after-moderate-severe-traumatic-brain-injury-coexistence-of-29155947","doi":"10.1093/jnen/nlx101","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"29155947","source_url":"https://pubmed.ncbi.nlm.nih.gov/29155947/","study_design":null,"title":"Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/brain-metal-concentrations-in-chronic-liver-failure-patients-with-17159105","doi":"10.1212/01.wnl.0000247037.37807.76","journal":"Neurology","n_participants":null,"pmid":"17159105","source_url":"https://pubmed.ncbi.nlm.nih.gov/17159105/","study_design":null,"title":"Brain metal concentrations in chronic liver failure patients with pallidal T1 MRI hyperintensity","title_match":false,"year":2006},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-12567332","doi":"10.1053/scnp.2003.50006","journal":"Seminars in clinical neuropsychiatry","n_participants":null,"pmid":"12567332","source_url":"https://pubmed.ncbi.nlm.nih.gov/12567332/","study_design":null,"title":"Dementia with Lewy bodies","title_match":true,"year":2003},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/associations-between-tau-amyloid-and-cognition-in-parkinson-disease-29228071","doi":"10.1001/jamaneurol.2017.3713","journal":"JAMA neurology","n_participants":30,"pmid":"29228071","source_url":"https://pubmed.ncbi.nlm.nih.gov/29228071/","study_design":"cross-sectional","title":"Associations Between Tau, \u03b2-Amyloid, and Cognition in Parkinson Disease","title_match":false,"year":2018},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/pattern-of-tau-forms-in-csf-is-altered-in-progressive-supranuclear-17709155","doi":"10.1016/j.neurobiolaging.2007.05.009","journal":"Neurobiology of aging","n_participants":null,"pmid":"17709155","source_url":"https://pubmed.ncbi.nlm.nih.gov/17709155/","study_design":null,"title":"Pattern of Tau forms in CSF is altered in progressive supranuclear palsy","title_match":false,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/vascular-subcortical-hyperintensities-predict-conversion-to-vascular-18436882","doi":"10.1161/strokeaha.107.505206","journal":"Stroke","n_participants":170,"pmid":"18436882","source_url":"https://pubmed.ncbi.nlm.nih.gov/18436882/","study_design":null,"title":"Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients","title_match":false,"year":2008},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/contribution-of-tdp-and-hippocampal-sclerosis-to-hippocampal-volume-31757868","doi":"10.1212/wnl.0000000000008679","journal":"Neurology","n_participants":232,"pmid":"31757868","source_url":"https://pubmed.ncbi.nlm.nih.gov/31757868/","study_design":"cohort study","title":"Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lewy-body-compared-with-alzheimer-dementia-is-associated-with-25035300","doi":"10.1016/j.pscychresns.2014.06.004","journal":"Psychiatry research","n_participants":68,"pmid":"25035300","source_url":"https://pubmed.ncbi.nlm.nih.gov/25035300/","study_design":null,"title":"Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks","title_match":true,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/tau-forms-in-csf-as-a-reliable-biomarker-for-progressive-supranuclear-18971445","doi":"10.1212/01.wnl.0000335941.68602.39","journal":"Neurology","n_participants":166,"pmid":"18971445","source_url":"https://pubmed.ncbi.nlm.nih.gov/18971445/","study_design":null,"title":"Tau forms in CSF as a reliable biomarker for progressive supranuclear palsy","title_match":false,"year":2008},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/differences-between-alzheimer-s-disease-and-dementia-with-lewy-bodies-16670180","doi":"10.1093/brain/awl102","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"16670180","source_url":"https://pubmed.ncbi.nlm.nih.gov/16670180/","study_design":null,"title":"Differences between Alzheimer's disease and dementia with Lewy bodies: an fMRI study of task-related brain activity","title_match":true,"year":2006},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/i-apoe-i-4-white-matter-hyperintensities-and-cognition-in-alzheimer-31575706","doi":"10.1212/wnl.0000000000008377","journal":"Neurology","n_participants":167,"pmid":"31575706","source_url":"https://pubmed.ncbi.nlm.nih.gov/31575706/","study_design":"meta-analysis","title":"APOE \u03b54, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia","title_match":true,"year":2019},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/vascular-cognitive-impairment-12849265","doi":"10.1016/s1474-4422(03)00305-3","journal":"The Lancet. Neurology","n_participants":null,"pmid":"12849265","source_url":"https://pubmed.ncbi.nlm.nih.gov/12849265/","study_design":null,"title":"Vascular cognitive impairment","title_match":false,"year":2003},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/imaging-amyloid-deposition-in-lewy-body-diseases-18794492","doi":"10.1212/01.wnl.0000326146.60732.d6","journal":"Neurology","n_participants":null,"pmid":"18794492","source_url":"https://pubmed.ncbi.nlm.nih.gov/18794492/","study_design":null,"title":"Imaging amyloid deposition in Lewy body diseases","title_match":true,"year":2008},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/memantine-for-patients-with-parkinson-s-disease-dementia-or-dementia-20729148","doi":"10.1016/s1474-4422(10)70194-0","journal":"The Lancet. Neurology","n_participants":199,"pmid":"20729148","source_url":"https://pubmed.ncbi.nlm.nih.gov/20729148/","study_design":null,"title":"Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial","title_match":true,"year":2010},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/novel-antibodies-to-synuclein-show-abundant-striatal-pathology-in-12210791","doi":"10.1002/ana.10279","journal":"Annals of neurology","n_participants":null,"pmid":"12210791","source_url":"https://pubmed.ncbi.nlm.nih.gov/12210791/","study_design":null,"title":"Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases","title_match":true,"year":2002},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/the-relationship-between-cerebral-alzheimer-s-disease-pathology-and-17012338","doi":"10.1136/jnnp.2006.099721","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":166,"pmid":"17012338","source_url":"https://pubmed.ncbi.nlm.nih.gov/17012338/","study_design":null,"title":"The relationship between cerebral Alzheimer's disease pathology and odour identification in old age","title_match":false,"year":2007},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/relation-of-cognitive-activity-to-risk-of-developing-alzheimer-disease-17596582","doi":"10.1212/01.wnl.0000271087.67782.cb","journal":"Neurology","n_participants":90,"pmid":"17596582","source_url":"https://pubmed.ncbi.nlm.nih.gov/17596582/","study_design":null,"title":"Relation of cognitive activity to risk of developing Alzheimer disease","title_match":false,"year":2007},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/staging-and-natural-history-of-cerebrovascular-pathology-in-dementia-22377814","doi":"10.1212/wnl.0b013e31824e8e7f","journal":"Neurology","n_participants":26,"pmid":"22377814","source_url":"https://pubmed.ncbi.nlm.nih.gov/22377814/","study_design":null,"title":"Staging and natural history of cerebrovascular pathology in dementia","title_match":false,"year":2012},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/multiple-pathologies-are-common-and-related-to-dementia-in-the-oldest-26180144","doi":"10.1212/wnl.0000000000001831","journal":"Neurology","n_participants":183,"pmid":"26180144","source_url":"https://pubmed.ncbi.nlm.nih.gov/26180144/","study_design":"longitudinal study","title":"Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/amyloid-beta-a-plaques-promote-seeding-and-spreading-of-alpha-31759806","doi":"10.1016/j.neuron.2019.10.010","journal":"Neuron","n_participants":null,"pmid":"31759806","source_url":"https://pubmed.ncbi.nlm.nih.gov/31759806/","study_design":null,"title":"Amyloid-Beta (A\u03b2) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with A\u03b2 Pathology","title_match":true,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-pathology-does-not-predict-extrapyramidal-symptoms-or-15562510","doi":"10.1002/ana.20321","journal":"Annals of neurology","n_participants":904,"pmid":"15562510","source_url":"https://pubmed.ncbi.nlm.nih.gov/15562510/","study_design":null,"title":"Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia","title_match":true,"year":2005},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/mixed-pathology-is-more-likely-in-black-than-white-decedents-with-26180136","doi":"10.1212/wnl.0000000000001834","journal":"Neurology","n_participants":122,"pmid":"26180136","source_url":"https://pubmed.ncbi.nlm.nih.gov/26180136/","study_design":"cohort study","title":"Mixed pathology is more likely in black than white decedents with Alzheimer dementia","title_match":false,"year":2015},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/physical-frailty-in-older-persons-is-associated-with-alzheimer-18695161","doi":"10.1212/01.wnl.0000324864.81179.6a","journal":"Neurology","n_participants":null,"pmid":"18695161","source_url":"https://pubmed.ncbi.nlm.nih.gov/18695161/","study_design":"longitudinal study","title":"Physical frailty in older persons is associated with Alzheimer disease pathology","title_match":false,"year":2008},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-delirium-with-cognitive-decline-in-late-life-a-28114436","doi":"10.1001/jamapsychiatry.2016.3423","journal":"JAMA psychiatry","n_participants":987,"pmid":"28114436","source_url":"https://pubmed.ncbi.nlm.nih.gov/28114436/","study_design":"cohort study","title":"Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies","title_match":false,"year":2017},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/epidemiological-pathology-of-dementia-attributable-risks-at-death-in-19901977","doi":"10.1371/journal.pmed.1000180","journal":"PLoS medicine","n_participants":null,"pmid":"19901977","source_url":"https://pubmed.ncbi.nlm.nih.gov/19901977/","study_design":"longitudinal study","title":"Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study","title_match":false,"year":2009},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/tau-positron-emission-tomographic-imaging-in-the-lewy-body-diseases-27654968","doi":"10.1001/jamaneurol.2016.3338","journal":"JAMA neurology","n_participants":null,"pmid":"27654968","source_url":"https://pubmed.ncbi.nlm.nih.gov/27654968/","study_design":"cross-sectional","title":"Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases","title_match":true,"year":2016},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/white-matter-lesions-in-parkinson-disease-21343896","doi":"10.1038/nrneurol.2011.21","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"21343896","source_url":"https://pubmed.ncbi.nlm.nih.gov/21343896/","study_design":null,"title":"White matter lesions in Parkinson disease","title_match":false,"year":2011},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuropathologically-mixed-alzheimer-s-and-lewy-body-disease-burden-of-25758940","doi":"10.1007/s00401-015-1406-3","journal":"Acta neuropathologica","n_participants":null,"pmid":"25758940","source_url":"https://pubmed.ncbi.nlm.nih.gov/25758940/","study_design":null,"title":"Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes","title_match":true,"year":2015},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/conscientiousness-and-the-incidence-of-alzheimer-disease-and-mild-17909133","doi":"10.1001/archpsyc.64.10.1204","journal":"Archives of general psychiatry","n_participants":176,"pmid":"17909133","source_url":"https://pubmed.ncbi.nlm.nih.gov/17909133/","study_design":"cohort study","title":"Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/donepezil-for-dementia-with-lewy-bodies-a-randomized-placebo-22829268","doi":"10.1002/ana.23557","journal":"Annals of neurology","n_participants":35,"pmid":"22829268","source_url":"https://pubmed.ncbi.nlm.nih.gov/22829268/","study_design":"clinical trial","title":"Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial","title_match":true,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/glucocerebrosidase-and-parkinson-disease-recent-advances-25802027","doi":"10.1016/j.mcn.2015.03.013","journal":"Molecular and cellular neurosciences","n_participants":null,"pmid":"25802027","source_url":"https://pubmed.ncbi.nlm.nih.gov/25802027/","study_design":null,"title":"Glucocerebrosidase and Parkinson disease: Recent advances","title_match":false,"year":2015},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cognitive-dysfunction-and-dementia-in-parkinson-s-disease-15480840","doi":"10.1007/s00702-004-0168-1","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"15480840","source_url":"https://pubmed.ncbi.nlm.nih.gov/15480840/","study_design":null,"title":"Cognitive dysfunction and dementia in Parkinson's disease","title_match":false,"year":2004},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-prognosis-of-dementia-with-lewy-bodies-28342649","doi":"10.1016/s1474-4422(17)30074-1","journal":"The Lancet. Neurology","n_participants":null,"pmid":"28342649","source_url":"https://pubmed.ncbi.nlm.nih.gov/28342649/","study_design":null,"title":"The prognosis of dementia with Lewy bodies","title_match":true,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/i-apoe-i-genotype-regulates-pathology-and-disease-progression-in-32024799","doi":"10.1126/scitranslmed.aay3069","journal":"Science translational medicine","n_participants":null,"pmid":"32024799","source_url":"https://pubmed.ncbi.nlm.nih.gov/32024799/","study_design":null,"title":"APOE genotype regulates pathology and disease progression in synucleinopathy","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/behavioral-and-psychological-effects-of-coronavirus-disease-19-33033486","doi":"10.3389/fpsyt.2020.578015","journal":"Frontiers in psychiatry","n_participants":4913,"pmid":"33033486","source_url":"https://pubmed.ncbi.nlm.nih.gov/33033486/","study_design":null,"title":"Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia","title_match":false,"year":2020},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/pharmacological-management-of-lewy-body-dementia-a-systematic-review-26085043","doi":"10.1176/appi.ajp.2015.14121582","journal":"The American journal of psychiatry","n_participants":null,"pmid":"26085043","source_url":"https://pubmed.ncbi.nlm.nih.gov/26085043/","study_design":"meta-analysis","title":"Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis","title_match":true,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/neuropathologic-comorbidity-and-cognitive-impairment-in-the-nun-and-26888993","doi":"10.1212/wnl.0000000000002480","journal":"Neurology","n_participants":null,"pmid":"26888993","source_url":"https://pubmed.ncbi.nlm.nih.gov/26888993/","study_design":null,"title":"Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies","title_match":false,"year":2016},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/differential-circadian-rhythm-disturbances-in-men-with-alzheimer-11296096","doi":"10.1001/archpsyc.58.4.353","journal":"Archives of general psychiatry","n_participants":23,"pmid":"11296096","source_url":"https://pubmed.ncbi.nlm.nih.gov/11296096/","study_design":null,"title":"Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration","title_match":false,"year":2001},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/ecology-of-the-aging-human-brain-21825242","doi":"10.1001/archneurol.2011.157","journal":"Archives of neurology","n_participants":1672,"pmid":"21825242","source_url":"https://pubmed.ncbi.nlm.nih.gov/21825242/","study_design":null,"title":"Ecology of the aging human brain","title_match":false,"year":2011},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/neuropathological-correlates-of-dopaminergic-imaging-in-alzheimer-s-22961551","doi":"10.1093/brain/aws211","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"22961551","source_url":"https://pubmed.ncbi.nlm.nih.gov/22961551/","study_design":null,"title":"Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias","title_match":true,"year":2012},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-prevalence-and-incidence-of-dementia-with-lewy-bodies-a-27307129","doi":"10.1017/cjn.2016.2","journal":"The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques","n_participants":1000,"pmid":"27307129","source_url":"https://pubmed.ncbi.nlm.nih.gov/27307129/","study_design":null,"title":"The Prevalence and Incidence of Dementia with Lewy Bodies: a Systematic Review","title_match":true,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cortical-alpha-synuclein-load-is-associated-with-amyloid-beta-plaque-18185940","doi":"10.1007/s00401-007-0336-0","journal":"Acta neuropathologica","n_participants":null,"pmid":"18185940","source_url":"https://pubmed.ncbi.nlm.nih.gov/18185940/","study_design":null,"title":"Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients","title_match":true,"year":2008},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-contribution-of-tau-amyloid-beta-and-alpha-synuclein-pathology-to-30473927","doi":"10.4172/2161-0460.1000444","journal":"Journal of Alzheimer's disease & Parkinsonism","n_participants":null,"pmid":"30473927","source_url":"https://pubmed.ncbi.nlm.nih.gov/30473927/","study_design":null,"title":"The Contribution of Tau, Amyloid-Beta and Alpha-Synuclein Pathology to Dementia in Lewy Body Disorders","title_match":true,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-pathology-of-the-substantia-nigra-in-alzheimer-disease-with-15851730","doi":"10.1212/01.wnl.0000158423.05224.7f","journal":"Neurology","n_participants":104,"pmid":"15851730","source_url":"https://pubmed.ncbi.nlm.nih.gov/15851730/","study_design":null,"title":"The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs","title_match":false,"year":2005},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/nicotinic-acetylcholine-receptors-and-nicotinic-cholinergic-17009926","doi":"10.1146/annurev.pharmtox.47.120505.105214","journal":"Annual review of pharmacology and toxicology","n_participants":null,"pmid":"17009926","source_url":"https://pubmed.ncbi.nlm.nih.gov/17009926/","study_design":null,"title":"Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system","title_match":false,"year":2007},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/ubiquitin-immunoreactive-intraneuronal-inclusions-in-amyotrophic-1646064","doi":"10.1093/brain/114.2.775","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"1646064","source_url":"https://pubmed.ncbi.nlm.nih.gov/1646064/","study_design":null,"title":"Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity","title_match":false,"year":1991},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/what-best-differentiates-lewy-body-from-alzheimer-s-disease-in-early-16401618","doi":"10.1093/brain/awh725","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"16401618","source_url":"https://pubmed.ncbi.nlm.nih.gov/16401618/","study_design":null,"title":"What best differentiates Lewy body from Alzheimer's disease in early-stage dementia?","title_match":true,"year":2006},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/cellular-co-localization-of-phosphorylated-tau-and-nacp-alpha-10528110","doi":"10.1016/s0006-8993(99)01848-x","journal":"Brain research","n_participants":null,"pmid":"10528110","source_url":"https://pubmed.ncbi.nlm.nih.gov/10528110/","study_design":null,"title":"Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies","title_match":true,"year":1999},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/combined-neuropathological-pathways-account-for-age-related-risk-of-29944741","doi":"10.1002/ana.25246","journal":"Annals of neurology","n_participants":null,"pmid":"29944741","source_url":"https://pubmed.ncbi.nlm.nih.gov/29944741/","study_design":null,"title":"Combined neuropathological pathways account for age-related risk of dementia","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-genetic-landscape-of-parkinson-s-disease-30245141","doi":"10.1016/j.neurol.2018.08.004","journal":"Revue neurologique","n_participants":null,"pmid":"30245141","source_url":"https://pubmed.ncbi.nlm.nih.gov/30245141/","study_design":null,"title":"The genetic landscape of Parkinson's disease","title_match":false,"year":2018},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-related-dementias-summit-2016-national-research-29117955","doi":"10.1212/wnl.0000000000004717","journal":"Neurology","n_participants":null,"pmid":"29117955","source_url":"https://pubmed.ncbi.nlm.nih.gov/29117955/","study_design":null,"title":"Alzheimer's Disease-Related Dementias Summit 2016: National research priorities","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/recommendations-of-the-alzheimer-s-disease-related-dementias-25080517","doi":"10.1212/wnl.0000000000000733","journal":"Neurology","n_participants":null,"pmid":"25080517","source_url":"https://pubmed.ncbi.nlm.nih.gov/25080517/","study_design":null,"title":"Recommendations of the Alzheimer's disease-related dementias conference","title_match":false,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/an-evaluation-of-the-predictive-validity-and-inter-rater-reliability-8190290","doi":"10.1212/wnl.44.5.872","journal":"Neurology","n_participants":null,"pmid":"8190290","source_url":"https://pubmed.ncbi.nlm.nih.gov/8190290/","study_design":null,"title":"An evaluation of the predictive validity and inter-rater reliability of clinical diagnostic criteria for senile dementia of Lewy body type","title_match":true,"year":1994},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/behavioural-and-psychological-symptoms-of-dementia-correlates-and-29282408","doi":"10.1159/000481568","journal":"Dementia and geriatric cognitive disorders extra","n_participants":107,"pmid":"29282408","source_url":"https://pubmed.ncbi.nlm.nih.gov/29282408/","study_design":"cross-sectional","title":"Behavioural and Psychological Symptoms of Dementia: Correlates and Impact on Caregiver Distress","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/criteria-for-alzheimer-s-disease-and-the-nosology-of-dementia-with-9008507","doi":"10.1212/wnl.48.1.126","journal":"Neurology","n_participants":null,"pmid":"9008507","source_url":"https://pubmed.ncbi.nlm.nih.gov/9008507/","study_design":null,"title":"Criteria for Alzheimer's disease and the nosology of dementia with Lewy bodies","title_match":true,"year":1997},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-neuropathological-comorbidities-are-common-in-the-33285640","doi":"10.3233/jad-201213","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"33285640","source_url":"https://pubmed.ncbi.nlm.nih.gov/33285640/","study_design":null,"title":"Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old","title_match":false,"year":2021},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/structure-of-alpha-synuclein-fibrils-derived-from-human-lewy-body-38553463","doi":"10.1038/s41467-024-46832-5","journal":"Nature communications","n_participants":null,"pmid":"38553463","source_url":"https://pubmed.ncbi.nlm.nih.gov/38553463/","study_design":null,"title":"Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/multicentre-population-based-dementia-prevalence-survey-in-japan-a-22712646","doi":"10.1111/j.1479-8301.2012.00415.x","journal":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","n_participants":3394,"pmid":"22712646","source_url":"https://pubmed.ncbi.nlm.nih.gov/22712646/","study_design":null,"title":"Multicentre population-based dementia prevalence survey in Japan: a preliminary report","title_match":false,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/prevalence-of-alzheimer-s-disease-vascular-dementia-and-dementia-with-11235852","doi":"10.1046/j.1440-1819.2001.00779.x","journal":"Psychiatry and clinical neurosciences","n_participants":170,"pmid":"11235852","source_url":"https://pubmed.ncbi.nlm.nih.gov/11235852/","study_design":null,"title":"Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population","title_match":true,"year":2001},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/atypical-parkinsonism-in-afro-caribbean-and-indian-origin-immigrants-10634237","doi":"10.1002/1531-8257(200001)15:1<18::aid-mds1005>3.0.co;2-z","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"10634237","source_url":"https://pubmed.ncbi.nlm.nih.gov/10634237/","study_design":null,"title":"Atypical parkinsonism in Afro-Caribbean and Indian origin immigrants to the UK","title_match":false,"year":2000},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/risk-factors-for-phenoconversion-in-rapid-eye-movement-sleep-behavior-34981563","doi":"10.1002/ana.26298","journal":"Annals of neurology","n_participants":319,"pmid":"34981563","source_url":"https://pubmed.ncbi.nlm.nih.gov/34981563/","study_design":null,"title":"Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/parkinson-disease-associated-cognitive-impairment-34210995","doi":"10.1038/s41572-021-00280-3","journal":"Nature reviews. Disease primers","n_participants":null,"pmid":"34210995","source_url":"https://pubmed.ncbi.nlm.nih.gov/34210995/","study_design":null,"title":"Parkinson disease-associated cognitive impairment","title_match":false,"year":2021},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/the-lewy-body-variant-of-alzheimer-s-disease-a-clinical-and-2153271","doi":"10.1212/wnl.40.1.1","journal":"Neurology","n_participants":13,"pmid":"2153271","source_url":"https://pubmed.ncbi.nlm.nih.gov/2153271/","study_design":null,"title":"The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity","title_match":true,"year":1990},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-a-review-24389262","doi":"10.2741/s415","journal":"Frontiers in bioscience (Scholar edition)","n_participants":null,"pmid":"24389262","source_url":"https://pubmed.ncbi.nlm.nih.gov/24389262/","study_design":null,"title":"Parkinson's disease: a review","title_match":false,"year":2014},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/cerebral-atrophy-in-parkinson-s-disease-with-and-without-dementia-a-14749292","doi":"10.1093/brain/awh088","journal":"Brain : a journal of neurology","n_participants":26,"pmid":"14749292","source_url":"https://pubmed.ncbi.nlm.nih.gov/14749292/","study_design":"cross-sectional","title":"Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls","title_match":true,"year":2004},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-evolution-and-pathology-of-frontotemporal-dementia-16033782","doi":"10.1093/brain/awh598","journal":"Brain : a journal of neurology","n_participants":32,"pmid":"16033782","source_url":"https://pubmed.ncbi.nlm.nih.gov/16033782/","study_design":null,"title":"The evolution and pathology of frontotemporal dementia","title_match":false,"year":2005},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/co-morbidity-of-tdp-43-proteinopathy-in-lewy-body-related-diseases-17653732","doi":"10.1007/s00401-007-0261-2","journal":"Acta neuropathologica","n_participants":null,"pmid":"17653732","source_url":"https://pubmed.ncbi.nlm.nih.gov/17653732/","study_design":null,"title":"Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases","title_match":true,"year":2007},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/concurrence-of-tdp-43-tau-and-alpha-synuclein-pathology-in-brains-of-17963732","doi":"10.1016/j.brainres.2007.09.048","journal":"Brain research","n_participants":null,"pmid":"17963732","source_url":"https://pubmed.ncbi.nlm.nih.gov/17963732/","study_design":null,"title":"Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies","title_match":true,"year":2007},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-traumatic-brain-injury-with-late-life-27400367","doi":"10.1001/jamaneurol.2016.1948","journal":"JAMA neurology","n_participants":7130,"pmid":"27400367","source_url":"https://pubmed.ncbi.nlm.nih.gov/27400367/","study_design":"cohort study","title":"Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings","title_match":false,"year":2016},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/parkinson-risk-in-idiopathic-rem-sleep-behavior-disorder-preparing-25681454","doi":"10.1212/wnl.0000000000001364","journal":"Neurology","n_participants":89,"pmid":"25681454","source_url":"https://pubmed.ncbi.nlm.nih.gov/25681454/","study_design":"prospective cohort","title":"Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials","title_match":false,"year":2015},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-neuropathology-and-cerebrovascular-mechanisms-of-dementia-26174330","doi":"10.1038/jcbfm.2015.164","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"26174330","source_url":"https://pubmed.ncbi.nlm.nih.gov/26174330/","study_design":null,"title":"The neuropathology and cerebrovascular  mechanisms of dementia","title_match":false,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/aggresomes-formed-by-alpha-synuclein-and-synphilin-1-are-14627698","doi":"10.1074/jbc.m310994200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"14627698","source_url":"https://pubmed.ncbi.nlm.nih.gov/14627698/","study_design":null,"title":"Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective","title_match":true,"year":2004},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/pathological-correlates-of-dementia-in-a-longitudinal-population-17879383","doi":"10.1002/ana.21208","journal":"Annals of neurology","n_participants":221,"pmid":"17879383","source_url":"https://pubmed.ncbi.nlm.nih.gov/17879383/","study_design":"longitudinal study","title":"Pathological correlates of dementia in a longitudinal, population-based sample of aging","title_match":false,"year":2007},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-neuropathology-of-older-persons-with-and-without-dementia-from-19749406","doi":"10.3233/jad-2009-1227","journal":"Journal of Alzheimer's disease : JAD","n_participants":386,"pmid":"19749406","source_url":"https://pubmed.ncbi.nlm.nih.gov/19749406/","study_design":null,"title":"The neuropathology of older persons with and without dementia from community versus clinic cohorts","title_match":false,"year":2009},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/conversion-from-subtypes-of-mild-cognitive-impairment-to-alzheimer-17242334","doi":"10.1212/01.wnl.0000252358.03285.9d","journal":"Neurology","n_participants":1505,"pmid":"17242334","source_url":"https://pubmed.ncbi.nlm.nih.gov/17242334/","study_design":null,"title":"Conversion from subtypes of mild cognitive impairment to Alzheimer dementia","title_match":false,"year":2007},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/motor-subtype-and-cognitive-decline-in-parkinson-s-disease-parkinson-16614017","doi":"10.1136/jnnp.2005.081711","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":40,"pmid":"16614017","source_url":"https://pubmed.ncbi.nlm.nih.gov/16614017/","study_design":null,"title":"Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies","title_match":true,"year":2006},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/disease-related-microglia-heterogeneity-in-the-hippocampus-of-26001591","doi":"10.1186/s40478-015-0209-z","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"26001591","source_url":"https://pubmed.ncbi.nlm.nih.gov/26001591/","study_design":null,"title":"Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging","title_match":true,"year":2015},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/increased-csf-neurogranin-concentration-is-specific-to-alzheimer-26826204","doi":"10.1212/wnl.0000000000002423","journal":"Neurology","n_participants":19,"pmid":"26826204","source_url":"https://pubmed.ncbi.nlm.nih.gov/26826204/","study_design":"retrospective cohort","title":"Increased CSF neurogranin concentration is specific to Alzheimer disease","title_match":false,"year":2016},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/clinical-characteristics-of-a-family-with-chromosome-17-linked-7936241","doi":"10.1212/wnl.44.10.1878","journal":"Neurology","n_participants":null,"pmid":"7936241","source_url":"https://pubmed.ncbi.nlm.nih.gov/7936241/","study_design":null,"title":"Clinical characteristics of a family with chromosome 17-linked disinhibition-dementia-parkinsonism-amyotrophy complex","title_match":false,"year":1994},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/neuroinflammation-and-protein-pathology-in-parkinson-s-disease-33272323","doi":"10.1186/s40478-020-01083-5","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"33272323","source_url":"https://pubmed.ncbi.nlm.nih.gov/33272323/","study_design":null,"title":"Neuroinflammation and protein pathology in Parkinson's disease dementia","title_match":false,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/improving-diagnostic-accuracy-of-multiple-system-atrophy-a-31289815","doi":"10.1093/brain/awz189","journal":"Brain : a journal of neurology","n_participants":26,"pmid":"31289815","source_url":"https://pubmed.ncbi.nlm.nih.gov/31289815/","study_design":null,"title":"Improving diagnostic accuracy of multiple system atrophy: a clinicopathological study","title_match":false,"year":2019},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cognitive-and-pathological-influences-of-tau-pathology-in-lewy-body-30549331","doi":"10.1002/ana.25392","journal":"Annals of neurology","n_participants":36,"pmid":"30549331","source_url":"https://pubmed.ncbi.nlm.nih.gov/30549331/","study_design":null,"title":"Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders","title_match":true,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/age-and-disease-dependent-increase-of-the-mitophagy-marker-phospho-29947276","doi":"10.1080/15548627.2018.1461294","journal":"Autophagy","n_participants":null,"pmid":"29947276","source_url":"https://pubmed.ncbi.nlm.nih.gov/29947276/","study_design":null,"title":"Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease","title_match":true,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/familial-frontotemporal-dementia-with-ubiquitin-positive-inclusions-11571213","doi":"10.1093/brain/124.10.1948","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"11571213","source_url":"https://pubmed.ncbi.nlm.nih.gov/11571213/","study_design":null,"title":"Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22","title_match":false,"year":2001},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-limbic-and-neocortical-contribution-of-synuclein-tau-and-amyloid-29100980","doi":"10.1016/j.jalz.2017.09.014","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":49,"pmid":"29100980","source_url":"https://pubmed.ncbi.nlm.nih.gov/29100980/","study_design":null,"title":"The limbic and neocortical contribution of \u03b1-synuclein, tau, and amyloid \u03b2 to disease duration in dementia with Lewy bodies","title_match":true,"year":2018},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-clinical-spectrum-of-freezing-of-gait-in-atypical-parkinsonism-18668624","doi":"10.1002/mds.21849","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"18668624","source_url":"https://pubmed.ncbi.nlm.nih.gov/18668624/","study_design":null,"title":"The clinical spectrum of freezing of gait in atypical parkinsonism","title_match":false,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/social-inappropriateness-in-neurodegenerative-disorders-28689508","doi":"10.1017/s1041610217001260","journal":"International psychogeriatrics","n_participants":null,"pmid":"28689508","source_url":"https://pubmed.ncbi.nlm.nih.gov/28689508/","study_design":null,"title":"Social inappropriateness in neurodegenerative disorders","title_match":false,"year":2018},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-4-carriers-share-immune-related-proteomic-changes-across-40665049","doi":"10.1038/s41591-025-03835-z","journal":"Nature medicine","n_participants":null,"pmid":"40665049","source_url":"https://pubmed.ncbi.nlm.nih.gov/40665049/","study_design":null,"title":"APOE \u03b54 carriers share immune-related proteomic changes across neurodegenerative diseases","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/differentiating-dementia-disease-subtypes-with-gait-analysis-31901765","doi":"10.1016/j.gaitpost.2019.12.028","journal":"Gait & posture","n_participants":80,"pmid":"31901765","source_url":"https://pubmed.ncbi.nlm.nih.gov/31901765/","study_design":"post-hoc analysis","title":"Differentiating dementia disease subtypes with gait analysis: feasibility of wearable sensors?","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/an-analysis-of-communication-in-conversation-in-patients-with-dementia-20888846","doi":"10.1016/j.neuropsychologia.2010.09.026","journal":"Neuropsychologia","n_participants":null,"pmid":"20888846","source_url":"https://pubmed.ncbi.nlm.nih.gov/20888846/","study_design":null,"title":"An analysis of communication in conversation in patients with dementia","title_match":false,"year":2010},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/machine-learning-identified-an-alzheimer-s-disease-related-fdg-pet-30185806","doi":"10.1038/s41598-018-31653-6","journal":"Scientific reports","n_participants":null,"pmid":"30185806","source_url":"https://pubmed.ncbi.nlm.nih.gov/30185806/","study_design":null,"title":"Machine learning identified an Alzheimer's disease-related FDG-PET pattern which is also expressed in Lewy body dementia and Parkinson's disease dementia","title_match":true,"year":2018},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/differential-insular-cortex-sub-regional-atrophy-in-neurodegenerative-31011951","doi":"10.1007/s11682-019-00099-3","journal":"Brain imaging and behavior","n_participants":2261,"pmid":"31011951","source_url":"https://pubmed.ncbi.nlm.nih.gov/31011951/","study_design":"systematic review","title":"Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis","title_match":false,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/mri-and-pathology-of-rem-sleep-behavior-disorder-in-dementia-with-24107861","doi":"10.1212/01.wnl.0000435299.57153.f0","journal":"Neurology","n_participants":75,"pmid":"24107861","source_url":"https://pubmed.ncbi.nlm.nih.gov/24107861/","study_design":null,"title":"MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies","title_match":true,"year":2013},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/progressive-supranuclear-palsy-presenting-as-primary-lateral-23026537","doi":"10.1016/j.jns.2012.09.005","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"23026537","source_url":"https://pubmed.ncbi.nlm.nih.gov/23026537/","study_design":null,"title":"Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia","title_match":false,"year":2012},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/impairments-of-speech-fluency-in-lewy-body-spectrum-disorder-22099969","doi":"10.1016/j.bandl.2011.09.004","journal":"Brain and language","n_participants":35,"pmid":"22099969","source_url":"https://pubmed.ncbi.nlm.nih.gov/22099969/","study_design":null,"title":"Impairments of speech fluency in Lewy body spectrum disorder","title_match":true,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/advances-in-deep-neuropathological-phenotyping-of-alzheimer-disease-34981115","doi":"10.1093/jnen/nlab122","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"34981115","source_url":"https://pubmed.ncbi.nlm.nih.gov/34981115/","study_design":null,"title":"Advances in Deep Neuropathological Phenotyping of Alzheimer Disease: Past, Present, and Future","title_match":false,"year":2022},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/presynaptic-dopaminergic-imaging-characterizes-patients-with-rem-38466158","doi":"10.1002/ana.26902","journal":"Annals of neurology","n_participants":173,"pmid":"38466158","source_url":"https://pubmed.ncbi.nlm.nih.gov/38466158/","study_design":null,"title":"Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy","title_match":false,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/the-role-of-eeg-in-the-diagnosis-prognosis-and-clinical-correlations-32825520","doi":"10.3390/diagnostics10090616","journal":"Diagnostics (Basel, Switzerland)","n_participants":43,"pmid":"32825520","source_url":"https://pubmed.ncbi.nlm.nih.gov/32825520/","study_design":"systematic review","title":"The Role of EEG in the Diagnosis, Prognosis and Clinical Correlations of Dementia with Lewy Bodies-A Systematic Review","title_match":true,"year":2020},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/prediction-models-for-dementia-and-neuropathology-in-the-oldest-old-30670070","doi":"10.1186/s13195-018-0450-3","journal":"Alzheimer's research & therapy","n_participants":245,"pmid":"30670070","source_url":"https://pubmed.ncbi.nlm.nih.gov/30670070/","study_design":null,"title":"Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study","title_match":false,"year":2019},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/cognition-language-and-clinical-pathological-features-of-non-20493496","doi":"10.1016/j.jcomdis.2010.04.011","journal":"Journal of communication disorders","n_participants":null,"pmid":"20493496","source_url":"https://pubmed.ncbi.nlm.nih.gov/20493496/","study_design":null,"title":"Cognition, language, and clinical pathological features of non-Alzheimer's dementias: an overview","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/quantitative-detection-of-synuclein-and-tau-oligomers-and-other-35655068","doi":"10.1038/s41531-022-00330-x","journal":"NPJ Parkinson's disease","n_participants":null,"pmid":"35655068","source_url":"https://pubmed.ncbi.nlm.nih.gov/35655068/","study_design":null,"title":"Quantitative detection of \u03b1-Synuclein and Tau oligomers and other aggregates by digital single particle counting","title_match":true,"year":2022},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/frontotemporal-dementia-a-review-for-primary-care-physicians-21121521","doi":null,"journal":"American family physician","n_participants":null,"pmid":"21121521","source_url":"https://pubmed.ncbi.nlm.nih.gov/21121521/","study_design":null,"title":"Frontotemporal dementia: a review for primary care physicians","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/dementia-lacking-distinctive-histopathology-clinicopathological-7610766","doi":"10.1007/bf00309628","journal":"Acta neuropathologica","n_participants":32,"pmid":"7610766","source_url":"https://pubmed.ncbi.nlm.nih.gov/7610766/","study_design":null,"title":"Dementia lacking distinctive histopathology: clinicopathological evaluation of 32 cases","title_match":false,"year":1995},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/classifications-of-neurodegenerative-disorders-using-a-multiplex-32967146","doi":"10.3390/ijms21186914","journal":"International journal of molecular sciences","n_participants":377,"pmid":"32967146","source_url":"https://pubmed.ncbi.nlm.nih.gov/32967146/","study_design":null,"title":"Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model","title_match":false,"year":2020},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-in-parkinson-s-disease-and-other-synucleinopathies-36859484","doi":"10.1038/s41419-023-05672-9","journal":"Cell death & disease","n_participants":null,"pmid":"36859484","source_url":"https://pubmed.ncbi.nlm.nih.gov/36859484/","study_design":null,"title":"Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction","title_match":true,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/glucocerebrosidase-mutations-in-clinical-and-pathologically-proven-19286695","doi":"10.1093/brain/awp044","journal":"Brain : a journal of neurology","n_participants":790,"pmid":"19286695","source_url":"https://pubmed.ncbi.nlm.nih.gov/19286695/","study_design":null,"title":"Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease","title_match":false,"year":2009},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/acetylcholine-in-mind-a-neurotransmitter-correlate-of-consciousness-10354606","doi":"10.1016/s0166-2236(98)01361-7","journal":"Trends in neurosciences","n_participants":null,"pmid":"10354606","source_url":"https://pubmed.ncbi.nlm.nih.gov/10354606/","study_design":null,"title":"Acetylcholine in mind: a neurotransmitter correlate of consciousness?","title_match":false,"year":1999},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-aging-brain-18039130","doi":"10.1146/annurev.pathmechdis.2.010506.092044","journal":"Annual review of pathology","n_participants":null,"pmid":"18039130","source_url":"https://pubmed.ncbi.nlm.nih.gov/18039130/","study_design":null,"title":"The aging brain","title_match":false,"year":2008},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-is-part-of-a-diverse-and-highly-conserved-interaction-19182805","doi":"10.1038/ng.300","journal":"Nature genetics","n_participants":null,"pmid":"19182805","source_url":"https://pubmed.ncbi.nlm.nih.gov/19182805/","study_design":null,"title":"Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity","title_match":true,"year":2009},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/idiopathic-rem-sleep-behaviour-disorder-and-neurodegeneration-an-29170501","doi":"10.1038/nrneurol.2017.157","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"29170501","source_url":"https://pubmed.ncbi.nlm.nih.gov/29170501/","study_design":null,"title":"Idiopathic REM sleep behaviour disorder and neurodegeneration - an update","title_match":false,"year":2018},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/association-of-rem-sleep-behavior-disorder-and-neurodegenerative-11481685","doi":"10.1002/mds.1120","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"11481685","source_url":"https://pubmed.ncbi.nlm.nih.gov/11481685/","study_design":null,"title":"Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy","title_match":false,"year":2001},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/ageing-neurodegeneration-and-parkinson-s-disease-20051606","doi":"10.1093/ageing/afp223","journal":"Age and ageing","n_participants":null,"pmid":"20051606","source_url":"https://pubmed.ncbi.nlm.nih.gov/20051606/","study_design":null,"title":"Ageing, neurodegeneration and Parkinson's disease","title_match":false,"year":2010},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/complex-visual-hallucinations-clinical-and-neurobiological-insights-9798740","doi":"10.1093/brain/121.10.1819","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"9798740","source_url":"https://pubmed.ncbi.nlm.nih.gov/9798740/","study_design":null,"title":"Complex visual hallucinations. Clinical and neurobiological insights","title_match":false,"year":1998},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/synuclein-in-the-pathophysiology-of-alzheimer-s-disease-31186026","doi":"10.1186/s13024-019-0320-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31186026","source_url":"https://pubmed.ncbi.nlm.nih.gov/31186026/","study_design":null,"title":"\u03b1-synuclein in the pathophysiology of Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-dementias-12480441","doi":"10.1016/s0140-6736(02)11667-9","journal":"Lancet (London, England)","n_participants":null,"pmid":"12480441","source_url":"https://pubmed.ncbi.nlm.nih.gov/12480441/","study_design":null,"title":"The dementias","title_match":false,"year":2002},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinicopathologic-correlations-in-172-cases-of-rapid-eye-movement-23474058","doi":"10.1016/j.sleep.2012.10.015","journal":"Sleep medicine","n_participants":147,"pmid":"23474058","source_url":"https://pubmed.ncbi.nlm.nih.gov/23474058/","study_design":null,"title":"Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/brain-ferritin-iron-may-influence-age-and-gender-related-risks-of-16563566","doi":"10.1016/j.neurobiolaging.2006.02.005","journal":"Neurobiology of aging","n_participants":null,"pmid":"16563566","source_url":"https://pubmed.ncbi.nlm.nih.gov/16563566/","study_design":null,"title":"Brain ferritin iron may influence age- and gender-related risks of neurodegeneration","title_match":false,"year":2007},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-cascade-hypothesis-in-the-pathogenesis-of-alzheimer-s-disease-35298921","doi":"10.1016/j.neuron.2022.03.004","journal":"Neuron","n_participants":null,"pmid":"35298921","source_url":"https://pubmed.ncbi.nlm.nih.gov/35298921/","study_design":null,"title":"ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/the-risk-of-neurodegeneration-in-rem-sleep-behavior-disorder-a-30503716","doi":"10.1016/j.smrv.2018.09.008","journal":"Sleep medicine reviews","n_participants":null,"pmid":"30503716","source_url":"https://pubmed.ncbi.nlm.nih.gov/30503716/","study_design":"meta-analysis","title":"The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies","title_match":false,"year":2019},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/prevalence-of-sleep-disturbances-in-mild-cognitive-impairment-and-22415141","doi":"10.1159/000335363","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"22415141","source_url":"https://pubmed.ncbi.nlm.nih.gov/22415141/","study_design":null,"title":"Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients","title_match":false,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/rem-sleep-behavior-disorder-preceding-other-aspects-of-20668263","doi":"10.1212/wnl.0b013e3181ec7fac","journal":"Neurology","n_participants":27,"pmid":"20668263","source_url":"https://pubmed.ncbi.nlm.nih.gov/20668263/","study_design":null,"title":"REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century","title_match":false,"year":2010},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/in-vivo-staging-of-pathology-in-rem-sleep-behaviour-disorder-a-29866443","doi":"10.1016/s1474-4422(18)30162-5","journal":"The Lancet. Neurology","n_participants":22,"pmid":"29866443","source_url":"https://pubmed.ncbi.nlm.nih.gov/29866443/","study_design":"case-control study","title":"In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study","title_match":false,"year":2018},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/how-does-parkinsonism-start-prodromal-parkinsonism-motor-changes-in-22561644","doi":"10.1093/brain/aws093","journal":"Brain : a journal of neurology","n_participants":78,"pmid":"22561644","source_url":"https://pubmed.ncbi.nlm.nih.gov/22561644/","study_design":"cohort study","title":"How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder","title_match":false,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/sleep-and-quantitative-eeg-in-neurodegenerative-disorders-15172204","doi":"10.1016/j.jpsychores.2004.02.001","journal":"Journal of psychosomatic research","n_participants":null,"pmid":"15172204","source_url":"https://pubmed.ncbi.nlm.nih.gov/15172204/","study_design":null,"title":"Sleep and quantitative EEG in neurodegenerative disorders","title_match":false,"year":2004},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/serum-neuronal-exosomes-predict-and-differentiate-parkinson-s-disease-32273329","doi":"10.1136/jnnp-2019-322588","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":314,"pmid":"32273329","source_url":"https://pubmed.ncbi.nlm.nih.gov/32273329/","study_design":"cross-sectional","title":"Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism","title_match":false,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/new-evidence-on-the-management-of-lewy-body-dementia-31519472","doi":"10.1016/s1474-4422(19)30153-x","journal":"The Lancet. Neurology","n_participants":null,"pmid":"31519472","source_url":"https://pubmed.ncbi.nlm.nih.gov/31519472/","study_design":"meta-analysis","title":"New evidence on the management of Lewy body dementia","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neuroanatomy-and-pathology-of-sporadic-parkinson-s-disease-19230552","doi":"10.1007/978-3-540-79850-7","journal":"Advances in anatomy, embryology, and cell biology","n_participants":null,"pmid":"19230552","source_url":"https://pubmed.ncbi.nlm.nih.gov/19230552/","study_design":null,"title":"Neuroanatomy and pathology of sporadic Parkinson's disease","title_match":false,"year":2009},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/rapid-eye-movement-sleep-behaviour-disorder-and-neurodegenerative-16632313","doi":"10.1016/s1474-4422(06)70441-0","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16632313","source_url":"https://pubmed.ncbi.nlm.nih.gov/16632313/","study_design":null,"title":"Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases","title_match":false,"year":2006},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/biomarkers-of-conversion-to-synucleinopathy-in-isolated-rapid-eye-34302789","doi":"10.1016/s1474-4422(21)00176-9","journal":"The Lancet. Neurology","n_participants":null,"pmid":"34302789","source_url":"https://pubmed.ncbi.nlm.nih.gov/34302789/","study_design":null,"title":"Biomarkers of conversion to \u03b1-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder","title_match":true,"year":2021},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/validation-of-the-mayo-sleep-questionnaire-to-screen-for-rem-sleep-21349763","doi":"10.1016/j.sleep.2010.12.009","journal":"Sleep medicine","n_participants":176,"pmid":"21349763","source_url":"https://pubmed.ncbi.nlm.nih.gov/21349763/","study_design":null,"title":"Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort","title_match":false,"year":2011},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cholinesterase-inhibitors-new-roles-and-therapeutic-alternatives-15304240","doi":"10.1016/j.phrs.2003.11.017","journal":"Pharmacological research","n_participants":null,"pmid":"15304240","source_url":"https://pubmed.ncbi.nlm.nih.gov/15304240/","study_design":null,"title":"Cholinesterase inhibitors: new roles and therapeutic alternatives","title_match":false,"year":2004},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/dyrk1a-phosphorylates-alpha-synuclein-and-enhances-intracellular-16959772","doi":"10.1074/jbc.m606147200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16959772","source_url":"https://pubmed.ncbi.nlm.nih.gov/16959772/","study_design":null,"title":"Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation","title_match":true,"year":2006},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/the-down-syndrome-candidate-dual-specificity-tyrosine-phosphorylation-18938227","doi":"10.1016/j.neuroscience.2008.09.034","journal":"Neuroscience","n_participants":null,"pmid":"18938227","source_url":"https://pubmed.ncbi.nlm.nih.gov/18938227/","study_design":null,"title":"The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4","title_match":false,"year":2008},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/cholinesterase-inhibitor-therapy-stabilizes-symptoms-of-alzheimer-10850724","doi":"10.1097/00002093-200000001-00002","journal":"Alzheimer disease and associated disorders","n_participants":8000,"pmid":"10850724","source_url":"https://pubmed.ncbi.nlm.nih.gov/10850724/","study_design":null,"title":"Cholinesterase inhibitor therapy stabilizes symptoms of Alzheimer disease","title_match":false,"year":2000},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/tau-and-alpha-synuclein-inclusions-in-a-case-of-familial-15804056","doi":"10.1093/jnen/64.3.245","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"15804056","source_url":"https://pubmed.ncbi.nlm.nih.gov/15804056/","study_design":null,"title":"Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia","title_match":true,"year":2005},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-co-pathology-in-down-syndrome-associated-alzheimer-s-40528443","doi":"10.1002/alz.70342","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":270,"pmid":"40528443","source_url":"https://pubmed.ncbi.nlm.nih.gov/40528443/","study_design":null,"title":"Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/production-and-characterization-of-a-monospecific-antiserum-a128-to-2110208","doi":"10.1177/38.5.2110208","journal":"The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society","n_participants":null,"pmid":"2110208","source_url":"https://pubmed.ncbi.nlm.nih.gov/2110208/","study_design":null,"title":"Production and characterization of a monospecific antiserum (A128) to disaggregated Alzheimer paired helical filaments","title_match":false,"year":1990},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/the-many-neurofaces-of-prohibitins-1-and-2-crucial-for-the-healthy-37524128","doi":"10.1016/j.jchemneu.2023.102321","journal":"Journal of chemical neuroanatomy","n_participants":null,"pmid":"37524128","source_url":"https://pubmed.ncbi.nlm.nih.gov/37524128/","study_design":null,"title":"The many \"Neurofaces\" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/present-and-future-of-alzheimer-therapy-10961434","doi":"10.1007/978-3-7091-6781-6_24","journal":"Journal of neural transmission. Supplementum","n_participants":8000,"pmid":"10961434","source_url":"https://pubmed.ncbi.nlm.nih.gov/10961434/","study_design":null,"title":"Present and future of Alzheimer therapy","title_match":false,"year":2000},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/frequency-and-distribution-of-tunel-positive-neurons-in-brains-of-11837533","doi":"10.1046/j.1440-1789.2001.00411.x","journal":"Neuropathology : official journal of the Japanese Society of Neuropathology","n_participants":null,"pmid":"11837533","source_url":"https://pubmed.ncbi.nlm.nih.gov/11837533/","study_design":null,"title":"Frequency and distribution of TUNEL-positive neurons in brains of dementia with Lewy bodies: comparison with those in brains of Alzheimer's disease","title_match":true,"year":2001},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/ubiquitinated-tdp-43-in-frontotemporal-lobar-degeneration-and-17023659","doi":"10.1126/science.1134108","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"17023659","source_url":"https://pubmed.ncbi.nlm.nih.gov/17023659/","study_design":null,"title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","title_match":false,"year":2006},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/the-relevance-of-the-lewy-body-to-the-pathogenesis-of-idiopathic-2841426","doi":"10.1136/jnnp.51.6.745","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"2841426","source_url":"https://pubmed.ncbi.nlm.nih.gov/2841426/","study_design":null,"title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease","title_match":true,"year":1988},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/national-institute-on-aging-alzheimer-s-association-guidelines-for-22101365","doi":"10.1007/s00401-011-0910-3","journal":"Acta neuropathologica","n_participants":null,"pmid":"22101365","source_url":"https://pubmed.ncbi.nlm.nih.gov/22101365/","study_design":null,"title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach","title_match":false,"year":2012},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/ageing-and-parkinson-s-disease-substantia-nigra-regional-selectivity-1933245","doi":"10.1093/brain/114.5.2283","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"1933245","source_url":"https://pubmed.ncbi.nlm.nih.gov/1933245/","study_design":null,"title":"Ageing and Parkinson's disease: substantia nigra regional selectivity","title_match":false,"year":1991},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-in-filamentous-inclusions-of-lewy-bodies-from-9600990","doi":"10.1073/pnas.95.11.6469","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9600990","source_url":"https://pubmed.ncbi.nlm.nih.gov/9600990/","study_design":null,"title":"alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies","title_match":true,"year":1998},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/national-institute-on-aging-alzheimer-s-association-guidelines-for-22265587","doi":"10.1016/j.jalz.2011.10.007","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"22265587","source_url":"https://pubmed.ncbi.nlm.nih.gov/22265587/","study_design":null,"title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/mutations-in-lrrk2-cause-autosomal-dominant-parkinsonism-with-15541309","doi":"10.1016/j.neuron.2004.11.005","journal":"Neuron","n_participants":null,"pmid":"15541309","source_url":"https://pubmed.ncbi.nlm.nih.gov/15541309/","study_design":null,"title":"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology","title_match":false,"year":2004},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-new-mutation-e46k-of-alpha-synuclein-causes-parkinson-and-lewy-14755719","doi":"10.1002/ana.10795","journal":"Annals of neurology","n_participants":null,"pmid":"14755719","source_url":"https://pubmed.ncbi.nlm.nih.gov/14755719/","study_design":null,"title":"The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia","title_match":true,"year":2004},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/cloning-of-the-gene-containing-mutations-that-cause-park8-linked-15541308","doi":"10.1016/j.neuron.2004.10.023","journal":"Neuron","n_participants":null,"pmid":"15541308","source_url":"https://pubmed.ncbi.nlm.nih.gov/15541308/","study_design":null,"title":"Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease","title_match":false,"year":2004},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/epidemiology-of-parkinson-s-disease-28150045","doi":"10.1007/s00702-017-1686-y","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"28150045","source_url":"https://pubmed.ncbi.nlm.nih.gov/28150045/","study_design":null,"title":"Epidemiology of Parkinson's disease","title_match":false,"year":2017},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/familial-parkinson-disease-gene-product-parkin-is-a-ubiquitin-protein-10888878","doi":"10.1038/77060","journal":"Nature genetics","n_participants":null,"pmid":"10888878","source_url":"https://pubmed.ncbi.nlm.nih.gov/10888878/","study_design":null,"title":"Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase","title_match":false,"year":2000},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/exogenous-synuclein-fibrils-induce-lewy-body-pathology-leading-to-21982369","doi":"10.1016/j.neuron.2011.08.033","journal":"Neuron","n_participants":null,"pmid":"21982369","source_url":"https://pubmed.ncbi.nlm.nih.gov/21982369/","study_design":null,"title":"Exogenous \u03b1-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","title_match":true,"year":2011},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-many-faces-of-synuclein-from-structure-and-toxicity-to-23254192","doi":"10.1038/nrn3406","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"23254192","source_url":"https://pubmed.ncbi.nlm.nih.gov/23254192/","study_design":null,"title":"The