{"data_date":"2026-11-08","library_size":29380,"matched_against":"each record's title and abstract (summary field), case-insensitive","n":2309,"page":"https://alzhub.org/answers/is-alzheimers-hereditary","query":"title or abstract mentions \"familial\", \"family history\", \"autosomal dominant\", \"PSEN1/PSEN2\", \"presenilin\", \"inherited/inheritance/heritable\", \"heritability\", \"APP mutation\", \"genetic risk\" or \"polygenic\"","studies":[{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/pittsburgh-plasma-p-tau217-classification-accuracies-for-autosomal-e4bc0f72","doi":null,"journal":"Alzheimer's & Dementia","n_participants":363,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12263344/","study_design":"cross-sectional","title":"Pittsburgh plasma p-tau217: Classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the community","title_match":true,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/apoe4-homozygosity-represents-a-distinct-genetic-form-of-alzheimer-s-3b742ebe","doi":null,"journal":"Nature Medicine","n_participants":null,"pmid":null,"source_url":"https://www.nature.com/articles/s41591-024-02931-w","study_design":"cohort","title":"APOE4 homozygosity represents a distinct genetic form of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/apoe-and-trem2-regulate-amyloid-responsive-microglia-in-alzheimer-s-32840654","doi":"10.1007/s00401-020-02200-3","journal":"Acta neuropathologica","n_participants":null,"pmid":"32840654","source_url":"https://pubmed.ncbi.nlm.nih.gov/32840654/","study_design":null,"title":"APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/new-insights-into-the-genetic-etiology-of-alzheimer-s-disease-and-afeff1fb","doi":null,"journal":"Nature Genetics","n_participants":788989,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9005347/","study_design":"meta-analysis","title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","title_match":false,"year":2022},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/consensus-meta-analysis-of-genome-wide-association-studies-for-6dc8c8dc","doi":null,"journal":"Nature Genetics","n_participants":978514,"pmid":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/42237039/","study_design":"meta-analysis","title":"Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/genetic-risk-for-alzheimer-disease-is-distinct-from-genetic-risk-for-0e415d77","doi":null,"journal":"Annals of Neurology","n_participants":770,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6771864/","study_design":"case-control","title":"Genetic risk for Alzheimer disease is distinct from genetic risk for amyloid deposition","title_match":true,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-dynamics-predicts-neurodegeneration-and-clinical-9106bc9f","doi":null,"journal":"Nature Medicine","n_participants":405,"pmid":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/30664784/","study_design":"cohort","title":"Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/impact-of-learning-apoe-genotype-on-cognitively-unimpaired-adults-a-41319675","doi":"10.1016/j.lanhl.2025.100778","journal":"The Lancet Healthy Longevity","n_participants":9496,"pmid":"41319675","source_url":"https://pubmed.ncbi.nlm.nih.gov/41319675/","study_design":"cohort","title":"Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/genetic-risk-for-alzheimer-disease-midlife-hypertension-and-dementia-42385118","doi":"10.1212/WNL.0000000000218280","journal":"Neurology","n_participants":11597,"pmid":"42385118","source_url":"https://pubmed.ncbi.nlm.nih.gov/42385118/","study_design":"cohort","title":"Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study","title_match":true,"year":2026},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/prioritizing-modifiable-risk-factors-for-dementia-prevention-across-41085200","doi":"10.1002/ana.78060","journal":"Annals of Neurology","n_participants":182473,"pmid":"41085200","source_url":"https://pubmed.ncbi.nlm.nih.gov/41085200/","study_design":"cohort","title":"Prioritizing Modifiable Risk Factors for Dementia Prevention across the Spectrum of Genetic Susceptibility: A Prospective Cohort Study","title_match":false,"year":2025},{"alzhub_score":87,"alzhub_url":"https://alzhub.org/study/trial-of-the-mind-diet-for-prevention-of-cognitive-decline-in-older-37466280","doi":"10.1056/NEJMoa2302368","journal":"New England Journal of Medicine","n_participants":604,"pmid":"37466280","source_url":"https://pubmed.ncbi.nlm.nih.gov/37466280/","study_design":"RCT","title":"Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons","title_match":false,"year":2023},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-adherence-is-associated-with-lower-dementia-risk-36915130","doi":"10.1186/s12916-023-02772-3","journal":"BMC Medicine","n_participants":60298,"pmid":"36915130","source_url":"https://pubmed.ncbi.nlm.nih.gov/36915130/","study_design":"cohort","title":"Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/flavonoid-rich-foods-dementia-risk-and-interactions-with-genetic-risk-39292460","doi":"10.1001/jamanetworkopen.2024.34136","journal":"JAMA Network Open","n_participants":121986,"pmid":"39292460","source_url":"https://pubmed.ncbi.nlm.nih.gov/39292460/","study_design":"cohort","title":"Flavonoid-Rich Foods, Dementia Risk, and Interactions With Genetic Risk, Hypertension, and Depression","title_match":true,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/educational-attainment-and-dementia-mediation-by-mid-life-vascular-36966451","doi":"10.1002/ana.26647","journal":"Annals of Neurology","n_participants":13368,"pmid":"36966451","source_url":"https://pubmed.ncbi.nlm.nih.gov/36966451/","study_design":"cohort","title":"Educational Attainment and Dementia: Mediation by Mid-Life Vascular Risk Factors","title_match":false,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/association-between-slow-wave-sleep-loss-and-incident-dementia-37902739","doi":"10.1001/jamaneurol.2023.3889","journal":"JAMA Neurology","n_participants":346,"pmid":"37902739","source_url":"https://pubmed.ncbi.nlm.nih.gov/37902739/","study_design":"cohort","title":"Association Between Slow-Wave Sleep Loss and Incident Dementia","title_match":false,"year":2023},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/visual-impairment-eye-conditions-and-diagnoses-of-neurodegeneration-39078629","doi":"10.1001/jamanetworkopen.2024.24539","journal":"JAMA Network Open","n_participants":304953,"pmid":"39078629","source_url":"https://pubmed.ncbi.nlm.nih.gov/39078629/","study_design":"cohort","title":"Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-concentrations-apoe-genotype-and-timing-42716078","doi":"10.1016/S1474-4422(26)00313-3","journal":"The Lancet. Neurology","n_participants":8582,"pmid":"42716078","source_url":"https://pubmed.ncbi.nlm.nih.gov/42716078/","study_design":"cohort","title":"Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies","title_match":false,"year":2026},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/alzheimer-and-cardiovascular-genetic-scores-and-cognition-the-finger-40747850","doi":"10.1093/brain/awaf277","journal":"Brain : a journal of neurology","n_participants":1177,"pmid":"40747850","source_url":"https://pubmed.ncbi.nlm.nih.gov/40747850/","study_design":"RCT","title":"Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial","title_match":false,"year":2026},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/association-of-african-ancestry-specific-apoe-missense-variant-r145c-36809323","doi":"10.1001/jama.2023.0268","journal":"JAMA","n_participants":31929,"pmid":"36809323","source_url":"https://pubmed.ncbi.nlm.nih.gov/36809323/","study_design":"case-control","title":"Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease","title_match":false,"year":2023},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/apoe3-christchurch-heterozygosity-and-autosomal-dominant-alzheimer-s-38899694","doi":"10.1056/NEJMoa2308583","journal":"New England Journal of Medicine","n_participants":1077,"pmid":"38899694","source_url":"https://pubmed.ncbi.nlm.nih.gov/38899694/","study_design":"cohort","title":"APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease","title_match":true,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/resilience-to-autosomal-dominant-alzheimer-s-disease-in-a-reelin-37188781","doi":"10.1038/s41591-023-02318-3","journal":"Nature Medicine","n_participants":null,"pmid":"37188781","source_url":"https://pubmed.ncbi.nlm.nih.gov/37188781/","study_design":null,"title":"Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/admixture-mapping-identifies-novel-alzheimer-s-disease-risk-regions-36539198","doi":"10.1002/alz.12865","journal":"Alzheimer's & Dementia","n_participants":10271,"pmid":"36539198","source_url":"https://pubmed.ncbi.nlm.nih.gov/36539198/","study_design":"case-control","title":"Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/validation-of-newly-derived-polygenic-risk-scores-for-dementia-in-a-37177856","doi":"10.1002/alz.13113","journal":"Alzheimer's & Dementia","n_participants":12031,"pmid":"37177856","source_url":"https://pubmed.ncbi.nlm.nih.gov/37177856/","study_design":"cohort","title":"Validation of newly derived polygenic risk scores for dementia in a prospective study of older individuals","title_match":true,"year":2023},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/polygenic-score-integrating-neurodegenerative-and-vascular-risk-40042447","doi":"10.1002/alz.70014","journal":"Alzheimer's & Dementia","n_participants":241935,"pmid":"40042447","source_url":"https://pubmed.ncbi.nlm.nih.gov/40042447/","study_design":"cohort","title":"Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/aavrh-10-delivery-of-novel-apoe2-christchurch-variant-suppresses-39511891","doi":"10.1016/j.ymthe.2024.11.003","journal":"Molecular Therapy","n_participants":null,"pmid":"39511891","source_url":"https://pubmed.ncbi.nlm.nih.gov/39511891/","study_design":null,"title":"AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer's disease mice","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/app-antisense-oligonucleotides-reduce-amyloid-aggregation-and-rescue-38527856","doi":"10.1093/brain/awae092","journal":"Brain","n_participants":null,"pmid":"38527856","source_url":"https://pubmed.ncbi.nlm.nih.gov/38527856/","study_design":null,"title":"APP antisense oligonucleotides reduce amyloid-\u03b2 aggregation and rescue endolysosomal dysfunction in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/immune-checkpoint-tim-3-regulates-microglia-and-alzheimer-s-disease-40205047","doi":"10.1038/s41586-025-08852-z","journal":"Nature","n_participants":null,"pmid":"40205047","source_url":"https://pubmed.ncbi.nlm.nih.gov/40205047/","study_design":null,"title":"Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/apoe4-lowers-the-ptau217-threshold-for-tau-aggregation-and-spread-in-41410687","doi":"10.1093/brain/awaf463","journal":"Brain","n_participants":401,"pmid":"41410687","source_url":"https://pubmed.ncbi.nlm.nih.gov/41410687/","study_design":"cohort","title":"ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-stratified-genome-wide-association-analyses-provide-insights-42736378","doi":"10.1038/s41588-026-02713-9","journal":"Nature genetics","n_participants":null,"pmid":"42736378","source_url":"https://pubmed.ncbi.nlm.nih.gov/42736378/","study_design":"case-control","title":"APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease","title_match":false,"year":2026},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/a-multiancestry-polygenic-risk-score-for-alzheimer-s-disease-is-42661068","doi":"10.1038/s41588-026-02722-8","journal":"Nature genetics","n_participants":null,"pmid":"42661068","source_url":"https://pubmed.ncbi.nlm.nih.gov/42661068/","study_design":"cohort","title":"A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations","title_match":true,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/a-common-19-bp-apoe-enhancer-deletion-is-protective-against-alzheimer-41629326","doi":"10.1038/s41467-026-68808-3","journal":"Nature Communications","n_participants":null,"pmid":"41629326","source_url":"https://pubmed.ncbi.nlm.nih.gov/41629326/","study_design":"case-control","title":"A common 19\u2009bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/transferability-of-european-derived-alzheimer-s-disease-polygenic-40533518","doi":"10.1038/s41588-025-02227-w","journal":"Nature genetics","n_participants":null,"pmid":"40533518","source_url":"https://pubmed.ncbi.nlm.nih.gov/40533518/","study_design":"cohort","title":"Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations","title_match":true,"year":2025},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/discriminative-accuracy-of-plasma-phospho-tau217-for-alzheimer-32722745","doi":"10.1001/jama.2020.12134","journal":"JAMA","n_participants":301,"pmid":"32722745","source_url":"https://pubmed.ncbi.nlm.nih.gov/32722745/","study_design":"cross-sectional","title":"Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders","title_match":false,"year":2020},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-dynamics-predicts-neurodegeneration-and-clinical-30664784","doi":"10.1038/s41591-018-0304-3","journal":"Nature medicine","n_participants":187,"pmid":"30664784","source_url":"https://pubmed.ncbi.nlm.nih.gov/30664784/","study_design":"cross-sectional","title":"Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-factors-with-elevated-amyloid-burden-in-clinically-32250387","doi":"10.1001/jamaneurol.2020.0387","journal":"JAMA neurology","n_participants":4486,"pmid":"32250387","source_url":"https://pubmed.ncbi.nlm.nih.gov/32250387/","study_design":"cross-sectional","title":"Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals","title_match":false,"year":2020},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-in-familial-alzheimer-disease-a-marker-of-29070659","doi":"10.1212/wnl.0000000000004667","journal":"Neurology","n_participants":48,"pmid":"29070659","source_url":"https://pubmed.ncbi.nlm.nih.gov/29070659/","study_design":"cross-sectional","title":"Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration","title_match":true,"year":2017},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/electroacupuncture-ameliorates-beta-amyloid-pathology-and-cognitive-33622188","doi":"10.1080/15548627.2021.1886720","journal":"Autophagy","n_participants":null,"pmid":"33622188","source_url":"https://pubmed.ncbi.nlm.nih.gov/33622188/","study_design":null,"title":"Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-in-the-presenilin-1-e280a-autosomal-32470423","doi":"10.1016/s1474-4422(20)30137-x","journal":"The Lancet. Neurology","n_participants":null,"pmid":"32470423","source_url":"https://pubmed.ncbi.nlm.nih.gov/32470423/","study_design":"cohort study","title":"Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study","title_match":true,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/selective-reduction-of-astrocyte-apoe3-and-apoe4-strongly-reduces-a-35109920","doi":"10.1186/s13024-022-00516-0","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"35109920","source_url":"https://pubmed.ncbi.nlm.nih.gov/35109920/","study_design":null,"title":"Selective reduction of astrocyte apoE3 and apoE4 strongly reduces A\u03b2 accumulation and plaque-related pathology in a mouse model of amyloidosis","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/brain-imaging-and-blood-biomarker-abnormalities-in-children-with-26121081","doi":"10.1001/jamaneurol.2015.1099","journal":"JAMA neurology","n_participants":null,"pmid":"26121081","source_url":"https://pubmed.ncbi.nlm.nih.gov/26121081/","study_design":"cross-sectional","title":"Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study","title_match":true,"year":2015},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/timing-of-biomarker-changes-in-sporadic-alzheimer-s-disease-in-38400792","doi":"10.1002/ana.26891","journal":"Annals of neurology","n_participants":118,"pmid":"38400792","source_url":"https://pubmed.ncbi.nlm.nih.gov/38400792/","study_design":"cross-sectional","title":"Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset","title_match":false,"year":2024},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/enhanced-oxidative-stress-is-an-early-event-during-development-of-18539391","doi":"10.1016/j.neulet.2008.05.050","journal":"Neuroscience letters","n_participants":null,"pmid":"18539391","source_url":"https://pubmed.ncbi.nlm.nih.gov/18539391/","study_design":null,"title":"Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice","title_match":true,"year":2008},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-bdnf-lt-sub-gt-val66met-lt-sub-gt-snp-modulates-the-association-30899092","doi":"10.1038/s41380-019-0404-6","journal":"Molecular psychiatry","n_participants":149,"pmid":"30899092","source_url":"https://pubmed.ncbi.nlm.nih.gov/30899092/","study_design":null,"title":"The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/comparison-of-csf-biomarkers-in-down-syndrome-and-autosomal-dominant-34302786","doi":"10.1016/s1474-4422(21)00139-3","journal":"The Lancet. Neurology","n_participants":41,"pmid":"34302786","source_url":"https://pubmed.ncbi.nlm.nih.gov/34302786/","study_design":"cross-sectional","title":"Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study","title_match":true,"year":2021},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/comparison-of-amyloid-burden-in-individuals-with-down-syndrome-versus-36517172","doi":"10.1016/s1474-4422(22)00408-2","journal":"The Lancet. Neurology","n_participants":216,"pmid":"36517172","source_url":"https://pubmed.ncbi.nlm.nih.gov/36517172/","study_design":"cross-sectional","title":"Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study","title_match":true,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/comprehension-of-an-elevated-amyloid-positron-emission-tomography-29059270","doi":"10.1001/jamaneurol.2017.2954","journal":"JAMA neurology","n_participants":80,"pmid":"29059270","source_url":"https://pubmed.ncbi.nlm.nih.gov/29059270/","study_design":null,"title":"Comprehension of an Elevated Amyloid Positron Emission Tomography Biomarker Result by Cognitively Normal Older Adults","title_match":false,"year":2018},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cotton-wool-plaques-in-non-familial-late-onset-alzheimer-disease-11706935","doi":"10.1093/jnen/60.11.1051","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"11706935","source_url":"https://pubmed.ncbi.nlm.nih.gov/11706935/","study_design":null,"title":"Cotton wool plaques in non-familial late-onset Alzheimer disease","title_match":true,"year":2001},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-and-sporadic-late-onset-alzheimer-s-disease-share-35580594","doi":"10.1093/brain/awac181","journal":"Brain : a journal of neurology","n_participants":559,"pmid":"35580594","source_url":"https://pubmed.ncbi.nlm.nih.gov/35580594/","study_design":null,"title":"Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/roles-of-vascular-and-metabolic-components-in-cognitive-dysfunction-24204343","doi":"10.3389/fnagi.2013.00064","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"24204343","source_url":"https://pubmed.ncbi.nlm.nih.gov/24204343/","study_design":null,"title":"Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factors","title_match":true,"year":2013},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/selective-deletion-of-apolipoprotein-e-in-astrocytes-ameliorates-the-28366226","doi":"10.1016/j.neurobiolaging.2017.03.002","journal":"Neurobiology of aging","n_participants":null,"pmid":"28366226","source_url":"https://pubmed.ncbi.nlm.nih.gov/28366226/","study_design":null,"title":"Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-\u03b2/Smad2/STAT3 signaling","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/lysosomal-tpcn-two-pore-segment-channel-inhibition-ameliorates-beta-34313551","doi":"10.1080/15548627.2021.1945220","journal":"Autophagy","n_participants":null,"pmid":"34313551","source_url":"https://pubmed.ncbi.nlm.nih.gov/34313551/","study_design":null,"title":"Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease","title_match":false,"year":2022},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/comparative-neurofilament-light-chain-trajectories-in-csf-and-plasma-39557867","doi":"10.1038/s41467-024-52937-8","journal":"Nature communications","n_participants":567,"pmid":"39557867","source_url":"https://pubmed.ncbi.nlm.nih.gov/39557867/","study_design":"cross-sectional","title":"Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/atg5-autophagy-related-5-in-microglia-controls-hippocampal-37915255","doi":"10.1080/15548627.2023.2277634","journal":"Autophagy","n_participants":null,"pmid":"37915255","source_url":"https://pubmed.ncbi.nlm.nih.gov/37915255/","study_design":null,"title":"ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease","title_match":false,"year":2024},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-in-the-dian-tu-001-trial-of-36151869","doi":"10.1002/ana.26511","journal":"Annals of neurology","n_participants":52,"pmid":"36151869","source_url":"https://pubmed.ncbi.nlm.nih.gov/36151869/","study_design":"cross-sectional","title":"Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease","title_match":true,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/preclinical-alzheimer-s-disease-biomarkers-accurately-predict-35867858","doi":"10.1093/brain/awac250","journal":"Brain : a journal of neurology","n_participants":720,"pmid":"35867858","source_url":"https://pubmed.ncbi.nlm.nih.gov/35867858/","study_design":"longitudinal study","title":"Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes","title_match":false,"year":2022},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-of-bdnf-val66met-with-tau-hyperphosphorylation-and-35099506","doi":"10.1001/jamaneurol.2021.5181","journal":"JAMA neurology","n_participants":527,"pmid":"35099506","source_url":"https://pubmed.ncbi.nlm.nih.gov/35099506/","study_design":"cohort study","title":"Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease","title_match":true,"year":2022},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-of-dutch-type-hereditary-cerebral-amyloid-angiopathy-31361916","doi":"10.1002/ana.25560","journal":"Annals of neurology","n_participants":null,"pmid":"31361916","source_url":"https://pubmed.ncbi.nlm.nih.gov/31361916/","study_design":"longitudinal study","title":"Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/comparing-cortical-signatures-of-atrophy-between-late-onset-and-33395982","doi":"10.1016/j.nicl.2020.102491","journal":"NeuroImage. Clinical","n_participants":588,"pmid":"33395982","source_url":"https://pubmed.ncbi.nlm.nih.gov/33395982/","study_design":null,"title":"Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease","title_match":true,"year":2020},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/downstream-biomarker-effects-of-gantenerumab-or-solanezumab-in-38683602","doi":"10.1001/jamaneurol.2024.0991","journal":"JAMA neurology","n_participants":142,"pmid":"38683602","source_url":"https://pubmed.ncbi.nlm.nih.gov/38683602/","study_design":"longitudinal study","title":"Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial","title_match":true,"year":2024},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/induction-of-apolipoprotein-e-mrna-in-the-hippocampus-of-the-gerbil-8737665","doi":"10.1016/0169-328x(95)00301-8","journal":"Brain research. Molecular brain research","n_participants":null,"pmid":"8737665","source_url":"https://pubmed.ncbi.nlm.nih.gov/8737665/","study_design":null,"title":"Induction of apolipoprotein E mRNA in the hippocampus of the gerbil after transient global ischemia","title_match":false,"year":1996},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/neuronal-pentraxin-1-a-synaptic-derived-plasma-biomarker-in-alzheimer-29501530","doi":"10.1016/j.nbd.2018.02.014","journal":"Neurobiology of disease","n_participants":null,"pmid":"29501530","source_url":"https://pubmed.ncbi.nlm.nih.gov/29501530/","study_design":null,"title":"Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/resting-state-functional-connectivity-disruption-as-a-pathological-33430685","doi":"10.1089/brain.2020.0808","journal":"Brain connectivity","n_participants":171,"pmid":"33430685","source_url":"https://pubmed.ncbi.nlm.nih.gov/33430685/","study_design":"cross-sectional","title":"Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease","title_match":true,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-pet-in-dementia-syndromes-a-chinese-multicenter-study-32385166","doi":"10.2967/jnumed.119.240325","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":null,"pmid":"32385166","source_url":"https://pubmed.ncbi.nlm.nih.gov/32385166/","study_design":null,"title":"Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study","title_match":false,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/experimental-evidence-for-temporal-uncoupling-of-brain-a-deposition-36443293","doi":"10.1038/s41467-022-34538-5","journal":"Nature communications","n_participants":null,"pmid":"36443293","source_url":"https://pubmed.ncbi.nlm.nih.gov/36443293/","study_design":null,"title":"Experimental evidence for temporal uncoupling of brain A\u03b2 deposition and neurodegenerative sequelae","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/diffusion-tensor-mri-structural-connectivity-and-pet-amyloid-burden-34636637","doi":"10.1148/radiol.2021210383","journal":"Radiology","n_participants":null,"pmid":"34636637","source_url":"https://pubmed.ncbi.nlm.nih.gov/34636637/","study_design":"cross-sectional","title":"Diffusion Tensor MRI Structural Connectivity and PET Amyloid Burden in Preclinical Autosomal Dominant Alzheimer Disease: The DIAN Cohort","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cognitively-normal-apoe-4-carriers-have-specific-elevation-of-csf-33765432","doi":"10.1016/j.neurobiolaging.2021.02.008","journal":"Neurobiology of aging","n_participants":274,"pmid":"33765432","source_url":"https://pubmed.ncbi.nlm.nih.gov/33765432/","study_design":null,"title":"Cognitively normal APOE \u03b54 carriers have specific elevation of CSF SNAP-25","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/simultaneously-evaluating-the-effect-of-baseline-levels-and-30569014","doi":"10.1016/j.trci.2018.10.009","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":262,"pmid":"30569014","source_url":"https://pubmed.ncbi.nlm.nih.gov/30569014/","study_design":"longitudinal study","title":"Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease","title_match":true,"year":2018},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/adult-onset-deactivation-of-autophagy-leads-to-loss-of-synapse-38949671","doi":"10.1080/15548627.2024.2368335","journal":"Autophagy","n_participants":null,"pmid":"38949671","source_url":"https://pubmed.ncbi.nlm.nih.gov/38949671/","study_design":null,"title":"Adult-onset deactivation of autophagy leads to loss of synapse homeostasis and cognitive impairment, with implications for alzheimer disease","title_match":false,"year":2024},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genetic-architecture-of-plasma-alzheimer-disease-biomarkers-37208024","doi":"10.1093/hmg/ddad087","journal":"Human molecular genetics","n_participants":1467,"pmid":"37208024","source_url":"https://pubmed.ncbi.nlm.nih.gov/37208024/","study_design":null,"title":"Genetic architecture of plasma Alzheimer disease biomarkers","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/amyloid-dependent-and-independent-genetic-pathways-regulating-csf-tau-35641311","doi":"10.1212/wnl.0000000000200605","journal":"Neurology","n_participants":751,"pmid":"35641311","source_url":"https://pubmed.ncbi.nlm.nih.gov/35641311/","study_design":null,"title":"\u03b2-Amyloid-Dependent and -Independent Genetic Pathways Regulating CSF Tau Biomarkers in Alzheimer Disease","title_match":false,"year":2022},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/machine-learning-models-of-polygenic-risk-for-enhanced-prediction-of-38250184","doi":"10.1212/nxg.0000000000200120","journal":"Neurology. Genetics","n_participants":1791,"pmid":"38250184","source_url":"https://pubmed.ncbi.nlm.nih.gov/38250184/","study_design":null,"title":"Machine Learning Models of Polygenic Risk for Enhanced Prediction of Alzheimer Disease Endophenotypes","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/advanced-structural-brain-aging-in-preclinical-autosomal-dominant-38111006","doi":"10.1186/s13024-023-00688-3","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"38111006","source_url":"https://pubmed.ncbi.nlm.nih.gov/38111006/","study_design":null,"title":"Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease","title_match":true,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/deconstructing-pathological-tau-by-biological-process-in-early-stages-38552342","doi":"10.1016/j.ebiom.2024.105080","journal":"EBioMedicine","n_participants":null,"pmid":"38552342","source_url":"https://pubmed.ncbi.nlm.nih.gov/38552342/","study_design":"cross-sectional","title":"Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/epileptic-seizures-induced-by-pentylenetetrazole-kindling-accelerate-39545066","doi":"10.3389/fphar.2024.1500105","journal":"Frontiers in pharmacology","n_participants":null,"pmid":"39545066","source_url":"https://pubmed.ncbi.nlm.nih.gov/39545066/","study_design":null,"title":"Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5\u00d7FAD mice","title_match":false,"year":2024},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/insulin-and-insulin-like-growth-factor-i-receptors-in-astrocytes-36636477","doi":"10.12688/f1000research.121901.3","journal":"F1000Research","n_participants":null,"pmid":"36636477","source_url":"https://pubmed.ncbi.nlm.nih.gov/36636477/","study_design":null,"title":"Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer\u00b4s-like pathology","title_match":false,"year":2022},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/metallothionein-i-ii-and-gfap-positivity-in-the-brains-from-16308479","doi":"10.3233/jad-2005-8203","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"16308479","source_url":"https://pubmed.ncbi.nlm.nih.gov/16308479/","study_design":null,"title":"Metallothionein-I-II and GFAP positivity in the brains from frontotemporal dementia patients","title_match":false,"year":2005},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/generalizability-of-tau-and-amyloid-plasma-biomarkers-in-alzheimer-s-40133765","doi":"10.1002/alz.14367","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2086,"pmid":"40133765","source_url":"https://pubmed.ncbi.nlm.nih.gov/40133765/","study_design":null,"title":"Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-high-avidity-binding-to-beta-amyloid-and-increased-8446617","doi":"10.1073/pnas.90.5.1977","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8446617","source_url":"https://pubmed.ncbi.nlm.nih.gov/8446617/","study_design":null,"title":"Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","title_match":true,"year":1993},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/protective-effect-of-apolipoprotein-e-type-2-allele-for-late-onset-7920638","doi":"10.1038/ng0694-180","journal":"Nature genetics","n_participants":null,"pmid":"7920638","source_url":"https://pubmed.ncbi.nlm.nih.gov/7920638/","study_design":null,"title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","title_match":false,"year":1994},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/systematic-meta-analyses-of-alzheimer-disease-genetic-association-17192785","doi":"10.1038/ng1934","journal":"Nature genetics","n_participants":null,"pmid":"17192785","source_url":"https://pubmed.ncbi.nlm.nih.gov/17192785/","study_design":"meta-analysis","title":"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database","title_match":false,"year":2007},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-pathobiology-and-targeting-31367008","doi":"10.1038/s41582-019-0228-7","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"31367008","source_url":"https://pubmed.ncbi.nlm.nih.gov/31367008/","study_design":null,"title":"Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies","title_match":false,"year":2019},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/apoe4-markedly-exacerbates-tau-mediated-neurodegeneration-in-a-mouse-28959956","doi":"10.1038/nature24016","journal":"Nature","n_participants":null,"pmid":"28959956","source_url":"https://pubmed.ncbi.nlm.nih.gov/28959956/","study_design":null,"title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/binding-of-human-apolipoprotein-e-to-synthetic-amyloid-beta-peptide-8367470","doi":"10.1073/pnas.90.17.8098","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8367470","source_url":"https://pubmed.ncbi.nlm.nih.gov/8367470/","study_design":null,"title":"Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease","title_match":false,"year":1993},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/sex-modifies-the-apoe-related-risk-of-developing-alzheimer-disease-24623176","doi":"10.1002/ana.24135","journal":"Annals of neurology","n_participants":5496,"pmid":"24623176","source_url":"https://pubmed.ncbi.nlm.nih.gov/24623176/","study_design":"case-control study","title":"Sex modifies the APOE-related risk of developing Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/endocytic-pathway-abnormalities-precede-amyloid-beta-deposition-in-10880397","doi":"10.1016/s0002-9440(10)64538-5","journal":"The American journal of pathology","n_participants":null,"pmid":"10880397","source_url":"https://pubmed.ncbi.nlm.nih.gov/10880397/","study_design":null,"title":"Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations","title_match":true,"year":2000},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-apolipoprotein-e-receptors-normal-biology-and-22393530","doi":"10.1101/cshperspect.a006312","journal":"Cold Spring Harbor perspectives in medicine","n_participants":null,"pmid":"22393530","source_url":"https://pubmed.ncbi.nlm.nih.gov/22393530/","study_design":null,"title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-genetic-landscape-of-alzheimer-disease-clinical-implications-and-26312828","doi":"10.1038/gim.2015.117","journal":"Genetics in medicine : official journal of the American College of Medical Genetics","n_participants":null,"pmid":"26312828","source_url":"https://pubmed.ncbi.nlm.nih.gov/26312828/","study_design":null,"title":"The genetic landscape of Alzheimer disease: clinical implications and perspectives","title_match":false,"year":2016},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-genetics-of-alzheimer-disease-23028126","doi":"10.1101/cshperspect.a006296","journal":"Cold Spring Harbor perspectives in medicine","n_participants":null,"pmid":"23028126","source_url":"https://pubmed.ncbi.nlm.nih.gov/23028126/","study_design":null,"title":"The genetics of Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-genetics-of-alzheimer-disease-back-to-the-future-20955934","doi":"10.1016/j.neuron.2010.10.013","journal":"Neuron","n_participants":null,"pmid":"20955934","source_url":"https://pubmed.ncbi.nlm.nih.gov/20955934/","study_design":null,"title":"The genetics of Alzheimer disease: back to the future","title_match":false,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/apoe-and-alzheimer-disease-a-major-gene-with-semi-dominant-inheritance-21556001","doi":"10.1038/mp.2011.52","journal":"Molecular psychiatry","n_participants":null,"pmid":"21556001","source_url":"https://pubmed.ncbi.nlm.nih.gov/21556001/","study_design":null,"title":"APOE and Alzheimer disease: a major gene with semi-dominant inheritance","title_match":true,"year":2011},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/interplay-between-innate-immunity-and-alzheimer-disease-apoe-and-30140051","doi":"10.1038/s41577-018-0051-1","journal":"Nature reviews. Immunology","n_participants":null,"pmid":"30140051","source_url":"https://pubmed.ncbi.nlm.nih.gov/30140051/","study_design":null,"title":"Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight","title_match":false,"year":2018},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-allele-elevated-midlife-total-cholesterol-12160362","doi":"10.7326/0003-4819-137-3-200208060-00006","journal":"Annals of internal medicine","n_participants":1449,"pmid":"12160362","source_url":"https://pubmed.ncbi.nlm.nih.gov/12160362/","study_design":null,"title":"Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease","title_match":false,"year":2002},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/symptom-onset-in-autosomal-dominant-alzheimer-disease-a-systematic-24928124","doi":"10.1212/wnl.0000000000000596","journal":"Neurology","n_participants":3275,"pmid":"24928124","source_url":"https://pubmed.ncbi.nlm.nih.gov/24928124/","study_design":null,"title":"Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis","title_match":true,"year":2014},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/alpha-2-macroglobulin-is-genetically-associated-with-alzheimer-disease-9697696","doi":"10.1038/1243","journal":"Nature genetics","n_participants":null,"pmid":"9697696","source_url":"https://pubmed.ncbi.nlm.nih.gov/9697696/","study_design":null,"title":"Alpha-2 macroglobulin is genetically associated with Alzheimer disease","title_match":false,"year":1998},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/the-probabilistic-model-of-alzheimer-disease-the-amyloid-hypothesis-34815562","doi":"10.1038/s41583-021-00533-w","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"34815562","source_url":"https://pubmed.ncbi.nlm.nih.gov/34815562/","study_design":null,"title":"The probabilistic model of Alzheimer disease: the amyloid hypothesis revised","title_match":false,"year":2022},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-type-4-allele-and-cerebral-glucose-metabolism-in-7884953","doi":"10.1001/jama.1995.03520360056039","journal":"JAMA","n_participants":12,"pmid":"7884953","source_url":"https://pubmed.ncbi.nlm.nih.gov/7884953/","study_design":"longitudinal study","title":"Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease","title_match":true,"year":1995},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/variants-in-the-atp-binding-cassette-transporter-abca7-apolipoprotein-23571587","doi":"10.1001/jama.2013.2973","journal":"JAMA","n_participants":5896,"pmid":"23571587","source_url":"https://pubmed.ncbi.nlm.nih.gov/23571587/","study_design":"meta-analysis","title":"Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E \u03f54,and the risk of late-onset Alzheimer disease in African Americans","title_match":false,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/candidate-single-nucleotide-polymorphisms-from-a-genomewide-17998437","doi":"10.1001/archneurol.2007.3","journal":"Archives of neurology","n_participants":753,"pmid":"17998437","source_url":"https://pubmed.ncbi.nlm.nih.gov/17998437/","study_design":"case-control study","title":"Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/trem2-variants-new-keys-to-decipher-alzheimer-disease-pathogenesis-26911435","doi":"10.1038/nrn.2016.7","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"26911435","source_url":"https://pubmed.ncbi.nlm.nih.gov/26911435/","study_design":null,"title":"TREM2 variants: new keys to decipher Alzheimer disease pathogenesis","title_match":false,"year":2016},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-allele-as-a-predictor-of-cholinergic-deficits-and-8618881","doi":"10.1073/pnas.92.26.12260","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":40,"pmid":"8618881","source_url":"https://pubmed.ncbi.nlm.nih.gov/8618881/","study_design":null,"title":"Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease","title_match":false,"year":1995},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/increased-expression-of-bin1-mediates-alzheimer-genetic-risk-by-23399914","doi":"10.1038/mp.2013.1","journal":"Molecular psychiatry","n_participants":null,"pmid":"23399914","source_url":"https://pubmed.ncbi.nlm.nih.gov/23399914/","study_design":"meta-analysis","title":"Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology","title_match":true,"year":2013},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/convergent-functional-genomics-of-schizophrenia-from-comprehensive-22584867","doi":"10.1038/mp.2012.37","journal":"Molecular psychiatry","n_participants":null,"pmid":"22584867","source_url":"https://pubmed.ncbi.nlm.nih.gov/22584867/","study_design":null,"title":"Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction","title_match":true,"year":2012},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-7761390","doi":"10.1073/pnas.92.11.4725","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7761390","source_url":"https://pubmed.ncbi.nlm.nih.gov/7761390/","study_design":null,"title":"Apolipoprotein E and Alzheimer disease","title_match":false,"year":1995},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/isoform-specific-interactions-of-apolipoprotein-e-with-microtubule-7972031","doi":"10.1073/pnas.91.23.11183","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7972031","source_url":"https://pubmed.ncbi.nlm.nih.gov/7972031/","study_design":null,"title":"Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease","title_match":false,"year":1994},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/genetic-assessment-of-age-associated-alzheimer-disease-risk-28323831","doi":"10.1371/journal.pmed.1002258","journal":"PLoS medicine","n_participants":null,"pmid":"28323831","source_url":"https://pubmed.ncbi.nlm.nih.gov/28323831/","study_design":null,"title":"Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score","title_match":true,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/overexpression-of-abca1-reduces-amyloid-deposition-in-the-pdapp-mouse-18202749","doi":"10.1172/jci33622","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"18202749","source_url":"https://pubmed.ncbi.nlm.nih.gov/18202749/","study_design":null,"title":"Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/sex-specific-association-of-apolipoprotein-e-with-cerebrospinal-fluid-29801024","doi":"10.1001/jamaneurol.2018.0821","journal":"JAMA neurology","n_participants":1798,"pmid":"29801024","source_url":"https://pubmed.ncbi.nlm.nih.gov/29801024/","study_design":"cohort study","title":"Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau","title_match":false,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/fmri-evidence-of-compensatory-mechanisms-in-older-adults-at-genetic-15699382","doi":"10.1212/01.wnl.0000150885.00929.7e","journal":"Neurology","n_participants":null,"pmid":"15699382","source_url":"https://pubmed.ncbi.nlm.nih.gov/15699382/","study_design":null,"title":"fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease","title_match":true,"year":2005},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/lack-of-abca1-considerably-decreases-brain-apoe-level-and-increases-16207713","doi":"10.1074/jbc.m504513200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16207713","source_url":"https://pubmed.ncbi.nlm.nih.gov/16207713/","study_design":null,"title":"Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice","title_match":false,"year":2005},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/risk-estimates-of-dementia-by-apolipoprotein-e-genotypes-from-a-9678314","doi":"10.1001/archneur.55.7.964","journal":"Archives of neurology","n_participants":134,"pmid":"9678314","source_url":"https://pubmed.ncbi.nlm.nih.gov/9678314/","study_design":"cohort study","title":"Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study","title_match":false,"year":1998},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/a-novel-alzheimer-disease-locus-located-near-the-gene-encoding-tau-25778476","doi":"10.1038/mp.2015.23","journal":"Molecular psychiatry","n_participants":4203,"pmid":"25778476","source_url":"https://pubmed.ncbi.nlm.nih.gov/25778476/","study_design":"meta-analysis","title":"A novel Alzheimer disease locus located near the gene encoding tau protein","title_match":false,"year":2016},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/novel-alzheimer-risk-genes-determine-the-microglia-response-to-31951107","doi":"10.15252/emmm.201910606","journal":"EMBO molecular medicine","n_participants":null,"pmid":"31951107","source_url":"https://pubmed.ncbi.nlm.nih.gov/31951107/","study_design":null,"title":"Novel Alzheimer risk genes determine the microglia response to amyloid-\u03b2 but not to TAU pathology","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-structural-insights-and-links-to-alzheimer-disease-33176118","doi":"10.1016/j.neuron.2020.10.008","journal":"Neuron","n_participants":null,"pmid":"33176118","source_url":"https://pubmed.ncbi.nlm.nih.gov/33176118/","study_design":null,"title":"Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe4-specific-changes-in-a-accumulation-in-a-new-transgenic-mouse-23060451","doi":"10.1074/jbc.m112.407957","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"23060451","source_url":"https://pubmed.ncbi.nlm.nih.gov/23060451/","study_design":null,"title":"APOE4-specific changes in A\u03b2 accumulation in a new transgenic mouse model of Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/whole-exome-sequencing-study-identifies-novel-rare-and-common-30108311","doi":"10.1038/s41380-018-0112-7","journal":"Molecular psychiatry","n_participants":null,"pmid":"30108311","source_url":"https://pubmed.ncbi.nlm.nih.gov/30108311/","study_design":null,"title":"Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cerebrovascular-effects-of-apolipoprotein-e-implications-for-23400708","doi":"10.1001/jamaneurol.2013.2152","journal":"JAMA neurology","n_participants":null,"pmid":"23400708","source_url":"https://pubmed.ncbi.nlm.nih.gov/23400708/","study_design":null,"title":"Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/early-onset-alzheimer-disease-and-its-variants-30707186","doi":"10.1212/con.0000000000000687","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"30707186","source_url":"https://pubmed.ncbi.nlm.nih.gov/30707186/","study_design":null,"title":"Early-onset Alzheimer Disease and Its Variants","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/brain-differences-in-infants-at-differential-genetic-risk-for-late-24276092","doi":"10.1001/jamaneurol.2013.4544","journal":"JAMA neurology","n_participants":null,"pmid":"24276092","source_url":"https://pubmed.ncbi.nlm.nih.gov/24276092/","study_design":"cross-sectional","title":"Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study","title_match":true,"year":2014},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-dyrk1a-gene-encoded-in-chromosome-21-down-syndrome-critical-17135279","doi":"10.1093/hmg/ddl437","journal":"Human molecular genetics","n_participants":null,"pmid":"17135279","source_url":"https://pubmed.ncbi.nlm.nih.gov/17135279/","study_design":null,"title":"The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease","title_match":false,"year":2007},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/association-of-chronic-low-grade-inflammation-with-risk-of-alzheimer-30646251","doi":"10.1001/jamanetworkopen.2018.3597","journal":"JAMA network open","n_participants":null,"pmid":"30646251","source_url":"https://pubmed.ncbi.nlm.nih.gov/30646251/","study_design":"cohort study","title":"Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/age-at-onset-in-two-common-neurodegenerative-diseases-is-genetically-11875758","doi":"10.1086/339815","journal":"American journal of human genetics","n_participants":449,"pmid":"11875758","source_url":"https://pubmed.ncbi.nlm.nih.gov/11875758/","study_design":null,"title":"Age at onset in two common neurodegenerative diseases is genetically controlled","title_match":false,"year":2002},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/modification-of-the-relationship-of-the-apolipoprotein-e-4-allele-to-24145819","doi":"10.1001/jamaneurol.2013.4215","journal":"JAMA neurology","n_participants":698,"pmid":"24145819","source_url":"https://pubmed.ncbi.nlm.nih.gov/24145819/","study_design":"cohort study","title":"Modification of the relationship of the apolipoprotein E \u03b54 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep","title_match":false,"year":2013},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-and-the-risk-of-dementia-with-stroke-a-9052712","doi":"10.1001/jama.277.10.818","journal":"JAMA","n_participants":187,"pmid":"9052712","source_url":"https://pubmed.ncbi.nlm.nih.gov/9052712/","study_design":"case-control study","title":"Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation","title_match":false,"year":1997},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/complete-genomic-screen-in-late-onset-familial-alzheimer-disease-9333264","doi":"10.1001/jama.1997.03550150041033","journal":"JAMA","n_participants":280,"pmid":"9333264","source_url":"https://pubmed.ncbi.nlm.nih.gov/9333264/","study_design":null,"title":"Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12","title_match":true,"year":1997},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/apoe-epsilon4-genotype-and-longitudinal-changes-in-cerebral-blood-20065135","doi":"10.1001/archneurol.2009.913","journal":"Archives of neurology","n_participants":null,"pmid":"20065135","source_url":"https://pubmed.ncbi.nlm.nih.gov/20065135/","study_design":"longitudinal study","title":"APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging","title_match":false,"year":2010},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/apoe-isoform-dependent-sars-cov-2-neurotropism-and-cellular-response-33450186","doi":"10.1016/j.stem.2020.12.018","journal":"Cell stem cell","n_participants":null,"pmid":"33450186","source_url":"https://pubmed.ncbi.nlm.nih.gov/33450186/","study_design":null,"title":"ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/health-behavior-changes-after-genetic-risk-assessment-for-alzheimer-18317253","doi":"10.1097/wad.0b013e31815a9dcc","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"18317253","source_url":"https://pubmed.ncbi.nlm.nih.gov/18317253/","study_design":null,"title":"Health behavior changes after genetic risk assessment for Alzheimer disease: The REVEAL Study","title_match":true,"year":2008},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/ancestral-origin-of-apoe-4-alzheimer-disease-risk-in-puerto-rican-and-30517106","doi":"10.1371/journal.pgen.1007791","journal":"PLoS genetics","n_participants":1766,"pmid":"30517106","source_url":"https://pubmed.ncbi.nlm.nih.gov/30517106/","study_design":null,"title":"Ancestral origin of ApoE \u03b54 Alzheimer disease risk in Puerto Rican and African American populations","title_match":false,"year":2018},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/longitudinal-changes-in-cognition-and-behavior-in-asymptomatic-15184602","doi":"10.1212/01.wnl.0000129533.26544.bf","journal":"Neurology","n_participants":212,"pmid":"15184602","source_url":"https://pubmed.ncbi.nlm.nih.gov/15184602/","study_design":"longitudinal study","title":"Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele","title_match":false,"year":2004},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/cerebral-small-vessel-disease-genomics-and-its-implications-across-33293549","doi":"10.1038/s41467-020-19111-2","journal":"Nature communications","n_participants":null,"pmid":"33293549","source_url":"https://pubmed.ncbi.nlm.nih.gov/33293549/","study_design":null,"title":"Cerebral small vessel disease genomics and its implications across the lifespan","title_match":false,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/age-dependent-effects-of-apoe-reduction-using-antisense-29216448","doi":"10.1016/j.neuron.2017.11.014","journal":"Neuron","n_participants":null,"pmid":"29216448","source_url":"https://pubmed.ncbi.nlm.nih.gov/29216448/","study_design":null,"title":"Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of \u03b2-amyloidosis","title_match":false,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-absence-of-abca1-decreases-soluble-apoe-levels-but-does-not-16207707","doi":"10.1074/jbc.m508781200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16207707","source_url":"https://pubmed.ncbi.nlm.nih.gov/16207707/","study_design":null,"title":"The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease","title_match":false,"year":2005},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cell-type-specific-roles-of-apoe4-in-alzheimer-disease-38191720","doi":"10.1038/s41583-023-00776-9","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"38191720","source_url":"https://pubmed.ncbi.nlm.nih.gov/38191720/","study_design":null,"title":"Cell type-specific roles of APOE4 in Alzheimer disease","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/hiv-infected-subjects-with-the-e4-allele-for-apoe-have-excess-9771753","doi":"10.1038/2677","journal":"Nature medicine","n_participants":null,"pmid":"9771753","source_url":"https://pubmed.ncbi.nlm.nih.gov/9771753/","study_design":null,"title":"HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy","title_match":false,"year":1998},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gender-difference-in-apolipoprotein-e-associated-risk-for-familial-8644745","doi":null,"journal":"American journal of human genetics","n_participants":58,"pmid":"8644745","source_url":"https://pubmed.ncbi.nlm.nih.gov/8644745/","study_design":null,"title":"Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women","title_match":true,"year":1996},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-domain-interaction-mediates-detrimental-effects-on-21118811","doi":"10.1074/jbc.m110.151084","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"21118811","source_url":"https://pubmed.ncbi.nlm.nih.gov/21118811/","study_design":null,"title":"Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/atp-binding-cassette-transporter-a1-mediates-the-beneficial-effects-20739291","doi":"10.1074/jbc.m110.108100","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"20739291","source_url":"https://pubmed.ncbi.nlm.nih.gov/20739291/","study_design":null,"title":"ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice","title_match":true,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/exploring-the-etiology-of-alzheimer-disease-using-molecular-genetics-9052714","doi":"10.1001/jama.1997.03540340059034","journal":"JAMA","n_participants":null,"pmid":"9052714","source_url":"https://pubmed.ncbi.nlm.nih.gov/9052714/","study_design":null,"title":"Exploring the etiology of Alzheimer disease using molecular genetics","title_match":false,"year":1997},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/oxidative-damage-and-protection-by-antioxidants-in-the-frontal-cortex-10490274","doi":"10.1016/s0891-5849(99)00102-1","journal":"Free radical biology & medicine","n_participants":null,"pmid":"10490274","source_url":"https://pubmed.ncbi.nlm.nih.gov/10490274/","study_design":null,"title":"Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype","title_match":false,"year":1999},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-analysis-of-pathologically-confirmed-alzheimer-28727176","doi":"10.1002/ana.24999","journal":"Annals of neurology","n_participants":null,"pmid":"28727176","source_url":"https://pubmed.ncbi.nlm.nih.gov/28727176/","study_design":"case-control study","title":"Polygenic risk score analysis of pathologically confirmed Alzheimer disease","title_match":true,"year":2017},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/polygenic-risk-of-alzheimer-disease-is-associated-with-early-and-late-27385740","doi":"10.1212/wnl.0000000000002922","journal":"Neurology","n_participants":null,"pmid":"27385740","source_url":"https://pubmed.ncbi.nlm.nih.gov/27385740/","study_design":"cohort study","title":"Polygenic risk of Alzheimer disease is associated with early- and late-life processes","title_match":true,"year":2016},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/clinical-predictors-of-progression-to-alzheimer-disease-in-amnestic-17287448","doi":"10.1212/01.wnl.0000258542.58725.4c","journal":"Neurology","n_participants":539,"pmid":"17287448","source_url":"https://pubmed.ncbi.nlm.nih.gov/17287448/","study_design":null,"title":"Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/multiethnic-genome-wide-association-study-of-cerebral-white-matter-25663218","doi":"10.1161/circgenetics.114.000858","journal":"Circulation. Cardiovascular genetics","n_participants":17,"pmid":"25663218","source_url":"https://pubmed.ncbi.nlm.nih.gov/25663218/","study_design":"meta-analysis","title":"Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/indicators-of-amyloid-burden-in-a-population-based-study-of-22972644","doi":"10.1212/wnl.0b013e31826e2696","journal":"Neurology","n_participants":100,"pmid":"22972644","source_url":"https://pubmed.ncbi.nlm.nih.gov/22972644/","study_design":null,"title":"Indicators of amyloid burden in a population-based study of cognitively normal elderly","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-role-of-apoe-and-trem2-in-alzheimer-s-disease-current-30587772","doi":"10.3390/ijms20010081","journal":"International journal of molecular sciences","n_participants":null,"pmid":"30587772","source_url":"https://pubmed.ncbi.nlm.nih.gov/30587772/","study_design":null,"title":"The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives","title_match":false,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-oxidative-stress-in-brain-with-relevance-to-32036033","doi":"10.1016/j.nbd.2020.104795","journal":"Neurobiology of disease","n_participants":null,"pmid":"32036033","source_url":"https://pubmed.ncbi.nlm.nih.gov/32036033/","study_design":null,"title":"Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/sex-driven-modifiers-of-alzheimer-risk-a-multimodality-brain-imaging-32580974","doi":"10.1212/wnl.0000000000009781","journal":"Neurology","n_participants":null,"pmid":"32580974","source_url":"https://pubmed.ncbi.nlm.nih.gov/32580974/","study_design":null,"title":"Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study","title_match":false,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/posterior-cingulate-glucose-metabolism-hippocampal-glucose-metabolism-23599929","doi":"10.1001/2013.jamaneurol.286","journal":"JAMA neurology","n_participants":31,"pmid":"23599929","source_url":"https://pubmed.ncbi.nlm.nih.gov/23599929/","study_design":"cross-sectional","title":"Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease","title_match":true,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/contribution-to-alzheimer-s-disease-risk-of-rare-variants-in-trem2-28789839","doi":"10.1016/j.neurobiolaging.2017.07.001","journal":"Neurobiology of aging","n_participants":null,"pmid":"28789839","source_url":"https://pubmed.ncbi.nlm.nih.gov/28789839/","study_design":null,"title":"Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls","title_match":false,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/genome-wide-association-studies-in-alzheimer-disease-18332245","doi":"10.1001/archneur.65.3.329","journal":"Archives of neurology","n_participants":null,"pmid":"18332245","source_url":"https://pubmed.ncbi.nlm.nih.gov/18332245/","study_design":null,"title":"Genome-wide association studies in Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-apolipoprotein-e-and-risk-of-dementia-in-the-general-25469919","doi":"10.1002/ana.24326","journal":"Annals of neurology","n_participants":75708,"pmid":"25469919","source_url":"https://pubmed.ncbi.nlm.nih.gov/25469919/","study_design":null,"title":"Plasma levels of apolipoprotein E and risk of dementia in the general population","title_match":false,"year":2015},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/increased-risk-of-late-posttraumatic-seizures-associated-with-12810485","doi":"10.1001/archneur.60.6.818","journal":"Archives of neurology","n_participants":106,"pmid":"12810485","source_url":"https://pubmed.ncbi.nlm.nih.gov/12810485/","study_design":null,"title":"Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele","title_match":true,"year":2003},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/characterization-of-pathogenic-sorl1-genetic-variants-for-association-28537274","doi":"10.1038/ejhg.2017.87","journal":"European journal of human genetics : EJHG","n_participants":null,"pmid":"28537274","source_url":"https://pubmed.ncbi.nlm.nih.gov/28537274/","study_design":null,"title":"Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy","title_match":false,"year":2017},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/apoe-related-risk-of-mild-cognitive-impairment-and-dementia-for-28323826","doi":"10.1371/journal.pmed.1002254","journal":"PLoS medicine","n_participants":5073,"pmid":"28323826","source_url":"https://pubmed.ncbi.nlm.nih.gov/28323826/","study_design":null,"title":"APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/genetic-association-between-intronic-polymorphism-in-presenilin-1-8596269","doi":"10.1016/s0140-6736(96)91140-x","journal":"Lancet (London, England)","n_participants":29,"pmid":"8596269","source_url":"https://pubmed.ncbi.nlm.nih.gov/8596269/","study_design":null,"title":"Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group","title_match":true,"year":1996},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/altered-brain-white-matter-integrity-in-healthy-carriers-of-the-apoe-16606914","doi":"10.1212/01.wnl.0000204180.25361.48","journal":"Neurology","n_participants":null,"pmid":"16606914","source_url":"https://pubmed.ncbi.nlm.nih.gov/16606914/","study_design":null,"title":"Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?","title_match":false,"year":2006},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/levels-of-soluble-apolipoprotein-e-amyloid-a-complex-are-reduced-and-23293020","doi":"10.1074/jbc.m112.442103","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"23293020","source_url":"https://pubmed.ncbi.nlm.nih.gov/23293020/","study_design":null,"title":"Levels of soluble apolipoprotein E/amyloid-\u03b2 (A\u03b2) complex are reduced and oligomeric A\u03b2 increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/a-global-view-of-the-genetic-basis-of-alzheimer-disease-37024647","doi":"10.1038/s41582-023-00789-z","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"37024647","source_url":"https://pubmed.ncbi.nlm.nih.gov/37024647/","study_design":null,"title":"A global view of the genetic basis of Alzheimer disease","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/advanced-brain-aging-relationship-with-epidemiologic-and-genetic-risk-27045845","doi":"10.1038/tp.2016.39","journal":"Translational psychiatry","n_participants":2705,"pmid":"27045845","source_url":"https://pubmed.ncbi.nlm.nih.gov/27045845/","study_design":null,"title":"Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns","title_match":true,"year":2016},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/late-onset-alzheimer-disease-30707185","doi":"10.1212/con.0000000000000700","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"30707185","source_url":"https://pubmed.ncbi.nlm.nih.gov/30707185/","study_design":null,"title":"Late-onset Alzheimer Disease","title_match":false,"year":2019},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/lack-of-hepatic-apoe-does-not-influence-early-a-deposition-31623648","doi":"10.1186/s13024-019-0337-1","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31623648","source_url":"https://pubmed.ncbi.nlm.nih.gov/31623648/","study_design":null,"title":"Lack of hepatic apoE does not influence early A\u03b2 deposition: observations from a new APOE knock-in model","title_match":false,"year":2019},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/volumetric-mri-vs-clinical-predictors-of-alzheimer-disease-in-mild-18195264","doi":"10.1212/01.wnl.0000287091.57376.65","journal":"Neurology","n_participants":129,"pmid":"18195264","source_url":"https://pubmed.ncbi.nlm.nih.gov/18195264/","study_design":null,"title":"Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment","title_match":false,"year":2008},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-count-affects-age-at-onset-of-alzheimer-15123497","doi":"10.1001/archpsyc.61.5.518","journal":"Archives of general psychiatry","n_participants":3308,"pmid":"15123497","source_url":"https://pubmed.ncbi.nlm.nih.gov/15123497/","study_design":"longitudinal study","title":"Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study","title_match":false,"year":2004},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/why-are-stroke-patients-prone-to-develop-dementia-9050953","doi":"10.1007/s004150050064","journal":"Journal of neurology","n_participants":null,"pmid":"9050953","source_url":"https://pubmed.ncbi.nlm.nih.gov/9050953/","study_design":null,"title":"Why are stroke patients prone to develop dementia?","title_match":false,"year":1997},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lr11-sorla-expression-is-reduced-in-sporadic-alzheimer-disease-but-16957580","doi":"10.1097/01.jnen.0000228205.19915.20","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"16957580","source_url":"https://pubmed.ncbi.nlm.nih.gov/16957580/","study_design":null,"title":"LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease","title_match":true,"year":2006},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/white-matter-lesions-spatial-heterogeneity-links-to-risk-factors-30076276","doi":"10.1212/wnl.0000000000006116","journal":"Neurology","n_participants":1836,"pmid":"30076276","source_url":"https://pubmed.ncbi.nlm.nih.gov/30076276/","study_design":"cross-sectional","title":"White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy","title_match":false,"year":2018},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/polygenic-overlap-between-c-reactive-protein-plasma-lipids-and-25862742","doi":"10.1161/circulationaha.115.015489","journal":"Circulation","n_participants":null,"pmid":"25862742","source_url":"https://pubmed.ncbi.nlm.nih.gov/25862742/","study_design":null,"title":"Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease","title_match":true,"year":2015},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/associations-between-handgrip-strength-and-dementia-risk-cognition-35737388","doi":"10.1001/jamanetworkopen.2022.18314","journal":"JAMA network open","n_participants":null,"pmid":"35737388","source_url":"https://pubmed.ncbi.nlm.nih.gov/35737388/","study_design":"cohort study","title":"Associations Between Handgrip Strength and Dementia Risk, Cognition, and Neuroimaging Outcomes in the UK Biobank Cohort Study","title_match":false,"year":2022},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/clathrin-adaptor-calm-picalm-is-associated-with-neurofibrillary-23589030","doi":"10.1007/s00401-013-1111-z","journal":"Acta neuropathologica","n_participants":null,"pmid":"23589030","source_url":"https://pubmed.ncbi.nlm.nih.gov/23589030/","study_design":null,"title":"Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains","title_match":false,"year":2013},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-influence-of-alzheimer-disease-family-history-and-apolipoprotein-16738250","doi":"10.1523/jneurosci.0959-06.2006","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"16738250","source_url":"https://pubmed.ncbi.nlm.nih.gov/16738250/","study_design":null,"title":"The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation","title_match":true,"year":2006},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/clinical-features-and-apoe-genotype-of-pathologically-proven-early-21576687","doi":"10.1212/wnl.0b013e31821a44dd","journal":"Neurology","n_participants":37,"pmid":"21576687","source_url":"https://pubmed.ncbi.nlm.nih.gov/21576687/","study_design":null,"title":"Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/inferring-relevant-cell-types-for-complex-traits-by-using-single-cell-29106824","doi":"10.1016/j.ajhg.2017.09.009","journal":"American journal of human genetics","n_participants":null,"pmid":"29106824","source_url":"https://pubmed.ncbi.nlm.nih.gov/29106824/","study_design":null,"title":"Inferring Relevant Cell Types for Complex Traits by Using Single-Cell Gene Expression","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/neuronal-apolipoprotein-e4-increases-cell-death-and-phosphorylated-30840313","doi":"10.1002/ana.25455","journal":"Annals of neurology","n_participants":null,"pmid":"30840313","source_url":"https://pubmed.ncbi.nlm.nih.gov/30840313/","study_design":null,"title":"Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease","title_match":false,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/current-status-on-alzheimer-disease-molecular-genetics-from-past-to-20388643","doi":"10.1093/hmg/ddq142","journal":"Human molecular genetics","n_participants":null,"pmid":"20388643","source_url":"https://pubmed.ncbi.nlm.nih.gov/20388643/","study_design":null,"title":"Current status on Alzheimer disease molecular genetics: from past, to present, to future","title_match":false,"year":2010},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-association-between-a-polygenic-alzheimer-score-and-cortical-22169231","doi":"10.1093/cercor/bhr348","journal":"Cerebral cortex (New York, N.Y. : 1991)","n_participants":104,"pmid":"22169231","source_url":"https://pubmed.ncbi.nlm.nih.gov/22169231/","study_design":null,"title":"The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects","title_match":true,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-controls-the-risk-and-age-at-onset-of-parkinson-15184605","doi":"10.1212/01.wnl.0000128089.53030.ac","journal":"Neurology","n_participants":null,"pmid":"15184605","source_url":"https://pubmed.ncbi.nlm.nih.gov/15184605/","study_design":"case-control study","title":"Apolipoprotein E controls the risk and age at onset of Parkinson disease","title_match":false,"year":2004},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/microglial-activation-in-alzheimer-disease-association-with-apoe-9669695","doi":"10.1111/j.1750-3639.1998.tb00166.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"9669695","source_url":"https://pubmed.ncbi.nlm.nih.gov/9669695/","study_design":null,"title":"Microglial activation in Alzheimer disease: Association with APOE genotype","title_match":false,"year":1998},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/single-nucleus-rna-sequencing-of-autosomal-dominant-alzheimer-disease-37085492","doi":"10.1038/s41467-023-37437-5","journal":"Nature communications","n_participants":null,"pmid":"37085492","source_url":"https://pubmed.ncbi.nlm.nih.gov/37085492/","study_design":null,"title":"Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers","title_match":true,"year":2023},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/melatonin-reverses-the-profibrillogenic-activity-of-apolipoprotein-e4-11732920","doi":"10.1021/bi0114269","journal":"Biochemistry","n_participants":null,"pmid":"11732920","source_url":"https://pubmed.ncbi.nlm.nih.gov/11732920/","study_design":null,"title":"Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide","title_match":false,"year":2001},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/association-of-apoe-4-genotype-and-lifestyle-with-cognitive-function-34061824","doi":"10.1371/journal.pmed.1003597","journal":"PLoS medicine","n_participants":null,"pmid":"34061824","source_url":"https://pubmed.ncbi.nlm.nih.gov/34061824/","study_design":"cohort study","title":"Association of APOE \u03b54 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-apolipoprotein-e-apoe-genotype-and-risk-of-dementia-28340945","doi":"10.1016/j.atherosclerosis.2016.10.037","journal":"Atherosclerosis","n_participants":null,"pmid":"28340945","source_url":"https://pubmed.ncbi.nlm.nih.gov/28340945/","study_design":null,"title":"Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review","title_match":false,"year":2016},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-alzheimer-s-disease-with-psychotic-22005930","doi":"10.1038/mp.2011.125","journal":"Molecular psychiatry","n_participants":null,"pmid":"22005930","source_url":"https://pubmed.ncbi.nlm.nih.gov/22005930/","study_design":null,"title":"Genome-wide association study of Alzheimer's disease with psychotic symptoms","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-clinical-introduction-of-genetic-testing-for-alzheimer-disease-an-9052715","doi":"10.1001/jama.277.10.832","journal":"JAMA","n_participants":20,"pmid":"9052715","source_url":"https://pubmed.ncbi.nlm.nih.gov/9052715/","study_design":null,"title":"The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective","title_match":false,"year":1997},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/apoe2-e3-and-e4-differentially-modulate-cellular-homeostasis-34919811","doi":"10.1016/j.stemcr.2021.11.007","journal":"Stem cell reports","n_participants":null,"pmid":"34919811","source_url":"https://pubmed.ncbi.nlm.nih.gov/34919811/","study_design":null,"title":"APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes","title_match":false,"year":2022},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/distribution-of-reducible-4-hydroxynonenal-adduct-immunoreactivity-in-9596412","doi":"10.1097/00005072-199805000-00005","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"9596412","source_url":"https://pubmed.ncbi.nlm.nih.gov/9596412/","study_design":null,"title":"Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype","title_match":false,"year":1998},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/senile-dementia-with-tangles-tangle-predominant-form-of-senile-9546293","doi":"10.1111/j.1750-3639.1998.tb00160.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"9546293","source_url":"https://pubmed.ncbi.nlm.nih.gov/9546293/","study_design":null,"title":"Senile dementia with tangles (tangle predominant form of senile dementia)","title_match":false,"year":1998},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-risk-for-alzheimer-disease-is-distinct-from-genetic-risk-for-31199530","doi":"10.1002/ana.25530","journal":"Annals of neurology","n_participants":null,"pmid":"31199530","source_url":"https://pubmed.ncbi.nlm.nih.gov/31199530/","study_design":null,"title":"Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition","title_match":true,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/associations-of-the-top-20-alzheimer-disease-risk-variants-with-brain-29340569","doi":"10.1001/jamaneurol.2017.4198","journal":"JAMA neurology","n_participants":977,"pmid":"29340569","source_url":"https://pubmed.ncbi.nlm.nih.gov/29340569/","study_design":null,"title":"Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-an-update-on-genetic-and-11005255","doi":"10.1093/jnen/59.9.751","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"11005255","source_url":"https://pubmed.ncbi.nlm.nih.gov/11005255/","study_design":null,"title":"Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses","title_match":false,"year":2000},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/brain-volume-changes-in-cadasil-a-serial-mri-study-in-pure-16717211","doi":"10.1212/01.wnl.0000216271.96364.50","journal":"Neurology","n_participants":null,"pmid":"16717211","source_url":"https://pubmed.ncbi.nlm.nih.gov/16717211/","study_design":"cross-sectional","title":"Brain volume changes in CADASIL: a serial MRI study in pure subcortical ischemic vascular disease","title_match":false,"year":2006},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-loneliness-with-10-year-dementia-risk-and-early-35131906","doi":"10.1212/wnl.0000000000200039","journal":"Neurology","n_participants":2308,"pmid":"35131906","source_url":"https://pubmed.ncbi.nlm.nih.gov/35131906/","study_design":"cohort study","title":"Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-isoform-affects-ltp-in-human-targeted-replacement-mice-15570172","doi":"10.1097/00001756-200412030-00020","journal":"Neuroreport","n_participants":null,"pmid":"15570172","source_url":"https://pubmed.ncbi.nlm.nih.gov/15570172/","study_design":null,"title":"ApoE isoform affects LTP in human targeted replacement mice","title_match":false,"year":2004},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/apoe-genotype-family-history-of-dementia-and-alzheimer-disease-risk-a-15596614","doi":"10.1001/archneur.61.12.1930","journal":"Archives of neurology","n_participants":907,"pmid":"15596614","source_url":"https://pubmed.ncbi.nlm.nih.gov/15596614/","study_design":"cohort study","title":"APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study","title_match":true,"year":2004},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/single-and-multiple-transgenic-mice-as-models-for-alzheimer-s-disease-10727777","doi":"10.1016/s0301-0082(99)00055-6","journal":"Progress in neurobiology","n_participants":null,"pmid":"10727777","source_url":"https://pubmed.ncbi.nlm.nih.gov/10727777/","study_design":null,"title":"Single and multiple transgenic mice as models for Alzheimer's disease","title_match":false,"year":2000},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/evidence-for-an-alzheimer-disease-susceptibility-locus-on-chromosome-9718052","doi":"10.1001/jama.280.7.614","journal":"JAMA","n_participants":173,"pmid":"9718052","source_url":"https://pubmed.ncbi.nlm.nih.gov/9718052/","study_design":"cohort study","title":"Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity","title_match":false,"year":1998},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/frequency-of-the-apolipoprotein-e-epsilon-2-allele-is-diminished-in-7970208","doi":"10.1016/0304-3940(94)91074-x","journal":"Neuroscience letters","n_participants":null,"pmid":"7970208","source_url":"https://pubmed.ncbi.nlm.nih.gov/7970208/","study_design":null,"title":"Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease","title_match":false,"year":1994},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genetic-association-study-on-in-and-around-the-apoe-in-late-onset-19442637","doi":"10.1016/j.ygeno.2009.01.003","journal":"Genomics","n_participants":null,"pmid":"19442637","source_url":"https://pubmed.ncbi.nlm.nih.gov/19442637/","study_design":"case-control study","title":"Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese","title_match":false,"year":2009},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-genetic-landscape-of-alzheimer-disease-29478590","doi":"10.1016/b978-0-444-64076-5.00026-0","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"29478590","source_url":"https://pubmed.ncbi.nlm.nih.gov/29478590/","study_design":null,"title":"The genetic landscape of Alzheimer disease","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/bin1-regulates-bace1-intracellular-trafficking-and-amyloid-production-27179792","doi":"10.1093/hmg/ddw146","journal":"Human molecular genetics","n_participants":null,"pmid":"27179792","source_url":"https://pubmed.ncbi.nlm.nih.gov/27179792/","study_design":null,"title":"BIN1 regulates BACE1 intracellular trafficking and amyloid-\u03b2 production","title_match":false,"year":2016},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/lrp10-genetic-variants-in-familial-parkinson-s-disease-and-dementia-29887161","doi":"10.1016/s1474-4422(18)30179-0","journal":"The Lancet. Neurology","n_participants":null,"pmid":"29887161","source_url":"https://pubmed.ncbi.nlm.nih.gov/29887161/","study_design":null,"title":"LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study","title_match":true,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/association-and-expression-analyses-with-single-nucleotide-21825236","doi":"10.1001/archneurol.2011.155","journal":"Archives of neurology","n_participants":null,"pmid":"21825236","source_url":"https://pubmed.ncbi.nlm.nih.gov/21825236/","study_design":"case-control study","title":"Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cognitive-performance-in-older-women-relative-to-apoe-epsilon4-17218903","doi":"10.1249/01.mss.0000239399.85955.5e","journal":"Medicine and science in sports and exercise","n_participants":90,"pmid":"17218903","source_url":"https://pubmed.ncbi.nlm.nih.gov/17218903/","study_design":null,"title":"Cognitive performance in older women relative to ApoE-epsilon4 genotype and aerobic fitness","title_match":false,"year":2007},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/dura-mater-is-a-potential-source-of-a-seeds-27016065","doi":"10.1007/s00401-016-1565-x","journal":"Acta neuropathologica","n_participants":null,"pmid":"27016065","source_url":"https://pubmed.ncbi.nlm.nih.gov/27016065/","study_design":null,"title":"Dura mater is a potential source of A\u03b2 seeds","title_match":false,"year":2016},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/comprehensive-search-for-alzheimer-disease-susceptibility-loci-in-the-22869155","doi":"10.1001/archneurol.2012.2052","journal":"Archives of neurology","n_participants":null,"pmid":"22869155","source_url":"https://pubmed.ncbi.nlm.nih.gov/22869155/","study_design":null,"title":"Comprehensive search for Alzheimer disease susceptibility loci in the APOE region","title_match":false,"year":2012},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/glutathione-s-transferase-omega-genes-in-alzheimer-and-parkinson-22494505","doi":"10.1186/1750-1326-7-13","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"22494505","source_url":"https://pubmed.ncbi.nlm.nih.gov/22494505/","study_design":null,"title":"Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/selective-genetic-overlap-between-amyotrophic-lateral-sclerosis-and-29630712","doi":"10.1001/jamaneurol.2018.0372","journal":"JAMA neurology","n_participants":null,"pmid":"29630712","source_url":"https://pubmed.ncbi.nlm.nih.gov/29630712/","study_design":null,"title":"Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/genotype-patterns-at-picalm-cr1-bin1-clu-and-apoe-genes-are-22539578","doi":"10.1212/wnl.0b013e3182553c48","journal":"Neurology","n_participants":1365,"pmid":"22539578","source_url":"https://pubmed.ncbi.nlm.nih.gov/22539578/","study_design":null,"title":"Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/an-inherited-variable-poly-t-repeat-genotype-in-tomm40-in-alzheimer-20457951","doi":"10.1001/archneurol.2010.88","journal":"Archives of neurology","n_participants":null,"pmid":"20457951","source_url":"https://pubmed.ncbi.nlm.nih.gov/20457951/","study_design":null,"title":"An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease","title_match":true,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/genetic-heterogeneity-in-alzheimer-disease-and-implications-for-25217249","doi":"10.1007/s11910-014-0499-8","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"25217249","source_url":"https://pubmed.ncbi.nlm.nih.gov/25217249/","study_design":null,"title":"Genetic heterogeneity in Alzheimer disease and implications for treatment strategies","title_match":false,"year":2014},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/progressive-regional-atrophy-in-normal-adults-with-a-maternal-history-21357834","doi":"10.1212/wnl.0b013e31820e7b74","journal":"Neurology","n_participants":null,"pmid":"21357834","source_url":"https://pubmed.ncbi.nlm.nih.gov/21357834/","study_design":"longitudinal study","title":"Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/genetic-study-of-white-matter-integrity-in-uk-biobank-n-8448-and-the-29752348","doi":"10.1161/strokeaha.118.020811","journal":"Stroke","n_participants":8448,"pmid":"29752348","source_url":"https://pubmed.ncbi.nlm.nih.gov/29752348/","study_design":"cohort study","title":"Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia","title_match":false,"year":2018},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/dissociable-influences-of-i-apoe-i-4-and-polygenic-risk-of-ad-29592889","doi":"10.1212/wnl.0000000000005415","journal":"Neurology","n_participants":702,"pmid":"29592889","source_url":"https://pubmed.ncbi.nlm.nih.gov/29592889/","study_design":"longitudinal study","title":"Dissociable influences of APOE \u03b54 and polygenic risk of AD dementia on amyloid and cognition","title_match":true,"year":2018},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/fine-mapping-of-the-human-leukocyte-antigen-locus-as-a-risk-factor-28350795","doi":"10.1371/journal.pmed.1002272","journal":"PLoS medicine","n_participants":346,"pmid":"28350795","source_url":"https://pubmed.ncbi.nlm.nih.gov/28350795/","study_design":"case-control study","title":"Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/investigation-of-c9orf72-in-4-neurodegenerative-disorders-22964832","doi":"10.1001/archneurol.2012.2016","journal":"Archives of neurology","n_participants":520,"pmid":"22964832","source_url":"https://pubmed.ncbi.nlm.nih.gov/22964832/","study_design":null,"title":"Investigation of c9orf72 in 4 neurodegenerative disorders","title_match":false,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/myo-inositol-changes-precede-amyloid-pathology-and-relate-to-apoe-27164711","doi":"10.1212/wnl.0000000000002672","journal":"Neurology","n_participants":null,"pmid":"27164711","source_url":"https://pubmed.ncbi.nlm.nih.gov/27164711/","study_design":"cross-sectional","title":"Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease","title_match":false,"year":2016},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/cognitive-decline-in-a-colombian-kindred-with-autosomal-dominant-26902171","doi":"10.1001/jamaneurol.2015.4851","journal":"JAMA neurology","n_participants":493,"pmid":"26902171","source_url":"https://pubmed.ncbi.nlm.nih.gov/26902171/","study_design":"cohort study","title":"Cognitive Decline in a Colombian Kindred With Autosomal Dominant Alzheimer Disease: A Retrospective Cohort Study","title_match":true,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/amyloid-pathology-and-apoe-genotype-modulate-retinoid-x-receptor-25217640","doi":"10.1074/jbc.m114.600833","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"25217640","source_url":"https://pubmed.ncbi.nlm.nih.gov/25217640/","study_design":null,"title":"Amyloid-\u03b2 pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo","title_match":false,"year":2014},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/age-of-onset-in-huntington-disease-sex-specific-influence-of-10051007","doi":null,"journal":"Journal of medical genetics","n_participants":null,"pmid":"10051007","source_url":"https://pubmed.ncbi.nlm.nih.gov/10051007/","study_design":null,"title":"Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length","title_match":false,"year":1999},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe-apolipoprotein-e-in-brain-pericytes-regulates-endothelial-31665905","doi":"10.1161/atvbaha.119.313169","journal":"Arteriosclerosis, thrombosis, and vascular biology","n_participants":null,"pmid":"31665905","source_url":"https://pubmed.ncbi.nlm.nih.gov/31665905/","study_design":null,"title":"ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components","title_match":false,"year":2020},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/association-of-alzheimer-s-disease-gwas-loci-with-mri-markers-of-25670335","doi":"10.1016/j.neurobiolaging.2014.12.028","journal":"Neurobiology of aging","n_participants":8175,"pmid":"25670335","source_url":"https://pubmed.ncbi.nlm.nih.gov/25670335/","study_design":"meta-analysis","title":"Association of Alzheimer's disease GWAS loci with MRI markers of brain aging","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/combined-liver-x-receptor-peroxisome-proliferator-activated-receptor-26163517","doi":"10.1074/jbc.m115.652008","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"26163517","source_url":"https://pubmed.ncbi.nlm.nih.gov/26163517/","study_design":null,"title":"Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor \u03b3 Agonist Treatment Reduces Amyloid \u03b2 Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice","title_match":true,"year":2015},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/processing-of-the-synaptic-cell-adhesion-molecule-neurexin-3beta-by-21084300","doi":"10.1074/jbc.m110.142521","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"21084300","source_url":"https://pubmed.ncbi.nlm.nih.gov/21084300/","study_design":null,"title":"Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases","title_match":false,"year":2011},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon-4-allele-in-alzheimer-s-disease-and-vascular-7951679","doi":"10.1159/000106730","journal":"Dementia (Basel, Switzerland)","n_participants":null,"pmid":"7951679","source_url":"https://pubmed.ncbi.nlm.nih.gov/7951679/","study_design":null,"title":"Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia","title_match":false,"year":1994},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/eeg-alterations-in-non-demented-individuals-related-to-apolipoprotein-17293007","doi":"10.1016/j.neurobiolaging.2006.12.019","journal":"Neurobiology of aging","n_participants":145,"pmid":"17293007","source_url":"https://pubmed.ncbi.nlm.nih.gov/17293007/","study_design":null,"title":"EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/both-common-variations-and-rare-non-synonymous-substitutions-and-22248099","doi":"10.1186/1750-1326-7-3","journal":"Molecular neurodegeneration","n_participants":1930,"pmid":"22248099","source_url":"https://pubmed.ncbi.nlm.nih.gov/22248099/","study_design":"meta-analysis","title":"Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/fine-mapping-of-the-chromosome-12-late-onset-alzheimer-disease-locus-10712207","doi":"10.1086/302828","journal":"American journal of human genetics","n_participants":null,"pmid":"10712207","source_url":"https://pubmed.ncbi.nlm.nih.gov/10712207/","study_design":null,"title":"Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity","title_match":false,"year":2000},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/obesity-accelerates-alzheimer-related-pathology-in-i-apoe4-i-but-not-28612048","doi":"10.1523/eneuro.0077-17.2017","journal":"eNeuro","n_participants":null,"pmid":"28612048","source_url":"https://pubmed.ncbi.nlm.nih.gov/28612048/","study_design":null,"title":"Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/specificity-of-brain-activation-patterns-in-people-at-genetic-risk-11790634","doi":"10.1097/00019442-200201000-00006","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":25,"pmid":"11790634","source_url":"https://pubmed.ncbi.nlm.nih.gov/11790634/","study_design":null,"title":"Specificity of brain activation patterns in people at genetic risk for Alzheimer disease","title_match":true,"year":2002},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/cognitive-function-over-time-in-the-alzheimer-s-disease-anti-18474729","doi":"10.1001/archneur.2008.65.7.nct70006","journal":"Archives of neurology","n_participants":null,"pmid":"18474729","source_url":"https://pubmed.ncbi.nlm.nih.gov/18474729/","study_design":"longitudinal study","title":"Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib","title_match":false,"year":2008},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/naproxen-and-celecoxib-do-not-prevent-ad-in-early-results-from-a-17460158","doi":"10.1212/01.wnl.0000260269.93245.d2","journal":"Neurology","n_participants":null,"pmid":"17460158","source_url":"https://pubmed.ncbi.nlm.nih.gov/17460158/","study_design":null,"title":"Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial","title_match":false,"year":2007},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/intrepad-a-randomized-trial-of-naproxen-to-slow-progress-of-30952794","doi":"10.1212/wnl.0000000000007232","journal":"Neurology","n_participants":195,"pmid":"30952794","source_url":"https://pubmed.ncbi.nlm.nih.gov/30952794/","study_design":null,"title":"INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease","title_match":false,"year":2019},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/celecoxib-or-naproxen-treatment-does-not-benefit-depressive-symptoms-21775876","doi":"10.1097/jgp.0b013e318227f4da","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":2528,"pmid":"21775876","source_url":"https://pubmed.ncbi.nlm.nih.gov/21775876/","study_design":"longitudinal study","title":"Celecoxib or naproxen treatment does not benefit depressive symptoms in persons age 70 and older:  findings from a randomized controlled trial","title_match":false,"year":2012},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-anti-inflammatory-prevention-trial-design-methods-19328435","doi":"10.1016/j.jalz.2008.09.004","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"19328435","source_url":"https://pubmed.ncbi.nlm.nih.gov/19328435/","study_design":null,"title":"Alzheimer's Disease Anti-inflammatory Prevention Trial: design, methods, and baseline results","title_match":false,"year":2009},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/a-randomized-controlled-trial-of-disclosing-genetic-risk-information-28726810","doi":"10.1038/gim.2017.103","journal":"Genetics in medicine : official journal of the American College of Medical Genetics","n_participants":257,"pmid":"28726810","source_url":"https://pubmed.ncbi.nlm.nih.gov/28726810/","study_design":null,"title":"A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone","title_match":true,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genetic-susceptibility-testing-versus-family-history-based-risk-15654228","doi":"10.1097/01.gim.0000151157.13716.6c","journal":"Genetics in medicine : official journal of the American College of Medical Genetics","n_participants":30,"pmid":"15654228","source_url":"https://pubmed.ncbi.nlm.nih.gov/15654228/","study_design":null,"title":"Genetic susceptibility testing versus family history-based risk assessment: Impact on perceived risk of Alzheimer disease","title_match":true,"year":2005},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/a-phase-i-study-to-assess-the-effect-of-speed-of-injection-on-pain-31883703","doi":"10.1016/j.clinthera.2019.11.015","journal":"Clinical therapeutics","n_participants":null,"pmid":"31883703","source_url":"https://pubmed.ncbi.nlm.nih.gov/31883703/","study_design":"open-label trial","title":"A Phase I Study to Assess the Effect of Speed of Injection on Pain, Tolerability, and Pharmacokinetics After High-volume Subcutaneous Administration of Gantenerumab in Healthy Volunteers","title_match":false,"year":2020},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/slowing-cognitive-decline-in-major-depressive-disorder-and-mild-39476073","doi":"10.1001/jamapsychiatry.2024.3241","journal":"JAMA psychiatry","n_participants":null,"pmid":"39476073","source_url":"https://pubmed.ncbi.nlm.nih.gov/39476073/","study_design":null,"title":"Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/disclosing-pleiotropic-effects-during-genetic-risk-assessment-for-26810768","doi":"10.7326/m15-0187","journal":"Annals of internal medicine","n_participants":null,"pmid":"26810768","source_url":"https://pubmed.ncbi.nlm.nih.gov/26810768/","study_design":null,"title":"Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial","title_match":true,"year":2016},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/incorporating-ethnicity-into-genetic-risk-assessment-for-alzheimer-18344711","doi":"10.1097/gim.0b013e318164e4cf","journal":"Genetics in medicine : official journal of the American College of Medical Genetics","n_participants":null,"pmid":"18344711","source_url":"https://pubmed.ncbi.nlm.nih.gov/18344711/","study_design":null,"title":"Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience","title_match":true,"year":2008},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/effectiveness-of-a-condensed-protocol-for-disclosing-apoe-genotype-22498844","doi":"10.1038/gim.2012.37","journal":"Genetics in medicine : official journal of the American College of Medical Genetics","n_participants":280,"pmid":"22498844","source_url":"https://pubmed.ncbi.nlm.nih.gov/22498844/","study_design":null,"title":"Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/parental-history-of-memory-impairment-and-amyloid-in-cognitively-38884955","doi":"10.1001/jamaneurol.2024.1763","journal":"JAMA neurology","n_participants":455,"pmid":"38884955","source_url":"https://pubmed.ncbi.nlm.nih.gov/38884955/","study_design":"cross-sectional","title":"Parental History of Memory Impairment and \u03b2-Amyloid in Cognitively Unimpaired Older Adults","title_match":false,"year":2024},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/validity-and-power-of-minimization-algorithm-in-longitudinal-analysis-29250611","doi":"10.1080/24709360.2017.1331822","journal":"Biostatistics & epidemiology","n_participants":null,"pmid":"29250611","source_url":"https://pubmed.ncbi.nlm.nih.gov/29250611/","study_design":"longitudinal study","title":"Validity and power of minimization algorithm in longitudinal analysis of clinical trials","title_match":false,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/pulse-pressure-as-a-predictor-of-alzheimer-s-disease-biomarkers-and-40908201","doi":"10.1016/j.tjpad.2025.100363","journal":"The journal of prevention of Alzheimer's disease","n_participants":1690,"pmid":"40908201","source_url":"https://pubmed.ncbi.nlm.nih.gov/40908201/","study_design":"cohort study","title":"Pulse pressure as a predictor of Alzheimer's disease biomarkers and cognitive decline: The moderating role of APOE \u03b54","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/cardiovascular-risk-and-memory-in-non-demented-elderly-women-18805604","doi":"10.1016/j.neurobiolaging.2008.08.007","journal":"Neurobiology of aging","n_participants":375,"pmid":"18805604","source_url":"https://pubmed.ncbi.nlm.nih.gov/18805604/","study_design":null,"title":"Cardiovascular risk and memory in non-demented elderly women","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-genotype-disclosure-and-lifestyle-advice-in-a-randomized-33188400","doi":"10.1093/jn/nxaa316","journal":"The Journal of nutrition","n_participants":33,"pmid":"33188400","source_url":"https://pubmed.ncbi.nlm.nih.gov/33188400/","study_design":null,"title":"APOE Genotype Disclosure and Lifestyle Advice in a Randomized Intervention Study with Finnish Participants","title_match":false,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/effects-of-exercise-and-intensive-vascular-risk-reduction-on-41870419","doi":"10.1001/jamaneurol.2026.0359","journal":"JAMA neurology","n_participants":3290,"pmid":"41870419","source_url":"https://pubmed.ncbi.nlm.nih.gov/41870419/","study_design":null,"title":"Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults: A Randomized Clinical Trial","title_match":false,"year":2026},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-4-dependent-associations-between-carotenoids-and-40876538","doi":"10.1016/j.ajcnut.2025.08.012","journal":"The American journal of clinical nutrition","n_participants":442,"pmid":"40876538","source_url":"https://pubmed.ncbi.nlm.nih.gov/40876538/","study_design":"randomized controlled trial","title":"Apolipoprotein E \u03b54-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-33667416","doi":"10.1016/s0140-6736(20)32205-4","journal":"Lancet (London, England)","n_participants":null,"pmid":"33667416","source_url":"https://pubmed.ncbi.nlm.nih.gov/33667416/","study_design":null,"title":"Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/limbic-predominant-age-related-tdp-43-encephalopathy-late-consensus-31039256","doi":"10.1093/brain/awz099","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"31039256","source_url":"https://pubmed.ncbi.nlm.nih.gov/31039256/","study_design":null,"title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report","title_match":false,"year":2019},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-and-vascular-dementia-in-developing-countries-18667359","doi":"10.1016/s1474-4422(08)70169-8","journal":"The Lancet. Neurology","n_participants":null,"pmid":"18667359","source_url":"https://pubmed.ncbi.nlm.nih.gov/18667359/","study_design":null,"title":"Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors","title_match":false,"year":2008},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/subcortical-ischaemic-vascular-dementia-12849365","doi":"10.1016/s1474-4422(02)00190-4","journal":"The Lancet. Neurology","n_participants":null,"pmid":"12849365","source_url":"https://pubmed.ncbi.nlm.nih.gov/12849365/","study_design":null,"title":"Subcortical ischaemic vascular dementia","title_match":false,"year":2002},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/association-of-lifestyle-and-genetic-risk-with-incidence-of-dementia-31302669","doi":"10.1001/jama.2019.9879","journal":"JAMA","n_participants":383,"pmid":"31302669","source_url":"https://pubmed.ncbi.nlm.nih.gov/31302669/","study_design":"cohort study","title":"Association of Lifestyle and Genetic Risk With Incidence of Dementia","title_match":true,"year":2019},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/gwas-on-family-history-of-alzheimer-s-disease-29777097","doi":"10.1038/s41398-018-0150-6","journal":"Translational psychiatry","n_participants":74046,"pmid":"29777097","source_url":"https://pubmed.ncbi.nlm.nih.gov/29777097/","study_design":"meta-analysis","title":"GWAS on family history of Alzheimer's disease","title_match":true,"year":2018},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-improves-cognition-the-predimed-navarra-randomised-23670794","doi":"10.1136/jnnp-2012-304792","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":522,"pmid":"23670794","source_url":"https://pubmed.ncbi.nlm.nih.gov/23670794/","study_design":null,"title":"Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-neuropathology-of-chronic-traumatic-encephalopathy-25904048","doi":"10.1111/bpa.12248","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"25904048","source_url":"https://pubmed.ncbi.nlm.nih.gov/25904048/","study_design":null,"title":"The neuropathology of chronic traumatic encephalopathy","title_match":false,"year":2015},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/neurovascular-dysfunction-and-neurodegeneration-in-dementia-and-26705676","doi":"10.1016/j.bbadis.2015.12.016","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"26705676","source_url":"https://pubmed.ncbi.nlm.nih.gov/26705676/","study_design":null,"title":"Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/stroke-injury-cognitive-impairment-and-vascular-dementia-26806700","doi":"10.1016/j.bbadis.2016.01.015","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"26806700","source_url":"https://pubmed.ncbi.nlm.nih.gov/26806700/","study_design":null,"title":"Stroke injury, cognitive impairment and vascular dementia","title_match":false,"year":2016},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/brain-imaging-and-fluid-biomarker-analysis-in-young-adults-at-genetic-23137948","doi":"10.1016/s1474-4422(12)70228-4","journal":"The Lancet. Neurology","n_participants":44,"pmid":"23137948","source_url":"https://pubmed.ncbi.nlm.nih.gov/23137948/","study_design":null,"title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study","title_match":true,"year":2012},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/update-on-alzheimer-s-disease-therapy-and-prevention-strategies-28099083","doi":"10.1146/annurev-med-042915-103753","journal":"Annual review of medicine","n_participants":null,"pmid":"28099083","source_url":"https://pubmed.ncbi.nlm.nih.gov/28099083/","study_design":null,"title":"Update on Alzheimer's Disease Therapy and Prevention Strategies","title_match":false,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-associated-with-down-syndrome-a-genetic-form-of-34687637","doi":"10.1016/s1474-4422(21)00245-3","journal":"The Lancet. Neurology","n_participants":null,"pmid":"34687637","source_url":"https://pubmed.ncbi.nlm.nih.gov/34687637/","study_design":null,"title":"Alzheimer's disease associated with Down syndrome: a genetic form of dementia","title_match":false,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/risk-factors-associated-with-the-onset-and-progression-of-alzheimer-s-28363508","doi":"10.1016/j.neuro.2017.03.006","journal":"Neurotoxicology","n_participants":65,"pmid":"28363508","source_url":"https://pubmed.ncbi.nlm.nih.gov/28363508/","study_design":"systematic review","title":"Risk factors associated with the onset and progression of Alzheimer's disease: A systematic review of the evidence","title_match":false,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/hearing-loss-as-a-risk-factor-for-dementia-a-systematic-review-28894825","doi":"10.1002/lio2.65","journal":"Laryngoscope investigative otolaryngology","n_participants":null,"pmid":"28894825","source_url":"https://pubmed.ncbi.nlm.nih.gov/28894825/","study_design":"systematic review","title":"Hearing loss as a risk factor for dementia: A systematic review","title_match":false,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/wine-consumption-and-dementia-in-the-elderly-a-prospective-community-9296132","doi":null,"journal":"Revue neurologique","n_participants":3777,"pmid":"9296132","source_url":"https://pubmed.ncbi.nlm.nih.gov/9296132/","study_design":null,"title":"Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area","title_match":false,"year":1997},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/risk-factors-for-neurodegeneration-in-idiopathic-rapid-eye-movement-25767079","doi":"10.1002/ana.24385","journal":"Annals of neurology","n_participants":305,"pmid":"25767079","source_url":"https://pubmed.ncbi.nlm.nih.gov/25767079/","study_design":null,"title":"Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/does-caffeine-intake-protect-from-alzheimer-s-disease-12099922","doi":"10.1046/j.1468-1331.2002.00421.x","journal":"European journal of neurology","n_participants":54,"pmid":"12099922","source_url":"https://pubmed.ncbi.nlm.nih.gov/12099922/","study_design":"case-control study","title":"Does caffeine intake protect from Alzheimer's disease?","title_match":false,"year":2002},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/advances-in-the-prevention-of-alzheimer-s-disease-and-dementia-24605807","doi":"10.1111/joim.12178","journal":"Journal of internal medicine","n_participants":null,"pmid":"24605807","source_url":"https://pubmed.ncbi.nlm.nih.gov/24605807/","study_design":null,"title":"Advances in the prevention of Alzheimer's disease and dementia","title_match":false,"year":2014},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/florbetapir-pet-analysis-of-amyloid-deposition-in-the-presenilin-1-23137949","doi":"10.1016/s1474-4422(12)70227-2","journal":"The Lancet. Neurology","n_participants":null,"pmid":"23137949","source_url":"https://pubmed.ncbi.nlm.nih.gov/23137949/","study_design":"cross-sectional","title":"Florbetapir PET analysis of amyloid-\u03b2 deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study","title_match":true,"year":2012},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/genetic-predisposition-modifiable-risk-factor-profile-and-long-term-31451782","doi":"10.1038/s41591-019-0547-7","journal":"Nature medicine","n_participants":6352,"pmid":"31451782","source_url":"https://pubmed.ncbi.nlm.nih.gov/31451782/","study_design":null,"title":"Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population","title_match":false,"year":2019},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/virgin-olive-oil-supplementation-and-long-term-cognition-the-predimed-23732551","doi":"10.1007/s12603-013-0027-6","journal":"The journal of nutrition, health & aging","n_participants":285,"pmid":"23732551","source_url":"https://pubmed.ncbi.nlm.nih.gov/23732551/","study_design":"randomized controlled trial","title":"Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial","title_match":false,"year":2013},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/longitudinal-plasma-metabolomics-of-aging-and-sex-30799310","doi":"10.18632/aging.101837","journal":"Aging","n_participants":1212,"pmid":"30799310","source_url":"https://pubmed.ncbi.nlm.nih.gov/30799310/","study_design":"longitudinal study","title":"Longitudinal plasma metabolomics of aging and sex","title_match":false,"year":2019},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/designing-prevention-programmes-to-reduce-incidence-of-dementia-20688841","doi":"10.1136/bmj.c3885","journal":"BMJ (Clinical research ed.)","n_participants":1433,"pmid":"20688841","source_url":"https://pubmed.ncbi.nlm.nih.gov/20688841/","study_design":"cohort study","title":"Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/white-matter-changes-in-dementia-role-of-impaired-drainage-of-25521178","doi":"10.1111/bpa.12218","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"25521178","source_url":"https://pubmed.ncbi.nlm.nih.gov/25521178/","study_design":null,"title":"White matter changes in dementia: role of impaired drainage of interstitial fluid","title_match":false,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/future-directions-in-alzheimer-s-disease-from-risk-factors-to-24418410","doi":"10.1016/j.bcp.2014.01.003","journal":"Biochemical pharmacology","n_participants":null,"pmid":"24418410","source_url":"https://pubmed.ncbi.nlm.nih.gov/24418410/","study_design":null,"title":"Future directions in Alzheimer's disease from risk factors to prevention","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/gwas-identifies-44-independent-associated-genomic-loci-for-self-31564434","doi":"10.1016/j.ajhg.2019.09.008","journal":"American journal of human genetics","n_participants":null,"pmid":"31564434","source_url":"https://pubmed.ncbi.nlm.nih.gov/31564434/","study_design":null,"title":"GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cardiovascular-and-cerebrovascular-events-in-the-randomized-17111043","doi":"10.1371/journal.pctr.0010033","journal":"PLoS clinical trials","n_participants":2528,"pmid":"17111043","source_url":"https://pubmed.ncbi.nlm.nih.gov/17111043/","study_design":null,"title":"Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)","title_match":false,"year":2006},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/high-fat-diet-induced-deregulation-of-hippocampal-insulin-signaling-26003667","doi":"10.1016/j.bbadis.2015.05.004","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"26003667","source_url":"https://pubmed.ncbi.nlm.nih.gov/26003667/","study_design":null,"title":"High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents","title_match":false,"year":2015},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/rationale-and-design-of-the-hamburg-city-health-study-31705407","doi":"10.1007/s10654-019-00577-4","journal":"European journal of epidemiology","n_participants":45000,"pmid":"31705407","source_url":"https://pubmed.ncbi.nlm.nih.gov/31705407/","study_design":"cohort study","title":"Rationale and Design of the Hamburg City Health Study","title_match":false,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/translating-genetic-risk-of-alzheimer-s-disease-into-mechanistic-33004512","doi":"10.1126/science.abb8575","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"33004512","source_url":"https://pubmed.ncbi.nlm.nih.gov/33004512/","study_design":null,"title":"Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets","title_match":true,"year":2020},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/frailty-lifestyle-genetics-and-dementia-risk-34933996","doi":"10.1136/jnnp-2021-327396","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":1762,"pmid":"34933996","source_url":"https://pubmed.ncbi.nlm.nih.gov/34933996/","study_design":null,"title":"Frailty, lifestyle, genetics and dementia risk","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/effects-of-aerobic-exercise-training-on-systemic-biomarkers-and-34093436","doi":"10.3389/fendo.2021.660181","journal":"Frontiers in endocrinology","n_participants":null,"pmid":"34093436","source_url":"https://pubmed.ncbi.nlm.nih.gov/34093436/","study_design":null,"title":"Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/the-neuropathological-diagnosis-of-alzheimer-s-disease-31375134","doi":"10.1186/s13024-019-0333-5","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31375134","source_url":"https://pubmed.ncbi.nlm.nih.gov/31375134/","study_design":null,"title":"The neuropathological diagnosis of Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-16876668","doi":"10.1016/s0140-6736(06)69113-7","journal":"Lancet (London, England)","n_participants":null,"pmid":"16876668","source_url":"https://pubmed.ncbi.nlm.nih.gov/16876668/","study_design":null,"title":"Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/camdex-a-standardised-instrument-for-the-diagnosis-of-mental-disorder-3790869","doi":"10.1192/bjp.149.6.698","journal":"The British journal of psychiatry : the journal of mental science","n_participants":null,"pmid":"3790869","source_url":"https://pubmed.ncbi.nlm.nih.gov/3790869/","study_design":null,"title":"CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia","title_match":false,"year":1986},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/amyotrophic-lateral-sclerosis-a-clinical-review-32526057","doi":"10.1111/ene.14393","journal":"European journal of neurology","n_participants":null,"pmid":"32526057","source_url":"https://pubmed.ncbi.nlm.nih.gov/32526057/","study_design":null,"title":"Amyotrophic lateral sclerosis: a clinical review","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/neuropathologic-diagnostic-and-nosologic-criteria-for-frontotemporal-17579875","doi":"10.1007/s00401-007-0237-2","journal":"Acta neuropathologica","n_participants":null,"pmid":"17579875","source_url":"https://pubmed.ncbi.nlm.nih.gov/17579875/","study_design":null,"title":"Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration","title_match":false,"year":2007},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/structure-based-classification-of-tauopathies-34588692","doi":"10.1038/s41586-021-03911-7","journal":"Nature","n_participants":null,"pmid":"34588692","source_url":"https://pubmed.ncbi.nlm.nih.gov/34588692/","study_design":null,"title":"Structure-based classification of tauopathies","title_match":false,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/huntington-s-disease-a-clinical-review-21171977","doi":"10.1186/1750-1172-5-40","journal":"Orphanet journal of rare diseases","n_participants":null,"pmid":"21171977","source_url":"https://pubmed.ncbi.nlm.nih.gov/21171977/","study_design":null,"title":"Huntington's disease: a clinical review","title_match":false,"year":2010},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-overlap-of-amyotrophic-lateral-sclerosis-and-frontotemporal-12370467","doi":"10.1212/wnl.59.7.1077","journal":"Neurology","n_participants":36,"pmid":"12370467","source_url":"https://pubmed.ncbi.nlm.nih.gov/12370467/","study_design":null,"title":"The overlap of amyotrophic lateral sclerosis and frontotemporal dementia","title_match":false,"year":2002},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-diagnosis-and-management-of-amyotrophic-lateral-sclerosis-21989247","doi":"10.1038/nrneurol.2011.153","journal":"Nature reviews. Neurology","n_participants":100000,"pmid":"21989247","source_url":"https://pubmed.ncbi.nlm.nih.gov/21989247/","study_design":null,"title":"Clinical diagnosis and management of amyotrophic lateral sclerosis","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-diagnosis-of-young-onset-dementia-20650401","doi":"10.1016/s1474-4422(10)70159-9","journal":"The Lancet. Neurology","n_participants":null,"pmid":"20650401","source_url":"https://pubmed.ncbi.nlm.nih.gov/20650401/","study_design":null,"title":"The diagnosis of young-onset dementia","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/clinical-genetic-and-pathological-heterogeneity-of-frontotemporal-20971753","doi":"10.1136/jnnp.2010.212225","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"20971753","source_url":"https://pubmed.ncbi.nlm.nih.gov/20971753/","study_design":null,"title":"Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review","title_match":false,"year":2011},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-phenotypic-spectrum-of-cadasil-clinical-findings-in-102-cases-9818928","doi":"10.1002/ana.410440506","journal":"Annals of neurology","n_participants":null,"pmid":"9818928","source_url":"https://pubmed.ncbi.nlm.nih.gov/9818928/","study_design":null,"title":"The phenotypic spectrum of CADASIL: clinical findings in 102 cases","title_match":false,"year":1998},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-and-cerebrospinal-fluid-levels-of-amyloid-beta-proteins-1-40-10634455","doi":"10.1001/archneur.57.1.100","journal":"Archives of neurology","n_participants":78,"pmid":"10634455","source_url":"https://pubmed.ncbi.nlm.nih.gov/10634455/","study_design":null,"title":"Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease","title_match":false,"year":2000},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinical-spectrum-of-cadasil-a-study-of-7-families-cerebral-autosomal-7564728","doi":"10.1016/s0140-6736(95)91557-5","journal":"Lancet (London, England)","n_participants":148,"pmid":"7564728","source_url":"https://pubmed.ncbi.nlm.nih.gov/7564728/","study_design":null,"title":"Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","title_match":true,"year":1995},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-heritability-and-genetics-of-frontotemporal-lobar-degeneration-19884572","doi":"10.1212/wnl.0b013e3181bf997a","journal":"Neurology","n_participants":225,"pmid":"19884572","source_url":"https://pubmed.ncbi.nlm.nih.gov/19884572/","study_design":null,"title":"The heritability and genetics of frontotemporal lobar degeneration","title_match":true,"year":2009},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/clinicopathological-features-of-adult-onset-neuronal-intranuclear-27797808","doi":"10.1093/brain/aww249","journal":"Brain : a journal of neurology","n_participants":57,"pmid":"27797808","source_url":"https://pubmed.ncbi.nlm.nih.gov/27797808/","study_design":null,"title":"Clinicopathological features of adult-onset neuronal intranuclear inclusion disease","title_match":false,"year":2016},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/delirium-accelerates-cognitive-decline-in-alzheimer-disease-19414723","doi":"10.1212/wnl.0b013e3181a4129a","journal":"Neurology","n_participants":72,"pmid":"19414723","source_url":"https://pubmed.ncbi.nlm.nih.gov/19414723/","study_design":"prospective cohort","title":"Delirium accelerates cognitive decline in Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/neuropathological-diagnosis-of-vascular-cognitive-impairment-and-27062261","doi":"10.1007/s00401-016-1571-z","journal":"Acta neuropathologica","n_participants":null,"pmid":"27062261","source_url":"https://pubmed.ncbi.nlm.nih.gov/27062261/","study_design":null,"title":"Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/locus-specific-mutation-databases-for-neurodegenerative-brain-diseases-22581678","doi":"10.1002/humu.22117","journal":"Human mutation","n_participants":null,"pmid":"22581678","source_url":"https://pubmed.ncbi.nlm.nih.gov/22581678/","study_design":null,"title":"Locus-specific mutation databases for neurodegenerative brain diseases","title_match":false,"year":2012},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/an-atlas-of-cortical-circular-rna-expression-in-alzheimer-disease-31591557","doi":"10.1038/s41593-019-0501-5","journal":"Nature neuroscience","n_participants":null,"pmid":"31591557","source_url":"https://pubmed.ncbi.nlm.nih.gov/31591557/","study_design":null,"title":"An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/frontotemporal-lobar-degeneration-epidemiology-pathophysiology-20369906","doi":"10.2165/11533100-000000000-00000","journal":"CNS drugs","n_participants":null,"pmid":"20369906","source_url":"https://pubmed.ncbi.nlm.nih.gov/20369906/","study_design":null,"title":"Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management","title_match":false,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/detection-of-14-3-3-protein-in-the-cerebrospinal-fluid-supports-the-9450766","doi":"10.1002/ana.410430109","journal":"Annals of neurology","n_participants":null,"pmid":"9450766","source_url":"https://pubmed.ncbi.nlm.nih.gov/9450766/","study_design":null,"title":"Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease","title_match":false,"year":1998},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/drugs-with-anticholinergic-properties-cognitive-decline-and-dementia-19636034","doi":"10.1001/archinternmed.2009.229","journal":"Archives of internal medicine","n_participants":null,"pmid":"19636034","source_url":"https://pubmed.ncbi.nlm.nih.gov/19636034/","study_design":null,"title":"Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study","title_match":false,"year":2009},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/spatial-patterns-of-neuroimaging-biomarker-change-in-individuals-from-29397305","doi":"10.1016/s1474-4422(18)30028-0","journal":"The Lancet. Neurology","n_participants":346,"pmid":"29397305","source_url":"https://pubmed.ncbi.nlm.nih.gov/29397305/","study_design":"longitudinal study","title":"Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study","title_match":true,"year":2018},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/white-matter-hyperintensities-are-a-core-feature-of-alzheimer-s-27016429","doi":"10.1002/ana.24647","journal":"Annals of neurology","n_participants":299,"pmid":"27016429","source_url":"https://pubmed.ncbi.nlm.nih.gov/27016429/","study_design":null,"title":"White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network","title_match":true,"year":2016},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/longitudinal-change-in-csf-biomarkers-in-autosomal-dominant-alzheimer-24598588","doi":"10.1126/scitranslmed.3007901","journal":"Science translational medicine","n_participants":null,"pmid":"24598588","source_url":"https://pubmed.ncbi.nlm.nih.gov/24598588/","study_design":"cross-sectional","title":"Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/brain-connectivity-in-neurodegenerative-diseases-from-phenotype-to-25287597","doi":"10.1038/nrneurol.2014.178","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"25287597","source_url":"https://pubmed.ncbi.nlm.nih.gov/25287597/","study_design":null,"title":"Brain connectivity in neurodegenerative diseases--from phenotype to proteinopathy","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mitochondria-associated-er-membranes-in-alzheimer-disease-22922446","doi":"10.1016/j.mcn.2012.07.011","journal":"Molecular and cellular neurosciences","n_participants":null,"pmid":"22922446","source_url":"https://pubmed.ncbi.nlm.nih.gov/22922446/","study_design":null,"title":"Mitochondria-associated ER membranes in Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/vascular-pathologies-and-cognition-in-a-population-based-cohort-of-15537512","doi":"10.1016/j.jns.2004.09.004","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"15537512","source_url":"https://pubmed.ncbi.nlm.nih.gov/15537512/","study_design":"longitudinal study","title":"Vascular pathologies and cognition in a population-based cohort of elderly people","title_match":false,"year":2004},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tau-pet-in-autosomal-dominant-alzheimer-s-disease-relationship-with-30753379","doi":"10.1093/brain/awz019","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"30753379","source_url":"https://pubmed.ncbi.nlm.nih.gov/30753379/","study_design":"cross-sectional","title":"Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers","title_match":true,"year":2019},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-between-amyloid-and-tau-accumulation-in-young-adults-with-29435558","doi":"10.1001/jamaneurol.2017.4907","journal":"JAMA neurology","n_participants":24,"pmid":"29435558","source_url":"https://pubmed.ncbi.nlm.nih.gov/29435558/","study_design":"cross-sectional","title":"Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease","title_match":true,"year":2018},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/soluble-trem2-in-csf-and-its-association-with-other-biomarkers-and-35305339","doi":"10.1016/s1474-4422(22)00027-8","journal":"The Lancet. Neurology","n_participants":155,"pmid":"35305339","source_url":"https://pubmed.ncbi.nlm.nih.gov/35305339/","study_design":"longitudinal study","title":"Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study","title_match":false,"year":2022},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/impaired-default-network-functional-connectivity-in-autosomal-23884042","doi":"10.1212/wnl.0b013e3182a1aafe","journal":"Neurology","n_participants":null,"pmid":"23884042","source_url":"https://pubmed.ncbi.nlm.nih.gov/23884042/","study_design":"cross-sectional","title":"Impaired default network functional connectivity in autosomal dominant Alzheimer disease","title_match":true,"year":2013},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/low-pib-pet-retention-in-presence-of-pathologic-csf-biomarkers-in-22700814","doi":"10.1212/wnl.0b013e31825fdf18","journal":"Neurology","n_participants":null,"pmid":"22700814","source_url":"https://pubmed.ncbi.nlm.nih.gov/22700814/","study_design":null,"title":"Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers","title_match":true,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/differential-regional-atrophy-of-the-cingulate-gyrus-in-alzheimer-16400164","doi":"10.1093/cercor/bhj105","journal":"Cerebral cortex (New York, N.Y. : 1991)","n_participants":null,"pmid":"16400164","source_url":"https://pubmed.ncbi.nlm.nih.gov/16400164/","study_design":null,"title":"Differential regional atrophy of the cingulate gyrus in Alzheimer disease: a volumetric MRI study","title_match":false,"year":2006},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/diffusion-magnetic-resonance-histograms-as-a-surrogate-marker-and-16269644","doi":"10.1161/01.str.0000189696.70989.a4","journal":"Stroke","n_participants":null,"pmid":"16269644","source_url":"https://pubmed.ncbi.nlm.nih.gov/16269644/","study_design":"longitudinal study","title":"Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study","title_match":false,"year":2005},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/functional-connectivity-in-autosomal-dominant-and-late-onset-25069482","doi":"10.1001/jamaneurol.2014.1654","journal":"JAMA neurology","n_participants":79,"pmid":"25069482","source_url":"https://pubmed.ncbi.nlm.nih.gov/25069482/","study_design":"cross-sectional","title":"Functional connectivity in autosomal dominant and late-onset Alzheimer disease","title_match":true,"year":2014},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/correlation-of-in-vivo-18f-flortaucipir-with-postmortem-alzheimer-30508025","doi":"10.1001/jamaneurol.2018.3692","journal":"JAMA neurology","n_participants":null,"pmid":"30508025","source_url":"https://pubmed.ncbi.nlm.nih.gov/30508025/","study_design":null,"title":"Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology","title_match":false,"year":2019},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/etiology-of-white-matter-hyperintensities-in-autosomal-dominant-and-37843849","doi":"10.1001/jamaneurol.2023.3618","journal":"JAMA neurology","n_participants":1141,"pmid":"37843849","source_url":"https://pubmed.ncbi.nlm.nih.gov/37843849/","study_design":"cohort study","title":"Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-pattern-of-atrophy-in-familial-alzheimer-disease-volumetric-mri-24049139","doi":"10.1212/wnl.0b013e3182a841c6","journal":"Neurology","n_participants":192,"pmid":"24049139","source_url":"https://pubmed.ncbi.nlm.nih.gov/24049139/","study_design":"cross-sectional","title":"The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study","title_match":true,"year":2013},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/sustainable-method-for-alzheimer-dementia-prediction-in-mild-30014515","doi":"10.1002/ana.25289","journal":"Annals of neurology","n_participants":97,"pmid":"30014515","source_url":"https://pubmed.ncbi.nlm.nih.gov/30014515/","study_design":null,"title":"Sustainable method for Alzheimer dementia prediction in mild cognitive impairment: Electroencephalographic connectivity and graph theory combined with apolipoprotein E","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/predicting-the-rate-of-cognitive-decline-in-aging-and-early-alzheimer-15249619","doi":"10.1212/01.wnl.0000132520.69612.ab","journal":"Neurology","n_participants":null,"pmid":"15249619","source_url":"https://pubmed.ncbi.nlm.nih.gov/15249619/","study_design":"longitudinal study","title":"Predicting the rate of cognitive decline in aging and early Alzheimer disease","title_match":false,"year":2004},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/cortical-microstructural-correlates-of-astrocytosis-in-autosomal-32291295","doi":"10.1212/wnl.0000000000009405","journal":"Neurology","n_participants":31,"pmid":"32291295","source_url":"https://pubmed.ncbi.nlm.nih.gov/32291295/","study_design":null,"title":"Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease","title_match":false,"year":2020},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/presymptomatic-cortical-thinning-in-familial-alzheimer-disease-a-27733562","doi":"10.1212/wnl.0000000000003322","journal":"Neurology","n_participants":43,"pmid":"27733562","source_url":"https://pubmed.ncbi.nlm.nih.gov/27733562/","study_design":"longitudinal study","title":"Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study","title_match":true,"year":2016},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/catenin-is-genetically-and-biologically-associated-with-cortical-22984439","doi":"10.1371/journal.pone.0043728","journal":"PloS one","n_participants":null,"pmid":"22984439","source_url":"https://pubmed.ncbi.nlm.nih.gov/22984439/","study_design":null,"title":"\u03b4-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes","title_match":false,"year":2012},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/association-of-parental-dementia-with-cognitive-and-brain-mri-20007524","doi":"10.1212/wnl.0b013e3181c67833","journal":"Neurology","n_participants":717,"pmid":"20007524","source_url":"https://pubmed.ncbi.nlm.nih.gov/20007524/","study_design":null,"title":"Association of parental dementia with cognitive and brain MRI measures in middle-aged adults","title_match":false,"year":2009},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/presymptomatic-atrophy-in-autosomal-dominant-alzheimer-s-disease-a-28738187","doi":"10.1016/j.jalz.2017.06.2268","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":94,"pmid":"28738187","source_url":"https://pubmed.ncbi.nlm.nih.gov/28738187/","study_design":null,"title":"Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A\u00a0serial magnetic resonance imaging study","title_match":true,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/environmental-enrichment-mitigates-cognitive-deficits-in-a-mouse-15917461","doi":"10.1523/jneurosci.5080-04.2005","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"15917461","source_url":"https://pubmed.ncbi.nlm.nih.gov/15917461/","study_design":null,"title":"Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease","title_match":false,"year":2005},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/glutaminyl-cyclase-inhibition-attenuates-pyroglutamate-abeta-and-18836460","doi":"10.1038/nm.1872","journal":"Nature medicine","n_participants":null,"pmid":"18836460","source_url":"https://pubmed.ncbi.nlm.nih.gov/18836460/","study_design":null,"title":"Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-especially-apolipoprotein-e4-increases-the-23100439","doi":"10.1523/jneurosci.1542-12.2012","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"23100439","source_url":"https://pubmed.ncbi.nlm.nih.gov/23100439/","study_design":null,"title":"Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid \u03b2 peptide","title_match":false,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/genes-associated-with-alzheimer-s-disease-an-overview-and-current-27274215","doi":"10.2147/cia.s105769","journal":"Clinical interventions in aging","n_participants":null,"pmid":"27274215","source_url":"https://pubmed.ncbi.nlm.nih.gov/27274215/","study_design":null,"title":"Genes associated with Alzheimer's disease: an overview and current status","title_match":false,"year":2016},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/c9orf72-suppresses-systemic-and-neural-inflammation-induced-by-gut-32483373","doi":"10.1038/s41586-020-2288-7","journal":"Nature","n_participants":null,"pmid":"32483373","source_url":"https://pubmed.ncbi.nlm.nih.gov/32483373/","study_design":null,"title":"C9orf72 suppresses systemic and neural inflammation induced by gut bacteria","title_match":false,"year":2020},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/exome-sequencing-identifies-rare-damaging-variants-in-atp8b4-and-36411364","doi":"10.1038/s41588-022-01208-7","journal":"Nature genetics","n_participants":32558,"pmid":"36411364","source_url":"https://pubmed.ncbi.nlm.nih.gov/36411364/","study_design":null,"title":"Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/neuropathologic-substrates-of-ischemic-vascular-dementia-11089571","doi":"10.1093/jnen/59.11.931","journal":"Journal of neuropathology and experimental neurology","n_participants":20,"pmid":"11089571","source_url":"https://pubmed.ncbi.nlm.nih.gov/11089571/","study_design":"longitudinal study","title":"Neuropathologic substrates of ischemic vascular dementia","title_match":false,"year":2000},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/genome-wide-association-studies-of-cerebral-white-matter-lesion-21681796","doi":"10.1002/ana.22403","journal":"Annals of neurology","n_participants":3024,"pmid":"21681796","source_url":"https://pubmed.ncbi.nlm.nih.gov/21681796/","study_design":"meta-analysis","title":"Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium","title_match":false,"year":2011},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/frequency-of-the-c9orf72-hexanucleotide-repeat-expansion-in-patients-22406228","doi":"10.1016/s1474-4422(12)70043-1","journal":"The Lancet. Neurology","n_participants":4448,"pmid":"22406228","source_url":"https://pubmed.ncbi.nlm.nih.gov/22406228/","study_design":null,"title":"Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study","title_match":false,"year":2012},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-epidemiology-of-frontotemporal-dementia-23611343","doi":"10.3109/09540261.2013.776523","journal":"International review of psychiatry (Abingdon, England)","n_participants":null,"pmid":"23611343","source_url":"https://pubmed.ncbi.nlm.nih.gov/23611343/","study_design":null,"title":"The epidemiology of frontotemporal dementia","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/advances-in-understanding-the-molecular-basis-of-frontotemporal-22732773","doi":"10.1038/nrneurol.2012.117","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"22732773","source_url":"https://pubmed.ncbi.nlm.nih.gov/22732773/","study_design":null,"title":"Advances in understanding the molecular basis of frontotemporal dementia","title_match":false,"year":2012},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/epidemiology-of-and-risk-factors-for-psychosis-of-alzheimer-s-disease-16263838","doi":"10.1176/appi.ajp.162.11.2022","journal":"The American journal of psychiatry","n_participants":9749,"pmid":"16263838","source_url":"https://pubmed.ncbi.nlm.nih.gov/16263838/","study_design":"longitudinal study","title":"Epidemiology of and risk factors for psychosis of Alzheimer's disease: a review of 55 studies published from 1990 to 2003","title_match":false,"year":2005},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-apolipoprotein-epsilon-4-allele-in-patients-with-alzheimer-s-8239575","doi":"10.1002/ana.410340527","journal":"Annals of neurology","n_participants":null,"pmid":"8239575","source_url":"https://pubmed.ncbi.nlm.nih.gov/8239575/","study_design":null,"title":"The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease","title_match":false,"year":1993},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/the-landscape-of-genetic-diseases-in-saudi-arabia-based-on-the-first-28600779","doi":"10.1007/s00439-017-1821-8","journal":"Human genetics","n_participants":1019,"pmid":"28600779","source_url":"https://pubmed.ncbi.nlm.nih.gov/28600779/","study_design":null,"title":"The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/ubiquitin-immunoreactive-intraneuronal-inclusions-in-amyotrophic-1646064","doi":"10.1093/brain/114.2.775","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"1646064","source_url":"https://pubmed.ncbi.nlm.nih.gov/1646064/","study_design":null,"title":"Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity","title_match":false,"year":1991},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/clinical-characteristics-in-early-parkinson-s-disease-in-a-central-15954133","doi":"10.1002/mds.20513","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":162,"pmid":"15954133","source_url":"https://pubmed.ncbi.nlm.nih.gov/15954133/","study_design":null,"title":"Clinical characteristics in early Parkinson's disease in a central California population-based study","title_match":false,"year":2005},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/association-of-alzheimer-disease-with-life-expectancy-in-people-with-35604690","doi":"10.1001/jamanetworkopen.2022.12910","journal":"JAMA network open","n_participants":77,"pmid":"35604690","source_url":"https://pubmed.ncbi.nlm.nih.gov/35604690/","study_design":"meta-analysis","title":"Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome","title_match":false,"year":2022},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/the-neuronal-ceroid-lipofuscinoses-from-past-to-present-16908122","doi":"10.1016/j.bbadis.2006.06.010","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"16908122","source_url":"https://pubmed.ncbi.nlm.nih.gov/16908122/","study_design":null,"title":"The neuronal ceroid-lipofuscinoses: from past to present","title_match":false,"year":2006},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-genetic-landscape-of-parkinson-s-disease-30245141","doi":"10.1016/j.neurol.2018.08.004","journal":"Revue neurologique","n_participants":null,"pmid":"30245141","source_url":"https://pubmed.ncbi.nlm.nih.gov/30245141/","study_design":null,"title":"The genetic landscape of Parkinson's disease","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/prevalence-of-dementia-in-three-ethnic-groups-the-south-florida-12875807","doi":"10.1016/s1047-2797(02)00437-4","journal":"Annals of epidemiology","n_participants":null,"pmid":"12875807","source_url":"https://pubmed.ncbi.nlm.nih.gov/12875807/","study_design":null,"title":"Prevalence of dementia in three ethnic groups: the South Florida program on aging and health","title_match":false,"year":2003},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/why-do-ethnic-elders-present-later-to-uk-dementia-services-a-21349212","doi":"10.1017/s1041610211000214","journal":"International psychogeriatrics","n_participants":null,"pmid":"21349212","source_url":"https://pubmed.ncbi.nlm.nih.gov/21349212/","study_design":null,"title":"Why do ethnic elders present later to UK dementia services? A qualitative study","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/risk-factors-for-alzheimer-s-disease-and-dementia-a-case-control-8290099","doi":"10.1212/wnl.44.1.97","journal":"Neurology","n_participants":1545,"pmid":"8290099","source_url":"https://pubmed.ncbi.nlm.nih.gov/8290099/","study_design":null,"title":"Risk factors for Alzheimer's disease and dementia: a case-control study based on the MRC elderly hypertension trial","title_match":false,"year":1994},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/familial-non-specific-dementia-maps-to-chromosome-3-8541850","doi":"10.1093/hmg/4.9.1625","journal":"Human molecular genetics","n_participants":null,"pmid":"8541850","source_url":"https://pubmed.ncbi.nlm.nih.gov/8541850/","study_design":null,"title":"Familial non-specific dementia maps to chromosome 3","title_match":true,"year":1995},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/frequency-of-alzheimer-s-disease-and-other-dementias-in-a-community-11890488","doi":"10.1046/j.1532-5415.2001.49257.x","journal":"Journal of the American Geriatrics Society","n_participants":null,"pmid":"11890488","source_url":"https://pubmed.ncbi.nlm.nih.gov/11890488/","study_design":null,"title":"Frequency of Alzheimer's disease and other dementias in a community outreach sample of Hispanics","title_match":false,"year":2001},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/an-epidemiological-study-of-dementia-in-a-rural-community-in-kerala-8773818","doi":"10.1192/bjp.168.6.745","journal":"The British journal of psychiatry : the journal of mental science","n_participants":2067,"pmid":"8773818","source_url":"https://pubmed.ncbi.nlm.nih.gov/8773818/","study_design":null,"title":"An epidemiological study of dementia in a rural community in Kerala, India","title_match":false,"year":1996},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/use-of-an-alzheimer-s-disease-polygenic-risk-score-to-identify-mild-29487403","doi":"10.1038/s41380-018-0030-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"29487403","source_url":"https://pubmed.ncbi.nlm.nih.gov/29487403/","study_design":null,"title":"Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s","title_match":true,"year":2019},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/heritability-of-leukoaraiosis-in-hypertensive-sibships-14718359","doi":"10.1161/01.hyp.0000112303.26158.92","journal":"Hypertension (Dallas, Tex. : 1979)","n_participants":null,"pmid":"14718359","source_url":"https://pubmed.ncbi.nlm.nih.gov/14718359/","study_design":null,"title":"Heritability of leukoaraiosis in hypertensive sibships","title_match":true,"year":2004},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-neuropathological-comorbidities-are-common-in-the-33285640","doi":"10.3233/jad-201213","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"33285640","source_url":"https://pubmed.ncbi.nlm.nih.gov/33285640/","study_design":null,"title":"Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old","title_match":false,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/characteristics-of-nonresponders-in-a-community-survey-of-the-elderly-7983287","doi":"10.1111/j.1532-5415.1994.tb06506.x","journal":"Journal of the American Geriatrics Society","n_participants":null,"pmid":"7983287","source_url":"https://pubmed.ncbi.nlm.nih.gov/7983287/","study_design":"cross-sectional","title":"Characteristics of nonresponders in a community survey of the elderly","title_match":false,"year":1994},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genome-wide-analysis-of-genetic-predisposition-to-alzheimer-s-disease-30636644","doi":"10.1186/s13195-018-0458-8","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"30636644","source_url":"https://pubmed.ncbi.nlm.nih.gov/30636644/","study_design":null,"title":"Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities","title_match":false,"year":2019},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/ordered-assembly-of-tau-protein-and-neurodegeneration-32096024","doi":"10.1007/978-981-32-9358-8_1","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"32096024","source_url":"https://pubmed.ncbi.nlm.nih.gov/32096024/","study_design":null,"title":"Ordered Assembly of Tau Protein and Neurodegeneration","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/incidence-and-predictors-of-advance-care-planning-among-persons-with-21785291","doi":"10.1097/jgp.0b013e3181faebef","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":127,"pmid":"21785291","source_url":"https://pubmed.ncbi.nlm.nih.gov/21785291/","study_design":null,"title":"Incidence and predictors of advance care planning among persons with cognitive impairment","title_match":false,"year":2011},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-relationship-between-alcohol-consumption-cognitive-performance-8855993","doi":"10.1111/j.1532-5415.1996.tb01364.x","journal":"Journal of the American Geriatrics Society","n_participants":null,"pmid":"8855993","source_url":"https://pubmed.ncbi.nlm.nih.gov/8855993/","study_design":null,"title":"The relationship between alcohol consumption, cognitive performance, and daily functioning in an urban sample of older black Americans","title_match":false,"year":1996},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/stroke-cerebrovascular-diseases-and-vascular-cognitive-impairment-in-29807146","doi":"10.1016/j.brainresbull.2018.05.018","journal":"Brain research bulletin","n_participants":null,"pmid":"29807146","source_url":"https://pubmed.ncbi.nlm.nih.gov/29807146/","study_design":null,"title":"Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa","title_match":false,"year":2019},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/epidemiology-of-dementia-in-nigeria-results-from-the-indianapolis-11054131","doi":"10.1046/j.1468-1331.2000.00124.x","journal":"European journal of neurology","n_participants":null,"pmid":"11054131","source_url":"https://pubmed.ncbi.nlm.nih.gov/11054131/","study_design":null,"title":"Epidemiology of dementia in Nigeria: results from the Indianapolis-Ibadan study","title_match":false,"year":2000},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-s-disease-in-caribbean-hispanic-and-african-23890735","doi":"10.1016/j.biopsych.2013.06.003","journal":"Biological psychiatry","n_participants":null,"pmid":"23890735","source_url":"https://pubmed.ncbi.nlm.nih.gov/23890735/","study_design":null,"title":"Genetics of Alzheimer's disease in Caribbean Hispanic and African American populations","title_match":false,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/fronto-temporal-dementia-nosology-neuropsychology-and-neuropathology-8811995","doi":"10.1006/brcg.1996.0041","journal":"Brain and cognition","n_participants":null,"pmid":"8811995","source_url":"https://pubmed.ncbi.nlm.nih.gov/8811995/","study_design":null,"title":"Fronto-temporal dementia: nosology, neuropsychology, and neuropathology","title_match":false,"year":1996},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/defining-the-spectrum-of-frontotemporal-dementias-associated-with-27280171","doi":"10.1212/nxg.0000000000000080","journal":"Neurology. Genetics","n_participants":null,"pmid":"27280171","source_url":"https://pubmed.ncbi.nlm.nih.gov/27280171/","study_design":null,"title":"Defining the spectrum of frontotemporal dementias associated with TARDBP mutations","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/risk-factors-for-phenoconversion-in-rapid-eye-movement-sleep-behavior-34981563","doi":"10.1002/ana.26298","journal":"Annals of neurology","n_participants":319,"pmid":"34981563","source_url":"https://pubmed.ncbi.nlm.nih.gov/34981563/","study_design":null,"title":"Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder","title_match":false,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/validation-of-a-polygenic-risk-score-for-dementia-in-black-and-white-25328845","doi":"10.1002/brb3.248","journal":"Brain and behavior","n_participants":10401,"pmid":"25328845","source_url":"https://pubmed.ncbi.nlm.nih.gov/25328845/","study_design":"meta-analysis","title":"Validation of a polygenic risk score for dementia in black and white individuals","title_match":true,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/determinants-for-undetected-dementia-and-late-life-depression-23888000","doi":"10.1192/bjp.bp.112.119354","journal":"The British journal of psychiatry : the journal of mental science","n_participants":359,"pmid":"23888000","source_url":"https://pubmed.ncbi.nlm.nih.gov/23888000/","study_design":null,"title":"Determinants for undetected dementia and late-life depression","title_match":false,"year":2013},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/role-of-genes-and-environments-for-explaining-alzheimer-disease-16461860","doi":"10.1001/archpsyc.63.2.168","journal":"Archives of general psychiatry","n_participants":11884,"pmid":"16461860","source_url":"https://pubmed.ncbi.nlm.nih.gov/16461860/","study_design":null,"title":"Role of genes and environments for explaining Alzheimer disease","title_match":false,"year":2006},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/exome-sequencing-reveals-vcp-mutations-as-a-cause-of-familial-als-21145000","doi":"10.1016/j.neuron.2010.11.036","journal":"Neuron","n_participants":null,"pmid":"21145000","source_url":"https://pubmed.ncbi.nlm.nih.gov/21145000/","study_design":null,"title":"Exome sequencing reveals VCP mutations as a cause of familial ALS","title_match":true,"year":2010},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/simvastatin-strongly-reduces-levels-of-alzheimer-s-disease-beta-11296263","doi":"10.1073/pnas.081620098","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"11296263","source_url":"https://pubmed.ncbi.nlm.nih.gov/11296263/","study_design":null,"title":"Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo","title_match":false,"year":2001},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/down-syndrome-32029743","doi":"10.1038/s41572-019-0143-7","journal":"Nature reviews. Disease primers","n_participants":null,"pmid":"32029743","source_url":"https://pubmed.ncbi.nlm.nih.gov/32029743/","study_design":null,"title":"Down syndrome","title_match":false,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/apoe-in-alzheimer-s-disease-pathophysiology-and-therapeutic-strategies-36348357","doi":"10.1186/s13024-022-00574-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"36348357","source_url":"https://pubmed.ncbi.nlm.nih.gov/36348357/","study_design":null,"title":"ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies","title_match":false,"year":2022},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/epilepsy-and-cognitive-impairments-in-alzheimer-disease-19204149","doi":"10.1001/archneurol.2009.15","journal":"Archives of neurology","n_participants":null,"pmid":"19204149","source_url":"https://pubmed.ncbi.nlm.nih.gov/19204149/","study_design":null,"title":"Epilepsy and cognitive impairments in Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/linkage-of-a-prion-protein-missense-variant-to-gerstmann-straussler-2564168","doi":"10.1038/338342a0","journal":"Nature","n_participants":null,"pmid":"2564168","source_url":"https://pubmed.ncbi.nlm.nih.gov/2564168/","study_design":null,"title":"Linkage of a prion protein missense variant to Gerstmann-Str\u00e4ussler syndrome","title_match":false,"year":1989},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-a-review-24389262","doi":"10.2741/s415","journal":"Frontiers in bioscience (Scholar edition)","n_participants":null,"pmid":"24389262","source_url":"https://pubmed.ncbi.nlm.nih.gov/24389262/","study_design":null,"title":"Parkinson's disease: a review","title_match":false,"year":2014},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/rates-and-risk-factors-for-dementia-and-alzheimer-s-disease-results-9921852","doi":"10.1212/wnl.52.1.78","journal":"Neurology","n_participants":null,"pmid":"9921852","source_url":"https://pubmed.ncbi.nlm.nih.gov/9921852/","study_design":"cross-sectional","title":"Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia","title_match":false,"year":1999},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/cognitive-and-clinical-characteristics-of-patients-with-amyotrophic-22305801","doi":"10.1016/s1474-4422(12)70014-5","journal":"The Lancet. Neurology","n_participants":49,"pmid":"22305801","source_url":"https://pubmed.ncbi.nlm.nih.gov/22305801/","study_design":"longitudinal study","title":"Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/loss-of-function-mutations-in-tyrobp-dap12-result-in-a-presenile-10888890","doi":"10.1038/77153","journal":"Nature genetics","n_participants":null,"pmid":"10888890","source_url":"https://pubmed.ncbi.nlm.nih.gov/10888890/","study_design":null,"title":"Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts","title_match":false,"year":2000},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/hypoxia-inducible-factor-1alpha-hif-1alpha-mediated-hypoxia-increases-17303576","doi":"10.1074/jbc.m608856200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"17303576","source_url":"https://pubmed.ncbi.nlm.nih.gov/17303576/","study_design":null,"title":"Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation","title_match":false,"year":2007},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/apoe4-homozygozity-represents-a-distinct-genetic-form-of-alzheimer-s-38710950","doi":"10.1038/s41591-024-02931-w","journal":"Nature medicine","n_participants":3297,"pmid":"38710950","source_url":"https://pubmed.ncbi.nlm.nih.gov/38710950/","study_design":null,"title":"APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-identifies-19p13-3-unc13a-and-9p21-2-as-19734901","doi":"10.1038/ng.442","journal":"Nature genetics","n_participants":2323,"pmid":"19734901","source_url":"https://pubmed.ncbi.nlm.nih.gov/19734901/","study_design":null,"title":"Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis","title_match":false,"year":2009},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/frontotemporal-dementia-and-its-subtypes-a-genome-wide-association-24943344","doi":"10.1016/s1474-4422(14)70065-1","journal":"The Lancet. Neurology","n_participants":3526,"pmid":"24943344","source_url":"https://pubmed.ncbi.nlm.nih.gov/24943344/","study_design":"meta-analysis","title":"Frontotemporal dementia and its subtypes: a genome-wide association study","title_match":false,"year":2014},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/tau-is-a-candidate-gene-for-chromosome-17-frontotemporal-dementia-9629852","doi":"10.1002/ana.410430617","journal":"Annals of neurology","n_participants":null,"pmid":"9629852","source_url":"https://pubmed.ncbi.nlm.nih.gov/9629852/","study_design":null,"title":"Tau is a candidate gene for chromosome 17 frontotemporal dementia","title_match":false,"year":1998},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/clinical-characteristics-of-a-family-with-chromosome-17-linked-7936241","doi":"10.1212/wnl.44.10.1878","journal":"Neurology","n_participants":null,"pmid":"7936241","source_url":"https://pubmed.ncbi.nlm.nih.gov/7936241/","study_design":null,"title":"Clinical characteristics of a family with chromosome 17-linked disinhibition-dementia-parkinsonism-amyotrophy complex","title_match":false,"year":1994},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/aphasia-in-dementia-of-the-alzheimer-type-3974897","doi":"10.1212/wnl.35.3.394","journal":"Neurology","n_participants":30,"pmid":"3974897","source_url":"https://pubmed.ncbi.nlm.nih.gov/3974897/","study_design":null,"title":"Aphasia in dementia of the Alzheimer type","title_match":false,"year":1985},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/age-and-disease-dependent-increase-of-the-mitophagy-marker-phospho-29947276","doi":"10.1080/15548627.2018.1461294","journal":"Autophagy","n_participants":null,"pmid":"29947276","source_url":"https://pubmed.ncbi.nlm.nih.gov/29947276/","study_design":null,"title":"Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease","title_match":false,"year":2018},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/a-cerebrospinal-fluid-synaptic-protein-biomarker-for-prediction-of-40164724","doi":"10.1038/s41591-025-03565-2","journal":"Nature medicine","n_participants":3397,"pmid":"40164724","source_url":"https://pubmed.ncbi.nlm.nih.gov/40164724/","study_design":"case-control study","title":"A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/familial-frontotemporal-dementia-with-ubiquitin-positive-inclusions-11571213","doi":"10.1093/brain/124.10.1948","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"11571213","source_url":"https://pubmed.ncbi.nlm.nih.gov/11571213/","study_design":null,"title":"Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22","title_match":true,"year":2001},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/frontotemporal-lobar-degeneration-epidemiology-pathology-diagnosis-22950490","doi":"10.2165/11640070-000000000-00000","journal":"CNS drugs","n_participants":null,"pmid":"22950490","source_url":"https://pubmed.ncbi.nlm.nih.gov/22950490/","study_design":null,"title":"Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management","title_match":false,"year":2012},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/hereditary-frontotemporal-dementia-is-linked-to-chromosome-17q21-q22-9029063","doi":"10.1002/ana.410410205","journal":"Annals of neurology","n_participants":null,"pmid":"9029063","source_url":"https://pubmed.ncbi.nlm.nih.gov/9029063/","study_design":null,"title":"Hereditary frontotemporal dementia is linked to chromosome 17q21-q22: a genetic and clinicopathological study of three Dutch families","title_match":false,"year":1997},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/impaired-cognition-and-brain-atrophy-decades-after-hypertensive-26908863","doi":"10.1161/circoutcomes.115.002461","journal":"Circulation. Cardiovascular quality and outcomes","n_participants":1279,"pmid":"26908863","source_url":"https://pubmed.ncbi.nlm.nih.gov/26908863/","study_design":null,"title":"Impaired Cognition and Brain Atrophy Decades After Hypertensive Pregnancy Disorders","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/the-tauopathy-associated-with-mutation-3-in-intron-10-of-tau-18065436","doi":"10.1093/brain/awm280","journal":"Brain : a journal of neurology","n_participants":21,"pmid":"18065436","source_url":"https://pubmed.ncbi.nlm.nih.gov/18065436/","study_design":"longitudinal study","title":"The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family","title_match":false,"year":2008},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/modifiable-risk-factors-for-dementia-and-dementia-risk-profiling-a-34635138","doi":"10.1186/s13195-021-00895-4","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"34635138","source_url":"https://pubmed.ncbi.nlm.nih.gov/34635138/","study_design":null,"title":"Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6","title_match":false,"year":2021},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-4-carriers-share-immune-related-proteomic-changes-across-40665049","doi":"10.1038/s41591-025-03835-z","journal":"Nature medicine","n_participants":null,"pmid":"40665049","source_url":"https://pubmed.ncbi.nlm.nih.gov/40665049/","study_design":null,"title":"APOE \u03b54 carriers share immune-related proteomic changes across neurodegenerative diseases","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/als-and-other-motor-neuron-diseases-25299277","doi":"10.1212/01.con.0000455886.14298.a4","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"25299277","source_url":"https://pubmed.ncbi.nlm.nih.gov/25299277/","study_design":null,"title":"ALS and other motor neuron diseases","title_match":false,"year":2014},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/familial-idiopathic-cerebral-calcifications-886353","doi":"10.1136/jnnp.40.3.280","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"886353","source_url":"https://pubmed.ncbi.nlm.nih.gov/886353/","study_design":null,"title":"Familial idiopathic cerebral calcifications","title_match":true,"year":1977},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/frontotemporal-dementia-patient-characteristics-cognition-and-12325050","doi":"10.1002/gps.709","journal":"International journal of geriatric psychiatry","n_participants":30,"pmid":"12325050","source_url":"https://pubmed.ncbi.nlm.nih.gov/12325050/","study_design":null,"title":"Frontotemporal dementia: patient characteristics, cognition, and behaviour","title_match":false,"year":2002},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/clinicopathological-features-of-familial-alzheimer-s-disease-9126060","doi":"10.1093/brain/120.3.491","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"9126060","source_url":"https://pubmed.ncbi.nlm.nih.gov/9126060/","study_design":null,"title":"Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor","title_match":true,"year":1997},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/recurrent-mutations-in-dnajc5-cause-autosomal-dominant-kufs-disease-22978711","doi":"10.1111/cge.12020","journal":"Clinical genetics","n_participants":20,"pmid":"22978711","source_url":"https://pubmed.ncbi.nlm.nih.gov/22978711/","study_design":null,"title":"Recurrent mutations in DNAJC5 cause autosomal dominant Kufs disease","title_match":true,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neuropsychological-performance-in-advanced-age-influences-of-18609337","doi":"10.1080/13854040801894730","journal":"The Clinical neuropsychologist","n_participants":507,"pmid":"18609337","source_url":"https://pubmed.ncbi.nlm.nih.gov/18609337/","study_design":null,"title":"Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study","title_match":false,"year":2009},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/predicting-cognitive-impairment-and-dementia-a-machine-learning-32333585","doi":"10.3233/jad-190967","journal":"Journal of Alzheimer's disease : JAD","n_participants":9979,"pmid":"32333585","source_url":"https://pubmed.ncbi.nlm.nih.gov/32333585/","study_design":"post-hoc analysis","title":"Predicting Cognitive Impairment and Dementia: A Machine Learning Approach","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/parkinsonism-and-frontotemporal-dementia-the-clinical-overlap-21892619","doi":"10.1007/s12031-011-9632-1","journal":"Journal of molecular neuroscience : MN","n_participants":null,"pmid":"21892619","source_url":"https://pubmed.ncbi.nlm.nih.gov/21892619/","study_design":null,"title":"Parkinsonism and frontotemporal dementia: the clinical overlap","title_match":false,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/benchmarking-machine-learning-models-for-late-onset-alzheimer-s-31842725","doi":"10.1186/s12859-019-3158-x","journal":"BMC bioinformatics","n_participants":null,"pmid":"31842725","source_url":"https://pubmed.ncbi.nlm.nih.gov/31842725/","study_design":null,"title":"Benchmarking machine learning models for late-onset alzheimer's disease prediction from genomic data","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/dementia-lacking-distinctive-histopathology-clinicopathological-7610766","doi":"10.1007/bf00309628","journal":"Acta neuropathologica","n_participants":32,"pmid":"7610766","source_url":"https://pubmed.ncbi.nlm.nih.gov/7610766/","study_design":null,"title":"Dementia lacking distinctive histopathology: clinicopathological evaluation of 32 cases","title_match":false,"year":1995},{"alzhub_score":85,"alzhub_url":"https://alzhub.org/study/genetic-meta-analysis-of-diagnosed-alzheimer-s-disease-identifies-new-30820047","doi":"10.1038/s41588-019-0358-2","journal":"Nature genetics","n_participants":94437,"pmid":"30820047","source_url":"https://pubmed.ncbi.nlm.nih.gov/30820047/","study_design":"meta-analysis","title":"Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing","title_match":false,"year":2019},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-controls-cerebrovascular-integrity-via-cyclophilin-a-22622580","doi":"10.1038/nature11087","journal":"Nature","n_participants":null,"pmid":"22622580","source_url":"https://pubmed.ncbi.nlm.nih.gov/22622580/","study_design":null,"title":"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A","title_match":false,"year":2012},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/patterns-of-brain-activation-in-people-at-risk-for-alzheimer-s-disease-10944562","doi":"10.1056/nejm200008173430701","journal":"The New England journal of medicine","n_participants":30,"pmid":"10944562","source_url":"https://pubmed.ncbi.nlm.nih.gov/10944562/","study_design":null,"title":"Patterns of brain activation in people at risk for Alzheimer's disease","title_match":false,"year":2000},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/preclinical-evidence-of-alzheimer-s-disease-in-persons-homozygous-for-8592548","doi":"10.1056/nejm199603213341202","journal":"The New England journal of medicine","n_participants":null,"pmid":"8592548","source_url":"https://pubmed.ncbi.nlm.nih.gov/8592548/","study_design":null,"title":"Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E","title_match":false,"year":1996},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/risk-factors-for-alzheimer-s-disease-a-prospective-analysis-from-the-12196314","doi":"10.1093/aje/kwf074","journal":"American journal of epidemiology","n_participants":194,"pmid":"12196314","source_url":"https://pubmed.ncbi.nlm.nih.gov/12196314/","study_design":null,"title":"Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging","title_match":false,"year":2002},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-a-matter-of-blood-brain-barrier-dysfunction-29061693","doi":"10.1084/jem.20171406","journal":"The Journal of experimental medicine","n_participants":null,"pmid":"29061693","source_url":"https://pubmed.ncbi.nlm.nih.gov/29061693/","study_design":null,"title":"Alzheimer's disease: A matter of blood-brain barrier dysfunction?","title_match":false,"year":2017},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/common-variants-at-7p21-are-associated-with-frontotemporal-lobar-20154673","doi":"10.1038/ng.536","journal":"Nature genetics","n_participants":515,"pmid":"20154673","source_url":"https://pubmed.ncbi.nlm.nih.gov/20154673/","study_design":null,"title":"Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions","title_match":false,"year":2010},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-is-part-of-a-diverse-and-highly-conserved-interaction-19182805","doi":"10.1038/ng.300","journal":"Nature genetics","n_participants":null,"pmid":"19182805","source_url":"https://pubmed.ncbi.nlm.nih.gov/19182805/","study_design":null,"title":"Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity","title_match":false,"year":2009},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/melas-syndrome-clinical-manifestations-pathogenesis-and-treatment-26095523","doi":"10.1016/j.ymgme.2015.06.004","journal":"Molecular genetics and metabolism","n_participants":null,"pmid":"26095523","source_url":"https://pubmed.ncbi.nlm.nih.gov/26095523/","study_design":null,"title":"MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options","title_match":false,"year":2015},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/tbk1-suppresses-ripk1-driven-apoptosis-and-inflammation-during-30146158","doi":"10.1016/j.cell.2018.07.041","journal":"Cell","n_participants":null,"pmid":"30146158","source_url":"https://pubmed.ncbi.nlm.nih.gov/30146158/","study_design":null,"title":"TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging","title_match":false,"year":2018},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-insulin-levels-in-alzheimer-s-disease-9443474","doi":"10.1212/wnl.50.1.164","journal":"Neurology","n_participants":25,"pmid":"9443474","source_url":"https://pubmed.ncbi.nlm.nih.gov/9443474/","study_design":null,"title":"Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype","title_match":false,"year":1998},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/head-trauma-as-a-risk-factor-for-alzheimer-s-disease-a-collaborative-1833351","doi":"10.1093/ije/20.supplement_2.s28","journal":"International journal of epidemiology","n_participants":null,"pmid":"1833351","source_url":"https://pubmed.ncbi.nlm.nih.gov/1833351/","study_design":"case-control study","title":"Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group","title_match":false,"year":1991},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/trem2-in-neurodegeneration-evidence-for-association-of-the-p-r47h-23800361","doi":"10.1186/1750-1326-8-19","journal":"Molecular neurodegeneration","n_participants":609,"pmid":"23800361","source_url":"https://pubmed.ncbi.nlm.nih.gov/23800361/","study_design":null,"title":"TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-8485581","doi":"10.1038/ng0393-256","journal":"Nature genetics","n_participants":null,"pmid":"8485581","source_url":"https://pubmed.ncbi.nlm.nih.gov/8485581/","study_design":null,"title":"Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12","title_match":true,"year":1993},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-synapse-loss-and-neurodegeneration-in-alzheimer-s-33139712","doi":"10.1038/s41467-020-19264-0","journal":"Nature communications","n_participants":null,"pmid":"33139712","source_url":"https://pubmed.ncbi.nlm.nih.gov/33139712/","study_design":null,"title":"APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/mutations-causing-neurodegenerative-tauopathies-15615642","doi":"10.1016/j.bbadis.2004.08.007","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"15615642","source_url":"https://pubmed.ncbi.nlm.nih.gov/15615642/","study_design":null,"title":"Mutations causing neurodegenerative tauopathies","title_match":false,"year":2005},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/reduced-hippocampal-volumes-and-memory-loss-in-patients-with-early-15738499","doi":"10.1192/bjp.186.3.197","journal":"The British journal of psychiatry : the journal of mental science","n_participants":66,"pmid":"15738499","source_url":"https://pubmed.ncbi.nlm.nih.gov/15738499/","study_design":null,"title":"Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression","title_match":false,"year":2005},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/synuclein-in-the-pathophysiology-of-alzheimer-s-disease-31186026","doi":"10.1186/s13024-019-0320-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31186026","source_url":"https://pubmed.ncbi.nlm.nih.gov/31186026/","study_design":null,"title":"\u03b1-synuclein in the pathophysiology of Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-dementias-12480441","doi":"10.1016/s0140-6736(02)11667-9","journal":"Lancet (London, England)","n_participants":null,"pmid":"12480441","source_url":"https://pubmed.ncbi.nlm.nih.gov/12480441/","study_design":null,"title":"The dementias","title_match":false,"year":2002},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-cascade-hypothesis-in-the-pathogenesis-of-alzheimer-s-disease-35298921","doi":"10.1016/j.neuron.2022.03.004","journal":"Neuron","n_participants":null,"pmid":"35298921","source_url":"https://pubmed.ncbi.nlm.nih.gov/35298921/","study_design":null,"title":"ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/development-of-dementing-illnesses-in-an-80-year-old-volunteer-cohort-2712531","doi":"10.1002/ana.410250402","journal":"Annals of neurology","n_participants":null,"pmid":"2712531","source_url":"https://pubmed.ncbi.nlm.nih.gov/2712531/","study_design":null,"title":"Development of dementing illnesses in an 80-year-old volunteer cohort","title_match":false,"year":1989},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/evidence-of-oxidative-stress-in-alzheimer-s-disease-brain-and-19076432","doi":"10.1196/annals.1427.010","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"19076432","source_url":"https://pubmed.ncbi.nlm.nih.gov/19076432/","study_design":null,"title":"Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows","title_match":false,"year":2008},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-association-with-dementia-in-a-population-8618665","doi":"10.1212/wnl.46.3.673","journal":"Neurology","n_participants":21,"pmid":"8618665","source_url":"https://pubmed.ncbi.nlm.nih.gov/8618665/","study_design":null,"title":"Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study","title_match":false,"year":1996},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/loneliness-and-risk-of-dementia-30365023","doi":"10.1093/geronb/gby112","journal":"The journals of gerontology. Series B, Psychological sciences and social sciences","n_participants":12030,"pmid":"30365023","source_url":"https://pubmed.ncbi.nlm.nih.gov/30365023/","study_design":null,"title":"Loneliness and Risk of Dementia","title_match":false,"year":2020},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/mri-hyperintensities-of-the-temporal-lobe-and-external-capsule-in-11245715","doi":"10.1212/wnl.56.5.628","journal":"Neurology","n_participants":20,"pmid":"11245715","source_url":"https://pubmed.ncbi.nlm.nih.gov/11245715/","study_design":null,"title":"MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL","title_match":false,"year":2001},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/amyloid-beta-protein-gene-cdna-mrna-distribution-and-genetic-linkage-2949367","doi":"10.1126/science.2949367","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"2949367","source_url":"https://pubmed.ncbi.nlm.nih.gov/2949367/","study_design":null,"title":"Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus","title_match":false,"year":1987},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disorders-associated-with-diabetes-mellitus-15175861","doi":"10.1007/s00109-004-0552-1","journal":"Journal of molecular medicine (Berlin, Germany)","n_participants":null,"pmid":"15175861","source_url":"https://pubmed.ncbi.nlm.nih.gov/15175861/","study_design":null,"title":"Neurodegenerative disorders associated with diabetes mellitus","title_match":false,"year":2004},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/hereditary-cerebral-hemorrhage-with-amyloidosis-in-patients-of-dutch-3475718","doi":"10.1073/pnas.84.16.5991","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"3475718","source_url":"https://pubmed.ncbi.nlm.nih.gov/3475718/","study_design":null,"title":"Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease","title_match":false,"year":1987},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/redox-proteomics-and-amyloid-peptide-insights-into-alzheimer-disease-30216447","doi":"10.1111/jnc.14589","journal":"Journal of neurochemistry","n_participants":null,"pmid":"30216447","source_url":"https://pubmed.ncbi.nlm.nih.gov/30216447/","study_design":null,"title":"Redox proteomics and amyloid \u03b2-peptide: insights into Alzheimer disease","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/studies-in-aging-of-the-brain-iv-familial-alzheimer-disease-relation-384295","doi":"10.1212/wnl.29.10.1402","journal":"Neurology","n_participants":null,"pmid":"384295","source_url":"https://pubmed.ncbi.nlm.nih.gov/384295/","study_design":null,"title":"Studies in aging of the brain: IV. Familial Alzheimer disease: Relation to transmissible dementia, aneuploidy, and microtubular defects","title_match":true,"year":1979},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/transactive-response-dna-binding-protein-43-burden-in-familial-20008652","doi":"10.1001/archneurol.2009.277","journal":"Archives of neurology","n_participants":42,"pmid":"20008652","source_url":"https://pubmed.ncbi.nlm.nih.gov/20008652/","study_design":null,"title":"Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome","title_match":true,"year":2009},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/are-hereditary-hemochromatosis-mutations-involved-in-alzheimer-disease-10861683","doi":"10.1002/1096-8628(20000703)93:1<58::aid-ajmg10>3.0.co;2-l","journal":"American journal of medical genetics","n_participants":26,"pmid":"10861683","source_url":"https://pubmed.ncbi.nlm.nih.gov/10861683/","study_design":null,"title":"Are hereditary hemochromatosis mutations involved in Alzheimer disease?","title_match":false,"year":2000},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/early-striatal-amyloid-deposition-distinguishes-down-syndrome-and-29477284","doi":"10.1016/j.jalz.2018.01.002","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"29477284","source_url":"https://pubmed.ncbi.nlm.nih.gov/29477284/","study_design":null,"title":"Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition","title_match":true,"year":2018},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/app717-app693-and-prip-gene-mutations-are-rare-in-alzheimer-disease-1679288","doi":null,"journal":"American journal of human genetics","n_participants":null,"pmid":"1679288","source_url":"https://pubmed.ncbi.nlm.nih.gov/1679288/","study_design":null,"title":"APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease","title_match":false,"year":1991},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alzheimer-abeta-peptide-induces-chromosome-mis-segregation-and-20032300","doi":"10.1091/mbc.e09-10-0850","journal":"Molecular biology of the cell","n_participants":null,"pmid":"20032300","source_url":"https://pubmed.ncbi.nlm.nih.gov/20032300/","study_design":null,"title":"Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP","title_match":false,"year":2010},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/glutamate-as-a-hippocampal-neuron-survival-factor-an-inherited-defect-7568199","doi":"10.1073/pnas.92.21.9692","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7568199","source_url":"https://pubmed.ncbi.nlm.nih.gov/7568199/","study_design":null,"title":"Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse","title_match":true,"year":1995},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/nih-conference-alzheimer-disease-clinical-and-biological-heterogeneity-2969203","doi":"10.7326/0003-4819-109-4-298","journal":"Annals of internal medicine","n_participants":null,"pmid":"2969203","source_url":"https://pubmed.ncbi.nlm.nih.gov/2969203/","study_design":null,"title":"NIH conference. Alzheimer disease: clinical and biological heterogeneity","title_match":false,"year":1988},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/familial-danish-dementia-co-existence-of-danish-and-alzheimer-amyloid-16091362","doi":"10.1074/jbc.m504038200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16091362","source_url":"https://pubmed.ncbi.nlm.nih.gov/16091362/","study_design":null,"title":"Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques","title_match":true,"year":2005},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/isoprostanes-a-novel-major-group-of-oxidative-stress-markers-26670350","doi":"10.13075/ijomeh.1896.00596","journal":"International journal of occupational medicine and environmental health","n_participants":null,"pmid":"26670350","source_url":"https://pubmed.ncbi.nlm.nih.gov/26670350/","study_design":null,"title":"Isoprostanes - A novel major group of oxidative stress markers","title_match":false,"year":2016},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/mapping-of-the-gene-encoding-the-beta-amyloid-precursor-protein-and-2973063","doi":"10.1073/pnas.85.21.8266","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"2973063","source_url":"https://pubmed.ncbi.nlm.nih.gov/2973063/","study_design":null,"title":"Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21","title_match":false,"year":1988},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cryo-em-structures-of-amyloid-and-tau-filaments-in-down-syndrome-38553642","doi":"10.1038/s41594-024-01252-3","journal":"Nature structural & molecular biology","n_participants":null,"pmid":"38553642","source_url":"https://pubmed.ncbi.nlm.nih.gov/38553642/","study_design":null,"title":"Cryo-EM structures of amyloid-\u03b2 and tau filaments in Down syndrome","title_match":false,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/fluorescent-light-induced-chromatid-breaks-distinguish-alzheimer-8643543","doi":"10.1073/pnas.93.10.5146","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8643543","source_url":"https://pubmed.ncbi.nlm.nih.gov/8643543/","study_design":null,"title":"Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture","title_match":false,"year":1996},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/comparative-mapping-of-dna-markers-from-the-familial-alzheimer-2901095","doi":"10.1073/pnas.85.16.6032","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"2901095","source_url":"https://pubmed.ncbi.nlm.nih.gov/2901095/","study_design":null,"title":"Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17","title_match":true,"year":1988},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/hypothesis-alzheimer-s-disease-is-a-phylogenetic-disease-2528670","doi":"10.1016/0306-9877(89)90185-0","journal":"Medical hypotheses","n_participants":null,"pmid":"2528670","source_url":"https://pubmed.ncbi.nlm.nih.gov/2528670/","study_design":null,"title":"Hypothesis: Alzheimer's disease is a phylogenetic disease","title_match":false,"year":1989},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-alzheimer-amyloid-precursor-protein-maps-to-human-chromosome-21-2527801","doi":"10.1016/0888-7543(89)90095-5","journal":"Genomics","n_participants":null,"pmid":"2527801","source_url":"https://pubmed.ncbi.nlm.nih.gov/2527801/","study_design":null,"title":"The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05","title_match":false,"year":1989},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/c-terminal-fragments-of-the-amyloid-precursor-protein-in-28559572","doi":"10.1038/s41598-017-02841-7","journal":"Scientific reports","n_participants":null,"pmid":"28559572","source_url":"https://pubmed.ncbi.nlm.nih.gov/28559572/","study_design":null,"title":"C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease","title_match":false,"year":2017},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/frameshift-proteins-in-autosomal-dominant-forms-of-alzheimer-disease-16432153","doi":"10.1212/01.wnl.0000193882.46003.6d","journal":"Neurology","n_participants":null,"pmid":"16432153","source_url":"https://pubmed.ncbi.nlm.nih.gov/16432153/","study_design":null,"title":"Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies","title_match":true,"year":2006},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/cerebral-amyloidosis-amyloid-angiopathy-and-their-relationship-to-12214074","doi":"10.3233/jad-2001-3110","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"12214074","source_url":"https://pubmed.ncbi.nlm.nih.gov/12214074/","study_design":null,"title":"Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia","title_match":false,"year":2001},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/brain-and-brawn-parallels-in-oxidative-strength-16432155","doi":"10.1212/01.wnl.0000192307.15103.83","journal":"Neurology","n_participants":null,"pmid":"16432155","source_url":"https://pubmed.ncbi.nlm.nih.gov/16432155/","study_design":null,"title":"Brain and brawn: parallels in oxidative strength","title_match":false,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/app-mutations-in-the-a-coding-region-are-associated-with-abundant-23143229","doi":"10.1007/s00401-012-1061-x","journal":"Acta neuropathologica","n_participants":null,"pmid":"23143229","source_url":"https://pubmed.ncbi.nlm.nih.gov/23143229/","study_design":null,"title":"APP mutations in the A\u03b2 coding region are associated with abundant cerebral deposition of A\u03b238","title_match":true,"year":2012},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/mosaicism-for-trisomy-21-in-a-patient-with-young-onset-dementia-a-18332257","doi":"10.1001/archneur.65.3.412","journal":"Archives of neurology","n_participants":null,"pmid":"18332257","source_url":"https://pubmed.ncbi.nlm.nih.gov/18332257/","study_design":"case report","title":"Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature review","title_match":false,"year":2008},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/tau-and-alpha-synuclein-inclusions-in-a-case-of-familial-15804056","doi":"10.1093/jnen/64.3.245","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"15804056","source_url":"https://pubmed.ncbi.nlm.nih.gov/15804056/","study_design":null,"title":"Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia","title_match":true,"year":2005},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/alzheimer-like-pattern-of-hypometabolism-emerges-with-elevated-29254096","doi":"10.3233/jad-170720","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29254096","source_url":"https://pubmed.ncbi.nlm.nih.gov/29254096/","study_design":null,"title":"Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-\u03b2 Burden in Down Syndrome","title_match":false,"year":2018},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/increased-low-level-chromosome-21-mosaicism-in-older-individuals-with-9028448","doi":"10.1002/(sici)1096-8628(19970120)68:2<147::aid-ajmg5>3.0.co;2-m","journal":"American journal of medical genetics","n_participants":15,"pmid":"9028448","source_url":"https://pubmed.ncbi.nlm.nih.gov/9028448/","study_design":null,"title":"Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome","title_match":false,"year":1997},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-disease-a-large-multigeneration-german-kindred-2025423","doi":"10.1097/00002093-199100510-00005","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"2025423","source_url":"https://pubmed.ncbi.nlm.nih.gov/2025423/","study_design":null,"title":"Familial Alzheimer disease: a large, multigeneration German kindred","title_match":true,"year":1991},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/immunoreactivity-of-presenilin-1-in-human-rat-and-mouse-brain-9200512","doi":"10.1016/s0006-8993(97)00243-6","journal":"Brain research","n_participants":null,"pmid":"9200512","source_url":"https://pubmed.ncbi.nlm.nih.gov/9200512/","study_design":null,"title":"Immunoreactivity of presenilin-1 in human, rat and mouse brain","title_match":true,"year":1997},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/alzheimer-type-pathology-in-a-patient-with-mitochondrial-myopathy-8870835","doi":"10.1007/s004010050524","journal":"Acta neuropathologica","n_participants":null,"pmid":"8870835","source_url":"https://pubmed.ncbi.nlm.nih.gov/8870835/","study_design":null,"title":"Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)","title_match":false,"year":1996},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-amyloid-cascade-hypothesis-a-conclusion-in-search-of-support-39532243","doi":"10.1016/j.ajpath.2024.10.014","journal":"The American journal of pathology","n_participants":null,"pmid":"39532243","source_url":"https://pubmed.ncbi.nlm.nih.gov/39532243/","study_design":null,"title":"The Amyloid Cascade Hypothesis: A Conclusion in Search of Support","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/microglial-activation-induced-by-factor-s-contained-in-sera-from-9822164","doi":"10.1002/(sici)1097-4547(19981115)54:4<539::aid-jnr11>3.0.co;2-q","journal":"Journal of neuroscience research","n_participants":null,"pmid":"9822164","source_url":"https://pubmed.ncbi.nlm.nih.gov/9822164/","study_design":null,"title":"Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes","title_match":false,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cell-type-specific-enhancement-of-amyloid-beta-deposition-in-a-novel-9737546","doi":"10.1097/00005072-199809000-00004","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"9737546","source_url":"https://pubmed.ncbi.nlm.nih.gov/9737546/","study_design":null,"title":"Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L)","title_match":true,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/molecular-genetics-of-alzheimer-s-disease-and-the-amyloid-beta-2504259","doi":"10.3109/07853898909149191","journal":"Annals of medicine","n_participants":null,"pmid":"2504259","source_url":"https://pubmed.ncbi.nlm.nih.gov/2504259/","study_design":null,"title":"Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene","title_match":false,"year":1989},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/proteomic-analysis-of-down-syndrome-cerebrospinal-fluid-compared-to-40595720","doi":"10.1038/s41467-025-61054-z","journal":"Nature communications","n_participants":229,"pmid":"40595720","source_url":"https://pubmed.ncbi.nlm.nih.gov/40595720/","study_design":null,"title":"Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer\u00b4s disease","title_match":true,"year":2025},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/the-down-alzheimer-barcelona-neuroimaging-initiative-dabni-and-its-40528282","doi":"10.1002/alz.70259","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1135,"pmid":"40528282","source_url":"https://pubmed.ncbi.nlm.nih.gov/40528282/","study_design":"cohort study","title":"The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/early-diagnosis-of-alzheimer-disease-with-positron-emission-tomography-10850738","doi":"10.1097/00002093-200000001-00016","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"10850738","source_url":"https://pubmed.ncbi.nlm.nih.gov/10850738/","study_design":null,"title":"Early diagnosis of Alzheimer disease with positron emission tomography","title_match":false,"year":2000},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/association-between-presenilin-1-polymorphism-and-maternal-meiosis-ii-10951459","doi":"10.1002/1096-8628(20000828)93:5<366::aid-ajmg5>3.0.co;2-g","journal":"American journal of medical genetics","n_participants":168,"pmid":"10951459","source_url":"https://pubmed.ncbi.nlm.nih.gov/10951459/","study_design":null,"title":"Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome","title_match":true,"year":2000},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/growth-properties-and-in-vitro-life-span-of-alzheimer-disease-and-2139155","doi":"10.1016/0047-6374(90)90031-a","journal":"Mechanisms of ageing and development","n_participants":null,"pmid":"2139155","source_url":"https://pubmed.ncbi.nlm.nih.gov/2139155/","study_design":null,"title":"Growth properties and in vitro life span of Alzheimer disease and Down syndrome fibroblasts. A blind study","title_match":false,"year":1990},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/absence-of-familial-association-between-dementia-of-alzheimer-type-2531979","doi":"10.1002/ajmg.1320330427","journal":"American journal of medical genetics","n_participants":null,"pmid":"2531979","source_url":"https://pubmed.ncbi.nlm.nih.gov/2531979/","study_design":"case-control study","title":"Absence of familial association between dementia of Alzheimer type and Down syndrome","title_match":true,"year":1989},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/soluble-amyloid-beta-in-the-brain-the-scarlet-pimpernel-16914851","doi":"10.3233/jad-2006-9s315","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"16914851","source_url":"https://pubmed.ncbi.nlm.nih.gov/16914851/","study_design":null,"title":"Soluble amyloid-beta in the brain: the scarlet pimpernel","title_match":false,"year":2006},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/presenilin-1-and-alpha-1-antichymotrypsin-polymorphisms-in-down-10581479","doi":"10.1002/(sici)1096-8628(19991215)88:6<616::aid-ajmg8>3.0.co;2-i","journal":"American journal of medical genetics","n_participants":231,"pmid":"10581479","source_url":"https://pubmed.ncbi.nlm.nih.gov/10581479/","study_design":null,"title":"Presenilin 1 and alpha-1-antichymotrypsin polymorphisms in Down syndrome: no effect on the presence of dementia","title_match":true,"year":1999},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/argentina-alzheimer-s-disease-neuroimaging-initiative-pioneering-39369277","doi":"10.1002/alz.14285","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39369277","source_url":"https://pubmed.ncbi.nlm.nih.gov/39369277/","study_design":"longitudinal study","title":"Argentina-Alzheimer's Disease Neuroimaging Initiative: pioneering Alzheimer's Research in Latin America and its Implications for Regional Advancement","title_match":false,"year":2024},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-in-the-parents-of-women-with-trisomic-spontaneous-10757522","doi":"10.1097/00001756-200003200-00028","journal":"Neuroreport","n_participants":109,"pmid":"10757522","source_url":"https://pubmed.ncbi.nlm.nih.gov/10757522/","study_design":null,"title":"Alzheimer's disease in the parents of women with trisomic spontaneous abortions","title_match":false,"year":2000},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/novel-snx13-frameshift-variant-in-an-individual-with-developmental-34879376","doi":"10.1159/000520296","journal":"Cytogenetic and genome research","n_participants":null,"pmid":"34879376","source_url":"https://pubmed.ncbi.nlm.nih.gov/34879376/","study_design":null,"title":"Novel SNX13 Frameshift Variant in an Individual with Developmental Delay","title_match":false,"year":2021},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/lack-of-detectable-radiation-hypersensitivity-in-lymphoblastoid-cells-8347332","doi":"10.1097/00002093-199307020-00004","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"8347332","source_url":"https://pubmed.ncbi.nlm.nih.gov/8347332/","study_design":null,"title":"Lack of detectable radiation hypersensitivity in lymphoblastoid cells from multiple pedigrees of familial Alzheimer disease","title_match":true,"year":1993},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cross-sectional-fdg-in-down-syndrome-and-autosomal-dominant-alzheimer-40977577","doi":"10.1002/ana.78002","journal":"Annals of neurology","n_participants":76,"pmid":"40977577","source_url":"https://pubmed.ncbi.nlm.nih.gov/40977577/","study_design":"cross-sectional","title":"Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease","title_match":true,"year":2025},{"alzhub_score":25,"alzhub_url":"https://alzhub.org/study/beta-amyloid-protein-probe-hybridized-to-chromosome-9-in-3-alzheimer-2690102","doi":null,"journal":"Progress in clinical and biological research","n_participants":null,"pmid":"2690102","source_url":"https://pubmed.ncbi.nlm.nih.gov/2690102/","study_design":null,"title":"Beta-amyloid protein probe hybridized to chromosome 9 in 3 Alzheimer disease individuals","title_match":false,"year":1989},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/multi-dimensional-attention-framework-for-personalised-alzheimer-s-c369392a","doi":"10.21203/rs.3.rs-10309496/v1","journal":"Research Square","n_participants":1669,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10309496/v1","study_design":"longitudinal study","title":"Multi-dimensional attention framework for personalised Alzheimer's disease progression prediction across sporadic and genetic risk cohorts","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/multi-dimensional-attention-framework-for-personalized-alzheimers-f89d89bf","doi":"10.64898/2025.12.13.25342199","journal":"medRxiv","n_participants":1669,"pmid":null,"source_url":"https://doi.org/10.64898/2025.12.13.25342199","study_design":"longitudinal study","title":"Multi-dimensional attention framework for personalized Alzheimer\u2019s disease progression prediction across sporadic and genetic risk cohorts","title_match":true,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/parapsychotic-disorders-in-mentally-handicapped-particularly-in-down-8720368","doi":null,"journal":"Annales medico-psychologiques","n_participants":null,"pmid":"8720368","source_url":"https://pubmed.ncbi.nlm.nih.gov/8720368/","study_design":null,"title":"[Parapsychotic disorders in mentally handicapped (particularly in Down's syndrome)]","title_match":false,"year":1995},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/expanded-ggggcc-hexanucleotide-repeat-in-noncoding-region-of-c9orf72-21944778","doi":"10.1016/j.neuron.2011.09.011","journal":"Neuron","n_participants":null,"pmid":"21944778","source_url":"https://pubmed.ncbi.nlm.nih.gov/21944778/","study_design":null,"title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","title_match":false,"year":2011},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/a-hexanucleotide-repeat-expansion-in-c9orf72-is-the-cause-of-21944779","doi":"10.1016/j.neuron.2011.09.010","journal":"Neuron","n_participants":null,"pmid":"21944779","source_url":"https://pubmed.ncbi.nlm.nih.gov/21944779/","study_design":null,"title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","title_match":false,"year":2011},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/association-of-missense-and-5-splice-site-mutations-in-tau-with-the-9641683","doi":"10.1038/31508","journal":"Nature","n_participants":null,"pmid":"9641683","source_url":"https://pubmed.ncbi.nlm.nih.gov/9641683/","study_design":null,"title":"Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17","title_match":true,"year":1998},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-new-mutation-e46k-of-alpha-synuclein-causes-parkinson-and-lewy-14755719","doi":"10.1002/ana.10795","journal":"Annals of neurology","n_participants":null,"pmid":"14755719","source_url":"https://pubmed.ncbi.nlm.nih.gov/14755719/","study_design":null,"title":"The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia","title_match":false,"year":2004},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/neurodegenerative-tauopathies-11520930","doi":"10.1146/annurev.neuro.24.1.1121","journal":"Annual review of neuroscience","n_participants":null,"pmid":"11520930","source_url":"https://pubmed.ncbi.nlm.nih.gov/11520930/","study_design":null,"title":"Neurodegenerative tauopathies","title_match":false,"year":2001},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/cloning-of-the-gene-containing-mutations-that-cause-park8-linked-15541308","doi":"10.1016/j.neuron.2004.10.023","journal":"Neuron","n_participants":null,"pmid":"15541308","source_url":"https://pubmed.ncbi.nlm.nih.gov/15541308/","study_design":null,"title":"Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease","title_match":false,"year":2004},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/mutations-in-progranulin-cause-tau-negative-frontotemporal-dementia-16862116","doi":"10.1038/nature05016","journal":"Nature","n_participants":null,"pmid":"16862116","source_url":"https://pubmed.ncbi.nlm.nih.gov/16862116/","study_design":null,"title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","title_match":false,"year":2006},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/epidemiology-of-parkinson-s-disease-28150045","doi":"10.1007/s00702-017-1686-y","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"28150045","source_url":"https://pubmed.ncbi.nlm.nih.gov/28150045/","study_design":null,"title":"Epidemiology of Parkinson's disease","title_match":false,"year":2017},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/familial-parkinson-disease-gene-product-parkin-is-a-ubiquitin-protein-10888878","doi":"10.1038/77060","journal":"Nature genetics","n_participants":null,"pmid":"10888878","source_url":"https://pubmed.ncbi.nlm.nih.gov/10888878/","study_design":null,"title":"Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase","title_match":true,"year":2000},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/transmission-and-spreading-of-tauopathy-in-transgenic-mouse-brain-19503072","doi":"10.1038/ncb1901","journal":"Nature cell biology","n_participants":null,"pmid":"19503072","source_url":"https://pubmed.ncbi.nlm.nih.gov/19503072/","study_design":null,"title":"Transmission and spreading of tauopathy in transgenic mouse brain","title_match":false,"year":2009},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/notch3-mutations-in-cadasil-a-hereditary-adult-onset-condition-8878478","doi":"10.1038/383707a0","journal":"Nature","n_participants":null,"pmid":"8878478","source_url":"https://pubmed.ncbi.nlm.nih.gov/8878478/","study_design":null,"title":"Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia","title_match":false,"year":1996},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/phosphorylation-of-ser-129-is-the-dominant-pathological-modification-16847063","doi":"10.1074/jbc.m600933200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16847063","source_url":"https://pubmed.ncbi.nlm.nih.gov/16847063/","study_design":null,"title":"Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease","title_match":true,"year":2006},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/null-mutations-in-progranulin-cause-ubiquitin-positive-frontotemporal-16862115","doi":"10.1038/nature05017","journal":"Nature","n_participants":17,"pmid":"16862115","source_url":"https://pubmed.ncbi.nlm.nih.gov/16862115/","study_design":null,"title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","title_match":false,"year":2006},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/accelerated-in-vitro-fibril-formation-by-a-mutant-alpha-synuclein-9809558","doi":"10.1038/3311","journal":"Nature medicine","n_participants":null,"pmid":"9809558","source_url":"https://pubmed.ncbi.nlm.nih.gov/9809558/","study_design":null,"title":"Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease","title_match":false,"year":1998},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-c9orf72-ggggcc-repeat-is-translated-into-aggregating-dipeptide-23393093","doi":"10.1126/science.1232927","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"23393093","source_url":"https://pubmed.ncbi.nlm.nih.gov/23393093/","study_design":null,"title":"The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/mutation-in-the-tau-gene-in-familial-multiple-system-tauopathy-with-9636220","doi":"10.1073/pnas.95.13.7737","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9636220","source_url":"https://pubmed.ncbi.nlm.nih.gov/9636220/","study_design":null,"title":"Mutation in the tau gene in familial multiple system tauopathy with presenile dementia","title_match":true,"year":1998},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/mutations-in-ubqln2-cause-dominant-x-linked-juvenile-and-adult-onset-21857683","doi":"10.1038/nature10353","journal":"Nature","n_participants":null,"pmid":"21857683","source_url":"https://pubmed.ncbi.nlm.nih.gov/21857683/","study_design":null,"title":"Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia","title_match":false,"year":2011},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tau-pathology-and-neurodegeneration-23684085","doi":"10.1016/s1474-4422(13)70090-5","journal":"The Lancet. Neurology","n_participants":null,"pmid":"23684085","source_url":"https://pubmed.ncbi.nlm.nih.gov/23684085/","study_design":null,"title":"Tau pathology and neurodegeneration","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/rna-toxicity-from-the-als-ftd-c9orf72-expansion-is-mitigated-by-24139042","doi":"10.1016/j.neuron.2013.10.015","journal":"Neuron","n_participants":null,"pmid":"24139042","source_url":"https://pubmed.ncbi.nlm.nih.gov/24139042/","study_design":null,"title":"RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention","title_match":false,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/ggggcc-repeat-expansion-in-c9orf72-compromises-nucleocytoplasmic-26308899","doi":"10.1038/nature14974","journal":"Nature","n_participants":null,"pmid":"26308899","source_url":"https://pubmed.ncbi.nlm.nih.gov/26308899/","study_design":null,"title":"GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/als-associated-fused-in-sarcoma-fus-mutations-disrupt-transportin-20606625","doi":"10.1038/emboj.2010.143","journal":"The EMBO journal","n_participants":null,"pmid":"20606625","source_url":"https://pubmed.ncbi.nlm.nih.gov/20606625/","study_design":null,"title":"ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/tdp-43-is-intrinsically-aggregation-prone-and-amyotrophic-lateral-19465477","doi":"10.1074/jbc.m109.010264","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"19465477","source_url":"https://pubmed.ncbi.nlm.nih.gov/19465477/","study_design":null,"title":"TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity","title_match":false,"year":2009},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/molecular-mechanisms-of-tdp-43-misfolding-and-pathology-in-30837838","doi":"10.3389/fnmol.2019.00025","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"30837838","source_url":"https://pubmed.ncbi.nlm.nih.gov/30837838/","study_design":null,"title":"Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis","title_match":false,"year":2019},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/tau-and-neurodegenerative-disease-the-story-so-far-26635213","doi":"10.1038/nrneurol.2015.225","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"26635213","source_url":"https://pubmed.ncbi.nlm.nih.gov/26635213/","study_design":null,"title":"Tau and neurodegenerative disease: the story so far","title_match":false,"year":2016},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/mutations-in-the-endosomal-escrtiii-complex-subunit-chmp2b-in-16041373","doi":"10.1038/ng1609","journal":"Nature genetics","n_participants":null,"pmid":"16041373","source_url":"https://pubmed.ncbi.nlm.nih.gov/16041373/","study_design":null,"title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","title_match":false,"year":2005},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/premature-polyadenylation-mediated-loss-of-stathmin-2-is-a-hallmark-30643298","doi":"10.1038/s41593-018-0293-z","journal":"Nature neuroscience","n_participants":null,"pmid":"30643298","source_url":"https://pubmed.ncbi.nlm.nih.gov/30643298/","study_design":null,"title":"Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration","title_match":false,"year":2019},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/tardbp-mutations-in-amyotrophic-lateral-sclerosis-with-tdp-43-18396105","doi":"10.1016/s1474-4422(08)70071-1","journal":"The Lancet. Neurology","n_participants":259,"pmid":"18396105","source_url":"https://pubmed.ncbi.nlm.nih.gov/18396105/","study_design":null,"title":"TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis","title_match":false,"year":2008},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-tip-of-the-iceberg-rna-binding-proteins-with-prion-like-domains-22445064","doi":"10.1016/j.brainres.2012.01.016","journal":"Brain research","n_participants":null,"pmid":"22445064","source_url":"https://pubmed.ncbi.nlm.nih.gov/22445064/","study_design":null,"title":"The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease","title_match":false,"year":2012},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/tdp-43-represses-cryptic-exon-inclusion-in-the-ftd-als-gene-unc13a-35197626","doi":"10.1038/s41586-022-04424-7","journal":"Nature","n_participants":null,"pmid":"35197626","source_url":"https://pubmed.ncbi.nlm.nih.gov/35197626/","study_design":null,"title":"TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/tdp-43-mutant-transgenic-mice-develop-features-of-als-and-19833869","doi":"10.1073/pnas.0908767106","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"19833869","source_url":"https://pubmed.ncbi.nlm.nih.gov/19833869/","study_design":null,"title":"TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration","title_match":false,"year":2009},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/a-new-subtype-of-frontotemporal-lobar-degeneration-with-fus-pathology-19674978","doi":"10.1093/brain/awp214","journal":"Brain : a journal of neurology","n_participants":15,"pmid":"19674978","source_url":"https://pubmed.ncbi.nlm.nih.gov/19674978/","study_design":null,"title":"A new subtype of frontotemporal lobar degeneration with FUS pathology","title_match":false,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/targeting-rna-foci-in-ipsc-derived-motor-neurons-from-als-patients-24154603","doi":"10.1126/scitranslmed.3007529","journal":"Science translational medicine","n_participants":null,"pmid":"24154603","source_url":"https://pubmed.ncbi.nlm.nih.gov/24154603/","study_design":null,"title":"Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion","title_match":false,"year":2013},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/parkin-ubiquitinates-the-alpha-synuclein-interacting-protein-11590439","doi":"10.1038/nm1001-1144","journal":"Nature medicine","n_participants":null,"pmid":"11590439","source_url":"https://pubmed.ncbi.nlm.nih.gov/11590439/","study_design":null,"title":"Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease","title_match":false,"year":2001},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-neuropathology-of-traumatic-brain-injury-25702209","doi":"10.1016/b978-0-444-52892-6.00004-0","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"25702209","source_url":"https://pubmed.ncbi.nlm.nih.gov/25702209/","study_design":null,"title":"The neuropathology of traumatic brain injury","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/evidence-of-increased-oxidative-damage-in-both-sporadic-and-familial-9349552","doi":"10.1046/j.1471-4159.1997.69052064.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"9349552","source_url":"https://pubmed.ncbi.nlm.nih.gov/9349552/","study_design":null,"title":"Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis","title_match":true,"year":1997},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-fibrillogenesis-is-nucleation-dependent-implications-10391881","doi":"10.1074/jbc.274.28.19509","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"10391881","source_url":"https://pubmed.ncbi.nlm.nih.gov/10391881/","study_design":null,"title":"alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease","title_match":false,"year":1999},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-alpha-synuclein-transgenic-mice-develop-neuronal-16399671","doi":"10.1523/jneurosci.4308-05.2006","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"16399671","source_url":"https://pubmed.ncbi.nlm.nih.gov/16399671/","study_design":null,"title":"Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death","title_match":false,"year":2006},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/aberrant-cleavage-of-tdp-43-enhances-aggregation-and-cellular-toxicity-19383787","doi":"10.1073/pnas.0900688106","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"19383787","source_url":"https://pubmed.ncbi.nlm.nih.gov/19383787/","study_design":null,"title":"Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity","title_match":false,"year":2009},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/vesicle-permeabilization-by-protofibrillar-alpha-synuclein-11425308","doi":"10.1021/bi0102398","journal":"Biochemistry","n_participants":null,"pmid":"11425308","source_url":"https://pubmed.ncbi.nlm.nih.gov/11425308/","study_design":null,"title":"Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease","title_match":false,"year":2001},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/cytoplasmic-mislocalization-of-tdp-43-is-toxic-to-neurons-and-20071528","doi":"10.1523/jneurosci.4988-09.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"20071528","source_url":"https://pubmed.ncbi.nlm.nih.gov/20071528/","study_design":null,"title":"Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis","title_match":true,"year":2010},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/therapeutic-reduction-of-ataxin-2-extends-lifespan-and-reduces-28405022","doi":"10.1038/nature22038","journal":"Nature","n_participants":null,"pmid":"28405022","source_url":"https://pubmed.ncbi.nlm.nih.gov/28405022/","study_design":null,"title":"Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/tdp-43-transgenic-mice-develop-spastic-paralysis-and-neuronal-20133711","doi":"10.1073/pnas.0912417107","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"20133711","source_url":"https://pubmed.ncbi.nlm.nih.gov/20133711/","study_design":null,"title":"TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/sortilin-mediated-endocytosis-determines-levels-of-the-frontotemporal-21092856","doi":"10.1016/j.neuron.2010.09.034","journal":"Neuron","n_participants":null,"pmid":"21092856","source_url":"https://pubmed.ncbi.nlm.nih.gov/21092856/","study_design":null,"title":"Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/targeted-degradation-of-sense-and-antisense-c9orf72-rna-foci-as-24170860","doi":"10.1073/pnas.1318835110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"24170860","source_url":"https://pubmed.ncbi.nlm.nih.gov/24170860/","study_design":null,"title":"Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration","title_match":false,"year":2013},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/etiology-and-pathogenesis-of-parkinson-s-disease-21626550","doi":"10.1002/mds.23732","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"21626550","source_url":"https://pubmed.ncbi.nlm.nih.gov/21626550/","study_design":null,"title":"Etiology and pathogenesis of Parkinson's disease","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/parkin-mediates-nonclassical-proteasomal-independent-ubiquitination-15728840","doi":"10.1523/jneurosci.4474-04.2005","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"15728840","source_url":"https://pubmed.ncbi.nlm.nih.gov/15728840/","study_design":null,"title":"Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation","title_match":false,"year":2005},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-phenotypic-variability-of-amyotrophic-lateral-sclerosis-25311585","doi":"10.1038/nrneurol.2014.184","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"25311585","source_url":"https://pubmed.ncbi.nlm.nih.gov/25311585/","study_design":null,"title":"The phenotypic variability of amyotrophic lateral sclerosis","title_match":false,"year":2014},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/mutations-in-progranulin-are-a-major-cause-of-ubiquitin-positive-16950801","doi":"10.1093/hmg/ddl241","journal":"Human molecular genetics","n_participants":378,"pmid":"16950801","source_url":"https://pubmed.ncbi.nlm.nih.gov/16950801/","study_design":null,"title":"Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration","title_match":false,"year":2006},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/tau-protein-pathology-in-neurodegenerative-diseases-9786340","doi":"10.1016/s0166-2236(98)01337-x","journal":"Trends in neurosciences","n_participants":null,"pmid":"9786340","source_url":"https://pubmed.ncbi.nlm.nih.gov/9786340/","study_design":null,"title":"Tau protein pathology in neurodegenerative diseases","title_match":false,"year":1998},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/global-analysis-of-tdp-43-interacting-proteins-reveals-strong-20020773","doi":"10.1021/pr901076y","journal":"Journal of proteome research","n_participants":null,"pmid":"20020773","source_url":"https://pubmed.ncbi.nlm.nih.gov/20020773/","study_design":null,"title":"Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/wild-type-human-tdp-43-expression-causes-tdp-43-phosphorylation-20702714","doi":"10.1523/jneurosci.1630-10.