many faces of \u03b1-synuclein: from structure and toxicity to therapeutic target","title_match":true,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/lewy-body-like-pathology-in-long-term-embryonic-nigral-transplants-in-18391962","doi":"10.1038/nm1747","journal":"Nature medicine","n_participants":null,"pmid":"18391962","source_url":"https://pubmed.ncbi.nlm.nih.gov/18391962/","study_design":null,"title":"Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease","title_match":true,"year":2008},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/microglia-in-neurodegenerative-diseases-mechanism-and-potential-37735487","doi":"10.1038/s41392-023-01588-0","journal":"Signal transduction and targeted therapy","n_participants":null,"pmid":"37735487","source_url":"https://pubmed.ncbi.nlm.nih.gov/37735487/","study_design":null,"title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/phosphorylation-of-ser-129-is-the-dominant-pathological-modification-16847063","doi":"10.1074/jbc.m600933200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16847063","source_url":"https://pubmed.ncbi.nlm.nih.gov/16847063/","study_design":null,"title":"Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease","title_match":true,"year":2006},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/inclusion-formation-and-neuronal-cell-death-through-neuron-to-neuron-19651612","doi":"10.1073/pnas.0903691106","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"19651612","source_url":"https://pubmed.ncbi.nlm.nih.gov/19651612/","study_design":null,"title":"Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein","title_match":true,"year":2009},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/accelerated-in-vitro-fibril-formation-by-a-mutant-alpha-synuclein-9809558","doi":"10.1038/3311","journal":"Nature medicine","n_participants":null,"pmid":"9809558","source_url":"https://pubmed.ncbi.nlm.nih.gov/9809558/","study_design":null,"title":"Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease","title_match":true,"year":1998},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/oxidative-damage-linked-to-neurodegeneration-by-selective-alpha-11062131","doi":"10.1126/science.290.5493.985","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"11062131","source_url":"https://pubmed.ncbi.nlm.nih.gov/11062131/","study_design":null,"title":"Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions","title_match":true,"year":2000},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/pathology-of-neurodegenerative-diseases-28062563","doi":"10.1101/cshperspect.a028035","journal":"Cold Spring Harbor perspectives in biology","n_participants":null,"pmid":"28062563","source_url":"https://pubmed.ncbi.nlm.nih.gov/28062563/","study_design":null,"title":"Pathology of Neurodegenerative Diseases","title_match":false,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/in-vivo-imaging-of-microglial-activation-with-11c-r-pk11195-pet-in-16182554","doi":"10.1016/j.nbd.2005.08.002","journal":"Neurobiology of disease","n_participants":null,"pmid":"16182554","source_url":"https://pubmed.ncbi.nlm.nih.gov/16182554/","study_design":"longitudinal study","title":"In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease","title_match":false,"year":2006},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/exogenous-alpha-synuclein-fibrils-seed-the-formation-of-lewy-body-19892735","doi":"10.1073/pnas.0908005106","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"19892735","source_url":"https://pubmed.ncbi.nlm.nih.gov/19892735/","study_design":null,"title":"Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells","title_match":true,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/filamentous-alpha-synuclein-inclusions-link-multiple-system-atrophy-9726379","doi":"10.1016/s0304-3940(98)00504-7","journal":"Neuroscience letters","n_participants":null,"pmid":"9726379","source_url":"https://pubmed.ncbi.nlm.nih.gov/9726379/","study_design":null,"title":"Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies","title_match":true,"year":1998},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/tdp-43-immunoreactivity-in-hippocampal-sclerosis-and-alzheimer-s-17469117","doi":"10.1002/ana.21154","journal":"Annals of neurology","n_participants":null,"pmid":"17469117","source_url":"https://pubmed.ncbi.nlm.nih.gov/17469117/","study_design":null,"title":"TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease","title_match":false,"year":2007},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/multi-organ-distribution-of-phosphorylated-alpha-synuclein-20306269","doi":"10.1007/s00401-010-0664-3","journal":"Acta neuropathologica","n_participants":92,"pmid":"20306269","source_url":"https://pubmed.ncbi.nlm.nih.gov/20306269/","study_design":null,"title":"Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders","title_match":true,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/prion-like-spreading-of-pathological-synuclein-in-brain-23466394","doi":"10.1093/brain/awt037","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"23466394","source_url":"https://pubmed.ncbi.nlm.nih.gov/23466394/","study_design":null,"title":"Prion-like spreading of pathological \u03b1-synuclein in brain","title_match":true,"year":2013},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/addition-of-exogenous-synuclein-preformed-fibrils-to-primary-neuronal-25122523","doi":"10.1038/nprot.2014.143","journal":"Nature protocols","n_participants":null,"pmid":"25122523","source_url":"https://pubmed.ncbi.nlm.nih.gov/25122523/","study_design":null,"title":"Addition of exogenous \u03b1-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous \u03b1-synuclein to Lewy body and Lewy neurite-like aggregates","title_match":true,"year":2014},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disease-concomitant-proteinopathies-are-prevalent-29878075","doi":"10.1093/brain/awy146","journal":"Brain : a journal of neurology","n_participants":247,"pmid":"29878075","source_url":"https://pubmed.ncbi.nlm.nih.gov/29878075/","study_design":null,"title":"Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated","title_match":false,"year":2018},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/rest-and-stress-resistance-in-ageing-and-alzheimer-s-disease-24670762","doi":"10.1038/nature13163","journal":"Nature","n_participants":null,"pmid":"24670762","source_url":"https://pubmed.ncbi.nlm.nih.gov/24670762/","study_design":null,"title":"REST and stress resistance in ageing and Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/oxidative-stress-and-the-pathogenesis-of-parkinson-s-disease-8959985","doi":"10.1212/wnl.47.6_suppl_3.161s","journal":"Neurology","n_participants":null,"pmid":"8959985","source_url":"https://pubmed.ncbi.nlm.nih.gov/8959985/","study_design":null,"title":"Oxidative stress and the pathogenesis of Parkinson's disease","title_match":false,"year":1996},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/s-nitrosylation-of-parkin-regulates-ubiquitination-and-compromises-15105460","doi":"10.1126/science.1093891","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"15105460","source_url":"https://pubmed.ncbi.nlm.nih.gov/15105460/","study_design":null,"title":"S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function","title_match":false,"year":2004},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/expression-of-nrf2-in-neurodegenerative-diseases-17204939","doi":"10.1097/nen.0b013e31802d6da9","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"17204939","source_url":"https://pubmed.ncbi.nlm.nih.gov/17204939/","study_design":null,"title":"Expression of Nrf2 in neurodegenerative diseases","title_match":false,"year":2007},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/unified-staging-system-for-lewy-body-disorders-correlation-with-19399512","doi":"10.1007/s00401-009-0538-8","journal":"Acta neuropathologica","n_participants":417,"pmid":"19399512","source_url":"https://pubmed.ncbi.nlm.nih.gov/19399512/","study_design":null,"title":"Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction","title_match":true,"year":2009},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-process-of-lewy-body-formation-rather-than-simply-synuclein-32075919","doi":"10.1073/pnas.1913904117","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"32075919","source_url":"https://pubmed.ncbi.nlm.nih.gov/32075919/","study_design":null,"title":"The process of Lewy body formation, rather than simply \u03b1-synuclein fibrillization, is one of the major drivers of neurodegeneration","title_match":true,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-clinicopathologic-study-of-100-cases-of-parkinson-s-disease-8431132","doi":"10.1001/archneur.1993.00540020018011","journal":"Archives of neurology","n_participants":null,"pmid":"8431132","source_url":"https://pubmed.ncbi.nlm.nih.gov/8431132/","study_design":null,"title":"A clinicopathologic study of 100 cases of Parkinson's disease","title_match":false,"year":1993},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/parkin-ubiquitinates-the-alpha-synuclein-interacting-protein-11590439","doi":"10.1038/nm1001-1144","journal":"Nature medicine","n_participants":null,"pmid":"11590439","source_url":"https://pubmed.ncbi.nlm.nih.gov/11590439/","study_design":null,"title":"Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease","title_match":true,"year":2001},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-neuropathology-of-traumatic-brain-injury-25702209","doi":"10.1016/b978-0-444-52892-6.00004-0","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"25702209","source_url":"https://pubmed.ncbi.nlm.nih.gov/25702209/","study_design":null,"title":"The neuropathology of traumatic brain injury","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/evidence-of-increased-oxidative-damage-in-both-sporadic-and-familial-9349552","doi":"10.1046/j.1471-4159.1997.69052064.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"9349552","source_url":"https://pubmed.ncbi.nlm.nih.gov/9349552/","study_design":null,"title":"Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis","title_match":false,"year":1997},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-fibrillogenesis-is-nucleation-dependent-implications-10391881","doi":"10.1074/jbc.274.28.19509","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"10391881","source_url":"https://pubmed.ncbi.nlm.nih.gov/10391881/","study_design":null,"title":"alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease","title_match":true,"year":1999},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/where-does-parkinson-disease-pathology-begin-in-the-brain-12030260","doi":"10.1093/jnen/61.5.413","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"12030260","source_url":"https://pubmed.ncbi.nlm.nih.gov/12030260/","study_design":null,"title":"Where does parkinson disease pathology begin in the brain?","title_match":false,"year":2002},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-alpha-synuclein-transgenic-mice-develop-neuronal-16399671","doi":"10.1523/jneurosci.4308-05.2006","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"16399671","source_url":"https://pubmed.ncbi.nlm.nih.gov/16399671/","study_design":null,"title":"Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death","title_match":true,"year":2006},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/improved-accuracy-of-clinical-diagnosis-of-lewy-body-parkinson-s-11673599","doi":"10.1212/wnl.57.8.1497","journal":"Neurology","n_participants":null,"pmid":"11673599","source_url":"https://pubmed.ncbi.nlm.nih.gov/11673599/","study_design":null,"title":"Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease","title_match":true,"year":2001},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/cellular-milieu-imparts-distinct-pathological-synuclein-strains-in-29743672","doi":"10.1038/s41586-018-0104-4","journal":"Nature","n_participants":null,"pmid":"29743672","source_url":"https://pubmed.ncbi.nlm.nih.gov/29743672/","study_design":null,"title":"Cellular milieu imparts distinct pathological \u03b1-synuclein strains in \u03b1-synucleinopathies","title_match":true,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/vesicle-permeabilization-by-protofibrillar-alpha-synuclein-11425308","doi":"10.1021/bi0102398","journal":"Biochemistry","n_participants":null,"pmid":"11425308","source_url":"https://pubmed.ncbi.nlm.nih.gov/11425308/","study_design":null,"title":"Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease","title_match":true,"year":2001},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/consensus-classification-of-posterior-cortical-atrophy-28259709","doi":"10.1016/j.jalz.2017.01.014","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"28259709","source_url":"https://pubmed.ncbi.nlm.nih.gov/28259709/","study_design":null,"title":"Consensus classification of posterior cortical atrophy","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/lewy-body-extracts-from-parkinson-disease-brains-trigger-synuclein-24243558","doi":"10.1002/ana.24066","journal":"Annals of neurology","n_participants":null,"pmid":"24243558","source_url":"https://pubmed.ncbi.nlm.nih.gov/24243558/","study_design":null,"title":"Lewy body extracts from Parkinson disease brains trigger \u03b1-synuclein pathology and neurodegeneration in mice and monkeys","title_match":true,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/proteasomal-function-is-impaired-in-substantia-nigra-in-parkinson-s-11137760","doi":"10.1016/s0304-3940(00)01701-8","journal":"Neuroscience letters","n_participants":null,"pmid":"11137760","source_url":"https://pubmed.ncbi.nlm.nih.gov/11137760/","study_design":null,"title":"Proteasomal function is impaired in substantia nigra in Parkinson's disease","title_match":false,"year":2001},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/beclin-1-gene-transfer-activates-autophagy-and-ameliorates-the-19864570","doi":"10.1523/jneurosci.4390-09.2009","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"19864570","source_url":"https://pubmed.ncbi.nlm.nih.gov/19864570/","study_design":null,"title":"Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases","title_match":true,"year":2009},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/relative-frequencies-of-alzheimer-disease-lewy-body-vascular-and-12468894","doi":"10.1097/00002093-200210000-00001","journal":"Alzheimer disease and associated disorders","n_participants":382,"pmid":"12468894","source_url":"https://pubmed.ncbi.nlm.nih.gov/12468894/","study_design":null,"title":"Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank","title_match":true,"year":2002},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-synaptic-pathology-of-alpha-synuclein-aggregation-in-dementia-20563819","doi":"10.1007/s00401-010-0711-0","journal":"Acta neuropathologica","n_participants":null,"pmid":"20563819","source_url":"https://pubmed.ncbi.nlm.nih.gov/20563819/","study_design":null,"title":"The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia","title_match":true,"year":2010},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/lewy-and-alzheimer-type-pathologies-in-parkinson-s-disease-dementia-21596773","doi":"10.1093/brain/awr031","journal":"Brain : a journal of neurology","n_participants":15,"pmid":"21596773","source_url":"https://pubmed.ncbi.nlm.nih.gov/21596773/","study_design":null,"title":"Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?","title_match":false,"year":2011},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/neuropathology-of-cognitively-normal-elderly-14656067","doi":"10.1093/jnen/62.11.1087","journal":"Journal of neuropathology and experimental neurology","n_participants":19,"pmid":"14656067","source_url":"https://pubmed.ncbi.nlm.nih.gov/14656067/","study_design":null,"title":"Neuropathology of cognitively normal elderly","title_match":false,"year":2003},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-link-between-the-gba-gene-and-parkinsonism-23079555","doi":"10.1016/s1474-4422(12)70190-4","journal":"The Lancet. Neurology","n_participants":null,"pmid":"23079555","source_url":"https://pubmed.ncbi.nlm.nih.gov/23079555/","study_design":null,"title":"The link between the GBA gene and parkinsonism","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/synergistic-interactions-between-abeta-tau-and-alpha-synuclein-20505094","doi":"10.1523/jneurosci.0490-10.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"20505094","source_url":"https://pubmed.ncbi.nlm.nih.gov/20505094/","study_design":null,"title":"Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline","title_match":true,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/etiology-and-pathogenesis-of-parkinson-s-disease-21626550","doi":"10.1002/mds.23732","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"21626550","source_url":"https://pubmed.ncbi.nlm.nih.gov/21626550/","study_design":null,"title":"Etiology and pathogenesis of Parkinson's disease","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/parkin-mediates-nonclassical-proteasomal-independent-ubiquitination-15728840","doi":"10.1523/jneurosci.4474-04.2005","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"15728840","source_url":"https://pubmed.ncbi.nlm.nih.gov/15728840/","study_design":null,"title":"Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation","title_match":true,"year":2005},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/beta-amyloid-peptides-enhance-alpha-synuclein-accumulation-and-11572944","doi":"10.1073/pnas.211412398","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"11572944","source_url":"https://pubmed.ncbi.nlm.nih.gov/11572944/","study_design":null,"title":"beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease","title_match":true,"year":2001},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/pathogenic-protein-seeding-in-alzheimer-disease-and-other-22028219","doi":"10.1002/ana.22615","journal":"Annals of neurology","n_participants":null,"pmid":"22028219","source_url":"https://pubmed.ncbi.nlm.nih.gov/22028219/","study_design":null,"title":"Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders","title_match":false,"year":2011},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/neuropathological-changes-in-essential-tremor-33-cases-compared-with-18025031","doi":"10.1093/brain/awm266","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"18025031","source_url":"https://pubmed.ncbi.nlm.nih.gov/18025031/","study_design":"case-control study","title":"Neuropathological changes in essential tremor: 33 cases compared with 21 controls","title_match":false,"year":2007},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/chaperone-mediated-autophagy-markers-in-parkinson-disease-brains-20697033","doi":"10.1001/archneurol.2010.198","journal":"Archives of neurology","n_participants":null,"pmid":"20697033","source_url":"https://pubmed.ncbi.nlm.nih.gov/20697033/","study_design":null,"title":"Chaperone-mediated autophagy markers in Parkinson disease brains","title_match":false,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/effects-of-alpha-synuclein-immunization-in-a-mouse-model-of-parkinson-15953415","doi":"10.1016/j.neuron.2005.05.010","journal":"Neuron","n_participants":null,"pmid":"15953415","source_url":"https://pubmed.ncbi.nlm.nih.gov/15953415/","study_design":null,"title":"Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease","title_match":true,"year":2005},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-cholinergic-system-and-parkinson-disease-20060022","doi":"10.1016/j.bbr.2009.12.048","journal":"Behavioural brain research","n_participants":null,"pmid":"20060022","source_url":"https://pubmed.ncbi.nlm.nih.gov/20060022/","study_design":null,"title":"The cholinergic system and Parkinson disease","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-genetic-epidemiology-of-neurodegenerative-disease-15931380","doi":"10.1172/jci24761","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"15931380","source_url":"https://pubmed.ncbi.nlm.nih.gov/15931380/","study_design":null,"title":"The genetic epidemiology of neurodegenerative disease","title_match":false,"year":2005},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/differential-neuropathological-alterations-in-transgenic-mice-12111846","doi":"10.1002/jnr.10231","journal":"Journal of neuroscience research","n_participants":null,"pmid":"12111846","source_url":"https://pubmed.ncbi.nlm.nih.gov/12111846/","study_design":null,"title":"Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters","title_match":true,"year":2002},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-a53t-alpha-synuclein-mutation-increases-iron-dependent-10934254","doi":"10.1523/jneurosci.20-16-06048.2000","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"10934254","source_url":"https://pubmed.ncbi.nlm.nih.gov/10934254/","study_design":null,"title":"The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity","title_match":true,"year":2000},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/stanley-fahn-lecture-2005-the-staging-procedure-for-the-inclusion-17078043","doi":"10.1002/mds.21065","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"17078043","source_url":"https://pubmed.ncbi.nlm.nih.gov/17078043/","study_design":"cross-sectional","title":"Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered","title_match":false,"year":2006},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/binding-of-alpha-synuclein-to-brain-vesicles-is-abolished-by-familial-9756856","doi":"10.1074/jbc.273.41.26292","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"9756856","source_url":"https://pubmed.ncbi.nlm.nih.gov/9756856/","study_design":null,"title":"Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation","title_match":true,"year":1998},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-neuropsychological-profile-of-alzheimer-disease-22474609","doi":"10.1101/cshperspect.a006171","journal":"Cold Spring Harbor perspectives in medicine","n_participants":null,"pmid":"22474609","source_url":"https://pubmed.ncbi.nlm.nih.gov/22474609/","study_design":null,"title":"The neuropsychological profile of Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/genetic-etiology-of-parkinson-disease-associated-with-mutations-in-20506312","doi":"10.1002/humu.21277","journal":"Human mutation","n_participants":null,"pmid":"20506312","source_url":"https://pubmed.ncbi.nlm.nih.gov/20506312/","study_design":null,"title":"Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update","title_match":false,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/tar-dna-binding-protein-43-in-neurodegenerative-disease-20234357","doi":"10.1038/nrneurol.2010.18","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"20234357","source_url":"https://pubmed.ncbi.nlm.nih.gov/20234357/","study_design":null,"title":"TAR DNA-binding protein 43 in neurodegenerative disease","title_match":false,"year":2010},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuropathology-in-mice-expressing-human-alpha-synuclein-10934251","doi":"10.1523/jneurosci.20-16-06021.2000","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"10934251","source_url":"https://pubmed.ncbi.nlm.nih.gov/10934251/","study_design":null,"title":"Neuropathology in mice expressing human alpha-synuclein","title_match":true,"year":2000},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/protein-nitration-in-parkinson-s-disease-9600227","doi":"10.1097/00005072-199804000-00006","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"9600227","source_url":"https://pubmed.ncbi.nlm.nih.gov/9600227/","study_design":null,"title":"Protein nitration in Parkinson's disease","title_match":false,"year":1998},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/chemistry-and-biochemistry-of-oxidative-stress-in-neurodegenerative-11375746","doi":"10.2174/0929867013372922","journal":"Current medicinal chemistry","n_participants":null,"pmid":"11375746","source_url":"https://pubmed.ncbi.nlm.nih.gov/11375746/","study_design":null,"title":"Chemistry and biochemistry of oxidative stress in neurodegenerative disease","title_match":false,"year":2001},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/genome-sequencing-analysis-identifies-new-loci-associated-with-lewy-33589841","doi":"10.1038/s41588-021-00785-3","journal":"Nature genetics","n_participants":null,"pmid":"33589841","source_url":"https://pubmed.ncbi.nlm.nih.gov/33589841/","study_design":null,"title":"Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture","title_match":true,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/loss-of-vps13c-function-in-autosomal-recessive-parkinsonism-causes-26942284","doi":"10.1016/j.ajhg.2016.01.014","journal":"American journal of human genetics","n_participants":null,"pmid":"26942284","source_url":"https://pubmed.ncbi.nlm.nih.gov/26942284/","study_design":null,"title":"Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy","title_match":false,"year":2016},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-spectrum-of-pathological-involvement-of-the-striatonigral-and-15509623","doi":"10.1093/brain/awh303","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"15509623","source_url":"https://pubmed.ncbi.nlm.nih.gov/15509623/","study_design":null,"title":"The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations","title_match":false,"year":2004},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-generalised-increase-in-protein-carbonyls-in-the-brain-in-parkinson-9282961","doi":"10.1046/j.1471-4159.1997.69031326.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"9282961","source_url":"https://pubmed.ncbi.nlm.nih.gov/9282961/","study_design":null,"title":"A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease","title_match":true,"year":1997},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-role-of-microglia-in-retinal-neurodegeneration-alzheimer-s-28729832","doi":"10.3389/fnagi.2017.00214","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"28729832","source_url":"https://pubmed.ncbi.nlm.nih.gov/28729832/","study_design":null,"title":"The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma","title_match":false,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-lewy-body-in-parkinson-s-disease-molecules-implicated-in-the-18018486","doi":"10.1111/j.1440-1789.2007.00803.x","journal":"Neuropathology : official journal of the Japanese Society of Neuropathology","n_participants":null,"pmid":"18018486","source_url":"https://pubmed.ncbi.nlm.nih.gov/18018486/","study_design":null,"title":"The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates","title_match":true,"year":2007},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/axonal-alpha-synuclein-aggregates-herald-centripetal-degeneration-of-18079166","doi":"10.1093/brain/awm302","journal":"Brain : a journal of neurology","n_participants":20,"pmid":"18079166","source_url":"https://pubmed.ncbi.nlm.nih.gov/18079166/","study_design":null,"title":"Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease","title_match":true,"year":2008},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/mechanisms-of-parkinson-s-disease-linked-to-pathological-alpha-17015225","doi":"10.1016/j.neuron.2006.09.026","journal":"Neuron","n_participants":null,"pmid":"17015225","source_url":"https://pubmed.ncbi.nlm.nih.gov/17015225/","study_design":null,"title":"Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery","title_match":true,"year":2006},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuropathology-provides-clues-to-the-pathophysiology-of-gaucher-15234332","doi":"10.1016/j.ymgme.2004.04.011","journal":"Molecular genetics and metabolism","n_participants":null,"pmid":"15234332","source_url":"https://pubmed.ncbi.nlm.nih.gov/15234332/","study_design":null,"title":"Neuropathology provides clues to the pathophysiology of Gaucher disease","title_match":false,"year":2004},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/passive-immunization-reduces-behavioral-and-neuropathological-21559417","doi":"10.1371/journal.pone.0019338","journal":"PloS one","n_participants":null,"pmid":"21559417","source_url":"https://pubmed.ncbi.nlm.nih.gov/21559417/","study_design":null,"title":"Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease","title_match":true,"year":2011},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/accuracy-of-clinical-diagnosis-in-parkinsonism-a-prospective-study-1913360","doi":"10.1017/s0317167100031814","journal":"The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques","n_participants":null,"pmid":"1913360","source_url":"https://pubmed.ncbi.nlm.nih.gov/1913360/","study_design":null,"title":"Accuracy of clinical diagnosis in parkinsonism--a prospective study","title_match":false,"year":1991},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/transmission-of-multiple-system-atrophy-prions-to-transgenic-mice-24218576","doi":"10.1073/pnas.1318268110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"24218576","source_url":"https://pubmed.ncbi.nlm.nih.gov/24218576/","study_design":null,"title":"Transmission of multiple system atrophy prions to transgenic mice","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/clearance-of-alpha-synuclein-oligomeric-intermediates-via-the-14985429","doi":"10.1523/jneurosci.3809-03.2004","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"14985429","source_url":"https://pubmed.ncbi.nlm.nih.gov/14985429/","study_design":null,"title":"Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway","title_match":true,"year":2004},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-role-of-zinc-copper-manganese-and-iron-in-neurodegenerative-31377220","doi":"10.1016/j.neuro.2019.07.007","journal":"Neurotoxicology","n_participants":null,"pmid":"31377220","source_url":"https://pubmed.ncbi.nlm.nih.gov/31377220/","study_design":null,"title":"The role of zinc, copper, manganese and iron in neurodegenerative diseases","title_match":false,"year":2019},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-role-of-tdp-43-propagation-in-neurodegenerative-diseases-33051572","doi":"10.1038/s12276-020-00513-7","journal":"Experimental & molecular medicine","n_participants":null,"pmid":"33051572","source_url":"https://pubmed.ncbi.nlm.nih.gov/33051572/","study_design":null,"title":"The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/clinical-correlations-with-lewy-body-pathology-in-lrrk2-related-25401511","doi":"10.1001/jamaneurol.2014.2704","journal":"JAMA neurology","n_participants":null,"pmid":"25401511","source_url":"https://pubmed.ncbi.nlm.nih.gov/25401511/","study_design":null,"title":"Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease","title_match":true,"year":2015},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/interactions-of-pathological-proteins-in-neurodegenerative-diseases-28401333","doi":"10.1007/s00401-017-1709-7","journal":"Acta neuropathologica","n_participants":null,"pmid":"28401333","source_url":"https://pubmed.ncbi.nlm.nih.gov/28401333/","study_design":null,"title":"Interactions of pathological proteins in neurodegenerative diseases","title_match":false,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/lewy-bodies-and-parkinsonism-in-families-with-parkin-mutations-11558785","doi":"10.1002/ana.1132","journal":"Annals of neurology","n_participants":38,"pmid":"11558785","source_url":"https://pubmed.ncbi.nlm.nih.gov/11558785/","study_design":null,"title":"Lewy bodies and parkinsonism in families with parkin mutations","title_match":true,"year":2001},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-lewy-body-in-parkinson-s-disease-and-related-neurodegenerative-22622968","doi":"10.1007/s12035-012-8280-y","journal":"Molecular neurobiology","n_participants":null,"pmid":"22622968","source_url":"https://pubmed.ncbi.nlm.nih.gov/22622968/","study_design":null,"title":"The Lewy body in Parkinson's disease and related neurodegenerative disorders","title_match":true,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/intrastriatal-injection-of-pre-formed-mouse-synuclein-fibrils-into-26093169","doi":"10.1016/j.nbd.2015.06.003","journal":"Neurobiology of disease","n_participants":null,"pmid":"26093169","source_url":"https://pubmed.ncbi.nlm.nih.gov/26093169/","study_design":null,"title":"Intrastriatal injection of pre-formed mouse \u03b1-synuclein fibrils into rats triggers \u03b1-synuclein pathology and bilateral nigrostriatal degeneration","title_match":true,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/axon-pathology-in-parkinson-s-disease-and-lewy-body-dementia-10557341","doi":"10.1073/pnas.96.23.13450","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10557341","source_url":"https://pubmed.ncbi.nlm.nih.gov/10557341/","study_design":null,"title":"Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein","title_match":true,"year":1999},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/oxidative-stress-as-a-cause-of-nigral-cell-death-in-parkinson-s-1510385","doi":"10.1002/ana.410320714","journal":"Annals of neurology","n_participants":null,"pmid":"1510385","source_url":"https://pubmed.ncbi.nlm.nih.gov/1510385/","study_design":null,"title":"Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group","title_match":true,"year":1992},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-versus-dementia-with-lewy-bodies-cerebral-11558792","doi":"10.1002/ana.1133","journal":"Annals of neurology","n_participants":53,"pmid":"11558792","source_url":"https://pubmed.ncbi.nlm.nih.gov/11558792/","study_design":null,"title":"Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation","title_match":true,"year":2001},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/a-clinico-pathological-study-of-subtypes-in-parkinson-s-disease-19759203","doi":"10.1093/brain/awp234","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"19759203","source_url":"https://pubmed.ncbi.nlm.nih.gov/19759203/","study_design":"systematic review","title":"A clinico-pathological study of subtypes in Parkinson's disease","title_match":false,"year":2009},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/animal-models-of-parkinson-s-disease-an-empirical-comparison-with-the-9013391","doi":"10.1007/bf01291788","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"9013391","source_url":"https://pubmed.ncbi.nlm.nih.gov/9013391/","study_design":null,"title":"Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man","title_match":false,"year":1996},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/profiles-of-extracellular-mirna-in-cerebrospinal-fluid-and-serum-from-24797360","doi":"10.1371/journal.pone.0094839","journal":"PloS one","n_participants":69,"pmid":"24797360","source_url":"https://pubmed.ncbi.nlm.nih.gov/24797360/","study_design":null,"title":"Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology","title_match":false,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/mitochondrial-dysfunction-associated-with-increased-oxidative-stress-23039195","doi":"10.1186/1756-6606-5-35","journal":"Molecular brain","n_participants":null,"pmid":"23039195","source_url":"https://pubmed.ncbi.nlm.nih.gov/23039195/","study_design":null,"title":"Mitochondrial dysfunction associated with increased oxidative stress and \u03b1-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue","title_match":true,"year":2012},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/genome-wide-association-meta-analysis-of-neuropathologic-features-of-25188341","doi":"10.1371/journal.pgen.1004606","journal":"PLoS genetics","n_participants":null,"pmid":"25188341","source_url":"https://pubmed.ncbi.nlm.nih.gov/25188341/","study_design":null,"title":"Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias","title_match":false,"year":2014},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/increased-level-of-active-gsk-3beta-in-alzheimer-s-disease-and-17239007","doi":"10.1111/j.1365-2990.2006.00795.x","journal":"Neuropathology and applied neurobiology","n_participants":null,"pmid":"17239007","source_url":"https://pubmed.ncbi.nlm.nih.gov/17239007/","study_design":null,"title":"Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration","title_match":false,"year":2007},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/clinical-correlates-of-selective-pathology-in-the-amygdala-of-12390970","doi":"10.1093/brain/awf251","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"12390970","source_url":"https://pubmed.ncbi.nlm.nih.gov/12390970/","study_design":null,"title":"Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease","title_match":false,"year":2002},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-with-amygdala-lewy-bodies-a-distinct-form-of-alpha-16825955","doi":"10.1097/01.jnen.0000225908.90052.07","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"16825955","source_url":"https://pubmed.ncbi.nlm.nih.gov/16825955/","study_design":null,"title":"Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy","title_match":true,"year":2006},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/colocalization-of-tau-and-alpha-synuclein-epitopes-in-lewy-bodies-12722831","doi":"10.1093/jnen/62.4.389","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"12722831","source_url":"https://pubmed.ncbi.nlm.nih.gov/12722831/","study_design":null,"title":"Colocalization of tau and alpha-synuclein epitopes in Lewy bodies","title_match":true,"year":2003},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/nucleus-basalis-of-meynert-revisited-anatomy-history-and-differential-25633602","doi":"10.1007/s00401-015-1392-5","journal":"Acta neuropathologica","n_participants":null,"pmid":"25633602","source_url":"https://pubmed.ncbi.nlm.nih.gov/25633602/","study_design":null,"title":"Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease","title_match":false,"year":2015},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/prevalence-of-mixed-pathologies-in-the-aging-brain-25419243","doi":"10.1186/s13195-014-0082-1","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"25419243","source_url":"https://pubmed.ncbi.nlm.nih.gov/25419243/","study_design":null,"title":"Prevalence of mixed pathologies in the aging brain","title_match":false,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/transgenic-mice-carrying-a-human-mutant-superoxide-dismutase-8610185","doi":"10.1073/pnas.93.7.3155","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8610185","source_url":"https://pubmed.ncbi.nlm.nih.gov/8610185/","study_design":null,"title":"Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions","title_match":false,"year":1996},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-progression-of-pathology-in-longitudinally-followed-patients-with-18231798","doi":"10.1007/s00401-008-0344-8","journal":"Acta neuropathologica","n_participants":null,"pmid":"18231798","source_url":"https://pubmed.ncbi.nlm.nih.gov/18231798/","study_design":null,"title":"The progression of pathology in longitudinally followed patients with Parkinson's disease","title_match":false,"year":2008},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/abnormal-accumulation-of-nacp-alpha-synuclein-in-neurodegenerative-9466562","doi":null,"journal":"The American journal of pathology","n_participants":null,"pmid":"9466562","source_url":"https://pubmed.ncbi.nlm.nih.gov/9466562/","study_design":null,"title":"Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders","title_match":true,"year":1998},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/selective-molecular-alterations-in-the-autophagy-pathway-in-patients-20174468","doi":"10.1371/journal.pone.0009313","journal":"PloS one","n_participants":null,"pmid":"20174468","source_url":"https://pubmed.ncbi.nlm.nih.gov/20174468/","study_design":null,"title":"Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy","title_match":true,"year":2010},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/modeling-parkinson-s-disease-with-the-alpha-synuclein-protein-32390826","doi":"10.3389/fphar.2020.00356","journal":"Frontiers in pharmacology","n_participants":null,"pmid":"32390826","source_url":"https://pubmed.ncbi.nlm.nih.gov/32390826/","study_design":null,"title":"Modeling Parkinson's Disease With the Alpha-Synuclein Protein","title_match":true,"year":2020},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/pathological-changes-in-the-nucleus-of-meynert-in-alzheimer-s-and-6854353","doi":"10.1016/0022-510x(83)90045-x","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"6854353","source_url":"https://pubmed.ncbi.nlm.nih.gov/6854353/","study_design":null,"title":"Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases","title_match":false,"year":1983},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/nonamnestic-mild-cognitive-impairment-progresses-to-dementia-with-24212390","doi":"10.1212/01.wnl.0000436942.55281.47","journal":"Neurology","n_participants":337,"pmid":"24212390","source_url":"https://pubmed.ncbi.nlm.nih.gov/24212390/","study_design":null,"title":"Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies","title_match":true,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/cognitive-status-correlates-with-white-matter-alteration-in-parkinson-21495116","doi":"10.1002/hbm.21245","journal":"Human brain mapping","n_participants":32,"pmid":"21495116","source_url":"https://pubmed.ncbi.nlm.nih.gov/21495116/","study_design":null,"title":"Cognitive status correlates with white matter alteration in Parkinson's disease","title_match":false,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neuropathologic-alterations-in-mild-cognitive-impairment-a-review-20061641","doi":"10.3233/jad-2010-1220","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20061641","source_url":"https://pubmed.ncbi.nlm.nih.gov/20061641/","study_design":null,"title":"Neuropathologic alterations in mild cognitive impairment: a review","title_match":false,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-a-systematic-review-17851192","doi":"10.3233/jad-2007-12104","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"17851192","source_url":"https://pubmed.ncbi.nlm.nih.gov/17851192/","study_design":null,"title":"Mild cognitive impairment: a systematic review","title_match":false,"year":2007},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/impact-of-molecular-imaging-on-the-diagnostic-process-in-a-memory-23164552","doi":"10.1016/j.jalz.2012.07.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":39,"pmid":"23164552","source_url":"https://pubmed.ncbi.nlm.nih.gov/23164552/","study_design":null,"title":"Impact of molecular imaging on the diagnostic process in a memory clinic","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/sleep-disorders-in-aging-and-dementia-20191256","doi":"10.1007/s12603-010-0052-7","journal":"The journal of nutrition, health & aging","n_participants":null,"pmid":"20191256","source_url":"https://pubmed.ncbi.nlm.nih.gov/20191256/","study_design":null,"title":"Sleep disorders in aging and dementia","title_match":false,"year":2010},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/choroid-plexus-volume-is-associated-with-levels-of-csf-proteins-32107064","doi":"10.1016/j.neurobiolaging.2020.01.005","journal":"Neurobiology of aging","n_participants":509,"pmid":"32107064","source_url":"https://pubmed.ncbi.nlm.nih.gov/32107064/","study_design":null,"title":"Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease","title_match":false,"year":2020},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-relationship-between-anxiety-and-alzheimer-s-disease-33981954","doi":"10.3233/adr-210294","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"33981954","source_url":"https://pubmed.ncbi.nlm.nih.gov/33981954/","study_design":null,"title":"The Relationship Between Anxiety and Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/neural-biomarker-diagnosis-and-prediction-to-mild-cognitive-36765411","doi":"10.1186/s13195-023-01181-1","journal":"Alzheimer's research & therapy","n_participants":890,"pmid":"36765411","source_url":"https://pubmed.ncbi.nlm.nih.gov/36765411/","study_design":null,"title":"Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer's disease using EEG technology","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-of-lewy-body-associated-disorders-20922808","doi":"10.1002/mds.23393","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"20922808","source_url":"https://pubmed.ncbi.nlm.nih.gov/20922808/","study_design":"longitudinal study","title":"Amyloid imaging of Lewy body-associated disorders","title_match":true,"year":2010},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/quantitative-electroencephalogram-utility-in-predicting-conversion-of-25129239","doi":"10.1016/j.neurobiolaging.2014.07.009","journal":"Neurobiology of aging","n_participants":20,"pmid":"25129239","source_url":"https://pubmed.ncbi.nlm.nih.gov/25129239/","study_design":null,"title":"Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies","title_match":true,"year":2015},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/interleukin-1-mediates-alzheimer-and-lewy-body-pathologies-16542445","doi":"10.1186/1742-2094-3-5","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"16542445","source_url":"https://pubmed.ncbi.nlm.nih.gov/16542445/","study_design":null,"title":"Interleukin-1 mediates Alzheimer and Lewy body pathologies","title_match":true,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/trem2-deficiency-aggravates-synuclein-induced-neurodegeneration-and-31370707","doi":"10.1096/fj.201900992r","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"31370707","source_url":"https://pubmed.ncbi.nlm.nih.gov/31370707/","study_design":null,"title":"TREM2 deficiency aggravates \u03b1-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models","title_match":true,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/novel-presenilin-1-mutation-s170f-causing-alzheimer-disease-with-lewy-16344340","doi":"10.1001/archneur.62.12.1821","journal":"Archives of neurology","n_participants":null,"pmid":"16344340","source_url":"https://pubmed.ncbi.nlm.nih.gov/16344340/","study_design":null,"title":"Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life","title_match":true,"year":2005},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/soluble-trem2-is-elevated-in-parkinson-s-disease-subgroups-with-32065223","doi":"10.1093/brain/awaa021","journal":"Brain : a journal of neurology","n_participants":165,"pmid":"32065223","source_url":"https://pubmed.ncbi.nlm.nih.gov/32065223/","study_design":"cross-sectional","title":"Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/decoding-parkinson-s-disease-the-interplay-of-cell-death-pathways-40712453","doi":"10.1016/j.redox.2025.103787","journal":"Redox biology","n_participants":null,"pmid":"40712453","source_url":"https://pubmed.ncbi.nlm.nih.gov/40712453/","study_design":null,"title":"Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovations","title_match":false,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-for-parkinson-disease-diagnosis-and-21400565","doi":"10.1002/ana.22311","journal":"Annals of neurology","n_participants":null,"pmid":"21400565","source_url":"https://pubmed.ncbi.nlm.nih.gov/21400565/","study_design":"cross-sectional","title":"Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression","title_match":false,"year":2011},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/identification-of-novel-csf-biomarkers-for-neurodegeneration-and-26627638","doi":"10.1186/s13024-015-0059-y","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"26627638","source_url":"https://pubmed.ncbi.nlm.nih.gov/26627638/","study_design":null,"title":"Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay","title_match":false,"year":2015},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-and-csf-serpins-in-alzheimer-disease-and-dementia-with-lewy-17761554","doi":"10.1212/01.wnl.0000271077.82508.a0","journal":"Neurology","n_participants":258,"pmid":"17761554","source_url":"https://pubmed.ncbi.nlm.nih.gov/17761554/","study_design":null,"title":"Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies","title_match":true,"year":2007},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/csf-tau-and-amyloid-predict-cerebral-synucleinopathy-in-autopsied-29467305","doi":"10.1212/wnl.0000000000005166","journal":"Neurology","n_participants":24,"pmid":"29467305","source_url":"https://pubmed.ncbi.nlm.nih.gov/29467305/","study_design":null,"title":"CSF tau and \u03b2-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders","title_match":true,"year":2018},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau181-and-p-tau231-concentrations-with-34807233","doi":"10.1001/jamaneurol.2021.4222","journal":"JAMA neurology","n_participants":371,"pmid":"34807233","source_url":"https://pubmed.ncbi.nlm.nih.gov/34807233/","study_design":"cohort study","title":"Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies","title_match":true,"year":2022},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-markers-in-dementia-with-lewy-bodies-compared-12975286","doi":"10.1001/archneur.60.9.1218","journal":"Archives of neurology","n_participants":33,"pmid":"12975286","source_url":"https://pubmed.ncbi.nlm.nih.gov/12975286/","study_design":null,"title":"Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease","title_match":true,"year":2003},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cognitive-profile-and-markers-of-alzheimer-disease-type-pathology-in-33593865","doi":"10.1212/wnl.0000000000011699","journal":"Neurology","n_participants":38,"pmid":"33593865","source_url":"https://pubmed.ncbi.nlm.nih.gov/33593865/","study_design":null,"title":"Cognitive Profile and Markers of Alzheimer Disease-Type Pathology in Patients With Lewy Body Dementias","title_match":true,"year":2021},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/neurogranin-as-a-novel-biomarker-in-alzheimer-s-disease-32926148","doi":"10.1093/labmed/lmaa062","journal":"Laboratory medicine","n_participants":null,"pmid":"32926148","source_url":"https://pubmed.ncbi.nlm.nih.gov/32926148/","study_design":null,"title":"Neurogranin as a Novel Biomarker in Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-synuclein-contributes-to-the-differential-29604263","doi":"10.1016/j.jalz.2018.02.015","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":367,"pmid":"29604263","source_url":"https://pubmed.ncbi.nlm.nih.gov/29604263/","study_design":null,"title":"Cerebrospinal fluid \u03b1-synuclein contributes to the differential diagnosis of Alzheimer's disease","title_match":true,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-alzheimer-biomarkers-can-be-useful-for-29321140","doi":"10.1136/jnnp-2017-316385","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":57,"pmid":"29321140","source_url":"https://pubmed.ncbi.nlm.nih.gov/29321140/","study_design":null,"title":"Cerebrospinal fluid Alzheimer biomarkers can be useful for discriminating dementia with Lewy bodies from Alzheimer's disease at the prodromal stage","title_match":true,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/correlations-of-csf-tau-and-amyloid-levels-with-alzheimer-pathology-22911491","doi":"10.1002/gps.3881","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"22911491","source_url":"https://pubmed.ncbi.nlm.nih.gov/22911491/","study_design":null,"title":"Correlations of CSF tau and amyloid levels with Alzheimer pathology in neuropathologically verified dementia with Lewy bodies","title_match":true,"year":2013},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-of-alzheimer-disease-in-patients-with-concomitant-36041863","doi":"10.1212/wnl.0000000000201202","journal":"Neurology","n_participants":61,"pmid":"36041863","source_url":"https://pubmed.ncbi.nlm.nih.gov/36041863/","study_design":null,"title":"CSF Biomarkers of Alzheimer Disease in Patients With Concomitant \u03b1-Synuclein Pathology","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/systematic-review-on-saliva-biomarkers-in-patients-diagnosed-with-35885007","doi":"10.3390/biomedicines10071702","journal":"Biomedicines","n_participants":null,"pmid":"35885007","source_url":"https://pubmed.ncbi.nlm.nih.gov/35885007/","study_design":"case-control study","title":"Systematic Review on Saliva Biomarkers in Patients Diagnosed with Morbus Alzheimer and Morbus Parkinson","title_match":false,"year":2022},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/in-vivo-prevalence-of-alzheimer-biomarkers-in-dementia-with-lewy-31311013","doi":"10.1159/000500567","journal":"Dementia and geriatric cognitive disorders","n_participants":38,"pmid":"31311013","source_url":"https://pubmed.ncbi.nlm.nih.gov/31311013/","study_design":null,"title":"In vivo Prevalence of Alzheimer Biomarkers in Dementia with Lewy Bodies","title_match":true,"year":2019},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/clinical-relevance-of-sup-18-sup-f-florbetaben-and-sup-18-sup-f-fdg-33652938","doi":"10.3390/molecules26051282","journal":"Molecules (Basel, Switzerland)","n_participants":40,"pmid":"33652938","source_url":"https://pubmed.ncbi.nlm.nih.gov/33652938/","study_design":null,"title":"Clinical Relevance of [18F]Florbetaben and [18F]FDG PET/CT Imaging on the Management of Patients with Dementia","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-profile-and-markers-of-alzheimer-disease-38519009","doi":"10.1016/j.brainres.2024.148881","journal":"Brain research","n_participants":36,"pmid":"38519009","source_url":"https://pubmed.ncbi.nlm.nih.gov/38519009/","study_design":null,"title":"Neuropsychiatric symptoms profile and markers of Alzheimer disease-type pathology in patients with Lewy body dementias","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/narrative-organization-deficit-in-lewy-body-disorders-is-related-to-28228714","doi":"10.3389/fnins.2017.00053","journal":"Frontiers in neuroscience","n_participants":30,"pmid":"28228714","source_url":"https://pubmed.ncbi.nlm.nih.gov/28228714/","study_design":null,"title":"Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology","title_match":true,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/synuclein-seed-amplifications-assay-in-a-cohort-with-cognitive-40921019","doi":"10.1212/wnl.0000000000214040","journal":"Neurology","n_participants":337,"pmid":"40921019","source_url":"https://pubmed.ncbi.nlm.nih.gov/40921019/","study_design":"cohort study","title":"\u03b1-Synuclein Seed Amplifications Assay in a Cohort With Cognitive Impairment: Performance and Interactions With CSF and Plasma Biomarkers","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/csf-synuclein-seed-amplification-assays-and-alzheimer-disease-41248454","doi":"10.1212/wnl.0000000000214346","journal":"Neurology","n_participants":null,"pmid":"41248454","source_url":"https://pubmed.ncbi.nlm.nih.gov/41248454/","study_design":"cohort study","title":"CSF \u03b1-Synuclein Seed Amplification Assays and Alzheimer Disease Biomarkers in Dementia With Lewy Bodies: Presentation and Progression","title_match":true,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-phase-2b-randomized-clinical-trial-of-the-oral-p38-inhibitor-9c23dcf2","doi":"10.21203/rs.3.rs-10623740/v1","journal":"Research Square","n_participants":159,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10623740/v1","study_design":null,"title":"A Phase 2b randomized clinical trial of the oral p38\u03b1 inhibitor neflamapimod in dementia with Lewy bodies (DLB)","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/antemortem-synuclein-levels-from-neuron-derived-extracellular-cddcbabb","doi":"10.64898/2026.08.03.26359636","journal":"medRxiv","n_participants":1304,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.03.26359636","study_design":null,"title":"Antemortem \u03b1-Synuclein levels from neuron-derived extracellular vesicles identify Lewy Body pathology in Parkinson\u2019s Disease and Alzheimer Disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/routine-implementation-of-synuclein-seed-amplification-assays-reveals-b20dbc37","doi":"10.64898/2026.04.21.26351389","journal":"medRxiv","n_participants":398,"pmid":null,"source_url":"https://doi.org/10.64898/2026.04.21.26351389","study_design":null,"title":"Routine implementation of \u03b1-synuclein Seed Amplification Assays reveals high diagnostic performance and the limited value of Alzheimer disease fluid biomarkers for detecting \u03b1-synuclein co-pathology","title_match":true,"year":2026},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/antiamyloid-treatment-for-dementia-concerns-outweigh-hopes-40511512","doi":"10.1097/yco.0000000000001021","journal":"Current opinion in psychiatry","n_participants":null,"pmid":"40511512","source_url":"https://pubmed.ncbi.nlm.nih.gov/40511512/","study_design":null,"title":"Antiamyloid treatment for dementia: concerns outweigh hopes","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cognitive-differences-in-dementia-patients-with-autopsy-verified-ad-15985574","doi":"10.1212/01.wnl.0000165987.89198.65","journal":"Neurology","n_participants":135,"pmid":"15985574","source_url":"https://pubmed.ncbi.nlm.nih.gov/15985574/","study_design":null,"title":"Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both","title_match":true,"year":2005},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/cognitive-decline-is-faster-in-lewy-body-variant-than-in-alzheimer-s-9710002","doi":"10.1212/wnl.51.2.351","journal":"Neurology","n_participants":null,"pmid":"9710002","source_url":"https://pubmed.ncbi.nlm.nih.gov/9710002/","study_design":"longitudinal study","title":"Cognitive decline is faster in Lewy body variant than in Alzheimer's disease","title_match":true,"year":1998},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/perception-attention-and-working-memory-are-disproportionately-11160462","doi":"10.1136/jnnp.70.2.157","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"11160462","source_url":"https://pubmed.ncbi.nlm.nih.gov/11160462/","study_design":null,"title":"Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer's disease","title_match":true,"year":2001},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/cholinesterase-inhibitors-for-dementia-with-lewy-bodies-parkinson-s-22419314","doi":"10.1002/14651858.cd006504.pub2","journal":"The Cochrane database of systematic reviews","n_participants":1236,"pmid":"22419314","source_url":"https://pubmed.ncbi.nlm.nih.gov/22419314/","study_design":null,"title":"Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease","title_match":true,"year":2012},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/efficacy-and-safety-of-cholinesterase-inhibitors-and-memantine-in-24828899","doi":"10.1136/jnnp-2014-307659","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"24828899","source_url":"https://pubmed.ncbi.nlm.nih.gov/24828899/","study_design":"meta-analysis","title":"Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis","title_match":true,"year":2015},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-alpha-synuclein-in-neurodegenerative-disorders-a-19022350","doi":"10.1016/j.neulet.2008.11.015","journal":"Neuroscience letters","n_participants":15,"pmid":"19022350","source_url":"https://pubmed.ncbi.nlm.nih.gov/19022350/","study_design":null,"title":"Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?","title_match":true,"year":2009},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/neuropsychological-tests-of-simple-application-for-diagnosing-dementia-7611936","doi":"10.1590/s0004-282x1994000400001","journal":"Arquivos de neuro-psiquiatria","n_participants":null,"pmid":"7611936","source_url":"https://pubmed.ncbi.nlm.nih.gov/7611936/","study_design":null,"title":"[Neuropsychological tests of simple application for diagnosing dementia]","title_match":false,"year":1994},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cognitive-decline-correlates-with-neuropathological-stage-in-16814807","doi":"10.1016/j.jns.2006.05.011","journal":"Journal of the neurological sciences","n_participants":88,"pmid":"16814807","source_url":"https://pubmed.ncbi.nlm.nih.gov/16814807/","study_design":null,"title":"Cognitive decline correlates with neuropathological stage in Parkinson's disease","title_match":false,"year":2006},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/concomitant-ad-pathology-affects-clinical-manifestation-and-survival-27794030","doi":"10.1136/jnnp-2016-313775","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":111,"pmid":"27794030","source_url":"https://pubmed.ncbi.nlm.nih.gov/27794030/","study_design":null,"title":"Concomitant AD pathology affects clinical manifestation and survival in dementia with Lewy bodies","title_match":true,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/a-randomized-cross-over-study-of-a-traditional-japanese-medicine-19079814","doi":"10.1017/s146114570800970x","journal":"The international journal of neuropsychopharmacology","n_participants":106,"pmid":"19079814","source_url":"https://pubmed.ncbi.nlm.nih.gov/19079814/","study_design":null,"title":"A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia","title_match":false,"year":2009},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/atrophy-of-the-cholinergic-basal-forebrain-in-dementia-with-lewy-25059393","doi":"10.1007/s00415-014-7439-z","journal":"Journal of neurology","n_participants":null,"pmid":"25059393","source_url":"https://pubmed.ncbi.nlm.nih.gov/25059393/","study_design":null,"title":"Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer's disease dementia","title_match":true,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/early-and-widespread-cholinergic-losses-differentiate-dementia-with-12365882","doi":"10.1001/archpsyc.59.10.946","journal":"Archives of general psychiatry","n_participants":89,"pmid":"12365882","source_url":"https://pubmed.ncbi.nlm.nih.gov/12365882/","study_design":null,"title":"Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease","title_match":true,"year":2002},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/a-comparison-of-99m-tc-hmpao-spet-changes-in-dementia-with-lewy-11976799","doi":"10.1007/s00259-002-0778-5","journal":"European