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"20702714","source_url":"https://pubmed.ncbi.nlm.nih.gov/20702714/","study_design":null,"title":"Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice","title_match":false,"year":2010},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/neuropathological-changes-in-essential-tremor-33-cases-compared-with-18025031","doi":"10.1093/brain/awm266","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"18025031","source_url":"https://pubmed.ncbi.nlm.nih.gov/18025031/","study_design":"case-control study","title":"Neuropathological changes in essential tremor: 33 cases compared with 21 controls","title_match":false,"year":2007},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tdp-43-in-familial-and-sporadic-frontotemporal-lobar-degeneration-17591968","doi":"10.2353/ajpath.2007.070182","journal":"The American journal of pathology","n_participants":36,"pmid":"17591968","source_url":"https://pubmed.ncbi.nlm.nih.gov/17591968/","study_design":null,"title":"TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions","title_match":true,"year":2007},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/bidirectional-transcripts-of-the-expanded-c9orf72-hexanucleotide-24132570","doi":"10.1007/s00401-013-1189-3","journal":"Acta neuropathologica","n_participants":null,"pmid":"24132570","source_url":"https://pubmed.ncbi.nlm.nih.gov/24132570/","study_design":null,"title":"Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins","title_match":false,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-a53t-alpha-synuclein-mutation-increases-iron-dependent-10934254","doi":"10.1523/jneurosci.20-16-06048.2000","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"10934254","source_url":"https://pubmed.ncbi.nlm.nih.gov/10934254/","study_design":null,"title":"The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity","title_match":false,"year":2000},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-in-amyotrophic-lateral-sclerosis-17945153","doi":"10.1016/s1474-4422(07)70265-x","journal":"The Lancet. Neurology","n_participants":null,"pmid":"17945153","source_url":"https://pubmed.ncbi.nlm.nih.gov/17945153/","study_design":null,"title":"Cognitive impairment in amyotrophic lateral sclerosis","title_match":false,"year":2007},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/controversies-and-priorities-in-amyotrophic-lateral-sclerosis-23415570","doi":"10.1016/s1474-4422(13)70036-x","journal":"The Lancet. Neurology","n_participants":null,"pmid":"23415570","source_url":"https://pubmed.ncbi.nlm.nih.gov/23415570/","study_design":null,"title":"Controversies and priorities in amyotrophic lateral sclerosis","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/binding-of-alpha-synuclein-to-brain-vesicles-is-abolished-by-familial-9756856","doi":"10.1074/jbc.273.41.26292","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"9756856","source_url":"https://pubmed.ncbi.nlm.nih.gov/9756856/","study_design":null,"title":"Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation","title_match":true,"year":1998},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/inhibition-of-heparin-induced-tau-filament-formation-by-15611092","doi":"10.1074/jbc.m408714200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"15611092","source_url":"https://pubmed.ncbi.nlm.nih.gov/15611092/","study_design":null,"title":"Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins","title_match":false,"year":2005},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/genetic-etiology-of-parkinson-disease-associated-with-mutations-in-20506312","doi":"10.1002/humu.21277","journal":"Human mutation","n_participants":null,"pmid":"20506312","source_url":"https://pubmed.ncbi.nlm.nih.gov/20506312/","study_design":null,"title":"Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update","title_match":false,"year":2010},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuropathology-in-mice-expressing-human-alpha-synuclein-10934251","doi":"10.1523/jneurosci.20-16-06021.2000","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"10934251","source_url":"https://pubmed.ncbi.nlm.nih.gov/10934251/","study_design":null,"title":"Neuropathology in mice expressing human alpha-synuclein","title_match":false,"year":2000},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/genome-sequencing-analysis-identifies-new-loci-associated-with-lewy-33589841","doi":"10.1038/s41588-021-00785-3","journal":"Nature genetics","n_participants":null,"pmid":"33589841","source_url":"https://pubmed.ncbi.nlm.nih.gov/33589841/","study_design":null,"title":"Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture","title_match":false,"year":2021},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/mutations-in-the-matrin-3-gene-cause-familial-amyotrophic-lateral-24686783","doi":"10.1038/nn.3688","journal":"Nature neuroscience","n_participants":null,"pmid":"24686783","source_url":"https://pubmed.ncbi.nlm.nih.gov/24686783/","study_design":null,"title":"Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis","title_match":true,"year":2014},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/c9orf72-implicated-in-amytrophic-lateral-sclerosis-and-frontotemporal-24549040","doi":"10.1093/hmg/ddu068","journal":"Human molecular genetics","n_participants":null,"pmid":"24549040","source_url":"https://pubmed.ncbi.nlm.nih.gov/24549040/","study_design":null,"title":"C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/tandem-repeats-mediating-genetic-plasticity-in-health-and-disease-29398703","doi":"10.1038/nrg.2017.115","journal":"Nature reviews. Genetics","n_participants":null,"pmid":"29398703","source_url":"https://pubmed.ncbi.nlm.nih.gov/29398703/","study_design":null,"title":"Tandem repeats mediating genetic plasticity in health and disease","title_match":false,"year":2018},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/interaction-of-fus-and-hdac1-regulates-dna-damage-response-and-repair-24036913","doi":"10.1038/nn.3514","journal":"Nature neuroscience","n_participants":null,"pmid":"24036913","source_url":"https://pubmed.ncbi.nlm.nih.gov/24036913/","study_design":null,"title":"Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons","title_match":false,"year":2013},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-presenilin-hypothesis-of-alzheimer-s-disease-evidence-for-a-loss-17197420","doi":"10.1073/pnas.0608332104","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"17197420","source_url":"https://pubmed.ncbi.nlm.nih.gov/17197420/","study_design":null,"title":"The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism","title_match":true,"year":2007},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/novel-mutations-in-tardbp-tdp-43-in-patients-with-familial-18802454","doi":"10.1371/journal.pgen.1000193","journal":"PLoS genetics","n_participants":296,"pmid":"18802454","source_url":"https://pubmed.ncbi.nlm.nih.gov/18802454/","study_design":null,"title":"Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis","title_match":true,"year":2008},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/mechanisms-of-parkinson-s-disease-linked-to-pathological-alpha-17015225","doi":"10.1016/j.neuron.2006.09.026","journal":"Neuron","n_participants":null,"pmid":"17015225","source_url":"https://pubmed.ncbi.nlm.nih.gov/17015225/","study_design":null,"title":"Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery","title_match":false,"year":2006},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/progranulin-functions-as-a-neurotrophic-factor-to-regulate-neurite-18378771","doi":"10.1083/jcb.200712039","journal":"The Journal of cell biology","n_participants":null,"pmid":"18378771","source_url":"https://pubmed.ncbi.nlm.nih.gov/18378771/","study_design":null,"title":"Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival","title_match":false,"year":2008},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/frontotemporal-dementia-16239184","doi":"10.1016/s1474-4422(05)70223-4","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16239184","source_url":"https://pubmed.ncbi.nlm.nih.gov/16239184/","study_design":null,"title":"Frontotemporal dementia","title_match":false,"year":2005},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/clearance-of-alpha-synuclein-oligomeric-intermediates-via-the-14985429","doi":"10.1523/jneurosci.3809-03.2004","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"14985429","source_url":"https://pubmed.ncbi.nlm.nih.gov/14985429/","study_design":null,"title":"Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway","title_match":false,"year":2004},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/repeat-expansion-diseases-29325606","doi":"10.1016/b978-0-444-63233-3.00009-9","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"29325606","source_url":"https://pubmed.ncbi.nlm.nih.gov/29325606/","study_design":null,"title":"Repeat expansion diseases","title_match":false,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/tau-proteins-with-ftdp-17-mutations-have-a-reduced-ability-to-promote-9824291","doi":"10.1016/s0014-5793(98)01217-4","journal":"FEBS letters","n_participants":null,"pmid":"9824291","source_url":"https://pubmed.ncbi.nlm.nih.gov/9824291/","study_design":null,"title":"Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly","title_match":false,"year":1998},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/gain-and-loss-of-function-of-als-related-mutations-of-tardbp-tdp-43-19959528","doi":"10.1093/hmg/ddp534","journal":"Human molecular genetics","n_participants":null,"pmid":"19959528","source_url":"https://pubmed.ncbi.nlm.nih.gov/19959528/","study_design":null,"title":"Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo","title_match":false,"year":2010},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/pathogenic-implications-of-mutations-in-the-tau-gene-in-pallido-ponto-9789048","doi":"10.1073/pnas.95.22.13103","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9789048","source_url":"https://pubmed.ncbi.nlm.nih.gov/9789048/","study_design":null,"title":"Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17","title_match":false,"year":1998},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/axon-pathology-in-parkinson-s-disease-and-lewy-body-dementia-10557341","doi":"10.1073/pnas.96.23.13450","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10557341","source_url":"https://pubmed.ncbi.nlm.nih.gov/10557341/","study_design":null,"title":"Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein","title_match":false,"year":1999},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/neuropathology-of-frontotemporal-lobar-degeneration-tau-ftld-tau-21720721","doi":"10.1007/s12031-011-9589-0","journal":"Journal of molecular neuroscience : MN","n_participants":null,"pmid":"21720721","source_url":"https://pubmed.ncbi.nlm.nih.gov/21720721/","study_design":null,"title":"Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau)","title_match":false,"year":2011},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/progranulin-mediates-caspase-dependent-cleavage-of-tar-dna-binding-17898224","doi":"10.1523/jneurosci.3421-07.2007","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"17898224","source_url":"https://pubmed.ncbi.nlm.nih.gov/17898224/","study_design":null,"title":"Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43","title_match":false,"year":2007},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/tdp-43-proteinopathies-a-new-wave-of-neurodegenerative-diseases-33177049","doi":"10.1136/jnnp-2020-322983","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"33177049","source_url":"https://pubmed.ncbi.nlm.nih.gov/33177049/","study_design":null,"title":"TDP-43 proteinopathies: a new wave of neurodegenerative diseases","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/mitochondrial-dysfunction-associated-with-increased-oxidative-stress-23039195","doi":"10.1186/1756-6606-5-35","journal":"Molecular brain","n_participants":null,"pmid":"23039195","source_url":"https://pubmed.ncbi.nlm.nih.gov/23039195/","study_design":null,"title":"Mitochondrial dysfunction associated with increased oxidative stress and \u03b1-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue","title_match":false,"year":2012},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/tdp-43-pathology-in-alzheimer-s-disease-34930382","doi":"10.1186/s13024-021-00503-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"34930382","source_url":"https://pubmed.ncbi.nlm.nih.gov/34930382/","study_design":null,"title":"TDP-43 Pathology in Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/genome-wide-association-meta-analysis-of-neuropathologic-features-of-25188341","doi":"10.1371/journal.pgen.1004606","journal":"PLoS genetics","n_participants":null,"pmid":"25188341","source_url":"https://pubmed.ncbi.nlm.nih.gov/25188341/","study_design":null,"title":"Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias","title_match":false,"year":2014},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/u1-small-nuclear-ribonucleoprotein-complex-and-rna-splicing-24023061","doi":"10.1073/pnas.1310249110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"24023061","source_url":"https://pubmed.ncbi.nlm.nih.gov/24023061/","study_design":null,"title":"U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/transgenic-mice-carrying-a-human-mutant-superoxide-dismutase-8610185","doi":"10.1073/pnas.93.7.3155","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8610185","source_url":"https://pubmed.ncbi.nlm.nih.gov/8610185/","study_design":null,"title":"Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions","title_match":false,"year":1996},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-two-faces-of-protein-misfolding-gain-and-loss-of-function-in-18216876","doi":"10.1038/sj.emboj.7601930","journal":"The EMBO journal","n_participants":null,"pmid":"18216876","source_url":"https://pubmed.ncbi.nlm.nih.gov/18216876/","study_design":null,"title":"The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cerebrovascular-dysfunction-and-microcirculation-rarefaction-precede-20071773","doi":"10.1172/jci39733","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"20071773","source_url":"https://pubmed.ncbi.nlm.nih.gov/20071773/","study_design":null,"title":"Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease","title_match":false,"year":2010},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/abnormal-accumulation-of-nacp-alpha-synuclein-in-neurodegenerative-9466562","doi":null,"journal":"The American journal of pathology","n_participants":null,"pmid":"9466562","source_url":"https://pubmed.ncbi.nlm.nih.gov/9466562/","study_design":null,"title":"Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders","title_match":false,"year":1998},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/modeling-parkinson-s-disease-with-the-alpha-synuclein-protein-32390826","doi":"10.3389/fphar.2020.00356","journal":"Frontiers in pharmacology","n_participants":null,"pmid":"32390826","source_url":"https://pubmed.ncbi.nlm.nih.gov/32390826/","study_design":null,"title":"Modeling Parkinson's Disease With the Alpha-Synuclein Protein","title_match":false,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-genetics-and-neuropathology-of-amyotrophic-lateral-sclerosis-22903397","doi":"10.1007/s00401-012-1022-4","journal":"Acta neuropathologica","n_participants":null,"pmid":"22903397","source_url":"https://pubmed.ncbi.nlm.nih.gov/22903397/","study_design":null,"title":"The genetics and neuropathology of amyotrophic lateral sclerosis","title_match":false,"year":2012},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/new-insights-into-the-genetic-etiology-of-alzheimer-s-disease-and-35379992","doi":"10.1038/s41588-022-01024-z","journal":"Nature genetics","n_participants":null,"pmid":"35379992","source_url":"https://pubmed.ncbi.nlm.nih.gov/35379992/","study_design":null,"title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","title_match":false,"year":2022},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/brain-glucose-hypometabolism-and-oxidative-stress-in-preclinical-19076441","doi":"10.1196/annals.1427.007","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"19076441","source_url":"https://pubmed.ncbi.nlm.nih.gov/19076441/","study_design":null,"title":"Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/ferritin-levels-in-the-cerebrospinal-fluid-predict-alzheimer-s-25988319","doi":"10.1038/ncomms7760","journal":"Nature communications","n_participants":null,"pmid":"25988319","source_url":"https://pubmed.ncbi.nlm.nih.gov/25988319/","study_design":"longitudinal study","title":"Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE","title_match":false,"year":2015},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/diverging-longitudinal-changes-in-astrocytosis-and-amyloid-pet-in-26813969","doi":"10.1093/brain/awv404","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"26813969","source_url":"https://pubmed.ncbi.nlm.nih.gov/26813969/","study_design":"longitudinal study","title":"Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease","title_match":true,"year":2016},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tracking-atrophy-progression-in-familial-alzheimer-s-disease-a-serial-16987729","doi":"10.1016/s1474-4422(06)70550-6","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16987729","source_url":"https://pubmed.ncbi.nlm.nih.gov/16987729/","study_design":"cross-sectional","title":"Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study","title_match":true,"year":2006},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/chemogenetic-locus-coeruleus-activation-restores-reversal-learning-in-29053824","doi":"10.1093/brain/awx232","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"29053824","source_url":"https://pubmed.ncbi.nlm.nih.gov/29053824/","study_design":null,"title":"Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/pre-dementia-clinical-stages-in-presenilin-1-e280a-familial-early-21296022","doi":"10.1016/s1474-4422(10)70323-9","journal":"The Lancet. Neurology","n_participants":1784,"pmid":"21296022","source_url":"https://pubmed.ncbi.nlm.nih.gov/21296022/","study_design":null,"title":"Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study","title_match":true,"year":2011},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/diffusion-imaging-changes-in-grey-matter-in-alzheimer-s-disease-a-26136857","doi":"10.1186/s13195-015-0132-3","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"26136857","source_url":"https://pubmed.ncbi.nlm.nih.gov/26136857/","study_design":null,"title":"Diffusion imaging changes in grey matter in Alzheimer's disease: a potential marker of early neurodegeneration","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/effects-of-hypoperfusion-in-alzheimer-s-disease-21971457","doi":"10.3233/jad-2011-0010","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21971457","source_url":"https://pubmed.ncbi.nlm.nih.gov/21971457/","study_design":null,"title":"Effects of hypoperfusion in Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/can-ketones-help-rescue-brain-fuel-supply-in-later-life-implications-27458340","doi":"10.3389/fnmol.2016.00053","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"27458340","source_url":"https://pubmed.ncbi.nlm.nih.gov/27458340/","study_design":null,"title":"Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/fluid-biomarkers-in-alzheimer-s-disease-current-concepts-23800368","doi":"10.1186/1750-1326-8-20","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"23800368","source_url":"https://pubmed.ncbi.nlm.nih.gov/23800368/","study_design":"cross-sectional","title":"Fluid biomarkers in Alzheimer's disease - current concepts","title_match":false,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-a-beta42-is-increased-early-in-sporadic-alzheimer-10211475","doi":"10.1002/1531-8249(199904)45:4<504::aid-ana12>3.0.co;2-9","journal":"Annals of neurology","n_participants":null,"pmid":"10211475","source_url":"https://pubmed.ncbi.nlm.nih.gov/10211475/","study_design":null,"title":"Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression","title_match":false,"year":1999},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/defining-alzheimer-as-a-common-age-related-neurodegenerative-process-22459297","doi":"10.1016/j.pneurobio.2012.03.005","journal":"Progress in neurobiology","n_participants":null,"pmid":"22459297","source_url":"https://pubmed.ncbi.nlm.nih.gov/22459297/","study_design":null,"title":"Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia","title_match":false,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cognitive-frailty-a-systematic-review-of-epidemiological-and-25808052","doi":"10.1089/rej.2014.1637","journal":"Rejuvenation research","n_participants":null,"pmid":"25808052","source_url":"https://pubmed.ncbi.nlm.nih.gov/25808052/","study_design":"systematic review","title":"Cognitive Frailty: A Systematic Review of Epidemiological and Neurobiological Evidence of an Age-Related Clinical Condition","title_match":false,"year":2015},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/predictive-value-of-apoe-4-allele-for-progression-from-mci-to-ad-type-21493755","doi":"10.1136/jnnp.2010.231555","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":35,"pmid":"21493755","source_url":"https://pubmed.ncbi.nlm.nih.gov/21493755/","study_design":"meta-analysis","title":"Predictive value of APOE-\u03b54 allele for progression from MCI to AD-type dementia: a meta-analysis","title_match":false,"year":2011},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/four-subgroups-of-alzheimer-s-disease-based-on-patterns-of-atrophy-16904912","doi":"10.1016/j.neuroimage.2006.06.010","journal":"NeuroImage","n_participants":20,"pmid":"16904912","source_url":"https://pubmed.ncbi.nlm.nih.gov/16904912/","study_design":null,"title":"Four subgroups of Alzheimer's disease based on patterns of atrophy using VBM and a unique pattern for early onset disease","title_match":false,"year":2006},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-prevention-initiative-autosomal-dominant-alzheimer-s-29955659","doi":"10.1016/j.trci.2018.02.002","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":300,"pmid":"29955659","source_url":"https://pubmed.ncbi.nlm.nih.gov/29955659/","study_design":"clinical trial","title":"The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort","title_match":true,"year":2018},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/immunization-with-amyloid-beta-attenuates-alzheimer-disease-like-10408445","doi":"10.1038/22124","journal":"Nature","n_participants":null,"pmid":"10408445","source_url":"https://pubmed.ncbi.nlm.nih.gov/10408445/","study_design":null,"title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","title_match":false,"year":1999},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/two-amyloid-precursor-protein-transgenic-mouse-models-with-alzheimer-9371838","doi":"10.1073/pnas.94.24.13287","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9371838","source_url":"https://pubmed.ncbi.nlm.nih.gov/9371838/","study_design":null,"title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","title_match":false,"year":1997},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/accelerated-alzheimer-type-phenotype-in-transgenic-mice-carrying-both-9427614","doi":"10.1038/nm0198-097","journal":"Nature medicine","n_participants":null,"pmid":"9427614","source_url":"https://pubmed.ncbi.nlm.nih.gov/9427614/","study_design":null,"title":"Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes","title_match":true,"year":1998},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/the-neuronal-sortilin-related-receptor-sorl1-is-genetically-17220890","doi":"10.1038/ng1943","journal":"Nature genetics","n_participants":null,"pmid":"17220890","source_url":"https://pubmed.ncbi.nlm.nih.gov/17220890/","study_design":null,"title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease","title_match":false,"year":2007},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/accelerated-amyloid-deposition-in-the-brains-of-transgenic-mice-9354339","doi":"10.1016/s0896-6273(00)80974-5","journal":"Neuron","n_participants":null,"pmid":"9354339","source_url":"https://pubmed.ncbi.nlm.nih.gov/9354339/","study_design":null,"title":"Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins","title_match":true,"year":1997},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-disease-21045163","doi":"10.1177/0891988710383571","journal":"Journal of geriatric psychiatry and neurology","n_participants":null,"pmid":"21045163","source_url":"https://pubmed.ncbi.nlm.nih.gov/21045163/","study_design":null,"title":"Genetics of Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/trem2-a-key-player-in-microglial-biology-and-alzheimer-disease-30266932","doi":"10.1038/s41582-018-0072-1","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"30266932","source_url":"https://pubmed.ncbi.nlm.nih.gov/30266932/","study_design":null,"title":"TREM2 - a key player in microglial biology and Alzheimer disease","title_match":false,"year":2018},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/neural-stem-cells-improve-cognition-via-bdnf-in-a-transgenic-model-of-19633196","doi":"10.1073/pnas.0901402106","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"19633196","source_url":"https://pubmed.ncbi.nlm.nih.gov/19633196/","study_design":null,"title":"Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/upregulated-function-of-mitochondria-associated-er-membranes-in-22892566","doi":"10.1038/emboj.2012.202","journal":"The EMBO journal","n_participants":null,"pmid":"22892566","source_url":"https://pubmed.ncbi.nlm.nih.gov/22892566/","study_design":null,"title":"Upregulated function of mitochondria-associated ER membranes in Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/beta-secretase-protein-and-activity-are-increased-in-the-neocortex-in-12223024","doi":"10.1001/archneur.59.9.1381","journal":"Archives of neurology","n_participants":null,"pmid":"12223024","source_url":"https://pubmed.ncbi.nlm.nih.gov/12223024/","study_design":null,"title":"Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease","title_match":false,"year":2002},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/early-onset-autosomal-dominant-alzheimer-disease-prevalence-genetic-10441572","doi":"10.1086/302553","journal":"American journal of human genetics","n_participants":100000,"pmid":"10441572","source_url":"https://pubmed.ncbi.nlm.nih.gov/10441572/","study_design":null,"title":"Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum","title_match":true,"year":1999},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/app-psen1-and-psen2-mutations-in-early-onset-alzheimer-disease-a-28350801","doi":"10.1371/journal.pmed.1002270","journal":"PLoS medicine","n_participants":170,"pmid":"28350801","source_url":"https://pubmed.ncbi.nlm.nih.gov/28350801/","study_design":null,"title":"APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases","title_match":true,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-mechanism-of-secretase-dysfunction-in-familial-alzheimer-disease-22505025","doi":"10.1038/emboj.2012.79","journal":"The EMBO journal","n_participants":null,"pmid":"22505025","source_url":"https://pubmed.ncbi.nlm.nih.gov/22505025/","study_design":null,"title":"The mechanism of \u03b3-Secretase dysfunction in familial Alzheimer disease","title_match":true,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/persistent-improvement-in-synaptic-and-cognitive-functions-in-an-15578094","doi":"10.1172/jci22831","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"15578094","source_url":"https://pubmed.ncbi.nlm.nih.gov/15578094/","study_design":null,"title":"Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment","title_match":false,"year":2004},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-e280a-presenilin-1-alzheimer-mutation-produces-increased-a-beta-8837617","doi":"10.1038/nm1096-1146","journal":"Nature medicine","n_participants":null,"pmid":"8837617","source_url":"https://pubmed.ncbi.nlm.nih.gov/8837617/","study_design":null,"title":"The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology","title_match":true,"year":1996},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/relative-abundance-of-alzheimer-a-beta-amyloid-peptide-variants-in-8078890","doi":"10.1073/pnas.91.18.8378","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8078890","source_url":"https://pubmed.ncbi.nlm.nih.gov/8078890/","study_design":null,"title":"Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging","title_match":false,"year":1994},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/episodic-like-memory-deficits-in-the-appswe-ps1de9-mouse-model-of-15755686","doi":"10.1016/j.nbd.2004.10.022","journal":"Neurobiology of disease","n_participants":null,"pmid":"15755686","source_url":"https://pubmed.ncbi.nlm.nih.gov/15755686/","study_design":null,"title":"Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities","title_match":false,"year":2005},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/new-frontiers-in-alzheimer-s-disease-genetics-11683989","doi":"10.1016/s0896-6273(01)00476-7","journal":"Neuron","n_participants":null,"pmid":"11683989","source_url":"https://pubmed.ncbi.nlm.nih.gov/11683989/","study_design":null,"title":"New frontiers in Alzheimer's disease genetics","title_match":false,"year":2001},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/progressive-age-related-development-of-alzheimer-like-pathology-in-15174014","doi":"10.1002/ana.20101","journal":"Annals of neurology","n_participants":null,"pmid":"15174014","source_url":"https://pubmed.ncbi.nlm.nih.gov/15174014/","study_design":null,"title":"Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice","title_match":false,"year":2004},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/participation-of-presenilin-2-in-apoptosis-enhanced-basal-activity-8939861","doi":"10.1126/science.274.5293.1710","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"8939861","source_url":"https://pubmed.ncbi.nlm.nih.gov/8939861/","study_design":null,"title":"Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation","title_match":true,"year":1996},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-presenilin-2-mutation-n141i-linked-to-familial-alzheimer-disease-9050898","doi":"10.1073/pnas.94.5.2025","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9050898","source_url":"https://pubmed.ncbi.nlm.nih.gov/9050898/","study_design":null,"title":"The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue","title_match":true,"year":1997},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-presenilin-1-protein-is-a-component-of-a-high-molecular-weight-9632714","doi":"10.1074/jbc.273.26.16470","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"9632714","source_url":"https://pubmed.ncbi.nlm.nih.gov/9632714/","study_design":null,"title":"The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin","title_match":true,"year":1998},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/loss-of-function-presenilin-mutations-in-alzheimer-disease-talking-17268505","doi":"10.1038/sj.embor.7400897","journal":"EMBO reports","n_participants":null,"pmid":"17268505","source_url":"https://pubmed.ncbi.nlm.nih.gov/17268505/","study_design":null,"title":"Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease","title_match":true,"year":2007},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/estimation-of-the-genetic-contribution-of-presenilin-1-and-2-9384602","doi":"10.1093/hmg/7.1.43","journal":"Human molecular genetics","n_participants":null,"pmid":"9384602","source_url":"https://pubmed.ncbi.nlm.nih.gov/9384602/","study_design":null,"title":"Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease","title_match":true,"year":1998},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/mean-age-of-onset-of-familial-alzheimer-disease-caused-by-presenilin-16752394","doi":"10.1002/humu.20336","journal":"Human mutation","n_participants":null,"pmid":"16752394","source_url":"https://pubmed.ncbi.nlm.nih.gov/16752394/","study_design":null,"title":"Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40","title_match":true,"year":2006},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/amyloid-beta-deposits-lead-to-retinal-degeneration-in-a-mouse-model-18566467","doi":"10.1167/iovs.08-1849","journal":"Investigative ophthalmology & visual science","n_participants":null,"pmid":"18566467","source_url":"https://pubmed.ncbi.nlm.nih.gov/18566467/","study_design":null,"title":"Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/early-changes-in-csf-strem2-in-dominantly-inherited-alzheimer-s-27974666","doi":"10.1126/scitranslmed.aag1767","journal":"Science translational medicine","n_participants":218,"pmid":"27974666","source_url":"https://pubmed.ncbi.nlm.nih.gov/27974666/","study_design":null,"title":"Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury","title_match":true,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/excessive-production-of-amyloid-beta-protein-by-peripheral-cells-of-7991571","doi":"10.1073/pnas.91.25.11993","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7991571","source_url":"https://pubmed.ncbi.nlm.nih.gov/7991571/","study_design":null,"title":"Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation","title_match":true,"year":1994},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/high-frequency-of-potentially-pathogenic-sorl1-mutations-in-autosomal-22472873","doi":"10.1038/mp.2012.15","journal":"Molecular psychiatry","n_participants":null,"pmid":"22472873","source_url":"https://pubmed.ncbi.nlm.nih.gov/22472873/","study_design":null,"title":"High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease","title_match":true,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/physiological-functions-of-app-family-proteins-22355794","doi":"10.1101/cshperspect.a006288","journal":"Cold Spring Harbor perspectives in medicine","n_participants":null,"pmid":"22355794","source_url":"https://pubmed.ncbi.nlm.nih.gov/22355794/","study_design":null,"title":"Physiological functions of APP family proteins","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/dietary-docosahexaenoic-acid-and-docosapentaenoic-acid-ameliorate-17442823","doi":"10.1523/jneurosci.0055-07.2007","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"17442823","source_url":"https://pubmed.ncbi.nlm.nih.gov/17442823/","study_design":null,"title":"Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels","title_match":true,"year":2007},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/generation-of-alzheimer-beta-amyloid-protein-in-the-trans-golgi-9108049","doi":"10.1073/pnas.94.8.3748","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9108049","source_url":"https://pubmed.ncbi.nlm.nih.gov/9108049/","study_design":null,"title":"Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation","title_match":false,"year":1997},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/time-course-of-the-development-of-alzheimer-like-pathology-in-the-11822882","doi":"10.1006/exnr.2001.7754","journal":"Experimental neurology","n_participants":null,"pmid":"11822882","source_url":"https://pubmed.ncbi.nlm.nih.gov/11822882/","study_design":null,"title":"Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse","title_match":false,"year":2002},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/inhibition-of-glycogen-synthase-kinase-3-ameliorates-amyloid-23155049","doi":"10.1074/jbc.m112.409250","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"23155049","source_url":"https://pubmed.ncbi.nlm.nih.gov/23155049/","study_design":null,"title":"Inhibition of glycogen synthase kinase-3 ameliorates \u03b2-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies","title_match":false,"year":2013},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/linkage-and-mutational-analysis-of-familial-alzheimer-disease-1415269","doi":null,"journal":"American journal of human genetics","n_participants":null,"pmid":"1415269","source_url":"https://pubmed.ncbi.nlm.nih.gov/1415269/","study_design":null,"title":"Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region","title_match":true,"year":1992},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/microrna-101-regulates-amyloid-precursor-protein-expression-in-20395292","doi":"10.1074/jbc.m110.112664","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"20395292","source_url":"https://pubmed.ncbi.nlm.nih.gov/20395292/","study_design":null,"title":"MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-disease-linked-mutations-specifically-disrupt-ca2-17431506","doi":"10.1172/jci30447","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"17431506","source_url":"https://pubmed.ncbi.nlm.nih.gov/17431506/","study_design":null,"title":"Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1","title_match":true,"year":2007},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/low-cerebrospinal-fluid-concentration-of-mitochondrial-dna-in-23794434","doi":"10.1002/ana.23955","journal":"Annals of neurology","n_participants":282,"pmid":"23794434","source_url":"https://pubmed.ncbi.nlm.nih.gov/23794434/","study_design":null,"title":"Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/directed-conversion-of-alzheimer-s-disease-patient-skin-fibroblasts-21816272","doi":"10.1016/j.cell.2011.07.007","journal":"Cell","n_participants":null,"pmid":"21816272","source_url":"https://pubmed.ncbi.nlm.nih.gov/21816272/","study_design":null,"title":"Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons","title_match":false,"year":2011},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/age-related-amyloid-beta-deposition-in-transgenic-mice-overexpressing-10880403","doi":"10.1016/s0002-9440(10)64544-0","journal":"The American journal of pathology","n_participants":null,"pmid":"10880403","source_url":"https://pubmed.ncbi.nlm.nih.gov/10880403/","study_design":null,"title":"Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss","title_match":true,"year":2000},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/interaction-between-amyloid-precursor-protein-and-presenilins-in-9223340","doi":"10.1073/pnas.94.15.8208","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9223340","source_url":"https://pubmed.ncbi.nlm.nih.gov/9223340/","study_design":null,"title":"Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease","title_match":false,"year":1997},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/deferoxamine-inhibits-iron-induced-hippocampal-tau-phosphorylation-in-23262393","doi":"10.1016/j.neuint.2012.12.005","journal":"Neurochemistry international","n_participants":null,"pmid":"23262393","source_url":"https://pubmed.ncbi.nlm.nih.gov/23262393/","study_design":null,"title":"Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain","title_match":false,"year":2013},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/associations-between-biomarkers-and-age-in-the-presenilin-1-e280a-25580592","doi":"10.1001/jamaneurol.2014.3314","journal":"JAMA neurology","n_participants":null,"pmid":"25580592","source_url":"https://pubmed.ncbi.nlm.nih.gov/25580592/","study_design":"cross-sectional","title":"Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study","title_match":true,"year":2015},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/intracellular-amyloid-beta-1-42-but-not-extracellular-soluble-amyloid-11861655","doi":"10.1074/jbc.m200887200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"11861655","source_url":"https://pubmed.ncbi.nlm.nih.gov/11861655/","study_design":null,"title":"Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis","title_match":false,"year":2002},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-cerebral-beta-amyloid-angiopathies-hereditary-and-sporadic-16612980","doi":"10.1111/j.1750-3639.2006.tb00559.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"16612980","source_url":"https://pubmed.ncbi.nlm.nih.gov/16612980/","study_design":null,"title":"The cerebral beta-amyloid angiopathies: hereditary and sporadic","title_match":false,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/relationship-between-beta-amyloid-peptide-generating-molecules-and-11689168","doi":"10.1016/s0006-8993(01)03008-6","journal":"Brain research","n_participants":null,"pmid":"11689168","source_url":"https://pubmed.ncbi.nlm.nih.gov/11689168/","study_design":null,"title":"Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain","title_match":false,"year":2001},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/high-striatal-amyloid-beta-peptide-deposition-across-different-20008660","doi":"10.1001/archneurol.2009.285","journal":"Archives of neurology","n_participants":30,"pmid":"20008660","source_url":"https://pubmed.ncbi.nlm.nih.gov/20008660/","study_design":null,"title":"High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types","title_match":false,"year":2009},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/molecular-mechanisms-of-alzheimer-disease-protection-by-the-a673t-25253696","doi":"10.1074/jbc.m114.589069","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"25253696","source_url":"https://pubmed.ncbi.nlm.nih.gov/25253696/","study_design":null,"title":"Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein","title_match":false,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/ferulic-acid-is-a-nutraceutical-secretase-modulator-that-improves-23409038","doi":"10.1371/journal.pone.0055774","journal":"PloS one","n_participants":null,"pmid":"23409038","source_url":"https://pubmed.ncbi.nlm.nih.gov/23409038/","study_design":null,"title":"Ferulic acid is a nutraceutical \u03b2-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice","title_match":false,"year":2013},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/biochemical-markers-in-persons-with-preclinical-familial-alzheimer-18509095","doi":"10.1212/01.wnl.0000303973.71803.81","journal":"Neurology","n_participants":17,"pmid":"18509095","source_url":"https://pubmed.ncbi.nlm.nih.gov/18509095/","study_design":null,"title":"Biochemical markers in persons with preclinical familial Alzheimer disease","title_match":true,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/generation-of-abeta38-and-abeta42-is-independently-and-differentially-17962197","doi":"10.1074/jbc.m708754200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"17962197","source_url":"https://pubmed.ncbi.nlm.nih.gov/17962197/","study_design":null,"title":"Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation","title_match":true,"year":2008},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/proteomic-profiling-of-gamma-secretase-substrates-and-mapping-of-18942891","doi":"10.1371/journal.pbio.0060257","journal":"PLoS biology","n_participants":null,"pmid":"18942891","source_url":"https://pubmed.ncbi.nlm.nih.gov/18942891/","study_design":null,"title":"Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements","title_match":false,"year":2008},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/mutations-of-presenilin-genes-in-dilated-cardiomyopathy-and-heart-17186461","doi":"10.1086/509900","journal":"American journal of human genetics","n_participants":315,"pmid":"17186461","source_url":"https://pubmed.ncbi.nlm.nih.gov/17186461/","study_design":null,"title":"Mutations of presenilin genes in dilated cardiomyopathy and heart failure","title_match":true,"year":2006},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/dna-methylation-of-alzheimer-disease-and-tauopathy-related-genes-in-19606065","doi":"10.1097/nen.0b013e3181af2e46","journal":"Journal of neuropathology and experimental neurology","n_participants":26,"pmid":"19606065","source_url":"https://pubmed.ncbi.nlm.nih.gov/19606065/","study_design":null,"title":"DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain","title_match":false,"year":2009},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/hypoxia-due-to-cardiac-arrest-induces-a-time-dependent-increase-in-22194817","doi":"10.1371/journal.pone.0028263","journal":"PloS one","n_participants":null,"pmid":"22194817","source_url":"https://pubmed.ncbi.nlm.nih.gov/22194817/","study_design":null,"title":"Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid \u03b2 levels in humans","title_match":false,"year":2011},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-seminal-role-of-beta-amyloid-in-the-pathogenesis-of-alzheimer-1605946","doi":"10.1097/00002093-199205000-00003","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"1605946","source_url":"https://pubmed.ncbi.nlm.nih.gov/1605946/","study_design":null,"title":"The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease","title_match":false,"year":1992},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/ryanodine-receptors-physiological-function-and-deregulation-in-24902695","doi":"10.1186/1750-1326-9-21","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"24902695","source_url":"https://pubmed.ncbi.nlm.nih.gov/24902695/","study_design":null,"title":"Ryanodine receptors: physiological function and deregulation in Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/lack-of-tau-proteins-rescues-neuronal-cell-death-and-decreases-23026200","doi":"10.1016/j.ajpath.2012.08.012","journal":"The American journal of pathology","n_participants":null,"pmid":"23026200","source_url":"https://pubmed.ncbi.nlm.nih.gov/23026200/","study_design":null,"title":"Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/intracellular-app-processing-and-a-beta-production-in-alzheimer-10446803","doi":"10.1097/00005072-199908000-00001","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"10446803","source_url":"https://pubmed.ncbi.nlm.nih.gov/10446803/","study_design":null,"title":"Intracellular APP processing and A beta production in Alzheimer disease","title_match":false,"year":1999},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/r47h-variant-of-trem2-associated-with-alzheimer-disease-in-a-large-26076170","doi":"10.1001/jamaneurol.2015.0979","journal":"JAMA neurology","n_participants":751,"pmid":"26076170","source_url":"https://pubmed.ncbi.nlm.nih.gov/26076170/","study_design":null,"title":"R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-familial-dementia-bri2-gene-binds-the-alzheimer-gene-amyloid-beta-15983050","doi":"10.1074/jbc.c500217200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"15983050","source_url":"https://pubmed.ncbi.nlm.nih.gov/15983050/","study_design":null,"title":"The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production","title_match":true,"year":2005},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/presenilin-1-gene-silencing-by-s-adenosylmethionine-a-treatment-for-12706835","doi":"10.1016/s0014-5793(03)00277-1","journal":"FEBS letters","n_participants":null,"pmid":"12706835","source_url":"https://pubmed.ncbi.nlm.nih.gov/12706835/","study_design":null,"title":"Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?","title_match":true,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/causes-and-consequences-of-disturbances-of-cerebral-glucose-14977212","doi":"10.1007/978-1-4419-8969-7_8","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"14977212","source_url":"https://pubmed.ncbi.nlm.nih.gov/14977212/","study_design":null,"title":"Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications","title_match":false,"year":2004},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/high-prevalence-of-pathogenic-mutations-in-patients-with-early-onset-10631141","doi":"10.1086/302702","journal":"American journal of human genetics","n_participants":16,"pmid":"10631141","source_url":"https://pubmed.ncbi.nlm.nih.gov/10631141/","study_design":null,"title":"High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes","title_match":false,"year":2000},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/age-dependent-neurovascular-dysfunction-and-damage-in-a-mouse-model-24781082","doi":"10.1161/strokeaha.114.005179","journal":"Stroke","n_participants":null,"pmid":"24781082","source_url":"https://pubmed.ncbi.nlm.nih.gov/24781082/","study_design":null,"title":"Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy","title_match":false,"year":2014},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/presenilin-mutations-in-familial-alzheimer-disease-and-transgenic-15330337","doi":"10.1093/jnen/63.8.821","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"15330337","source_url":"https://pubmed.ncbi.nlm.nih.gov/15330337/","study_design":null,"title":"Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology","title_match":true,"year":2004},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/data-driven-models-of-dominantly-inherited-alzheimer-s-disease-29579160","doi":"10.1093/brain/awy050","journal":"Brain : a journal of neurology","n_participants":338,"pmid":"29579160","source_url":"https://pubmed.ncbi.nlm.nih.gov/29579160/","study_design":"longitudinal study","title":"Data-driven models of dominantly-inherited Alzheimer's disease progression","title_match":true,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/hyperhomocysteinemia-increases-beta-amyloid-by-enhancing-expression-19264913","doi":"10.2353/ajpath.2009.081036","journal":"The American journal of pathology","n_participants":null,"pmid":"19264913","source_url":"https://pubmed.ncbi.nlm.nih.gov/19264913/","study_design":null,"title":"Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain","title_match":false,"year":2009},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/the-aging-brain-changes-in-the-neuronal-insulin-insulin-receptor-12111436","doi":"10.1007/s007020200082","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"12111436","source_url":"https://pubmed.ncbi.nlm.nih.gov/12111436/","study_design":null,"title":"The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review","title_match":false,"year":2002},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/pathological-and-physiological-functions-of-presenilins-16930451","doi":"10.1186/1750-1326-1-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"16930451","source_url":"https://pubmed.ncbi.nlm.nih.gov/16930451/","study_design":null,"title":"Pathological and physiological functions of presenilins","title_match":false,"year":2006},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/psen2-presenilin-2-mutants-linked-to-familial-alzheimer-disease-30892128","doi":"10.1080/15548627.2019.1596489","journal":"Autophagy","n_participants":null,"pmid":"30892128","source_url":"https://pubmed.ncbi.nlm.nih.gov/30892128/","study_design":null,"title":"PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis","title_match":true,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/acetylated-tau-neuropathology-in-sporadic-and-hereditary-tauopathies-23885714","doi":"10.1016/j.ajpath.2013.04.025","journal":"The American journal of pathology","n_participants":null,"pmid":"23885714","source_url":"https://pubmed.ncbi.nlm.nih.gov/23885714/","study_design":null,"title":"Acetylated tau neuropathology in sporadic and hereditary tauopathies","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/contribution-of-presenilin-transmembrane-domains-6-and-7-to-a-water-16844686","doi":"10.1074/jbc.m604997200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16844686","source_url":"https://pubmed.ncbi.nlm.nih.gov/16844686/","study_design":null,"title":"Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex","title_match":true,"year":2006},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/amino-terminally-truncated-abeta-peptide-species-are-the-main-16086583","doi":"10.1021/bi0508237","journal":"Biochemistry","n_participants":null,"pmid":"16086583","source_url":"https://pubmed.ncbi.nlm.nih.gov/16086583/","study_design":null,"title":"Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques","title_match":false,"year":2005},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/genetic-dissection-of-alzheimer-disease-a-heterogeneous-disorder-7567974","doi":"10.1073/pnas.92.19.8552","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7567974","source_url":"https://pubmed.ncbi.nlm.nih.gov/7567974/","study_design":null,"title":"Genetic dissection of Alzheimer disease, a heterogeneous disorder","title_match":false,"year":1995},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/characterization-of-intermediate-steps-in-amyloid-beta-a-production-24225948","doi":"10.1074/jbc.m113.498246","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"24225948","source_url":"https://pubmed.ncbi.nlm.nih.gov/24225948/","study_design":null,"title":"Characterization of intermediate steps in amyloid beta (A\u03b2) production under near-native conditions","title_match":false,"year":2014},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/nfkappab-dependent-control-of-bace1-promoter-transactivation-by-18263584","doi":"10.1074/jbc.m706579200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"18263584","source_url":"https://pubmed.ncbi.nlm.nih.gov/18263584/","study_design":null,"title":"NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/tannic-acid-is-a-natural-secretase-inhibitor-that-prevents-cognitive-22219198","doi":"10.1074/jbc.m111.294025","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"22219198","source_url":"https://pubmed.ncbi.nlm.nih.gov/22219198/","study_design":null,"title":"Tannic acid is a natural \u03b2-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice","title_match":false,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/high-systolic-blood-pressure-induces-cerebral-microvascular-30571552","doi":"10.1161/hypertensionaha.118.12048","journal":"Hypertension (Dallas, Tex. : 1979)","n_participants":null,"pmid":"30571552","source_url":"https://pubmed.ncbi.nlm.nih.gov/30571552/","study_design":null,"title":"High Systolic Blood Pressure Induces Cerebral Microvascular Endothelial Dysfunction, Neurovascular Unit Damage, and Cognitive Decline in Mice","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cholesterol-impairs-autophagy-mediated-clearance-of-amyloid-beta-29862881","doi":"10.1080/15548627.2018.1438807","journal":"Autophagy","n_participants":null,"pmid":"29862881","source_url":"https://pubmed.ncbi.nlm.nih.gov/29862881/","study_design":null,"title":"Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/intracellular-amyloid-and-the-neuronal-origin-of-alzheimer-neuritic-25092575","doi":"10.1016/j.nbd.2014.07.011","journal":"Neurobiology of disease","n_participants":null,"pmid":"25092575","source_url":"https://pubmed.ncbi.nlm.nih.gov/25092575/","study_design":null,"title":"Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques","title_match":false,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-specific-variants-in-the-3-utr-of-amyloid-precursor-protein-21982160","doi":"10.1186/1750-1326-6-70","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"21982160","source_url":"https://pubmed.ncbi.nlm.nih.gov/21982160/","study_design":null,"title":"Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function","title_match":false,"year":2011},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/identification-of-a-new-presenilin-dependent-zeta-cleavage-site-15485850","doi":"10.1074/jbc.c400473200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"15485850","source_url":"https://pubmed.ncbi.nlm.nih.gov/15485850/","study_design":null,"title":"Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein","title_match":true,"year":2004},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/neuregulin-1-and-erbb4-immunoreactivity-is-associated-with-neuritic-12528817","doi":"10.1093/jnen/62.1.42","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"12528817","source_url":"https://pubmed.ncbi.nlm.nih.gov/12528817/","study_design":null,"title":"Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease","title_match":false,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/pomegranate-polyphenols-and-extract-inhibit-nuclear-factor-of-23468550","doi":"10.3945/jn.112.169516","journal":"The Journal of nutrition","n_participants":null,"pmid":"23468550","source_url":"https://pubmed.ncbi.nlm.nih.gov/23468550/","study_design":null,"title":"Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/proteomic-changes-in-cerebrospinal-fluid-of-presymptomatic-and-22232349","doi":"10.1001/archneurol.2011.642","journal":"Archives of neurology","n_participants":null,"pmid":"22232349","source_url":"https://pubmed.ncbi.nlm.nih.gov/22232349/","study_design":null,"title":"Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations","title_match":true,"year":2012},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/caloric-restriction-attenuates-amyloid-deposition-in-middle-aged-dtg-19699265","doi":"10.1016/j.neulet.2009.08.038","journal":"Neuroscience letters","n_participants":null,"pmid":"19699265","source_url":"https://pubmed.ncbi.nlm.nih.gov/19699265/","study_design":null,"title":"Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice","title_match":false,"year":2009},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/dna-synthesis-and-neuronal-apoptosis-caused-by-familial-alzheimer-12890786","doi":"10.1523/jneurosci.23-17-06914.2003","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"12890786","source_url":"https://pubmed.ncbi.nlm.nih.gov/12890786/","study_design":null,"title":"DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3","title_match":true,"year":2003},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/leveraging-preclinical-models-for-the-development-of-alzheimer-32612262","doi":"10.1038/s41573-020-0065-9","journal":"Nature reviews. Drug discovery","n_participants":null,"pmid":"32612262","source_url":"https://pubmed.ncbi.nlm.nih.gov/32612262/","study_design":null,"title":"Leveraging preclinical models for the development of Alzheimer disease therapeutics","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/lactate-deficit-in-an-alzheimer-disease-mouse-model-the-relationship-30383244","doi":"10.1093/jnen/nly102","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"30383244","source_url":"https://pubmed.ncbi.nlm.nih.gov/30383244/","study_design":null,"title":"Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cathepsin-b-degrades-amyloid-in-mice-expressing-wild-type-human-23024364","doi":"10.1074/jbc.m112.371641","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"23024364","source_url":"https://pubmed.ncbi.nlm.nih.gov/23024364/","study_design":null,"title":"Cathepsin B degrades amyloid-\u03b2 in mice expressing wild-type human amyloid precursor protein","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/bri2-interacts-with-amyloid-precursor-protein-app-and-regulates-16027166","doi":"10.1074/jbc.c500231200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16027166","source_url":"https://pubmed.ncbi.nlm.nih.gov/16027166/","study_design":null,"title":"BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production","title_match":false,"year":2005},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-french-series-of-autosomal-dominant-early-onset-alzheimer-s-22475797","doi":"10.3233/jad-2012-120172","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"22475797","source_url":"https://pubmed.ncbi.nlm.nih.gov/22475797/","study_design":null,"title":"The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers","title_match":true,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/s-adenosylmethionine-reduces-the-progress-of-the-alzheimer-like-22221883","doi":"10.1016/j.neurobiolaging.2011.12.013","journal":"Neurobiology of aging","n_participants":null,"pmid":"22221883","source_url":"https://pubmed.ncbi.nlm.nih.gov/22221883/","study_design":null,"title":"S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/crucial-role-of-calbindin-d28k-in-the-pathogenesis-of-alzheimer-s-24853300","doi":"10.1038/cdd.2014.67","journal":"Cell death and differentiation","n_participants":null,"pmid":"24853300","source_url":"https://pubmed.ncbi.nlm.nih.gov/24853300/","study_design":null,"title":"Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model","title_match":false,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/distinct-patterns-of-app-processing-in-the-cns-in-autosomal-dominant-23224319","doi":"10.1007/s00401-012-1062-9","journal":"Acta neuropathologica","n_participants":18,"pmid":"23224319","source_url":"https://pubmed.ncbi.nlm.nih.gov/23224319/","study_design":null,"title":"Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/novel-presenilin-1-mutation-s170f-causing-alzheimer-disease-with-lewy-16344340","doi":"10.1001/archneur.62.12.1821","journal":"Archives of neurology","n_participants":null,"pmid":"16344340","source_url":"https://pubmed.ncbi.nlm.nih.gov/16344340/","study_design":null,"title":"Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life","title_match":true,"year":2005},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/analysis-of-the-5-sequence-genomic-structure-and-alternative-splicing-9073509","doi":"10.1006/geno.1996.4523","journal":"Genomics","n_participants":null,"pmid":"9073509","source_url":"https://pubmed.ncbi.nlm.nih.gov/9073509/","study_design":null,"title":"Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease","title_match":true,"year":1997},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/nicastrin-is-critical-for-stability-and-trafficking-but-not-15711015","doi":"10.1074/jbc.m409467200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"15711015","source_url":"https://pubmed.ncbi.nlm.nih.gov/15711015/","study_design":null,"title":"Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components","title_match":true,"year":2005},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/c9orf72-hexanucleotide-repeat-expansions-in-clinical-alzheimer-disease-23588422","doi":"10.1001/2013.jamaneurol.537","journal":"JAMA neurology","n_participants":null,"pmid":"23588422","source_url":"https://pubmed.ncbi.nlm.nih.gov/23588422/","study_design":"case-control study","title":"C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/neuropathology-of-autosomal-dominant-alzheimer-disease-in-the-26888304","doi":"10.1093/jnen/nlv028","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"26888304","source_url":"https://pubmed.ncbi.nlm.nih.gov/26888304/","study_design":null,"title":"Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database","title_match":true,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/structure-dependent-impairment-of-intracellular-apolipoprotein-e4-21454574","doi":"10.1074/jbc.m110.217380","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"21454574","source_url":"https://pubmed.ncbi.nlm.nih.gov/21454574/","study_design":null,"title":"Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors","title_match":false,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gamma-secretase-substrate-concentration-modulates-the-abeta42-abeta40-17556361","doi":"10.1074/jbc.m704601200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"17556361","source_url":"https://pubmed.ncbi.nlm.nih.gov/17556361/","study_design":null,"title":"{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE","title_match":false,"year":2007},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/genome-instability-in-alzheimer-disease-27105872","doi":"10.1016/j.mad.2016.04.005","journal":"Mechanisms of ageing and development","n_participants":null,"pmid":"27105872","source_url":"https://pubmed.ncbi.nlm.nih.gov/27105872/","study_design":null,"title":"Genome instability in Alzheimer disease","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/induced-dimerization-of-the-amyloid-precursor-protein-leads-to-19596858","doi":"10.1074/jbc.m109.038646","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"19596858","source_url":"https://pubmed.ncbi.nlm.nih.gov/19596858/","study_design":null,"title":"Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production","title_match":false,"year":2009},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/amyloid-beta-deposition-is-associated-with-decreased-hippocampal-15198121","doi":"10.1093/jnen/63.5.418","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"15198121","source_url":"https://pubmed.ncbi.nlm.nih.gov/15198121/","study_design":null,"title":"Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice","title_match":false,"year":2004},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/a-sensitive-and-quantitative-assay-for-measuring-cleavage-of-11744687","doi":"10.1074/jbc.c100649200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"11744687","source_url":"https://pubmed.ncbi.nlm.nih.gov/11744687/","study_design":null,"title":"A sensitive and quantitative assay for measuring cleavage of presenilin substrates","title_match":true,"year":2002},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/seizures-in-dominantly-inherited-alzheimer-disease-27466472","doi":"10.1212/wnl.0000000000003048","journal":"Neurology","n_participants":132,"pmid":"27466472","source_url":"https://pubmed.ncbi.nlm.nih.gov/27466472/","study_design":null,"title":"Seizures in dominantly inherited Alzheimer disease","title_match":true,"year":2016},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/secretase-modulator-gsm-photoaffinity-probes-reveal-distinct-23396974","doi":"10.1074/jbc.m112.398602","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"23396974","source_url":"https://pubmed.ncbi.nlm.nih.gov/23396974/","study_design":null,"title":"\u03b3-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin","title_match":true,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/clinical-and-neuropathological-features-of-the-arctic-app-gene-18413473","doi":"10.1001/archneur.65.4.499","journal":"Archives of neurology","n_participants":null,"pmid":"18413473","source_url":"https://pubmed.ncbi.nlm.nih.gov/18413473/","study_design":null,"title":"Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-risk-genes-and-mechanisms-of-disease-pathogenesis-24951455","doi":"10.1016/j.biopsych.2014.05.006","journal":"Biological psychiatry","n_participants":null,"pmid":"24951455","source_url":"https://pubmed.ncbi.nlm.nih.gov/24951455/","study_design":null,"title":"Alzheimer's disease risk genes and mechanisms of disease pathogenesis","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/mutations-in-two-genes-encoding-different-subunits-of-a-receptor-12080485","doi":"10.1086/342259","journal":"American journal of human genetics","n_participants":null,"pmid":"12080485","source_url":"https://pubmed.ncbi.nlm.nih.gov/12080485/","study_design":null,"title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype","title_match":false,"year":2002},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/late-onset-alzheimer-s-disease-genetics-implicates-microglial-28549481","doi":"10.1186/s13024-017-0184-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"28549481","source_url":"https://pubmed.ncbi.nlm.nih.gov/28549481/","study_design":null,"title":"Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk","title_match":false,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/disease-progression-dependent-effects-of-trem2-deficiency-in-a-mouse-28100745","doi":"10.1523/jneurosci.2110-16.2016","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"28100745","source_url":"https://pubmed.ncbi.nlm.nih.gov/28100745/","study_design":null,"title":"Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/immune-signaling-in-neurodegeneration-30995509","doi":"10.1016/j.immuni.2019.03.016","journal":"Immunity","n_participants":null,"pmid":"30995509","source_url":"https://pubmed.ncbi.nlm.nih.gov/30995509/","study_design":null,"title":"Immune Signaling in Neurodegeneration","title_match":false,"year":2019},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/galectin-3-a-novel-endogenous-trem2-ligand-detrimentally-regulates-31006066","doi":"10.1007/s00401-019-02013-z","journal":"Acta neuropathologica","n_participants":null,"pmid":"31006066","source_url":"https://pubmed.ncbi.nlm.nih.gov/31006066/","study_design":null,"title":"Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/dap12-trem2-deficiency-results-in-impaired-osteoclast-differentiation-12925681","doi":"10.1084/jem.20030027","journal":"The Journal of experimental medicine","n_participants":null,"pmid":"12925681","source_url":"https://pubmed.ncbi.nlm.nih.gov/12925681/","study_design":null,"title":"DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features","title_match":false,"year":2003},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/a-genome-wide-gene-expression-analysis-and-database-in-transgenic-25620700","doi":"10.1016/j.celrep.2014.12.041","journal":"Cell reports","n_participants":null,"pmid":"25620700","source_url":"https://pubmed.ncbi.nlm.nih.gov/25620700/","study_design":null,"title":"A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/molecular-basis-of-familial-and-sporadic-alzheimer-s-disease-26971934","doi":"10.2174/1567205013666160314150501","journal":"Current Alzheimer research","n_participants":null,"pmid":"26971934","source_url":"https://pubmed.ncbi.nlm.nih.gov/26971934/","study_design":null,"title":"Molecular Basis of Familial and Sporadic Alzheimer's Disease","title_match":true,"year":2016},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/genetic-variations-underlying-alzheimer-s-disease-evidence-from-27302364","doi":"10.1016/s1474-4422(16)00127-7","journal":"The Lancet. Neurology","n_participants":null,"pmid":"27302364","source_url":"https://pubmed.ncbi.nlm.nih.gov/27302364/","study_design":null,"title":"Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond","title_match":false,"year":2016},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/essential-role-of-the-microglial-triggering-receptor-expressed-on-17239445","doi":"10.1016/j.jneuroim.2006.11.032","journal":"Journal of neuroimmunology","n_participants":null,"pmid":"17239445","source_url":"https://pubmed.ncbi.nlm.nih.gov/17239445/","study_design":null,"title":"Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis","title_match":false,"year":2007},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/endo-lysosomal-dysregulations-and-late-onset-alzheimer-s-disease-31159836","doi":"10.1186/s13024-019-0323-7","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31159836","source_url":"https://pubmed.ncbi.nlm.nih.gov/31159836/","study_design":null,"title":"Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors","title_match":true,"year":2019},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-proteomics-in-patients-with-alzheimer-s-disease-38195725","doi":"10.1038/s43587-023-00550-7","journal":"Nature aging","n_participants":419,"pmid":"38195725","source_url":"https://pubmed.ncbi.nlm.nih.gov/38195725/","study_design":null,"title":"Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles","title_match":true,"year":2024},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/the-genetic-causes-of-basal-ganglia-calcification-dementia-and-bone-15883308","doi":"10.1212/01.wnl.0000160304.00003.ca","journal":"Neurology","n_participants":null,"pmid":"15883308","source_url":"https://pubmed.ncbi.nlm.nih.gov/15883308/","study_design":null,"title":"The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2","title_match":false,"year":2005},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-substrate-repertoire-of-secretase-presenilin-32616437","doi":"10.1016/j.semcdb.2020.05.019","journal":"Seminars in cell & developmental biology","n_participants":null,"pmid":"32616437","source_url":"https://pubmed.ncbi.nlm.nih.gov/32616437/","study_design":null,"title":"The substrate repertoire of \u03b3-secretase/presenilin","title_match":true,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/white-matter-diffusion-alterations-precede-symptom-onset-in-autosomal-30239611","doi":"10.1093/brain/awy229","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"30239611","source_url":"https://pubmed.ncbi.nlm.nih.gov/30239611/","study_design":null,"title":"White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease","title_match":true,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-metabolism-and-functions-in-brain-and-its-role-in-27922847","doi":"10.1097/mol.0000000000000383","journal":"Current opinion in lipidology","n_participants":null,"pmid":"27922847","source_url":"https://pubmed.ncbi.nlm.nih.gov/27922847/","study_design":null,"title":"Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-genetics-of-alzheimer-s-disease-24729694","doi":"10.2147/cia.s51571","journal":"Clinical interventions in aging","n_participants":null,"pmid":"24729694","source_url":"https://pubmed.ncbi.nlm.nih.gov/24729694/","study_design":null,"title":"The genetics of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/phospholipids-of-apoe-lipoproteins-activate-microglia-in-an-isoform-34099706","doi":"10.1038/s41467-021-23762-0","journal":"Nature communications","n_participants":null,"pmid":"34099706","source_url":"https://pubmed.ncbi.nlm.nih.gov/34099706/","study_design":null,"title":"Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/proteomics-of-brain-csf-and-plasma-identifies-molecular-signatures-37406134","doi":"10.1126/scitranslmed.abq5923","journal":"Science translational medicine","n_participants":null,"pmid":"37406134","source_url":"https://pubmed.ncbi.nlm.nih.gov/37406134/","study_design":null,"title":"Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/multi-omics-analysis-of-microglial-extracellular-vesicles-from-human-34925024","doi":"10.3389/fphar.2021.766082","journal":"Frontiers in pharmacology","n_participants":null,"pmid":"34925024","source_url":"https://pubmed.ncbi.nlm.nih.gov/34925024/","study_design":null,"title":"Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-effect-of-increased-genetic-risk-for-alzheimer-s-disease-on-26973105","doi":"10.1016/j.neurobiolaging.2015.12.023","journal":"Neurobiology of aging","n_participants":null,"pmid":"26973105","source_url":"https://pubmed.ncbi.nlm.nih.gov/26973105/","study_design":"case-control study","title":"The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume","title_match":true,"year":2016},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/assessing-the-role-of-the-trem2-p-r47h-variant-as-a-risk-factor-for-24041969","doi":"10.1016/j.neurobiolaging.2013.08.011","journal":"Neurobiology of aging","n_participants":32598,"pmid":"24041969","source_url":"https://pubmed.ncbi.nlm.nih.gov/24041969/","study_design":"meta-analysis","title":"Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/dap12-and-trem2-molecules-involved-in-innate-immunity-and-15686960","doi":"10.1016/j.nbd.2004.09.007","journal":"Neurobiology of disease","n_participants":null,"pmid":"15686960","source_url":"https://pubmed.ncbi.nlm.nih.gov/15686960/","study_design":null,"title":"Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS","title_match":false,"year":2005},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-trem2-dap12-signaling-pathway-in-nasu-hakola-disease-a-molecular-26478868","doi":"10.2147/rrbc.s58057","journal":"Research and reports in biochemistry","n_participants":null,"pmid":"26478868","source_url":"https://pubmed.ncbi.nlm.nih.gov/26478868/","study_design":null,"title":"The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/impact-of-trem2-risk-variants-on-brain-region-specific-immune-31350575","doi":"10.1007/s00401-019-02048-2","journal":"Acta neuropathologica","n_participants":null,"pmid":"31350575","source_url":"https://pubmed.ncbi.nlm.nih.gov/31350575/","study_design":null,"title":"Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/csf-progranulin-increases-in-the-course-of-alzheimer-s-disease-and-is-30482868","doi":"10.15252/emmm.201809712","journal":"EMBO molecular medicine","n_participants":null,"pmid":"30482868","source_url":"https://pubmed.ncbi.nlm.nih.gov/30482868/","study_design":null,"title":"CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline","title_match":false,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/functional-characterization-of-alzheimer-s-disease-genetic-variants-37735198","doi":"10.1038/s41588-023-01506-8","journal":"Nature genetics","n_participants":null,"pmid":"37735198","source_url":"https://pubmed.ncbi.nlm.nih.gov/37735198/","study_design":null,"title":"Functional characterization of Alzheimer's disease genetic variants in microglia","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/shifting-paradigms-the-central-role-of-microglia-in-alzheimer-s-32535152","doi":"10.1016/j.nbd.2020.104962","journal":"Neurobiology of disease","n_participants":null,"pmid":"32535152","source_url":"https://pubmed.ncbi.nlm.nih.gov/32535152/","study_design":null,"title":"Shifting paradigms: The central role of microglia in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/trem2-in-alzheimer-s-disease-microglial-survival-and-energy-metabolism-30532704","doi":"10.3389/fnagi.2018.00395","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"30532704","source_url":"https://pubmed.ncbi.nlm.nih.gov/30532704/","study_design":null,"title":"TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism","title_match":false,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/knock-in-models-related-to-alzheimer-s-disease-synaptic-transmission-34266459","doi":"10.1186/s13024-021-00457-0","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"34266459","source_url":"https://pubmed.ncbi.nlm.nih.gov/34266459/","study_design":null,"title":"Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/tyrobp-genetic-variants-in-early-onset-alzheimer-s-disease-27658901","doi":"10.1016/j.neurobiolaging.2016.07.028","journal":"Neurobiology of aging","n_participants":null,"pmid":"27658901","source_url":"https://pubmed.ncbi.nlm.nih.gov/27658901/","study_design":null,"title":"TYROBP genetic variants in early-onset Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/higher-csf-strem2-attenuates-apoe4-related-risk-for-cognitive-decline-33032659","doi":"10.1186/s13024-020-00407-2","journal":"Molecular neurodegeneration","n_participants":221,"pmid":"33032659","source_url":"https://pubmed.ncbi.nlm.nih.gov/33032659/","study_design":"longitudinal study","title":"Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/integrative-approach-to-sporadic-alzheimer-s-disease-deficiency-of-30283032","doi":"10.1038/s41380-018-0255-6","journal":"Molecular psychiatry","n_participants":null,"pmid":"30283032","source_url":"https://pubmed.ncbi.nlm.nih.gov/30283032/","study_design":null,"title":"Integrative approach to sporadic Alzheimer's disease:\u00a0deficiency of TYROBP\u00a0in cerebral A\u03b2 amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing A\u03b2 burden","title_match":false,"year":2019},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/trem2-deficiency-differentially-affects-phenotype-and-transcriptome-32703241","doi":"10.1186/s13024-020-00394-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"32703241","source_url":"https://pubmed.ncbi.nlm.nih.gov/32703241/","study_design":null,"title":"Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice","title_match":false,"year":2020},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/investigation-of-trem2-pld3-and-unc5c-variants-in-patients-with-24866402","doi":"10.1016/j.neurobiolaging.2014.04.025","journal":"Neurobiology of aging","n_participants":360,"pmid":"24866402","source_url":"https://pubmed.ncbi.nlm.nih.gov/24866402/","study_design":null,"title":"Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China","title_match":false,"year":2014},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/microglial-trem2-induces-synaptic-impairment-at-early-stage-and-31219699","doi":"10.1096/fj.201900527r","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"31219699","source_url":"https://pubmed.ncbi.nlm.nih.gov/31219699/","study_design":null,"title":"Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice","title_match":false,"year":2019},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/a-trem2-sup-r47h-sup-mouse-model-without-cryptic-splicing-drives-age-36803190","doi":"10.1186/s13024-023-00598-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"36803190","source_url":"https://pubmed.ncbi.nlm.nih.gov/36803190/","study_design":null,"title":"A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/association-of-rare-coding-mutations-with-alzheimer-disease-and-other-30924900","doi":"10.1001/jamanetworkopen.2019.1350","journal":"JAMA network open","n_participants":5617,"pmid":"30924900","source_url":"https://pubmed.ncbi.nlm.nih.gov/30924900/","study_design":null,"title":"Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry","title_match":false,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/uncovering-disease-mechanisms-in-a-novel-mouse-model-expressing-34707490","doi":"10.3389/fnagi.2021.735524","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"34707490","source_url":"https://pubmed.ncbi.nlm.nih.gov/34707490/","study_design":"cross-sectional","title":"Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOE\u03b54 and Trem2*R47H","title_match":false,"year":2021},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/early-onset-alzheimer-disease-and-candidate-risk-genes-involved-in-28738127","doi":"10.1001/jamaneurol.2017.1518","journal":"JAMA neurology","n_participants":null,"pmid":"28738127","source_url":"https://pubmed.ncbi.nlm.nih.gov/28738127/","study_design":"case-control study","title":"Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/nasu-hakola-disease-the-first-case-reported-by-nasu-and-review-the-20500450","doi":"10.1111/j.1440-1789.2010.01127.x","journal":"Neuropathology : official journal of the Japanese Society of Neuropathology","n_participants":null,"pmid":"20500450","source_url":"https://pubmed.ncbi.nlm.nih.gov/20500450/","study_design":null,"title":"Nasu-Hakola disease: The first case reported by Nasu and review: The 50th Anniversary of Japanese Society of Neuropathology","title_match":false,"year":2010},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/a-novel-systems-biology-approach-to-evaluate-mouse-models-of-late-33172468","doi":"10.1186/s13024-020-00412-5","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"33172468","source_url":"https://pubmed.ncbi.nlm.nih.gov/33172468/","study_design":"cohort study","title":"A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/analysis-of-50-neurodegenerative-genes-in-clinically-diagnosed-early-30917570","doi":"10.3390/ijms20061514","journal":"International journal of molecular sciences","n_participants":null,"pmid":"30917570","source_url":"https://pubmed.ncbi.nlm.nih.gov/30917570/","study_design":null,"title":"Analysis of 50 Neurodegenerative Genes in Clinically Diagnosed Early-Onset Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/gene-co-expression-networks-identify-trem2-and-tyrobp-as-major-hubs-28502803","doi":"10.1016/j.nbd.2017.05.006","journal":"Neurobiology of disease","n_participants":null,"pmid":"28502803","source_url":"https://pubmed.ncbi.nlm.nih.gov/28502803/","study_design":null,"title":"Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury","title_match":false,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/sod1-in-cerebral-spinal-fluid-as-a-pharmacodynamic-marker-for-23147550","doi":"10.1001/jamaneurol.2013.593","journal":"JAMA neurology","n_participants":null,"pmid":"23147550","source_url":"https://pubmed.ncbi.nlm.nih.gov/23147550/","study_design":null,"title":"SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy","title_match":false,"year":2013},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/emerging-cerebrospinal-fluid-biomarkers-in-autosomal-dominant-30846386","doi":"10.1016/j.jalz.2018.12.019","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":235,"pmid":"30846386","source_url":"https://pubmed.ncbi.nlm.nih.gov/30846386/","study_design":null,"title":"Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/gamma-secretase-dependent-amyloid-beta-is-increased-in-niemann-pick-21205675","doi":"10.1212/wnl.0b013e318208f4ab","journal":"Neurology","n_participants":38,"pmid":"21205675","source_url":"https://pubmed.ncbi.nlm.nih.gov/21205675/","study_design":null,"title":"Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study","title_match":false,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/allosteric-modulation-of-ps1-gamma-secretase-conformation-correlates-19924286","doi":"10.1371/journal.pone.0007893","journal":"PloS one","n_participants":null,"pmid":"19924286","source_url":"https://pubmed.ncbi.nlm.nih.gov/19924286/","study_design":null,"title":"Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio","title_match":false,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/total-tau-and-phosphorylated-tau-181-levels-in-the-cerebrospinal-12975285","doi":"10.1001/archneur.60.9.1209","journal":"Archives of neurology","n_participants":18,"pmid":"12975285","source_url":"https://pubmed.ncbi.nlm.nih.gov/12975285/","study_design":"case-control study","title":"Total tau and phosphorylated tau 181 levels in the cerebrospinal fluid of patients with frontotemporal dementia due to P301L and G272V tau mutations","title_match":false,"year":2003},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/intermediate-flortaucipir-uptake-is-associated-with-a-pet-and-csf-tau-32015176","doi":"10.1212/wnl.0000000000008905","journal":"Neurology","n_participants":null,"pmid":"32015176","source_url":"https://pubmed.ncbi.nlm.nih.gov/32015176/","study_design":null,"title":"Intermediate flortaucipir uptake is associated with A\u03b2-PET and CSF tau in asymptomatic adults","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cardiorespiratory-fitness-alters-the-influence-of-a-polygenic-risk-28341646","doi":"10.1212/wnl.0000000000003862","journal":"Neurology","n_participants":null,"pmid":"28341646","source_url":"https://pubmed.ncbi.nlm.nih.gov/28341646/","study_design":"cross-sectional","title":"Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD","title_match":true,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/interactions-between-apolipoprotein-e-sex-and-amyloid-beta-on-36041266","doi":"10.1016/j.ebiom.2022.104241","journal":"EBioMedicine","n_participants":null,"pmid":"36041266","source_url":"https://pubmed.ncbi.nlm.nih.gov/36041266/","study_design":"cohort study","title":"Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)","title_match":false,"year":2022},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/csf-tau-phosphorylation-at-thr205-is-associated-with-loss-of-white-35358703","doi":"10.1016/j.nbd.2022.105714","journal":"Neurobiology of disease","n_participants":null,"pmid":"35358703","source_url":"https://pubmed.ncbi.nlm.nih.gov/35358703/","study_design":null,"title":"CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease","title_match":true,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/grief-and-economic-stressors-by-sex-gender-and-education-associations-40163795","doi":"10.1212/wnl.0000000000213377","journal":"Neurology","n_participants":null,"pmid":"40163795","source_url":"https://pubmed.ncbi.nlm.nih.gov/40163795/","study_design":"cross-sectional","title":"Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/a-novel-presenilin-1-mutation-ala275val-as-cause-of-early-onset-24582897","doi":"10.1016/j.neulet.2014.02.034","journal":"Neuroscience letters","n_participants":null,"pmid":"24582897","source_url":"https://pubmed.ncbi.nlm.nih.gov/24582897/","study_design":null,"title":"A novel presenilin 1 mutation (Ala275Val) as cause of early-onset familial Alzheimer disease","title_match":true,"year":2014},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/association-of-years-to-parent-s-sporadic-onset-and-risk-factors-with-32737076","doi":"10.1212/wnl.0000000000010527","journal":"Neurology","n_participants":290,"pmid":"32737076","source_url":"https://pubmed.ncbi.nlm.nih.gov/32737076/","study_design":null,"title":"Association of years to parent's sporadic onset and risk factors with neural integrity and Alzheimer biomarkers","title_match":false,"year":2020},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/sample-size-estimates-for-biomarker-based-outcome-measures-in-40118731","doi":"10.1016/j.tjpad.2025.100133","journal":"The journal of prevention of Alzheimer's disease","n_participants":200,"pmid":"40118731","source_url":"https://pubmed.ncbi.nlm.nih.gov/40118731/","study_design":null,"title":"Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/identification-of-genetic-modifiers-of-autosomal-dominant-alzheimer-s-42127933","doi":"10.1016/s1474-4422(26)00123-7","journal":"The Lancet. Neurology","n_participants":2338,"pmid":"42127933","source_url":"https://pubmed.ncbi.nlm.nih.gov/42127933/","study_design":null,"title":"Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study","title_match":true,"year":2026},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/association-of-resilience-related-life-experiences-on-variability-on-39270149","doi":"10.1212/wnl.0000000000209766","journal":"Neurology","n_participants":103,"pmid":"39270149","source_url":"https://pubmed.ncbi.nlm.nih.gov/39270149/","study_design":"longitudinal study","title":"Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease","title_match":true,"year":2024},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/multi-tissue-proteomics-identifies-molecular-signatures-for-sporadic-91194d89","doi":"10.21203/rs.3.rs-923492/v1","journal":"Research Square","n_participants":360,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-923492/v1","study_design":null,"title":"Multi-tissue proteomics identifies molecular signatures for sporadic and genetically defined Alzheimer disease cases","title_match":false,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/lecanemab-in-symptomatic-psen1-p-met233val-early-onset-alzheimer-s-42676462","doi":"10.1002/dad2.70468","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"42676462","source_url":"https://pubmed.ncbi.nlm.nih.gov/42676462/","study_design":"longitudinal study","title":"Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/abnormalities-in-core-ad-biomarkers-precede-inflammatory-and-glial-2a0fe361","doi":"10.64898/2026.03.31.26349851","journal":"medRxiv","n_participants":484,"pmid":null,"source_url":"https://doi.org/10.64898/2026.03.31.26349851","study_design":null,"title":"Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer\u2019s Disease","title_match":true,"year":2026},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/chmp2b-p-ala30ser-variant-in-biomarker-confirmed-early-onset-42246690","doi":"10.1097/wad.0000000000000737","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"42246690","source_url":"https://pubmed.ncbi.nlm.nih.gov/42246690/","study_design":null,"title":"CHMP2B p.Ala30Ser Variant in Biomarker-Confirmed Early-Onset Alzheimer Disease: A Potential Endolysosomal Disease Modifier","title_match":false,"year":2026},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/phenotypic-variability-in-early-onset-dementia-segregating-with-a-41327373","doi":"10.1186/s13195-025-01890-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"41327373","source_url":"https://pubmed.ncbi.nlm.nih.gov/41327373/","study_design":null,"title":"Phenotypic variability in early-onset dementia segregating with a novel APP (p.I718M) variant","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-and-its-treatment-yesterday-today-and-tomorrow-38868666","doi":"10.3389/fphar.2024.1399121","journal":"Frontiers in pharmacology","n_participants":null,"pmid":"38868666","source_url":"https://pubmed.ncbi.nlm.nih.gov/38868666/","study_design":"narrative review","title":"Alzheimer's disease and its treatment-yesterday, today, and tomorrow","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/conference-report-dementia-research-and-care-and-its-impact-in-33277912","doi":"10.4414/smw.2020.20376","journal":"Swiss medical weekly","n_participants":null,"pmid":"33277912","source_url":"https://pubmed.ncbi.nlm.nih.gov/33277912/","study_design":"longitudinal study","title":"Conference report: dementia research and care and its impact in Switzerland","title_match":false,"year":2020},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/education-and-alzheimer-disease-genetic-risk-in-associations-of-glp-1-dbbc063a","doi":"10.64898/2026.09.04.26362304","journal":"medRxiv","n_participants":14364,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.04.26362304","study_design":"cohort study","title":"Education and Alzheimer Disease Genetic Risk in Associations of GLP-1 Receptor Agonists With Dementia Among Adults With Type 2 Diabetes","title_match":true,"year":2026},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/donepezil-in-patients-with-subcortical-vascular-cognitive-impairment-18296124","doi":"10.1016/s1474-4422(08)70046-2","journal":"The Lancet. Neurology","n_participants":86,"pmid":"18296124","source_url":"https://pubmed.ncbi.nlm.nih.gov/18296124/","study_design":null,"title":"Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL","title_match":false,"year":2008},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/ambroxol-as-a-novel-disease-modifying-treatment-for-parkinson-s-30738426","doi":"10.1186/s12883-019-1252-3","journal":"BMC neurology","n_participants":75,"pmid":"30738426","source_url":"https://pubmed.ncbi.nlm.nih.gov/30738426/","study_design":null,"title":"Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial","title_match":false,"year":2019},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/the-effect-of-apoe-and-other-common-genetic-variants-on-the-onset-of-29555425","doi":"10.1016/s1474-4422(18)30053-x","journal":"The Lancet. Neurology","n_participants":926,"pmid":"29555425","source_url":"https://pubmed.ncbi.nlm.nih.gov/29555425/","study_design":"cohort study","title":"The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/genetic-variation-in-white-matter-hyperintensity-volume-in-the-15143299","doi":"10.1161/01.str.0000129643.77045.10","journal":"Stroke","n_participants":2012,"pmid":"15143299","source_url":"https://pubmed.ncbi.nlm.nih.gov/15143299/","study_design":null,"title":"Genetic variation in white matter hyperintensity volume in the Framingham Study","title_match":false,"year":2004},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/utility-of-the-global-cdr-sup-sup-plus-nacc-ftld-rating-and-31914218","doi":"10.1002/alz.12033","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":40,"pmid":"31914218","source_url":"https://pubmed.ncbi.nlm.nih.gov/31914218/","study_design":"longitudinal study","title":"Utility of the global CDR\u00ae plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium","title_match":false,"year":2020},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/cardiometabolic-multimorbidity-genetic-risk-and-dementia-a-35711612","doi":"10.1016/s2666-7568(22)00117-9","journal":"The lancet. Healthy longevity","n_participants":236,"pmid":"35711612","source_url":"https://pubmed.ncbi.nlm.nih.gov/35711612/","study_design":null,"title":"Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study","title_match":true,"year":2022},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genome-wide-interaction-analysis-of-pathological-hallmarks-in-32450446","doi":"10.1016/j.neurobiolaging.2020.04.025","journal":"Neurobiology of aging","n_participants":null,"pmid":"32450446","source_url":"https://pubmed.ncbi.nlm.nih.gov/32450446/","study_design":null,"title":"Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-for-prediction-of-disease-progression-in-33827960","doi":"10.1212/wnl.0000000000011848","journal":"Neurology","n_participants":277,"pmid":"33827960","source_url":"https://pubmed.ncbi.nlm.nih.gov/33827960/","study_design":"longitudinal study","title":"Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration","title_match":true,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-determinants-prediction-and-gene-environment-32934108","doi":"10.1136/jnnp-2020-323646","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":1276,"pmid":"32934108","source_url":"https://pubmed.ncbi.nlm.nih.gov/32934108/","study_design":null,"title":"Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank","title_match":false,"year":2020},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/physical-frailty-genetic-predisposition-and-incident-parkinson-disease-36912851","doi":"10.1001/jamaneurol.2023.0183","journal":"JAMA neurology","n_participants":101,"pmid":"36912851","source_url":"https://pubmed.ncbi.nlm.nih.gov/36912851/","study_design":"cohort study","title":"Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease","title_match":false,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/association-of-multimorbidity-disease-clusters-and-modification-by-36125811","doi":"10.1001/jamanetworkopen.2022.32124","journal":"JAMA network open","n_participants":960,"pmid":"36125811","source_url":"https://pubmed.ncbi.nlm.nih.gov/36125811/","study_design":"cohort study","title":"Association of Multimorbidity, Disease Clusters, and Modification by Genetic Factors With Risk of Dementia","title_match":false,"year":2022},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/use-of-the-cdr-plus-nacc-ftld-in-mild-ftld-data-from-the-artfl-31477517","doi":"10.1016/j.jalz.2019.05.013","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31477517","source_url":"https://pubmed.ncbi.nlm.nih.gov/31477517/","study_design":"longitudinal study","title":"Use of the CDR\u00ae plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium","title_match":false,"year":2020},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/high-blood-pressure-and-risk-of-dementia-a-two-sample-mendelian-33766239","doi":"10.1016/j.biopsych.2020.12.015","journal":"Biological psychiatry","n_participants":299024,"pmid":"33766239","source_url":"https://pubmed.ncbi.nlm.nih.gov/33766239/","study_design":"meta-analysis","title":"High Blood Pressure and Risk of Dementia: A Two-Sample Mendelian Randomization Study in the UK Biobank","title_match":false,"year":2021},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/genetic-risk-of-neurodegenerative-diseases-is-associated-with-mild-25916564","doi":"10.1016/j.jalz.2014.12.008","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"25916564","source_url":"https://pubmed.ncbi.nlm.nih.gov/25916564/","study_design":null,"title":"Genetic risk of neurodegenerative diseases is associated with mild cognitive impairment and conversion to dementia","title_match":true,"year":2015},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/genome-wide-meta-analysis-of-homocysteine-and-methionine-metabolism-24651765","doi":"10.1371/journal.pgen.1004214","journal":"PLoS genetics","n_participants":2710,"pmid":"24651765","source_url":"https://pubmed.ncbi.nlm.nih.gov/24651765/","study_design":"meta-analysis","title":"Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke","title_match":false,"year":2014},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/lt-i-gt-notch3-lt-i-gt-variants-are-more-common-than-expected-in-the-33712516","doi":"10.1136/jnnp-2020-325838","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":200,"pmid":"33712516","source_url":"https://pubmed.ncbi.nlm.nih.gov/33712516/","study_design":null,"title":"NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-genetic-risk-factor-apoe-e4-and-cognitive-abilities-27103599","doi":"10.1093/ageing/afw068","journal":"Age and ageing","n_participants":111739,"pmid":"27103599","source_url":"https://pubmed.ncbi.nlm.nih.gov/27103599/","study_design":null,"title":"Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants","title_match":true,"year":2016},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/maternal-family-history-is-associated-with-alzheimer-s-disease-22669011","doi":"10.3233/jad-2012-120676","journal":"Journal of Alzheimer's disease : JAD","n_participants":99,"pmid":"22669011","source_url":"https://pubmed.ncbi.nlm.nih.gov/22669011/","study_design":"cross-sectional","title":"Maternal family history is associated with Alzheimer's disease biomarkers","title_match":true,"year":2012},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/cardiovascular-health-genetic-risk-and-risk-of-dementia-in-the-32690788","doi":"10.1212/wnl.0000000000010306","journal":"Neurology","n_participants":null,"pmid":"32690788","source_url":"https://pubmed.ncbi.nlm.nih.gov/32690788/","study_design":null,"title":"Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study","title_match":true,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/association-of-social-isolation-loneliness-and-genetic-risk-with-35197341","doi":"10.1136/bmjopen-2021-053936","journal":"BMJ open","n_participants":70,"pmid":"35197341","source_url":"https://pubmed.ncbi.nlm.nih.gov/35197341/","study_design":null,"title":"Association of social isolation, loneliness and genetic risk with incidence of dementia: UK Biobank Cohort Study","title_match":true,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/association-between-polygenic-risk-score-of-alzheimer-s-disease-and-33419453","doi":"10.1186/s13195-020-00754-8","journal":"Alzheimer's research & therapy","n_participants":818,"pmid":"33419453","source_url":"https://pubmed.ncbi.nlm.nih.gov/33419453/","study_design":null,"title":"Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging Initiative","title_match":true,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/genetic-risk-of-alzheimer-s-disease-and-sleep-duration-in-non-32951248","doi":"10.1002/ana.25910","journal":"Annals of neurology","n_participants":null,"pmid":"32951248","source_url":"https://pubmed.ncbi.nlm.nih.gov/32951248/","study_design":null,"title":"Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Elders","title_match":true,"year":2021},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/rates-of-brain-atrophy-across-disease-stages-in-familial-33112398","doi":"10.1001/jamanetworkopen.2020.22847","journal":"JAMA network open","n_participants":100,"pmid":"33112398","source_url":"https://pubmed.ncbi.nlm.nih.gov/33112398/","study_design":"case-control study","title":"Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants","title_match":true,"year":2020},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/parental-family-history-of-dementia-in-relation-to-subclinical-brain-28356461","doi":"10.1212/wnl.0000000000003871","journal":"Neurology","n_participants":2087,"pmid":"28356461","source_url":"https://pubmed.ncbi.nlm.nih.gov/28356461/","study_design":null,"title":"Parental family history of dementia in relation to subclinical brain disease and dementia risk","title_match":true,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/familial-aggregation-of-parkinsonism-in-progressive-supranuclear-palsy-19458322","doi":"10.1212/wnl.0b013e3181a92bcc","journal":"Neurology","n_participants":172,"pmid":"19458322","source_url":"https://pubmed.ncbi.nlm.nih.gov/19458322/","study_design":"case-control study","title":"Familial aggregation of parkinsonism in progressive supranuclear palsy","title_match":true,"year":2009},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/assessment-of-executive-function-declines-in-presymptomatic-and-31914230","doi":"10.1016/j.jalz.2019.01.012","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":31,"pmid":"31914230","source_url":"https://pubmed.ncbi.nlm.nih.gov/31914230/","study_design":null,"title":"Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint","title_match":true,"year":2020},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/combining-polygenic-hazard-score-with-volumetric-mri-and-cognitive-29760643","doi":"10.3389/fnins.2018.00260","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"29760643","source_url":"https://pubmed.ncbi.nlm.nih.gov/29760643/","study_design":null,"title":"Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease","title_match":true,"year":2018},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/socioeconomic-deprivation-genetic-risk-and-incident-dementia-37085245","doi":"10.1016/j.amepre.2023.01.012","journal":"American journal of preventive medicine","n_participants":196368,"pmid":"37085245","source_url":"https://pubmed.ncbi.nlm.nih.gov/37085245/","study_design":"cohort study","title":"Socioeconomic Deprivation, Genetic Risk, and Incident Dementia","title_match":true,"year":2023},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-locus-duplication-as-a-cause-of-familial-parkinson-s-15451224","doi":"10.1016/s0140-6736(04)17103-1","journal":"Lancet (London, England)","n_participants":null,"pmid":"15451224","source_url":"https://pubmed.ncbi.nlm.nih.gov/15451224/","study_design":null,"title":"Alpha-synuclein locus duplication as a cause of familial Parkinson's disease","title_match":true,"year":2004},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/a-genome-wide-association-study-with-1-126-563-individuals-identifies-34493870","doi":"10.1038/s41588-021-00921-z","journal":"Nature genetics","n_participants":null,"pmid":"34493870","source_url":"https://pubmed.ncbi.nlm.nih.gov/34493870/","study_design":"meta-analysis","title":"A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/app-locus-duplication-causes-autosomal-dominant-early-onset-alzheimer-16369530","doi":"10.1038/ng1718","journal":"Nature genetics","n_participants":null,"pmid":"16369530","source_url":"https://pubmed.ncbi.nlm.nih.gov/16369530/","study_design":null,"title":"APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy","title_match":true,"year":2006},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/pathological-tdp-43-distinguishes-sporadic-amyotrophic-lateral-17469116","doi":"10.1002/ana.21147","journal":"Annals of neurology","n_participants":111,"pmid":"17469116","source_url":"https://pubmed.ncbi.nlm.nih.gov/17469116/","study_design":null,"title":"Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations","title_match":false,"year":2007},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/functional-brain-abnormalities-in-young-adults-at-genetic-risk-for-14688411","doi":"10.1073/pnas.2635903100","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"14688411","source_url":"https://pubmed.ncbi.nlm.nih.gov/14688411/","study_design":null,"title":"Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia","title_match":true,"year":2004},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-mitochondrial-cascade-hypothesis-for-sporadic-alzheimer-s-disease-15193340","doi":"10.1016/j.mehy.2003.12.045","journal":"Medical hypotheses","n_participants":null,"pmid":"15193340","source_url":"https://pubmed.ncbi.nlm.nih.gov/15193340/","study_design":null,"title":"A \"mitochondrial cascade hypothesis\" for sporadic Alzheimer's disease","title_match":false,"year":2004},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/comparative-lipidomic-analysis-of-mouse-and-human-brain-with-22134919","doi":"10.1074/jbc.m111.274142","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"22134919","source_url":"https://pubmed.ncbi.nlm.nih.gov/22134919/","study_design":null,"title":"Comparative lipidomic analysis of mouse and human brain with Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/presenile-dementia-and-cerebral-haemorrhage-linked-to-a-mutation-at-1303239","doi":"10.1038/ng0692-218","journal":"Nature genetics","n_participants":null,"pmid":"1303239","source_url":"https://pubmed.ncbi.nlm.nih.gov/1303239/","study_design":null,"title":"Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene","title_match":false,"year":1992},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/linkage-studies-in-familial-alzheimer-disease-evidence-for-chromosome-2035524","doi":null,"journal":"American journal of human genetics","n_participants":null,"pmid":"2035524","source_url":"https://pubmed.ncbi.nlm.nih.gov/2035524/","study_design":null,"title":"Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage","title_match":true,"year":1991},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-as-homeostatic-responses-to-age-related-myelin-19775776","doi":"10.1016/j.neurobiolaging.2009.08.007","journal":"Neurobiology of aging","n_participants":null,"pmid":"19775776","source_url":"https://pubmed.ncbi.nlm.nih.gov/19775776/","study_design":null,"title":"Alzheimer's disease as homeostatic responses to age-related myelin breakdown","title_match":false,"year":2011},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/mutant-genes-in-familial-alzheimer-s-disease-and-transgenic-models-9530504","doi":"10.1146/annurev.neuro.21.1.479","journal":"Annual review of neuroscience","n_participants":null,"pmid":"9530504","source_url":"https://pubmed.ncbi.nlm.nih.gov/9530504/","study_design":null,"title":"Mutant genes in familial Alzheimer's disease and transgenic models","title_match":true,"year":1998},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/novel-amyloid-precursor-protein-mutation-in-an-iowa-family-with-11409420","doi":"10.1002/ana.1009","journal":"Annals of neurology","n_participants":null,"pmid":"11409420","source_url":"https://pubmed.ncbi.nlm.nih.gov/11409420/","study_design":null,"title":"Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy","title_match":true,"year":2001},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/a-stop-codon-mutation-in-the-bri-gene-associated-with-familial-10391242","doi":"10.1038/21637","journal":"Nature","n_participants":null,"pmid":"10391242","source_url":"https://pubmed.ncbi.nlm.nih.gov/10391242/","study_design":null,"title":"A stop-codon mutation in the BRI gene associated with familial British dementia","title_match":true,"year":1999},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/nonapoptotic-neurodegeneration-in-a-transgenic-mouse-model-of-10869421","doi":"10.1073/pnas.110078997","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10869421","source_url":"https://pubmed.ncbi.nlm.nih.gov/10869421/","study_design":null,"title":"Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease","title_match":false,"year":2000},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/a-neurodevelopmental-approach-to-the-classification-of-schizophrenia-1377834","doi":"10.1093/schbul/18.2.319","journal":"Schizophrenia bulletin","n_participants":null,"pmid":"1377834","source_url":"https://pubmed.ncbi.nlm.nih.gov/1377834/","study_design":null,"title":"A neurodevelopmental approach to the classification of schizophrenia","title_match":false,"year":1992},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/phenotypic-variation-in-a-large-swedish-pedigree-due-to-snca-17251522","doi":"10.1212/01.wnl.0000254458.17630.c5","journal":"Neurology","n_participants":null,"pmid":"17251522","source_url":"https://pubmed.ncbi.nlm.nih.gov/17251522/","study_design":null,"title":"Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication","title_match":false,"year":2007},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-allele-in-a-population-based-study-of-early-onset-8075646","doi":"10.1038/ng0594-74","journal":"Nature genetics","n_participants":null,"pmid":"8075646","source_url":"https://pubmed.ncbi.nlm.nih.gov/8075646/","study_design":null,"title":"Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease","title_match":false,"year":1994},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/heritability-for-alzheimer-s-disease-the-study-of-dementia-in-swedish-9060980","doi":"10.1093/gerona/52a.2.m117","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":null,"pmid":"9060980","source_url":"https://pubmed.ncbi.nlm.nih.gov/9060980/","study_design":null,"title":"Heritability for Alzheimer's disease: the study of dementia in Swedish twins","title_match":true,"year":1997},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/understanding-the-role-of-tdp-43-and-fus-tls-in-als-and-beyond-21813273","doi":"10.1016/j.conb.2011.05.029","journal":"Current opinion in neurobiology","n_participants":null,"pmid":"21813273","source_url":"https://pubmed.ncbi.nlm.nih.gov/21813273/","study_design":null,"title":"Understanding the role of TDP-43 and FUS/TLS in ALS and beyond","title_match":false,"year":2011},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/hypothesis-microtubule-instability-and-paired-helical-filament-8313935","doi":"10.1006/exnr.1994.1019","journal":"Experimental neurology","n_participants":null,"pmid":"8313935","source_url":"https://pubmed.ncbi.nlm.nih.gov/8313935/","study_design":null,"title":"Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype","title_match":false,"year":1994},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-linkage-studies-suggest-that-alzheimer-s-disease-is-not-a-2395471","doi":"10.1038/347194a0","journal":"Nature","n_participants":null,"pmid":"2395471","source_url":"https://pubmed.ncbi.nlm.nih.gov/2395471/","study_design":null,"title":"Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder","title_match":false,"year":1990},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/clinico-pathological-features-in-amyotrophic-lateral-sclerosis-with-22366792","doi":"10.1093/brain/awr365","journal":"Brain : a journal of neurology","n_participants":361,"pmid":"22366792","source_url":"https://pubmed.ncbi.nlm.nih.gov/22366792/","study_design":null,"title":"Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72","title_match":false,"year":2012},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/tdp-43-in-the-ubiquitin-pathology-of-frontotemporal-dementia-with-vcp-17279000","doi":"10.1097/nen.0b013e31803020b9","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"17279000","source_url":"https://pubmed.ncbi.nlm.nih.gov/17279000/","study_design":null,"title":"TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations","title_match":false,"year":2007},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/rare-variants-in-app-psen1-and-psen2-increase-risk-for-ad-in-late-22312439","doi":"10.1371/journal.pone.0031039","journal":"PloS one","n_participants":null,"pmid":"22312439","source_url":"https://pubmed.ncbi.nlm.nih.gov/22312439/","study_design":null,"title":"Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families","title_match":true,"year":2012},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/neuronal-clearance-of-amyloid-by-endocytic-receptor-lrp1-24305823","doi":"10.1523/jneurosci.3487-13.2013","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"24305823","source_url":"https://pubmed.ncbi.nlm.nih.gov/24305823/","study_design":null,"title":"Neuronal clearance of amyloid-\u03b2 by endocytic receptor LRP1","title_match":false,"year":2013},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/mosaic-loss-of-chromosome-y-in-blood-is-associated-with-alzheimer-27231129","doi":"10.1016/j.ajhg.2016.05.014","journal":"American journal of human genetics","n_participants":null,"pmid":"27231129","source_url":"https://pubmed.ncbi.nlm.nih.gov/27231129/","study_design":"case-control study","title":"Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease","title_match":false,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/a-decamer-duplication-in-the-3-region-of-the-bri-gene-originates-an-10781099","doi":"10.1073/pnas.080076097","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10781099","source_url":"https://pubmed.ncbi.nlm.nih.gov/10781099/","study_design":null,"title":"A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred","title_match":false,"year":2000},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-clinical-features-and-classification-of-the-late-onset-autosomal-7066668","doi":"10.1093/brain/105.1.1","journal":"Brain : a journal of neurology","n_participants":73,"pmid":"7066668","source_url":"https://pubmed.ncbi.nlm.nih.gov/7066668/","study_design":null,"title":"The clinical features and classification of the late onset autosomal dominant cerebellar ataxias. A study of 11 families, including descendants of the 'the Drew family of Walworth'","title_match":true,"year":1982},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/tardbp-and-fus-mutations-associated-with-amyotrophic-lateral-23559573","doi":"10.1002/humu.22319","journal":"Human mutation","n_participants":null,"pmid":"23559573","source_url":"https://pubmed.ncbi.nlm.nih.gov/23559573/","study_design":null,"title":"TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update","title_match":false,"year":2013},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/time-to-diagnosis-in-young-onset-dementia-as-compared-with-late-onset-22640548","doi":"10.1017/s0033291712001122","journal":"Psychological medicine","n_participants":null,"pmid":"22640548","source_url":"https://pubmed.ncbi.nlm.nih.gov/22640548/","study_design":"cohort study","title":"Time to diagnosis in young-onset dementia as compared with late-onset dementia","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/tdp-43-mediates-degeneration-in-a-novel-drosophila-model-of-disease-20519548","doi":"10.1523/jneurosci.5894-09.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"20519548","source_url":"https://pubmed.ncbi.nlm.nih.gov/20519548/","study_design":null,"title":"TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/colocalization-of-transactivation-responsive-dna-binding-protein-43-19018245","doi":"10.1097/nen.0b013e31818e8951","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"19018245","source_url":"https://pubmed.ncbi.nlm.nih.gov/19018245/","study_design":null,"title":"Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease","title_match":false,"year":2008},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/autosomal-recessive-causes-likely-in-early-onset-alzheimer-disease-21911656","doi":"10.1001/archneurol.2011.221","journal":"Archives of neurology","n_participants":5370,"pmid":"21911656","source_url":"https://pubmed.ncbi.nlm.nih.gov/21911656/","study_design":null,"title":"Autosomal recessive causes likely in early-onset Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/genome-wide-association-of-familial-late-onset-alzheimer-s-disease-21379329","doi":"10.1371/journal.pgen.1001308","journal":"PLoS genetics","n_participants":null,"pmid":"21379329","source_url":"https://pubmed.ncbi.nlm.nih.gov/21379329/","study_design":null,"title":"Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE","title_match":true,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/experimental-models-of-vascular-dementia-and-vascular-cognitive-20731763","doi":"10.1111/j.1471-4159.2010.06958.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"20731763","source_url":"https://pubmed.ncbi.nlm.nih.gov/20731763/","study_design":null,"title":"Experimental models of vascular dementia and vascular cognitive impairment: a systematic review","title_match":false,"year":2010},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/genetic-association-of-the-low-density-lipoprotein-receptor-related-9222170","doi":"10.1212/wnl.49.1.56","journal":"Neurology","n_participants":null,"pmid":"9222170","source_url":"https://pubmed.ncbi.nlm.nih.gov/9222170/","study_design":null,"title":"Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease","title_match":false,"year":1997},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/phenotype-associated-with-app-duplication-in-five-families-16959815","doi":"10.1093/brain/awl237","journal":"Brain : a journal of neurology","n_participants":21,"pmid":"16959815","source_url":"https://pubmed.ncbi.nlm.nih.gov/16959815/","study_design":null,"title":"Phenotype associated with APP duplication in five families","title_match":false,"year":2006},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/gangliosides-and-gangliosidoses-principles-of-molecular-and-metabolic-23785136","doi":"10.1523/jneurosci.0822-13.2013","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"23785136","source_url":"https://pubmed.ncbi.nlm.nih.gov/23785136/","study_design":null,"title":"Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis","title_match":false,"year":2013},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genetics-and-molecular-pathogenesis-of-sporadic-and-hereditary-19225789","doi":"10.1007/s00401-009-0501-8","journal":"Acta neuropathologica","n_participants":null,"pmid":"19225789","source_url":"https://pubmed.ncbi.nlm.nih.gov/19225789/","study_design":null,"title":"Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies","title_match":false,"year":2009},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/diffusion-tensor-imaging-in-preclinical-and-presymptomatic-carriers-17522104","doi":"10.1093/brain/awm102","journal":"Brain : a journal of neurology","n_participants":20,"pmid":"17522104","source_url":"https://pubmed.ncbi.nlm.nih.gov/17522104/","study_design":"cross-sectional","title":"Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations","title_match":true,"year":2007},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/mutations-in-dnmt1-cause-autosomal-dominant-cerebellar-ataxia-22328086","doi":"10.1093/hmg/dds035","journal":"Human molecular genetics","n_participants":null,"pmid":"22328086","source_url":"https://pubmed.ncbi.nlm.nih.gov/22328086/","study_design":null,"title":"Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy","title_match":true,"year":2012},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/activation-of-beta2-adrenergic-receptor-stimulates-gamma-secretase-17115048","doi":"10.1038/nm1485","journal":"Nature medicine","n_participants":null,"pmid":"17115048","source_url":"https://pubmed.ncbi.nlm.nih.gov/17115048/","study_design":null,"title":"Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation","title_match":false,"year":2006},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/fus-mutations-in-amyotrophic-lateral-sclerosis-clinical-pathological-19965854","doi":"10.1136/jnnp.2009.194399","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"19965854","source_url":"https://pubmed.ncbi.nlm.nih.gov/19965854/","study_design":null,"title":"FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-phenotypes-and-genotypes-associated-with-20375137","doi":"10.1093/brain/awq033","journal":"Brain : a journal of neurology","n_participants":64,"pmid":"20375137","source_url":"https://pubmed.ncbi.nlm.nih.gov/20375137/","study_design":null,"title":"Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2","title_match":true,"year":2010},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/vcp-disease-associated-with-myopathy-paget-disease-of-bone-and-18845250","doi":"10.1016/j.bbadis.2008.09.003","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"18845250","source_url":"https://pubmed.ncbi.nlm.nih.gov/18845250/","study_design":null,"title":"VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder","title_match":false,"year":2008},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/mutations-in-chmp2b-in-lower-motor-neuron-predominant-amyotrophic-20352044","doi":"10.1371/journal.pone.0009872","journal":"PloS one","n_participants":null,"pmid":"20352044","source_url":"https://pubmed.ncbi.nlm.nih.gov/20352044/","study_design":null,"title":"Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)","title_match":false,"year":2010},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/causative-and-susceptibility-genes-for-alzheimer-s-disease-a-review-12788204","doi":"10.1016/s0361-9230(03)00067-4","journal":"Brain research bulletin","n_participants":null,"pmid":"12788204","source_url":"https://pubmed.ncbi.nlm.nih.gov/12788204/","study_design":null,"title":"Causative and susceptibility genes for Alzheimer's disease: a review","title_match":false,"year":2003},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/synuclein-toxicity-in-neurodegeneration-mechanism-and-therapeutic-28170377","doi":"10.1038/nm.4269","journal":"Nature medicine","n_participants":null,"pmid":"28170377","source_url":"https://pubmed.ncbi.nlm.nih.gov/28170377/","study_design":null,"title":"\u03b1-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies","title_match":false,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/neurobiology-of-ammonia-12207972","doi":"10.1016/s0301-0082(02)00019-9","journal":"Progress in neurobiology","n_participants":null,"pmid":"12207972","source_url":"https://pubmed.ncbi.nlm.nih.gov/12207972/","study_design":null,"title":"Neurobiology of ammonia","title_match":false,"year":2002},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/the-complex-genetic-architecture-of-alzheimer-s-disease-novel-36907103","doi":"10.1016/j.ebiom.2023.104511","journal":"EBioMedicine","n_participants":null,"pmid":"36907103","source_url":"https://pubmed.ncbi.nlm.nih.gov/36907103/","study_design":null,"title":"The complex genetic architecture of Alzheimer's disease: novel insights and future directions","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/rage-yin-versus-lrp-yang-balance-regulates-alzheimer-amyloid-beta-15459432","doi":"10.1161/01.str.0000143452.85382.d1","journal":"Stroke","n_participants":null,"pmid":"15459432","source_url":"https://pubmed.ncbi.nlm.nih.gov/15459432/","study_design":null,"title":"RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier","title_match":false,"year":2004},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/progranulin-deficiency-promotes-neuroinflammation-and-neuron-loss-23041626","doi":"10.1172/jci63113","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"23041626","source_url":"https://pubmed.ncbi.nlm.nih.gov/23041626/","study_design":null,"title":"Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury","title_match":false,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/microglial-activation-and-beta-amyloid-deposit-reduction-caused-by-a-11896164","doi":"10.1523/jneurosci.22-06-02246.2002","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"11896164","source_url":"https://pubmed.ncbi.nlm.nih.gov/11896164/","study_design":null,"title":"Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice","title_match":true,"year":2002},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/microglial-immunophenotype-in-dementia-with-alzheimer-s-pathology-27256292","doi":"10.1186/s12974-016-0601-z","journal":"Journal of neuroinflammation","n_participants":299,"pmid":"27256292","source_url":"https://pubmed.ncbi.nlm.nih.gov/27256292/","study_design":null,"title":"Microglial immunophenotype in dementia with Alzheimer's pathology","title_match":false,"year":2016},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/cerebral-microvascular-amyloid-beta-protein-deposition-induces-16049335","doi":"10.1016/s0002-9440(10)62993-8","journal":"The American journal of pathology","n_participants":null,"pmid":"16049335","source_url":"https://pubmed.ncbi.nlm.nih.gov/16049335/","study_design":null,"title":"Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein","title_match":false,"year":2005},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/actin-dynamics-and-cofilin-actin-rods-in-alzheimer-disease-26873625","doi":"10.1002/cm.21282","journal":"Cytoskeleton (Hoboken, N.J.)","n_participants":null,"pmid":"26873625","source_url":"https://pubmed.ncbi.nlm.nih.gov/26873625/","study_design":null,"title":"Actin dynamics and cofilin-actin rods in alzheimer disease","title_match":false,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/inhibition-of-p25-cdk5-attenuates-tauopathy-in-mouse-and-ipsc-models-28912154","doi":"10.1523/jneurosci.0621-17.2017","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"28912154","source_url":"https://pubmed.ncbi.nlm.nih.gov/28912154/","study_design":null,"title":"Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia","title_match":false,"year":2017},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-dementia-a-prevalent-disorder-with-specific-6200894","doi":"10.1017/s0033291700003081","journal":"Psychological Medicine","n_participants":null,"pmid":"6200894","source_url":"https://pubmed.ncbi.nlm.nih.gov/6200894/","study_design":null,"title":"Familial Alzheimer Dementia: a prevalent disorder with specific clinical features","title_match":true,"year":1984},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/a-health-ecological-model-study-of-subjective-cognitive-decline-among-42448799","doi":"10.1038/s41598-026-62335-3","journal":"Scientific Reports","n_participants":null,"pmid":"42448799","source_url":"https://pubmed.ncbi.nlm.nih.gov/42448799/","study_design":"cross-sectional","title":"A health ecological model study of subjective cognitive decline among hypertensive patients in rural Shanxi, China","title_match":false,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/deep-neural-networks-and-genome-wide-associations-reveal-the-41381974","doi":"10.1007/s11357-025-02046-1","journal":"GeroScience","n_participants":null,"pmid":"41381974","source_url":"https://pubmed.ncbi.nlm.nih.gov/41381974/","study_design":null,"title":"Deep neural networks and genome-wide associations reveal the polygenic architecture of local brain aging","title_match":true,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/psychosis-in-children-and-youth-focus-on-early-onset-schizophrenia-5e23a1b9","doi":"10.1542/pir.34.7.296","journal":"Pediatrics in Review","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1542/pir.34.7.296","study_design":null,"title":"Psychosis in Children and Youth: Focus on Early-Onset Schizophrenia","title_match":false,"year":2013},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/higher-neighborhood-deprivation-is-associated-with-accelerated-41346478","doi":"10.1002/bsa3.70045","journal":"Alzheimer s & Dementia Behavior & Socioeconomics of Aging","n_participants":161,"pmid":"41346478","source_url":"https://pubmed.ncbi.nlm.nih.gov/41346478/","study_design":"longitudinal study","title":"Higher neighborhood deprivation is associated with accelerated disease progression in behavioral\u2010variant frontotemporal degeneration","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/arealevel-deprivation-is-associated-with-rate-of-memory-decline-in-ccce1fef","doi":"10.1002/alz.056608","journal":"Alzheimer s & Dementia","n_participants":2554,"pmid":null,"source_url":"https://doi.org/10.1002/alz.056608","study_design":"longitudinal study","title":"Area\u2010level deprivation is associated with rate of memory decline in late life within a community\u2010based cohort","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/lecanemab-in-diad-6month-amyloid-pet-results-from-the-diantu001-trial-41447716","doi":"10.1002/alz70859_105303","journal":"Alzheimer s & Dementia","n_participants":97,"pmid":"41447716","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740335/","study_design":null,"title":"Lecanemab in DIAD: 6\u2010Month Amyloid PET Results from the DIAN\u2010TU\u2010001 Trial","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/immunohistochemical-evaluation-of-a-trial-of-gantenerumab-or-40459787","doi":"10.1007/s00401-025-02890-7","journal":"Acta Neuropathologica","n_participants":null,"pmid":"40459787","source_url":"https://pubmed.ncbi.nlm.nih.gov/40459787/","study_design":null,"title":"Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease","title_match":true,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-polygenic-risk-score-for-5-diseases-with-alzheimer-39836940","doi":"10.1212/wnl.0000000000210250","journal":"Neurology","n_participants":752,"pmid":"39836940","source_url":"https://pubmed.ncbi.nlm.nih.gov/39836940/","study_design":"prospective cohort","title":"Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-association-between-polygenic-risk-for-alzheimer-s-objective-4ef9e396","doi":"10.61919/wyfc0r72","journal":"Journal of Health Wellness and Community Research","n_participants":84,"pmid":null,"source_url":"https://doi.org/10.61919/wyfc0r72","study_design":"cross-sectional","title":"The Association Between Polygenic Risk for Alzheimer's, Objective Sleep Architecture, and Plasma Neurofilament Light Chain in Midlife","title_match":true,"year":2026},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/genomewide-association-studies-of-tdp43-proteinopathy-and-hippocampal-41208712","doi":"10.1002/alz.70760","journal":"Alzheimer s & Dementia","n_participants":9509,"pmid":"41208712","source_url":"https://pubmed.ncbi.nlm.nih.gov/41208712/","study_design":"meta-analysis","title":"Genome\u2010wide association studies of TDP\u201043 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-spectrum-of-genetic-risk-in-alzheimer-disease-39885961","doi":"10.1212/nxg.0000000000200224","journal":"Neurology Genetics","n_participants":null,"pmid":"39885961","source_url":"https://pubmed.ncbi.nlm.nih.gov/39885961/","study_design":null,"title":"The Spectrum of Genetic Risk in Alzheimer Disease","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/single-cell-polygenic-risk-scores-dissect-cellular-and-molecular-40715455","doi":"10.1038/s41587-025-02725-6","journal":"Nature Biotechnology","n_participants":null,"pmid":"40715455","source_url":"https://pubmed.ncbi.nlm.nih.gov/40715455/","study_design":null,"title":"Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases","title_match":true,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-impact-of-polygenic-risk-for-alzheimers-disease-on-40851051","doi":"10.1007/s10072-025-08393-3","journal":"Neurological Sciences","n_participants":null,"pmid":"40851051","source_url":"https://pubmed.ncbi.nlm.nih.gov/40851051/","study_design":null,"title":"The impact of polygenic risk for alzheimer\u2019s disease on neurotransmitter-related grey matter atrophy in the alzheimer continuum","title_match":true,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/multi-omic-derived-cell-type-specific-alzheimer-disease-polygenic-40706314","doi":"10.1016/j.neurobiolaging.2025.07.009","journal":"Neurobiology of Aging","n_participants":null,"pmid":"40706314","source_url":"https://pubmed.ncbi.nlm.nih.gov/40706314/","study_design":null,"title":"Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores","title_match":true,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/higher-level-of-3h-ucb-j-binding-in-apoe-4-allele-carriers-with-39900278","doi":"10.1016/j.neulet.2025.138135","journal":"Neuroscience Letters","n_participants":null,"pmid":"39900278","source_url":"https://pubmed.ncbi.nlm.nih.gov/39900278/","study_design":null,"title":"Higher level of [3H]UCB-J binding in ApoE \u01904 allele carriers with Alzheimer disease","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/clinical-biological-and-functional-connectivity-profile-of-patients-41348997","doi":"10.1212/wnl.0000000000214449","journal":"Neurology","n_participants":null,"pmid":"41348997","source_url":"https://pubmed.ncbi.nlm.nih.gov/41348997/","study_design":null,"title":"Clinical, Biological, and Functional Connectivity Profile of Patients With De Novo Parkinson Disease Who Are APOE \u03b54 Carriers","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-4-and-accelerated-cognitive-decline-among-cognitively-healthy-41790466","doi":"10.1001/jamanetworkopen.2026.0853","journal":"JAMA Network Open","n_participants":4392,"pmid":"41790466","source_url":"https://pubmed.ncbi.nlm.nih.gov/41790466/","study_design":"cohort study","title":"APOE \u03b54 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-4-linked-effects-on-clinical-features-and-neuropathology-in-41074912","doi":"10.1002/alz.70795","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41074912","source_url":"https://pubmed.ncbi.nlm.nih.gov/41074912/","study_design":null,"title":"APOE \u03b54 linked effects on clinical features and neuropathology in dementia with Lewy bodies","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/tgf-pathwaybased-polygenic-risk-score-modifies-the-association-41920173","doi":"10.1158/1055-9965.epi-25-1754","journal":"Cancer Epidemiology Biomarkers & Prevention","n_participants":204,"pmid":"41920173","source_url":"https://pubmed.ncbi.nlm.nih.gov/41920173/","study_design":null,"title":"TGF-\u03b2 Pathway\u2013Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method","title_match":true,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/exploring-immediate-responses-to-apoe-4-4-genotype-and-alzheimer-s-41906765","doi":"10.1177/13872877261435633","journal":"Journal of Alzheimer s Disease","n_participants":61,"pmid":"41906765","source_url":"https://pubmed.ncbi.nlm.nih.gov/41906765/","study_design":null,"title":"Exploring immediate responses to APOE \u03b5 4/\u03b54 genotype and Alzheimer's disease risk disclosure in Latinos","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/genetic-analysis-of-retinal-cell-types-in-neuropsychiatric-disorders-39775833","doi":"10.1001/jamapsychiatry.2024.4230","journal":"JAMA Psychiatry","n_participants":36,"pmid":"39775833","source_url":"https://pubmed.ncbi.nlm.nih.gov/39775833/","study_design":"cohort study","title":"Genetic Analysis of Retinal Cell Types in Neuropsychiatric Disorders","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/combating-genetic-heterogeneity-for-polygenic-prediction-of-40703204","doi":"10.1212/nxg.0000000000200266","journal":"Neurology Genetics","n_participants":null,"pmid":"40703204","source_url":"https://pubmed.ncbi.nlm.nih.gov/40703204/","study_design":null,"title":"Combating Genetic Heterogeneity for Polygenic Prediction of Susceptibility to Brain \u03b2-Amyloid Deposition","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/predictive-value-of-the-alzheimer-polygenic-risk-score-on-cognitive-42594416","doi":"10.1016/j.tjpad.2026.100658","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":7233,"pmid":"42594416","source_url":"https://pubmed.ncbi.nlm.nih.gov/42594416/","study_design":"longitudinal study","title":"Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia","title_match":true,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/longitudinal-association-of-a-polygenic-risk-score-for-plasma-t-tau-41043097","doi":"10.1212/wnl.0000000000213904","journal":"Neurology","n_participants":142637,"pmid":"41043097","source_url":"https://pubmed.ncbi.nlm.nih.gov/41043097/","study_design":null,"title":"Longitudinal Association of a Polygenic Risk Score for Plasma T-Tau With Incident Alzheimer Dementia and Mild Cognitive Impairment","title_match":true,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/local-genetic-covariance-analysis-with-lipid-traits-identifies-novel-40096060","doi":"10.1371/journal.pgen.1011631","journal":"PLoS Genetics","n_participants":19668,"pmid":"40096060","source_url":"https://pubmed.ncbi.nlm.nih.gov/40096060/","study_design":"meta-analysis","title":"Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer\u2019s Disease","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/hormone-replacement-therapy-in-women-and-vascular-risk-factors-modify-41434242","doi":"10.1002/alz70861_108536","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41434242","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725738/","study_design":null,"title":"Hormone replacement therapy in women and vascular risk factors modify the association of a multi\u2010ancestry polygenic risk score with Alzheimer disease and related traits","title_match":true,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/effects-of-sexual-differentiation-and-apoe-genotype-on-the-93b65e21","doi":"10.1186/s13293-026-00967-w","journal":"Biology of Sex Differences","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1186/s13293-026-00967-w","study_design":null,"title":"Effects of sexual differentiation and APOE genotype on the development of Alzheimer-related pathology in female EFAD mice","title_match":false,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/estimated-glucose-disposal-rate-and-risk-of-stroke-and-dementia-in-40931834","doi":"10.1161/atvbaha.125.322702","journal":"Arteriosclerosis Thrombosis and Vascular Biology","n_participants":93,"pmid":"40931834","source_url":"https://pubmed.ncbi.nlm.nih.gov/40931834/","study_design":"cohort study","title":"Estimated Glucose Disposal Rate and Risk of Stroke and Dementia in Nondiabetics: A UK Biobank Prospective Cohort Study","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cell-weighted-polygenic-risk-scores-are-associated-with-amyloid-and-41040848","doi":"10.1093/braincomms/fcaf353","journal":"Brain Communications","n_participants":734,"pmid":"41040848","source_url":"https://pubmed.ncbi.nlm.nih.gov/41040848/","study_design":null,"title":"Cell-weighted polygenic risk scores are associated with \u03b2-amyloid and tau biomarkers in Alzheimer\u2019s disease","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/milestone-review-the-history-of-molecular-genetics-analysis-of-40600356","doi":"10.1111/jnc.70148","journal":"Journal of Neurochemistry","n_participants":null,"pmid":"40600356","source_url":"https://pubmed.ncbi.nlm.nih.gov/40600356/","study_design":null,"title":"Milestone Review: The History of Molecular Genetics Analysis of Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/evaluation-of-polygenic-risk-scores-for-a-possible-genetic-basis-of-41128446","doi":"10.1097/wad.0000000000000696","journal":"Alzheimer Disease & Associated Disorders","n_participants":null,"pmid":"41128446","source_url":"https://pubmed.ncbi.nlm.nih.gov/41128446/","study_design":null,"title":"Evaluation of Polygenic Risk Scores for a Possible Genetic Basis of the Inverse Association Between Cancer and Cognitive Decline","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/lysosomal-proteomics-reveals-mechanisms-of-neuronal-apoe4-associated-41103078","doi":"10.1080/15548627.2025.2576613","journal":"Autophagy","n_participants":null,"pmid":"41103078","source_url":"https://pubmed.ncbi.nlm.nih.gov/41103078/","study_design":null,"title":"Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/evaluation-of-the-relationships-between-inflammatory-markers-and-13971599","doi":"10.1192/j.eurpsy.2026.11269","journal":"European Psychiatry","n_participants":135,"pmid":null,"source_url":"https://doi.org/10.1192/j.eurpsy.2026.11269","study_design":null,"title":"Evaluation of the relationships between inflammatory markers and processing speed in recent-onset and chronic schizophrenia: a polygenic risk score study","title_match":true,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/dissecting-alzheimer-disease-heritability-across-multiple-populations-41436227","doi":"10.1002/alz70855_102132","journal":"Alzheimer s & Dementia","n_participants":7024,"pmid":"41436227","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12727212/","study_design":null,"title":"Dissecting Alzheimer Disease Heritability Across Multiple Populations","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/microgliaspecific-alzheimer-s-disease-polygenic-risk-score-predicts-41518606","doi":"10.1002/alz70856_106441","journal":"Alzheimer s & Dementia","n_participants":474,"pmid":"41518606","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12790387/","study_design":"longitudinal study","title":"Microglia\u2010specific Alzheimer's disease polygenic risk score predicts longitudinal increase in plasma tau and faster cognitive decline in cognitively unimpaired older adults","title_match":true,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/novel-drug-delivery-system-a-pandora-box-for-the-manage-ment-of-f13bd11e","doi":"10.4238/0fganh12","journal":"Genetics and Molecular Research","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.4238/0fganh12","study_design":null,"title":"NOVEL DRUG DELIVERY SYSTEM: A PANDORA BOX FOR THE MANAGE MENT OF ALZHEIMER NOVEL DRUG DELIVERY IN ALZHEIMER","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/influence-of-cardiometabolic-and-alzheimer-disease-genetics-on-42234953","doi":"10.1212/wnl.0000000000218163","journal":"Neurology","n_participants":null,"pmid":"42234953","source_url":"https://pubmed.ncbi.nlm.nih.gov/42234953/","study_design":null,"title":"Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population","title_match":false,"year":2026},{"alzhub_score":29,"alzhub_url":"https://alzhub.org/study/adam10-and-its-role-in-alzheimer-disease-42097504","doi":"10.1016/j.nrleng.2026.502083","journal":"Neurolog\u00eda (English Edition)","n_participants":null,"pmid":"42097504","source_url":"https://pubmed.ncbi.nlm.nih.gov/42097504/","study_design":null,"title":"ADAM10 and its role in Alzheimer disease","title_match":false,"year":2026},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/prediction-of-alzheimer-patients-with-machine-learning-algorithms-3ad6cbcf","doi":"10.33022/ijcs.v14i3.4364","journal":"Indonesian Journal of Computer Science","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.33022/ijcs.v14i3.4364","study_design":null,"title":"Prediction Of Alzheimer Patients with Machine Learning Algorithms","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/active-travel-mode-and-incident-dementia-and-brain-structure-40489111","doi":"10.1001/jamanetworkopen.2025.14316","journal":"JAMA Network Open","n_participants":723,"pmid":"40489111","source_url":"https://pubmed.ncbi.nlm.nih.gov/40489111/","study_design":"cohort study","title":"Active Travel Mode and Incident Dementia and Brain Structure","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/peruvian-population-empowers-discovery-of-a-trem2-missense-variant-in-41444117","doi":"10.1002/alz70855_105970","journal":"Alzheimer s & Dementia","n_participants":567,"pmid":"41444117","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12738110/","study_design":null,"title":"Peruvian Population Empowers Discovery of a TREM2 Missense Variant in Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/dissecting-the-genetic-and-proteomic-risk-factors-for-delirium-41286463","doi":"10.1038/s43587-025-01018-6","journal":"Nature Aging","n_participants":1059130,"pmid":"41286463","source_url":"https://pubmed.ncbi.nlm.nih.gov/41286463/","study_design":"meta-analysis","title":"Dissecting the genetic and proteomic risk factors for delirium","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-4-and-cognition-among-middle-aged-and-older-east-asian-adults-41790473","doi":"10.1001/jamanetworkopen.2026.0860","journal":"JAMA Network Open","n_participants":21,"pmid":"41790473","source_url":"https://pubmed.ncbi.nlm.nih.gov/41790473/","study_design":"longitudinal study","title":"APOE \u03b54 and Cognition Among Middle-Aged and Older East Asian Adults","title_match":false,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-fall-dementia-connection-synergistic-effects-of-falls-with-40325974","doi":"10.1177/13872877251333799","journal":"Journal of Alzheimer s Disease","n_participants":403502,"pmid":"40325974","source_url":"https://pubmed.ncbi.nlm.nih.gov/40325974/","study_design":null,"title":"The fall-dementia connection: Synergistic effects of falls with genetic and health risk factors","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/declining-to-learn-results-of-research-biomarker-tests-for-alzheimer-41448191","doi":"10.1002/alz70858_101067","journal":"Alzheimer s & Dementia","n_participants":274,"pmid":"41448191","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740484/","study_design":"longitudinal study","title":"Declining to learn results of research biomarker tests for Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/heterogeneity-in-the-genetic-architecture-of-alzheimer-disease-ad-41447272","doi":"10.1002/alz70855_107285","journal":"Alzheimer s & Dementia","n_participants":6343,"pmid":"41447272","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12739911/","study_design":null,"title":"Heterogeneity in the Genetic Architecture of Alzheimer disease (AD) across Ancestry Groups","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/identification-and-catalog-of-viral-transcriptional-regulators-in-40124487","doi":"10.1016/j.isci.2025.112081","journal":"iScience","n_participants":null,"pmid":"40124487","source_url":"https://pubmed.ncbi.nlm.nih.gov/40124487/","study_design":null,"title":"Identification and catalog of viral transcriptional regulators in human diseases","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/novel-earlyonset-alzheimerassociated-genes-influence-risk-through-41444475","doi":"10.1002/alz70855_107379","journal":"Alzheimer s & Dementia","n_participants":15,"pmid":"41444475","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12738202/","study_design":null,"title":"Novel early\u2010onset Alzheimer\u2010associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/assessing-the-de-novo-paradigm-in-sporadic-early-onset-alzheimer-42215639","doi":"10.1038/s41380-026-03665-6","journal":"Molecular Psychiatry","n_participants":null,"pmid":"42215639","source_url":"https://pubmed.ncbi.nlm.nih.gov/42215639/","study_design":null,"title":"Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios","title_match":false,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/o-impacto-da-genetica-e-fatores-epigeneticos-no-desenvolvimento-do-4f8b0b66","doi":"10.36557/2674-8169.2025v7n4p1163-1180","journal":"Brazilian Journal of Implantology and Health Sciences","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.36557/2674-8169.2025v7n4p1163-1180","study_design":null,"title":"O impacto da gen\u00e9tica e fatores epigen\u00e9ticos no desenvolvimento do Alzheimer","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/identification-of-genetic-modifiers-influencing-disease-risk-in-41442552","doi":"10.1002/alz70855_105550","journal":"Alzheimer s & Dementia","n_participants":91,"pmid":"41442552","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12735601/","study_design":null,"title":"Identification of genetic modifiers influencing disease risk in autosomal dominant Alzheimer disease mutation carriers","title_match":true,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/exploring-the-pathogenesis-of-alzheimer-disease-in-basal-forebrain-521df110","doi":"10.25258/ijddt.16.32s.128","journal":"International Journal of Drug Delivery Technology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.25258/ijddt.16.32s.128","study_design":null,"title":"Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons and Converging Insights from Alternative Hypothesis","title_match":false,"year":2026},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/elevated-csf-levels-of-matrix-metalloproteinase12-as-a-potential-41518635","doi":"10.1002/alz70856_107566","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41518635","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12790406/","study_design":null,"title":"Elevated CSF levels of matrix metalloproteinase\u201012 as a potential marker for microhemorrhage risk in autosomal dominant Alzheimer disease","title_match":true,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/elevated-csf-levels-of-matrix-metalloproteinase12-as-a-potential-41433535","doi":"10.1002/alz70862_109993","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41433535","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725258/","study_design":null,"title":"Elevated CSF levels of matrix metalloproteinase\u201012 as a potential marker for microhemorrhage risk in autosomal dominant Alzheimer disease","title_match":true,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/aplicaciones-de-la-genetica-clinica-en-el-diagnostico-y-pronostico-de-0e925d31","doi":"10.23857/pc.v10i12.10941","journal":"Polo del Conocimiento","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.23857/pc.v10i12.10941","study_design":null,"title":"Aplicaciones de la gen\u00e9tica cl\u00ednica en el diagn\u00f3stico y pron\u00f3stico de Alzheimer: una revisi\u00f3n actualizada","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-an-integrated-multidisciplinary-perspective-on-2448a12c","doi":"10.64483/202522763","journal":"Saudi Journal of Medicine and Public Health","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64483/202522763","study_design":"narrative review","title":"Alzheimer Disease: An Integrated Multidisciplinary Perspective on Pathophysiology, Diagnosis, Management, and Contemporary Therapeutic Advances for Pharmacists, Neurologists, Nurses, Health Information Professionals, and Healthcare Assistants","title_match":false,"year":2025},{"alzhub_score":29,"alzhub_url":"https://alzhub.org/study/predalz-an-ensemble-learning-framework-for-identifying-genetic-42163597","doi":"10.2174/0113894501408301251214192633","journal":"Current Drug Targets","n_participants":null,"pmid":"42163597","source_url":"https://pubmed.ncbi.nlm.nih.gov/42163597/","study_design":null,"title":"predALZ: An Ensemble Learning Framework for Identifying Genetic Biomarkers in Familial Alzheimer\u2019s Disease","title_match":true,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/the-joint-effects-of-lifes-essential-8-and-genetics-on-mild-cognitive-42658064","doi":"10.2337/dc25-3126","journal":"Diabetes Care","n_participants":41374,"pmid":"42658064","source_url":"https://pubmed.ncbi.nlm.nih.gov/42658064/","study_design":null,"title":"The Joint Effects of Life\u2019s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us","title_match":false,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/lecanemab-binds-to-transgenic-mouse-modelderived-amyloid-fibril-40495448","doi":"10.1111/nan.70022","journal":"Neuropathology and Applied Neurobiology","n_participants":null,"pmid":"40495448","source_url":"https://pubmed.ncbi.nlm.nih.gov/40495448/","study_design":null,"title":"Lecanemab Binds to Transgenic Mouse Model\u2010Derived Amyloid\u2010\u03b2 Fibril Structures Resembling Alzheimer's Disease Type I, Type II and Arctic Folds","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-neuroimaging-initiative-two-decades-of-pioneering-39760440","doi":"10.1002/alz.14186","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"39760440","source_url":"https://pubmed.ncbi.nlm.nih.gov/39760440/","study_design":"longitudinal study","title":"Alzheimer's Disease Neuroimaging Initiative: Two decades of pioneering Alzheimer's disease research and future directions","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/assessing-family-history-and-approaches-for-identifying-patients-with-40621734","doi":"10.1016/j.gim.2025.101517","journal":"Genetics in Medicine","n_participants":701,"pmid":"40621734","source_url":"https://pubmed.ncbi.nlm.nih.gov/40621734/","study_design":null,"title":"Assessing family history and approaches for identifying patients with dementia with diagnostically significant genetic findings","title_match":true,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/oral-microbiome-and-its-emerging-role-in-alzheimer-s-disease-a-ae0cd918","doi":"10.5005/jactem-11048-0030","journal":"Journal of Acute Care Trauma and Emergency Medicine","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5005/jactem-11048-0030","study_design":"longitudinal study","title":"Oral Microbiome and Its Emerging Role in Alzheimer\\'s Disease: A Comprehensive Review","title_match":false,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/redefining-alzheimers-disease-through-modern-biotechnology-from-92541794","doi":"10.65035/w1y9ey43","journal":"Journal of medical & health sciences review.","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.65035/w1y9ey43","study_design":null,"title":"REDEFINING ALZHEIMER\u2019S DISEASE THROUGH MODERN BIOTECHNOLOGY; FROM MOLECULAR PATHOGENESIS TO INNOVATIVE THERAPEUTICS AND DIAGNOSTIC FRONTIERS","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/baseline-imaging-characteristics-of-participants-in-the-phase-ii-iii-41447186","doi":"10.1002/alz70859_105301","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41447186","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12739784/","study_design":null,"title":"Baseline Imaging Characteristics of Participants in the Phase II/III DIAN\u2010TU\u2010001 Tau NexGen Trial for Dominantly Inherited Alzheimer\u2019s Disease","title_match":true,"year":2025},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/genetic-and-lifestyle-risks-for-coronary-artery-disease-and-long-term-40181791","doi":"10.1161/circulationaha.124.070632","journal":"Circulation","n_participants":782,"pmid":"40181791","source_url":"https://pubmed.ncbi.nlm.nih.gov/40181791/","study_design":"cohort study","title":"Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-exposome-and-pancreatic-cancer-lifestyle-and-environmental-risk-40368260","doi":"10.1016/j.semcancer.2025.05.004","journal":"Seminars in Cancer Biology","n_participants":null,"pmid":"40368260","source_url":"https://pubmed.ncbi.nlm.nih.gov/40368260/","study_design":null,"title":"The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/understanding-susceptibility-to-breast-cancer-from-risk-factors-to-40243654","doi":"10.3390/ijms26072993","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"40243654","source_url":"https://pubmed.ncbi.nlm.nih.gov/40243654/","study_design":null,"title":"Understanding Susceptibility to Breast Cancer: From Risk Factors to Prevention Strategies","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/how-do-lifestyle-and-environmental-factors-influence-the-sperm-39819375","doi":"10.1186/s13148-025-01815-1","journal":"Clinical Epigenetics","n_participants":null,"pmid":"39819375","source_url":"https://pubmed.ncbi.nlm.nih.gov/39819375/","study_design":null,"title":"How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/environment-lifestyle-and-cancer-in-women-40277318","doi":"10.1002/ijgo.70156","journal":"International Journal of Gynecology & Obstetrics","n_participants":null,"pmid":"40277318","source_url":"https://pubmed.ncbi.nlm.nih.gov/40277318/","study_design":null,"title":"Environment, lifestyle, and cancer in women","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/hereditary-breast-cancer-comprehensive-risk-assessment-and-prevention-39858629","doi":"10.3390/genes16010082","journal":"Genes","n_participants":null,"pmid":"39858629","source_url":"https://pubmed.ncbi.nlm.nih.gov/39858629/","study_design":null,"title":"Hereditary Breast Cancer: Comprehensive Risk Assessment and Prevention Strategies","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/exercise-prescription-in-arrhythmogenic-cardiomyopathy-finding-the-40470644","doi":"10.1161/jaha.124.039125","journal":"Journal of the American Heart Association","n_participants":null,"pmid":"40470644","source_url":"https://pubmed.ncbi.nlm.nih.gov/40470644/","study_design":null,"title":"Exercise Prescription in Arrhythmogenic Cardiomyopathy: Finding the Right Balance Between Risks and Benefits","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/associations-of-family-history-of-hypertension-genetic-and-lifestyle-40804164","doi":"10.1038/s41440-025-02314-9","journal":"Hypertension Research","n_participants":9001,"pmid":"40804164","source_url":"https://pubmed.ncbi.nlm.nih.gov/40804164/","study_design":"cohort study","title":"Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension","title_match":true,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/contrasting-adult-and-pediatric-populations-in-a-cohort-of-at-risk-40694568","doi":"10.2337/dc25-0192","journal":"Diabetes Care","n_participants":135914,"pmid":"40694568","source_url":"https://pubmed.ncbi.nlm.nih.gov/40694568/","study_design":null,"title":"Contrasting Adult and Pediatric Populations in a Cohort of At-Risk Relatives in The T1D TrialNet Pathway to Prevention Study","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/genetic-correlates-of-presenile-dementia-and-cognitive-decline-in-the-40725212","doi":"10.3390/ijms26146965","journal":"International Journal of Molecular Sciences","n_participants":162,"pmid":"40725212","source_url":"https://pubmed.ncbi.nlm.nih.gov/40725212/","study_design":null,"title":"Genetic Correlates of Presenile Dementia and Cognitive Decline in the Armenian Population Following COVID-19: A Case-Control Study","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/the-burden-of-informal-caregivers-of-people-with-dementia-an-41453398","doi":"10.1002/alz70858_107599","journal":"Alzheimer s & Dementia","n_participants":29,"pmid":"41453398","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12742944/","study_design":null,"title":"The Burden of Informal Caregivers of People with Dementia: An Integrative Review","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/lgbtq-identity-social-support-and-care-access-among-lgbtq-caregivers-40371759","doi":"10.1002/alz.70188","journal":"Alzheimer s & Dementia","n_participants":982,"pmid":"40371759","source_url":"https://pubmed.ncbi.nlm.nih.gov/40371759/","study_design":null,"title":"LGBTQ+ identity social support and care access among LGBTQ+ caregivers of individuals living with mild cognitive impairment, Alzheimer's disease, and related dementias","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/long-term-exposure-to-pm-2-5-constituents-genetic-susceptibility-and-39998422","doi":"10.1021/acs.est.4c08188","journal":"Environmental Science & Technology","n_participants":217336,"pmid":"39998422","source_url":"https://pubmed.ncbi.nlm.nih.gov/39998422/","study_design":null,"title":"Long-Term Exposure to PM 2.5 Constituents, Genetic Susceptibility, and Incident Dementia: A Prospective Cohort Study among 0.2 Million Older Adults","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/polygenic-risk-scores-for-incident-dementia-in-the-multiethnic-study-40093241","doi":"10.1002/gepi.70046","journal":"Genetic Epidemiology","n_participants":null,"pmid":"40093241","source_url":"https://pubmed.ncbi.nlm.nih.gov/40093241/","study_design":null,"title":"Polygenic Risk Scores for Incident Dementia in the Multi\u2010Ethnic Study of Atherosclerosis","title_match":true,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-interaction-between-circadian-syndrome-and-genetic-susceptibility-39922757","doi":"10.1016/j.tjpad.2025.100089","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":null,"pmid":"39922757","source_url":"https://pubmed.ncbi.nlm.nih.gov/39922757/","study_design":null,"title":"The interaction between circadian syndrome and genetic susceptibility in the risk of incident dementia: A longitudinal cohort study","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/knowledge-and-attitudes-about-dementia-and-dementia-genetics-in-a-40261356","doi":"10.1177/13872877251333816","journal":"Journal of Alzheimer s Disease","n_participants":42,"pmid":"40261356","source_url":"https://pubmed.ncbi.nlm.nih.gov/40261356/","study_design":null,"title":"Knowledge and attitudes about dementia and dementia genetics in a cohort of geriatric clinic attendees in Nigeria","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/type-2-diabetes-and-late-onset-alzheimers-disease-and-related-40129417","doi":"10.1177/13872877251326107","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40129417","source_url":"https://pubmed.ncbi.nlm.nih.gov/40129417/","study_design":null,"title":"Type 2 diabetes and late-onset Alzheimer\u2019s disease and related dementia: A longitudinal cohort study integrating polygenic risk score","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/association-of-dietary-diversity-genetic-susceptibility-and-the-risk-39952880","doi":"10.1016/j.tjpad.2025.100078","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":104572,"pmid":"39952880","source_url":"https://pubmed.ncbi.nlm.nih.gov/39952880/","study_design":null,"title":"Association of dietary diversity, genetic susceptibility, and the risk of incident dementia: A prospective cohort study","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/association-between-falls-and-dementia-risk-evidence-from-three-41438467","doi":"10.1515/jtim-2025-0057","journal":"Journal of Translational Internal Medicine","n_participants":265416,"pmid":"41438467","source_url":"https://pubmed.ncbi.nlm.nih.gov/41438467/","study_design":"longitudinal study","title":"Association between falls and dementia risk: Evidence from three cohort studies","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/autism-and-dementia-a-summative-report-from-the-2nd-international-40327233","doi":"10.1007/s10803-025-06843-7","journal":"Journal of Autism and Developmental Disorders","n_participants":null,"pmid":"40327233","source_url":"https://pubmed.ncbi.nlm.nih.gov/40327233/","study_design":null,"title":"Autism and Dementia: A Summative Report from the 2nd International Summit on Intellectual Disabilities and Dementia","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/molecular-features-of-human-pathological-tau-distinguish-tauopathy-41616780","doi":"10.1016/j.cell.2025.12.036","journal":"Cell","n_participants":null,"pmid":"41616780","source_url":"https://pubmed.ncbi.nlm.nih.gov/41616780/","study_design":null,"title":"Molecular features of human pathological tau distinguish tauopathy-associated dementias","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/association-between-plasma-metabolomic-profile-and-machine-40888555","doi":"10.1111/acel.70208","journal":"Aging Cell","n_participants":17770,"pmid":"40888555","source_url":"https://pubmed.ncbi.nlm.nih.gov/40888555/","study_design":null,"title":"Association Between Plasma Metabolomic Profile and Machine Learning\u2010Based Brain Age","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/sleep-disturbances-as-risk-factors-for-neurodegeneration-later-in-life-23640cc9","doi":"10.1038/s44400-025-00008-0","journal":"npj Dementia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1038/s44400-025-00008-0","study_design":null,"title":"Sleep disturbances as risk factors for neurodegeneration later in life","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/social-isolation-loneliness-genetic-risk-and-incident-dementia-in-40438953","doi":"10.1177/13872877251344253","journal":"Journal of Alzheimer s Disease","n_participants":24986,"pmid":"40438953","source_url":"https://pubmed.ncbi.nlm.nih.gov/40438953/","study_design":"longitudinal study","title":"Social isolation, loneliness, genetic risk, and incident dementia in people with type 2 diabetes mellitus: A population-based cohort study","title_match":true,"year":2025},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/deciphering-distinct-genetic-risk-factors-for-ftld-tdp-pathological-40280976","doi":"10.1038/s41467-025-59216-0","journal":"Nature Communications","n_participants":985,"pmid":"40280976","source_url":"https://pubmed.ncbi.nlm.nih.gov/40280976/","study_design":"meta-analysis","title":"Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing","title_match":true,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/white-matter-hyperintensity-spatial-patterns-risk-factors-and-40189793","doi":"10.1002/alz.70053","journal":"Alzheimer s & Dementia","n_participants":2878,"pmid":"40189793","source_url":"https://pubmed.ncbi.nlm.nih.gov/40189793/","study_design":"longitudinal study","title":"White matter hyperintensity spatial patterns: Risk factors and clinical correlates","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/novel-insights-into-alzheimer-s-disease-through-the-study-of-41505228","doi":"10.1002/alz.71074","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41505228","source_url":"https://pubmed.ncbi.nlm.nih.gov/41505228/","study_design":"longitudinal study","title":"Novel insights into Alzheimer's disease through the study of individuals with Down syndrome","title_match":false,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-down-alzheimer-barcelona-neuroimaging-initiative-dabni-ten-years-41518664","doi":"10.1002/alz70856_106426","journal":"Alzheimer s & Dementia","n_participants":1135,"pmid":"41518664","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12790410/","study_design":"longitudinal study","title":"The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI): Ten Years of Progress in Understanding Alzheimer's in Down Syndrome","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/relationship-between-tau-and-sv2a-in-the-neurotypical-population-and-41450092","doi":"10.1002/alz70856_103321","journal":"Alzheimer s & Dementia","n_participants":94,"pmid":"41450092","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12741595/","study_design":null,"title":"Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/relationship-between-tau-and-sv2a-in-the-neurotypical-population-and-41434190","doi":"10.1002/alz70862_110209","journal":"Alzheimer s & Dementia","n_participants":94,"pmid":"41434190","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725288/","study_design":null,"title":"Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/sex-differences-in-the-clinical-manifestation-of-autosomal-dominant-40277077","doi":"10.1002/alz.14630","journal":"Alzheimer s & Dementia","n_participants":337,"pmid":"40277077","source_url":"https://pubmed.ncbi.nlm.nih.gov/40277077/","study_design":"longitudinal study","title":"Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/amyotrophic-lateral-sclerosis-and-frontotemporal-dementia-mutation-40238886","doi":"10.1126/sciadv.ads0505","journal":"Science Advances","n_participants":null,"pmid":"40238886","source_url":"https://pubmed.ncbi.nlm.nih.gov/40238886/","study_design":null,"title":"Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects","title_match":false,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/preclinical-and-prodromal-frontotemporal-dementia-challenges-and-069aac92","doi":"10.3390/ijtm5040052","journal":"International Journal of Translational Medicine","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.3390/ijtm5040052","study_design":null,"title":"Preclinical and Prodromal Frontotemporal Dementia: Challenges and Opportunities","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/frontotemporal-dementia-as-a-consequence-of-grn-mutations-from-40972833","doi":"10.1016/j.phrs.2025.107957","journal":"Pharmacological Research","n_participants":null,"pmid":"40972833","source_url":"https://pubmed.ncbi.nlm.nih.gov/40972833/","study_design":null,"title":"Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies","title_match":false,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/sex-differences-in-the-executive-and-behavioral-reserve-of-autosomal-40277045","doi":"10.1002/alz.70070","journal":"Alzheimer s & Dementia","n_participants":394,"pmid":"40277045","source_url":"https://pubmed.ncbi.nlm.nih.gov/40277045/","study_design":"longitudinal study","title":"Sex differences in the executive and behavioral reserve of autosomal dominant frontotemporal dementia","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/lewy-body-dementia-exploring-biomarkers-and-pathogenic-interactions-40797227","doi":"10.1186/s13024-025-00879-0","journal":"Molecular Neurodegeneration","n_participants":null,"pmid":"40797227","source_url":"https://pubmed.ncbi.nlm.nih.gov/40797227/","study_design":null,"title":"Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid \u03b2, tau, and \u03b1-synuclein","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/impact-of-hypersexuality-on-spousal-carers-of-patients-with-40216419","doi":"10.1136/bmjopen-2024-090870","journal":"BMJ Open","n_participants":null,"pmid":"40216419","source_url":"https://pubmed.ncbi.nlm.nih.gov/40216419/","study_design":null,"title":"Impact of hypersexuality on spousal carers of patients with Parkinson\u2019s disease and frontotemporal dementia: a qualitative study","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/mislocalization-of-nucleic-acids-is-a-convergent-and-targetable-40570368","doi":"10.1016/j.celrep.2025.115867","journal":"Cell Reports","n_participants":null,"pmid":"40570368","source_url":"https://pubmed.ncbi.nlm.nih.gov/40570368/","study_design":null,"title":"Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-experience-of-atrisk-status-for-familial-frontotemporal-dementia-39801084","doi":"10.1002/jgc4.2000","journal":"Journal of Genetic Counseling","n_participants":null,"pmid":"39801084","source_url":"https://pubmed.ncbi.nlm.nih.gov/39801084/","study_design":null,"title":"The experience of \u201cat\u2010risk\u201d status for familial frontotemporal dementia (fFTD) and its impact on reproductive decision\u2010making: A qualitative study","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/novel-approaches-for-the-treatment-of-frontotemporal-dementia-is-40804782","doi":"10.1080/14737175.2025.2546867","journal":"Expert Review of Neurotherapeutics","n_participants":null,"pmid":"40804782","source_url":"https://pubmed.ncbi.nlm.nih.gov/40804782/","study_design":null,"title":"Novel approaches for the treatment of frontotemporal dementia: is there hope for the future?","title_match":false,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/fluid-biomarkers-in-familial-frontotemporal-dementia-progress-and-40901664","doi":"10.3389/fneur.2025.1663609","journal":"Frontiers in Neurology","n_participants":null,"pmid":"40901664","source_url":"https://pubmed.ncbi.nlm.nih.gov/40901664/","study_design":null,"title":"Fluid biomarkers in familial frontotemporal dementia: progress and prospects","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/genetic-contributions-to-alzheimers-disease-and-frontotemporal-41586258","doi":"10.1038/s44400-025-00025-z","journal":"npj Dementia","n_participants":2162,"pmid":"41586258","source_url":"https://pubmed.ncbi.nlm.nih.gov/41586258/","study_design":null,"title":"Genetic contributions to Alzheimer\u2019s disease and frontotemporal dementia in admixed Latin American populations","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/allostatic-load-dynamics-alzheimer-s-disease-biomarkers-and-40606518","doi":"10.1002/dad2.70140","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":385,"pmid":"40606518","source_url":"https://pubmed.ncbi.nlm.nih.gov/40606518/","study_design":null,"title":"Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/comparison-of-deep-learning-and-traditional-machine-learning-models-40141072","doi":"10.3390/ijms26062428","journal":"International Journal of Molecular Sciences","n_participants":239,"pmid":"40141072","source_url":"https://pubmed.ncbi.nlm.nih.gov/40141072/","study_design":null,"title":"Comparison of Deep Learning and Traditional Machine Learning Models for Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-longitudinal-analysis-of-t1-weighted-mri-features-associated-with-42115951","doi":"10.1186/s12880-026-02404-1","journal":"BMC Medical Imaging","n_participants":947,"pmid":"42115951","source_url":"https://pubmed.ncbi.nlm.nih.gov/42115951/","study_design":"longitudinal study","title":"A longitudinal analysis of T1-weighted MRI features associated with progression from mild cognitive impairment to Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/genetic-drivers-of-hippocampal-atrophy-highlight-the-role-of-apoe-41092763","doi":"10.1016/j.nicl.2025.103889","journal":"NeuroImage Clinical","n_participants":1051,"pmid":"41092763","source_url":"https://pubmed.ncbi.nlm.nih.gov/41092763/","study_design":"longitudinal study","title":"Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/secretase-modulation-inhibits-amyloid-plaque-formation-and-growth-and-40054389","doi":"10.1016/j.jpet.2025.103400","journal":"Journal of Pharmacology and Experimental Therapeutics","n_participants":null,"pmid":"40054389","source_url":"https://pubmed.ncbi.nlm.nih.gov/40054389/","study_design":null,"title":"\u03b3-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice","title_match":true,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/mutaciones-en-los-genes-psen1-y-psen2-como-marcadores-moleculares-en-741ba39d","doi":"10.56048/mqr20225.9.3.2025.e946","journal":"MQRInvestigar","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.56048/mqr20225.9.3.2025.e946","study_design":null,"title":"Mutaciones en los genes PSEN1 y PSEN2 como marcadores moleculares en la Enfermedad de Alzheimer. Revisi\u00f3n Sistem\u00e1tica","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/systematic-analysis-of-cellular-cross-talk-reveals-a-role-for-sema6d-40737431","doi":"10.1126/scitranslmed.adx0027","journal":"Science Translational Medicine","n_participants":null,"pmid":"40737431","source_url":"https://pubmed.ncbi.nlm.nih.gov/40737431/","study_design":null,"title":"Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/thymosin-beta-4-as-an-alzheimer-disease-intervention-target-40816274","doi":"10.1016/j.stemcr.2025.102601","journal":"Stem Cell Reports","n_participants":null,"pmid":"40816274","source_url":"https://pubmed.ncbi.nlm.nih.gov/40816274/","study_design":null,"title":"Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/the-er-protein-canx-calnexin-mediated-autophagy-protects-against-39813987","doi":"10.1080/15548627.2024.2447206","journal":"Autophagy","n_participants":null,"pmid":"39813987","source_url":"https://pubmed.ncbi.nlm.nih.gov/39813987/","study_design":null,"title":"The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/presenilin-1-familial-alzheimer-mutations-impair-secretase-cleavage-40723827","doi":"10.3390/biom15070955","journal":"Biomolecules","n_participants":null,"pmid":"40723827","source_url":"https://pubmed.ncbi.nlm.nih.gov/40723827/","study_design":null,"title":"Presenilin-1 Familial Alzheimer Mutations Impair \u03b3-Secretase Cleavage of APP Through Stabilized Enzyme\u2013Substrate Complex Formation","title_match":true,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/cataract-aggravates-alzheimer-like-pathologies-and-cognitive-deficits-40580389","doi":"10.1007/s12264-025-01442-z","journal":"Neuroscience Bulletin","n_participants":null,"pmid":"40580389","source_url":"https://pubmed.ncbi.nlm.nih.gov/40580389/","study_design":null,"title":"Cataract Aggravates Alzheimer-Like Pathologies and Cognitive Deficits in an APP/PS1 Mouse Model","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/alzheimer-mutant-secretase-complexes-stall-amyloid-peptide-production-99d20e91","doi":"10.7554/elife.102274.3","journal":"eLife","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.7554/elife.102274.3","study_design":null,"title":"Alzheimer-mutant \u03b3-secretase complexes stall amyloid \u03b2-peptide production","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-landscape-of-autosomal-dominant-alzheimers-disease-global-39903689","doi":"10.1093/brain/awaf038","journal":"Brain","n_participants":550,"pmid":"39903689","source_url":"https://pubmed.ncbi.nlm.nih.gov/39903689/","study_design":null,"title":"The landscape of autosomal-dominant Alzheimer\u2019s disease: global distribution and age of onset","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-connection-between-autophagy-and-alzheimers-disease-41123674","doi":"10.1007/s00011-025-02118-0","journal":"Inflammation Research","n_participants":null,"pmid":"41123674","source_url":"https://pubmed.ncbi.nlm.nih.gov/41123674/","study_design":null,"title":"The connection between autophagy and Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/a-biophysical-and-molecular-characterization-of-the-interaction-40889683","doi":"10.1016/j.jbc.2025.110665","journal":"Journal of Biological Chemistry","n_participants":null,"pmid":"40889683","source_url":"https://pubmed.ncbi.nlm.nih.gov/40889683/","study_design":null,"title":"A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/cuando-el-alzheimer-llega-antes-de-lo-esperado-la-mutacion-del-gen-752aedc0","doi":"10.32870/ce.vi5.138","journal":"Con Evidencia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.32870/ce.vi5.138","study_design":null,"title":"Cuando el Alzheimer llega antes de lo esperado: la mutaci\u00f3n del gen PSEN1","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/hops-disruption-impairs-app-trafficking-and-processing-promoting-41525887","doi":"10.1016/j.nbd.2026.107269","journal":"Neurobiology of Disease","n_participants":null,"pmid":"41525887","source_url":"https://pubmed.ncbi.nlm.nih.gov/41525887/","study_design":null,"title":"HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs","title_match":false,"year":2026},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/cryoem-structures-of-amyloid-filaments-from-cotton-wool-plaques-in-41435289","doi":"10.1002/alz70855_098033","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41435289","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12726813/","study_design":null,"title":"Cryo\u2010EM structures of amyloid \u03b2 filaments from cotton wool plaques in Alzheimer disease caused by the PSEN1 V261I and A431E mutations","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/phenotypic-characterization-of-recently-identified-psen1-genetic-41433957","doi":"10.1002/alz70861_108984","journal":"Alzheimer s & Dementia","n_participants":61,"pmid":"41433957","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12724748/","study_design":null,"title":"Phenotypic Characterization of Recently Identified PSEN1 Genetic Variants in ADAD in Colombia","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/genetic-association-of-abca7-and-psen1-polymorphisms-with-alzheimers-0c99f57b","doi":"10.2298/abs250208005a","journal":"Archives of Biological Sciences","n_participants":98,"pmid":null,"source_url":"https://doi.org/10.2298/abs250208005a","study_design":"case-control study","title":"Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer\u2019s disease in the northeast Algerian population: Exploring risk factors","title_match":true,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/alzheimer-precoce-fatores-predisponentes-diagnostico-e-manejo-3395e97f","doi":"10.51891/rease.v12i5.26250","journal":"Revista Ibero-Americana de Humanidades, Ci\u00eancias e Educa\u00e7\u00e3o","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.51891/rease.v12i5.26250","study_design":null,"title":"ALZHEIMER PRECOCE: FATORES PREDISPONENTES, DIAGN\u00d3STICO E MANEJO","title_match":false,"year":2026},{"alzhub_score":25,"alzhub_url":"https://alzhub.org/study/enfermedad-de-alzheimer-en-la-mujer-76f633af","doi":"10.36104/amc.2025.4956","journal":"Acta M\u00e9dica Colombiana","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.36104/amc.2025.4956","study_design":null,"title":"Enfermedad de Alzheimer en la mujer","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/imaging-of-the-bone-architecture-in-the-context-of-alzheimer-disease-42622180","doi":"10.1016/j.ostima.2026.100445","journal":"Osteoarthritis Imaging","n_participants":null,"pmid":"42622180","source_url":"https://pubmed.ncbi.nlm.nih.gov/42622180/","study_design":null,"title":"IMAGING OF THE BONE ARCHITECTURE IN THE CONTEXT OF ALZHEIMER DISEASE","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/15-years-of-longitudinal-genetic-clinical-cognitive-imaging-and-41709913","doi":"10.1038/s44400-025-00047-7","journal":"npj Dementia","n_participants":null,"pmid":"41709913","source_url":"https://pubmed.ncbi.nlm.nih.gov/41709913/","study_design":"cohort study","title":"15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN","title_match":false,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/transformative-approaches-to-alzheimer-disease-treatment-current-b059f7db","doi":"10.52783/cana.v32.5141","journal":"Communications on Applied Nonlinear Analysis","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.52783/cana.v32.5141","study_design":null,"title":"\"Transformative Approaches to Alzheimer Disease Treatment: Current Progress and Future Direction\u201d","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/etomidate-ameliorates-alzheimer-like-neuropathology-and-cognitive-40137847","doi":"10.26402/jpp.2025.1.04","journal":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","n_participants":null,"pmid":"40137847","source_url":"https://pubmed.ncbi.nlm.nih.gov/40137847/","study_design":null,"title":"Etomidate ameliorates Alzheimer-like neuropathology and cognitive impairment in APP/PS1 mice","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/crispr-cas9-como-alternativa-terapeutica-para-pacientes-com-doenca-de-b001c286","doi":"10.34024/rnc.2026.v34.19837","journal":"Revista Neuroci\u00eancias","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.34024/rnc.2026.v34.19837","study_design":null,"title":"Crispr/cas9 como alternativa terap\u00eautica para pacientes com doen\u00e7a de Alzheimer: uma revis\u00e3o integrativa","title_match":false,"year":2026},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/quantitative-eeg-obtained-from-dualtask-paradigms-for-the-study-of-41433285","doi":"10.1002/alz70863_110642","journal":"Alzheimer s & Dementia","n_participants":37,"pmid":"41433285","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725696/","study_design":null,"title":"Quantitative EEG obtained from Dual\u2010Task paradigms for the study of preclinical populations at risk of Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/quantitative-eeg-obtained-from-dualtask-paradigms-for-the-study-of-41443245","doi":"10.1002/alz70856_103932","journal":"Alzheimer s & Dementia","n_participants":37,"pmid":"41443245","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12737893/","study_design":null,"title":"Quantitative EEG obtained from Dual\u2010Task paradigms for the study of preclinical populations at risk of Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/cytoplasmic-expression-of-trans-active-response-dna-binding-protein-39864404","doi":"10.1093/jnen/nlae137","journal":"Journal of Neuropathology & Experimental Neurology","n_participants":null,"pmid":"39864404","source_url":"https://pubmed.ncbi.nlm.nih.gov/39864404/","study_design":null,"title":"Cytoplasmic expression of trans-active response DNA-binding protein-43 in aged mice display hippocampal sclerosis-like degeneration and neuronal loss with reduced lifespan","title_match":false,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/presenilin-1-m139i-mutation-regulates-the-microrna-34a-mediated-40286338","doi":"10.1093/jnen/nlaf044","journal":"Journal of Neuropathology & Experimental Neurology","n_participants":null,"pmid":"40286338","source_url":"https://pubmed.ncbi.nlm.nih.gov/40286338/","study_design":null,"title":"Presenilin 1 M139I mutation regulates the microRNA-34a-mediated neurogenic locus notch homolog protein 1 signaling pathway in an early-onset Alzheimer disease cell model","title_match":true,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/neurophysiological-markers-of-cholinergic-dysfunction-in-41434363","doi":"10.1002/alz70861_108702","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41434363","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725564/","study_design":null,"title":"Neurophysiological markers of cholinergic dysfunction in pre\u2010symptomatic autosomal dominant Alzheimer\u00b4s disease using Transcranial Magnetic Stimulation (TMS): research design and preliminary results","title_match":true,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/splenomegaly-spleen-amyloidosis-and-neutrophil-infiltration-are-40906020","doi":"10.1007/s12017-025-08884-8","journal":"NeuroMolecular Medicine","n_participants":null,"pmid":"40906020","source_url":"https://pubmed.ncbi.nlm.nih.gov/40906020/","study_design":null,"title":"Splenomegaly, Spleen Amyloidosis and Neutrophil Infiltration are Present in 3xTg-AD, but not Tg-SwDI Mice","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/epilepsia-como-manifestacion-temprana-en-el-espectro-de-la-enfermedad-5d13b644","doi":"10.22379/anc.v41i4.2037","journal":"Acta neurol\u00f3gica colombiana","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.22379/anc.v41i4.2037","study_design":null,"title":"Epilepsia como manifestaci\u00f3n temprana en el espectro de la enfermedad de Alzheimer: explorando la variante epil\u00e9ptica","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/mas-alla-del-realismo-y-el-constructivismo-el-alzheimer-como-28a35925","doi":"10.17151/difil.2025.26.47.7","journal":"Discusiones Filos\u00f3ficas","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.17151/difil.2025.26.47.7","study_design":null,"title":"M\u00e1s all\u00e1 del realismo y el constructivismo: el Alzheimer como resfactum en una ontolog\u00eda relacional de las entidades biom\u00e9dicas","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/presenilin-2-regulates-corticosterone-induced-autophagic-death-of-da1417b6","doi":"10.6084/m9.figshare.30753007.v1","journal":"Figshare","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.6084/m9.figshare.30753007.v1","study_design":null,"title":"Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells","title_match":true,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/presenilin-2-regulates-corticosterone-induced-autophagic-death-of-bfcd5fd0","doi":"10.6084/m9.figshare.30753007","journal":"Figshare","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.6084/m9.figshare.30753007","study_design":null,"title":"Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells","title_match":true,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/presenilin-2-regulates-corticosterone-induced-autophagic-death-of-41341968","doi":"10.1080/19768354.2025.2589558","journal":"Animal Cells and Systems","n_participants":null,"pmid":"41341968","source_url":"https://pubmed.ncbi.nlm.nih.gov/41341968/","study_design":null,"title":"Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/transcriptomic-analysis-from-3d-cultures-of-presilinin1-g206a-41443185","doi":"10.1002/alz70855_104923","journal":"Alzheimer s & Dementia","n_participants":38577,"pmid":"41443185","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12737914/","study_design":null,"title":"Transcriptomic analysis from 3D cultures of Presilinin\u20101 G206A carriers reveals genetic expression differences associated with age\u2010of\u2010onset variability","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/crisprcas9mediated-genetic-correction-for-alzheimer-s-disease-a-8dfd48d1","doi":"10.5281/zenodo.18032007","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.18032007","study_design":null,"title":"CRISPR\u2013Cas9\u2013Mediated Genetic Correction for Alzheimer's Disease A Hypothetical Therapeutic Framework","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/crisprcas9mediated-genetic-correction-for-alzheimer-s-disease-a-a93d1dcb","doi":"10.5281/zenodo.18032008","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.18032008","study_design":null,"title":"CRISPR\u2013Cas9\u2013Mediated Genetic Correction for Alzheimer's Disease A Hypothetical Therapeutic Framework","title_match":false,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/lymphoid-like-suppressive-microglia-in-alzheimers-disease-a-new-42439628","doi":"10.3390/cells15131151","journal":"Cells","n_participants":null,"pmid":"42439628","source_url":"https://pubmed.ncbi.nlm.nih.gov/42439628/","study_design":null,"title":"Lymphoid-like Suppressive Microglia in Alzheimer\u2019s Disease: A New Neuroimmune Regulatory Axis?","title_match":false,"year":2026},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/baseline-participant-characteristics-in-the-diantu001-trial-41450326","doi":"10.1002/alz70859_105299","journal":"Alzheimer s & Dementia","n_participants":243,"pmid":"41450326","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12741730/","study_design":null,"title":"Baseline Participant Characteristics in the DIAN\u2010TU\u2010001 Trial","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/contribution-of-genetic-and-lifestyle-factors-in-resistance-and-41447325","doi":"10.1002/alz70856_101525","journal":"Alzheimer s & Dementia","n_participants":529,"pmid":"41447325","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12739984/","study_design":"longitudinal study","title":"Contribution of genetic and lifestyle factors in resistance\u2010 and resilience\u2010related variability in longitudinal pathologic and neurodegeneration trajectory in Dominantly Inherited Alzheimer's Disease","title_match":true,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/challenges-in-the-identification-of-underlying-pathologies-in-a216cab1","doi":"10.1002/alz70856_106350","journal":"Alzheimer s & Dementia","n_participants":20,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106350","study_design":null,"title":"Challenges in the identification of underlying pathologies in dementias with predominant behavioral phenotype using laboratory biomarkers","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/clinical-progression-on-cdrsb-progressionfree-time-at-each-0-5-unit-40911712","doi":"10.1002/alz.70643","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40911712","source_url":"https://pubmed.ncbi.nlm.nih.gov/40911712/","study_design":"open-label trial","title":"Clinical progression on CDR\u2010SB\u00a9: Progression\u2010free time at each 0.5 unit level in dominantly inherited and sporadic Alzheimer's disease populations","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/deciding-on-genetic-testing-for-familial-dementia-perspectives-of-40189825","doi":"10.1002/alz.70140","journal":"Alzheimer s & Dementia","n_participants":15,"pmid":"40189825","source_url":"https://pubmed.ncbi.nlm.nih.gov/40189825/","study_design":null,"title":"Deciding on genetic testing for familial dementia: Perspectives of patients and families","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-polygenic-risks-association-with-all-cause-40588577","doi":"10.1007/s11357-025-01724-4","journal":"GeroScience","n_participants":249,"pmid":"40588577","source_url":"https://pubmed.ncbi.nlm.nih.gov/40588577/","study_design":null,"title":"Alzheimer\u2019s disease polygenic risk\u2019s association with all-cause dementia through the plasma metabolome in the UK Biobank study","title_match":true,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/age-at-diabetes-diagnosis-genetic-susceptibility-and-dementia-risk-a-5709812f","doi":"10.1016/j.medp.2025.100111","journal":"Medicine Plus","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.medp.2025.100111","study_design":null,"title":"Age at diabetes diagnosis, genetic susceptibility and dementia risk: a prospective study of 13,126 participants from the UK Biobank","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/oral-health-genetic-susceptibility-and-risk-of-dementia-a-prospective-42168726","doi":"10.1007/s11357-026-02316-6","journal":"GeroScience","n_participants":7553,"pmid":"42168726","source_url":"https://pubmed.ncbi.nlm.nih.gov/42168726/","study_design":"cohort study","title":"Oral health, genetic susceptibility, and risk of dementia: a prospective cohort study of UK Biobank","title_match":false,"year":2026},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/liver-diseases-and-brain-disorders-genetic-mechanisms-and-biomarker-40230026","doi":"10.1111/jnc.70066","journal":"Journal of Neurochemistry","n_participants":59,"pmid":"40230026","source_url":"https://pubmed.ncbi.nlm.nih.gov/40230026/","study_design":"cohort study","title":"Liver Diseases and Brain Disorders: Genetic Mechanisms and Biomarker Pathways in a Prospective Cohort Study From the UK Biobank","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/integrated-roles-of-systemic-diseases-and-serum-biomarkers-in-the-f0768c81","doi":"10.1002/mdb2.70008","journal":"Medicine Bulletin","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1002/mdb2.70008","study_design":null,"title":"Integrated Roles of Systemic Diseases and Serum Biomarkers in the Incidence of Age\u2010Related Macular Degeneration: The UK Biobank Study","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/crosssectional-study-of-plasma-phosphorylated-tau-217-in-persons-40352683","doi":"10.1002/dad2.70107","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":697,"pmid":"40352683","source_url":"https://pubmed.ncbi.nlm.nih.gov/40352683/","study_design":null,"title":"Cross\u2010sectional study of plasma phosphorylated tau 217 in persons without dementia","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/association-of-heel-bone-mineral-density-with-incident-dementia-among-40668308","doi":"10.1007/s40520-025-03100-w","journal":"Aging Clinical and Experimental Research","n_participants":131030,"pmid":"40668308","source_url":"https://pubmed.ncbi.nlm.nih.gov/40668308/","study_design":"cohort study","title":"Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/parenchymal-and-dyshoric-fibrillar-amyloid-pathology-in-the-rtg-d-rat-40683561","doi":"10.1016/j.ajpath.2025.06.008","journal":"American Journal Of Pathology","n_participants":null,"pmid":"40683561","source_url":"https://pubmed.ncbi.nlm.nih.gov/40683561/","study_design":null,"title":"Parenchymal and Dyshoric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/als-and-huntington-disease-unraveling-the-connections-between-tdp-43-41813136","doi":"10.1523/jneurosci.0263-25.2026","journal":"Journal of Neuroscience","n_participants":null,"pmid":"41813136","source_url":"https://pubmed.ncbi.nlm.nih.gov/41813136/","study_design":null,"title":"ALS and Huntington Disease: Unraveling the Connections between TDP-43 and Huntingtin","title_match":false,"year":2026},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/assessing-colocalization-of-itm2b-with-alzheimer-s-disease-and-40042444","doi":"10.1111/neup.70003","journal":"Neuropathology","n_participants":null,"pmid":"40042444","source_url":"https://pubmed.ncbi.nlm.nih.gov/40042444/","study_design":null,"title":"Assessing Co\u2010Localization of ITM2B With Alzheimer's Disease and Limbic\u2010Predominant Age\u2010Related TDP \u201043 Encephalopathy Neuropathologic Changes","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-de-novo-mosaic-and-complex-chromosome-21-rearrangement-causes-app-39849058","doi":"10.1038/s41598-025-86645-0","journal":"Scientific Reports","n_participants":null,"pmid":"39849058","source_url":"https://pubmed.ncbi.nlm.nih.gov/39849058/","study_design":null,"title":"A de novo, mosaic and complex chromosome 21 rearrangement causes APP triplication and familial autosomal dominant early onset Alzheimer disease","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/neuroinflammation-and-alzheimer-s-disease-unravelling-the-molecular-40938771","doi":"10.1177/13872877251374353","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40938771","source_url":"https://pubmed.ncbi.nlm.nih.gov/40938771/","study_design":null,"title":"Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/human-ipsc-derived-apoe4-4-alzheimer-s-disease-astrocytes-exhibit-a-41388301","doi":"10.1186/s12974-025-03607-z","journal":"Journal of Neuroinflammation","n_participants":null,"pmid":"41388301","source_url":"https://pubmed.ncbi.nlm.nih.gov/41388301/","study_design":null,"title":"Human iPSC-derived APOE4/4 Alzheimer\u00b4s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/semaglutide-improves-cognitive-function-and-neuroinflammation-in-app-40151913","doi":"10.1177/13872877251329439","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40151913","source_url":"https://pubmed.ncbi.nlm.nih.gov/40151913/","study_design":null,"title":"Semaglutide improves cognitive function and neuroinflammation in APP/PS1 transgenic mice by activating AMPK and inhibiting TLR4/NF-\u03baB pathway","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-brain-neurovascular-epigenome-and-its-association-with-dementia-41173000","doi":"10.1016/j.neuron.2025.10.001","journal":"Neuron","n_participants":null,"pmid":"41173000","source_url":"https://pubmed.ncbi.nlm.nih.gov/41173000/","study_design":null,"title":"The brain neurovascular epigenome and its association with dementia","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/convergence-of-neuroinflammation-across-major-neurotropic-viral-42215997","doi":"10.1186/s12974-026-03876-2","journal":"Journal of Neuroinflammation","n_participants":null,"pmid":"42215997","source_url":"https://pubmed.ncbi.nlm.nih.gov/42215997/","study_design":null,"title":"Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/molecular-crossroads-shared-and-divergent-molecular-signatures-in-41465242","doi":"10.3390/ijms262411811","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"41465242","source_url":"https://pubmed.ncbi.nlm.nih.gov/41465242/","study_design":null,"title":"Molecular Crossroads: Shared and Divergent Molecular Signatures in Alzheimer\u2019s Disease and Dementia with Lewy Bodies","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/selective-association-of-eeg-microstates-with-clinical-symptoms-and-41005266","doi":"10.1016/j.nicl.2025.103879","journal":"NeuroImage Clinical","n_participants":99,"pmid":"41005266","source_url":"https://pubmed.ncbi.nlm.nih.gov/41005266/","study_design":null,"title":"Selective association of EEG microstates with clinical symptoms and mutation status in monogenic Alzheimer disease","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/mapt-splicing-modulators-reduce-4r-tau-and-rescue-tauopathy-42616837","doi":"10.1126/scitranslmed.ady6759","journal":"Science Translational Medicine","n_participants":null,"pmid":"42616837","source_url":"https://pubmed.ncbi.nlm.nih.gov/42616837/","study_design":null,"title":"MAPT splicing modulators reduce 4R tau and rescue tauopathy phenotypes in human neurons and in a mouse model","title_match":false,"year":2026},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/pathological-mechanisms-and-treatment-progression-of-alzheimers-40660381","doi":"10.1186/s40001-025-02886-9","journal":"European journal of medical research","n_participants":null,"pmid":"40660381","source_url":"https://pubmed.ncbi.nlm.nih.gov/40660381/","study_design":null,"title":"Pathological mechanisms and treatment progression of Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/co-occurrence-of-multiple-pathologies-in-a-case-of-frontotemporal-40713844","doi":"10.1186/s40478-025-02081-1","journal":"Acta Neuropathologica Communications","n_participants":null,"pmid":"40713844","source_url":"https://pubmed.ncbi.nlm.nih.gov/40713844/","study_design":null,"title":"Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe-calypse-tau-apoetau-synergy-in-alzheimers-disease-40856646","doi":"10.1084/jem.20250965","journal":"The Journal of Experimental Medicine","n_participants":null,"pmid":"40856646","source_url":"https://pubmed.ncbi.nlm.nih.gov/40856646/","study_design":null,"title":"ApoE-calypse tau: ApoE\u2013tau synergy in Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/multi-functional-role-of-apolipoprotein-e-in-neurodegenerative-39944166","doi":"10.3389/fnagi.2025.1535280","journal":"Frontiers in Aging Neuroscience","n_participants":null,"pmid":"39944166","source_url":"https://pubmed.ncbi.nlm.nih.gov/39944166/","study_design":null,"title":"Multi-functional role of apolipoprotein E in neurodegenerative diseases","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/organ-specific-proteomic-aging-clocks-predict-disease-and-longevity-41299092","doi":"10.1038/s43587-025-01016-8","journal":"Nature Aging","n_participants":43616,"pmid":"41299092","source_url":"https://pubmed.ncbi.nlm.nih.gov/41299092/","study_design":null,"title":"Organ-specific proteomic aging clocks predict disease and longevity across diverse populations","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/insights-from-tgf344-ad-a-double-transgenic-rat-model-in-alzheimers-40116546","doi":"10.33549/physiolres.935464","journal":"Physiological Research","n_participants":null,"pmid":"40116546","source_url":"https://pubmed.ncbi.nlm.nih.gov/40116546/","study_design":null,"title":"Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer\u2019s Disease Research","title_match":false,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-basics-we-all-should-know-40639927","doi":"10.1080/01616412.2025.2529560","journal":"Neurological Research","n_participants":null,"pmid":"40639927","source_url":"https://pubmed.ncbi.nlm.nih.gov/40639927/","study_design":null,"title":"Alzheimer\u2019s disease basics: we all should know","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-structural-haplotype-in-the-17q21-31-mapt-region-is-associated-with-40239644","doi":"10.1016/j.xcrm.2025.102084","journal":"Cell Reports Medicine","n_participants":null,"pmid":"40239644","source_url":"https://pubmed.ncbi.nlm.nih.gov/40239644/","study_design":null,"title":"A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/genetic-background-and-multidomain-interventions-in-mild-cognitive-40490801","doi":"10.1186/s13195-025-01764-0","journal":"Alzheimer s Research & Therapy","n_participants":289,"pmid":"40490801","source_url":"https://pubmed.ncbi.nlm.nih.gov/40490801/","study_design":null,"title":"Genetic background and multidomain interventions in mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/dementia-risk-literacy-in-older-australians-beyond-knowledge-41134115","doi":"10.1071/pu24108","journal":"Public Health Research & Practice","n_participants":null,"pmid":"41134115","source_url":"https://pubmed.ncbi.nlm.nih.gov/41134115/","study_design":"cohort study","title":"Dementia risk literacy in older Australians: beyond knowledge","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-genetic-architecture-of-postoperative-delirium-after-major-41770756","doi":"10.1371/journal.pmed.1004963","journal":"PLoS Medicine","n_participants":null,"pmid":"41770756","source_url":"https://pubmed.ncbi.nlm.nih.gov/41770756/","study_design":"case-control study","title":"The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study","title_match":false,"year":2026},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/advance-care-planning-intention-and-associated-factors-among-people-41823305","doi":"10.1111/jan.70521","journal":"Journal of Advanced Nursing","n_participants":null,"pmid":"41823305","source_url":"https://pubmed.ncbi.nlm.nih.gov/41823305/","study_design":null,"title":"Advance Care Planning Intention and Associated Factors Among People With Dementia: A Mixed\u2010Methods Study","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/endothelial-progenitor-cells-and-cerebral-small-vessel-disease-in-40034682","doi":"10.1016/j.cccb.2025.100378","journal":"Cerebral Circulation - Cognition and Behavior","n_participants":109,"pmid":"40034682","source_url":"https://pubmed.ncbi.nlm.nih.gov/40034682/","study_design":null,"title":"Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/unravelling-the-genetic-architecture-of-cerebral-small-vessel-disease-40770913","doi":"10.1177/0271678x251362977","journal":"Journal of Cerebral Blood Flow & Metabolism","n_participants":null,"pmid":"40770913","source_url":"https://pubmed.ncbi.nlm.nih.gov/40770913/","study_design":null,"title":"Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/multi-ancestry-transcriptome-wide-association-studies-of-cognitive-40141087","doi":"10.3390/ijms26062443","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"40141087","source_url":"https://pubmed.ncbi.nlm.nih.gov/40141087/","study_design":null,"title":"Multi-Ancestry Transcriptome-Wide Association Studies of Cognitive Function, White Matter Hyperintensity, and Alzheimer\u2019s Disease","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/light-chain-split-luciferase-assay-implicates-pathological-notch3-39864627","doi":"10.1016/j.jbc.2025.108224","journal":"Journal of Biological Chemistry","n_participants":null,"pmid":"39864627","source_url":"https://pubmed.ncbi.nlm.nih.gov/39864627/","study_design":null,"title":"Light-chain split luciferase assay implicates pathological NOTCH3 thiol reactivity in inherited cerebral small vessel disease","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/polygenic-risk-for-white-matter-hyperintensities-is-associated-with-41561329","doi":"10.3389/fneur.2025.1667424","journal":"Frontiers in Neurology","n_participants":1072,"pmid":"41561329","source_url":"https://pubmed.ncbi.nlm.nih.gov/41561329/","study_design":null,"title":"Polygenic risk for white matter hyperintensities is associated with early cerebrovascular events partly through hemodynamic measures in cognitively unimpaired middle-aged and older adults with low cardiovascular risk","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/gch1-genetic-variation-as-a-prognostic-factor-in-parkinsons-disease-a566b431","doi":"10.64898/2026.08.14.26359677","journal":"medRxiv (preprint)","n_participants":22825,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.14.26359677","study_design":"longitudinal study","title":"GCH1 genetic variation as a prognostic factor in Parkinsons disease across populations","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/long-read-sequencing-reveals-hidden-structural-complexity-within-d8615865","doi":"10.64898/2026.03.16.26348487","journal":"medRxiv (preprint)","n_participants":493,"pmid":null,"source_url":"https://doi.org/10.64898/2026.03.16.26348487","study_design":null,"title":"Long-read sequencing reveals hidden structural complexity within Alzheimers disease-associated GWAS loci","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-architecture-of-alzheimer-s-disease-is-enriched-in-peripheral-6c8e9111","doi":"10.64898/2026.02.09.26344392","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.02.09.26344392","study_design":null,"title":"Genetic architecture of Alzheimer's disease is enriched in peripheral immune and metabolic programs","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/conditional-polygenic-enrichment-distinguishes-causal-from-tagging-c0254966","doi":"10.64898/2026.08.20.26360914","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.20.26360914","study_design":null,"title":"Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seq","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/participant-attitudes-toward-returning-individual-results-from-09e906a4","doi":"10.64898/2026.08.21.26361045","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.21.26361045","study_design":null,"title":"Participant attitudes toward returning individual results from CADASIL research","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/adult-vaccination-history-and-plasma-biomarker-signatures-in-the-179bc140","doi":"10.64898/2026.08.24.26361238","journal":"medRxiv (preprint)","n_participants":192,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.24.26361238","study_design":"longitudinal study","title":"Adult Vaccination History and Plasma Biomarker Signatures in the Asymptomatic PREVENT-AD Cohort","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/absorption-and-co-expression-modules-show-where-polygenic-and-e4fc5f6b","doi":"10.64898/2026.08.24.26361271","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.24.26361271","study_design":null,"title":"Absorption and Co-expression Modules Show Where Polygenic and Proteomic Risk Scores Diverge in Neurodegenerative Diseases","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/integrative-multi-omics-qtl-colocalization-maps-regulatory-517396ca","doi":"10.1101/2025.04.17.25326042","journal":"medRxiv (preprint)","n_participants":595,"pmid":null,"source_url":"https://doi.org/10.1101/2025.04.17.25326042","study_design":null,"title":"Integrative multi-omics QTL colocalization maps regulatory architecture in aging human brain","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/systematic-modality-ablation-of-multimodal-machine-learning-for-c0e87325","doi":"10.64898/2026.09.01.26360413","journal":"medRxiv (preprint)","n_participants":2430,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.01.26360413","study_design":null,"title":"Systematic Modality Ablation of Multimodal Machine Learning for Predicting 24-Month Progression from Mild Cognitive Impairment to Alzheimer's Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/ancestry-specific-effects-of-apoe-on-alzheimer-disease-endophenotypes-52d13682","doi":"10.64898/2026.03.23.26349095","journal":"medRxiv (preprint)","n_participants":2733,"pmid":null,"source_url":"https://doi.org/10.64898/2026.03.23.26349095","study_design":null,"title":"Ancestry-specific effects of APOE on Alzheimer Disease Endophenotypes","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/alzheimer-s-polygenic-risk-scores-are-not-interchangeable-evidence-3ac879df","doi":"10.64898/2026.09.02.26362060","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.02.26362060","study_design":null,"title":"Alzheimer's Polygenic Risk Scores Are Not Interchangeable: Evidence from 1,752 Models","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/machine-learning-derived-alzheimer-s-disease-dimensions-bf822a70","doi":"10.64898/2026.09.02.26361668","journal":"medRxiv (preprint)","n_participants":393,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.02.26361668","study_design":null,"title":"Machine learning-derived Alzheimer's disease dimensions: neuroanatomical, cognitive, clinical, functional, and genetic risk heterogeneity signatures","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/shared-genetic-architecture-between-brain-iron-deposition-and-260cf6f2","doi":"10.64898/2026.09.07.26362470","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.07.26362470","study_design":null,"title":"Shared genetic architecture between brain iron deposition and Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/rare-extreme-polygenic-risk-scores-strongly-indicate-alzheimer-s-c1a7a162","doi":"10.64898/2026.09.08.26362504","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.08.26362504","study_design":null,"title":"Rare extreme polygenic risk scores strongly indicate Alzheimer's disease risk","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/sex-aware-cross-tissue-regulatory-transformer-identified-sexually-ba023161","doi":"10.64898/2026.09.08.26362488","journal":"medRxiv (preprint)","n_participants":449335,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.08.26362488","study_design":null,"title":"Sex-aware Cross-tissue Regulatory Transformer Identified Sexually Dimorphic Alzheimer's Disease Risk Loci and Causal Cellular Circuit","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/multi-trait-polygenic-profiling-and-survival-free-of-dementia-and-e05c6a7d","doi":"10.64898/2026.09.09.26362686","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.09.26362686","study_design":"longitudinal study","title":"Multi-trait Polygenic Profiling and Survival Free of Dementia and Disability: Results from the Health and Retirement Study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/amyloid-independent-elevation-of-plasma-phosphorylated-tau-217-tracks-f0e62b39","doi":"10.64898/2026.09.09.26362677","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.09.26362677","study_design":null,"title":"Amyloid-Independent Elevation of Plasma phosphorylated tau-217 Tracks Neurodegenerative Risk in Tuberous Sclerosis Complex: Implications for mTOR-Targeted Intervention","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/pathway-specific-polygenic-risk-scores-reveal-underlying-mechanisms-6c3e8264","doi":"10.64898/2026.09.10.26360585","journal":"medRxiv (preprint)","n_participants":46944,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.10.26360585","study_design":null,"title":"Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-apol1-protective-m1-modifier-occurs-exclusively-with-the-kik-a81a35f6","doi":"10.64898/2026.09.14.26362999","journal":"medRxiv (preprint)","n_participants":40909,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.14.26362999","study_design":null,"title":"The APOL1 protective M1 modifier occurs exclusively with the KIK protein haplotype to suppress channel conductance","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/population-scale-burden-analysis-of-rare-damaging-coding-variants-c49638e3","doi":"10.64898/2026.03.03.26347540","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.03.03.26347540","study_design":null,"title":"Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer's disease and related dementias and Parkinson's disease and related disorders","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/heritability-and-rare-variant-contributions-to-alzheimer-disease-in-cab8ac54","doi":"10.64898/2026.09.17.26363309","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.17.26363309","study_design":null,"title":"Heritability and rare variant contributions to Alzheimer disease in the Midwestern Amish","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-longitudinal-study-of-age-related-traits-and-cognitive-function-the-1633fa73","doi":"10.64898/2026.09.17.26363351","journal":"medRxiv (preprint)","n_participants":3978,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.17.26363351","study_design":"prospective cohort","title":"A longitudinal study of age-related traits and cognitive function: The Collaborative Amish Aging and Memory Project (CAAMP)","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetically-predicted-blood-dna-methylation-reveals-putative-a7c7238d","doi":"10.64898/2026.09.17.26363319","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.17.26363319","study_design":null,"title":"Genetically Predicted Blood DNA Methylation Reveals Putative Regulatory Signals Associated with ALS Risk","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/clinical-and-attitudinal-outcomes-of-a-personalized-multimodal-4286e09f","doi":"10.64898/2026.09.19.26363495","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.19.26363495","study_design":null,"title":"Clinical and attitudinal outcomes of a personalized, multimodal lifestyle intervention for Alzheimer's disease prevention in high-risk, cognitively normal older adults in north Alabama: A pilot study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-value-of-a-family-history-to-distinguish-monogenic-from-polygenic-11d44251","doi":"10.64898/2026.09.16.26362994","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.16.26362994","study_design":null,"title":"The value of a family history to distinguish monogenic from polygenic amyotrophic lateral sclerosis","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/higher-neighborhood-deprivation-is-associated-with-accelerated-40463548","doi":"10.1101/2025.05.12.25327099","journal":"Alzheimer's & dementia. Behavior & socioeconomics of aging","n_participants":161,"pmid":"40463548","source_url":"https://pubmed.ncbi.nlm.nih.gov/40463548/","study_design":"longitudinal study","title":"Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/integrating-machine-learning-and-environmental-and-genetic-risk-39969227","doi":"10.1093/geronb/gbaf023","journal":"The journals of gerontology. Series B, Psychological sciences and social sciences","n_participants":2792,"pmid":"39969227","source_url":"https://pubmed.ncbi.nlm.nih.gov/39969227/","study_design":"longitudinal study","title":"Integrating Machine Learning and Environmental and Genetic Risk Factors for the Early Detection of Preclinical Alzheimer's Disease","title_match":true,"year":2025},{"alzhub_score":24,"alzhub_url":"https://alzhub.org/study/food-priorities-sociodemographic-variation-in-constrained-choices-at-00adaa80","doi":"10.1108/s1057-629020170000018004","journal":"Food Systems and Health","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1108/s1057-629020170000018004","study_design":null,"title":"Food Priorities: Sociodemographic Variation in Constrained Choices at the Grocery Store","title_match":false,"year":2017},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/gene-dose-of-apolipoprotein-e-type-4-allele-and-the-risk-of-alzheimer-8346443","doi":"10.1126/science.8346443","journal":"Science","n_participants":null,"pmid":"8346443","source_url":"https://pubmed.ncbi.nlm.nih.gov/8346443/","study_design":null,"title":"Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families","title_match":false,"year":1993},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/clinical-and-biomarker-changes-in-dominantly-inherited-alzheimer-s-22784036","doi":"10.1056/nejmoa1202753","journal":"New England Journal of Medicine","n_participants":128,"pmid":"22784036","source_url":"https://pubmed.ncbi.nlm.nih.gov/22784036/","study_design":"cross-sectional","title":"Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease","title_match":true,"year":2012},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/association-of-apolipoprotein-e-allele-4-with-lateonset-familial-and-8350998","doi":"10.1212/wnl.43.8.1467","journal":"Neurology","n_participants":null,"pmid":"8350998","source_url":"https://pubmed.ncbi.nlm.nih.gov/8350998/","study_design":null,"title":"Association of apolipoprotein E allele \u03f54 with late\u2010onset familial and sporadic Alzheimer's disease","title_match":true,"year":1993},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/segregation-of-a-missense-mutation-in-the-amyloid-precursor-protein-1671712","doi":"10.1038/349704a0","journal":"Nature","n_participants":null,"pmid":"1671712","source_url":"https://pubmed.ncbi.nlm.nih.gov/1671712/","study_design":null,"title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease","title_match":true,"year":1991},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/consortium-to-establish-a-registry-for-alzheimer-s-disease-cerad-ac049f00","doi":"10.1002/0470846410.ch42(iii)","journal":"Principles and Practice of Geriatric Psychiatry","n_participants":1000,"pmid":null,"source_url":"https://doi.org/10.1002/0470846410.ch42(iii)","study_design":"longitudinal study","title":"Consortium to Establish a Registry for Alzheimer's Disease (CERAD)","title_match":false,"year":2002},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/cloning-of-a-gene-bearing-missense-mutations-in-early-onset-familial-7596406","doi":"10.1038/375754a0","journal":"Nature","n_participants":null,"pmid":"7596406","source_url":"https://pubmed.ncbi.nlm.nih.gov/7596406/","study_design":null,"title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","title_match":true,"year":1995},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/the-amyloid-hypothesis-of-alzheimer-s-disease-at-25-years-27025652","doi":"10.15252/emmm.201606210","journal":"EMBO Molecular Medicine","n_participants":null,"pmid":"27025652","source_url":"https://pubmed.ncbi.nlm.nih.gov/27025652/","study_design":null,"title":"The amyloid hypothesis of Alzheimer's disease at 25 years","title_match":false,"year":2016},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/intraneuronal-amyloid-aggregates-neurodegeneration-and-neuron-loss-in-17021169","doi":"10.1523/jneurosci.1202-06.2006","journal":"Journal of Neuroscience","n_participants":null,"pmid":"17021169","source_url":"https://pubmed.ncbi.nlm.nih.gov/17021169/","study_design":null,"title":"Intraneuronal \u03b2-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation","title_match":true,"year":2006},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genes-proteins-and-therapy-11274343","doi":"10.1152/physrev.2001.81.2.741","journal":"Physiological Reviews","n_participants":null,"pmid":"11274343","source_url":"https://pubmed.ncbi.nlm.nih.gov/11274343/","study_design":null,"title":"Alzheimer's Disease: Genes, Proteins, and Therapy","title_match":false,"year":2001},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/tdp-43-mutations-in-familial-and-sporadic-amyotrophic-lateral-18309045","doi":"10.1126/science.1154584","journal":"Science","n_participants":null,"pmid":"18309045","source_url":"https://pubmed.ncbi.nlm.nih.gov/18309045/","study_design":null,"title":"TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis","title_match":true,"year":2008},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/association-between-single-moderate-to-severe-traumatic-brain-injury-35101132","doi":"10.1186/s40478-022-01311-0","journal":"Acta neuropathologica communications","n_participants":12,"pmid":"35101132","source_url":"https://pubmed.ncbi.nlm.nih.gov/35101132/","study_design":"narrative review","title":"Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature","title_match":false,"year":2022},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/secretase-activity-clinical-features-and-biomarkers-of-autosomal-39074479","doi":"10.1016/s1474-4422(24)00236-9","journal":"The Lancet. Neurology","n_participants":190,"pmid":"39074479","source_url":"https://pubmed.ncbi.nlm.nih.gov/39074479/","study_design":"cross-sectional","title":"\u03b3-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/genetic-variants-associated-with-alzheimer-disease-in-the-22-arab-33769987","doi":"10.1097/wad.0000000000000447","journal":"Alzheimer disease and associated disorders","n_participants":2173,"pmid":"33769987","source_url":"https://pubmed.ncbi.nlm.nih.gov/33769987/","study_design":"systematic review","title":"Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries: A Systematic Review","title_match":false,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/location-of-pathogenic-variants-in-psen1-impacts-progression-of-37291760","doi":"10.1111/acel.13871","journal":"Aging cell","n_participants":null,"pmid":"37291760","source_url":"https://pubmed.ncbi.nlm.nih.gov/37291760/","study_design":"cross-sectional","title":"Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/retinal-imaging-findings-in-carriers-with-psen1-associated-early-33180114","doi":"10.1001/jamaophthalmol.2020.4909","journal":"JAMA ophthalmology","n_participants":null,"pmid":"33180114","source_url":"https://pubmed.ncbi.nlm.nih.gov/33180114/","study_design":"cross-sectional","title":"Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms","title_match":true,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-and-deposits-of-abeta40-and-abeta42-in-9678319","doi":"10.1001/archneur.55.7.1001","journal":"Archives of neurology","n_participants":null,"pmid":"9678319","source_url":"https://pubmed.ncbi.nlm.nih.gov/9678319/","study_design":"clinical trial","title":"Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease","title_match":false,"year":1998},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/screening-for-mutations-of-the-precursor-of-beta-amyloid-protein-in-8023065","doi":null,"journal":"Revue neurologique","n_participants":null,"pmid":"8023065","source_url":"https://pubmed.ncbi.nlm.nih.gov/8023065/","study_design":"clinical trial","title":"[Screening for mutations of the precursor of beta-amyloid protein in early forms of Alzheimer disease. French Study Group of Alzheimer Disease]","title_match":false,"year":1993},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/human-induced-pluripotent-stem-cell-models-for-alzheimer-s-disease-40177166","doi":"10.3389/fnhum.2025.1548701","journal":"Frontiers in human neuroscience","n_participants":null,"pmid":"40177166","source_url":"https://pubmed.ncbi.nlm.nih.gov/40177166/","study_design":"systematic review","title":"Human induced pluripotent stem cell models for Alzheimer's disease research: a bibliometric analysis","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/molecular-mechanisms-linking-type-2-diabetes-mellitus-and-late-onset-38643861","doi":"10.1016/j.nbd.2024.106485","journal":"Neurobiology of disease","n_participants":null,"pmid":"38643861","source_url":"https://pubmed.ncbi.nlm.nih.gov/38643861/","study_design":"systematic review","title":"Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis","title_match":false,"year":2024},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/adult-onset-leukoencephalopathy-with-axonal-spheroids-and-pigmented-29122458","doi":"10.1016/j.jocn.2017.10.060","journal":"Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia","n_participants":null,"pmid":"29122458","source_url":"https://pubmed.ncbi.nlm.nih.gov/29122458/","study_design":"systematic review","title":"Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Integrating the literature on hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD)","title_match":false,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/bioface-a-prospective-study-of-risk-factors-cognition-and-biomarkers-34420953","doi":"10.3233/jad-210254","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34420953","source_url":"https://pubmed.ncbi.nlm.nih.gov/34420953/","study_design":null,"title":"BIOFACE: A Prospective Study of Risk Factors, Cognition, and Biomarkers in a Cohort of Individuals with Early-Onset Mild Cognitive Impairment. Study Rationale and Research Protocols","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/secreted-amyloid-protein-similar-to-that-in-the-senile-plaques-of-8705854","doi":"10.1038/nm0896-864","journal":"Nature Medicine","n_participants":null,"pmid":"8705854","source_url":"https://pubmed.ncbi.nlm.nih.gov/8705854/","study_design":null,"title":"Secreted amyloid \u03b2\u2013protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease","title_match":true,"year":1996},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/criteria-for-the-diagnosis-of-corticobasal-degeneration-23359374","doi":"10.1212/wnl.0b013e31827f0fd1","journal":"Neurology","n_participants":null,"pmid":"23359374","source_url":"https://pubmed.ncbi.nlm.nih.gov/23359374/","study_design":null,"title":"Criteria for the diagnosis of corticobasal degeneration","title_match":false,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/candidate-gene-for-the-chromosome-1-familial-alzheimer-s-disease-locus-7638622","doi":"10.1126/science.7638622","journal":"Science","n_participants":null,"pmid":"7638622","source_url":"https://pubmed.ncbi.nlm.nih.gov/7638622/","study_design":null,"title":"Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus","title_match":true,"year":1995},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/fibrillar-amyloid-burden-in-cognitively-normal-people-at-3-levels-of-19346482","doi":"10.1073/pnas.0900345106","journal":"Proceedings of the National Academy of Sciences","n_participants":null,"pmid":"19346482","source_url":"https://pubmed.ncbi.nlm.nih.gov/19346482/","study_design":null,"title":"Fibrillar amyloid-\u03b2 burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease","title_match":true,"year":2009},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/human-apoe-isoforms-differentially-regulate-brain-amyloid-peptide-21715678","doi":"10.1126/scitranslmed.3002156","journal":"Science Translational Medicine","n_participants":null,"pmid":"21715678","source_url":"https://pubmed.ncbi.nlm.nih.gov/21715678/","study_design":null,"title":"Human apoE Isoforms Differentially Regulate Brain Amyloid-\u03b2 Peptide Clearance","title_match":false,"year":2011},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/mutation-in-the-synuclein-gene-identified-in-families-with-parkinson-9197268","doi":"10.1126/science.276.5321.2045","journal":"Science","n_participants":null,"pmid":"9197268","source_url":"https://pubmed.ncbi.nlm.nih.gov/9197268/","study_design":null,"title":"Mutation in the \u03b1-Synuclein Gene Identified in Families with Parkinson's Disease","title_match":false,"year":1997},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-disease-in-kindreds-with-missense-mutations-in-a-7651536","doi":"10.1038/376775a0","journal":"Nature","n_participants":null,"pmid":"7651536","source_url":"https://pubmed.ncbi.nlm.nih.gov/7651536/","study_design":null,"title":"Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene","title_match":true,"year":1995},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/high-level-neuronal-expression-of-a142in-wild-type-human-amyloid-10818140","doi":"10.1523/jneurosci.20-11-04050.2000","journal":"Journal of Neuroscience","n_participants":null,"pmid":"10818140","source_url":"https://pubmed.ncbi.nlm.nih.gov/10818140/","study_design":null,"title":"High-Level Neuronal Expression of A\u03b21\u201342in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation","title_match":false,"year":2000},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/tardbp-mutations-in-individuals-with-sporadic-and-familial-18372902","doi":"10.1038/ng.132","journal":"Nature Genetics","n_participants":null,"pmid":"18372902","source_url":"https://pubmed.ncbi.nlm.nih.gov/18372902/","study_design":null,"title":"TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis","title_match":true,"year":2008},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/a-soluble-phosphorylated-tau-signature-links-tau-amyloid-and-the-32161412","doi":"10.1038/s41591-020-0781-z","journal":"Nature Medicine","n_participants":null,"pmid":"32161412","source_url":"https://pubmed.ncbi.nlm.nih.gov/32161412/","study_design":null,"title":"A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer\u2019s disease","title_match":true,"year":2020},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/mutations-in-the-fus-tls-gene-on-chromosome-16-cause-familial-19251627","doi":"10.1126/science.1166066","journal":"Science","n_participants":null,"pmid":"19251627","source_url":"https://pubmed.ncbi.nlm.nih.gov/19251627/","study_design":null,"title":"Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis","title_match":true,"year":2009},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/mutations-in-fus-an-rna-processing-protein-cause-familial-amyotrophic-19251628","doi":"10.1126/science.1165942","journal":"Science","n_participants":null,"pmid":"19251628","source_url":"https://pubmed.ncbi.nlm.nih.gov/19251628/","study_design":null,"title":"Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6","title_match":true,"year":2009},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-cholesterol-transport-protein-with-expanding-role-in-3283935","doi":"10.1126/science.3283935","journal":"Science","n_participants":null,"pmid":"3283935","source_url":"https://pubmed.ncbi.nlm.nih.gov/3283935/","study_design":null,"title":"Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology","title_match":false,"year":1988},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/consensus-report-of-the-working-group-on-molecular-and-biochemical-73d1d490","doi":"10.1016/s0197-4580(98)00022-0","journal":"Neurobiology of Aging","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/s0197-4580(98)00022-0","study_design":null,"title":"Consensus Report of the Working Group on: \u201cMolecular and Biochemical Markers of Alzheimer\u2019s Disease\u201d","title_match":false,"year":1998},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/clinical-and-biomarker-changes-of-alzheimer-s-disease-in-adults-with-32593336","doi":"10.1016/s0140-6736(20)30689-9","journal":"The Lancet","n_participants":null,"pmid":"32593336","source_url":"https://pubmed.ncbi.nlm.nih.gov/32593336/","study_design":null,"title":"Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study","title_match":false,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/mutation-of-the-amyloid-precursor-protein-in-familial-alzheimer-s-1465129","doi":"10.1038/360672a0","journal":"Nature","n_participants":null,"pmid":"1465129","source_url":"https://pubmed.ncbi.nlm.nih.gov/1465129/","study_design":null,"title":"Mutation of the \u03b2-amyloid precursor protein in familial Alzheimer's disease increases \u03b2-protein production","title_match":true,"year":1992},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/lewy-bodies-in-alzheimer-s-disease-a-neuropathological-review-of-145-10885656","doi":"10.1111/j.1750-3639.2000.tb00269.x","journal":"Brain Pathology","n_participants":null,"pmid":"10885656","source_url":"https://pubmed.ncbi.nlm.nih.gov/10885656/","study_design":null,"title":"Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using \u03b1\u2010Synuclein Immunohistochemistry","title_match":false,"year":2000},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-alzheimer-s-disease-a-review-and-proposal-for-the-21a895c8","doi":"10.1186/alzrt59","journal":"Alzheimer s Research & Therapy","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1186/alzrt59","study_design":null,"title":"Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/two-transmembrane-aspartates-in-presenilin-1-required-for-presenilin-10206644","doi":"10.1038/19077","journal":"Nature","n_participants":null,"pmid":"10206644","source_url":"https://pubmed.ncbi.nlm.nih.gov/10206644/","study_design":null,"title":"Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and \u03b3-secretase activity","title_match":true,"year":1999},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/an-increased-percentage-of-long-amyloid-protein-secreted-by-familial-8191290","doi":"10.1126/science.8191290","journal":"Science","n_participants":null,"pmid":"8191290","source_url":"https://pubmed.ncbi.nlm.nih.gov/8191290/","study_design":null,"title":"An Increased Percentage of Long Amyloid \u03b2 Protein Secreted by Familial Amyloid \u03b2 Protein Precursor (\u03b2App 717 ) Mutants","title_match":true,"year":1994},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/gantenerumab-reduces-brain-amyloid-proteoforms-biochemical-evaluation-09be60d1","doi":"10.64898/2026.09.22.26363432","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.22.26363432","study_design":null,"title":"Gantenerumab reduces brain amyloid-\u03b2 proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease","title_match":true,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/formation-and-function-of-apolipoprotein-e-containing-lipoproteins-in-20170744","doi":"10.1016/j.bbalip.2010.02.007","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"20170744","source_url":"https://pubmed.ncbi.nlm.nih.gov/20170744/","study_design":null,"title":"Formation and function of apolipoprotein E-containing lipoproteins in the nervous system","title_match":false,"year":2010},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/glucocerebrosidase-activity-modulates-neuronal-susceptibility-to-31899072","doi":"10.1016/j.neuron.2019.12.004","journal":"Neuron","n_participants":null,"pmid":"31899072","source_url":"https://pubmed.ncbi.nlm.nih.gov/31899072/","study_design":null,"title":"Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological \u03b1-Synuclein Insult","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/sustained-systemic-glucocerebrosidase-inhibition-induces-brain-26094487","doi":"10.1089/ars.2015.6307","journal":"Antioxidants & redox signaling","n_participants":null,"pmid":"26094487","source_url":"https://pubmed.ncbi.nlm.nih.gov/26094487/","study_design":null,"title":"Sustained Systemic Glucocerebrosidase Inhibition Induces Brain \u03b1-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/opposing-effects-of-viral-mediated-brain-expression-of-apolipoprotein-25871773","doi":"10.1186/s13024-015-0001-3","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"25871773","source_url":"https://pubmed.ncbi.nlm.nih.gov/25871773/","study_design":null,"title":"Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and A\u03b2 metabolism in apoE4-targeted replacement mice","title_match":false,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/translating-cell-biology-into-therapeutic-advances-in-alzheimer-s-10392577","doi":"10.1038/399a023","journal":"Nature","n_participants":null,"pmid":"10392577","source_url":"https://pubmed.ncbi.nlm.nih.gov/10392577/","study_design":null,"title":"Translating cell biology into therapeutic advances in Alzheimer's disease","title_match":false,"year":1999},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-three-dimensional-human-neural-cell-culture-model-of-alzheimer-s-25307057","doi":"10.1038/nature13800","journal":"Nature","n_participants":null,"pmid":"25307057","source_url":"https://pubmed.ncbi.nlm.nih.gov/25307057/","study_design":null,"title":"A three-dimensional human neural cell culture model of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/frontotemporal-dementia-in-the-netherlands-patient-characteristics-12876142","doi":"10.1093/brain/awg204","journal":"Brain : a journal of neurology","n_participants":74,"pmid":"12876142","source_url":"https://pubmed.ncbi.nlm.nih.gov/12876142/","study_design":null,"title":"Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/familial-multiple-system-tauopathy-with-presenile-dementia-a-disease-9108114","doi":"10.1073/pnas.94.8.4113","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9108114","source_url":"https://pubmed.ncbi.nlm.nih.gov/9108114/","study_design":null,"title":"Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments","title_match":true,"year":1997},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/trehalose-ameliorates-dopaminergic-and-tau-pathology-in-parkin-20546895","doi":"10.1016/j.nbd.2010.05.014","journal":"Neurobiology of disease","n_participants":null,"pmid":"20546895","source_url":"https://pubmed.ncbi.nlm.nih.gov/20546895/","study_design":null,"title":"Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/presenilins-are-essential-for-regulating-neurotransmitter-release-19641596","doi":"10.1038/nature08177","journal":"Nature","n_participants":null,"pmid":"19641596","source_url":"https://pubmed.ncbi.nlm.nih.gov/19641596/","study_design":null,"title":"Presenilins are essential for regulating neurotransmitter release","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/7-8-dihydroxyflavone-prevents-synaptic-loss-and-memory-deficits-in-a-24022672","doi":"10.1038/npp.2013.243","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":null,"pmid":"24022672","source_url":"https://pubmed.ncbi.nlm.nih.gov/24022672/","study_design":null,"title":"7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetic-modifiers-of-tauopathy-in-drosophila-14668378","doi":"10.1093/genetics/165.3.1233","journal":"Genetics","n_participants":null,"pmid":"14668378","source_url":"https://pubmed.ncbi.nlm.nih.gov/14668378/","study_design":null,"title":"Genetic modifiers of tauopathy in Drosophila","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-in-lewy-body-disease-and-alzheimer-s-disease-10517509","doi":"10.1111/j.1750-3639.1999.tb00552.