journal of nuclear medicine and molecular imaging","n_participants":null,"pmid":"11976799","source_url":"https://pubmed.ncbi.nlm.nih.gov/11976799/","study_design":null,"title":"A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping","title_match":true,"year":2002},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/gba-and-apoe-impact-cognitive-decline-in-parkinson-s-disease-a-10-35106798","doi":"10.1002/mds.28932","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":281,"pmid":"35106798","source_url":"https://pubmed.ncbi.nlm.nih.gov/35106798/","study_design":"longitudinal study","title":"GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cortical-pib-binding-in-lewy-body-disease-is-associated-with-19162186","doi":"10.1016/j.nbd.2008.12.008","journal":"Neurobiology of disease","n_participants":null,"pmid":"19162186","source_url":"https://pubmed.ncbi.nlm.nih.gov/19162186/","study_design":null,"title":"Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics","title_match":true,"year":2009},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-and-synuclein-rt-quic-as-differential-34635674","doi":"10.1038/s41531-021-00232-4","journal":"NPJ Parkinson's disease","n_participants":153,"pmid":"34635674","source_url":"https://pubmed.ncbi.nlm.nih.gov/34635674/","study_design":null,"title":"Neurofilament light chain and \u03b1-synuclein RT-QuIC as differential diagnostic biomarkers in parkinsonisms and related syndromes","title_match":true,"year":2021},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/mmse-and-moca-in-parkinson-s-disease-and-dementia-with-lewy-bodies-a-26852137","doi":"10.1007/s00702-016-1517-6","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":197,"pmid":"26852137","source_url":"https://pubmed.ncbi.nlm.nih.gov/26852137/","study_design":"cohort study","title":"MMSE and MoCA in Parkinson's disease and dementia with Lewy bodies: a multicenter 1-year follow-up study","title_match":true,"year":2016},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/ambroxol-as-a-novel-disease-modifying-treatment-for-parkinson-s-30738426","doi":"10.1186/s12883-019-1252-3","journal":"BMC neurology","n_participants":75,"pmid":"30738426","source_url":"https://pubmed.ncbi.nlm.nih.gov/30738426/","study_design":null,"title":"Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial","title_match":false,"year":2019},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-123i-meta-iodobenzylguanidine-myocardial-25793585","doi":"10.1371/journal.pone.0120540","journal":"PloS one","n_participants":61,"pmid":"25793585","source_url":"https://pubmed.ncbi.nlm.nih.gov/25793585/","study_design":null,"title":"Diagnostic accuracy of 123I-meta-iodobenzylguanidine myocardial scintigraphy in dementia with Lewy bodies: a multicenter study","title_match":true,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/semantic-memory-is-impaired-in-both-dementia-with-lewy-bodies-and-11160461","doi":"10.1136/jnnp.70.2.149","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"11160461","source_url":"https://pubmed.ncbi.nlm.nih.gov/11160461/","study_design":null,"title":"Semantic memory is impaired in both dementia with Lewy bodies and dementia of Alzheimer's type: a comparative neuropsychological study and literature review","title_match":true,"year":2001},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/low-sensitivity-in-clinical-diagnoses-of-dementia-with-lewy-bodies-19795154","doi":"10.1007/s00415-009-5324-y","journal":"Journal of neurology","n_participants":2861,"pmid":"19795154","source_url":"https://pubmed.ncbi.nlm.nih.gov/19795154/","study_design":null,"title":"Low sensitivity in clinical diagnoses of dementia with Lewy bodies","title_match":true,"year":2010},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/the-development-and-convergence-of-co-pathologies-in-alzheimer-s-33449993","doi":"10.1093/brain/awaa438","journal":"Brain : a journal of neurology","n_participants":522,"pmid":"33449993","source_url":"https://pubmed.ncbi.nlm.nih.gov/33449993/","study_design":null,"title":"The development and convergence of co-pathologies in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/a-nonsynonymous-mutation-in-plcg2-reduces-the-risk-of-alzheimer-s-31131421","doi":"10.1007/s00401-019-02026-8","journal":"Acta neuropathologica","n_participants":53627,"pmid":"31131421","source_url":"https://pubmed.ncbi.nlm.nih.gov/31131421/","study_design":null,"title":"A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity","title_match":true,"year":2019},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/csf-synuclein-improves-diagnostic-and-prognostic-performance-of-csf-23812319","doi":"10.1007/s00401-013-1148-z","journal":"Acta neuropathologica","n_participants":389,"pmid":"23812319","source_url":"https://pubmed.ncbi.nlm.nih.gov/23812319/","study_design":"longitudinal study","title":"CSF \u03b1-synuclein improves diagnostic and prognostic performance of CSF tau and A\u03b2 in Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/a-cross-sectional-study-of-synuclein-seed-amplification-assay-in-38770829","doi":"10.1002/alz.13858","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38770829","source_url":"https://pubmed.ncbi.nlm.nih.gov/38770829/","study_design":null,"title":"A cross-sectional study of \u03b1-synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function","title_match":true,"year":2024},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-locus-duplication-as-a-cause-of-familial-parkinson-s-15451224","doi":"10.1016/s0140-6736(04)17103-1","journal":"Lancet (London, England)","n_participants":null,"pmid":"15451224","source_url":"https://pubmed.ncbi.nlm.nih.gov/15451224/","study_design":null,"title":"Alpha-synuclein locus duplication as a cause of familial Parkinson's disease","title_match":true,"year":2004},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/what-genetics-tells-us-about-the-causes-and-mechanisms-of-parkinson-s-22013209","doi":"10.1152/physrev.00022.2010","journal":"Physiological reviews","n_participants":null,"pmid":"22013209","source_url":"https://pubmed.ncbi.nlm.nih.gov/22013209/","study_design":null,"title":"What genetics tells us about the causes and mechanisms of Parkinson's disease","title_match":false,"year":2011},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/phosphorylated-tdp-43-in-alzheimer-s-disease-and-dementia-with-lewy-19139911","doi":"10.1007/s00401-008-0480-1","journal":"Acta neuropathologica","n_participants":null,"pmid":"19139911","source_url":"https://pubmed.ncbi.nlm.nih.gov/19139911/","study_design":null,"title":"Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies","title_match":true,"year":2009},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/non-alzheimer-neurodegenerative-pathologies-and-their-combinations-23900711","doi":"10.1007/s00401-013-1157-y","journal":"Acta neuropathologica","n_participants":233,"pmid":"23900711","source_url":"https://pubmed.ncbi.nlm.nih.gov/23900711/","study_design":null,"title":"Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series","title_match":false,"year":2013},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/much-of-late-life-cognitive-decline-is-not-due-to-common-23798485","doi":"10.1002/ana.23964","journal":"Annals of neurology","n_participants":856,"pmid":"23798485","source_url":"https://pubmed.ncbi.nlm.nih.gov/23798485/","study_design":"longitudinal study","title":"Much of late life cognitive decline is not due to common neurodegenerative pathologies","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/molecular-imaging-with-pittsburgh-compound-b-confirmed-at-autopsy-a-17353389","doi":"10.1001/archneur.64.3.431","journal":"Archives of neurology","n_participants":null,"pmid":"17353389","source_url":"https://pubmed.ncbi.nlm.nih.gov/17353389/","study_design":null,"title":"Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report","title_match":false,"year":2007},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/dopamine-transporter-loss-visualized-with-fp-cit-spect-in-the-15210531","doi":"10.1001/archneur.61.6.919","journal":"Archives of neurology","n_participants":null,"pmid":"15210531","source_url":"https://pubmed.ncbi.nlm.nih.gov/15210531/","study_design":"cohort study","title":"Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies","title_match":true,"year":2004},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/colocalization-of-transactivation-responsive-dna-binding-protein-43-19018245","doi":"10.1097/nen.0b013e31818e8951","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"19018245","source_url":"https://pubmed.ncbi.nlm.nih.gov/19018245/","study_design":null,"title":"Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/tdp-43-pathology-in-alzheimer-s-disease-dementia-with-lewy-bodies-and-27495267","doi":"10.1111/bpa.12424","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"27495267","source_url":"https://pubmed.ncbi.nlm.nih.gov/27495267/","study_design":null,"title":"TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing","title_match":true,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/pathological-alpha-synuclein-propagates-through-neural-networks-25095794","doi":"10.1186/s40478-014-0088-8","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"25095794","source_url":"https://pubmed.ncbi.nlm.nih.gov/25095794/","study_design":null,"title":"Pathological alpha-synuclein propagates through neural networks","title_match":true,"year":2014},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/molecular-pathological-classification-of-neurodegenerative-diseases-26848654","doi":"10.3390/ijms17020189","journal":"International journal of molecular sciences","n_participants":null,"pmid":"26848654","source_url":"https://pubmed.ncbi.nlm.nih.gov/26848654/","study_design":null,"title":"Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision Medicine","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/impact-of-coexistent-alzheimer-pathology-on-the-natural-history-of-11956955","doi":"10.1007/s007020200027","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"11956955","source_url":"https://pubmed.ncbi.nlm.nih.gov/11956955/","study_design":null,"title":"Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease","title_match":false,"year":2002},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/neuropathology-of-dementia-in-patients-with-parkinson-s-disease-a-31444276","doi":"10.1136/jnnp-2019-321111","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"31444276","source_url":"https://pubmed.ncbi.nlm.nih.gov/31444276/","study_design":"systematic review","title":"Neuropathology of dementia in patients with Parkinson's disease: a systematic review of autopsy studies","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/olfactory-epithelium-amyloid-beta-and-paired-helical-filament-tau-20437581","doi":"10.1002/ana.21910","journal":"Annals of neurology","n_participants":null,"pmid":"20437581","source_url":"https://pubmed.ncbi.nlm.nih.gov/20437581/","study_design":null,"title":"Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/synuclein-toxicity-in-neurodegeneration-mechanism-and-therapeutic-28170377","doi":"10.1038/nm.4269","journal":"Nature medicine","n_participants":null,"pmid":"28170377","source_url":"https://pubmed.ncbi.nlm.nih.gov/28170377/","study_design":null,"title":"\u03b1-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies","title_match":true,"year":2017},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/functional-roles-of-reactive-astrocytes-in-neuroinflammation-and-37308616","doi":"10.1038/s41582-023-00822-1","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"37308616","source_url":"https://pubmed.ncbi.nlm.nih.gov/37308616/","study_design":null,"title":"Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/clearance-and-deposition-of-extracellular-alpha-synuclein-aggregates-18492487","doi":"10.1016/j.bbrc.2008.05.045","journal":"Biochemical and biophysical research communications","n_participants":null,"pmid":"18492487","source_url":"https://pubmed.ncbi.nlm.nih.gov/18492487/","study_design":null,"title":"Clearance and deposition of extracellular alpha-synuclein aggregates in microglia","title_match":true,"year":2008},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/antibody-aided-clearance-of-extracellular-synuclein-prevents-cell-to-23015436","doi":"10.1523/jneurosci.1292-12.2012","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"23015436","source_url":"https://pubmed.ncbi.nlm.nih.gov/23015436/","study_design":null,"title":"Antibody-aided clearance of extracellular \u03b1-synuclein prevents cell-to-cell aggregate transmission","title_match":true,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/astrocytic-expression-of-parkinson-s-disease-related-a53t-alpha-20409326","doi":"10.1186/1756-6606-3-12","journal":"Molecular brain","n_participants":null,"pmid":"20409326","source_url":"https://pubmed.ncbi.nlm.nih.gov/20409326/","study_design":null,"title":"Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice","title_match":true,"year":2010},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/impact-of-neurodegenerative-diseases-on-human-adult-hippocampal-34672693","doi":"10.1126/science.abl5163","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"34672693","source_url":"https://pubmed.ncbi.nlm.nih.gov/34672693/","study_design":null,"title":"Impact of neurodegenerative diseases on human adult hippocampal neurogenesis","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/microglial-phenotypes-and-toll-like-receptor-2-in-the-substantia-25099483","doi":"10.1186/s40478-014-0090-1","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"25099483","source_url":"https://pubmed.ncbi.nlm.nih.gov/25099483/","study_design":null,"title":"Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients","title_match":true,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/next-generation-active-immunization-approach-for-synucleinopathies-24525765","doi":"10.1007/s00401-014-1256-4","journal":"Acta neuropathologica","n_participants":null,"pmid":"24525765","source_url":"https://pubmed.ncbi.nlm.nih.gov/24525765/","study_design":null,"title":"Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials","title_match":false,"year":2014},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/in-vivo-microglia-activation-in-very-early-dementia-with-lewy-bodies-22841687","doi":"10.1016/j.parkreldis.2012.07.002","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"22841687","source_url":"https://pubmed.ncbi.nlm.nih.gov/22841687/","study_design":null,"title":"In\u00a0vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease","title_match":true,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/assessment-of-neuroinflammation-in-patients-with-idiopathic-rapid-eye-28684245","doi":"10.1016/s1474-4422(17)30173-4","journal":"The Lancet. Neurology","n_participants":20,"pmid":"28684245","source_url":"https://pubmed.ncbi.nlm.nih.gov/28684245/","study_design":"case-control study","title":"Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study","title_match":false,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-neurogranin-and-ykl-40-as-biomarkers-of-alzheimer-26783546","doi":"10.1002/acn3.266","journal":"Annals of clinical and translational neurology","n_participants":338,"pmid":"26783546","source_url":"https://pubmed.ncbi.nlm.nih.gov/26783546/","study_design":null,"title":"Cerebrospinal fluid neurogranin and YKL-40 as biomarkers of Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/a-perspective-on-nrf2-signaling-pathway-for-neuroinflammation-a-35126058","doi":"10.3389/fncel.2021.787258","journal":"Frontiers in cellular neuroscience","n_participants":null,"pmid":"35126058","source_url":"https://pubmed.ncbi.nlm.nih.gov/35126058/","study_design":null,"title":"A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cell-death-mechanisms-in-parkinson-s-disease-10809400","doi":"10.1007/s007020050001","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"10809400","source_url":"https://pubmed.ncbi.nlm.nih.gov/10809400/","study_design":null,"title":"Cell death mechanisms in Parkinson's disease","title_match":false,"year":2000},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/burden-of-illness-among-patients-with-psychosis-due-to-dementia-with-36893766","doi":"10.1177/15333175231163521","journal":"American Journal of Alzheimer s Disease & Other Dementias\u00ae","n_participants":null,"pmid":"36893766","source_url":"https://pubmed.ncbi.nlm.nih.gov/36893766/","study_design":null,"title":"Burden of Illness Among Patients with Psychosis due to Dementia with Lewy Bodies and Other Dementias","title_match":true,"year":2023},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/healthcare-costs-among-patients-with-dementiarelated-psychosis-1a65cff1","doi":"10.1002/alz.047091","journal":"Alzheimer s & Dementia","n_participants":442,"pmid":null,"source_url":"https://doi.org/10.1002/alz.047091","study_design":null,"title":"Healthcare costs among patients with dementia\u2010related psychosis: Comparing dementia with Lewy bodies with other dementias","title_match":true,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/a-patient-journey-analysis-identification-and-treatment-of-dementia-6d3f04fc","doi":"10.1002/alz.047079","journal":"Alzheimer s & Dementia","n_participants":974,"pmid":null,"source_url":"https://doi.org/10.1002/alz.047079","study_design":"systematic review","title":"A patient journey analysis: Identification and treatment of dementia with Lewy bodies","title_match":true,"year":2020},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/p2526-geographical-variations-in-diagnostic-rates-for-dementia-with-f15b63ca","doi":"10.1016/j.jalz.2017.06.1184","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.jalz.2017.06.1184","study_design":null,"title":"[P2\u2013526]: GEOGRAPHICAL VARIATIONS IN DIAGNOSTIC RATES FOR DEMENTIA WITH LEWY BODIES IN CLINICAL SERVICES","title_match":true,"year":2017},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/association-of-neighbourhood-walkability-with-pathophysiological-41434663","doi":"10.1002/alz70860_105259","journal":"Alzheimer s & Dementia","n_participants":255,"pmid":"41434663","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12726461/","study_design":"cross-sectional","title":"Association of neighbourhood walkability with pathophysiological markers and depressive symptoms by area deprivation index and cognitive status in older adults","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/geospatial-analysis-of-the-association-of-cardiometabolic-diseases-b956e865","doi":"10.1038/s41531-026-01557-8","journal":"npj Parkinson s Disease","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1038/s41531-026-01557-8","study_design":"case-control study","title":"Geospatial analysis of the association of cardiometabolic diseases and incident Lewy body dementia in the Medicare population","title_match":true,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/trends-in-diagnosis-of-dementia-subtypes-in-nationwide-medicare-500e86e2","doi":"10.1002/alz.093412","journal":"Alzheimer s & Dementia","n_participants":100,"pmid":null,"source_url":"https://doi.org/10.1002/alz.093412","study_design":null,"title":"Trends in Diagnosis of Dementia Subtypes in Nationwide Medicare Claims, 2015\u20102021, by Race/Ethnicity, Sex, and Neighborhood Socioeconomic Status","title_match":false,"year":2024},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/resting-state-electroencephalography-alpha-activity-predicts-41357359","doi":"10.1093/sleepadvances/zpaf081","journal":"SLEEP Advances","n_participants":null,"pmid":"41357359","source_url":"https://pubmed.ncbi.nlm.nih.gov/41357359/","study_design":null,"title":"Resting state electroencephalography alpha activity predicts cognitive scores in rapid eye movement sleep behavior disorder","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/geographic-proximity-neuropathology-and-adrc-brain-donation-bcef8f4e","doi":"10.1002/alz.057512","journal":"Alzheimer s & Dementia","n_participants":428,"pmid":null,"source_url":"https://doi.org/10.1002/alz.057512","study_design":null,"title":"Geographic proximity, neuropathology and ADRC brain donation","title_match":false,"year":2021},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/postmortem-associations-between-alzheimer-disease-pathology-and-41610380","doi":"10.1212/wnl.0000000000214351","journal":"Neurology","n_participants":85,"pmid":"41610380","source_url":"https://pubmed.ncbi.nlm.nih.gov/41610380/","study_design":"cohort study","title":"Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/evaluation-of-copathology-and-clinical-trajectories-in-individuals-41396614","doi":"10.1001/jamaneurol.2025.4974","journal":"JAMA Neurology","n_participants":365,"pmid":"41396614","source_url":"https://pubmed.ncbi.nlm.nih.gov/41396614/","study_design":"cohort study","title":"Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clinical Mismatch","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-4-linked-effects-on-clinical-features-and-neuropathology-in-41074912","doi":"10.1002/alz.70795","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41074912","source_url":"https://pubmed.ncbi.nlm.nih.gov/41074912/","study_design":null,"title":"APOE \u03b54 linked effects on clinical features and neuropathology in dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-of-alzheimer-disease-parkinson-disease-and-371f2186","doi":"10.20900/agmr20250013","journal":"Advances in Geriatric Medicine and Research","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20900/agmr20250013","study_design":null,"title":"Neuropsychiatric Symptoms of Alzheimer Disease, Parkinson Disease and Lewy Body Dementia: Genetic, Clinical and Therapeutic Overlaps","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/early-behavioral-and-cognitive-changes-in-patients-with-41809433","doi":"10.1212/wn9.0000000000000055","journal":"Neurology Open Access","n_participants":1028,"pmid":"41809433","source_url":"https://pubmed.ncbi.nlm.nih.gov/41809433/","study_design":"cohort study","title":"Early Behavioral and Cognitive Changes in Patients With Pathologically Confirmed Alzheimer Disease, Lewy Body Dementia, and Mixed Dementia","title_match":true,"year":2026},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/ibuprofen-modulates-inflammatory-and-autophagy-associated-pathways-e38b6498","doi":"10.1186/s12974-026-04038-0","journal":"Journal of Neuroinflammation","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1186/s12974-026-04038-0","study_design":null,"title":"Ibuprofen modulates inflammatory and autophagy-associated pathways linked to neurodegenerative pathology in APOE-context-dependent cellular models","title_match":false,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/regional-distribution-of-mineralized-blood-vessels-in-alzheimer-f73fe408","doi":"10.1016/j.neurobiolaging.2026.09.001","journal":"Neurobiology of Aging","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.neurobiolaging.2026.09.001","study_design":null,"title":"Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study","title_match":false,"year":2026},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/a-causal-association-between-drug-use-and-cognitive-impairment-a-41220200","doi":"10.1002/brb3.71057","journal":"Brain and Behavior","n_participants":null,"pmid":"41220200","source_url":"https://pubmed.ncbi.nlm.nih.gov/41220200/","study_design":null,"title":"A Causal Association Between Drug Use and Cognitive Impairment: A Two\u2010Sample Mendelian Randomization Study","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/elucidating-shared-genetic-signals-between-type-2-diabetes-and-three-42681870","doi":"10.1016/j.xhgg.2026.100667","journal":"Human Genetics and Genomics Advances","n_participants":null,"pmid":"42681870","source_url":"https://pubmed.ncbi.nlm.nih.gov/42681870/","study_design":null,"title":"Elucidating shared genetic signals between type 2 diabetes and three neurodegenerative dementia phenotypes","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alzheimer-combination-therapies-overview-and-scenarios-41145337","doi":"10.1016/j.tjpad.2025.100328","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":null,"pmid":"41145337","source_url":"https://pubmed.ncbi.nlm.nih.gov/41145337/","study_design":"clinical trial","title":"Alzheimer Combination Therapies: Overview and Scenarios","title_match":false,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/nose-to-brain-delivery-of-curcumin-loaded-therapeutic-nanostructures-41482856","doi":"10.1002/bdd.70021","journal":"Biopharmaceutics & Drug Disposition","n_participants":null,"pmid":"41482856","source_url":"https://pubmed.ncbi.nlm.nih.gov/41482856/","study_design":null,"title":"Nose to Brain Delivery of Curcumin Loaded Therapeutic Nanostructures for Neurodegenerative Diseases","title_match":false,"year":2026},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/application-of-mini-mental-state-examination-and-montreal-cognitive-40116743","doi":"10.1080/23279095.2025.2478204","journal":"Applied Neuropsychology Adult","n_participants":66,"pmid":"40116743","source_url":"https://pubmed.ncbi.nlm.nih.gov/40116743/","study_design":null,"title":"Application of mini-mental state examination and Montreal Cognitive Assessment in the diagnosis of dementia with Lewy bodies and Alzheimer\u2019s disease","title_match":true,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/refining-the-diagnostic-accuracy-of-parkinsonian-disorders-using-41213966","doi":"10.1038/s41531-025-01157-y","journal":"npj Parkinson s Disease","n_participants":null,"pmid":"41213966","source_url":"https://pubmed.ncbi.nlm.nih.gov/41213966/","study_design":null,"title":"Refining the diagnostic accuracy of Parkinsonian disorders using metaphenomic annotation of the clinicopathological literature","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-seeding-amplification-assays-in-lewy-body-dementia-a-40598304","doi":"10.1186/s13024-025-00868-3","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"40598304","source_url":"https://pubmed.ncbi.nlm.nih.gov/40598304/","study_design":null,"title":"Alpha-synuclein seeding amplification assays in Lewy body dementia: a brief review","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/unravelling-the-plasma-proteome-pioneering-biomarkers-for-40613333","doi":"10.1002/alz.70162","journal":"Alzheimer s & Dementia","n_participants":248,"pmid":"40613333","source_url":"https://pubmed.ncbi.nlm.nih.gov/40613333/","study_design":null,"title":"Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/comorbid-pathologies-and-their-impact-on-dementia-with-lewy-40868991","doi":"10.3390/ijms26167674","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"40868991","source_url":"https://pubmed.ncbi.nlm.nih.gov/40868991/","study_design":null,"title":"Comorbid Pathologies and Their Impact on Dementia with Lewy Bodies\u2014Current View","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/longitudinal-remote-sleep-and-cognitive-research-in-older-adults-with-40435500","doi":"10.2196/72824","journal":"JMIR Aging","n_participants":41,"pmid":"40435500","source_url":"https://pubmed.ncbi.nlm.nih.gov/40435500/","study_design":"longitudinal study","title":"Longitudinal Remote Sleep and Cognitive Research in Older Adults With Mild Cognitive Impairment and Dementia: Prospective Feasibility Cohort Study","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/dementia-in-severe-schizophrenia-41920573","doi":"10.1001/jamapsychiatry.2026.0171","journal":"JAMA Psychiatry","n_participants":155,"pmid":"41920573","source_url":"https://pubmed.ncbi.nlm.nih.gov/41920573/","study_design":"cohort study","title":"Dementia in Severe Schizophrenia","title_match":false,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/implications-and-opportunities-regarding-biological-frameworks-in-40684248","doi":"10.1002/alz.70470","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40684248","source_url":"https://pubmed.ncbi.nlm.nih.gov/40684248/","study_design":null,"title":"Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cutaneous-phosphorylated-alphasynuclein-in-lewy-body-dementia-41449577","doi":"10.1002/acn3.70291","journal":"Annals of Clinical and Translational Neurology","n_participants":151,"pmid":"41449577","source_url":"https://pubmed.ncbi.nlm.nih.gov/41449577/","study_design":"cross-sectional","title":"Cutaneous Phosphorylated Alpha\u2010Synuclein in Lewy Body Dementia","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/comparing-phenotypic-features-between-parkinsons-disease-dementia-and-41665721","doi":"10.1007/s00415-026-13649-9","journal":"Journal of Neurology","n_participants":31,"pmid":"41665721","source_url":"https://pubmed.ncbi.nlm.nih.gov/41665721/","study_design":null,"title":"Comparing phenotypic features between Parkinson\u2019s disease dementia and dementia with Lewy bodies","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cerebral-small-vessel-disease-in-memory-center-patients-with-dementia-40646592","doi":"10.1186/s13195-025-01805-8","journal":"Alzheimer s Research & Therapy","n_participants":71,"pmid":"40646592","source_url":"https://pubmed.ncbi.nlm.nih.gov/40646592/","study_design":null,"title":"Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer\u2019s disease","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/inflammatory-changes-in-early-dementia-with-lewy-bodies-40933044","doi":"10.3389/fneur.2025.1640614","journal":"Frontiers in Neurology","n_participants":64,"pmid":"40933044","source_url":"https://pubmed.ncbi.nlm.nih.gov/40933044/","study_design":"cohort study","title":"Inflammatory changes in early dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/synuclein-seed-amplification-assay-in-lewy-body-dementia-versus-41211301","doi":"10.1002/dad2.70203","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":null,"pmid":"41211301","source_url":"https://pubmed.ncbi.nlm.nih.gov/41211301/","study_design":null,"title":"\u03b1\u2010Synuclein seed amplification assay in Lewy body dementia versus Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/salivary-biomarkers-for-the-molecular-diagnosis-of-dementia-with-lewy-40084669","doi":"10.1177/13872877251317720","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40084669","source_url":"https://pubmed.ncbi.nlm.nih.gov/40084669/","study_design":null,"title":"Salivary biomarkers for the molecular diagnosis of dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/lumen-prototype-conversational-ai-to-streamline-dementia-assessments-a9f822e1","doi":"10.1192/bjo.2025.10185","journal":"BJPsych Open","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1192/bjo.2025.10185","study_design":null,"title":"LUMEN: Prototype Conversational AI to Streamline Dementia Assessments","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/impact-of-neuropsychiatric-symptoms-on-caregiver-burden-of-people-40390335","doi":"10.1111/psyg.70051","journal":"Psychogeriatrics","n_participants":30,"pmid":"40390335","source_url":"https://pubmed.ncbi.nlm.nih.gov/40390335/","study_design":null,"title":"Impact of Neuropsychiatric Symptoms on Caregiver Burden of People With Dementia With Lewy Bodies: A Multicentre Prospective Longitudinal Study","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/self-versus-caregiver-reported-apathy-across-neurological-disorders-40568416","doi":"10.1093/braincomms/fcaf235","journal":"Brain Communications","n_participants":335,"pmid":"40568416","source_url":"https://pubmed.ncbi.nlm.nih.gov/40568416/","study_design":null,"title":"Self- versus caregiver-reported apathy across neurological disorders","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/clinical-practice-guidelines-for-dementia-recommendations-for-the-39944528","doi":"10.12779/dnd.2025.24.1.24","journal":"Dementia and Neurocognitive Disorders","n_participants":null,"pmid":"39944528","source_url":"https://pubmed.ncbi.nlm.nih.gov/39944528/","study_design":null,"title":"Clinical Practice Guidelines for Dementia: Recommendations for the Pharmacological Treatment of Behavioral and Psychological Symptoms","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/cholinesterase-inhibitors-for-patients-with-dementia-patterns-of-41527747","doi":"10.1177/13872877251411418","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"41527747","source_url":"https://pubmed.ncbi.nlm.nih.gov/41527747/","study_design":null,"title":"Cholinesterase inhibitors for patients with dementia: Patterns of prescribing and disparities in treatment","title_match":false,"year":2026},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/clinical-implication-of-anemia-in-older-patients-with-dementia-with-39964627","doi":"10.1007/s40520-025-02958-0","journal":"Aging Clinical and Experimental Research","n_participants":null,"pmid":"39964627","source_url":"https://pubmed.ncbi.nlm.nih.gov/39964627/","study_design":"cross-sectional","title":"Clinical implication of anemia in older patients with dementia with lewy bodies","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-biomarkers-for-diagnosis-and-prediction-of-40133253","doi":"10.1038/s41467-025-56756-3","journal":"Nature Communications","n_participants":49,"pmid":"40133253","source_url":"https://pubmed.ncbi.nlm.nih.gov/40133253/","study_design":"cohort study","title":"Performance of plasma biomarkers for diagnosis and prediction of dementia in a Brazilian cohort","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/targeted-proteomic-biomarker-profiling-using-nulisa-in-a-cohort-40318118","doi":"10.1002/alz.70166","journal":"Alzheimer s & Dementia","n_participants":252,"pmid":"40318118","source_url":"https://pubmed.ncbi.nlm.nih.gov/40318118/","study_design":"cross-sectional","title":"Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/incidence-and-prevalence-of-dementia-with-lewy-bodies-42113545","doi":"10.1001/jamaneurol.2026.1206","journal":"JAMA Neurology","n_participants":null,"pmid":"42113545","source_url":"https://pubmed.ncbi.nlm.nih.gov/42113545/","study_design":"systematic review","title":"Incidence and Prevalence of Dementia With Lewy Bodies","title_match":true,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/lewy-body-dementia-promotion-by-air-pollutants-40906862","doi":"10.1126/science.adu4132","journal":"Science","n_participants":null,"pmid":"40906862","source_url":"https://pubmed.ncbi.nlm.nih.gov/40906862/","study_design":null,"title":"Lewy body dementia promotion by air pollutants","title_match":true,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/evaluating-the-diagnostic-performance-of-six-plasma-biomarkers-for-40181481","doi":"10.1186/s13195-025-01712-y","journal":"Alzheimer s Research & Therapy","n_participants":668,"pmid":"40181481","source_url":"https://pubmed.ncbi.nlm.nih.gov/40181481/","study_design":"cross-sectional","title":"Evaluating the diagnostic performance of six plasma biomarkers for Alzheimer\u2019s disease and other neurodegenerative dementias in a large Chinese cohort","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/plasma-ptau181-and-amyloid-markers-predict-conversion-to-dementia-in-39761530","doi":"10.1093/brain/awaf003","journal":"Brain","n_participants":158,"pmid":"39761530","source_url":"https://pubmed.ncbi.nlm.nih.gov/39761530/","study_design":"cohort study","title":"Plasma pTau181 and amyloid markers predict conversion to dementia in idiopathic REM sleep behaviour disorder","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/iron-species-in-cerebrospinal-fluid-and-dementia-risk-in-subjects-40609908","doi":"10.1016/j.neuro.2025.06.006","journal":"NeuroToxicology","n_participants":56,"pmid":"40609908","source_url":"https://pubmed.ncbi.nlm.nih.gov/40609908/","study_design":null,"title":"Iron species in cerebrospinal fluid and dementia risk in subjects with mild cognitive impairment: A cohort study","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/clinical-evolution-of-neuropsychiatric-symptoms-in-alzheimer-s-40296198","doi":"10.1002/gps.70084","journal":"International Journal of Geriatric Psychiatry","n_participants":37,"pmid":"40296198","source_url":"https://pubmed.ncbi.nlm.nih.gov/40296198/","study_design":"cohort study","title":"Clinical Evolution of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies in a Post\u2010Mortem Cohort","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/prevalence-and-clinical-effects-of-lewy-body-pathology-in-non-prion-41792827","doi":"10.1186/s13195-026-02004-9","journal":"Alzheimer s Research & Therapy","n_participants":171,"pmid":"41792827","source_url":"https://pubmed.ncbi.nlm.nih.gov/41792827/","study_design":null,"title":"Prevalence and clinical effects of Lewy Body pathology in non-prion rapidly progressive dementias: a retrospective cohort study","title_match":true,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/associations-of-semaglutide-with-alzheimer-s-disease-related-40552638","doi":"10.1177/13872877251351329","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40552638","source_url":"https://pubmed.ncbi.nlm.nih.gov/40552638/","study_design":null,"title":"Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/artificial-intelligence-and-omics-based-autoantibody-profiling-in-40406128","doi":"10.3389/fimmu.2025.1537659","journal":"Frontiers in Immunology","n_participants":35,"pmid":"40406128","source_url":"https://pubmed.ncbi.nlm.nih.gov/40406128/","study_design":"longitudinal study","title":"Artificial intelligence and omics-based autoantibody profiling in dementia","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/development-and-validation-of-machine-learning-models-with-blood-40115175","doi":"10.1016/j.eclinm.2025.103142","journal":"EClinicalMedicine","n_participants":1324,"pmid":"40115175","source_url":"https://pubmed.ncbi.nlm.nih.gov/40115175/","study_design":null,"title":"Development and validation of machine learning models with blood-based digital biomarkers for Alzheimer\u2019s disease diagnosis: a multicohort diagnostic study","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuropathology-of-lewy-body-dementia-lewy-related-pathology-synuclein-41185066","doi":"10.1186/s13024-025-00900-6","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"41185066","source_url":"https://pubmed.ncbi.nlm.nih.gov/41185066/","study_design":null,"title":"Neuropathology of Lewy body dementia: Lewy-related pathology, \u03b1-synuclein oligomers, and comorbid pathologies","title_match":true,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/molecular-insights-into-synuclein-fibrillation-a-raman-spectroscopy-39875340","doi":"10.1021/acschemneuro.4c00726","journal":"ACS Chemical Neuroscience","n_participants":null,"pmid":"39875340","source_url":"https://pubmed.ncbi.nlm.nih.gov/39875340/","study_design":null,"title":"Molecular Insights into \u03b1-Synuclein Fibrillation: A Raman Spectroscopy and Machine Learning Approach","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-actigraphy-in-alzheimers-disease-using-a-40399918","doi":"10.1186/s13195-025-01751-5","journal":"Alzheimer s Research & Therapy","n_participants":29,"pmid":"40399918","source_url":"https://pubmed.ncbi.nlm.nih.gov/40399918/","study_design":"cross-sectional","title":"Diagnostic performance of actigraphy in Alzheimer\u2019s disease using a machine learning classifier \u2013 a cross-sectional memory clinic study","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/molecular-features-of-human-pathological-tau-distinguish-tauopathy-41616780","doi":"10.1016/j.cell.2025.12.036","journal":"Cell","n_participants":null,"pmid":"41616780","source_url":"https://pubmed.ncbi.nlm.nih.gov/41616780/","study_design":null,"title":"Molecular features of human pathological tau distinguish tauopathy-associated dementias","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/enhanced-diagnostic-interpretation-of-the-moca-using-machine-learning-41799879","doi":"10.3389/fnins.2026.1679649","journal":"Frontiers in Neuroscience","n_participants":38746,"pmid":"41799879","source_url":"https://pubmed.ncbi.nlm.nih.gov/41799879/","study_design":null,"title":"Enhanced diagnostic interpretation of the MoCA using machine learning","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-aggregation-induces-prominent-cellular-lipid-changes-40226383","doi":"10.1093/braincomms/fcaf133","journal":"Brain Communications","n_participants":null,"pmid":"40226383","source_url":"https://pubmed.ncbi.nlm.nih.gov/40226383/","study_design":null,"title":"Alpha-synuclein aggregation induces prominent cellular lipid changes as revealed by Raman spectroscopy and machine learning analysis","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/irma-machine-learning-based-harmonization-of-18-f-fdg-pet-brain-scans-39964544","doi":"10.1007/s00259-025-07114-4","journal":"European Journal of Nuclear Medicine and Molecular Imaging","n_participants":null,"pmid":"39964544","source_url":"https://pubmed.ncbi.nlm.nih.gov/39964544/","study_design":null,"title":"IRMA: Machine learning-based harmonization of $$^{18}$$F-FDG PET brain scans in multi-center studies","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/metabolomic-signatures-and-machine-learning-models-for-distinguishing-41433352","doi":"10.1002/alz70863_110610","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41433352","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12724972/","study_design":null,"title":"Metabolomic Signatures and Machine Learning Models for Distinguishing Alzheimer's Disease and Dementia with Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/development-of-a-simplified-smell-test-to-identify-parkinsons-disease-40268961","doi":"10.1038/s41531-025-00904-5","journal":"npj Parkinson s Disease","n_participants":301,"pmid":"40268961","source_url":"https://pubmed.ncbi.nlm.nih.gov/40268961/","study_design":"case-control study","title":"Development of a simplified smell test to identify Parkinson\u2019s disease using multiple cohorts, machine learning and item response theory","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-modified-synuclein-seed-amplification-assay-in-lewy-body-dementia-41238048","doi":"10.1016/j.jneumeth.2025.110617","journal":"Journal of Neuroscience Methods","n_participants":null,"pmid":"41238048","source_url":"https://pubmed.ncbi.nlm.nih.gov/41238048/","study_design":null,"title":"A modified \u03b1-synuclein seed amplification assay in Lewy body dementia using Raman spectroscopy and machine learning analysis","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/discriminative-plasma-lipidomic-signatures-of-dementia-with-lewy-41834991","doi":"10.2147/ndt.s561999","journal":"Neuropsychiatric Disease and Treatment","n_participants":null,"pmid":"41834991","source_url":"https://pubmed.ncbi.nlm.nih.gov/41834991/","study_design":"cross-sectional","title":"Discriminative Plasma Lipidomic Signatures of Dementia with Lewy Bodies and Alzheimer\u2019s Disease: A Targeted Mass Spectrometry and Machine Learning Approach","title_match":true,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-and-neuroimagingbased-brain-age-in-mild-39821434","doi":"10.1111/pcn.13777","journal":"Psychiatry and Clinical Neurosciences","n_participants":185,"pmid":"39821434","source_url":"https://pubmed.ncbi.nlm.nih.gov/39821434/","study_design":"cross-sectional","title":"Neuropsychiatric symptoms and neuroimaging\u2010based brain age in mild cognitive impairment and early dementia: A multicenter study","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/actitect-a-generalizable-machine-learning-pipeline-for-rem-sleep-42286243","doi":"10.1038/s41746-026-02738-8","journal":"npj Digital Medicine","n_participants":31,"pmid":"42286243","source_url":"https://pubmed.ncbi.nlm.nih.gov/42286243/","study_design":null,"title":"ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/sleep-disorders-in-neurodegenerative-diseases-with-dementia-a-41096196","doi":"10.3390/jcm14197119","journal":"Journal of Clinical Medicine","n_participants":null,"pmid":"41096196","source_url":"https://pubmed.ncbi.nlm.nih.gov/41096196/","study_design":null,"title":"Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/recent-advances-in-neuroimaging-of-alzheimer-s-disease-and-related-40922096","doi":"10.1002/alz.70648","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40922096","source_url":"https://pubmed.ncbi.nlm.nih.gov/40922096/","study_design":null,"title":"Recent advances in neuroimaging of Alzheimer's disease and related dementias","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/from-mechanisms-to-future-therapy-a-synopsis-of-isolated-rem-sleep-39934903","doi":"10.1186/s13024-025-00809-0","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"39934903","source_url":"https://pubmed.ncbi.nlm.nih.gov/39934903/","study_design":null,"title":"From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/free-water-predicts-dementia-with-lewy-bodies-in-isolated-rem-sleep-40970479","doi":"10.1002/alz.70570","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40970479","source_url":"https://pubmed.ncbi.nlm.nih.gov/40970479/","study_design":null,"title":"Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder","title_match":true,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/alterations-in-non-rem-sleep-and-eeg-spectra-precede-rem-sleep-39973511","doi":"10.1177/1877718x241310723","journal":"Journal of Parkinson s Disease","n_participants":null,"pmid":"39973511","source_url":"https://pubmed.ncbi.nlm.nih.gov/39973511/","study_design":null,"title":"Alterations in non-REM sleep and EEG spectra precede REM-sleep deficits in a model of synucleinopathy","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/exploring-the-relationship-between-epilepsy-and-neurodegenerative-01964e62","doi":"10.37897/rjn.2025.3.2","journal":"Romanian Journal of Neurology","n_participants":50,"pmid":null,"source_url":"https://doi.org/10.37897/rjn.2025.3.2","study_design":"longitudinal study","title":"Exploring the relationship between epilepsy and neurodegenerative diseases","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/sympathetic-and-parasympathetic-subtypes-of-body-first-lewy-body-40082617","doi":"10.1038/s41593-025-01910-9","journal":"Nature Neuroscience","n_participants":173,"pmid":"40082617","source_url":"https://pubmed.ncbi.nlm.nih.gov/40082617/","study_design":null,"title":"Sympathetic and parasympathetic subtypes of body-first Lewy body disease observed in postmortem tissue from prediagnostic individuals","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/abundant-non-inclusion-synuclein-pathology-in-lewy-body-negative-40314782","doi":"10.1007/s00401-025-02871-w","journal":"Acta Neuropathologica","n_participants":null,"pmid":"40314782","source_url":"https://pubmed.ncbi.nlm.nih.gov/40314782/","study_design":null,"title":"Abundant non-inclusion \u03b1-synuclein pathology in Lewy body-negative LRRK2-mutant cases","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/lewy-body-diseases-and-the-gut-39885558","doi":"10.1186/s13024-025-00804-5","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"39885558","source_url":"https://pubmed.ncbi.nlm.nih.gov/39885558/","study_design":null,"title":"Lewy body diseases and the gut","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/research-models-to-study-lewy-body-dementia-40269912","doi":"10.1186/s13024-025-00837-w","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"40269912","source_url":"https://pubmed.ncbi.nlm.nih.gov/40269912/","study_design":null,"title":"Research models to study lewy body dementia","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/increased-plasma-dopa-decarboxylase-levels-in-lewy-body-disorders-are-39881147","doi":"10.1038/s41467-025-56293-z","journal":"Nature Communications","n_participants":71,"pmid":"39881147","source_url":"https://pubmed.ncbi.nlm.nih.gov/39881147/","study_design":"longitudinal study","title":"Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment","title_match":true,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/longitudinal-fdg-pet-metabolic-change-along-the-lewy-body-continuum-39804619","doi":"10.1001/jamaneurol.2024.4643","journal":"JAMA Neurology","n_participants":72,"pmid":"39804619","source_url":"https://pubmed.ncbi.nlm.nih.gov/39804619/","study_design":"case-control study","title":"Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum","title_match":true,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-effect-of-lewy-body-co-pathology-on-the-clinical-and-imaging-39888600","doi":"10.1093/brain/awaf037","journal":"Brain","n_participants":661,"pmid":"39888600","source_url":"https://pubmed.ncbi.nlm.nih.gov/39888600/","study_design":"longitudinal study","title":"The effect of Lewy body (co-)pathology on the clinical and imaging phenotype of amnestic patients","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cholinergic-degeneration-and-early-cognitive-signs-in-prodromal-lewy-39985502","doi":"10.1002/alz.14584","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"39985502","source_url":"https://pubmed.ncbi.nlm.nih.gov/39985502/","study_design":"cross-sectional","title":"Cholinergic degeneration and early cognitive signs in prodromal Lewy body dementia","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuroimaging-and-plasma-biomarker-differences-and-commonalities-in-40403153","doi":"10.1002/alz.70274","journal":"Alzheimer s & Dementia","n_participants":47,"pmid":"40403153","source_url":"https://pubmed.ncbi.nlm.nih.gov/40403153/","study_design":null,"title":"Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypes","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-hypothesis-explaining-alzheimer-s-disease-parkinson-s-disease-and-40528299","doi":"10.1002/alz.70363","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40528299","source_url":"https://pubmed.ncbi.nlm.nih.gov/40528299/","study_design":null,"title":"A hypothesis explaining Alzheimer's disease, Parkinson's disease, and dementia with Lewy bodies overlap","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/association-of-alzheimers-and-lewy-body-disease-pathology-with-basal-39865328","doi":"10.1186/s13195-025-01678-x","journal":"Alzheimer s Research & Therapy","n_participants":248,"pmid":"39865328","source_url":"https://pubmed.ncbi.nlm.nih.gov/39865328/","study_design":null,"title":"Association of Alzheimer\u2019s and Lewy body disease pathology with basal forebrain volume and cognitive impairment","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/differential-role-of-c-terminal-truncations-on-alpha-synuclein-40858624","doi":"10.1038/s41531-025-01084-y","journal":"npj Parkinson s Disease","n_participants":null,"pmid":"40858624","source_url":"https://pubmed.ncbi.nlm.nih.gov/40858624/","study_design":null,"title":"Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/changes-in-dti-alps-index-and-its-associations-with-neuronal-damage-40921114","doi":"10.1016/j.parkreldis.2025.108014","journal":"Parkinsonism & Related Disorders","n_participants":32,"pmid":"40921114","source_url":"https://pubmed.ncbi.nlm.nih.gov/40921114/","study_design":"longitudinal study","title":"Changes in DTI-ALPS index and its associations with neuronal damage in Lewy body disease","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cortical-microstructural-abnormalities-in-dementia-with-lewy-bodies-40355490","doi":"10.1038/s41531-025-00944-x","journal":"npj Parkinson s Disease","n_participants":57,"pmid":"40355490","source_url":"https://pubmed.ncbi.nlm.nih.gov/40355490/","study_design":null,"title":"Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer\u2019s disease copathologies","title_match":true,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/hippocampal-mitophagy-alterations-in-mapt-associated-frontotemporal-39994734","doi":"10.1186/s40478-025-01955-8","journal":"Acta Neuropathologica Communications","n_participants":null,"pmid":"39994734","source_url":"https://pubmed.ncbi.nlm.nih.gov/39994734/","study_design":null,"title":"Hippocampal mitophagy alterations in MAPT-associated frontotemporal dementia with parkinsonism","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/it-is-time-to-share-alzheimer-biomarker-results-in-dementia-with-lewy-40636063","doi":"10.1002/dad2.70144","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":null,"pmid":"40636063","source_url":"https://pubmed.ncbi.nlm.nih.gov/40636063/","study_design":null,"title":"It is time to share Alzheimer biomarker results in dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/eeg-network-reorganization-across-alzheimer-s-disease-frontotemporal-41700307","doi":"10.1002/dad2.70275","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":173,"pmid":"41700307","source_url":"https://pubmed.ncbi.nlm.nih.gov/41700307/","study_design":null,"title":"EEG network reorganization across Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/quantification-of-lewy-body-pathology-by-cerebrospinal-fluid-endpoint-40549179","doi":"10.1007/s00401-025-02904-4","journal":"Acta Neuropathologica","n_participants":null,"pmid":"40549179","source_url":"https://pubmed.ncbi.nlm.nih.gov/40549179/","study_design":null,"title":"Quantification of Lewy body pathology by cerebrospinal fluid endpoint dilution RT-QuIC in a neuropathological autopsy cohort of clinically heterogeneous participants","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/sex-differences-in-associations-of-lewy-body-disease-with-alzheimer-s-40646704","doi":"10.1002/ana.27308","journal":"Annals of Neurology","n_participants":1277,"pmid":"40646704","source_url":"https://pubmed.ncbi.nlm.nih.gov/40646704/","study_design":null,"title":"Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/associations-between-neuropsychiatric-symptoms-and-pathology-in-40084663","doi":"10.1177/13872877251320670","journal":"Journal of Alzheimer s Disease","n_participants":75,"pmid":"40084663","source_url":"https://pubmed.ncbi.nlm.nih.gov/40084663/","study_design":null,"title":"Associations between neuropsychiatric symptoms and pathology in clinicopathologically defined Alzheimer's disease, Alzheimer's disease with Lewy bodies, and dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/current-strategies-in-the-management-of-dementia-with-lewy-bodies-and-40598239","doi":"10.1186/s13024-025-00856-7","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"40598239","source_url":"https://pubmed.ncbi.nlm.nih.gov/40598239/","study_design":null,"title":"Current strategies in the management of dementia with lewy bodies and future directions based on disease pathophysiology","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/distinct-subcellular-localization-of-tau-and-alpha-synuclein-in-lewy-39838428","doi":"10.1186/s40478-024-01913-w","journal":"Acta Neuropathologica Communications","n_participants":null,"pmid":"39838428","source_url":"https://pubmed.ncbi.nlm.nih.gov/39838428/","study_design":null,"title":"Distinct subcellular localization of tau and alpha-synuclein in lewy body disease","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/elevated-cerebrospinal-fluid-synuclein-seeding-activity-predicts-39817492","doi":"10.1002/mdc3.14333","journal":"Movement Disorders Clinical Practice","n_participants":null,"pmid":"39817492","source_url":"https://pubmed.ncbi.nlm.nih.gov/39817492/","study_design":"longitudinal study","title":"Elevated Cerebrospinal Fluid \u03b1\u2010Synuclein Seeding Activity Predicts Central Lewy Body Diseases","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/tracer-kinetic-model-detecting-heterogeneous-bloodbrain-barrier-39936244","doi":"10.1002/alz.14529","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"39936244","source_url":"https://pubmed.ncbi.nlm.nih.gov/39936244/","study_design":null,"title":"Tracer kinetic model detecting heterogeneous blood\u2013brain barrier permeability to water and contrast agent in Alzheimer's disease and dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/a-common-outcome-set-for-trials-in-dementia-with-lewy-bodies-dlb-cos-40657378","doi":"10.1002/trc2.70134","journal":"Alzheimer s & Dementia Translational Research & Clinical Interventions","n_participants":null,"pmid":"40657378","source_url":"https://pubmed.ncbi.nlm.nih.gov/40657378/","study_design":"systematic review","title":"A common outcome set for trials in dementia with Lewy bodies (DLB COS)","title_match":true,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/substantia-nigra-iron-deposition-in-lewy-body-disease-a-magnetic-40545947","doi":"10.1002/mds.30265","journal":"Movement Disorders","n_participants":13,"pmid":"40545947","source_url":"https://pubmed.ncbi.nlm.nih.gov/40545947/","study_design":"cohort study","title":"Substantia Nigra Iron Deposition in Lewy Body Disease: A Magnetic Resonance Imaging and Neuropathology Study","title_match":true,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/a-quantitative-dopa-decarboxylase-biomarker-for-diagnosis-in-lewy-41699128","doi":"10.1038/s41591-026-04212-0","journal":"Nature Medicine","n_participants":740,"pmid":"41699128","source_url":"https://pubmed.ncbi.nlm.nih.gov/41699128/","study_design":null,"title":"A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/parkinsonism-in-alzheimer-s-disease-without-lewy-bodies-in-40042515","doi":"10.1002/alz.14628","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40042515","source_url":"https://pubmed.ncbi.nlm.nih.gov/40042515/","study_design":null,"title":"Parkinsonism in Alzheimer's disease without Lewy bodies in association with nigral neuron loss: A data\u2010driven clinicopathologic study","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genomewide-association-analysis-identifies-apoe-as-a-mitophagy-40309932","doi":"10.1002/alz.70198","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40309932","source_url":"https://pubmed.ncbi.nlm.nih.gov/40309932/","study_design":null,"title":"Genome\u2010wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/lewy-body-dementia-exploring-biomarkers-and-pathogenic-interactions-40797227","doi":"10.1186/s13024-025-00879-0","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"40797227","source_url":"https://pubmed.ncbi.nlm.nih.gov/40797227/","study_design":null,"title":"Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid \u03b2, tau, and \u03b1-synuclein","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/peripheral-singlecell-immune-characteristics-contribute-to-the-39754303","doi":"10.1111/cns.70204","journal":"CNS Neuroscience & Therapeutics","n_participants":null,"pmid":"39754303","source_url":"https://pubmed.ncbi.nlm.nih.gov/39754303/","study_design":null,"title":"Peripheral Single\u2010Cell Immune Characteristics Contribute to the Diagnosis of Alzheimer's Disease and Dementia With Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-40748123","doi":"10.1212/cont.0000000000001604","journal":"CONTINUUM Lifelong Learning in Neurology","n_participants":null,"pmid":"40748123","source_url":"https://pubmed.ncbi.nlm.nih.gov/40748123/","study_design":null,"title":"Dementia With Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/safety-cognitive-and-behavioral-outcomes-in-patients-with-dementia-40565990","doi":"10.3390/jcm14124245","journal":"Journal of Clinical Medicine","n_participants":43,"pmid":"40565990","source_url":"https://pubmed.ncbi.nlm.nih.gov/40565990/","study_design":"clinical trial","title":"Safety, Cognitive, and Behavioral Outcomes in Patients with Dementia with Lewy Bodies Treated with Nilotinib","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/lewy-bodies-are-not-associated-with-neuronal-or-synaptic-loss-in-42270085","doi":"10.1111/nan.70085","journal":"Neuropathology and Applied Neurobiology","n_participants":20,"pmid":"42270085","source_url":"https://pubmed.ncbi.nlm.nih.gov/42270085/","study_design":null,"title":"Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/quantitative-susceptibility-mapping-reveals-differences-between-40904193","doi":"10.1093/brain/awaf325","journal":"Brain","n_participants":66,"pmid":"40904193","source_url":"https://pubmed.ncbi.nlm.nih.gov/40904193/","study_design":null,"title":"Quantitative susceptibility mapping reveals differences between subtypes of Lewy body dementia","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/autonomic-dysfunction-in-patients-with-dementia-with-lewy-bodies-and-40112273","doi":"10.1212/wnl.0000000000213463","journal":"Neurology","n_participants":null,"pmid":"40112273","source_url":"https://pubmed.ncbi.nlm.nih.gov/40112273/","study_design":"cohort study","title":"Autonomic Dysfunction in Patients With Dementia With Lewy Bodies and Its Relationship With Nigrostriatal Denervation","title_match":true,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/neuropsychological-and-clinical-indicators-of-lewy-body-and-alzheimer-40034524","doi":"10.1177/25424823241304386","journal":"Journal of Alzheimer s Disease Reports","n_participants":null,"pmid":"40034524","source_url":"https://pubmed.ncbi.nlm.nih.gov/40034524/","study_design":null,"title":"Neuropsychological and clinical indicators of Lewy body and Alzheimer's pathology","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/evidence-for-divergent-cortical-organisation-in-parkinsons-disease-41290734","doi":"10.1038/s41467-025-66783-9","journal":"Nature Communications","n_participants":108,"pmid":"41290734","source_url":"https://pubmed.ncbi.nlm.nih.gov/41290734/","study_design":null,"title":"Evidence for divergent cortical organisation in Parkinson\u2019s disease and Lewy Body Dementia","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-neuropathological-features-in-lewy-40091616","doi":"10.1093/brain/awaf105","journal":"Brain","n_participants":980,"pmid":"40091616","source_url":"https://pubmed.ncbi.nlm.nih.gov/40091616/","study_design":null,"title":"Genome-wide association study of neuropathological features in Lewy body disease","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/synaptic-vesicle-endocytosis-deficits-underlie-cognitive-dysfunction-41006254","doi":"10.1038/s41467-025-63444-9","journal":"Nature Communications","n_participants":null,"pmid":"41006254","source_url":"https://pubmed.ncbi.nlm.nih.gov/41006254/","study_design":null,"title":"Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson\u2019s disease and dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/quantitative-electroencephalography-in-the-diagnosis-of-dementia-with-40687078","doi":"10.1016/j.cnp.2025.06.008","journal":"Clinical Neurophysiology Practice","n_participants":null,"pmid":"40687078","source_url":"https://pubmed.ncbi.nlm.nih.gov/40687078/","study_design":null,"title":"Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/neural-basis-of-anxiety-in-dementia-with-lewy-bodies-40899733","doi":"10.1002/gps.70150","journal":"International Journal of Geriatric Psychiatry","n_participants":40,"pmid":"40899733","source_url":"https://pubmed.ncbi.nlm.nih.gov/40899733/","study_design":null,"title":"Neural Basis of Anxiety in Dementia With Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-ptau217-and-a42-40-as-markers-of-a-pathology-in-the-lewy-body-41075284","doi":"10.1002/alz.70788","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41075284","source_url":"https://pubmed.ncbi.nlm.nih.gov/41075284/","study_design":null,"title":"Plasma p\u2010tau217 and A\u03b242/40 as markers of A\u03b2 pathology in the Lewy body continuum","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/impact-of-hippocampal-synuclein-oligomers-on-cognitive-trajectory-in-40755115","doi":"10.1002/alz.70374","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40755115","source_url":"https://pubmed.ncbi.nlm.nih.gov/40755115/","study_design":null,"title":"Impact of hippocampal \u03b1\u2010synuclein oligomers on cognitive trajectory in patients with dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/blood-synuclein-separates-parkinson-s-disease-from-dementia-with-lewy-40521808","doi":"10.1002/ana.27288","journal":"Annals of Neurology","n_participants":null,"pmid":"40521808","source_url":"https://pubmed.ncbi.nlm.nih.gov/40521808/","study_design":null,"title":"Blood \u03b1\u2010Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/hospice-use-among-medicare-beneficiaries-with-parkinson-disease-and-40036035","doi":"10.1001/jamanetworkopen.2025.0014","journal":"JAMA Network Open","n_participants":null,"pmid":"40036035","source_url":"https://pubmed.ncbi.nlm.nih.gov/40036035/","study_design":"cohort study","title":"Hospice Use Among Medicare Beneficiaries With Parkinson Disease and Dementia With Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neuroimaging-of-psychosis-agitation-and-affective-disturbance-in-40107929","doi":"10.1016/j.inpsyc.2025.100059","journal":"International Psychogeriatrics","n_participants":180,"pmid":"40107929","source_url":"https://pubmed.ncbi.nlm.nih.gov/40107929/","study_design":null,"title":"Neuroimaging of psychosis, agitation, and affective disturbance in Alzheimer\u2019s disease, dementia with Lewy bodies, and mild cognitive impairment","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/lewy-body-dementia-research-in-latin-america-a-scoping-review-40256832","doi":"10.1002/mdc3.70059","journal":"Movement Disorders Clinical Practice","n_participants":null,"pmid":"40256832","source_url":"https://pubmed.ncbi.nlm.nih.gov/40256832/","study_design":"cohort study","title":"Lewy Body Dementia Research in Latin America: A Scoping Review","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/identifying-gait-differences-between-alzheimer-s-disease-and-dementia-39868511","doi":"10.1002/alz.14351","journal":"Alzheimer s & Dementia","n_participants":420,"pmid":"39868511","source_url":"https://pubmed.ncbi.nlm.nih.gov/39868511/","study_design":null,"title":"Identifying gait differences between Alzheimer's disease and dementia with Lewy bodies and their associations with regional amyloid deposition","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/sex-differences-in-prodromal-dementia-with-lewy-bodies-using-the-40390234","doi":"10.1002/alz.70275","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40390234","source_url":"https://pubmed.ncbi.nlm.nih.gov/40390234/","study_design":"longitudinal study","title":"Sex differences in prodromal dementia with Lewy bodies using the National Alzheimer's Coordinating Center data","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/key-motor-and-non-motor-features-in-early-dementia-with-lewy-bodies-40183012","doi":"10.3389/fneur.2025.1555175","journal":"Frontiers in Neurology","n_participants":107,"pmid":"40183012","source_url":"https://pubmed.ncbi.nlm.nih.gov/40183012/","study_design":"cross-sectional","title":"Key motor and non-motor features in early dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/visual-hallucinations-in-serotonergic-psychedelics-and-lewy-body-41051875","doi":"10.1093/schbul/sbaf068","journal":"Schizophrenia Bulletin","n_participants":null,"pmid":"41051875","source_url":"https://pubmed.ncbi.nlm.nih.gov/41051875/","study_design":"narrative review","title":"Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/sex-differences-for-regional-pathology-in-people-with-a-high-39886324","doi":"10.1002/dad2.70083","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":357,"pmid":"39886324","source_url":"https://pubmed.ncbi.nlm.nih.gov/39886324/","study_design":null,"title":"Sex differences for regional pathology in people with a high likelihood of Lewy body dementia phenotype based on underlying pathology","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/preclinical-catecholaminergic-biomarkers-of-central-lewy-body-diseases-41517809","doi":"10.3988/jcn.2025.0629","journal":"Journal of Clinical Neurology","n_participants":null,"pmid":"41517809","source_url":"https://pubmed.ncbi.nlm.nih.gov/41517809/","study_design":"longitudinal study","title":"Preclinical Catecholaminergic Biomarkers of Central Lewy Body Diseases","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/depression-preceding-and-following-the-diagnosis-of-parkinsons-41362287","doi":"10.1136/gpsych-2025-102405","journal":"General Psychiatry","n_participants":711,"pmid":"41362287","source_url":"https://pubmed.ncbi.nlm.nih.gov/41362287/","study_design":"case-control study","title":"Depression preceding and following the diagnosis of Parkinson\u2019s disease and Lewy body dementia","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/copathology-in-alzheimer-s-disease-and-lewy-body-disease-and-its-40951924","doi":"10.1002/alz.70693","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40951924","source_url":"https://pubmed.ncbi.nlm.nih.gov/40951924/","study_design":null,"title":"Co\u2010pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cerebrovascular-co-pathology-and-cholinergic-white-matter-pathways-40391186","doi":"10.1093/braincomms/fcaf173","journal":"Brain Communications","n_participants":82,"pmid":"40391186","source_url":"https://pubmed.ncbi.nlm.nih.gov/40391186/","study_design":null,"title":"Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/dopaminergic-changes-in-the-subgenual-cingulate-cortex-in-dementia-40113786","doi":"10.1038/s41398-025-03298-3","journal":"Translational Psychiatry","n_participants":null,"pmid":"40113786","source_url":"https://pubmed.ncbi.nlm.nih.gov/40113786/","study_design":null,"title":"Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/early-functional-changes-in-lewy-body-dementia-roles-of-dynamics-40849483","doi":"10.1186/s13195-025-01828-1","journal":"Alzheimer s Research & Therapy","n_participants":39,"pmid":"40849483","source_url":"https://pubmed.ncbi.nlm.nih.gov/40849483/","study_design":null,"title":"Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/intrinsic-capacity-in-patients-with-dementia-with-lewy-bodies-40121962","doi":"10.1016/j.jnha.2025.100541","journal":"The journal of nutrition health & aging","n_participants":798,"pmid":"40121962","source_url":"https://pubmed.ncbi.nlm.nih.gov/40121962/","study_design":"cross-sectional","title":"Intrinsic capacity in patients with dementia with Lewy bodies compared with those with Alzheimer\u2019s disease: A cross-sectional study","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/phase-2-study-of-zervimesine-ct1812-in-participants-with-41416579","doi":"10.1002/alz.71004","journal":"Alzheimer s & Dementia","n_participants":293,"pmid":"41416579","source_url":"https://pubmed.ncbi.nlm.nih.gov/41416579/","study_design":null,"title":"Phase 2 study of zervimesine (CT1812) in participants with mild\u2010to\u2010moderate dementia with Lewy bodies (DLB)","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-association-between-plasma-and-mri-biomarkers-in-dementia-with-40847319","doi":"10.1186/s13195-025-01848-x","journal":"Alzheimer s Research & Therapy","n_participants":92,"pmid":"40847319","source_url":"https://pubmed.ncbi.nlm.nih.gov/40847319/","study_design":null,"title":"The association between plasma and MRI biomarkers in dementia with lewy bodies","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/brain-network-connectivity-underlying-neuropsychiatric-symptoms-in-40267731","doi":"10.1016/j.neurobiolaging.2025.04.007","journal":"Neurobiology of Aging","n_participants":28,"pmid":"40267731","source_url":"https://pubmed.ncbi.nlm.nih.gov/40267731/","study_design":null,"title":"Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/implication-of-dopamine-transporter-and-electroencephalography-41120550","doi":"10.1038/s41598-025-20587-5","journal":"Scientific Reports","n_participants":120,"pmid":"41120550","source_url":"https://pubmed.ncbi.nlm.nih.gov/41120550/","study_design":null,"title":"Implication of dopamine transporter and electroencephalography biomarkers in dementia with lewy bodies","title_match":true,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/alice-in-wonderland-syndrome-in-dementia-with-lewy-bodies-a-case-40212614","doi":"10.3389/fneur.2025.1556218","journal":"Frontiers in Neurology","n_participants":null,"pmid":"40212614","source_url":"https://pubmed.ncbi.nlm.nih.gov/40212614/","study_design":null,"title":"Alice in Wonderland Syndrome in dementia with Lewy bodies: a case report exploring visual cognition dysfunction","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/progression-of-clinical-diagnostic-features-and-cognitive-decline-in-40552972","doi":"10.1017/s0033291725100895","journal":"Psychological Medicine","n_participants":74,"pmid":"40552972","source_url":"https://pubmed.ncbi.nlm.nih.gov/40552972/","study_design":"cohort study","title":"Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-disease-prognosis-in-mild-cognitive-impairment-40156325","doi":"10.1002/mds.30181","journal":"Movement Disorders","n_participants":131,"pmid":"40156325","source_url":"https://pubmed.ncbi.nlm.nih.gov/40156325/","study_design":"longitudinal study","title":"Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/disease-progression-from-mild-cognitive-impairment-to-dementia-for-40655923","doi":"10.1177/25424823251359541","journal":"Journal of Alzheimer s Disease Reports","n_participants":null,"pmid":"40655923","source_url":"https://pubmed.ncbi.nlm.nih.gov/40655923/","study_design":null,"title":"Disease progression from mild cognitive impairment to dementia for patients with Alzheimer's disease or Lewy body pathology","title_match":true,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/evaluating-the-impact-of-age-and-treatment-on-neuroinflammation-40992617","doi":"10.1016/j.expneurol.2025.115475","journal":"Experimental Neurology","n_participants":null,"pmid":"40992617","source_url":"https://pubmed.ncbi.nlm.nih.gov/40992617/","study_design":null,"title":"Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/spinal-cord-tau-and-protein-copathologies-associated-with-chronic-41587040","doi":"10.1001/jamaneurol.2025.5421","journal":"JAMA Neurology","n_participants":14,"pmid":"41587040","source_url":"https://pubmed.ncbi.nlm.nih.gov/41587040/","study_design":"case-control study","title":"Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy","title_match":false,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/in-silico-structure-based-multi-targeted-molecular-docking-analysis-8d167666","doi":"10.1016/j.insi.2026.100411","journal":"In Silico Research in Biomedicine","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.insi.2026.100411","study_design":null,"title":"In silico structure-based multi-targeted molecular docking analysis of ginkgo biloba phytocompounds against Alzheimer\u2019s disease associated proteins","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-seed-aggregation-assay-and-alzheimer-biomarkers-41511749","doi":"10.1002/alz70856_107531","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41511749","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12787306/","study_design":"longitudinal study","title":"Cerebrospinal fluid seed aggregation assay and Alzheimer biomarkers in a Dementia with Lewy Body cohort","title_match":true,"year":2025},{"alzhub_score":29,"alzhub_url":"https://alzhub.org/study/identification-and-functional-verification-of-new-molecular-targets-8bd743a7","doi":"10.26262/heal.auth.ir.369671","journal":"Aristotle University of Thessaloniki","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.26262/heal.auth.ir.369671","study_design":null,"title":"Identification and functional verification of new molecular targets of blood \u2013 cerebrospinal fluid and exosomes from patients with neurodegenerative diseases","title_match":false,"year":2026},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/normal-pressure-hydrocephalus-combined-with-quadruple-misfolded-39921653","doi":"10.1093/jnen/nlaf006","journal":"Journal of Neuropathology & Experimental Neurology","n_participants":50,"pmid":"39921653","source_url":"https://pubmed.ncbi.nlm.nih.gov/39921653/","study_design":"cohort study","title":"Normal pressure hydrocephalus combined with quadruple misfolded proteinopathy: An autopsy case report and a short review of literature","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/glp-1-receptor-agonists-reduce-dementia-and-alzheimer-disease-risk-in-41697144","doi":"10.1093/ndt/gfag032","journal":"Nephrology Dialysis Transplantation","n_participants":null,"pmid":"41697144","source_url":"https://pubmed.ncbi.nlm.nih.gov/41697144/","study_design":"cohort study","title":"GLP-1 receptor agonists reduce dementia and Alzheimer disease risk in diabetic patients with CKD","title_match":false,"year":2026},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/glp-1-receptor-agonists-reduce-dementia-and-alzheimer-disease-risk-in-01baa622","doi":"10.1681/asn.2025rdy8v05v","journal":"Journal of the American Society of Nephrology","n_participants":12351,"pmid":null,"source_url":"https://doi.org/10.1681/asn.2025rdy8v05v","study_design":"cohort study","title":"GLP-1 Receptor Agonists Reduce Dementia and Alzheimer Disease Risk in Patients with Diabetes and Advanced CKD: Real-World Evidence from TriNetX","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/gait-characteristics-and-factors-associated-with-fall-risk-in-41069430","doi":"10.3389/fneur.2025.1670016","journal":"Frontiers in Neurology","n_participants":63,"pmid":"41069430","source_url":"https://pubmed.ncbi.nlm.nih.gov/41069430/","study_design":"cross-sectional","title":"Gait characteristics and factors associated with fall risk in patients with dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/effectiveness-of-acetylcholinesterase-inhibitors-and-memantine-in-41396413","doi":"10.1007/s11357-025-02052-3","journal":"GeroScience","n_participants":703,"pmid":"41396413","source_url":"https://pubmed.ncbi.nlm.nih.gov/41396413/","study_design":null,"title":"Effectiveness of acetylcholinesterase inhibitors and memantine in patients affected by severe dementia","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/evaluation-of-cerebrospinal-fluid-levels-of-vamp-2-and-snap-25-in-a-39994784","doi":"10.1186/s13195-025-01685-y","journal":"Alzheimer s Research & Therapy","n_participants":62,"pmid":"39994784","source_url":"https://pubmed.ncbi.nlm.nih.gov/39994784/","study_design":null,"title":"Evaluation of cerebrospinal fluid levels of VAMP-2 and SNAP-25 in a dementia with Lewy bodies clinical cohort stratified by Alzheimer\u2019s pathophysiological biomarkers","title_match":true,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/dysfunctional-default-mode-and-visual-networks-underlie-cognitive-41346435","doi":"10.3389/fnagi.2025.1630826","journal":"Frontiers in Aging Neuroscience","n_participants":null,"pmid":"41346435","source_url":"https://pubmed.ncbi.nlm.nih.gov/41346435/","study_design":null,"title":"Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/association-between-visual-hallucinations-and-cognitive-performance-40330106","doi":"10.1177/25424823251339132","journal":"Journal of Alzheimer s Disease Reports","n_participants":154,"pmid":"40330106","source_url":"https://pubmed.ncbi.nlm.nih.gov/40330106/","study_design":null,"title":"Association between visual hallucinations and cognitive performance in Lewy body dementia and Alzheimer's disease: A cross-sectional study","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-benson-complex-figure-test-for-the-differential-diagnosis-of-41874041","doi":"10.3390/neurosci7020038","journal":"NeuroSci","n_participants":1428,"pmid":"41874041","source_url":"https://pubmed.ncbi.nlm.nih.gov/41874041/","study_design":"cross-sectional","title":"The Benson Complex Figure Test for the Differential Diagnosis of Dementias","title_match":false,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/prevalence-and-correlates-of-the-head-turning-sign-in-mild-cognitive-39956974","doi":"10.1177/13872877251318011","journal":"Journal of Alzheimer s Disease","n_participants":121,"pmid":"39956974","source_url":"https://pubmed.ncbi.nlm.nih.gov/39956974/","study_design":null,"title":"Prevalence and correlates of the head turning sign in mild cognitive impairment and dementia due to neurodegenerative, chronic cerebrovascular, and mixed etiologies","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/delineation-of-the-cognitive-and-neuropsychiatric-features-of-pisa-41346438","doi":"10.3389/fnagi.2025.1637930","journal":"Frontiers in Aging Neuroscience","n_participants":35,"pmid":"41346438","source_url":"https://pubmed.ncbi.nlm.nih.gov/41346438/","study_design":"longitudinal study","title":"Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/limited-diagnostic-performance-of-cerebrospinal-fluid-glial-41557565","doi":"10.1159/000550601","journal":"Dementia and Geriatric Cognitive Disorders","n_participants":1345,"pmid":"41557565","source_url":"https://pubmed.ncbi.nlm.nih.gov/41557565/","study_design":"cohort study","title":"Limited Diagnostic Performance of Cerebrospinal Fluid Glial Fibrillary Acidic Protein in Dementia","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/potential-role-of-amyloid-on-the-association-between-orexin-a-and-40457423","doi":"10.1186/s13195-025-01770-2","journal":"Alzheimer s Research & Therapy","n_participants":25,"pmid":"40457423","source_url":"https://pubmed.ncbi.nlm.nih.gov/40457423/","study_design":null,"title":"Potential role of Amyloid-\u03b2 on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer\u2019s disease and dementia with lewy bodies","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-head-turning-sign-outside-the-clinic-walls-in-patients-with-mild-42179083","doi":"10.1177/13872877261452271","journal":"Journal of Alzheimer s Disease","n_participants":71,"pmid":"42179083","source_url":"https://pubmed.ncbi.nlm.nih.gov/42179083/","study_design":"retrospective cohort","title":"The head turning sign \u201coutside the clinic walls\u201d in patients with mild cognitive impairment and dementia","title_match":false,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/representing-the-cognitive-impairment-continuum-of-alzheimer-s-41442571","doi":"10.1002/alz70856_102179","journal":"Alzheimer s & Dementia","n_participants":106,"pmid":"41442571","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12735618/","study_design":null,"title":"Representing the Cognitive Impairment Continuum of Alzheimer's Disease and Lewy Body Dementia with a Novel Finer\u2010Scale Cortical Representation via Disease Embedding Tree","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-yes-no-reversal-phenomenon-prevalence-and-correlates-in-mild-41660964","doi":"10.1177/13872877261418686","journal":"Journal of Alzheimer s Disease","n_participants":267,"pmid":"41660964","source_url":"https://pubmed.ncbi.nlm.nih.gov/41660964/","study_design":null,"title":"The yes-no reversal phenomenon: Prevalence and correlates in mild cognitive impairment and dementia due to neurodegenerative, chronic cerebrovascular, and mixed etiologies","title_match":false,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/towards-optimizing-the-diagnosis-of-lewy-body-dementia-lessons-from-41117431","doi":"10.1002/alz.70794","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41117431","source_url":"https://pubmed.ncbi.nlm.nih.gov/41117431/","study_design":null,"title":"Towards optimizing the diagnosis of Lewy body dementia: Lessons from the NACC","title_match":true,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/the-bidirectional-association-of-epilepsy-with-alzheimer-s-disease-42135610","doi":"10.1177/13872877261450962","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"42135610","source_url":"https://pubmed.ncbi.nlm.nih.gov/42135610/","study_design":null,"title":"The bidirectional association of epilepsy with Alzheimer's disease and other neurodegenerative dementias: A longitudinal observational study on the UK Biobank","title_match":false,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/development-of-18f-aci-19626-as-a-first-in-class-brain-pet-tracer-for-41136425","doi":"10.1038/s41467-025-64540-6","journal":"Nature Communications","n_participants":null,"pmid":"41136425","source_url":"https://pubmed.ncbi.nlm.nih.gov/41136425/","study_design":null,"title":"Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/cerebral-amyloid-angiopathy-in-patients-with-dementia-with-lewy-40479839","doi":"10.1016/j.parkreldis.2025.107892","journal":"Parkinsonism & Related Disorders","n_participants":null,"pmid":"40479839","source_url":"https://pubmed.ncbi.nlm.nih.gov/40479839/","study_design":null,"title":"Cerebral amyloid angiopathy in patients with Dementia with Lewy Bodies: A clinical and hippocampal morphology study","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/iatrogenic-cerebral-proteinopathiesthe-dawn-of-transmissible-41281549","doi":"10.3389/fneur.2025.1693566","journal":"Frontiers in Neurology","n_participants":125,"pmid":"41281549","source_url":"https://pubmed.ncbi.nlm.nih.gov/41281549/","study_design":null,"title":"Iatrogenic cerebral proteinopathies\u2014The dawn of transmissible neurodegeneration? The example of cerebral amyloid angiopathy","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/tdp-43-pathology-is-associated-with-divergent-protein-profiles-in-als-40826370","doi":"10.1186/s40478-025-02084-y","journal":"Acta Neuropathologica Communications","n_participants":16,"pmid":"40826370","source_url":"https://pubmed.ncbi.nlm.nih.gov/40826370/","study_design":null,"title":"TDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/an-acetylated-tau-174-csf-biomarker-discriminates-between-tdp-43-and-41986736","doi":"10.1038/s41591-026-04341-6","journal":"Nature Medicine","n_participants":513,"pmid":"41986736","source_url":"https://pubmed.ncbi.nlm.nih.gov/41986736/","study_design":null,"title":"An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration","title_match":false,"year":2026},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/tdp-43-proteinopathy-the-complex-biological-and-clinical-findings-in-40709644","doi":"10.1097/yco.0000000000001027","journal":"Current Opinion in Psychiatry","n_participants":null,"pmid":"40709644","source_url":"https://pubmed.ncbi.nlm.nih.gov/40709644/","study_design":null,"title":"TDP-43 proteinopathy: the complex biological and clinical findings in LATE-NC, LANS, and other mixed age-related major neurocognitive disorders","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-dementia-and-depression-in-older-adults-41682879","doi":"10.3390/jcm15031198","journal":"Journal of Clinical Medicine","n_participants":null,"pmid":"41682879","source_url":"https://pubmed.ncbi.nlm.nih.gov/41682879/","study_design":"cohort study","title":"Cognitive Impairment, Dementia and Depression in Older Adults","title_match":false,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/neuropathologic-correlates-of-seizures-in-patients-with-alzheimer-42385113","doi":"10.1212/wnl.0000000000218277","journal":"Neurology","n_participants":null,"pmid":"42385113","source_url":"https://pubmed.ncbi.nlm.nih.gov/42385113/","study_design":"cohort study","title":"Neuropathologic Correlates of Seizures in Patients With Alzheimer Disease and Dementia With Lewy Bodies","title_match":true,"year":2026},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/transactive-response-dna-binding-protein-43-tdp-43-proteinopathy-the-40709649","doi":"10.1097/yco.0000000000001025","journal":"Current Opinion in Psychiatry","n_participants":null,"pmid":"40709649","source_url":"https://pubmed.ncbi.nlm.nih.gov/40709649/","study_design":null,"title":"Transactive response DNA-binding protein 43 (TDP-43) proteinopathy: the complex biological and clinical findings in limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes, limbic-predominant amnestic neurodegenerative syndrome, and other mixed age-related major neurocognitive disorders","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/amyloid-tau-protein-synuclein-tdp-43-and-fus-in-mixed-pathology-and-42074305","doi":"10.3390/ijms27083669","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"42074305","source_url":"https://pubmed.ncbi.nlm.nih.gov/42074305/","study_design":null,"title":"Amyloid-\u03b2, Tau Protein, \u03b1-Synuclein, TDP-43, and FUS in Mixed Pathology: And Intrinsic Disorder to Rule Them All","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/pathological-synuclein-dysregulates-epitranscriptomic-writer-mettl3-40279247","doi":"10.1016/j.celrep.2025.115618","journal":"Cell Reports","n_participants":null,"pmid":"40279247","source_url":"https://pubmed.ncbi.nlm.nih.gov/40279247/","study_design":null,"title":"Pathological \u03b1-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/potential-targets-of-microglia-in-the-treatment-of-neurodegenerative-40145977","doi":"10.4103/nrr.nrr-d-24-01343","journal":"Neural Regeneration Research","n_participants":null,"pmid":"40145977","source_url":"https://pubmed.ncbi.nlm.nih.gov/40145977/","study_design":null,"title":"Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/single-nucleus-transcriptomics-reveals-a-distinct-microglial-state-40826098","doi":"10.1186/s13073-025-01519-4","journal":"Genome Medicine","n_participants":null,"pmid":"40826098","source_url":"https://pubmed.ncbi.nlm.nih.gov/40826098/","study_design":null,"title":"Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/shared-neuroinflammatory-mechanisms-across-dementia-types-an-41516057","doi":"10.3390/ijms27010179","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"41516057","source_url":"https://pubmed.ncbi.nlm.nih.gov/41516057/","study_design":null,"title":"Shared Neuroinflammatory Mechanisms Across Dementia Types: An Integrative Review","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/co-expression-of-mutant-tau-and-synuclein-in-neurons-promotes-tau-40707862","doi":"10.1007/s12035-025-05248-y","journal":"Molecular Neurobiology","n_participants":null,"pmid":"40707862","source_url":"https://pubmed.ncbi.nlm.nih.gov/40707862/","study_design":null,"title":"Co-Expression of Mutant Tau and \u03b1-Synuclein in Neurons Promotes Tau Phosphorylation, Neuronal Loss, and Neuroinflammation in Mouse Brain","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/csf-markers-of-neuroinflammation-synaptic-dysfunction-and-18f-dopa-40885039","doi":"10.1016/j.parkreldis.2025.108005","journal":"Parkinsonism & Related Disorders","n_participants":623,"pmid":"40885039","source_url":"https://pubmed.ncbi.nlm.nih.gov/40885039/","study_design":null,"title":"CSF markers of neuroinflammation, synaptic dysfunction and [18F]DOPA-PET in Parkinson's disease","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/distinct-and-combined-interferon-receptor-1-loss-in-neurons-and-42226039","doi":"10.1186/s12929-026-01257-8","journal":"Journal of Biomedical Science","n_participants":null,"pmid":"42226039","source_url":"https://pubmed.ncbi.nlm.nih.gov/42226039/","study_design":null,"title":"Distinct and combined interferon-\u0251/\u03b2-receptor-1 loss in neurons and astrocytes disrupt brain energy metabolism and drive Parkinsonian dementia","title_match":false,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/p2rx7-modulates-the-function-of-human-microglia-like-cells-and-40987420","doi":"10.1016/j.nbd.2025.107106","journal":"Neurobiology of Disease","n_participants":null,"pmid":"40987420","source_url":"https://pubmed.ncbi.nlm.nih.gov/40987420/","study_design":null,"title":"P2RX7 modulates the function of human microglia-like cells and mediates the association of IL18 with Alzheimer's disease traits","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/activated-microglial-exosomes-enhance-synuclein-internalization-and-41291718","doi":"10.1186/s12951-025-03838-5","journal":"Journal of Nanobiotechnology","n_participants":null,"pmid":"41291718","source_url":"https://pubmed.ncbi.nlm.nih.gov/41291718/","study_design":null,"title":"Activated microglial exosomes enhance \u03b1-Synuclein internalization and accelerate neurodegeneration in lewy body dementia","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/automated-imaging-differentiation-for-dementia-dd40034c","doi":"10.1212/wn9.0000000000000093","journal":"Neurology Open Access","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1212/wn9.0000000000000093","study_design":"cohort study","title":"Automated Imaging Differentiation for Dementia","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/molecular-crossroads-shared-and-divergent-molecular-signatures-in-41465242","doi":"10.3390/ijms262411811","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"41465242","source_url":"https://pubmed.ncbi.nlm.nih.gov/41465242/","study_design":null,"title":"Molecular Crossroads: Shared and Divergent Molecular Signatures in Alzheimer\u2019s Disease and Dementia with Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/detecting-amyloid-and-tau-pathology-in-parkinsons-disease-4r-40895094","doi":"10.3389/fneur.2025.1638852","journal":"Frontiers in Neurology","n_participants":18,"pmid":"40895094","source_url":"https://pubmed.ncbi.nlm.nih.gov/40895094/","study_design":null,"title":"Detecting amyloid and tau pathology in Parkinson\u2019s disease, 4R-tauopathies and control subjects with plasma pTau217","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/co-occurrence-of-multiple-pathologies-in-a-case-of-frontotemporal-40713844","doi":"10.1186/s40478-025-02081-1","journal":"Acta Neuropathologica Communications","n_participants":null,"pmid":"40713844","source_url":"https://pubmed.ncbi.nlm.nih.gov/40713844/","study_design":null,"title":"Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/influence-of-co-pathology-on-csf-and-plasma-synaptic-markers-snap25-40405270","doi":"10.1186/s13195-025-01762-2","journal":"Alzheimer s Research & Therapy","n_participants":80,"pmid":"40405270","source_url":"https://pubmed.ncbi.nlm.nih.gov/40405270/","study_design":null,"title":"Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer\u2019s disease and Parkinson\u2019s disease","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/brain-derived-tau-oligomer-polymorphs-distinct-aggregations-stability-39809992","doi":"10.1038/s42003-025-07499-w","journal":"Communications Biology","n_participants":null,"pmid":"39809992","source_url":"https://pubmed.ncbi.nlm.nih.gov/39809992/","study_design":null,"title":"Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/synuclein-and-tau-interactions-cross-seeding-and-the-redefinition-of-40212715","doi":"10.3389/fnins.2025.1570553","journal":"Frontiers in Neuroscience","n_participants":null,"pmid":"40212715","source_url":"https://pubmed.ncbi.nlm.nih.gov/40212715/","study_design":null,"title":"\u03b1-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/positron-emission-tomography-tracers-for-synucleinopathies-39757220","doi":"10.1186/s13024-024-00787-9","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"39757220","source_url":"https://pubmed.ncbi.nlm.nih.gov/39757220/","study_design":null,"title":"Positron emission tomography tracers for synucleinopathies","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/neurobiology-of-dementia-86818921","doi":"10.5742/mewfm.2025.805257903","journal":"World Family Medicine Journal/Middle East Journal of Family Medicine","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5742/mewfm.2025.805257903","study_design":null,"title":"Neurobiology of dementia","title_match":false,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/cell-type-and-tau-lesion-specific-accumulation-of-phospho-ser65-2d393b48","doi":"10.1186/s40478-026-02426-4","journal":"Acta Neuropathologica Communications","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1186/s40478-026-02426-4","study_design":null,"title":"Cell type- and tau lesion-specific accumulation of phospho-Ser65 ubiquitin in primary tauopathies","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/comorbid-neuropathologies-but-not-braak-stage-influence-cognitive-42215016","doi":"10.1093/jnen/nlag053","journal":"Journal of Neuropathology & Experimental Neurology","n_participants":174,"pmid":"42215016","source_url":"https://pubmed.ncbi.nlm.nih.gov/42215016/","study_design":"longitudinal study","title":"Comorbid neuropathologies but not Braak stage influence cognitive impairment in primary age-related tauopathy","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/single-cell-atlas-of-transcriptomic-vulnerability-across-brain-42778699","doi":"10.1038/s41586-025-09573-z","journal":"Nature","n_participants":null,"pmid":"42778699","source_url":"https://pubmed.ncbi.nlm.nih.gov/42778699/","study_design":null,"title":"Single-cell atlas of transcriptomic vulnerability across brain disorders","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-and-neurodegenerative-diseases-recent-advances-42505396","doi":"10.3390/cells15141287","journal":"Cells","n_participants":null,"pmid":"42505396","source_url":"https://pubmed.ncbi.nlm.nih.gov/42505396/","study_design":null,"title":"Mediterranean Diet and Neurodegenerative Diseases: Recent Advances from the Gut\u2013Immune\u2013Brain Axis to Multi-Omics-Guided Precision Nutrition","title_match":false,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/prevalence-timing-and-characteristics-of-delirium-preceding-dementia-40542850","doi":"10.1007/s00415-025-13193-y","journal":"Journal of Neurology","n_participants":null,"pmid":"40542850","source_url":"https://pubmed.ncbi.nlm.nih.gov/40542850/","study_design":null,"title":"Prevalence, timing and characteristics of delirium preceding dementia with Lewy bodies: a retrospective case series","title_match":true,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/sublingual-crushed-levodopa-for-parkinsons-disease-management-of-a-40585751","doi":"10.7759/cureus.85064","journal":"Cureus","n_participants":null,"pmid":"40585751","source_url":"https://pubmed.ncbi.nlm.nih.gov/40585751/","study_design":null,"title":"Sublingual Crushed Levodopa for Parkinson\u2019s Disease Management of a Lewy Body Dementia Patient With Dysphagia: A Case Report","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/validation-of-the-neuropathological-criteria-of-the-fourth-consortium-40162542","doi":"10.1111/pcn.13814","journal":"Psychiatry and Clinical Neurosciences","n_participants":null,"pmid":"40162542","source_url":"https://pubmed.ncbi.nlm.nih.gov/40162542/","study_design":null,"title":"Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals","title_match":true,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/domestic-violence-in-lewy-body-dementia-a-national-study-40084665","doi":"10.1177/13872877251325584","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40084665","source_url":"https://pubmed.ncbi.nlm.nih.gov/40084665/","study_design":null,"title":"Domestic violence in Lewy body dementia: A national study","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/safety-tolerability-and-potential-biomarkers-of-vodobatinib-in-40939527","doi":"10.1016/j.parkreldis.2025.108020","journal":"Parkinsonism & Related Disorders","n_participants":null,"pmid":"40939527","source_url":"https://pubmed.ncbi.nlm.nih.gov/40939527/","study_design":null,"title":"Safety, tolerability and potential biomarkers of vodobatinib in patients with dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/utilization-patterns-and-clinical-factors-associated-with-40611368","doi":"10.1002/gps.70125","journal":"International Journal of Geriatric Psychiatry","n_participants":175,"pmid":"40611368","source_url":"https://pubmed.ncbi.nlm.nih.gov/40611368/","study_design":null,"title":"Utilization Patterns and Clinical Factors Associated With Hospitalization in Early\u2010Stage Dementia With Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/seeing-the-trees-in-the-wood-the-importance-of-co-pathologies-in-40623303","doi":"10.1093/brain/awaf197","journal":"Brain","n_participants":85,"pmid":"40623303","source_url":"https://pubmed.ncbi.nlm.nih.gov/40623303/","study_design":"longitudinal study","title":"Seeing the trees in the wood: the importance of co-pathologies in Alzheimer\u2019s disease and dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/suffering-and-loss-in-lewy-body-dementia-applying-a-palliative-care-40538366","doi":"10.1017/s1478951524001962","journal":"Palliative & Supportive Care","n_participants":null,"pmid":"40538366","source_url":"https://pubmed.ncbi.nlm.nih.gov/40538366/","study_design":"longitudinal study","title":"Suffering and loss in Lewy body dementia: Applying a palliative care lens to a longitudinal narrative study","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/it-may-cost-you-your-money-it-costs-you-your-life-a-framework-for-40720566","doi":"10.1093/geront/gnaf170","journal":"The Gerontologist","n_participants":18,"pmid":"40720566","source_url":"https://pubmed.ncbi.nlm.nih.gov/40720566/","study_design":null,"title":"\u201cIt may cost you your money, it costs you your life\u201d: a framework for financial hardship in dementia","title_match":false,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/from-data-to-dialogue-in-setting-research-priorities-for-lewy-body-d983627d","doi":"10.1038/s44400-025-00019-x","journal":"npj Dementia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1038/s44400-025-00019-x","study_design":null,"title":"From data to dialogue in setting research priorities for Lewy body dementia","title_match":true,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/self-applied-single-channel-mastoid-exg-for-fully-automated-detection-ad526bca","doi":"10.64898/2026.08.14.26360475","journal":"medRxiv (preprint)","n_participants":378,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.14.26360475","study_design":"longitudinal study","title":"Self-applied single-channel mastoid ExG for fully automated detection of REM sleep behaviour disorder","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/impaired-cerebrovascular-cerebrospinal-fluid-coupling-is-associated-d2399b77","doi":"10.64898/2026.05.13.26353090","journal":"medRxiv (preprint)","n_participants":39,"pmid":null,"source_url":"https://doi.org/10.64898/2026.05.13.26353090","study_design":null,"title":"Impaired cerebrovascular-cerebrospinal fluid coupling is associated with non-motor features of Lewy body disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/gch1-genetic-variation-as-a-prognostic-factor-in-parkinsons-disease-a566b431","doi":"10.64898/2026.08.14.26359677","journal":"medRxiv (preprint)","n_participants":22825,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.14.26359677","study_design":"longitudinal study","title":"GCH1 genetic variation as a prognostic factor in Parkinsons disease across populations","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-large-language-model-extracted-gross-brain-f0890d90","doi":"10.64898/2026.09.12.26362866","journal":"medRxiv (preprint)","n_participants":5613,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.12.26362866","study_design":null,"title":"Diagnostic Value of Large Language Model-Extracted Gross Brain Findings in Neurodegenerative Diseases","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-associations-with-alzheimer-s-lewy-body-and-vascular-42a583d1","doi":"10.64898/2026.09.16.26362814","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.16.26362814","study_design":null,"title":"Genetic Associations with Alzheimer's, Lewy Body and Vascular Neuropathology Reveal Shared and Distinct Biological Pathways","title_match":true,"year":2026},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/analysis-of-japanese-nationwide-health-datasets-association-between-37439280","doi":"10.1515/sjpain-2023-0010","journal":"Scandinavian journal of pain","n_participants":null,"pmid":"37439280","source_url":"https://pubmed.ncbi.nlm.nih.gov/37439280/","study_design":null,"title":"Analysis of Japanese nationwide health datasets: association between lifestyle habits and prevalence of neuropathic pain and fibromyalgia with reference to dementia-related diseases and Parkinson's disease","title_match":false,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/neuropathology-of-older-persons-without-cognitive-impairment-from-two-16801647","doi":"10.1212/01.wnl.0000219668.47116.e6","journal":"Neurology","n_participants":2000,"pmid":"16801647","source_url":"https://pubmed.ncbi.nlm.nih.gov/16801647/","study_design":null,"title":"Neuropathology of older persons without cognitive impairment from two community-based studies","title_match":false,"year":2006},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/synaptic-vesicle-glycoprotein-2a-pet-imaging-in-parkinsonian-42704496","doi":"10.1007/s00415-026-14123-2","journal":"Journal of neurology","n_participants":null,"pmid":"42704496","source_url":"https://pubmed.ncbi.nlm.nih.gov/42704496/","study_design":"systematic review","title":"Synaptic vesicle glycoprotein 2A PET imaging in parkinsonian \u03b1-synucleinopathies: a systematic review","title_match":true,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/prevalence-and-clinical-associations-of-tau-in-lewy-body-dementias-a-33260030","doi":"10.1016/j.parkreldis.2020.09.030","journal":"Parkinsonism & related disorders","n_participants":1511,"pmid":"33260030","source_url":"https://pubmed.ncbi.nlm.nih.gov/33260030/","study_design":"meta-analysis","title":"Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis","title_match":true,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/mouse-closed-head-traumatic-brain-injury-replicates-the-histological-34187585","doi":"10.1186/s40478-021-01220-8","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"34187585","source_url":"https://pubmed.ncbi.nlm.nih.gov/34187585/","study_design":"systematic review","title":"Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature","title_match":false,"year":2021},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/biomarkers-of-neurodegeneration-and-glial-activation-validated-in-34618817","doi":"10.1371/journal.pone.0257372","journal":"PloS one","n_participants":null,"pmid":"34618817","source_url":"https://pubmed.ncbi.nlm.nih.gov/34618817/","study_design":"longitudinal study","title":"Biomarkers of neurodegeneration and glial activation validated in Alzheimer's disease assessed in longitudinal cerebrospinal fluid samples of Parkinson's disease","title_match":false,"year":2021},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/systematic-review-of-genetic-association-studies-in-people-with-lewy-31898332","doi":"10.1002/gps.5260","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"31898332","source_url":"https://pubmed.ncbi.nlm.nih.gov/31898332/","study_design":"systematic review","title":"Systematic review of genetic association studies in people with Lewy body dementia","title_match":true,"year":2020},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/a-systematic-review-to-evaluate-the-effect-of-neflamapimod-on-41510854","doi":"10.4103/neurol-india.neurol-india-d-25-00227","journal":"Neurology India","n_participants":null,"pmid":"41510854","source_url":"https://pubmed.ncbi.nlm.nih.gov/41510854/","study_design":"systematic review","title":"A Systematic Review to Evaluate the Effect of Neflamapimod on Cognitive Function and Progression of Dementia","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/systematic-review-of-differentially-abundant-proteins-in-people-with-40143552","doi":"10.1017/neu.2025.15","journal":"Acta neuropsychiatrica","n_participants":null,"pmid":"40143552","source_url":"https://pubmed.ncbi.nlm.nih.gov/40143552/","study_design":"systematic review","title":"Systematic review of differentially abundant proteins in people with Lewy body dementia","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/vagus-nerve-stimulation-in-the-management-of-neurodegenerative-41588887","doi":"10.2174/0115672050373772251103053036","journal":"Current Alzheimer research","n_participants":null,"pmid":"41588887","source_url":"https://pubmed.ncbi.nlm.nih.gov/41588887/","study_design":"systematic review","title":"Vagus Nerve Stimulation in the Management of Neurodegenerative Diseases: A Systematic Review of Advances in Animal Research and Clinical Applications","title_match":false,"year":2026},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/systematic-review-and-meta-analysis-of-human-transcriptomics-reveals-33347974","doi":"10.1016/j.nbd.2020.105225","journal":"Neurobiology of disease","n_participants":2600,"pmid":"33347974","source_url":"https://pubmed.ncbi.nlm.nih.gov/33347974/","study_design":"systematic review","title":"Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration","title_match":false,"year":2021},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/possible-association-between-pm-sub-2-5-sub-and-neurodegenerative-34979121","doi":"10.1016/j.envres.2021.112581","journal":"Environmental research","n_participants":20,"pmid":"34979121","source_url":"https://pubmed.ncbi.nlm.nih.gov/34979121/","study_design":"systematic review","title":"Possible association between PM2.5 and neurodegenerative diseases: A systematic review","title_match":false,"year":2022},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/systematic-review-of-gene-expression-studies-in-people-with-lewy-body-32178745","doi":"10.1017/neu.2020.13","journal":"Acta neuropsychiatrica","n_participants":null,"pmid":"32178745","source_url":"https://pubmed.ncbi.nlm.nih.gov/32178745/","study_design":"systematic review","title":"Systematic review of gene expression studies in people with Lewy body dementia","title_match":true,"year":2020},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/in-vivo-tau-pet-imaging-in-dementia-pathophysiology-radiotracer-28315409","doi":"10.1016/j.arr.2017.03.002","journal":"Ageing research reviews","n_participants":null,"pmid":"28315409","source_url":"https://pubmed.ncbi.nlm.nih.gov/28315409/","study_design":"systematic review","title":"In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings","title_match":false,"year":2017},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/synuclein-in-lewy-bodies-9278044","doi":"10.1038/42166","journal":"Nature","n_participants":null,"pmid":"9278044","source_url":"https://pubmed.ncbi.nlm.nih.gov/9278044/","study_design":null,"title":"\u03b1-Synuclein in Lewy bodies","title_match":true,"year":1997},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/criteria-for-the-diagnosis-of-corticobasal-degeneration-23359374","doi":"10.1212/wnl.0b013e31827f0fd1","journal":"Neurology","n_participants":null,"pmid":"23359374","source_url":"https://pubmed.ncbi.nlm.nih.gov/23359374/","study_design":null,"title":"Criteria for the diagnosis of corticobasal degeneration","title_match":false,"year":2013},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/accuracy-of-clinical-diagnosis-of-idiopathic-parkinson-s-disease-a-1564476","doi":"10.1136/jnnp.55.3.181","journal":"Journal of Neurology Neurosurgery & Psychiatry","n_participants":null,"pmid":"1564476","source_url":"https://pubmed.ncbi.nlm.nih.gov/1564476/","study_design":null,"title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.","title_match":false,"year":1992},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/mutation-in-the-synuclein-gene-identified-in-families-with-parkinson-9197268","doi":"10.1126/science.276.5321.2045","journal":"Science","n_participants":null,"pmid":"9197268","source_url":"https://pubmed.ncbi.nlm.nih.gov/9197268/","study_design":null,"title":"Mutation in the \u03b1-Synuclein Gene Identified in Families with Parkinson's Disease","title_match":true,"year":1997},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-sydney-multicenter-study-of-parkinson-s-disease-the-inevitability-18307261","doi":"10.1002/mds.21956","journal":"Movement Disorders","n_participants":null,"pmid":"18307261","source_url":"https://pubmed.ncbi.nlm.nih.gov/18307261/","study_design":null,"title":"The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/lewy-bodies-in-alzheimer-s-disease-a-neuropathological-review-of-145-10885656","doi":"10.1111/j.1750-3639.2000.tb00269.x","journal":"Brain Pathology","n_participants":null,"pmid":"10885656","source_url":"https://pubmed.ncbi.nlm.nih.gov/10885656/","study_design":null,"title":"Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using \u03b1\u2010Synuclein Immunohistochemistry","title_match":true,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/distinguishing-alzheimer-s-disease-from-other-major-forms-of-dementia-22014137","doi":"10.1586/ern.11.155","journal":"Expert review of neurotherapeutics","n_participants":null,"pmid":"22014137","source_url":"https://pubmed.ncbi.nlm.nih.gov/22014137/","study_design":null,"title":"Distinguishing Alzheimer's disease from other major forms of dementia","title_match":false,"year":2011},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-14693108","doi":"10.1016/s1474-4422(03)00619-7","journal":"The Lancet. Neurology","n_participants":null,"pmid":"14693108","source_url":"https://pubmed.ncbi.nlm.nih.gov/14693108/","study_design":null,"title":"Dementia with Lewy bodies","title_match":true,"year":2004},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/lrrk2-expression-in-normal-and-pathologic-human-brain-and-in-human-17021400","doi":"10.1097/01.jnen.0000235121.98052.54","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"17021400","source_url":"https://pubmed.ncbi.nlm.nih.gov/17021400/","study_design":null,"title":"LRRK2 expression in normal and pathologic human brain and in human cell lines","title_match":false,"year":2006},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/immunotherapy-targeting-toll-like-receptor-2-alleviates-30092810","doi":"10.1186/s13024-018-0276-2","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"30092810","source_url":"https://pubmed.ncbi.nlm.nih.gov/30092810/","study_design":null,"title":"Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating \u03b1-synuclein transmission and neuroinflammation","title_match":true,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/glial-dysfunction-in-the-pathogenesis-of-synucleinopathies-emerging-21562886","doi":"10.1007/s00401-011-0833-z","journal":"Acta neuropathologica","n_participants":null,"pmid":"21562886","source_url":"https://pubmed.ncbi.nlm.nih.gov/21562886/","study_design":null,"title":"Glial dysfunction in the pathogenesis of \u03b1-synucleinopathies: emerging concepts","title_match":true,"year":2011},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/glucocerebrosidase-activity-modulates-neuronal-susceptibility-to-31899072","doi":"10.1016/j.neuron.2019.12.004","journal":"Neuron","n_participants":null,"pmid":"31899072","source_url":"https://pubmed.ncbi.nlm.nih.gov/31899072/","study_design":null,"title":"Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological \u03b1-Synuclein Insult","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/sustained-systemic-glucocerebrosidase-inhibition-induces-brain-26094487","doi":"10.1089/ars.2015.6307","journal":"Antioxidants & redox signaling","n_participants":null,"pmid":"26094487","source_url":"https://pubmed.ncbi.nlm.nih.gov/26094487/","study_design":null,"title":"Sustained Systemic Glucocerebrosidase Inhibition Induces Brain \u03b1-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice","title_match":true,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/glial-fibrillar-acidic-protein-in-the-cerebrospinal-fluid-of-26485083","doi":"10.1111/jnc.13399","journal":"Journal of neurochemistry","n_participants":null,"pmid":"26485083","source_url":"https://pubmed.ncbi.nlm.nih.gov/26485083/","study_design":null,"title":"Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration","title_match":true,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-stimulation-of-astrocytes-potential-role-for-20972375","doi":"10.4161/oxim.3.4.12809","journal":"Oxidative medicine and cellular longevity","n_participants":null,"pmid":"20972375","source_url":"https://pubmed.ncbi.nlm.nih.gov/20972375/","study_design":null,"title":"Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection","title_match":true,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/exosome-associated-tau-is-secreted-in-tauopathy-models-and-is-22057275","doi":"10.1074/jbc.m111.277061","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"22057275","source_url":"https://pubmed.ncbi.nlm.nih.gov/22057275/","study_design":null,"title":"Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/presynaptic-alpha-synuclein-aggregates-not-lewy-bodies-cause-17287515","doi":"10.1523/jneurosci.4564-06.2007","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"17287515","source_url":"https://pubmed.ncbi.nlm.nih.gov/17287515/","study_design":null,"title":"Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies","title_match":true,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-pathologic-cascade-leading-to-synaptic-dysfunction-in-alpha-20554859","doi":"10.1523/jneurosci.1091-10.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"20554859","source_url":"https://pubmed.ncbi.nlm.nih.gov/20554859/","study_design":null,"title":"A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration","title_match":true,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/emerging-histomorphologic-phenotypes-of-chronic-traumatic-21358359","doi":"10.1227/neu.0b013e318212bc7b","journal":"Neurosurgery","n_participants":null,"pmid":"21358359","source_url":"https://pubmed.ncbi.nlm.nih.gov/21358359/","study_design":null,"title":"Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes","title_match":false,"year":2011},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/synuclein-interacts-with-prp-sup-c-sup-to-induce-cognitive-impairment-28945221","doi":"10.1038/nn.4648","journal":"Nature neuroscience","n_participants":null,"pmid":"28945221","source_url":"https://pubmed.ncbi.nlm.nih.gov/28945221/","study_design":null,"title":"\u03b1-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B","title_match":true,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/beta-amyloid-deposition-in-chronic-traumatic-encephalopathy-25943889","doi":"10.1007/s00401-015-1435-y","journal":"Acta neuropathologica","n_participants":114,"pmid":"25943889","source_url":"https://pubmed.ncbi.nlm.nih.gov/25943889/","study_design":null,"title":"Beta-amyloid deposition in chronic traumatic encephalopathy","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/synaptic-markers-of-cognitive-decline-in-neurodegenerative-diseases-a-29324989","doi":"10.1093/brain/awx352","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"29324989","source_url":"https://pubmed.ncbi.nlm.nih.gov/29324989/","study_design":null,"title":"Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/interface-between-tauopathies-and-synucleinopathies-a-tale-of-two-16489609","doi":"10.1002/ana.20819","journal":"Annals of neurology","n_participants":null,"pmid":"16489609","source_url":"https://pubmed.ncbi.nlm.nih.gov/16489609/","study_design":null,"title":"Interface between tauopathies and synucleinopathies: a tale of two proteins","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-in-lewy-body-disease-and-alzheimer-s-disease-10517509","doi":"10.1111/j.1750-3639.1999.tb00552.