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"10517509","source_url":"https://pubmed.ncbi.nlm.nih.gov/10517509/","study_design":null,"title":"Alpha-synuclein in Lewy body disease and Alzheimer's disease","title_match":false,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/prion-diseases-26633779","doi":"10.1212/con.0000000000000251","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"26633779","source_url":"https://pubmed.ncbi.nlm.nih.gov/26633779/","study_design":null,"title":"Prion Diseases","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/transgenic-mouse-model-of-tau-pathology-in-astrocytes-leading-to-15814784","doi":"10.1523/jneurosci.0081-05.2005","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"15814784","source_url":"https://pubmed.ncbi.nlm.nih.gov/15814784/","study_design":null,"title":"Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration","title_match":false,"year":2005},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-breakdown-in-alzheimer-s-disease-mechanisms-and-38003477","doi":"10.3390/ijms242216288","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38003477","source_url":"https://pubmed.ncbi.nlm.nih.gov/38003477/","study_design":null,"title":"Blood-Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies","title_match":false,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/synaptic-dysfunction-in-progranulin-deficient-mice-22062772","doi":"10.1016/j.nbd.2011.10.016","journal":"Neurobiology of disease","n_participants":null,"pmid":"22062772","source_url":"https://pubmed.ncbi.nlm.nih.gov/22062772/","study_design":null,"title":"Synaptic dysfunction in progranulin-deficient mice","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/tau-pathology-in-a-family-with-dementia-and-a-p301l-mutation-in-tau-10218629","doi":"10.1097/00005072-199904000-00004","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"10218629","source_url":"https://pubmed.ncbi.nlm.nih.gov/10218629/","study_design":null,"title":"Tau pathology in a family with dementia and a P301L mutation in tau","title_match":false,"year":1999},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/tau-gene-mutation-g389r-causes-a-tauopathy-with-abundant-pick-body-10604746","doi":"10.1097/00005072-199912000-00002","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"10604746","source_url":"https://pubmed.ncbi.nlm.nih.gov/10604746/","study_design":null,"title":"Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits","title_match":false,"year":1999},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-novel-presenilin-1-mutation-associated-with-pick-s-disease-but-not-15122701","doi":"10.1002/ana.20083","journal":"Annals of neurology","n_participants":null,"pmid":"15122701","source_url":"https://pubmed.ncbi.nlm.nih.gov/15122701/","study_design":null,"title":"A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques","title_match":true,"year":2004},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-synuclein-pathology-and-related-toxicity-32024798","doi":"10.1126/scitranslmed.aay1809","journal":"Science translational medicine","n_participants":null,"pmid":"32024798","source_url":"https://pubmed.ncbi.nlm.nih.gov/32024798/","study_design":null,"title":"APOE4 exacerbates \u03b1-synuclein pathology and related toxicity independent of amyloid","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/retarded-axonal-transport-of-r406w-mutant-tau-in-transgenic-mice-with-15140937","doi":"10.1523/jneurosci.0797-04.2004","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"15140937","source_url":"https://pubmed.ncbi.nlm.nih.gov/15140937/","study_design":null,"title":"Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy","title_match":false,"year":2004},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/c9orf72-deficiency-promotes-microglial-mediated-synaptic-loss-in-34133945","doi":"10.1016/j.neuron.2021.05.020","journal":"Neuron","n_participants":null,"pmid":"34133945","source_url":"https://pubmed.ncbi.nlm.nih.gov/34133945/","study_design":null,"title":"C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/new-old-pathologies-ad-part-and-cerebral-age-related-tdp-43-with-27209644","doi":"10.1093/jnen/nlw033","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"27209644","source_url":"https://pubmed.ncbi.nlm.nih.gov/27209644/","study_design":"longitudinal study","title":"\"New Old Pathologies\": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cdk5-is-involved-in-nft-like-tauopathy-induced-by-transient-cerebral-17113760","doi":"10.1016/j.bbadis.2006.10.011","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"17113760","source_url":"https://pubmed.ncbi.nlm.nih.gov/17113760/","study_design":null,"title":"Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats","title_match":false,"year":2007},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/klotho-overexpression-improves-amyloid-clearance-and-cognition-in-the-32964663","doi":"10.1111/acel.13239","journal":"Aging cell","n_participants":null,"pmid":"32964663","source_url":"https://pubmed.ncbi.nlm.nih.gov/32964663/","study_design":null,"title":"Klotho overexpression improves amyloid-\u03b2 clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-as-a-therapeutic-target-in-alzheimer-s-disease-a-27328687","doi":"10.1007/s40263-016-0361-4","journal":"CNS drugs","n_participants":null,"pmid":"27328687","source_url":"https://pubmed.ncbi.nlm.nih.gov/27328687/","study_design":null,"title":"Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence","title_match":false,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/transgenic-mouse-models-of-alzheimer-s-disease-an-integrative-analysis-35628216","doi":"10.3390/ijms23105404","journal":"International journal of molecular sciences","n_participants":null,"pmid":"35628216","source_url":"https://pubmed.ncbi.nlm.nih.gov/35628216/","study_design":null,"title":"Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/loss-of-function-chchd10-mutations-in-cytoplasmic-tdp-43-accumulation-28585542","doi":"10.1038/ncomms15558","journal":"Nature communications","n_participants":null,"pmid":"28585542","source_url":"https://pubmed.ncbi.nlm.nih.gov/28585542/","study_design":null,"title":"Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/spines-plasticity-and-cognition-in-alzheimer-s-model-mice-22203915","doi":"10.1155/2012/319836","journal":"Neural plasticity","n_participants":null,"pmid":"22203915","source_url":"https://pubmed.ncbi.nlm.nih.gov/22203915/","study_design":null,"title":"Spines, plasticity, and cognition in Alzheimer's model mice","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/corticostriatal-synaptic-function-in-mouse-models-of-huntington-s-17947312","doi":"10.1113/jphysiol.2007.142448","journal":"The Journal of physiology","n_participants":null,"pmid":"17947312","source_url":"https://pubmed.ncbi.nlm.nih.gov/17947312/","study_design":null,"title":"Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load","title_match":false,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/refining-frontotemporal-dementia-with-parkinsonism-linked-to-18413467","doi":"10.1001/archneur.65.4.460","journal":"Archives of neurology","n_participants":null,"pmid":"18413467","source_url":"https://pubmed.ncbi.nlm.nih.gov/18413467/","study_design":null,"title":"Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/creb-activity-and-nmnat2-transcription-are-down-regulated-prior-to-22027994","doi":"10.1093/hmg/ddr492","journal":"Human molecular genetics","n_participants":null,"pmid":"22027994","source_url":"https://pubmed.ncbi.nlm.nih.gov/22027994/","study_design":null,"title":"CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-distinct-familial-presenile-dementia-with-a-novel-missense-mutation-10208578","doi":"10.1097/00001756-199902250-00010","journal":"Neuroreport","n_participants":null,"pmid":"10208578","source_url":"https://pubmed.ncbi.nlm.nih.gov/10208578/","study_design":null,"title":"A distinct familial presenile dementia with a novel missense mutation in the tau gene","title_match":true,"year":1999},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/a-novel-prion-disease-associated-with-diarrhea-and-autonomic-24224623","doi":"10.1056/nejmoa1214747","journal":"The New England journal of medicine","n_participants":null,"pmid":"24224623","source_url":"https://pubmed.ncbi.nlm.nih.gov/24224623/","study_design":"longitudinal study","title":"A novel prion disease associated with diarrhea and autonomic neuropathy","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cell-mediated-neuroprotection-in-a-mouse-model-of-human-tauopathy-20668182","doi":"10.1523/jneurosci.0834-10.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"20668182","source_url":"https://pubmed.ncbi.nlm.nih.gov/20668182/","study_design":null,"title":"Cell-mediated neuroprotection in a mouse model of human tauopathy","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-mutation-at-codon-279-n279k-in-exon-10-of-the-tau-gene-causes-a-10412802","doi":"10.1007/s004010051052","journal":"Acta neuropathologica","n_participants":null,"pmid":"10412802","source_url":"https://pubmed.ncbi.nlm.nih.gov/10412802/","study_design":null,"title":"A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy","title_match":false,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetic-restoration-of-plasma-apoe-improves-cognition-and-partially-27683909","doi":"10.1523/jneurosci.1054-16.2016","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"27683909","source_url":"https://pubmed.ncbi.nlm.nih.gov/27683909/","study_design":null,"title":"Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/soluble-a-promotes-wild-type-tau-pathology-in-vivo-23197725","doi":"10.1523/jneurosci.0172-12.2012","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"23197725","source_url":"https://pubmed.ncbi.nlm.nih.gov/23197725/","study_design":null,"title":"Soluble a\u03b2 promotes wild-type tau pathology in vivo","title_match":false,"year":2012},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/enhanced-neurofibrillary-tangle-formation-cerebral-atrophy-and-16238489","doi":"10.1089/neu.2005.22.1134","journal":"Journal of neurotrauma","n_participants":18,"pmid":"16238489","source_url":"https://pubmed.ncbi.nlm.nih.gov/16238489/","study_design":null,"title":"Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model","title_match":false,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/reelin-protects-against-amyloid-toxicity-in-vivo-26152694","doi":"10.1126/scisignal.aaa6674","journal":"Science signaling","n_participants":null,"pmid":"26152694","source_url":"https://pubmed.ncbi.nlm.nih.gov/26152694/","study_design":null,"title":"Reelin protects against amyloid \u03b2 toxicity in vivo","title_match":false,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/prion-like-spreading-in-tauopathies-28506438","doi":"10.1016/j.biopsych.2017.04.003","journal":"Biological psychiatry","n_participants":null,"pmid":"28506438","source_url":"https://pubmed.ncbi.nlm.nih.gov/28506438/","study_design":null,"title":"Prion-like Spreading in Tauopathies","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-neuropathology-of-a-chromosome-17-linked-autosomal-dominant-9630238","doi":"10.1097/00005072-199806000-00006","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"9630238","source_url":"https://pubmed.ncbi.nlm.nih.gov/9630238/","study_design":null,"title":"The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia (\"pallido-ponto-nigral degeneration\")","title_match":true,"year":1998},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-and-alzheimer-s-disease-37834241","doi":"10.3390/ijms241914794","journal":"International journal of molecular sciences","n_participants":null,"pmid":"37834241","source_url":"https://pubmed.ncbi.nlm.nih.gov/37834241/","study_design":null,"title":"Amyloid Precursor Protein and Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-including-focal-presentations-30925614","doi":"10.1055/s-0039-1681041","journal":"Seminars in neurology","n_participants":null,"pmid":"30925614","source_url":"https://pubmed.ncbi.nlm.nih.gov/30925614/","study_design":null,"title":"Alzheimer's Disease Including Focal Presentations","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/tau-physiology-and-pathomechanisms-in-frontotemporal-lobar-27306859","doi":"10.1111/jnc.13600","journal":"Journal of neurochemistry","n_participants":null,"pmid":"27306859","source_url":"https://pubmed.ncbi.nlm.nih.gov/27306859/","study_design":null,"title":"Tau physiology and pathomechanisms in frontotemporal lobar degeneration","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/tau-is-required-for-progressive-synaptic-and-memory-deficits-in-a-31168644","doi":"10.1007/s00401-019-02032-w","journal":"Acta neuropathologica","n_participants":null,"pmid":"31168644","source_url":"https://pubmed.ncbi.nlm.nih.gov/31168644/","study_design":null,"title":"Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of \u03b1-synucleinopathy","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/bax-deletion-prevents-neuronal-loss-but-not-neurological-symptoms-in-15618403","doi":"10.1073/pnas.0406173102","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"15618403","source_url":"https://pubmed.ncbi.nlm.nih.gov/15618403/","study_design":null,"title":"Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease","title_match":true,"year":2005},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cxcr4-involvement-in-neurodegenerative-diseases-29636460","doi":"10.1038/s41398-017-0049-7","journal":"Translational psychiatry","n_participants":82337,"pmid":"29636460","source_url":"https://pubmed.ncbi.nlm.nih.gov/29636460/","study_design":null,"title":"CXCR4 involvement in neurodegenerative diseases","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/frequency-of-tau-mutations-in-three-series-of-non-alzheimer-s-10443890","doi":"10.1002/1531-8249(199908)46:2<243::aid-ana14>3.0.co;2-l","journal":"Annals of neurology","n_participants":null,"pmid":"10443890","source_url":"https://pubmed.ncbi.nlm.nih.gov/10443890/","study_design":null,"title":"Frequency of tau mutations in three series of non-Alzheimer's degenerative dementia","title_match":false,"year":1999},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/identification-of-conserved-proteomic-networks-in-neurodegenerative-32579933","doi":"10.1016/j.celrep.2020.107807","journal":"Cell reports","n_participants":null,"pmid":"32579933","source_url":"https://pubmed.ncbi.nlm.nih.gov/32579933/","study_design":null,"title":"Identification of Conserved Proteomic Networks in Neurodegenerative Dementia","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/age-dependent-axonal-transport-and-locomotor-changes-and-tau-21492964","doi":"10.1016/j.neurobiolaging.2011.02.014","journal":"Neurobiology of aging","n_participants":null,"pmid":"21492964","source_url":"https://pubmed.ncbi.nlm.nih.gov/21492964/","study_design":null,"title":"Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a \"P301L\" tau knockin mouse","title_match":false,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/calcium-dysregulation-contributes-to-neurodegeneration-in-ftld-27721502","doi":"10.1038/srep34904","journal":"Scientific reports","n_participants":null,"pmid":"27721502","source_url":"https://pubmed.ncbi.nlm.nih.gov/27721502/","study_design":null,"title":"Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/familial-amyotrophic-lateral-sclerosis-and-parkinsonism-dementia-11310628","doi":"10.1002/ana.100","journal":"Annals of neurology","n_participants":null,"pmid":"11310628","source_url":"https://pubmed.ncbi.nlm.nih.gov/11310628/","study_design":null,"title":"Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan: clinical and neuropathological study and tau analysis","title_match":true,"year":2001},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-als-pdc-syndrome-of-guam-and-the-cycad-hypothesis-18490618","doi":"10.1212/01.wnl.0000312571.81091.26","journal":"Neurology","n_participants":null,"pmid":"18490618","source_url":"https://pubmed.ncbi.nlm.nih.gov/18490618/","study_design":null,"title":"The ALS/PDC syndrome of Guam and the cycad hypothesis","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/tau-alternative-splicing-in-familial-and-sporadic-tauopathies-22817715","doi":"10.1042/bst20120091","journal":"Biochemical Society transactions","n_participants":null,"pmid":"22817715","source_url":"https://pubmed.ncbi.nlm.nih.gov/22817715/","study_design":null,"title":"Tau alternative splicing in familial and sporadic tauopathies","title_match":true,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/an-epigenetic-signature-in-peripheral-blood-associated-with-the-24603599","doi":"10.1371/journal.pgen.1004211","journal":"PLoS genetics","n_participants":null,"pmid":"24603599","source_url":"https://pubmed.ncbi.nlm.nih.gov/24603599/","study_design":null,"title":"An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy","title_match":false,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe2-gene-therapy-reduces-amyloid-deposition-and-improves-markers-of-38504517","doi":"10.1016/j.ymthe.2024.03.024","journal":"Molecular therapy : the journal of the American Society of Gene Therapy","n_participants":null,"pmid":"38504517","source_url":"https://pubmed.ncbi.nlm.nih.gov/38504517/","study_design":null,"title":"APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/consequences-of-metabolic-disruption-in-alzheimer-s-disease-pathology-31270743","doi":"10.1007/s13311-019-00755-y","journal":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","n_participants":null,"pmid":"31270743","source_url":"https://pubmed.ncbi.nlm.nih.gov/31270743/","study_design":null,"title":"Consequences of Metabolic Disruption in Alzheimer's Disease Pathology","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/integrative-system-biology-analyses-of-crispr-edited-ipsc-derived-30546007","doi":"10.1038/s41398-018-0319-z","journal":"Translational psychiatry","n_participants":null,"pmid":"30546007","source_url":"https://pubmed.ncbi.nlm.nih.gov/30546007/","study_design":null,"title":"Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/role-of-synucleins-in-alzheimer-s-disease-19551456","doi":"10.1007/s12640-009-9073-6","journal":"Neurotoxicity research","n_participants":null,"pmid":"19551456","source_url":"https://pubmed.ncbi.nlm.nih.gov/19551456/","study_design":null,"title":"Role of synucleins in Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genomic-architecture-of-human-17q21-linked-to-frontotemporal-dementia-15888485","doi":"10.1093/hmg/ddi182","journal":"Human molecular genetics","n_participants":17,"pmid":"15888485","source_url":"https://pubmed.ncbi.nlm.nih.gov/15888485/","study_design":null,"title":"Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region","title_match":false,"year":2005},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-in-parkinson-s-disease-epidemiology-clinical-34068064","doi":"10.3390/bs11050074","journal":"Behavioral sciences (Basel, Switzerland)","n_participants":null,"pmid":"34068064","source_url":"https://pubmed.ncbi.nlm.nih.gov/34068064/","study_design":null,"title":"Cognitive Impairment in Parkinson's Disease: Epidemiology, Clinical Profile, Protective and Risk Factors","title_match":false,"year":2021},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/virtual-reality-based-cognitive-motor-training-for-middle-aged-adults-29955655","doi":"10.1016/j.trci.2018.02.005","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":125,"pmid":"29955655","source_url":"https://pubmed.ncbi.nlm.nih.gov/29955655/","study_design":"randomized controlled trial","title":"Virtual reality-based cognitive-motor training for middle-aged adults at high Alzheimer's disease risk: A randomized controlled trial","title_match":false,"year":2018},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/non-genetic-risk-and-protective-factors-and-biomarkers-for-33435977","doi":"10.1186/s12916-020-01873-7","journal":"BMC medicine","n_participants":null,"pmid":"33435977","source_url":"https://pubmed.ncbi.nlm.nih.gov/33435977/","study_design":"meta-analysis","title":"Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews","title_match":true,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/adherence-to-mind-diet-genetic-susceptibility-and-incident-dementia-35807939","doi":"10.3390/nu14132759","journal":"Nutrients","n_participants":2449,"pmid":"35807939","source_url":"https://pubmed.ncbi.nlm.nih.gov/35807939/","study_design":null,"title":"Adherence to MIND Diet, Genetic Susceptibility, and Incident Dementia in Three US Cohorts","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/young-onset-parkinson-s-disease-revisited-clinical-features-natural-9827611","doi":"10.1002/mds.870130605","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":149,"pmid":"9827611","source_url":"https://pubmed.ncbi.nlm.nih.gov/9827611/","study_design":null,"title":"Young-onset Parkinson's disease revisited--clinical features, natural history, and mortality","title_match":false,"year":1998},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-pathological-basis-of-semantic-dementia-16000337","doi":"10.1093/brain/awh582","journal":"Brain : a journal of neurology","n_participants":13,"pmid":"16000337","source_url":"https://pubmed.ncbi.nlm.nih.gov/16000337/","study_design":null,"title":"The pathological basis of semantic dementia","title_match":false,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/pyroglutamate-formation-influences-solubility-and-amyloidogenicity-of-19518051","doi":"10.1021/bi900818a","journal":"Biochemistry","n_participants":null,"pmid":"19518051","source_url":"https://pubmed.ncbi.nlm.nih.gov/19518051/","study_design":null,"title":"Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mitochondriopathies-15009163","doi":"10.1046/j.1351-5101.2003.00728.x","journal":"European journal of neurology","n_participants":null,"pmid":"15009163","source_url":"https://pubmed.ncbi.nlm.nih.gov/15009163/","study_design":null,"title":"Mitochondriopathies","title_match":false,"year":2004},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-at-the-crossroads-of-alzheimer-s-disease-32096039","doi":"10.1007/978-981-32-9358-8_16","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"32096039","source_url":"https://pubmed.ncbi.nlm.nih.gov/32096039/","study_design":null,"title":"Amyloid-\u03b2 and Tau at the\u00a0Crossroads of Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/a-newly-uncovered-group-of-distantly-related-lysine-23349634","doi":"10.1371/journal.pgen.1003210","journal":"PLoS genetics","n_participants":null,"pmid":"23349634","source_url":"https://pubmed.ncbi.nlm.nih.gov/23349634/","study_design":null,"title":"A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity","title_match":false,"year":2013},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/niemann-pick-diseases-23622394","doi":"10.1016/b978-0-444-59565-2.00041-1","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"23622394","source_url":"https://pubmed.ncbi.nlm.nih.gov/23622394/","study_design":null,"title":"Niemann-Pick diseases","title_match":false,"year":2013},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/maternally-inherited-mitochondrial-myopathy-and-myoclonic-epilepsy-3922281","doi":"10.1002/ana.410170303","journal":"Annals of neurology","n_participants":null,"pmid":"3922281","source_url":"https://pubmed.ncbi.nlm.nih.gov/3922281/","study_design":null,"title":"Maternally inherited mitochondrial myopathy and myoclonic epilepsy","title_match":true,"year":1985},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/familial-amyotrophic-lateral-sclerosis-with-a-mutation-in-exon-4-of-8891072","doi":"10.1007/s004010050535","journal":"Acta neuropathologica","n_participants":null,"pmid":"8891072","source_url":"https://pubmed.ncbi.nlm.nih.gov/8891072/","study_design":null,"title":"Familial amyotrophic lateral sclerosis with a mutation in exon 4 of the Cu/Zn superoxide dismutase gene: pathological and immunocytochemical changes","title_match":true,"year":1996},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/development-of-disease-modifying-drugs-for-frontotemporal-dementia-32203398","doi":"10.1038/s41582-020-0330-x","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"32203398","source_url":"https://pubmed.ncbi.nlm.nih.gov/32203398/","study_design":null,"title":"Development of disease-modifying drugs for frontotemporal dementia spectrum disorders","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyotrophic-lateral-sclerosis-an-update-for-2013-clinical-features-24124634","doi":"10.14336/ad.2013.0400295","journal":"Aging and disease","n_participants":null,"pmid":"24124634","source_url":"https://pubmed.ncbi.nlm.nih.gov/24124634/","study_design":null,"title":"Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/effects-of-age-on-tissues-and-regions-of-the-cerebrum-and-cerebellum-11445259","doi":"10.1016/s0197-4580(01)00217-2","journal":"Neurobiology of aging","n_participants":null,"pmid":"11445259","source_url":"https://pubmed.ncbi.nlm.nih.gov/11445259/","study_design":null,"title":"Effects of age on tissues and regions of the cerebrum and cerebellum","title_match":false,"year":2001},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/identification-of-common-variants-associated-with-human-hippocampal-22504417","doi":"10.1038/ng.2250","journal":"Nature genetics","n_participants":21151,"pmid":"22504417","source_url":"https://pubmed.ncbi.nlm.nih.gov/22504417/","study_design":"meta-analysis","title":"Identification of common variants associated with human hippocampal and intracranial volumes","title_match":false,"year":2012},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/understanding-disease-progression-and-improving-alzheimer-s-disease-30321505","doi":"10.1016/j.jalz.2018.08.005","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"30321505","source_url":"https://pubmed.ncbi.nlm.nih.gov/30321505/","study_design":"longitudinal study","title":"Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/hippocampal-changes-associated-with-early-life-adversity-and-20015483","doi":"10.1016/j.biopsych.2009.10.017","journal":"Biological psychiatry","n_participants":null,"pmid":"20015483","source_url":"https://pubmed.ncbi.nlm.nih.gov/20015483/","study_design":"longitudinal study","title":"Hippocampal changes associated with early-life adversity and vulnerability to depression","title_match":false,"year":2010},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/association-of-disc1-trax-haplotypes-with-schizophrenia-reduced-16275808","doi":"10.1001/archpsyc.62.11.1205","journal":"Archives of general psychiatry","n_participants":null,"pmid":"16275808","source_url":"https://pubmed.ncbi.nlm.nih.gov/16275808/","study_design":"cohort study","title":"Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory","title_match":false,"year":2005},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/hippocampal-volumes-in-cognitively-normal-persons-at-genetic-risk-for-9708558","doi":"10.1002/ana.410440226","journal":"Annals of neurology","n_participants":22,"pmid":"9708558","source_url":"https://pubmed.ncbi.nlm.nih.gov/9708558/","study_design":null,"title":"Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease","title_match":true,"year":1998},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-apoe-genotype-has-dissociable-effects-on-memory-and-20479234","doi":"10.1073/pnas.1001412107","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":67,"pmid":"20479234","source_url":"https://pubmed.ncbi.nlm.nih.gov/20479234/","study_design":null,"title":"Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/magnetic-resonance-imaging-evidence-for-presymptomatic-change-in-23539189","doi":"10.1093/brain/awt065","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"23539189","source_url":"https://pubmed.ncbi.nlm.nih.gov/23539189/","study_design":null,"title":"Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/decreased-hippocampal-volume-in-healthy-girls-at-risk-of-depression-20194827","doi":"10.1001/archgenpsychiatry.2009.202","journal":"Archives of general psychiatry","n_participants":null,"pmid":"20194827","source_url":"https://pubmed.ncbi.nlm.nih.gov/20194827/","study_design":null,"title":"Decreased hippocampal volume in healthy girls at risk of depression","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/is-gray-matter-volume-an-intermediate-phenotype-for-schizophrenia-a-17689500","doi":"10.1016/j.biopsych.2007.05.027","journal":"Biological psychiatry","n_participants":169,"pmid":"17689500","source_url":"https://pubmed.ncbi.nlm.nih.gov/17689500/","study_design":null,"title":"Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/imaging-phenotypes-of-major-depressive-disorder-genetic-correlates-19358877","doi":"10.1016/j.neuroscience.2009.03.082","journal":"Neuroscience","n_participants":null,"pmid":"19358877","source_url":"https://pubmed.ncbi.nlm.nih.gov/19358877/","study_design":null,"title":"Imaging phenotypes of major depressive disorder: genetic correlates","title_match":false,"year":2009},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/contributions-of-genetic-risk-and-fetal-hypoxia-to-hippocampal-volume-12202271","doi":"10.1176/appi.ajp.159.9.1514","journal":"The American journal of psychiatry","n_participants":null,"pmid":"12202271","source_url":"https://pubmed.ncbi.nlm.nih.gov/12202271/","study_design":null,"title":"Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers","title_match":true,"year":2002},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/causal-associations-between-modifiable-risk-factors-and-the-alzheimer-32996171","doi":"10.1002/ana.25918","journal":"Annals of neurology","n_participants":null,"pmid":"32996171","source_url":"https://pubmed.ncbi.nlm.nih.gov/32996171/","study_design":null,"title":"Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-bdnf-val66met-polymorphism-impacts-parahippocampal-and-amygdala-19335934","doi":"10.1017/s0033291709005509","journal":"Psychological medicine","n_participants":null,"pmid":"19335934","source_url":"https://pubmed.ncbi.nlm.nih.gov/19335934/","study_design":null,"title":"The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression","title_match":true,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amygdala-and-hippocampal-volumes-in-familial-early-onset-major-17640621","doi":"10.1016/j.biopsych.2007.05.005","journal":"Biological psychiatry","n_participants":null,"pmid":"17640621","source_url":"https://pubmed.ncbi.nlm.nih.gov/17640621/","study_design":null,"title":"Amygdala and hippocampal volumes in familial early onset major depressive disorder","title_match":true,"year":2008},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/physical-activity-reduces-hippocampal-atrophy-in-elders-at-genetic-24795624","doi":"10.3389/fnagi.2014.00061","journal":"Frontiers in aging neuroscience","n_participants":24,"pmid":"24795624","source_url":"https://pubmed.ncbi.nlm.nih.gov/24795624/","study_design":"longitudinal study","title":"Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/heritability-of-brain-morphology-related-to-schizophrenia-a-large-17727823","doi":"10.1016/j.biopsych.2007.06.006","journal":"Biological psychiatry","n_participants":169,"pmid":"17727823","source_url":"https://pubmed.ncbi.nlm.nih.gov/17727823/","study_design":null,"title":"Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study","title_match":true,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/stress-abnormalities-in-individuals-at-risk-for-psychosis-a-review-of-22663896","doi":"10.1016/j.psyneuen.2012.05.003","journal":"Psychoneuroendocrinology","n_participants":null,"pmid":"22663896","source_url":"https://pubmed.ncbi.nlm.nih.gov/22663896/","study_design":null,"title":"Stress abnormalities in individuals at risk for psychosis: a review of studies in subjects with familial risk or with \"at risk\" mental state","title_match":true,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-ectodomain-of-the-notch3-receptor-accumulates-within-the-10712431","doi":"10.1172/jci8047","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"10712431","source_url":"https://pubmed.ncbi.nlm.nih.gov/10712431/","study_design":null,"title":"The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/role-of-superoxide-dismutases-in-oxidative-damage-and-12194501","doi":"10.1177/107385840200800408","journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","n_participants":null,"pmid":"12194501","source_url":"https://pubmed.ncbi.nlm.nih.gov/12194501/","study_design":null,"title":"Role of superoxide dismutases in oxidative damage and neurodegenerative disorders","title_match":false,"year":2002},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/patterns-of-mri-lesions-in-cadasil-9710018","doi":"10.1212/wnl.51.2.452","journal":"Neurology","n_participants":75,"pmid":"9710018","source_url":"https://pubmed.ncbi.nlm.nih.gov/9710018/","study_design":null,"title":"Patterns of MRI lesions in CADASIL","title_match":false,"year":1998},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/diagnostic-strategies-in-cadasil-12395806","doi":"10.1212/wnl.59.8.1134","journal":"Neurology","n_participants":null,"pmid":"12395806","source_url":"https://pubmed.ncbi.nlm.nih.gov/12395806/","study_design":null,"title":"Diagnostic strategies in CADASIL","title_match":false,"year":2002},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/genetic-correlates-of-brain-aging-on-mri-and-cognitive-test-measures-17903297","doi":"10.1186/1471-2350-8-s1-s15","journal":"BMC medical genetics","n_participants":705,"pmid":"17903297","source_url":"https://pubmed.ncbi.nlm.nih.gov/17903297/","study_design":null,"title":"Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study","title_match":false,"year":2007},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-leukoencephalopathy-and-subcortical-ischemic-8418535","doi":"10.1161/01.str.24.1.122","journal":"Stroke","n_participants":null,"pmid":"8418535","source_url":"https://pubmed.ncbi.nlm.nih.gov/8418535/","study_design":null,"title":"Autosomal dominant leukoencephalopathy and subcortical ischemic stroke. A clinicopathological study","title_match":true,"year":1993},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cadasil-a-common-form-of-hereditary-arteriopathy-causing-brain-12146805","doi":"10.1111/j.1750-3639.2002.tb00451.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"12146805","source_url":"https://pubmed.ncbi.nlm.nih.gov/12146805/","study_design":null,"title":"CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia","title_match":false,"year":2002},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-spectrum-of-cadasil-and-the-effect-of-cardiovascular-risk-20167921","doi":"10.1161/strokeaha.109.568402","journal":"Stroke","n_participants":null,"pmid":"20167921","source_url":"https://pubmed.ncbi.nlm.nih.gov/20167921/","study_design":"prospective cohort","title":"Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study in 200 consecutively recruited individuals","title_match":false,"year":2010},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-genetics-in-the-diagnosis-and-prediction-of-35383826","doi":"10.1093/brain/awac128","journal":"Brain : a journal of neurology","n_participants":1439,"pmid":"35383826","source_url":"https://pubmed.ncbi.nlm.nih.gov/35383826/","study_design":"case-control study","title":"Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-phospho-tau181-in-presymptomatic-and-symptomatic-familial-32665603","doi":"10.1038/s41380-020-0838-x","journal":"Molecular psychiatry","n_participants":70,"pmid":"32665603","source_url":"https://pubmed.ncbi.nlm.nih.gov/32665603/","study_design":"longitudinal study","title":"Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort study","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-p-tau231-p-tau181-pet-biomarkers-and-cognitive-change-in-older-35084051","doi":"10.1002/ana.26308","journal":"Annals of neurology","n_participants":129,"pmid":"35084051","source_url":"https://pubmed.ncbi.nlm.nih.gov/35084051/","study_design":null,"title":"Plasma p-tau231, p-tau181, PET Biomarkers, and Cognitive Change in Older Adults","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-predict-alzheimer-s-disease-before-clinical-onset-37875471","doi":"10.1038/s41467-023-42596-6","journal":"Nature communications","n_participants":126,"pmid":"37875471","source_url":"https://pubmed.ncbi.nlm.nih.gov/37875471/","study_design":null,"title":"Plasma biomarkers predict Alzheimer's disease before clinical onset in Chinese cohorts","title_match":false,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-lipid-homeostasis-in-the-etiology-and-treatment-24973118","doi":"10.1016/j.neurobiolaging.2014.03.037","journal":"Neurobiology of aging","n_participants":null,"pmid":"24973118","source_url":"https://pubmed.ncbi.nlm.nih.gov/24973118/","study_design":null,"title":"Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/ibuprofen-suppresses-plaque-pathology-and-inflammation-in-a-mouse-10908610","doi":"10.1523/jneurosci.20-15-05709.2000","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"10908610","source_url":"https://pubmed.ncbi.nlm.nih.gov/10908610/","study_design":null,"title":"Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease","title_match":false,"year":2000},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/a-trial-of-gantenerumab-or-solanezumab-in-dominantly-inherited-34155411","doi":"10.1038/s41591-021-01369-8","journal":"Nature medicine","n_participants":null,"pmid":"34155411","source_url":"https://pubmed.ncbi.nlm.nih.gov/34155411/","study_design":null,"title":"A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/attenuating-astrocyte-activation-accelerates-plaque-pathogenesis-in-23038755","doi":"10.1096/fj.12-208660","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"23038755","source_url":"https://pubmed.ncbi.nlm.nih.gov/23038755/","study_design":null,"title":"Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice","title_match":false,"year":2013},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/age-related-cognitive-deficits-impaired-long-term-potentiation-and-10188929","doi":"10.1016/s0306-4522(98)00410-2","journal":"Neuroscience","n_participants":15,"pmid":"10188929","source_url":"https://pubmed.ncbi.nlm.nih.gov/10188929/","study_design":"cross-sectional","title":"Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein","title_match":false,"year":1999},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neurofilament-proteins-as-biomarkers-to-monitor-neurological-diseases-34646114","doi":"10.3389/fnins.2021.689938","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"34646114","source_url":"https://pubmed.ncbi.nlm.nih.gov/34646114/","study_design":null,"title":"Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/a-fluid-biomarker-reveals-loss-of-tdp-43-splicing-repression-in-38278991","doi":"10.1038/s41591-023-02788-5","journal":"Nature medicine","n_participants":null,"pmid":"38278991","source_url":"https://pubmed.ncbi.nlm.nih.gov/38278991/","study_design":null,"title":"A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD","title_match":false,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neurofilament-protein-in-cerebrospinal-fluid-a-marker-of-white-matter-11746370","doi":"10.1002/jnr.1242","journal":"Journal of neuroscience research","n_participants":null,"pmid":"11746370","source_url":"https://pubmed.ncbi.nlm.nih.gov/11746370/","study_design":null,"title":"Neurofilament protein in cerebrospinal fluid: a marker of white matter changes","title_match":false,"year":2001},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/expression-of-app-pathway-mrnas-and-proteins-in-alzheimer-s-disease-17586478","doi":"10.1016/j.brainres.2007.05.050","journal":"Brain research","n_participants":null,"pmid":"17586478","source_url":"https://pubmed.ncbi.nlm.nih.gov/17586478/","study_design":null,"title":"Expression of APP pathway mRNAs and proteins in Alzheimer's disease","title_match":false,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mutant-presenilins-specifically-elevate-the-levels-of-the-42-residue-14645205","doi":"10.1093/hmg/ddh019","journal":"Human molecular genetics","n_participants":null,"pmid":"14645205","source_url":"https://pubmed.ncbi.nlm.nih.gov/14645205/","study_design":null,"title":"Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase","title_match":false,"year":2004},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/analysis-of-138-pathogenic-mutations-in-presenilin-1-on-the-in-vitro-27930341","doi":"10.1073/pnas.1618657114","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":138,"pmid":"27930341","source_url":"https://pubmed.ncbi.nlm.nih.gov/27930341/","study_design":null,"title":"Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of A\u03b242 and A\u03b240 peptides by \u03b3-secretase","title_match":true,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/structural-basis-for-increased-toxicity-of-pathological-a42-a40-22157754","doi":"10.1074/jbc.m111.264473","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"22157754","source_url":"https://pubmed.ncbi.nlm.nih.gov/22157754/","study_design":null,"title":"Structural basis for increased toxicity of pathological a\u03b242:a\u03b240 ratios in Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/presenilin-1-knockin-mice-reveal-loss-of-function-mechanism-for-25741723","doi":"10.1016/j.neuron.2015.02.010","journal":"Neuron","n_participants":null,"pmid":"25741723","source_url":"https://pubmed.ncbi.nlm.nih.gov/25741723/","study_design":null,"title":"Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease","title_match":true,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-monomers-transiently-sample-oligomer-and-fibril-like-configurations-23811057","doi":"10.1016/j.jmb.2013.06.021","journal":"Journal of molecular biology","n_participants":null,"pmid":"23811057","source_url":"https://pubmed.ncbi.nlm.nih.gov/23811057/","study_design":null,"title":"A\u03b2 monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/when-loss-is-gain-reduced-presenilin-proteolytic-function-leads-to-17268504","doi":"10.1038/sj.embor.7400896","journal":"EMBO reports","n_participants":null,"pmid":"17268504","source_url":"https://pubmed.ncbi.nlm.nih.gov/17268504/","study_design":null,"title":"When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease","title_match":true,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/characterization-and-molecular-profiling-of-psen1-familial-alzheimer-24416243","doi":"10.1371/journal.pone.0084547","journal":"PloS one","n_participants":null,"pmid":"24416243","source_url":"https://pubmed.ncbi.nlm.nih.gov/24416243/","study_design":null,"title":"Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors","title_match":true,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/glt-1-loss-accelerates-cognitive-deficit-onset-in-an-alzheimer-s-21677376","doi":"10.3233/jad-2011-110503","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21677376","source_url":"https://pubmed.ncbi.nlm.nih.gov/21677376/","study_design":null,"title":"GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/presenilin-2-familial-alzheimer-s-disease-mutations-result-in-partial-15663477","doi":"10.1111/j.1471-4159.2004.02858.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"15663477","source_url":"https://pubmed.ncbi.nlm.nih.gov/15663477/","study_design":null,"title":"Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios","title_match":true,"year":2005},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/amyloid-42-40-ratio-drives-tau-pathology-in-3d-human-neural-cell-32170138","doi":"10.1038/s41467-020-15120-3","journal":"Nature communications","n_participants":null,"pmid":"32170138","source_url":"https://pubmed.ncbi.nlm.nih.gov/32170138/","study_design":null,"title":"Amyloid-\u03b242/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/stem-cell-derived-basal-forebrain-cholinergic-neurons-from-alzheimer-24401693","doi":"10.1186/1750-1326-9-3","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"24401693","source_url":"https://pubmed.ncbi.nlm.nih.gov/24401693/","study_design":null,"title":"Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-presenilin-1-mutations-dramatically-reduce-trimming-of-long-25239621","doi":"10.1074/jbc.m114.581165","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"25239621","source_url":"https://pubmed.ncbi.nlm.nih.gov/25239621/","study_design":null,"title":"Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid \u03b2-peptides (A\u03b2) by \u03b3-secretase to increase 42-to-40-residue A\u03b2","title_match":true,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/crispr-cas9-correctable-mutation-related-molecular-and-physiological-29078805","doi":"10.1186/s40478-017-0475-z","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"29078805","source_url":"https://pubmed.ncbi.nlm.nih.gov/29078805/","study_design":null,"title":"CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons","title_match":true,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/extracellular-vesicle-associated-a-mediates-trans-neuronal-27928512","doi":"10.1038/npjamd.2016.19","journal":"NPJ aging and mechanisms of disease","n_participants":null,"pmid":"27928512","source_url":"https://pubmed.ncbi.nlm.nih.gov/27928512/","study_design":null,"title":"Extracellular Vesicle-Associated A\u03b2 Mediates Trans-Neuronal Bioenergetic and Ca 2+ -Handling Deficits in Alzheimer's Disease Models","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/activation-and-intrinsic-gamma-secretase-activity-of-presenilin-1-21115843","doi":"10.1073/pnas.1013246107","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"21115843","source_url":"https://pubmed.ncbi.nlm.nih.gov/21115843/","study_design":null,"title":"Activation and intrinsic gamma-secretase activity of presenilin 1","title_match":true,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-disease-patient-derived-neurons-reveal-distinct-30980041","doi":"10.1038/s41380-019-0410-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"30980041","source_url":"https://pubmed.ncbi.nlm.nih.gov/30980041/","study_design":null,"title":"Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/dissociation-between-the-processivity-and-total-activity-of-secretase-21919498","doi":"10.1021/bi2007146","journal":"Biochemistry","n_participants":null,"pmid":"21919498","source_url":"https://pubmed.ncbi.nlm.nih.gov/21919498/","study_design":null,"title":"Dissociation between the processivity and total activity of \u03b3-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations","title_match":true,"year":2011},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/genome-wide-haplotype-association-study-identifies-the-frmd4a-gene-as-22430674","doi":"10.1038/mp.2012.14","journal":"Molecular psychiatry","n_participants":2025,"pmid":"22430674","source_url":"https://pubmed.ncbi.nlm.nih.gov/22430674/","study_design":"case-control study","title":"Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-due-to-loss-of-function-a-new-synthesis-of-the-27327400","doi":"10.1016/j.pneurobio.2016.06.004","journal":"Progress in neurobiology","n_participants":null,"pmid":"27327400","source_url":"https://pubmed.ncbi.nlm.nih.gov/27327400/","study_design":null,"title":"Alzheimer's disease due to loss of function: A new synthesis of the available data","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/presenilin-1-l166p-mutant-human-pluripotent-stem-cell-derived-neurons-22510327","doi":"10.1016/j.ajpath.2012.02.012","journal":"The American journal of pathology","n_participants":null,"pmid":"22510327","source_url":"https://pubmed.ncbi.nlm.nih.gov/22510327/","study_design":null,"title":"Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of \u03b3-secretase activity in endogenous amyloid-\u03b2 generation","title_match":true,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/role-of-genes-linked-to-sporadic-alzheimer-s-disease-risk-in-the-22949636","doi":"10.1073/pnas.1201632109","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"22949636","source_url":"https://pubmed.ncbi.nlm.nih.gov/22949636/","study_design":null,"title":"Role of genes linked to sporadic Alzheimer's disease risk in the production of \u03b2-amyloid peptides","title_match":false,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/amyloid-beta-a-d7h-mutation-increases-oligomeric-a42-and-alters-22558227","doi":"10.1371/journal.pone.0035807","journal":"PloS one","n_participants":null,"pmid":"22558227","source_url":"https://pubmed.ncbi.nlm.nih.gov/22558227/","study_design":null,"title":"Amyloid-beta (A\u03b2) D7H mutation increases oligomeric A\u03b242 and alters properties of A\u03b2-zinc/copper assemblies","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cognitive-and-emotional-alterations-in-app-knock-in-mouse-models-of-a-30055565","doi":"10.1186/s12868-018-0446-8","journal":"BMC neuroscience","n_participants":null,"pmid":"30055565","source_url":"https://pubmed.ncbi.nlm.nih.gov/30055565/","study_design":null,"title":"Cognitive and emotional alterations in App knock-in mouse models of A\u03b2 amyloidosis","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/effect-of-potent-secretase-modulator-in-human-neurons-derived-from-25285942","doi":"10.1001/jamaneurol.2014.2482","journal":"JAMA neurology","n_participants":null,"pmid":"25285942","source_url":"https://pubmed.ncbi.nlm.nih.gov/25285942/","study_design":null,"title":"Effect of potent \u03b3-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers","title_match":true,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-mutations-within-apptm-increase-a42-production-24390130","doi":"10.1038/ncomms4037","journal":"Nature communications","n_participants":null,"pmid":"24390130","source_url":"https://pubmed.ncbi.nlm.nih.gov/24390130/","study_design":null,"title":"Familial Alzheimer's mutations within APPTM increase A\u03b242 production by enhancing accessibility of \u03b5-cleavage site","title_match":true,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-mutations-in-app-but-not-secretase-modulators-23907250","doi":"10.1038/ncomms3246","journal":"Nature communications","n_participants":null,"pmid":"23907250","source_url":"https://pubmed.ncbi.nlm.nih.gov/23907250/","study_design":null,"title":"Alzheimer's disease mutations in APP but not \u03b3-secretase modulators affect epsilon-cleavage-dependent AICD production","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mutations-in-the-transmembrane-domain-of-app-altering-gamma-secretase-9398269","doi":"10.1021/bi971071m","journal":"Biochemistry","n_participants":null,"pmid":"9398269","source_url":"https://pubmed.ncbi.nlm.nih.gov/9398269/","study_design":null,"title":"Mutations in the transmembrane domain of APP altering gamma-secretase specificity","title_match":false,"year":1997},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/dimerization-of-the-transmembrane-domain-of-amyloid-precursor-18234110","doi":"10.1186/1471-2202-9-17","journal":"BMC neuroscience","n_participants":null,"pmid":"18234110","source_url":"https://pubmed.ncbi.nlm.nih.gov/18234110/","study_design":null,"title":"Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants","title_match":true,"year":2008},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cathepsin-d-regulates-cerebral-a42-40-ratios-via-differential-32631408","doi":"10.1186/s13195-020-00649-8","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"32631408","source_url":"https://pubmed.ncbi.nlm.nih.gov/32631408/","study_design":null,"title":"Cathepsin D regulates cerebral A\u03b242/40 ratios via differential degradation of A\u03b242 and A\u03b240","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-disease-mutations-in-amyloid-protein-precursor-33450230","doi":"10.1016/j.jbc.2021.100281","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"33450230","source_url":"https://pubmed.ncbi.nlm.nih.gov/33450230/","study_design":null,"title":"Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by \u03b3-secretase to increase amyloid \u03b2-peptides of \u226545 residues","title_match":true,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/comparison-of-abeta-levels-in-the-brain-of-familial-and-sporadic-19524115","doi":"10.1016/j.neuint.2009.03.007","journal":"Neurochemistry international","n_participants":null,"pmid":"19524115","source_url":"https://pubmed.ncbi.nlm.nih.gov/19524115/","study_design":null,"title":"Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease","title_match":true,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/fad-mutants-unable-to-increase-neurotoxic-abeta-42-suggest-that-17254019","doi":"10.1111/j.1471-4159.2006.04391.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"17254019","source_url":"https://pubmed.ncbi.nlm.nih.gov/17254019/","study_design":null,"title":"FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta","title_match":false,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/contribution-of-genetic-and-dietary-insulin-resistance-to-alzheimer-21762376","doi":"10.1111/j.1582-4934.2011.01384.x","journal":"Journal of cellular and molecular medicine","n_participants":null,"pmid":"21762376","source_url":"https://pubmed.ncbi.nlm.nih.gov/21762376/","study_design":null,"title":"Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice","title_match":false,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-associated-mutations-increase-amyloid-precursor-27625790","doi":"10.1038/celldisc.2016.26","journal":"Cell discovery","n_participants":null,"pmid":"27625790","source_url":"https://pubmed.ncbi.nlm.nih.gov/27625790/","study_design":null,"title":"Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to \u03b3-secretase cleavage and the A\u03b242/A\u03b240 ratio","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/rapid-doubling-of-alzheimer-s-amyloid-40-and-42-levels-in-brains-of-24358824","doi":"10.12688/f1000research.1-70.v1","journal":"F1000Research","n_participants":null,"pmid":"24358824","source_url":"https://pubmed.ncbi.nlm.nih.gov/24358824/","study_design":null,"title":"Rapid doubling of Alzheimer's amyloid-\u03b240 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution","title_match":false,"year":2012},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/clinical-aspects-and-biomarkers-of-alzheimer-s-disease-in-down-28870521","doi":"10.1016/j.freeradbiomed.2017.08.024","journal":"Free radical biology & medicine","n_participants":null,"pmid":"28870521","source_url":"https://pubmed.ncbi.nlm.nih.gov/28870521/","study_design":null,"title":"Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome","title_match":false,"year":2018},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-psen1-p-e318g-variant-increases-the-risk-of-alzheimer-s-disease-23990795","doi":"10.1371/journal.pgen.1003685","journal":"PLoS genetics","n_participants":5161,"pmid":"23990795","source_url":"https://pubmed.ncbi.nlm.nih.gov/23990795/","study_design":"case-control study","title":"The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-\u03b54 carriers","title_match":true,"year":2013},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-cellular-complex-of-bace1-and-secretase-sequentially-generates-a-30626721","doi":"10.1083/jcb.201806205","journal":"The Journal of cell biology","n_participants":null,"pmid":"30626721","source_url":"https://pubmed.ncbi.nlm.nih.gov/30626721/","study_design":null,"title":"A cellular complex of BACE1 and \u03b3-secretase sequentially generates A\u03b2 from its full-length precursor","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/presenilin-1-adopts-pathogenic-conformation-in-normal-aging-and-in-23138650","doi":"10.1007/s00401-012-1065-6","journal":"Acta neuropathologica","n_participants":null,"pmid":"23138650","source_url":"https://pubmed.ncbi.nlm.nih.gov/23138650/","study_design":null,"title":"Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/riluzole-reduces-amyloid-beta-pathology-improves-memory-and-restores-30108205","doi":"10.1038/s41398-018-0201-z","journal":"Translational psychiatry","n_participants":null,"pmid":"30108205","source_url":"https://pubmed.ncbi.nlm.nih.gov/30108205/","study_design":null,"title":"Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/adhesion-molecule-l1-binds-to-amyloid-beta-and-reduces-alzheimer-s-23639788","doi":"10.1016/j.nbd.2013.04.014","journal":"Neurobiology of disease","n_participants":null,"pmid":"23639788","source_url":"https://pubmed.ncbi.nlm.nih.gov/23639788/","study_design":null,"title":"Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice","title_match":false,"year":2013},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-beta-measurements-a-desired-but-elusive-alzheimer-s-23470128","doi":"10.1186/alzrt162","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"23470128","source_url":"https://pubmed.ncbi.nlm.nih.gov/23470128/","study_design":"cross-sectional","title":"Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-in-autosomal-dominant-36576155","doi":"10.1002/alz.12879","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36576155","source_url":"https://pubmed.ncbi.nlm.nih.gov/36576155/","study_design":null,"title":"Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with A\u03b2-PET, neurodegeneration, and cognition","title_match":true,"year":2023},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/study-design-and-baseline-characteristics-of-a-population-based-33129280","doi":"10.1186/s12199-020-00903-3","journal":"Environmental health and preventive medicine","n_participants":11410,"pmid":"33129280","source_url":"https://pubmed.ncbi.nlm.nih.gov/33129280/","study_design":"cohort study","title":"Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)","title_match":false,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-profiles-in-autosomal-dominant-alzheimer-s-disease-36626935","doi":"10.1093/brain/awac399","journal":"Brain : a journal of neurology","n_participants":164,"pmid":"36626935","source_url":"https://pubmed.ncbi.nlm.nih.gov/36626935/","study_design":"longitudinal study","title":"Plasma biomarker profiles in autosomal dominant Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-involvement-of-lipids-in-alzheimer-s-disease-24894353","doi":"10.1016/j.jgg.2014.04.003","journal":"Journal of genetics and genomics = Yi chuan xue bao","n_participants":null,"pmid":"24894353","source_url":"https://pubmed.ncbi.nlm.nih.gov/24894353/","study_design":null,"title":"The involvement of lipids in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/alzheimer-s-polygenic-risk-scores-apoe-alzheimer-s-disease-risk-and-37516890","doi":"10.1186/s13195-023-01277-8","journal":"Alzheimer's research & therapy","n_participants":712,"pmid":"37516890","source_url":"https://pubmed.ncbi.nlm.nih.gov/37516890/","study_design":"cohort study","title":"Alzheimer's polygenic risk scores, APOE, Alzheimer's disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/large-scale-proteomic-analysis-of-alzheimer-s-disease-brain-and-32284590","doi":"10.1038/s41591-020-0815-6","journal":"Nature medicine","n_participants":null,"pmid":"32284590","source_url":"https://pubmed.ncbi.nlm.nih.gov/32284590/","study_design":null,"title":"Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/insulin-degrading-enzyme-regulates-extracellular-levels-of-amyloid-9830016","doi":"10.1074/jbc.273.49.32730","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"9830016","source_url":"https://pubmed.ncbi.nlm.nih.gov/9830016/","study_design":null,"title":"Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation","title_match":false,"year":1998},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/detection-of-oligomeric-forms-of-alpha-synuclein-protein-in-human-16507759","doi":"10.1096/fj.03-1449com","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"16507759","source_url":"https://pubmed.ncbi.nlm.nih.gov/16507759/","study_design":null,"title":"Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/disruption-of-the-sleep-wake-cycle-and-diurnal-fluctuation-of-amyloid-22956200","doi":"10.1126/scitranslmed.3004291","journal":"Science translational medicine","n_participants":null,"pmid":"22956200","source_url":"https://pubmed.ncbi.nlm.nih.gov/22956200/","study_design":null,"title":"Disruption of the sleep-wake cycle and diurnal fluctuation of \u03b2-amyloid in mice with Alzheimer's disease pathology","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/secretion-of-beta-amyloid-precursor-protein-cleaved-at-the-amino-7678698","doi":"10.1038/361260a0","journal":"Nature","n_participants":null,"pmid":"7678698","source_url":"https://pubmed.ncbi.nlm.nih.gov/7678698/","study_design":null,"title":"Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide","title_match":false,"year":1993},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-midlife-cognitive-profiles-of-adults-at-high-risk-of-late-onset-28365321","doi":"10.1016/j.jalz.2017.02.008","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":210,"pmid":"28365321","source_url":"https://pubmed.ncbi.nlm.nih.gov/28365321/","study_design":null,"title":"The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/relationships-between-hourly-cognitive-variability-and-risk-of-37079810","doi":"10.1037/neu0000905","journal":"Neuropsychology","n_participants":null,"pmid":"37079810","source_url":"https://pubmed.ncbi.nlm.nih.gov/37079810/","study_design":null,"title":"Relationships between hourly cognitive variability and risk of Alzheimer's disease revealed with mixed-effects location scale models","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/naturalistic-assessment-of-reaction-time-variability-in-older-adults-38282413","doi":"10.1017/s1355617723011475","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":null,"pmid":"38282413","source_url":"https://pubmed.ncbi.nlm.nih.gov/38282413/","study_design":null,"title":"Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/feasibility-and-acceptability-of-remote-smartphone-cognitive-testing-37180971","doi":"10.1002/dad2.12423","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":101,"pmid":"37180971","source_url":"https://pubmed.ncbi.nlm.nih.gov/37180971/","study_design":null,"title":"Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-polymorphism-and-alzheimer-s-disease-8103819","doi":"10.1016/0140-6736(93)91705-q","journal":"Lancet (London, England)","n_participants":91,"pmid":"8103819","source_url":"https://pubmed.ncbi.nlm.nih.gov/8103819/","study_design":null,"title":"Apolipoprotein E polymorphism and Alzheimer's disease","title_match":false,"year":1993},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/apoe-and-alzheimer-s-disease-advances-in-genetics-pathophysiology-and-33340485","doi":"10.1016/s1474-4422(20)30412-9","journal":"The Lancet. Neurology","n_participants":null,"pmid":"33340485","source_url":"https://pubmed.ncbi.nlm.nih.gov/33340485/","study_design":"meta-analysis","title":"APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe4-causes-widespread-molecular-and-cellular-alterations-associated-29861287","doi":"10.1016/j.neuron.2018.05.008","journal":"Neuron","n_participants":null,"pmid":"29861287","source_url":"https://pubmed.ncbi.nlm.nih.gov/29861287/","study_design":null,"title":"APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-major-risk-factors-for-alzheimer-s-disease-age-sex-and-genes-31018141","doi":"10.1016/j.celrep.2019.03.099","journal":"Cell reports","n_participants":null,"pmid":"31018141","source_url":"https://pubmed.ncbi.nlm.nih.gov/31018141/","study_design":null,"title":"The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to A\u03b2 Plaques","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/amyloid-accumulation-in-the-human-brain-after-one-night-of-sleep-29632177","doi":"10.1073/pnas.1721694115","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"29632177","source_url":"https://pubmed.ncbi.nlm.nih.gov/29632177/","study_design":null,"title":"\u03b2-Amyloid accumulation in the human brain after one night of sleep deprivation","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/chronic-traumatic-encephalopathy-in-a-national-football-league-player-15987548","doi":"10.1227/01.neu.0000163407.92769.ed","journal":"Neurosurgery","n_participants":null,"pmid":"15987548","source_url":"https://pubmed.ncbi.nlm.nih.gov/15987548/","study_design":null,"title":"Chronic traumatic encephalopathy in a National Football League player","title_match":false,"year":2005},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-the-cholesterol-connection-12658281","doi":"10.1038/nn0403-345","journal":"Nature neuroscience","n_participants":null,"pmid":"12658281","source_url":"https://pubmed.ncbi.nlm.nih.gov/12658281/","study_design":null,"title":"Alzheimer's disease: the cholesterol connection","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/calcium-and-neurodegeneration-17328689","doi":"10.1111/j.1474-9726.2007.00275.x","journal":"Aging cell","n_participants":null,"pmid":"17328689","source_url":"https://pubmed.ncbi.nlm.nih.gov/17328689/","study_design":null,"title":"Calcium and neurodegeneration","title_match":false,"year":2007},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe4-4-is-linked-to-damaging-lipid-droplets-in-alzheimer-s-disease-38480892","doi":"10.1038/s41586-024-07185-7","journal":"Nature","n_participants":null,"pmid":"38480892","source_url":"https://pubmed.ncbi.nlm.nih.gov/38480892/","study_design":null,"title":"APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia","title_match":false,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/accelerated-pericyte-degeneration-and-blood-brain-barrier-breakdown-25757756","doi":"10.1038/jcbfm.2015.44","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"25757756","source_url":"https://pubmed.ncbi.nlm.nih.gov/25757756/","study_design":null,"title":"Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/thirty-years-of-alzheimer-s-disease-genetics-the-implications-of-18802446","doi":"10.1038/nrn2494","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"18802446","source_url":"https://pubmed.ncbi.nlm.nih.gov/18802446/","study_design":"meta-analysis","title":"Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses","title_match":false,"year":2008},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cerebral-metabolic-and-cognitive-decline-in-persons-at-genetic-risk-10811879","doi":"10.1073/pnas.090106797","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10811879","source_url":"https://pubmed.ncbi.nlm.nih.gov/10811879/","study_design":"longitudinal study","title":"Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease","title_match":true,"year":2000},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/resistance-to-autosomal-dominant-alzheimer-s-disease-in-an-apoe3-31686034","doi":"10.1038/s41591-019-0611-3","journal":"Nature medicine","n_participants":null,"pmid":"31686034","source_url":"https://pubmed.ncbi.nlm.nih.gov/31686034/","study_design":null,"title":"Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report","title_match":true,"year":2019},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/meta-analysis-of-alzheimer-s-disease-risk-with-obesity-diabetes-and-19358976","doi":"10.1016/j.biopsych.2009.02.013","journal":"Biological psychiatry","n_participants":null,"pmid":"19358976","source_url":"https://pubmed.ncbi.nlm.nih.gov/19358976/","study_design":"meta-analysis","title":"Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders","title_match":false,"year":2010},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-independent-regulators-of-tau-pathology-in-alzheimer-disease-31780819","doi":"10.1038/s41583-019-0240-3","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"31780819","source_url":"https://pubmed.ncbi.nlm.nih.gov/31780819/","study_design":null,"title":"Amyloid-\u03b2-independent regulators of tau pathology in Alzheimer disease","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/a-quarter-century-of-apoe-and-alzheimer-s-disease-progress-to-date-30844401","doi":"10.1016/j.neuron.2019.01.056","journal":"Neuron","n_participants":null,"pmid":"30844401","source_url":"https://pubmed.ncbi.nlm.nih.gov/30844401/","study_design":null,"title":"A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe4-impairs-myelination-via-cholesterol-dysregulation-in-36385529","doi":"10.1038/s41586-022-05439-w","journal":"Nature","n_participants":null,"pmid":"36385529","source_url":"https://pubmed.ncbi.nlm.nih.gov/36385529/","study_design":null,"title":"APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/molecular-genetics-of-early-onset-alzheimer-s-disease-revisited-27016693","doi":"10.1016/j.jalz.2016.01.012","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"27016693","source_url":"https://pubmed.ncbi.nlm.nih.gov/27016693/","study_design":null,"title":"Molecular genetics of early-onset Alzheimer's disease revisited","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-alleles-as-risk-factors-in-alzheimer-s-disease-8712790","doi":"10.1146/annurev.med.47.1.387","journal":"Annual review of medicine","n_participants":null,"pmid":"8712790","source_url":"https://pubmed.ncbi.nlm.nih.gov/8712790/","study_design":null,"title":"Apolipoprotein E alleles as risk factors in Alzheimer's disease","title_match":false,"year":1996},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe2-apoe3-and-apoe4-differentially-stimulate-app-transcription-and-28111074","doi":"10.1016/j.cell.2016.12.044","journal":"Cell","n_participants":null,"pmid":"28111074","source_url":"https://pubmed.ncbi.nlm.nih.gov/28111074/","study_design":null,"title":"ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A\u03b2 Secretion","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-in-animal-models-of-cns-injury-and-in-alzheimer-s-7532337","doi":"10.1016/0166-2236(94)90156-2","journal":"Trends in neurosciences","n_participants":null,"pmid":"7532337","source_url":"https://pubmed.ncbi.nlm.nih.gov/7532337/","study_design":null,"title":"Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease","title_match":false,"year":1994},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-structure-determines-function-from-atherosclerosis-19106071","doi":"10.1194/jlr.r800069-jlr200","journal":"Journal of lipid research","n_participants":null,"pmid":"19106071","source_url":"https://pubmed.ncbi.nlm.nih.gov/19106071/","study_design":null,"title":"Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS","title_match":false,"year":2009},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/genome-wide-association-meta-analysis-in-269-867-individuals-29942086","doi":"10.1038/s41588-018-0152-6","journal":"Nature genetics","n_participants":269867,"pmid":"29942086","source_url":"https://pubmed.ncbi.nlm.nih.gov/29942086/","study_design":"meta-analysis","title":"Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/haploinsufficiency-of-tbk1-causes-familial-als-and-fronto-temporal-25803835","doi":"10.1038/nn.4000","journal":"Nature neuroscience","n_participants":null,"pmid":"25803835","source_url":"https://pubmed.ncbi.nlm.nih.gov/25803835/","study_design":null,"title":"Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia","title_match":true,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/towards-clinical-utility-of-polygenic-risk-scores-31363735","doi":"10.1093/hmg/ddz187","journal":"Human molecular genetics","n_participants":null,"pmid":"31363735","source_url":"https://pubmed.ncbi.nlm.nih.gov/31363735/","study_design":null,"title":"Towards clinical utility of polygenic risk scores","title_match":true,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/genome-wide-association-analysis-reveals-putative-alzheimer-s-disease-18976728","doi":"10.1016/j.ajhg.2008.10.008","journal":"American journal of human genetics","n_participants":2700,"pmid":"18976728","source_url":"https://pubmed.ncbi.nlm.nih.gov/18976728/","study_design":null,"title":"Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE","title_match":false,"year":2008},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-high-density-whole-genome-association-study-reveals-that-apoe-is-17474819","doi":"10.4088/jcp.v68n0419","journal":"The Journal of clinical psychiatry","n_participants":null,"pmid":"17474819","source_url":"https://pubmed.ncbi.nlm.nih.gov/17474819/","study_design":null,"title":"A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease","title_match":false,"year":2007},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-multiplex-model-of-the-genetics-of-alzheimer-s-disease-32112059","doi":"10.1038/s41593-020-0599-5","journal":"Nature neuroscience","n_participants":null,"pmid":"32112059","source_url":"https://pubmed.ncbi.nlm.nih.gov/32112059/","study_design":null,"title":"The multiplex model of the genetics of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/single-cell-epigenomic-analyses-implicate-candidate-causal-variants-33106633","doi":"10.1038/s41588-020-00721-x","journal":"Nature genetics","n_participants":null,"pmid":"33106633","source_url":"https://pubmed.ncbi.nlm.nih.gov/33106633/","study_design":null,"title":"Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases","title_match":true,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/common-polygenic-variation-enhances-risk-prediction-for-alzheimer-s-26490334","doi":"10.1093/brain/awv268","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"26490334","source_url":"https://pubmed.ncbi.nlm.nih.gov/26490334/","study_design":null,"title":"Common polygenic variation enhances risk prediction for Alzheimer's disease","title_match":true,"year":2015},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-habitual-physical-activity-in-over-29899525","doi":"10.1038/s41366-018-0120-3","journal":"International journal of obesity (2005)","n_participants":8556,"pmid":"29899525","source_url":"https://pubmed.ncbi.nlm.nih.gov/29899525/","study_design":"meta-analysis","title":"Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE","title_match":false,"year":2018},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/common-variants-in-alzheimer-s-disease-and-risk-stratification-by-34099642","doi":"10.1038/s41467-021-22491-8","journal":"Nature communications","n_participants":409435,"pmid":"34099642","source_url":"https://pubmed.ncbi.nlm.nih.gov/34099642/","study_design":"case-control study","title":"Common variants in Alzheimer's disease and risk stratification by polygenic risk scores","title_match":true,"year":2021},{"alzhub_score":86,"alzhub_url":"https://alzhub.org/study/genetic-contributions-to-variation-in-general-cognitive-function-a-25644384","doi":"10.1038/mp.2014.188","journal":"Molecular psychiatry","n_participants":53949,"pmid":"25644384","source_url":"https://pubmed.ncbi.nlm.nih.gov/25644384/","study_design":"meta-analysis","title":"Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949)","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-cognitive-functions-and-educational-27046643","doi":"10.1038/mp.2016.45","journal":"Molecular psychiatry","n_participants":36,"pmid":"27046643","source_url":"https://pubmed.ncbi.nlm.nih.gov/27046643/","study_design":null,"title":"Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)","title_match":false,"year":2016},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/shared-genetic-aetiology-between-cognitive-functions-and-physical-and-26809841","doi":"10.1038/mp.2015.225","journal":"Molecular psychiatry","n_participants":112,"pmid":"26809841","source_url":"https://pubmed.ncbi.nlm.nih.gov/26809841/","study_design":null,"title":"Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/hippocampal-atrophy-as-a-quantitative-trait-in-a-genome-wide-19668339","doi":"10.1371/journal.pone.0006501","journal":"PloS one","n_participants":381,"pmid":"19668339","source_url":"https://pubmed.ncbi.nlm.nih.gov/19668339/","study_design":"case-control study","title":"Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/expansion-of-human-specific-ggc-repeat-in-neuronal-intranuclear-31178126","doi":"10.1016/j.ajhg.2019.05.013","journal":"American journal of human genetics","n_participants":null,"pmid":"31178126","source_url":"https://pubmed.ncbi.nlm.nih.gov/31178126/","study_design":null,"title":"Expansion of Human-Specific GGC Repeat in Neuronal Intranuclear Inclusion Disease-Related Disorders","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-an-updated-overview-of-its-genetics-36835161","doi":"10.3390/ijms24043754","journal":"International journal of molecular sciences","n_participants":null,"pmid":"36835161","source_url":"https://pubmed.ncbi.nlm.nih.gov/36835161/","study_design":null,"title":"Alzheimer's Disease: An Updated Overview of Its Genetics","title_match":false,"year":2023},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/case-control-association-mapping-by-proxy-using-family-history-of-28092683","doi":"10.1038/ng.3766","journal":"Nature genetics","n_participants":116196,"pmid":"28092683","source_url":"https://pubmed.ncbi.nlm.nih.gov/28092683/","study_design":"meta-analysis","title":"Case-control association mapping by proxy using family history of disease","title_match":true,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-analyzing-the-missing-heritability-24244562","doi":"10.1371/journal.pone.0079771","journal":"PloS one","n_participants":10922,"pmid":"24244562","source_url":"https://pubmed.ncbi.nlm.nih.gov/24244562/","study_design":null,"title":"Alzheimer's disease: analyzing the missing heritability","title_match":true,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/picalm-modulates-autophagy-activity-and-tau-accumulation-25241929","doi":"10.1038/ncomms5998","journal":"Nature communications","n_participants":null,"pmid":"25241929","source_url":"https://pubmed.ncbi.nlm.nih.gov/25241929/","study_design":null,"title":"PICALM modulates autophagy activity and tau accumulation","title_match":false,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/genomics-of-1-million-parent-lifespans-implicates-novel-pathways-and-30642433","doi":"10.7554/elife.39856","journal":"eLife","n_participants":null,"pmid":"30642433","source_url":"https://pubmed.ncbi.nlm.nih.gov/30642433/","study_design":null,"title":"Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances","title_match":false,"year":2019},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/genetic-modifiers-of-risk-and-age-at-onset-in-gba-associated-31755958","doi":"10.1093/brain/awz350","journal":"Brain : a journal of neurology","n_participants":165,"pmid":"31755958","source_url":"https://pubmed.ncbi.nlm.nih.gov/31755958/","study_design":"case-control study","title":"Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia","title_match":false,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-identifies-four-novel-loci-associated-28247064","doi":"10.1007/s00401-017-1685-y","journal":"Acta neuropathologica","n_participants":3146,"pmid":"28247064","source_url":"https://pubmed.ncbi.nlm.nih.gov/28247064/","study_design":"case-control study","title":"Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers","title_match":false,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/identifying-individuals-with-high-risk-of-alzheimer-s-disease-using-34301930","doi":"10.1038/s41467-021-24082-z","journal":"Nature communications","n_participants":null,"pmid":"34301930","source_url":"https://pubmed.ncbi.nlm.nih.gov/34301930/","study_design":null,"title":"Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores","title_match":true,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/voxelwise-genome-wide-association-study-vgwas-20171287","doi":"10.1016/j.neuroimage.2010.02.032","journal":"NeuroImage","n_participants":null,"pmid":"20171287","source_url":"https://pubmed.ncbi.nlm.nih.gov/20171287/","study_design":null,"title":"Voxelwise genome-wide association study (vGWAS)","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-genetic-architecture-of-alzheimer-s-disease-beyond-app-psens-and-20594621","doi":"10.1016/j.neurobiolaging.2010.03.025","journal":"Neurobiology of aging","n_participants":null,"pmid":"20594621","source_url":"https://pubmed.ncbi.nlm.nih.gov/20594621/","study_design":null,"title":"The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/chromosome-9p21-in-amyotrophic-lateral-sclerosis-in-finland-a-genome-20801718","doi":"10.1016/s1474-4422(10)70184-8","journal":"The Lancet. Neurology","n_participants":40,"pmid":"20801718","source_url":"https://pubmed.ncbi.nlm.nih.gov/20801718/","study_design":null,"title":"Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-genome-wide-scan-for-common-variants-affecting-the-rate-of-age-22054870","doi":"10.1016/j.neurobiolaging.2011.09.033","journal":"Neurobiology of aging","n_participants":749,"pmid":"22054870","source_url":"https://pubmed.ncbi.nlm.nih.gov/22054870/","study_design":null,"title":"A genome-wide scan for common variants affecting the rate of age-related cognitive decline","title_match":false,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-apoe-levels-an-endophenotype-for-genetic-studies-22821396","doi":"10.1093/hmg/dds296","journal":"Human molecular genetics","n_participants":641,"pmid":"22821396","source_url":"https://pubmed.ncbi.nlm.nih.gov/22821396/","study_design":null,"title":"Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/integrating-the-environmental-and-genetic-architectures-of-aging-and-39972219","doi":"10.1038/s41591-024-03483-9","journal":"Nature medicine","n_participants":492567,"pmid":"39972219","source_url":"https://pubmed.ncbi.nlm.nih.gov/39972219/","study_design":null,"title":"Integrating the environmental and genetic architectures of aging and mortality","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/common-genetic-variants-associated-with-cognitive-performance-25201988","doi":"10.1073/pnas.1404623111","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":106736,"pmid":"25201988","source_url":"https://pubmed.ncbi.nlm.nih.gov/25201988/","study_design":null,"title":"Common genetic variants associated with cognitive performance identified using the proxy-phenotype method","title_match":false,"year":2014},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/human-longevity-25-genetic-loci-associated-in-389-166-uk-biobank-29227965","doi":"10.18632/aging.101334","journal":"Aging","n_participants":1181,"pmid":"29227965","source_url":"https://pubmed.ncbi.nlm.nih.gov/29227965/","study_design":"longitudinal study","title":"Human longevity: 25 genetic loci associated in 389,166 UK biobank participants","title_match":false,"year":2017},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-role-of-abca7-in-alzheimer-s-disease-evidence-from-genomics-30903345","doi":"10.1007/s00401-019-01994-1","journal":"Acta neuropathologica","n_participants":null,"pmid":"30903345","source_url":"https://pubmed.ncbi.nlm.nih.gov/30903345/","study_design":null,"title":"The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/estimation-and-partitioning-of-polygenic-variation-captured-by-common-23193196","doi":"10.1093/hmg/dds491","journal":"Human molecular genetics","n_participants":null,"pmid":"23193196","source_url":"https://pubmed.ncbi.nlm.nih.gov/23193196/","study_design":null,"title":"Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis","title_match":true,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetics-of-familial-and-sporadic-alzheimer-s-disease-23276979","doi":"10.2741/e605","journal":"Frontiers in bioscience (Elite edition)","n_participants":null,"pmid":"23276979","source_url":"https://pubmed.ncbi.nlm.nih.gov/23276979/","study_design":null,"title":"Genetics of familial and sporadic Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/untangling-genetic-risk-for-alzheimer-s-disease-28666525","doi":"10.1016/j.biopsych.2017.05.014","journal":"Biological psychiatry","n_participants":null,"pmid":"28666525","source_url":"https://pubmed.ncbi.nlm.nih.gov/28666525/","study_design":null,"title":"Untangling Genetic Risk for Alzheimer's Disease","title_match":true,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/ccnf-mutations-in-amyotrophic-lateral-sclerosis-and-frontotemporal-27080313","doi":"10.1038/ncomms11253","journal":"Nature communications","n_participants":null,"pmid":"27080313","source_url":"https://pubmed.ncbi.nlm.nih.gov/27080313/","study_design":null,"title":"CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/convergent-genetic-and-expression-data-implicate-immunity-in-25533204","doi":"10.1016/j.jalz.2014.05.1757","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"25533204","source_url":"https://pubmed.ncbi.nlm.nih.gov/25533204/","study_design":null,"title":"Convergent genetic and expression data implicate immunity in Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/chromosome-9p21-in-sporadic-amyotrophic-lateral-sclerosis-in-the-uk-20801717","doi":"10.1016/s1474-4422(10)70197-6","journal":"The Lancet. Neurology","n_participants":599,"pmid":"20801717","source_url":"https://pubmed.ncbi.nlm.nih.gov/20801717/","study_design":null,"title":"Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study","title_match":false,"year":2010},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/genome-wide-association-for-major-depression-through-age-at-onset-27519822","doi":"10.1016/j.biopsych.2016.05.010","journal":"Biological psychiatry","n_participants":null,"pmid":"27519822","source_url":"https://pubmed.ncbi.nlm.nih.gov/27519822/","study_design":"meta-analysis","title":"Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/epidemiology-and-etiology-of-alzheimer-s-disease-from-genetic-to-non-23919770","doi":"10.2174/15672050113109990155","journal":"Current Alzheimer research","n_participants":null,"pmid":"23919770","source_url":"https://pubmed.ncbi.nlm.nih.gov/23919770/","study_design":null,"title":"Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors","title_match":false,"year":2013},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/genomic-variants-genes-and-pathways-of-alzheimer-s-disease-an-overview-27943641","doi":"10.1002/ajmg.b.32499","journal":"American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics","n_participants":null,"pmid":"27943641","source_url":"https://pubmed.ncbi.nlm.nih.gov/27943641/","study_design":null,"title":"Genomic variants, genes, and pathways of Alzheimer's disease: An overview","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/psychosis-in-alzheimer-s-disease-24103379","doi":"10.1016/j.biopsych.2013.08.020","journal":"Biological psychiatry","n_participants":null,"pmid":"24103379","source_url":"https://pubmed.ncbi.nlm.nih.gov/24103379/","study_design":null,"title":"Psychosis in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-brain-structure-and-genetic-mechanisms-underlying-the-nonlinear-37118065","doi":"10.1038/s43587-022-00210-2","journal":"Nature aging","n_participants":null,"pmid":"37118065","source_url":"https://pubmed.ncbi.nlm.nih.gov/37118065/","study_design":"longitudinal study","title":"The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health","title_match":false,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/iron-accumulation-in-microglia-triggers-a-cascade-of-events-that-30661261","doi":"10.1111/bpa.12704","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"30661261","source_url":"https://pubmed.ncbi.nlm.nih.gov/30661261/","study_design":null,"title":"Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-vast-complexity-of-primary-open-angle-glaucoma-disease-genes-24055863","doi":"10.1016/j.preteyeres.2013.09.001","journal":"Progress in retinal and eye research","n_participants":null,"pmid":"24055863","source_url":"https://pubmed.ncbi.nlm.nih.gov/24055863/","study_design":null,"title":"The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology","title_match":false,"year":2013},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-multiomics-approach-to-heterogeneity-in-alzheimer-s-disease-focused-31891371","doi":"10.1093/brain/awz384","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"31891371","source_url":"https://pubmed.ncbi.nlm.nih.gov/31891371/","study_design":null,"title":"A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/risk-prediction-of-late-onset-alzheimer-s-disease-implies-an-32968074","doi":"10.1038/s41467-020-18534-1","journal":"Nature communications","n_participants":null,"pmid":"32968074","source_url":"https://pubmed.ncbi.nlm.nih.gov/32968074/","study_design":null,"title":"Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-presenilin-1-dependent-gamma-secretase-like-protease-mediates-10206645","doi":"10.1038/19083","journal":"Nature","n_participants":null,"pmid":"10206645","source_url":"https://pubmed.ncbi.nlm.nih.gov/10206645/","study_design":null,"title":"A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain","title_match":true,"year":1999},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/deficiency-of-presenilin-1-inhibits-the-normal-cleavage-of-amyloid-9450754","doi":"10.1038/34910","journal":"Nature","n_participants":null,"pmid":"9450754","source_url":"https://pubmed.ncbi.nlm.nih.gov/9450754/","study_design":null,"title":"Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein","title_match":true,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-multifaceted-roles-of-glycogen-synthase-kinase-3beta-in-cellular-11527574","doi":"10.1016/s0301-0082(01)00011-9","journal":"Progress in neurobiology","n_participants":null,"pmid":"11527574","source_url":"https://pubmed.ncbi.nlm.nih.gov/11527574/","study_design":null,"title":"The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling","title_match":false,"year":2001},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-disease-linked-presenilin-1-variants-elevate-8938131","doi":"10.1016/s0896-6273(00)80230-5","journal":"Neuron","n_participants":null,"pmid":"8938131","source_url":"https://pubmed.ncbi.nlm.nih.gov/8938131/","study_design":null,"title":"Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo","title_match":true,"year":1996},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/increased-amyloid-beta42-43-in-brains-of-mice-expressing-mutant-8878479","doi":"10.1038/383710a0","journal":"Nature","n_participants":null,"pmid":"8878479","source_url":"https://pubmed.ncbi.nlm.nih.gov/8878479/","study_design":null,"title":"Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1","title_match":true,"year":1996},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/lysosomal-proteolysis-and-autophagy-require-presenilin-1-and-are-20541250","doi":"10.1016/j.cell.2010.05.008","journal":"Cell","n_participants":null,"pmid":"20541250","source_url":"https://pubmed.ncbi.nlm.nih.gov/20541250/","study_design":null,"title":"Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations","title_match":true,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-the-presenilins-and-alzheimer-s-disease-9106355","doi":"10.1016/s0166-2236(96)01030-2","journal":"Trends in neurosciences","n_participants":null,"pmid":"9106355","source_url":"https://pubmed.ncbi.nlm.nih.gov/9106355/","study_design":null,"title":"Amyloid, the presenilins and Alzheimer's disease","title_match":false,"year":1997},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/gsk-3alpha-regulates-production-of-alzheimer-s-disease-amyloid-beta-12761548","doi":"10.1038/nature01640","journal":"Nature","n_participants":null,"pmid":"12761548","source_url":"https://pubmed.ncbi.nlm.nih.gov/12761548/","study_design":null,"title":"GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides","title_match":false,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/mutant-presenilins-of-alzheimer-s-disease-increase-production-of-42-8986743","doi":"10.1038/nm0197-67","journal":"Nature medicine","n_participants":null,"pmid":"8986743","source_url":"https://pubmed.ncbi.nlm.nih.gov/8986743/","study_design":null,"title":"Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice","title_match":false,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/plaque-independent-disruption-of-neural-circuits-in-alzheimer-s-10077666","doi":"10.1073/pnas.96.6.3228","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10077666","source_url":"https://pubmed.ncbi.nlm.nih.gov/10077666/","study_design":null,"title":"Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models","title_match":false,"year":1999},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-arctic-app-mutation-e693g-causes-alzheimer-s-disease-by-enhanced-11528419","doi":"10.1038/nn0901-887","journal":"Nature neuroscience","n_participants":null,"pmid":"11528419","source_url":"https://pubmed.ncbi.nlm.nih.gov/11528419/","study_design":null,"title":"The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation","title_match":true,"year":2001},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/microglia-derived-asc-specks-cross-seed-amyloid-in-alzheimer-s-disease-29293211","doi":"10.1038/nature25158","journal":"Nature","n_participants":null,"pmid":"29293211","source_url":"https://pubmed.ncbi.nlm.nih.gov/29293211/","study_design":null,"title":"Microglia-derived ASC specks cross-seed amyloid-\u03b2 in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/early-onset-alzheimer-s-disease-caused-by-mutations-at-codon-717-of-1944558","doi":"10.1038/353844a0","journal":"Nature","n_participants":null,"pmid":"1944558","source_url":"https://pubmed.ncbi.nlm.nih.gov/1944558/","study_design":null,"title":"Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene","title_match":false,"year":1991},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/macroautophagy-a-novel-beta-amyloid-peptide-generating-pathway-16203860","doi":"10.1083/jcb.200505082","journal":"The Journal of cell biology","n_participants":null,"pmid":"16203860","source_url":"https://pubmed.ncbi.nlm.nih.gov/16203860/","study_design":null,"title":"Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease","title_match":false,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/intraneuronal-abeta42-accumulation-in-human-brain-10623648","doi":"10.1016/s0002-9440(10)64700-1","journal":"The American journal of pathology","n_participants":null,"pmid":"10623648","source_url":"https://pubmed.ncbi.nlm.nih.gov/10623648/","study_design":null,"title":"Intraneuronal Abeta42 accumulation in human brain","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/endoproteolysis-of-presenilin-1-and-accumulation-of-processed-8755489","doi":"10.1016/s0896-6273(00)80291-3","journal":"Neuron","n_participants":null,"pmid":"8755489","source_url":"https://pubmed.ncbi.nlm.nih.gov/8755489/","study_design":null,"title":"Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo","title_match":true,"year":1996},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/efficient-introduction-of-specific-homozygous-and-heterozygous-27120160","doi":"10.1038/nature17664","journal":"Nature","n_participants":null,"pmid":"27120160","source_url":"https://pubmed.ncbi.nlm.nih.gov/27120160/","study_design":null,"title":"Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-mutation-in-the-amyloid-precursor-protein-associated-with-1925564","doi":"10.1126/science.1925564","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"1925564","source_url":"https://pubmed.ncbi.nlm.nih.gov/1925564/","study_design":null,"title":"A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease","title_match":false,"year":1991},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/unstable-expansion-of-cag-repeat-in-hereditary-dentatorubral-8136840","doi":"10.1038/ng0194-9","journal":"Nature genetics","n_participants":null,"pmid":"8136840","source_url":"https://pubmed.ncbi.nlm.nih.gov/8136840/","study_design":null,"title":"Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)","title_match":false,"year":1994},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/aph-1-pen-2-and-nicastrin-with-presenilin-generate-an-active-gamma-12691659","doi":"10.1016/s0896-6273(03)00205-8","journal":"Neuron","n_participants":null,"pmid":"12691659","source_url":"https://pubmed.ncbi.nlm.nih.gov/12691659/","study_design":null,"title":"Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex","title_match":true,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-deposition-precedes-tangle-formation-in-a-triple-transgenic-14643377","doi":"10.1016/j.neurobiolaging.2003.08.012","journal":"Neurobiology of aging","n_participants":null,"pmid":"14643377","source_url":"https://pubmed.ncbi.nlm.nih.gov/14643377/","study_design":null,"title":"Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/skeletal-and-cns-defects-in-presenilin-1-deficient-mice-9160754","doi":"10.1016/s0092-8674(00)80244-5","journal":"Cell","n_participants":null,"pmid":"9160754","source_url":"https://pubmed.ncbi.nlm.nih.gov/9160754/","study_design":null,"title":"Skeletal and CNS defects in Presenilin-1-deficient mice","title_match":true,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/early-onset-amyloid-deposition-and-cognitive-deficits-in-transgenic-11279122","doi":"10.1074/jbc.m100710200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"11279122","source_url":"https://pubmed.ncbi.nlm.nih.gov/11279122/","study_design":null,"title":"Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695","title_match":false,"year":2001},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/photoactivated-gamma-secretase-inhibitors-directed-to-the-active-site-10864326","doi":"10.1038/35015085","journal":"Nature","n_participants":null,"pmid":"10864326","source_url":"https://pubmed.ncbi.nlm.nih.gov/10864326/","study_design":null,"title":"Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1","title_match":true,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/reconstitution-of-gamma-secretase-activity-12679784","doi":"10.1038/ncb960","journal":"Nature cell biology","n_participants":null,"pmid":"12679784","source_url":"https://pubmed.ncbi.nlm.nih.gov/12679784/","study_design":null,"title":"Reconstitution of gamma-secretase activity","title_match":false,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-genetic-defect-causing-familial-alzheimer-s-disease-maps-on-2880399","doi":"10.1126/science.2880399","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"2880399","source_url":"https://pubmed.ncbi.nlm.nih.gov/2880399/","study_design":null,"title":"The genetic defect causing familial Alzheimer's disease maps on chromosome 21","title_match":true,"year":1987},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/decreased-nuclear-beta-catenin-tau-hyperphosphorylation-and-11226152","doi":"10.1093/emboj/20.1.27","journal":"The EMBO journal","n_participants":null,"pmid":"11226152","source_url":"https://pubmed.ncbi.nlm.nih.gov/11226152/","study_design":null,"title":"Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice","title_match":false,"year":2001},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-role-of-presenilin-cofactors-in-the-gamma-secretase-complex-12660785","doi":"10.1038/nature01506","journal":"Nature","n_participants":null,"pmid":"12660785","source_url":"https://pubmed.ncbi.nlm.nih.gov/12660785/","study_design":null,"title":"The role of presenilin cofactors in the gamma-secretase complex","title_match":true,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/app-mouse-models-for-alzheimer-s-disease-preclinical-studies-28768718","doi":"10.15252/embj.201797397","journal":"The EMBO journal","n_participants":null,"pmid":"28768718","source_url":"https://pubmed.ncbi.nlm.nih.gov/28768718/","study_design":null,"title":"APP mouse models for Alzheimer's disease preclinical studies","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-cell-biology-of-beta-amyloid-precursor-protein-and-presenilin-in-9854312","doi":"10.1016/s0962-8924(98)01363-4","journal":"Trends in cell biology","n_participants":null,"pmid":"9854312","source_url":"https://pubmed.ncbi.nlm.nih.gov/9854312/","study_design":null,"title":"The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease","title_match":true,"year":1998},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/presenilin-is-required-for-activity-and-nuclear-access-of-notch-in-10206646","doi":"10.1038/19091","journal":"Nature","n_participants":null,"pmid":"10206646","source_url":"https://pubmed.ncbi.nlm.nih.gov/10206646/","study_design":null,"title":"Presenilin is required for activity and nuclear access of Notch in Drosophila","title_match":true,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cell-biology-of-protein-misfolding-the-examples-of-alzheimer-s-and-15516999","doi":"10.1038/ncb1104-1054","journal":"Nature cell biology","n_participants":null,"pmid":"15516999","source_url":"https://pubmed.ncbi.nlm.nih.gov/15516999/","study_design":null,"title":"Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases","title_match":false,"year":2004},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/fibrils-formed-in-vitro-from-alpha-synuclein-and-two-mutant-forms-10704204","doi":"10.1021/bi991447r","journal":"Biochemistry","n_participants":null,"pmid":"10704204","source_url":"https://pubmed.ncbi.nlm.nih.gov/10704204/","study_design":null,"title":"Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/gamma-secretase-is-a-membrane-protein-complex-comprised-of-presenilin-12740439","doi":"10.1073/pnas.1037392100","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"12740439","source_url":"https://pubmed.ncbi.nlm.nih.gov/12740439/","study_design":null,"title":"Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2","title_match":true,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-disease-mitochondrial-cascade-hypothesis-progress-and-24071439","doi":"10.1016/j.bbadis.2013.09.010","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"24071439","source_url":"https://pubmed.ncbi.nlm.nih.gov/24071439/","study_design":null,"title":"The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/loss-of-presenilin-function-causes-impairments-of-memory-and-synaptic-15066262","doi":"10.1016/s0896-6273(04)00182-5","journal":"Neuron","n_participants":null,"pmid":"15066262","source_url":"https://pubmed.ncbi.nlm.nih.gov/15066262/","study_design":null,"title":"Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration","title_match":true,"year":2004},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/human-aspartic-protease-memapsin-2-cleaves-the-beta-secretase-site-of-10677483","doi":"10.1073/pnas.97.4.1456","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10677483","source_url":"https://pubmed.ncbi.nlm.nih.gov/10677483/","study_design":null,"title":"Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein","title_match":false,"year":2000},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/multiscale-analysis-of-independent-alzheimer-s-cohorts-finds-29937276","doi":"10.1016/j.neuron.2018.05.023","journal":"Neuron","n_participants":null,"pmid":"29937276","source_url":"https://pubmed.ncbi.nlm.nih.gov/29937276/","study_design":null,"title":"Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/modeling-alzheimer-s-disease-with-ipscs-reveals-stress-phenotypes-23434393","doi":"10.1016/j.stem.2013.01.009","journal":"Cell stem cell","n_participants":null,"pmid":"23434393","source_url":"https://pubmed.ncbi.nlm.nih.gov/23434393/","study_design":null,"title":"Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular A\u03b2 and differential drug responsiveness","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-presenilin-1-gamma-secretase-cleavage-releases-the-e-cadherin-11953314","doi":"10.1093/emboj/21.8.1948","journal":"The EMBO journal","n_participants":null,"pmid":"11953314","source_url":"https://pubmed.ncbi.nlm.nih.gov/11953314/","study_design":null,"title":"A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions","title_match":true,"year":2002},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genetic-linkage-evidence-for-a-familial-alzheimer-s-disease-locus-on-1411576","doi":"10.1126/science.1411576","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"1411576","source_url":"https://pubmed.ncbi.nlm.nih.gov/1411576/","study_design":null,"title":"Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14","title_match":true,"year":1992},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/disturbed-mitochondrial-dynamics-and-neurodegenerative-disorders-25486875","doi":"10.1038/nrneurol.2014.228","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"25486875","source_url":"https://pubmed.ncbi.nlm.nih.gov/25486875/","study_design":null,"title":"Disturbed mitochondrial dynamics and neurodegenerative disorders","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/comparison-of-kindreds-with-parkinsonism-and-alpha-synuclein-genomic-14755720","doi":"10.1002/ana.10846","journal":"Annals of neurology","n_participants":null,"pmid":"14755720","source_url":"https://pubmed.ncbi.nlm.nih.gov/14755720/","study_design":null,"title":"Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications","title_match":false,"year":2004},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/presenilin-1-is-required-for-notch1-and-dii1-expression-in-the-9153393","doi":"10.1038/387288a0","journal":"Nature","n_participants":null,"pmid":"9153393","source_url":"https://pubmed.ncbi.nlm.nih.gov/9153393/","study_design":null,"title":"Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm","title_match":true,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/beta-amyloid-precursor-protein-deficient-mice-show-reactive-gliosis-7758106","doi":"10.1016/0092-8674(95)90073-x","journal":"Cell","n_participants":null,"pmid":"7758106","source_url":"https://pubmed.ncbi.nlm.nih.gov/7758106/","study_design":null,"title":"beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity","title_match":false,"year":1995},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-multi-network-approach-identifies-protein-specific-co-expression-in-27989508","doi":"10.1016/j.cels.2016.11.006","journal":"Cell systems","n_participants":null,"pmid":"27989508","source_url":"https://pubmed.ncbi.nlm.nih.gov/27989508/","study_design":null,"title":"A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/oxidative-modifications-and-down-regulation-of-ubiquitin-carboxyl-14722078","doi":"10.1074/jbc.m314124200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"14722078","source_url":"https://pubmed.ncbi.nlm.nih.gov/14722078/","study_design":null,"title":"Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases","title_match":false,"year":2004},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/cholesterol-and-matrisome-pathways-dysregulated-in-astrocytes-and-35750033","doi":"10.1016/j.cell.2022.05.017","journal":"Cell","n_participants":null,"pmid":"35750033","source_url":"https://pubmed.ncbi.nlm.nih.gov/35750033/","study_design":null,"title":"Cholesterol and matrisome pathways dysregulated in astrocytes and microglia","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/epigenetic-age-of-the-pre-frontal-cortex-is-associated-with-neuritic-26684672","doi":"10.18632/aging.100864","journal":"Aging","n_participants":700,"pmid":"26684672","source_url":"https://pubmed.ncbi.nlm.nih.gov/26684672/","study_design":null,"title":"Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/age-specific-epigenetic-drift-in-late-onset-alzheimer-s-disease-18628954","doi":"10.1371/journal.pone.0002698","journal":"PloS one","n_participants":null,"pmid":"18628954","source_url":"https://pubmed.ncbi.nlm.nih.gov/18628954/","study_design":null,"title":"Age-specific epigenetic drift in late-onset Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/identification-of-vulnerable-cell-types-in-major-brain-disorders-26858593","doi":"10.3389/fnins.2016.00016","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"26858593","source_url":"https://pubmed.ncbi.nlm.nih.gov/26858593/","study_design":null,"title":"Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/selective-removal-of-astrocytic-apoe4-strongly-protects-against-tau-33831349","doi":"10.1016/j.neuron.2021.03.024","journal":"Neuron","n_participants":null,"pmid":"33831349","source_url":"https://pubmed.ncbi.nlm.nih.gov/33831349/","study_design":null,"title":"Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-single-cell-atlas-of-the-human-substantia-nigra-reveals-cell-32826893","doi":"10.1038/s41467-020-17876-0","journal":"Nature communications","n_participants":null,"pmid":"32826893","source_url":"https://pubmed.ncbi.nlm.nih.gov/32826893/","study_design":null,"title":"A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/a-large-panel-of-isogenic-app-and-psen1-mutant-human-ipsc-neurons-31416668","doi":"10.1016/j.neuron.2019.07.010","journal":"Neuron","n_participants":null,"pmid":"31416668","source_url":"https://pubmed.ncbi.nlm.nih.gov/31416668/","study_design":null,"title":"A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP \u03b2-CTFs, Not A\u03b2","title_match":true,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neuroprotective-actions-of-dietary-choline-28788094","doi":"10.3390/nu9080815","journal":"Nutrients","n_participants":null,"pmid":"28788094","source_url":"https://pubmed.ncbi.nlm.nih.gov/28788094/","study_design":null,"title":"Neuroprotective Actions of Dietary Choline","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/distinct-binding-of-pet-ligands-pbb3-and-av-1451-to-tau-fibril-28087578","doi":"10.1093/brain/aww339","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"28087578","source_url":"https://pubmed.ncbi.nlm.nih.gov/28087578/","study_design":null,"title":"Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/segregation-of-functional-networks-is-associated-with-cognitive-33725114","doi":"10.1093/brain/awab112","journal":"Brain : a journal of neurology","n_participants":108,"pmid":"33725114","source_url":"https://pubmed.ncbi.nlm.nih.gov/33725114/","study_design":null,"title":"Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/clinical-research-on-alzheimer-s-disease-progress-and-perspectives-29956105","doi":"10.1007/s12264-018-0249-z","journal":"Neuroscience bulletin","n_participants":null,"pmid":"29956105","source_url":"https://pubmed.ncbi.nlm.nih.gov/29956105/","study_design":null,"title":"Clinical Research on Alzheimer's Disease: Progress and Perspectives","title_match":false,"year":2018},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/trial-of-solanezumab-in-preclinical-alzheimer-s-disease-37458272","doi":"10.1056/nejmoa2305032","journal":"The New England journal of medicine","n_participants":1169,"pmid":"37458272","source_url":"https://pubmed.ncbi.nlm.nih.gov/37458272/","study_design":"clinical trial","title":"Trial of Solanezumab in Preclinical Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/regional-variability-of-imaging-biomarkers-in-autosomal-dominant-24194552","doi":"10.1073/pnas.1317918110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"24194552","source_url":"https://pubmed.ncbi.nlm.nih.gov/24194552/","study_design":"longitudinal study","title":"Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/a-new-amyloid-beta-variant-favoring-oligomerization-in-alzheimer-s-18300294","doi":"10.1002/ana.21321","journal":"Annals of neurology","n_participants":2121,"pmid":"18300294","source_url":"https://pubmed.ncbi.nlm.nih.gov/18300294/","study_design":null,"title":"A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-deposition-begins-in-the-striatum-of-presenilin-1-mutation-17553989","doi":"10.1523/jneurosci.0730-07.2007","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"17553989","source_url":"https://pubmed.ncbi.nlm.nih.gov/17553989/","study_design":null,"title":"Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees","title_match":true,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/binding-of-the-positron-emission-tomography-tracer-pittsburgh-16291932","doi":"10.1523/jneurosci.2990-05.2005","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"16291932","source_url":"https://pubmed.ncbi.nlm.nih.gov/16291932/","study_design":null,"title":"Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain","title_match":false,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/human-brain-networks-in-health-and-disease-19494774","doi":"10.1097/wco.0b013e32832d93dd","journal":"Current opinion in neurology","n_participants":null,"pmid":"19494774","source_url":"https://pubmed.ncbi.nlm.nih.gov/19494774/","study_design":null,"title":"Human brain networks in health and disease","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/functional-alterations-in-memory-networks-in-early-alzheimer-s-disease-20069392","doi":"10.1007/s12017-009-8109-7","journal":"Neuromolecular medicine","n_participants":null,"pmid":"20069392","source_url":"https://pubmed.ncbi.nlm.nih.gov/20069392/","study_design":null,"title":"Functional alterations in memory networks in early Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/presymptomatic-hippocampal-atrophy-in-alzheimer-s-disease-a-9010004","doi":"10.1093/brain/119.6.2001","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"9010004","source_url":"https://pubmed.ncbi.nlm.nih.gov/9010004/","study_design":"longitudinal study","title":"Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study","title_match":false,"year":1996},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/a-novel-imaging-marker-for-small-vessel-disease-based-on-27518166","doi":"10.1002/ana.24758","journal":"Annals of neurology","n_participants":113,"pmid":"27518166","source_url":"https://pubmed.ncbi.nlm.nih.gov/27518166/","study_design":"longitudinal study","title":"A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms","title_match":false,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/current-clinical-applications-of-in-vivo-gene-therapy-with-aavs-33309881","doi":"10.1016/j.ymthe.2020.12.007","journal":"Molecular therapy : the journal of the American Society of Gene Therapy","n_participants":null,"pmid":"33309881","source_url":"https://pubmed.ncbi.nlm.nih.gov/33309881/","study_design":null,"title":"Current Clinical Applications of In Vivo Gene Therapy with AAVs","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-role-of-copper-in-neurodegenerative-disease-10448050","doi":"10.1006/nbdi.1999.0250","journal":"Neurobiology of disease","n_participants":null,"pmid":"10448050","source_url":"https://pubmed.ncbi.nlm.nih.gov/10448050/","study_design":null,"title":"The role of copper in neurodegenerative disease","title_match":false,"year":1999},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/pink1-parkin-signalling-in-neurodegeneration-and-neuroinflammation-33168089","doi":"10.1186/s40478-020-01062-w","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"33168089","source_url":"https://pubmed.ncbi.nlm.nih.gov/33168089/","study_design":null,"title":"PINK1/PARKIN signalling in neurodegeneration and neuroinflammation","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/c-terminal-truncations-in-human-3-5-dna-exonuclease-trex1-cause-17660820","doi":"10.1038/ng2082","journal":"Nature genetics","n_participants":null,"pmid":"17660820","source_url":"https://pubmed.ncbi.nlm.nih.gov/17660820/","study_design":null,"title":"C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy","title_match":true,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-synucleins-11806835","doi":"10.1186/gb-2001-3-1-reviews3002","journal":"Genome biology","n_participants":null,"pmid":"11806835","source_url":"https://pubmed.ncbi.nlm.nih.gov/11806835/","study_design":null,"title":"The synucleins","title_match":false,"year":2002},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/procreative-beneficence-why-we-should-select-the-best-children-12058767","doi":"10.1111/1467-8519.00251","journal":"Bioethics","n_participants":null,"pmid":"12058767","source_url":"https://pubmed.ncbi.nlm.nih.gov/12058767/","study_design":null,"title":"Procreative beneficence: why we should select the best children","title_match":false,"year":2001},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/gba-gaucher-disease-and-parkinson-s-disease-from-genetic-to-clinic-to-31010158","doi":"10.3390/cells8040364","journal":"Cells","n_participants":null,"pmid":"31010158","source_url":"https://pubmed.ncbi.nlm.nih.gov/31010158/","study_design":null,"title":"GBA , Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/local-cellular-sources-of-apolipoprotein-e-in-the-human-retina-and-11384575","doi":"10.1016/s0002-9394(00)00961-2","journal":"American journal of ophthalmology","n_participants":null,"pmid":"11384575","source_url":"https://pubmed.ncbi.nlm.nih.gov/11384575/","study_design":null,"title":"Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation","title_match":false,"year":2001},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-parkinson-s-disease-caused-by-snca-duplications-26350119","doi":"10.1016/j.parkreldis.2015.09.007","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"26350119","source_url":"https://pubmed.ncbi.nlm.nih.gov/26350119/","study_design":null,"title":"Autosomal dominant Parkinson's disease caused by SNCA duplications","title_match":true,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/drosophila-melanogaster-as-a-model-organism-for-alzheimer-s-disease-24267573","doi":"10.1186/1750-1326-8-35","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"24267573","source_url":"https://pubmed.ncbi.nlm.nih.gov/24267573/","study_design":null,"title":"Drosophila melanogaster as a model organism for Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/ipsc-based-compound-screening-and-in-vitro-trials-identify-a-29166618","doi":"10.1016/j.celrep.2017.10.109","journal":"Cell reports","n_participants":null,"pmid":"29166618","source_url":"https://pubmed.ncbi.nlm.nih.gov/29166618/","study_design":null,"title":"iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid \u03b2 Combination for Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/dominantly-inherited-alzheimer-network-facilitating-research-and-24131566","doi":"10.1186/alzrt213","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"24131566","source_url":"https://pubmed.ncbi.nlm.nih.gov/24131566/","study_design":"longitudinal study","title":"Dominantly Inherited Alzheimer Network: facilitating research and clinical trials","title_match":true,"year":2013},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/measuring-cognition-and-function-in-the-preclinical-stage-of-29955653","doi":"10.1016/j.trci.2018.01.003","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"29955653","source_url":"https://pubmed.ncbi.nlm.nih.gov/29955653/","study_design":null,"title":"Measuring cognition and function in the preclinical stage of Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apoe-immunotherapy-reduces-cerebral-amyloid-angiopathy-and-amyloid-33597265","doi":"10.1126/scitranslmed.abd7522","journal":"Science translational medicine","n_participants":null,"pmid":"33597265","source_url":"https://pubmed.ncbi.nlm.nih.gov/33597265/","study_design":null,"title":"APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/three-major-effects-of-apoe-4-on-a-immunotherapy-induced-aria-38756535","doi":"10.3389/fnagi.2024.1412006","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"38756535","source_url":"https://pubmed.ncbi.nlm.nih.gov/38756535/","study_design":null,"title":"Three major effects of APOE \u03b54 on A\u03b2 immunotherapy induced ARIA","title_match":false,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/longitudinal-accumulation-of-cerebral-microhemorrhages-in-dominantly-33495373","doi":"10.1212/wnl.0000000000011542","journal":"Neurology","n_participants":310,"pmid":"33495373","source_url":"https://pubmed.ncbi.nlm.nih.gov/33495373/","study_design":"cross-sectional","title":"Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease","title_match":true,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/spontaneous-aria-amyloid-related-imaging-abnormalities-and-cerebral-25408217","doi":"10.3233/jad-142325","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25408217","source_url":"https://pubmed.ncbi.nlm.nih.gov/25408217/","study_design":null,"title":"Spontaneous ARIA (amyloid-related imaging abnormalities) and cerebral amyloid angiopathy related inflammation in presenilin 1-associated familial Alzheimer's disease","title_match":true,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/anti-amyloid-monoclonal-antibodies-for-alzheimer-s-disease-evidence-41003140","doi":"10.3390/jpm15090437","journal":"Journal of personalized medicine","n_participants":null,"pmid":"41003140","source_url":"https://pubmed.ncbi.nlm.nih.gov/41003140/","study_design":null,"title":"Anti-Amyloid Monoclonal Antibodies for Alzheimer's Disease: Evidence, ARIA Risk, and Precision Patient Selection","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/fda-approved-passive-immunization-treatments-against-a-in-alzheimer-s-41596530","doi":"10.3390/ijms27020883","journal":"International journal of molecular sciences","n_participants":null,"pmid":"41596530","source_url":"https://pubmed.ncbi.nlm.nih.gov/41596530/","study_design":null,"title":"FDA-Approved Passive Immunization Treatments Against A\u03b2 in Alzheimer's Disease: Where Are We Now?","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/a-novel-biochemical-analysis-for-apoe4-quantification-in-plasma-and-40671162","doi":"10.1186/s13195-025-01811-w","journal":"Alzheimer's research & therapy","n_participants":160,"pmid":"40671162","source_url":"https://pubmed.ncbi.nlm.nih.gov/40671162/","study_design":null,"title":"A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE \u03b54 carriers","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/comparison-of-the-neurofibrillary-pathology-in-alzheimer-s-disease-8811124","doi":"10.1007/s004010050487","journal":"Acta neuropathologica","n_participants":null,"pmid":"8811124","source_url":"https://pubmed.ncbi.nlm.nih.gov/8811124/","study_design":null,"title":"Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles","title_match":true,"year":1996},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/sorl1-deficiency-in-human-excitatory-neurons-causes-app-dependent-34133918","doi":"10.1016/j.celrep.2021.109259","journal":"Cell reports","n_participants":null,"pmid":"34133918","source_url":"https://pubmed.ncbi.nlm.nih.gov/34133918/","study_design":null,"title":"SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/clinical-advances-of-rna-therapeutics-for-treatment-of-neurological-35482908","doi":"10.1080/15476286.2022.2066334","journal":"RNA biology","n_participants":null,"pmid":"35482908","source_url":"https://pubmed.ncbi.nlm.nih.gov/35482908/","study_design":null,"title":"Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/facilitation-of-lin-12-mediated-signalling-by-sel-12-a-caenorhabditis-7566091","doi":"10.1038/377351a0","journal":"Nature","n_participants":null,"pmid":"7566091","source_url":"https://pubmed.ncbi.nlm.nih.gov/7566091/","study_design":null,"title":"Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene","title_match":false,"year":1995},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/human-presenilin-1-but-not-familial-alzheimer-s-disease-fad-mutants-9680315","doi":"10.1046/j.1365-4624.1997.00012.x","journal":"Genes and function","n_participants":null,"pmid":"9680315","source_url":"https://pubmed.ncbi.nlm.nih.gov/9680315/","study_design":null,"title":"Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing","title_match":true,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/val-8-glp-1-rescues-synaptic-plasticity-and-reduces-dense-core-20359773","doi":"10.1016/j.neurobiolaging.2010.02.014","journal":"Neurobiology of aging","n_participants":null,"pmid":"20359773","source_url":"https://pubmed.ncbi.nlm.nih.gov/20359773/","study_design":null,"title":"Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/hop-1-a-caenorhabditis-elegans-presenilin-appears-to-be-functionally-9342387","doi":"10.1073/pnas.94.22.12204","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9342387","source_url":"https://pubmed.ncbi.nlm.nih.gov/9342387/","study_design":null,"title":"HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling","title_match":true,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/evidence-for-a-physical-interaction-between-presenilin-and-notch-10077672","doi":"10.1073/pnas.96.6.3263","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10077672","source_url":"https://pubmed.ncbi.nlm.nih.gov/10077672/","study_design":null,"title":"Evidence for a physical interaction between presenilin and Notch","title_match":true,"year":1999},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/neural-correlates-of-liraglutide-effects-in-persons-at-risk-for-30099030","doi":"10.1016/j.bbr.2018.08.006","journal":"Behavioural brain research","n_participants":null,"pmid":"30099030","source_url":"https://pubmed.ncbi.nlm.nih.gov/30099030/","study_design":null,"title":"Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-incretin-hormones-glucagonlike-peptide-1-and-glucose-dependent-24529525","doi":"10.1016/j.jalz.2013.12.