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"10517509","source_url":"https://pubmed.ncbi.nlm.nih.gov/10517509/","study_design":null,"title":"Alpha-synuclein in Lewy body disease and Alzheimer's disease","title_match":true,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/elevated-tauopathy-and-alpha-synuclein-pathology-in-postmortem-20599975","doi":"10.1016/j.expneurol.2010.06.017","journal":"Experimental neurology","n_participants":null,"pmid":"20599975","source_url":"https://pubmed.ncbi.nlm.nih.gov/20599975/","study_design":null,"title":"Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia","title_match":true,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/brain-fluorodeoxyglucose-fdg-pet-in-dementia-26876244","doi":"10.1016/j.arr.2016.02.003","journal":"Ageing research reviews","n_participants":null,"pmid":"26876244","source_url":"https://pubmed.ncbi.nlm.nih.gov/26876244/","study_design":null,"title":"Brain fluorodeoxyglucose (FDG) PET in dementia","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/altered-proteins-in-the-aging-brain-26979082","doi":"10.1093/jnen/nlw002","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"26979082","source_url":"https://pubmed.ncbi.nlm.nih.gov/26979082/","study_design":null,"title":"Altered Proteins in the Aging Brain","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/pathologic-accumulation-of-synuclein-and-a-in-parkinson-disease-22825369","doi":"10.1001/archneurol.2012.1608","journal":"Archives of neurology","n_participants":null,"pmid":"22825369","source_url":"https://pubmed.ncbi.nlm.nih.gov/22825369/","study_design":null,"title":"Pathologic accumulation of \u03b1-synuclein and A\u03b2 in Parkinson disease patients with dementia","title_match":true,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/pathologic-findings-in-prospectively-ascertained-essential-tremor-18413570","doi":"10.1212/01.wnl.0000310425.76205.02","journal":"Neurology","n_participants":null,"pmid":"18413570","source_url":"https://pubmed.ncbi.nlm.nih.gov/18413570/","study_design":null,"title":"Pathologic findings in prospectively ascertained essential tremor subjects","title_match":false,"year":2008},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/synaptic-proteins-predict-cognitive-decline-in-alzheimer-s-disease-27224930","doi":"10.1016/j.jalz.2016.04.005","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":129,"pmid":"27224930","source_url":"https://pubmed.ncbi.nlm.nih.gov/27224930/","study_design":null,"title":"Synaptic proteins predict cognitive decline in Alzheimer's disease and\u00a0Lewy body dementia","title_match":true,"year":2016},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-neurogranin-concentration-in-neurodegeneration-29700597","doi":"10.1007/s00401-018-1851-x","journal":"Acta neuropathologica","n_participants":915,"pmid":"29700597","source_url":"https://pubmed.ncbi.nlm.nih.gov/29700597/","study_design":null,"title":"Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology","title_match":false,"year":2018},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-synuclein-pathology-and-related-toxicity-32024798","doi":"10.1126/scitranslmed.aay1809","journal":"Science translational medicine","n_participants":null,"pmid":"32024798","source_url":"https://pubmed.ncbi.nlm.nih.gov/32024798/","study_design":null,"title":"APOE4 exacerbates \u03b1-synuclein pathology and related toxicity independent of amyloid","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/sup-18-sup-f-fdg-pet-imaging-in-neurodegenerative-dementing-disorders-35649653","doi":"10.2967/jnumed.121.263194","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":null,"pmid":"35649653","source_url":"https://pubmed.ncbi.nlm.nih.gov/35649653/","study_design":null,"title":"18F-FDG PET Imaging in Neurodegenerative Dementing Disorders: Insights into Subtype Classification, Emerging Disease Categories, and Mixed Dementia with Copathologies","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/incidence-and-extent-of-lewy-body-related-alpha-synucleinopathy-in-18957894","doi":"10.1097/nen.0b013e31818b4126","journal":"Journal of neuropathology and experimental neurology","n_participants":102,"pmid":"18957894","source_url":"https://pubmed.ncbi.nlm.nih.gov/18957894/","study_design":null,"title":"Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb","title_match":true,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-of-alzheimer-s-disease-current-33578866","doi":"10.3390/brainsci11020215","journal":"Brain sciences","n_participants":null,"pmid":"33578866","source_url":"https://pubmed.ncbi.nlm.nih.gov/33578866/","study_design":null,"title":"Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: Current Evidence and Future Perspectives","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/hyperphosphorylated-tau-in-an-synuclein-overexpressing-transgenic-21453448","doi":"10.1111/j.1460-9568.2011.07660.x","journal":"The European journal of neuroscience","n_participants":null,"pmid":"21453448","source_url":"https://pubmed.ncbi.nlm.nih.gov/21453448/","study_design":null,"title":"Hyperphosphorylated Tau in an \u03b1-synuclein-overexpressing transgenic model of Parkinson's disease","title_match":true,"year":2011},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/lipid-and-immune-abnormalities-causing-age-dependent-31331333","doi":"10.1186/s12974-019-1532-2","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"31331333","source_url":"https://pubmed.ncbi.nlm.nih.gov/31331333/","study_design":null,"title":"Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/rapidly-progressive-neurodegenerative-dementias-19204156","doi":"10.1001/archneurol.2008.534","journal":"Archives of neurology","n_participants":96,"pmid":"19204156","source_url":"https://pubmed.ncbi.nlm.nih.gov/19204156/","study_design":null,"title":"Rapidly progressive neurodegenerative dementias","title_match":false,"year":2009},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/123i-mibg-cardiac-scintigraphy-provides-clues-to-the-underlying-18517041","doi":"10.1093/sleep/31.5.717","journal":"Sleep","n_participants":95,"pmid":"18517041","source_url":"https://pubmed.ncbi.nlm.nih.gov/18517041/","study_design":"cross-sectional","title":"123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder","title_match":false,"year":2008},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/abi3-and-plcg2-missense-variants-as-risk-factors-for-30326945","doi":"10.1186/s13024-018-0289-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"30326945","source_url":"https://pubmed.ncbi.nlm.nih.gov/30326945/","study_design":"case-control study","title":"ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans","title_match":false,"year":2018},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/outcomes-after-diagnosis-of-mild-cognitive-impairment-in-a-large-28224671","doi":"10.1002/ana.24903","journal":"Annals of neurology","n_participants":1337,"pmid":"28224671","source_url":"https://pubmed.ncbi.nlm.nih.gov/28224671/","study_design":null,"title":"Outcomes after diagnosis of mild cognitive impairment in a large autopsy series","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/oligomeropathies-and-pathogenesis-of-alzheimer-and-parkinson-s-27030592","doi":"10.1002/mds.26624","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"27030592","source_url":"https://pubmed.ncbi.nlm.nih.gov/27030592/","study_design":null,"title":"Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/synuclein-oligomers-induce-glutamate-release-from-astrocytes-and-33483428","doi":"10.1523/jneurosci.1871-20.2020","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"33483428","source_url":"https://pubmed.ncbi.nlm.nih.gov/33483428/","study_design":null,"title":"\u03b1-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss","title_match":true,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-including-focal-presentations-30925614","doi":"10.1055/s-0039-1681041","journal":"Seminars in neurology","n_participants":null,"pmid":"30925614","source_url":"https://pubmed.ncbi.nlm.nih.gov/30925614/","study_design":null,"title":"Alzheimer's Disease Including Focal Presentations","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/what-features-improve-the-accuracy-of-the-clinical-diagnosis-of-20108379","doi":"10.1002/mds.22977","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":444,"pmid":"20108379","source_url":"https://pubmed.ncbi.nlm.nih.gov/20108379/","study_design":null,"title":"What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy-parkinsonism (PSP-P)?","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/basal-forebrain-cholinergic-system-in-the-dementias-vulnerability-34272732","doi":"10.1111/jnc.15471","journal":"Journal of neurochemistry","n_participants":null,"pmid":"34272732","source_url":"https://pubmed.ncbi.nlm.nih.gov/34272732/","study_design":null,"title":"Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/tau-is-required-for-progressive-synaptic-and-memory-deficits-in-a-31168644","doi":"10.1007/s00401-019-02032-w","journal":"Acta neuropathologica","n_participants":null,"pmid":"31168644","source_url":"https://pubmed.ncbi.nlm.nih.gov/31168644/","study_design":null,"title":"Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of \u03b1-synucleinopathy","title_match":true,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/biochemical-staging-of-synucleinopathy-and-amyloid-deposition-in-16651889","doi":"10.1097/01.jnen.0000205145.54457.ea","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"16651889","source_url":"https://pubmed.ncbi.nlm.nih.gov/16651889/","study_design":null,"title":"Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies","title_match":true,"year":2006},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/sensitivity-and-specificity-of-a-seed-amplification-assay-for-39577923","doi":"10.1016/s1474-4422(24)00395-8","journal":"The Lancet. Neurology","n_participants":80,"pmid":"39577923","source_url":"https://pubmed.ncbi.nlm.nih.gov/39577923/","study_design":"cohort study","title":"Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/a-peculiar-constellation-of-tau-pathology-defines-a-subset-of-21437732","doi":"10.1007/s00401-011-0819-x","journal":"Acta neuropathologica","n_participants":null,"pmid":"21437732","source_url":"https://pubmed.ncbi.nlm.nih.gov/21437732/","study_design":"longitudinal study","title":"A peculiar constellation of tau pathology defines a subset of dementia in the elderly","title_match":false,"year":2011},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/familial-amyotrophic-lateral-sclerosis-and-parkinsonism-dementia-11310628","doi":"10.1002/ana.100","journal":"Annals of neurology","n_participants":null,"pmid":"11310628","source_url":"https://pubmed.ncbi.nlm.nih.gov/11310628/","study_design":null,"title":"Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan: clinical and neuropathological study and tau analysis","title_match":false,"year":2001},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/reduced-synaptic-density-in-patients-with-lewy-body-dementia-an-sup-33899255","doi":"10.1002/mds.28617","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":21,"pmid":"33899255","source_url":"https://pubmed.ncbi.nlm.nih.gov/33899255/","study_design":null,"title":"Reduced Synaptic Density in Patients with Lewy Body Dementia: An [11 C]UCB-J PET Imaging Study","title_match":true,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-inclusions-in-amygdala-in-the-brains-of-patients-with-10901229","doi":"10.1093/jnen/59.7.585","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"10901229","source_url":"https://pubmed.ncbi.nlm.nih.gov/10901229/","study_design":null,"title":"Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam","title_match":true,"year":2000},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/lewy-body-disease-or-diseases-with-lewy-bodies-35013341","doi":"10.1038/s41531-021-00273-9","journal":"NPJ Parkinson's disease","n_participants":null,"pmid":"35013341","source_url":"https://pubmed.ncbi.nlm.nih.gov/35013341/","study_design":null,"title":"Lewy body disease or diseases with Lewy bodies?","title_match":true,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/predictors-of-cognitive-impairment-in-primary-age-related-tauopathy-34353357","doi":"10.1186/s40478-021-01233-3","journal":"Acta neuropathologica communications","n_participants":174,"pmid":"34353357","source_url":"https://pubmed.ncbi.nlm.nih.gov/34353357/","study_design":null,"title":"Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/role-of-synucleins-in-alzheimer-s-disease-19551456","doi":"10.1007/s12640-009-9073-6","journal":"Neurotoxicity research","n_participants":null,"pmid":"19551456","source_url":"https://pubmed.ncbi.nlm.nih.gov/19551456/","study_design":null,"title":"Role of synucleins in Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-in-parkinson-s-disease-and-dementia-with-lewy-26411499","doi":"10.1016/j.parkreldis.2015.09.034","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"26411499","source_url":"https://pubmed.ncbi.nlm.nih.gov/26411499/","study_design":null,"title":"Cognitive impairment in Parkinson's disease and dementia with Lewy bodies","title_match":true,"year":2016},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/clinical-practice-with-anti-dementia-drugs-a-consensus-statement-from-17060346","doi":"10.1177/0269881106068299","journal":"Journal of psychopharmacology (Oxford, England)","n_participants":null,"pmid":"17060346","source_url":"https://pubmed.ncbi.nlm.nih.gov/17060346/","study_design":"meta-analysis","title":"Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology","title_match":false,"year":2006},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/hydroxytyrosol-decreases-lps-and-synuclein-induced-microglial-31906130","doi":"10.3390/antiox9010036","journal":"Antioxidants (Basel, Switzerland)","n_participants":null,"pmid":"31906130","source_url":"https://pubmed.ncbi.nlm.nih.gov/31906130/","study_design":null,"title":"Hydroxytyrosol Decreases LPS- and \u03b1-Synuclein-Induced Microglial Activation In Vitro","title_match":true,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-is-associated-with-a-lower-probability-of-36692092","doi":"10.1111/ene.15698","journal":"European journal of neurology","n_participants":21,"pmid":"36692092","source_url":"https://pubmed.ncbi.nlm.nih.gov/36692092/","study_design":"longitudinal study","title":"Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study","title_match":true,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-brainstem-pathologies-of-parkinson-s-disease-and-dementia-with-24995389","doi":"10.1111/bpa.12168","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"24995389","source_url":"https://pubmed.ncbi.nlm.nih.gov/24995389/","study_design":null,"title":"The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies","title_match":true,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuropathology-of-dementia-in-parkinson-s-disease-a-prospective-16240351","doi":"10.1002/ana.20635","journal":"Annals of neurology","n_participants":18,"pmid":"16240351","source_url":"https://pubmed.ncbi.nlm.nih.gov/16240351/","study_design":null,"title":"Neuropathology of dementia in Parkinson's disease: a prospective, community-based study","title_match":false,"year":2005},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/progression-of-dysarthria-and-dysphagia-in-postmortem-confirmed-11176964","doi":"10.1001/archneur.58.2.259","journal":"Archives of neurology","n_participants":17,"pmid":"11176964","source_url":"https://pubmed.ncbi.nlm.nih.gov/11176964/","study_design":null,"title":"Progression of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders","title_match":false,"year":2001},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/accuracy-of-clinical-criteria-for-the-diagnosis-of-progressive-8780065","doi":"10.1212/wnl.46.4.922","journal":"Neurology","n_participants":24,"pmid":"8780065","source_url":"https://pubmed.ncbi.nlm.nih.gov/8780065/","study_design":null,"title":"Accuracy of clinical criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome)","title_match":false,"year":1996},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-interplay-of-cholinergic-function-attention-and-falls-in-21898597","doi":"10.1002/mds.23932","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"21898597","source_url":"https://pubmed.ncbi.nlm.nih.gov/21898597/","study_design":null,"title":"The interplay of cholinergic function, attention, and falls in Parkinson's disease","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/acetylcholine-and-hallucinations-disease-related-compared-to-drug-8546852","doi":"10.1006/brcg.1995.1255","journal":"Brain and cognition","n_participants":null,"pmid":"8546852","source_url":"https://pubmed.ncbi.nlm.nih.gov/8546852/","study_design":null,"title":"Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness","title_match":false,"year":1995},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/treatment-of-autonomic-dysfunction-in-parkinson-disease-and-other-29508455","doi":"10.1002/mds.27344","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"29508455","source_url":"https://pubmed.ncbi.nlm.nih.gov/29508455/","study_design":null,"title":"Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-differential-diagnosis-and-treatment-of-atypical-parkinsonism-26900156","doi":"10.3238/arztebl.2016.0061","journal":"Deutsches Arzteblatt international","n_participants":null,"pmid":"26900156","source_url":"https://pubmed.ncbi.nlm.nih.gov/26900156/","study_design":null,"title":"The Differential Diagnosis and Treatment of Atypical Parkinsonism","title_match":false,"year":2016},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-diagnosis-of-delirium-superimposed-on-dementia-an-emerging-27650668","doi":"10.1016/j.jamda.2016.07.014","journal":"Journal of the American Medical Directors Association","n_participants":null,"pmid":"27650668","source_url":"https://pubmed.ncbi.nlm.nih.gov/27650668/","study_design":null,"title":"The Diagnosis of Delirium Superimposed on Dementia: An Emerging Challenge","title_match":false,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/clinical-and-quantitative-pathologic-correlates-of-dementia-with-lewy-10522886","doi":"10.1212/wnl.53.6.1284","journal":"Neurology","n_participants":25,"pmid":"10522886","source_url":"https://pubmed.ncbi.nlm.nih.gov/10522886/","study_design":null,"title":"Clinical and quantitative pathologic correlates of dementia with Lewy bodies","title_match":true,"year":1999},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/predictors-of-falls-and-fractures-in-bradykinetic-rigid-syndromes-a-16543524","doi":"10.1136/jnnp.2005.074070","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"16543524","source_url":"https://pubmed.ncbi.nlm.nih.gov/16543524/","study_design":null,"title":"Predictors of falls and fractures in bradykinetic rigid syndromes: a retrospective study","title_match":false,"year":2006},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/diffuse-lewy-body-disease-and-progressive-dementia-2843793","doi":"10.1212/wnl.38.10.1520","journal":"Neurology","n_participants":null,"pmid":"2843793","source_url":"https://pubmed.ncbi.nlm.nih.gov/2843793/","study_design":null,"title":"Diffuse Lewy body disease and progressive dementia","title_match":true,"year":1988},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/the-impact-of-autonomic-dysfunction-on-survival-in-patients-with-23049679","doi":"10.1371/journal.pone.0045451","journal":"PloS one","n_participants":36,"pmid":"23049679","source_url":"https://pubmed.ncbi.nlm.nih.gov/23049679/","study_design":"longitudinal study","title":"The impact of autonomic dysfunction on survival in patients with dementia with Lewy bodies and Parkinson's disease with dementia","title_match":true,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/which-clinical-features-differentiate-progressive-supranuclear-palsy-9055798","doi":"10.1093/brain/120.1.65","journal":"Brain : a journal of neurology","n_participants":24,"pmid":"9055798","source_url":"https://pubmed.ncbi.nlm.nih.gov/9055798/","study_design":null,"title":"Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study","title_match":false,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/progression-of-falls-in-postmortem-confirmed-parkinsonian-disorders-10584668","doi":"10.1002/1531-8257(199911)14:6<947::aid-mds1006>3.0.co;2-o","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"10584668","source_url":"https://pubmed.ncbi.nlm.nih.gov/10584668/","study_design":null,"title":"Progression of falls in postmortem-confirmed parkinsonian disorders","title_match":false,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/characterization-of-hydrophobic-residue-requirements-for-alpha-19722699","doi":"10.1021/bi900539p","journal":"Biochemistry","n_participants":null,"pmid":"19722699","source_url":"https://pubmed.ncbi.nlm.nih.gov/19722699/","study_design":null,"title":"Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization","title_match":true,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/prodromal-clinical-manifestations-of-neuropathologically-confirmed-19026468","doi":"10.1016/j.neurobiolaging.2008.09.017","journal":"Neurobiology of aging","n_participants":null,"pmid":"19026468","source_url":"https://pubmed.ncbi.nlm.nih.gov/19026468/","study_design":null,"title":"Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease","title_match":true,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/behavioral-and-psychologic-symptoms-in-different-types-of-dementia-16877235","doi":"10.1016/s0929-6646(09)60150-9","journal":"Journal of the Formosan Medical Association = Taiwan yi zhi","n_participants":137,"pmid":"16877235","source_url":"https://pubmed.ncbi.nlm.nih.gov/16877235/","study_design":null,"title":"Behavioral and psychologic symptoms in different types of dementia","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-comparison-of-sleep-profiles-in-patients-with-dementia-with-lewy-11113983","doi":"10.1002/1099-1166(200011)15:11<1028::aid-gps227>3.0.co;2-e","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"11113983","source_url":"https://pubmed.ncbi.nlm.nih.gov/11113983/","study_design":null,"title":"A comparison of sleep profiles in patients with dementia with lewy bodies and Alzheimer's disease","title_match":true,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/revisiting-dlb-diagnosis-a-consideration-of-prodromal-dlb-and-of-the-27502299","doi":"10.1177/0891988716656083","journal":"Journal of geriatric psychiatry and neurology","n_participants":null,"pmid":"27502299","source_url":"https://pubmed.ncbi.nlm.nih.gov/27502299/","study_design":null,"title":"Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease","title_match":true,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/beyond-the-synucleinopathies-alpha-synuclein-as-a-driving-force-in-31508228","doi":"10.1186/s40035-019-0172-x","journal":"Translational neurodegeneration","n_participants":null,"pmid":"31508228","source_url":"https://pubmed.ncbi.nlm.nih.gov/31508228/","study_design":null,"title":"Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/orthostatic-hypotension-and-rem-sleep-behaviour-disorder-impact-on-31142660","doi":"10.1136/jnnp-2019-320846","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"31142660","source_url":"https://pubmed.ncbi.nlm.nih.gov/31142660/","study_design":"meta-analysis","title":"Orthostatic hypotension and REM sleep behaviour disorder: impact on clinical outcomes in \u03b1-synucleinopathies","title_match":true,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/stress-and-burden-among-caregivers-of-patients-with-lewy-body-dementia-20667944","doi":"10.1093/geront/gnq055","journal":"The Gerontologist","n_participants":611,"pmid":"20667944","source_url":"https://pubmed.ncbi.nlm.nih.gov/20667944/","study_design":null,"title":"Stress and burden among caregivers of patients with Lewy body dementia","title_match":true,"year":2011},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/dietary-polyphenols-a-multifactorial-strategy-to-target-alzheimer-s-31615073","doi":"10.3390/ijms20205090","journal":"International journal of molecular sciences","n_participants":null,"pmid":"31615073","source_url":"https://pubmed.ncbi.nlm.nih.gov/31615073/","study_design":null,"title":"Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/comorbidity-in-dementia-update-of-an-ongoing-autopsy-study-25039832","doi":"10.1111/jgs.12977","journal":"Journal of the American Geriatrics Society","n_participants":86,"pmid":"25039832","source_url":"https://pubmed.ncbi.nlm.nih.gov/25039832/","study_design":"cohort study","title":"Comorbidity in dementia: update of an ongoing autopsy study","title_match":false,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cause-of-death-and-end-of-life-experiences-in-individuals-with-30291740","doi":"10.1111/jgs.15608","journal":"Journal of the American Geriatrics Society","n_participants":658,"pmid":"30291740","source_url":"https://pubmed.ncbi.nlm.nih.gov/30291740/","study_design":null,"title":"Cause of Death and End-of-Life Experiences in Individuals with Dementia with Lewy Bodies","title_match":true,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/graphene-quantum-dots-prevent-synucleinopathy-in-parkinson-s-disease-29988049","doi":"10.1038/s41565-018-0179-y","journal":"Nature nanotechnology","n_participants":null,"pmid":"29988049","source_url":"https://pubmed.ncbi.nlm.nih.gov/29988049/","study_design":null,"title":"Graphene quantum dots prevent \u03b1-synucleinopathy in Parkinson's disease","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/end-of-life-experiences-in-dementia-with-lewy-bodies-qualitative-31145749","doi":"10.1371/journal.pone.0217039","journal":"PloS one","n_participants":null,"pmid":"31145749","source_url":"https://pubmed.ncbi.nlm.nih.gov/31145749/","study_design":null,"title":"End-of-life experiences in dementia with Lewy bodies: Qualitative interviews with former caregivers","title_match":true,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/causes-and-outcomes-of-hospitalization-in-lewy-body-dementia-a-30930058","doi":"10.1016/j.parkreldis.2019.03.014","journal":"Parkinsonism & related disorders","n_participants":178,"pmid":"30930058","source_url":"https://pubmed.ncbi.nlm.nih.gov/30930058/","study_design":"cohort study","title":"Causes and outcomes of hospitalization in Lewy body dementia: A retrospective cohort study","title_match":true,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/caregiver-reported-barriers-to-quality-end-of-life-care-in-dementia-31902223","doi":"10.1177/1049909119897241","journal":"The American journal of hospice & palliative care","n_participants":null,"pmid":"31902223","source_url":"https://pubmed.ncbi.nlm.nih.gov/31902223/","study_design":null,"title":"Caregiver-Reported Barriers to Quality End-of-Life Care in Dementia With Lewy Bodies: A Qualitative Analysis","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-associated-with-limbic-and-neocortical-lewy-19889717","doi":"10.1093/brain/awp280","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"19889717","source_url":"https://pubmed.ncbi.nlm.nih.gov/19889717/","study_design":null,"title":"Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study","title_match":true,"year":2010},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/occipital-hypoperfusion-on-spect-in-dementia-with-lewy-bodies-but-not-11245717","doi":"10.1212/wnl.56.5.643","journal":"Neurology","n_participants":23,"pmid":"11245717","source_url":"https://pubmed.ncbi.nlm.nih.gov/11245717/","study_design":null,"title":"Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD","title_match":true,"year":2001},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/clinical-neuropathological-correlations-in-alzheimer-s-disease-and-8080388","doi":"10.1001/archneur.1994.00540210060013","journal":"Archives of neurology","n_participants":151,"pmid":"8080388","source_url":"https://pubmed.ncbi.nlm.nih.gov/8080388/","study_design":"cohort study","title":"Clinical-neuropathological correlations in Alzheimer's disease and related dementias","title_match":false,"year":1994},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/clinically-diagnosed-alzheimer-s-disease-autopsy-results-in-150-cases-3415200","doi":"10.1002/ana.410240110","journal":"Annals of neurology","n_participants":null,"pmid":"3415200","source_url":"https://pubmed.ncbi.nlm.nih.gov/3415200/","study_design":null,"title":"Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases","title_match":false,"year":1988},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/psychiatric-morbidity-in-dementia-with-lewy-bodies-a-prospective-10401449","doi":"10.1176/ajp.156.7.1039","journal":"The American journal of psychiatry","n_participants":null,"pmid":"10401449","source_url":"https://pubmed.ncbi.nlm.nih.gov/10401449/","study_design":null,"title":"Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer's disease","title_match":true,"year":1999},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/influence-of-comorbidities-in-idiopathic-normal-pressure-23758953","doi":"10.1186/2045-8118-10-22","journal":"Fluids and barriers of the CNS","n_participants":null,"pmid":"23758953","source_url":"https://pubmed.ncbi.nlm.nih.gov/23758953/","study_design":null,"title":"Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/total-and-phosphorylated-tau-protein-as-biological-markers-of-19853650","doi":"10.1016/j.exger.2009.10.010","journal":"Experimental gerontology","n_participants":null,"pmid":"19853650","source_url":"https://pubmed.ncbi.nlm.nih.gov/19853650/","study_design":null,"title":"Total and phosphorylated tau protein as biological markers of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-alzheimer-s-disease-in-relation-to-35195758","doi":"10.1007/s00401-022-02408-5","journal":"Acta neuropathologica","n_participants":null,"pmid":"35195758","source_url":"https://pubmed.ncbi.nlm.nih.gov/35195758/","study_design":null,"title":"Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change","title_match":false,"year":2022},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/differential-levels-of-plasma-biomarkers-of-neurodegeneration-in-lewy-35078917","doi":"10.1136/jnnp-2021-327788","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":300,"pmid":"35078917","source_url":"https://pubmed.ncbi.nlm.nih.gov/35078917/","study_design":"longitudinal study","title":"Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy","title_match":true,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-cutoffs-the-importance-of-coincident-neuropathological-22526019","doi":"10.1007/s00401-012-0983-7","journal":"Acta neuropathologica","n_participants":null,"pmid":"22526019","source_url":"https://pubmed.ncbi.nlm.nih.gov/22526019/","study_design":null,"title":"CSF biomarkers cutoffs: the importance of coincident neuropathological diseases","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-cerebrospinal-fluid-amyloid-beta42-40-ratio-in-the-20043812","doi":"10.2174/156720510791383796","journal":"Current Alzheimer research","n_participants":69,"pmid":"20043812","source_url":"https://pubmed.ncbi.nlm.nih.gov/20043812/","study_design":null,"title":"The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementia","title_match":false,"year":2010},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/differential-role-of-csf-fatty-acid-binding-protein-3-synuclein-and-28750675","doi":"10.1186/s13195-017-0276-4","journal":"Alzheimer's research & therapy","n_participants":48,"pmid":"28750675","source_url":"https://pubmed.ncbi.nlm.nih.gov/28750675/","study_design":null,"title":"Differential role of CSF fatty acid binding protein 3, \u03b1-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia","title_match":true,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/csf-neurofilament-proteins-in-the-differential-diagnosis-of-dementia-17314187","doi":"10.1136/jnnp.2006.107326","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"17314187","source_url":"https://pubmed.ncbi.nlm.nih.gov/17314187/","study_design":null,"title":"CSF neurofilament proteins in the differential diagnosis of dementia","title_match":false,"year":2007},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/differential-diagnostic-performance-of-a-panel-of-plasma-biomarkers-35603139","doi":"10.1002/dad2.12285","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":160,"pmid":"35603139","source_url":"https://pubmed.ncbi.nlm.nih.gov/35603139/","study_design":null,"title":"Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-in-blood-and-csf-as-marker-of-disease-27292537","doi":"10.1016/j.neuron.2016.05.018","journal":"Neuron","n_participants":null,"pmid":"27292537","source_url":"https://pubmed.ncbi.nlm.nih.gov/27292537/","study_design":null,"title":"Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/amyloid-beta-tau-synaptic-neurodegeneration-and-glial-biomarkers-in-32573951","doi":"10.1002/alz.12131","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"32573951","source_url":"https://pubmed.ncbi.nlm.nih.gov/32573951/","study_design":null,"title":"Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/a-panel-of-nine-cerebrospinal-fluid-biomarkers-may-identify-patients-25589779","doi":"10.1136/jnnp-2014-309562","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":31,"pmid":"25589779","source_url":"https://pubmed.ncbi.nlm.nih.gov/25589779/","study_design":"prospective cohort","title":"A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/comparative-analysis-of-cerebrospinal-fluid-biomarkers-in-the-26718584","doi":"10.1016/j.jalz.2015.10.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26718584","source_url":"https://pubmed.ncbi.nlm.nih.gov/26718584/","study_design":null,"title":"Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/levels-of-retinal-amyloid-correlate-with-levels-of-retinal-iapp-and-31884473","doi":"10.3233/jad-190868","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31884473","source_url":"https://pubmed.ncbi.nlm.nih.gov/31884473/","study_design":null,"title":"Levels of Retinal Amyloid-\u03b2 Correlate with Levels of Retinal IAPP and Hippocampal Amyloid-\u03b2 in Neuropathologically Evaluated Individuals","title_match":false,"year":2020},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/neuronally-derived-extracellular-vesicle-synuclein-as-a-serum-38048087","doi":"10.1001/jamaneurol.2023.4398","journal":"JAMA neurology","n_participants":170,"pmid":"38048087","source_url":"https://pubmed.ncbi.nlm.nih.gov/38048087/","study_design":"cross-sectional","title":"Neuronally Derived Extracellular Vesicle \u03b1-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/raman-spectroscopy-to-diagnose-alzheimer-s-disease-and-dementia-with-29865787","doi":"10.1021/acschemneuro.8b00198","journal":"ACS chemical neuroscience","n_participants":null,"pmid":"29865787","source_url":"https://pubmed.ncbi.nlm.nih.gov/29865787/","study_design":null,"title":"Raman Spectroscopy to Diagnose Alzheimer's Disease and Dementia with Lewy Bodies in Blood","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/biofluid-based-biomarkers-for-alzheimer-s-disease-related-pathologies-35213777","doi":"10.1002/alz.12618","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35213777","source_url":"https://pubmed.ncbi.nlm.nih.gov/35213777/","study_design":null,"title":"Biofluid-based biomarkers for Alzheimer's disease-related pathologies: An update and synthesis of the literature","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/utility-of-different-mr-modalities-in-mild-cognitive-impairment-and-18692749","doi":"10.1016/j.acra.2008.04.008","journal":"Academic radiology","n_participants":54,"pmid":"18692749","source_url":"https://pubmed.ncbi.nlm.nih.gov/18692749/","study_design":"longitudinal study","title":"Utility of different MR modalities in mild cognitive impairment and its use as a predictor of conversion to probable dementia","title_match":false,"year":2008},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/development-of-an-ultra-high-sensitive-immunoassay-with-plasma-27278241","doi":"10.1186/s12951-016-0198-5","journal":"Journal of nanobiotechnology","n_participants":null,"pmid":"27278241","source_url":"https://pubmed.ncbi.nlm.nih.gov/27278241/","study_design":null,"title":"Development of an ultra-high sensitive immunoassay with plasma biomarker for differentiating Parkinson disease dementia from Parkinson disease using antibody functionalized magnetic nanoparticles","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/a-longitudinal-study-of-plasma-ptau181-in-mild-cognitive-impairment-35318733","doi":"10.1002/mds.28994","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"35318733","source_url":"https://pubmed.ncbi.nlm.nih.gov/35318733/","study_design":"longitudinal study","title":"A Longitudinal Study of Plasma pTau181 in Mild Cognitive Impairment with Lewy Bodies and Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/novel-blood-test-for-early-biomarkers-of-preeclampsia-and-alzheimer-s-34354200","doi":"10.1038/s41598-021-95611-5","journal":"Scientific reports","n_participants":33,"pmid":"34354200","source_url":"https://pubmed.ncbi.nlm.nih.gov/34354200/","study_design":null,"title":"Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/detection-of-oligomeric-forms-of-alpha-synuclein-protein-in-human-16507759","doi":"10.1096/fj.03-1449com","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"16507759","source_url":"https://pubmed.ncbi.nlm.nih.gov/16507759/","study_design":null,"title":"Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease","title_match":true,"year":2006},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-rt-quic-in-the-csf-of-patients-with-alpha-27752516","doi":"10.1002/acn3.338","journal":"Annals of clinical and translational neurology","n_participants":null,"pmid":"27752516","source_url":"https://pubmed.ncbi.nlm.nih.gov/27752516/","study_design":null,"title":"Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies","title_match":true,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/dj-1-and-alpha-synuclein-in-human-cerebrospinal-fluid-as-biomarkers-20157014","doi":"10.1093/brain/awq008","journal":"Brain : a journal of neurology","n_participants":117,"pmid":"20157014","source_url":"https://pubmed.ncbi.nlm.nih.gov/20157014/","study_design":null,"title":"DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease","title_match":true,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/development-of-a-biochemical-diagnosis-of-parkinson-disease-by-27918765","doi":"10.1001/jamaneurol.2016.4547","journal":"JAMA neurology","n_participants":76,"pmid":"27918765","source_url":"https://pubmed.ncbi.nlm.nih.gov/27918765/","study_design":null,"title":"Development of a Biochemical Diagnosis of Parkinson Disease by Detection of \u03b1-Synuclein Misfolded Aggregates in Cerebrospinal Fluid","title_match":true,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/induction-of-synuclein-aggregate-formation-by-csf-exosomes-from-26647156","doi":"10.1093/brain/awv346","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"26647156","source_url":"https://pubmed.ncbi.nlm.nih.gov/26647156/","study_design":"cross-sectional","title":"Induction of \u03b1-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies","title_match":true,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/validity-of-a-brief-computerized-cognitive-screening-test-in-dementia-22689701","doi":"10.1177/0891988712447894","journal":"Journal of geriatric psychiatry and neurology","n_participants":37,"pmid":"22689701","source_url":"https://pubmed.ncbi.nlm.nih.gov/22689701/","study_design":null,"title":"Validity of a brief computerized cognitive screening test in dementia","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/reliability-of-repeated-cognitive-assessment-of-dementia-using-a-21636581","doi":"10.1177/1533317511411907","journal":"American journal of Alzheimer's disease and other dementias","n_participants":23,"pmid":"21636581","source_url":"https://pubmed.ncbi.nlm.nih.gov/21636581/","study_design":null,"title":"Reliability of repeated cognitive assessment of dementia using a brief computerized battery","title_match":false,"year":2011},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/efficacy-and-safety-of-galantamine-in-patients-with-dementia-with-17409748","doi":"10.1159/000101512","journal":"Dementia and geriatric cognitive disorders","n_participants":50,"pmid":"17409748","source_url":"https://pubmed.ncbi.nlm.nih.gov/17409748/","study_design":"open-label trial","title":"Efficacy and safety of galantamine in patients with dementia with Lewy bodies: a 24-week open-label study","title_match":true,"year":2007},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/automated-analysis-of-facial-emotions-in-subjects-with-cognitive-35061824","doi":"10.1371/journal.pone.0262527","journal":"PloS one","n_participants":493,"pmid":"35061824","source_url":"https://pubmed.ncbi.nlm.nih.gov/35061824/","study_design":null,"title":"Automated analysis of facial emotions in subjects with cognitive impairment","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/assessing-change-in-cognitive-function-in-dementia-the-relative-18322407","doi":"10.1159/000113719","journal":"Neuro-degenerative diseases","n_participants":null,"pmid":"18322407","source_url":"https://pubmed.ncbi.nlm.nih.gov/18322407/","study_design":null,"title":"Assessing change in cognitive function in dementia: the relative utilities of the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Cognitive Drug Research system","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/long-term-air-pollution-exposure-is-associated-with-neuroinflammation-18349428","doi":"10.1177/0192623307313011","journal":"Toxicologic pathology","n_participants":12,"pmid":"18349428","source_url":"https://pubmed.ncbi.nlm.nih.gov/18349428/","study_design":null,"title":"Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults","title_match":true,"year":2008},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/chronic-traumatic-encephalopathy-in-a-national-football-league-player-15987548","doi":"10.1227/01.neu.0000163407.92769.ed","journal":"Neurosurgery","n_participants":null,"pmid":"15987548","source_url":"https://pubmed.ncbi.nlm.nih.gov/15987548/","study_design":null,"title":"Chronic traumatic encephalopathy in a National Football League player","title_match":false,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/calcium-and-neurodegeneration-17328689","doi":"10.1111/j.1474-9726.2007.00275.x","journal":"Aging cell","n_participants":null,"pmid":"17328689","source_url":"https://pubmed.ncbi.nlm.nih.gov/17328689/","study_design":null,"title":"Calcium and neurodegeneration","title_match":false,"year":2007},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/investigating-the-genetic-architecture-of-dementia-with-lewy-bodies-a-29263008","doi":"10.1016/s1474-4422(17)30400-3","journal":"The Lancet. Neurology","n_participants":1743,"pmid":"29263008","source_url":"https://pubmed.ncbi.nlm.nih.gov/29263008/","study_design":"meta-analysis","title":"Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study","title_match":true,"year":2018},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/genetic-modifiers-of-risk-and-age-at-onset-in-gba-associated-31755958","doi":"10.1093/brain/awz350","journal":"Brain : a journal of neurology","n_participants":165,"pmid":"31755958","source_url":"https://pubmed.ncbi.nlm.nih.gov/31755958/","study_design":"case-control study","title":"Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-proteinopathy-or-lipidopathy-31909184","doi":"10.1038/s41531-019-0103-7","journal":"NPJ Parkinson's disease","n_participants":null,"pmid":"31909184","source_url":"https://pubmed.ncbi.nlm.nih.gov/31909184/","study_design":null,"title":"Parkinson's disease: proteinopathy or lipidopathy?","title_match":false,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/an-examination-of-a-novel-multipanel-of-csf-biomarkers-in-the-33336877","doi":"10.1002/alz.12204","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":720,"pmid":"33336877","source_url":"https://pubmed.ncbi.nlm.nih.gov/33336877/","study_design":null,"title":"An examination of a novel multipanel of CSF biomarkers in the Alzheimer's disease clinical and pathological continuum","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/fibrils-formed-in-vitro-from-alpha-synuclein-and-two-mutant-forms-10704204","doi":"10.1021/bi991447r","journal":"Biochemistry","n_participants":null,"pmid":"10704204","source_url":"https://pubmed.ncbi.nlm.nih.gov/10704204/","study_design":null,"title":"Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid","title_match":true,"year":2000},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/comparison-of-kindreds-with-parkinsonism-and-alpha-synuclein-genomic-14755720","doi":"10.1002/ana.10846","journal":"Annals of neurology","n_participants":null,"pmid":"14755720","source_url":"https://pubmed.ncbi.nlm.nih.gov/14755720/","study_design":null,"title":"Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications","title_match":true,"year":2004},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mechanisms-of-molecular-mimicry-involving-the-microbiota-in-25589730","doi":"10.3233/jad-142841","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25589730","source_url":"https://pubmed.ncbi.nlm.nih.gov/25589730/","study_design":null,"title":"Mechanisms of molecular mimicry involving the microbiota in neurodegeneration","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-sequesters-dnmt1-from-the-nucleus-a-novel-mechanism-21296890","doi":"10.1074/jbc.c110.212589","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"21296890","source_url":"https://pubmed.ncbi.nlm.nih.gov/21296890/","study_design":null,"title":"Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases","title_match":true,"year":2011},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cd4-t-cells-contribute-to-neurodegeneration-in-lewy-body-dementia-34648304","doi":"10.1126/science.abf7266","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"34648304","source_url":"https://pubmed.ncbi.nlm.nih.gov/34648304/","study_design":null,"title":"CD4 + T cells contribute to neurodegeneration in Lewy body dementia","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/tau-pet-imaging-in-neurodegenerative-tauopathies-still-a-challenge-30635637","doi":"10.1038/s41380-018-0342-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"30635637","source_url":"https://pubmed.ncbi.nlm.nih.gov/30635637/","study_design":null,"title":"Tau PET imaging in neurodegenerative tauopathies-still a challenge","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/av-1451-tau-and-amyloid-positron-emission-tomography-imaging-in-27863444","doi":"10.1002/ana.24825","journal":"Annals of neurology","n_participants":19,"pmid":"27863444","source_url":"https://pubmed.ncbi.nlm.nih.gov/27863444/","study_design":null,"title":"AV-1451 tau and \u03b2-amyloid positron emission tomography imaging in dementia with Lewy bodies","title_match":true,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-synucleins-11806835","doi":"10.1186/gb-2001-3-1-reviews3002","journal":"Genome biology","n_participants":null,"pmid":"11806835","source_url":"https://pubmed.ncbi.nlm.nih.gov/11806835/","study_design":null,"title":"The synucleins","title_match":false,"year":2002},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/gba-gaucher-disease-and-parkinson-s-disease-from-genetic-to-clinic-to-31010158","doi":"10.3390/cells8040364","journal":"Cells","n_participants":null,"pmid":"31010158","source_url":"https://pubmed.ncbi.nlm.nih.gov/31010158/","study_design":null,"title":"GBA , Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/idiopathic-rapid-eye-movement-sleep-behaviour-disorder-diagnosis-26971662","doi":"10.1016/s1474-4422(16)00057-0","journal":"The Lancet. Neurology","n_participants":null,"pmid":"26971662","source_url":"https://pubmed.ncbi.nlm.nih.gov/26971662/","study_design":"longitudinal study","title":"Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/lewy-body-dementias-dementia-with-lewy-bodies-and-parkinson-disease-27042903","doi":"10.1212/con.0000000000000309","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"27042903","source_url":"https://pubmed.ncbi.nlm.nih.gov/27042903/","study_design":null,"title":"Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia","title_match":true,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuropathology-of-non-motor-features-of-parkinson-disease-20082965","doi":"10.1016/s1353-8020(09)70769-2","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"20082965","source_url":"https://pubmed.ncbi.nlm.nih.gov/20082965/","study_design":null,"title":"Neuropathology of non-motor features of Parkinson disease","title_match":false,"year":2009},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/prodromal-autonomic-symptoms-and-signs-in-parkinson-s-disease-and-23554107","doi":"10.1002/mds.25445","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":91,"pmid":"23554107","source_url":"https://pubmed.ncbi.nlm.nih.gov/23554107/","study_design":"prospective cohort","title":"Prodromal autonomic symptoms and signs in Parkinson's disease and dementia with Lewy bodies","title_match":true,"year":2013},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-coeruleus-subcoeruleus-complex-in-idiopathic-rapid-eye-movement-26920675","doi":"10.1093/brain/aww006","journal":"Brain : a journal of neurology","n_participants":21,"pmid":"26920675","source_url":"https://pubmed.ncbi.nlm.nih.gov/26920675/","study_design":null,"title":"The coeruleus/subcoeruleus complex in idiopathic rapid eye movement sleep behaviour disorder","title_match":false,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/amyloid-load-in-parkinson-s-disease-dementia-and-lewy-body-dementia-18653550","doi":"10.1136/jnnp.2007.127878","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":13,"pmid":"18653550","source_url":"https://pubmed.ncbi.nlm.nih.gov/18653550/","study_design":null,"title":"Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography","title_match":true,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-neuroprotective-effects-of-glucagon-like-peptide-1-in-alzheimer-s-36117625","doi":"10.3389/fnins.2022.970925","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"36117625","source_url":"https://pubmed.ncbi.nlm.nih.gov/36117625/","study_design":null,"title":"The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/role-of-plant-derived-alkaloids-and-their-mechanism-in-29559851","doi":"10.7150/ijbs.23247","journal":"International journal of biological sciences","n_participants":null,"pmid":"29559851","source_url":"https://pubmed.ncbi.nlm.nih.gov/29559851/","study_design":null,"title":"Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/epigallocatechin-3-gallate-egcg-maintains-kappa-casein-in-its-pre-19616561","doi":"10.1016/j.jmb.2009.07.031","journal":"Journal of molecular biology","n_participants":null,"pmid":"19616561","source_url":"https://pubmed.ncbi.nlm.nih.gov/19616561/","study_design":null,"title":"(-)-epigallocatechin-3-gallate (EGCG) maintains kappa-casein in its pre-fibrillar state without redirecting its aggregation pathway","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/pet-imaging-of-brain-amyloid-in-dementia-a-review-21905095","doi":"10.1002/gps.2640","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"21905095","source_url":"https://pubmed.ncbi.nlm.nih.gov/21905095/","study_design":null,"title":"PET imaging of brain amyloid in dementia: a review","title_match":false,"year":2011},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/use-of-artificial-intelligence-in-imaging-dementia-39682713","doi":"10.3390/cells13231965","journal":"Cells","n_participants":null,"pmid":"39682713","source_url":"https://pubmed.ncbi.nlm.nih.gov/39682713/","study_design":null,"title":"Use of Artificial Intelligence in Imaging Dementia","title_match":false,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/synucleins-are-developmentally-expressed-and-alpha-synuclein-10777786","doi":"10.1523/jneurosci.20-09-03214.2000","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"10777786","source_url":"https://pubmed.ncbi.nlm.nih.gov/10777786/","study_design":null,"title":"Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons","title_match":true,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neurofibrillary-tangles-of-alzheimer-s-disease-brains-contain-14-3-3-8734909","doi":"10.1016/0304-3940(96)12598-2","journal":"Neuroscience letters","n_participants":null,"pmid":"8734909","source_url":"https://pubmed.ncbi.nlm.nih.gov/8734909/","study_design":null,"title":"Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins","title_match":false,"year":1996},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/nitration-of-tau-protein-is-linked-to-neurodegeneration-in-tauopathies-12937143","doi":"10.1016/s0002-9440(10)63462-1","journal":"The American journal of pathology","n_participants":null,"pmid":"12937143","source_url":"https://pubmed.ncbi.nlm.nih.gov/12937143/","study_design":null,"title":"Nitration of tau protein is linked to neurodegeneration in tauopathies","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/pathological-interface-between-oligomeric-alpha-synuclein-and-tau-in-25676491","doi":"10.1016/j.biopsych.2014.12.019","journal":"Biological psychiatry","n_participants":null,"pmid":"25676491","source_url":"https://pubmed.ncbi.nlm.nih.gov/25676491/","study_design":null,"title":"Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies","title_match":true,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/differential-synuclein-expression-contributes-to-selective-29502200","doi":"10.1007/s00401-018-1829-8","journal":"Acta neuropathologica","n_participants":null,"pmid":"29502200","source_url":"https://pubmed.ncbi.nlm.nih.gov/29502200/","study_design":null,"title":"Differential \u03b1-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity","title_match":true,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/block-of-a1-astrocyte-conversion-by-microglia-is-neuroprotective-in-29892066","doi":"10.1038/s41591-018-0051-5","journal":"Nature medicine","n_participants":null,"pmid":"29892066","source_url":"https://pubmed.ncbi.nlm.nih.gov/29892066/","study_design":null,"title":"Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/incretin-and-insulin-signaling-as-novel-therapeutic-targets-for-36258018","doi":"10.1038/s41380-022-01792-4","journal":"Molecular psychiatry","n_participants":null,"pmid":"36258018","source_url":"https://pubmed.ncbi.nlm.nih.gov/36258018/","study_design":"clinical trial","title":"Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/insulin-resistance-and-exendin-4-treatment-for-multiple-system-atrophy-28334990","doi":"10.1093/brain/awx044","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"28334990","source_url":"https://pubmed.ncbi.nlm.nih.gov/28334990/","study_design":null,"title":"Insulin resistance and exendin-4 treatment for multiple system atrophy","title_match":false,"year":2017},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/gip-has-neuroprotective-effects-in-alzheimer-and-parkinson-s-disease-31705913","doi":"10.1016/j.peptides.2019.170184","journal":"Peptides","n_participants":null,"pmid":"31705913","source_url":"https://pubmed.ncbi.nlm.nih.gov/31705913/","study_design":null,"title":"GIP has neuroprotective effects in Alzheimer and Parkinson's disease models","title_match":false,"year":2020},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/neuroprotective-effects-of-glp-1-receptor-agonists-in-39486172","doi":"10.1016/j.intimp.2024.113537","journal":"International immunopharmacology","n_participants":102935,"pmid":"39486172","source_url":"https://pubmed.ncbi.nlm.nih.gov/39486172/","study_design":"cohort study","title":"Neuroprotective effects of GLP-1 receptor agonists in neurodegenerative Disorders: A Large-Scale Propensity-Matched cohort study","title_match":false,"year":2024},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/memantine-in-patients-with-parkinson-s-disease-dementia-or-dementia-19520613","doi":"10.1016/s1474-4422(09)70146-2","journal":"The Lancet. Neurology","n_participants":72,"pmid":"19520613","source_url":"https://pubmed.ncbi.nlm.nih.gov/19520613/","study_design":null,"title":"Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial","title_match":true,"year":2009},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/practice-parameter-evaluation-and-treatment-of-depression-psychosis-16606910","doi":"10.1212/01.wnl.0000215428.46057.3d","journal":"Neurology","n_participants":null,"pmid":"16606910","source_url":"https://pubmed.ncbi.nlm.nih.gov/16606910/","study_design":null,"title":"Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-contributes-to-gsk-3beta-catalyzed-tau-19369384","doi":"10.1096/fj.08-120410","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"19369384","source_url":"https://pubmed.ncbi.nlm.nih.gov/19369384/","study_design":null,"title":"Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models","title_match":true,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/statins-reduce-neuronal-alpha-synuclein-aggregation-in-in-vitro-18248604","doi":"10.1111/j.1471-4159.2008.05254.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"18248604","source_url":"https://pubmed.ncbi.nlm.nih.gov/18248604/","study_design":null,"title":"Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease","title_match":true,"year":2008},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/ampk-sirt1-pgc-1-signaling-pathway-molecular-mechanisms-and-targeted-41268687","doi":"10.1111/cns.70657","journal":"CNS neuroscience & therapeutics","n_participants":null,"pmid":"41268687","source_url":"https://pubmed.ncbi.nlm.nih.gov/41268687/","study_design":null,"title":"AMPK/SIRT1/PGC-1\u03b1 Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuropathological-diagnostic-criteria-for-creutzfeldt-jakob-disease-8974629","doi":"10.1111/j.1750-3639.1995.tb00625.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"8974629","source_url":"https://pubmed.ncbi.nlm.nih.gov/8974629/","study_design":null,"title":"Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases)","title_match":false,"year":1995},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/essential-tremor-neurodegenerative-or-nondegenerative-disease-towards-19750493","doi":"10.1002/mds.22755","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"19750493","source_url":"https://pubmed.ncbi.nlm.nih.gov/19750493/","study_design":null,"title":"Essential tremor--neurodegenerative or nondegenerative disease towards a working definition of ET","title_match":false,"year":2009},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/hearing-and-dementia-from-ears-to-brain-33351095","doi":"10.1093/brain/awaa429","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"33351095","source_url":"https://pubmed.ncbi.nlm.nih.gov/33351095/","study_design":null,"title":"Hearing and dementia: from ears to brain","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/description-of-parkinson-s-disease-as-a-clinical-syndrome-12846969","doi":"10.1111/j.1749-6632.2003.tb07458.x","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"12846969","source_url":"https://pubmed.ncbi.nlm.nih.gov/12846969/","study_design":null,"title":"Description of Parkinson's disease as a clinical syndrome","title_match":false,"year":2003},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/environmental-pollutants-as-risk-factors-for-neurodegenerative-25914621","doi":"10.3389/fncel.2015.00124","journal":"Frontiers in cellular neuroscience","n_participants":null,"pmid":"25914621","source_url":"https://pubmed.ncbi.nlm.nih.gov/25914621/","study_design":null,"title":"Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases","title_match":false,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/effects-of-air-pollution-on-the-nervous-system-and-its-possible-role-32165138","doi":"10.1016/j.pharmthera.2020.107523","journal":"Pharmacology & therapeutics","n_participants":null,"pmid":"32165138","source_url":"https://pubmed.ncbi.nlm.nih.gov/32165138/","study_design":null,"title":"Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/pesticides-exposure-as-etiological-factors-of-parkinson-s-disease-and-24503016","doi":"10.1016/j.toxlet.2014.01.039","journal":"Toxicology letters","n_participants":null,"pmid":"24503016","source_url":"https://pubmed.ncbi.nlm.nih.gov/24503016/","study_design":null,"title":"Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach","title_match":false,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/urban-air-pollution-influences-on-olfactory-function-and-pathology-in-19297138","doi":"10.1016/j.etp.2009.02.117","journal":"Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie","n_participants":null,"pmid":"19297138","source_url":"https://pubmed.ncbi.nlm.nih.gov/19297138/","study_design":null,"title":"Urban air pollution: influences on olfactory function and pathology in exposed children and young adults","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/synergistic-effects-of-pesticides-and-metals-on-the-fibrillation-of-12428725","doi":"10.1016/s0161-813x(02)00067-0","journal":"Neurotoxicology","n_participants":null,"pmid":"12428725","source_url":"https://pubmed.ncbi.nlm.nih.gov/12428725/","study_design":null,"title":"Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease","title_match":true,"year":2002},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuronal-death-and-survival-under-oxidative-stress-in-alzheimer-and-18220780","doi":"10.2174/187152707783399201","journal":"CNS & neurological disorders drug targets","n_participants":null,"pmid":"18220780","source_url":"https://pubmed.ncbi.nlm.nih.gov/18220780/","study_design":null,"title":"Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases","title_match":false,"year":2007},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-and-alpha-synuclein-pathology-in-the-olfactory-29935448","doi":"10.1016/j.envres.2018.06.027","journal":"Environmental research","n_participants":null,"pmid":"29935448","source_url":"https://pubmed.ncbi.nlm.nih.gov/29935448/","study_design":null,"title":"Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults \u2264 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology","title_match":true,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/early-alzheimer-s-and-parkinson-s-disease-pathology-in-urban-children-23509683","doi":"10.1155/2013/161687","journal":"BioMed research international","n_participants":null,"pmid":"23509683","source_url":"https://pubmed.ncbi.nlm.nih.gov/23509683/","study_design":null,"title":"Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-in-highly-exposed-pm2-5-urbanites-the-27567860","doi":"10.3233/jad-160472","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"27567860","source_url":"https://pubmed.ncbi.nlm.nih.gov/27567860/","study_design":null,"title":"Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/differential-roles-of-m1-and-m2-microglia-in-neurodegenerative-25598354","doi":"10.1007/s12035-014-9070-5","journal":"Molecular neurobiology","n_participants":null,"pmid":"25598354","source_url":"https://pubmed.ncbi.nlm.nih.gov/25598354/","study_design":null,"title":"Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/direct-transfer-of-alpha-synuclein-from-neuron-to-astroglia-causes-20071342","doi":"10.1074/jbc.m109.081125","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"20071342","source_url":"https://pubmed.ncbi.nlm.nih.gov/20071342/","study_design":null,"title":"Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies","title_match":true,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/preliminary-ninds-neuropathologic-criteria-for-steele-richardson-7969952","doi":"10.1212/wnl.44.11.2015","journal":"Neurology","n_participants":null,"pmid":"7969952","source_url":"https://pubmed.ncbi.nlm.nih.gov/7969952/","study_design":null,"title":"Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy)","title_match":false,"year":1994},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-endotoxin-hypothesis-of-neurodegeneration-31519175","doi":"10.1186/s12974-019-1564-7","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"31519175","source_url":"https://pubmed.ncbi.nlm.nih.gov/31519175/","study_design":null,"title":"The endotoxin hypothesis of neurodegeneration","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-from-the-gut-29360467","doi":"10.1016/j.brainres.2018.01.010","journal":"Brain research","n_participants":null,"pmid":"29360467","source_url":"https://pubmed.ncbi.nlm.nih.gov/29360467/","study_design":null,"title":"Parkinson's disease from the gut","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/synuclein-strains-cause-distinct-synucleinopathies-after-local-and-26061766","doi":"10.1038/nature14547","journal":"Nature","n_participants":null,"pmid":"26061766","source_url":"https://pubmed.ncbi.nlm.nih.gov/26061766/","study_design":null,"title":"\u03b1-Synuclein strains cause distinct synucleinopathies after local and systemic administration","title_match":true,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-is-phosphorylated-in-synucleinopathy-lesions-11813001","doi":"10.1038/ncb748","journal":"Nature cell biology","n_participants":null,"pmid":"11813001","source_url":"https://pubmed.ncbi.nlm.nih.gov/11813001/","study_design":null,"title":"alpha-Synuclein is phosphorylated in synucleinopathy lesions","title_match":true,"year":2002},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/atomic-structures-of-amyloid-cross-beta-spines-reveal-varied-steric-17468747","doi":"10.1038/nature05695","journal":"Nature","n_participants":null,"pmid":"17468747","source_url":"https://pubmed.ncbi.nlm.nih.gov/17468747/","study_design":null,"title":"Atomic structures of amyloid cross-beta spines reveal varied steric zippers","title_match":false,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/aggregation-of-alpha-synuclein-in-lewy-bodies-of-sporadic-parkinson-s-9546347","doi":null,"journal":"The American journal of pathology","n_participants":null,"pmid":"9546347","source_url":"https://pubmed.ncbi.nlm.nih.gov/9546347/","study_design":null,"title":"Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies","title_match":true,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/stabilization-of-alpha-synuclein-secondary-structure-upon-binding-to-9545270","doi":"10.1074/jbc.273.16.9443","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"9545270","source_url":"https://pubmed.ncbi.nlm.nih.gov/9545270/","study_design":null,"title":"Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes","title_match":true,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/egcg-redirects-amyloidogenic-polypeptides-into-unstructured-off-18511942","doi":"10.1038/nsmb.1437","journal":"Nature structural & molecular biology","n_participants":null,"pmid":"18511942","source_url":"https://pubmed.ncbi.nlm.nih.gov/18511942/","study_design":null,"title":"EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers","title_match":false,"year":2008},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disease-amyloid-pores-from-pathogenic-mutations-12124613","doi":"10.1038/418291a","journal":"Nature","n_participants":null,"pmid":"12124613","source_url":"https://pubmed.ncbi.nlm.nih.gov/12124613/","study_design":null,"title":"Neurodegenerative disease: amyloid pores from pathogenic mutations","title_match":false,"year":2002},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/intracerebral-inoculation-of-pathological-synuclein-initiates-a-22508839","doi":"10.1084/jem.20112457","journal":"The Journal of experimental medicine","n_participants":null,"pmid":"22508839","source_url":"https://pubmed.ncbi.nlm.nih.gov/22508839/","study_design":null,"title":"Intracerebral inoculation of pathological \u03b1-synuclein initiates a rapidly progressive neurodegenerative \u03b1-synucleinopathy in mice","title_match":true,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/100-years-of-lewy-pathology-23183883","doi":"10.1038/nrneurol.2012.242","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"23183883","source_url":"https://pubmed.ncbi.nlm.nih.gov/23183883/","study_design":null,"title":"100 years of Lewy pathology","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/evidence-for-a-partially-folded-intermediate-in-alpha-synuclein-11152691","doi":"10.1074/jbc.m010907200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"11152691","source_url":"https://pubmed.ncbi.nlm.nih.gov/11152691/","study_design":null,"title":"Evidence for a partially folded intermediate in alpha-synuclein fibril formation","title_match":true,"year":2001},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/egcg-remodels-mature-alpha-synuclein-and-amyloid-beta-fibrils-and-20385841","doi":"10.1073/pnas.0910723107","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"20385841","source_url":"https://pubmed.ncbi.nlm.nih.gov/20385841/","study_design":null,"title":"EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity","title_match":true,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/identification-of-two-distinct-synucleins-from-human-brain-8194594","doi":"10.1016/0014-5793(94)00395-5","journal":"FEBS letters","n_participants":null,"pmid":"8194594","source_url":"https://pubmed.ncbi.nlm.nih.gov/8194594/","study_design":null,"title":"Identification of two distinct synucleins from human brain","title_match":false,"year":1994},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurodegeneration-alzheimer-s-and-parkinson-s-diseases-the-prion-26250687","doi":"10.1126/science.1255555","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"26250687","source_url":"https://pubmed.ncbi.nlm.nih.gov/26250687/","study_design":null,"title":"NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A\u03b2, tau, and \u03b1-synuclein","title_match":true,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/structural-and-functional-characterization-of-two-alpha-synuclein-24108358","doi":"10.1038/ncomms3575","journal":"Nature communications","n_participants":null,"pmid":"24108358","source_url":"https://pubmed.ncbi.nlm.nih.gov/24108358/","study_design":null,"title":"Structural and functional characterization of two alpha-synuclein strains","title_match":true,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-ion-channels-a-common-structural-link-for-protein-misfolding-16020533","doi":"10.1073/pnas.0502066102","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"16020533","source_url":"https://pubmed.ncbi.nlm.nih.gov/16020533/","study_design":null,"title":"Amyloid ion channels: a common structural link for protein-misfolding disease","title_match":false,"year":2005},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/exosomal-cell-to-cell-transmission-of-alpha-synuclein-oligomers-22920859","doi":"10.1186/1750-1326-7-42","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"22920859","source_url":"https://pubmed.ncbi.nlm.nih.gov/22920859/","study_design":null,"title":"Exosomal cell-to-cell transmission of alpha synuclein oligomers","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/structures-of-synuclein-filaments-from-multiple-system-atrophy-32461689","doi":"10.1038/s41586-020-2317-6","journal":"Nature","n_participants":null,"pmid":"32461689","source_url":"https://pubmed.ncbi.nlm.nih.gov/32461689/","study_design":null,"title":"Structures of \u03b1-synuclein filaments from multiple system atrophy","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/distinct-synuclein-strains-differentially-promote-tau-inclusions-in-23827677","doi":"10.1016/j.cell.2013.05.057","journal":"Cell","n_participants":null,"pmid":"23827677","source_url":"https://pubmed.ncbi.nlm.nih.gov/23827677/","study_design":null,"title":"Distinct \u03b1-synuclein strains differentially promote tau inclusions in neurons","title_match":true,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/fiber-diffraction-of-synthetic-alpha-synuclein-filaments-shows-10781096","doi":"10.1073/pnas.97.9.4897","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10781096","source_url":"https://pubmed.ncbi.nlm.nih.gov/10781096/","study_design":null,"title":"Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation","title_match":true,"year":2000},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neuroinflammation-as-a-common-feature-of-neurodegenerative-disorders-31572186","doi":"10.3389/fphar.2019.01008","journal":"Frontiers in pharmacology","n_participants":null,"pmid":"31572186","source_url":"https://pubmed.ncbi.nlm.nih.gov/31572186/","study_design":null,"title":"Neuroinflammation as a Common Feature of Neurodegenerative Disorders","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-promotes-mitochondrial-deficit-and-oxidative-stress-10934145","doi":"10.1016/s0002-9440(10)64553-1","journal":"The American journal of pathology","n_participants":null,"pmid":"10934145","source_url":"https://pubmed.ncbi.nlm.nih.gov/10934145/","study_design":null,"title":"alpha-synuclein promotes mitochondrial deficit and oxidative stress","title_match":true,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/diagnostic-criteria-for-psychosis-in-parkinson-s-disease-report-of-an-17266092","doi":"10.1002/mds.21382","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"17266092","source_url":"https://pubmed.ncbi.nlm.nih.gov/17266092/","study_design":null,"title":"Diagnostic criteria for psychosis in Parkinson's disease: report of an NINDS, NIMH work group","title_match":false,"year":2007},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/neuropathological-correlates-of-dementia-in-over-80-year-old-brain-19661624","doi":"10.3233/jad-2009-1182","journal":"Journal of Alzheimer's disease : JAD","n_participants":213,"pmid":"19661624","source_url":"https://pubmed.ncbi.nlm.nih.gov/19661624/","study_design":"longitudinal study","title":"Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study","title_match":false,"year":2009},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-structure-and-parkinson-s-disease-lessons-and-31331359","doi":"10.1186/s13024-019-0329-1","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31331359","source_url":"https://pubmed.ncbi.nlm.nih.gov/31331359/","study_design":null,"title":"Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles","title_match":true,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/recommendations-to-standardize-preanalytical-confounding-factors-in-22917144","doi":"10.2217/bmm.12.46","journal":"Biomarkers in medicine","n_participants":null,"pmid":"22917144","source_url":"https://pubmed.ncbi.nlm.nih.gov/22917144/","study_design":null,"title":"Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/diagnostic-criteria-for-neuropathologic-assessment-of-alzheimer-s-9330992","doi":"10.1016/s0197-4580(97)00062-6","journal":"Neurobiology of aging","n_participants":null,"pmid":"9330992","source_url":"https://pubmed.ncbi.nlm.nih.gov/9330992/","study_design":null,"title":"Diagnostic criteria for neuropathologic assessment of Alzheimer's disease","title_match":false,"year":1997},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/deep-learning-based-brain-age-prediction-in-normal-aging-and-dementia-37118071","doi":"10.1038/s43587-022-00219-7","journal":"Nature aging","n_participants":null,"pmid":"37118071","source_url":"https://pubmed.ncbi.nlm.nih.gov/37118071/","study_design":"longitudinal study","title":"Deep learning-based brain age prediction in normal aging and dementia","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/accuracy-of-the-clinical-diagnosis-of-corticobasal-degeneration-a-9008506","doi":"10.1212/wnl.48.1.119","journal":"Neurology","n_participants":null,"pmid":"9008506","source_url":"https://pubmed.ncbi.nlm.nih.gov/9008506/","study_design":null,"title":"Accuracy of the clinical diagnosis of corticobasal degeneration: a clinicopathologic study","title_match":false,"year":1997},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/poor-gait-performance-and-prediction-of-dementia-results-from-a-meta-26852960","doi":"10.1016/j.jamda.2015.12.092","journal":"Journal of the American Medical Directors Association","n_participants":null,"pmid":"26852960","source_url":"https://pubmed.ncbi.nlm.nih.gov/26852960/","study_design":"systematic review","title":"Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis","title_match":false,"year":2016},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/association-of-autonomic-dysfunction-with-disease-progression-and-28655059","doi":"10.1001/jamaneurol.2017.1125","journal":"JAMA neurology","n_participants":100,"pmid":"28655059","source_url":"https://pubmed.ncbi.nlm.nih.gov/28655059/","study_design":null,"title":"Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/prevalence-and-severity-of-gait-disorders-in-alzheimer-s-and-non-16181166","doi":"10.1111/j.1532-5415.2005.53552.x","journal":"Journal of the American Geriatrics Society","n_participants":40,"pmid":"16181166","source_url":"https://pubmed.ncbi.nlm.nih.gov/16181166/","study_design":"cross-sectional","title":"Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias","title_match":false,"year":2005},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/substantia-nigra-tangles-are-related-to-gait-impairment-in-older-16374822","doi":"10.1002/ana.20723","journal":"Annals of neurology","n_participants":86,"pmid":"16374822","source_url":"https://pubmed.ncbi.nlm.nih.gov/16374822/","study_design":"longitudinal study","title":"Substantia nigra tangles are related to gait impairment in older persons","title_match":false,"year":2006},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/rapid-eye-movement-sleep-behavior-disorder-and-neurodegenerative-25867792","doi":"10.1001/jamaneurol.2014.4563","journal":"JAMA neurology","n_participants":null,"pmid":"25867792","source_url":"https://pubmed.ncbi.nlm.nih.gov/25867792/","study_design":null,"title":"Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-alpha-synucleinopathies-parkinson-s-disease-dementia-with-lewy-11193145","doi":"10.1111/j.1749-6632.2000.tb06900.x","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"11193145","source_url":"https://pubmed.ncbi.nlm.nih.gov/11193145/","study_design":null,"title":"The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy","title_match":true,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuropathology-biochemistry-and-biophysics-of-alpha-synuclein-17623039","doi":"10.1111/j.1471-4159.2007.04764.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"17623039","source_url":"https://pubmed.ncbi.nlm.nih.gov/17623039/","study_design":null,"title":"Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation","title_match":true,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/casein-kinase-1-delta-is-associated-with-pathological-accumulation-of-10924763","doi":"10.1016/s0197-4580(00)00110-x","journal":"Neurobiology of aging","n_participants":null,"pmid":"10924763","source_url":"https://pubmed.ncbi.nlm.nih.gov/10924763/","study_design":null,"title":"Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/microinfarct-pathology-dementia-and-cognitive-systems-21212395","doi":"10.1161/strokeaha.110.595082","journal":"Stroke","n_participants":null,"pmid":"21212395","source_url":"https://pubmed.ncbi.nlm.nih.gov/21212395/","study_design":null,"title":"Microinfarct pathology, dementia, and cognitive systems","title_match":false,"year":2011},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-p-tau217-and-nfl-in-an-unselected-memory-clinic-39583647","doi":"10.1002/dad2.70003","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"39583647","source_url":"https://pubmed.ncbi.nlm.nih.gov/39583647/","study_design":null,"title":"Performance of plasma p-tau217 and NfL in an unselected memory clinic setting","title_match":false,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-detects-amyloid-in-neuronal-synuclein-41963316","doi":"10.1038/s41531-026-01341-8","journal":"NPJ Parkinson's disease","n_participants":253,"pmid":"41963316","source_url":"https://pubmed.ncbi.nlm.nih.gov/41963316/","study_design":null,"title":"Plasma phosphorylated tau 217 detects amyloid-\u03b2 in neuronal synuclein disease","title_match":false,"year":2026},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/association-between-plasma-p-tau217-and-alzheimer-s-copathology-and-41848292","doi":"10.1002/ana.78201","journal":"Annals of neurology","n_participants":46,"pmid":"41848292","source_url":"https://pubmed.ncbi.nlm.nih.gov/41848292/","study_design":"cohort study","title":"Association between Plasma P-tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease","title_match":false,"year":2026},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-and-neuropsychiatric-symptoms-in-dementia-39732510","doi":"10.1002/alz.14434","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":222,"pmid":"39732510","source_url":"https://pubmed.ncbi.nlm.nih.gov/39732510/","study_design":"longitudinal study","title":"Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/biomarker-treatment-effects-in-two-phase-3-trials-of-gantenerumab-39887500","doi":"10.1002/alz.14414","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39887500","source_url":"https://pubmed.ncbi.nlm.nih.gov/39887500/","study_design":"clinical trial","title":"Biomarker treatment effects in two phase 3 trials of gantenerumab","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/serum-p-tau217-is-a-prognostic-indicator-of-cognitive-impairment-in-41312760","doi":"10.1002/ana.78109","journal":"Annals of neurology","n_participants":300,"pmid":"41312760","source_url":"https://pubmed.ncbi.nlm.nih.gov/41312760/","study_design":null,"title":"Serum p-tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-nfl-gfap-and-ptau181-in-patients-with-isolated-rem-sleep-40488440","doi":"10.1093/sleep/zsaf163","journal":"Sleep","n_participants":44,"pmid":"40488440","source_url":"https://pubmed.ncbi.nlm.nih.gov/40488440/","study_design":"cross-sectional","title":"Plasma NfL, GFAP, and pTau181 in patients with isolated REM sleep behavior disorder","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/early-alzheimer-s-disease-screening-approach-using-plasma-biomarkers-37762457","doi":"10.3390/ijms241814151","journal":"International journal of molecular sciences","n_participants":50,"pmid":"37762457","source_url":"https://pubmed.ncbi.nlm.nih.gov/37762457/","study_design":null,"title":"Early Alzheimer's Disease Screening Approach Using Plasma Biomarkers","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/neuropathologic-correlates-of-distinct-plasma-biomarker-profiles-in-40465828","doi":"10.1093/brain/awaf211","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"40465828","source_url":"https://pubmed.ncbi.nlm.nih.gov/40465828/","study_design":null,"title":"Neuropathologic correlates of distinct plasma biomarker profiles in community-living older adults","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-in-memory-clinic-practice-evidence-36462720","doi":"10.1016/j.nbd.2022.105937","journal":"Neurobiology of disease","n_participants":558,"pmid":"36462720","source_url":"https://pubmed.ncbi.nlm.nih.gov/36462720/","study_design":"cross-sectional","title":"Plasma neurofilament light chain in memory clinic practice: Evidence from a real-life study","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-risk-and-plasma-biomarkers-of-dementia-with-lewy-bodies-in-a-40374660","doi":"10.1038/s41531-025-00988-z","journal":"NPJ Parkinson's disease","n_participants":151,"pmid":"40374660","source_url":"https://pubmed.ncbi.nlm.nih.gov/40374660/","study_design":null,"title":"Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/detection-of-cerebrospinal-fluid-neurofilament-light-chain-as-a-34630068","doi":"10.3389/fnagi.2021.717930","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"34630068","source_url":"https://pubmed.ncbi.nlm.nih.gov/34630068/","study_design":null,"title":"Detection of Cerebrospinal Fluid Neurofilament Light Chain as a Marker for Alpha-Synucleinopathies","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-as-a-predictor-of-multiple-system-41359208","doi":"10.1007/s00415-025-13559-2","journal":"Journal of neurology","n_participants":22,"pmid":"41359208","source_url":"https://pubmed.ncbi.nlm.nih.gov/41359208/","study_design":null,"title":"Plasma neurofilament light chain as a predictor of multiple system atrophy in idiopathic REM sleep behavior disorder","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/diagnostic-and-prognostic-value-of-plasma-neurofilament-light-and-33883011","doi":"10.1186/s13195-021-00815-6","journal":"Alzheimer's research & therapy","n_participants":70,"pmid":"33883011","source_url":"https://pubmed.ncbi.nlm.nih.gov/33883011/","study_design":null,"title":"Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-alzheimer-s-disease-in-the-continuum-of-dementia-38329197","doi":"10.1002/alz.13653","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38329197","source_url":"https://pubmed.ncbi.nlm.nih.gov/38329197/","study_design":null,"title":"Plasma biomarkers of Alzheimer's disease in the continuum of dementia with Lewy bodies","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-relationship-between-plasma-biomarkers-and-amyloid-pet-in-35872565","doi":"10.1016/j.parkreldis.2022.07.008","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"35872565","source_url":"https://pubmed.ncbi.nlm.nih.gov/35872565/","study_design":null,"title":"The relationship between plasma biomarkers and amyloid PET in dementia with Lewy bodies","title_match":true,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/a-combination-of-neurofilament-light-glial-fibrillary-acidic-protein-36120776","doi":"10.3233/jad-220318","journal":"Journal of Alzheimer's disease : JAD","n_participants":37,"pmid":"36120776","source_url":"https://pubmed.ncbi.nlm.nih.gov/36120776/","study_design":null,"title":"A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-predicts-cognitive-progression-in-34151807","doi":"10.3233/jad-210342","journal":"Journal of Alzheimer's disease : JAD","n_participants":45,"pmid":"34151807","source_url":"https://pubmed.ncbi.nlm.nih.gov/34151807/","study_design":null,"title":"Plasma Neurofilament Light Chain Predicts Cognitive Progression in Prodromal and Clinical Dementia with Lewy Bodies","title_match":true,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/systematic-assessment-of-10-biomarker-candidates-focusing-on-34363416","doi":"10.1002/mds.28738","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":151,"pmid":"34363416","source_url":"https://pubmed.ncbi.nlm.nih.gov/34363416/","study_design":null,"title":"Systematic Assessment of 10 Biomarker Candidates Focusing on \u03b1-Synuclein-Related Disorders","title_match":true,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-neurodegeneration-in-mild-cognitive-impairment-37489795","doi":"10.1017/s0033291723001952","journal":"Psychological medicine","n_participants":55,"pmid":"37489795","source_url":"https://pubmed.ncbi.nlm.nih.gov/37489795/","study_design":null,"title":"Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies","title_match":true,"year":2023},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/plasma-markers-of-astrocytic-and-axonal-integrity-in-idiopathic-40879604","doi":"10.1002/mds.70016","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":2004,"pmid":"40879604","source_url":"https://pubmed.ncbi.nlm.nih.gov/40879604/","study_design":"cohort study","title":"Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/specific-cerebrospinal-fluid-serpina1-isoform-pattern-in-alzheimer-s-35805926","doi":"10.3390/ijms23136922","journal":"International journal of molecular sciences","n_participants":29,"pmid":"35805926","source_url":"https://pubmed.ncbi.nlm.nih.gov/35805926/","study_design":null,"title":"Specific Cerebrospinal Fluid SerpinA1 Isoform Pattern in Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/exploring-the-effect-of-apoe-4-on-biomarkers-of-neurodegeneration-in-39025198","doi":"10.1016/j.cca.2024.119876","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":194,"pmid":"39025198","source_url":"https://pubmed.ncbi.nlm.nih.gov/39025198/","study_design":null,"title":"Exploring the effect of APOE \u03b54 on biomarkers of neurodegeneration in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-neurodegeneration-in-patients-and-high-risk-39085262","doi":"10.1038/s41531-024-00745-8","journal":"NPJ Parkinson's disease","n_participants":84,"pmid":"39085262","source_url":"https://pubmed.ncbi.nlm.nih.gov/39085262/","study_design":null,"title":"Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease","title_match":true,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-blood-screening-test-for-dementia-with-lewy-bodies-for-primary-care-40688520","doi":null,"journal":"Journal of Alzheimer's disease & Parkinsonism","n_participants":89,"pmid":"40688520","source_url":"https://pubmed.ncbi.nlm.nih.gov/40688520/","study_design":null,"title":"A Blood Screening Test for Dementia with Lewy Bodies for Primary Care","title_match":true,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-novel-plasma-based-biomarker-of-alzheimer-s-disease-26401710","doi":"10.3233/jad-150183","journal":"Journal of Alzheimer's disease : JAD","n_participants":135,"pmid":"26401710","source_url":"https://pubmed.ncbi.nlm.nih.gov/26401710/","study_design":null,"title":"A Novel Plasma Based Biomarker of Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/fluid-candidate-biomarkers-for-alzheimer-s-disease-a-precision-33187336","doi":"10.3390/jpm10040221","journal":"Journal of personalized medicine","n_participants":null,"pmid":"33187336","source_url":"https://pubmed.ncbi.nlm.nih.gov/33187336/","study_design":null,"title":"Fluid Candidate Biomarkers for Alzheimer's Disease: A Precision Medicine Approach","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neurology-what-s-new-in-2025-41567052","doi":"10.53738/revmed.2026.22.946.48114","journal":"Revue medicale suisse","n_participants":null,"pmid":"41567052","source_url":"https://pubmed.ncbi.nlm.nih.gov/41567052/","study_design":null,"title":"[Neurology : what's new in 2025]","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/advances-in-blood-biomarkers-and-diagnosis-approaches-for-39473150","doi":"10.31083/j.jin2310188","journal":"Journal of integrative neuroscience","n_participants":null,"pmid":"39473150","source_url":"https://pubmed.ncbi.nlm.nih.gov/39473150/","study_design":null,"title":"Advances in Blood Biomarkers and Diagnosis Approaches for Neurodegenerative Dementias and Related Diseases","title_match":false,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/targeted-mass-spectrometry-suggests-beta-synuclein-as-synaptic-blood-32101007","doi":"10.1021/acs.jproteome.9b00824","journal":"Journal of proteome research","n_participants":64,"pmid":"32101007","source_url":"https://pubmed.ncbi.nlm.nih.gov/32101007/","study_design":null,"title":"Targeted Mass Spectrometry Suggests Beta-Synuclein as Synaptic Blood Marker in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/synuclein-as-csf-and-blood-biomarker-of-dementia-with-lewy-bodies-23056991","doi":"10.1155/2012/437025","journal":"International journal of Alzheimer's disease","n_participants":null,"pmid":"23056991","source_url":"https://pubmed.ncbi.nlm.nih.gov/23056991/","study_design":null,"title":"\u03b1-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies","title_match":true,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-dementia-with-lewy-bodies-42261703","doi":"10.1177/13872877261456317","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"42261703","source_url":"https://pubmed.ncbi.nlm.nih.gov/42261703/","study_design":null,"title":"Blood-based biomarkers for dementia with Lewy bodies","title_match":true,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/csf-proteome-profiling-reveals-biomarkers-to-discriminate-dementia-37704597","doi":"10.1038/s41467-023-41122-y","journal":"Nature communications","n_participants":109,"pmid":"37704597","source_url":"https://pubmed.ncbi.nlm.nih.gov/37704597/","study_design":null,"title":"CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer\u00b4s disease","title_match":true,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-and-beta-amyloid-1-42-in-dementia-disorders-11589918","doi":"10.1016/s0047-6374(01)00304-9","journal":"Mechanisms of ageing and development","n_participants":null,"pmid":"11589918","source_url":"https://pubmed.ncbi.nlm.nih.gov/11589918/","study_design":null,"title":"Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders","title_match":false,"year":2001},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-biomarkers-in-neurodegenerative-30814356","doi":"10.3233/jad-181152","journal":"Journal of Alzheimer's disease : JAD","n_participants":213,"pmid":"30814356","source_url":"https://pubmed.ncbi.nlm.nih.gov/30814356/","study_design":null,"title":"Cerebrospinal Fluid and Plasma Biomarkers in Neurodegenerative Diseases","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-synuclein-predicts-neurodegeneration-and-clinical-33228804","doi":"10.1186/s40035-020-00222-1","journal":"Translational neurodegeneration","n_participants":null,"pmid":"33228804","source_url":"https://pubmed.ncbi.nlm.nih.gov/33228804/","study_design":"longitudinal study","title":"Cerebrospinal fluid \u03b1-synuclein predicts neurodegeneration and clinical progression in non-demented elders","title_match":true,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-of-cognitive-decline-in-parkinson-s-28554411","doi":"10.1016/bs.irn.2016.12.001","journal":"International review of neurobiology","n_participants":null,"pmid":"28554411","source_url":"https://pubmed.ncbi.nlm.nih.gov/28554411/","study_design":"longitudinal study","title":"Cerebrospinal Fluid Biomarkers of Cognitive Decline in Parkinson's Disease","title_match":false,"year":2017},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/vgf-peptides-in-cerebrospinal-fluid-of-patients-with-dementia-with-31547145","doi":"10.3390/ijms20194674","journal":"International journal of molecular sciences","n_participants":null,"pmid":"31547145","source_url":"https://pubmed.ncbi.nlm.nih.gov/31547145/","study_design":"longitudinal study","title":"VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies","title_match":true,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-and-synuclein-cerebrospinal-fluid-biomarkers-and-cognition-in-25971633","doi":"10.1016/j.parkreldis.2015.04.027","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"25971633","source_url":"https://pubmed.ncbi.nlm.nih.gov/25971633/","study_design":null,"title":"Amyloid-\u03b2 and \u03b1-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease","title_match":true,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/correlation-between-decreased-csf-synuclein-and-a142-in-parkinson-25212463","doi":"10.1016/j.neurobiolaging.2014.07.043","journal":"Neurobiology of aging","n_participants":null,"pmid":"25212463","source_url":"https://pubmed.ncbi.nlm.nih.gov/25212463/","study_design":null,"title":"Correlation between decreased CSF \u03b1-synuclein and A\u03b2\u2081\u208b\u2084\u2082 in Parkinson disease","title_match":true,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mapping-cerebrospinal-fluid-biomarkers-to-dementia-risk-through-41029146","doi":"10.1097/md.0000000000044658","journal":"Medicine","n_participants":null,"pmid":"41029146","source_url":"https://pubmed.ncbi.nlm.nih.gov/41029146/","study_design":null,"title":"Mapping cerebrospinal fluid biomarkers to dementia risk through Mendelian randomization","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/increased-cerebrospinal-fluid-concentration-of-znt3-is-associated-32925049","doi":"10.3233/jad-200498","journal":"Journal of Alzheimer's disease : JAD","n_participants":24,"pmid":"32925049","source_url":"https://pubmed.ncbi.nlm.nih.gov/32925049/","study_design":null,"title":"Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/increased-csf-synuclein-levels-in-alzheimer-s-disease-correlation-24439167","doi":"10.1016/j.jalz.2013.10.004","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"24439167","source_url":"https://pubmed.ncbi.nlm.nih.gov/24439167/","study_design":null,"title":"Increased CSF \u03b1-synuclein levels in Alzheimer's disease: correlation with tau levels","title_match":true,"year":2014},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-pathology-influences-a1-42-cerebrospinal-fluid-levels-in-23364139","doi":"10.3233/jad-122176","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"23364139","source_url":"https://pubmed.ncbi.nlm.nih.gov/23364139/","study_design":null,"title":"Amyloid pathology influences a\u03b21-42 cerebrospinal fluid levels in dementia with lewy bodies","title_match":true,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/differential-diagnosis-of-dementia-with-high-levels-of-cerebrospinal-26890785","doi":"10.3233/jad-151111","journal":"Journal of Alzheimer's disease : JAD","n_participants":202,"pmid":"26890785","source_url":"https://pubmed.ncbi.nlm.nih.gov/26890785/","study_design":null,"title":"Differential Diagnosis of Dementia with High Levels of Cerebrospinal Fluid Tau Protein","title_match":false,"year":2016},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-nptx2-p-tau-ratio-as-a-biomarker-for-cognitive-42326467","doi":"10.1002/dad2.70391","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":688,"pmid":"42326467","source_url":"https://pubmed.ncbi.nlm.nih.gov/42326467/","study_design":null,"title":"Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/neuropsychological-and-behavioural-correlates-of-csf-biomarkers-in-16434124","doi":"10.1016/j.neuint.2005.11.002","journal":"Neurochemistry international","n_participants":201,"pmid":"16434124","source_url":"https://pubmed.ncbi.nlm.nih.gov/16434124/","study_design":null,"title":"Neuropsychological and behavioural correlates of CSF biomarkers in dementia","title_match":false,"year":2006},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/characteristics-of-drawing-process-differentiate-alzheimer-s-disease-36155515","doi":"10.3233/jad-220546","journal":"Journal of Alzheimer's disease : JAD","n_participants":47,"pmid":"36155515","source_url":"https://pubmed.ncbi.nlm.nih.gov/36155515/","study_design":null,"title":"Characteristics of Drawing Process Differentiate Alzheimer's Disease and Dementia with Lewy Bodies","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/postural-control-characteristics-in-alzheimer-s-disease-dementia-with-38412449","doi":"10.1093/gerona/glae061","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":789,"pmid":"38412449","source_url":"https://pubmed.ncbi.nlm.nih.gov/38412449/","study_design":"cross-sectional","title":"Postural Control Characteristics in Alzheimer's Disease, Dementia With Lewy Bodies, and Vascular Dementia","title_match":true,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-light-reflex-pupillometry-in-alzheimer-s-39086497","doi":"10.1002/dad2.12628","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":107,"pmid":"39086497","source_url":"https://pubmed.ncbi.nlm.nih.gov/39086497/","study_design":"cross-sectional","title":"Diagnostic performance of light reflex pupillometry in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/postural-sway-characteristics-distinguish-types-of-dementia-39956153","doi":"10.1016/j.jamda.2025.105497","journal":"Journal of the American Medical Directors Association","n_participants":1734,"pmid":"39956153","source_url":"https://pubmed.ncbi.nlm.nih.gov/39956153/","study_design":"cross-sectional","title":"Postural Sway Characteristics Distinguish Types of Dementia","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-regulates-lipid-metabolism-and-synuclein-pathology-34453582","doi":"10.1007/s00401-021-02361-9","journal":"Acta neuropathologica","n_participants":null,"pmid":"34453582","source_url":"https://pubmed.ncbi.nlm.nih.gov/34453582/","study_design":null,"title":"Apolipoprotein E regulates lipid metabolism and \u03b1-synuclein pathology in human iPSC-derived cerebral organoids","title_match":true,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-gene-in-synucleinopathies-a-narrative-review-38339074","doi":"10.3390/ijms25031795","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38339074","source_url":"https://pubmed.ncbi.nlm.nih.gov/38339074/","study_design":"narrative review","title":"Apolipoprotein E Gene in \u03b1-Synucleinopathies: A Narrative Review","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-requires-lipidation-enhancement-to-resolve-cellular-lipid-and-40301465","doi":"10.1038/s41598-025-96531-4","journal":"Scientific reports","n_participants":null,"pmid":"40301465","source_url":"https://pubmed.ncbi.nlm.nih.gov/40301465/","study_design":null,"title":"ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition","title_match":false,"year":2025},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-provides-insights-into-the-genetic-41068259","doi":"10.1038/s41380-025-03295-4","journal":"Molecular psychiatry","n_participants":null,"pmid":"41068259","source_url":"https://pubmed.ncbi.nlm.nih.gov/41068259/","study_design":"meta-analysis","title":"Genome-wide association study provides insights into the genetic basis of Lewy body dementia","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/assessment-of-genetic-risk-for-improved-clinical-neuropathological-32912321","doi":"10.1186/s40478-020-01033-1","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"32912321","source_url":"https://pubmed.ncbi.nlm.nih.gov/32912321/","study_design":null,"title":"Assessment of genetic risk for improved clinical-neuropathological correlations","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/shared-genes-and-pathways-in-dementia-insights-from-genome-wide-41198606","doi":"10.1002/alz.70845","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41198606","source_url":"https://pubmed.ncbi.nlm.nih.gov/41198606/","study_design":null,"title":"Shared genes and pathways in dementia: Insights from genome-wide association studies","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/potential-biomarkers-in-cerebrospinal-fluid-and-plasma-for-dementia-38875042","doi":"10.3233/jad-240260","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"38875042","source_url":"https://pubmed.ncbi.nlm.nih.gov/38875042/","study_design":null,"title":"Potential Biomarkers in Cerebrospinal Fluid and Plasma for Dementia","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/causal-association-between-systemic-lupus-erythematosus-and-the-risk-36569847","doi":"10.3389/fimmu.2022.1063110","journal":"Frontiers in immunology","n_participants":null,"pmid":"36569847","source_url":"https://pubmed.ncbi.nlm.nih.gov/36569847/","study_design":null,"title":"Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study","title_match":false,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/structural-variants-linked-to-alzheimer-s-disease-and-other-common-40038788","doi":"10.1186/s13073-025-01444-6","journal":"Genome medicine","n_participants":1088,"pmid":"40038788","source_url":"https://pubmed.ncbi.nlm.nih.gov/40038788/","study_design":"cohort study","title":"Structural variants linked to Alzheimer's disease and other common age-related clinical and neuropathologic traits","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/role-of-triggering-receptor-expressed-on-myeloid-cells-2-trem2-in-33786894","doi":"10.1111/ejn.15215","journal":"The European journal of neuroscience","n_participants":null,"pmid":"33786894","source_url":"https://pubmed.ncbi.nlm.nih.gov/33786894/","study_design":null,"title":"Role of triggering receptor expressed on myeloid cells 2 (TREM2) in neurodegenerative dementias","title_match":false,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/psen2-thr421met-mutation-in-a-patient-with-early-onset-alzheimer-s-36362122","doi":"10.3390/ijms232113331","journal":"International journal of molecular sciences","n_participants":null,"pmid":"36362122","source_url":"https://pubmed.ncbi.nlm.nih.gov/36362122/","study_design":null,"title":"PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/presenilin-1-psen1-mutations-clinical-phenotypes-beyond-alzheimer-s-37176125","doi":"10.3390/ijms24098417","journal":"International journal of molecular sciences","n_participants":null,"pmid":"37176125","source_url":"https://pubmed.ncbi.nlm.nih.gov/37176125/","study_design":null,"title":"Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/progressive-cognitive-impairment-and-familial-spastic-paraparesis-due-35438347","doi":"10.1007/s00415-022-11125-8","journal":"Journal of neurology","n_participants":null,"pmid":"35438347","source_url":"https://pubmed.ncbi.nlm.nih.gov/35438347/","study_design":null,"title":"Progressive cognitive impairment and familial spastic paraparesis due to PRESENILIN 1 mutation: anatomoclinical characterization","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/single-cell-transcriptomic-and-proteomic-analysis-of-parkinson-s-39475571","doi":"10.1126/scitranslmed.abo1997","journal":"Science translational medicine","n_participants":null,"pmid":"39475571","source_url":"https://pubmed.ncbi.nlm.nih.gov/39475571/","study_design":null,"title":"Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neuronal-identity-defines-synuclein-and-tau-toxicity-36948206","doi":"10.1016/j.neuron.2023.02.033","journal":"Neuron","n_participants":null,"pmid":"36948206","source_url":"https://pubmed.ncbi.nlm.nih.gov/36948206/","study_design":null,"title":"Neuronal identity defines \u03b1-synuclein and tau toxicity","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-human-microglia-atlas-humica-unravels-changes-in-disease-39820004","doi":"10.1038/s41467-025-56124-1","journal":"Nature communications","n_participants":90716,"pmid":"39820004","source_url":"https://pubmed.ncbi.nlm.nih.gov/39820004/","study_design":null,"title":"The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/comparative-mapping-of-single-cell-transcriptomic-landscapes-in-39764045","doi":"10.1101/2024.12.13.628436","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39764045","source_url":"https://pubmed.ncbi.nlm.nih.gov/39764045/","study_design":null,"title":"Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases","title_match":false,"year":2024},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/spatial-multi-omics-workflow-and-analytical-guidelines-for-alzheimer-41332529","doi":"10.1101/2025.11.16.688710","journal":"bioRxiv : the preprint server for biology","n_participants":null,"pmid":"41332529","source_url":"https://pubmed.ncbi.nlm.nih.gov/41332529/","study_design":null,"title":"Spatial Multi-Omics Workflow and Analytical Guidelines for Alzheimer's Neuropathology","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/rna-isoform-diversity-in-human-neurodegenerative-diseases-39658200","doi":"10.1523/eneuro.0296-24.2024","journal":"eNeuro","n_participants":null,"pmid":"39658200","source_url":"https://pubmed.ncbi.nlm.nih.gov/39658200/","study_design":null,"title":"RNA Isoform Diversity in Human Neurodegenerative Diseases","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-role-of-18f-flortaucipir-av-1451-in-the-diagnosis-of-34458044","doi":"10.7759/cureus.16644","journal":"Cureus","n_participants":null,"pmid":"34458044","source_url":"https://pubmed.ncbi.nlm.nih.gov/34458044/","study_design":null,"title":"The Role of 18F-Flortaucipir (AV-1451) in the Diagnosis of Neurodegenerative Disorders","title_match":false,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/longitudinal-tau-positron-emission-tomography-in-dementia-with-lewy-35261094","doi":"10.1002/mds.28973","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":22,"pmid":"35261094","source_url":"https://pubmed.ncbi.nlm.nih.gov/35261094/","study_design":"longitudinal study","title":"Longitudinal Tau Positron Emission Tomography in Dementia with Lewy Bodies","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-18f-flortaucipir-18f-mk-6240-and-18f-pi-38280071","doi":"10.1007/s00401-023-02672-z","journal":"Acta neuropathologica","n_participants":null,"pmid":"38280071","source_url":"https://pubmed.ncbi.nlm.nih.gov/38280071/","study_design":null,"title":"Head-to-head comparison of [18F]-Flortaucipir, [18F]-MK-6240 and [18F]-PI-2620 postmortem binding across the spectrum of neurodegenerative diseases","title_match":false,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/18f-pi-2620-tau-pet-is-associated-with-cognitive-and-motor-impairment-39741783","doi":"10.1093/braincomms/fcae458","journal":"Brain communications","n_participants":29,"pmid":"39741783","source_url":"https://pubmed.ncbi.nlm.nih.gov/39741783/","study_design":null,"title":"18F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease","title_match":true,"year":2025},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/tau-pet-imaging-in-parkinson-s-disease-a-systematic-review-and-meta-37181568","doi":"10.3389/fneur.2023.1145939","journal":"Frontiers in neurology","n_participants":109,"pmid":"37181568","source_url":"https://pubmed.ncbi.nlm.nih.gov/37181568/","study_design":"systematic review","title":"Tau-PET imaging in Parkinson's disease: a systematic review and meta-analysis","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/atypical-alzheimer-s-disease-phenotypes-with-normal-or-borderline-pet-36001141","doi":"10.1007/s00415-022-11330-5","journal":"Journal of neurology","n_participants":null,"pmid":"36001141","source_url":"https://pubmed.ncbi.nlm.nih.gov/36001141/","study_design":null,"title":"Atypical Alzheimer's disease phenotypes with normal or borderline PET biomarker profiles","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/multimodal-in-vivo-and-postmortem-assessments-of-tau-in-lewy-body-33002767","doi":"10.1016/j.neurobiolaging.2020.08.003","journal":"Neurobiology of aging","n_participants":20,"pmid":"33002767","source_url":"https://pubmed.ncbi.nlm.nih.gov/33002767/","study_design":null,"title":"Multimodal in vivo and postmortem assessments of tau in Lewy body disorders","title_match":true,"year":2020},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/quantification-of-18-f-florbetaben-amyloid-pet-imaging-in-a-mixed-36478646","doi":"10.1002/alz.12886","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":157,"pmid":"36478646","source_url":"https://pubmed.ncbi.nlm.nih.gov/36478646/","study_design":"longitudinal study","title":"Quantification of [18 F]florbetaben amyloid-PET imaging in a mixed memory clinic population: The ABIDE project","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-pet-imaging-applications-beyond-alzheimer-s-disease-25741489","doi":"10.1007/s40336-014-0098-3","journal":"Clinical and translational imaging","n_participants":null,"pmid":"25741489","source_url":"https://pubmed.ncbi.nlm.nih.gov/25741489/","study_design":null,"title":"Amyloid PET imaging: applications beyond Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/functional-disconnectivity-during-inter-task-resting-state-in-29723870","doi":"10.1159/000486780","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"29723870","source_url":"https://pubmed.ncbi.nlm.nih.gov/29723870/","study_design":null,"title":"Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies","title_match":true,"year":2018},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/functional-connectivity-in-dementia-with-lewy-bodies-a-within-and-29193464","doi":"10.1002/hbm.23901","journal":"Human brain mapping","n_participants":null,"pmid":"29193464","source_url":"https://pubmed.ncbi.nlm.nih.gov/29193464/","study_design":null,"title":"Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/functional-brain-connectivity-patterns-associated-with-visual-34113787","doi":"10.3233/adr-200288","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"34113787","source_url":"https://pubmed.ncbi.nlm.nih.gov/34113787/","study_design":null,"title":"Functional Brain Connectivity Patterns Associated with Visual Hallucinations in Dementia with Lewy Bodies","title_match":true,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/csf-proteins-and-resting-state-functional-connectivity-in-parkinson-25979701","doi":"10.1212/wnl.0000000000001681","journal":"Neurology","n_participants":43,"pmid":"25979701","source_url":"https://pubmed.ncbi.nlm.nih.gov/25979701/","study_design":null,"title":"CSF proteins and resting-state functional connectivity in Parkinson disease","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/altered-structural-and-functional-connectivity-in-posterior-cortical-38442778","doi":"10.1016/j.neuroimage.2024.120564","journal":"NeuroImage","n_participants":null,"pmid":"38442778","source_url":"https://pubmed.ncbi.nlm.nih.gov/38442778/","study_design":null,"title":"Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/retinal-imaging-biomarkers-of-neurodegenerative-diseases-34751086","doi":"10.1080/08164622.2021.1984179","journal":"Clinical & experimental optometry","n_participants":null,"pmid":"34751086","source_url":"https://pubmed.ncbi.nlm.nih.gov/34751086/","study_design":null,"title":"Retinal imaging biomarkers of neurodegenerative diseases","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/ophthalmic-manifestations-of-dementing-disorders-34494975","doi":"10.1097/icu.0000000000000807","journal":"Current opinion in ophthalmology","n_participants":null,"pmid":"34494975","source_url":"https://pubmed.ncbi.nlm.nih.gov/34494975/","study_design":null,"title":"Ophthalmic manifestations of dementing disorders","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/visual-dysfunction-in-dementia-with-lewy-bodies-38907811","doi":"10.1007/s11910-024-01349-8","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"38907811","source_url":"https://pubmed.ncbi.nlm.nih.gov/38907811/","study_design":null,"title":"Visual dysfunction in dementia with Lewy bodies","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/nasal-tau-immunotherapy-clears-intracellular-tau-pathology-and-38959324","doi":"10.1126/scitranslmed.adj5958","journal":"Science translational medicine","n_participants":null,"pmid":"38959324","source_url":"https://pubmed.ncbi.nlm.nih.gov/38959324/","study_design":null,"title":"Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/anti-alpha-synuclein-and-anti-tau-immunotherapies-can-a-cocktail-38508903","doi":"10.1016/j.parkreldis.2024.106080","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"38508903","source_url":"https://pubmed.ncbi.nlm.nih.gov/38508903/","study_design":null,"title":"Anti-alpha synuclein and anti-tau immunotherapies: Can a cocktail approach work?","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/tau-immunotherapy-and-imaging-24029727","doi":"10.1159/000354491","journal":"Neuro-degenerative diseases","n_participants":null,"pmid":"24029727","source_url":"https://pubmed.ncbi.nlm.nih.gov/24029727/","study_design":null,"title":"Tau immunotherapy and imaging","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/snca-genetic-lowering-reveals-differential-cognitive-function-of-36517890","doi":"10.1186/s40478-022-01480-y","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"36517890","source_url":"https://pubmed.ncbi.nlm.nih.gov/36517890/","study_design":null,"title":"SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-role-of-tau-imaging-in-parkinsonian-disorders-30293094","doi":"10.1007/s11910-018-0898-3","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"30293094","source_url":"https://pubmed.ncbi.nlm.nih.gov/30293094/","study_design":null,"title":"The Role of Tau Imaging in Parkinsonian Disorders","title_match":false,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/clinical-practice-guidelines-for-dementia-recommendations-for-39944527","doi":"10.12779/dnd.2025.24.1.1","journal":"Dementia and neurocognitive disorders","n_participants":null,"pmid":"39944527","source_url":"https://pubmed.ncbi.nlm.nih.gov/39944527/","study_design":null,"title":"Clinical Practice Guidelines for Dementia: Recommendations for Cholinesterase Inhibitors and Memantine","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/cholinesterase-inhibitors-in-dementia-with-lewy-bodies-a-comparative-17265415","doi":"10.1002/gps.1759","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"17265415","source_url":"https://pubmed.ncbi.nlm.nih.gov/17265415/","study_design":"randomized controlled trial","title":"Cholinesterase inhibitors in dementia with Lewy bodies: a comparative analysis","title_match":true,"year":2007},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/patterns-and-predictors-of-cholinesterase-inhibitor-use-in-dementia-40687401","doi":"10.1002/trc2.70136","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"40687401","source_url":"https://pubmed.ncbi.nlm.nih.gov/40687401/","study_design":null,"title":"Patterns and predictors of cholinesterase inhibitor use in dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/pharmacologic-treatments-of-dementia-12171061","doi":"10.1016/s0025-7125(02)00007-x","journal":"The Medical clinics of North America","n_participants":null,"pmid":"12171061","source_url":"https://pubmed.ncbi.nlm.nih.gov/12171061/","study_design":null,"title":"Pharmacologic treatments of dementia","title_match":false,"year":2002},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/rivastigmine-and-donepezil-treatment-in-moderate-to-moderately-severe-16083542","doi":"10.1185/030079905x56565","journal":"Current medical research and opinion","n_participants":495,"pmid":"16083542","source_url":"https://pubmed.ncbi.nlm.nih.gov/16083542/","study_design":null,"title":"Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period","title_match":false,"year":2005},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/systematic-review-of-pharmacological-interventions-for-people-with-35109724","doi":"10.1080/13607863.2022.2032601","journal":"Aging & mental health","n_participants":135,"pmid":"35109724","source_url":"https://pubmed.ncbi.nlm.nih.gov/35109724/","study_design":"meta-analysis","title":"Systematic review of pharmacological interventions for people with Lewy body dementia","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-emerging-drug-targets-and-therapeutics-33899637","doi":"10.1080/13543784.2021.1916913","journal":"Expert opinion on investigational drugs","n_participants":null,"pmid":"33899637","source_url":"https://pubmed.ncbi.nlm.nih.gov/33899637/","study_design":null,"title":"Dementia with Lewy bodies: emerging drug targets and therapeutics","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/ambroxol-as-a-disease-modifying-treatment-to-reduce-the-risk-of-38027469","doi":"10.1136/bmjno-2023-000535","journal":"BMJ neurology open","n_participants":null,"pmid":"38027469","source_url":"https://pubmed.ncbi.nlm.nih.gov/38027469/","study_design":"open-label trial","title":"Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment in GBA-associated Parkinson's disease: a multicentre, randomised, double-blind, placebo-controlled, phase II trial. The AMBITIOUS study protocol","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/neuroimaging-in-dementia-clinical-radiological-correlation-30482502","doi":"10.1016/j.rx.2018.08.004","journal":"Radiologia","n_participants":null,"pmid":"30482502","source_url":"https://pubmed.ncbi.nlm.nih.gov/30482502/","study_design":null,"title":"Neuroimaging in dementia. Clinical-radiological correlation","title_match":false,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/lrrk2-alpha-synuclein-and-tau-partners-in-crime-or-unfortunate-31085616","doi":"10.1042/bst20180466","journal":"Biochemical Society transactions","n_participants":null,"pmid":"31085616","source_url":"https://pubmed.ncbi.nlm.nih.gov/31085616/","study_design":null,"title":"LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?","title_match":true,"year":2019},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/exercise-for-individuals-with-lewy-body-dementia-a-systematic-review-27258533","doi":"10.1371/journal.pone.0156520","journal":"PloS one","n_participants":16,"pmid":"27258533","source_url":"https://pubmed.ncbi.nlm.nih.gov/27258533/","study_design":"randomized controlled trial","title":"Exercise for Individuals with Lewy Body Dementia: A Systematic Review","title_match":true,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/sleep-and-neurodegeneration-42544975","doi":"10.1212/cont.0000000000001734","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"42544975","source_url":"https://pubmed.ncbi.nlm.nih.gov/42544975/","study_design":null,"title":"Sleep and Neurodegeneration","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/sleep-and-cognitive-impairment-in-neurodegenerative-diseases-31317921","doi":"10.17116/jnevro201911904289","journal":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","n_participants":null,"pmid":"31317921","source_url":"https://pubmed.ncbi.nlm.nih.gov/31317921/","study_design":null,"title":"[Sleep and cognitive impairment in neurodegenerative diseases]","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/sleep-and-circadian-rhythms-in-synucleinopathies-perspectives-for-36951649","doi":"10.1111/apha.13966","journal":"Acta physiologica (Oxford, England)","n_participants":null,"pmid":"36951649","source_url":"https://pubmed.ncbi.nlm.nih.gov/36951649/","study_design":null,"title":"Sleep and circadian rhythms in \u03b1-synucleinopathies-Perspectives for disease modification","title_match":true,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/insomnia-and-somnolence-in-idiopathic-rbd-a-prospective-cohort-study-28649609","doi":"10.1038/s41531-017-0011-7","journal":"NPJ Parkinson's disease","n_participants":151,"pmid":"28649609","source_url":"https://pubmed.ncbi.nlm.nih.gov/28649609/","study_design":null,"title":"Insomnia and somnolence in idiopathic RBD: a prospective cohort study","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/relationship-between-hearing-impairment-and-dementia-and-cognitive-39385207","doi":"10.1186/s13195-024-01586-6","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"39385207","source_url":"https://pubmed.ncbi.nlm.nih.gov/39385207/","study_design":null,"title":"Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/visual-impairment-in-aging-and-cognitive-decline-experience-in-a-31213626","doi":"10.1038/s41598-019-45055-9","journal":"Scientific reports","n_participants":660,"pmid":"31213626","source_url":"https://pubmed.ncbi.nlm.nih.gov/31213626/","study_design":null,"title":"Visual impairment in aging and cognitive decline: experience in a Memory Clinic","title_match":false,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/color-vision-impairment-differentiates-alzheimer-dementia-from-29658429","doi":"10.1177/0891988718767579","journal":"Journal of geriatric psychiatry and neurology","n_participants":15,"pmid":"29658429","source_url":"https://pubmed.ncbi.nlm.nih.gov/29658429/","study_design":null,"title":"Color Vision Impairment Differentiates Alzheimer Dementia From Dementia With Lewy Bodies","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neuropathological-findings-of-dementia-associated-with-subjective-31498297","doi":"10.1097/mao.0000000000002381","journal":"Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology","n_participants":null,"pmid":"31498297","source_url":"https://pubmed.ncbi.nlm.nih.gov/31498297/","study_design":null,"title":"Neuropathological Findings of Dementia Associated With Subjective Hearing Loss","title_match":false,"year":2019},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cardiovascular-risk-factors-and-phenoconversion-to-neurodegenerative-35001898","doi":"10.3233/jpd-212984","journal":"Journal of Parkinson's disease","n_participants":null,"pmid":"35001898","source_url":"https://pubmed.ncbi.nlm.nih.gov/35001898/","study_design":"cohort study","title":"Cardiovascular Risk Factors and Phenoconversion to Neurodegenerative Synucleinopathies in Idiopathic REM Sleep Behavior Disorder","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/environmental-exposure-to-phthalates-and-dementia-with-lewy-bodies-32636213","doi":"10.1136/jnnp-2020-322815","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":45,"pmid":"32636213","source_url":"https://pubmed.ncbi.nlm.nih.gov/32636213/","study_design":null,"title":"Environmental exposure to phthalates and dementia with Lewy bodies: contribution of metabolomics","title_match":true,"year":2020},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/exposure-to-air-pollutants-and-lewy-body-and-parkinson-disease-42133313","doi":"10.1001/jamanetworkopen.2026.12601","journal":"JAMA network open","n_participants":3024,"pmid":"42133313","source_url":"https://pubmed.ncbi.nlm.nih.gov/42133313/","study_design":"case-control study","title":"Exposure to Air Pollutants and Lewy Body and Parkinson Disease-Related Dementias","title_match":true,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-and-parkinson-diseases-frontotemporal-lobar-degeneration-38283093","doi":"10.3389/fnhum.2023.1297467","journal":"Frontiers in human neuroscience","n_participants":null,"pmid":"38283093","source_url":"https://pubmed.ncbi.nlm.nih.gov/38283093/","study_design":null,"title":"Alzheimer and Parkinson diseases, frontotemporal lobar degeneration and amyotrophic lateral sclerosis overlapping neuropathology start in the first two decades of life in pollution exposed urbanites and brain ultrafine particulate matter and industrial nanoparticles, including Fe, Ti, Al, V, Ni, Hg, Co, Cu, Zn, Ag, Pt, Ce, La, Pr and W are key players. Metropolitan Mexico City health crisis is in progress","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/association-between-air-pollution-and-cerebrospinal-fluid-alpha-39280698","doi":"10.3389/fnagi.2024.1422772","journal":"Frontiers in aging neuroscience","n_participants":933,"pmid":"39280698","source_url":"https://pubmed.ncbi.nlm.nih.gov/39280698/","study_design":null,"title":"Association between air pollution and cerebrospinal fluid alpha-synuclein in urban elders: the CABLE study","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/inflammasome-activation-in-neurodegenerative-diseases-34846519","doi":"10.1042/ebc20210021","journal":"Essays in biochemistry","n_participants":null,"pmid":"34846519","source_url":"https://pubmed.ncbi.nlm.nih.gov/34846519/","study_design":null,"title":"Inflammasome activation in neurodegenerative diseases","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/soluble-synuclein-antibody-complexes-activate-the-nlrp3-inflammasome-33833060","doi":"10.1073/pnas.2025847118","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"33833060","source_url":"https://pubmed.ncbi.nlm.nih.gov/33833060/","study_design":null,"title":"Soluble \u03b1-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia","title_match":true,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/introduction-to-the-special-issue-the-brain-gut-axis-34652580","doi":"10.1007/s10571-021-01155-7","journal":"Cellular and molecular neurobiology","n_participants":null,"pmid":"34652580","source_url":"https://pubmed.ncbi.nlm.nih.gov/34652580/","study_design":null,"title":"Introduction to the Special Issue \"The Brain-Gut Axis\"","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/microbiome-gut-brain-dysfunction-in-prodromal-and-symptomatic-lewy-36355185","doi":"10.1007/s00415-022-11461-9","journal":"Journal of neurology","n_participants":null,"pmid":"36355185","source_url":"https://pubmed.ncbi.nlm.nih.gov/36355185/","study_design":null,"title":"Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseases","title_match":true,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/distinct-cerebrovascular-pathways-underlying-alzheimer-s-disease-41379352","doi":"10.1007/s00401-025-02970-8","journal":"Acta neuropathologica","n_participants":29,"pmid":"41379352","source_url":"https://pubmed.ncbi.nlm.nih.gov/41379352/","study_design":null,"title":"Distinct cerebrovascular pathways underlying Alzheimer's disease-related neurodegeneration","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-vascular-risk-factors-and-vascular-neuropathology-in-subjects-35128731","doi":"10.1002/gps.5683","journal":"International journal of geriatric psychiatry","n_participants":363,"pmid":"35128731","source_url":"https://pubmed.ncbi.nlm.nih.gov/35128731/","study_design":null,"title":"The vascular risk factors and vascular neuropathology in subjects with autopsy-confirmed dementia with Lewy bodies","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cerebral-amyloid-angiopathy-related-cognitive-impairment-the-search-28993004","doi":"10.1016/j.neurol.2017.09.006","journal":"Revue neurologique","n_participants":null,"pmid":"28993004","source_url":"https://pubmed.ncbi.nlm.nih.gov/28993004/","study_design":null,"title":"Cerebral amyloid angiopathy-related cognitive impairment: The search for a specific neuropsychological pattern","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neuropathology-of-dementia-disorders-35678405","doi":"10.1212/con.0000000000001137","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"35678405","source_url":"https://pubmed.ncbi.nlm.nih.gov/35678405/","study_design":null,"title":"Neuropathology of Dementia Disorders","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gut-induced-alpha-synuclein-and-tau-propagation-initiate-parkinson-s-39241780","doi":"10.1016/j.neuron.2024.08.003","journal":"Neuron","n_participants":null,"pmid":"39241780","source_url":"https://pubmed.ncbi.nlm.nih.gov/39241780/","study_design":null,"title":"Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson's and Alzheimer's disease co-pathology and behavior impairments","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-evolving-therapeutic-landscape-of-dementia-with-lewy-bodies-41240919","doi":"10.1016/s1474-4422(25)00323-0","journal":"The Lancet. Neurology","n_participants":null,"pmid":"41240919","source_url":"https://pubmed.ncbi.nlm.nih.gov/41240919/","study_design":null,"title":"The evolving therapeutic landscape of dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/alpha-synucleinopathies-28987181","doi":"10.1016/b978-0-12-802395-2.00024-9","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"28987181","source_url":"https://pubmed.ncbi.nlm.nih.gov/28987181/","study_design":null,"title":"Alpha-synucleinopathies","title_match":true,"year":2017},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/tdp-43-prions-28108532","doi":"10.1101/cshperspect.a024463","journal":"Cold Spring Harbor perspectives in medicine","n_participants":null,"pmid":"28108532","source_url":"https://pubmed.ncbi.nlm.nih.gov/28108532/","study_design":null,"title":"TDP-43 Prions","title_match":false,"year":2018},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/clinical-and-diagnostic-implications-of-alzheimer-s-disease-38991041","doi":"10.1093/brain/awae203","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"38991041","source_url":"https://pubmed.ncbi.nlm.nih.gov/38991041/","study_design":null,"title":"Clinical and diagnostic implications of Alzheimer's disease copathology in Lewy body disease","title_match":true,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/lewy-body-disorders-28410662","doi":"10.1016/j.ncl.2017.01.004","journal":"Neurologic clinics","n_participants":null,"pmid":"28410662","source_url":"https://pubmed.ncbi.nlm.nih.gov/28410662/","study_design":null,"title":"Lewy Body Disorders","title_match":true,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/primary-tau-pathology-not-copathology-correlates-with-clinical-31999351","doi":"10.1093/jnen/nlz141","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"31999351","source_url":"https://pubmed.ncbi.nlm.nih.gov/31999351/","study_design":null,"title":"Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/neuropathology-22277522","doi":"10.5692/clinicalneurol.51.1168","journal":"Rinsho shinkeigaku = Clinical neurology","n_participants":null,"pmid":"22277522","source_url":"https://pubmed.ncbi.nlm.nih.gov/22277522/","study_design":null,"title":"[Neuropathology]","title_match":false,"year":2011},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/neuroinflammation-is-associated-with-alzheimer-s-disease-co-pathology-38715119","doi":"10.1186/s40478-024-01786-z","journal":"Acta neuropathologica communications","n_participants":35,"pmid":"38715119","source_url":"https://pubmed.ncbi.nlm.nih.gov/38715119/","study_design":null,"title":"Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/late-nc-staging-in-routine-neuropathologic-diagnosis-an-update-36512061","doi":"10.1007/s00401-022-02524-2","journal":"Acta neuropathologica","n_participants":null,"pmid":"36512061","source_url":"https://pubmed.ncbi.nlm.nih.gov/36512061/","study_design":null,"title":"LATE-NC staging in routine neuropathologic diagnosis: an update","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/proteolytic-synuclein-cleavage-in-health-and-disease-34064208","doi":"10.3390/ijms22115450","journal":"International journal of molecular sciences","n_participants":null,"pmid":"34064208","source_url":"https://pubmed.ncbi.nlm.nih.gov/34064208/","study_design":null,"title":"Proteolytic \u03b1-Synuclein Cleavage in Health and Disease","title_match":true,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/disentangling-and-quantifying-the-relative-cognitive-impact-of-38520489","doi":"10.1007/s00401-024-02716-y","journal":"Acta neuropathologica","n_participants":6262,"pmid":"38520489","source_url":"https://pubmed.ncbi.nlm.nih.gov/38520489/","study_design":null,"title":"Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/modeling-synuclein-propagation-with-preformed-fibril-injections-31556259","doi":"10.14802/jmd.19046","journal":"Journal of movement disorders","n_participants":null,"pmid":"31556259","source_url":"https://pubmed.ncbi.nlm.nih.gov/31556259/","study_design":null,"title":"Modeling \u03b1-Synuclein Propagation with Preformed Fibril Injections","title_match":true,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/polygr-containing-aggregates-link-with-pathology-and-clinical-41204969","doi":"10.1007/s00401-025-02954-8","journal":"Acta neuropathologica","n_participants":null,"pmid":"41204969","source_url":"https://pubmed.ncbi.nlm.nih.gov/41204969/","study_design":null,"title":"PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/lrrk2-kinase-mediated-accumulation-of-lysosome-associated-phospho-41128923","doi":"10.1007/s00401-025-02951-x","journal":"Acta neuropathologica","n_participants":null,"pmid":"41128923","source_url":"https://pubmed.ncbi.nlm.nih.gov/41128923/","study_design":null,"title":"LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/limbic-predominant-age-related-tdp-43-encephalopathy-late-clinical-31845964","doi":"10.1093/jnen/nlz126","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"31845964","source_url":"https://pubmed.ncbi.nlm.nih.gov/31845964/","study_design":null,"title":"Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/sympathetic-noradrenergic-before-striatal-dopaminergic-denervation-21796351","doi":"10.1007/s10286-011-0136-4","journal":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","n_participants":null,"pmid":"21796351","source_url":"https://pubmed.ncbi.nlm.nih.gov/21796351/","study_design":null,"title":"Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy","title_match":false,"year":2012},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/dementia-of-the-oldest-old-33293469","doi":"10.11477/mf.1416201692","journal":"Brain and nerve = Shinkei kenkyu no shinpo","n_participants":null,"pmid":"33293469","source_url":"https://pubmed.ncbi.nlm.nih.gov/33293469/","study_design":null,"title":"[Dementia of the Oldest-Old]","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/pink1-deficiency-permits-the-development-of-lewy-body-dementia-with-40990068","doi":"10.1002/alz.70730","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40990068","source_url":"https://pubmed.ncbi.nlm.nih.gov/40990068/","study_design":null,"title":"PINK1 deficiency permits the development of Lewy body dementia with coexisting A\u03b2 pathology","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/in-dementia-with-lewy-bodies-braak-stage-determines-phenotype-not-17646627","doi":"10.1212/01.wnl.0000266626.64913.0f","journal":"Neurology","n_participants":95,"pmid":"17646627","source_url":"https://pubmed.ncbi.nlm.nih.gov/17646627/","study_design":null,"title":"In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution","title_match":true,"year":2007},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/ageing-related-neurodegeneration-and-cognitive-decline-38612875","doi":"10.3390/ijms25074065","journal":"International journal of molecular sciences","n_participants":1630,"pmid":"38612875","source_url":"https://pubmed.ncbi.nlm.nih.gov/38612875/","study_design":null,"title":"Ageing-Related Neurodegeneration and Cognitive Decline","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/tdp-1-tdp-43-potentiates-human-synuclein-hasn-neurodegeneration-in-32531261","doi":"10.1016/j.bbadis.2020.165876","journal":"Biochimica et biophysica acta. Molecular basis of disease","n_participants":null,"pmid":"32531261","source_url":"https://pubmed.ncbi.nlm.nih.gov/32531261/","study_design":null,"title":"TDP-1/TDP-43 potentiates human \u03b1-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans","title_match":true,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/co-infection-with-two-synuclein-strains-reveals-novel-synergistic-41206373","doi":"10.1007/s00401-025-02957-5","journal":"Acta neuropathologica","n_participants":null,"pmid":"41206373","source_url":"https://pubmed.ncbi.nlm.nih.gov/41206373/","study_design":null,"title":"Co-infection with two \u03b1-synuclein strains reveals novel synergistic interactions","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/rethinking-neurodegeneration-through-a-co-proteinopathy-lens-41203507","doi":"10.1016/j.tins.2025.10.006","journal":"Trends in neurosciences","n_participants":null,"pmid":"41203507","source_url":"https://pubmed.ncbi.nlm.nih.gov/41203507/","study_design":null,"title":"Rethinking neurodegeneration through a co-proteinopathy lens","title_match":false,"year":2025},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/misfolded-synuclein-co-occurrence-with-alzheimer-s-disease-40356020","doi":"10.1002/alz.70205","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":420,"pmid":"40356020","source_url":"https://pubmed.ncbi.nlm.nih.gov/40356020/","study_design":"longitudinal study","title":"Misfolded \u03b1-synuclein co-occurrence with Alzheimer's disease proteinopathy","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/multiple-neurodegenerative-pathologies-in-an-alzheimer-s-disease-33682715","doi":"10.3233/jad-201415","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"33682715","source_url":"https://pubmed.ncbi.nlm.nih.gov/33682715/","study_design":null,"title":"Multiple Neurodegenerative Pathologies in an Alzheimer's Disease Patient Treated with Fornical Deep Brain Stimulation","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/neurodegeneration-and-the-ordered-assembly-of-synuclein-29119326","doi":"10.1007/s00441-017-2706-9","journal":"Cell and tissue research","n_participants":null,"pmid":"29119326","source_url":"https://pubmed.ncbi.nlm.nih.gov/29119326/","study_design":null,"title":"Neurodegeneration and the ordered assembly of \u03b1-synuclein","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/diverse-limbic-comorbidities-cause-limbic-and-temporal-atrophy-in-36368094","doi":"10.1016/j.parkreldis.2022.11.001","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"36368094","source_url":"https://pubmed.ncbi.nlm.nih.gov/36368094/","study_design":null,"title":"Diverse limbic comorbidities cause limbic and temporal atrophy in lewy body disease","title_match":true,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/natural-speech-markers-of-alzheimer-s-disease-co-pathology-in-lewy-35985146","doi":"10.1016/j.parkreldis.2022.07.023","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"35985146","source_url":"https://pubmed.ncbi.nlm.nih.gov/35985146/","study_design":null,"title":"Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/synuclein-mediated-neurodegeneration-in-dementia-with-lewy-bodies-the-34798911","doi":"10.1186/s13578-021-00709-y","journal":"Cell & bioscience","n_participants":null,"pmid":"34798911","source_url":"https://pubmed.ncbi.nlm.nih.gov/34798911/","study_design":null,"title":"\u03b1-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox","title_match":true,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/atrophy-signature-for-alpha-synuclein-copathology-in-alzheimer-s-42255968","doi":"10.1002/dad2.70347","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":139,"pmid":"42255968","source_url":"https://pubmed.ncbi.nlm.nih.gov/42255968/","study_design":null,"title":"Atrophy signature for alpha-synuclein copathology in Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-deposition-patterns-in-alzheimer-s-disease-41165827","doi":"10.1007/s00401-025-02952-w","journal":"Acta neuropathologica","n_participants":null,"pmid":"41165827","source_url":"https://pubmed.ncbi.nlm.nih.gov/41165827/","study_design":null,"title":"Alpha-synuclein deposition patterns in Alzheimer's disease: association with cortical amyloid beta and variable tau load","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/limbic-alzheimer-s-co-pathology-in-multiple-system-atrophy-is-40968282","doi":"10.1007/s00401-025-02940-0","journal":"Acta neuropathologica","n_participants":70,"pmid":"40968282","source_url":"https://pubmed.ncbi.nlm.nih.gov/40968282/","study_design":null,"title":"Limbic Alzheimer's co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/csf-alpha-synuclein-aggregates-by-seed-amplification-and-clinical-37102457","doi":"10.1002/alz.13109","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37102457","source_url":"https://pubmed.ncbi.nlm.nih.gov/37102457/","study_design":"longitudinal study","title":"CSF alpha-synuclein aggregates by seed amplification and clinical presentation of AD","title_match":true,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/distinct-characteristics-of-limbic-predominant-age-related-tdp-43-34854996","doi":"10.1007/s00401-021-02383-3","journal":"Acta neuropathologica","n_participants":313,"pmid":"34854996","source_url":"https://pubmed.ncbi.nlm.nih.gov/34854996/","study_design":null,"title":"Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/amygdala-synuclein-pathology-in-the-population-based-vantaa-85-study-28482633","doi":"10.3233/jad-170104","journal":"Journal of Alzheimer's disease : JAD","n_participants":304,"pmid":"28482633","source_url":"https://pubmed.ncbi.nlm.nih.gov/28482633/","study_design":null,"title":"Amygdala \u03b1-Synuclein Pathology in the Population-Based Vantaa 85+ Study","title_match":true,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/patterns-of-tau-and-synuclein-pathology-in-the-visual-system-25737267","doi":"10.3233/jpd-140485","journal":"Journal of Parkinson's disease","n_participants":null,"pmid":"25737267","source_url":"https://pubmed.ncbi.nlm.nih.gov/25737267/","study_design":null,"title":"Patterns of Tau and \u03b1-Synuclein Pathology in the Visual System","title_match":true,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/evaluating-the-updated-late-nc-staging-criteria-using-data-from-nacc-39352226","doi":"10.1002/alz.14262","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1352,"pmid":"39352226","source_url":"https://pubmed.ncbi.nlm.nih.gov/39352226/","study_design":null,"title":"Evaluating the updated LATE-NC staging criteria using data from NACC","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/synuclein-at-the-presynaptic-axon-terminal-as-a-double-edged-sword-35454096","doi":"10.3390/biom12040507","journal":"Biomolecules","n_participants":null,"pmid":"35454096","source_url":"https://pubmed.ncbi.nlm.nih.gov/35454096/","study_design":null,"title":"\u03b1-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/synuclein-pathology-in-post-mortem-retina-and-optic-nerve-is-specific-37640753","doi":"10.1038/s41531-023-00570-5","journal":"NPJ Parkinson's disease","n_participants":99,"pmid":"37640753","source_url":"https://pubmed.ncbi.nlm.nih.gov/37640753/","study_design":null,"title":"\u03b1-Synuclein pathology in post-mortem retina and optic nerve is specific for \u03b1-synucleinopathies","title_match":true,"year":2023},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/limbic-predominant-age-related-tdp-43-encephalopathy-medical-and-35121671","doi":"10.1212/wnl.0000000000200001","journal":"Neurology","n_participants":221,"pmid":"35121671","source_url":"https://pubmed.ncbi.nlm.nih.gov/35121671/","study_design":"cohort study","title":"Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-braak-hypothesis-in-prion-disease-with-a-focus-on-creutzfeldt-32363728","doi":"10.1111/neup.12654","journal":"Neuropathology : official journal of the Japanese Society of Neuropathology","n_participants":null,"pmid":"32363728","source_url":"https://pubmed.ncbi.nlm.nih.gov/32363728/","study_design":null,"title":"The Braak hypothesis in prion disease with a focus on Creutzfeldt-Jakob disease","title_match":false,"year":2020},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/associations-between-misfolded-alpha-synuclein-aggregates-and-39258841","doi":"10.1002/alz.14225","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2315,"pmid":"39258841","source_url":"https://pubmed.ncbi.nlm.nih.gov/39258841/","study_design":"cross-sectional","title":"Associations between misfolded alpha-synuclein aggregates and Alzheimer's disease pathology in vivo","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/synuclein-as-an-emerging-pathophysiological-biomarker-of-alzheimer-s-35443850","doi":"10.1080/14737159.2022.2068952","journal":"Expert review of molecular diagnostics","n_participants":null,"pmid":"35443850","source_url":"https://pubmed.ncbi.nlm.nih.gov/35443850/","study_design":null,"title":"\u03b1-synuclein as an emerging pathophysiological biomarker of Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/disease-modifying-drugs-for-non-alzheimer-dementias-39251226","doi":"10.11477/mf.1416202733","journal":"Brain and nerve = Shinkei kenkyu no shinpo","n_participants":null,"pmid":"39251226","source_url":"https://pubmed.ncbi.nlm.nih.gov/39251226/","study_design":"clinical trial","title":"[Disease-modifying Drugs for non-Alzheimer Dementias]","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/age-related-pathology-in-corticobasal-degeneration-38473986","doi":"10.3390/ijms25052740","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38473986","source_url":"https://pubmed.ncbi.nlm.nih.gov/38473986/","study_design":null,"title":"Age-Related Pathology in Corticobasal Degeneration","title_match":false,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/amygdalar-and-hippocampal-volume-loss-in-limbic-predominant-age-40512809","doi":"10.1093/brain/awaf201","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"40512809","source_url":"https://pubmed.ncbi.nlm.nih.gov/40512809/","study_design":null,"title":"Amygdalar and hippocampal volume loss in limbic-predominant age-related TDP-43 encephalopathy","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-phospho-tau-identifies-alzheimer-s-co-pathology-in-patients-33285015","doi":"10.1002/mds.28370","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":35,"pmid":"33285015","source_url":"https://pubmed.ncbi.nlm.nih.gov/33285015/","study_design":"cross-sectional","title":"Plasma Phospho-Tau Identifies Alzheimer's Co-Pathology in Patients with Lewy Body Disease","title_match":true,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/collusion-of-synuclein-and-a-aggravating-co-morbidities-in-a-novel-34503546","doi":"10.1186/s13024-021-00486-9","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"34503546","source_url":"https://pubmed.ncbi.nlm.nih.gov/34503546/","study_design":null,"title":"Collusion of \u03b1-Synuclein and A\u03b2 aggravating co-morbidities in a novel prion-type mouse model","title_match":true,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/tdp-43-in-amyotrophic-lateral-sclerosis-is-it-a-prion-disease-25846565","doi":"10.1111/ene.12706","journal":"European journal of neurology","n_participants":null,"pmid":"25846565","source_url":"https://pubmed.ncbi.nlm.nih.gov/25846565/","study_design":null,"title":"TDP-43 in amyotrophic lateral sclerosis - is it a prion disease?","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/htra1-prevents-and-reverses-synuclein-aggregation-rendering-it-non-37674720","doi":"10.21203/rs.3.rs-2570571/v1","journal":"Nature communications","n_participants":null,"pmid":"37674720","source_url":"https://pubmed.ncbi.nlm.nih.gov/37674720/","study_design":null,"title":"HtrA1 prevents and reverses \u03b1-synuclein aggregation, rendering it non-toxic and seeding incompetent","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/a-refined-concept-synuclein-dysregulation-disease-29305061","doi":"10.1016/j.neuint.2017.12.011","journal":"Neurochemistry international","n_participants":null,"pmid":"29305061","source_url":"https://pubmed.ncbi.nlm.nih.gov/29305061/","study_design":null,"title":"A refined concept: \u03b1-synuclein dysregulation disease","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/distinct-neurotoxic-tdp-43-fibril-polymorphs-are-generated-by-36116552","doi":"10.1016/j.jbc.2022.102498","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"36116552","source_url":"https://pubmed.ncbi.nlm.nih.gov/36116552/","study_design":null,"title":"Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with \u03b1-Synuclein","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/aggregation-of-disordered-proteins-associated-with-neurodegeneration-36834792","doi":"10.3390/ijms24043380","journal":"International journal of molecular sciences","n_participants":null,"pmid":"36834792","source_url":"https://pubmed.ncbi.nlm.nih.gov/36834792/","study_design":null,"title":"Aggregation of Disordered Proteins Associated with Neurodegeneration","title_match":false,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/putaminal-hypermetabolism-identifies-lewy-body-co-pathology-in-41273227","doi":"10.1002/alz.70920","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41273227","source_url":"https://pubmed.ncbi.nlm.nih.gov/41273227/","study_design":null,"title":"Putaminal hypermetabolism identifies Lewy body co-pathology in Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-csf-synuclein-seed-amplification-assay-positivity-with-39428831","doi":"10.1002/alz.14276","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1637,"pmid":"39428831","source_url":"https://pubmed.ncbi.nlm.nih.gov/39428831/","study_design":"cross-sectional","title":"Association of CSF \u03b1-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/an-autopsy-case-of-corticobasal-syndrome-with-pure-diffuse-lewy-body-34128767","doi":"10.1080/13554794.2021.1921220","journal":"Neurocase","n_participants":null,"pmid":"34128767","source_url":"https://pubmed.ncbi.nlm.nih.gov/34128767/","study_design":null,"title":"An autopsy case of corticobasal syndrome with pure diffuse Lewy Body Disease","title_match":true,"year":2021},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/synuclein-seed-amplification-assay-detects-lewy-body-co-pathology-in-38666355","doi":"10.1002/alz.13818","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":26,"pmid":"38666355","source_url":"https://pubmed.ncbi.nlm.nih.gov/38666355/","study_design":null,"title":"\u03b1-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden","title_match":true,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/inflammation-in-dementia-with-lewy-bodies-35314318","doi":"10.1016/j.nbd.2022.105698","journal":"Neurobiology of disease","n_participants":null,"pmid":"35314318","source_url":"https://pubmed.ncbi.nlm.nih.gov/35314318/","study_design":"longitudinal study","title":"Inflammation in dementia with Lewy bodies","title_match":true,"year":2022},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-co-pathology-in-a-real-world-early-alzheimer-s-41873784","doi":"10.1002/alz.71240","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":108,"pmid":"41873784","source_url":"https://pubmed.ncbi.nlm.nih.gov/41873784/","study_design":"longitudinal study","title":"Alpha-synuclein co-pathology in a real-world early Alzheimer's disease cohort","title_match":true,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/metabolic-connectomics-targeting-brain-pathology-in-dementia-with-27306756","doi":"10.1177/0271678x16654497","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"27306756","source_url":"https://pubmed.ncbi.nlm.nih.gov/27306756/","study_design":null,"title":"Metabolic connectomics targeting brain pathology in dementia with Lewy bodies","title_match":true,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tmem106b-is-a-selective-modulator-of-tdp-43-pathology-in-alzheimer-s-42720122","doi":"10.1002/alz.71713","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2604,"pmid":"42720122","source_url":"https://pubmed.ncbi.nlm.nih.gov/42720122/","study_design":null,"title":"TMEM106B is a selective modulator of TDP-43 pathology in Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/human-wild-type-synuclein-drives-progressive-tau-pathology-in-a-41377958","doi":"10.21203/rs.3.rs-8166445/v1","journal":"Research square","n_participants":null,"pmid":"41377958","source_url":"https://pubmed.ncbi.nlm.nih.gov/41377958/","study_design":null,"title":"Human Wild-Type \u03b1-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of Synucleinopathy","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/mir-101a-3p-impairs-synaptic-plasticity-and-contributes-to-36744345","doi":"10.3233/jpd-225055","journal":"Journal of Parkinson's disease","n_participants":null,"pmid":"36744345","source_url":"https://pubmed.ncbi.nlm.nih.gov/36744345/","study_design":null,"title":"miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cholesterol-imbalance-and-neurotransmission-defects-in-39085348","doi":"10.1038/s12276-024-01273-4","journal":"Experimental & molecular medicine","n_participants":null,"pmid":"39085348","source_url":"https://pubmed.ncbi.nlm.nih.gov/39085348/","study_design":null,"title":"Cholesterol imbalance and neurotransmission defects in neurodegeneration","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/aging-and-alpha-synuclein-affect-synaptic-plasticity-in-the-dentate-19002552","doi":"10.1007/s00702-008-0149-x","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"19002552","source_url":"https://pubmed.ncbi.nlm.nih.gov/19002552/","study_design":null,"title":"Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus","title_match":true,"year":2009},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/synuclein-triggers-cofilin-pathology-and-dendritic-spine-impairment-38615035","doi":"10.1038/s41419-024-06630-9","journal":"Cell death & disease","n_participants":null,"pmid":"38615035","source_url":"https://pubmed.ncbi.nlm.nih.gov/38615035/","study_design":null,"title":"\u03b1-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/tau-oligomers-impair-memory-and-synaptic-plasticity-through-the-39871396","doi":"10.1186/s40478-025-01930-3","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"39871396","source_url":"https://pubmed.ncbi.nlm.nih.gov/39871396/","study_design":null,"title":"Tau oligomers impair memory and synaptic plasticity through the cellular prion protein","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/early-proteasome-downregulation-and-dysfunction-drive-proteostasis-40488453","doi":"10.1093/brain/awaf222","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"40488453","source_url":"https://pubmed.ncbi.nlm.nih.gov/40488453/","study_design":null,"title":"Early proteasome downregulation and dysfunction drive proteostasis failure in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/autophagy-in-dementias-22150925","doi":"10.1111/j.1750-3639.2011.00545.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"22150925","source_url":"https://pubmed.ncbi.nlm.nih.gov/22150925/","study_design":null,"title":"Autophagy in dementias","title_match":false,"year":2012},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/glia-specific-autophagy-dysfunction-in-als-31132469","doi":"10.1016/j.semcdb.2019.05.024","journal":"Seminars in cell & developmental biology","n_participants":null,"pmid":"31132469","source_url":"https://pubmed.ncbi.nlm.nih.gov/31132469/","study_design":null,"title":"Glia-specific autophagy dysfunction in ALS","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/trpmls-and-tpcs-targets-for-lysosomal-storage-and-neurodegenerative-35144097","doi":"10.1016/j.ceca.2022.102553","journal":"Cell calcium","n_participants":null,"pmid":"35144097","source_url":"https://pubmed.ncbi.nlm.nih.gov/35144097/","study_design":null,"title":"TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/protacs-technology-for-treatment-of-alzheimer-s-disease-advances-and-35237768","doi":"10.15212/amm-2021-0001","journal":"Acta materia medica","n_participants":null,"pmid":"35237768","source_url":"https://pubmed.ncbi.nlm.nih.gov/35237768/","study_design":null,"title":"PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/endosomal-lysosomal-dysfunction-in-metabolic-diseases-and-alzheimer-s-32739009","doi":"10.1016/bs.irn.2020.02.012","journal":"International review of neurobiology","n_participants":null,"pmid":"32739009","source_url":"https://pubmed.ncbi.nlm.nih.gov/32739009/","study_design":null,"title":"Endosomal-lysosomal dysfunction in metabolic diseases and Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/protein-misfolding-and-its-dual-role-in-neurodegeneration-and-cancer-41309196","doi":"10.1016/bs.apcsb.2025.10.001","journal":"Advances in protein chemistry and structural biology","n_participants":null,"pmid":"41309196","source_url":"https://pubmed.ncbi.nlm.nih.gov/41309196/","study_design":null,"title":"Protein misfolding and its dual role in neurodegeneration and cancer progression","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/chemical-mediated-targeted-protein-degradation-in-neurodegenerative-34202541","doi":"10.3390/life11070607","journal":"Life (Basel, Switzerland)","n_participants":null,"pmid":"34202541","source_url":"https://pubmed.ncbi.nlm.nih.gov/34202541/","study_design":null,"title":"Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/risk-of-caregiver-burden-in-patients-with-three-types-of-dementia-30729907","doi":"10.1017/s1041610218000662","journal":"International psychogeriatrics","n_participants":null,"pmid":"30729907","source_url":"https://pubmed.ncbi.nlm.nih.gov/30729907/","study_design":null,"title":"Risk of caregiver burden in patients with three types of dementia","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/general-aspects-of-dementia-disorders-36692517","doi":"10.1007/s00108-022-01462-1","journal":"Innere Medizin (Heidelberg, Germany)","n_participants":null,"pmid":"36692517","source_url":"https://pubmed.ncbi.nlm.nih.gov/36692517/","study_design":null,"title":"[General aspects of dementia disorders]","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/palliative-care-in-parkinson-disease-and-related-disorders-36599503","doi":"10.1016/b978-0-12-824535-4.00017-3","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"36599503","source_url":"https://pubmed.ncbi.nlm.nih.gov/36599503/","study_design":null,"title":"Palliative care in Parkinson disease and related disorders","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/end-of-life-experiences-in-individuals-with-dementia-with-lewy-bodies-39208192","doi":"10.1371/journal.pone.0309530","journal":"PloS one","n_participants":50,"pmid":"39208192","source_url":"https://pubmed.ncbi.nlm.nih.gov/39208192/","study_design":null,"title":"End-of-life experiences in individuals with dementia with Lewy bodies and their caregivers: A mixed-methods analysis","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/psychosis-management-in-lewy-body-dementia-a-comprehensive-clinical-33461372","doi":"10.1177/0891988720988916","journal":"Journal of geriatric psychiatry and neurology","n_participants":null,"pmid":"33461372","source_url":"https://pubmed.ncbi.nlm.nih.gov/33461372/","study_design":null,"title":"Psychosis Management in Lewy Body Dementia: A Comprehensive Clinical Approach","title_match":true,"year":2022},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/racial-and-ethnic-differences-in-the-population-attributable-38232335","doi":"10.1212/wnl.0000000000208116","journal":"Neurology","n_participants":91881,"pmid":"38232335","source_url":"https://pubmed.ncbi.nlm.nih.gov/38232335/","study_design":"cohort study","title":"Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/ethnoracial-differences-in-lewy-body-diseases-with-cognitive-32804137","doi":"10.3233/jad-200395","journal":"Journal of Alzheimer's disease : JAD","n_participants":1782,"pmid":"32804137","source_url":"https://pubmed.ncbi.nlm.nih.gov/32804137/","study_design":null,"title":"Ethnoracial Differences in Lewy Body Diseases with Cognitive Impairment","title_match":true,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/epidemiology-and-economic-burden-of-lewy-body-dementia-in-the-united-35442134","doi":"10.1080/03007995.2022.2059978","journal":"Current medical research and opinion","n_participants":null,"pmid":"35442134","source_url":"https://pubmed.ncbi.nlm.nih.gov/35442134/","study_design":null,"title":"Epidemiology and economic burden of Lewy body dementia in the United States","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/direct-medical-costs-of-dementia-with-lewy-bodies-by-disease-32773201","doi":"10.1016/j.jamda.2020.06.006","journal":"Journal of the American Medical Directors Association","n_participants":536,"pmid":"32773201","source_url":"https://pubmed.ncbi.nlm.nih.gov/32773201/","study_design":null,"title":"Direct Medical Costs of Dementia With Lewy Bodies by Disease Complexity","title_match":true,"year":2020},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/synuclein-seed-amplification-status-modifies-the-relationship-between-af4554ea","doi":"10.21203/rs.3.rs-11271891/v1","journal":"Research Square","n_participants":193,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11271891/v1","study_design":"cross-sectional","title":"\u03b1-Synuclein Seed Amplification Status Modifies the Relationship Between Plasma p-tau217, Amyloid and Fibrillar Tau","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-synuclein-seed-amplification-assay-positivity-0d68a0e1","doi":"10.64898/2026.10.23.26366349","journal":"medRxiv","n_participants":248,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.23.26366349","study_design":"longitudinal study","title":"Cerebrospinal fluid \u03b1-synuclein seed amplification assay positivity identifies a prognostically distinct subgroup in amyotrophic lateral sclerosis","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-dopa-decarboxylase-is-a-biomarker-of-dopaminergic-643ae72b","doi":"10.64898/2026.10.13.26364985","journal":"medRxiv","n_participants":891,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.13.26364985","study_design":null,"title":"Cerebrospinal fluid dopa-decarboxylase is a biomarker of dopaminergic dysfunction","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-susceptibility-to-lewy-body-disease-and-the-distribution-of-87ec1c1b","doi":"10.64898/2026.10.21.26366146","journal":"medRxiv","n_participants":1362,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.21.26366146","study_design":"meta-analysis","title":"Genetic susceptibility to Lewy body disease and the distribution of Lewy pathology","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/structured-metabolic-genetic-axes-reveal-distinct-lipid-and-ketone-ca8d722a","doi":"10.21203/rs.3.rs-11247856/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11247856/v1","study_design":null,"title":"Structured Metabolic Genetic Axes Reveal Distinct Lipid and Ketone-Body Programs in Alzheimer\u2019s and Parkinson\u2019s Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/integration-of-cell-specific-gene-expression-and-chromatin-9f5b4c53","doi":"10.64898/2026.09.15.751821","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.15.751821","study_design":"meta-analysis","title":"Integration of cell-specific gene expression and chromatin accessibility facilitates localization of neurodegenerative risk in microglia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe4-attenuates-early-trem2-mediated-microglial-responses-and-ef1dd141","doi":"10.21203/rs.3.rs-10429506/v1","journal":"Research Square","n_participants":129,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10429506/v1","study_design":"longitudinal study","title":"APOE\u03b54 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodies","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-somnogenesis-system-2c68c82f","doi":"10.14293/pr2199.004616.v1","journal":"ScienceOpen Preprints","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.14293/pr2199.004616.v1","study_design":null,"title":"The Somnogenesis System","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disorders-stereotyped-relationships-between-b01fe529","doi":"10.21203/rs.3.rs-11320531/v1","journal":"Research Square","n_participants":1117,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11320531/v1","study_design":null,"title":"Neurodegenerative disorders: Stereotyped relationships between pathological metabolic topographies and the healthy default mode network","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-somnogenesis-system-a-proposed-biological-system-for-psychiatry-0a5d5bf8","doi":"10.20944/preprints202610.0452.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202610.0452.v1","study_design":null,"title":"The Somnogenesis System: A Proposed Biological System for Psychiatry","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/thalamocortical-correlates-of-sleep-spindle-and-slow-oscillation-939eae22","doi":"10.21203/rs.3.rs-10904079/v1","journal":"Research Square","n_participants":109,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10904079/v1","study_design":null,"title":"Thalamocortical correlates of sleep spindle and slow oscillation dysfunction in Lewy body disorders","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cryo-et-and-sub-volume-analysis-of-fibrillar-pathology-in-the-b5f4b141","doi":"10.64898/2026.09.04.749518","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.04.749518","study_design":null,"title":"Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human Brain","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-biophysical-framework-for-neurodegeneration-prioritizing-protein-7b94959b","doi":"10.20944/preprints202512.2722.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202512.2722.v1","study_design":null,"title":"A Biophysical Framework for Neurodegeneration: Prioritizing Protein Homeostasis Over Aggregate Toxicity","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/glucagon-like-peptide-1-receptor-agonists-and-risk-of-parkinsonian-0839901b","doi":"10.64898/2025.11.24.25340763","journal":"medRxiv","n_participants":11683,"pmid":null,"source_url":"https://doi.org/10.64898/2025.11.24.25340763","study_design":"cohort study","title":"Glucagon-Like Peptide-1 Receptor Agonists and Risk of Parkinsonian Disorders in Patients with Obesity","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/pre-dementia-clinical-trajectories-associated-with-neuronal-synuclein-434cc4bc","doi":"10.21203/rs.3.rs-10788306/v1","journal":"Research Square","n_participants":1543,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10788306/v1","study_design":"longitudinal study","title":"Pre-dementia clinical trajectories associated with neuronal \u03b1-synuclein neuropathologic change: a retrospective cohort study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/high-frequency-oscillations-arise-through-distinct-mechanisms-in-370e6321","doi":"10.21203/rs.3.rs-10385398/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10385398/v1","study_design":null,"title":"High-frequency oscillations arise through distinct mechanisms in models of \u03b1- synucleinopathy and channelopathy-induced epilepsy","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/neurodegeneration-inducing-macromolecules-exit-the-brain-via-211812a0","doi":"10.64898/2026.09.21.752863","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.21.752863","study_design":null,"title":"Neurodegeneration-inducing macromolecules exit the brain via nanovascular conduits formed by reticular fibroblasts","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/inflammatory-biomarker-candidates-in-dementia-with-lewy-bodies-532af7a3","doi":"10.21203/rs.3.rs-11368506/v1","journal":"Research Square","n_participants":20,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11368506/v1","study_design":null,"title":"Inflammatory biomarker candidates in dementia with Lewy bodies: diagnostic classification, clinical associations, and survival","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/tmem106b-c-terminal-fragment-aggregation-exacerbates-synuclein-and-da5e172b","doi":"10.64898/2026.10.29.762961","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.29.762961","study_design":null,"title":"TMEM106B C-Terminal fragment aggregation exacerbates \u03b1-synuclein and TDP-43 proteinopathy phenotypes","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/selective-vulnerability-validation-of-atypical-neurodegenerative-38cff4ba","doi":"10.21203/rs.3.rs-11296547/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11296547/v1","study_design":null,"title":"Selective vulnerability: validation of atypical neurodegenerative disease variants in histopathological reference cohorts","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/intrastriatal-injection-of-amplified-lewy-body-dementia-lbd-fibrils-5a084b25","doi":"10.64898/2026.10.06.757103","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.06.757103","study_design":null,"title":"Intrastriatal injection of amplified Lewy body dementia (LBD) fibrils in mice results in accumulation of fibrils with LBD structure and neurodegeneration","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/synuclein-seeding-activity-in-fixed-antemortem-skin-biopsies-from-b7f39e6b","doi":"10.21203/rs.3.rs-10953905/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10953905/v1","study_design":null,"title":"\u03b1-Synuclein Seeding Activity in Fixed Antemortem Skin Biopsies From Patients With Synucleinopathies","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/asc-specks-and-synuclein-amplify-microglial-nlrp3-inflammasome-ca6358d7","doi":"10.64898/2026.10.02.756339","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.02.756339","study_design":null,"title":"ASC specks and \u03b1-synuclein amplify microglial NLRP3 inflammasome activation and co-localize with Lewy body pathology","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-machine-learning-based-framework-for-differential-screening-of-6ddf0c22","doi":"10.21203/rs.3.rs-10815316/v1","journal":"Research Square","n_participants":932,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10815316/v1","study_design":null,"title":"A Machine Learning-Based Framework for differential screening of Neurodegenerative Dementias using routine clinical data","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/neuroimaging-of-affective-symptoms-in-lewy-body-dementia-a-systematic-3b0fff6b","doi":"10.21203/rs.3.rs-7472898/v2","journal":"Research Square","n_participants":785,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-7472898/v2","study_design":"systematic review","title":"Neuroimaging of affective symptoms in Lewy body dementia: A systematic review","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/early-prediction-of-parkinsons-disease-progression-by-integrating-5ca208fc","doi":"10.64898/2026.07.07.26357483","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.07.26357483","study_design":"longitudinal study","title":"Early Prediction of Parkinson\u2019s Disease Progression by Integrating Research Cohort and Real-World Data Using Knowledge-Anchored Graph Learning","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/can-objective-measures-of-physical-activity-and-sleep-serve-as-early-4a125473","doi":"10.64898/2025.12.12.25342162","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2025.12.12.25342162","study_design":null,"title":"Can objective measures of physical activity and sleep serve as early predictors of dementia among individuals with cognitive impairment?","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/phenome-wide-and-proteomic-analysis-of-apoe-alleles-across-different-600a905d","doi":"10.64898/2026.09.26.26364080","journal":"medRxiv","n_participants":181880,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.26.26364080","study_design":null,"title":"Phenome-wide and proteomic analysis of APOE alleles across different ancestries in the All of Us Research Program","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/dna-methylation-concordance-between-fresh-frozen-and-formalin-fixed-0316398d","doi":"10.20944/preprints202609.2166.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202609.2166.v1","study_design":null,"title":"DNA Methylation Concordance Between Fresh-Frozen and Formalin-Fixed Paraffin-Embedded Human Brain Tissue in Neurodegenerative Diseases","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/distinguishing-parkinsonian-disorders-and-cognitive-disorder-subtypes-c4b9a721","doi":"10.20944/preprints202609.1308.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202609.1308.v1","study_design":null,"title":"Distinguishing Parkinsonian Disorders and Cognitive Disorder Subtypes Using Pseudocontinuous Arterial Spin Labeling","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-ywhag-nptx2-ratio-predicts-clinical-severity-and-4579e717","doi":"10.64898/2026.08.22.746470","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.22.746470","study_design":null,"title":"Cerebrospinal fluid YWHAG:NPTX2 ratio predicts clinical severity and future phenoconversion in frontotemporal lobar degeneration","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/disease-specific-tangle-immunophenotypes-distinguish-hippocampal-ff9cb4d7","doi":"10.64898/2026.08.13.744594","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.13.744594","study_design":null,"title":"Disease-specific tangle immunophenotypes distinguish hippocampal vulnerability in Alzheimer\u2019s disease and Parkinson\u2019s disease dementia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/neuroinflammation-is-an-early-pathological-process-in-a-mouse-model-398d9a8d","doi":"10.64898/2026.10.29.762888","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.29.762888","study_design":null,"title":"Neuroinflammation is an early pathological process in a mouse model of prodromal Parkinsons disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/limbic-vulnerability-characterises-rem-sleep-behaviour-disorder-ace85e9d","doi":"10.21203/rs.3.rs-11109305/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11109305/v1","study_design":null,"title":"Limbic Vulnerability Characterises REM Sleep Behaviour Disorder Across Prodromal and Established Lewy Body Disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/digital-motor-and-cognitive-variability-as-early-markers-of-the-da109d97","doi":"10.64898/2026.09.06.26358479","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.06.26358479","study_design":"longitudinal study","title":"Digital motor and cognitive variability as early markers of the prodromal Parkinson\u2019s disease spectrum","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-differentiate-parkinsons-disease-from-atypical-29755341","doi":"10.3389/fnagi.2018.00123","journal":"Frontiers in Aging Neuroscience","n_participants":204,"pmid":"29755341","source_url":"https://pubmed.ncbi.nlm.nih.gov/29755341/","study_design":null,"title":"Plasma Biomarkers Differentiate Parkinson\u2019s Disease From Atypical Parkinsonism Syndromes","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/synuclein-membrane-interactions-and-lipid-specificity-10915790","doi":"10.1074/jbc.m004345200","journal":"Journal of Biological Chemistry","n_participants":null,"pmid":"10915790","source_url":"https://pubmed.ncbi.nlm.nih.gov/10915790/","study_design":null,"title":"\u03b1-Synuclein Membrane Interactions and Lipid Specificity","title_match":true,"year":2000},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/proteomic-identification-of-novel-proteins-in-cortical-lewy-bodies-17388944","doi":"10.1111/j.1750-3639.2007.00048.x","journal":"Brain Pathology","n_participants":null,"pmid":"17388944","source_url":"https://pubmed.ncbi.nlm.nih.gov/17388944/","study_design":null,"title":"Proteomic Identification of Novel Proteins in Cortical Lewy Bodies","title_match":true,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/rem-sleep-behavior-disorder-in-parkinsons-disease-and-dementia-with-15312278","doi":"10.1177/0891988704267465","journal":"Journal of Geriatric Psychiatry and Neurology","n_participants":null,"pmid":"15312278","source_url":"https://pubmed.ncbi.nlm.nih.gov/15312278/","study_design":null,"title":"REM Sleep Behavior Disorder in Parkinson\u2019s Disease and Dementia with Lewy Bodies","title_match":true,"year":2004},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/saccadic-eye-movement-changes-in-parkinson-s-disease-dementia-and-15774501","doi":"10.1093/brain/awh484","journal":"Brain","n_participants":20,"pmid":"15774501","source_url":"https://pubmed.ncbi.nlm.nih.gov/15774501/","study_design":null,"title":"Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies","title_match":true,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/donepezil-an-update-17472546","doi":"10.1517/14656566.8.7.1011","journal":"Expert Opinion on Pharmacotherapy","n_participants":null,"pmid":"17472546","source_url":"https://pubmed.ncbi.nlm.nih.gov/17472546/","study_design":null,"title":"Donepezil: an update","title_match":false,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/donepezil-for-treatment-of-dementia-with-lewy-bodies-a-case-series-of-9785144","doi":"10.1017/s1041610298005341","journal":"International Psychogeriatrics","n_participants":null,"pmid":"9785144","source_url":"https://pubmed.ncbi.nlm.nih.gov/9785144/","study_design":null,"title":"Donepezil for Treatment of Dementia With Lewy Bodies: A Case Series of Nine Patients","title_match":true,"year":1998},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/rem-sleep-behavior-disorder-and-degenerative-dementia-9710004","doi":"10.1212/wnl.51.2.363","journal":"Neurology","n_participants":37,"pmid":"9710004","source_url":"https://pubmed.ncbi.nlm.nih.gov/9710004/","study_design":null,"title":"REM sleep behavior disorder and degenerative dementia","title_match":false,"year":1998},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/synucleinopathy-pathology-and-rem-sleep-behavior-disorder-plus-12847154","doi":"10.1212/01.wnl.0000073619.94467.b0","journal":"Neurology","n_participants":null,"pmid":"12847154","source_url":"https://pubmed.ncbi.nlm.nih.gov/12847154/","study_design":null,"title":"Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism","title_match":false,"year":2003},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/progressive-posterior-cortical-dysfunction-15477534","doi":"10.1212/01.wnl.0000140290.80962.bf","journal":"Neurology","n_participants":13,"pmid":"15477534","source_url":"https://pubmed.ncbi.nlm.nih.gov/15477534/","study_design":null,"title":"Progressive posterior cortical dysfunction","title_match":false,"year":2004},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/epidemiology-of-early-onset-dementia-a-review-of-the-literature-23878613","doi":"10.2174/1745017901309010088","journal":"Clinical Practice and Epidemiology in Mental Health","n_participants":null,"pmid":"23878613","source_url":"https://pubmed.ncbi.nlm.nih.gov/23878613/","study_design":null,"title":"Epidemiology of early-onset dementia: a review of the literature","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/chip-and-hsp70-regulate-tau-ubiquitination-degradation-and-aggregation-14962978","doi":"10.1093/hmg/ddh083","journal":"Human Molecular Genetics","n_participants":null,"pmid":"14962978","source_url":"https://pubmed.ncbi.nlm.nih.gov/14962978/","study_design":null,"title":"CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation","title_match":false,"year":2004},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/glial-cytoplasmic-inclusions-in-white-matter-oligodendrocytes-of-9749615","doi":"10.1002/ana.410440324","journal":"Annals of Neurology","n_participants":null,"pmid":"9749615","source_url":"https://pubmed.ncbi.nlm.nih.gov/9749615/","study_design":null,"title":"Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble \u03b1\u2010synuclein","title_match":false,"year":1998},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/synuclein-shares-physical-and-functional-homology-with-14-3-3-proteins-10407019","doi":"10.1523/jneurosci.19-14-05782.1999","journal":"Journal of Neuroscience","n_participants":null,"pmid":"10407019","source_url":"https://pubmed.ncbi.nlm.nih.gov/10407019/","study_design":null,"title":"\u03b1-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins","title_match":true,"year":1999},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/a-broken-helix-in-folded-synuclein-12586824","doi":"10.1074/jbc.m213128200","journal":"Journal of Biological Chemistry","n_participants":null,"pmid":"12586824","source_url":"https://pubmed.ncbi.nlm.nih.gov/12586824/","study_design":null,"title":"A Broken \u03b1-Helix in Folded \u03b1-Synuclein","title_match":true,"year":2003},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/invited-article-nervous-system-pathology-in-sporadic-parkinson-disease-18474848","doi":"10.1212/01.wnl.0000312279.49272.9f","journal":"Neurology","n_participants":null,"pmid":"18474848","source_url":"https://pubmed.ncbi.nlm.nih.gov/18474848/","study_design":null,"title":"Invited Article: Nervous system pathology in sporadic Parkinson disease","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/lewy-bodies-contain-altered-synuclein-in-brains-of-many-familial-9811326","doi":"10.1016/s0002-9440(10)65722-7","journal":"American Journal Of Pathology","n_participants":65,"pmid":"9811326","source_url":"https://pubmed.ncbi.nlm.nih.gov/9811326/","study_design":null,"title":"Lewy Bodies Contain Altered \u03b1-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes","title_match":true,"year":1998},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/detection-of-elevated-levels-of-synuclein-oligomers-in-csf-from-20962290","doi":"10.1212/wnl.0b013e3181fd613b","journal":"Neurology","n_participants":32,"pmid":"20962290","source_url":"https://pubmed.ncbi.nlm.nih.gov/20962290/","study_design":"cross-sectional","title":"Detection of elevated levels of \u03b1-synuclein oligomers in CSF from patients with Parkinson disease","title_match":true,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/raman-spectroscopic-characterization-of-secondary-structure-in-14982446","doi":"10.1021/ja0356176","journal":"Journal of the American Chemical Society","n_participants":null,"pmid":"14982446","source_url":"https://pubmed.ncbi.nlm.nih.gov/14982446/","study_design":null,"title":"Raman Spectroscopic Characterization of Secondary Structure in Natively Unfolded Proteins: \u03b1-Synuclein","title_match":true,"year":2004},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/assessing-the-stability-of-alzheimers-amyloid-protofibrils-using-20055378","doi":"10.1021/jp9110794","journal":"The Journal of Physical Chemistry B","n_participants":null,"pmid":"20055378","source_url":"https://pubmed.ncbi.nlm.nih.gov/20055378/","study_design":null,"title":"Assessing the Stability of Alzheimer\u2019s Amyloid Protofibrils Using Molecular Dynamics","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/hsp70-reduces-synuclein-aggregation-and-toxicity-15044495","doi":"10.1074/jbc.m400255200","journal":"Journal of Biological Chemistry","n_participants":null,"pmid":"15044495","source_url":"https://pubmed.ncbi.nlm.nih.gov/15044495/","study_design":null,"title":"Hsp70 Reduces \u03b1-Synuclein Aggregation and Toxicity","title_match":true,"year":2004},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-induced-pluripotent-stem-cells-with-triplication-21863007","doi":"10.1038/ncomms1453","journal":"Nature Communications","n_participants":null,"pmid":"21863007","source_url":"https://pubmed.ncbi.nlm.nih.gov/21863007/","study_design":null,"title":"Parkinson's disease induced pluripotent stem cells with triplication of the \u03b1-synuclein locus","title_match":true,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/anle138b-a-novel-oligomer-modulator-for-disease-modifying-therapy-of-23604588","doi":"10.1007/s00401-013-1114-9","journal":"Acta Neuropathologica","n_participants":null,"pmid":"23604588","source_url":"https://pubmed.ncbi.nlm.nih.gov/23604588/","study_design":null,"title":"Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson\u2019s disease","title_match":false,"year":2013},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/classification-and-pathology-of-primary-progressive-aphasia-24142474","doi":"10.1212/01.wnl.0000436070.28137.7b","journal":"Neurology","n_participants":52,"pmid":"24142474","source_url":"https://pubmed.ncbi.nlm.nih.gov/24142474/","study_design":null,"title":"Classification and pathology of primary progressive aphasia","title_match":false,"year":2013},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/widespread-transneuronal-propagation-of-synucleinopathy-triggered-in-27503075","doi":"10.1084/jem.20160368","journal":"The Journal of Experimental Medicine","n_participants":null,"pmid":"27503075","source_url":"https://pubmed.ncbi.nlm.nih.gov/27503075/","study_design":null,"title":"Widespread transneuronal propagation of \u03b1-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson\u2019s disease","title_match":true,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/donepezil-for-dementia-with-lewy-bodies-a-randomized-placebo-044b4853","doi":"10.1186/s13195-014-0083-0","journal":"Alzheimer's Research & Therapy","n_participants":142,"pmid":null,"source_url":"https://doi.org/10.1186/s13195-014-0083-0","study_design":null,"title":"Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial","title_match":true,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/long-term-donepezil-use-for-dementia-with-lewy-bodies-results-from-an-88c17657","doi":"10.1186/s13195-014-0081-2","journal":"Alzheimer's Research & Therapy","n_participants":100,"pmid":null,"source_url":"https://doi.org/10.1186/s13195-014-0081-2","study_design":"clinical trial","title":"Long-term donepezil use for dementia with Lewy bodies: results from an open-label extension of Phase III trial","title_match":true,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/sleep-related-behaviors-in-alzheimers-disease-and-dementia-with-lewy-e57fb311","doi":"10.1515/revneuro-2014-0050","journal":"Reviews in the Neurosciences","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1515/revneuro-2014-0050","study_design":"narrative review","title":"Sleep-related behaviors in Alzheimer\u2019s disease and dementia with Lewy bodies","title_match":true,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/electroencephalographic-finding-in-idiopathic-rem-sleep-behavior-b7fa48f7","doi":"10.1159/000363343","journal":"Neuropsychobiology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1159/000363343","study_design":"longitudinal study","title":"Electroencephalographic Finding in Idiopathic REM Sleep Behavior Disorder","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/targeting-hsp90-hsp70-based-protein-quality-control-for-treatment-of-6e8cc850","doi":"10.1146/annurev-pharmtox-010814-124332","journal":"Annual Review of Pharmacology and Toxicology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1146/annurev-pharmtox-010814-124332","study_design":null,"title":"Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/elevated-csf-angiopoietin-2-correlates-with-blood-brain-barrier-38182581","doi":"10.1038/s41398-023-02706-w","journal":"Translational psychiatry","n_participants":121,"pmid":"38182581","source_url":"https://pubmed.ncbi.nlm.nih.gov/38182581/","study_design":null,"title":"Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/predictive-value-of-cerebrospinal-fluid-visinin-like-protein-1-levels-26836160","doi":"10.3233/jad-150705","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26836160","source_url":"https://pubmed.ncbi.nlm.nih.gov/26836160/","study_design":null,"title":"Predictive Value of Cerebrospinal Fluid Visinin-Like Protein-1 Levels for Alzheimer's Disease Early Detection and Differential Diagnosis in Patients with Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/associations-between-cerebrospinal-fluid-biomarkers-and-cognition-in-26599300","doi":"10.3233/jpd-150682","journal":"Journal of Parkinson's disease","n_participants":null,"pmid":"26599300","source_url":"https://pubmed.ncbi.nlm.nih.gov/26599300/","study_design":"cohort study","title":"Associations between Cerebrospinal Fluid Biomarkers and Cognition in Early Untreated Parkinson's Disease","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/novel-blood-based-proteomic-signatures-across-multiple-40145305","doi":"10.1002/alz.70116","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":36,"pmid":"40145305","source_url":"https://pubmed.ncbi.nlm.nih.gov/40145305/","study_design":null,"title":"Novel blood-based proteomic signatures across multiple neurodegenerative diseases","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-longitudinal-study-of-total-and-phosphorylated-synuclein-with-other-29376878","doi":"10.3233/jad-171013","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29376878","source_url":"https://pubmed.ncbi.nlm.nih.gov/29376878/","study_design":"longitudinal study","title":"A Longitudinal Study of Total and Phosphorylated \u03b1-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment","title_match":true,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/biomarker-discovery-in-alzheimer-s-and-neurodegenerative-diseases-40401628","doi":"10.1002/alz.14621","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40401628","source_url":"https://pubmed.ncbi.nlm.nih.gov/40401628/","study_design":null,"title":"Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-amyloid-tau-axonal-and-neuroinflammation-38961441","doi":"10.1186/s13195-024-01502-y","journal":"Alzheimer's research & therapy","n_participants":104,"pmid":"38961441","source_url":"https://pubmed.ncbi.nlm.nih.gov/38961441/","study_design":null,"title":"Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies","title_match":true,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/csf-beta-amyloid-1-42-what-are-we-measuring-in-alzheimer-s-disease-25750918","doi":"10.1002/acn3.160","journal":"Annals of clinical and translational neurology","n_participants":69,"pmid":"25750918","source_url":"https://pubmed.ncbi.nlm.nih.gov/25750918/","study_design":null,"title":"CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease?","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-gfap-associates-with-secondary-alzheimer-s-pathology-in-lewy-37000892","doi":"10.1002/acn3.51768","journal":"Annals of clinical and translational