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"24529525","source_url":"https://pubmed.ncbi.nlm.nih.gov/24529525/","study_design":null,"title":"The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/aberrant-subcellular-neuronal-calcium-regulation-in-aging-and-20950656","doi":"10.1016/j.bbamcr.2010.10.005","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"20950656","source_url":"https://pubmed.ncbi.nlm.nih.gov/20950656/","study_design":null,"title":"Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/glucagon-like-peptide-1-cleavage-product-glp-1-9-36-amide-rescues-23035082","doi":"10.1523/jneurosci.2107-12.2012","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"23035082","source_url":"https://pubmed.ncbi.nlm.nih.gov/23035082/","study_design":null,"title":"Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/reverse-genetic-analysis-of-caenorhabditis-elegans-presenilins-10051671","doi":"10.1073/pnas.96.5.2497","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10051671","source_url":"https://pubmed.ncbi.nlm.nih.gov/10051671/","study_design":null,"title":"Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling","title_match":false,"year":1999},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/dysregulation-of-cholesterol-balance-in-the-brain-contribution-to-23065638","doi":"10.1242/dmm.010124","journal":"Disease models & mechanisms","n_participants":null,"pmid":"23065638","source_url":"https://pubmed.ncbi.nlm.nih.gov/23065638/","study_design":null,"title":"Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases","title_match":false,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/activation-of-wnt-signaling-by-lithium-and-rosiglitazone-reduced-19621015","doi":"10.1038/mp.2009.72","journal":"Molecular psychiatry","n_participants":null,"pmid":"19621015","source_url":"https://pubmed.ncbi.nlm.nih.gov/19621015/","study_design":null,"title":"Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/age-but-not-diagnosis-is-the-main-predictor-of-plasma-amyloid-beta-12873852","doi":"10.1001/archneur.60.7.958","journal":"Archives of neurology","n_participants":146,"pmid":"12873852","source_url":"https://pubmed.ncbi.nlm.nih.gov/12873852/","study_design":null,"title":"Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels","title_match":false,"year":2003},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/associations-between-potentially-modifiable-risk-factors-and-26079503","doi":"10.1371/journal.pmed.1001841","journal":"PLoS medicine","n_participants":17008,"pmid":"26079503","source_url":"https://pubmed.ncbi.nlm.nih.gov/26079503/","study_design":null,"title":"Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study","title_match":false,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/physical-activity-and-brain-health-31533339","doi":"10.3390/genes10090720","journal":"Genes","n_participants":null,"pmid":"31533339","source_url":"https://pubmed.ncbi.nlm.nih.gov/31533339/","study_design":null,"title":"Physical Activity and Brain Health","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/oxidative-stress-and-mitochondrial-dysfunction-linked-27809706","doi":"10.1080/01616412.2016.1251711","journal":"Neurological research","n_participants":null,"pmid":"27809706","source_url":"https://pubmed.ncbi.nlm.nih.gov/27809706/","study_design":null,"title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/pharmacological-inhibitors-of-glycogen-synthase-kinase-3-15559249","doi":"10.1016/j.tips.2004.07.006","journal":"Trends in pharmacological sciences","n_participants":null,"pmid":"15559249","source_url":"https://pubmed.ncbi.nlm.nih.gov/15559249/","study_design":null,"title":"Pharmacological inhibitors of glycogen synthase kinase 3","title_match":false,"year":2004},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/endoplasmic-reticulum-dysfunction-in-neurological-disease-23237905","doi":"10.1016/s1474-4422(12)70238-7","journal":"The Lancet. Neurology","n_participants":null,"pmid":"23237905","source_url":"https://pubmed.ncbi.nlm.nih.gov/23237905/","study_design":null,"title":"Endoplasmic reticulum dysfunction in neurological disease","title_match":false,"year":2013},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-endoplasmic-reticulum-stress-response-in-aging-and-age-related-22934019","doi":"10.3389/fphys.2012.00263","journal":"Frontiers in physiology","n_participants":null,"pmid":"22934019","source_url":"https://pubmed.ncbi.nlm.nih.gov/22934019/","study_design":null,"title":"The endoplasmic reticulum stress response in aging and age-related diseases","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuropathological-diagnostic-criteria-for-creutzfeldt-jakob-disease-8974629","doi":"10.1111/j.1750-3639.1995.tb00625.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"8974629","source_url":"https://pubmed.ncbi.nlm.nih.gov/8974629/","study_design":null,"title":"Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases)","title_match":false,"year":1995},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-syndrome-with-strokelike-episodes-and-1926242","doi":"10.1161/01.str.22.10.1297","journal":"Stroke","n_participants":null,"pmid":"1926242","source_url":"https://pubmed.ncbi.nlm.nih.gov/1926242/","study_design":null,"title":"Autosomal dominant syndrome with strokelike episodes and leukoencephalopathy","title_match":true,"year":1991},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/visual-impairment-and-cognitive-dysfunction-in-alzheimer-s-disease-2023019","doi":"10.1007/bf02598307","journal":"Journal of general internal medicine","n_participants":null,"pmid":"2023019","source_url":"https://pubmed.ncbi.nlm.nih.gov/2023019/","study_design":"case-control study","title":"Visual impairment and cognitive dysfunction in Alzheimer's disease","title_match":false,"year":1991},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genetics-functions-and-clinical-impact-of-presenilin-1-psen1-gene-36142879","doi":"10.3390/ijms231810970","journal":"International journal of molecular sciences","n_participants":null,"pmid":"36142879","source_url":"https://pubmed.ncbi.nlm.nih.gov/36142879/","study_design":null,"title":"Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cognitive-decline-dementia-alzheimer-s-disease-and-presbycusis-29937713","doi":"10.3389/fnins.2018.00394","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"29937713","source_url":"https://pubmed.ncbi.nlm.nih.gov/29937713/","study_design":null,"title":"Cognitive Decline, Dementia, Alzheimer's Disease and Presbycusis: Examination of the Possible Molecular Mechanism","title_match":false,"year":2018},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/genome-wide-association-meta-analysis-identifies-48-risk-variants-and-35580588","doi":"10.1016/j.ajhg.2022.04.010","journal":"American journal of human genetics","n_participants":723266,"pmid":"35580588","source_url":"https://pubmed.ncbi.nlm.nih.gov/35580588/","study_design":"meta-analysis","title":"Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-small-molecule-inhibitor-of-the-nlrp3-inflammasome-for-the-25686105","doi":"10.1038/nm.3806","journal":"Nature medicine","n_participants":null,"pmid":"25686105","source_url":"https://pubmed.ncbi.nlm.nih.gov/25686105/","study_design":null,"title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/curcumin-as-curecumin-from-kitchen-to-clinic-17900536","doi":"10.1016/j.bcp.2007.08.016","journal":"Biochemical pharmacology","n_participants":null,"pmid":"17900536","source_url":"https://pubmed.ncbi.nlm.nih.gov/17900536/","study_design":null,"title":"Curcumin as \"Curecumin\": from kitchen to clinic","title_match":false,"year":2008},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/glyburide-inhibits-the-cryopyrin-nalp3-inflammasome-19805629","doi":"10.1083/jcb.200903124","journal":"The Journal of cell biology","n_participants":null,"pmid":"19805629","source_url":"https://pubmed.ncbi.nlm.nih.gov/19805629/","study_design":null,"title":"Glyburide inhibits the Cryopyrin/Nalp3 inflammasome","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/impairing-the-mitochondrial-fission-and-fusion-balance-a-new-19076450","doi":"10.1196/annals.1427.030","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"19076450","source_url":"https://pubmed.ncbi.nlm.nih.gov/19076450/","study_design":null,"title":"Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetics-environmental-factors-and-the-emerging-role-of-epigenetics-19026668","doi":"10.1016/j.mrfmmm.2008.10.011","journal":"Mutation research","n_participants":null,"pmid":"19026668","source_url":"https://pubmed.ncbi.nlm.nih.gov/19026668/","study_design":null,"title":"Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases","title_match":false,"year":2009},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-canadian-study-of-health-and-aging-risk-factors-for-alzheimer-s-7969962","doi":"10.1212/wnl.44.11.2073","journal":"Neurology","n_participants":null,"pmid":"7969962","source_url":"https://pubmed.ncbi.nlm.nih.gov/7969962/","study_design":"case-control study","title":"The Canadian Study of Health and Aging: risk factors for Alzheimer's disease in Canada","title_match":false,"year":1994},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/environmental-risk-factors-for-parkinson-s-disease-and-parkinsonism-17332139","doi":"10.1136/oem.2006.027003","journal":"Occupational and environmental medicine","n_participants":null,"pmid":"17332139","source_url":"https://pubmed.ncbi.nlm.nih.gov/17332139/","study_design":"case-control study","title":"Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study","title_match":false,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/environmental-exposures-and-gene-regulation-in-disease-etiology-17805414","doi":"10.1289/ehp.9951","journal":"Environmental health perspectives","n_participants":null,"pmid":"17805414","source_url":"https://pubmed.ncbi.nlm.nih.gov/17805414/","study_design":null,"title":"Environmental exposures and gene regulation in disease etiology","title_match":false,"year":2007},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/hallmarks-of-alzheimer-disease-are-evolving-relentlessly-in-29587223","doi":"10.1016/j.envres.2018.03.023","journal":"Environmental research","n_participants":null,"pmid":"29587223","source_url":"https://pubmed.ncbi.nlm.nih.gov/29587223/","study_design":null,"title":"Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at \u2264 40 years of age","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuronal-death-and-survival-under-oxidative-stress-in-alzheimer-and-18220780","doi":"10.2174/187152707783399201","journal":"CNS & neurological disorders drug targets","n_participants":null,"pmid":"18220780","source_url":"https://pubmed.ncbi.nlm.nih.gov/18220780/","study_design":null,"title":"Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases","title_match":false,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apoe-genotype-and-alzheimer-s-disease-the-influence-of-lifestyle-and-34275270","doi":"10.1021/acschemneuro.1c00295","journal":"ACS chemical neuroscience","n_participants":null,"pmid":"34275270","source_url":"https://pubmed.ncbi.nlm.nih.gov/34275270/","study_design":null,"title":"APOE Genotype and Alzheimer's Disease: The Influence of Lifestyle and Environmental Factors","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/diesel-engine-exhaust-accelerates-plaque-formation-in-a-mouse-model-28854940","doi":"10.1186/s12989-017-0213-5","journal":"Particle and fibre toxicology","n_participants":null,"pmid":"28854940","source_url":"https://pubmed.ncbi.nlm.nih.gov/28854940/","study_design":null,"title":"Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/air-pollution-and-the-risk-of-parkinson-s-disease-a-review-35043999","doi":"10.1002/mds.28922","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"35043999","source_url":"https://pubmed.ncbi.nlm.nih.gov/35043999/","study_design":null,"title":"Air Pollution and the Risk of Parkinson's Disease: A Review","title_match":false,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/traffic-related-air-pollutants-trap-pm-promote-neuronal-31883973","doi":"10.1016/j.freeradbiomed.2019.12.023","journal":"Free radical biology & medicine","n_participants":null,"pmid":"31883973","source_url":"https://pubmed.ncbi.nlm.nih.gov/31883973/","study_design":null,"title":"Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts","title_match":false,"year":2020},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/risk-factors-for-creutzfeldt-jakob-disease-a-reanalysis-of-case-8628468","doi":"10.1212/wnl.46.5.1287","journal":"Neurology","n_participants":178,"pmid":"8628468","source_url":"https://pubmed.ncbi.nlm.nih.gov/8628468/","study_design":"case-control study","title":"Risk factors for Creutzfeldt-Jakob disease: a reanalysis of case-control studies","title_match":false,"year":1996},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/airborne-magnetite-and-iron-rich-pollution-nanoparticles-potential-31381513","doi":"10.3233/jad-190204","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31381513","source_url":"https://pubmed.ncbi.nlm.nih.gov/31381513/","study_design":null,"title":"Airborne Magnetite- and Iron-Rich Pollution Nanoparticles: Potential Neurotoxicants and Environmental Risk Factors for Neurodegenerative Disease, Including Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/decreases-in-short-term-memory-iq-and-altered-brain-metabolic-ratios-25633678","doi":"10.3233/jad-142685","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25633678","source_url":"https://pubmed.ncbi.nlm.nih.gov/25633678/","study_design":null,"title":"Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein \u03b54 Children Exposed to Air Pollution","title_match":false,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-in-lipoprotein-metabolism-health-and-cardiovascular-30598326","doi":"10.1016/j.pathol.2018.11.002","journal":"Pathology","n_participants":null,"pmid":"30598326","source_url":"https://pubmed.ncbi.nlm.nih.gov/30598326/","study_design":null,"title":"Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mapping-cortical-change-in-alzheimer-s-disease-brain-development-and-15501091","doi":"10.1016/j.neuroimage.2004.07.071","journal":"NeuroImage","n_participants":null,"pmid":"15501091","source_url":"https://pubmed.ncbi.nlm.nih.gov/15501091/","study_design":null,"title":"Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia","title_match":false,"year":2004},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-gsk3-hypothesis-of-alzheimer-s-disease-18088381","doi":"10.1111/j.1471-4159.2007.05194.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"18088381","source_url":"https://pubmed.ncbi.nlm.nih.gov/18088381/","study_design":null,"title":"The GSK3 hypothesis of Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neurodegenerative-diseases-and-oxidative-stress-14739060","doi":"10.1016/j.biopha.2003.11.004","journal":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","n_participants":null,"pmid":"14739060","source_url":"https://pubmed.ncbi.nlm.nih.gov/14739060/","study_design":null,"title":"Neurodegenerative diseases and oxidative stress","title_match":false,"year":2004},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-genotype-influences-the-gut-microbiome-structure-and-function-in-30958695","doi":"10.1096/fj.201900071r","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"30958695","source_url":"https://pubmed.ncbi.nlm.nih.gov/30958695/","study_design":null,"title":"APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-from-physiology-to-disease-and-back-30280653","doi":"10.1152/physrev.00050.2017","journal":"Physiological reviews","n_participants":null,"pmid":"30280653","source_url":"https://pubmed.ncbi.nlm.nih.gov/30280653/","study_design":null,"title":"Blood-Brain Barrier: From Physiology to Disease and Back","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/establishment-and-dysfunction-of-the-blood-brain-barrier-26590417","doi":"10.1016/j.cell.2015.10.067","journal":"Cell","n_participants":null,"pmid":"26590417","source_url":"https://pubmed.ncbi.nlm.nih.gov/26590417/","study_design":null,"title":"Establishment and Dysfunction of the Blood-Brain Barrier","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/identification-and-characterization-of-key-kinetic-intermediates-in-11580253","doi":"10.1006/jmbi.2001.4970","journal":"Journal of molecular biology","n_participants":null,"pmid":"11580253","source_url":"https://pubmed.ncbi.nlm.nih.gov/11580253/","study_design":null,"title":"Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis","title_match":false,"year":2001},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-is-phosphorylated-in-synucleinopathy-lesions-11813001","doi":"10.1038/ncb748","journal":"Nature cell biology","n_participants":null,"pmid":"11813001","source_url":"https://pubmed.ncbi.nlm.nih.gov/11813001/","study_design":null,"title":"alpha-Synuclein is phosphorylated in synucleinopathy lesions","title_match":false,"year":2002},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/aggregation-of-alpha-synuclein-in-lewy-bodies-of-sporadic-parkinson-s-9546347","doi":null,"journal":"The American journal of pathology","n_participants":null,"pmid":"9546347","source_url":"https://pubmed.ncbi.nlm.nih.gov/9546347/","study_design":null,"title":"Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies","title_match":false,"year":1998},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disease-amyloid-pores-from-pathogenic-mutations-12124613","doi":"10.1038/418291a","journal":"Nature","n_participants":null,"pmid":"12124613","source_url":"https://pubmed.ncbi.nlm.nih.gov/12124613/","study_design":null,"title":"Neurodegenerative disease: amyloid pores from pathogenic mutations","title_match":false,"year":2002},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurodegeneration-alzheimer-s-and-parkinson-s-diseases-the-prion-26250687","doi":"10.1126/science.1255555","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"26250687","source_url":"https://pubmed.ncbi.nlm.nih.gov/26250687/","study_design":null,"title":"NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A\u03b2, tau, and \u03b1-synuclein","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/exosomal-cell-to-cell-transmission-of-alpha-synuclein-oligomers-22920859","doi":"10.1186/1750-1326-7-42","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"22920859","source_url":"https://pubmed.ncbi.nlm.nih.gov/22920859/","study_design":null,"title":"Exosomal cell-to-cell transmission of alpha synuclein oligomers","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/fiber-diffraction-of-synthetic-alpha-synuclein-filaments-shows-10781096","doi":"10.1073/pnas.97.9.4897","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10781096","source_url":"https://pubmed.ncbi.nlm.nih.gov/10781096/","study_design":null,"title":"Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/enriched-environments-experience-dependent-plasticity-and-disorders-16924259","doi":"10.1038/nrn1970","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"16924259","source_url":"https://pubmed.ncbi.nlm.nih.gov/16924259/","study_design":null,"title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","title_match":false,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-amyloid-oligomer-bound-to-postsynaptic-prion-protein-22820466","doi":"10.1038/nn.3178","journal":"Nature neuroscience","n_participants":null,"pmid":"22820466","source_url":"https://pubmed.ncbi.nlm.nih.gov/22820466/","study_design":null,"title":"Alzheimer amyloid-\u03b2 oligomer bound to postsynaptic prion protein activates Fyn to impair neurons","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/metabotropic-glutamate-receptor-5-is-a-coreceptor-for-alzheimer-a-24012003","doi":"10.1016/j.neuron.2013.06.036","journal":"Neuron","n_participants":null,"pmid":"24012003","source_url":"https://pubmed.ncbi.nlm.nih.gov/24012003/","study_design":null,"title":"Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer a\u03b2 oligomer bound to cellular prion protein","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/suppression-of-eif2-kinases-alleviates-alzheimer-s-disease-related-23933749","doi":"10.1038/nn.3486","journal":"Nature neuroscience","n_participants":null,"pmid":"23933749","source_url":"https://pubmed.ncbi.nlm.nih.gov/23933749/","study_design":null,"title":"Suppression of eIF2\u03b1 kinases alleviates Alzheimer's disease-related plasticity and memory deficits","title_match":false,"year":2013},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-role-of-autophagy-in-neurodegenerative-disease-23921753","doi":"10.1038/nm.3232","journal":"Nature medicine","n_participants":null,"pmid":"23921753","source_url":"https://pubmed.ncbi.nlm.nih.gov/23921753/","study_design":null,"title":"The role of autophagy in neurodegenerative disease","title_match":false,"year":2013},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/mitochondrial-dynamics-fusion-fission-movement-and-mitophagy-in-19808793","doi":"10.1093/hmg/ddp326","journal":"Human molecular genetics","n_participants":null,"pmid":"19808793","source_url":"https://pubmed.ncbi.nlm.nih.gov/19808793/","study_design":null,"title":"Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/biological-and-chemical-approaches-to-diseases-of-proteostasis-19298183","doi":"10.1146/annurev.biochem.052308.114844","journal":"Annual review of biochemistry","n_participants":null,"pmid":"19298183","source_url":"https://pubmed.ncbi.nlm.nih.gov/19298183/","study_design":null,"title":"Biological and chemical approaches to diseases of proteostasis deficiency","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/glutathione-dysregulation-and-the-etiology-and-progression-of-human-19166318","doi":"10.1515/bc.2009.033","journal":"Biological chemistry","n_participants":null,"pmid":"19166318","source_url":"https://pubmed.ncbi.nlm.nih.gov/19166318/","study_design":null,"title":"Glutathione dysregulation and the etiology and progression of human diseases","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-ubiquitin-proteasome-system-in-neurodegenerative-diseases-14556719","doi":"10.1016/s0896-6273(03)00606-8","journal":"Neuron","n_participants":null,"pmid":"14556719","source_url":"https://pubmed.ncbi.nlm.nih.gov/14556719/","study_design":null,"title":"The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg","title_match":false,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mitochondria-oxidative-stress-and-neurodegeneration-22669122","doi":"10.1016/j.jns.2012.05.030","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"22669122","source_url":"https://pubmed.ncbi.nlm.nih.gov/22669122/","study_design":null,"title":"Mitochondria, oxidative stress and neurodegeneration","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-amnestic-mild-cognitive-impairment-and-age-18590347","doi":null,"journal":"Alternative medicine review : a journal of clinical therapeutic","n_participants":null,"pmid":"18590347","source_url":"https://pubmed.ncbi.nlm.nih.gov/18590347/","study_design":null,"title":"Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention","title_match":false,"year":2008},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/a-worldwide-study-of-the-huntington-s-disease-mutation-the-8159192","doi":"10.1056/nejm199405193302001","journal":"The New England journal of medicine","n_participants":1007,"pmid":"8159192","source_url":"https://pubmed.ncbi.nlm.nih.gov/8159192/","study_design":null,"title":"A worldwide study of the Huntington's disease mutation. The sensitivity and specificity of measuring CAG repeats","title_match":false,"year":1994},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetic-counseling-and-testing-for-alzheimer-disease-joint-practice-21577118","doi":"10.1097/gim.0b013e31821d69b8","journal":"Genetics in medicine : official journal of the American College of Medical Genetics","n_participants":null,"pmid":"21577118","source_url":"https://pubmed.ncbi.nlm.nih.gov/21577118/","study_design":null,"title":"Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/insulin-resistance-syndrome-in-children-15181020","doi":"10.1210/jc.2004-0276","journal":"The Journal of clinical endocrinology and metabolism","n_participants":null,"pmid":"15181020","source_url":"https://pubmed.ncbi.nlm.nih.gov/15181020/","study_design":null,"title":"Insulin resistance syndrome in children","title_match":false,"year":2004},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/imaging-of-onset-and-progression-of-alzheimer-s-disease-with-voxel-11476837","doi":"10.1016/s0140-6736(01)05408-3","journal":"Lancet (London, England)","n_participants":20,"pmid":"11476837","source_url":"https://pubmed.ncbi.nlm.nih.gov/11476837/","study_design":null,"title":"Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images","title_match":false,"year":2001},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-s-disease-findings-hypotheses-and-34460318","doi":"10.1146/annurev-pathmechdis-030421-112756","journal":"Annual review of pathology","n_participants":null,"pmid":"34460318","source_url":"https://pubmed.ncbi.nlm.nih.gov/34460318/","study_design":null,"title":"Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gabaergic-dysfunction-neural-network-hyperactivity-and-memory-33573856","doi":"10.1016/j.semcdb.2021.01.005","journal":"Seminars in cell & developmental biology","n_participants":null,"pmid":"33573856","source_url":"https://pubmed.ncbi.nlm.nih.gov/33573856/","study_design":null,"title":"GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/clinical-features-of-early-onset-alzheimer-disease-in-a-large-kindred-9052708","doi":"10.1001/jama.1997.03540340027028","journal":"JAMA","n_participants":128,"pmid":"9052708","source_url":"https://pubmed.ncbi.nlm.nih.gov/9052708/","study_design":null,"title":"Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation","title_match":true,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/parkinsonism-and-impaired-axonal-transport-in-a-mouse-model-of-18832465","doi":"10.1073/pnas.0808084105","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"18832465","source_url":"https://pubmed.ncbi.nlm.nih.gov/18832465/","study_design":null,"title":"Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-alpha-synucleinopathies-parkinson-s-disease-dementia-with-lewy-11193145","doi":"10.1111/j.1749-6632.2000.tb06900.x","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"11193145","source_url":"https://pubmed.ncbi.nlm.nih.gov/11193145/","study_design":null,"title":"The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/beta-amyloid-precursor-protein-metabolites-and-loss-of-neuronal-ca2-7504356","doi":"10.1016/0166-2236(93)90009-b","journal":"Trends in neurosciences","n_participants":null,"pmid":"7504356","source_url":"https://pubmed.ncbi.nlm.nih.gov/7504356/","study_design":null,"title":"beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease","title_match":false,"year":1993},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/amyloid-beta-protein-deposition-in-tissues-other-than-brain-in-2528696","doi":"10.1038/341226a0","journal":"Nature","n_participants":null,"pmid":"2528696","source_url":"https://pubmed.ncbi.nlm.nih.gov/2528696/","study_design":null,"title":"Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease","title_match":false,"year":1989},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/modeling-amyloid-beta-and-tau-pathology-in-human-cerebral-organoids-30171212","doi":"10.1038/s41380-018-0229-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"30171212","source_url":"https://pubmed.ncbi.nlm.nih.gov/30171212/","study_design":null,"title":"Modeling amyloid beta and tau pathology in human cerebral organoids","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/endosome-function-and-dysfunction-in-alzheimer-s-disease-and-other-15639316","doi":"10.1016/j.neurobiolaging.2004.09.018","journal":"Neurobiology of aging","n_participants":null,"pmid":"15639316","source_url":"https://pubmed.ncbi.nlm.nih.gov/15639316/","study_design":null,"title":"Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases","title_match":false,"year":2005},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/amyloid-beta-protein-precursor-gene-and-hereditary-cerebral-1971458","doi":"10.1126/science.1971458","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"1971458","source_url":"https://pubmed.ncbi.nlm.nih.gov/1971458/","study_design":null,"title":"Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)","title_match":false,"year":1990},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/genetics-of-amyloid-precursor-protein-in-alzheimer-s-disease-28003277","doi":"10.1101/cshperspect.a024539","journal":"Cold Spring Harbor perspectives in medicine","n_participants":null,"pmid":"28003277","source_url":"https://pubmed.ncbi.nlm.nih.gov/28003277/","study_design":null,"title":"Genetics of \u03b2-Amyloid Precursor Protein in Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/atypical-aging-in-down-syndrome-23949829","doi":"10.1002/ddrr.1128","journal":"Developmental disabilities research reviews","n_participants":210000,"pmid":"23949829","source_url":"https://pubmed.ncbi.nlm.nih.gov/23949829/","study_design":null,"title":"Atypical aging in Down syndrome","title_match":false,"year":2013},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-genetic-defect-in-familial-alzheimer-s-disease-is-not-tightly-2888020","doi":"10.1038/329156a0","journal":"Nature","n_participants":null,"pmid":"2888020","source_url":"https://pubmed.ncbi.nlm.nih.gov/2888020/","study_design":null,"title":"The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene","title_match":true,"year":1987},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/dyrk1a-a-dosage-sensitive-gene-involved-in-neurodevelopmental-27375444","doi":"10.3389/fnbeh.2016.00104","journal":"Frontiers in behavioral neuroscience","n_participants":null,"pmid":"27375444","source_url":"https://pubmed.ncbi.nlm.nih.gov/27375444/","study_design":null,"title":"DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-presenilins-in-the-nuclear-membrane-interphase-kinetochores-9298903","doi":"10.1016/s0092-8674(00)80356-6","journal":"Cell","n_participants":null,"pmid":"9298903","source_url":"https://pubmed.ncbi.nlm.nih.gov/9298903/","study_design":null,"title":"Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation","title_match":false,"year":1997},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-pattern-of-amyloid-accumulation-in-the-brains-of-adults-with-down-26362596","doi":"10.1016/j.jalz.2015.07.490","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26362596","source_url":"https://pubmed.ncbi.nlm.nih.gov/26362596/","study_design":null,"title":"The pattern of amyloid accumulation in the brains of adults with Down syndrome","title_match":false,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/superoxide-dismutase-activity-in-alzheimer-s-disease-possible-2521568","doi":"10.1016/0006-8993(89)91550-3","journal":"Brain research","n_participants":21,"pmid":"2521568","source_url":"https://pubmed.ncbi.nlm.nih.gov/2521568/","study_design":null,"title":"Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation","title_match":false,"year":1989},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/immune-hyporesponsiveness-to-amyloid-beta-peptide-in-amyloid-11517335","doi":"10.1073/pnas.191118298","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"11517335","source_url":"https://pubmed.ncbi.nlm.nih.gov/11517335/","study_design":null,"title":"Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease","title_match":false,"year":2001},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/amyloid-beta-protein-abeta-deposition-in-chromosome-14-linked-8773595","doi":"10.1002/ana.410400205","journal":"Annals of neurology","n_participants":null,"pmid":"8773595","source_url":"https://pubmed.ncbi.nlm.nih.gov/8773595/","study_design":null,"title":"Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43)","title_match":false,"year":1996},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-33848468","doi":"10.1016/s0140-6736(21)00218-x","journal":"Lancet (London, England)","n_participants":null,"pmid":"33848468","source_url":"https://pubmed.ncbi.nlm.nih.gov/33848468/","study_design":null,"title":"Parkinson's disease","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-plasma-p-tau181-p-tau231-and-glial-37268240","doi":"10.1016/j.nbd.2023.106175","journal":"Neurobiology of disease","n_participants":88,"pmid":"37268240","source_url":"https://pubmed.ncbi.nlm.nih.gov/37268240/","study_design":null,"title":"Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/genetic-and-environmental-contributions-to-variation-in-plasma-41231229","doi":"10.1002/alz.70906","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":6495,"pmid":"41231229","source_url":"https://pubmed.ncbi.nlm.nih.gov/41231229/","study_design":null,"title":"Genetic and environmental contributions to variation in plasma phosphorylated tau 217","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-predicts-in-vivo-brain-pathology-and-cognition-in-36571821","doi":"10.1002/alz.12906","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":24,"pmid":"36571821","source_url":"https://pubmed.ncbi.nlm.nih.gov/36571821/","study_design":null,"title":"Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/polygenic-scores-of-core-1-alzheimer-s-disease-biomarkers-predict-41307156","doi":"10.1002/alz.70937","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":515,"pmid":"41307156","source_url":"https://pubmed.ncbi.nlm.nih.gov/41307156/","study_design":"longitudinal study","title":"Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-p-tau231-in-the-presenilin-1-e280a-autosomal-dominant-40588692","doi":"10.1002/alz.70421","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40588692","source_url":"https://pubmed.ncbi.nlm.nih.gov/40588692/","study_design":"longitudinal study","title":"Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinical-and-demographic-factors-modify-the-association-between-39713247","doi":"10.1002/dad2.70047","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1185,"pmid":"39713247","source_url":"https://pubmed.ncbi.nlm.nih.gov/39713247/","study_design":null,"title":"Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition","title_match":false,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/temporal-order-of-clinical-and-biomarker-changes-in-familial-36138153","doi":"10.1038/s41591-022-01942-9","journal":"Nature medicine","n_participants":null,"pmid":"36138153","source_url":"https://pubmed.ncbi.nlm.nih.gov/36138153/","study_design":"longitudinal study","title":"Temporal order of clinical and biomarker changes in familial frontotemporal dementia","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-predicts-cerebellar-atrophy-and-33636389","doi":"10.1016/j.nbd.2021.105311","journal":"Neurobiology of disease","n_participants":62,"pmid":"33636389","source_url":"https://pubmed.ncbi.nlm.nih.gov/33636389/","study_design":null,"title":"Plasma neurofilament light chain predicts cerebellar atrophy and clinical progression in spinocerebellar ataxia","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/differential-associations-of-apoe-and-trem2-variants-with-glial-40659842","doi":"10.1038/s41380-025-03098-7","journal":"Molecular psychiatry","n_participants":50000,"pmid":"40659842","source_url":"https://pubmed.ncbi.nlm.nih.gov/40659842/","study_design":null,"title":"Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-risk-and-plasma-biomarkers-of-dementia-with-lewy-bodies-in-a-40374660","doi":"10.1038/s41531-025-00988-z","journal":"NPJ Parkinson's disease","n_participants":151,"pmid":"40374660","source_url":"https://pubmed.ncbi.nlm.nih.gov/40374660/","study_design":null,"title":"Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-plasma-concentration-predicts-31514172","doi":"10.18632/aging.102220","journal":"Aging","n_participants":null,"pmid":"31514172","source_url":"https://pubmed.ncbi.nlm.nih.gov/31514172/","study_design":"longitudinal study","title":"Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-polygenic-risk-the-plasma-proteome-and-dementia-39586964","doi":"10.1007/s11357-024-01413-8","journal":"GeroScience","n_participants":null,"pmid":"39586964","source_url":"https://pubmed.ncbi.nlm.nih.gov/39586964/","study_design":null,"title":"Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/heritability-of-alzheimer-s-disease-plasma-biomarkers-a-nuclear-twin-39588748","doi":"10.1002/alz.14269","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39588748","source_url":"https://pubmed.ncbi.nlm.nih.gov/39588748/","study_design":null,"title":"Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design","title_match":true,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/presymptomatic-plasma-biomarkers-in-autosomal-dominant-alzheimer-s-42637536","doi":"10.1136/jnnp-2026-339037","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":113,"pmid":"42637536","source_url":"https://pubmed.ncbi.nlm.nih.gov/42637536/","study_design":"cohort study","title":"Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing","title_match":true,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-trajectories-impact-of-ad-genetic-risk-and-clinical-40151521","doi":"10.1002/dad2.70081","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"40151521","source_url":"https://pubmed.ncbi.nlm.nih.gov/40151521/","study_design":"longitudinal study","title":"Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression","title_match":true,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-ratios-in-autosomal-dominant-alzheimer-s-disease-the-33892504","doi":"10.1093/brain/awab166","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"33892504","source_url":"https://pubmed.ncbi.nlm.nih.gov/33892504/","study_design":"cohort study","title":"Plasma amyloid-\u03b2 ratios in autosomal dominant Alzheimer's disease: the influence of genotype","title_match":true,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/development-of-a-three-dimensional-organoid-model-to-explore-early-37620502","doi":"10.1038/s41598-023-40382-4","journal":"Scientific reports","n_participants":null,"pmid":"37620502","source_url":"https://pubmed.ncbi.nlm.nih.gov/37620502/","study_design":null,"title":"Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/a-novel-v272d-presenilin-mutation-associated-with-logopenia-31500908","doi":"10.1016/j.neurobiolaging.2019.07.002","journal":"Neurobiology of aging","n_participants":null,"pmid":"31500908","source_url":"https://pubmed.ncbi.nlm.nih.gov/31500908/","study_design":null,"title":"A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family","title_match":true,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/patient-derived-psen1-cerebral-organoids-revealed-parallel-42477212","doi":"10.1007/s10571-026-01779-7","journal":"Cellular and molecular neurobiology","n_participants":null,"pmid":"42477212","source_url":"https://pubmed.ncbi.nlm.nih.gov/42477212/","study_design":null,"title":"Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-\u03b2 Accumulation and Network Dysfunction","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-pathogenicity-of-psen2-variants-is-tied-to-a-production-and-38979391","doi":"10.1101/2024.06.22.600217","journal":"bioRxiv : the preprint server for biology","n_participants":null,"pmid":"38979391","source_url":"https://pubmed.ncbi.nlm.nih.gov/38979391/","study_design":null,"title":"The pathogenicity of PSEN2 variants is tied to A\u03b2 production and homology to PSEN1","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-can-activate-jnk-signalling-via-wnt5a-ror2-to-reduce-synapse-39907042","doi":"10.1242/jcs.263526","journal":"Journal of cell science","n_participants":null,"pmid":"39907042","source_url":"https://pubmed.ncbi.nlm.nih.gov/39907042/","study_design":null,"title":"Amyloid-\u03b2 can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/glutamate-transporter-1-as-a-novel-negative-regulator-of-amyloid-39404364","doi":"10.3390/cells13191600","journal":"Cells","n_participants":null,"pmid":"39404364","source_url":"https://pubmed.ncbi.nlm.nih.gov/39404364/","study_design":null,"title":"Glutamate Transporter 1 as a Novel Negative Regulator of Amyloid \u03b2","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/pathogenic-ps1-phosphorylation-at-ser367-28132667","doi":"10.7554/elife.19720","journal":"eLife","n_participants":null,"pmid":"28132667","source_url":"https://pubmed.ncbi.nlm.nih.gov/28132667/","study_design":null,"title":"Pathogenic PS1 phosphorylation at Ser367","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/characteristics-of-discordance-between-amyloid-positron-emission-38341444","doi":"10.1038/s41398-024-02766-6","journal":"Translational psychiatry","n_participants":null,"pmid":"38341444","source_url":"https://pubmed.ncbi.nlm.nih.gov/38341444/","study_design":"cross-sectional","title":"Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-\u03b2 42/40 positivity","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/cerebral-amyloid-angiopathy-pathogenetic-mechanisms-and-link-to-dense-18184371","doi":"10.1111/j.1601-183x.2007.00380.x","journal":"Genes, brain, and behavior","n_participants":null,"pmid":"18184371","source_url":"https://pubmed.ncbi.nlm.nih.gov/18184371/","study_design":null,"title":"Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques","title_match":false,"year":2008},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/upregulation-of-endocytic-protein-expression-in-the-alzheimer-s-37449017","doi":"10.1016/j.nbas.2023.100084","journal":"Aging brain","n_participants":null,"pmid":"37449017","source_url":"https://pubmed.ncbi.nlm.nih.gov/37449017/","study_design":null,"title":"Upregulation of endocytic protein expression in the Alzheimer's disease male human brain","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/genetic-and-polygenic-risk-score-analysis-for-alzheimer-s-disease-in-32775599","doi":"10.1002/dad2.12074","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"32775599","source_url":"https://pubmed.ncbi.nlm.nih.gov/32775599/","study_design":"meta-analysis","title":"Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population","title_match":true,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/increased-h-bond-stability-relates-to-altered-cleavage-efficiency-and-30926830","doi":"10.1038/s41598-019-41766-1","journal":"Scientific reports","n_participants":null,"pmid":"30926830","source_url":"https://pubmed.ncbi.nlm.nih.gov/30926830/","study_design":null,"title":"Increased H-Bond Stability Relates to Altered \u03b5-Cleavage Efficiency and A\u03b2 Levels in the I45T Familial Alzheimer's Disease Mutant of APP","title_match":true,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/interrelationship-between-changes-in-the-amyloid-42-40-ratio-and-27391800","doi":"10.2119/molmed.2016.00127","journal":"Molecular medicine (Cambridge, Mass.)","n_participants":null,"pmid":"27391800","source_url":"https://pubmed.ncbi.nlm.nih.gov/27391800/","study_design":null,"title":"Interrelationship between Changes in the Amyloid \u03b2 42/40 Ratio and Presenilin 1 Conformation","title_match":true,"year":2016},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/cleavage-of-amyloid-precursor-protein-by-an-archaeal-presenilin-25733893","doi":"10.1073/pnas.1502150112","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"25733893","source_url":"https://pubmed.ncbi.nlm.nih.gov/25733893/","study_design":null,"title":"Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH","title_match":true,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-pathology-and-cognitive-impairment-in-ha-ki-and-appsaa-ki-39447490","doi":"10.1016/j.neurobiolaging.2024.10.005","journal":"Neurobiology of aging","n_participants":null,"pmid":"39447490","source_url":"https://pubmed.ncbi.nlm.nih.gov/39447490/","study_design":null,"title":"Amyloid pathology and cognitive impairment in hA\u03b2-KI and APPSAA-KI mouse models of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-beta-peptide-levels-in-laser-capture-microdissected-cornu-18596605","doi":"10.1097/wnr.0b013e328302c858","journal":"Neuroreport","n_participants":null,"pmid":"18596605","source_url":"https://pubmed.ncbi.nlm.nih.gov/18596605/","study_design":null,"title":"Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain","title_match":false,"year":2008},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/hereditary-and-sporadic-forms-of-abeta-cerebrovascular-amyloidosis-19468344","doi":"10.3390/ijms10041872","journal":"International journal of molecular sciences","n_participants":null,"pmid":"19468344","source_url":"https://pubmed.ncbi.nlm.nih.gov/19468344/","study_design":null,"title":"Hereditary and sporadic forms of abeta-cerebrovascular amyloidosis and relevant transgenic mouse models","title_match":false,"year":2009},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/psen2-mutation-spectrum-and-novel-functionally-validated-mutations-in-35491795","doi":"10.3233/jad-220194","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"35491795","source_url":"https://pubmed.ncbi.nlm.nih.gov/35491795/","study_design":null,"title":"PSEN2 Mutation Spectrum and Novel Functionally Validated Mutations in Alzheimer's Disease: Data from PUMCH Dementia Cohort","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/sheet-structure-within-the-extracellular-domain-of-c99-regulates-29215043","doi":"10.1038/s41598-017-17144-0","journal":"Scientific reports","n_participants":null,"pmid":"29215043","source_url":"https://pubmed.ncbi.nlm.nih.gov/29215043/","study_design":null,"title":"\u03b2-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/crispr-cas9-treatment-partially-restores-amyloid-42-40-in-human-35505961","doi":"10.1016/j.omtn.2022.03.022","journal":"Molecular therapy. Nucleic acids","n_participants":null,"pmid":"35505961","source_url":"https://pubmed.ncbi.nlm.nih.gov/35505961/","study_design":null,"title":"CRISPR-Cas9 treatment partially restores amyloid-\u03b2 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation","title_match":true,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-their-correlation-in-adult-children-of-parents-36110426","doi":"10.3389/fnagi.2022.977515","journal":"Frontiers in aging neuroscience","n_participants":99,"pmid":"36110426","source_url":"https://pubmed.ncbi.nlm.nih.gov/36110426/","study_design":"longitudinal study","title":"Plasma biomarkers and their correlation in adult children of parents with Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/liver-specific-polygenic-risk-score-is-associated-with-alzheimer-s-36744333","doi":"10.3233/jad-220599","journal":"Journal of Alzheimer's disease : JAD","n_participants":1115,"pmid":"36744333","source_url":"https://pubmed.ncbi.nlm.nih.gov/36744333/","study_design":"cohort study","title":"Liver-Specific Polygenic Risk Score Is Associated with Alzheimer's Disease Diagnosis","title_match":true,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neuropathology-based-apoe-genetic-risk-score-better-quantifies-36795776","doi":"10.1002/alz.12990","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36795776","source_url":"https://pubmed.ncbi.nlm.nih.gov/36795776/","study_design":null,"title":"Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genetic-risk-as-a-marker-of-amyloid-and-tau-burden-in-cerebrospinal-27834776","doi":"10.3233/jad-160707","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"27834776","source_url":"https://pubmed.ncbi.nlm.nih.gov/27834776/","study_design":null,"title":"Genetic Risk as a Marker of Amyloid-\u03b2 and Tau Burden in Cerebrospinal Fluid","title_match":true,"year":2017},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-in-familial-forms-of-alzheimer-s-25998699","doi":"10.1159/000381828","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"25998699","source_url":"https://pubmed.ncbi.nlm.nih.gov/25998699/","study_design":null,"title":"Cerebrospinal Fluid Biomarkers in Familial Forms of Alzheimer's Disease and Frontotemporal Dementia","title_match":true,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/memory-for-semantically-related-objects-differentiates-cognitively-36946459","doi":"10.14283/jpad.2023.14","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"36946459","source_url":"https://pubmed.ncbi.nlm.nih.gov/36946459/","study_design":null,"title":"Memory for Semantically Related Objects Differentiates Cognitively Unimpaired Autosomal Dominant Mutation Carriers from Non-Carrier Family Members","title_match":true,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/web-based-las-fname-and-blood-biomarkers-in-autosomal-dominant-41737720","doi":"10.1002/dad2.70289","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"41737720","source_url":"https://pubmed.ncbi.nlm.nih.gov/41737720/","study_design":"longitudinal study","title":"Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-cell-biology-of-apoe-in-the-brain-37805344","doi":"10.1016/j.tcb.2023.09.004","journal":"Trends in cell biology","n_participants":null,"pmid":"37805344","source_url":"https://pubmed.ncbi.nlm.nih.gov/37805344/","study_design":null,"title":"The cell biology of APOE in the brain","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-targeted-therapeutics-for-alzheimer-s-disease-41224653","doi":"10.1523/jneurosci.1388-25.2025","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"41224653","source_url":"https://pubmed.ncbi.nlm.nih.gov/41224653/","study_design":null,"title":"APOE-Targeted Therapeutics for Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amelioration-of-tau-and-apoe4-linked-glial-lipid-accumulation-and-37995685","doi":"10.1016/j.neuron.2023.10.023","journal":"Neuron","n_participants":null,"pmid":"37995685","source_url":"https://pubmed.ncbi.nlm.nih.gov/37995685/","study_design":null,"title":"Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-genotype-determines-cell-type-specific-pathological-landscape-of-40112813","doi":"10.1016/j.neuron.2025.02.017","journal":"Neuron","n_participants":null,"pmid":"40112813","source_url":"https://pubmed.ncbi.nlm.nih.gov/40112813/","study_design":null,"title":"APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/roles-of-apoe4-on-the-pathogenesis-in-alzheimer-s-disease-and-the-37227619","doi":"10.1007/s10571-023-01365-1","journal":"Cellular and molecular neurobiology","n_participants":null,"pmid":"37227619","source_url":"https://pubmed.ncbi.nlm.nih.gov/37227619/","study_design":null,"title":"Roles of ApoE4 on the Pathogenesis in Alzheimer's Disease and the Potential Therapeutic Approaches","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/microglial-apoe4-more-is-less-and-less-is-more-38115077","doi":"10.1186/s13024-023-00693-6","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"38115077","source_url":"https://pubmed.ncbi.nlm.nih.gov/38115077/","study_design":null,"title":"Microglial APOE4: more is less and less is more","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe2-protective-mechanism-and-therapeutic-implications-for-alzheimer-33148290","doi":"10.1186/s13024-020-00413-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"33148290","source_url":"https://pubmed.ncbi.nlm.nih.gov/33148290/","study_design":null,"title":"APOE2: protective mechanism and therapeutic implications for Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-from-astrocytes-restores-alzheimer-s-a-pathology-and-dam-like-39528861","doi":"10.1038/s44321-024-00162-7","journal":"EMBO molecular medicine","n_participants":null,"pmid":"39528861","source_url":"https://pubmed.ncbi.nlm.nih.gov/39528861/","study_design":null,"title":"APOE from astrocytes restores Alzheimer's A\u03b2-pathology and DAM-like responses in APOE deficient microglia","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-recognizes-alzheimer-s-disease-associated-3-o-37014788","doi":"10.1002/anie.202212636","journal":"Angewandte Chemie (International ed. in English)","n_participants":null,"pmid":"37014788","source_url":"https://pubmed.ncbi.nlm.nih.gov/37014788/","study_design":null,"title":"Apolipoprotein E Recognizes Alzheimer's Disease Associated 3-O Sulfation of Heparan Sulfate","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-isoform-dependent-effects-on-the-processing-of-34044125","doi":"10.1016/j.bbalip.2021.158980","journal":"Biochimica et biophysica acta. Molecular and cell biology of lipids","n_participants":null,"pmid":"34044125","source_url":"https://pubmed.ncbi.nlm.nih.gov/34044125/","study_design":null,"title":"Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-\u03b2","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-regulates-lipid-metabolism-and-synuclein-pathology-34453582","doi":"10.1007/s00401-021-02361-9","journal":"Acta neuropathologica","n_participants":null,"pmid":"34453582","source_url":"https://pubmed.ncbi.nlm.nih.gov/34453582/","study_design":null,"title":"Apolipoprotein E regulates lipid metabolism and \u03b1-synuclein pathology in human iPSC-derived cerebral organoids","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-interferes-with-iapp-aggregation-and-protects-31947546","doi":"10.3390/biom10010134","journal":"Biomolecules","n_participants":null,"pmid":"31947546","source_url":"https://pubmed.ncbi.nlm.nih.gov/31947546/","study_design":null,"title":"Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-glycosylation-and-sialylation-from-structure-39169951","doi":"10.3389/fnmol.2024.1399965","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"39169951","source_url":"https://pubmed.ncbi.nlm.nih.gov/39169951/","study_design":null,"title":"Human apolipoprotein E glycosylation and sialylation: from structure to function","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/aavrh-10-mediated-apoe2-central-nervous-system-gene-therapy-for-apoe4-29409358","doi":"10.1089/humc.2017.231","journal":"Human gene therapy. Clinical development","n_participants":null,"pmid":"29409358","source_url":"https://pubmed.ncbi.nlm.nih.gov/29409358/","study_design":null,"title":"AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-isoforms-are-differentially-sialylated-and-the-35041991","doi":"10.1016/j.nbd.2022.105631","journal":"Neurobiology of disease","n_participants":null,"pmid":"35041991","source_url":"https://pubmed.ncbi.nlm.nih.gov/35041991/","study_design":null,"title":"Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-A\u03b2 interaction and A\u03b2 fibrillation","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-increases-energy-metabolism-in-apoe-isogenic-ipsc-derived-39056789","doi":"10.3390/cells13141207","journal":"Cells","n_participants":null,"pmid":"39056789","source_url":"https://pubmed.ncbi.nlm.nih.gov/39056789/","study_design":null,"title":"APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons","title_match":false,"year":2024},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe-genotypes-differentially-remodel-the-astrocytic-lipid-droplet-40894647","doi":"10.1101/2025.08.19.669163","journal":"bioRxiv : the preprint server for biology","n_participants":null,"pmid":"40894647","source_url":"https://pubmed.ncbi.nlm.nih.gov/40894647/","study_design":null,"title":"APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/how-proteomic-apoe-serotyping-could-impact-alzheimer-s-disease-risk-24992828","doi":"10.1586/14789450.2014.936390","journal":"Expert review of proteomics","n_participants":null,"pmid":"24992828","source_url":"https://pubmed.ncbi.nlm.nih.gov/24992828/","study_design":null,"title":"How proteomic ApoE serotyping could impact Alzheimer's disease risk assessment: genetic testing by proteomics","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/molecular-recognition-of-the-interaction-between-apoe-and-the-trem2-35582645","doi":"10.1515/tnsci-2022-0218","journal":"Translational neuroscience","n_participants":null,"pmid":"35582645","source_url":"https://pubmed.ncbi.nlm.nih.gov/35582645/","study_design":null,"title":"Molecular recognition of the interaction between ApoE and the TREM2 protein","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/clinical-application-of-apoe-in-alzheimer-s-prevention-a-precision-30298183","doi":"10.14283/jpad.2018.35","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"30298183","source_url":"https://pubmed.ncbi.nlm.nih.gov/30298183/","study_design":null,"title":"Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach","title_match":false,"year":2018},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/validation-of-a-novel-and-accurate-apoe4-assay-for-automated-32034174","doi":"10.1038/s41598-020-58841-7","journal":"Scientific reports","n_participants":null,"pmid":"32034174","source_url":"https://pubmed.ncbi.nlm.nih.gov/32034174/","study_design":null,"title":"Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-has-extensive-conformational-heterogeneity-in-lipid-36749730","doi":"10.1073/pnas.2215371120","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"36749730","source_url":"https://pubmed.ncbi.nlm.nih.gov/36749730/","study_design":null,"title":"Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/interactions-between-apolipoprotein-e-metabolism-and-retinal-34210002","doi":"10.3390/life11070635","journal":"Life (Basel, Switzerland)","n_participants":null,"pmid":"34210002","source_url":"https://pubmed.ncbi.nlm.nih.gov/34210002/","study_design":null,"title":"Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-isoforms-differentially-regulates-cleavage-and-secretion-of-bdnf-28569173","doi":"10.1186/s13041-017-0301-3","journal":"Molecular brain","n_participants":null,"pmid":"28569173","source_url":"https://pubmed.ncbi.nlm.nih.gov/28569173/","study_design":null,"title":"ApoE isoforms differentially regulates cleavage and secretion of BDNF","title_match":false,"year":2017},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-lipidation-as-a-therapeutic-target-in-alzheimer-s-disease-32882843","doi":"10.3390/ijms21176336","journal":"International journal of molecular sciences","n_participants":null,"pmid":"32882843","source_url":"https://pubmed.ncbi.nlm.nih.gov/32882843/","study_design":null,"title":"ApoE Lipidation as a Therapeutic Target in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-interacts-with-ace2-inhibiting-sars-cov-2-cellular-entry-and-35915083","doi":"10.1038/s41392-022-01118-4","journal":"Signal transduction and targeted therapy","n_participants":19,"pmid":"35915083","source_url":"https://pubmed.ncbi.nlm.nih.gov/35915083/","study_design":null,"title":"APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients","title_match":false,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/effects-of-apoe4-and-apoe2-genotypes-on-subcortical-magnetic-34890142","doi":null,"journal":"Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing","n_participants":27535,"pmid":"34890142","source_url":"https://pubmed.ncbi.nlm.nih.gov/34890142/","study_design":null,"title":"Effects of ApoE4 and ApoE2 genotypes on subcortical magnetic susceptibility and microstructure in 27,535 participants from the UK Biobank","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/differential-and-substrate-specific-inhibition-of-secretase-by-the-c-37040764","doi":"10.1016/j.neuron.2023.03.024","journal":"Neuron","n_participants":null,"pmid":"37040764","source_url":"https://pubmed.ncbi.nlm.nih.gov/37040764/","study_design":null,"title":"Differential and substrate-specific inhibition of \u03b3-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-important-interface-between-apolipoprotein-e-and-32425941","doi":"10.3389/fimmu.2020.00754","journal":"Frontiers in immunology","n_participants":null,"pmid":"32425941","source_url":"https://pubmed.ncbi.nlm.nih.gov/32425941/","study_design":null,"title":"The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-increases-susceptibility-to-stress-induced-age-dependent-34530340","doi":"10.1016/j.jpsychires.2021.09.029","journal":"Journal of psychiatric research","n_participants":null,"pmid":"34530340","source_url":"https://pubmed.ncbi.nlm.nih.gov/34530340/","study_design":null,"title":"ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment","title_match":false,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-familial-dysbetalipoproteinemia-clinical-15630634","doi":"10.1055/s-2004-861492","journal":"Seminars in vascular medicine","n_participants":170,"pmid":"15630634","source_url":"https://pubmed.ncbi.nlm.nih.gov/15630634/","study_design":null,"title":"Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects","title_match":true,"year":2004},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/apoe-lipoprotein-particles-pathophysiology-therapy-and-the-crosstalk-41436721","doi":"10.1007/s12035-025-05629-3","journal":"Molecular neurobiology","n_participants":null,"pmid":"41436721","source_url":"https://pubmed.ncbi.nlm.nih.gov/41436721/","study_design":null,"title":"APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer's Disease and Cardiovascular Disease","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-genotypes-differentially-remodel-the-astrocytic-lipid-droplet-42749735","doi":"10.1038/s41467-026-76565-6","journal":"Nature communications","n_participants":null,"pmid":"42749735","source_url":"https://pubmed.ncbi.nlm.nih.gov/42749735/","study_design":null,"title":"APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-isoform-does-not-influence-trans-synaptic-spread-of-37600228","doi":"10.1177/23982128231191046","journal":"Brain and neuroscience advances","n_participants":null,"pmid":"37600228","source_url":"https://pubmed.ncbi.nlm.nih.gov/37600228/","study_design":null,"title":"Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-genotype-differentially-affects-olfactory-29678753","doi":"10.1016/j.neuroscience.2018.04.009","journal":"Neuroscience","n_participants":null,"pmid":"29678753","source_url":"https://pubmed.ncbi.nlm.nih.gov/29678753/","study_design":null,"title":"Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/amyloid-peptide-effects-on-glucose-regulation-are-dependent-on-37163733","doi":"10.1523/eneuro.0376-22.2023","journal":"eNeuro","n_participants":null,"pmid":"37163733","source_url":"https://pubmed.ncbi.nlm.nih.gov/37163733/","study_design":null,"title":"Amyloid \u03b2-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/impaired-cellular-copper-regulation-in-the-presence-of-apoe4-39135362","doi":"10.1111/jnc.16198","journal":"Journal of neurochemistry","n_participants":null,"pmid":"39135362","source_url":"https://pubmed.ncbi.nlm.nih.gov/39135362/","study_design":null,"title":"Impaired cellular copper regulation in the presence of ApoE4","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-apoe-4-status-moderates-the-relationship-between-33138883","doi":"10.1017/s1355617720001034","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":null,"pmid":"33138883","source_url":"https://pubmed.ncbi.nlm.nih.gov/33138883/","study_design":null,"title":"Apolipoprotein E (APOE) \u03b54 Status Moderates the Relationship Between Close-Range Blast Exposure and Cognitive Functioning","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/exceptional-longevity-modifying-allele-apoe2-promotes-dna-signaling-42103698","doi":"10.1111/acel.70494","journal":"Aging cell","n_participants":null,"pmid":"42103698","source_url":"https://pubmed.ncbi.nlm.nih.gov/42103698/","study_design":null,"title":"Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/understanding-the-role-of-apoe-fragments-in-alzheimer-s-disease-30225748","doi":"10.1007/s11064-018-2629-1","journal":"Neurochemical research","n_participants":null,"pmid":"30225748","source_url":"https://pubmed.ncbi.nlm.nih.gov/30225748/","study_design":null,"title":"Understanding the Role of ApoE Fragments in Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-affects-amyloid-formation-but-not-amyloid-growth-in-12000192","doi":"10.3109/13506120209072439","journal":"Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis","n_participants":null,"pmid":"12000192","source_url":"https://pubmed.ncbi.nlm.nih.gov/12000192/","study_design":null,"title":"Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease","title_match":false,"year":2002},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/unraveling-apoe4-s-role-in-alzheimer-s-disease-pathologies-and-39722484","doi":"10.2174/0113892037326839241014054430","journal":"Current protein & peptide science","n_participants":null,"pmid":"39722484","source_url":"https://pubmed.ncbi.nlm.nih.gov/39722484/","study_design":null,"title":"Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/when-time-s-arrow-doesn-t-bend-apoe-4-influences-episodic-memory-31473197","doi":"10.1016/j.neuropsychologia.2019.107180","journal":"Neuropsychologia","n_participants":null,"pmid":"31473197","source_url":"https://pubmed.ncbi.nlm.nih.gov/31473197/","study_design":null,"title":"When time's arrow doesn't bend: APOE-\u03b54 influences episodic memory before old age","title_match":false,"year":2019},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/apoe-variants-in-an-iberian-alzheimer-cohort-detected-through-an-33375167","doi":"10.3390/genes12010004","journal":"Genes","n_participants":null,"pmid":"33375167","source_url":"https://pubmed.ncbi.nlm.nih.gov/33375167/","study_design":"meta-analysis","title":"APOE Variants in an Iberian Alzheimer Cohort Detected through an Optimized Sanger Sequencing Protocol","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-isoforms-inhibit-amyloid-aggregation-of-proinflammatory-protein-38396791","doi":"10.3390/ijms25042114","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38396791","source_url":"https://pubmed.ncbi.nlm.nih.gov/38396791/","study_design":null,"title":"ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/reduced-binding-of-apoe4-to-complement-factor-h-promotes-amyloid-37155564","doi":"10.15252/embr.202256467","journal":"EMBO reports","n_participants":null,"pmid":"37155564","source_url":"https://pubmed.ncbi.nlm.nih.gov/37155564/","study_design":null,"title":"Reduced binding of apoE4 to complement factor H promotes amyloid-\u03b2 oligomerization and neuroinflammation","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/molecular-insight-into-the-therapeutic-promise-of-targeting-apoe4-for-32509144","doi":"10.1155/2020/5086250","journal":"Oxidative medicine and cellular longevity","n_participants":null,"pmid":"32509144","source_url":"https://pubmed.ncbi.nlm.nih.gov/32509144/","study_design":null,"title":"Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-4-the-most-prevalent-yet-understudied-risk-factor-for-alzheimer-25217293","doi":"10.1016/j.jalz.2014.06.015","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"25217293","source_url":"https://pubmed.ncbi.nlm.nih.gov/25217293/","study_design":null,"title":"APOE \u03b54: the most prevalent yet understudied risk factor for Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/mechanisms-linking-apolipoprotein-e-isoforms-with-cardiovascular-and-20531185","doi":"10.1097/mol.0b013e32833af368","journal":"Current opinion in lipidology","n_participants":null,"pmid":"20531185","source_url":"https://pubmed.ncbi.nlm.nih.gov/20531185/","study_design":null,"title":"Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases","title_match":false,"year":2010},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/impact-of-apolipoprotein-e-isoforms-on-sporadic-alzheimer-s-disease-37488848","doi":"10.4103/1673-5374.375316","journal":"Neural regeneration research","n_participants":null,"pmid":"37488848","source_url":"https://pubmed.ncbi.nlm.nih.gov/37488848/","study_design":null,"title":"Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-impairs-macrophage-lipophagy-and-promotes-demyelination-of-40258814","doi":"10.1038/s41420-025-02454-4","journal":"Cell death discovery","n_participants":null,"pmid":"40258814","source_url":"https://pubmed.ncbi.nlm.nih.gov/40258814/","study_design":null,"title":"APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-carrying-human-astrocytes-oversupply-cholesterol-to-promote-34450034","doi":"10.1016/j.stemcr.2021.07.017","journal":"Stem cell reports","n_participants":null,"pmid":"34450034","source_url":"https://pubmed.ncbi.nlm.nih.gov/34450034/","study_design":null,"title":"APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and A\u03b2 generation","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/sex-and-apoe-isoform-dependent-effects-of-radiation-on-cognitive-17149978","doi":"10.1667/rr0642.1","journal":"Radiation research","n_participants":null,"pmid":"17149978","source_url":"https://pubmed.ncbi.nlm.nih.gov/17149978/","study_design":null,"title":"Sex- and APOE isoform-dependent effects of radiation on cognitive function","title_match":false,"year":2006},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe4-accelerates-early-seeding-of-amyloid-pathology-29216449","doi":"10.1016/j.neuron.2017.11.013","journal":"Neuron","n_participants":null,"pmid":"29216449","source_url":"https://pubmed.ncbi.nlm.nih.gov/29216449/","study_design":null,"title":"ApoE4 Accelerates Early Seeding of Amyloid Pathology","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-4-expression-impairs-cerebral-vascularization-25335802","doi":"10.1038/jcbfm.2014.172","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"25335802","source_url":"https://pubmed.ncbi.nlm.nih.gov/25335802/","study_design":null,"title":"Human apolipoprotein E \u025b4 expression impairs cerebral vascularization and blood-brain barrier function in mice","title_match":false,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-as-vascular-risk-factor-in-neurodegenerative-dementia-15375590","doi":null,"journal":"International journal of molecular medicine","n_participants":null,"pmid":"15375590","source_url":"https://pubmed.ncbi.nlm.nih.gov/15375590/","study_design":null,"title":"Apolipoprotein E as vascular risk factor in neurodegenerative dementia","title_match":false,"year":2004},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-sets-the-stage-response-to-injury-triggers-23217737","doi":"10.1016/j.neuron.2012.11.020","journal":"Neuron","n_participants":null,"pmid":"23217737","source_url":"https://pubmed.ncbi.nlm.nih.gov/23217737/","study_design":null,"title":"Apolipoprotein e sets the stage: response to injury triggers neuropathology","title_match":false,"year":2012},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe-genotype-alters-glial-activation-and-loss-of-synaptic-markers-in-22228589","doi":"10.1002/glia.22289","journal":"Glia","n_participants":null,"pmid":"22228589","source_url":"https://pubmed.ncbi.nlm.nih.gov/22228589/","study_design":null,"title":"APOE genotype alters glial activation and loss of synaptic markers in mice","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-related-differences-in-cortical-thickness-are-modulated-by-sex-39196521","doi":"10.1007/s11682-024-00911-9","journal":"Brain imaging and behavior","n_participants":null,"pmid":"39196521","source_url":"https://pubmed.ncbi.nlm.nih.gov/39196521/","study_design":null,"title":"APOE4-related differences in cortical thickness are modulated by sex in middle age","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/brain-apolipoprotein-e-levels-in-mice-challenged-by-a-western-diet-38058491","doi":"10.1016/j.nbas.2023.100102","journal":"Aging brain","n_participants":null,"pmid":"38058491","source_url":"https://pubmed.ncbi.nlm.nih.gov/38058491/","study_design":null,"title":"Brain apolipoprotein E levels in mice challenged by a Western diet increase in an allele-dependent manner","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-isoform-specific-differences-in-neuronal-10582625","doi":"10.1046/j.1471-4159.1999.0732613.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"10582625","source_url":"https://pubmed.ncbi.nlm.nih.gov/10582625/","study_design":null,"title":"Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture","title_match":false,"year":1999},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/association-of-human-rat-and-rabbit-apolipoprotein-e-with-beta-amyloid-9211985","doi":null,"journal":"Journal of neuroscience research","n_participants":null,"pmid":"9211985","source_url":"https://pubmed.ncbi.nlm.nih.gov/9211985/","study_design":null,"title":"Association of human, rat, and rabbit apolipoprotein E with beta-amyloid","title_match":false,"year":1997},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/opposing-effects-of-apoe2-and-apoe4-on-glycolytic-metabolism-in-36766752","doi":"10.3390/cells12030410","journal":"Cells","n_participants":null,"pmid":"36766752","source_url":"https://pubmed.ncbi.nlm.nih.gov/36766752/","study_design":null,"title":"Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-analysis-of-alzheimer-s-disease-in-cases-without-30569081","doi":"10.14283/jpad.2018.46","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"30569081","source_url":"https://pubmed.ncbi.nlm.nih.gov/30569081/","study_design":null,"title":"Polygenic Risk Score Analysis of Alzheimer's Disease in Cases without APOE4 or APOE2 Alleles","title_match":true,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/tacrine-and-rate-of-progression-in-alzheimer-s-disease-relation-to-11475012","doi":"10.1007/s007020170066","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"11475012","source_url":"https://pubmed.ncbi.nlm.nih.gov/11475012/","study_design":null,"title":"Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype","title_match":false,"year":2001},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-multi-hit-hypothesis-for-an-apoe4-dependent-pathophysiological-state-35510513","doi":"10.1111/ejn.15685","journal":"The European journal of neuroscience","n_participants":null,"pmid":"35510513","source_url":"https://pubmed.ncbi.nlm.nih.gov/35510513/","study_design":null,"title":"A multi-hit hypothesis for an APOE4-dependent pathophysiological state","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/polygenic-effects-on-the-risk-of-alzheimer-s-disease-in-the-japanese-38414085","doi":"10.1186/s13195-024-01414-x","journal":"Alzheimer's research & therapy","n_participants":565,"pmid":"38414085","source_url":"https://pubmed.ncbi.nlm.nih.gov/38414085/","study_design":null,"title":"Polygenic effects on the risk of Alzheimer's disease in the Japanese population","title_match":true,"year":2024},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-provides-insights-into-the-genetic-41068259","doi":"10.1038/s41380-025-03295-4","journal":"Molecular psychiatry","n_participants":null,"pmid":"41068259","source_url":"https://pubmed.ncbi.nlm.nih.gov/41068259/","study_design":"meta-analysis","title":"Genome-wide association study provides insights into the genetic basis of Lewy body dementia","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/polygenic-score-modifies-risk-for-alzheimer-s-disease-in-apoe-4-34386572","doi":"10.1002/dad2.12226","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":213,"pmid":"34386572","source_url":"https://pubmed.ncbi.nlm.nih.gov/34386572/","study_design":null,"title":"Polygenic score modifies risk for Alzheimer's disease in APOE \u03b54 homozygotes at phenotypic extremes","title_match":true,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-brain-arteriolosclerosis-35156446","doi":"10.1177/0271678x211066299","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":3382,"pmid":"35156446","source_url":"https://pubmed.ncbi.nlm.nih.gov/35156446/","study_design":null,"title":"Genome-wide association study of brain arteriolosclerosis","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/gwas-of-multiple-neuropathology-endophenotypes-identifies-new-risk-39379761","doi":"10.1038/s41588-024-01939-9","journal":"Nature genetics","n_participants":7804,"pmid":"39379761","source_url":"https://pubmed.ncbi.nlm.nih.gov/39379761/","study_design":null,"title":"GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/ai-enabled-evaluation-of-genome-wide-association-relevance-and-38439972","doi":"10.1016/j.isci.2024.109209","journal":"iScience","n_participants":null,"pmid":"38439972","source_url":"https://pubmed.ncbi.nlm.nih.gov/38439972/","study_design":null,"title":"AI-enabled evaluation of genome-wide association relevance and polygenic risk score prediction in Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/genetic-influences-on-brain-and-cognitive-health-and-their-38890310","doi":"10.1038/s41467-024-49430-7","journal":"Nature communications","n_participants":null,"pmid":"38890310","source_url":"https://pubmed.ncbi.nlm.nih.gov/38890310/","study_design":"longitudinal study","title":"Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/alzheimer-s-polygenic-hazard-score-in-superagers-supergenes-or-35929001","doi":"10.1002/trc2.12321","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":37,"pmid":"35929001","source_url":"https://pubmed.ncbi.nlm.nih.gov/35929001/","study_design":null,"title":"Alzheimer's polygenic hazard score in SuperAgers: SuperGenes or SuperResilience?","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/polygenic-risk-and-pleiotropy-in-neurodegenerative-diseases-32445791","doi":"10.1016/j.nbd.2020.104953","journal":"Neurobiology of disease","n_participants":null,"pmid":"32445791","source_url":"https://pubmed.ncbi.nlm.nih.gov/32445791/","study_design":null,"title":"Polygenic risk and pleiotropy in neurodegenerative diseases","title_match":true,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/genorisk-a-polygenic-risk-score-for-alzheimer-s-disease-34621978","doi":"10.1002/trc2.12211","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"34621978","source_url":"https://pubmed.ncbi.nlm.nih.gov/34621978/","study_design":"case-control study","title":"GenoRisk: A polygenic risk score for Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-idiopathic-hypersomnia-in-a-japanese-38469065","doi":"10.1007/s41105-021-00349-2","journal":"Sleep and biological rhythms","n_participants":414,"pmid":"38469065","source_url":"https://pubmed.ncbi.nlm.nih.gov/38469065/","study_design":"meta-analysis","title":"Genome-wide association study of idiopathic hypersomnia in a Japanese population","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/fgwas-functional-genome-wide-association-analysis-28735012","doi":"10.1016/j.neuroimage.2017.07.030","journal":"NeuroImage","n_participants":708,"pmid":"28735012","source_url":"https://pubmed.ncbi.nlm.nih.gov/28735012/","study_design":null,"title":"FGWAS: Functional genome wide association analysis","title_match":false,"year":2017},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/benefits-and-challenges-of-rare-genetic-variation-in-alzheimer-s-39649954","doi":"10.1007/s40142-019-0161-5","journal":"Current genetic medicine reports","n_participants":null,"pmid":"39649954","source_url":"https://pubmed.ncbi.nlm.nih.gov/39649954/","study_design":null,"title":"Benefits and Challenges of Rare Genetic Variation in Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/whole-exome-rare-variant-analysis-of-alzheimer-s-disease-and-related-36464806","doi":"10.1002/alz.12842","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":450,"pmid":"36464806","source_url":"https://pubmed.ncbi.nlm.nih.gov/36464806/","study_design":null,"title":"Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genetics-of-common-cerebral-small-vessel-disease-34987231","doi":"10.1038/s41582-021-00592-8","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"34987231","source_url":"https://pubmed.ncbi.nlm.nih.gov/34987231/","study_design":null,"title":"Genetics of common cerebral small vessel disease","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/polygenic-risk-for-alzheimer-s-disease-shapes-hippocampal-scene-31896120","doi":"10.1038/s41386-019-0595-1","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":608,"pmid":"31896120","source_url":"https://pubmed.ncbi.nlm.nih.gov/31896120/","study_design":null,"title":"Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity","title_match":true,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/polygenic-score-for-alzheimer-s-disease-identifies-differential-35830443","doi":"10.1371/journal.pone.0270795","journal":"PloS one","n_participants":1086,"pmid":"35830443","source_url":"https://pubmed.ncbi.nlm.nih.gov/35830443/","study_design":null,"title":"Polygenic score for Alzheimer's disease identifies differential atrophy in hippocampal subfield volumes","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/integrative-multi-omics-approaches-identify-molecular-pathways-and-41231230","doi":"10.1002/alz.70886","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":15480,"pmid":"41231230","source_url":"https://pubmed.ncbi.nlm.nih.gov/41231230/","study_design":null,"title":"Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/shared-genetic-risk-loci-between-alzheimer-s-disease-and-related-37328865","doi":"10.1186/s13195-023-01244-3","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"37328865","source_url":"https://pubmed.ncbi.nlm.nih.gov/37328865/","study_design":null,"title":"Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/assessment-of-genetic-risk-for-improved-clinical-neuropathological-32912321","doi":"10.1186/s40478-020-01033-1","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"32912321","source_url":"https://pubmed.ncbi.nlm.nih.gov/32912321/","study_design":null,"title":"Assessment of genetic risk for improved clinical-neuropathological correlations","title_match":true,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/exploring-the-genetic-relationship-between-hearing-impairment-and-33005726","doi":"10.1002/dad2.12108","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"33005726","source_url":"https://pubmed.ncbi.nlm.nih.gov/33005726/","study_design":null,"title":"Exploring the genetic relationship between hearing impairment and Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/addressing-overlapping-sample-challenges-in-genome-wide-association-38168201","doi":"10.1101/2023.12.08.570867","journal":"PloS one","n_participants":null,"pmid":"38168201","source_url":"https://pubmed.ncbi.nlm.nih.gov/38168201/","study_design":null,"title":"Addressing Overlapping Sample Challenges in Genome-Wide Association Studies: Meta-Reductive Approach","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/genome-wide-association-studies-for-alzheimer-s-disease-bigger-is-not-35663382","doi":"10.1093/braincomms/fcac125","journal":"Brain communications","n_participants":null,"pmid":"35663382","source_url":"https://pubmed.ncbi.nlm.nih.gov/35663382/","study_design":null,"title":"Genome-wide association studies for Alzheimer's disease: bigger is not always better","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/polygenic-score-models-for-alzheimer-s-disease-from-research-to-33854414","doi":"10.3389/fnins.2021.650220","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"33854414","source_url":"https://pubmed.ncbi.nlm.nih.gov/33854414/","study_design":null,"title":"Polygenic Score Models for Alzheimer's Disease: From Research to Clinical Applications","title_match":true,"year":2021},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/polygenic-risk-and-hazard-scores-for-alzheimer-s-disease-prediction-30911569","doi":"10.1002/acn3.716","journal":"Annals of clinical and translational neurology","n_participants":null,"pmid":"30911569","source_url":"https://pubmed.ncbi.nlm.nih.gov/30911569/","study_design":null,"title":"Polygenic risk and hazard scores for Alzheimer's disease prediction","title_match":true,"year":2019},{"alzhub_score":82,"alzhub_url":"https://alzhub.org/study/whole-genome-sequencing-reveals-novel-ethnicity-specific-rare-35264725","doi":"10.1038/s41380-022-01483-0","journal":"Molecular psychiatry","n_participants":140,"pmid":"35264725","source_url":"https://pubmed.ncbi.nlm.nih.gov/35264725/","study_design":"meta-analysis","title":"Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/polygenic-effect-on-tau-pathology-progression-in-alzheimer-s-disease-36571564","doi":"10.1002/ana.26588","journal":"Annals of neurology","n_participants":85,"pmid":"36571564","source_url":"https://pubmed.ncbi.nlm.nih.gov/36571564/","study_design":"longitudinal study","title":"Polygenic Effect on Tau Pathology Progression in Alzheimer's Disease","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genome-wide-association-of-polygenic-risk-extremes-for-alzheimer-s-35589863","doi":"10.1038/s41598-022-12391-2","journal":"Scientific reports","n_participants":null,"pmid":"35589863","source_url":"https://pubmed.ncbi.nlm.nih.gov/35589863/","study_design":null,"title":"Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/genetic-risk-in-alzheimer-s-disease-41690978","doi":"10.1038/s41540-026-00665-8","journal":"NPJ systems biology and applications","n_participants":null,"pmid":"41690978","source_url":"https://pubmed.ncbi.nlm.nih.gov/41690978/","study_design":null,"title":"Genetic risk in Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-of-alzheimer-s-disease-is-associated-with-40959898","doi":"10.1002/alz.70660","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1634,"pmid":"40959898","source_url":"https://pubmed.ncbi.nlm.nih.gov/40959898/","study_design":null,"title":"Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/gwas-and-beyond-using-omics-approaches-to-interpret-snp-associations-33312764","doi":"10.1007/s40142-019-0159-z","journal":"Current genetic medicine reports","n_participants":null,"pmid":"33312764","source_url":"https://pubmed.ncbi.nlm.nih.gov/33312764/","study_design":null,"title":"GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations","title_match":false,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/polygenic-score-for-alzheimer-disease-and-cognition-the-mediating-30384091","doi":"10.1016/j.jpsychires.2018.10.015","journal":"Journal of psychiatric research","n_participants":null,"pmid":"30384091","source_url":"https://pubmed.ncbi.nlm.nih.gov/30384091/","study_design":null,"title":"Polygenic Score for Alzheimer Disease and cognition: The mediating role of personality","title_match":true,"year":2018},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/multi-ancestry-meta-analysis-and-fine-mapping-in-alzheimer-s-disease-37198259","doi":"10.1038/s41380-023-02089-w","journal":"Molecular psychiatry","n_participants":null,"pmid":"37198259","source_url":"https://pubmed.ncbi.nlm.nih.gov/37198259/","study_design":"meta-analysis","title":"Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genetic-insights-into-immune-mechanisms-of-alzheimer-s-and-parkinson-37359515","doi":"10.3389/fimmu.2023.1168539","journal":"Frontiers in immunology","n_participants":null,"pmid":"37359515","source_url":"https://pubmed.ncbi.nlm.nih.gov/37359515/","study_design":null,"title":"Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-as-a-possible-tool-for-identifying-familial-35460399","doi":"10.1016/j.gim.2022.03.022","journal":"Genetics in medicine : official journal of the American College of Medical Genetics","n_participants":null,"pmid":"35460399","source_url":"https://pubmed.ncbi.nlm.nih.gov/35460399/","study_design":null,"title":"Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases","title_match":true,"year":2022},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/consensus-meta-analysis-of-genome-wide-association-studies-for-41282675","doi":"10.1101/2025.10.20.25338060","journal":"medRxiv : the preprint server for health sciences","n_participants":null,"pmid":"41282675","source_url":"https://pubmed.ncbi.nlm.nih.gov/41282675/","study_design":"meta-analysis","title":"Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/pathway-specific-polygenic-risk-scores-correlate-with-clinical-status-37661888","doi":"10.3233/jad-230548","journal":"Journal of Alzheimer's disease : JAD","n_participants":1411,"pmid":"37661888","source_url":"https://pubmed.ncbi.nlm.nih.gov/37661888/","study_design":null,"title":"Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/atrial-fibrillation-genetics-update-toward-clinical-implementation-31552271","doi":"10.3389/fcvm.2019.00127","journal":"Frontiers in cardiovascular medicine","n_participants":null,"pmid":"31552271","source_url":"https://pubmed.ncbi.nlm.nih.gov/31552271/","study_design":null,"title":"Atrial Fibrillation Genetics Update: Toward Clinical Implementation","title_match":false,"year":2019},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/genome-wide-association-of-tau-neuroimaging-and-plasma-biomarkers-in-40667715","doi":"10.1002/alz.70398","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":375,"pmid":"40667715","source_url":"https://pubmed.ncbi.nlm.nih.gov/40667715/","study_design":null,"title":"Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/phenome-wide-association-study-of-polygenic-risk-score-for-alzheimer-35370621","doi":"10.3389/fnagi.2022.800375","journal":"Frontiers in aging neuroscience","n_participants":1515,"pmid":"35370621","source_url":"https://pubmed.ncbi.nlm.nih.gov/35370621/","study_design":null,"title":"Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer's Disease in Electronic Health Records","title_match":true,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/missense-and-loss-of-function-variants-at-gwas-loci-in-familial-39233587","doi":"10.1002/alz.14221","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39233587","source_url":"https://pubmed.ncbi.nlm.nih.gov/39233587/","study_design":null,"title":"Missense and loss-of-function variants at GWAS loci in familial Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/molecular-genetics-of-neuropsychiatric-illness-some-musings-38028602","doi":"10.3389/fgene.2023.1203017","journal":"Frontiers in genetics","n_participants":null,"pmid":"38028602","source_url":"https://pubmed.ncbi.nlm.nih.gov/38028602/","study_design":null,"title":"Molecular genetics of neuropsychiatric illness: some musings","title_match":false,"year":2023},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-drivers-of-progression-in-alzheimer-s-disease-are-distinct-41332834","doi":"10.1101/2025.11.17.25340247","journal":"medRxiv : the preprint server for health sciences","n_participants":222,"pmid":"41332834","source_url":"https://pubmed.ncbi.nlm.nih.gov/41332834/","study_design":"meta-analysis","title":"Genetic drivers of progression in Alzheimer's disease are distinct from disease risk","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/machine-learning-suggests-polygenic-risk-for-cognitive-dysfunction-in-33270986","doi":"10.15252/emmm.202012595","journal":"EMBO molecular medicine","n_participants":327,"pmid":"33270986","source_url":"https://pubmed.ncbi.nlm.nih.gov/33270986/","study_design":"longitudinal study","title":"Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis","title_match":true,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/genome-wide-association-neural-networks-identify-genes-linked-to-39775791","doi":"10.1093/bib/bbae704","journal":"Briefings in bioinformatics","n_participants":42,"pmid":"39775791","source_url":"https://pubmed.ncbi.nlm.nih.gov/39775791/","study_design":null,"title":"Genome-wide association neural networks identify genes linked to family history of Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/novel-alzheimer-s-disease-genes-and-epistasis-identified-using-37848535","doi":"10.1038/s41598-023-44378-y","journal":"Scientific reports","n_participants":null,"pmid":"37848535","source_url":"https://pubmed.ncbi.nlm.nih.gov/37848535/","study_design":null,"title":"Novel Alzheimer's disease genes and epistasis identified using machine learning GWAS platform","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/coping-with-brain-amyloid-genetic-heterogeneity-and-cognitive-33757599","doi":"10.1186/s40478-021-01154-1","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"33757599","source_url":"https://pubmed.ncbi.nlm.nih.gov/33757599/","study_design":"longitudinal study","title":"Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/polygenic-risk-scores-in-alzheimer-s-disease-genetics-methodology-35848019","doi":"10.3233/jad-220025","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"35848019","source_url":"https://pubmed.ncbi.nlm.nih.gov/35848019/","study_design":null,"title":"Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/leukocyte-telomere-length-shortening-and-alzheimer-s-disease-etiology-31156167","doi":"10.3233/jad-190134","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31156167","source_url":"https://pubmed.ncbi.nlm.nih.gov/31156167/","study_design":null,"title":"Leukocyte Telomere Length Shortening and Alzheimer's Disease Etiology","title_match":false,"year":2019},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/biobank-wide-association-scan-identifies-risk-factors-for-late-onset-38787369","doi":"10.7554/elife.91360","journal":"eLife","n_participants":61212,"pmid":"38787369","source_url":"https://pubmed.ncbi.nlm.nih.gov/38787369/","study_design":null,"title":"Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-polygenic-risk-score-as-a-predictor-of-conversion-31127079","doi":"10.1038/s41398-019-0485-7","journal":"Translational psychiatry","n_participants":122,"pmid":"31127079","source_url":"https://pubmed.ncbi.nlm.nih.gov/31127079/","study_design":null,"title":"Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment","title_match":true,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/genome-wide-association-and-interaction-studies-of-csf-t-tau-a42-28641921","doi":"10.1016/j.neurobiolaging.2017.05.007","journal":"Neurobiology of aging","n_participants":843,"pmid":"28641921","source_url":"https://pubmed.ncbi.nlm.nih.gov/28641921/","study_design":null,"title":"Genome-wide association and interaction studies of CSF T-tau/A\u03b242 ratio in ADNI cohort","title_match":false,"year":2017},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-polygenic-risk-score-predicts-mosaic-loss-of-chromosome-y-in-34895331","doi":"10.1186/s13578-021-00716-z","journal":"Cell & bioscience","n_participants":null,"pmid":"34895331","source_url":"https://pubmed.ncbi.nlm.nih.gov/34895331/","study_design":null,"title":"A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells","title_match":true,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/genetic-risk-factors-for-the-posterior-cortical-atrophy-variant-of-26993346","doi":"10.1016/j.jalz.2016.01.010","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26993346","source_url":"https://pubmed.ncbi.nlm.nih.gov/26993346/","study_design":null,"title":"Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease","title_match":true,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genetic-disease-amongst-the-plain-community-39254670","doi":"10.1097/mop.0000000000001392","journal":"Current opinion in pediatrics","n_participants":null,"pmid":"39254670","source_url":"https://pubmed.ncbi.nlm.nih.gov/39254670/","study_design":null,"title":"Genetic disease amongst the Plain community","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/genetic-risk-factors-for-alzheimer-disease-emerging-roles-of-30747419","doi":"10.1007/978-3-030-05542-4_5","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"30747419","source_url":"https://pubmed.ncbi.nlm.nih.gov/30747419/","study_design":null,"title":"Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms","title_match":true,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/shared-genes-and-pathways-in-dementia-insights-from-genome-wide-41198606","doi":"10.1002/alz.70845","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41198606","source_url":"https://pubmed.ncbi.nlm.nih.gov/41198606/","study_design":null,"title":"Shared genes and pathways in dementia: Insights from genome-wide association studies","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genetic-effects-and-gene-by-education-interactions-on-episodic-memory-30449520","doi":"10.1016/j.socscimed.2018.11.019","journal":"Social science & medicine (1982)","n_participants":null,"pmid":"30449520","source_url":"https://pubmed.ncbi.nlm.nih.gov/30449520/","study_design":null,"title":"Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/identifying-genes-associated-with-alzheimer-s-disease-using-gene-38007651","doi":"10.3233/jad-230510","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"38007651","source_url":"https://pubmed.ncbi.nlm.nih.gov/38007651/","study_design":null,"title":"Identifying Genes Associated with Alzheimer's Disease Using Gene-Based Polygenic Risk Score","title_match":true,"year":2023},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-alzheimer-s-disease-csf-biomarkers-33223526","doi":"10.1038/s41398-020-01074-z","journal":"Translational psychiatry","n_participants":931,"pmid":"33223526","source_url":"https://pubmed.ncbi.nlm.nih.gov/33223526/","study_design":"case-control study","title":"Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset","title_match":false,"year":2020},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/genetic-risk-loci-for-parkinson-s-disease-and-dementia-in-a-large-41810385","doi":"10.1016/j.lanwpc.2026.101825","journal":"The Lancet regional health. Western Pacific","n_participants":null,"pmid":"41810385","source_url":"https://pubmed.ncbi.nlm.nih.gov/41810385/","study_design":"case-control study","title":"Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI)","title_match":true,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-genetic-architecture-of-alzheimer-disease-risk-in-the-ohio-and-35599847","doi":"10.1016/j.xhgg.2022.100114","journal":"HGG advances","n_participants":null,"pmid":"35599847","source_url":"https://pubmed.ncbi.nlm.nih.gov/35599847/","study_design":null,"title":"The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-and-cluster-based-analysis-suggests-links-41258170","doi":"10.1038/s41467-025-65252-7","journal":"Nature communications","n_participants":null,"pmid":"41258170","source_url":"https://pubmed.ncbi.nlm.nih.gov/41258170/","study_design":null,"title":"Polygenic risk score and cluster-based analysis suggests links between type 2 diabetes and vascular dementia in the KARE study","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genetic-risk-variants-beyond-apoe-4-predict-28983503","doi":"10.1016/j.dadm.2017.07.002","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"28983503","source_url":"https://pubmed.ncbi.nlm.nih.gov/28983503/","study_design":"case-control study","title":"Alzheimer's disease genetic risk variants beyond APOE \u03b54 predict mortality","title_match":true,"year":2017},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-s-disease-the-importance-of-polygenic-and-28825204","doi":"10.1007/s11910-017-0787-1","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"28825204","source_url":"https://pubmed.ncbi.nlm.nih.gov/28825204/","study_design":null,"title":"Genetics of Alzheimer's Disease: the Importance of Polygenic and Epistatic Components","title_match":true,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/genetic-risk-scores-enhance-the-diagnostic-value-of-plasma-biomarkers-37279785","doi":"10.1093/brain/awad196","journal":"Brain : a journal of neurology","n_participants":962,"pmid":"37279785","source_url":"https://pubmed.ncbi.nlm.nih.gov/37279785/","study_design":null,"title":"Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis","title_match":true,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/leveraging-local-identity-by-descent-increases-the-power-of-case-25544865","doi":"10.1214/14-aoas715","journal":"The annals of applied statistics","n_participants":null,"pmid":"25544865","source_url":"https://pubmed.ncbi.nlm.nih.gov/25544865/","study_design":null,"title":"LEVERAGING LOCAL IDENTITY-BY-DESCENT INCREASES THE POWER OF CASE/CONTROL GWAS WITH RELATED INDIVIDUALS","title_match":false,"year":2014},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/polygenic-risk-for-alzheimer-s-disease-influences-precuneal-volume-in-29358118","doi":"10.1016/j.neurobiolaging.2017.12.022","journal":"Neurobiology of aging","n_participants":null,"pmid":"29358118","source_url":"https://pubmed.ncbi.nlm.nih.gov/29358118/","study_design":null,"title":"Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations","title_match":true,"year":2018},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/polygenic-scores-and-mendelian-randomization-identify-plasma-proteins-39108314","doi":"10.3389/fnins.2024.1404377","journal":"Frontiers in neuroscience","n_participants":17747,"pmid":"39108314","source_url":"https://pubmed.ncbi.nlm.nih.gov/39108314/","study_design":"meta-analysis","title":"Polygenic scores and Mendelian randomization identify plasma proteins causally implicated in Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/improving-the-utility-of-polygenic-risk-scores-as-a-biomarker-for-34209762","doi":"10.3390/cells10071627","journal":"Cells","n_participants":null,"pmid":"34209762","source_url":"https://pubmed.ncbi.nlm.nih.gov/34209762/","study_design":null,"title":"Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer's Disease","title_match":true,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/polygenic-risk-for-alzheimer-s-disease-is-associated-with-neuroaxonal-38213949","doi":"10.1002/dad2.12504","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"38213949","source_url":"https://pubmed.ncbi.nlm.nih.gov/38213949/","study_design":"cohort study","title":"Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms","title_match":true,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/genetic-underpinnings-of-sociability-in-the-general-population-34054130","doi":"10.1038/s41386-021-01044-z","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":342461,"pmid":"34054130","source_url":"https://pubmed.ncbi.nlm.nih.gov/34054130/","study_design":null,"title":"Genetic underpinnings of sociability in the general population","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/older-molecular-brain-age-in-severe-mental-illness-32632206","doi":"10.1038/s41380-020-0834-1","journal":"Molecular psychiatry","n_participants":null,"pmid":"32632206","source_url":"https://pubmed.ncbi.nlm.nih.gov/32632206/","study_design":null,"title":"Older molecular brain age in severe mental illness","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/investigating-the-genetic-characteristics-of-hippocampal-volume-and-35623891","doi":"10.1212/wnl.0000000000200554","journal":"Neurology","n_participants":1261,"pmid":"35623891","source_url":"https://pubmed.ncbi.nlm.nih.gov/35623891/","study_design":null,"title":"Investigating the Genetic Characteristics of Hippocampal Volume and Plasma \u03b2-Amyloid in a Chinese Community-Dwelling Population","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/effects-of-polygenic-risk-for-alzheimer-s-disease-on-rate-of-32709845","doi":"10.1038/s41398-020-00934-y","journal":"Translational psychiatry","n_participants":1087,"pmid":"32709845","source_url":"https://pubmed.ncbi.nlm.nih.gov/32709845/","study_design":"longitudinal study","title":"Effects of polygenic risk for Alzheimer's disease on rate of cognitive decline in normal aging","title_match":true,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/reprogramming-neurodegeneration-in-the-big-data-era-29331684","doi":"10.1016/j.conb.2017.12.015","journal":"Current opinion in neurobiology","n_participants":null,"pmid":"29331684","source_url":"https://pubmed.ncbi.nlm.nih.gov/29331684/","study_design":null,"title":"Reprogramming neurodegeneration in the big data