neurology","n_participants":19,"pmid":"37000892","source_url":"https://pubmed.ncbi.nlm.nih.gov/37000892/","study_design":null,"title":"Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease","title_match":true,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neuropathological-changes-associated-with-aberrant-cerebrospinal-38539238","doi":"10.1186/s40478-024-01758-3","journal":"Acta neuropathologica communications","n_participants":22,"pmid":"38539238","source_url":"https://pubmed.ncbi.nlm.nih.gov/38539238/","study_design":null,"title":"Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and A\u03b242 in Alzheimer's disease and other neurodegenerative diseases","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/does-csf-p-tau181-help-to-discriminate-alzheimer-s-disease-from-other-24817210","doi":"10.1007/s00702-014-1226-y","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"24817210","source_url":"https://pubmed.ncbi.nlm.nih.gov/24817210/","study_design":"meta-analysis","title":"Does CSF p-tau181 help to discriminate Alzheimer's disease from other dementias and mild cognitive impairment? A meta-analysis of the literature","title_match":false,"year":2014},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-the-diagnosis-of-neurodegenerative-dementia-a-36423207","doi":"10.1177/08919887221141651","journal":"Journal of geriatric psychiatry and neurology","n_participants":null,"pmid":"36423207","source_url":"https://pubmed.ncbi.nlm.nih.gov/36423207/","study_design":"systematic review","title":"Blood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/default-mode-network-connectivity-is-linked-to-cognitive-functioning-26515126","doi":"10.1016/j.archger.2015.09.010","journal":"Archives of gerontology and geriatrics","n_participants":21,"pmid":"26515126","source_url":"https://pubmed.ncbi.nlm.nih.gov/26515126/","study_design":null,"title":"Default mode network connectivity is linked to cognitive functioning and CSF A\u03b21-42 levels in Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/development-of-thresholds-and-a-visualization-tool-for-use-of-a-blood-39096164","doi":"10.1002/alz.14088","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1199,"pmid":"39096164","source_url":"https://pubmed.ncbi.nlm.nih.gov/39096164/","study_design":null,"title":"Development of thresholds and a visualization tool for use of a blood test in routine clinical dementia practice","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-ev-concentration-and-size-are-altered-in-35159272","doi":"10.3390/cells11030462","journal":"Cells","n_participants":120,"pmid":"35159272","source_url":"https://pubmed.ncbi.nlm.nih.gov/35159272/","study_design":null,"title":"Cerebrospinal Fluid EV Concentration and Size Are Altered in Alzheimer's Disease and Dementia with Lewy Bodies","title_match":true,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-concentrations-of-inflammatory-markers-in-30185816","doi":"10.1038/s41598-018-31517-z","journal":"Scientific reports","n_participants":131,"pmid":"30185816","source_url":"https://pubmed.ncbi.nlm.nih.gov/30185816/","study_design":null,"title":"Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disorders","title_match":false,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-oligomers-and-neurofilament-light-chain-in-spinal-32557811","doi":"10.1002/ana.25824","journal":"Annals of neurology","n_participants":24,"pmid":"32557811","source_url":"https://pubmed.ncbi.nlm.nih.gov/32557811/","study_design":null,"title":"Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies","title_match":true,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/csf-serum-albumin-ratio-in-dementias-a-cross-sectional-study-on-1861-28779628","doi":"10.1016/j.neurobiolaging.2017.06.028","journal":"Neurobiology of aging","n_participants":130,"pmid":"28779628","source_url":"https://pubmed.ncbi.nlm.nih.gov/28779628/","study_design":null,"title":"CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/cytokine-production-of-activated-microglia-and-decrease-in-15619128","doi":"10.1007/s00401-004-0919-y","journal":"Acta neuropathologica","n_participants":null,"pmid":"15619128","source_url":"https://pubmed.ncbi.nlm.nih.gov/15619128/","study_design":null,"title":"Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains","title_match":true,"year":2005},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/diversity-of-astroglial-responses-across-human-neurodegenerative-28804999","doi":"10.1111/bpa.12538","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"28804999","source_url":"https://pubmed.ncbi.nlm.nih.gov/28804999/","study_design":null,"title":"Diversity of astroglial responses across human neurodegenerative disorders and brain aging","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-inflammatory-marker-ykl-40-is-elevated-in-cerebrospinal-fluid-26270969","doi":"10.1371/journal.pone.0135458","journal":"PloS one","n_participants":49,"pmid":"26270969","source_url":"https://pubmed.ncbi.nlm.nih.gov/26270969/","study_design":null,"title":"The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer's but Not Parkinson's Disease or Dementia with Lewy Bodies","title_match":true,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/icariside-ii-attenuates-lipopolysaccharide-induced-neuroinflammation-30590319","doi":"10.1016/j.biopha.2018.10.201","journal":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","n_participants":null,"pmid":"30590319","source_url":"https://pubmed.ncbi.nlm.nih.gov/30590319/","study_design":null,"title":"Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-\u03baB pathway in rats","title_match":false,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-oligomers-and-neurofilament-light-chain-predict-33881777","doi":"10.1002/ana.26089","journal":"Annals of neurology","n_participants":32,"pmid":"33881777","source_url":"https://pubmed.ncbi.nlm.nih.gov/33881777/","study_design":null,"title":"Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure","title_match":true,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-csf-neurofilament-light-signature-in-rapidly-progressive-29368621","doi":"10.1186/s13195-017-0331-1","journal":"Alzheimer's research & therapy","n_participants":141,"pmid":"29368621","source_url":"https://pubmed.ncbi.nlm.nih.gov/29368621/","study_design":null,"title":"The CSF neurofilament light signature in rapidly progressive neurodegenerative dementias","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/nitration-in-neurodegeneration-deciphering-the-hows-nys-17542619","doi":"10.1021/bi700430y","journal":"Biochemistry","n_participants":null,"pmid":"17542619","source_url":"https://pubmed.ncbi.nlm.nih.gov/17542619/","study_design":null,"title":"Nitration in neurodegeneration: deciphering the \"Hows\" \"nYs\"","title_match":false,"year":2007},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/csf-or-serum-neurofilament-light-added-to-synuclein-panel-31737952","doi":"10.1002/mds.27897","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"31737952","source_url":"https://pubmed.ncbi.nlm.nih.gov/31737952/","study_design":null,"title":"CSF or serum neurofilament light added to \u03b1-Synuclein panel discriminates Parkinson's from controls","title_match":true,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-neurofilament-light-levels-in-neurodegenerative-29391125","doi":"10.1016/j.jalz.2017.12.008","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":122,"pmid":"29391125","source_url":"https://pubmed.ncbi.nlm.nih.gov/29391125/","study_design":null,"title":"Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases","title_match":false,"year":2018},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/optimal-combinations-of-csf-biomarkers-for-predicting-cognitive-36648169","doi":"10.1002/alz.12907","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1983,"pmid":"36648169","source_url":"https://pubmed.ncbi.nlm.nih.gov/36648169/","study_design":"longitudinal study","title":"Optimal combinations of CSF biomarkers for predicting cognitive decline and clinical conversion in cognitively unimpaired participants and mild cognitive impairment patients: A multi-cohort study","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-cerebrospinal-fluid-biomarkers-phospho-tau181-26923009","doi":"10.3233/jad-150731","journal":"Journal of Alzheimer's disease : JAD","n_participants":166,"pmid":"26923009","source_url":"https://pubmed.ncbi.nlm.nih.gov/26923009/","study_design":null,"title":"Diagnostic Value of Cerebrospinal Fluid Biomarkers (Phospho-Tau181, total-Tau, A\u03b242, and A\u03b240) in Prodromal Stage of Alzheimer's Disease and Dementia with Lewy Bodies","title_match":true,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/csf-amyloid-38-as-a-novel-diagnostic-marker-for-dementia-with-lewy-21047883","doi":"10.1136/jnnp.2009.199398","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":85,"pmid":"21047883","source_url":"https://pubmed.ncbi.nlm.nih.gov/21047883/","study_design":null,"title":"CSF amyloid \u03b238 as a novel diagnostic marker for dementia with Lewy bodies","title_match":true,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/enhanced-accumulation-of-phosphorylated-alpha-synuclein-and-elevated-18045903","doi":"10.1523/jneurosci.4244-07.2007","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"18045903","source_url":"https://pubmed.ncbi.nlm.nih.gov/18045903/","study_design":null,"title":"Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease","title_match":true,"year":2007},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-t-n-profile-in-cerebrospinal-fluid-of-parkinson-s-disease-with-33256252","doi":"10.3390/diagnostics10121015","journal":"Diagnostics (Basel, Switzerland)","n_participants":null,"pmid":"33256252","source_url":"https://pubmed.ncbi.nlm.nih.gov/33256252/","study_design":null,"title":"A/T/(N) Profile in Cerebrospinal Fluid of Parkinson's Disease with/without Cognitive Impairment and Dementia with Lewy Bodies","title_match":true,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/diagnosis-of-neurodegenerative-dementia-where-do-we-stand-now-30306079","doi":"10.21037/atm.2018.08.04","journal":"Annals of translational medicine","n_participants":null,"pmid":"30306079","source_url":"https://pubmed.ncbi.nlm.nih.gov/30306079/","study_design":null,"title":"Diagnosis of neurodegenerative dementia: where do we stand, now?","title_match":false,"year":2018},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/novel-fluid-biomarkers-to-differentiate-frontotemporal-dementia-and-32428759","doi":"10.1016/j.jns.2020.116886","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"32428759","source_url":"https://pubmed.ncbi.nlm.nih.gov/32428759/","study_design":"systematic review","title":"Novel fluid biomarkers to differentiate frontotemporal dementia and dementia with Lewy bodies from Alzheimer's disease: A systematic review","title_match":true,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/amyloid-related-cerebral-microbleed-and-plasma-a40-are-associated-33782518","doi":"10.1038/s41598-021-86617-0","journal":"Scientific reports","n_participants":135,"pmid":"33782518","source_url":"https://pubmed.ncbi.nlm.nih.gov/33782518/","study_design":null,"title":"Amyloid related cerebral microbleed and plasma A\u03b240 are associated with cognitive decline in Parkinson's disease","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/molecular-mechanisms-and-biomarkers-in-neurodegenerative-disorders-a-40138119","doi":"10.1007/s11033-025-10463-w","journal":"Molecular biology reports","n_participants":null,"pmid":"40138119","source_url":"https://pubmed.ncbi.nlm.nih.gov/40138119/","study_design":"longitudinal study","title":"Molecular mechanisms and biomarkers in neurodegenerative disorders: a comprehensive review","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/plasma-ptau181-reveals-a-pathological-signature-that-predicts-38888142","doi":"10.1002/ana.27003","journal":"Annals of neurology","n_participants":565,"pmid":"38888142","source_url":"https://pubmed.ncbi.nlm.nih.gov/38888142/","study_design":"longitudinal study","title":"Plasma pTau181 Reveals a Pathological Signature that Predicts Cognitive Outcomes in Lewy Body Disease","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/csf-metabolites-associated-with-biomarkers-of-alzheimer-s-disease-37719875","doi":"10.3389/fnagi.2023.1214932","journal":"Frontiers in aging neuroscience","n_participants":161,"pmid":"37719875","source_url":"https://pubmed.ncbi.nlm.nih.gov/37719875/","study_design":null,"title":"CSF metabolites associated with biomarkers of Alzheimer's disease pathology","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/cognitively-unimpaired-individuals-with-a-low-burden-of-a-pathology-34315519","doi":"10.1186/s13195-021-00863-y","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"34315519","source_url":"https://pubmed.ncbi.nlm.nih.gov/34315519/","study_design":"cross-sectional","title":"Cognitively unimpaired individuals with a low burden of A\u03b2 pathology have a distinct CSF biomarker profile","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-total-prion-protein-as-a-potential-biomarker-for-31216593","doi":"10.1111/nan.12573","journal":"Neuropathology and applied neurobiology","n_participants":520,"pmid":"31216593","source_url":"https://pubmed.ncbi.nlm.nih.gov/31216593/","study_design":null,"title":"Plasma total prion protein as a potential biomarker for neurodegenerative dementia: diagnostic accuracy in the spectrum of prion diseases","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/platelet-immunoglobulin-and-amyloid-precursor-protein-as-potential-22258116","doi":"10.1093/ageing/afr171","journal":"Age and ageing","n_participants":null,"pmid":"22258116","source_url":"https://pubmed.ncbi.nlm.nih.gov/22258116/","study_design":null,"title":"Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study","title_match":false,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/peripheral-innate-immunophenotype-in-neurodegenerative-disease-blood-39472664","doi":"10.1038/s41380-024-02809-w","journal":"Molecular psychiatry","n_participants":148,"pmid":"39472664","source_url":"https://pubmed.ncbi.nlm.nih.gov/39472664/","study_design":null,"title":"Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/erythrocytes-as-biomarkers-for-dementia-analysis-of-protein-content-31424413","doi":"10.3233/jad-190567","journal":"Journal of Alzheimer's disease : JAD","n_participants":114,"pmid":"31424413","source_url":"https://pubmed.ncbi.nlm.nih.gov/31424413/","study_design":null,"title":"Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein","title_match":true,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/parkinson-s-progression-markers-initiative-brain-autopsy-program-35803091","doi":"10.1016/j.parkreldis.2022.06.017","journal":"Parkinsonism & related disorders","n_participants":15,"pmid":"35803091","source_url":"https://pubmed.ncbi.nlm.nih.gov/35803091/","study_design":"longitudinal study","title":"Parkinson's Progression Markers Initiative brain autopsy program","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/direct-quantification-of-csf-alpha-synuclein-by-elisa-and-first-cross-18625222","doi":"10.1016/j.expneurol.2008.06.004","journal":"Experimental neurology","n_participants":57,"pmid":"18625222","source_url":"https://pubmed.ncbi.nlm.nih.gov/18625222/","study_design":"cross-sectional","title":"Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration","title_match":true,"year":2008},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/autophagy-inhibition-promotes-snca-alpha-synuclein-release-and-29198173","doi":"10.1080/15548627.2017.1395992","journal":"Autophagy","n_participants":null,"pmid":"29198173","source_url":"https://pubmed.ncbi.nlm.nih.gov/29198173/","study_design":null,"title":"Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype","title_match":true,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/seed-amplification-assay-for-the-detection-of-pathologic-alpha-36653527","doi":"10.1038/s41596-022-00787-3","journal":"Nature protocols","n_participants":null,"pmid":"36653527","source_url":"https://pubmed.ncbi.nlm.nih.gov/36653527/","study_design":null,"title":"Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid","title_match":true,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/4-hydroxynonenal-and-neurodegenerative-diseases-12893007","doi":"10.1016/s0098-2997(03)00024-4","journal":"Molecular aspects of medicine","n_participants":null,"pmid":"12893007","source_url":"https://pubmed.ncbi.nlm.nih.gov/12893007/","study_design":null,"title":"4-hydroxynonenal and neurodegenerative diseases","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/standardization-of-measurement-of-beta-amyloid-1-42-in-cerebrospinal-11132093","doi":"10.3109/13506120009146438","journal":"Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis","n_participants":null,"pmid":"11132093","source_url":"https://pubmed.ncbi.nlm.nih.gov/11132093/","study_design":null,"title":"Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma","title_match":false,"year":2000},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/increased-blood-brain-barrier-permeability-is-associated-with-28061383","doi":"10.1016/j.neurobiolaging.2016.11.017","journal":"Neurobiology of aging","n_participants":1015,"pmid":"28061383","source_url":"https://pubmed.ncbi.nlm.nih.gov/28061383/","study_design":null,"title":"Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype","title_match":false,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/efns-ens-guidelines-on-the-diagnosis-and-management-of-disorders-22891773","doi":"10.1111/j.1468-1331.2012.03784.x","journal":"European journal of neurology","n_participants":null,"pmid":"22891773","source_url":"https://pubmed.ncbi.nlm.nih.gov/22891773/","study_design":"meta-analysis","title":"EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia","title_match":false,"year":2012},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/nilotinib-effects-in-parkinson-s-disease-and-dementia-with-lewy-bodies-27434297","doi":"10.3233/jpd-160867","journal":"Journal of Parkinson's disease","n_participants":null,"pmid":"27434297","source_url":"https://pubmed.ncbi.nlm.nih.gov/27434297/","study_design":null,"title":"Nilotinib Effects in Parkinson's disease and Dementia with Lewy bodies","title_match":true,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/significance-and-confounders-of-peripheral-dj-1-and-alpha-synuclein-20540987","doi":"10.1016/j.neulet.2010.06.009","journal":"Neuroscience letters","n_participants":null,"pmid":"20540987","source_url":"https://pubmed.ncbi.nlm.nih.gov/20540987/","study_design":null,"title":"Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease","title_match":true,"year":2010},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/cognitive-training-and-promoting-a-healthy-lifestyle-for-individuals-38943191","doi":"10.1186/s13063-024-08265-9","journal":"Trials","n_participants":null,"pmid":"38943191","source_url":"https://pubmed.ncbi.nlm.nih.gov/38943191/","study_design":"randomized controlled trial","title":"Cognitive training and promoting a healthy lifestyle for individuals with isolated REM sleep behavior disorder: study protocol of the delayed-start randomized controlled trial CogTrAiL-RBD","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/rhythmic-auditory-cueing-in-atypical-parkinsonism-a-pilot-study-36388209","doi":"10.3389/fneur.2022.1018206","journal":"Frontiers in neurology","n_participants":46,"pmid":"36388209","source_url":"https://pubmed.ncbi.nlm.nih.gov/36388209/","study_design":null,"title":"Rhythmic auditory cueing in atypical parkinsonism: A pilot study","title_match":false,"year":2022},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/diagnosis-accuracy-of-touchscreen-based-testings-for-major-40742248","doi":"10.1093/ageing/afaf204","journal":"Age and ageing","n_participants":null,"pmid":"40742248","source_url":"https://pubmed.ncbi.nlm.nih.gov/40742248/","study_design":"systematic review","title":"Diagnosis accuracy of touchscreen-based testings for major neurocognitive disorders: a systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/modification-of-brain-aging-and-neurodegenerative-disorders-by-genes-12087131","doi":"10.1152/physrev.00004.2002","journal":"Physiological reviews","n_participants":null,"pmid":"12087131","source_url":"https://pubmed.ncbi.nlm.nih.gov/12087131/","study_design":null,"title":"Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior","title_match":false,"year":2002},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-immunoreactive-cortical-lewy-bodies-are-associated-10965798","doi":"10.1007/s004019900168","journal":"Acta neuropathologica","n_participants":45,"pmid":"10965798","source_url":"https://pubmed.ncbi.nlm.nih.gov/10965798/","study_design":null,"title":"Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease","title_match":true,"year":2000},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/covid-19-and-risk-of-neurodegenerative-disorders-a-mendelian-35835752","doi":"10.1038/s41398-022-02052-3","journal":"Translational psychiatry","n_participants":null,"pmid":"35835752","source_url":"https://pubmed.ncbi.nlm.nih.gov/35835752/","study_design":null,"title":"COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/mendelian-randomization-study-of-pcsk9-and-hmg-coa-reductase-35953131","doi":"10.1016/j.jacc.2022.05.041","journal":"Journal of the American College of Cardiology","n_participants":740000,"pmid":"35953131","source_url":"https://pubmed.ncbi.nlm.nih.gov/35953131/","study_design":null,"title":"Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/tau-in-the-pathophysiology-of-parkinson-s-disease-33459970","doi":"10.1007/s12031-020-01776-5","journal":"Journal of molecular neuroscience : MN","n_participants":null,"pmid":"33459970","source_url":"https://pubmed.ncbi.nlm.nih.gov/33459970/","study_design":null,"title":"Tau in the Pathophysiology of Parkinson's Disease","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/synuclein-bac-transgenic-mice-exhibit-rbd-like-behaviour-and-hyposmia-31816026","doi":"10.1093/brain/awz380","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"31816026","source_url":"https://pubmed.ncbi.nlm.nih.gov/31816026/","study_design":null,"title":"\u03b1-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-genetics-of-dementia-with-lewy-bodies-current-understanding-and-30097731","doi":"10.1007/s11910-018-0874-y","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"30097731","source_url":"https://pubmed.ncbi.nlm.nih.gov/30097731/","study_design":null,"title":"The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions","title_match":true,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/susceptibility-to-neurofibrillary-tangles-role-of-the-ptprd-locus-and-28322283","doi":"10.1038/mp.2017.20","journal":"Molecular psychiatry","n_participants":null,"pmid":"28322283","source_url":"https://pubmed.ncbi.nlm.nih.gov/28322283/","study_design":null,"title":"Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies","title_match":false,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/gba-and-apoe-4-associate-with-sporadic-dementia-with-lewy-bodies-in-31065058","doi":"10.1038/s41598-019-43458-2","journal":"Scientific reports","n_participants":19,"pmid":"31065058","source_url":"https://pubmed.ncbi.nlm.nih.gov/31065058/","study_design":null,"title":"GBA and APOE \u03b54 associate with sporadic dementia with Lewy bodies in European genome wide association study","title_match":true,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/up-regulation-of-snca-gene-expression-implications-to-26948950","doi":"10.1007/s10048-016-0478-0","journal":"Neurogenetics","n_participants":null,"pmid":"26948950","source_url":"https://pubmed.ncbi.nlm.nih.gov/26948950/","study_design":null,"title":"Up-regulation of SNCA gene expression: implications to synucleinopathies","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/i-sorl1-i-mutations-in-early-and-late-onset-alzheimer-disease-27822510","doi":"10.1212/nxg.0000000000000116","journal":"Neurology. Genetics","n_participants":null,"pmid":"27822510","source_url":"https://pubmed.ncbi.nlm.nih.gov/27822510/","study_design":null,"title":"SORL1 mutations in early- and late-onset Alzheimer disease","title_match":false,"year":2016},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-synuclein-seeding-activity-and-contributes-to-35471463","doi":"10.1007/s00401-022-02421-8","journal":"Acta neuropathologica","n_participants":469,"pmid":"35471463","source_url":"https://pubmed.ncbi.nlm.nih.gov/35471463/","study_design":null,"title":"APOE4 exacerbates \u03b1-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology","title_match":true,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/link-between-the-snca-gene-and-parkinsonism-25554495","doi":"10.1016/j.neurobiolaging.2014.10.042","journal":"Neurobiology of aging","n_participants":null,"pmid":"25554495","source_url":"https://pubmed.ncbi.nlm.nih.gov/25554495/","study_design":null,"title":"Link between the SNCA gene and parkinsonism","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-evaluation-of-dementia-with-lewy-bodies-implicates-distinct-35381062","doi":"10.1093/brain/awab402","journal":"Brain : a journal of neurology","n_participants":88,"pmid":"35381062","source_url":"https://pubmed.ncbi.nlm.nih.gov/35381062/","study_design":null,"title":"Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/pinpointing-novel-risk-loci-for-lewy-body-dementia-and-the-shared-35729600","doi":"10.1186/s12916-022-02404-2","journal":"BMC medicine","n_participants":null,"pmid":"35729600","source_url":"https://pubmed.ncbi.nlm.nih.gov/35729600/","study_design":null,"title":"Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer's disease and Parkinson's disease: a large-scale multi-trait association analysis","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/different-pattern-of-csf-glial-markers-between-dementia-with-lewy-31127154","doi":"10.1038/s41598-019-44173-8","journal":"Scientific reports","n_participants":37,"pmid":"31127154","source_url":"https://pubmed.ncbi.nlm.nih.gov/31127154/","study_design":null,"title":"Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/striking-while-the-iron-is-hot-iron-metabolism-and-ferroptosis-in-30266679","doi":"10.1016/j.freeradbiomed.2018.09.033","journal":"Free radical biology & medicine","n_participants":null,"pmid":"30266679","source_url":"https://pubmed.ncbi.nlm.nih.gov/30266679/","study_design":null,"title":"Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disease-and-adult-neurogenesis-21395858","doi":"10.1111/j.1460-9568.2011.07613.x","journal":"The European journal of neuroscience","n_participants":null,"pmid":"21395858","source_url":"https://pubmed.ncbi.nlm.nih.gov/21395858/","study_design":null,"title":"Neurodegenerative disease and adult neurogenesis","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-presenilins-and-alpha-synuclein-molecular-12223532","doi":"10.1124/pr.54.3.469","journal":"Pharmacological reviews","n_participants":null,"pmid":"12223532","source_url":"https://pubmed.ncbi.nlm.nih.gov/12223532/","study_design":null,"title":"Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease","title_match":true,"year":2002},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/exosomes-vehicles-for-the-transfer-of-toxic-proteins-associated-with-22563321","doi":"10.3389/fphys.2012.00124","journal":"Frontiers in physiology","n_participants":null,"pmid":"22563321","source_url":"https://pubmed.ncbi.nlm.nih.gov/22563321/","study_design":null,"title":"Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/role-of-protein-aggregation-in-mitochondrial-dysfunction-and-14528050","doi":"10.1385/nmm:4:1-2:21","journal":"Neuromolecular medicine","n_participants":null,"pmid":"14528050","source_url":"https://pubmed.ncbi.nlm.nih.gov/14528050/","study_design":null,"title":"Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/multiple-proteins-implicated-in-neurodegenerative-diseases-accumulate-17826768","doi":"10.1016/j.expneurol.2007.06.018","journal":"Experimental neurology","n_participants":null,"pmid":"17826768","source_url":"https://pubmed.ncbi.nlm.nih.gov/17826768/","study_design":null,"title":"Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans","title_match":false,"year":2007},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/cortical-proteins-associated-with-cognitive-resilience-in-community-32609320","doi":"10.1001/jamapsychiatry.2020.1807","journal":"JAMA psychiatry","n_participants":391,"pmid":"32609320","source_url":"https://pubmed.ncbi.nlm.nih.gov/32609320/","study_design":"longitudinal study","title":"Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/human-dna-methylomes-of-neurodegenerative-diseases-show-common-26784972","doi":"10.1038/tp.2015.214","journal":"Translational psychiatry","n_participants":null,"pmid":"26784972","source_url":"https://pubmed.ncbi.nlm.nih.gov/26784972/","study_design":null,"title":"Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/salivary-biomarkers-for-the-diagnosis-and-monitoring-of-neurological-29866603","doi":"10.1016/j.bj.2018.03.004","journal":"Biomedical journal","n_participants":null,"pmid":"29866603","source_url":"https://pubmed.ncbi.nlm.nih.gov/29866603/","study_design":null,"title":"Salivary biomarkers for the diagnosis and\u00a0monitoring of neurological diseases","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/proteomic-quantification-of-human-blood-brain-barrier-slc-and-abc-30735053","doi":"10.1021/acs.molpharmaceut.8b01189","journal":"Molecular pharmaceutics","n_participants":12,"pmid":"30735053","source_url":"https://pubmed.ncbi.nlm.nih.gov/30735053/","study_design":null,"title":"Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/vgf-as-a-biomarker-and-therapeutic-target-in-neurodegenerative-and-34778762","doi":"10.1093/braincomms/fcab261","journal":"Brain communications","n_participants":null,"pmid":"34778762","source_url":"https://pubmed.ncbi.nlm.nih.gov/34778762/","study_design":null,"title":"VGF as a biomarker and therapeutic target in neurodegenerative and psychiatric diseases","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/glial-degeneration-and-reactive-gliosis-in-alpha-synucleinopathies-16896905","doi":"10.1007/s00401-006-0119-z","journal":"Acta neuropathologica","n_participants":null,"pmid":"16896905","source_url":"https://pubmed.ncbi.nlm.nih.gov/16896905/","study_design":null,"title":"Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration","title_match":true,"year":2006},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/sup-18-sup-f-av-1451-in-parkinson-s-disease-with-and-without-dementia-29549278","doi":"10.1038/s41598-018-23041-x","journal":"Scientific reports","n_participants":18,"pmid":"29549278","source_url":"https://pubmed.ncbi.nlm.nih.gov/29549278/","study_design":null,"title":"18F-AV-1451 in Parkinson's Disease with and without dementia and in Dementia with Lewy Bodies","title_match":true,"year":2018},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/atypical-parkinsonian-syndromes-a-general-neurologist-s-perspective-28803444","doi":"10.1111/ene.13412","journal":"European journal of neurology","n_participants":null,"pmid":"28803444","source_url":"https://pubmed.ncbi.nlm.nih.gov/28803444/","study_design":null,"title":"Atypical parkinsonian syndromes: a general neurologist's perspective","title_match":false,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/regional-cortical-perfusion-on-arterial-spin-labeling-mri-in-dementia-30003031","doi":"10.1016/j.nicl.2018.06.020","journal":"NeuroImage. Clinical","n_participants":114,"pmid":"30003031","source_url":"https://pubmed.ncbi.nlm.nih.gov/30003031/","study_design":null,"title":"Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET","title_match":true,"year":2018},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/identification-and-in-vitro-characterization-of-c05-01-a-pbb3-32956648","doi":"10.1016/j.brainres.2020.147131","journal":"Brain research","n_participants":null,"pmid":"32956648","source_url":"https://pubmed.ncbi.nlm.nih.gov/32956648/","study_design":null,"title":"Identification and in vitro characterization of C05-01, a PBB3 derivative with improved affinity for alpha-synuclein","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/imaging-protein-misfolding-in-the-brain-using-sheet-ligands-30186106","doi":"10.3389/fnins.2018.00585","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"30186106","source_url":"https://pubmed.ncbi.nlm.nih.gov/30186106/","study_design":null,"title":"Imaging Protein Misfolding in the Brain Using \u03b2-Sheet Ligands","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/brain-injury-biomarkers-are-not-dependent-on-amyloid-in-normal-elderly-23424032","doi":"10.1002/ana.23816","journal":"Annals of neurology","n_participants":null,"pmid":"23424032","source_url":"https://pubmed.ncbi.nlm.nih.gov/23424032/","study_design":"cross-sectional","title":"Brain injury biomarkers are not dependent on \u03b2-amyloid in normal elderly","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/multimodality-imaging-characteristics-of-dementia-with-lewy-bodies-22018896","doi":"10.1016/j.neurobiolaging.2011.09.024","journal":"Neurobiology of aging","n_participants":21,"pmid":"22018896","source_url":"https://pubmed.ncbi.nlm.nih.gov/22018896/","study_design":null,"title":"Multimodality imaging characteristics of dementia with Lewy bodies","title_match":true,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-basis-of-cingulate-island-sign-25056580","doi":"10.1212/wnl.0000000000000734","journal":"Neurology","n_participants":39,"pmid":"25056580","source_url":"https://pubmed.ncbi.nlm.nih.gov/25056580/","study_design":null,"title":"Dementia with Lewy bodies: basis of cingulate island sign","title_match":true,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/brain-amyloid-and-cognition-in-lewy-body-diseases-22693110","doi":"10.1002/mds.25048","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"22693110","source_url":"https://pubmed.ncbi.nlm.nih.gov/22693110/","study_design":null,"title":"Brain amyloid and cognition in Lewy body diseases","title_match":true,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/early-microglial-activation-and-peripheral-inflammation-in-dementia-30403785","doi":"10.1093/brain/awy265","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"30403785","source_url":"https://pubmed.ncbi.nlm.nih.gov/30403785/","study_design":null,"title":"Early microglial activation and peripheral inflammation in dementia with Lewy bodies","title_match":true,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/development-of-positron-emission-tomography-amyloid-plaque-imaging-23026364","doi":"10.1053/j.semnuclmed.2012.07.001","journal":"Seminars in nuclear medicine","n_participants":null,"pmid":"23026364","source_url":"https://pubmed.ncbi.nlm.nih.gov/23026364/","study_design":null,"title":"Development of positron emission tomography \u03b2-amyloid plaque imaging agents","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/in-vitro-characterization-of-pittsburgh-compound-b-binding-to-lewy-17898208","doi":"10.1523/jneurosci.0630-07.2007","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"17898208","source_url":"https://pubmed.ncbi.nlm.nih.gov/17898208/","study_design":null,"title":"In vitro characterization of Pittsburgh compound-B binding to Lewy bodies","title_match":true,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-clinical-characteristics-of-dementia-with-lewy-bodies-and-a-25484925","doi":"10.1186/alzrt274","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"25484925","source_url":"https://pubmed.ncbi.nlm.nih.gov/25484925/","study_design":null,"title":"The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis","title_match":true,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-clinical-phenotype-of-idiopathic-rapid-eye-movement-sleep-26940460","doi":"10.5665/sleep.5332","journal":"Sleep","n_participants":null,"pmid":"26940460","source_url":"https://pubmed.ncbi.nlm.nih.gov/26940460/","study_design":null,"title":"The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-spectrum-of-parkinsonian-manifestations-associated-with-18852351","doi":"10.1001/archneur.65.10.1353","journal":"Archives of neurology","n_participants":null,"pmid":"18852351","source_url":"https://pubmed.ncbi.nlm.nih.gov/18852351/","study_design":null,"title":"The spectrum of parkinsonian manifestations associated with glucocerebrosidase mutations","title_match":false,"year":2008},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/neuropathology-of-autonomic-dysfunction-in-synucleinopathies-29297596","doi":"10.1002/mds.27186","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"29297596","source_url":"https://pubmed.ncbi.nlm.nih.gov/29297596/","study_design":null,"title":"Neuropathology of autonomic dysfunction in synucleinopathies","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/dopamine-transporter-imaging-deficit-predicts-early-transition-to-28833467","doi":"10.1002/ana.25026","journal":"Annals of neurology","n_participants":null,"pmid":"28833467","source_url":"https://pubmed.ncbi.nlm.nih.gov/28833467/","study_design":null,"title":"Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic rapid eye movement sleep behavior disorder","title_match":false,"year":2017},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/probable-rapid-eye-movement-sleep-behavior-disorder-increases-risk-22275251","doi":"10.1002/ana.22655","journal":"Annals of neurology","n_participants":null,"pmid":"22275251","source_url":"https://pubmed.ncbi.nlm.nih.gov/22275251/","study_design":"cohort study","title":"Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: a population-based study","title_match":false,"year":2012},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/phosphorylated-synuclein-in-the-retina-is-a-biomarker-of-parkinson-s-29737566","doi":"10.1002/mds.27392","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"29737566","source_url":"https://pubmed.ncbi.nlm.nih.gov/29737566/","study_design":null,"title":"Phosphorylated \u03b1-synuclein in the retina is a biomarker of Parkinson's disease pathology severity","title_match":true,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/beta-amyloid-phospho-tau-and-alpha-synuclein-deposits-similar-to-23714377","doi":"10.1111/bpa.12070","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"23714377","source_url":"https://pubmed.ncbi.nlm.nih.gov/23714377/","study_design":"case-control study","title":"Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients","title_match":true,"year":2014},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/rem-sleep-behavior-disorder-diagnosis-clinical-implications-and-29101940","doi":"10.1016/j.mayocp.2017.09.007","journal":"Mayo Clinic proceedings","n_participants":null,"pmid":"29101940","source_url":"https://pubmed.ncbi.nlm.nih.gov/29101940/","study_design":"longitudinal study","title":"REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/rem-sleep-behavior-disorder-and-neuropathology-in-parkinson-s-disease-26265105","doi":"10.1002/mds.26347","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"26265105","source_url":"https://pubmed.ncbi.nlm.nih.gov/26265105/","study_design":"longitudinal study","title":"REM sleep behavior disorder and neuropathology in Parkinson's disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/retinal-nerve-fiber-layer-thinning-in-dementia-associated-with-23271313","doi":"10.3233/jad-121975","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"23271313","source_url":"https://pubmed.ncbi.nlm.nih.gov/23271313/","study_design":null,"title":"Retinal nerve fiber layer thinning in dementia associated with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-small-molecule-alpha-synuclein-misfolding-inhibitor-npt200-11-30385782","doi":"10.1038/s41598-018-34490-9","journal":"Scientific reports","n_participants":null,"pmid":"30385782","source_url":"https://pubmed.ncbi.nlm.nih.gov/30385782/","study_design":"longitudinal study","title":"The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease","title_match":true,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/rapidly-progressive-autosomal-dominant-parkinsonism-and-dementia-with-1416801","doi":"10.1002/ana.410320303","journal":"Annals of neurology","n_participants":null,"pmid":"1416801","source_url":"https://pubmed.ncbi.nlm.nih.gov/1416801/","study_design":null,"title":"Rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration","title_match":false,"year":1992},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/rem-sleep-behavior-disorder-in-parkinson-s-disease-and-other-28513079","doi":"10.1002/mds.27018","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"28513079","source_url":"https://pubmed.ncbi.nlm.nih.gov/28513079/","study_design":null,"title":"REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/phosphorylated-synuclein-immunoreactive-retinal-neuronal-elements-in-24785101","doi":"10.1016/j.neulet.2014.04.027","journal":"Neuroscience letters","n_participants":null,"pmid":"24785101","source_url":"https://pubmed.ncbi.nlm.nih.gov/24785101/","study_design":null,"title":"Phosphorylated \u03b1-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects","title_match":true,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-spectrum-of-cognitive-impairment-in-lewy-body-diseases-24757110","doi":"10.1002/mds.25866","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"24757110","source_url":"https://pubmed.ncbi.nlm.nih.gov/24757110/","study_design":null,"title":"The spectrum of cognitive impairment in Lewy body diseases","title_match":true,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/validation-of-the-neuropathologic-criteria-of-the-third-consortium-18596548","doi":"10.1097/nen.0b013e31817d7a1d","journal":"Journal of neuropathology and experimental neurology","n_participants":76,"pmid":"18596548","source_url":"https://pubmed.ncbi.nlm.nih.gov/18596548/","study_design":null,"title":"Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases","title_match":true,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/testing-an-aetiological-model-of-visual-hallucinations-in-parkinson-s-21921019","doi":"10.1093/brain/awr225","journal":"Brain : a journal of neurology","n_participants":94,"pmid":"21921019","source_url":"https://pubmed.ncbi.nlm.nih.gov/21921019/","study_design":null,"title":"Testing an aetiological model of visual hallucinations in Parkinson's disease","title_match":false,"year":2011},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/validation-of-the-mds-research-criteria-for-prodromal-parkinson-s-28429825","doi":"10.1002/mds.26989","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":121,"pmid":"28429825","source_url":"https://pubmed.ncbi.nlm.nih.gov/28429825/","study_design":"cohort study","title":"Validation of the MDS research criteria for prodromal Parkinson's disease: Longitudinal assessment in a REM sleep behavior disorder (RBD) cohort","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/oculo-visual-dysfunction-in-parkinson-s-disease-26599301","doi":"10.3233/jpd-150686","journal":"Journal of Parkinson's disease","n_participants":null,"pmid":"26599301","source_url":"https://pubmed.ncbi.nlm.nih.gov/26599301/","study_design":null,"title":"Oculo-Visual Dysfunction in Parkinson's Disease","title_match":false,"year":2015},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/frequency-and-correlates-of-caregiver-reported-sleep-disturbances-in-20398116","doi":"10.1111/j.1532-5415.2010.02733.x","journal":"Journal of the American Geriatrics Society","n_participants":420,"pmid":"20398116","source_url":"https://pubmed.ncbi.nlm.nih.gov/20398116/","study_design":"cross-sectional","title":"Frequency and correlates of caregiver-reported sleep disturbances in a sample of persons with early dementia","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-impact-of-co-pathologies-and-implications-36239924","doi":"10.1002/alz.12814","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36239924","source_url":"https://pubmed.ncbi.nlm.nih.gov/36239924/","study_design":"cross-sectional","title":"Dementia with Lewy bodies: Impact of co-pathologies and implications for clinical trial design","title_match":true,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/rem-sleep-behavior-disorder-and-rem-sleep-without-atonia-as-an-early-22328094","doi":"10.1007/s11910-012-0253-z","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"22328094","source_url":"https://pubmed.ncbi.nlm.nih.gov/22328094/","study_design":null,"title":"REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/electroencephalographic-slowing-heralds-mild-cognitive-impairment-in-20462792","doi":"10.1016/j.sleep.2010.03.006","journal":"Sleep medicine","n_participants":null,"pmid":"20462792","source_url":"https://pubmed.ncbi.nlm.nih.gov/20462792/","study_design":null,"title":"Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/aceruloplasminemia-an-iron-metabolic-disorder-14719552","doi":"10.1046/j.1440-1789.2003.00521.x","journal":"Neuropathology : official journal of the Japanese Society of Neuropathology","n_participants":null,"pmid":"14719552","source_url":"https://pubmed.ncbi.nlm.nih.gov/14719552/","study_design":null,"title":"Aceruloplasminemia, an iron metabolic disorder","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/glucocerebrosidase-deficiency-accelerates-the-accumulation-of-26362253","doi":"10.1093/hmg/ddv372","journal":"Human molecular genetics","n_participants":null,"pmid":"26362253","source_url":"https://pubmed.ncbi.nlm.nih.gov/26362253/","study_design":null,"title":"Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant \u03b1-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease","title_match":true,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/when-do-synucleinopathies-start-an-epidemiological-timeline-a-review-29459985","doi":"10.1001/jamaneurol.2017.4243","journal":"JAMA neurology","n_participants":null,"pmid":"29459985","source_url":"https://pubmed.ncbi.nlm.nih.gov/29459985/","study_design":null,"title":"When Do \u03b1-Synucleinopathies Start? An Epidemiological Timeline: A Review","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/rapid-eye-movement-sleep-behavior-disorder-and-subtypes-in-autopsy-22038951","doi":"10.1002/mds.24003","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":71,"pmid":"22038951","source_url":"https://pubmed.ncbi.nlm.nih.gov/22038951/","study_design":null,"title":"Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies","title_match":true,"year":2012},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/meta-analysis-of-123i-mibg-cardiac-scintigraphy-for-the-diagnosis-of-21480373","doi":"10.1002/mds.23659","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":2680,"pmid":"21480373","source_url":"https://pubmed.ncbi.nlm.nih.gov/21480373/","study_design":"meta-analysis","title":"Meta-analysis of 123I-MIBG cardiac scintigraphy for the diagnosis of Lewy body-related disorders","title_match":true,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/conformational-diseases-looking-into-the-eyes-19808079","doi":"10.1016/j.brainresbull.2009.09.015","journal":"Brain research bulletin","n_participants":null,"pmid":"19808079","source_url":"https://pubmed.ncbi.nlm.nih.gov/19808079/","study_design":null,"title":"Conformational diseases: looking into the eyes","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/uncoupling-neuronal-death-and-dysfunction-in-drosophila-models-of-27338814","doi":"10.1186/s40478-016-0333-4","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"27338814","source_url":"https://pubmed.ncbi.nlm.nih.gov/27338814/","study_design":null,"title":"Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/diagnostic-criteria-for-dementia-with-lewy-bodies-updates-and-future-31694357","doi":"10.14802/jmd.19052","journal":"Journal of movement disorders","n_participants":null,"pmid":"31694357","source_url":"https://pubmed.ncbi.nlm.nih.gov/31694357/","study_design":null,"title":"Diagnostic Criteria for Dementia with Lewy Bodies: Updates and Future Directions","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/visual-hallucinations-in-pd-and-lewy-body-dementias-old-and-new-23242366","doi":"10.3233/ben-129022","journal":"Behavioural neurology","n_participants":null,"pmid":"23242366","source_url":"https://pubmed.ncbi.nlm.nih.gov/23242366/","study_design":null,"title":"Visual hallucinations in PD and Lewy body dementias: old and new hypotheses","title_match":true,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuropathological-analysis-of-brainstem-cholinergic-and-21696423","doi":"10.1111/j.1365-2990.2011.01203.x","journal":"Neuropathology and applied neurobiology","n_participants":null,"pmid":"21696423","source_url":"https://pubmed.ncbi.nlm.nih.gov/21696423/","study_design":null,"title":"Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/enhanced-atpase-activities-as-a-primary-defect-of-mutant-valosin-20604808","doi":"10.1111/j.1365-2443.2010.01428.x","journal":"Genes to cells : devoted to molecular & cellular mechanisms","n_participants":null,"pmid":"20604808","source_url":"https://pubmed.ncbi.nlm.nih.gov/20604808/","study_design":null,"title":"Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/olfactory-deficit-in-idiopathic-rapid-eye-movements-sleep-behavior-17027774","doi":"10.1016/j.brainresbull.2006.07.008","journal":"Brain research bulletin","n_participants":null,"pmid":"17027774","source_url":"https://pubmed.ncbi.nlm.nih.gov/17027774/","study_design":null,"title":"Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder","title_match":false,"year":2006},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/rapid-eye-movement-sleep-behavior-disorder-and-neurodegenerative-32257544","doi":"10.14336/ad.2019.0324","journal":"Aging and disease","n_participants":null,"pmid":"32257544","source_url":"https://pubmed.ncbi.nlm.nih.gov/32257544/","study_design":null,"title":"Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-and-cognitive-profile-in-mild-cognitive-29362011","doi":"10.1017/s0033291717003956","journal":"Psychological medicine","n_participants":41,"pmid":"29362011","source_url":"https://pubmed.ncbi.nlm.nih.gov/29362011/","study_design":null,"title":"Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies","title_match":true,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/synucleins-in-ocular-tissues-11433431","doi":"10.1002/jnr.1129","journal":"Journal of neuroscience research","n_participants":null,"pmid":"11433431","source_url":"https://pubmed.ncbi.nlm.nih.gov/11433431/","study_design":null,"title":"Synucleins in ocular tissues","title_match":false,"year":2001},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/pharmacological-management-of-dementia-with-lewy-bodies-30680679","doi":"10.1007/s40266-018-00636-7","journal":"Drugs & aging","n_participants":null,"pmid":"30680679","source_url":"https://pubmed.ncbi.nlm.nih.gov/30680679/","study_design":"clinical trial","title":"Pharmacological Management of Dementia with Lewy Bodies","title_match":true,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-and-alpha-synuclein-translation-19166904","doi":"10.1016/j.bbagen.2008.12.001","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"19166904","source_url":"https://pubmed.ncbi.nlm.nih.gov/19166904/","study_design":null,"title":"Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases","title_match":false,"year":2009},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/o-glcnac-modification-of-small-heat-shock-proteins-enhances-their-33723378","doi":"10.1038/s41557-021-00648-8","journal":"Nature chemistry","n_participants":null,"pmid":"33723378","source_url":"https://pubmed.ncbi.nlm.nih.gov/33723378/","study_design":null,"title":"O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/pathological-roles-of-synuclein-in-neurological-disorders-22014436","doi":"10.1016/s1474-4422(11)70213-7","journal":"The Lancet. Neurology","n_participants":null,"pmid":"22014436","source_url":"https://pubmed.ncbi.nlm.nih.gov/22014436/","study_design":null,"title":"Pathological roles of \u03b1-synuclein in neurological disorders","title_match":true,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-oligomers-as-a-template-for-secondary-amyloidosis-in-25134727","doi":"10.1016/j.nbd.2014.08.008","journal":"Neurobiology of disease","n_participants":null,"pmid":"25134727","source_url":"https://pubmed.ncbi.nlm.nih.gov/25134727/","study_design":null,"title":"Amyloid-\u03b2 oligomers as a template for secondary amyloidosis in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/polymorphism-of-alpha-synuclein-amyloid-fibrils-depends-on-ionic-34830264","doi":"10.3390/ijms222212382","journal":"International journal of molecular sciences","n_participants":null,"pmid":"34830264","source_url":"https://pubmed.ncbi.nlm.nih.gov/34830264/","study_design":null,"title":"Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-combination-therapies-and-clinical-trials-for-38937382","doi":"10.1007/s40263-024-01103-1","journal":"CNS drugs","n_participants":null,"pmid":"38937382","source_url":"https://pubmed.ncbi.nlm.nih.gov/38937382/","study_design":"clinical trial","title":"Alzheimer's Disease: Combination Therapies and Clinical Trials for Combination Therapy Development","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-combined-effect-of-amyloid-and-tau-biomarkers-on-brain-atrophy-in-32674011","doi":"10.1016/j.nicl.2020.102333","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"32674011","source_url":"https://pubmed.ncbi.nlm.nih.gov/32674011/","study_design":null,"title":"The combined effect of amyloid-\u03b2 and tau biomarkers on brain atrophy in dementia with Lewy bodies","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/generic-inhibition-of-amyloidogenic-proteins-by-two-naphthoquinone-22488522","doi":"10.1002/prot.24080","journal":"Proteins","n_participants":null,"pmid":"22488522","source_url":"https://pubmed.ncbi.nlm.nih.gov/22488522/","study_design":null,"title":"Generic inhibition of amyloidogenic proteins by two naphthoquinone-tryptophan hybrid molecules","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-and-synuclein-immunotherapy-from-experimental-studies-to-34539340","doi":"10.3389/fnins.2021.733857","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"34539340","source_url":"https://pubmed.ncbi.nlm.nih.gov/34539340/","study_design":null,"title":"Amyloid-\u03b2 and \u03b1-Synuclein Immunotherapy: From Experimental Studies to Clinical Trials","title_match":true,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/imaging-amyloid-in-parkinson-s-disease-dementia-and-dementia-with-19877240","doi":"10.1002/mds.22581","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"19877240","source_url":"https://pubmed.ncbi.nlm.nih.gov/19877240/","study_design":null,"title":"Imaging amyloid in Parkinson's disease dementia and dementia with Lewy bodies with positron emission tomography","title_match":true,"year":2009},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/general-aggregation-induced-emission-probes-for-amyloid-inhibitors-32584021","doi":"10.1021/acsami.0c07745","journal":"ACS applied materials & interfaces","n_participants":null,"pmid":"32584021","source_url":"https://pubmed.ncbi.nlm.nih.gov/32584021/","study_design":null,"title":"General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid \u03b2-Protein and \u03b1-Synuclein","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/toward-the-discovery-of-effective-polycyclic-inhibitors-of-alpha-21795682","doi":"10.1074/jbc.m111.242958","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"21795682","source_url":"https://pubmed.ncbi.nlm.nih.gov/21795682/","study_design":null,"title":"Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly","title_match":true,"year":2011},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/microtubule-associated-protein-tau-heparan-sulphate-and-alpha-10378377","doi":"10.1007/s004010051034","journal":"Acta neuropathologica","n_participants":null,"pmid":"10378377","source_url":"https://pubmed.ncbi.nlm.nih.gov/10378377/","study_design":null,"title":"Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia","title_match":true,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/phosphorylated-protein-kinases-associated-with-neuronal-and-glial-tau-12580546","doi":"10.1111/j.1750-3639.2003.tb00007.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"12580546","source_url":"https://pubmed.ncbi.nlm.nih.gov/12580546/","study_design":null,"title":"Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease","title_match":false,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-role-of-antibodies-and-their-receptors-in-protection-against-31214163","doi":"10.3389/fimmu.2019.01139","journal":"Frontiers in immunology","n_participants":null,"pmid":"31214163","source_url":"https://pubmed.ncbi.nlm.nih.gov/31214163/","study_design":null,"title":"The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/pathological-tau-deposition-in-motor-neurone-disease-and-27036121","doi":"10.1186/s40478-016-0301-z","journal":"Acta neuropathologica communications","n_participants":41,"pmid":"27036121","source_url":"https://pubmed.ncbi.nlm.nih.gov/27036121/","study_design":"clinical trial","title":"Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/characterization-of-tau-pathologies-in-gray-and-white-matter-of-guam-16609851","doi":"10.1007/s00401-006-0053-0","journal":"Acta neuropathologica","n_participants":null,"pmid":"16609851","source_url":"https://pubmed.ncbi.nlm.nih.gov/16609851/","study_design":null,"title":"Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/clinical-and-neuropathological-aspects-of-diffuse-lewy-body-disease-8420171","doi":null,"journal":"Advances in neurology","n_participants":null,"pmid":"8420171","source_url":"https://pubmed.ncbi.nlm.nih.gov/8420171/","study_design":null,"title":"Clinical and neuropathological aspects of diffuse Lewy body disease in the elderly","title_match":true,"year":1993},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/finding-the-falsification-threshold-of-the-toxic-proteinopathy-36796939","doi":"10.1016/b978-0-323-85538-9.00008-0","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"36796939","source_url":"https://pubmed.ncbi.nlm.nih.gov/36796939/","study_design":null,"title":"Finding the falsification threshold of the toxic proteinopathy hypothesis in neurodegeneration","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/comorbidities-in-early-onset-sporadic-versus-presenilin-1-mutation-39656832","doi":"10.1093/jnen/nlae122","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"39656832","source_url":"https://pubmed.ncbi.nlm.nih.gov/39656832/","study_design":null,"title":"Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-frequency-of-lewy-bodies-in-a-consecutive-autopsy-series-9707335","doi":null,"journal":"Clinical neuropathology","n_participants":284,"pmid":"9707335","source_url":"https://pubmed.ncbi.nlm.nih.gov/9707335/","study_design":null,"title":"The frequency of Lewy bodies in a consecutive autopsy series","title_match":true,"year":1998},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/susceptibility-magnetic-resonance-imaging-correlates-with-glial-36598274","doi":"10.1002/mds.29311","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":27,"pmid":"36598274","source_url":"https://pubmed.ncbi.nlm.nih.gov/36598274/","study_design":null,"title":"Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/viral-like-tlr3-induction-of-cytokine-networks-and-synuclein-are-37704739","doi":"10.1038/s41598-023-41240-z","journal":"Scientific reports","n_participants":null,"pmid":"37704739","source_url":"https://pubmed.ncbi.nlm.nih.gov/37704739/","study_design":null,"title":"Viral-like TLR3 induction of cytokine networks and \u03b1-synuclein are reduced by complement C3 blockade in mouse brain","title_match":true,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/novel-systemic-delivery-of-a-peptide-conjugated-antisense-37690676","doi":"10.1016/j.nbd.2023.106285","journal":"Neurobiology of disease","n_participants":null,"pmid":"37690676","source_url":"https://pubmed.ncbi.nlm.nih.gov/37690676/","study_design":null,"title":"Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce \u03b1-synuclein in a mouse model of Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/familial-motor-neurone-disease-with-dementia-phenotypic-variation-and-14617708","doi":"10.1136/jnnp.74.11.1516","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"14617708","source_url":"https://pubmed.ncbi.nlm.nih.gov/14617708/","study_design":null,"title":"Familial motor neurone disease with dementia: phenotypic variation and cerebellar pathology","title_match":false,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/strategies-of-positron-emission-tomography-pet-tracer-development-for-39678127","doi":"10.1039/d4md00576g","journal":"RSC medicinal chemistry","n_participants":null,"pmid":"39678127","source_url":"https://pubmed.ncbi.nlm.nih.gov/39678127/","study_design":null,"title":"Strategies of positron emission tomography (PET) tracer development for imaging of tau and \u03b1-synuclein in neurodegenerative disorders","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-splice-switching-antisense-oligonucleotide-targeting-app-reduces-40556661","doi":"10.1002/trc2.70117","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"40556661","source_url":"https://pubmed.ncbi.nlm.nih.gov/40556661/","study_design":null,"title":"A splice-switching antisense oligonucleotide targeting APP reduces accumulation of \u03b1-synuclein in a mouse model of Parkinson's disease","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/autoantibody-profiles-in-alzheimer-s-parkinson-s-and-dementia-with-39627772","doi":"10.1186/s12974-024-03293-3","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"39627772","source_url":"https://pubmed.ncbi.nlm.nih.gov/39627772/","study_design":null,"title":"Autoantibody profiles in Alzheimer\u00b4s, Parkinson\u00b4s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns","title_match":true,"year":2024}]}