era","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/bridging-the-gap-short-structural-variants-in-the-genetics-of-35470453","doi":"10.1002/eat.23716","journal":"The International journal of eating disorders","n_participants":null,"pmid":"35470453","source_url":"https://pubmed.ncbi.nlm.nih.gov/35470453/","study_design":null,"title":"Bridging the gap: Short structural variants in the genetics of anorexia nervosa","title_match":false,"year":2022},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cross-ancestry-polygenic-risk-scores-enhance-alzheimer-s-disease-risk-41282686","doi":"10.1101/2025.10.03.25337285","journal":"medRxiv : the preprint server for health sciences","n_participants":null,"pmid":"41282686","source_url":"https://pubmed.ncbi.nlm.nih.gov/41282686/","study_design":null,"title":"Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction in Multiethnic Cohorts","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/a-rare-missense-variant-of-casp7-is-associated-with-familial-late-30503768","doi":"10.1016/j.jalz.2018.10.005","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"30503768","source_url":"https://pubmed.ncbi.nlm.nih.gov/30503768/","study_design":"case-control study","title":"A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/genetic-background-for-alzheimer-s-disease-knowledge-accumulated-from-31588048","doi":"10.11477/mf.1416201403","journal":"Brain and nerve = Shinkei kenkyu no shinpo","n_participants":null,"pmid":"31588048","source_url":"https://pubmed.ncbi.nlm.nih.gov/31588048/","study_design":"meta-analysis","title":"[Genetic Background for Alzheimer's Disease: Knowledge Accumulated from AD GWAS]","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/shared-genetic-etiology-between-alzheimer-s-disease-and-blood-levels-34198788","doi":"10.3390/genes12060865","journal":"Genes","n_participants":null,"pmid":"34198788","source_url":"https://pubmed.ncbi.nlm.nih.gov/34198788/","study_design":null,"title":"Shared Genetic Etiology between Alzheimer's Disease and Blood Levels of Specific Cytokines and Growth Factors","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-rare-loss-of-function-variant-of-adam17-is-associated-with-late-29988083","doi":"10.1038/s41380-018-0091-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"29988083","source_url":"https://pubmed.ncbi.nlm.nih.gov/29988083/","study_design":null,"title":"A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease","title_match":true,"year":2020},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/shared-genetic-architecture-between-covid-19-severity-and-alzheimer-s-39764106","doi":"10.21203/rs.3.rs-5619229/v1","journal":"Research square","n_participants":null,"pmid":"39764106","source_url":"https://pubmed.ncbi.nlm.nih.gov/39764106/","study_design":null,"title":"Shared Genetic Architecture Between COVID-19 Severity and Alzheimer's Disease Across European and African Ancestries","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/translational-research-on-polygenic-risk-scores-in-common-39907297","doi":"10.5644/ama2006-124.463","journal":"Acta medica academica","n_participants":null,"pmid":"39907297","source_url":"https://pubmed.ncbi.nlm.nih.gov/39907297/","study_design":null,"title":"Translational Research on Polygenic Risk Scores in Common Neurodegenerative Diseases - A Scoping Review Protocol","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-s-disease-in-the-african-american-population-37629231","doi":"10.3390/jcm12165189","journal":"Journal of clinical medicine","n_participants":null,"pmid":"37629231","source_url":"https://pubmed.ncbi.nlm.nih.gov/37629231/","study_design":null,"title":"Genetics of Alzheimer's Disease in the African American Population","title_match":false,"year":2023},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/interplay-between-socioeconomic-markers-and-polygenic-predisposition-32187654","doi":"10.1111/jgs.16406","journal":"Journal of the American Geriatrics Society","n_participants":7039,"pmid":"32187654","source_url":"https://pubmed.ncbi.nlm.nih.gov/32187654/","study_design":"prospective cohort","title":"Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alzheimer-risk-increasing-trem2-variant-causes-aberrant-cortical-37591465","doi":"10.1016/j.nbd.2023.106263","journal":"Neurobiology of disease","n_participants":null,"pmid":"37591465","source_url":"https://pubmed.ncbi.nlm.nih.gov/37591465/","study_design":null,"title":"Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/triggering-receptor-expressed-on-myeloid-cells-2-is-involved-in-prion-25816748","doi":"10.1016/j.neurobiolaging.2015.02.019","journal":"Neurobiology of aging","n_participants":null,"pmid":"25816748","source_url":"https://pubmed.ncbi.nlm.nih.gov/25816748/","study_design":null,"title":"Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains","title_match":false,"year":2015},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/trem2-and-the-progression-of-alzheimer-s-disease-28393702","doi":"10.2174/1567202614666170404165201","journal":"Current neurovascular research","n_participants":null,"pmid":"28393702","source_url":"https://pubmed.ncbi.nlm.nih.gov/28393702/","study_design":null,"title":"TREM2 and the Progression of Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/triggering-receptor-expressed-on-myeloid-cells-2-variants-are-rare-in-24602511","doi":"10.1016/j.neurobiolaging.2014.01.142","journal":"Neurobiology of aging","n_participants":908,"pmid":"24602511","source_url":"https://pubmed.ncbi.nlm.nih.gov/24602511/","study_design":null,"title":"Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort","title_match":false,"year":2014},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/investigation-of-triggering-receptor-expressed-on-myeloid-cells-2-24378087","doi":"10.1016/j.neurobiolaging.2013.11.013","journal":"Neurobiology of aging","n_participants":1148,"pmid":"24378087","source_url":"https://pubmed.ncbi.nlm.nih.gov/24378087/","study_design":"longitudinal study","title":"Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/ship-inhibition-mediates-select-trem2-induced-microglial-functions-38613944","doi":"10.1016/j.molimm.2024.04.002","journal":"Molecular immunology","n_participants":null,"pmid":"38613944","source_url":"https://pubmed.ncbi.nlm.nih.gov/38613944/","study_design":null,"title":"SHIP inhibition mediates select TREM2-induced microglial functions","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/trem2-expression-in-the-brain-and-biological-fluids-in-prion-diseases-33881612","doi":"10.1007/s00401-021-02296-1","journal":"Acta neuropathologica","n_participants":null,"pmid":"33881612","source_url":"https://pubmed.ncbi.nlm.nih.gov/33881612/","study_design":null,"title":"TREM2 expression in the brain and biological fluids in prion diseases","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/trem2-mediates-microglial-anti-inflammatory-activations-in-alzheimer-33557250","doi":"10.3390/cells10020321","journal":"Cells","n_participants":null,"pmid":"33557250","source_url":"https://pubmed.ncbi.nlm.nih.gov/33557250/","study_design":null,"title":"TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/meprin-cleaves-trem2-and-controls-its-phagocytic-activity-on-32237095","doi":"10.1096/fj.201902183r","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"32237095","source_url":"https://pubmed.ncbi.nlm.nih.gov/32237095/","study_design":null,"title":"Meprin \u03b2 cleaves TREM2 and controls its phagocytic activity on macrophages","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/different-mechanisms-of-apolipoprotein-e-isoform-dependent-modulation-25593125","doi":"10.1096/fj.14-262683","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"25593125","source_url":"https://pubmed.ncbi.nlm.nih.gov/25593125/","study_design":null,"title":"Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/phagocytes-as-plaque-catalysts-human-macrophages-generate-seeding-41770935","doi":"10.1073/pnas.2516774123","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"41770935","source_url":"https://pubmed.ncbi.nlm.nih.gov/41770935/","study_design":null,"title":"Phagocytes as plaque catalysts: Human macrophages generate seeding-competent A\u03b242 fibrils with cross-seeding activity","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-and-risk-of-alzheimer-s-disease-time-to-move-forward-37274212","doi":"10.3389/fnins.2023.1195724","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"37274212","source_url":"https://pubmed.ncbi.nlm.nih.gov/37274212/","study_design":null,"title":"APOE\u03b54 and risk of Alzheimer's disease - time to move forward","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-emerging-roles-and-therapeutic-potential-of-soluble-trem2-in-32038221","doi":"10.3389/fnagi.2019.00328","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"32038221","source_url":"https://pubmed.ncbi.nlm.nih.gov/32038221/","study_design":null,"title":"The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/dian-dian-j-dian-tu-28739983","doi":"10.11477/mf.1416200811","journal":"Brain and nerve = Shinkei kenkyu no shinpo","n_participants":null,"pmid":"28739983","source_url":"https://pubmed.ncbi.nlm.nih.gov/28739983/","study_design":null,"title":"[DIAN/DIAN-J/DIAN-TU]","title_match":false,"year":2017},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-dian-study-24101429","doi":null,"journal":"Brain and nerve = Shinkei kenkyu no shinpo","n_participants":null,"pmid":"24101429","source_url":"https://pubmed.ncbi.nlm.nih.gov/24101429/","study_design":null,"title":"[The DIAN study]","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/spastic-paraplegia-preceding-psen1-related-familial-alzheimer-s-33969176","doi":"10.1002/dad2.12186","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"33969176","source_url":"https://pubmed.ncbi.nlm.nih.gov/33969176/","study_design":null,"title":"Spastic paraplegia preceding PSEN1-related familial Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/app-psen1-and-psen2-variants-in-alzheimer-s-disease-systematic-re-34220489","doi":"10.3389/fnagi.2021.695808","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"34220489","source_url":"https://pubmed.ncbi.nlm.nih.gov/34220489/","study_design":null,"title":"APP, PSEN1, and PSEN2 Variants in Alzheimer's Disease: Systematic Re-evaluation According to ACMG Guidelines","title_match":true,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-related-presenilins-are-key-to-intestinal-38684238","doi":"10.1136/gutjnl-2023-331622","journal":"Gut","n_participants":null,"pmid":"38684238","source_url":"https://pubmed.ncbi.nlm.nih.gov/38684238/","study_design":null,"title":"Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis","title_match":false,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-disease-sustained-by-presenilin-2-mutations-24594196","doi":"10.1016/j.neubiorev.2014.02.010","journal":"Neuroscience and biobehavioral reviews","n_participants":null,"pmid":"24594196","source_url":"https://pubmed.ncbi.nlm.nih.gov/24594196/","study_design":"systematic review","title":"Familial Alzheimer's disease sustained by presenilin 2 mutations: systematic review of literature and genotype-phenotype correlation","title_match":true,"year":2014},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/app-psen1-and-psen2-mutations-in-asian-patients-with-early-onset-31557888","doi":"10.3390/ijms20194757","journal":"International journal of molecular sciences","n_participants":32,"pmid":"31557888","source_url":"https://pubmed.ncbi.nlm.nih.gov/31557888/","study_design":null,"title":"APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease","title_match":true,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/targeting-secretase-for-familial-alzheimer-s-disease-35295247","doi":"10.1007/s00044-021-02744-3","journal":"Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents","n_participants":null,"pmid":"35295247","source_url":"https://pubmed.ncbi.nlm.nih.gov/35295247/","study_design":null,"title":"Targeting \u03b3-Secretase for Familial Alzheimer's Disease","title_match":true,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/early-onset-familial-alzheimer-disease-variant-psen2-n141i-32741831","doi":"10.3233/jad-200492","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"32741831","source_url":"https://pubmed.ncbi.nlm.nih.gov/32741831/","study_design":null,"title":"Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/presenilin-mutations-and-their-impact-on-neuronal-differentiation-in-34100423","doi":"10.4103/1673-5374.313016","journal":"Neural regeneration research","n_participants":null,"pmid":"34100423","source_url":"https://pubmed.ncbi.nlm.nih.gov/34100423/","study_design":null,"title":"Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-study-of-young-onset-dementia-using-targeted-gene-panel-33580635","doi":"10.1002/ajmg.b.32836","journal":"American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics","n_participants":52,"pmid":"33580635","source_url":"https://pubmed.ncbi.nlm.nih.gov/33580635/","study_design":null,"title":"Genetic study of young-onset dementia using targeted gene panel sequencing in Taiwan","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/early-onset-familial-alzheimer-s-disease-eofad-22728850","doi":"10.1017/s0317167100013949","journal":"The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques","n_participants":null,"pmid":"22728850","source_url":"https://pubmed.ncbi.nlm.nih.gov/22728850/","study_design":null,"title":"Early-onset familial Alzheimer's disease (EOFAD)","title_match":true,"year":2012},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/corticobasal-syndrome-in-a-family-with-early-onset-alzheimer-s-30838239","doi":"10.1002/mdc3.12212","journal":"Movement disorders clinical practice","n_participants":null,"pmid":"30838239","source_url":"https://pubmed.ncbi.nlm.nih.gov/30838239/","study_design":null,"title":"Corticobasal Syndrome in a Family with Early-Onset Alzheimer's Disease Linked to a Presenilin-1 Gene Mutation","title_match":true,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-novel-psen2-p-ser175phe-variant-in-a-family-with-alzheimer-s-disease-33855622","doi":"10.1007/s10072-021-05243-w","journal":"Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology","n_participants":null,"pmid":"33855622","source_url":"https://pubmed.ncbi.nlm.nih.gov/33855622/","study_design":null,"title":"A novel PSEN2 p.Ser175Phe variant in a family with Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/systematic-validation-of-variants-of-unknown-significance-in-app-32087291","doi":"10.1016/j.nbd.2020.104817","journal":"Neurobiology of disease","n_participants":null,"pmid":"32087291","source_url":"https://pubmed.ncbi.nlm.nih.gov/32087291/","study_design":null,"title":"Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2","title_match":true,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/disease-duration-in-autosomal-dominant-familial-alzheimer-disease-a-33225064","doi":"10.1212/nxg.0000000000000507","journal":"Neurology. Genetics","n_participants":null,"pmid":"33225064","source_url":"https://pubmed.ncbi.nlm.nih.gov/33225064/","study_design":null,"title":"Disease duration in autosomal dominant familial Alzheimer disease: A survival analysis","title_match":true,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mutation-profile-of-app-psen1-and-psen2-in-chinese-familial-alzheimer-30822634","doi":"10.1016/j.neurobiolaging.2019.01.018","journal":"Neurobiology of aging","n_participants":null,"pmid":"30822634","source_url":"https://pubmed.ncbi.nlm.nih.gov/30822634/","study_design":null,"title":"Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/psen1-and-psen2-gene-expression-in-alzheimer-s-disease-brain-a-new-24927704","doi":"10.3233/jad-140033","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"24927704","source_url":"https://pubmed.ncbi.nlm.nih.gov/24927704/","study_design":null,"title":"PSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach","title_match":true,"year":2014},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/genetics-of-early-onset-alzheimer-dementia-12847300","doi":"10.1100/tsw.2003.39","journal":"TheScientificWorldJournal","n_participants":null,"pmid":"12847300","source_url":"https://pubmed.ncbi.nlm.nih.gov/12847300/","study_design":null,"title":"Genetics of early-onset Alzheimer dementia","title_match":false,"year":2003},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/genetic-analyses-of-early-onset-alzheimer-s-disease-using-next-31182772","doi":"10.1038/s41598-019-44848-2","journal":"Scientific reports","n_participants":67,"pmid":"31182772","source_url":"https://pubmed.ncbi.nlm.nih.gov/31182772/","study_design":null,"title":"Genetic analyses of early-onset Alzheimer's disease using next generation sequencing","title_match":false,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/discovery-and-validation-of-autosomal-dominant-alzheimer-s-disease-30021643","doi":"10.1186/s13195-018-0392-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"30021643","source_url":"https://pubmed.ncbi.nlm.nih.gov/30021643/","study_design":null,"title":"Discovery and validation of autosomal dominant Alzheimer's disease mutations","title_match":true,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/genetic-screening-in-early-onset-alzheimer-s-disease-identified-three-30797548","doi":"10.1016/j.neurobiolaging.2019.01.015","journal":"Neurobiology of aging","n_participants":68,"pmid":"30797548","source_url":"https://pubmed.ncbi.nlm.nih.gov/30797548/","study_design":null,"title":"Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations","title_match":true,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/aberrant-splicing-of-psen2-but-not-psen1-in-individuals-with-sporadic-35949106","doi":"10.1093/brain/awac294","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"35949106","source_url":"https://pubmed.ncbi.nlm.nih.gov/35949106/","study_design":null,"title":"Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-disease-presenilin-2-mutants-affect-ca2-31606858","doi":"10.1007/s40520-019-01341-0","journal":"Aging clinical and experimental research","n_participants":null,"pmid":"31606858","source_url":"https://pubmed.ncbi.nlm.nih.gov/31606858/","study_design":null,"title":"Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability","title_match":true,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/psen2-thr421met-mutation-in-a-patient-with-early-onset-alzheimer-s-36362122","doi":"10.3390/ijms232113331","journal":"International journal of molecular sciences","n_participants":null,"pmid":"36362122","source_url":"https://pubmed.ncbi.nlm.nih.gov/36362122/","study_design":null,"title":"PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/switched-a43-generation-in-familial-alzheimer-s-disease-with-34728605","doi":"10.1038/s41398-021-01684-1","journal":"Translational psychiatry","n_participants":null,"pmid":"34728605","source_url":"https://pubmed.ncbi.nlm.nih.gov/34728605/","study_design":null,"title":"Switched A\u03b243 generation in familial Alzheimer's disease with presenilin 1 mutation","title_match":true,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/screening-for-genetic-mutations-associated-with-early-onset-alzheimer-36306459","doi":"10.2174/1567205020666221028112915","journal":"Current Alzheimer research","n_participants":34,"pmid":"36306459","source_url":"https://pubmed.ncbi.nlm.nih.gov/36306459/","study_design":null,"title":"Screening for Genetic Mutations Associated with Early-Onset Alzheimer's Disease in Han Chinese","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/in-search-of-pathogenic-amyloid-peptide-in-familial-alzheimer-s-31699328","doi":"10.1016/bs.pmbts.2019.07.002","journal":"Progress in molecular biology and translational science","n_participants":null,"pmid":"31699328","source_url":"https://pubmed.ncbi.nlm.nih.gov/31699328/","study_design":null,"title":"In search of pathogenic amyloid \u03b2-peptide in familial Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/metabolomic-and-lipidomic-signatures-in-autosomal-dominant-and-late-36251323","doi":"10.1002/alz.12800","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":133,"pmid":"36251323","source_url":"https://pubmed.ncbi.nlm.nih.gov/36251323/","study_design":null,"title":"Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/an-alternative-view-of-familial-alzheimer-s-disease-genetics-37718800","doi":"10.3233/jad-230313","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"37718800","source_url":"https://pubmed.ncbi.nlm.nih.gov/37718800/","study_design":null,"title":"An Alternative View of Familial Alzheimer's Disease Genetics","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/early-onset-familial-alzheimer-s-disease-in-a-family-with-mutation-of-33678657","doi":"10.11817/j.issn.1672-7347.2021.190616","journal":"Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences","n_participants":null,"pmid":"33678657","source_url":"https://pubmed.ncbi.nlm.nih.gov/33678657/","study_design":null,"title":"Early-onset familial Alzheimer's disease in a family with mutation of presenilin 2 gene","title_match":true,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/haploinsufficiency-and-alzheimer-s-disease-the-possible-pathogenic-39596030","doi":"10.3390/ijms252211959","journal":"International journal of molecular sciences","n_participants":null,"pmid":"39596030","source_url":"https://pubmed.ncbi.nlm.nih.gov/39596030/","study_design":null,"title":"Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/evidence-of-beta-amyloid-independent-small-vessel-disease-in-familial-35695802","doi":"10.1111/bpa.13097","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"35695802","source_url":"https://pubmed.ncbi.nlm.nih.gov/35695802/","study_design":null,"title":"Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/ipsc-derived-familial-alzheimer-s-psen2-n141i-cholinergic-neurons-29945658","doi":"10.1186/s13024-018-0265-5","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"29945658","source_url":"https://pubmed.ncbi.nlm.nih.gov/29945658/","study_design":null,"title":"iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling","title_match":true,"year":2018},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/presenilin-gene-mutation-associated-psychosis-phenotypic-38227890","doi":"10.1097/wad.0000000000000599","journal":"Alzheimer disease and associated disorders","n_participants":52,"pmid":"38227890","source_url":"https://pubmed.ncbi.nlm.nih.gov/38227890/","study_design":null,"title":"Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications","title_match":true,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/epileptic-seizures-in-autosomal-dominant-forms-of-alzheimer-s-disease-30041064","doi":"10.1016/j.seizure.2018.07.015","journal":"Seizure","n_participants":null,"pmid":"30041064","source_url":"https://pubmed.ncbi.nlm.nih.gov/30041064/","study_design":null,"title":"Epileptic seizures in autosomal dominant forms of Alzheimer's disease","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/presenilin-1-psen1-mutations-clinical-phenotypes-beyond-alzheimer-s-37176125","doi":"10.3390/ijms24098417","journal":"International journal of molecular sciences","n_participants":null,"pmid":"37176125","source_url":"https://pubmed.ncbi.nlm.nih.gov/37176125/","study_design":null,"title":"Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/integrative-multiomics-reveals-common-endotypes-across-psen1-psen2-39754192","doi":"10.1186/s13195-024-01659-6","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"39754192","source_url":"https://pubmed.ncbi.nlm.nih.gov/39754192/","study_design":null,"title":"Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/variable-expression-of-familial-alzheimer-disease-associated-with-10822446","doi":"10.1212/wnl.54.10.2006","journal":"Neurology","n_participants":null,"pmid":"10822446","source_url":"https://pubmed.ncbi.nlm.nih.gov/10822446/","study_design":null,"title":"Variable expression of familial Alzheimer disease associated with presenilin 2 mutation M239I","title_match":true,"year":2000},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/pathogenic-variants-in-the-longitudinal-early-onset-alzheimer-s-37801072","doi":"10.1002/alz.13482","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":299,"pmid":"37801072","source_url":"https://pubmed.ncbi.nlm.nih.gov/37801072/","study_design":"longitudinal study","title":"Pathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-genetically-modified-minipig-model-for-alzheimer-s-disease-with-36099918","doi":"10.1016/j.xcrm.2022.100740","journal":"Cell reports. Medicine","n_participants":null,"pmid":"36099918","source_url":"https://pubmed.ncbi.nlm.nih.gov/36099918/","study_design":null,"title":"A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/new-insights-into-the-molecular-bases-of-familial-alzheimer-s-disease-32325882","doi":"10.3390/jpm10020026","journal":"Journal of personalized medicine","n_participants":null,"pmid":"32325882","source_url":"https://pubmed.ncbi.nlm.nih.gov/32325882/","study_design":null,"title":"New Insights into the Molecular Bases of Familial Alzheimer's Disease","title_match":true,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-disease-mutations-in-presenilin-generate-27100199","doi":"10.1016/j.neuron.2016.03.010","journal":"Neuron","n_participants":null,"pmid":"27100199","source_url":"https://pubmed.ncbi.nlm.nih.gov/27100199/","study_design":null,"title":"Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic A\u03b2 Peptide Seeds","title_match":true,"year":2016},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/intracellular-calcium-dysregulation-by-the-alzheimer-s-disease-linked-31991578","doi":"10.3390/ijms21030770","journal":"International journal of molecular sciences","n_participants":null,"pmid":"31991578","source_url":"https://pubmed.ncbi.nlm.nih.gov/31991578/","study_design":null,"title":"Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2","title_match":true,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/relevance-of-a-truncated-presenilin-2-transcript-to-alzheimer-s-33720885","doi":"10.3233/jad-201133","journal":"Journal of Alzheimer's disease : JAD","n_participants":160,"pmid":"33720885","source_url":"https://pubmed.ncbi.nlm.nih.gov/33720885/","study_design":null,"title":"Relevance of a Truncated PRESENILIN 2 Transcript to Alzheimer's Disease and Neurodegeneration","title_match":true,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-genetics-of-alzheimer-s-disease-in-the-chinese-population-32235595","doi":"10.3390/ijms21072381","journal":"International journal of molecular sciences","n_participants":null,"pmid":"32235595","source_url":"https://pubmed.ncbi.nlm.nih.gov/32235595/","study_design":null,"title":"The Genetics of Alzheimer's Disease in the Chinese Population","title_match":false,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/from-est-to-structure-models-for-functional-inference-of-app-bace1-31831959","doi":"10.6026/97320630015760","journal":"Bioinformation","n_participants":null,"pmid":"31831959","source_url":"https://pubmed.ncbi.nlm.nih.gov/31831959/","study_design":null,"title":"From EST to structure models for functional inference of APP, BACE1, PSEN1, PSEN2 genes","title_match":true,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/mutational-analysis-in-early-onset-familial-alzheimer-s-disease-in-24650794","doi":"10.1016/j.neurobiolaging.2014.02.014","journal":"Neurobiology of aging","n_participants":32,"pmid":"24650794","source_url":"https://pubmed.ncbi.nlm.nih.gov/24650794/","study_design":null,"title":"Mutational analysis in early-onset familial Alzheimer's disease in Mainland China","title_match":true,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/early-onset-familial-alzheimer-s-disease-mutation-frequency-in-31-12552037","doi":"10.1212/01.wnl.0000042088.22694.e3","journal":"Neurology","n_participants":null,"pmid":"12552037","source_url":"https://pubmed.ncbi.nlm.nih.gov/12552037/","study_design":null,"title":"Early onset familial Alzheimer's disease: Mutation frequency in 31 families","title_match":true,"year":2003},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/clinical-and-neuroimaging-characterization-of-chinese-dementia-25323700","doi":"10.1159/000366272","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"25323700","source_url":"https://pubmed.ncbi.nlm.nih.gov/25323700/","study_design":null,"title":"Clinical and neuroimaging characterization of Chinese dementia patients with PSEN1 and PSEN2 mutations","title_match":true,"year":2015},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/microrna-profiling-in-aging-brain-of-psen1-psen2-double-knockout-mice-28879407","doi":"10.1007/s12035-017-0753-6","journal":"Molecular neurobiology","n_participants":null,"pmid":"28879407","source_url":"https://pubmed.ncbi.nlm.nih.gov/28879407/","study_design":null,"title":"MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/epigenetic-modifications-of-dna-and-rna-in-alzheimer-s-disease-38726308","doi":"10.3389/fnmol.2024.1398026","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"38726308","source_url":"https://pubmed.ncbi.nlm.nih.gov/38726308/","study_design":null,"title":"Epigenetic modifications of DNA and RNA in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/mutation-screening-in-chinese-patients-with-familial-alzheimer-s-30598257","doi":"10.1016/j.neurobiolaging.2018.11.024","journal":"Neurobiology of aging","n_participants":15,"pmid":"30598257","source_url":"https://pubmed.ncbi.nlm.nih.gov/30598257/","study_design":null,"title":"Mutation screening in Chinese patients with familial Alzheimer's disease by whole-exome sequencing","title_match":true,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/presenilin-1-regulates-membrane-homeostatic-pathways-that-are-32804090","doi":"10.3233/jad-200598","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"32804090","source_url":"https://pubmed.ncbi.nlm.nih.gov/32804090/","study_design":null,"title":"Presenilin 1 Regulates Membrane Homeostatic Pathways that are Dysregulated in Alzheimer's Disease","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/discovery-and-validation-of-dominantly-inherited-alzheimer-s-disease-35932032","doi":"10.1186/s13195-022-01052-1","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"35932032","source_url":"https://pubmed.ncbi.nlm.nih.gov/35932032/","study_design":null,"title":"Discovery and validation of dominantly inherited Alzheimer's disease mutations in populations from Latin America","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/rare-autosomal-copy-number-variations-in-early-onset-familial-23752245","doi":"10.1038/mp.2013.77","journal":"Molecular psychiatry","n_participants":null,"pmid":"23752245","source_url":"https://pubmed.ncbi.nlm.nih.gov/23752245/","study_design":null,"title":"Rare autosomal copy number variations in early-onset familial Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/familial-alzheimer-s-disease-mutations-in-psen1-lead-to-premature-33440141","doi":"10.1016/j.celrep.2020.108615","journal":"Cell reports","n_participants":null,"pmid":"33440141","source_url":"https://pubmed.ncbi.nlm.nih.gov/33440141/","study_design":null,"title":"Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis","title_match":true,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/identification-of-somatic-mutations-in-dementia-related-genes-in-33272183","doi":"10.2174/1567205017666201203124341","journal":"Current Alzheimer research","n_participants":null,"pmid":"33272183","source_url":"https://pubmed.ncbi.nlm.nih.gov/33272183/","study_design":null,"title":"Identification of Somatic Mutations in Dementia-related Genes in Cancer Patients","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/progressive-cognitive-impairment-and-familial-spastic-paraparesis-due-35438347","doi":"10.1007/s00415-022-11125-8","journal":"Journal of neurology","n_participants":null,"pmid":"35438347","source_url":"https://pubmed.ncbi.nlm.nih.gov/35438347/","study_design":null,"title":"Progressive cognitive impairment and familial spastic paraparesis due to PRESENILIN 1 mutation: anatomoclinical characterization","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/incomplete-penetrance-in-familial-alzheimer-s-disease-with-psen1-32328830","doi":"10.1007/s10072-020-04421-6","journal":"Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology","n_participants":null,"pmid":"32328830","source_url":"https://pubmed.ncbi.nlm.nih.gov/32328830/","study_design":null,"title":"Incomplete penetrance in familial Alzheimer's disease with PSEN1 Ala260Gly mutation","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/developing-a-gene-therapy-for-the-treatment-of-autosomal-dominant-37578141","doi":"10.1089/hum.2023.092","journal":"Human gene therapy","n_participants":null,"pmid":"37578141","source_url":"https://pubmed.ncbi.nlm.nih.gov/37578141/","study_design":null,"title":"Developing a Gene Therapy for the Treatment of Autosomal Dominant Alzheimer's Disease","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/psen1-g417s-mutation-in-a-chinese-pedigree-causing-early-onset-35489321","doi":"10.1016/j.neurobiolaging.2022.03.016","journal":"Neurobiology of aging","n_participants":null,"pmid":"35489321","source_url":"https://pubmed.ncbi.nlm.nih.gov/35489321/","study_design":null,"title":"PSEN1 G417S mutation in a Chinese pedigree causing early-onset parkinsonism with cognitive impairment","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/identification-of-psen2-mutation-p-n141i-in-argentine-pedigrees-with-26166204","doi":"10.1016/j.neurobiolaging.2015.06.011","journal":"Neurobiology of aging","n_participants":19,"pmid":"26166204","source_url":"https://pubmed.ncbi.nlm.nih.gov/26166204/","study_design":null,"title":"Identification of PSEN2 mutation p.N141I in Argentine pedigrees with early-onset familial Alzheimer's disease","title_match":true,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/identification-of-psen1-and-psen2-gene-mutations-and-variants-in-22503161","doi":"10.1016/j.neurobiolaging.2012.02.020","journal":"Neurobiology of aging","n_participants":null,"pmid":"22503161","source_url":"https://pubmed.ncbi.nlm.nih.gov/22503161/","study_design":"cohort study","title":"Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients","title_match":true,"year":2012},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/mutations-associated-with-early-onset-alzheimer-s-disease-discovered-27799753","doi":"10.2147/cia.s116218","journal":"Clinical interventions in aging","n_participants":null,"pmid":"27799753","source_url":"https://pubmed.ncbi.nlm.nih.gov/27799753/","study_design":null,"title":"Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries","title_match":false,"year":2016},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/rare-causes-of-early-onset-dystonia-parkinsonism-with-cognitive-28664294","doi":"10.1007/s10048-017-0518-4","journal":"Neurogenetics","n_participants":null,"pmid":"28664294","source_url":"https://pubmed.ncbi.nlm.nih.gov/28664294/","study_design":null,"title":"Rare causes of early-onset dystonia-parkinsonism with cognitive impairment: a de novo PSEN-1 mutation","title_match":false,"year":2017},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/significance-and-progress-of-dian-a4-api-27025079","doi":null,"journal":"Nihon rinsho. Japanese journal of clinical medicine","n_participants":null,"pmid":"27025079","source_url":"https://pubmed.ncbi.nlm.nih.gov/27025079/","study_design":null,"title":"[Significance and progress of DIAN/A4/API]","title_match":false,"year":2016},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/mechanisms-of-neurodegeneration-insights-from-familial-alzheimer-s-32418657","doi":"10.1016/j.semcdb.2020.03.005","journal":"Seminars in cell & developmental biology","n_participants":null,"pmid":"32418657","source_url":"https://pubmed.ncbi.nlm.nih.gov/32418657/","study_design":null,"title":"Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease","title_match":true,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/evaluating-pathogenicity-of-variants-of-unknown-significance-in-app-39875235","doi":"10.1016/j.neurot.2025.e00527","journal":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","n_participants":null,"pmid":"39875235","source_url":"https://pubmed.ncbi.nlm.nih.gov/39875235/","study_design":null,"title":"Evaluating pathogenicity of variants of unknown significance in APP, PSEN1, and PSEN2","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-possible-pathogenic-psen2-gly56ser-mutation-in-a-korean-patient-35328387","doi":"10.3390/ijms23062967","journal":"International journal of molecular sciences","n_participants":null,"pmid":"35328387","source_url":"https://pubmed.ncbi.nlm.nih.gov/35328387/","study_design":null,"title":"A Possible Pathogenic PSEN2 Gly56Ser Mutation in a Korean Patient with Early-Onset Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-novel-presenilin-2-gene-mutation-d439a-in-a-patient-with-early-11723295","doi":"10.1212/wnl.57.10.1926","journal":"Neurology","n_participants":null,"pmid":"11723295","source_url":"https://pubmed.ncbi.nlm.nih.gov/11723295/","study_design":null,"title":"A novel presenilin 2 gene mutation (D439A) in a patient with early-onset Alzheimer's disease","title_match":true,"year":2001},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-pathogenic-psen1-trp165cys-mutation-associated-with-early-onset-31391004","doi":"10.1186/s12883-019-1419-y","journal":"BMC neurology","n_participants":null,"pmid":"31391004","source_url":"https://pubmed.ncbi.nlm.nih.gov/31391004/","study_design":null,"title":"A pathogenic PSEN1 Trp165Cys mutation associated with early-onset Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/comprehensive-screening-for-disease-risk-variants-in-early-onset-28106563","doi":"10.3233/jad-161185","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28106563","source_url":"https://pubmed.ncbi.nlm.nih.gov/28106563/","study_design":null,"title":"Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants","title_match":false,"year":2017},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-pathogenic-psen2-p-his169asn-mutation-associated-with-early-onset-30104866","doi":"10.2147/cia.s170374","journal":"Clinical interventions in aging","n_participants":null,"pmid":"30104866","source_url":"https://pubmed.ncbi.nlm.nih.gov/30104866/","study_design":null,"title":"A pathogenic PSEN2 p.His169Asn mutation associated with early-onset Alzheimer's disease","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genetic-and-epigenetic-targets-of-natural-dietary-compounds-as-anti-37843220","doi":"10.4103/1673-5374.382232","journal":"Neural regeneration research","n_participants":null,"pmid":"37843220","source_url":"https://pubmed.ncbi.nlm.nih.gov/37843220/","study_design":null,"title":"Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/presence-of-alzheimer-s-disease-variants-in-circular-rna-of-psen1-and-40518825","doi":"10.1177/13872877251350112","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"40518825","source_url":"https://pubmed.ncbi.nlm.nih.gov/40518825/","study_design":null,"title":"Presence of Alzheimer's disease variants in circular RNA of PSEN1 and PSEN2","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/hereditary-dementia-with-intracerebral-hemorrhages-and-cerebral-15277614","doi":"10.1212/01.wnl.0000129988.68657.fa","journal":"Neurology","n_participants":null,"pmid":"15277614","source_url":"https://pubmed.ncbi.nlm.nih.gov/15277614/","study_design":null,"title":"Hereditary dementia with intracerebral hemorrhages and cerebral amyloid angiopathy","title_match":false,"year":2004},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cortical-neurodegeneration-caused-by-psen1-mutations-is-independent-39136994","doi":"10.1073/pnas.2409343121","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"39136994","source_url":"https://pubmed.ncbi.nlm.nih.gov/39136994/","study_design":null,"title":"Cortical neurodegeneration caused by Psen1 mutations is independent of A\u03b2","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/presenilin-1-and-app-gene-mutations-in-early-onset-ad-families-from-a-32579498","doi":"10.2174/1567205017666200624195809","journal":"Current Alzheimer research","n_participants":67,"pmid":"32579498","source_url":"https://pubmed.ncbi.nlm.nih.gov/32579498/","study_design":null,"title":"Presenilin 1 and APP Gene Mutations in Early-Onset AD Families from a Southeast Region of China","title_match":true,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/brain-somatic-mutations-in-alzheimer-s-disease-linking-genetic-41068782","doi":"10.1186/s13024-025-00895-0","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"41068782","source_url":"https://pubmed.ncbi.nlm.nih.gov/41068782/","study_design":null,"title":"Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/variability-in-the-type-and-layer-distribution-of-cortical-a-34319632","doi":"10.1111/bpa.13009","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"34319632","source_url":"https://pubmed.ncbi.nlm.nih.gov/34319632/","study_design":null,"title":"Variability in the type and layer distribution of cortical A\u03b2 pathology in familial Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/autosomal-dominantly-inherited-alzheimer-disease-analysis-of-genetic-32284705","doi":"10.1016/j.inffus.2020.01.001","journal":"An international journal on information fusion","n_participants":null,"pmid":"32284705","source_url":"https://pubmed.ncbi.nlm.nih.gov/32284705/","study_design":"longitudinal study","title":"Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/noncognitive-species-typical-and-home-cage-behavioral-alterations-in-34758364","doi":"10.1016/j.bbr.2021.113652","journal":"Behavioural brain research","n_participants":null,"pmid":"34758364","source_url":"https://pubmed.ncbi.nlm.nih.gov/34758364/","study_design":null,"title":"Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice","title_match":true,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/what-is-early-onset-dementia-19604328","doi":"10.1111/j.1479-8301.2009.00274.x","journal":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","n_participants":null,"pmid":"19604328","source_url":"https://pubmed.ncbi.nlm.nih.gov/19604328/","study_design":null,"title":"What is 'early onset dementia'?","title_match":false,"year":2009},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-novel-psen1-mutation-i238m-associated-with-early-onset-alzheimer-s-24413619","doi":"10.3233/jad-131844","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"24413619","source_url":"https://pubmed.ncbi.nlm.nih.gov/24413619/","study_design":null,"title":"A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman","title_match":true,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/contribution-of-homozygous-and-compound-heterozygous-missense-33023779","doi":"10.1016/j.neurobiolaging.2020.09.009","journal":"Neurobiology of aging","n_participants":1148,"pmid":"33023779","source_url":"https://pubmed.ncbi.nlm.nih.gov/33023779/","study_design":null,"title":"Contribution of homozygous and compound heterozygous missense mutations in VWA2 to Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/lysosome-and-calcium-dysregulation-in-alzheimer-s-disease-partners-in-24256243","doi":"10.1042/bst20130201","journal":"Biochemical Society transactions","n_participants":null,"pmid":"24256243","source_url":"https://pubmed.ncbi.nlm.nih.gov/24256243/","study_design":null,"title":"Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime","title_match":false,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/early-onset-familial-alzheimer-s-disease-with-spastic-paraparesis-37994898","doi":"10.17116/jnevro2023123111120","journal":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","n_participants":null,"pmid":"37994898","source_url":"https://pubmed.ncbi.nlm.nih.gov/37994898/","study_design":null,"title":"[Early-onset familial Alzheimer's disease with spastic paraparesis associated with PSEN1 gene]","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/presenilin-1-mutation-likely-contributes-to-u1-small-nuclear-rna-33450722","doi":"10.1016/j.neurobiolaging.2020.12.015","journal":"Neurobiology of aging","n_participants":null,"pmid":"33450722","source_url":"https://pubmed.ncbi.nlm.nih.gov/33450722/","study_design":null,"title":"Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease-like symptoms","title_match":true,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/very-early-onset-ad-with-a-de-novo-mutation-in-the-presenilin-1-gene-14581682","doi":"10.1212/01.wnl.0000086811.39675.79","journal":"Neurology","n_participants":null,"pmid":"14581682","source_url":"https://pubmed.ncbi.nlm.nih.gov/14581682/","study_design":null,"title":"Very early onset AD with a de novo mutation in the presenilin 1 gene (Met 233 Leu)","title_match":true,"year":2003},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/orchestration-of-genetic-alterations-in-psen1-and-psen2-genes-in-38213663","doi":"10.1055/s-0043-1777849","journal":"Global medical genetics","n_participants":null,"pmid":"38213663","source_url":"https://pubmed.ncbi.nlm.nih.gov/38213663/","study_design":null,"title":"Orchestration of Genetic Alterations in PSEN1 and PSEN2 Genes in Development of Alzheimer's Disease through Computational Analysis","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/role-of-neurotoxicants-in-the-pathogenesis-of-alzheimer-s-disease-a-34433343","doi":"10.1080/07853890.2021.1966088","journal":"Annals of medicine","n_participants":null,"pmid":"34433343","source_url":"https://pubmed.ncbi.nlm.nih.gov/34433343/","study_design":null,"title":"Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/novel-psen1-and-pgrn-mutations-in-early-onset-familial-frontotemporal-18314228","doi":"10.1016/j.neurobiolaging.2008.01.005","journal":"Neurobiology of aging","n_participants":17,"pmid":"18314228","source_url":"https://pubmed.ncbi.nlm.nih.gov/18314228/","study_design":null,"title":"Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia","title_match":true,"year":2009},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/human-brain-vascular-multi-omics-elucidates-disease-risk-associations-40730185","doi":"10.1016/j.neuron.2025.07.001","journal":"Neuron","n_participants":null,"pmid":"40730185","source_url":"https://pubmed.ncbi.nlm.nih.gov/40730185/","study_design":null,"title":"Human brain vascular multi-omics elucidates disease-risk associations","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/spatial-and-single-nucleus-transcriptomic-analysis-of-genetic-and-39578645","doi":"10.1038/s41588-024-01961-x","journal":"Nature genetics","n_participants":null,"pmid":"39578645","source_url":"https://pubmed.ncbi.nlm.nih.gov/39578645/","study_design":null,"title":"Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/single-nucleus-multiomics-identifies-zeb1-and-mafb-as-candidate-36950385","doi":"10.1016/j.xgen.2023.100263","journal":"Cell genomics","n_participants":null,"pmid":"36950385","source_url":"https://pubmed.ncbi.nlm.nih.gov/36950385/","study_design":null,"title":"Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific cis-regulatory elements","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/single-nucleus-rna-sequencing-demonstrates-an-autosomal-dominant-38417436","doi":"10.1016/j.neuron.2024.02.009","journal":"Neuron","n_participants":null,"pmid":"38417436","source_url":"https://pubmed.ncbi.nlm.nih.gov/38417436/","study_design":null,"title":"Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer's disease profile and possible mechanisms of disease protection","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/molecular-hallmarks-of-excitatory-and-inhibitory-neuronal-resilience-41035073","doi":"10.1186/s13024-025-00892-3","journal":"Molecular neurodegeneration","n_participants":631,"pmid":"41035073","source_url":"https://pubmed.ncbi.nlm.nih.gov/41035073/","study_design":null,"title":"Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/epigenome-wide-analyses-identify-dna-methylation-signatures-of-32789163","doi":"10.1002/dad2.12078","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"32789163","source_url":"https://pubmed.ncbi.nlm.nih.gov/32789163/","study_design":null,"title":"Epigenome-wide analyses identify DNA methylation signatures of dementia risk","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/methylation-differences-in-alzheimer-s-disease-neuropathologic-change-36447297","doi":"10.1186/s40478-022-01470-0","journal":"Acta neuropathologica communications","n_participants":47,"pmid":"36447297","source_url":"https://pubmed.ncbi.nlm.nih.gov/36447297/","study_design":null,"title":"Methylation differences in Alzheimer's disease neuropathologic change in the aged human brain","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/multi-omic-blood-biomarkers-as-dynamic-risk-predictors-in-late-onset-38279230","doi":"10.3390/ijms25021231","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38279230","source_url":"https://pubmed.ncbi.nlm.nih.gov/38279230/","study_design":null,"title":"Multi-Omic Blood Biomarkers as Dynamic Risk Predictors in Late-Onset Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/multi-omic-atlas-of-the-parahippocampal-gyrus-in-alzheimer-s-disease-37684260","doi":"10.1038/s41597-023-02507-2","journal":"Scientific data","n_participants":null,"pmid":"37684260","source_url":"https://pubmed.ncbi.nlm.nih.gov/37684260/","study_design":null,"title":"Multi-omic atlas of the parahippocampal gyrus in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/characterizing-dysregulations-via-cell-cell-communications-in-38741048","doi":"10.1186/s12868-024-00867-y","journal":"BMC neuroscience","n_participants":null,"pmid":"38741048","source_url":"https://pubmed.ncbi.nlm.nih.gov/38741048/","study_design":null,"title":"Characterizing dysregulations via cell-cell communications in Alzheimer's brains using single-cell transcriptomes","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/tau-accumulation-in-autosomal-dominant-alzheimer-s-disease-a-37231491","doi":"10.1186/s13195-023-01234-5","journal":"Alzheimer's research & therapy","n_participants":59,"pmid":"37231491","source_url":"https://pubmed.ncbi.nlm.nih.gov/37231491/","study_design":"cohort study","title":"Tau accumulation in autosomal dominant Alzheimer's disease: a longitudinal [18F]flortaucipir study","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-tracers-binding-sites-in-autosomal-dominant-and-sporadic-27693181","doi":"10.1016/j.jalz.2016.08.006","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"27693181","source_url":"https://pubmed.ncbi.nlm.nih.gov/27693181/","study_design":null,"title":"Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease","title_match":true,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/apoe4-potentiates-the-relationship-between-amyloid-and-tau-pathologies-32161362","doi":"10.1038/s41380-020-0688-6","journal":"Molecular psychiatry","n_participants":211,"pmid":"32161362","source_url":"https://pubmed.ncbi.nlm.nih.gov/32161362/","study_design":null,"title":"APOE\u03b54 potentiates the relationship between amyloid-\u03b2 and tau pathologies","title_match":false,"year":2021},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/chinese-preclinical-alzheimer-s-disease-study-c-pas-design-and-37357299","doi":"10.14283/jpad.2023.49","journal":"The journal of prevention of Alzheimer's disease","n_participants":4386,"pmid":"37357299","source_url":"https://pubmed.ncbi.nlm.nih.gov/37357299/","study_design":"longitudinal study","title":"Chinese Preclinical Alzheimer's Disease Study (C-PAS): Design and Challenge from PET Acceptance","title_match":false,"year":2023},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/modeling-autosomal-dominant-alzheimer-s-disease-with-machine-learning-33480178","doi":"10.1002/alz.12259","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"33480178","source_url":"https://pubmed.ncbi.nlm.nih.gov/33480178/","study_design":"longitudinal study","title":"Modeling autosomal dominant Alzheimer's disease with machine learning","title_match":true,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/default-mode-network-connectivity-in-alzheimers-disease-32594490","doi":null,"journal":"Turk psikiyatri dergisi = Turkish journal of psychiatry","n_participants":null,"pmid":"32594490","source_url":"https://pubmed.ncbi.nlm.nih.gov/32594490/","study_design":null,"title":"Default Mode Network Connectivity in Alzheimers Disease","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/early-detection-of-dementia-with-default-mode-network-effective-41716754","doi":"10.1038/s44220-024-00259-5","journal":"Nature. Mental health","n_participants":null,"pmid":"41716754","source_url":"https://pubmed.ncbi.nlm.nih.gov/41716754/","study_design":"case-control study","title":"Early detection of dementia with default-mode network effective connectivity","title_match":false,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/structural-and-functional-brain-connectivity-in-presymptomatic-25002573","doi":"10.1212/wnl.0000000000000583","journal":"Neurology","n_participants":39,"pmid":"25002573","source_url":"https://pubmed.ncbi.nlm.nih.gov/25002573/","study_design":"case-control study","title":"Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia","title_match":true,"year":2014},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/eye-brain-connections-revealed-by-multimodal-retinal-and-brain-39025851","doi":"10.1038/s41467-024-50309-w","journal":"Nature communications","n_participants":null,"pmid":"39025851","source_url":"https://pubmed.ncbi.nlm.nih.gov/39025851/","study_design":null,"title":"Eye-brain connections revealed by multimodal retinal and brain imaging genetics","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/past-present-and-future-role-of-retinal-imaging-in-neurodegenerative-33460813","doi":"10.1016/j.preteyeres.2020.100938","journal":"Progress in retinal and eye research","n_participants":null,"pmid":"33460813","source_url":"https://pubmed.ncbi.nlm.nih.gov/33460813/","study_design":null,"title":"Past, present and future role of retinal imaging in neurodegenerative disease","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/retinal-imaging-in-animal-models-searching-for-biomarkers-of-38983000","doi":"10.3389/fopht.2023.1156605","journal":"Frontiers in ophthalmology","n_participants":null,"pmid":"38983000","source_url":"https://pubmed.ncbi.nlm.nih.gov/38983000/","study_design":null,"title":"Retinal imaging in animal models: Searching for biomarkers of neurodegeneration","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-potential-of-solanezumab-and-gantenerumab-to-prevent-alzheimer-s-29037101","doi":"10.1080/14712598.2018.1389885","journal":"Expert opinion on biological therapy","n_participants":null,"pmid":"29037101","source_url":"https://pubmed.ncbi.nlm.nih.gov/29037101/","study_design":null,"title":"The potential of solanezumab and gantenerumab to prevent Alzheimer's disease in people with inherited mutations that cause its early onset","title_match":true,"year":2018},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/safety-and-efficacy-of-long-term-gantenerumab-treatment-in-dominantly-40120616","doi":"10.1016/s1474-4422(25)00024-9","journal":"The Lancet. Neurology","n_participants":53,"pmid":"40120616","source_url":"https://pubmed.ncbi.nlm.nih.gov/40120616/","study_design":"clinical trial","title":"Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/identifying-genetic-risk-for-amyloid-related-imaging-abnormalities-38165303","doi":"10.1212/wnl.0000000000208096","journal":"Neurology","n_participants":null,"pmid":"38165303","source_url":"https://pubmed.ncbi.nlm.nih.gov/38165303/","study_design":null,"title":"Identifying Genetic Risk for Amyloid-Related Imaging Abnormalities","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/can-anti-amyloid-monoclonal-antibodies-work-in-autosomal-dominant-33575481","doi":"10.1212/nxg.0000000000000535","journal":"Neurology. Genetics","n_participants":144,"pmid":"33575481","source_url":"https://pubmed.ncbi.nlm.nih.gov/33575481/","study_design":null,"title":"Can Anti-\u03b2-amyloid Monoclonal Antibodies Work in Autosomal Dominant Alzheimer Disease?","title_match":true,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/from-bench-to-bedside-cutting-edge-and-emerging-therapies-for-40993929","doi":"10.2174/0118715249388723250910140541","journal":"Central nervous system agents in medicinal chemistry","n_participants":null,"pmid":"40993929","source_url":"https://pubmed.ncbi.nlm.nih.gov/40993929/","study_design":null,"title":"From Bench to Bedside: Cutting-Edge and Emerging Therapies for Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-predicts-pathologically-confirmed-cerebral-41383049","doi":"10.1002/alz.70958","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41383049","source_url":"https://pubmed.ncbi.nlm.nih.gov/41383049/","study_design":null,"title":"Polygenic risk score predicts pathologically confirmed cerebral amyloid angiopathy","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/targeting-tau-to-treat-clinical-features-of-huntington-s-disease-33329322","doi":"10.3389/fneur.2020.580732","journal":"Frontiers in neurology","n_participants":null,"pmid":"33329322","source_url":"https://pubmed.ncbi.nlm.nih.gov/33329322/","study_design":null,"title":"Targeting Tau to Treat Clinical Features of Huntington's Disease","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/asos-are-an-effective-treatment-for-disease-associated-38429929","doi":"10.1016/j.ymthe.2024.02.033","journal":"Molecular therapy : the journal of the American Society of Gene Therapy","n_participants":null,"pmid":"38429929","source_url":"https://pubmed.ncbi.nlm.nih.gov/38429929/","study_design":null,"title":"ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/metformin-mitigates-trimethyltin-induced-cognition-impairment-and-39441380","doi":"10.1007/s10571-024-01502-4","journal":"Cellular and molecular neurobiology","n_participants":null,"pmid":"39441380","source_url":"https://pubmed.ncbi.nlm.nih.gov/39441380/","study_design":null,"title":"Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Neurodegeneration","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/ambroxol-as-a-disease-modifying-treatment-to-reduce-the-risk-of-38027469","doi":"10.1136/bmjno-2023-000535","journal":"BMJ neurology open","n_participants":null,"pmid":"38027469","source_url":"https://pubmed.ncbi.nlm.nih.gov/38027469/","study_design":"open-label trial","title":"Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment in GBA-associated Parkinson's disease: a multicentre, randomised, double-blind, placebo-controlled, phase II trial. The AMBITIOUS study protocol","title_match":false,"year":2023},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/huntington-s-disease-drug-development-a-phase-3-pipeline-analysis-38004378","doi":"10.3390/ph16111513","journal":"Pharmaceuticals (Basel, Switzerland)","n_participants":null,"pmid":"38004378","source_url":"https://pubmed.ncbi.nlm.nih.gov/38004378/","study_design":"systematic review","title":"Huntington's Disease Drug Development: A Phase 3 Pipeline Analysis","title_match":false,"year":2023},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/polygenicity-and-apoe-4-shape-response-to-intervention-in-mild-41388319","doi":"10.1186/s13195-025-01907-3","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"41388319","source_url":"https://pubmed.ncbi.nlm.nih.gov/41388319/","study_design":null,"title":"Polygenicity and APOE \u03b54 shape response to intervention in mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/sorting-out-the-role-of-the-sortilin-related-receptor-1-in-alzheimer-32587946","doi":"10.3233/adr-200177","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"32587946","source_url":"https://pubmed.ncbi.nlm.nih.gov/32587946/","study_design":null,"title":"Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/aerobic-exercise-improves-hippocampal-blood-flow-for-hypertensive-33509035","doi":"10.1177/0271678x21990342","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":44,"pmid":"33509035","source_url":"https://pubmed.ncbi.nlm.nih.gov/33509035/","study_design":null,"title":"Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/lrrk2-alpha-synuclein-and-tau-partners-in-crime-or-unfortunate-31085616","doi":"10.1042/bst20180466","journal":"Biochemical Society transactions","n_participants":null,"pmid":"31085616","source_url":"https://pubmed.ncbi.nlm.nih.gov/31085616/","study_design":null,"title":"LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?","title_match":false,"year":2019},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genetic-risk-score-and-neuroimaging-in-the-finger-38647197","doi":"10.1002/alz.13843","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":126,"pmid":"38647197","source_url":"https://pubmed.ncbi.nlm.nih.gov/38647197/","study_design":null,"title":"Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial","title_match":true,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/protocol-of-aerobic-exercise-and-cognitive-health-reach-a-pilot-study-32587945","doi":"10.3233/adr-200180","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"32587945","source_url":"https://pubmed.ncbi.nlm.nih.gov/32587945/","study_design":null,"title":"Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/sleep-and-dementia-37676320","doi":"10.1007/s00391-023-02237-5","journal":"Zeitschrift fur Gerontologie und Geriatrie","n_participants":null,"pmid":"37676320","source_url":"https://pubmed.ncbi.nlm.nih.gov/37676320/","study_design":null,"title":"[Sleep and dementia]","title_match":false,"year":2023},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/longitudinal-association-of-apolipoprotein-e-and-sleep-with-incident-34477303","doi":"10.1002/alz.12439","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34477303","source_url":"https://pubmed.ncbi.nlm.nih.gov/34477303/","study_design":"longitudinal study","title":"Longitudinal association of apolipoprotein E and sleep with incident dementia","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/sleep-and-circadian-abnormalities-precede-cognitive-deficits-in-r521c-30273830","doi":"10.1016/j.neurobiolaging.2018.08.025","journal":"Neurobiology of aging","n_participants":null,"pmid":"30273830","source_url":"https://pubmed.ncbi.nlm.nih.gov/30273830/","study_design":null,"title":"Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats","title_match":false,"year":2018},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/association-of-genetic-risk-for-alzheimer-disease-and-hearing-32878991","doi":"10.1212/wnl.0000000000010709","journal":"Neurology","n_participants":80074,"pmid":"32878991","source_url":"https://pubmed.ncbi.nlm.nih.gov/32878991/","study_design":null,"title":"Association of genetic risk for Alzheimer disease and hearing impairment","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/role-of-diet-and-exercise-in-aging-alzheimer-s-disease-and-other-37832608","doi":"10.1016/j.arr.2023.102091","journal":"Ageing research reviews","n_participants":null,"pmid":"37832608","source_url":"https://pubmed.ncbi.nlm.nih.gov/37832608/","study_design":null,"title":"Role of diet and exercise in aging, Alzheimer's disease, and other chronic diseases","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/metabolic-syndrome-24796101","doi":null,"journal":"Nihon rinsho. Japanese journal of clinical medicine","n_participants":null,"pmid":"24796101","source_url":"https://pubmed.ncbi.nlm.nih.gov/24796101/","study_design":null,"title":"[Metabolic syndrome]","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/influence-of-genetic-and-cardiometabolic-risk-factors-in-alzheimer-s-36038112","doi":"10.1016/j.arr.2022.101723","journal":"Ageing research reviews","n_participants":null,"pmid":"36038112","source_url":"https://pubmed.ncbi.nlm.nih.gov/36038112/","study_design":null,"title":"Influence of genetic and cardiometabolic risk factors in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/association-of-cardiovascular-risk-factors-with-cerebral-perfusion-in-32310160","doi":"10.3233/jad-190360","journal":"Journal of Alzheimer's disease : JAD","n_participants":330,"pmid":"32310160","source_url":"https://pubmed.ncbi.nlm.nih.gov/32310160/","study_design":null,"title":"Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans","title_match":false,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-in-patients-with-cardiovascular-risk-decog-study-33863650","doi":"10.1016/j.semerg.2021.01.009","journal":"Semergen","n_participants":458,"pmid":"33863650","source_url":"https://pubmed.ncbi.nlm.nih.gov/33863650/","study_design":"cross-sectional","title":"[Cognitive impairment in patients with cardiovascular risk: DECOG study]","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/education-and-genetic-risk-modulate-hippocampal-structure-in-27699079","doi":"10.14336/ad.2016.0305","journal":"Aging and disease","n_participants":null,"pmid":"27699079","source_url":"https://pubmed.ncbi.nlm.nih.gov/27699079/","study_design":null,"title":"Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease","title_match":true,"year":2016},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/educational-attainment-and-sex-modulate-clinical-outcomes-in-genetic-42553777","doi":"10.1093/braincomms/fcag262","journal":"Brain communications","n_participants":711,"pmid":"42553777","source_url":"https://pubmed.ncbi.nlm.nih.gov/42553777/","study_design":null,"title":"Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/regional-tau-pathology-and-loneliness-in-cognitively-normal-older-30563962","doi":"10.1038/s41398-018-0345-x","journal":"Translational psychiatry","n_participants":null,"pmid":"30563962","source_url":"https://pubmed.ncbi.nlm.nih.gov/30563962/","study_design":null,"title":"Regional tau pathology and loneliness in cognitively normal older adults","title_match":false,"year":2018},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/associations-of-air-pollution-and-genetic-risk-with-incident-dementia-36269005","doi":"10.1093/aje/kwac188","journal":"American journal of epidemiology","n_participants":227840,"pmid":"36269005","source_url":"https://pubmed.ncbi.nlm.nih.gov/36269005/","study_design":"cohort study","title":"Associations of Air Pollution and Genetic Risk With Incident Dementia: A Prospective Cohort Study","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/ozone-and-particulate-matter-exposure-and-alzheimer-s-disease-a-32568209","doi":"10.3233/jad-200435","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"32568209","source_url":"https://pubmed.ncbi.nlm.nih.gov/32568209/","study_design":null,"title":"Ozone and Particulate Matter Exposure and Alzheimer's Disease: A Review of Human and Animal Studies","title_match":false,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/tlr4-cross-talk-with-nlrp3-inflammasome-and-complement-signaling-32391019","doi":"10.3389/fimmu.2020.00724","journal":"Frontiers in immunology","n_participants":null,"pmid":"32391019","source_url":"https://pubmed.ncbi.nlm.nih.gov/32391019/","study_design":null,"title":"TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/magnesium-l-threonate-treats-alzheimer-s-disease-by-modulating-the-38488562","doi":"10.4103/1673-5374.391310","journal":"Neural regeneration research","n_participants":null,"pmid":"38488562","source_url":"https://pubmed.ncbi.nlm.nih.gov/38488562/","study_design":null,"title":"Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/gut-derived-amyloid-likely-a-centerpiece-of-the-gut-brain-axis-36683147","doi":"10.1080/19490976.2023.2167172","journal":"Gut microbes","n_participants":null,"pmid":"36683147","source_url":"https://pubmed.ncbi.nlm.nih.gov/36683147/","study_design":null,"title":"Gut-derived \u03b2-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/diet-gut-microbiome-and-cognitive-decline-36018501","doi":"10.1007/s13668-022-00435-y","journal":"Current nutrition reports","n_participants":null,"pmid":"36018501","source_url":"https://pubmed.ncbi.nlm.nih.gov/36018501/","study_design":null,"title":"Diet, Gut Microbiome, and Cognitive Decline","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/fecal-microbiota-transplantation-a-microbiome-modulation-technique-34430117","doi":"10.7759/cureus.16503","journal":"Cureus","n_participants":null,"pmid":"34430117","source_url":"https://pubmed.ncbi.nlm.nih.gov/34430117/","study_design":null,"title":"Fecal Microbiota Transplantation: A Microbiome Modulation Technique for Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/clinical-considerations-in-early-onset-cerebral-amyloid-angiopathy-37280119","doi":"10.1093/brain/awad193","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"37280119","source_url":"https://pubmed.ncbi.nlm.nih.gov/37280119/","study_design":null,"title":"Clinical considerations in early-onset cerebral amyloid angiopathy","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/endothelial-cells-as-key-players-in-cerebral-small-vessel-disease-39743557","doi":"10.1038/s41583-024-00892-0","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"39743557","source_url":"https://pubmed.ncbi.nlm.nih.gov/39743557/","study_design":null,"title":"Endothelial cells as key players in cerebral small vessel disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/monogenic-causes-of-cerebral-small-vessel-disease-and-stroke-39322384","doi":"10.1016/b978-0-323-99209-1.00018-1","journal":"Handbook of clinical neurology","n_participants":null,"pmid":"39322384","source_url":"https://pubmed.ncbi.nlm.nih.gov/39322384/","study_design":null,"title":"Monogenic causes of cerebral small vessel disease and stroke","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/effects-of-cerebral-amyloid-angiopathy-on-the-brain-vasculome-35851991","doi":"10.1111/acel.13503","journal":"Aging cell","n_participants":null,"pmid":"35851991","source_url":"https://pubmed.ncbi.nlm.nih.gov/35851991/","study_design":null,"title":"Effects of cerebral amyloid angiopathy on the brain vasculome","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/leaky-memories-impact-of-apoe4-on-blood-brain-barrier-and-dementia-32600092","doi":"10.1177/0271678x20938146","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"32600092","source_url":"https://pubmed.ncbi.nlm.nih.gov/32600092/","study_design":null,"title":"Leaky memories: Impact of APOE4 on blood-brain barrier and dementia","title_match":false,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/endothelial-mitochondrial-dysfunction-in-cerebral-amyloid-angiopathy-31306129","doi":"10.3233/jad-190357","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31306129","source_url":"https://pubmed.ncbi.nlm.nih.gov/31306129/","study_design":null,"title":"Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/attenuated-csf-1r-signalling-drives-cerebrovascular-pathology-33350588","doi":"10.15252/emmm.202012889","journal":"EMBO molecular medicine","n_participants":null,"pmid":"33350588","source_url":"https://pubmed.ncbi.nlm.nih.gov/33350588/","study_design":null,"title":"Attenuated CSF-1R signalling drives cerebrovascular pathology","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-pericyte-a-critical-cell-in-the-pathogenesis-of-cadasil-34950895","doi":"10.1016/j.cccb.2021.100031","journal":"Cerebral circulation - cognition and behavior","n_participants":null,"pmid":"34950895","source_url":"https://pubmed.ncbi.nlm.nih.gov/34950895/","study_design":null,"title":"The pericyte: A critical cell in the pathogenesis of CADASIL","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/experimental-rodent-models-of-vascular-dementia-a-systematic-review-33423653","doi":"10.2174/1871527319666210108123438","journal":"CNS & neurological disorders drug targets","n_participants":null,"pmid":"33423653","source_url":"https://pubmed.ncbi.nlm.nih.gov/33423653/","study_design":null,"title":"Experimental Rodent Models of Vascular Dementia: A Systematic Review","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/older-adults-with-reduced-cerebrovascular-reactivity-exhibit-high-38579393","doi":"10.1016/j.neurobiolaging.2024.03.006","journal":"Neurobiology of aging","n_participants":125,"pmid":"38579393","source_url":"https://pubmed.ncbi.nlm.nih.gov/38579393/","study_design":null,"title":"Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cerebral-small-vessel-disease-at-high-altitude-a-comparison-of-36970535","doi":"10.3389/fneur.2023.1086476","journal":"Frontiers in neurology","n_participants":169,"pmid":"36970535","source_url":"https://pubmed.ncbi.nlm.nih.gov/36970535/","study_design":null,"title":"Cerebral small-vessel disease at high altitude: A comparison of patients from plateau and plain","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/limbic-predominant-age-related-tdp43-encephalopathy-late-37563264","doi":"10.1038/s41582-023-00846-7","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"37563264","source_url":"https://pubmed.ncbi.nlm.nih.gov/37563264/","study_design":null,"title":"Limbic-predominant age-related TDP43 encephalopathy (LATE) neuropathological change in neurodegenerative diseases","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/primary-tau-pathology-not-copathology-correlates-with-clinical-31999351","doi":"10.1093/jnen/nlz141","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"31999351","source_url":"https://pubmed.ncbi.nlm.nih.gov/31999351/","study_design":null,"title":"Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/pink1-deficiency-permits-the-development-of-lewy-body-dementia-with-40990068","doi":"10.1002/alz.70730","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40990068","source_url":"https://pubmed.ncbi.nlm.nih.gov/40990068/","study_design":null,"title":"PINK1 deficiency permits the development of Lewy body dementia with coexisting A\u03b2 pathology","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/synuclein-mediated-neurodegeneration-in-dementia-with-lewy-bodies-the-34798911","doi":"10.1186/s13578-021-00709-y","journal":"Cell & bioscience","n_participants":null,"pmid":"34798911","source_url":"https://pubmed.ncbi.nlm.nih.gov/34798911/","study_design":null,"title":"\u03b1-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox","title_match":false,"year":2021},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/distinct-characteristics-of-limbic-predominant-age-related-tdp-43-34854996","doi":"10.1007/s00401-021-02383-3","journal":"Acta neuropathologica","n_participants":313,"pmid":"34854996","source_url":"https://pubmed.ncbi.nlm.nih.gov/34854996/","study_design":null,"title":"Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/a-refined-concept-synuclein-dysregulation-disease-29305061","doi":"10.1016/j.neuint.2017.12.011","journal":"Neurochemistry international","n_participants":null,"pmid":"29305061","source_url":"https://pubmed.ncbi.nlm.nih.gov/29305061/","study_design":null,"title":"A refined concept: \u03b1-synuclein dysregulation disease","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/synuclein-seed-amplification-assay-detects-lewy-body-co-pathology-in-38666355","doi":"10.1002/alz.13818","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":26,"pmid":"38666355","source_url":"https://pubmed.ncbi.nlm.nih.gov/38666355/","study_design":null,"title":"\u03b1-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/altered-expression-of-presenilin2-impacts-endolysosomal-homeostasis-39613768","doi":"10.1038/s41467-024-54777-y","journal":"Nature communications","n_participants":null,"pmid":"39613768","source_url":"https://pubmed.ncbi.nlm.nih.gov/39613768/","study_design":null,"title":"Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/modified-glutamatergic-postsynapse-in-neurodegenerative-disorders-31887357","doi":"10.1016/j.neuroscience.2019.12.002","journal":"Neuroscience","n_participants":null,"pmid":"31887357","source_url":"https://pubmed.ncbi.nlm.nih.gov/31887357/","study_design":null,"title":"Modified Glutamatergic Postsynapse in Neurodegenerative Disorders","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-apoe-receptors-and-the-synapse-in-alzheimer-s-disease-28057414","doi":"10.1016/j.tem.2016.12.001","journal":"Trends in endocrinology and metabolism: TEM","n_participants":null,"pmid":"28057414","source_url":"https://pubmed.ncbi.nlm.nih.gov/28057414/","study_design":null,"title":"ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/presenilins-regulate-synaptic-plasticity-in-the-perforant-pathways-of-36710361","doi":"10.1186/s13041-023-01009-x","journal":"Molecular brain","n_participants":null,"pmid":"36710361","source_url":"https://pubmed.ncbi.nlm.nih.gov/36710361/","study_design":null,"title":"Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-like-behavior-and-synaptic-dysfunction-in-3-tg-ad-mice-are-38719948","doi":"10.1007/s00221-024-06841-8","journal":"Experimental brain research","n_participants":null,"pmid":"38719948","source_url":"https://pubmed.ncbi.nlm.nih.gov/38719948/","study_design":null,"title":"Alzheimer-like behavior and synaptic dysfunction in 3 \u00d7 Tg-AD mice are reversed with calcineurin inhibition","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/differences-in-synaptic-dysfunction-between-rtg4510-and-app-ps1-mouse-29154272","doi":"10.3233/jad-170457","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29154272","source_url":"https://pubmed.ncbi.nlm.nih.gov/29154272/","study_design":null,"title":"Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-role-of-genetic-risk-factors-of-alzheimer-s-disease-in-synaptic-35918217","doi":"10.1016/j.semcdb.2022.07.011","journal":"Seminars in cell & developmental biology","n_participants":null,"pmid":"35918217","source_url":"https://pubmed.ncbi.nlm.nih.gov/35918217/","study_design":null,"title":"The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurotrophic-treatment-initiated-during-early-postnatal-development-34057082","doi":"10.3233/jad-201599","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34057082","source_url":"https://pubmed.ncbi.nlm.nih.gov/34057082/","study_design":null,"title":"Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/presenilins-and-secretase-in-membrane-proteostasis-30823664","doi":"10.3390/cells8030209","journal":"Cells","n_participants":null,"pmid":"30823664","source_url":"https://pubmed.ncbi.nlm.nih.gov/30823664/","study_design":null,"title":"Presenilins and \u03b3-Secretase in Membrane Proteostasis","title_match":false,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-ubiquitin-system-in-alzheimer-s-disease-32274758","doi":"10.1007/978-3-030-38266-7_8","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"32274758","source_url":"https://pubmed.ncbi.nlm.nih.gov/32274758/","study_design":null,"title":"The Ubiquitin System in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/erbb2-regulates-autophagic-flux-to-modulate-the-proteostasis-of-app-28351972","doi":"10.1073/pnas.1618804114","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"28351972","source_url":"https://pubmed.ncbi.nlm.nih.gov/28351972/","study_design":null,"title":"ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/ubiquitin-proteasome-system-in-the-different-stages-of-dominantly-39108475","doi":"10.21203/rs.3.rs-4202125/v1","journal":"Research square","n_participants":null,"pmid":"39108475","source_url":"https://pubmed.ncbi.nlm.nih.gov/39108475/","study_design":null,"title":"Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/person-specific-differences-in-ubiquitin-proteasome-mediated-38470006","doi":"10.1002/alz.13680","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38470006","source_url":"https://pubmed.ncbi.nlm.nih.gov/38470006/","study_design":null,"title":"Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/smpd3-deficiency-perturbs-neuronal-proteostasis-and-causes-29725009","doi":"10.1038/s41419-018-0560-7","journal":"Cell death & disease","n_participants":null,"pmid":"29725009","source_url":"https://pubmed.ncbi.nlm.nih.gov/29725009/","study_design":null,"title":"SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/trpmls-and-tpcs-targets-for-lysosomal-storage-and-neurodegenerative-35144097","doi":"10.1016/j.ceca.2022.102553","journal":"Cell calcium","n_participants":null,"pmid":"35144097","source_url":"https://pubmed.ncbi.nlm.nih.gov/35144097/","study_design":null,"title":"TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?","title_match":false,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/genetic-and-proteomic-analysis-identifies-bag3-as-an-amyloid-41085772","doi":"10.1007/s00401-025-02947-7","journal":"Acta neuropathologica","n_participants":null,"pmid":"41085772","source_url":"https://pubmed.ncbi.nlm.nih.gov/41085772/","study_design":null,"title":"Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/fighting-the-cause-of-alzheimer-s-and-gne-myopathy-30374284","doi":"10.3389/fnins.2018.00669","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"30374284","source_url":"https://pubmed.ncbi.nlm.nih.gov/30374284/","study_design":null,"title":"Fighting the Cause of Alzheimer's and GNE Myopathy","title_match":false,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/reality-of-family-caregiving-for-hispanics-with-alzheimer-s-disease-37311202","doi":"10.1089/jpm.2023.0008","journal":"Journal of palliative medicine","n_participants":null,"pmid":"37311202","source_url":"https://pubmed.ncbi.nlm.nih.gov/37311202/","study_design":null,"title":"Reality of Family Caregiving for Hispanics With Alzheimer's Disease and Related Dementias: A Qualitative Analysis","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/improving-genetic-risk-modeling-of-dementia-from-real-world-data-in-39183196","doi":"10.1038/s42003-024-06742-0","journal":"Communications biology","n_participants":610,"pmid":"39183196","source_url":"https://pubmed.ncbi.nlm.nih.gov/39183196/","study_design":null,"title":"Improving genetic risk modeling of dementia from real-world data in underrepresented populations","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/association-of-genetic-scores-related-to-insulin-resistance-with-40993182","doi":"10.1038/s42003-025-08674-9","journal":"Communications biology","n_participants":null,"pmid":"40993182","source_url":"https://pubmed.ncbi.nlm.nih.gov/40993182/","study_design":"cross-sectional","title":"Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/using-policy-to-improve-access-to-care-for-persons-with-alzheimer-s-31755537","doi":"10.3928/00989134-20191023-01","journal":"Journal of gerontological nursing","n_participants":null,"pmid":"31755537","source_url":"https://pubmed.ncbi.nlm.nih.gov/31755537/","study_design":null,"title":"Using Policy to Improve Access to Care for Persons With Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/associations-of-genetic-predisposition-to-alzheimers-disease-with-a6466441","doi":"10.21203/rs.3.rs-11220681/v1","journal":"Research Square","n_participants":3947,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11220681/v1","study_design":null,"title":"Associations of genetic predisposition to Alzheimer\u2019s disease with blood-based biomarkers: a community-based study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-synuclein-seed-amplification-assay-positivity-0d68a0e1","doi":"10.64898/2026.10.23.26366349","journal":"medRxiv","n_participants":248,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.23.26366349","study_design":"longitudinal study","title":"Cerebrospinal fluid \u03b1-synuclein seed amplification assay positivity identifies a prognostically distinct subgroup in amyotrophic lateral sclerosis","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-profiles-in-a-colombian-cohort-of-heterozygous-apoe3-6c38e2c0","doi":"10.21203/rs.3.rs-10705602/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10705602/v1","study_design":"cross-sectional","title":"Plasma Biomarker Profiles in a Colombian Cohort of Heterozygous APOE3-Christchurch Carriers","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-architecture-of-alzheimers-disease-related-plasma-biomarkers-5f0d801a","doi":"10.64898/2025.12.17.25342458","journal":"medRxiv","n_participants":696,"pmid":null,"source_url":"https://doi.org/10.64898/2025.12.17.25342458","study_design":null,"title":"Genetic architecture of Alzheimer\u2019s disease-related plasma biomarkers","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/proteomic-biomarkers-of-cognitive-function-apoe-4-status-and-dementia-2d2f572b","doi":"10.64898/2026.01.27.26344912","journal":"medRxiv","n_participants":14258,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.27.26344912","study_design":null,"title":"Proteomic biomarkers of cognitive function, APOE \u03b54 status, and dementia in Generation Scotland","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/regional-choroid-plexus-calcifications-and-their-associations-with-9cae63ba","doi":"10.64898/2026.09.10.750525","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.10.750525","study_design":null,"title":"Regional choroid plexus calcifications and their associations with aging, brain structure, and disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe4-and-psychosis-in-neurodegenerative-and-non-neurodegenerative-1d706ebb","doi":"10.20944/preprints202610.2617.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202610.2617.v1","study_design":null,"title":"ApoE4 and Psychosis in Neurodegenerative and Non-Neurodegenerative Disease: A Scoping Review","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/reproductive-aging-fsh-and-apolipoprotein-biology-in-alzheimers-afc592dc","doi":"10.20944/preprints202604.0104.v4","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202604.0104.v4","study_design":null,"title":"Reproductive Aging, FSH, and Apolipoprotein Biology in Alzheimer\u2019s Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/mapping-polygenic-risk-scores-to-brain-cells-insights-for-b706ae9d","doi":"10.64898/2026.10.08.26365054","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.08.26365054","study_design":null,"title":"Mapping polygenic risk scores to brain cells: insights for neurodegenerative diseases","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-family-aware-all-of-us-benchmark-for-polygenic-prediction-and-fa292dde","doi":"10.64898/2026.10.22.26366229","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.22.26366229","study_design":null,"title":"A family-aware All of Us benchmark for polygenic prediction and genomic machine learning","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/disease-specific-perturbational-convergence-between-genetic-risk-and-682e61e2","doi":"10.21203/rs.3.rs-11315638/v1","journal":"Research Square","n_participants":3202,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11315638/v1","study_design":null,"title":"Disease-Specific Perturbational Convergence Between Genetic-Risk and Disease-State Transcriptomic Signatures in Alzheimer's Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/regional-similarity-to-male-typical-brain-architecture-links-3c867269","doi":"10.64898/2026.09.27.754764","journal":"bioRxiv","n_participants":522,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.27.754764","study_design":null,"title":"Regional similarity to male-typical brain architecture links childhood ADHD to neurophysiological aging in later adulthood","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/large-scale-genome-wide-association-study-identified-shared-genetic-b1e4c121","doi":"10.21203/rs.3.rs-10960127/v1","journal":"Research Square","n_participants":803,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10960127/v1","study_design":null,"title":"Large-Scale Genome-wide association study identified Shared Genetic Risk SNPs Correlates in Epilepsy and Alzheimer's Disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-self-limiting-trem2-dependent-anabolic-program-confers-microglial-703e2eb0","doi":"10.64898/2026.09.16.752098","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.16.752098","study_design":null,"title":"A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/pregnancy-history-and-loss-of-normal-psen2-function-impact-female-7e17688f","doi":"10.64898/2026.10.28.762624","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.28.762624","study_design":null,"title":"Pregnancy History and Loss of Normal PSEN2 Function Impact Female Late-Life Cognitive Processing, Inhibitory Signaling, and Gliosis","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/temporal-proteomics-links-the-app-london-mutation-to-early-3abeafdf","doi":"10.64898/2026.10.20.760505","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.20.760505","study_design":"longitudinal study","title":"Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/endothelial-cd36-links-arteriolar-remodeling-to-metabolic-and-immune-ed611fa0","doi":"10.64898/2026.10.13.758947","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.13.758947","study_design":null,"title":"Endothelial CD36 links arteriolar remodeling to metabolic and immune alterations in Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-effects-of-arf4-gene-knockdown-on-alzheimer-s-amyloid-deposition-4e8ac976","doi":"10.21203/rs.3.rs-11040037/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11040037/v1","study_design":null,"title":"The effects of Arf4 gene knockdown on Alzheimer's amyloid \u03b2 deposition: Possible role in cognitive resilience","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/closed-head-injury-produces-a-delayed-region-specific-defect-in-2631138c","doi":"10.64898/2026.09.29.755475","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.29.755475","study_design":null,"title":"Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-lifespan-single-cell-atlas-of-the-human-developing-hippocampus-322c5c1f","doi":"10.64898/2026.09.18.752796","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.18.752796","study_design":null,"title":"A lifespan single-cell atlas of the human developing hippocampus benchmarks familial Alzheimer\u2019s disease brain organoids","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/parental-dementia-history-is-associated-with-peripheral-immune-aging-7596643f","doi":"10.64898/2026.10.22.26366051","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.22.26366051","study_design":null,"title":"Parental Dementia History is Associated with Peripheral Immune Aging Rather than Generalized Biological and Brain Age Acceleration in Midlife","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/csf-complement-proteins-are-associated-with-early-tau-pathology-and-84f8f39d","doi":"10.64898/2026.08.24.742564","journal":"bioRxiv","n_participants":708,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.24.742564","study_design":null,"title":"CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/network-level-functional-connectivity-is-associated-with-longitudinal-8250ae3c","doi":"10.21203/rs.3.rs-10282950/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10282950/v1","study_design":"longitudinal study","title":"Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/current-gaps-in-downstream-applications-of-fmri-foundation-models-51eea5af","doi":"10.64898/2026.10.22.26366227","journal":"medRxiv","n_participants":343,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.22.26366227","study_design":null,"title":"Current gaps in downstream applications of fMRI foundation models: lessons learned from BrainLM & BrainHarmonix on Prevent-AD","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/divergent-amyloid-trajectories-distinguish-normal-aging-from-20e069b5","doi":"10.64898/2026.09.08.748727","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.08.748727","study_design":"longitudinal study","title":"Divergent amyloid trajectories distinguish normal aging from Alzheimer's disease progression","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/multivariate-blood-biomarkers-capture-resilience-and-resistance-0f2be5f0","doi":"10.64898/2026.08.03.26359415","journal":"medRxiv","n_participants":1009,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.03.26359415","study_design":null,"title":"Multivariate blood biomarkers capture resilience and resistance phenotypes across the Alzheimer\u2019s disease spectrum","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/biomarker-variability-limits-individualized-amyloid-time-estimation-d4682f47","doi":"10.64898/2026.07.08.737258","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.08.737258","study_design":null,"title":"Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe-4-carrier-status-and-cognitive-decline-in-mild-to-moderate-8aa9046f","doi":"10.64898/2026.09.27.26364131","journal":"medRxiv","n_participants":370,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.27.26364131","study_design":"clinical trial","title":"APOE \u03b54 Carrier Status and Cognitive Decline in Mild-to-Moderate Alzheimer\u2019s Disease: A Linear Mixed-Effects Analysis of the Placebo Arm of EXPEDITION 1","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/trustpgs-when-can-a-polygenic-score-be-trusted-a-per-individual-45a812c1","doi":"10.64898/2026.07.01.735762","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.01.735762","study_design":null,"title":"TrustPGS: When can a polygenic score be trusted? A per-individual reliability framework across ancestries","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/age-related-speech-in-noise-hearing-loss-in-parkinsons-disease-and-a3ec8995","doi":"10.64898/2026.06.08.26355175","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.06.08.26355175","study_design":"longitudinal study","title":"Age-Related Speech-in-Noise Hearing Loss in Parkinson\u2019s Disease and APOE E4 Carriers","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/sequence-based-variant-effect-predictions-reveal-trait-specific-519cfcee","doi":"10.64898/2026.10.16.26365786","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.16.26365786","study_design":null,"title":"Sequence-based variant-effect predictions reveal trait-specific regulatory-layer profiles of complex-trait heritability","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/biopsychosocial-risk-factors-for-alzheimers-disease-and-related-a9a32f32","doi":"10.64898/2026.05.08.26352762","journal":"medRxiv","n_participants":3552,"pmid":null,"source_url":"https://doi.org/10.64898/2026.05.08.26352762","study_design":null,"title":"Biopsychosocial risk factors for Alzheimer\u2019s disease and related dementias in UK immigrants from the Middle East and North Africa (MENA)","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/associations-of-lifestyle-factors-and-genetic-risk-with-risk-and-rate-dc6dfca0","doi":"10.31234/osf.io/9tsj3_v1","journal":"PsyArXiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.31234/osf.io/9tsj3_v1","study_design":null,"title":"Associations of lifestyle factors and genetic risk with risk and rate advancement periods of dementia","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-effects-of-nicotine-on-neurocognitive-outcomes-evidence-from-a-c10227f5","doi":"10.64898/2025.11.27.25341175","journal":"medRxiv","n_participants":334757,"pmid":null,"source_url":"https://doi.org/10.64898/2025.11.27.25341175","study_design":"cohort study","title":"The effects of nicotine on neurocognitive outcomes: evidence from a polygenic risk score analysis","title_match":true,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/evidence-that-the-perinatal-maternal-microbiome-mediates-metabolite-847bc61d","doi":"10.21203/rs.3.rs-11307065/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11307065/v1","study_design":null,"title":"Evidence that the perinatal maternal microbiome mediates metabolite signaling programs that drive sex-specific microglial metabolic alterations and Alzheimer\u2019s disease susceptibility","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe4-reduction-in-vascular-associated-fibroblasts-decreases-cerebral-e9af705a","doi":"10.64898/2026.10.02.756327","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.02.756327","study_design":null,"title":"APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/reduced-phosphatases-and-hyperphosphorylated-glutamatergic-receptors-c51e2b7b","doi":"10.64898/2026.10.14.751571","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.14.751571","study_design":null,"title":"Reduced phosphatases and hyperphosphorylated glutamatergic receptors persist from early to late stages of prion disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/ion-modulation-restores-local-synaptic-function-in-apoe4-neuronal-816ff7e2","doi":"10.64898/2026.09.08.750089","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.08.750089","study_design":null,"title":"Ion modulation restores local synaptic function in APOE4 neuronal networks despite persistent impairments in global network organization","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/an-integrative-multimodal-model-for-early-diagnosis-of-dementia-and-984b6c78","doi":"10.64898/2026.07.31.26359317","journal":"medRxiv","n_participants":1100,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.31.26359317","study_design":null,"title":"An Integrative Multimodal Model for Early Diagnosis of Dementia and Differential Diagnosis of Alzheimer\u2019s Disease Using Neuroimaging, Polygenic Risk, and Cognitive Assessments","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-ywhag-nptx2-ratio-predicts-clinical-severity-and-4579e717","doi":"10.64898/2026.08.22.746470","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.22.746470","study_design":null,"title":"Cerebrospinal fluid YWHAG:NPTX2 ratio predicts clinical severity and future phenoconversion in frontotemporal lobar degeneration","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/trisomy-21-cerebral-organoids-exhibit-alzheimers-disease-amyloid-and-c6cd8c6a","doi":"10.64898/2026.07.01.735908","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.01.735908","study_design":null,"title":"Trisomy 21 cerebral organoids exhibit Alzheimer\u2019s disease amyloid and apolipoprotein E co-pathologies","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-dosage-normalization-rescues-neurogenesis-c5fbe4fa","doi":"10.1101/2025.07.30.667706","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1101/2025.07.30.667706","study_design":null,"title":"Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer\u2019s Disease phenotypes associated with Down Syndrome","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/selective-vulnerability-of-human-basal-forebrain-subsystems-in-ageing-bec5f4b9","doi":"10.64898/2026.10.13.26365385","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.13.26365385","study_design":"cross-sectional","title":"Selective vulnerability of human basal forebrain subsystems in ageing and neuropsychiatric disorders","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/parkinsons-disease-onset-in-light-of-acquired-irreversible-piezo2-22979f3e","doi":"10.20944/preprints202609.1965.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202609.1965.v1","study_design":null,"title":"Parkinson\u2019s Disease Onset in Light of Acquired Irreversible Piezo2 Channelopathy","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/progressive-behavioral-and-cognitive-decline-in-drosophila-harboring-bb67e0bb","doi":"10.64898/2026.09.08.750261","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.08.750261","study_design":null,"title":"Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/proteomic-signatures-of-apoe-4-across-human-tissues-and-cell-types-in-04732701","doi":"10.64898/2026.08.27.746928","journal":"bioRxiv","n_participants":1691,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.27.746928","study_design":null,"title":"Proteomic signatures of APOE \u03b54 across human tissues and cell types in Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-association-of-thrombophilic-and-cardiovascular-genetic-593f07c9","doi":"10.20944/preprints202608.2252.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202608.2252.v1","study_design":null,"title":"The Association of Thrombophilic and Cardiovascular Genetic Variations with Neurovascular and Neurodegenerative Diseases: A Multivariate Genetic and Clinical Analysis","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-prognostic-value-of-genetic-architectures-in-cognitive-decline-7bdbbe05","doi":"10.64898/2026.07.13.26357971","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.13.26357971","study_design":null,"title":"The Prognostic Value of Genetic Architectures in Cognitive Decline","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/longitudinal-cognitive-and-biomarker-changes-in-dominantly-inherited-30217935","doi":"10.1212/wnl.0000000000006277","journal":"Neurology","n_participants":null,"pmid":"30217935","source_url":"https://pubmed.ncbi.nlm.nih.gov/30217935/","study_design":"cross-sectional","title":"Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/idebenone-treatment-in-friedreich-patients-one-year-long-randomized-12771264","doi":"10.1212/01.wnl.0000055872.50364.fc","journal":"Neurology","n_participants":null,"pmid":"12771264","source_url":"https://pubmed.ncbi.nlm.nih.gov/12771264/","study_design":null,"title":"Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial","title_match":false,"year":2003},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/aberrant-ipsc-derived-human-astrocytes-in-alzheimer-s-disease-28333144","doi":"10.1038/cddis.2017.89","journal":"Cell Death and Disease","n_participants":null,"pmid":"28333144","source_url":"https://pubmed.ncbi.nlm.nih.gov/28333144/","study_design":null,"title":"Aberrant iPSC-derived human astrocytes in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-deposition-and-inflammation-in-appswe-ps1de9-mouse-model-of-19747158","doi":"10.2174/156720509790147070","journal":"Current Alzheimer Research","n_participants":null,"pmid":"19747158","source_url":"https://pubmed.ncbi.nlm.nih.gov/19747158/","study_design":null,"title":"Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease","title_match":false,"year":2009},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-4-and-cerebral-hemorrhage-associated-with-amyloid-7654074","doi":"10.1002/ana.410380219","journal":"Annals of Neurology","n_participants":15,"pmid":"7654074","source_url":"https://pubmed.ncbi.nlm.nih.gov/7654074/","study_design":null,"title":"Apolipoprotein E \u03f54 and cerebral hemorrhage associated with amyloid angiopathy","title_match":false,"year":1995},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/declining-brain-activity-in-cognitively-normal-apolipoprotein-e-4-11248079","doi":"10.1073/pnas.061509598","journal":"Proceedings of the National Academy of Sciences","n_participants":null,"pmid":"11248079","source_url":"https://pubmed.ncbi.nlm.nih.gov/11248079/","study_design":"cross-sectional","title":"Declining brain activity in cognitively normal apolipoprotein E \u025b4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease","title_match":false,"year":2001},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/microglia-drive-apoe-dependent-neurodegeneration-in-a-tauopathy-mouse-31601677","doi":"10.1084/jem.20190980","journal":"The Journal of Experimental Medicine","n_participants":null,"pmid":"31601677","source_url":"https://pubmed.ncbi.nlm.nih.gov/31601677/","study_design":null,"title":"Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/heritability-enrichment-of-specifically-expressed-genes-identifies-29632380","doi":"10.1038/s41588-018-0081-4","journal":"Nature Genetics","n_participants":null,"pmid":"29632380","source_url":"https://pubmed.ncbi.nlm.nih.gov/29632380/","study_design":null,"title":"Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types","title_match":true,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/association-of-gwaslinked-loci-with-lateonset-alzheimer-s-disease-in-23232270","doi":"10.1016/j.jalz.2012.08.007","journal":"Alzheimer s & Dementia","n_participants":1224,"pmid":"23232270","source_url":"https://pubmed.ncbi.nlm.nih.gov/23232270/","study_design":null,"title":"Association of GWAS\u2010linked loci with late\u2010onset Alzheimer's disease in a northern Han Chinese population","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/phenome-wide-analysis-of-genome-wide-polygenic-scores-26303664","doi":"10.1038/mp.2015.126","journal":"Molecular Psychiatry","n_participants":50,"pmid":"26303664","source_url":"https://pubmed.ncbi.nlm.nih.gov/26303664/","study_design":null,"title":"Phenome-wide analysis of genome-wide polygenic scores","title_match":true,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/human-longevity-is-influenced-by-many-genetic-variants-evidence-from-27015805","doi":"10.18632/aging.100930","journal":"Aging","n_participants":75244,"pmid":"27015805","source_url":"https://pubmed.ncbi.nlm.nih.gov/27015805/","study_design":null,"title":"Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-familial-alzheimer-s-disease-locus-on-chromosome-1-7638621","doi":"10.1126/science.7638621","journal":"Science","n_participants":null,"pmid":"7638621","source_url":"https://pubmed.ncbi.nlm.nih.gov/7638621/","study_design":null,"title":"A Familial Alzheimer's Disease Locus on Chromosome 1","title_match":true,"year":1995},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/p1146-chlamydia-pneumoniaeinfected-astrocytes-alter-their-expression-51ba2d77","doi":"10.1016/j.jalz.2016.06.894","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.jalz.2016.06.894","study_design":null,"title":"P1\u2010146: Chlamydia Pneumoniae\u2010Infected Astrocytes Alter Their Expression of Adam10, Bace1, and Presenilin\u20101 Proteases","title_match":true,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/pink1-and-parkin-mediated-mitophagy-at-a-glance-22448035","doi":"10.1242/jcs.093849","journal":"Journal of Cell Science","n_participants":null,"pmid":"22448035","source_url":"https://pubmed.ncbi.nlm.nih.gov/22448035/","study_design":null,"title":"PINK1- and Parkin-mediated mitophagy at a glance","title_match":false,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/synuclein-membrane-interactions-and-lipid-specificity-10915790","doi":"10.1074/jbc.m004345200","journal":"Journal of Biological Chemistry","n_participants":null,"pmid":"10915790","source_url":"https://pubmed.ncbi.nlm.nih.gov/10915790/","study_design":null,"title":"\u03b1-Synuclein Membrane Interactions and Lipid Specificity","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/modeling-familial-alzheimer-s-disease-with-induced-pluripotent-stem-21900357","doi":"10.1093/hmg/ddr394","journal":"Human Molecular Genetics","n_participants":null,"pmid":"21900357","source_url":"https://pubmed.ncbi.nlm.nih.gov/21900357/","study_design":null,"title":"Modeling familial Alzheimer's disease with induced pluripotent stem cells","title_match":true,"year":2011},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/self-organizing-3d-human-neural-tissue-derived-from-induced-27622770","doi":"10.1371/journal.pone.0161969","journal":"PLoS ONE","n_participants":null,"pmid":"27622770","source_url":"https://pubmed.ncbi.nlm.nih.gov/27622770/","study_design":null,"title":"Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer\u2019s Disease Phenotypes","title_match":false,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/sampling-the-conformational-space-of-the-catalytic-subunit-of-human-26623517","doi":"10.7554/elife.11182","journal":"eLife","n_participants":null,"pmid":"26623517","source_url":"https://pubmed.ncbi.nlm.nih.gov/26623517/","study_design":null,"title":"Sampling the conformational space of the catalytic subunit of human \u03b3-secretase","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-cerebellar-phenotypes-7824096","doi":"10.1212/wnl.45.1.1","journal":"Neurology","n_participants":null,"pmid":"7824096","source_url":"https://pubmed.ncbi.nlm.nih.gov/7824096/","study_design":null,"title":"Autosomal dominant cerebellar phenotypes","title_match":true,"year":1995},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/long-term-treatment-with-liraglutide-a-glucagon-like-peptide-1-glp-1-27421117","doi":"10.1371/journal.pone.0158205","journal":"PLoS ONE","n_participants":null,"pmid":"27421117","source_url":"https://pubmed.ncbi.nlm.nih.gov/27421117/","study_design":null,"title":"Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on \u03b2-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer\u2019s Disease","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-caenorhabditis-elegans-impas-gene-imp-2-is-essential-for-15469912","doi":"10.1073/pnas.0406462101","journal":"Proceedings of the National Academy of Sciences","n_participants":null,"pmid":"15469912","source_url":"https://pubmed.ncbi.nlm.nih.gov/15469912/","study_design":null,"title":"The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins","title_match":false,"year":2004},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/risk-factors-in-coronary-heart-disease-14233810","doi":"10.7326/0003-4819-61-5-888","journal":"Annals of Internal Medicine","n_participants":null,"pmid":"14233810","source_url":"https://pubmed.ncbi.nlm.nih.gov/14233810/","study_design":"cross-sectional","title":"Risk Factors in Coronary Heart Disease","title_match":false,"year":1964},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloidosis-a-convoluted-story-11552976","doi":"10.1046/j.1365-2141.2001.02999.x","journal":"British Journal of Haematology","n_participants":60,"pmid":"11552976","source_url":"https://pubmed.ncbi.nlm.nih.gov/11552976/","study_design":null,"title":"Amyloidosis: a convoluted story","title_match":false,"year":2001},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/progressive-posterior-cortical-dysfunction-15477534","doi":"10.1212/01.wnl.0000140290.80962.bf","journal":"Neurology","n_participants":13,"pmid":"15477534","source_url":"https://pubmed.ncbi.nlm.nih.gov/15477534/","study_design":null,"title":"Progressive posterior cortical dysfunction","title_match":false,"year":2004},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/evolutionarily-conserved-susceptibility-of-the-mitochondrial-31697708","doi":"10.1371/journal.pone.0224132","journal":"PLoS ONE","n_participants":null,"pmid":"31697708","source_url":"https://pubmed.ncbi.nlm.nih.gov/31697708/","study_design":null,"title":"Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/follow-up-study-of-risk-factors-in-progressive-supranuclear-palsy-8710069","doi":"10.1212/wnl.47.1.148","journal":"Neurology","n_participants":75,"pmid":"8710069","source_url":"https://pubmed.ncbi.nlm.nih.gov/8710069/","study_design":null,"title":"Follow-up study of risk factors in progressive supranuclear palsy","title_match":false,"year":1996},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/microglial-response-to-amyloid-plaques-in-appsw-transgenic-mice-9422548","doi":null,"journal":"Europe PMC (PubMed Central)","n_participants":null,"pmid":"9422548","source_url":"https://pubmed.ncbi.nlm.nih.gov/9422548/","study_design":null,"title":"Microglial response to amyloid plaques in APPsw transgenic mice","title_match":false,"year":1998},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/stroke-pathophysiology-diagnosis-and-management-563f4c39","doi":"10.7326/0003-4819-108-3-506_3","journal":"Annals of Internal Medicine","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.7326/0003-4819-108-3-506_3","study_design":null,"title":"Stroke: Pathophysiology, Diagnosis, and Management","title_match":false,"year":1988},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/synuclein-shares-physical-and-functional-homology-with-14-3-3-proteins-10407019","doi":"10.1523/jneurosci.19-14-05782.1999","journal":"Journal of Neuroscience","n_participants":null,"pmid":"10407019","source_url":"https://pubmed.ncbi.nlm.nih.gov/10407019/","study_design":null,"title":"\u03b1-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins","title_match":false,"year":1999},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/invited-article-nervous-system-pathology-in-sporadic-parkinson-disease-18474848","doi":"10.1212/01.wnl.0000312279.49272.9f","journal":"Neurology","n_participants":null,"pmid":"18474848","source_url":"https://pubmed.ncbi.nlm.nih.gov/18474848/","study_design":null,"title":"Invited Article: Nervous system pathology in sporadic Parkinson disease","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/lewy-bodies-contain-altered-synuclein-in-brains-of-many-familial-9811326","doi":"10.1016/s0002-9440(10)65722-7","journal":"American Journal Of Pathology","n_participants":65,"pmid":"9811326","source_url":"https://pubmed.ncbi.nlm.nih.gov/9811326/","study_design":null,"title":"Lewy Bodies Contain Altered \u03b1-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes","title_match":true,"year":1998},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/parkinson-s-disease-induced-pluripotent-stem-cells-with-triplication-21863007","doi":"10.1038/ncomms1453","journal":"Nature Communications","n_participants":null,"pmid":"21863007","source_url":"https://pubmed.ncbi.nlm.nih.gov/21863007/","study_design":null,"title":"Parkinson's disease induced pluripotent stem cells with triplication of the \u03b1-synuclein locus","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/scp-apoe-scp-modulated-ainduced-neuroinflammation-in-alzheimer-s-6a932752","doi":"10.1111/jnc.13072","journal":"Journal of Neurochemistry","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1111/jnc.13072","study_design":null,"title":"APOE \u2010modulated A\u03b2\u2010induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neurodegeneration-severity-can-be-predicted-from-early-microglia-6869bfb1","doi":"10.1242/dmm.018788","journal":"Disease Models & Mechanisms","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1242/dmm.018788","study_design":null,"title":"Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/associations-between-brain-inflammatory-profiles-and-human-32076055","doi":"10.1038/s41598-020-59869-5","journal":"Scientific reports","n_participants":154,"pmid":"32076055","source_url":"https://pubmed.ncbi.nlm.nih.gov/32076055/","study_design":null,"title":"Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E \u03b54 genotype","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-ykl-40-and-chitotriosidase-levels-in-32344399","doi":"10.1159/000506282","journal":"Dementia and geriatric cognitive disorders","n_participants":20,"pmid":"32344399","source_url":"https://pubmed.ncbi.nlm.nih.gov/32344399/","study_design":null,"title":"Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/clinical-and-biological-relevance-of-glial-fibrillary-acidic-protein-37924152","doi":"10.1186/s13195-023-01340-4","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"37924152","source_url":"https://pubmed.ncbi.nlm.nih.gov/37924152/","study_design":null,"title":"Clinical and biological relevance of glial fibrillary acidic protein in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/biochemical-neuropathological-and-neuroimaging-characteristics-of-21094210","doi":"10.1016/j.neulet.2010.10.039","journal":"Neuroscience letters","n_participants":null,"pmid":"21094210","source_url":"https://pubmed.ncbi.nlm.nih.gov/21094210/","study_design":null,"title":"Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation","title_match":true,"year":2011},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/sex-differences-in-blood-biomarkers-and-cognitive-performance-in-37279390","doi":"10.1002/alz.13314","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37279390","source_url":"https://pubmed.ncbi.nlm.nih.gov/37279390/","study_design":"cross-sectional","title":"Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau-181-as-a-biomarker-for-amyloid-burden-on-35491781","doi":"10.3233/jad-215639","journal":"Journal of Alzheimer's disease : JAD","n_participants":18,"pmid":"35491781","source_url":"https://pubmed.ncbi.nlm.nih.gov/35491781/","study_design":null,"title":"Blood Phosphorylated Tau 181 as a Biomarker for Amyloid Burden on Brain PET in Cognitively Healthy Adults","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/a-minimally-invasive-dried-blood-spot-biomarker-test-for-the-41491101","doi":"10.1038/s41591-025-04080-0","journal":"Nature medicine","n_participants":337,"pmid":"41491101","source_url":"https://pubmed.ncbi.nlm.nih.gov/41491101/","study_design":null,"title":"A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disease-biomarkers-a-lt-sub-gt-1-40-lt-sub-gt-a-lt-29484263","doi":"10.1002/brb3.903","journal":"Brain and behavior","n_participants":null,"pmid":"29484263","source_url":"https://pubmed.ncbi.nlm.nih.gov/29484263/","study_design":null,"title":"Neurodegenerative disease biomarkers A\u03b21-40, A\u03b21-42, tau, and p-tau181 in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/progressive-myoclonus-epilepsy-in-down-syndrome-patients-with-dementia-24893590","doi":"10.1007/s00415-014-7376-x","journal":"Journal of neurology","n_participants":null,"pmid":"24893590","source_url":"https://pubmed.ncbi.nlm.nih.gov/24893590/","study_design":null,"title":"Progressive myoclonus epilepsy in Down syndrome patients with dementia","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-chain-as-a-surrogate-of-cognitive-decline-34375485","doi":"10.1111/ene.15058","journal":"European journal of neurology","n_participants":null,"pmid":"34375485","source_url":"https://pubmed.ncbi.nlm.nih.gov/34375485/","study_design":null,"title":"Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementia","title_match":true,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/longitudinal-changes-in-the-functional-connectivity-of-individuals-at-38172488","doi":"10.1007/s11357-023-01036-5","journal":"GeroScience","n_participants":null,"pmid":"38172488","source_url":"https://pubmed.ncbi.nlm.nih.gov/38172488/","study_design":"cross-sectional","title":"Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cerebrovascular-pathology-during-the-progression-of-experimental-26774030","doi":"10.1016/j.nbd.2016.01.001","journal":"Neurobiology of disease","n_participants":null,"pmid":"26774030","source_url":"https://pubmed.ncbi.nlm.nih.gov/26774030/","study_design":null,"title":"Cerebrovascular pathology during the progression of experimental Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/reduced-beta-amyloid-production-and-increased-inflammatory-responses-15345711","doi":"10.1074/jbc.m409544200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"15345711","source_url":"https://pubmed.ncbi.nlm.nih.gov/15345711/","study_design":null,"title":"Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice","title_match":true,"year":2004},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-beta-protein-abeta-1-40-protects-neurons-from-damage-induced-14535944","doi":"10.1046/j.1471-4159.2003.02018.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"14535944","source_url":"https://pubmed.ncbi.nlm.nih.gov/14535944/","study_design":null,"title":"Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain","title_match":false,"year":2003},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/regional-distribution-of-synaptic-markers-and-app-correlate-with-24625695","doi":"10.1093/brain/awu046","journal":"Brain : a journal of neurology","n_participants":12,"pmid":"24625695","source_url":"https://pubmed.ncbi.nlm.nih.gov/24625695/","study_design":null,"title":"Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/inhibiting-tlr2-activation-attenuates-amyloid-accumulation-and-glial-27422717","doi":"10.1016/j.bbi.2016.07.143","journal":"Brain, behavior, and immunity","n_participants":null,"pmid":"27422717","source_url":"https://pubmed.ncbi.nlm.nih.gov/27422717/","study_design":null,"title":"Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/forsythoside-b-attenuates-memory-impairment-and-neuroinflammation-via-33059746","doi":"10.1186/s12974-020-01967-2","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"33059746","source_url":"https://pubmed.ncbi.nlm.nih.gov/33059746/","study_design":null,"title":"Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-\u03baB signaling in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/longitudinal-measurement-of-serum-neurofilament-light-in-30786919","doi":"10.1186/s13195-019-0472-5","journal":"Alzheimer's research & therapy","n_participants":61,"pmid":"30786919","source_url":"https://pubmed.ncbi.nlm.nih.gov/30786919/","study_design":"longitudinal study","title":"Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/chronic-neuroinflammation-in-alzheimer-s-disease-new-perspectives-on-25025046","doi":"10.1155/2014/309129","journal":"BioMed research international","n_participants":null,"pmid":"25025046","source_url":"https://pubmed.ncbi.nlm.nih.gov/25025046/","study_design":null,"title":"Chronic neuroinflammation in Alzheimer's disease: new perspectives on animal models and promising candidate drugs","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-new-splice-variant-of-glial-fibrillary-acidic-protein-gfap-epsilon-12058025","doi":"10.1074/jbc.m112121200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"12058025","source_url":"https://pubmed.ncbi.nlm.nih.gov/12058025/","study_design":null,"title":"A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins","title_match":true,"year":2002},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/identification-of-cd40-ligand-in-alzheimer-s-disease-and-in-animal-11755016","doi":"10.1016/s0197-4580(01)00246-9","journal":"Neurobiology of aging","n_participants":null,"pmid":"11755016","source_url":"https://pubmed.ncbi.nlm.nih.gov/11755016/","study_design":null,"title":"Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury","title_match":false,"year":2002},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/csf-t-tau-a42-predicts-white-matter-microstructure-in-healthy-adults-22701578","doi":"10.1371/journal.pone.0037720","journal":"PloS one","n_participants":null,"pmid":"22701578","source_url":"https://pubmed.ncbi.nlm.nih.gov/22701578/","study_design":null,"title":"CSF T-Tau/A\u03b242 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-reduction-with-antisense-oligonucleotides-decreases-33550655","doi":"10.1002/ana.26043","journal":"Annals of neurology","n_participants":null,"pmid":"33550655","source_url":"https://pubmed.ncbi.nlm.nih.gov/33550655/","study_design":null,"title":"Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/aquaporin-expression-in-the-cerebral-cortex-is-increased-at-early-17123487","doi":"10.1016/j.brainres.2006.09.109","journal":"Brain research","n_participants":null,"pmid":"17123487","source_url":"https://pubmed.ncbi.nlm.nih.gov/17123487/","study_design":null,"title":"Aquaporin expression in the cerebral cortex is increased at early stages of Alzheimer disease","title_match":false,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/impaired-cell-proliferation-in-the-subventricular-zone-in-an-19494789","doi":"10.1097/wnr.0b013e32832be77d","journal":"Neuroreport","n_participants":null,"pmid":"19494789","source_url":"https://pubmed.ncbi.nlm.nih.gov/19494789/","study_design":null,"title":"Impaired cell proliferation in the subventricular zone in an Alzheimer's disease model","title_match":false,"year":2009},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/enhanced-neuronal-activity-and-asynchronous-calcium-transients-33347288","doi":"10.1021/acsbiomaterials.0c01583","journal":"ACS biomaterials science & engineering","n_participants":null,"pmid":"33347288","source_url":"https://pubmed.ncbi.nlm.nih.gov/33347288/","study_design":null,"title":"Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-coexistence-of-an-equal-amount-of-alzheimer-s-amyloid-40-and-42-24720730","doi":"10.1111/febs.12813","journal":"The FEBS journal","n_participants":null,"pmid":"24720730","source_url":"https://pubmed.ncbi.nlm.nih.gov/24720730/","study_design":null,"title":"The coexistence of an equal amount of Alzheimer's amyloid-\u03b2 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/identification-of-the-a37-42-peptide-ratio-in-csf-as-an-improved-a-35278341","doi":"10.1002/alz.12646","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35278341","source_url":"https://pubmed.ncbi.nlm.nih.gov/35278341/","study_design":null,"title":"Identification of the A\u03b237/42 peptide ratio in CSF as an improved A\u03b2 biomarker for Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/effects-of-cd2-associated-protein-deficiency-on-amyloid-in-25887956","doi":"10.1186/s13024-015-0006-y","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"25887956","source_url":"https://pubmed.ncbi.nlm.nih.gov/25887956/","study_design":null,"title":"Effects of CD2-associated protein deficiency on amyloid-\u03b2 in neuroblastoma cells and in an APP transgenic mouse model","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/effect-of-presenilin-mutations-on-app-cleavage-insights-into-the-27014058","doi":"10.3389/fnagi.2016.00051","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"27014058","source_url":"https://pubmed.ncbi.nlm.nih.gov/27014058/","study_design":null,"title":"Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD","title_match":true,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-42-40-ratio-and-kalirin-expression-in-alzheimer-disease-with-22429885","doi":"10.1016/j.neurobiolaging.2012.02.015","journal":"Neurobiology of aging","n_participants":null,"pmid":"22429885","source_url":"https://pubmed.ncbi.nlm.nih.gov/22429885/","study_design":null,"title":"\u03b2-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/enhanced-accumulation-of-phosphorylated-alpha-synuclein-and-elevated-18045903","doi":"10.1523/jneurosci.4244-07.2007","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"18045903","source_url":"https://pubmed.ncbi.nlm.nih.gov/18045903/","study_design":null,"title":"Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease","title_match":true,"year":2007},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/candidate-based-screening-via-gene-modulation-in-human-neurons-and-30371777","doi":"10.1093/hmg/ddy376","journal":"Human molecular genetics","n_participants":null,"pmid":"30371777","source_url":"https://pubmed.ncbi.nlm.nih.gov/30371777/","study_design":null,"title":"Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in A\u03b2 and TAU proteostasis","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mutations-in-amyloid-precursor-protein-affect-its-interactions-with-19281847","doi":"10.1016/j.mcn.2009.02.008","journal":"Molecular and cellular neurosciences","n_participants":null,"pmid":"19281847","source_url":"https://pubmed.ncbi.nlm.nih.gov/19281847/","study_design":null,"title":"Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase","title_match":true,"year":2009},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-novel-presenilin-1-mutation-leu85pro-in-early-onset-alzheimer-15534188","doi":"10.1001/archneur.61.11.1773","journal":"Archives of neurology","n_participants":null,"pmid":"15534188","source_url":"https://pubmed.ncbi.nlm.nih.gov/15534188/","study_design":null,"title":"A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis","title_match":true,"year":2004},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genome-editing-applications-of-crispr-cas9-to-promote-in-vitro-29445268","doi":"10.2147/cia.s155145","journal":"Clinical interventions in aging","n_participants":null,"pmid":"29445268","source_url":"https://pubmed.ncbi.nlm.nih.gov/29445268/","study_design":null,"title":"Genome-editing applications of CRISPR-Cas9 to promote in vitro studies of Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-dynamic-mechanism-of-presenilin-1-function-sensitive-gate-26852951","doi":"10.1016/j.nbd.2016.02.008","journal":"Neurobiology of disease","n_participants":null,"pmid":"26852951","source_url":"https://pubmed.ncbi.nlm.nih.gov/26852951/","study_design":null,"title":"The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access","title_match":true,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a42-a40-ratios-of-presenilin-1-mutations-correlate-with-clinical-30412504","doi":"10.3233/jad-180829","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"30412504","source_url":"https://pubmed.ncbi.nlm.nih.gov/30412504/","study_design":null,"title":"A\u03b242/A\u03b240 Ratios of Presenilin 1 Mutations Correlate with Clinical Onset of Alzheimer's Disease","title_match":true,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/identification-of-the-novel-activity-driven-interaction-between-27036734","doi":"10.1186/s12915-016-0248-3","journal":"BMC biology","n_participants":null,"pmid":"27036734","source_url":"https://pubmed.ncbi.nlm.nih.gov/27036734/","study_design":null,"title":"Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta","title_match":true,"year":2016},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/alternative-processing-of-secretase-substrates-in-common-forms-of-21681798","doi":"10.1002/ana.22343","journal":"Annals of neurology","n_participants":158,"pmid":"21681798","source_url":"https://pubmed.ncbi.nlm.nih.gov/21681798/","study_design":null,"title":"Alternative processing of \u03b3-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for \u03b3-secretase dysfunction","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-alzheimer-s-disease-mutations-at-the-same-codon-of-24117942","doi":"10.1111/jnc.12466","journal":"Journal of neurochemistry","n_participants":null,"pmid":"24117942","source_url":"https://pubmed.ncbi.nlm.nih.gov/24117942/","study_design":null,"title":"Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter A\u03b2 production","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-psen1-i143t-mutation-in-a-swedish-family-with-alzheimer-s-disease-20628413","doi":"10.1038/ejhg.2010.107","journal":"European journal of human genetics : EJHG","n_participants":null,"pmid":"20628413","source_url":"https://pubmed.ncbi.nlm.nih.gov/20628413/","study_design":null,"title":"The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of A\u03b2 in different brain regions","title_match":true,"year":2010},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/dynamic-presenilin-1-and-synaptotagmin-1-interaction-modulates-28193235","doi":"10.1186/s13024-017-0159-y","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"28193235","source_url":"https://pubmed.ncbi.nlm.nih.gov/28193235/","study_design":null,"title":"Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid \u03b2 production","title_match":true,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/loss-of-a43-production-caused-by-presenilin-1-mutations-in-the-27100200","doi":"10.1016/j.neuron.2016.03.009","journal":"Neuron","n_participants":null,"pmid":"27100200","source_url":"https://pubmed.ncbi.nlm.nih.gov/27100200/","study_design":null,"title":"Loss of A\u03b243 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain","title_match":true,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuronal-or-glial-expression-of-human-apolipoprotein-e4-affects-16400027","doi":"10.2353/ajpath.2006.050752","journal":"The American journal of pathology","n_participants":null,"pmid":"16400027","source_url":"https://pubmed.ncbi.nlm.nih.gov/16400027/","study_design":null,"title":"Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice","title_match":false,"year":2006},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-like-app-processing-in-wild-type-mice-identifies-26759118","doi":"10.1186/s13024-016-0070-y","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"26759118","source_url":"https://pubmed.ncbi.nlm.nih.gov/26759118/","study_design":null,"title":"Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/association-of-polygenic-risk-score-with-age-at-onset-and-32072450","doi":"10.1007/s12264-020-00469-8","journal":"Neuroscience bulletin","n_participants":null,"pmid":"32072450","source_url":"https://pubmed.ncbi.nlm.nih.gov/32072450/","study_design":null,"title":"Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in a Chinese Cohort","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/dimerization-of-the-transmembrane-domain-of-amyloid-precursor-protein-28790170","doi":"10.1074/jbc.m117.789669","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"28790170","source_url":"https://pubmed.ncbi.nlm.nih.gov/28790170/","study_design":null,"title":"Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the \u03b3-secretase cleavage sites","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/single-molecule-imaging-reveals-a42-a40-ratio-dependent-oligomer-23442968","doi":"10.1016/j.bpj.2012.12.051","journal":"Biophysical journal","n_participants":null,"pmid":"23442968","source_url":"https://pubmed.ncbi.nlm.nih.gov/23442968/","study_design":null,"title":"Single-molecule imaging reveals a\u03b242:a\u03b240 ratio-dependent oligomer growth on neuronal processes","title_match":false,"year":2013},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/novel-presenilin-1-and-2-double-knock-out-cell-line-for-in-vitro-32032730","doi":"10.1016/j.nbd.2020.104785","journal":"Neurobiology of disease","n_participants":null,"pmid":"32032730","source_url":"https://pubmed.ncbi.nlm.nih.gov/32032730/","study_design":null,"title":"Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/highly-pathogenic-alzheimer-s-disease-presenilin-1-p117r-mutation-22810102","doi":"10.3233/jad-2012-121129","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"22810102","source_url":"https://pubmed.ncbi.nlm.nih.gov/22810102/","study_design":null,"title":"Highly pathogenic Alzheimer's disease presenilin 1 P117R mutation causes a specific increase in p53 and p21 protein levels and cell cycle dysregulation in human lymphocytes","title_match":true,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/rna-binding-protein-elavl4-hud-ameliorates-alzheimer-s-disease-35843356","doi":"10.1016/j.pneurobio.2022.102316","journal":"Progress in neurobiology","n_participants":null,"pmid":"35843356","source_url":"https://pubmed.ncbi.nlm.nih.gov/35843356/","study_design":null,"title":"RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/menopausal-hormone-therapy-is-associated-with-worse-levels-of-39783876","doi":"10.1002/alz.14456","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39783876","source_url":"https://pubmed.ncbi.nlm.nih.gov/39783876/","study_design":null,"title":"Menopausal hormone therapy is associated with worse levels of Alzheimer's disease biomarkers in APOE \u03b54-carrying women: An observational study","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/evaluation-of-the-expression-of-amyloid-precursor-protein-and-the-28417423","doi":"10.1007/s12010-017-2468-6","journal":"Applied biochemistry and biotechnology","n_participants":null,"pmid":"28417423","source_url":"https://pubmed.ncbi.nlm.nih.gov/28417423/","study_design":null,"title":"Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/effect-of-glycogen-synthase-kinase-3-mediated-presenilin-1-21238544","doi":"10.1016/j.neuroscience.2010.12.017","journal":"Neuroscience","n_participants":null,"pmid":"21238544","source_url":"https://pubmed.ncbi.nlm.nih.gov/21238544/","study_design":null,"title":"Effect of glycogen synthase kinase 3 \u03b2-mediated presenilin 1 phosphorylation on amyloid \u03b2 production is negatively regulated by insulin receptor cleavage","title_match":true,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-novel-highly-pathogenic-alzheimer-presenilin-1-mutation-in-codon-15004326","doi":"10.3233/jad-2004-6105","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"15004326","source_url":"https://pubmed.ncbi.nlm.nih.gov/15004326/","study_design":null,"title":"A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations","title_match":true,"year":2004},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/levels-of-soluble-interleukin-6-receptor-and-asp358ala-are-associated-36810164","doi":"10.1212/nxi.0000000000200095","journal":"Neurology(R) neuroimmunology & neuroinflammation","n_participants":120,"pmid":"36810164","source_url":"https://pubmed.ncbi.nlm.nih.gov/36810164/","study_design":"cross-sectional","title":"Levels of Soluble Interleukin 6 Receptor and Asp358Ala Are Associated With Cognitive Performance and Alzheimer Disease Biomarkers","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/presenilin-is-essential-for-apoe-secretion-a-novel-role-of-presenilin-34987110","doi":"10.1523/jneurosci.2039-21.2021","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"34987110","source_url":"https://pubmed.ncbi.nlm.nih.gov/34987110/","study_design":null,"title":"Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/3d-bioengineered-neural-tissue-generated-from-patient-derived-ipscs-37365240","doi":"10.1038/s41380-023-02147-3","journal":"Molecular psychiatry","n_participants":null,"pmid":"37365240","source_url":"https://pubmed.ncbi.nlm.nih.gov/37365240/","study_design":null,"title":"3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-processing-and-oxidative-stress-are-altered-34022327","doi":"10.1016/j.mcn.2021.103631","journal":"Molecular and cellular neurosciences","n_participants":null,"pmid":"34022327","source_url":"https://pubmed.ncbi.nlm.nih.gov/34022327/","study_design":null,"title":"Amyloid-\u03b2 precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/reciprocal-relationship-between-app-positioning-relative-to-the-21310068","doi":"10.1186/1750-1326-6-15","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"21310068","source_url":"https://pubmed.ncbi.nlm.nih.gov/21310068/","study_design":null,"title":"Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation","title_match":false,"year":2011},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-s-polygenic-risk-scores-are-associated-with-cognitive-37855447","doi":"10.1002/alz.13506","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37855447","source_url":"https://pubmed.ncbi.nlm.nih.gov/37855447/","study_design":null,"title":"Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-heritability-of-blood-based-biomarkers-related-to-risk-of-37622539","doi":"10.1002/alz.13407","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37622539","source_url":"https://pubmed.ncbi.nlm.nih.gov/37622539/","study_design":null,"title":"The heritability of blood-based biomarkers related to risk of Alzheimer's disease in a population-based sample of early old-age men","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/associations-of-risk-genes-with-onset-age-and-plasma-biomarkers-of-35001095","doi":"10.1038/s41386-021-01258-1","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":3604,"pmid":"35001095","source_url":"https://pubmed.ncbi.nlm.nih.gov/35001095/","study_design":null,"title":"Associations of risk genes with onset age and plasma biomarkers of Alzheimer's disease: a large case-control study in mainland China","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-psen1-l166p-knock-in-mutation-leads-to-amyloid-deposition-in-22459153","doi":"10.1096/fj.12-205542","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"22459153","source_url":"https://pubmed.ncbi.nlm.nih.gov/22459153/","study_design":null,"title":"The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice","title_match":true,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/two-novel-presenilin-1-mutations-i249l-and-p433s-in-early-onset-31235249","doi":"10.1016/j.bbrc.2019.05.185","journal":"Biochemical and biophysical research communications","n_participants":null,"pmid":"31235249","source_url":"https://pubmed.ncbi.nlm.nih.gov/31235249/","study_design":null,"title":"Two novel presenilin-1 mutations (I249L and P433S) in early onset Chinese Alzheimer's pedigrees and their functional characterization","title_match":true,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-novel-psen1-m139l-mutation-found-in-a-chinese-pedigree-with-early-30958370","doi":"10.3233/jad-181291","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"30958370","source_url":"https://pubmed.ncbi.nlm.nih.gov/30958370/","study_design":null,"title":"A Novel PSEN1 M139L Mutation Found in a Chinese Pedigree with Early-Onset Alzheimer's Disease Increases A\u03b242/A\u03b240 ratio","title_match":true,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-cross-sectional-study-on-cerebrospinal-fluid-biomarker-levels-in-23171371","doi":"10.1111/cns.12028","journal":"CNS neuroscience & therapeutics","n_participants":162,"pmid":"23171371","source_url":"https://pubmed.ncbi.nlm.nih.gov/23171371/","study_design":null,"title":"A cross-sectional study on cerebrospinal fluid biomarker levels in cognitively normal elderly subjects with or without a family history of Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-novel-presenilin-2-mutation-v393m-in-early-onset-dementia-with-18727676","doi":"10.1111/j.1468-1331.2008.02256.x","journal":"European journal of neurology","n_participants":null,"pmid":"18727676","source_url":"https://pubmed.ncbi.nlm.nih.gov/18727676/","study_design":null,"title":"A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment","title_match":true,"year":2008},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-combined-effects-of-amyloidosis-and-serotonin-deficiency-by-34924373","doi":"10.3233/jad-210581","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34924373","source_url":"https://pubmed.ncbi.nlm.nih.gov/34924373/","study_design":null,"title":"The Combined Effects of Amyloidosis and Serotonin Deficiency by Tryptophan Hydroxylase-2 Knockout Impacts Viability of the APP/PS1 Mouse Model of Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-novel-psen1-k311r-mutation-discovered-in-chinese-families-with-late-28269784","doi":"10.3233/jad-161188","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28269784","source_url":"https://pubmed.ncbi.nlm.nih.gov/28269784/","study_design":null,"title":"A Novel PSEN1 K311R Mutation Discovered in Chinese Families with Late-Onset Alzheimer's Disease Affects Amyloid-\u03b2 Production and Tau Phosphorylation","title_match":true,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/changed-membrane-integration-and-catalytic-site-conformation-are-two-24918054","doi":"10.1016/j.fob.2014.04.006","journal":"FEBS open bio","n_participants":null,"pmid":"24918054","source_url":"https://pubmed.ncbi.nlm.nih.gov/24918054/","study_design":null,"title":"Changed membrane integration and catalytic site conformation are two mechanisms behind the increased A\u03b242/A\u03b240 ratio by presenilin 1 familial Alzheimer-linked mutations","title_match":true,"year":2014},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-4-gene-dose-effect-on-imaging-and-blood-biomarkers-of-37016464","doi":"10.1186/s13195-023-01209-6","journal":"Alzheimer's research & therapy","n_participants":19,"pmid":"37016464","source_url":"https://pubmed.ncbi.nlm.nih.gov/37016464/","study_design":null,"title":"APOE \u03b54 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/longitudinal-data-in-peripheral-blood-confirm-that-pm20d1-is-a-33298155","doi":"10.1186/s13148-020-00984-5","journal":"Clinical epigenetics","n_participants":649,"pmid":"33298155","source_url":"https://pubmed.ncbi.nlm.nih.gov/33298155/","study_design":"longitudinal study","title":"Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer's disease and implicate its dynamic role in disease progression","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/tdp-43-protein-variants-as-biomarkers-in-amyotrophic-lateral-sclerosis-28122516","doi":"10.1186/s12868-017-0334-7","journal":"BMC neuroscience","n_participants":null,"pmid":"28122516","source_url":"https://pubmed.ncbi.nlm.nih.gov/28122516/","study_design":null,"title":"TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis","title_match":false,"year":2017},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/asian-cohort-for-alzheimer-s-disease-acad-pilot-study-on-genetic-and-38215053","doi":"10.1002/alz.13611","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":606,"pmid":"38215053","source_url":"https://pubmed.ncbi.nlm.nih.gov/38215053/","study_design":null,"title":"Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians","title_match":true,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/frontal-variant-of-alzheimer-s-disease-with-asymmetric-presentation-31989779","doi":"10.1002/brb3.1548","journal":"Brain and behavior","n_participants":null,"pmid":"31989779","source_url":"https://pubmed.ncbi.nlm.nih.gov/31989779/","study_design":null,"title":"Frontal variant of Alzheimer's disease with asymmetric presentation mimicking frontotemporal dementia: Case report and literature review","title_match":false,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/classification-and-deep-learning-based-prediction-of-alzheimer-37386009","doi":"10.1038/s41398-023-02531-1","journal":"Translational psychiatry","n_participants":1947,"pmid":"37386009","source_url":"https://pubmed.ncbi.nlm.nih.gov/37386009/","study_design":null,"title":"Classification and deep-learning-based prediction of Alzheimer disease subtypes by using genomic data","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cell-free-dna-as-peripheral-biomarker-of-alzheimer-s-disease-38607732","doi":"10.14336/ad.2024.0329","journal":"Aging and disease","n_participants":null,"pmid":"38607732","source_url":"https://pubmed.ncbi.nlm.nih.gov/38607732/","study_design":null,"title":"Cell-Free DNA As Peripheral Biomarker of Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/risk-factors-of-behavioral-and-psychological-symptoms-in-patients-30369216","doi":"10.4082/kjfm.17.0061","journal":"Korean journal of family medicine","n_participants":1128,"pmid":"30369216","source_url":"https://pubmed.ncbi.nlm.nih.gov/30369216/","study_design":"cross-sectional","title":"Risk Factors of Behavioral and Psychological Symptoms in Patients with Alzheimer Disease: The Clinical Research of Dementia of South Korea Study","title_match":false,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/asic-e4-interplay-of-beta-amyloid-synaptic-density-and-35222254","doi":"10.3389/fneur.2022.826423","journal":"Frontiers in neurology","n_participants":19,"pmid":"35222254","source_url":"https://pubmed.ncbi.nlm.nih.gov/35222254/","study_design":null,"title":"ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease - Study Protocol and Baseline Characteristics","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/older-us-adults-experiences-with-and-views-about-cognitive-screening-39822297","doi":"10.1002/dad2.70067","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1298,"pmid":"39822297","source_url":"https://pubmed.ncbi.nlm.nih.gov/39822297/","study_design":null,"title":"Older US adults' experiences with and views about cognitive screening and blood biomarker testing for Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-public-resource-of-baseline-data-from-the-alzheimer-s-prevention-36373344","doi":"10.1002/alz.12843","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36373344","source_url":"https://pubmed.ncbi.nlm.nih.gov/36373344/","study_design":null,"title":"A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-in-patients-with-frontotemporal-dementia-33626531","doi":"10.1159/000513877","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"33626531","source_url":"https://pubmed.ncbi.nlm.nih.gov/33626531/","study_design":"cross-sectional","title":"Serum Neurofilament Light in Patients with Frontotemporal Dementia Caused by CHMP2B Mutation","title_match":false,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/blood-biomarker-profiles-in-young-onset-neurocognitive-disorders-a-39825484","doi":"10.1177/00048674241312805","journal":"The Australian and New Zealand journal of psychiatry","n_participants":18,"pmid":"39825484","source_url":"https://pubmed.ncbi.nlm.nih.gov/39825484/","study_design":null,"title":"Blood biomarker profiles in young-onset neurocognitive disorders: A cohort study","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/sex-differences-in-cognitive-abilities-among-children-with-the-34463747","doi":"10.1001/jamanetworkopen.2021.21697","journal":"JAMA network open","n_participants":null,"pmid":"34463747","source_url":"https://pubmed.ncbi.nlm.nih.gov/34463747/","study_design":"cohort study","title":"Sex Differences in Cognitive Abilities Among Children With the Autosomal Dominant Alzheimer Disease Presenilin 1 E280A Variant From a Colombian Cohort","title_match":true,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-27188934","doi":"10.1038/nrdp.2015.56","journal":"Nature reviews. Disease primers","n_participants":null,"pmid":"27188934","source_url":"https://pubmed.ncbi.nlm.nih.gov/27188934/","study_design":null,"title":"Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/ammonia-key-factor-in-the-pathogenesis-of-hepatic-encephalopathy-3306479","doi":"10.1007/bf02833598","journal":"Neurochemical pathology","n_participants":null,"pmid":"3306479","source_url":"https://pubmed.ncbi.nlm.nih.gov/3306479/","study_design":null,"title":"Ammonia: key factor in the pathogenesis of hepatic encephalopathy","title_match":false,"year":1987},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-prevention-initiative-a-plan-to-accelerate-the-evaluation-21971471","doi":"10.3233/jad-2011-0059","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21971471","source_url":"https://pubmed.ncbi.nlm.nih.gov/21971471/","study_design":null,"title":"Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/consensus-report-of-the-working-group-on-molecular-and-biochemical-9558143","doi":null,"journal":"Neurobiology of aging","n_participants":null,"pmid":"9558143","source_url":"https://pubmed.ncbi.nlm.nih.gov/9558143/","study_design":null,"title":"Consensus report of the Working Group on: \"Molecular and Biochemical Markers of Alzheimer's Disease\". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group","title_match":false,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/stable-expression-and-secretion-of-apolipoproteins-e3-and-e4-in-mouse-7592957","doi":"10.1074/jbc.270.45.27063","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"7592957","source_url":"https://pubmed.ncbi.nlm.nih.gov/7592957/","study_design":null,"title":"Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth","title_match":false,"year":1995},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/blood-neuro-exosomal-synaptic-proteins-predict-alzheimer-s-disease-at-32776690","doi":"10.1002/alz.12166","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"32776690","source_url":"https://pubmed.ncbi.nlm.nih.gov/32776690/","study_design":null,"title":"Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-proteomics-define-the-natural-history-of-37550416","doi":"10.1038/s41591-023-02476-4","journal":"Nature medicine","n_participants":null,"pmid":"37550416","source_url":"https://pubmed.ncbi.nlm.nih.gov/37550416/","study_design":null,"title":"Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/increased-in-vivo-amyloid-42-production-exchange-and-loss-in-23761040","doi":"10.1126/scitranslmed.3005615","journal":"Science translational medicine","n_participants":null,"pmid":"23761040","source_url":"https://pubmed.ncbi.nlm.nih.gov/23761040/","study_design":null,"title":"Increased in vivo amyloid-\u03b242 production, exchange, and loss in presenilin mutation carriers","title_match":true,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/role-of-the-beta-amyloid-protein-in-alzheimer-s-disease-7896005","doi":"10.1096/fasebj.9.5.7896005","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"7896005","source_url":"https://pubmed.ncbi.nlm.nih.gov/7896005/","study_design":null,"title":"Role of the beta-amyloid protein in Alzheimer's disease","title_match":false,"year":1995},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/screening-over-speech-in-unselected-populations-for-clinical-trials-36946458","doi":"10.14283/jpad.2023.11","journal":"The journal of prevention of Alzheimer's disease","n_participants":1000,"pmid":"36946458","source_url":"https://pubmed.ncbi.nlm.nih.gov/36946458/","study_design":"longitudinal study","title":"Screening over Speech in Unselected Populations for Clinical Trials in AD (PROSPECT-AD): Study Design and Protocol","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/family-history-of-alzheimer-s-disease-limits-improvement-in-cognitive-26770731","doi":"10.1177/2050312114539477","journal":"SAGE open medicine","n_participants":null,"pmid":"26770731","source_url":"https://pubmed.ncbi.nlm.nih.gov/26770731/","study_design":null,"title":"Family history of Alzheimer's disease limits improvement in cognitive function after bariatric surgery","title_match":true,"year":2014},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/impact-of-short-term-computerized-cognitive-training-on-cognition-in-38642588","doi":"10.1016/j.jamda.2024.03.008","journal":"Journal of the American Medical Directors Association","n_participants":6544,"pmid":"38642588","source_url":"https://pubmed.ncbi.nlm.nih.gov/38642588/","study_design":"randomized controlled trial","title":"Impact of Short-Term Computerized Cognitive Training on Cognition in Older Adults With and Without Genetic Risk of Alzheimer's Disease: Outcomes From the START Randomized Controlled Trial","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/primary-health-care-providers-knowledge-of-dementia-and-cognitive-37846370","doi":"10.1177/20503121231204224","journal":"SAGE open medicine","n_participants":null,"pmid":"37846370","source_url":"https://pubmed.ncbi.nlm.nih.gov/37846370/","study_design":"cross-sectional","title":"Primary health care providers knowledge of dementia and cognitive assessment tools for elderly populations in Southeast Nigeria: A pilot survey","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-mapp-room-memory-test-examining-contextual-memory-using-a-novel-38374753","doi":"10.14283/jpad.2024.7","journal":"The journal of prevention of Alzheimer's disease","n_participants":15,"pmid":"38374753","source_url":"https://pubmed.ncbi.nlm.nih.gov/38374753/","study_design":null,"title":"The MAPP Room Memory Test: Examining Contextual Memory Using a Novel Computerized Test in Cognitively-Unimpaired Individuals with Autosomal Dominant Alzheimer's Disease","title_match":true,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/answer-als-a-large-scale-resource-for-sporadic-and-familial-als-6e340a67","doi":"10.21203/rs.3.rs-96858/v1","journal":"Nature neuroscience","n_participants":1046,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-96858/v1","study_design":null,"title":"Answer ALS: A Large-Scale Resource for Sporadic and Familial ALS Combining Clinical Data with Multi-Omics Data from Induced Pluripotent Cell Lines","title_match":true,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/remote-digital-cognitive-assessment-in-a-trial-ready-alzheimer-s-42719037","doi":"10.1002/trc2.70311","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"42719037","source_url":"https://pubmed.ncbi.nlm.nih.gov/42719037/","study_design":null,"title":"Remote digital cognitive assessment in a trial-ready Alzheimer's disease cohort: A scalable approach for early intervention studies","title_match":false,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/risk-factors-for-alzheimer-s-disease-31556570","doi":"10.5114/fn.2019.85929","journal":"Folia neuropathologica","n_participants":null,"pmid":"31556570","source_url":"https://pubmed.ncbi.nlm.nih.gov/31556570/","study_design":null,"title":"Risk factors for Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/aluminium-as-a-risk-factor-in-alzheimer-s-disease-with-emphasis-on-11470314","doi":"10.1016/s0361-9230(01)00459-2","journal":"Brain research bulletin","n_participants":null,"pmid":"11470314","source_url":"https://pubmed.ncbi.nlm.nih.gov/11470314/","study_design":null,"title":"Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water","title_match":false,"year":2001},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neuronal-hyperexcitability-in-alzheimer-s-disease-what-are-the-35732622","doi":"10.1038/s41398-022-02024-7","journal":"Translational psychiatry","n_participants":null,"pmid":"35732622","source_url":"https://pubmed.ncbi.nlm.nih.gov/35732622/","study_design":null,"title":"Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/ldl-receptor-related-protein-a-multifunctional-apoe-receptor-binds-7543026","doi":"10.1016/0092-8674(95)90320-8","journal":"Cell","n_participants":null,"pmid":"7543026","source_url":"https://pubmed.ncbi.nlm.nih.gov/7543026/","study_design":null,"title":"LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation","title_match":false,"year":1995},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon-4-allele-distributions-in-late-onset-8103823","doi":"10.1016/0140-6736(93)91709-u","journal":"Lancet (London, England)","n_participants":null,"pmid":"8103823","source_url":"https://pubmed.ncbi.nlm.nih.gov/8103823/","study_design":null,"title":"Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases","title_match":false,"year":1993},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/gain-of-toxic-apolipoprotein-e4-effects-in-human-ipsc-derived-neurons-29632371","doi":"10.1038/s41591-018-0004-z","journal":"Nature medicine","n_participants":null,"pmid":"29632371","source_url":"https://pubmed.ncbi.nlm.nih.gov/29632371/","study_design":null,"title":"Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-an-emerging-therapeutic-target-for-alzheimer-s-disease-30890171","doi":"10.1186/s12916-019-1299-4","journal":"BMC medicine","n_participants":null,"pmid":"30890171","source_url":"https://pubmed.ncbi.nlm.nih.gov/30890171/","study_design":null,"title":"ApoE4: an emerging therapeutic target for Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-and-endosomal-lysosomal-dysfunction-in-28663518","doi":"10.1096/fj.201700359","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"28663518","source_url":"https://pubmed.ncbi.nlm.nih.gov/28663518/","study_design":null,"title":"Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon-4-allele-is-associated-with-deposition-of-7585009","doi":"10.1038/nm0295-135","journal":"Nature medicine","n_participants":null,"pmid":"7585009","source_url":"https://pubmed.ncbi.nlm.nih.gov/7585009/","study_design":null,"title":"Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury","title_match":false,"year":1995},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/gab2-alleles-modify-alzheimer-s-risk-in-apoe-epsilon4-carriers-17553421","doi":"10.1016/j.neuron.2007.05.022","journal":"Neuron","n_participants":null,"pmid":"17553421","source_url":"https://pubmed.ncbi.nlm.nih.gov/17553421/","study_design":null,"title":"GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers","title_match":false,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-in-alzheimer-s-disease-an-update-24821312","doi":"10.1146/annurev-neuro-071013-014300","journal":"Annual review of neuroscience","n_participants":null,"pmid":"24821312","source_url":"https://pubmed.ncbi.nlm.nih.gov/24821312/","study_design":null,"title":"Apolipoprotein E in Alzheimer's disease: an update","title_match":false,"year":2014},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-receptors-and-modulation-of-alzheimer-s-disease-28434655","doi":"10.1016/j.biopsych.2017.03.003","journal":"Biological psychiatry","n_participants":null,"pmid":"28434655","source_url":"https://pubmed.ncbi.nlm.nih.gov/28434655/","study_design":null,"title":"Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/lt-i-gt-apoe4-lt-i-gt-disrupts-intracellular-lipid-homeostasis-in-33658354","doi":"10.1126/scitranslmed.aaz4564","journal":"Science translational medicine","n_participants":null,"pmid":"33658354","source_url":"https://pubmed.ncbi.nlm.nih.gov/33658354/","study_design":null,"title":"APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/lipid-accumulation-induced-by-apoe4-impairs-microglial-surveillance-35931030","doi":"10.1016/j.stem.2022.07.005","journal":"Cell stem cell","n_participants":null,"pmid":"35931030","source_url":"https://pubmed.ncbi.nlm.nih.gov/35931030/","study_design":null,"title":"Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/isoform-specific-effects-of-human-apolipoprotein-e-on-brain-function-9724804","doi":"10.1073/pnas.95.18.10914","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9724804","source_url":"https://pubmed.ncbi.nlm.nih.gov/9724804/","study_design":null,"title":"Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females","title_match":false,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/modification-of-brain-aging-and-neurodegenerative-disorders-by-genes-12087131","doi":"10.1152/physrev.00004.2002","journal":"Physiological reviews","n_participants":null,"pmid":"12087131","source_url":"https://pubmed.ncbi.nlm.nih.gov/12087131/","study_design":null,"title":"Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior","title_match":false,"year":2002},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/reduced-grid-cell-like-representations-in-adults-at-genetic-risk-for-26494756","doi":"10.1126/science.aac8128","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"26494756","source_url":"https://pubmed.ncbi.nlm.nih.gov/26494756/","study_design":null,"title":"Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease","title_match":true,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-causes-age-and-tau-dependent-impairment-of-20943911","doi":"10.1523/jneurosci.4040-10.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"20943911","source_url":"https://pubmed.ncbi.nlm.nih.gov/20943911/","study_design":null,"title":"Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-effects-in-alzheimer-s-disease-are-mediated-by-22637583","doi":"10.1093/brain/aws127","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"22637583","source_url":"https://pubmed.ncbi.nlm.nih.gov/22637583/","study_design":null,"title":"Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-\u03b2","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genetic-studies-and-transgenic-models-9928488","doi":"10.1146/annurev.genet.32.1.461","journal":"Annual review of genetics","n_participants":null,"pmid":"9928488","source_url":"https://pubmed.ncbi.nlm.nih.gov/9928488/","study_design":null,"title":"Alzheimer's disease: genetic studies and transgenic models","title_match":false,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/impact-of-apolipoprotein-e-apoe-polymorphism-on-brain-apoe-levels-18987181","doi":"10.1523/jneurosci.1972-08.2008","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"18987181","source_url":"https://pubmed.ncbi.nlm.nih.gov/18987181/","study_design":null,"title":"Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-regulates-brain-apolipoprotein-e-and-17920016","doi":"10.1016/j.neuron.2007.08.008","journal":"Neuron","n_participants":null,"pmid":"17920016","source_url":"https://pubmed.ncbi.nlm.nih.gov/17920016/","study_design":null,"title":"Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1","title_match":false,"year":2007},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/involvement-of-lipids-in-alzheimer-s-disease-pathology-and-potential-32581851","doi":"10.3389/fphys.2020.00598","journal":"Frontiers in physiology","n_participants":null,"pmid":"32581851","source_url":"https://pubmed.ncbi.nlm.nih.gov/32581851/","study_design":null,"title":"Involvement of Lipids in Alzheimer's Disease Pathology and Potential Therapies","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/role-of-lrp1-in-the-pathogenesis-of-alzheimer-s-disease-evidence-from-28381441","doi":"10.1194/jlr.r075796","journal":"Journal of lipid research","n_participants":null,"pmid":"28381441","source_url":"https://pubmed.ncbi.nlm.nih.gov/28381441/","study_design":null,"title":"Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/posterior-cortical-atrophy-clinical-characteristics-and-differences-12053130","doi":"10.1159/000058331","journal":"Dementia and geriatric cognitive disorders","n_participants":15,"pmid":"12053130","source_url":"https://pubmed.ncbi.nlm.nih.gov/12053130/","study_design":null,"title":"Posterior cortical atrophy: clinical characteristics and differences compared to Alzheimer's disease","title_match":false,"year":2002},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/expression-of-human-apolipoprotein-e3-or-e4-in-the-brains-of-apoe-10366621","doi":"10.1523/jneurosci.19-12-04867.1999","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"10366621","source_url":"https://pubmed.ncbi.nlm.nih.gov/10366621/","study_design":null,"title":"Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration","title_match":false,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/results-of-a-high-resolution-genome-screen-of-437-alzheimer-s-disease-12490529","doi":"10.1093/hmg/ddg007","journal":"Human molecular genetics","n_participants":null,"pmid":"12490529","source_url":"https://pubmed.ncbi.nlm.nih.gov/12490529/","study_design":null,"title":"Results of a high-resolution genome screen of 437 Alzheimer's disease families","title_match":false,"year":2003},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-facilitates-neuritic-and-cerebrovascular-plaque-10852539","doi":"10.1002/1531-8249(200006)47:6<739::aid-ana6>3.0.co;2-8","journal":"Annals of neurology","n_participants":null,"pmid":"10852539","source_url":"https://pubmed.ncbi.nlm.nih.gov/10852539/","study_design":null,"title":"Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model","title_match":false,"year":2000},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-and-pathological-correlates-of-apolipoprotein-e-epsilon-4-in-8572669","doi":"10.1002/ana.410390110","journal":"Annals of neurology","n_participants":null,"pmid":"8572669","source_url":"https://pubmed.ncbi.nlm.nih.gov/8572669/","study_design":"longitudinal study","title":"Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease","title_match":false,"year":1996},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-impairs-neuronal-insulin-signaling-by-trapping-28957663","doi":"10.1016/j.neuron.2017.09.003","journal":"Neuron","n_participants":null,"pmid":"28957663","source_url":"https://pubmed.ncbi.nlm.nih.gov/28957663/","study_design":null,"title":"Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-pathogenesis-and-therapeutic-interventions-15177383","doi":"10.1016/j.jocn.2003.12.007","journal":"Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia","n_participants":null,"pmid":"15177383","source_url":"https://pubmed.ncbi.nlm.nih.gov/15177383/","study_design":null,"title":"Alzheimer's disease pathogenesis and therapeutic interventions","title_match":false,"year":2004},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/menopause-impacts-human-brain-structure-connectivity-energy-34108509","doi":"10.1038/s41598-021-90084-y","journal":"Scientific reports","n_participants":null,"pmid":"34108509","source_url":"https://pubmed.ncbi.nlm.nih.gov/34108509/","study_design":null,"title":"Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-associated-pericytes-internalize-and-clear-30340601","doi":"10.1186/s13024-018-0286-0","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"30340601","source_url":"https://pubmed.ncbi.nlm.nih.gov/30340601/","study_design":"post-hoc analysis","title":"Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-\u03b242 by LRP1-dependent apolipoprotein E isoform-specific mechanism","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/susceptibility-locus-for-alzheimer-s-disease-on-chromosome-10-11125144","doi":"10.1126/science.290.5500.2304","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"11125144","source_url":"https://pubmed.ncbi.nlm.nih.gov/11125144/","study_design":null,"title":"Susceptibility locus for Alzheimer's disease on chromosome 10","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-beta-protein-clearance-and-degradation-abcd-pathways-and-25523424","doi":"10.2174/1567205012666141218140953","journal":"Current Alzheimer research","n_participants":null,"pmid":"25523424","source_url":"https://pubmed.ncbi.nlm.nih.gov/25523424/","study_design":null,"title":"Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mouse-models-of-alzheimer-s-disease-22142973","doi":"10.1016/j.brainresbull.2011.11.017","journal":"Brain research bulletin","n_participants":null,"pmid":"22142973","source_url":"https://pubmed.ncbi.nlm.nih.gov/22142973/","study_design":null,"title":"Mouse models of Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/regulation-of-beta-amyloid-production-in-neurons-by-astrocyte-derived-34385305","doi":"10.1073/pnas.2102191118","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"34385305","source_url":"https://pubmed.ncbi.nlm.nih.gov/34385305/","study_design":null,"title":"Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/monoaminergic-neuropathology-in-alzheimer-s-disease-27084356","doi":"10.1016/j.pneurobio.2016.04.001","journal":"Progress in neurobiology","n_participants":null,"pmid":"27084356","source_url":"https://pubmed.ncbi.nlm.nih.gov/27084356/","study_design":null,"title":"Monoaminergic neuropathology in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-genome-wide-association-study-for-late-onset-alzheimer-s-disease-18823527","doi":"10.1186/1755-8794-1-44","journal":"BMC medical genomics","n_participants":1082,"pmid":"18823527","source_url":"https://pubmed.ncbi.nlm.nih.gov/18823527/","study_design":null,"title":"A genome-wide association study for late-onset Alzheimer's disease using DNA pooling","title_match":false,"year":2008},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/pathway-specific-polygenic-risk-scores-as-predictors-of-amyloid-27662287","doi":"10.3233/jad-160195","journal":"Journal of Alzheimer's disease : JAD","n_participants":1200,"pmid":"27662287","source_url":"https://pubmed.ncbi.nlm.nih.gov/27662287/","study_design":"meta-analysis","title":"Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-\u03b2 Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease","title_match":true,"year":2017},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/genome-wide-survival-study-identifies-a-novel-synaptic-locus-and-33958783","doi":"10.1038/s41588-021-00847-6","journal":"Nature genetics","n_participants":3821,"pmid":"33958783","source_url":"https://pubmed.ncbi.nlm.nih.gov/33958783/","study_design":"longitudinal study","title":"Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/functional-regulatory-variants-implicate-distinct-transcriptional-35981026","doi":"10.1126/science.abi8654","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"35981026","source_url":"https://pubmed.ncbi.nlm.nih.gov/35981026/","study_design":null,"title":"Functional regulatory variants implicate distinct transcriptional networks in dementia","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-lipidome-is-dysregulated-in-alzheimer-s-disease-and-is-34092785","doi":"10.1038/s41398-021-01362-2","journal":"Translational psychiatry","n_participants":null,"pmid":"34092785","source_url":"https://pubmed.ncbi.nlm.nih.gov/34092785/","study_design":null,"title":"Plasma lipidome is dysregulated in Alzheimer's disease and is associated with disease risk genes","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-new-genetic-landscape-of-alzheimer-s-disease-from-amyloid-cascade-30982098","doi":"10.1007/s00401-019-02004-0","journal":"Acta neuropathologica","n_participants":null,"pmid":"30982098","source_url":"https://pubmed.ncbi.nlm.nih.gov/30982098/","study_design":null,"title":"The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?","title_match":false,"year":2019},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/whole-exome-sequencing-in-20-197-persons-for-rare-variants-in-30009200","doi":"10.1002/acn3.582","journal":"Annals of clinical and translational neurology","n_participants":20197,"pmid":"30009200","source_url":"https://pubmed.ncbi.nlm.nih.gov/30009200/","study_design":"case-control study","title":"Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-of-sporadic-late-onset-alzheimer-s-disease-28943286","doi":"10.1016/j.jalz.2017.08.013","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"28943286","source_url":"https://pubmed.ncbi.nlm.nih.gov/28943286/","study_design":null,"title":"Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms","title_match":true,"year":2018},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/dissecting-the-genetic-relationship-between-cardiovascular-risk-30413934","doi":"10.1007/s00401-018-1928-6","journal":"Acta neuropathologica","n_participants":null,"pmid":"30413934","source_url":"https://pubmed.ncbi.nlm.nih.gov/30413934/","study_design":"meta-analysis","title":"Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genome-wide-scan-of-healthy-human-connectome-discovers-spon1-gene-23471985","doi":"10.1073/pnas.1216206110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"23471985","source_url":"https://pubmed.ncbi.nlm.nih.gov/23471985/","study_design":"post-hoc analysis","title":"Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity","title_match":false,"year":2013},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/tmem106b-p-t185s-regulates-tmem106b-protein-levels-implications-for-23742080","doi":"10.1111/jnc.12329","journal":"Journal of neurochemistry","n_participants":null,"pmid":"23742080","source_url":"https://pubmed.ncbi.nlm.nih.gov/23742080/","study_design":null,"title":"TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia","title_match":false,"year":2013},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/a-genome-wide-association-study-of-aging-21782286","doi":"10.1016/j.neurobiolaging.2011.05.026","journal":"Neurobiology of aging","n_participants":null,"pmid":"21782286","source_url":"https://pubmed.ncbi.nlm.nih.gov/21782286/","study_design":"meta-analysis","title":"A genome-wide association study of aging","title_match":false,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/protective-genes-and-pathways-in-alzheimer-s-disease-moving-towards-33926499","doi":"10.1186/s13024-021-00452-5","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"33926499","source_url":"https://pubmed.ncbi.nlm.nih.gov/33926499/","study_design":null,"title":"Protective genes and pathways in Alzheimer's disease: moving towards precision interventions","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/snps-associated-with-cerebrospinal-fluid-phospho-tau-levels-influence-20862329","doi":"10.1371/journal.pgen.1001101","journal":"PLoS genetics","n_participants":null,"pmid":"20862329","source_url":"https://pubmed.ncbi.nlm.nih.gov/20862329/","study_design":"case-control study","title":"SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/polygenic-score-prediction-captures-nearly-all-common-genetic-risk-27595457","doi":"10.1016/j.neurobiolaging.2016.07.018","journal":"Neurobiology of aging","n_participants":null,"pmid":"27595457","source_url":"https://pubmed.ncbi.nlm.nih.gov/27595457/","study_design":null,"title":"Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease","title_match":true,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-selection-landscape-and-genetic-legacy-of-ancient-eurasians-38200293","doi":"10.1038/s41586-023-06705-1","journal":"Nature","n_participants":null,"pmid":"38200293","source_url":"https://pubmed.ncbi.nlm.nih.gov/38200293/","study_design":null,"title":"The selection landscape and genetic legacy of ancient Eurasians","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genetic-risk-for-alzheimer-s-disease-is-concentrated-in-specific-29482603","doi":"10.1186/s13073-018-0523-8","journal":"Genome medicine","n_participants":null,"pmid":"29482603","source_url":"https://pubmed.ncbi.nlm.nih.gov/29482603/","study_design":null,"title":"Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks","title_match":true,"year":2018},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/mitochondrial-dna-point-mutations-and-relative-copy-number-in-1363-28153046","doi":"10.1186/s40478-016-0404-6","journal":"Acta neuropathologica communications","n_participants":1363,"pmid":"28153046","source_url":"https://pubmed.ncbi.nlm.nih.gov/28153046/","study_design":null,"title":"Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/what-we-know-about-tmem106b-in-neurodegeneration-27543298","doi":"10.1007/s00401-016-1610-9","journal":"Acta neuropathologica","n_participants":50000,"pmid":"27543298","source_url":"https://pubmed.ncbi.nlm.nih.gov/27543298/","study_design":null,"title":"What we know about TMEM106B in neurodegeneration","title_match":false,"year":2016},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/brain-scans-from-21-297-individuals-reveal-the-genetic-architecture-30279459","doi":"10.1038/s41380-018-0262-7","journal":"Molecular psychiatry","n_participants":21297,"pmid":"30279459","source_url":"https://pubmed.ncbi.nlm.nih.gov/30279459/","study_design":null,"title":"Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/25-hydroxycholesterol-amplifies-microglial-il-1-production-in-an-apoe-32552741","doi":"10.1186/s12974-020-01869-3","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"32552741","source_url":"https://pubmed.ncbi.nlm.nih.gov/32552741/","study_design":null,"title":"25-Hydroxycholesterol amplifies microglial IL-1\u03b2 production in an apoE isoform-dependent manner","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-role-of-picalm-in-alzheimer-s-disease-25186232","doi":"10.1007/s12035-014-8878-3","journal":"Molecular neurobiology","n_participants":null,"pmid":"25186232","source_url":"https://pubmed.ncbi.nlm.nih.gov/25186232/","study_design":null,"title":"The Role of PICALM in Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/gene-wide-analysis-detects-two-new-susceptibility-genes-for-alzheimer-24922517","doi":"10.1371/journal.pone.0094661","journal":"PloS one","n_participants":null,"pmid":"24922517","source_url":"https://pubmed.ncbi.nlm.nih.gov/24922517/","study_design":null,"title":"Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/family-based-association-analyses-of-imputed-genotypes-reveal-genome-26830138","doi":"10.1038/mp.2015.218","journal":"Molecular psychiatry","n_participants":3500,"pmid":"26830138","source_url":"https://pubmed.ncbi.nlm.nih.gov/26830138/","study_design":"meta-analysis","title":"Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3","title_match":false,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/late-onset-spinal-motor-neuronopathy-is-caused-by-mutation-in-chchd10-25428574","doi":"10.1002/ana.24319","journal":"Annals of neurology","n_participants":55,"pmid":"25428574","source_url":"https://pubmed.ncbi.nlm.nih.gov/25428574/","study_design":null,"title":"Late onset spinal motor neuronopathy is caused by mutation in CHCHD10","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-s-disease-recent-advances-19341505","doi":"10.1186/gm34","journal":"Genome medicine","n_participants":null,"pmid":"19341505","source_url":"https://pubmed.ncbi.nlm.nih.gov/19341505/","study_design":null,"title":"Genetics of Alzheimer's disease: recent advances","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/complement-receptor-1-cr1-and-alzheimer-s-disease-21840620","doi":"10.1016/j.imbio.2011.07.017","journal":"Immunobiology","n_participants":null,"pmid":"21840620","source_url":"https://pubmed.ncbi.nlm.nih.gov/21840620/","study_design":null,"title":"Complement receptor 1 (CR1) and Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/polygenic-regression-uncovers-trait-relevant-cellular-contexts-37719150","doi":"10.1016/j.xgen.2023.100383","journal":"Cell genomics","n_participants":null,"pmid":"37719150","source_url":"https://pubmed.ncbi.nlm.nih.gov/37719150/","study_design":null,"title":"Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data","title_match":true,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/synuclein-bac-transgenic-mice-exhibit-rbd-like-behaviour-and-hyposmia-31816026","doi":"10.1093/brain/awz380","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"31816026","source_url":"https://pubmed.ncbi.nlm.nih.gov/31816026/","study_design":null,"title":"\u03b1-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetic-markers-for-diagnosis-and-pathogenesis-of-alzheimer-s-disease-24838203","doi":"10.1016/j.gene.2014.05.031","journal":"Gene","n_participants":null,"pmid":"24838203","source_url":"https://pubmed.ncbi.nlm.nih.gov/24838203/","study_design":null,"title":"Genetic markers for diagnosis and pathogenesis of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/systematic-tissue-specific-functional-annotation-of-the-human-genome-28742084","doi":"10.1371/journal.pgen.1006933","journal":"PLoS genetics","n_participants":null,"pmid":"28742084","source_url":"https://pubmed.ncbi.nlm.nih.gov/28742084/","study_design":null,"title":"Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/quantitative-interaction-proteomics-of-neurodegenerative-disease-25959826","doi":"10.1016/j.celrep.2015.04.030","journal":"Cell reports","n_participants":null,"pmid":"25959826","source_url":"https://pubmed.ncbi.nlm.nih.gov/25959826/","study_design":null,"title":"Quantitative interaction proteomics of neurodegenerative disease proteins","title_match":false,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/evaluation-of-cd33-as-a-genetic-risk-factor-for-alzheimer-s-disease-30949760","doi":"10.1007/s00401-019-02000-4","journal":"Acta neuropathologica","n_participants":null,"pmid":"30949760","source_url":"https://pubmed.ncbi.nlm.nih.gov/30949760/","study_design":null,"title":"Evaluation of CD33 as a genetic risk factor for Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/systemic-inflammation-as-a-predictor-of-brain-aging-contributions-of-29357308","doi":"10.1016/j.neuroimage.2017.12.027","journal":"NeuroImage","n_participants":226,"pmid":"29357308","source_url":"https://pubmed.ncbi.nlm.nih.gov/29357308/","study_design":"longitudinal study","title":"Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk","title_match":true,"year":2018},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/genetics-of-migraine-insights-into-the-molecular-basis-of-migraine-28271496","doi":"10.1111/head.13053","journal":"Headache","n_participants":null,"pmid":"28271496","source_url":"https://pubmed.ncbi.nlm.nih.gov/28271496/","study_design":null,"title":"Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders","title_match":false,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/shared-genetic-risk-between-corticobasal-degeneration-progressive-28271184","doi":"10.1007/s00401-017-1693-y","journal":"Acta neuropathologica","n_participants":14286,"pmid":"28271184","source_url":"https://pubmed.ncbi.nlm.nih.gov/28271184/","study_design":null,"title":"Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia","title_match":true,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/multimodal-brain-imaging-reveals-structural-differences-in-alzheimer-27157680","doi":"10.1016/j.biopsych.2016.02.033","journal":"Biological psychiatry","n_participants":272,"pmid":"27157680","source_url":"https://pubmed.ncbi.nlm.nih.gov/27157680/","study_design":null,"title":"Multimodal Brain Imaging Reveals Structural Differences in Alzheimer's Disease Polygenic Risk Carriers: A Study in Healthy Young Adults","title_match":true,"year":2017},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/ethnic-and-trans-ethnic-genome-wide-association-studies-identify-new-33654092","doi":"10.1038/s41398-021-01272-3","journal":"Translational psychiatry","n_participants":null,"pmid":"33654092","source_url":"https://pubmed.ncbi.nlm.nih.gov/33654092/","study_design":"meta-analysis","title":"Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer's disease risk","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-links-between-cardiovascular-diseases-and-alzheimer-s-disease-32727331","doi":"10.2174/1570159x18666200729093724","journal":"Current neuropharmacology","n_participants":null,"pmid":"32727331","source_url":"https://pubmed.ncbi.nlm.nih.gov/32727331/","study_design":null,"title":"The Links between Cardiovascular Diseases and Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/genome-wide-association-analyses-identify-139-loci-associated-with-30535121","doi":"10.1093/hmg/ddy422","journal":"Human molecular genetics","n_participants":423,"pmid":"30535121","source_url":"https://pubmed.ncbi.nlm.nih.gov/30535121/","study_design":null,"title":"Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/genomics-implicates-adaptive-and-innate-immunity-in-alzheimer-s-and-28097204","doi":"10.1002/acn3.369","journal":"Annals of clinical and translational neurology","n_participants":null,"pmid":"28097204","source_url":"https://pubmed.ncbi.nlm.nih.gov/28097204/","study_design":null,"title":"Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases","title_match":false,"year":2016},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/measuring-heritable-contributions-to-alzheimer-s-disease-polygenic-35169705","doi":"10.1093/braincomms/fcab308","journal":"Brain communications","n_participants":1586,"pmid":"35169705","source_url":"https://pubmed.ncbi.nlm.nih.gov/35169705/","study_design":null,"title":"Measuring heritable contributions to Alzheimer's disease: polygenic risk score analysis with twins","title_match":true,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/evaluation-of-a-genetic-risk-score-to-improve-risk-prediction-for-27340842","doi":"10.3233/jad-150749","journal":"Journal of Alzheimer's disease : JAD","n_participants":19687,"pmid":"27340842","source_url":"https://pubmed.ncbi.nlm.nih.gov/27340842/","study_design":null,"title":"Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease","title_match":true,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-22-single-nucleotide-polymorphism-alzheimer-s-disease-risk-score-26086184","doi":"10.1016/j.jalz.2015.02.013","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26086184","source_url":"https://pubmed.ncbi.nlm.nih.gov/26086184/","study_design":null,"title":"A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid A\u03b242","title_match":true,"year":2015},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/cardiovascular-disease-contributes-to-alzheimer-s-disease-evidence-24231519","doi":"10.1016/j.neurobiolaging.2013.10.084","journal":"Neurobiology of aging","n_participants":14138,"pmid":"24231519","source_url":"https://pubmed.ncbi.nlm.nih.gov/24231519/","study_design":"meta-analysis","title":"Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genes-and-cognition-in-the-nondemented-general-22592056","doi":"10.1016/j.biopsych.2012.04.009","journal":"Biological psychiatry","n_participants":null,"pmid":"22592056","source_url":"https://pubmed.ncbi.nlm.nih.gov/22592056/","study_design":null,"title":"Alzheimer's disease genes and cognition in the nondemented general population","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/mild-traumatic-brain-injury-is-associated-with-reduced-cortical-28077398","doi":"10.1093/brain/aww344","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"28077398","source_url":"https://pubmed.ncbi.nlm.nih.gov/28077398/","study_design":"cross-sectional","title":"Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetics-of-parkinson-s-disease-the-yield-24262184","doi":"10.1016/s1353-8020(13)70011-7","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"24262184","source_url":"https://pubmed.ncbi.nlm.nih.gov/24262184/","study_design":null,"title":"Genetics of Parkinson's disease: the yield","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/biomarkers-in-sporadic-and-familial-alzheimer-s-disease-26401553","doi":"10.3233/jad-143006","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26401553","source_url":"https://pubmed.ncbi.nlm.nih.gov/26401553/","study_design":null,"title":"Biomarkers in Sporadic and Familial Alzheimer's Disease","title_match":true,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/step-by-step-towards-a-better-understanding-of-the-genetic-37131074","doi":"10.1038/s41380-023-02076-1","journal":"Molecular psychiatry","n_participants":null,"pmid":"37131074","source_url":"https://pubmed.ncbi.nlm.nih.gov/37131074/","study_design":null,"title":"Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-genetics-of-dementia-with-lewy-bodies-current-understanding-and-30097731","doi":"10.1007/s11910-018-0874-y","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"30097731","source_url":"https://pubmed.ncbi.nlm.nih.gov/30097731/","study_design":null,"title":"The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-s-disease-23142261","doi":"10.1016/j.arcmed.2012.10.017","journal":"Archives of medical research","n_participants":null,"pmid":"23142261","source_url":"https://pubmed.ncbi.nlm.nih.gov/23142261/","study_design":null,"title":"Genetics of Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/genome-wide-association-analysis-of-age-at-onset-in-alzheimer-s-22005931","doi":"10.1038/mp.2011.135","journal":"Molecular psychiatry","n_participants":2222,"pmid":"22005931","source_url":"https://pubmed.ncbi.nlm.nih.gov/22005931/","study_design":"meta-analysis","title":"Genome-wide association analysis of age-at-onset in Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/pooled-dna-sequencing-identifies-novel-causative-variants-in-psen1-22906081","doi":"10.1186/alzrt137","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"22906081","source_url":"https://pubmed.ncbi.nlm.nih.gov/22906081/","study_design":null,"title":"Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort","title_match":true,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/screening-of-dementia-genes-by-whole-exome-sequencing-in-early-onset-26242991","doi":"10.1038/ejhg.2015.173","journal":"European journal of human genetics : EJHG","n_participants":264,"pmid":"26242991","source_url":"https://pubmed.ncbi.nlm.nih.gov/26242991/","study_design":null,"title":"Screening of dementia genes by whole-exome sequencing in early-onset Alzheimer disease: input and lessons","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/sqstm1-splice-site-mutation-in-distal-myopathy-with-rimmed-vacuoles-26208961","doi":"10.1212/wnl.0000000000001864","journal":"Neurology","n_participants":null,"pmid":"26208961","source_url":"https://pubmed.ncbi.nlm.nih.gov/26208961/","study_design":null,"title":"SQSTM1 splice site mutation in distal myopathy with rimmed vacuoles","title_match":false,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/identification-of-genetic-risk-factors-in-the-chinese-population-29432188","doi":"10.1073/pnas.1715554115","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"29432188","source_url":"https://pubmed.ncbi.nlm.nih.gov/29432188/","study_design":null,"title":"Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis","title_match":true,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/instrumental-variable-approaches-to-identifying-the-causal-effect-of-26633592","doi":"10.1016/j.annepidem.2015.10.006","journal":"Annals of epidemiology","n_participants":7981,"pmid":"26633592","source_url":"https://pubmed.ncbi.nlm.nih.gov/26633592/","study_design":null,"title":"Instrumental variable approaches to identifying the causal effect of educational attainment on dementia risk","title_match":false,"year":2016},{"alzhub_score":86,"alzhub_url":"https://alzhub.org/study/genome-wide-significant-risk-factors-for-alzheimer-s-disease-role-in-26976043","doi":"10.1038/mp.2016.18","journal":"Molecular psychiatry","n_participants":853,"pmid":"26976043","source_url":"https://pubmed.ncbi.nlm.nih.gov/26976043/","study_design":"meta-analysis","title":"Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/pm20d1-is-a-quantitative-trait-locus-associated-with-alzheimer-s-29736028","doi":"10.1038/s41591-018-0013-y","journal":"Nature medicine","n_participants":null,"pmid":"29736028","source_url":"https://pubmed.ncbi.nlm.nih.gov/29736028/","study_design":null,"title":"PM20D1 is a\u00a0quantitative trait locus associated with Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/genetic-analysis-of-inherited-leukodystrophies-genotype-phenotype-23649896","doi":"10.1001/jamaneurol.2013.698","journal":"JAMA neurology","n_participants":114,"pmid":"23649896","source_url":"https://pubmed.ncbi.nlm.nih.gov/23649896/","study_design":null,"title":"Genetic analysis of inherited leukodystrophies: genotype-phenotype correlations in the CSF1R gene","title_match":true,"year":2013},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/gba-and-apoe-4-associate-with-sporadic-dementia-with-lewy-bodies-in-31065058","doi":"10.1038/s41598-019-43458-2","journal":"Scientific reports","n_participants":19,"pmid":"31065058","source_url":"https://pubmed.ncbi.nlm.nih.gov/31065058/","study_design":null,"title":"GBA and APOE \u03b54 associate with sporadic dementia with Lewy bodies in European genome wide association study","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/lt-i-gt-complement-c7-lt-i-gt-is-a-novel-risk-gene-for-alzheimer-s-31032141","doi":"10.1093/nsr/nwy127","journal":"National science review","n_participants":null,"pmid":"31032141","source_url":"https://pubmed.ncbi.nlm.nih.gov/31032141/","study_design":null,"title":"Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/exome-sequencing-reveals-an-unexpected-genetic-cause-of-disease-22153900","doi":"10.1016/j.neurobiolaging.2011.10.009","journal":"Neurobiology of aging","n_participants":null,"pmid":"22153900","source_url":"https://pubmed.ncbi.nlm.nih.gov/22153900/","study_design":null,"title":"Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/genome-wide-association-reveals-genetic-effects-on-human-a42-and-20932310","doi":"10.1186/1471-2377-10-90","journal":"BMC neurology","n_participants":410,"pmid":"20932310","source_url":"https://pubmed.ncbi.nlm.nih.gov/20932310/","study_design":null,"title":"Genome-wide association reveals genetic effects on human A\u03b242 and \u03c4 protein levels in cerebrospinal fluids: a case control study","title_match":false,"year":2010},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/bin1-is-decreased-in-sporadic-but-not-familial-alzheimer-s-disease-or-24205320","doi":"10.1371/journal.pone.0078806","journal":"PloS one","n_participants":null,"pmid":"24205320","source_url":"https://pubmed.ncbi.nlm.nih.gov/24205320/","study_design":null,"title":"BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging","title_match":true,"year":2013},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/genetic-risk-for-schizophrenia-and-psychosis-in-alzheimer-disease-28461698","doi":"10.1038/mp.2017.81","journal":"Molecular psychiatry","n_participants":1761,"pmid":"28461698","source_url":"https://pubmed.ncbi.nlm.nih.gov/28461698/","study_design":null,"title":"Genetic risk for schizophrenia and psychosis in Alzheimer disease","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genomics-and-functional-genomics-of-alzheimer-s-disease-34935119","doi":"10.1007/s13311-021-01152-0","journal":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","n_participants":null,"pmid":"34935119","source_url":"https://pubmed.ncbi.nlm.nih.gov/34935119/","study_design":null,"title":"Genomics and Functional Genomics of Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/calmodulin-binding-proteins-and-alzheimer-s-disease-25812852","doi":"10.3233/jad-142772","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25812852","source_url":"https://pubmed.ncbi.nlm.nih.gov/25812852/","study_design":null,"title":"Calmodulin Binding Proteins and Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/herpesvirus-infections-and-alzheimer-s-disease-a-mendelian-34560893","doi":"10.1186/s13195-021-00905-5","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"34560893","source_url":"https://pubmed.ncbi.nlm.nih.gov/34560893/","study_design":null,"title":"Herpesvirus infections and Alzheimer's disease: a Mendelian randomization study","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/intracellular-clusterin-interacts-with-brain-isoforms-of-the-bridging-25051234","doi":"10.1371/journal.pone.0103187","journal":"PloS one","n_participants":null,"pmid":"25051234","source_url":"https://pubmed.ncbi.nlm.nih.gov/25051234/","study_design":null,"title":"Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-disease-in-the-pre-and-post-gwas-era-20236449","doi":"10.1186/alzrt26","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"20236449","source_url":"https://pubmed.ncbi.nlm.nih.gov/20236449/","study_design":null,"title":"Genetics of Alzheimer disease in the pre- and post-GWAS era","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/molecular-genetics-of-addiction-and-related-heritable-phenotypes-18991966","doi":"10.1196/annals.1441.018","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"18991966","source_url":"https://pubmed.ncbi.nlm.nih.gov/18991966/","study_design":null,"title":"Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify \"connectivity constellation\" and drug target genes with pleiotropic effects","title_match":true,"year":2008},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-risk-gene-lt-i-gt-bin1-lt-i-gt-induces-tau-32657270","doi":"10.7554/elife.57354","journal":"eLife","n_participants":null,"pmid":"32657270","source_url":"https://pubmed.ncbi.nlm.nih.gov/32657270/","study_design":null,"title":"Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-synuclein-seeding-activity-and-contributes-to-35471463","doi":"10.1007/s00401-022-02421-8","journal":"Acta neuropathologica","n_participants":469,"pmid":"35471463","source_url":"https://pubmed.ncbi.nlm.nih.gov/35471463/","study_design":null,"title":"APOE4 exacerbates \u03b1-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/y-chromosome-mosaicism-is-associated-with-age-related-macular-30158665","doi":"10.1038/s41431-018-0238-8","journal":"European journal of human genetics : EJHG","n_participants":null,"pmid":"30158665","source_url":"https://pubmed.ncbi.nlm.nih.gov/30158665/","study_design":null,"title":"Y chromosome mosaicism is associated with age-related macular degeneration","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-for-alzheimer-s-disease-implications-for-memory-29495896","doi":"10.1176/appi.ajp.2017.17050529","journal":"The American journal of psychiatry","n_participants":364,"pmid":"29495896","source_url":"https://pubmed.ncbi.nlm.nih.gov/29495896/","study_design":null,"title":"Polygenic Risk Score for Alzheimer's Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life","title_match":true,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/deleterious-abca7-mutations-and-transcript-rescue-mechanisms-in-early-28447221","doi":"10.1007/s00401-017-1714-x","journal":"Acta neuropathologica","n_participants":null,"pmid":"28447221","source_url":"https://pubmed.ncbi.nlm.nih.gov/28447221/","study_design":null,"title":"Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/polygenic-analysis-of-late-onset-alzheimer-s-disease-from-mainland-26680604","doi":"10.1371/journal.pone.0144898","journal":"PloS one","n_participants":null,"pmid":"26680604","source_url":"https://pubmed.ncbi.nlm.nih.gov/26680604/","study_design":null,"title":"Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China","title_match":true,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/link-between-the-snca-gene-and-parkinsonism-25554495","doi":"10.1016/j.neurobiolaging.2014.10.042","journal":"Neurobiology of aging","n_participants":null,"pmid":"25554495","source_url":"https://pubmed.ncbi.nlm.nih.gov/25554495/","study_design":null,"title":"Link between the SNCA gene and parkinsonism","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genetics-current-knowledge-and-future-challenges-20957767","doi":"10.1002/gps.2628","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"20957767","source_url":"https://pubmed.ncbi.nlm.nih.gov/20957767/","study_design":null,"title":"Alzheimer's disease genetics: current knowledge and future challenges","title_match":false,"year":2011},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/recent-updates-on-the-genetics-of-amyotrophic-lateral-sclerosis-and-35768750","doi":"10.1007/s12035-022-02934-z","journal":"Molecular neurobiology","n_participants":null,"pmid":"35768750","source_url":"https://pubmed.ncbi.nlm.nih.gov/35768750/","study_design":null,"title":"Recent Updates on the Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia","title_match":false,"year":2022},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/immune-response-and-endocytosis-pathways-are-associated-with-the-32994401","doi":"10.1038/s41398-020-01018-7","journal":"Translational psychiatry","n_participants":1895,"pmid":"32994401","source_url":"https://pubmed.ncbi.nlm.nih.gov/32994401/","study_design":"longitudinal study","title":"Immune response and endocytosis pathways are associated with the resilience against Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/sex-dependent-autosomal-effects-on-clinical-progression-of-alzheimer-32591829","doi":"10.1093/brain/awaa164","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"32591829","source_url":"https://pubmed.ncbi.nlm.nih.gov/32591829/","study_design":null,"title":"Sex-dependent autosomal effects on clinical progression of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/using-an-alzheimer-disease-polygenic-risk-score-to-predict-memory-26756387","doi":"10.1097/wad.0000000000000137","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"26756387","source_url":"https://pubmed.ncbi.nlm.nih.gov/26756387/","study_design":null,"title":"Using an Alzheimer Disease Polygenic Risk Score to Predict Memory Decline in Black and White Americans Over 14 Years of Follow-up","title_match":true,"year":2016},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/a-comprehensive-analysis-of-methods-for-assessing-polygenic-burden-on-32226939","doi":"10.1093/braincomms/fcz047","journal":"Brain communications","n_participants":null,"pmid":"32226939","source_url":"https://pubmed.ncbi.nlm.nih.gov/32226939/","study_design":"cross-sectional","title":"A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond APOE","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genome-wide-high-content-sirna-screening-identifies-the-alzheimer-s-27933404","doi":"10.1007/s00401-016-1652-z","journal":"Acta neuropathologica","n_participants":null,"pmid":"27933404","source_url":"https://pubmed.ncbi.nlm.nih.gov/27933404/","study_design":null,"title":"Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism","title_match":true,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/increased-expression-of-the-frontotemporal-dementia-risk-factor-27126638","doi":"10.1093/hmg/ddw127","journal":"Human molecular genetics","n_participants":null,"pmid":"27126638","source_url":"https://pubmed.ncbi.nlm.nih.gov/27126638/","study_design":null,"title":"Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/shared-genetic-etiology-underlying-alzheimer-s-disease-and-major-32152295","doi":"10.1038/s41398-020-0769-y","journal":"Translational psychiatry","n_participants":null,"pmid":"32152295","source_url":"https://pubmed.ncbi.nlm.nih.gov/32152295/","study_design":null,"title":"Shared genetic etiology underlying Alzheimer's disease and major depressive disorder","title_match":false,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/polygenic-risk-scores-in-familial-alzheimer-disease-28213371","doi":"10.1212/wnl.0000000000003734","journal":"Neurology","n_participants":null,"pmid":"28213371","source_url":"https://pubmed.ncbi.nlm.nih.gov/28213371/","study_design":null,"title":"Polygenic risk scores in familial Alzheimer disease","title_match":true,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-multi-faceted-role-of-mitochondria-in-the-pathology-of-parkinson-33616931","doi":"10.1111/jnc.15154","journal":"Journal of neurochemistry","n_participants":null,"pmid":"33616931","source_url":"https://pubmed.ncbi.nlm.nih.gov/33616931/","study_design":null,"title":"The multi-faceted role of mitochondria in the pathology of Parkinson's disease","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-scientific-breakthroughs-and-translational-28578785","doi":"10.1016/j.mayocp.2017.02.011","journal":"Mayo Clinic proceedings","n_participants":null,"pmid":"28578785","source_url":"https://pubmed.ncbi.nlm.nih.gov/28578785/","study_design":null,"title":"Alzheimer Disease: Scientific Breakthroughs and Translational Challenges","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-contribution-of-genetic-factors-to-cognitive-impairment-and-30866553","doi":"10.3390/ijms20051177","journal":"International journal of molecular sciences","n_participants":null,"pmid":"30866553","source_url":"https://pubmed.ncbi.nlm.nih.gov/30866553/","study_design":null,"title":"The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk","title_match":true,"year":2019},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/whole-genome-sequencing-suggests-a-chemokine-gene-cluster-that-26324103","doi":"10.1038/mp.2015.131","journal":"Molecular psychiatry","n_participants":72,"pmid":"26324103","source_url":"https://pubmed.ncbi.nlm.nih.gov/26324103/","study_design":null,"title":"Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease","title_match":true,"year":2015},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/genome-wide-association-identifies-the-first-risk-loci-for-psychosis-34112972","doi":"10.1038/s41380-021-01152-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"34112972","source_url":"https://pubmed.ncbi.nlm.nih.gov/34112972/","study_design":"meta-analysis","title":"Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/tnf-mediated-reduction-in-inhibitory-neurotransmission-precedes-33434745","doi":"10.1074/jbc.ra120.016395","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"33434745","source_url":"https://pubmed.ncbi.nlm.nih.gov/33434745/","study_design":null,"title":"TNF-\u03b1-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2R47H rats","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/genetic-screen-in-a-large-series-of-patients-with-primary-progressive-30599136","doi":"10.1016/j.jalz.2018.10.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"30599136","source_url":"https://pubmed.ncbi.nlm.nih.gov/30599136/","study_design":null,"title":"Genetic screen in a large series of patients with primary progressive aphasia","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/effect-of-i-apoe-i-alleles-on-the-glial-transcriptome-in-normal-aging-36199750","doi":"10.1038/s43587-021-00123-6","journal":"Nature aging","n_participants":null,"pmid":"36199750","source_url":"https://pubmed.ncbi.nlm.nih.gov/36199750/","study_design":null,"title":"Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-apoe-4-exerts-differential-effects-on-familial-and-other-subtypes-32881347","doi":"10.1002/alz.12153","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":119,"pmid":"32881347","source_url":"https://pubmed.ncbi.nlm.nih.gov/32881347/","study_design":null,"title":"The APOE \u03b54 exerts differential effects on familial and other subtypes of Alzheimer's disease","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/from-common-to-rare-variants-the-genetic-component-of-alzheimer-28002825","doi":"10.1159/000452256","journal":"Human heredity","n_participants":null,"pmid":"28002825","source_url":"https://pubmed.ncbi.nlm.nih.gov/28002825/","study_design":null,"title":"From Common to Rare Variants: The Genetic Component of Alzheimer Disease","title_match":false,"year":2016},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/a-neurodegenerative-disease-landscape-of-rare-mutations-in-colombia-35260199","doi":"10.1186/s13073-022-01035-9","journal":"Genome medicine","n_participants":376,"pmid":"35260199","source_url":"https://pubmed.ncbi.nlm.nih.gov/35260199/","study_design":null,"title":"A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/cannabidiol-ameliorates-cognitive-function-via-regulation-of-il-33-33612548","doi":"10.3233/jad-210026","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"33612548","source_url":"https://pubmed.ncbi.nlm.nih.gov/33612548/","study_design":null,"title":"Cannabidiol Ameliorates Cognitive Function via Regulation of IL-33 and TREM2 Upregulation in a Murine Model of Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/characterizing-molecular-and-synaptic-signatures-in-mouse-models-of-38735056","doi":"10.1002/alz.13828","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38735056","source_url":"https://pubmed.ncbi.nlm.nih.gov/38735056/","study_design":null,"title":"Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genetic-phenotypes-of-alzheimer-s-disease-mechanisms-and-potential-37589021","doi":"10.1007/s43657-023-00098-x","journal":"Phenomics (Cham, Switzerland)","n_participants":null,"pmid":"37589021","source_url":"https://pubmed.ncbi.nlm.nih.gov/37589021/","study_design":null,"title":"Genetic Phenotypes of Alzheimer's Disease: Mechanisms and Potential Therapy","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-s-disease-30906402","doi":"10.12779/dnd.2018.17.4.131","journal":"Dementia and neurocognitive disorders","n_participants":null,"pmid":"30906402","source_url":"https://pubmed.ncbi.nlm.nih.gov/30906402/","study_design":null,"title":"Genetics of Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/bilberry-anthocyanins-improve-neuroinflammation-and-cognitive-32003387","doi":"10.1039/c9fo02103e","journal":"Food & function","n_participants":null,"pmid":"32003387","source_url":"https://pubmed.ncbi.nlm.nih.gov/32003387/","study_design":null,"title":"Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-impact-of-rare-genetic-variants-on-alzheimer-disease-39905212","doi":"10.1038/s41582-025-01062-1","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"39905212","source_url":"https://pubmed.ncbi.nlm.nih.gov/39905212/","study_design":null,"title":"The impact of rare genetic variants on Alzheimer disease","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/trem2-analysis-and-increased-risk-of-alzheimer-s-disease-25260849","doi":"10.1016/j.neurobiolaging.2014.08.001","journal":"Neurobiology of aging","n_participants":null,"pmid":"25260849","source_url":"https://pubmed.ncbi.nlm.nih.gov/25260849/","study_design":null,"title":"TREM2 analysis and increased risk of Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-human-specific-casp4-gene-product-contributes-to-alzheimer-27516385","doi":"10.1093/hmg/ddw265","journal":"Human molecular genetics","n_participants":null,"pmid":"27516385","source_url":"https://pubmed.ncbi.nlm.nih.gov/27516385/","study_design":null,"title":"The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits","title_match":false,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/microglial-phagocytosis-in-alzheimer-disease-41315858","doi":"10.1038/s41582-025-01162-y","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"41315858","source_url":"https://pubmed.ncbi.nlm.nih.gov/41315858/","study_design":null,"title":"Microglial phagocytosis in Alzheimer disease","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/genome-sequencing-for-early-onset-or-atypical-dementia-high-31836585","doi":"10.1101/mcs.a003491","journal":"Cold Spring Harbor molecular case studies","n_participants":32,"pmid":"31836585","source_url":"https://pubmed.ncbi.nlm.nih.gov/31836585/","study_design":null,"title":"Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/misframed-ubiquitin-and-impaired-protein-quality-control-an-early-26388726","doi":"10.3389/fnmol.2015.00047","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"26388726","source_url":"https://pubmed.ncbi.nlm.nih.gov/26388726/","study_design":null,"title":"Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/variable-expression-of-microglial-dap12-and-trem2-genes-in-nasu-26001891","doi":"10.1007/s10048-015-0451-3","journal":"Neurogenetics","n_participants":null,"pmid":"26001891","source_url":"https://pubmed.ncbi.nlm.nih.gov/26001891/","study_design":null,"title":"Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuropsychological-tests-and-functional-nuclear-neuroimaging-provide-15966270","doi":null,"journal":"Functional neurology","n_participants":null,"pmid":"15966270","source_url":"https://pubmed.ncbi.nlm.nih.gov/15966270/","study_design":null,"title":"Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes","title_match":false,"year":2005},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/microglia-gravitate-toward-amyloid-plaques-surrounded-by-externalized-38981007","doi":"10.1002/advs.202400064","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","n_participants":null,"pmid":"38981007","source_url":"https://pubmed.ncbi.nlm.nih.gov/38981007/","study_design":null,"title":"Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/weighted-burden-analysis-of-exome-sequenced-late-onset-alzheimer-s-32020597","doi":"10.1111/ahg.12375","journal":"Annals of human genetics","n_participants":null,"pmid":"32020597","source_url":"https://pubmed.ncbi.nlm.nih.gov/32020597/","study_design":null,"title":"Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3\u03b2 and WNT signalling pathways","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/homozygous-carriers-of-app-a713t-mutation-in-an-autosomal-dominant-25948718","doi":"10.1212/wnl.0000000000001648","journal":"Neurology","n_participants":null,"pmid":"25948718","source_url":"https://pubmed.ncbi.nlm.nih.gov/25948718/","study_design":null,"title":"Homozygous carriers of APP A713T mutation in an autosomal dominant Alzheimer disease family","title_match":true,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/chronic-ethanol-causes-persistent-increases-in-alzheimer-s-tau-35645744","doi":"10.3389/fnbeh.2022.886634","journal":"Frontiers in behavioral neuroscience","n_participants":null,"pmid":"35645744","source_url":"https://pubmed.ncbi.nlm.nih.gov/35645744/","study_design":null,"title":"Chronic Ethanol Causes Persistent Increases in Alzheimer's Tau Pathology in Female 3xTg-AD Mice: A Potential Role for Lysosomal Impairment","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/three-dimensions-of-the-amyloid-hypothesis-time-space-and-wingmen-26007213","doi":"10.1038/nn.4018","journal":"Nature neuroscience","n_participants":null,"pmid":"26007213","source_url":"https://pubmed.ncbi.nlm.nih.gov/26007213/","study_design":null,"title":"Three dimensions of the amyloid hypothesis: time, space and 'wingmen'","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/autophagy-failure-in-alzheimer-s-disease-locating-the-primary-defect-21296668","doi":"10.1016/j.nbd.2011.01.021","journal":"Neurobiology of disease","n_participants":null,"pmid":"21296668","source_url":"https://pubmed.ncbi.nlm.nih.gov/21296668/","study_design":null,"title":"Autophagy failure in Alzheimer's disease--locating the primary defect","title_match":false,"year":2011},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/mapping-of-a-gene-for-parkinson-s-disease-to-chromosome-4q21-q23-8895469","doi":"10.1126/science.274.5290.1197","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"8895469","source_url":"https://pubmed.ncbi.nlm.nih.gov/8895469/","study_design":null,"title":"Mapping of a gene for Parkinson's disease to chromosome 4q21-q23","title_match":false,"year":1996},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/notch-and-presenilin-regulated-intramembrane-proteolysis-links-12730322","doi":"10.1146/annurev.neuro.26.041002.131334","journal":"Annual review of neuroscience","n_participants":null,"pmid":"12730322","source_url":"https://pubmed.ncbi.nlm.nih.gov/12730322/","study_design":null,"title":"Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration","title_match":true,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/maturation-of-autophagic-vacuoles-in-mammalian-cells-16874026","doi":"10.4161/auto.1.1.1270","journal":"Autophagy","n_participants":null,"pmid":"16874026","source_url":"https://pubmed.ncbi.nlm.nih.gov/16874026/","study_design":null,"title":"Maturation of autophagic vacuoles in Mammalian cells","title_match":false,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/impaired-mitochondrial-biogenesis-contributes-to-mitochondrial-22077634","doi":"10.1111/j.1471-4159.2011.07581.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"22077634","source_url":"https://pubmed.ncbi.nlm.nih.gov/22077634/","study_design":null,"title":"Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-alzheimer-s-disease-a-review-and-proposal-for-the-21211070","doi":"10.1186/alzrt59","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"21211070","source_url":"https://pubmed.ncbi.nlm.nih.gov/21211070/","study_design":null,"title":"Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/an-atomic-structure-of-human-secretase-26280335","doi":"10.1038/nature14892","journal":"Nature","n_participants":null,"pmid":"26280335","source_url":"https://pubmed.ncbi.nlm.nih.gov/26280335/","study_design":null,"title":"An atomic structure of human \u03b3-secretase","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/increased-app-expression-in-a-mouse-model-of-down-s-syndrome-disrupts-16815330","doi":"10.1016/j.neuron.2006.05.022","journal":"Neuron","n_participants":null,"pmid":"16815330","source_url":"https://pubmed.ncbi.nlm.nih.gov/16815330/","study_design":null,"title":"Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration","title_match":false,"year":2006},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/kinesin-mediated-axonal-transport-of-a-membrane-compartment-11740561","doi":"10.1038/414643a","journal":"Nature","n_participants":null,"pmid":"11740561","source_url":"https://pubmed.ncbi.nlm.nih.gov/11740561/","study_design":null,"title":"Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP","title_match":true,"year":2001},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/a-gamma-secretase-inhibitor-blocks-notch-signaling-in-vivo-and-causes-12101103","doi":"10.1093/embo-reports/kvf124","journal":"EMBO reports","n_participants":null,"pmid":"12101103","source_url":"https://pubmed.ncbi.nlm.nih.gov/12101103/","study_design":null,"title":"A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish","title_match":false,"year":2002},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/destabilization-of-beta-catenin-by-mutations-in-presenilin-1-9790190","doi":"10.1038/27208","journal":"Nature","n_participants":null,"pmid":"9790190","source_url":"https://pubmed.ncbi.nlm.nih.gov/9790190/","study_design":null,"title":"Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis","title_match":true,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/modulation-of-the-endoplasmic-reticulum-mitochondria-interface-in-23620518","doi":"10.1073/pnas.1300677110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"23620518","source_url":"https://pubmed.ncbi.nlm.nih.gov/23620518/","study_design":null,"title":"Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/presenilin-1-mutations-downregulate-the-signalling-pathway-of-the-10587643","doi":"10.1038/70265","journal":"Nature cell biology","n_participants":null,"pmid":"10587643","source_url":"https://pubmed.ncbi.nlm.nih.gov/10587643/","study_design":null,"title":"Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response","title_match":true,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/presenilin-2-deficiency-causes-a-mild-pulmonary-phenotype-and-no-10518543","doi":"10.1073/pnas.96.21.11872","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10518543","source_url":"https://pubmed.ncbi.nlm.nih.gov/10518543/","study_design":null,"title":"Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency","title_match":true,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/transition-state-analogue-inhibitors-of-gamma-secretase-bind-directly-10878808","doi":"10.1038/35017062","journal":"Nature cell biology","n_participants":null,"pmid":"10878808","source_url":"https://pubmed.ncbi.nlm.nih.gov/10878808/","study_design":null,"title":"Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1","title_match":true,"year":2000},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alzheimer-associated-presenilins-1-and-2-neuronal-expression-in-brain-8574969","doi":"10.1038/nm0296-224","journal":"Nature medicine","n_participants":null,"pmid":"8574969","source_url":"https://pubmed.ncbi.nlm.nih.gov/8574969/","study_design":null,"title":"Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells","title_match":false,"year":1996},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/estrogen-reduces-neuronal-generation-of-alzheimer-beta-amyloid-9546791","doi":"10.1038/nm0498-447","journal":"Nature medicine","n_participants":null,"pmid":"9546791","source_url":"https://pubmed.ncbi.nlm.nih.gov/9546791/","study_design":null,"title":"Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides","title_match":false,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-many-substrates-of-presenilin-secretase-21335653","doi":"10.3233/jad-2011-101065","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21335653","source_url":"https://pubmed.ncbi.nlm.nih.gov/21335653/","study_design":null,"title":"The many substrates of presenilin/\u03b3-secretase","title_match":true,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/oxidative-damage-of-dj-1-is-linked-to-sporadic-parkinson-and-16517609","doi":"10.1074/jbc.m509079200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16517609","source_url":"https://pubmed.ncbi.nlm.nih.gov/16517609/","study_design":null,"title":"Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases","title_match":false,"year":2006},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/natural-dietary-supplementation-of-anthocyanins-via-pi3k-akt-nrf2-ho-29170981","doi":"10.1007/s12035-017-0798-6","journal":"Molecular neurobiology","n_participants":null,"pmid":"29170981","source_url":"https://pubmed.ncbi.nlm.nih.gov/29170981/","study_design":null,"title":"Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurogenic-phenotypes-and-altered-notch-processing-in-drosophila-10206647","doi":"10.1038/19096","journal":"Nature","n_participants":null,"pmid":"10206647","source_url":"https://pubmed.ncbi.nlm.nih.gov/10206647/","study_design":null,"title":"Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants","title_match":true,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/divergence-of-human-and-mouse-brain-transcriptome-highlights-20616000","doi":"10.1073/pnas.0914257107","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"20616000","source_url":"https://pubmed.ncbi.nlm.nih.gov/20616000/","study_design":null,"title":"Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mechanism-of-ca2-disruption-in-alzheimer-s-disease-by-presenilin-18579078","doi":"10.1016/j.neuron.2008.04.015","journal":"Neuron","n_participants":null,"pmid":"18579078","source_url":"https://pubmed.ncbi.nlm.nih.gov/18579078/","study_design":null,"title":"Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating","title_match":true,"year":2008},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/increased-vulnerability-of-hippocampal-neurons-to-excitotoxic-9883847","doi":"10.1038/4789","journal":"Nature medicine","n_participants":null,"pmid":"9883847","source_url":"https://pubmed.ncbi.nlm.nih.gov/9883847/","study_design":null,"title":"Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice","title_match":true,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/antiamyloidogenic-and-neuroprotective-functions-of-cathepsin-b-16982417","doi":"10.1016/j.neuron.2006.07.027","journal":"Neuron","n_participants":null,"pmid":"16982417","source_url":"https://pubmed.ncbi.nlm.nih.gov/16982417/","study_design":null,"title":"Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/chip-hsc70-complex-ubiquitinates-phosphorylated-tau-and-enhances-cell-14612456","doi":"10.1074/jbc.m305838200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"14612456","source_url":"https://pubmed.ncbi.nlm.nih.gov/14612456/","study_design":null,"title":"CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival","title_match":false,"year":2004},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/mice-lacking-both-presenilin-genes-exhibit-early-embryonic-patterning-10557208","doi":"10.1101/gad.13.21.2801","journal":"Genes & development","n_participants":null,"pmid":"10557208","source_url":"https://pubmed.ncbi.nlm.nih.gov/10557208/","study_design":null,"title":"Mice lacking both presenilin genes exhibit early embryonic patterning defects","title_match":true,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/regulation-of-cholesterol-and-sphingomyelin-metabolism-by-amyloid-16227967","doi":"10.1038/ncb1313","journal":"Nature cell biology","n_participants":null,"pmid":"16227967","source_url":"https://pubmed.ncbi.nlm.nih.gov/16227967/","study_design":null,"title":"Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin","title_match":true,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/synapses-and-alzheimer-s-disease-22491782","doi":"10.1101/cshperspect.a005777","journal":"Cold Spring Harbor perspectives in biology","n_participants":null,"pmid":"22491782","source_url":"https://pubmed.ncbi.nlm.nih.gov/22491782/","study_design":null,"title":"Synapses and Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-presenilin-mutation-sensitizes-neural-cells-to-apoptosis-9151738","doi":"10.1523/jneurosci.17-11-04212.1997","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"9151738","source_url":"https://pubmed.ncbi.nlm.nih.gov/9151738/","study_design":null,"title":"Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals","title_match":true,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/disruption-of-neurogenesis-by-amyloid-beta-peptide-and-perturbed-12472904","doi":"10.1046/j.1471-4159.2002.01267.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"12472904","source_url":"https://pubmed.ncbi.nlm.nih.gov/12472904/","study_design":null,"title":"Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease","title_match":false,"year":2002},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/gamma-secretase-gene-mutations-in-familial-acne-inversa-20929727","doi":"10.1126/science.1196284","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"20929727","source_url":"https://pubmed.ncbi.nlm.nih.gov/20929727/","study_design":null,"title":"Gamma-secretase gene mutations in familial acne inversa","title_match":true,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/microrna-regulation-of-alzheimer-s-amyloid-precursor-protein-19110058","doi":"10.1016/j.nbd.2008.11.009","journal":"Neurobiology of disease","n_participants":null,"pmid":"19110058","source_url":"https://pubmed.ncbi.nlm.nih.gov/19110058/","study_design":null,"title":"MicroRNA regulation of Alzheimer's Amyloid precursor protein expression","title_match":false,"year":2009},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/ripk1-mediates-a-disease-associated-microglial-response-in-alzheimer-28904096","doi":"10.1073/pnas.1714175114","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"28904096","source_url":"https://pubmed.ncbi.nlm.nih.gov/28904096/","study_design":null,"title":"RIPK1 mediates a disease-associated microglial response in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/association-of-gamma-secretase-with-lipid-rafts-in-post-golgi-and-15322084","doi":"10.1074/jbc.m407986200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"15322084","source_url":"https://pubmed.ncbi.nlm.nih.gov/15322084/","study_design":null,"title":"Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes","title_match":false,"year":2004},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/role-of-the-prolyl-isomerase-pin1-in-protecting-against-age-dependent-12891359","doi":"10.1038/nature01832","journal":"Nature","n_participants":null,"pmid":"12891359","source_url":"https://pubmed.ncbi.nlm.nih.gov/12891359/","study_design":null,"title":"Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration","title_match":false,"year":2003}]}
